Aging genes 5-9

ARNT

Loss of ARNT in skeletal muscle limits muscle regeneration in aging. / 12.2020 / PubMed / Full text
[Arylhydrocarbon receptor nuclear translocator (ARNT) in human skin during aging.] / 2020 / PubMed
The E3 ubiquitin ligase STUB1 attenuates cell senescence by promoting the ubiquitination and degradation of the core circadian regulator BMAL1. / 03.04.2020 / PubMed / Full text
Deficiency of Bmal1 disrupts the diurnal rhythm of haemostasis. / 04.2019 / PubMed / Full text
Insulin-like growth factor-1 acts as a zeitgeber on hypothalamic circadian clock gene expression via glycogen synthase kinase-3β signaling. / 02.11.2018 / PubMed / Full text
Aging and chromatoid body assembly: Are these two physiological events linked? / 07.2018 / PubMed / Full text
Deficiency of circadian clock protein BMAL1 in mice results in a low bone mass phenotype. / 03.2016 / PubMed / Full text
Circadian clocks govern calorie restriction-mediated life span extension through BMAL1- and IGF-1-dependent mechanisms. / 04.2016 / PubMed / Full text
Whole blood thrombin generation in Bmal1-deficient mice. / 08.2014 / PubMed / Full text

BMP2

GREM1 inhibits osteogenic differentiation, senescence and BMP transcription of adipose-derived stem cells. / 09.03.2020 / PubMed / Full text
Interleukin-1β-Induced Senescence Promotes Osteoblastic Transition of Vascular Smooth Muscle Cells. / 2020 / PubMed / Full text
Long noncoding RNA Bmncr regulates mesenchymal stem cell fate during skeletal aging. / 03.12.2018 / PubMed / Full text
Synthesis of Extracellular Pyrophosphate Increases in Vascular Smooth Muscle Cells During Phosphate-Induced Calcification. / 09.2018 / PubMed / Full text
Age-Related Insulin-Like Growth Factor Binding Protein-4 Overexpression Inhibits Osteogenic Differentiation of Rat Mesenchymal Stem Cells. / 2017 / PubMed / Full text
p38α MAPK regulates proliferation and differentiation of osteoclast progenitors and bone remodeling in an aging-dependent manner. / 06.04.2017 / PubMed / Full text
Vaccination with DKK1-derived peptides promotes bone formation and bone mass in an aged mouse osteoporosis model. / 08.2014 / PubMed / Full text
Enhanced tissue regeneration potential of juvenile articular cartilage. / 11.2013 / PubMed / Full text
Age-related CXC chemokine receptor-4-deficiency impairs osteogenic differentiation potency of mouse bone marrow mesenchymal stromal stem cells. / 08.2013 / PubMed / Full text

BNIP3

Late life maintenance and enhancement of functional exercise capacity in low and high responding rats after low intensity treadmill training. / 01.10.2019 / PubMed / Full text
Regulation of apoptosis and autophagy in mouse and human skeletal muscle with aging and lifelong exercise training. / 01.10.2018 / PubMed / Full text
Effects of β-hydroxy-β-methylbutyrate on skeletal muscle mitochondrial content and dynamics, and lipids after 10 days of bed rest in older adults. / 01.11.2017 / PubMed / Full text
Akt2 ablation prolongs life span and improves myocardial contractile function with adaptive cardiac remodeling: role of Sirt1-mediated autophagy regulation. / 10.2017 / PubMed / Full text
In Brief: Mitophagy: mechanisms and role in human disease. / 11.2016 / PubMed / Full text
Mfn2 deficiency links age-related sarcopenia and impaired autophagy to activation of an adaptive mitophagy pathway. / 01.08.2016 / PubMed / Full text
Interfacing mitochondrial biogenesis and elimination to enhance host pathogen defense and longevity. / 07-09.2015 / PubMed / Full text
Coupling mitogenesis and mitophagy for longevity. / 2015 / PubMed / Full text
Dying myofibers in elderly mouse skeletal muscles are characterized by the appearance of dystrophin-encircled vacuoles. / 08.2015 / PubMed / Full text

BPIFB4

New Insights for BPIFB4 in Cardiovascular Therapy. / 28.09.2020 / PubMed / Full text
High TARC plasma levels confer protection to long living individuals by inducing M2 profile. / 01.2021 / PubMed / Full text
Circulating BPIFB4 Levels Associate With and Influence the Abundance of Reparative Monocytes and Macrophages in Long Living Individuals. / 2020 / PubMed / Full text
Transfer of a human gene variant associated with exceptional longevity improves cardiac function in obese type 2 diabetic mice through induction of the SDF-1/CXCR4 signalling pathway. / 09.2020 / PubMed / Full text
LAV-BPIFB4 associates with reduced frailty in humans and its transfer prevents frailty progression in old mice. / 28.08.2019 / PubMed / Full text
Longevity-Associated Variant of BPIFB4 Mitigates Monocyte-Mediated Acquired Immune Response. / 13.11.2019 / PubMed / Full text
A Model of Evolutionary Selection: The Cardiovascular Protective Function of the Longevity Associated Variant of BPIFB4. / 19.10.2018 / PubMed / Full text
The expression of the BPIFB4 and CXCR4 associates with sustained health in long-living individuals from Cilento-Italy. / 22.01.2017 / PubMed / Full text
Genetic Analysis Reveals a Longevity-Associated Protein Modulating Endothelial Function and Angiogenesis. / 31.07.2015 / PubMed / Full text

CCN1

Sodium tanshinone IIA sulfonate restrains fibrogenesis through induction of senescence in mice with induced deep endometriosis. / 09.2020 / PubMed / Full text
Inhibition of cellular communication network factor 1 (CCN1)-driven senescence slows down cartilage inflammaging and osteoarthritis. / 10.2020 / PubMed / Full text
[Aging of skin fibroblasts: genetic and epigenetic factors.] / 2019 / PubMed
The senescence-associated matricellular protein CCN1 in plasma of human subjects with idiopathic pulmonary fibrosis. / 01.2020 / PubMed / Full text
CCN1 (CYR61) and CCN3 (NOV) signaling drives human trophoblast cells into senescence and stimulates migration properties. / 03.03.2016 / PubMed / Full text
Aging increases CCN1 expression leading to muscle senescence. / 01.01.2014 / PubMed / Full text
Impaired intervertebral disc development and premature disc degeneration in mice with notochord-specific deletion of CCN2. / 10.2013 / PubMed / Full text
The matricellular protein CCN1 suppresses lung cancer cell growth by inducing senescence via the p53/p21 pathway. / 09.2013 / PubMed / Full text
Cysteine-rich protein 61 (CCN1) domain-specific stimulation of matrix metalloproteinase-1 expression through αVβ3 integrin in human skin fibroblasts. / 26.04.2013 / PubMed / Full text

CCR5

The Puzzling Role of Neuron-Specific PMCA Isoforms in the Aging Process. / 16.12.2019 / PubMed / Full text
[Enhancement can do harm]. / 08-09.2019 / PubMed / Full text
CCR5-∆32 is deleterious in the homozygous state in humans. / 06.2019 / PubMed / Full text
CCR5 chemokine receptor gene polymorphisms in ocular toxoplasmosis. / 02.2018 / PubMed / Full text
Peripheral loss of CD8( ) CD161( ) TCRVα7·2( ) mucosal-associated invariant T cells in chronic hepatitis C virus-infected patients. / 02.2016 / PubMed / Full text
Increased susceptibility of CD4 T cells from elderly individuals to HIV-1 infection and apoptosis is associated with reduced CD4 and enhanced CXCR4 and FAS surface expression levels. / 09.10.2015 / PubMed / Full text
Aging-associated subpopulations of human CD8 T-lymphocytes identified by their CD28 and CD57 phenotypes. / 11-12.2015 / PubMed / Full text
Cutting edge: Central memory CD8 T cells in aged mice are virtual memory cells. / 15.12.2013 / PubMed / Full text
[[[CCR5]], CCR2, apoe, p53, ITGB3 and HFE gene polymorphism in Western Siberia long-livers]. / 2012 / PubMed

CDA

Cumulative Dis/Advantage and Health Pattern in Late Life: A Comparison between Genders and Welfare State Regimes. / 2019 / PubMed / Full text
Does numerical similarity alter age-related distractibility in working memory? / 2019 / PubMed / Full text
Can working memory capacity be expanded by boosting working memory updating efficiency in older adults? / 12.2018 / PubMed / Full text
Negative Affect Influences Electrophysiological Markers of Visual Working Memory in Mildly Stressed Older Adults. / 2018 / PubMed / Full text
EEG correlates of visual short-term memory in older age vary with adult lifespan cognitive development. / 02.2018 / PubMed / Full text
Mini dental assessment: a simple screening test for non-dental staff. / 06.2017 / PubMed / Full text
Electrophysiological Correlates of Subitizing in Healthy Aging. / 2015 / PubMed / Full text
Understanding age-related reductions in visual working memory capacity: examining the stages of change detection. / 10.2014 / PubMed / Full text
Retrospective attention enhances visual working memory in the young but not the old: an ERP study. / 05.2013 / PubMed / Full text

CTCF

New targeted approaches for epigenetic age predictions. / 24.06.2020 / PubMed / Full text
Blood DNA Methylation and Aging: A Cross-Sectional Analysis and Longitudinal Validation in the InCHIANTI Study. / 15.10.2020 / PubMed / Full text
In silico analysis of human renin gene-gene interactions and neighborhood topologically associated domains suggests breakdown of insulators contribute to ageing-associated diseases. / 12.2019 / PubMed / Full text
Genetic Insights Into Frailty: Association of 9p21-23 Locus With Frailty. / 2018 / PubMed / Full text
HMGB2 Loss upon Senescence Entry Disrupts Genomic Organization and Induces CTCF Clustering across Cell Types. / 17.05.2018 / PubMed / Full text
Polycomb repressive complex 2 epigenomic signature defines age-associated hypermethylation and gene expression changes. / 2015 / PubMed / Full text
Differential DNA methylation with age displays both common and dynamic features across human tissues that are influenced by CpG landscape. / 2013 / PubMed / Full text
Chromatin remodeling of human subtelomeres and TERRA promoters upon cellular senescence: commonalities and differences between chromosomes. / 05.2013 / PubMed / Full text
Long-lasting alterations to DNA methylation and ncRNAs could underlie the effects of fetal alcohol exposure in mice. / 07.2013 / PubMed / Full text

CXCL2

Cerebrovascular Senescence Is Associated With Tau Pathology in Alzheimer's Disease. / 2020 / PubMed / Full text
Inflammatory and Senescent Phenotype of Pancreatic Stellate Cells Induced by Sqstm1 Downregulation Facilitates Pancreatic Cancer Progression. / 2019 / PubMed / Full text
Long-term every-other-day administration of DMAMCL has little effect on aging and age-associated physiological decline in mice. / 02.05.2019 / PubMed / Full text
A Neutrophil Timer Coordinates Immune Defense and Vascular Protection. / 19.02.2019 / PubMed / Full text
Excessive neutrophil levels in the lung underlie the age-associated increase in influenza mortality. / 03.2019 / PubMed / Full text
Time-Dependent Changes in Local and Serum Levels of Inflammatory Cytokines as Markers for Incised Wound Aging of Skeletal Muscles. / 05.2018 / PubMed / Full text
Tumor microenvironment in functional adrenocortical adenomas: immune cell infiltration in cortisol-producing adrenocortical adenoma. / 07.2018 / PubMed / Full text
Palmitate promotes inflammatory responses and cellular senescence in cardiac fibroblasts. / 02.2017 / PubMed / Full text
Mice with heterozygous deficiency of manganese superoxide dismutase (SOD2) have a skin immune system with features of "inflamm-aging". / 03.2014 / PubMed / Full text

DBI

Quantifying cumulative anticholinergic and sedative drug load among US Medicare Beneficiaries. / 01.10.2020 / PubMed / Full text
Drug Burden Index and Cognitive and Physical Function in Aged Care Residents: A Longitudinal Study. / 08.2020 / PubMed / Full text
Using the Drug Burden Index to identify older adults at highest risk for medication-related falls. / 12.06.2020 / PubMed / Full text
Impact of STEADI-Rx: A Community Pharmacy-Based Fall Prevention Intervention. / 08.2020 / PubMed / Full text
Association of Drug Burden Index with grip strength, timed up and go and Barthel index activities of daily living in older adults with intellectual disabilities: an observational cross-sectional study. / 24.06.2019 / PubMed / Full text
Impact of drug burden index on adverse health outcomes in Irish community-dwelling older people: a cohort study. / 29.04.2019 / PubMed / Full text
Dietary Balance Index-07 and the Risk of Anemia in Middle Aged and Elderly People in Southwest China: A Cross Sectional Study. / 31.01.2018 / PubMed / Full text
Effects of Changes in Number of Medications and Drug Burden Index Exposure on Transitions Between Frailty States and Death: The Concord Health and Ageing in Men Project Cohort Study. / 01.2016 / PubMed / Full text
Drug Burden Index score and anticholinergic risk scale as predictors of readmission to the hospital. / 03.2014 / PubMed / Full text

DES

Increased circulating desmosine and age-dependent elastinolysis in idiopathic pulmonary fibrosis. / 20.03.2018 / PubMed / Full text
Genetic variation in low-dose effects of neonatal DES exposure in female rats. / 10.2017 / PubMed / Full text
Aging Eye Microbiota in Dry Eye Syndrome in Patients Treated with [i]Enterococcus faecium[/i] and [i]Saccharomyces boulardii[/i]. / 2017 / PubMed / Full text
The influence of advancing age on implantation of drug-eluting stents. / 10.2016 / PubMed / Full text
Calculating when elective abdominal aortic aneurysm repair improves survival for individual patients: development of the Aneurysm Repair Decision Aid and economic evaluation. / 04.2015 / PubMed / Full text
Diethylstilbestrol exposure in neonatal mice induces changes in the adulthood in the immune response to taenia crassiceps without modifications of parasite loads. / 2014 / PubMed / Full text
Androgen deficiency and dry eye syndrome in the aging male. / 03.07.2014 / PubMed / Full text
[[[DES]] Daughter--expertise remains necessary]. / 2013 / PubMed
Emotional reactivity assessment of healthy elderly with an emotion-induction procedure. / 2013 / PubMed / Full text

EDA

Interplay between aging, lung inflammation/remodeling, and fibronectin EDA in lung cancer progression. / 01.12.2020 / PubMed / Full text
Arousal Detection in Elderly People from Electrodermal Activity Using Musical Stimuli. / 25.08.2020 / PubMed / Full text
The structure of agricultural microplastics (PT, PU and UF) and their sorption capacities for PAHs and PHE derivates under various salinity and oxidation treatments. / 02.2020 / PubMed / Full text
Effect of storage on quality parameters and phenolic content of Italian extra-virgin olive oils. / 01.2020 / PubMed / Full text
Fibronectin Containing Extra Domain A Induces Plaque Destabilization in the Innominate Artery of Aged Apolipoprotein E-Deficient Mice. / 03.2018 / PubMed / Full text
An Extract from the Plant [i]Deschampsia antarctica[/i] Protects Fibroblasts from Senescence Induced by Hydrogen Peroxide. / 2017 / PubMed / Full text
Occurrence of fibronectin-fibrin complexes in plasma of patients with multimorbidity due to the inflamm-aging phenomenon. / 05.2016 / PubMed / Full text
Autonomic changes following generalized tonic clonic seizures: An analysis of adult and pediatric patients with epilepsy. / 09.2015 / PubMed / Full text
Error detection and error memory in spatial navigation as reflected by electrodermal activity. / 11.2013 / PubMed / Full text

FOXM1

Sirtuin 6 deficiency induces endothelial cell senescence via downregulation of forkhead box M1 expression. / 10.11.2020 / PubMed / Full text
Upregulation of FOXM1 leads to diminished drug sensitivity in myeloma. / 21.11.2018 / PubMed / Full text
Preclinical characterization of abemaciclib in hormone receptor positive breast cancer. / 19.09.2017 / PubMed / Full text
Age-dependent human β cell proliferation induced by glucagon-like peptide 1 and calcineurin signaling. / 02.10.2017 / PubMed / Full text
FOXM1 regulates proliferation, senescence and oxidative stress in keratinocytes and cancer cells. / 07.2016 / PubMed / Full text
MELK-T1, a small-molecule inhibitor of protein kinase MELK, decreases DNA-damage tolerance in proliferating cancer cells. / 02.10.2015 / PubMed / Full text
Increased FOXM1 expression can stimulate DNA repair in normal hepatocytes in vivo but also increases nuclear foci associated with senescence. / 02.2015 / PubMed / Full text
Cellular senescence and aging: the role of B-MYB. / 10.2014 / PubMed / Full text
MiR-506 suppresses proliferation and induces senescence by directly targeting the CDK4/6-FOXM1 axis in ovarian cancer. / 07.2014 / PubMed / Full text

GAA

Mitochondrial damage and senescence phenotype of cells derived from a novel frataxin G127V point mutation mouse model of Friedreich's ataxia. / 27.07.2020 / PubMed / Full text
Age-Related Changes in Serum Guanidinoacetic Acid in Women. / 30.12.2019 / PubMed / Full text
ALKB-8, a 2-Oxoglutarate-Dependent Dioxygenase and S-Adenosine Methionine-Dependent Methyltransferase Modulates Metabolic Events Linked to Lysosome-Related Organelles and Aging in C. elegans. / 2018 / PubMed
SIRT6 histone deacetylase functions as a potential oncogene in human melanoma. / 09.2017 / PubMed / Full text
Age and gender-specific reference intervals for lysosomal enzymes in dried blood spot samples: A study in Indian population. / 10.2017 / PubMed / Full text
Effects of guanidinoacetic acid diet supplementation on semen quality and fertility of broiler breeder roosters. / 02.2017 / PubMed / Full text
Effect of feeding guanidinoacetic acid and L-arginine on the fertility rate and sperm penetration in the perivitelline layer of aged broiler breeder hens. / 04.2016 / PubMed / Full text
Combined aerobic exercise and enzyme replacement therapy rejuvenates the mitochondrial-lysosomal axis and alleviates autophagic blockage in Pompe disease. / 10.2015 / PubMed / Full text
Dietary guanidino acetic acid is an efficacious replacement for arginine for young chicks. / 01.2013 / PubMed / Full text

GK

Progression of diabetic kidney disease in T2DN rats. / 01.12.2019 / PubMed / Full text
Reactive oxygen species-induced changes in glucose and lipid metabolism contribute to the accumulation of cholesterol in the liver during aging. / 04.2019 / PubMed / Full text
Age-Related Reduction of Contractile Responses to Urotensin II Is Seen in Aortas from Wistar Rats but Not from Type 2 Diabetic Goto-Kakizaki Rats. / 04.2017 / PubMed / Full text
[STUDY RELATIVE EXPRESSION OF GENES THAT CONTROL GLUCOSE METABOLISM IN THE LIVER IN MICE WITH DEVELOPMENT OF MELANOCORTIN OBESITY]. / 06.2015 / PubMed
Delta Cell Hyperplasia in Adult Goto-Kakizaki (GK/MolTac) Diabetic Rats. / 2015 / PubMed / Full text
Vascular, oxidative, and synaptosomal abnormalities during aging and the progression of type 2 diabetes. / 2014 / PubMed / Full text
Evidence for cortical neuronal loss in male type 2 diabetic Goto-Kakizaki rats. / 2014 / PubMed / Full text
Dietary resistant starch improves selected brain and behavioral functions in adult and aged rodents. / 11.2013 / PubMed / Full text
Decreased glucokinase protein expression in the aged gerbil hippocampus. / 05.2013 / PubMed / Full text

HDAC2

EEF1A1 deacetylation enables transcriptional activation of remyelination. / 09.07.2020 / PubMed / Full text
Endothelial toll-like receptor 4 maintains lung integrity via epigenetic suppression of p16 . / 06.2019 / PubMed / Full text
Budesonide, Aclidinium and Formoterol in combination limit inflammaging processes in bronchial epithelial cells exposed to cigarette smoke. / 04.2019 / PubMed / Full text
HDAC3 Regulates the Transition to the Homeostatic Myelinating Schwann Cell State. / 04.12.2018 / PubMed / Full text
Altered modulation of lamin A/C-HDAC2 interaction and p21 expression during oxidative stress response in HGPS. / 10.2018 / PubMed / Full text
Histone deacetylase 1 expression is inversely correlated with age in the short-lived fish Nothobranchius furzeri. / 09.2018 / PubMed / Full text
Histone Deacetylase 2 Inhibition Attenuates Downregulation of Hippocampal Plasticity Gene Expression during Aging. / 03.2018 / PubMed / Full text
Non-sirtuin histone deacetylases in the control of cardiac aging. / 06.2015 / PubMed / Full text
Histone deacetylase 2 in the mouse hippocampus: attenuation of age-related increase by caloric restriction. / 10.2013 / PubMed / Full text

IDH2

Oxidative Damage to the TCA Cycle Enzyme MDH1 Dysregulates Bioenergetic Enzymatic Activity in the Aged Murine Brain. / 03.04.2020 / PubMed / Full text
Reactive oxygen species-mediated senescence is accelerated by inhibiting Cdk2 in Idh2-deficient conditions. / 10.09.2019 / PubMed / Full text
Augmentation of cellular NAD by NQO1 enzymatic action improves age-related hearing impairment. / 10.2019 / PubMed / Full text
Improving Treatment for Myelodysplastic Syndromes Patients. / 25.10.2018 / PubMed / Full text
Loss of IDH2 Accelerates Age-related Hearing Loss in Male Mice. / 22.03.2018 / PubMed / Full text
IDH2-deficient mice develop spinal deformities with aging. / 17.07.2018 / PubMed / Full text
Idh2 deficiency accelerates renal dysfunction in aged mice. / 04.11.2017 / PubMed / Full text
IDH1 Associated with Neuronal Apoptosis in Adult Rats Brain Following Intracerebral Hemorrhage. / 07.2017 / PubMed / Full text
Epigenetic Aging Signatures Are Coherently Modified in Cancer. / 06.2015 / PubMed / Full text

IDS

Effect of immediate dentine sealing on the aging and fracture strength of lithium disilicate inlays and overlays. / 10.2020 / PubMed / Full text
Increased double limb support times during walking in right limb dominant healthy older adults with low bone density. / 06.2018 / PubMed / Full text
Comparison of two automated assays of BTM (CTX and P1NP) and reference intervals in a Danish population. / 07.2017 / PubMed / Full text
Metabolic dysregulation and late-life depression: a prospective study. / 04.2017 / PubMed / Full text
Total tooth loss and complete denture use in older adults with intellectual disabilities in Ireland. / Spring.2015 / PubMed / Full text
Depression in later life: a more somatic presentation? / 01.01.2015 / PubMed / Full text
Reference intervals for insulin-like growth factor-1 (igf-i) from birth to senescence: results from a multicenter study using a new automated chemiluminescence IGF-I immunoassay conforming to recent international recommendations. / 05.2014 / PubMed / Full text
Age- and sex-specific reference intervals across life span for insulin-like growth factor binding protein 3 (IGFBP-3) and the IGF-I to IGFBP-3 ratio measured by new automated chemiluminescence assays. / 05.2014 / PubMed / Full text
Transcriptomics of cortical gray matter thickness decline during normal aging. / 15.11.2013 / PubMed / Full text

ILK

Concurrent nicotine exposure to prenatal alcohol consumption alters the hippocampal and cortical neurotoxicity. / 01.2020 / PubMed / Full text
Age-dependent skeletal muscle transcriptome response to bed rest-induced atrophy. / 01.04.2019 / PubMed / Full text
Hyperphosphatemia Promotes Senescence of Myoblasts by Impairing Autophagy Through Ilk Overexpression, A Possible Mechanism Involved in Sarcopenia. / 10.2018 / PubMed / Full text
Integrin-linked kinase: A new actor in the ageing process? / 15.12.2017 / PubMed / Full text
Hyperphosphatemia induces cellular senescence in human aorta smooth muscle cells through integrin linked kinase (ILK) up-regulation. / 12.2015 / PubMed / Full text
Integrin-linked kinase regulates senescence in an Rb-dependent manner in cancer cell lines. / 2015 / PubMed / Full text
A dual role for integrin-linked kinase and β1-integrin in modulating cardiac aging. / 06.2014 / PubMed / Full text
Integrin-linked kinase modulates longevity and thermotolerance in C. elegans through neuronal control of HSF-1. / 06.2014 / PubMed / Full text
PPARβ/δ promotes HRAS-induced senescence and tumor suppression by potentiating p-ERK and repressing p-AKT signaling. / 13.11.2014 / PubMed / Full text

LAMP1

Resemblance and differences in dietary restriction nephroprotective mechanisms in young and old rats. / 24.09.2020 / PubMed / Full text
An In-Vitro Cell Model of Intracellular Protein Aggregation Provides Insights into RPE Stress Associated with Retinopathy. / 11.09.2020 / PubMed / Full text
Differential accumulation of storage bodies with aging defines discrete subsets of microglia in the healthy brain. / 24.06.2020 / PubMed / Full text
Yishen Huazhuo Decoction Induces Autophagy to Promote the Clearance of Aβ_1-42 in SAMP8 Mice: Mechanism Research of a Traditional Chinese Formula Against Alzheimer's Disease. / 2020 / PubMed / Full text
Dysregulations of mitochondrial quality control and autophagic flux at an early age lead to progression of sarcopenia in SAMP8 mice. / 06.2020 / PubMed / Full text
Deacetylation of LAMP1 drives lipophagy-dependent generation of free fatty acids by Abrus agglutinin to promote senescence in prostate cancer. / 03.2020 / PubMed / Full text
A pH probe inhibits senescence in mesenchymal stem cells. / 07.12.2018 / PubMed / Full text
Alterations in Corneal Sensory Nerves During Homeostasis, Aging, and After Injury in Mice Lacking the Heparan Sulfate Proteoglycan Syndecan-1. / 01.10.2017 / PubMed / Full text
Photoreceptor phagosome processing defects and disturbed autophagy in retinal pigment epithelium of Cln3Δex1-6 mice modelling juvenile neuronal ceroid lipofuscinosis (Batten disease). / 15.12.2015 / PubMed / Full text

LSS

Surgical results in older patients with lumbar spinal stenosis according to gait speed in relation to the diagnosis for sarcopenia. / 01-04.2020 / PubMed / Full text
Streamlining an existing hip fracture patient pathway in an acute tertiary adult Irish hospital to improve patient experience and outcomes. / 22.12.2019 / PubMed / Full text
Low-dose radiation from A-bombs elongated lifespan and reduced cancer mortality relative to un-irradiated individuals. / 2018 / PubMed / Full text
Lung, Laryngeal and Other Respiratory Cancer Incidence among Japanese Atomic Bomb Survivors: An Updated Analysis from 1958 through 2009. / 05.2017 / PubMed / Full text
Quantitating the lateral skin stiffness by a new and versatile electro-mechanical instrument. Preliminary studies. / 08.2017 / PubMed / Full text
A message to Fukushima: nothing to fear but fear itself. / 2016 / PubMed / Full text
Exposure to ionizing radiation and brain cancer incidence: The Life Span Study cohort. / 06.2016 / PubMed / Full text
Lumbar spondylosis, lumbar spinal stenosis, knee pain, back muscle strength are associated with the locomotive syndrome: Rural population study in Japan. / 05.2016 / PubMed / Full text
Does Obesity Affect Outcomes After Decompressive Surgery for Lumbar Spinal Stenosis? A Multicenter, Observational, Registry-Based Study. / 11.2015 / PubMed / Full text

MFI

The Influence of the Accelerated Aging Conditions on the Properties of Polyolefin Geogrids Used for Landfill Slope Reinforcement. / 20.08.2020 / PubMed / Full text
Changes in Physical Meat Traits, Protein Solubility, and the Microstructure of Different Beef Muscles during Post-Mortem Aging. / 19.06.2020 / PubMed / Full text
Effect of a low-voltage electrical stimulation on yak meat tenderness during postmortem aging. / 01-12.2020 / PubMed / Full text
Comparative effects of dry-aging and wet-aging on physicochemical properties and digestibility of Hanwoo beef. / 03.2020 / PubMed / Full text
Sexual dimorphism in rat thymic involution: a correlation with thymic oxidative status and inflammation. / 08.2019 / PubMed / Full text
Circulating soluble RAGE and cell surface RAGE on peripheral blood mononuclear cells in healthy children. / 27.06.2018 / PubMed / Full text
The frail fail: Increased mortality and post-operative complications in orthopaedic trauma patients. / 11.2017 / PubMed / Full text
Meat quality attributes of Agile Wallabies. / 11.2017 / PubMed / Full text
Phagocyte dysfunction in polymyalgia rheumatica and other age-related, chronic, inflammatory conditions. / 11.2013 / PubMed / Full text

MIA

TP53/miR-34a-associated signaling targets [i]SERPINE1[/i] expression in human pancreatic cancer. / 27.01.2020 / PubMed / Full text
Age, cohort, and period effects on metamemory beliefs. / 12.2019 / PubMed / Full text
Memory Age-based Stereotype Threat: Role of Locus of Control and Anxiety. / 01-02.2020 / PubMed / Full text
Lysyl Oxidase-Like 2 Protects against Progressive and Aging Related Knee Joint Osteoarthritis in Mice. / 27.09.2019 / PubMed / Full text
Role of melanoma inhibitory activity in melanocyte senescence. / 11.2019 / PubMed / Full text
Refining the metamemory in adulthood questionnaire: a 20-item version of change and capacity designed for research and clinical settings. / 07.2020 / PubMed / Full text
Maternal Immune Activation Alters Adult Behavior, Gut Microbiome and Juvenile Brain Oscillations in Ferrets. / 09-10.2018 / PubMed / Full text
Differential proteomic and oxidative profiles unveil dysfunctional protein import to adipocyte mitochondria in obesity-associated aging and diabetes. / 04.2017 / PubMed / Full text
Development of monosodium acetate-induced osteoarthritis and inflammatory pain in ageing mice. / 06.2015 / PubMed / Full text

MMD

Association between a Deficit Accumulation Frailty Index and Mobility Outcomes in Older Adults: Secondary Analysis of the Lifestyle Interventions and Independence for Elders (LIFE) Study. / 22.11.2020 / PubMed / Full text
Impact of Anticholinergic Medication Burden on Mobility and Falls in the Lifestyle Interventions for Elders (LIFE) Study. / 16.09.2020 / PubMed / Full text
Impact and Lessons From the Lifestyle Interventions and Independence for Elders (LIFE) Clinical Trials of Physical Activity to Prevent Mobility Disability. / 04.2020 / PubMed / Full text
Lactobacillus rescues postnatal neurobehavioral and microglial dysfunction in a model of maternal microbiome dysbiosis. / 10.2019 / PubMed / Full text
A Case for Promoting Movement Medicine: Preventing Disability in the LIFE Randomized Controlled Trial. / 04.10.2019 / PubMed / Full text
Determinants of Basal Collaterals in Moyamoya Disease: Clinical and Genetic Factors. / 2016 / PubMed / Full text
Antihypertensive Use and the Effect of a Physical Activity Intervention in the Prevention of Major Mobility Disability Among Older Adults: The LIFE Study. / 07.2016 / PubMed / Full text
Perfusion characteristics of Moyamoya disease: an anatomically and clinically oriented analysis and comparison. / 01.2014 / PubMed / Full text
Do older patients find multi-compartment medication devices easy to use and which are the easiest? / 11.2013 / PubMed / Full text

MRE11

TPP1 Enhances the Therapeutic Effects of Transplanted Aged Mesenchymal Stem Cells in Infarcted Hearts via the MRE11/AKT Pathway. / 2020 / PubMed / Full text
Chromosomal alterations among age-related haematopoietic clones in Japan. / 08.2020 / PubMed / Full text
ATM Deficiency Accelerates DNA Damage, Telomere Erosion, and Premature T Cell Aging in HIV-Infected Individuals on Antiretroviral Therapy. / 2019 / PubMed / Full text
Mechanistic link between DNA damage sensing, repairing and signaling factors and immune signaling. / 2019 / PubMed / Full text
The activated DNA double-strand break repair pathway in cumulus cells from aging patients may be used as a convincing predictor of poor outcomes after in vitro fertilization-embryo transfer treatment. / 2018 / PubMed / Full text
Transactivation domain of p53 regulates DNA repair and integrity in human iPS cells. / 01.09.2018 / PubMed / Full text
BRCA-1 Gene Expression and Comparative Proteomic Profile of Primordial Follicles from Young and Adult Buffalo (Bubalus bubalis) Ovaries. / 03.04.2017 / PubMed / Full text
NBS1 is required for macrophage homeostasis and functional activity in mice. / 26.11.2015 / PubMed / Full text
Impairment of BRCA1-related DNA double-strand break repair leads to ovarian aging in mice and humans. / 13.02.2013 / PubMed / Full text

MSTN

Age- and stage-dependent variations of muscle-specific gene expression in brown trout Salmo trutta L. / 09.2017 / PubMed / Full text
Activity of metabolic enzymes and muscle-specific gene expression in parr and smolts Atlantic salmon Salmo salar L. of different age groups. / 08.2017 / PubMed / Full text
miR-30e is negatively regulated by myostatin in skeletal muscle and is functionally related to fiber-type composition. / 01.05.2017 / PubMed / Full text
Muscle-Related Polymorphisms (MSTN rs1805086 and ACTN3 rs1815739) Are Not Associated with Exceptional Longevity in Japanese Centenarians. / 2016 / PubMed / Full text
Temporal and spatial expression of Smads and their correlation with YAP1 expression in sheep. / 26.08.2016 / PubMed / Full text
Quantification of GDF11 and Myostatin in Human Aging and Cardiovascular Disease. / 14.06.2016 / PubMed / Full text
Morphological analysis and muscle-associated gene expression during different muscle growth phases of Megalobrama amblycephala. / 28.09.2015 / PubMed / Full text
The effect of exercise mode on the acute response of satellite cells in old men. / 12.2015 / PubMed / Full text
Association of the K153R polymorphism in the myostatin gene and extreme longevity. / 12.2013 / PubMed / Full text

PNN

Hyaluronan degradation and release of a hyaluronan-aggrecan complex from perineuronal nets in the aged mouse brain. / 28.11.2020 / PubMed / Full text
Maturation of PNN and ErbB4 Signaling in Area CA2 during Adolescence Underlies the Emergence of PV Interneuron Plasticity and Social Memory. / 29.10.2019 / PubMed / Full text
Inhibition of Semaphorin3A Promotes Ocular Dominance Plasticity in the Adult Rat Visual Cortex. / 09.2019 / PubMed / Full text
Proteomics and metabolomics identify molecular mechanisms of aging potentially predisposing for chronic lymphocytic leukemia. / 02.2018 / PubMed / Full text
Age-dependent and region-specific alteration of parvalbumin neurons and perineuronal nets in the mouse cerebral cortex. / 01.2018 / PubMed / Full text
Brain ageing changes proteoglycan sulfation, rendering perineuronal nets more inhibitory. / 28.06.2017 / PubMed / Full text
Removal of Perineuronal Nets Unlocks Juvenile Plasticity Through Network Mechanisms of Decreased Inhibition and Increased Gamma Activity. / 01.02.2017 / PubMed / Full text
Age-Related Deterioration of Perineuronal Nets in the Primary Auditory Cortex of Mice. / 2016 / PubMed / Full text
Spatio-temporal differences in perineuronal net expression in the mouse hippocampus, with reference to parvalbumin. / 03.12.2013 / PubMed / Full text

POLG

Maternal ageing impairs mitochondrial DNA kinetics during early embryogenesis in mice. / 08.07.2019 / PubMed / Full text
Parkin does not prevent accelerated cardiac aging in mitochondrial DNA mutator mice. / 16.04.2019 / PubMed / Full text
The effects of AICAR and rapamycin on mitochondrial function in immortalized mitochondrial DNA mutator murine embryonic fibroblasts. / 16.11.2018 / PubMed / Full text
Impact of exercise on oocyte quality in the POLG mitochondrial DNA mutator mouse. / 08.2018 / PubMed / Full text
The role of sodium hydrosulfide in attenuating the aging process via PI3K/AKT and CaMKKβ/AMPK pathways. / 08.2017 / PubMed / Full text
Metabolomic analysis of exercise effects in the POLG mitochondrial DNA mutator mouse brain. / 11.2015 / PubMed / Full text
Mitochondria DNA mutations cause sex-dependent development of hypertension and alterations in cardiovascular function. / 05.02.2015 / PubMed / Full text
Somatic mitochondrial DNA mutations do not increase neuronal vulnerability to MPTP in young POLG mutator mice. / 11-12.2014 / PubMed / Full text
The impact of pathogenic mitochondrial DNA mutations on substantia nigra neurons. / 26.06.2013 / PubMed / Full text

RAD51

53BP1 Enforces Distinct Pre- and Post-resection Blocks on Homologous Recombination. / 02.01.2020 / PubMed / Full text
Loss of Slug Compromises DNA Damage Repair and Accelerates Stem Cell Aging in Mammary Epithelium. / 09.07.2019 / PubMed / Full text
Quantitative assessment of changes in cell growth, size and morphology during telomere-initiated cellular senescence in Saccharomyces cerevisiae. / 01.08.2019 / PubMed / Full text
Mechanistic link between DNA damage sensing, repairing and signaling factors and immune signaling. / 2019 / PubMed / Full text
The activated DNA double-strand break repair pathway in cumulus cells from aging patients may be used as a convincing predictor of poor outcomes after in vitro fertilization-embryo transfer treatment. / 2018 / PubMed / Full text
Artesunate enhances the therapeutic response of glioma cells to temozolomide by inhibition of homologous recombination and senescence. / 11.10.2016 / PubMed / Full text
BRCA-1 Gene Expression and Comparative Proteomic Profile of Primordial Follicles from Young and Adult Buffalo (Bubalus bubalis) Ovaries. / 03.04.2017 / PubMed / Full text
SQSTM1/p62 mediates crosstalk between autophagy and the UPS in DNA repair. / 02.10.2016 / PubMed / Full text
RECQL5 has unique strand annealing properties relative to the other human RecQ helicase proteins. / 01.2016 / PubMed / Full text

SMAD2

Effects of Tenascin C on the Integrity of Extracellular Matrix and Skin Aging. / 18.11.2020 / PubMed / Full text
The effects and mechanism of collagen peptide and elastin peptide on skin aging induced by D-galactose combined with ultraviolet radiation. / 09.2020 / PubMed / Full text
Prostate epithelial-specific expression of activated PI3K drives stromal collagen production and accumulation. / 02.2020 / PubMed / Full text
Restoring extracellular matrix synthesis in senescent stem cells. / 10.2019 / PubMed / Full text
iTRAQ-based proteomic profiling of granulosa cells from lamb and ewe after superstimulation. / 01.10.2017 / PubMed / Full text
Exogenous GDF11 induces cardiac and skeletal muscle dysfunction and wasting. / 07.2017 / PubMed / Full text
Circulating Growth Differentiation Factor 11/8 Levels Decline With Age. / 08.01.2016 / PubMed / Full text
Effects of aging on cardiac extracellular matrix in men and women. / 01.2016 / PubMed / Full text
Age-associated changes in gene expression of goat oocytes. / 01.09.2013 / PubMed / Full text

SON

Absence of axonal sprouting following unilateral lesion in 125-day-old rat supraoptic nucleus may be due to age-dependent decrease in protein levels of ciliary neurotrophic factor receptor alpha. / 01.10.2019 / PubMed / Full text
Neural Mechanisms Involved in the Noxious Physical Stress-Induced Inhibition of Ovarian Estradiol Secretion. / 06.2019 / PubMed / Full text
Aging affects isoproterenol-induced water drinking, astrocyte density, and central neuronal activation in female Brown Norway rats. / 01.08.2018 / PubMed / Full text
The effects of aging on biosynthetic processes in the rat hypothalamic osmoregulatory neuroendocrine system. / 05.2018 / PubMed / Full text
Increased oxytocin-monomeric red fluorescent protein 1 fluorescent intensity with urocortin-like immunoreactivity in the hypothalamo-neurohypophysial system of aged transgenic rats. / 03.2018 / PubMed / Full text
Age-Related (Aged vs. Adult) Comparison of the Effect of Two Mild Stressors on the Nerve Growth Factor (NGF) in the Rat Hypothalamic Supraoptic Nucleus (SON) - Immunohistochemical Study. / 2016 / PubMed
Exposure to mild stress and brain derived neurotrophin factor (BDNF) immunoreactivity in the hypothalamic paraventricular (PVN) and supraoptic (SON) nuclei: Comparison between aged and adult rats. / 12.2016 / PubMed / Full text
Testing the critical window of estradiol replacement on gene expression of vasopressin, oxytocin, and their receptors, in the hypothalamus of aging female rats. / 05.01.2016 / PubMed / Full text
[Lamellar complex changes in the human basal forebrain and hypothalamic nuclei neurons in different age groups]. / 2014 / PubMed

SQSTM1

The selective autophagy receptor SQSTM1/p62 improves lifespan and proteostasis in an evolutionarily conserved manner. / 04.2020 / PubMed / Full text
SQSTM1/p62 and PPARGC1A/PGC-1alpha at the interface of autophagy and vascular senescence. / 06.2020 / PubMed / Full text
SIRT2 functions in aging, autophagy, and apoptosis in post-maturation bovine oocytes. / 01.09.2019 / PubMed / Full text
A pH probe inhibits senescence in mesenchymal stem cells. / 07.12.2018 / PubMed / Full text
The ATG5-binding and coiled coil domains of ATG16L1 maintain autophagy and tissue homeostasis in mice independently of the WD domain required for LC3-associated phagocytosis. / 04.2019 / PubMed / Full text
Systemic overexpression of SQSTM1/p62 accelerates disease onset in a SOD1 -expressing ALS mouse model. / 29.05.2018 / PubMed / Full text
SIRT6 histone deacetylase functions as a potential oncogene in human melanoma. / 09.2017 / PubMed / Full text
SQSTM1/p62 mediates crosstalk between autophagy and the UPS in DNA repair. / 02.10.2016 / PubMed / Full text
Defective autophagy in vascular smooth muscle cells accelerates senescence and promotes neointima formation and atherogenesis. / 02.11.2015 / PubMed / Full text

VHL

Hypoxic response regulators RHY-1 and EGL-9/PHD promote longevity through a VHL-1-independent transcriptional response. / 12.2020 / PubMed / Full text
The Energy Maintenance Theory of Aging: Maintaining Energy Metabolism to Allow Longevity. / 08.2018 / PubMed / Full text
Shorter telomere length increases age-related tumor risks in von Hippel-Lindau disease patients. / 09.2017 / PubMed / Full text
Biological and clinical impact of hemangioblastoma-associated peritumoral cysts in von Hippel-Lindau disease. / 04.2016 / PubMed / Full text
Long-term prognosis of patients with pediatric pheochromocytoma. / 02.2014 / PubMed / Full text
Inactivation of Vhl in osteochondral progenitor cells causes high bone mass phenotype and protects against age-related bone loss in adult mice. / 04.2014 / PubMed / Full text
Senescence-associated protein p400 is a prognostic marker in renal cell carcinoma. / 11.2013 / PubMed / Full text
E2F1 in renal cancer: Mr Hyde disguised as Dr Jekyll? / 10.2013 / PubMed / Full text
Loss of the Birt-Hogg-Dubé gene product folliculin induces longevity in a hypoxia-inducible factor-dependent manner. / 08.2013 / PubMed / Full text

VWF

Von Willebrand disease in the elderly: clinical perspectives. / 2018 / PubMed / Full text
Comorbidities associated with higher von Willebrand factor (VWF) levels may explain the age-related increase of VWF in von Willebrand disease. / 07.2018 / PubMed / Full text
The Association of Aging With Von Willebrand Factor Levels and Bleeding Risk in Type 1 Von Willebrand Disease. / 04.2018 / PubMed / Full text
Aging and ABO blood type influence von Willebrand factor and factor VIII levels through interrelated mechanisms. / 05.2016 / PubMed / Full text
Age-related changes in platelet function are more profound in women than in men. / 16.07.2015 / PubMed / Full text
Von Willebrand factor and aging. / 09.2014 / PubMed / Full text
Aging hemostasis: changes to laboratory markers of hemostasis as we age - a narrative review. / 09.2014 / PubMed / Full text
von Willebrand disease and aging: an evolving phenotype. / 07.2014 / PubMed / Full text
Age-related changes in aortic valve hemostatic protein regulation. / 01.2014 / PubMed / Full text

XIAP

Directed elimination of senescent cells attenuates development of osteoarthritis by inhibition of c-IAP and XIAP. / 01.10.2019 / PubMed / Full text
Modulated electro-hyperthermia induced p53 driven apoptosis and cell cycle arrest additively support doxorubicin chemotherapy of colorectal cancer in vitro. / 08.2019 / PubMed / Full text
Protective effect of xanthohumol against age-related brain damage. / 11.2017 / PubMed / Full text
Molecular modeling in the age of clinical genomics, the enterprise of the next generation. / 03.2017 / PubMed / Full text
Sperm-associated antigen 9 (SPAG9) promotes the survival and tumor growth of triple-negative breast cancer cells. / 10.2016 / PubMed / Full text
XIAP-associating factor 1, a transcriptional target of BRD7, contributes to endothelial cell senescence. / 02.02.2016 / PubMed / Full text
Targeting protein neddylation with an NEDD8-activating enzyme inhibitor MLN4924 induced apoptosis or senescence in human lymphoma cells. / 2015 / PubMed / Full text
Increase in retinal ganglion cells' susceptibility to elevated intraocular pressure and impairment of their endogenous neuroprotective mechanism by age. / 2013 / PubMed / Full text
The member of high temperature requirement family HtrA2 participates in neuronal apoptosis after intracerebral hemorrhage in adult rats. / 08.2013 / PubMed / Full text

YAP1

Loss of Wasl improves pancreatic cancer outcome. / 21.05.2020 / PubMed / Full text
Treatment-Induced Tumor Dormancy through YAP-Mediated Transcriptional Reprogramming of the Apoptotic Pathway. / 13.01.2020 / PubMed / Full text
Effects of age-dependent changes in cell size on endothelial cell proliferation and senescence through YAP1. / 05.09.2019 / PubMed / Full text
[Expression relationship of Hippo signaling molecules and ovarian germline stem cell markers in the ovarian aging process of women and mice]. / 25.06.2019 / PubMed
YAP1-LATS2 feedback loop dictates senescent or malignant cell fate to maintain tissue homeostasis. / 03.2019 / PubMed / Full text
Extended Multiplexing of Tandem Mass Tags (TMT) Labeling Reveals Age and High Fat Diet Specific Proteome Changes in Mouse Epididymal Adipose Tissue. / 05.2017 / PubMed / Full text
Impaired liver regeneration in aged mice can be rescued by silencing Hippo core kinases MST1 and MST2. / 01.2017 / PubMed / Full text
Temporal and spatial expression of Smads and their correlation with YAP1 expression in sheep. / 26.08.2016 / PubMed / Full text
Causal mechanisms and balancing selection inferred from genetic associations with polycystic ovary syndrome. / 29.09.2015 / PubMed / Full text

ABCA1

Intracellular cholesterol stimulates ENaC by interacting with phosphatidylinositol‑4,5‑bisphosphate and mediates cyclosporine A-induced hypertension. / 01.07.2019 / PubMed / Full text
Disrupted cholesterol metabolism promotes age-related photoreceptor neurodegeneration. / 08.2018 / PubMed / Full text
Advanced glycation end products affect cholesterol homeostasis by impairing ABCA1 expression on macrophages. / 08.2017 / PubMed / Full text
Genome-wide DNA methylation profiles reveal novel candidate genes associated with meat quality at different age stages in hens. / 05.04.2017 / PubMed / Full text
Impact of age and sex on the development of atherosclerosis and expression of the related genes in apoE deficient mice. / 15.01.2016 / PubMed / Full text
Dynamic changes of Apo A1 mediated by LXR/RXR/ABCA1 pathway in brains of the aging rats with cerebral hypoperfusion. / 01.2014 / PubMed / Full text
Elevated COX2 expression and PGE2 production by downregulation of RXRα in senescent macrophages. / 11.10.2013 / PubMed / Full text
Genetic determinants of macular pigments in women of the Carotenoids in Age-Related Eye Disease Study. / 28.03.2013 / PubMed / Full text

ACTN3

Altered miRNA and mRNA Expression in Sika Deer Skeletal Muscle with Age. / 06.02.2020 / PubMed / Full text
The Role of Genetic Profile in Functional Performance Adaptations to Exercise Training or Physical Activity: A Systematic Review of the Literature. / 01.08.2019 / PubMed / Full text
Is evolutionary loss our gain? The role of ACTN3 p.Arg577Ter (R577X) genotype in athletic performance, ageing, and disease. / 12.2018 / PubMed / Full text
ACTN3 genotype and physical function and frailty in an elderly Chinese population: the Rugao Longevity and Ageing Study. / 01.05.2018 / PubMed / Full text
Muscle-Related Polymorphisms (MSTN rs1805086 and ACTN3 rs1815739) Are Not Associated with Exceptional Longevity in Japanese Centenarians. / 2016 / PubMed / Full text
Genetic variation and exercise-induced muscle damage: implications for athletic performance, injury and ageing. / 09.2016 / PubMed / Full text
The ACTN3 R577X genotype is associated with muscle function in a Japanese population. / 04.2015 / PubMed / Full text
1000 Norms Project: protocol of a cross-sectional study cataloging human variation. / 03.2016 / PubMed / Full text

ASXL1

Aging and leukemic evolution of hematopoietic stem cells under various stress conditions. / 05.11.2020 / PubMed / Full text
60 Years of clonal hematopoiesis research: From X-chromosome inactivation studies to the identification of driver mutations. / 03.2020 / PubMed / Full text
ASXL1 mutation in clonal hematopoiesis. / 03.2020 / PubMed / Full text
Clonal haematopoiesis: connecting ageing and inflammation in cardiovascular disease. / 03.2020 / PubMed / Full text
[Role of ASXL1 mutations in hematological disorders]. / 2019 / PubMed / Full text
Clonal hematopoiesis: Genes and underlying mechanisms in cardiovascular disease development. / 06.2019 / PubMed / Full text
A primer for epigenetics of hematological malignancies. / 2016 / PubMed / Full text
The BAP1/ASXL2 Histone H2A Deubiquitinase Complex Regulates Cell Proliferation and Is Disrupted in Cancer. / 27.11.2015 / PubMed / Full text

B2M

Accelerated Epigenetic Aging and Methylation Disruptions Occur in Human Immunodeficiency Virus Infection Prior to Antiretroviral Therapy. / 22.09.2020 / PubMed / Full text
The relationships between markers of tubular injury and intrarenal haemodynamic function in adults with and without type 1 diabetes: Results from the Canadian Study of Longevity in Type 1 Diabetes. / 03.2019 / PubMed / Full text
Association between serum β2-microglobulin levels and frailty in an elderly Chinese population: results from RuLAS. / 2017 / PubMed / Full text
Non-GFR Determinants of Low-Molecular-Weight Serum Protein Filtration Markers in the Elderly: AGES-Kidney and MESA-Kidney. / 09.2017 / PubMed / Full text
Association Between Serum β -Microglobulin Levels and Prevalent and Incident Physical Frailty in Community-Dwelling Older Women. / 04.2017 / PubMed / Full text
A single heterochronic blood exchange reveals rapid inhibition of multiple tissues by old blood. / 22.11.2016 / PubMed / Full text
β2-microglobulin is a systemic pro-aging factor that impairs cognitive function and neurogenesis. / 08.2015 / PubMed / Full text
Systemic attenuation of the TGF-β pathway by a single drug simultaneously rejuvenates hippocampal neurogenesis and myogenesis in the same old mammal. / 20.05.2015 / PubMed / Full text

BIN1

Amphiphysin 2 modulation rescues myotubular myopathy and prevents focal adhesion defects in mice. / 20.03.2019 / PubMed / Full text
Recent studies on cellular and molecular mechanisms in Alzheimer's disease: focus on epigenetic factors and histone deacetylase. / 28.03.2018 / PubMed / Full text
Association and interaction effects of Alzheimer's disease-associated genes and lifestyle on cognitive aging in older adults in a Taiwanese population. / 11.04.2017 / PubMed / Full text
Dopamine Receptor Genes Modulate Associative Memory in Old Age. / 02.2017 / PubMed / Full text
Gene-based aggregate SNP associations between candidate AD genes and cognitive decline. / 04.2016 / PubMed / Full text
Association of Alzheimer's disease GWAS loci with MRI markers of brain aging. / 04.2015 / PubMed / Full text
The benefits of staying active in old age: physical activity counteracts the negative influence of PICALM, BIN1, and CLU risk alleles on episodic memory functioning. / 06.2014 / PubMed / Full text
BIN1 is decreased in sporadic but not familial Alzheimer's disease or in aging. / 2013 / PubMed / Full text

BMP4

Direct reprogramming of human smooth muscle and vascular endothelial cells reveals defects associated with aging and Hutchinson-Gilford progeria syndrome. / 08.09.2020 / PubMed / Full text
Interplay between Follistatin, Activin A, and BMP4 Signaling Regulates Postnatal Thymic Epithelial Progenitor Cell Differentiation during Aging. / 25.06.2019 / PubMed / Full text
Centenarians Overexpress Pluripotency-Related Genes. / 16.08.2019 / PubMed / Full text
BMP-SMAD-ID promotes reprogramming to pluripotency by inhibiting p16/INK4A-dependent senescence. / 15.11.2016 / PubMed / Full text
Increased bone morphogenetic protein signaling contributes to age-related declines in neurogenesis and cognition. / 02.2016 / PubMed / Full text
Control of the Normal and Pathological Development of Neural Stem and Progenitor Cells by the PC3/Tis21/Btg2 and Btg1 Genes. / 12.2015 / PubMed / Full text
FSH-FSHR3-stem cells in ovary surface epithelium: basis for adult ovarian biology, failure, aging, and cancer. / 01.2015 / PubMed / Full text
Molecular cloning and expression analysis of prostaglandin E receptor 2 gene in cashmere goat (Capra hircus) skin during hair follicle development. / 03.04.2014 / PubMed / Full text

C9

C9orf72 in myeloid cells suppresses STING-induced inflammation. / 09.2020 / PubMed / Full text
Glycine-alanine dipeptide repeats spread rapidly in a repeat length- and age-dependent manner in the fly brain. / 16.12.2019 / PubMed / Full text
Human iPSC-derived astrocytes from ALS patients with mutated C9ORF72 show increased oxidative stress and neurotoxicity. / 12.2019 / PubMed / Full text
Age and Sex-Associated Changes of Complement Activity and Complement Levels in a Healthy Caucasian Population. / 2018 / PubMed / Full text
TMT-Based Quantitative Proteomic Analysis Reveals Proteomic Changes Involved in Longevity. / 07.2019 / PubMed / Full text
C9orf72 Dipeptide Repeats Cause Selective Neurodegeneration and Cell-Autonomous Excitotoxicity in [i]Drosophila[/i] Glutamatergic Neurons. / 29.08.2018 / PubMed / Full text
Extended Multiplexing of Tandem Mass Tags (TMT) Labeling Reveals Age and High Fat Diet Specific Proteome Changes in Mouse Epididymal Adipose Tissue. / 05.2017 / PubMed / Full text
Rare variants in CFI, C3 and C9 are associated with high risk of advanced age-related macular degeneration. / 11.2013 / PubMed / Full text

CCL4

Microglial translational profiling reveals a convergent APOE pathway from aging, amyloid, and tau. / 03.09.2018 / PubMed / Full text
Time-Dependent Changes in Local and Serum Levels of Inflammatory Cytokines as Markers for Incised Wound Aging of Skeletal Muscles. / 05.2018 / PubMed / Full text
Human Body Composition and Immunity: Visceral Adipose Tissue Produces IL-15 and Muscle Strength Inversely Correlates with NK Cell Function in Elderly Humans. / 2018 / PubMed / Full text
Age-related pro-inflammatory and pro-angiogenic changes in human aqueous humor. / 2018 / PubMed / Full text
Age-related decline of the acute local inflammation response: a mitigating role for the adenosine A receptor. / 18.10.2017 / PubMed / Full text
Simultaneous time course analysis of multiple markers based on DNA microarray in incised wound in skeletal muscle for wound aging. / 09.2016 / PubMed / Full text
Changes in the expression of the Toll-like receptor system in the aging rat kidneys. / 2014 / PubMed / Full text
Age-related brain expression and regulation of the chemokine CCL4/MIP-1β in APP/PS1 double-transgenic mice. / 04.2014 / PubMed / Full text

CDK5

Age-related hyperinsulinemia leads to insulin resistance in neurons and cell-cycle-induced senescence. / 11.2019 / PubMed / Full text
CK2 inhibition protects white matter from ischemic injury. / 20.11.2018 / PubMed / Full text
CK2 inhibition confers functional protection to young and aging axons against ischemia by differentially regulating the CDK5 and AKT signaling pathways. / 06.2019 / PubMed / Full text
The pathological roles of NDRG2 in Alzheimer's disease, a study using animal models and APPwt-overexpressed cells. / 08.2017 / PubMed / Full text
APOE4 Induces Site-Specific Tau Phosphorylation Through Calpain-CDK5 Signaling Pathway in EFAD-Tg Mice. / 2016 / PubMed / Full text
GENETICS OF HUMAN AGE RELATED DISORDERS. / 2015 / PubMed
Surgical stress induces brain-derived neurotrophic factor reduction and postoperative cognitive dysfunction via glucocorticoid receptor phosphorylation in aged mice. / 05.2015 / PubMed / Full text
Loss-of-SIRT1 function during vascular ageing: hyperphosphorylation mediated by cyclin-dependent kinase 5. / 02.2014 / PubMed / Full text

COL1A1

The effect of aging on the biological and immunological characteristics of periodontal ligament stem cells. / 29.07.2020 / PubMed / Full text
Remodeling process in bone of aged rats in response to resistance training. / 01.09.2020 / PubMed / Full text
Diet enrichment with a specific essential free amino acid mixture improves healing of undressed wounds in aged rats. / 01.10.2017 / PubMed / Full text
Sirtuin 7 is decreased in pulmonary fibrosis and regulates the fibrotic phenotype of lung fibroblasts. / 01.06.2017 / PubMed / Full text
Scleraxis Is Essential for Tendon Differentiation by Equine Embryonic Stem Cells and in Equine Fetal Tenocytes. / 15.03.2017 / PubMed / Full text
The comparison of microRNA profile of the dermis between the young and elderly. / 05.2016 / PubMed / Full text
Molecular differences between stromal cell populations from deciduous and permanent human teeth. / 18.04.2015 / PubMed / Full text
Relationship of age and body mass index to the expression of obesity and osteoarthritis-related genes in human meniscus. / 09.2013 / PubMed / Full text

COMP

Effect of circadian rhythm, age, training and acute lameness on serum concentrations of cartilage oligomeric matrix protein (COMP) neo-epitope in horses. / 09.2019 / PubMed / Full text
Genetic overexpression of COMP-Ang1 impairs BM microenvironment and induces senescence of BM HSCs. / 15.05.2018 / PubMed / Full text
Longitudinal Twin Study of Subjective Health: Differences in Genetic and Environmental Components of Variance Across Age and Sex. / 01.01.2020 / PubMed / Full text
Cartilage biomarkers in the osteoarthropathy of alkaptonuria reveal low turnover and accelerated ageing. / 01.2017 / PubMed / Full text
Scleraxis Is Essential for Tendon Differentiation by Equine Embryonic Stem Cells and in Equine Fetal Tenocytes. / 15.03.2017 / PubMed / Full text
Cartilage oligomeric matrix protein prevents vascular aging and vascular smooth muscle cells senescence. / 16.09.2016 / PubMed / Full text
Fibrotic-like changes in degenerate human intervertebral discs revealed by quantitative proteomic analysis. / 03.2016 / PubMed / Full text
Enhanced tissue regeneration potential of juvenile articular cartilage. / 11.2013 / PubMed / Full text

CYP1A2

Age-associated changes of cytochrome P450 and related phase-2 gene/proteins in livers of rats. / 2019 / PubMed / Full text
Impact of Ethnicity-Specific Hepatic Microsomal Scaling Factor, Liver Weight, and Cytochrome P450 (CYP) 1A2 Content on Physiologically Based Prediction of CYP1A2-Mediated Pharmacokinetics in Young and Elderly Chinese Adults. / 07.2019 / PubMed / Full text
Pediatric Cytochrome P450 Activity Alterations in Nonalcoholic Steatohepatitis. / 12.2017 / PubMed / Full text
Analysis of the variability of the pharmacokinetics of multiple drugs in young adult and elderly subjects and its implications for acceptable daily exposures and cleaning validation limits. / 06.2017 / PubMed / Full text
Determination of Human Hepatic CYP2C8 and CYP1A2 Age-Dependent Expression to Support Human Health Risk Assessment for Early Ages. / 05.2017 / PubMed / Full text
Prediction of serum theophylline concentrations and cytochrome P450 1A2 activity by analyzing urinary metabolites in preterm infants. / 06.2017 / PubMed / Full text
[Age-dependent CYP1A2 gene polymorphism -163C>A in three ethnic groups of Bashkortostan Republic residents]. / 2014 / PubMed
Age-related changes in hepatic activity and expression of detoxification enzymes in male rats. / 2013 / PubMed / Full text

CYP2C19

Physiologically Based Pharmacokinetic Approach Can Successfully Predict Pharmacokinetics of Citalopram in Different Patient Populations. / 04.2020 / PubMed / Full text
Longitudinal exposure of English primary care patients to pharmacogenomic drugs: An analysis to inform design of pre-emptive pharmacogenomic testing. / 12.2019 / PubMed / Full text
The safety, tolerability and pharmacokinetics of BI 409306, a novel and potent PDE9 inhibitor: Overview of three Phase I randomised trials in healthy volunteers. / 05.2018 / PubMed / Full text
Pediatric Cytochrome P450 Activity Alterations in Nonalcoholic Steatohepatitis. / 12.2017 / PubMed / Full text
Analysis of the variability of the pharmacokinetics of multiple drugs in young adult and elderly subjects and its implications for acceptable daily exposures and cleaning validation limits. / 06.2017 / PubMed / Full text
Determination of Human Hepatic CYP2C8 and CYP1A2 Age-Dependent Expression to Support Human Health Risk Assessment for Early Ages. / 05.2017 / PubMed / Full text
Identifying clinically relevant sources of variability: The clopidogrel challenge. / 02.2017 / PubMed / Full text
Impact of age on serum concentrations of venlafaxine and escitalopram in different CYP2D6 and CYP2C19 genotype subgroups. / 08.2014 / PubMed / Full text

DCN

Decorin inhibits the insulin-like growth factor I signaling in bone marrow mesenchymal stem cells of aged humans. / 26.11.2020 / PubMed / Full text
Classification of neurons in the adult mouse cochlear nucleus: Linear discriminant analysis. / 2019 / PubMed / Full text
The beneficial effects of 15 units of high-intensity circuit training in women is modified by age, baseline insulin resistance and physical capacity. / 06.2019 / PubMed / Full text
MicroRNA-143-5p targeting eEF2 gene mediates intervertebral disc degeneration through the AMPK signaling pathway. / 15.04.2019 / PubMed / Full text
Does Age Interfere With Gadolinium Toxicity and Presence in Brain and Bone Tissues?: A Comparative Gadoterate Versus Gadodiamide Study in Juvenile and Adult Rats. / 02.2019 / PubMed / Full text
Extracellular proteoglycan decorin maintains human hair follicle stem cells. / 12.2018 / PubMed / Full text
Synaptic Specializations Support Frequency-Independent Purkinje Cell Output from the Cerebellar Cortex. / 20.12.2016 / PubMed / Full text
The aging human cochlear nucleus: Changes in the glial fibrillary acidic protein, intracellular calcium regulatory proteins, GABA neurotransmitter and cholinergic receptor. / 03.2014 / PubMed / Full text

DNMT3B

Collagens and DNA methyltransferases in mare endometrosis. / 09.2019 / PubMed / Full text
Alcohol Extracts From [i]Ganoderma lucidum[/i] Delay the Progress of Alzheimer's Disease by Regulating DNA Methylation in Rodents. / 2019 / PubMed / Full text
Human iPSC-derived MSCs (iMSCs) from aged individuals acquire a rejuvenation signature. / 18.03.2019 / PubMed / Full text
Effects of Parental Aging During Embryo Development and Adult Life: The Case of Nothobranchius furzeri. / 04.2018 / PubMed / Full text
Induced Pluripotent Stem Cell-Derived Dopaminergic Neurons from Adult Common Marmoset Fibroblasts. / 01.09.2017 / PubMed / Full text
Forkhead box A2 regulates biliary heterogeneity and senescence during cholestatic liver injury in mice‡. / 02.2017 / PubMed / Full text
Age-dependent expression of DNMT1 and DNMT3B in PBMCs from a large European population enrolled in the MARK-AGE study. / 08.2016 / PubMed / Full text
Insight into the molecular pathophysiology of myelodysplastic syndromes: targets for novel therapy. / 10.2016 / PubMed / Full text

ESR1

Menopause and adipose tissue: miR-19a-3p is sensitive to hormonal replacement. / 05.01.2018 / PubMed / Full text
Inter-Regional Variations in Gene Expression and Age-Related Cortical Thinning in the Adolescent Brain. / 01.04.2018 / PubMed / Full text
Age- and menopause-related differences in subcutaneous adipose tissue estrogen receptor mRNA expression. / 05.2017 / PubMed / Full text
Association of PvuII and XbaI polymorphisms on estrogen receptor alpha (ESR1) gene to changes into serum lipid profile of post-menopausal women: Effects of aging, body mass index and breast cancer incidence. / 2017 / PubMed / Full text
Differential roles of estrogen receptors, ESR1 and ESR2, in adult rat spermatogenesis. / 15.06.2016 / PubMed / Full text
Brain volumes in late life: gender, hormone treatment, and estrogen receptor variants. / 03.2014 / PubMed / Full text
Prospective analysis of the association between estrogen receptor gene variants and the risk of cognitive decline in elderly women. / 12.2013 / PubMed / Full text
Estrogen receptor alpha single nucleotide polymorphism as predictor of diabetes type 2 risk in hypogonadal men. / 06.2013 / PubMed / Full text

ESR2

Inter-Regional Variations in Gene Expression and Age-Related Cortical Thinning in the Adolescent Brain. / 01.04.2018 / PubMed / Full text
Age- and menopause-related differences in subcutaneous adipose tissue estrogen receptor mRNA expression. / 05.2017 / PubMed / Full text
Differential roles of estrogen receptors, ESR1 and ESR2, in adult rat spermatogenesis. / 15.06.2016 / PubMed / Full text
Effects of Age and Estradiol on Gene Expression in the Rhesus Macaque Hypothalamus. / 2015 / PubMed / Full text
Estrogen receptor β variants modify risk for Alzheimer's disease in a multiethnic female cohort. / 2014 / PubMed / Full text
Brain volumes in late life: gender, hormone treatment, and estrogen receptor variants. / 03.2014 / PubMed / Full text
Prospective analysis of the association between estrogen receptor gene variants and the risk of cognitive decline in elderly women. / 12.2013 / PubMed / Full text
Estrogen receptor alpha single nucleotide polymorphism as predictor of diabetes type 2 risk in hypogonadal men. / 06.2013 / PubMed / Full text

FAAH

Endocannabinoid genetic variation enhances vulnerability to THC reward in adolescent female mice. / 02.2020 / PubMed / Full text
Pharmacological convergence reveals a lipid pathway that regulates C. elegans lifespan. / 05.2019 / PubMed / Full text
Stimulation of brain glucose uptake by cannabinoid CB2 receptors and its therapeutic potential in Alzheimer's disease. / 11.2016 / PubMed / Full text
Sustained Endocannabinoid Signaling Compromises Decidual Function and Promotes Inflammation-induced Preterm Birth. / 08.04.2016 / PubMed / Full text
Decreased anxiety in juvenile rats following exposure to low levels of chlorpyrifos during development. / 03.2017 / PubMed / Full text
Enhanced microglial activity in FAAH(-/-) animals. / 01.10.2015 / PubMed / Full text
Normal aging in rats and pathological aging in human Alzheimer's disease decrease FAAH activity: modulation by cannabinoid agonists. / 12.2014 / PubMed / Full text
Induction of endocannabinoid levels in juvenile rat brain following developmental chlorpyrifos exposure. / 09.2013 / PubMed / Full text

GBA

Reduced sphingolipid hydrolase activities, substrate accumulation and ganglioside decline in Parkinson's disease. / 08.11.2019 / PubMed / Full text
[i]Malassezia[/i] and Parkinson's Disease. / 2019 / PubMed / Full text
Glycosphingolipid levels and glucocerebrosidase activity are altered in normal aging of the mouse brain. / 07.2018 / PubMed / Full text
GBA mutations in Parkinson disease: earlier death but similar neuropathological features. / 11.2017 / PubMed / Full text
Cognitive and motor functioning in elderly glucocerebrosidase mutation carriers. / 10.2017 / PubMed / Full text
Age and gender-specific reference intervals for lysosomal enzymes in dried blood spot samples: A study in Indian population. / 10.2017 / PubMed / Full text
Minos-insertion mutant of the Drosophila GBA gene homologue showed abnormal phenotypes of climbing ability, sleep and life span with accumulation of hydroxy-glucocerebroside. / 30.05.2017 / PubMed / Full text
Impact of lysosomal storage disorders on biology of mesenchymal stem cells: Evidences from in vitro silencing of glucocerebrosidase (GBA) and alpha-galactosidase A (GLA) enzymes. / 12.2017 / PubMed / Full text

GLA

TLR-adjuvanted nanoparticle vaccines differentially influence the quality and longevity of responses to malaria antigen Pfs25. / 17.05.2018 / PubMed / Full text
Gamma-linolenic acid ameliorated glycation-induced memory impairment in rats. / 12.2017 / PubMed / Full text
Age and gender-specific reference intervals for lysosomal enzymes in dried blood spot samples: A study in Indian population. / 10.2017 / PubMed / Full text
Impact of lysosomal storage disorders on biology of mesenchymal stem cells: Evidences from in vitro silencing of glucocerebrosidase (GBA) and alpha-galactosidase A (GLA) enzymes. / 12.2017 / PubMed / Full text
In vitro cytokine induction by TLR-activating vaccine adjuvants in human blood varies by age and adjuvant. / 07.2016 / PubMed / Full text
The stimulatory effect of the TLR4-mediated adjuvant glucopyranosyl lipid A is well preserved in old age. / 02.2016 / PubMed / Full text
Genome-wide association study of plasma N6 polyunsaturated fatty acids within the cohorts for heart and aging research in genomic epidemiology consortium. / 06.2014 / PubMed / Full text
Protective effect of borage seed oil and gamma linolenic acid on DNA: in vivo and in vitro studies. / 2013 / PubMed / Full text

GPI

Blood factors transfer beneficial effects of exercise on neurogenesis and cognition to the aged brain. / 10.07.2020 / PubMed / Full text
Potential role of exercise-induced glucose-6-phosphate isomerase in skeletal muscle function. / 30.06.2019 / PubMed / Full text
Red Blood Cell Homeostasis and Altered Vesicle Formation in Patients With Paroxysmal Nocturnal Hemoglobinuria. / 2019 / PubMed / Full text
Can the health of a nation be correlated to its state of internal peace? / 01-03.2016 / PubMed / Full text
Developmental role of the cell adhesion molecule Contactin-6 in the cerebral cortex and hippocampus. / 03.07.2016 / PubMed / Full text
Metabolic consequences of long-term rapamycin exposure on common marmoset monkeys (Callithrix jacchus). / 11.2015 / PubMed / Full text
Urokinase receptor and resistance to targeted anticancer agents. / 2015 / PubMed / Full text
The glycolytic enzyme, GPI, is a functionally conserved modifier of dopaminergic neurodegeneration in Parkinson's models. / 01.07.2014 / PubMed / Full text

GSS

Spontaneous generation of prions and transmissible PrP amyloid in a humanised transgenic mouse model of A117V GSS. / 06.2020 / PubMed / Full text
Geriatric brain tumor management part I: Meningioma. / 09.2019 / PubMed / Full text
Link between cardiac function and the antioxidative defense mechanism in aged rats. / 11.06.2019 / PubMed / Full text
Towards improving sterile insect technique: Exposure to orange oil compounds increases sexual signalling and longevity in Ceratitis capitata males of the Vienna 8 GSS. / 2017 / PubMed / Full text
Age-dependent changes of the antioxidant system in rat livers are accompanied by altered MAPK activation and a decline in motor signaling. / 2015 / PubMed / Full text
Comparison of Anastrepha ludens (Diptera: Tephritidae) Bisexual and Genetic Sexing (Tapachula-7) Strains: Effect of Hypoxia, Fly Density, Chilling Period, and Food Type on Fly Quality. / 04.2016 / PubMed / Full text
The Geriatric Scoring System (GSS) for Risk Stratification in Meningioma Patients as a Predictor of Outcome in Patients Treated with Radiosurgery. / 03.2016 / PubMed / Full text
'Start to finish trans-institutional transdisciplinary care': a novel approach improves colorectal surgical results in frail elderly patients. / 01.2016 / PubMed / Full text

GSTM1

The effects of everyday-life exposure to polycyclic aromatic hydrocarbons on biological age indicators. / 03.12.2020 / PubMed / Full text
Carrying the T Allele of the SNP rs574344, an eQTL of GSTM1, Contributes to Longevity in the Han Chinese Population. / 01.2019 / PubMed / Full text
Age-associated changes in GSH S-transferase gene/proteins in livers of rats. / 12.2018 / PubMed / Full text
Aging-dependent DNA hypermethylation and gene expression of GSTM1 involved in T cell differentiation. / 25.07.2017 / PubMed / Full text
[Age features of cytogenetic effects of spring-summer encephalitis among residents of northern western Siberia in connection with polymorphism for genes of glutathione-S-transferase]. / 2016 / PubMed
Lead-Related Genetic Loci, Cumulative Lead Exposure and Incident Coronary Heart Disease: The Normative Aging Study. / 2016 / PubMed / Full text
Effects of APOE rs429358, rs7412 and GSTM1/GSTT1 Polymorphism on Plasma and Erythrocyte Antioxidant Parameters and Cognition in Old Chinese Adults. / 24.09.2015 / PubMed / Full text
[Frequency of gene polymorphic variants (phase II) of biotransformation of GSTT1 and GSTM1 xenobiotics among long-livers (Precarpathian region)]. / 2013 / PubMed

HFE

Polyphenol Characterization and Skin-Preserving Properties of Hydroalcoholic Flower Extract from [i]Himantoglossum robertianum[/i] (Orchidaceae). / 14.11.2019 / PubMed / Full text
Hydroalcoholic extract of Spartium junceum L. flowers inhibits growth and melanogenesis in B16-F10 cells by inducing senescence. / 15.07.2018 / PubMed / Full text
Iron-processing genotypes, nutrient intakes, and cadmium levels in the Normative Aging Study: Evidence of sensitive subpopulations in cadmium risk assessment. / 10.2018 / PubMed / Full text
Lead-Related Genetic Loci, Cumulative Lead Exposure and Incident Coronary Heart Disease: The Normative Aging Study. / 2016 / PubMed / Full text
Haplotype analysis of the HFE gene among populations of Northern Eurasia, in patients with metabolic disorders or stomach cancer, and in long-lived people. / 17.06.2016 / PubMed / Full text
No Association between Variation in Longevity Candidate Genes and Aging-related Phenotypes in Oldest-old Danes. / 06.2016 / PubMed / Full text
Cumulative lead exposure is associated with reduced olfactory recognition performance in elderly men: The Normative Aging Study. / 07.2015 / PubMed / Full text
[[[CCR5]], CCR2, apoe, p53, ITGB3 and HFE gene polymorphism in Western Siberia long-livers]. / 2012 / PubMed

HMOX1

Protective role of microglial HO-1 blockade in aging: Implication of iron metabolism. / 06.11.2020 / PubMed / Full text
Well-aging: A new strategy for skin homeostasis under multi-stressed conditions. / 02.2020 / PubMed / Full text
Age-related distribution and potential role of SNCB in topographically different retinal areas of the common marmoset Callithrix jacchus, including the macula. / 08.2019 / PubMed / Full text
Lead-Related Genetic Loci, Cumulative Lead Exposure and Incident Coronary Heart Disease: The Normative Aging Study. / 2016 / PubMed / Full text
Exercise-induced Nrf2-signaling is impaired in aging. / 07.2016 / PubMed / Full text
Behaviour and cognitive changes correlated with hippocampal neuroinflammaging and neuronal markers in female SAMP8, a model of accelerated senescence. / 07.2016 / PubMed / Full text
Neurotherapeutic effects of novel HO-1 inhibitors in vitro and in a transgenic mouse model of Alzheimer's disease. / 12.2014 / PubMed / Full text
Astroglial heme oxygenase-1 and the origin of corpora amylacea in aging and degenerating neural tissues. / 04.2014 / PubMed / Full text

LBR

Lamin B receptor: role on chromatin structure, cellular senescence and possibly aging. / 31.07.2020 / PubMed / Full text
The impact of age beyond ploidy: outcome data from 8175 euploid single embryo transfers. / 03.2020 / PubMed / Full text
The role of lamin B receptor in the regulation of senescence-associated secretory phenotype (SASP). / 01.05.2020 / PubMed / Full text
Lamin B receptor plays a key role in cellular senescence induced by inhibition of the proteasome. / 11.12.2019 / PubMed / Full text
Lamin B receptor (LBR) is involved in the induction of cellular senescence in human cells. / 03.2019 / PubMed / Full text
Consequences of Lamin B1 and Lamin B Receptor Downregulation in Senescence. / 06.02.2018 / PubMed / Full text
Overexpression of Lamin B Receptor Results in Impaired Skin Differentiation. / 2015 / PubMed / Full text
Embryonic expression of the common progeroid lamin A splice mutation arrests postnatal skin development. / 04.2014 / PubMed / Full text

LPL

Survival analyses in Holstein cows considering direct disease diagnoses and specific SNP marker effects. / 09.2020 / PubMed / Full text
Influence of common health disorders on the length of productive life and stayability in German Holstein cows. / 01.2020 / PubMed / Full text
GH prevents adipogenic differentiation of mesenchymal stromal stem cells derived from human trabecular bone via canonical Wnt signaling. / 07.2018 / PubMed / Full text
Genetic correlation and genome-wide association study (GWAS) of the length of productive life, days open, and 305-days milk yield in crossbred Holstein dairy cattle. / 29.06.2017 / PubMed / Full text
Association of Metabolic Syndrome with Serum Adipokines in Community-Living Elderly Japanese Women: Independent Association with Plasminogen Activator-Inhibitor-1. / 11.2015 / PubMed / Full text
Moderate Exercise Mitigates the Detrimental Effects of Aging on Tendon Stem Cells. / 2015 / PubMed / Full text
Association of adiponectin with serum preheparin lipoprotein lipase mass in women independent of fat mass and distribution, insulin resistance, and inflammation. / 10.2014 / PubMed / Full text
[Clinical and genetic characteristics of long-livers in Moscow region]. / 2013 / PubMed

LTA

Lipoteichoic acid from the cell wall of a heat killed Lactobacillus paracasei D3-5 ameliorates aging-related leaky gut, inflammation and improves physical and cognitive functions: from C. elegans to mice. / 02.2020 / PubMed / Full text
The change of pain classes over time: a latent transition analysis. / 02.2020 / PubMed / Full text
Leisure time activities as mediating variables in functional disability progression: An application of parallel latent growth curve modeling. / 2018 / PubMed / Full text
The Neighborhood Built Environment and Cognitive Function of Older Persons: Results from the Singapore Longitudinal Ageing Study. / 2018 / PubMed / Full text
Changes in depression among older adults in China: A latent transition analysis. / 02.2017 / PubMed / Full text
Joint effect of gene-physical activity and the interactions among CRP, TNF-α, and LTA polymorphisms on serum CRP, TNF-α levels, and handgrip strength in community-dwelling elders in Taiwan - TCHS-E. / 04.2016 / PubMed / Full text
In vitro anti-platelet potency of ticagrelor in blood samples from infants and children. / 09.2015 / PubMed / Full text
Physical Activity, Mediterranean Diet and Biomarkers-Assessed Risk of Alzheimer's: A Multi-Modality Brain Imaging Study. / 10.2014 / PubMed / Full text

MAG

Exploration of life satisfaction of Korean people with sensory impairments across the lifespan. / 10.2020 / PubMed / Full text
Omega-3 Monoacylglyceride Effects on Longevity, Mitochondrial Metabolism and Oxidative Stress: Insights from [i]Drosophila melanogaster[/i]. / 16.11.2018 / PubMed / Full text
Glial Sulfatides and Neuronal Complex Gangliosides Are Functionally Interdependent in Maintaining Myelinating Axon Integrity. / 02.01.2019 / PubMed / Full text
Gray Matter Volume and Cognitive Performance During Normal Aging. A Voxel-Based Morphometry Study. / 2018 / PubMed / Full text
Oxidative Stress Function in Women over 40 Years of Age, Considering Their Lifestyle. / 2017 / PubMed / Full text
Age-related changes in retinoic, docosahexaenoic and arachidonic acid modulation in nuclear lipid metabolism. / 15.08.2016 / PubMed / Full text
Transcriptional and biochemical responses of monoacylglycerol acyltransferase-mediated oil synthesis and associated senescence-like responses in Nicotiana benthamiana. / 2014 / PubMed / Full text
Electromechanical delay of the knee extensor muscles: comparison among young, middle-age and older individuals. / 07.2015 / PubMed / Full text

MITF

Thymocid , a Standardized Black Cumin ([i]Nigella sativa[/i]) Seed Extract, Modulates Collagen Cross-Linking, Collagenase and Elastase Activities, and Melanogenesis in Murine B16F10 Melanoma Cells. / 19.07.2020 / PubMed / Full text
HuRdling Senescence: HuR Breaks BRAF-Induced Senescence in Melanocytes and Supports Melanoma Growth. / 21.05.2020 / PubMed / Full text
Extracellular acidosis triggers a senescence-like phenotype in human melanoma cells. / 01.2020 / PubMed / Full text
H O promotes the aging process of melanogenesis through modulation of MITF and Nrf2. / 04.2019 / PubMed / Full text
Deregulated MITF sumoylation: A route to melanoma. / 2017 / PubMed / Full text
Phosphorylation of MITF by AKT affects its downstream targets and causes TP53-dependent cell senescence. / 11.2016 / PubMed / Full text
Parthenolide induces MITF-M downregulation and senescence in patient-derived MITF-M(high) melanoma cell populations. / 23.02.2016 / PubMed / Full text
Regulatory and functional connection of microphthalmia-associated transcription factor and anti-metastatic pigment epithelium derived factor in melanoma. / 06.2014 / PubMed / Full text

NNT

Yoga, Health-Related Quality of Life and Mental Well-Being: A Re-analysis of a Meta-analysis Using the Quality Effects Model. / 16.09.2020 / PubMed / Full text
Statins After Myocardial Infarction in the Oldest: A Cohort Study in the Clinical Practice Research Datalink Database. / 02.2020 / PubMed / Full text
Years of Life Lost for Older Patients After Colorectal Cancer Diagnosis. / 08.2019 / PubMed / Full text
Nicotinamide nucleotide transhydrogenase is required for brain mitochondrial redox balance under hampered energy substrate metabolism and high-fat diet. / 12.2018 / PubMed / Full text
Upregulation of mitochondrial NAD levels impairs the clonogenicity of SSEA1 glioblastoma tumor-initiating cells. / 09.06.2017 / PubMed / Full text
The Health Gain Obtainable from Pancreatic Resection for Adenocarcinoma in the Elderly. / 04.2017 / PubMed / Full text
Restoration of Mitochondrial NAD Levels Delays Stem Cell Senescence and Facilitates Reprogramming of Aged Somatic Cells. / 12.2016 / PubMed / Full text
Relative importance of redox buffers GSH and NAD(P)H in age-related neurodegeneration and Alzheimer disease-like mouse neurons. / 08.2014 / PubMed / Full text

NOS2

Metformin alters peripheral blood mononuclear cells (PBMC) senescence biomarkers gene expression in type 2 diabetic patients. / 01.2021 / PubMed / Full text
Genetic background, epigenetic factors and dietary interventions which influence human longevity. / 10.2019 / PubMed / Full text
Secreted α-Klotho maintains cartilage tissue homeostasis by repressing [i]NOS2[/i] and [i]ZIP8-MMP13[/i] catabolic axis. / 19.06.2018 / PubMed / Full text
Analysis of molecular networks and targets mining of Chinese herbal medicines on anti-aging. / 28.12.2016 / PubMed / Full text
All-trans retinoic acid (ATRA) prevents lipopolysaccharide-induced neuroinflammation, amyloidogenesis and memory impairment in aged rats. / 15.11.2016 / PubMed / Full text
TNFα antagonization alters NOS2 dependent nasopharyngeal carcinoma tumor growth. / 07.2015 / PubMed / Full text
Bone marrow-derived macrophages from aged rats are more responsive to inflammatory stimuli. / 09.04.2015 / PubMed / Full text
Common polymorphisms in nitric oxide synthase (NOS) genes influence quality of aging and longevity in humans. / 04.2013 / PubMed / Full text

NPS

Cortical β-amyloid burden, neuropsychiatric symptoms, and cognitive status: the Mayo Clinic Study of Aging. / 28.03.2019 / PubMed / Full text
Mild Behavioral Impairment as a Marker of Cognitive Decline in Cognitively Normal Older Adults. / 08.2019 / PubMed / Full text
The course of neuropsychiatric symptoms in patients with dementia in primary care. / 31.07.2019 / PubMed / Full text
Serum calcium levels and neuropsychological performance in depression and matched healthy controls: Reversal of correlation a marker of the aging cognitive clock? / 05.2018 / PubMed / Full text
Persistent use of psychotropic drugs in nursing home residents in Norway. / 13.02.2017 / PubMed / Full text
FDG-PET and Neuropsychiatric Symptoms among Cognitively Normal Elderly Persons: The Mayo Clinic Study of Aging. / 14.07.2016 / PubMed / Full text
Cardiorenal fibrosis and dysfunction in aging: Imbalance in mediators and regulators of collagen. / 02.2016 / PubMed / Full text
Personalized technology to support older adults with and without cognitive impairment living at home. / 02.2015 / PubMed / Full text

PDE4C

Age prediction in living: Forensic epigenetic age estimation based on blood samples. / 11.2020 / PubMed / Full text
Age Estimation Based on DNA Methylation Using Blood Samples From Deceased Individuals. / 03.2020 / PubMed / Full text
Effect of adding B-vitamins to vitamin D and calcium supplementation on CpG methylation of epigenetic aging markers. / 04.2018 / PubMed / Full text
Development of a methylation marker set for forensic age estimation using analysis of public methylation data and the Agena Bioscience EpiTYPER system. / 09.2016 / PubMed / Full text
Plasma Amyloid Beta 1-42 and DNA Methylation Pattern Predict Accelerated Aging in Young Subjects with Down Syndrome. / 12.2016 / PubMed / Full text
Age-associated changes in DNA methylation across multiple tissues in an inbred mouse model. / 03.2016 / PubMed / Full text
Improved age determination of blood and teeth samples using a selected set of DNA methylation markers. / 2015 / PubMed / Full text
Aging of blood can be tracked by DNA methylation changes at just three CpG sites. / 03.02.2014 / PubMed / Full text

PDK1

Inhibition of 3-phosphoinositide-dependent protein kinase 1 (PDK1) can revert cellular senescence in human dermal fibroblasts. / 08.12.2020 / PubMed / Full text
The Impact of the PI3K/Akt Signaling Pathway in Anxiety and Working Memory in Young and Middle-Aged PDK1 K465E Knock-In Mice. / 2020 / PubMed / Full text
Peripheral Circulating Exosomal miRNAs Potentially Contribute to the Regulation of Molecular Signaling Networks in Aging. / 11.03.2020 / PubMed / Full text
Vps15 is critical to mediate autophagy in AngII treated HUVECs probably by PDK1/PKC signaling pathway. / 15.09.2019 / PubMed / Full text
Acupuncture Administration Improves Cognitive Functions and Alleviates Inflammation and Nuclear Damage by Regulating Phosphatidylinositol 3 Kinase (PI3K)/Phosphoinositol-Dependent Kinase 1 (PDK1)/Novel Protein Kinase C (nPKC)/Rac 1 Signaling Pathway in Senescence-Accelerated Prone 8 (SAM-P8) Mice. / 01.06.2019 / PubMed / Full text
Identification of ATF-7 and the insulin signaling pathway in the regulation of metallothionein in C. elegans suggests roles in aging and reactive oxygen species. / 2017 / PubMed / Full text
Selective deletion of Pten in theca-interstitial cells leads to androgen excess and ovarian dysfunction in mice. / 15.03.2017 / PubMed / Full text
Serine- and threonine/valine-dependent activation of PDK and Tor orthologs converge on Sch9 to promote aging. / 02.2014 / PubMed / Full text

PPID

Relationships of inflamm-aging with circulating nutrient levels, body composition, age, and pituitary pars intermedia dysfunction in a senior horse population. / 03.2020 / PubMed / Full text
Epidemiology of pituitary pars intermedia dysfunction: A systematic literature review of clinical presentation, disease prevalence and risk factors. / 05.2018 / PubMed / Full text
Effect of Age, Season, Body Condition, and Endocrine Status on Serum Free Cortisol Fraction and Insulin Concentration in Horses. / 03-04.2016 / PubMed / Full text
Age-related Qualitative Histological and Quantitative Stereological Changes in the Equine Pituitary. / 02-04.2016 / PubMed / Full text
What's New in Old Horses? Postmortem Diagnoses in Mature and Aged Equids. / 03.2016 / PubMed / Full text
Pituitary pars intermedia dysfunction does not necessarily impair insulin sensitivity in old horses. / 01.2015 / PubMed / Full text
Evaluation of the effects of age and pituitary pars intermedia dysfunction on corneal sensitivity in horses. / 07.2013 / PubMed / Full text
Comparison of hair follicle histology between horses with pituitary pars intermedia dysfunction and excessive hair growth and normal aged horses. / 02.2013 / PubMed / Full text

PSEN1

Genome-wide alteration of 5-hydroxymenthylcytosine in a mouse model of Alzheimer's disease. / 20.05.2016 / PubMed / Full text
White Matter Abnormalities Track Disease Progression in PSEN1 Autosomal Dominant Alzheimer's Disease. / 2016 / PubMed / Full text
Characterization of Amyloid-β Deposits in Bovine Brains. / 2016 / PubMed / Full text
Functions of miR-9 and miR-9* during Aging in SAMP8 Mice and Their Possible Mechanisms. / 06.2015 / PubMed / Full text
DBA/2J genetic background exacerbates spontaneous lethal seizures but lessens amyloid deposition in a mouse model of Alzheimer's disease. / 2015 / PubMed / Full text
Associations between biomarkers and age in the presenilin 1 E280A autosomal dominant Alzheimer disease kindred: a cross-sectional study. / 03.2015 / PubMed / Full text
Age-dependent, non-cell-autonomous deposition of amyloid from synthesis of β-amyloid by cells other than excitatory neurons. / 05.03.2014 / PubMed / Full text
Endogenous expression of FAD-linked PS1 impairs proliferation, neuronal differentiation and survival of adult hippocampal progenitors. / 20.10.2013 / PubMed / Full text

RAD50

ATM Deficiency Accelerates DNA Damage, Telomere Erosion, and Premature T Cell Aging in HIV-Infected Individuals on Antiretroviral Therapy. / 2019 / PubMed / Full text
Transactivation domain of p53 regulates DNA repair and integrity in human iPS cells. / 01.09.2018 / PubMed / Full text
Phosphorylation of WHIRLY1 by CIPK14 Shifts Its Localization and Dual Functions in Arabidopsis. / 01.05.2017 / PubMed / Full text
HIF-1α and rapamycin act as gerosuppressant in multiple myeloma cells upon genotoxic stress. / 17.08.2016 / PubMed / Full text
Immunochip analysis identifies association of the RAD50/IL13 region with human longevity. / 06.2016 / PubMed / Full text
Causal mechanisms and balancing selection inferred from genetic associations with polycystic ovary syndrome. / 29.09.2015 / PubMed / Full text
Targeting of DNA Damage Signaling Pathway Induced Senescence and Reduced Migration of Cancer cells. / 06.2015 / PubMed / Full text
Copy neutral loss of heterozygosity is more frequent in older ovarian cancer patients. / 09.2013 / PubMed / Full text

SCT

Short-Term Training and Detraining Effects of Supervised vs. Unsupervised Resistance Exercise in Aging Adults. / 10.2019 / PubMed / Full text
High-intensity interval training improves acute plasma volume responses to exercise that is age dependent. / 02.2018 / PubMed / Full text
Communication technology adoption among older adult veterans: the interplay of social and cognitive factors. / 12.2018 / PubMed / Full text
Repeatability of Choroidal Thickness Measurements on Enhanced Depth Imaging Optical Coherence Tomography Using Different Posterior Boundaries. / 09.2016 / PubMed / Full text
HIV cure strategies: how good must they be to improve on current antiretroviral therapy? / 2014 / PubMed / Full text
Quadriceps intramuscular fat fraction rather than muscle size is associated with knee osteoarthritis. / 02.2014 / PubMed / Full text
Robust measurement of telomere length in single cells. / 21.05.2013 / PubMed / Full text
The effectiveness of stem cell therapies on health-related quality of life and life expectancy in comparison with conventional supportive medical treatment in patients suffering from end-stage liver disease. / 25.02.2013 / PubMed / Full text

SNCA

Behavioural and dopaminergic changes in double mutated human A30P*A53T alpha-synuclein transgenic mouse model of Parkinson´s disease. / 22.11.2019 / PubMed / Full text
Reducing INS-IGF1 signaling protects against non-cell autonomous vesicle rupture caused by SNCA spreading. / 05.2020 / PubMed / Full text
SerThr-PhosphoProteome of Brain from Aged PINK1-KO A53T-SNCA Mice Reveals pT1928-MAP1B and pS3781-ANK2 Deficits, as Hub between Autophagy and Synapse Changes. / 04.07.2019 / PubMed / Full text
Age-dependent accumulation of oligomeric SNCA/α-synuclein from impaired degradation in mutant LRRK2 knockin mouse model of Parkinson disease: role for therapeutic activation of chaperone-mediated autophagy (CMA). / 02.2020 / PubMed / Full text
Caloric restriction rescues yeast cells from alpha-synuclein toxicity through autophagic control of proteostasis. / 07.12.2018 / PubMed / Full text
Epigallocatechin-3-gallate increases autophagy signaling in resting and unloaded plantaris muscles but selectively suppresses autophagy protein abundance in reloaded muscles of aged rats. / 06.2017 / PubMed / Full text
DNA methylation levels of α-synuclein intron 1 in the aging brain. / 12.2015 / PubMed / Full text
Deficits in dopaminergic transmission precede neuron loss and dysfunction in a new Parkinson model. / 15.10.2013 / PubMed / Full text

SOD3

Whole Genome Analysis of the Red-Crowned Crane Provides Insight into Avian Longevity. / 31.01.2020 / PubMed / Full text
Prenatal hypoxia affected endothelium-dependent vasodilation in mesenteric arteries of aged offspring via increased oxidative stress. / 06.2019 / PubMed / Full text
Superoxide dismutase activity is significantly lower in end-stage osteoarthritic cartilage than non-osteoarthritic cartilage. / 2018 / PubMed / Full text
In silico analysis and molecular dynamics simulation of human superoxide dismutase 3 (SOD3) genetic variants. / 03.2019 / PubMed / Full text
Proteomic profiling of follicle fluids after superstimulation in one-month-old lambs. / 02.2018 / PubMed / Full text
Molecular evolutionary patterns of NAD /Sirtuin aging signaling pathway across taxa. / 2017 / PubMed / Full text
Extracellular superoxide dismutase deficiency impairs wound healing in advanced age by reducing neovascularization and fibroblast function. / 03.2016 / PubMed / Full text
Superoxide dismutase gene polymorphisms in patients with age-related cataract. / 09.2013 / PubMed / Full text

TIGIT

Association of Epigenetic Age and p16INK4a With Markers of T-Cell Composition in a Healthy Cohort. / 13.11.2020 / PubMed / Full text
Implications of Immune Checkpoint Expression During Aging in HIV-Infected People on Antiretroviral Therapy. / 11-12.2019 / PubMed / Full text
Impaired Cytolytic Activity and Loss of Clonal Neoantigens in Elderly Patients With Lung Adenocarcinoma. / 05.2019 / PubMed / Full text
Multivariate Computational Analysis of Gamma Delta T Cell Inhibitory Receptor Signatures Reveals the Divergence of Healthy and ART-Suppressed HIV Aging. / 2018 / PubMed / Full text
Characterization of Blimp-1 function in effector regulatory T cells. / 07.2018 / PubMed / Full text
T-cell Immunoglobulin and ITIM Domain Contributes to CD8 T-cell Immunosenescence. / 04.2018 / PubMed / Full text
Long-Lived CD4 IFN-γ T Cells rather than Short-Lived CD4 IFN-γ IL-10 T Cells Initiate Rapid IL-10 Production To Suppress Anamnestic T Cell Responses during Secondary Malaria Infection. / 15.10.2016 / PubMed / Full text
Combinatorial approach to cancer immunotherapy: strength in numbers. / 08.2016 / PubMed / Full text

TIMP1

Senescence Reprogramming by TIMP1 Deficiency Promotes Prostate Cancer Metastasis. / 26.10.2020 / PubMed / Full text
Design, cyclization, and optimization of MMP13-TIMP1 interaction-derived self-inhibitory peptides against chondrocyte senescence in osteoarthritis. / 01.2019 / PubMed / Full text
Retinoic acid promotes in vitro follicle activation in the cat ovary by regulating expression of matrix metalloproteinase 9. / 2018 / PubMed / Full text
Timing and duration of nursing from birth affect neonatal porcine uterine matrix metalloproteinase 9 and tissue inhibitor of metalloproteinase 1. / 04.2017 / PubMed / Full text
Effect of TIMP1 transfection on PTEN expression in human kidney proximal tubular cells. / 21.12.2015 / PubMed / Full text
Biological Effects Induced by Specific Advanced Glycation End Products in the Reconstructed Skin Model of Aging. / 2015 / PubMed / Full text
Fat and Sucrose Intake Induces Obesity-Related Bone Metabolism Disturbances: Kinetic and Reversibility Studies in Growing and Adult Rats. / 01.2016 / PubMed / Full text
Exercise training initiated in late middle age attenuates cardiac fibrosis and advanced glycation end-product accumulation in senescent rats. / 02.2014 / PubMed / Full text

TRPM2

Paraquat as an Environmental Risk Factor in Parkinson's Disease Accelerates Age-Related Degeneration Via Rapid Influx of Extracellular Zn into Nigral Dopaminergic Neurons. / 11.2019 / PubMed / Full text
Pathophysiological Role of TRPM2 in Age-Related Cognitive Impairment in Mice. / 01.06.2019 / PubMed / Full text
The TRPM2 channel nexus from oxidative damage to Alzheimer's pathologies: An emerging novel intervention target for age-related dementia. / 11.2018 / PubMed / Full text
TRPM2 in the Brain: Role in Health and Disease. / 22.07.2018 / PubMed / Full text
mRNA expression of transient receptor potential melastatin (TRPM) channels 2 and 7 in perinatal brain development. / 10.2018 / PubMed / Full text
Prolactin protects retinal pigment epithelium by inhibiting sirtuin 2-dependent cell death. / 05.2016 / PubMed / Full text
Extended therapeutic window of a novel peptide inhibitor of TRPM2 channels following focal cerebral ischemia. / 09.2016 / PubMed / Full text
The Protective Role of Selenium on Scopolamine-Induced Memory Impairment, Oxidative Stress, and Apoptosis in Aged Rats: The Involvement of TRPM2 and TRPV1 Channels. / 05.2017 / PubMed / Full text

TRPV4

TRPV4 receptor as a functional sensory molecule in bladder urothelium: Stretch-independent, tissue-specific actions and pathological implications. / 01.2020 / PubMed / Full text
Exercise restores impaired endothelium-derived hyperpolarizing factor-mediated vasodilation in aged rat aortic arteries via the TRPV4-K 2.3 signaling complex. / 2019 / PubMed / Full text
Autonomic dysregulation at multiple sites is implicated in age-associated underactive bladder in female mice. / 06.2019 / PubMed / Full text
Reduced bladder responses to capsaicin and GSK-1016790A in retired-breeder female rats with diminished volume sensitivity. / 01.11.2018 / PubMed / Full text
Cartilage-Specific Knockout of the Mechanosensory Ion Channel TRPV4 Decreases Age-Related Osteoarthritis. / 08.07.2016 / PubMed / Full text
Increasing TRPV4 expression restores flow-induced dilation impaired in mesenteric arteries with aging. / 07.03.2016 / PubMed / Full text
Berberine via suppression of transient receptor potential vanilloid 4 channel improves vascular stiffness in mice. / 11.2015 / PubMed / Full text
Age-related changes in the distribution of transient receptor potential vanilloid 4 channel (TRPV4) in the central nervous system of rats. / 10.2014 / PubMed / Full text

TSC2

AMPK/TSC2/mTOR pathway regulates replicative senescence of human vascular smooth muscle cells. / 12.2018 / PubMed / Full text
Autophagy mediators (FOXO1, SESN3 and TSC2) in Lewy body disease and aging. / 25.09.2018 / PubMed / Full text
FTO is involved in Alzheimer's disease by targeting TSC1-mTOR-Tau signaling. / 25.03.2018 / PubMed / Full text
Postnatal reduction of tuberous sclerosis complex 1 expression in astrocytes and neurons causes seizures in an age-dependent manner. / 12.2017 / PubMed / Full text
Complex inhibition of autophagy by mitochondrial aldehyde dehydrogenase shortens lifespan and exacerbates cardiac aging. / 08.2017 / PubMed / Full text
Autophagy inhibition switches low-dose camptothecin-induced premature senescence to apoptosis in human colorectal cancer cells. / 01.08.2014 / PubMed / Full text
mTOR inactivation by ROS-JNK-p53 pathway plays an essential role in psedolaric acid B induced autophagy-dependent senescence in murine fibrosarcoma L929 cells. / 05.09.2013 / PubMed / Full text
Timing of mTOR activation affects tuberous sclerosis complex neuropathology in mouse models. / 09.2013 / PubMed / Full text

UCHL1

Abolishing UCHL1's hydrolase activity exacerbates TBI-induced axonal injury and neuronal death in mice. / 04.11.2020 / PubMed / Full text
FAM96B inhibits the senescence of dental pulp stem cells. / 05.2020 / PubMed / Full text
Role of the Ubiquitin C-Terminal Hydrolase L1-Modulated Ubiquitin Proteasome System in Auditory Cortex Senescence. / 2017 / PubMed / Full text
Life and death in the trash heap: The ubiquitin proteasome pathway and UCHL1 in brain aging, neurodegenerative disease and cerebral Ischemia. / 03.2017 / PubMed / Full text
Amelioration of neuronal cell death in a spontaneous obese rat model by dietary restriction through modulation of ubiquitin proteasome system. / 07.2016 / PubMed / Full text
Effect of age on expression of spermatogonial markers in bovine testis and isolated cells. / 07.2016 / PubMed / Full text
It Is All about (U)biquitin: Role of Altered Ubiquitin-Proteasome System and UCHL1 in Alzheimer Disease. / 2016 / PubMed / Full text
Loss of UCHL1 promotes age-related degenerative changes in the enteric nervous system. / 2014 / PubMed / Full text

VDAC1

Low abundance of NDUFV2 and NDUFS4 subunits of the hydrophilic complex I domain and VDAC1 predicts mammalian longevity. / 07.2020 / PubMed / Full text
17β-estradiol inhibits H O -induced senescence in HUVEC cells through upregulating SIRT3 expression and promoting autophagy. / 10.2020 / PubMed / Full text
Changes in the expression of oxidative phosphorylation complexes in the aging intestinal mucosa. / 01.07.2020 / PubMed / Full text
Age-related sex differences in the expression of important disease-linked mitochondrial proteins in mice. / 05.12.2019 / PubMed / Full text
Cytosolic and mitochondrial Ca concentrations in primary hepatocytes change with ageing and in consequence of an mtDNA mutation. / 09.2019 / PubMed / Full text
The Immp2l mutation causes age-dependent degeneration of cerebellar granule neurons prevented by antioxidant treatment. / 02.2016 / PubMed / Full text
The effect of aging on mitochondrial and cytosolic hepatic intrinsic death pathway and apoptosis associated proteins in Fischer 344 rats. / 07.2015 / PubMed / Full text
Curcumin prevents mitochondrial dysfunction in the brain of the senescence-accelerated mouse-prone 8. / 04.2013 / PubMed / Full text

XRCC1

Impairment of Pol β-related DNA Base-excision Repair Leads to Ovarian Aging in Mice. / 20.11.2020 / PubMed / Full text
Base excision repair but not DNA double-strand break repair is impaired in aged human adipose-derived stem cells. / 02.2020 / PubMed / Full text
[Protective effect of Wuzi Yanzong recipe on testicular DNA oxidative damage in natural ageing rats]. / 07.2018 / PubMed / Full text
The replicative senescent mesenchymal stem / stromal cells defect in DNA damage response and anti-oxidative capacity. / 2018 / PubMed / Full text
XRCC1 and XPD genetic polymorphisms and susceptibility to age-related cataract: a meta-analysis. / 2015 / PubMed / Full text
Polymorphisms of DNA repair genes XPD (Lys751Gln) and XRCC1 (Arg399Gln), and the risk of age-related cataract: a meta-analysis. / 07.2015 / PubMed / Full text
Association between DNA repair genes (XPD and XRCC1) polymorphisms and susceptibility to age-related cataract (ARC): a meta-analysis. / 08.2014 / PubMed / Full text
Polymorphisms in ERCC1 C8092A predict progression-free survival in metastatic/recurrent nasopharyngeal carcinoma treated with cisplatin-based chemotherapy. / 08.2013 / PubMed / Full text

AGA

Extract of Plumbago zeylanica enhances the growth of hair follicle dermal papilla cells with down-regulation of 5α-reductase type II. / 11.2020 / PubMed / Full text
Relationship between androgenic alopecia and white matter hyperintensities in apparently healthy subjects. / 04.2020 / PubMed / Full text
ALKB-8, a 2-Oxoglutarate-Dependent Dioxygenase and S-Adenosine Methionine-Dependent Methyltransferase Modulates Metabolic Events Linked to Lysosome-Related Organelles and Aging in C. elegans. / 2018 / PubMed
The Impact of Being Born Preterm or Small for Gestational Age on Early Vascular Aging in Adolescents. / 10.2018 / PubMed / Full text
Adult height of preterm infants: a longitudinal cohort study. / 06.2017 / PubMed / Full text
The telomere attrition rate is not accelerated in women born small for gestational age: A birth cohort study. / 05.02.2017 / PubMed / Full text
Does prostaglandin D2 hold the cure to male pattern baldness? / 04.2014 / PubMed / Full text

ALB

Effects of Age on Inflammatory Profiles and Nutrition/Energy Metabolism in Domestic Cats. / 2020 / PubMed / Full text
Expression of Transferrin and Albumin in the Sperm-Storage Tubules of Japanese Quail and their Possible Involvement in Long-Term Sperm Storage. / 25.01.2020 / PubMed / Full text
Blood Chemistry Reference Values for Free-Ranging Asiatic Black Bears ( Ursus thibetanus) by Season, Age, and Sex. / 07.2018 / PubMed / Full text
Higher serum albumin was related with diabetes incidence and the impact of BMI changes: Based on cohort study of 18,384 Chinese male elderly. / 12.2017 / PubMed / Full text
Estimating the survival advantage based on telomere length and serum biomarkers of aging. / 01.08.2017 / PubMed / Full text
HEMATOLOGY AND PLASMA CHEMISTRY OF THE PLOUGHSHARE TORTOISE (ASTROCHELYS YNIPHORA) IN A CAPTIVE BREEDING PROGRAM. / 03.2017 / PubMed / Full text
Too old to have children? Lessons from natural fertility populations. / 06.2014 / PubMed / Full text

AMPH

Effects of amphetamine exposure during adolescence on behavior and prelimbic cortex neuron activity in adulthood. / 01.09.2018 / PubMed / Full text
The effects of amphetamine exposure on juvenile rats on the neuronal morphology of the limbic system at prepubertal, pubertal and postpubertal ages. / 11.2016 / PubMed / Full text
Amphetamine modulates brain signal variability and working memory in younger and older adults. / 16.06.2015 / PubMed / Full text
Adolescent exposure to cocaine, amphetamine, and methylphenidate cross-sensitizes adults to methamphetamine with drug- and sex-specific effects. / 15.03.2015 / PubMed / Full text
Age of exposure-dependent effects of amphetamine on behavioral flexibility. / 01.09.2013 / PubMed / Full text
Concurrent choice for social interaction and amphetamine using conditioned place preference in rats: effects of age and housing condition. / 01.05.2013 / PubMed / Full text
Age-dependent effects of repeated amphetamine exposure on working memory in rats. / 01.04.2013 / PubMed / Full text

ATF3

ATF3 represses PINK1 gene transcription in lung epithelial cells to control mitochondrial homeostasis. / 04.2018 / PubMed / Full text
p38 MAPK inhibits nonsense-mediated RNA decay in response to persistent DNA damage in noncycling cells. / 15.09.2017 / PubMed / Full text
Aging Triggers Cytoplasmic Depletion and Nuclear Translocation of the E3 Ligase Mahogunin: A Function for Ubiquitin in Neuronal Survival. / 04.05.2017 / PubMed / Full text
Rutin protects against aging-related metabolic dysfunction. / 02.2016 / PubMed / Full text
Neuroimmune and Neuropathic Responses of Spinal Cord and Dorsal Root Ganglia in Middle Age. / 2015 / PubMed / Full text
Activation of autophagic pathways is related to growth inhibition and senescence in cutaneous squamous cell carcinoma. / 10.2014 / PubMed / Full text
Age-related brain expression and regulation of the chemokine CCL4/MIP-1β in APP/PS1 double-transgenic mice. / 04.2014 / PubMed / Full text

ATG12

Lifelong Football Training: Effects on Autophagy and Healthy Longevity Promotion. / 2019 / PubMed / Full text
SIRT6 histone deacetylase functions as a potential oncogene in human melanoma. / 09.2017 / PubMed / Full text
Epigallocatechin-3-gallate increases autophagy signaling in resting and unloaded plantaris muscles but selectively suppresses autophagy protein abundance in reloaded muscles of aged rats. / 06.2017 / PubMed / Full text
Changes in macroautophagy, chaperone-mediated autophagy, and mitochondrial metabolism in murine skeletal and cardiac muscle during aging. / 26.02.2017 / PubMed / Full text
Autophagic homeostasis is required for the pluripotency of cancer stem cells. / 02.2017 / PubMed / Full text
Macroautophagy is impaired in old murine brain tissue as well as in senescent human fibroblasts. / 12.2016 / PubMed / Full text
Follicle-stimulating hormone promotes age-related endometrial atrophy through cross-talk with transforming growth factor beta signal transduction pathway. / 04.2015 / PubMed / Full text

ATRX

ATRX-DAXX Complex Expression Levels and Telomere Length in Normal Young and Elder Autopsy Human Brains. / 09.2019 / PubMed / Full text
Inactivation of hepatic ATRX in [i]Atrx[/i] Foxg1cre mice prevents reversal of aging-like phenotypes by thyroxine. / 07.06.2018 / PubMed / Full text
Mechanistic understanding of the role of ATRX in senescence provides new insight for combinatorial therapies with CDK4 inhibitors. / 2018 / PubMed / Full text
GBM-associated mutations and altered protein expression are more common in young patients. / 25.10.2016 / PubMed / Full text
Postovulatory aging affects dynamics of mRNA, expression and localization of maternal effect proteins, spindle integrity and pericentromeric proteins in mouse oocytes. / 01.2016 / PubMed / Full text
MDM2 turnover and expression of ATRX determine the choice between quiescence and senescence in response to CDK4 inhibition. / 10.04.2015 / PubMed / Full text
Atrx deficiency induces telomere dysfunction, endocrine defects, and reduced life span. / 05.2013 / PubMed / Full text

CBL

Effects of cerebrolysin on nerve growth factor system in the aging rat brain. / 2017 / PubMed / Full text
Skeletal Muscle CAP Expression Increases after Dietary Restriction and Aerobic Training in Women with a History of Gestational Diabetes. / 2016 / PubMed / Full text
Intranasal Cerebrolysin Attenuates Learning and Memory Impairments in D-galactose-Induced Senescence in Mice. / 01.2017 / PubMed / Full text
Neuroprotective effects of Cerebrolysin in triple repeat Tau transgenic model of Pick's disease and fronto-temporal tauopathies. / 26.11.2015 / PubMed / Full text
Cerebrolysin Accelerates Metamorphosis and Attenuates Aging-Accelerating Effect of High Temperature in Drosophila Melanogaster. / 01.10.2014 / PubMed / Full text
Cerebrolysin™ efficacy in a transgenic model of tauopathy: role in regulation of mitochondrial structure. / 21.07.2014 / PubMed / Full text
Association analyses of insulin signaling pathway gene polymorphisms with healthy aging and longevity in Americans of Japanese ancestry. / 03.2014 / PubMed / Full text

CCL20

Assessment of neuroinflammation in the aging hippocampus using large-molecule microdialysis: Sex differences and role of purinergic receptors. / 07.11.2020 / PubMed / Full text
p53 and p53-related mediators PAI-1 and IGFBP-3 are downregulated in peripheral blood mononuclear cells of HIV-patients exposed to non-nucleoside reverse transcriptase inhibitors. / 06.2020 / PubMed / Full text
Effects of the Consumption of Milk Biofortified with Selenium, Vitamin E, and Different Fatty Acid Profile on Immune Response in the Elderly. / 02.2018 / PubMed / Full text
Human Monocyte Subsets Are Transcriptionally and Functionally Altered in Aging in Response to Pattern Recognition Receptor Agonists. / 15.08.2017 / PubMed / Full text
Interferon-gamma deficiency protects against aging-related goblet cell loss. / 04.10.2016 / PubMed / Full text
Age dependent changes in the LPS induced transcriptome of bovine dermal fibroblasts occurs without major changes in the methylome. / 27.01.2015 / PubMed / Full text
Dendritic cells from aged subjects contribute to chronic airway inflammation by activating bronchial epithelial cells under steady state. / 11.2014 / PubMed / Full text

CPD

Incidental versus clinically diagnosed differentiated thyroid cancer in both adult and elderly subjects: histological characteristics and follow-up in a retrospective analysis from a single institution. / 06.2020 / PubMed / Full text
Reduced proliferation capacity of lung cells in chronic obstructive pulmonary disease. / 05.2019 / PubMed / Full text
What Do Clinical Supervisors Require to Teach Residents in Family Medicine How to Care for Seniors? / 03.2018 / PubMed / Full text
Survey of Australasian geriatricians' satisfaction with, and preferences for, continuing professional development. / 07.2016 / PubMed / Full text
The aging psychiatrist: lessons from our colleagues in surgery and anaesthesia. / 04.2016 / PubMed / Full text
Effects of donor age and proliferative aging on the phenotype stability of rat aortic smooth muscle cells. / 11.2015 / PubMed / Full text
Specificity of cytochemical and fluorescence methods of senescence-associated β-galactosidase detection for ageing driven by replication and time. / 08.2014 / PubMed / Full text

CSF1R

CSF1R blockade induces macrophage ablation and results in mouse choroidal vascular atrophy and RPE disorganization. / 01.04.2020 / PubMed / Full text
CSF1R inhibitor PLX5622 and environmental enrichment additively improve metabolic outcomes in middle-aged female mice. / 02.02.2020 / PubMed / Full text
Modulation of Microglia by Voluntary Exercise or CSF1R Inhibition Prevents Age-Related Loss of Functional Motor Units. / 05.11.2019 / PubMed / Full text
Forced turnover of aged microglia induces an intermediate phenotype but does not rebalance CNS environmental cues driving priming to immune challenge. / 26.11.2018 / PubMed / Full text
Replacement of microglia in the aged brain reverses cognitive, synaptic, and neuronal deficits in mice. / 12.2018 / PubMed / Full text
Mendelian adult-onset leukodystrophy genes in Alzheimer's disease: critical influence of CSF1R and NOTCH3. / 06.2018 / PubMed / Full text
Pleiotropic effects of extended blockade of CSF1R signaling in adult mice. / 08.2014 / PubMed / Full text

CTSB

Myocardial cathepsin D is downregulated in sudden cardiac death. / 2020 / PubMed / Full text
A Free Radical-Generating System Regulates Amyloid Oligomers: Involvement of Cathepsin B. / 2018 / PubMed / Full text
SIRT6 histone deacetylase functions as a potential oncogene in human melanoma. / 09.2017 / PubMed / Full text
Involvement of lysosomal dysfunction in autophagosome accumulation and early pathologies in adipose tissue of obese mice. / 03.04.2017 / PubMed / Full text
Running-Induced Systemic Cathepsin B Secretion Is Associated with Memory Function. / 09.08.2016 / PubMed / Full text
The association of serum cathepsin B concentration with age-related cardiovascular-renal subclinical state in a healthy Chinese population. / 07-08.2016 / PubMed / Full text
Decreased serum level of HMGB1 and MyD88 during human aging progress in healthy individuals. / 04.2016 / PubMed / Full text

CYP2E1

DNA methylation and histone acetylation changes to cytochrome P450 2E1 regulation in normal aging and impact on rates of drug metabolism in the liver. / 06.2020 / PubMed / Full text
Age-associated changes of cytochrome P450 and related phase-2 gene/proteins in livers of rats. / 2019 / PubMed / Full text
2, 3, 4', 5-tetrahydroxystilbene-2-0-β-d Glycoside Attenuates Age- and Diet-Associated Non-Alcoholic Steatohepatitis and Atherosclerosis in LDL Receptor Knockout Mice and Its Possible Mechanisms. / 01.04.2019 / PubMed / Full text
Neuroprotective Effect of Dioscin on the Aging Brain. / 30.03.2019 / PubMed / Full text
Cytochrome P450-2E1 is involved in aging-related kidney damage in mice through increased nitroxidative stress. / 11.2017 / PubMed / Full text
Cytochrome P450-2E1 promotes aging-related hepatic steatosis, apoptosis and fibrosis through increased nitroxidative stress. / 02.2016 / PubMed / Full text
Cell type-specific expression and localization of cytochrome P450 isoforms in tridimensional aggregating rat brain cell cultures. / 25.12.2015 / PubMed / Full text

DSP

Noradrenergic dysfunction accelerates LPS-elicited inflammation-related ascending sequential neurodegeneration and deficits in non-motor/motor functions. / 10.2019 / PubMed / Full text
Trade-offs in aging lung diseases: a review on shared but opposite genetic risk variants in idiopathic pulmonary fibrosis, lung cancer and chronic obstructive pulmonary disease. / 05.2018 / PubMed / Full text
Metabolic Syndrome Components Are Associated With Symptomatic Polyneuropathy Independent of Glycemic Status. / 05.2016 / PubMed / Full text
Analysis of diarrhetic shellfish poisoning toxins and pectenotoxin-2 in the bottlenose dolphin (Tursiops truncatus) by liquid chromatography-tandem mass spectrometry. / 16.10.2015 / PubMed / Full text
Telomere position effect: regulation of gene expression with progressive telomere shortening over long distances. / 15.11.2014 / PubMed / Full text
Age-dependent clinical and genetic characteristics in Japanese patients with arrhythmogenic right ventricular cardiomyopathy/dysplasia. / 2013 / PubMed / Full text
Differences in susceptibility to okadaic acid, a diarrhetic shellfish poisoning toxin, between male and female mice. / 27.12.2012 / PubMed / Full text

FIS1

Alterations in Mitochondrial Dynamic-related Genes in the Peripheral Blood of Alzheimer's Disease Patients. / 2020 / PubMed / Full text
A mitochondrial FUNDC1/HSC70 interaction organizes the proteostatic stress response at the risk of cell morbidity. / 01.02.2019 / PubMed / Full text
Increased Degradation Rates in the Components of the Mitochondrial Oxidative Phosphorylation Chain in the Cerebellum of Old Mice. / 2018 / PubMed / Full text
Proteomics and metabolomics identify molecular mechanisms of aging potentially predisposing for chronic lymphocytic leukemia. / 02.2018 / PubMed / Full text
Effects of β-hydroxy-β-methylbutyrate on skeletal muscle mitochondrial content and dynamics, and lipids after 10 days of bed rest in older adults. / 01.11.2017 / PubMed / Full text
Mitochondrial activity and dynamics changes regarding metabolism in ageing and obesity. / 03.2017 / PubMed / Full text
Inhibition of peroxisome fission, but not mitochondrial fission, increases yeast chronological lifespan. / 2015 / PubMed / Full text

FOXP3

Different expression of Defensin-B gene in the endometrium of mares of different age during the breeding season. / 21.12.2019 / PubMed / Full text
Regulatory T-cells regulate neonatal heart regeneration by potentiating cardiomyocyte proliferation in a paracrine manner. / 2019 / PubMed / Full text
Enhanced expression of PD-1 and other activation markers by CD4 T cells of young but not old patients with metastatic melanoma. / 06.2018 / PubMed / Full text
Non-linear patterns in age-related DNA methylation may reflect CD4 T cell differentiation. / 03.06.2017 / PubMed / Full text
Novel Senescent Regulatory T-Cell Subset with Impaired Suppressive Function in Rheumatoid Arthritis. / 2017 / PubMed / Full text
Age-related changes in CD4 CD25 FOXP3 regulatory T cells and their relationship with lung cancer. / 2017 / PubMed / Full text
Circulating T helper and T regulatory subsets in untreated early rheumatoid arthritis and healthy control subjects. / 10.2016 / PubMed / Full text

GAP43

HDAC inhibition leads to age-dependent opposite regenerative effect upon PTEN deletion in rubrospinal axons after SCI. / 06.2020 / PubMed / Full text
The Puzzling Role of Neuron-Specific PMCA Isoforms in the Aging Process. / 16.12.2019 / PubMed / Full text
Sonic hedgehog regulation of cavernous nerve regeneration and neurite formation in aged pelvic plexus. / 02.2019 / PubMed / Full text
Differential expression of synaptic and interneuron genes in the aging human prefrontal cortex. / 10.2018 / PubMed / Full text
Schwann Cell Phenotype Changes in Aging Human Dental Pulp. / 03.2018 / PubMed / Full text
Neurexins 1-3 Each Have a Distinct Pattern of Expression in the Early Developing Human Cerebral Cortex. / 01.01.2017 / PubMed / Full text
Alterations of Ca²⁺-responsive proteins within cholinergic neurons in aging and Alzheimer's disease. / 06.2014 / PubMed / Full text

HCN4

Structural and functional remodeling of the atrioventricular node with aging in rats: The role of hyperpolarization-activated cyclic nucleotide-gated and ryanodine 2 channels. / 05.2018 / PubMed / Full text
Age-dependent down-regulation of hyperpolarization-activated cyclic nucleotide-gated channel 4 causes deterioration of canine sinoatrial node function. / 01.05.2017 / PubMed / Full text
Characteristics of hyperpolarization-activated cyclic nucleotide-gated channels in dorsal root ganglion neurons at different ages and sizes. / 11.11.2015 / PubMed / Full text
Age-associated expression of HCN channel isoforms in rat sinoatrial node. / 02.2016 / PubMed / Full text
Altered expression of hyperpolarization-activated cyclic nucleotide-gated channels and microRNA-1 and -133 in patients with age-associated atrial fibrillation. / 09.2015 / PubMed / Full text
Differential expression of hyperpolarization-activated cyclic nucleotide-gated channel subunits during hippocampal development in the mouse. / 27.02.2015 / PubMed / Full text
Association between reversal in the expression of hyperpolarization-activated cyclic nucleotide-gated (HCN) channel and age-related atrial fibrillation. / 14.11.2014 / PubMed / Full text

HRAS

Pterostilbene Sensitizes Cisplatin-Resistant Human Bladder Cancer Cells with Oncogenic [i]HRAS[/i]. / 06.10.2020 / PubMed / Full text
Catalog of Lung Cancer Gene Mutations Among Chinese Patients. / 2020 / PubMed / Full text
How do combinations of unhealthy behaviors relate to attitudinal factors and subjective health among the adult population in the Netherlands? / 03.04.2020 / PubMed / Full text
Elucidating Proteoform Dynamics Underlying the Senescence Associated Secretory Phenotype. / 07.02.2020 / PubMed / Full text
"Back to the future": Influence of beliefs regarding the future on TTO answers. / 12.01.2016 / PubMed / Full text
Contributions of intrinsic mutation rate and selfish selection to levels of de novo HRAS mutations in the paternal germline. / 10.12.2013 / PubMed / Full text
PPARβ/δ promotes HRAS-induced senescence and tumor suppression by potentiating p-ERK and repressing p-AKT signaling. / 13.11.2014 / PubMed / Full text

IL2

Impact of Aging on the Phenotype of Invariant Natural Killer T Cells in Mouse Thymus. / 2020 / PubMed / Full text
Redox, immune and genetic biomarker system for personalized treatments in colorectal cancer. / 15.02.2019 / PubMed / Full text
Low IL-2 Expressing T Cells in Thalassemia Major Patients: Is It Immune Aging. / 10.2018 / PubMed / Full text
Epigenetic repression of interleukin 2 expression in senescent CD4 T cells during chronic HIV type 1 infection. / 01.01.2015 / PubMed / Full text
Cytomegalovirus infection modulates the phenotype and functional profile of the T-cell immune response to mycobacterial antigens in older life. / 06.2014 / PubMed / Full text
Propolis efficacy on TNF-α, IFN-γ and IL2 cytokines production in old mice with and without systemic candidiasis. / 09.2012 / PubMed / Full text
The polyfunctionality of human memory CD8 T cells elicited by acute and chronic virus infections is not influenced by age. / 2012 / PubMed / Full text

KEAP1

Sex-, age-, and race/ethnicity-dependent variations in drug-processing and NRF2-regulated genes in human livers. / 08.11.2020 / PubMed / Full text
NRF2 pathway activation by KEAP1 inhibition attenuates the manifestation of aging phenotypes in salivary glands. / 09.2020 / PubMed / Full text
Adaptation of the master antioxidant response connects metabolism, lifespan and feather development pathways in birds. / 18.05.2020 / PubMed / Full text
Inflammatory and Senescent Phenotype of Pancreatic Stellate Cells Induced by Sqstm1 Downregulation Facilitates Pancreatic Cancer Progression. / 2019 / PubMed / Full text
Systemic overexpression of SQSTM1/p62 accelerates disease onset in a SOD1 -expressing ALS mouse model. / 29.05.2018 / PubMed / Full text
Sulfur amino acid restriction-induced changes in redox-sensitive proteins are associated with slow protein synthesis rates. / 04.2018 / PubMed / Full text
The Anti-Aging Effect of Erythropoietin via the ERK/Nrf2-ARE Pathway in Aging Rats. / 03.2017 / PubMed / Full text

LRP1

Drug Targeting of Plasminogen Activator Inhibitor-1 Inhibits Metabolic Dysfunction and Atherosclerosis in a Murine Model of Metabolic Syndrome. / 06.2020 / PubMed / Full text
LXR activation protects hippocampal microvasculature in very old triple transgenic mouse model of Alzheimer's disease. / 16.05.2016 / PubMed / Full text
Rescuing effects of RXR agonist bexarotene on aging-related synapse loss depend on neuronal LRP1. / 03.2016 / PubMed / Full text
Age-Related Decline in Brain and Hepatic Clearance of Amyloid-Beta is Rectified by the Cholinesterase Inhibitors Donepezil and Rivastigmine in Rats. / 20.05.2015 / PubMed / Full text
Reduced neuronal signaling in the ageing apolipoprotein-E4 targeted replacement female mice. / 10.10.2014 / PubMed / Full text
LRP1 protects the vasculature by regulating levels of connective tissue growth factor and HtrA1. / 09.2013 / PubMed / Full text
A lipoprotein receptor cluster IV mutant preferentially binds amyloid-β and regulates its clearance from the mouse brain. / 24.05.2013 / PubMed / Full text

NOS1

Prepubertal overexposure to manganese induce precocious puberty through GABA receptor/nitric oxide pathway in immature female rats. / 30.01.2020 / PubMed / Full text
Genetic background, epigenetic factors and dietary interventions which influence human longevity. / 10.2019 / PubMed / Full text
NOS3 Inhibition Confers Post-Ischemic Protection to Young and Aging White Matter Integrity by Conserving Mitochondrial Dynamics and Miro-2 Levels. / 11.07.2018 / PubMed / Full text
NOS1 and SNAP25 polymorphisms are associated with Attention-Deficit/Hyperactivity Disorder symptoms in adults but not in children. / 04.2016 / PubMed / Full text
NOS1 induces NADPH oxidases and impairs contraction kinetics in aged murine ventricular myocytes. / 09.2015 / PubMed / Full text
Sex-dependent hypertension and renal changes in aged rats with altered renal development. / 15.08.2014 / PubMed / Full text
Common polymorphisms in nitric oxide synthase (NOS) genes influence quality of aging and longevity in humans. / 04.2013 / PubMed / Full text

NOTCH1

[How Does Aging Contribute to Cancer?] / 09.2020 / PubMed
H19 is not hypomethylated or upregulated with age or sex in the aortic valves of mice. / 10.2019 / PubMed / Full text
Age-related remodelling of oesophageal epithelia by mutated cancer drivers. / 01.2019 / PubMed / Full text
Dynamic regulation of NOTCH1 activation and Notch ligand expression in human thymus development. / 13.08.2018 / PubMed / Full text
Long telomeres protect against age-dependent cardiac disease caused by NOTCH1 haploinsufficiency. / 01.05.2017 / PubMed / Full text
Candidate gene resequencing to identify rare, pedigree-specific variants influencing healthy aging phenotypes in the long life family study. / 09.04.2016 / PubMed / Full text
Constitutive activation of NOTCH1 signaling in Sertoli cells causes gonocyte exit from quiescence. / 01.05.2013 / PubMed / Full text

NRAS

Senescent cholangiocytes release extracellular vesicles that alter target cell phenotype via the epidermal growth factor receptor. / 10.2020 / PubMed / Full text
STAT3 Relays a Differential Response to Melanoma-Associated [i]NRAS[/i] Mutations. / 02.01.2020 / PubMed / Full text
Cooperation of Dnmt3a R878H with Nras G12D promotes leukemogenesis in knock-in mice: a pilot study. / 08.11.2019 / PubMed / Full text
Sequential acquisition of mutations in myelodysplastic syndromes. / 2017 / PubMed / Full text
ETS Proto-oncogene 1 Transcriptionally Up-regulates the Cholangiocyte Senescence-associated Protein Cyclin-dependent Kinase Inhibitor 2A. / 24.03.2017 / PubMed / Full text
Trametinib radiosensitises RAS- and BRAF-mutated melanoma by perturbing cell cycle and inducing senescence. / 11.2015 / PubMed / Full text
Registered report: senescence surveillance of pre-malignant hepatocytes limits liver cancer development. / 26.01.2015 / PubMed / Full text

NTS

Neuropeptide changes in the suprachiasmatic nucleus are associated with the development of hypertension. / 08.2019 / PubMed / Full text
Aging affects isoproterenol-induced water drinking, astrocyte density, and central neuronal activation in female Brown Norway rats. / 01.08.2018 / PubMed / Full text
Neural processing of basic tastes in healthy young and older adults - an fMRI study. / 01.10.2015 / PubMed / Full text
Alterations in the Medullary Endocannabinoid System Contribute to Age-related Impairment of Baroreflex Sensitivity. / 05.2015 / PubMed / Full text
Endogenous leptin contributes to baroreflex suppression within the solitary tract nucleus of aged rats. / 01.12.2014 / PubMed / Full text
Central hydrogen sulphide mediates ventilatory responses to hypercapnia in adult conscious rats. / 11.2014 / PubMed / Full text
Chronic intermittent hypoxia promotes expression of 3-mercaptopyruvate sulfurtransferase in adult rat medulla oblongata. / 12.2013 / PubMed / Full text

OGT

ELT-2 promotes O-GlcNAc transferase OGT-1 expression to modulate Caenorhabditis elegans lifespan. / 06.07.2020 / PubMed / Full text
Neuronal O-GlcNAcylation Improves Cognitive Function in the Aged Mouse Brain. / 21.10.2019 / PubMed / Full text
Schwann cell O-GlcNAcylation promotes peripheral nerve remyelination via attenuation of the AP-1 transcription factor JUN. / 31.07.2018 / PubMed / Full text
O-GlcNAcylation of SKN-1 modulates the lifespan and oxidative stress resistance in Caenorhabditis elegans. / 08.03.2017 / PubMed / Full text
O-linked N-acetylglucosamine transferase (OGT) interacts with the histone chaperone HIRA complex and regulates nucleosome assembly and cellular senescence. / 07.06.2016 / PubMed / Full text
Disruption of O-linked N-Acetylglucosamine Signaling Induces ER Stress and β Cell Failure. / 22.12.2015 / PubMed / Full text
OGT and OGA expression in postmenopausal skeletal muscle associates with hormone replacement therapy and muscle cross-sectional area. / 12.2013 / PubMed / Full text

P2RY12

Potential caveats of putative microglia-specific markers for assessment of age-related cerebrovascular neuroinflammation. / 01.12.2020 / PubMed / Full text
Microglial changes in the early aging stage in a healthy retina and an experimental glaucoma model. / 2020 / PubMed / Full text
Patterns of Expression of Purinergic Receptor P2RY12, a Putative Marker for Non-Activated Microglia, in Aged and Alzheimer's Disease Brains. / 20.01.2020 / PubMed / Full text
Age Influences Microglial Activation After Cuprizone-Induced Demyelination. / 2018 / PubMed / Full text
Dexamethasone Induces a Specific Form of Ramified Dysfunctional Microglia. / 02.2019 / PubMed / Full text
Transcriptomic analysis of purified human cortical microglia reveals age-associated changes. / 08.2017 / PubMed / Full text
Loss of 'homeostatic' microglia and patterns of their activation in active multiple sclerosis. / 01.07.2017 / PubMed / Full text

PCSK9

Lipoprotein removal mechanisms and aging: implications for the cardiovascular health of the elderly. / 04.2020 / PubMed / Full text
The role of proprotein convertase subtilisin-kexin type 9 (PCSK9) in the vascular aging process - is there a link? / 10.2019 / PubMed / Full text
PCSK9 Inhibitors Show Value for Patients and the US Health Care System. / 12.2017 / PubMed / Full text
Association between lipoprotein (a) and proprotein convertase substilisin/kexin type 9 in patients with heterozygous familial hypercholesterolemia: A case-control study. / 02.2018 / PubMed / Full text
What's next for dyslipidemia management? The 2013 ACC/AHA Guidelines, the NLA recommendations, and beyond. / 05-06.2016 / PubMed / Full text
Impact of age and sex on the development of atherosclerosis and expression of the related genes in apoE deficient mice. / 15.01.2016 / PubMed / Full text
[[PCSK9]]: a key modulator of cardiovascular health. / 14.03.2014 / PubMed / Full text

PIK3CA

Catalog of Lung Cancer Gene Mutations Among Chinese Patients. / 2020 / PubMed / Full text
Myocyte enhancer factor 2A delays vascular endothelial cell senescence by activating the PI3K/p-Akt/SIRT1 pathway. / 10.06.2019 / PubMed / Full text
Oncogenic mutations in histologically normal endometrium: the new normal? / 10.2019 / PubMed / Full text
A clinical trial of somatic and germline analyses for healthy longevity in a postoperative cancer patient. / 09.2019 / PubMed / Full text
Membrane metallo-endopeptidase mediates cellular senescence induced by oncogenic PIK3CA accompanied with pro-tumorigenic secretome. / 01.08.2019 / PubMed / Full text
Therapeutic and preventive effects of exercise on cardiometabolic parameters in aging and obese rats. / 02.2019 / PubMed / Full text
Coordinated Expression of Phosphoinositide Metabolic Genes during Development and Aging of Human Dorsolateral Prefrontal Cortex. / 2015 / PubMed / Full text

PYY

Age- and diet-specific effects of chronic exposure to chlorpyrifos on hormones, inflammation and gut microbiota in rats. / 09.2019 / PubMed / Full text
Peptide YY (PYY) Is Expressed in Human Skeletal Muscle Tissue and Expanding Human Muscle Progenitor Cells. / 2019 / PubMed / Full text
Peptide YY induces characteristic meal patterns of aged mice. / 11.2017 / PubMed / Full text
Effects of randomized whey-protein loads on energy intake, appetite, gastric emptying, and plasma gut-hormone concentrations in older men and women. / 09.2017 / PubMed / Full text
Glucagon-like peptide-1 (GLP-1) increases in plasma and colon tissue prior to estrus and circulating levels change with increasing age in reproductively competent Wistar rats. / 04.2017 / PubMed / Full text
Increased peptide YY blood concentrations, not decreased acyl-ghrelin, are associated with reduced hunger and food intake in healthy older women: Preliminary evidence. / 01.10.2016 / PubMed / Full text
Anorexigenic postprandial responses of PYY and GLP1 to slow ice cream consumption: preservation in obese adolescents, but not in obese adults. / 03.2013 / PubMed / Full text

RIPK3

Casein kinase 1G2 suppresses necroptosis-promoted testis aging by inhibiting receptor-interacting kinase 3. / 18.11.2020 / PubMed / Full text
Crucial role of the terminal complement complex in chondrocyte death and hypertrophy after cartilage trauma. / 05.2020 / PubMed / Full text
Metformin mediates cardioprotection against aging-induced ischemic necroptosis. / 02.2020 / PubMed / Full text
A small molecule Nec-1 directly induces amyloid clearance in the brains of aged APP/PS1 mice. / 12.03.2019 / PubMed / Full text
RIP kinases as modulators of inflammation and immunity. / 09.2018 / PubMed / Full text
Necroptosis increases with age and is reduced by dietary restriction. / 08.2018 / PubMed / Full text
RIPK1-RIPK3-MLKL-dependent necrosis promotes the aging of mouse male reproductive system. / 15.08.2017 / PubMed / Full text

ROCK1

Disruption of both ROCK1 and ROCK2 genes in cardiomyocytes promotes autophagy and reduces cardiac fibrosis during aging. / 06.2019 / PubMed / Full text
Sonic hedgehog regulation of cavernous nerve regeneration and neurite formation in aged pelvic plexus. / 02.2019 / PubMed / Full text
Vascular Smooth Muscle Contractile Function Declines With Age in Skeletal Muscle Feed Arteries. / 2018 / PubMed / Full text
Reduced corporal fibrosis to protect erectile function by inhibiting the Rho-kinase/LIM-kinase/cofilin pathway in the aged transgenic rat harboring human tissue kallikrein 1. / 01-02.2017 / PubMed / Full text
Rho-associated kinase (ROCK) function is essential for cell cycle progression, senescence and tumorigenesis. / 14.01.2016 / PubMed / Full text
Inverse relationship of Rho kinase and myosin-light chain kinase expression in the aging human detrusor smooth muscle. / 15.10.2015 / PubMed / Full text
miR-135a modulates tendon stem/progenitor cell senescence via suppressing ROCK1. / 02.2015 / PubMed / Full text

RUNX1

RUNX-mediated growth arrest and senescence are attenuated by diverse mechanisms in cells expressing RUNX1 fusion oncoproteins. / 03.2018 / PubMed / Full text
Sequential acquisition of mutations in myelodysplastic syndromes. / 2017 / PubMed / Full text
Conversion of adult endothelium to immunocompetent haematopoietic stem cells. / 25.05.2017 / PubMed / Full text
Resistance Training Enhances Skeletal Muscle Innervation Without Modifying the Number of Satellite Cells or their Myofiber Association in Obese Older Adults. / 10.2016 / PubMed / Full text
Epigenetic Aging Signatures Are Coherently Modified in Cancer. / 06.2015 / PubMed / Full text
Microglia recapitulate a hematopoietic master regulator network in the aging human frontal cortex. / 08.2015 / PubMed / Full text
Runx3 deficiency results in myeloproliferative disorder in aged mice. / 25.07.2013 / PubMed / Full text

SET

Two conserved epigenetic regulators prevent healthy ageing. / 03.2020 / PubMed / Full text
Chromatin Modifiers SET-25 and SET-32 Are Required for Establishment but Not Long-Term Maintenance of Transgenerational Epigenetic Inheritance. / 20.11.2018 / PubMed / Full text
SET-9 and SET-26 are H3K4me3 readers and play critical roles in germline development and longevity. / 01.05.2018 / PubMed / Full text
Muscle-Specific Histone H3K36 Dimethyltransferase SET-18 Shortens Lifespan of Caenorhabditis elegans by Repressing daf-16a Expression. / 06.03.2018 / PubMed / Full text
Assessing efficacy of day 3 embryo time-lapse algorithms retrospectively: impacts of dataset type and confounding factors. / 09.2019 / PubMed / Full text
CONSTANCES: a general prospective population-based cohort for occupational and environmental epidemiology: cohort profile. / 01.2017 / PubMed / Full text
A non-canonical role for the C. elegans dosage compensation complex in growth and metabolic regulation downstream of TOR complex 2. / 09.2013 / PubMed / Full text

SLA

Vaccination of aged mice with adjuvanted recombinant influenza nucleoprotein enhances protective immunity. / 14.07.2020 / PubMed / Full text
Mechanical Anisotropy and Surface Roughness in Additively Manufactured Parts Fabricated by Stereolithography (SLA) Using Statistical Analysis. / 30.05.2020 / PubMed / Full text
The Effect of Age of Titanium Dental Implants on Implant Survival and Marginal Bone Resorption: A 5-Year Retrospective Follow-Up Study. / 01.10.2020 / PubMed / Full text
"Spirometric" lung age reference equations: A narrative review. / 01.2018 / PubMed / Full text
Relative growth rate in phylogenetically related deciduous and evergreen woody species. / 07.2001 / PubMed / Full text
Leaf lifespan as a determinant of leaf structure and function among 23 amazonian tree species. / 03.1991 / PubMed / Full text
The Performance of Titanium-Zirconium Implants in the Elderly: A Biomechanical Comparative Study in the Minipig. / 12.2016 / PubMed / Full text

SLC6A4

The Psilocybin-Telomere Hypothesis: An empirically falsifiable prediction concerning the beneficial neuropsychopharmacological effects of psilocybin on genetic aging. / 01.2020 / PubMed / Full text
Epigenetics-by-sex interaction for somatization conferred by methylation at the promoter region of SLC6A4 gene. / 08.03.2019 / PubMed / Full text
Proteomics and metabolomics identify molecular mechanisms of aging potentially predisposing for chronic lymphocytic leukemia. / 02.2018 / PubMed / Full text
DNA methylation and single nucleotide variants in the brain-derived neurotrophic factor (BDNF) and oxytocin receptor (OXTR) genes are associated with anxiety/depression in older women. / 2015 / PubMed / Full text
Role of the serotonin transporter gene locus in the response to SSRI treatment of major depressive disorder in late life. / 05.2015 / PubMed / Full text
The Impact of Genetics on Physical Resilience and Successful Aging. / 09.2015 / PubMed / Full text
Serotonin transporter polymorphism modifies the association between depressive symptoms and sleep onset latency complaint in elderly people: results from the 'InveCe.Ab' study. / 04.2015 / PubMed / Full text

SRC

Age-dependent loss of adipose Rubicon promotes metabolic disorders via excess autophagy. / 18.08.2020 / PubMed / Full text
Metabolic characteristics of CD8 T cell subsets in young and aged individuals are not predictive of functionality. / 05.06.2020 / PubMed / Full text
Overexpression of steroid receptor coactivators alleviates hyperglycemia-induced endothelial cell injury in rats through activating the PI3K/Akt pathway. / 05.2019 / PubMed / Full text
Integrative Analysis of Hippocampus Gene Expression Profiles Identifies Network Alterations in Aging and Alzheimer's Disease. / 2018 / PubMed / Full text
Genetic and Environmental Models of Circadian Disruption Link SRC-2 Function to Hepatic Pathology. / 10.2016 / PubMed / Full text
Conflict-Specific Aging Effects Mainly Manifest in Early Information Processing Stages-An ERP Study with Different Conflict Types. / 2016 / PubMed / Full text
Investigating the stability of mcDESPOT myelin water fraction values derived using a stochastic region contraction approach. / 01.2015 / PubMed / Full text

SRM

[Geriatric specificities of localized renal cell carcinoma]. / 11.2019 / PubMed / Full text
A targeted proteomic assay for the measurement of plasma proteoforms related to human aging phenotypes. / 08.2017 / PubMed / Full text
The effect of tone-vocoding on spatial release from masking for old, hearing-impaired listeners. / 04.2017 / PubMed / Full text
The role of early and late reflections on spatial release from masking: Effects of age and hearing loss. / 03.2017 / PubMed / Full text
Cortical Measures of Binaural Processing Predict Spatial Release from Masking Performance. / 2017 / PubMed / Full text
Release from masking for small spatial separations: Effects of age and hearing loss. / 07.2016 / PubMed / Full text
Postovulatory aging affects dynamics of mRNA, expression and localization of maternal effect proteins, spindle integrity and pericentromeric proteins in mouse oocytes. / 01.2016 / PubMed / Full text

TAT

Screening for a suitable cell membrane anchoring tag for Pseudomonas aeruginosa and applying it in cell membrane real-time tracking to investigate membrane aging. / 08.2020 / PubMed / Full text
Internalization of the TAT-PBX1 fusion protein significantly enhances the proliferation of human hair follicle-derived mesenchymal stem cells and delays their senescence. / 10.2020 / PubMed / Full text
Mitochondrial Quality Control in Aging and Heart Failure: Influence of Ketone Bodies and Mitofusin-Stabilizing Peptides. / 2019 / PubMed / Full text
Effects of HIV-1 gp120 and TAT-derived microvesicles on endothelial cell function. / 01.05.2019 / PubMed / Full text
Sumoylation-deficient Prdx6 gains protective function by amplifying enzymatic activity and stability and escapes oxidative stress-induced aberrant Sumoylation. / 05.01.2017 / PubMed / Full text
Characteristics, tissue-specific expression, and hormonal regulation of expression of tyrosine aminotransferase in the avian female reproductive tract. / 10.2016 / PubMed / Full text
Nanog induces suppression of senescence through downregulation of p27KIP1 expression. / 01.03.2016 / PubMed / Full text

TPP1

TPP1 Enhances the Therapeutic Effects of Transplanted Aged Mesenchymal Stem Cells in Infarcted Hearts via the MRE11/AKT Pathway. / 2020 / PubMed / Full text
FBW7 Mediates Senescence and Pulmonary Fibrosis through Telomere Uncapping. / 03.11.2020 / PubMed / Full text
Gemfibrozil, food and drug administration-approved lipid-lowering drug, increases longevity in mouse model of late infantile neuronal ceroid lipofuscinosis. / 05.2017 / PubMed / Full text
Shelterin Telomere Protection Protein 1 Reduction Causes Telomere Attrition and Cellular Senescence via Sirtuin 1 Deacetylase in Chronic Obstructive Pulmonary Disease. / 01.2017 / PubMed / Full text
Increased expression of telomere-regulating genes in endurance athletes with long leukocyte telomeres. / 15.01.2016 / PubMed / Full text
SIRT1 ameliorates age-related senescence of mesenchymal stem cells via modulating telomere shelterin. / 2014 / PubMed / Full text
Essential role for the TRF2 telomere protein in adult skin homeostasis. / 08.2014 / PubMed / Full text

TRIM59

DNA methylation of the ELOVL2, FHL2, KLF14, C1orf132/MIR29B2C, and TRIM59 genes for age prediction from blood, saliva, and buccal swab samples. / 01.2019 / PubMed / Full text
Proof of concept study of age-dependent DNA methylation markers across different tissues by massive parallel sequencing. / 09.2018 / PubMed / Full text
Chronological age prediction based on DNA methylation: Massive parallel sequencing and random forest regression. / 11.2017 / PubMed / Full text
DNA methylation in ELOVL2 and C1orf132 correctly predicted chronological age of individuals from three disease groups. / 01.2018 / PubMed / Full text
Independent validation of DNA-based approaches for age prediction in blood. / 07.2017 / PubMed / Full text
Donor age and C1orf132/MIR29B2C determine age-related methylation signature of blood after allogeneic hematopoietic stem cell transplantation. / 2016 / PubMed / Full text
Development of a forensically useful age prediction method based on DNA methylation analysis. / 07.2015 / PubMed / Full text

TSC1

[i]Tsc1[/i] Regulates the Proliferation Capacity of Bone-Marrow Derived Mesenchymal Stem Cells. / 10.09.2020 / PubMed / Full text
mTORC1 underlies age-related muscle fiber damage and loss by inducing oxidative stress and catabolism. / 06.2019 / PubMed / Full text
FTO is involved in Alzheimer's disease by targeting TSC1-mTOR-Tau signaling. / 25.03.2018 / PubMed / Full text
Postnatal reduction of tuberous sclerosis complex 1 expression in astrocytes and neurons causes seizures in an age-dependent manner. / 12.2017 / PubMed / Full text
Moderate lifelong overexpression of tuberous sclerosis complex 1 (TSC1) improves health and survival in mice. / 11.04.2017 / PubMed / Full text
mTOR inactivation by ROS-JNK-p53 pathway plays an essential role in psedolaric acid B induced autophagy-dependent senescence in murine fibrosarcoma L929 cells. / 05.09.2013 / PubMed / Full text
Timing of mTOR activation affects tuberous sclerosis complex neuropathology in mouse models. / 09.2013 / PubMed / Full text

UCP3

Altered miRNA and mRNA Expression in Sika Deer Skeletal Muscle with Age. / 06.02.2020 / PubMed / Full text
Age-related sex differences in the expression of important disease-linked mitochondrial proteins in mice. / 05.12.2019 / PubMed / Full text
Integrated study on comparative transcriptome and skeletal muscle function in aged rats. / 01.2018 / PubMed / Full text
Pleiotropic effects of UCP2-UCP3 variability on leucocyte telomere length and glucose homeostasis. / 06.2017 / PubMed / Full text
Single nucleotide polymorphisms linked to mitochondrial uncoupling protein genes UCP2 and UCP3 affect mitochondrial metabolism and healthy aging in female nonagenarians. / 08.2016 / PubMed / Full text
[Genotype and allele frequencies of UCP and PPAR gene families in residents of besieged Leningrad and in the control group]. / 2014 / PubMed
Contribution of genetic polymorphisms on functional status at very old age: a gene-based analysis of 38 genes (311 SNPs) in the oxidative stress pathway. / 04.2014 / PubMed / Full text

XPC

MicroRNA binding mediated Functional sequence variant in 3'-UTR of DNA repair Gene XPC in Age-related Cataract. / 12.10.2018 / PubMed / Full text
Global-genome Nucleotide Excision Repair Controlled by Ubiquitin/Sumo Modifiers. / 2016 / PubMed / Full text
Xeroderma pigmentosum group C sensor: unprecedented recognition strategy and tight spatiotemporal regulation. / 02.2016 / PubMed / Full text
Lifespan and Stress Resistance in Drosophila with Overexpressed DNA Repair Genes. / 19.10.2015 / PubMed / Full text
[Role of DNA repair genes in radiation-induced changes of lifespan of Drosophila melanogaster]. / 09-10.2014 / PubMed
Defective mitophagy in XPA via PARP-1 hyperactivation and NAD( )/SIRT1 reduction. / 08.05.2014 / PubMed / Full text
Postprandial activation of p53-dependent DNA repair is modified by Mediterranean diet supplemented with coenzyme Q10 in elderly subjects. / 07.2014 / PubMed / Full text

ABCA7

New genetic players in late-onset Alzheimer's disease: Findings of genome-wide association studies. / 08.2018 / PubMed / Full text
Whole-Exome Sequencing of an Exceptional Longevity Cohort. / 16.08.2019 / PubMed / Full text
Recent studies on cellular and molecular mechanisms in Alzheimer's disease: focus on epigenetic factors and histone deacetylase. / 28.03.2018 / PubMed / Full text
Late Onset Alzheimer's Disease Risk Variants in Cognitive Decline: The PATH Through Life Study. / 2017 / PubMed / Full text
Association and interaction effects of Alzheimer's disease-associated genes and lifestyle on cognitive aging in older adults in a Taiwanese population. / 11.04.2017 / PubMed / Full text
Gene-based aggregate SNP associations between candidate AD genes and cognitive decline. / 04.2016 / PubMed / Full text

ADAM17

ACE2/ADAM17/TMPRSS2 Interplay May Be the Main Risk Factor for COVID-19. / 2020 / PubMed / Full text
DNA methylation analysis on purified neurons and glia dissects age and Alzheimer's disease-specific changes in the human cortex. / 25.07.2018 / PubMed / Full text
Role of Adipose Tissue Endothelial ADAM17 in Age-Related Coronary Microvascular Dysfunction. / 06.2017 / PubMed / Full text
Selective Inhibition of ADAM17 Efficiently Mediates Glycoprotein Ibα Retention During Ex Vivo Generation of Human Induced Pluripotent Stem Cell-Derived Platelets. / 03.2017 / PubMed / Full text
[The effect of PNS on the content and activity of alpha-secretase in the brains of SAMP8 mice with alzheimer's disease]. / 11.2012 / PubMed
Endothelial deletion of ADAM17 in mice results in defective remodeling of the semilunar valves and cardiac dysfunction in adults. / 04-05.2013 / PubMed / Full text

AFP

Effect of Alpha-Fetoprotein on Lifespan of Old Mice. / 12.2016 / PubMed / Full text
Correlation between vitamin D levels and apoptosis in geriatric patients infected with hepatitis C virus genotype 4. / 2016 / PubMed / Full text
A new paradigm about HERV-K102 particle production and blocked release to explain cortisol mediated immunosenescence and age-associated risk of chronic disease. / 12.2015 / PubMed
Are Performance Measures Necessary to Predict Loss of Independence in Elderly People? / 01.2016 / PubMed / Full text
Proteomic biomarkers for ageing the mosquito Aedes aegypti to determine risk of pathogen transmission. / 2013 / PubMed / Full text
Effect of vocal nerve section on song and ZENK protein expression in area X in adult male zebra finches. / 2012 / PubMed / Full text

AMT

A multi-method comparison of autobiographical memory impairments amongst younger and older adults. / 12.03.2020 / PubMed / Full text
Autobiographical Memory From Different Life Stages in Individuals With Obstructive Sleep Apnea. / 03.2019 / PubMed / Full text
Fatigue in Younger and Older Drivers: Effectiveness of an Alertness-Maintaining Task. / 09.2017 / PubMed / Full text
Reduced specificity and enhanced subjective experience of future thinking in ageing: the influence of avoidance and emotion-regulation strategies. / 01.2018 / PubMed / Full text
Evaluation of delirium screening tools in geriatric medical inpatients: a diagnostic test accuracy study. / 11.2016 / PubMed / Full text
Falls and other geriatric syndromes in Blantyre, Malawi: a community survey of older adults. / 12.2014 / PubMed / Full text

AQP1

Blue Light Induces Down-Regulation of Aquaporin 1, 3, and 9 in Human Keratinocytes. / 03.11.2018 / PubMed / Full text
[Age-related changes of water transport by corneal endothelial cells in rats.] / 2017 / PubMed
Investigation of the effects of aging on the expression of aquaporin 1 and aquaporin 4 protein in heart tissue. / 01.2017 / PubMed / Full text
Seasonal and Ageing-Depending Changes of Aquaporins 1 and 9 Expression in the Genital Tract of Buffalo Bulls (Bubalus bubalis). / 08.2016 / PubMed / Full text
Investigation of age-related changes in the expression of aquaporin-1 and aquaporin-5 in the salivary glands of mice. / 09.2016 / PubMed / Full text
The effects of high doses of nandrolone decanoate and exercise on prostate microvasculature of adult and older rats. / 15.01.2015 / PubMed / Full text

ASPA

Effect of adding B-vitamins to vitamin D and calcium supplementation on CpG methylation of epigenetic aging markers. / 04.2018 / PubMed / Full text
Development of a methylation marker set for forensic age estimation using analysis of public methylation data and the Agena Bioscience EpiTYPER system. / 09.2016 / PubMed / Full text
Epigenetic age predictions based on buccal swabs are more precise in combination with cell type-specific DNA methylation signatures. / 05.2016 / PubMed / Full text
Plasma Amyloid Beta 1-42 and DNA Methylation Pattern Predict Accelerated Aging in Young Subjects with Down Syndrome. / 12.2016 / PubMed / Full text
Developing a DNA methylation assay for human age prediction in blood and bloodstain. / 07.2015 / PubMed / Full text
Aging of blood can be tracked by DNA methylation changes at just three CpG sites. / 03.02.2014 / PubMed / Full text

BID

Dabigatran etexilate: appropriate use in patients with chronic kidney disease and in the elderly patients. / 06.2017 / PubMed / Full text
Sperm-associated antigen 9 (SPAG9) promotes the survival and tumor growth of triple-negative breast cancer cells. / 10.2016 / PubMed / Full text
Rationale for the Assessment of Metoprolol in the Prevention of Vasovagal Syncope in Aging Subjects Trial (POST5). / 04.2016 / PubMed / Full text
The geriatric mania asenapine study (GeMS). / 05-06.2016 / PubMed / Full text
The effect of aging on mitochondrial and cytosolic hepatic intrinsic death pathway and apoptosis associated proteins in Fischer 344 rats. / 07.2015 / PubMed / Full text
Neuroimmunomodulation and aging: a role for transferrin and the hypothalamus/thymus axis. / 02.2013 / PubMed / Full text

BMF

Treatment-Induced Tumor Dormancy through YAP-Mediated Transcriptional Reprogramming of the Apoptotic Pathway. / 13.01.2020 / PubMed / Full text
lncRNA-ES3/miR-34c-5p/BMF axis is involved in regulating high-glucose-induced calcification/senescence of VSMCs. / 17.01.2019 / PubMed / Full text
Aging, hematopoiesis, and the myelodysplastic syndromes. / 08.12.2017 / PubMed / Full text
Bone marrow fat unsaturation in young adults is not affected by present or childhood obesity, but increases with age: A pilot study. / 11.2015 / PubMed / Full text
Loss of the proapoptotic BH3-only protein BCL-2 modifying factor prolongs the fertile life span in female mice. / 04.2014 / PubMed / Full text
Comparison of vertebral bone marrow fat assessed by 1H MRS and inphase and out-of-phase MRI among family members. / 02.2014 / PubMed / Full text

BMP15

Prediction of ovarian aging using ovarian expression of BMP15, GDF9, and C-KIT. / 04.2020 / PubMed / Full text
Single xenotransplant of rat brown adipose tissue prolonged the ovarian lifespan of aging mice by improving follicle survival. / 12.2019 / PubMed / Full text
Antioxidant hesperetin improves the quality of porcine oocytes during aging in vitro. / 01.2019 / PubMed / Full text
Observation of the influences of diosgenin on aging ovarian reserve and function in a mouse model. / 18.10.2017 / PubMed / Full text
Effects of aging on gene expression and mitochondrial DNA in the equine oocyte and follicle cells. / 07.2015 / PubMed / Full text
Interactions between genetic variants in AMH and [[AMHR2]] may modify age at natural menopause. / 2013 / PubMed / Full text

BRD4

Inhibition of BRD4 triggers cellular senescence through suppressing aurora kinases in oesophageal cancer cells. / 20.09.2020 / PubMed / Full text
BRD4 contributes to LPS-induced macrophage senescence and promotes progression of atherosclerosis-associated lipid uptake. / 11.05.2020 / PubMed / Full text
BET Proteins Are Required for Transcriptional Activation of the Senescent Islet Cell Secretome in Type 1 Diabetes. / 26.09.2019 / PubMed / Full text
Interference with the bromodomain epigenome readers drives p21 expression and tumor senescence. / 01.10.2019 / PubMed / Full text
Neuroprotective effects of targeting BET proteins for degradation with dBET1 in aged mice subjected to ischemic stroke. / 07.2019 / PubMed / Full text
Bromodomain and Extraterminal Protein Inhibition Blocks Growth of Triple-negative Breast Cancers through the Suppression of Aurora Kinases. / 04.11.2016 / PubMed / Full text

CCR6

Age-associated antigen-presenting cell alterations promote dry-eye inducing Th1 cells. / 07.2019 / PubMed / Full text
Age-related but not longevity-related genes are found by weighted gene co-expression network analysis in the peripheral blood cells of humans. / 19.01.2019 / PubMed / Full text
Circulating T helper and T regulatory subsets in untreated early rheumatoid arthritis and healthy control subjects. / 10.2016 / PubMed / Full text
Double negative (IgG IgD-CD27-) B cells are increased in a cohort of moderate-severe Alzheimer's disease patients and show a pro-inflammatory trafficking receptor phenotype. / 2015 / PubMed / Full text
Trafficking phenotype and production of granzyme B by double negative B cells (IgG( )IgD(-)CD27(-)) in the elderly. / 06.2014 / PubMed / Full text
Increased Th17 differentiation in aged mice is significantly associated with high IL-1β level and low IL-2 expression. / 01.2014 / PubMed / Full text

CD74

Identification of a conserved gene signature associated with an exacerbated inflammatory environment in the hippocampus of aging rats. / 04.2017 / PubMed / Full text
Intramembrane proteolysis within lysosomes. / 12.2016 / PubMed / Full text
Proton irradiation impacts age-driven modulations of cancer progression influenced by immune system transcriptome modifications from splenic tissue. / 09.2015 / PubMed / Full text
Macrophage migration inhibitory factor confers resistance to senescence through CD74-dependent AMPK-FOXO3a signaling in mesenchymal stem cells. / 22.04.2015 / PubMed / Full text
Macrophage migration inhibitory factor deficiency in chronic obstructive pulmonary disease. / 15.03.2014 / PubMed / Full text
Effects of minocycline on spatial learning, hippocampal neurogenesis and microglia in aged and adult mice. / 01.04.2013 / PubMed / Full text

CDC42

Effects of age-dependent changes in cell size on endothelial cell proliferation and senescence through YAP1. / 05.09.2019 / PubMed / Full text
Re-exploring the core genes and modules in the human frontal cortex during chronological aging: insights from network-based analysis of transcriptomic studies. / 20.10.2018 / PubMed / Full text
The relationship between reproductive and biochemical ageing at the time of the menopausal transition. / 11.2017 / PubMed / Full text
Senescent cells communicate via intercellular protein transfer. / 15.04.2015 / PubMed / Full text
A crucial role for CDC42 in senescence-associated inflammation and atherosclerosis. / 2014 / PubMed / Full text
LOX-1 in the maintenance of cytoskeleton and proliferation in senescent cardiac fibroblasts. / 07.2013 / PubMed / Full text

CTNNB1

Catalog of Lung Cancer Gene Mutations Among Chinese Patients. / 2020 / PubMed / Full text
[i]TP53[/i] Tumor-suppressor Gene Plays a Key Role in IGF1 Signaling Pathway Related to the Aging of Human Melanocytes. / 05.2019 / PubMed / Full text
Identification of key genes and transcription factors in aging mesenchymal stem cells by DNA microarray data. / 15.04.2019 / PubMed / Full text
Proteomic profiling of follicle fluids after superstimulation in one-month-old lambs. / 02.2018 / PubMed / Full text
P4 medicine and osteoporosis: a systematic review. / 12.2016 / PubMed / Full text
Expression profile analysis of new candidate genes for the therapy of primary osteoporosis. / 2016 / PubMed

CYP11A1

Prepubertal exposure to perfluorononanoic acid interferes with spermatogenesis and steroidogenesis in male mice. / 15.04.2019 / PubMed / Full text
Morphological rearrangement of the cortical region, in aging ovaries. / 07.2019 / PubMed / Full text
Peroxiredoxin 2 deficiency accelerates age-related ovarian failure through the reactive oxygen species-mediated JNK pathway in mice. / 01.08.2018 / PubMed / Full text
Systemic analysis of gene expression profiles in porcine granulosa cells during aging. / 14.11.2017 / PubMed / Full text
Combined toxicity of endosulfan and phenanthrene mixtures and induced molecular changes in adult Zebrafish (Danio rerio). / 03.2018 / PubMed / Full text
Testicular gene expression of steroidogenesis-related factors in prepubertal, postpubertal, and aging dogs. / 01.03.2017 / PubMed / Full text

CYP17A1

Intratumoral heterogeneity of the tumor cells based on in situ cortisol excess in cortisol-producing adenomas; ∼An association among morphometry, genotype and cellular senescence∼. / 11.2020 / PubMed / Full text
Combined toxicity of endosulfan and phenanthrene mixtures and induced molecular changes in adult Zebrafish (Danio rerio). / 03.2018 / PubMed / Full text
Testicular gene expression of steroidogenesis-related factors in prepubertal, postpubertal, and aging dogs. / 01.03.2017 / PubMed / Full text
CYP17A1 Enzyme Activity Is Linked to Ambulatory Blood Pressure in a Family-Based Population Study. / 04.2016 / PubMed / Full text
Sequence analysis of six blood pressure candidate regions in 4,178 individuals: the Cohorts for Heart and Aging Research in Genomic Epidemiology (CHARGE) targeted sequencing study. / 2014 / PubMed / Full text
Of mice and men--warning: intact versus castrated adult male mice as xenograft hosts are equivalent to hypogonadal versus abiraterone treated aging human males, respectively. / 09.2013 / PubMed / Full text

DKK1

Low Serum Levels of DKK2 Predict Incident Low-Impact Fracture in Older Women. / 07.2019 / PubMed / Full text
Involvement of p38 in Age-Related Decline in Adult Neurogenesis via Modulation of Wnt Signaling. / 11.06.2019 / PubMed / Full text
[Role and alterations of DNA methylation during the aging and cancer]. / 01.2018 / PubMed / Full text
Melatonin regulates the aging mouse hippocampal homeostasis via the sirtuin1-FOXO1 pathway. / 2017 / PubMed / Full text
Circulating sclerostin and dickkopf-1 levels in ossification of the posterior longitudinal ligament of the spine. / 05.2016 / PubMed / Full text
Vaccination with DKK1-derived peptides promotes bone formation and bone mass in an aged mouse osteoporosis model. / 08.2014 / PubMed / Full text

FGF19

Bile acid receptor agonists in primary biliary cholangitis: Regulation of the cholangiocyte secretome and downstream T cell differentiation. / 05.2019 / PubMed / Full text
Kotho and aging. / 09.2016 / PubMed
The Klotho proteins in health and disease. / 01.2019 / PubMed / Full text
Peroxisomal Acyl-CoA Oxidase Type 1: Anti-Inflammatory and Anti-Aging Properties with a Special Emphasis on Studies with LPS and Argan Oil as a Model Transposable to Aging. / 2018 / PubMed / Full text
A Genetic Screen Identifies Hypothalamic Fgf15 as a Regulator of Glucagon Secretion. / 08.11.2016 / PubMed / Full text
A preliminary candidate approach identifies the combination of chemerin, fetuin-A, and fibroblast growth factors 19 and 21 as a potential biomarker panel of successful aging. / 06.2015 / PubMed / Full text

GCLM

Silencing Bach1 alters aging-related changes in the expression of Nrf2-regulated genes in primary human bronchial epithelial cells. / 15.09.2019 / PubMed / Full text
Ontogeny and aging of Nrf2 pathway genes in livers of rats. / 15.06.2018 / PubMed / Full text
Sulfur amino acid restriction-induced changes in redox-sensitive proteins are associated with slow protein synthesis rates. / 04.2018 / PubMed / Full text
Aging-related decline in the induction of Nrf2-regulated antioxidant genes in human bronchial epithelial cells. / 04.2018 / PubMed / Full text
Nrf2 signaling is impaired in the aging RPE given an oxidative insult. / 02.2014 / PubMed / Full text
Competition of nuclear factor-erythroid 2 factors related transcription factor isoforms, Nrf1 and Nrf2, in antioxidant enzyme induction. / 2013 / PubMed / Full text

GEM

The Impact of Geriatric Emergency Management Nurses on the Care of Frail Older Patients in the Emergency Department: a Systematic Review. / 09.2020 / PubMed / Full text
Cytosolic and mitochondrial Ca concentrations in primary hepatocytes change with ageing and in consequence of an mtDNA mutation. / 09.2019 / PubMed / Full text
Understanding of diagnosis and medications among non-English-speaking older patients. / 06.2018 / PubMed / Full text
Increased gait variability may not imply impaired stride-to-stride control of walking in healthy older adults: Winner: 2013 Gait and Clinical Movement Analysis Society Best Paper Award. / 06.2017 / PubMed / Full text
The development and evaluation of mini-GEMs - short, focused, online e-learning videos in geriatric medicine. / 04-06.2018 / PubMed / Full text
Neoplastic and nonneoplastic lesions in aging mice of unique and common inbred strains contribution to modeling of human neoplastic diseases. / 05.2014 / PubMed / Full text

GLS

Normal Values and Growth-Related Changes of Left Ventricular Volumes, Stress, and Strain in Healthy Children Measured by 3-Dimensional Echocardiography. / 15.07.2018 / PubMed / Full text
Future Perspectives for Management of Stage A Heart Failure. / 01.07.2018 / PubMed / Full text
Reference Ranges of Left Ventricular Strain Measures by Two-Dimensional Speckle-Tracking Echocardiography in Children: A Systematic Review and Meta-Analysis. / 03.2016 / PubMed / Full text
Cardiorespiratory fitness modifies the relationship between myocardial function and cerebral blood flow in older adults. / 01.05.2016 / PubMed / Full text
Left ventricular strain examination of different aged adults with 3D speckle tracking echocardiography. / 03.2014 / PubMed / Full text
Left ventricular three-dimensional global systolic strain by real-time three-dimensional speckle-tracking in children: feasibility, reproducibility, maturational changes, and normal ranges. / 08.2013 / PubMed / Full text

GSTP1

DCAF1 regulates Treg senescence via the ROS axis during immunological aging. / 02.11.2020 / PubMed / Full text
Age-associated changes in GSH S-transferase gene/proteins in livers of rats. / 12.2018 / PubMed / Full text
Lead-Related Genetic Loci, Cumulative Lead Exposure and Incident Coronary Heart Disease: The Normative Aging Study. / 2016 / PubMed / Full text
Contribution of genetic polymorphisms on functional status at very old age: a gene-based analysis of 38 genes (311 SNPs) in the oxidative stress pathway. / 04.2014 / PubMed / Full text
Epigenetic susceptibility factors for prostate cancer with aging. / 12.2013 / PubMed / Full text
The age-related change of glutathione antioxidant system in mice liver. / 07.2013 / PubMed / Full text

HAL

Comparison of haloperidol, non-haloperidol antipsychotics, and no pharmacotherapy for the management of delirium in an inpatient geriatric palliative care population. / 06-09.2018 / PubMed / Full text
Acute and long-term effects of haloperidol on surgery-induced neuroinflammation and cognitive deficits in aged rats. / 06.2019 / PubMed / Full text
Histone deacetylase inhibitors reverse age-related increases in side effects of haloperidol in mice. / 08.2017 / PubMed / Full text
Differential effects of intermittent versus continuous haloperidol treatment throughout adolescence on haloperidol sensitization and social behavior in adulthood. / 03.10.2014 / PubMed / Full text
HDAC inhibitors restore the capacity of aged mice to respond to haloperidol through modulation of histone acetylation. / 05.2014 / PubMed / Full text
Selective matrix (hyaluronan) interaction with CD44 and RhoGTPase signaling promotes keratinocyte functions and overcomes age-related epidermal dysfunction. / 10.2013 / PubMed / Full text

HBP1

Suppression of p38/HBP1 pathway alleviates hyperosmotic stress-induced senescent progression of chondrocyte senescence. / 03-04.2020 / PubMed / Full text
Transcription factor HBP1: A regulator of senescence and apoptosis of preadipocytes. / 17.09.2019 / PubMed / Full text
A positive feedback loop between Pim-1 kinase and HBP1 transcription factor contributes to hydrogen peroxide-induced premature senescence and apoptosis. / 19.05.2017 / PubMed / Full text
Focused screening of mitochondrial metabolism reveals a crucial role for a tumor suppressor Hbp1 in ovarian reserve. / 10.2016 / PubMed / Full text
HBP1-mediated Regulation of p21 Protein through the Mdm2/p53 and TCF4/EZH2 Pathways and Its Impact on Cell Senescence and Tumorigenesis. / 10.06.2016 / PubMed / Full text
Absence of AMPKα2 accelerates cellular senescence via p16 induction in mouse embryonic fibroblasts. / 02.2016 / PubMed / Full text

HCN1

Protein expression changes of HCN1 and HCN2 in hippocampal subregions of gerbils during the normal aging process. / 11.2019 / PubMed / Full text
HCN as a Mediator of Urinary Homeostasis: Age-Associated Changes in Expression and Function in Adrenergic Detrusor Relaxation. / 15.02.2019 / PubMed / Full text
Dopaminergic Neurons Exhibit an Age-Dependent Decline in Electrophysiological Parameters in the MitoPark Mouse Model of Parkinson's Disease. / 06.04.2016 / PubMed / Full text
Characteristics of hyperpolarization-activated cyclic nucleotide-gated channels in dorsal root ganglion neurons at different ages and sizes. / 11.11.2015 / PubMed / Full text
Age-associated expression of HCN channel isoforms in rat sinoatrial node. / 02.2016 / PubMed / Full text
Differential expression of hyperpolarization-activated cyclic nucleotide-gated channel subunits during hippocampal development in the mouse. / 27.02.2015 / PubMed / Full text

HDAC6

Inhibition of HDAC6 Attenuates Diabetes-Induced Retinal Redox Imbalance and Microangiopathy. / 09.07.2020 / PubMed / Full text
Cellular senescence is associated with reorganization of the microtubule cytoskeleton. / 03.2019 / PubMed / Full text
2,4‑Di‑tert‑butylphenol, a potential HDAC6 inhibitor, induces senescence and mitotic catastrophe in human gastric adenocarcinoma AGS cells. / 05.2018 / PubMed / Full text
HDAC6 Suppresses Age-Dependent Ectopic Fat Accumulation by Maintaining the Proteostasis of PLIN2 in Drosophila. / 09.10.2017 / PubMed / Full text
The Deacetylase HDAC6 Mediates Endogenous Neuritic Tau Pathology. / 29.08.2017 / PubMed / Full text
Declined Expression of Histone Deacetylase 6 Contributes to Periodontal Ligament Stem Cell Aging. / 01.2017 / PubMed / Full text

HMGA2

4D Genome Rewiring during Oncogene-Induced and Replicative Senescence. / 07.05.2020 / PubMed / Full text
The protective effects of HMGA2 in the senescence process of bone marrow-derived mesenchymal stromal cells. / 04.2020 / PubMed / Full text
Epigallocatechin-3-gallate and BIX-01294 have different impact on epigenetics and senescence modulation in acute and chronic myeloid leukemia cells. / 05.11.2018 / PubMed / Full text
Molecular differences between stromal cell populations from deciduous and permanent human teeth. / 18.04.2015 / PubMed / Full text
Rb protein is essential to the senescence-associated heterochromatic foci formation induced by HMGA2 in primary WI38 cells. / 20.08.2013 / PubMed / Full text
MYCN/LIN28B/Let-7/HMGA2 pathway implicated by meta-analysis of GWAS in suppression of post-natal proliferation thereby potentially contributing to aging. / 07-08.2013 / PubMed / Full text

HMGB2

Loss of Endogenous HMGB2 Promotes Cardiac Dysfunction and Pressure Overload-Induced Heart Failure in Mice. / 25.01.2019 / PubMed / Full text
HMGB2 Loss upon Senescence Entry Disrupts Genomic Organization and Induces CTCF Clustering across Cell Types. / 17.05.2018 / PubMed / Full text
Correlations between age, functional status, and the senescence-associated proteins HMGB2 and p16 . / 04.2018 / PubMed / Full text
Transcriptional Repression of High-Mobility Group Box 2 by p21 in Radiation-Induced Senescence. / 30.04.2018 / PubMed / Full text
Loss of Endometrial Plasticity in Recurrent Pregnancy Loss. / 02.2016 / PubMed / Full text
Quantitative proteomic profiling of tumor cell response to telomere dysfunction using isotope-coded protein labeling (ICPL) reveals interaction network of candidate senescence markers. / 08.10.2013 / PubMed / Full text

IGF2

Paternal Insulin-like Growth Factor 2 (Igf2) Regulates Stem Cell Activity During Adulthood. / 02.2017 / PubMed / Full text
Genetic variation and exercise-induced muscle damage: implications for athletic performance, injury and ageing. / 09.2016 / PubMed / Full text
Autocrine Action of IGF2 Regulates Adult β-Cell Mass and Function. / 12.2015 / PubMed / Full text
Enhanced memory consolidation in mice lacking the circadian modulators Sharp1 and -2 caused by elevated Igf2 signaling in the cortex. / 07.07.2015 / PubMed / Full text
miR-30e targets IGF2-regulated osteogenesis in bone marrow-derived mesenchymal stem cells, aortic smooth muscle cells, and ApoE-/- mice. / 01.04.2015 / PubMed / Full text
Epigenetic susceptibility factors for prostate cancer with aging. / 12.2013 / PubMed / Full text

IL4

Deficiency in Protein Tyrosine Phosphatase PTP1B Shortens Lifespan and Leads to Development of Acute Leukemia. / 01.01.2018 / PubMed / Full text
Aging Affects Bone Marrow Macrophage Polarization: Relevance to Bone Healing. / 06.2016 / PubMed / Full text
IL4/STAT6 Signaling Activates Neural Stem Cell Proliferation and Neurogenesis upon Amyloid-β42 Aggregation in Adult Zebrafish Brain. / 18.10.2016 / PubMed / Full text
IL10-driven STAT3 signalling in senescent macrophages promotes pathological eye angiogenesis. / 11.08.2015 / PubMed / Full text
LIPID PROFILE AND CYTOKINES INTERACTIONS DURING SUCCESSFUL AGING. / 06.2015 / PubMed
Ageing related periostin expression increase from cardiac fibroblasts promotes cardiomyocytes senescent. / 26.09.2014 / PubMed / Full text

IRF8

Bioinformatic characterization of angiotensin-converting enzyme 2, the entry receptor for SARS-CoV-2. / 2020 / PubMed / Full text
Hyperglycemia-induced inflamm-aging accelerates gingival senescence via NLRC4 phosphorylation. / 06.12.2019 / PubMed / Full text
IRF8 induces senescence of lung cancer cells to exert its tumor suppressive function. / 12.2019 / PubMed / Full text
Epigenome-wide exploratory study of monozygotic twins suggests differentially methylated regions to associate with hand grip strength. / 10.2019 / PubMed / Full text
Aging impairs both primary and secondary RIG-I signaling for interferon induction in human monocytes. / 12.12.2017 / PubMed / Full text
Microglia recapitulate a hematopoietic master regulator network in the aging human frontal cortex. / 08.2015 / PubMed / Full text

JAK1

Implication of JAK1/STAT3/SOCS3 Pathway in Aging of Cerebellum of Male Rat: Histological and Molecular study. / 01.06.2020 / PubMed / Full text
Irradiation-induced senescence of bone marrow mesenchymal stem cells aggravates osteogenic differentiation dysfunction via paracrine signaling. / 01.05.2020 / PubMed / Full text
The Upregulation of Toll-Like Receptor 3 via Autocrine IFN-β Signaling Drives the Senescence of Human Umbilical Cord Blood-Derived Mesenchymal Stem Cells Through JAK1. / 2019 / PubMed / Full text
Influence of age and renal impairment on the steady state pharmacokinetics of filgotinib, a selective JAK1 inhibitor. / 12.2018 / PubMed / Full text
Immunologic effects of chronic administration of tofacitinib, a Janus kinase inhibitor, in cynomolgus monkeys and rats - Comparison of juvenile and adult responses. / 04.2018 / PubMed / Full text
Interferon-γ induces senescence in normal human melanocytes. / 2014 / PubMed / Full text

KIT

Prediction of ovarian aging using ovarian expression of BMP15, GDF9, and C-KIT. / 04.2020 / PubMed / Full text
miR-19b-3p induces cell proliferation and reduces heterochromatin-mediated senescence through PLZF in goat male germline stem cells. / 06.2018 / PubMed / Full text
Comparison of Changes in the Interstitial Cells of Cajal and Neuronal Nitric Oxide Synthase-positive Neuronal Cells With Aging Between the Ascending and Descending Colon of F344 Rats. / 30.10.2017 / PubMed / Full text
Leukocyte telomere length in mastocytosis: correlations with depression and perceived stress. / 01.2014 / PubMed / Full text
Changes of number of cells expressing proliferation and progenitor cell markers with age in rabbit intervertebral discs. / 05.2013 / PubMed / Full text
Systemic mastocytosis in the elderly. / 05.2013 / PubMed / Full text

LAMP2

An In-Vitro Cell Model of Intracellular Protein Aggregation Provides Insights into RPE Stress Associated with Retinopathy. / 11.09.2020 / PubMed / Full text
Estrogen Signaling Induces Mitochondrial Dysfunction-Associated Autophagy and Senescence in Breast Cancer Cells. / 01.04.2020 / PubMed / Full text
Genetic LAMP2 deficiency accelerates the age-associated formation of basal laminar deposits in the retina. / 19.11.2019 / PubMed / Full text
SQSTM1/p62 and PPARGC1A/PGC-1alpha at the interface of autophagy and vascular senescence. / 06.2020 / PubMed / Full text
A pH probe inhibits senescence in mesenchymal stem cells. / 07.12.2018 / PubMed / Full text
Skeletal muscle from aged American Quarter Horses shows impairments in mitochondrial biogenesis and expression of autophagy markers. / 02.2018 / PubMed / Full text

MAPK1

Purified Vitexin Compound 1 Inhibits UVA-Induced Cellular Senescence in Human Dermal Fibroblasts by Binding Mitogen-Activated Protein Kinase 1. / 2020 / PubMed / Full text
Identification of key genes and transcription factors in aging mesenchymal stem cells by DNA microarray data. / 15.04.2019 / PubMed / Full text
Integrative Analysis of Hippocampus Gene Expression Profiles Identifies Network Alterations in Aging and Alzheimer's Disease. / 2018 / PubMed / Full text
iTRAQ-based proteomic profiling of granulosa cells from lamb and ewe after superstimulation. / 01.10.2017 / PubMed / Full text
Crosstalk from cAMP to ERK1/2 emerges during postnatal maturation of nociceptive neurons and is maintained during aging. / 01.07.2017 / PubMed / Full text
Maternal immune activation induces changes in myelin and metabolic proteins, some of which can be prevented with risperidone in adolescence. / 2015 / PubMed / Full text

MCU

A rare case of Epstein-Barr virus-positive mucocutaneous ulcer that developed into an intestinal obstruction: a case report. / 13.01.2020 / PubMed / Full text
Inhibition of Mitochondrial Calcium Overload by SIRT3 Prevents Obesity- or Age-Related Whitening of Brown Adipose Tissue. / 02.2020 / PubMed / Full text
Cytosolic and mitochondrial Ca concentrations in primary hepatocytes change with ageing and in consequence of an mtDNA mutation. / 09.2019 / PubMed / Full text
The nuclear receptor RXRA controls cellular senescence by regulating calcium signaling. / 12.2018 / PubMed / Full text
Physical exercise in aging human skeletal muscle increases mitochondrial calcium uniporter expression levels and affects mitochondria dynamics. / 12.2016 / PubMed / Full text
Evolution of increased adult longevity in Drosophila melanogaster populations selected for adaptation to larval crowding. / 02.2016 / PubMed / Full text

MEF2C

Decline in cellular function of aged mouse c-kit cardiac progenitor cells. / 01.10.2017 / PubMed / Full text
Association and interaction effects of Alzheimer's disease-associated genes and lifestyle on cognitive aging in older adults in a Taiwanese population. / 11.04.2017 / PubMed / Full text
Targeted sequencing of genome wide significant loci associated with bone mineral density (BMD) reveals significant novel and rare variants: the Cohorts for Heart and Aging Research in Genomic Epidemiology (CHARGE) targeted sequencing study. / 01.12.2016 / PubMed / Full text
Dynamic Phosphorylation of the Myocyte Enhancer Factor 2Cα1 Splice Variant Promotes Skeletal Muscle Regeneration and Hypertrophy. / 03.2017 / PubMed / Full text
Gene-based aggregate SNP associations between candidate AD genes and cognitive decline. / 04.2016 / PubMed / Full text
Postnatal expression patterns and polymorphism analysis of the bovine myocyte enhancer factor 2C (Mef2C) gene. / 12.2014 / PubMed / Full text

MME

Geriatric Opioid Harm Reduction: Interprofessional Student Learning Outcomes. / 01-12.2020 / PubMed / Full text
Effectiveness of local anesthetic injection in geriatric patients following operative management of proximal and diaphyseal femur fracture. / 11.2019 / PubMed / Full text
Membrane metallo-endopeptidase mediates cellular senescence induced by oncogenic PIK3CA accompanied with pro-tumorigenic secretome. / 01.08.2019 / PubMed / Full text
Medial meniscus extrusion increases with age and BMI and is depending on different loading conditions. / 08.2018 / PubMed / Full text
Rare Variants in MME, Encoding Metalloprotease Neprilysin, Are Linked to Late-Onset Autosomal-Dominant Axonal Polyneuropathies. / 01.09.2016 / PubMed / Full text
Genetic analysis of mesangial matrix expansion in aging mice and identification of Far2 as a candidate gene. / 12.2013 / PubMed / Full text

MVD

Young and elderly oral squamous cell carcinoma patients present similar angiogenic profile and predominance of M2 macrophages: Comparative immunohistochemical study. / 12.2019 / PubMed / Full text
Prostate cancer aggressiveness and age: Impact of p53, BCL-2 and microvessel density. / 12.2018 / PubMed / Full text
Assessing Microvascular Function in Humans from a Chronic Disease Perspective. / 12.2017 / PubMed / Full text
Changes in pro-inflammatory markers and leucine concentrations in response to Nordic Walking training combined with vitamin D supplementation in elderly women. / 08.2017 / PubMed / Full text
Diffusion-weighted multiparametric MRI for monitoring longitudinal changes of parameters in rabbit VX2 liver tumors. / 09.2016 / PubMed / Full text
[Expression of vascular endothelial growth factor and microvessel density in different brain regions in aged rats]. / 07.2014 / PubMed / Full text

NDUFB8

Older Adults with Physical Frailty and Sarcopenia Show Increased Levels of Circulating Small Extracellular Vesicles with a Specific Mitochondrial Signature. / 15.04.2020 / PubMed / Full text
Mitochondrial Signatures in Circulating Extracellular Vesicles of Older Adults with Parkinson's Disease: Results from the EXosomes in PArkiNson's Disease (EXPAND) Study. / 12.02.2020 / PubMed / Full text
Effect of Melatonin on Rat Heart Mitochondria in Acute Heart Failure in Aged Rats. / 23.05.2018 / PubMed / Full text
Maternal nutrient restriction in baboon programs later-life cellular growth and respiration of cultured skin fibroblasts: a potential model for the study of aging-programming interactions. / 06.2018 / PubMed / Full text
Resveratrol Protects SAMP8 Brain Under Metabolic Stress: Focus on Mitochondrial Function and Wnt Pathway. / 04.2017 / PubMed / Full text
Reduced levels of mitochondrial complex I subunit NDUFB8 and linked complex I III oxidoreductase activity in the TgCRND8 mouse model of Alzheimer's disease. / 2014 / PubMed / Full text

NF1

Conditional reprograming culture conditions facilitate growth of lower grade glioma models. / 01.12.2020 / PubMed / Full text
Circular RNA NF1-419 enhances autophagy to ameliorate senile dementia by binding Dynamin-1 and Adaptor protein 2 B1 in AD-like mice. / 20.12.2019 / PubMed / Full text
NF1 loss induces senescence during human melanocyte differentiation in an iPSC-based model. / 07.2015 / PubMed / Full text
TGF-β/NF1/Smad4-mediated suppression of ANT2 contributes to oxidative stress in cellular senescence. / 12.2014 / PubMed / Full text
Neuropsychological impairments in elderly Neurofibromatosis type 1 patients. / 04.2014 / PubMed / Full text
Long-term prognosis of patients with pediatric pheochromocytoma. / 02.2014 / PubMed / Full text

NOS3

Application of Oxidative Stress to a Tissue-Engineered Vascular Aging Model Induces Endothelial Cell Senescence and Activation. / 22.05.2020 / PubMed / Full text
Hypertension and longevity: role of genetic polymorphisms in renin-angiotensin-aldosterone system and endothelial nitric oxide synthase. / 05.2019 / PubMed / Full text
NOS3 Inhibition Confers Post-Ischemic Protection to Young and Aging White Matter Integrity by Conserving Mitochondrial Dynamics and Miro-2 Levels. / 11.07.2018 / PubMed / Full text
Vascular senescence and ageing: a role for the MEOX proteins in promoting endothelial dysfunction. / 10.2017 / PubMed / Full text
Fetal programming of blood pressure in a transgenic mouse model of altered intrauterine environment. / 01.12.2016 / PubMed / Full text
Common polymorphisms in nitric oxide synthase (NOS) genes influence quality of aging and longevity in humans. / 04.2013 / PubMed / Full text

NPR1

The NPR1-WRKY46-WRKY6 signaling cascade mediates probenazole/salicylic acid-elicited leaf senescence in Arabidopsis thaliana. / 03.12.2020 / PubMed / Full text
Loss of proton/calcium exchange 1 results in the activation of plant defense and accelerated senescence in Arabidopsis. / 07.2020 / PubMed / Full text
Some things get better with age: differences in salicylic acid accumulation and defense signaling in young and mature Arabidopsis. / 2014 / PubMed / Full text
Mitogen-activated protein kinase 6 regulates NPR1 gene expression and activation during leaf senescence induced by salicylic acid. / 12.2014 / PubMed / Full text
Autophagy deficiency leads to accumulation of ubiquitinated proteins, ER stress, and cell death in Arabidopsis. / 09.2014 / PubMed / Full text
A dissection of the effects of ethylene, H2O2 and high irradiance on antioxidants and several genes associated with stress and senescence in tobacco leaves. / 15.02.2014 / PubMed / Full text

NRK

[Molecular mechanisms of mycelium of Cordyceps sinensis ameliorating renal tubular epithelial cells aging induced by D-galactose via inhibiting autophagy-related AMPK/ULK1 signaling activation]. / 03.2019 / PubMed / Full text
Hyperoside attenuates renal aging and injury induced by D-galactose via inhibiting AMPK-ULK1 signaling-mediated autophagy. / 24.12.2018 / PubMed / Full text
Fascin2 regulates cisplatin-induced apoptosis in NRK-52E cells. / 15.01.2017 / PubMed / Full text
2,3,5,4'-Tetrahydroxystilbene-2-O-[i]β[/i]-D-glucoside Promotes Expression of the Longevity Gene Klotho. / 2016 / PubMed / Full text
A role for the age-dependent loss of α(E)-catenin in regulation of N-cadherin expression and cell migration. / 01.06.2014 / PubMed / Full text
Overexpression of MMP-7 Increases Collagen 1A2 in the Aging Kidney. / 10.2013 / PubMed / Full text

PAK1

1,2,3-Triazolyl ester of ketorolac (15K): Boosting both heat-endurance and lifespan of C. elegans by down-regulating PAK1 at nM levels. / 2018 / PubMed / Full text
From bench (laboratory) to bed (hospital/home): How to explore effective natural and synthetic PAK1-blockers/longevity-promoters for cancer therapy. / 15.12.2017 / PubMed / Full text
Effect of Okinawa Propolis on PAK1 Activity, Caenorhabditis elegans Longevity, Melanogenesis, and Growth of Cancer Cells. / 13.07.2016 / PubMed / Full text
Several herbal compounds in Okinawa plants directly inhibit the oncogenic/aging kinase PAK1. / 12.2014 / PubMed / Full text
Herbal therapeutics that block the oncogenic kinase PAK1: a practical approach towards PAK1-dependent diseases and longevity. / 05.2014 / PubMed / Full text
PAK1-deficiency/down-regulation reduces brood size, activates HSP16.2 gene and extends lifespan in Caenorhabditis elegans. / 02.2013 / PubMed / Full text

PGP

Age-associated changes of the intrinsic nervous system in relation with interstitial cells in the pre-weaning goat rumen. / 14.07.2019 / PubMed / Full text
Changes in the interstitial cells of Cajal and neuronal nitric oxide synthase positive neuronal cells with aging in the esophagus of F344 rats. / 2017 / PubMed / Full text
Change in the Interstitial Cells of Cajal and nNOS Positive Neuronal Cells with Aging in the Stomach of F344 Rats. / 2017 / PubMed / Full text
The matrikine N-acetylated proline-glycine-proline induces premature senescence of nucleus pulposus cells via CXCR1-dependent ROS accumulation and DNA damage and reinforces the destructive effect of these cells on homeostasis of intervertebral discs. / 01.2017 / PubMed / Full text
[CHANGES IN THE PANCREATIC ISLETS AND NERVOUS ELEMENTS IN RATS DURING AGING (AN IMMUNOHISTOCHEMICAL STUDY)]. / 2015 / PubMed
Associations between xerostomia, histopathological alterations, and autonomic innervation of labial salivary glands in men in late midlife. / 09.2014 / PubMed / Full text

POR

The Ventricular System Enlarges Abnormally in the Seventies, Earlier in Men, and First in the Frontal Horn: A Study Based on More Than 3,000 Scans. / 2019 / PubMed / Full text
Clinical findings associated with development of postoperative reflux and short-term survival after small intestinal surgery in geriatric and mature nongeriatric horses. / 07.2019 / PubMed / Full text
Effect of Age and Allele Variants of CYP3A5, CYP3A4, and POR Genes on the Pharmacokinetics of Cyclosporin A in Pediatric Renal Transplant Recipients From Serbia. / 12.2017 / PubMed / Full text
Phosphorylation of WHIRLY1 by CIPK14 Shifts Its Localization and Dual Functions in Arabidopsis. / 01.05.2017 / PubMed / Full text
Endometriosis has no negative impact on outcomes of in vitro fertilisation in women with poor ovarian response. / 09.2016 / PubMed / Full text
Short-term complications after colic surgery in geriatric versus mature non-geriatric horses. / 02.2015 / PubMed / Full text

POT1

Decreased expression of TERT and telomeric proteins as human ovaries age may cause telomere shortening. / 27.08.2020 / PubMed / Full text
MiR-185 targets POT1 to induce telomere dysfunction and cellular senescence. / 18.07.2020 / PubMed / Full text
Genome-wide Association Analysis in Humans Links Nucleotide Metabolism to Leukocyte Telomere Length. / 05.03.2020 / PubMed / Full text
Seryl tRNA synthetase cooperates with POT1 to regulate telomere length and cellular senescence. / 2019 / PubMed / Full text
A newly identified berberine derivative induces cancer cell senescence by stabilizing endogenous G-quadruplexes and sparking a DNA damage response at the telomere region. / 03.11.2015 / PubMed / Full text
Caenorhabditis elegans POT-1 and POT-2 repress telomere maintenance pathways. / 02.2013 / PubMed / Full text

PRC1

Biological functions of chromobox (CBX) proteins in stem cell self-renewal, lineage-commitment, cancer and development. / 24.09.2020 / PubMed / Full text
Timosaponin A-III inhibits oncogenic phenotype via regulation of PcG protein BMI1 in breast cancer cells. / 07.2018 / PubMed / Full text
Epigenetic factors Polycomb (Pc) and Suppressor of zeste (Su(z)2) negatively regulate longevity in Drosophila melanogaster. / 02.2018 / PubMed / Full text
The Polycomb Group Protein Pcgf1 Is Dispensable in Zebrafish but Involved in Early Growth and Aging. / 2016 / PubMed / Full text
CBX7 and miR-9 are part of an autoregulatory loop controlling p16(INK) (4a). / 12.2015 / PubMed / Full text
Mitogen-activated protein kinase signaling mediates phosphorylation of polycomb ortholog Cbx7. / 20.12.2013 / PubMed / Full text

PROC

Does midlife aging impact women's sleep duration, continuity, and timing?: A longitudinal analysis from the Study of Women's Health Across the Nation. / 15.04.2020 / PubMed / Full text
Effects of feeding frequency of an elevated plane of milk replacer and calf age on behavior, and glucose and insulin kinetics in male Holstein calves. / 07.2019 / PubMed / Full text
Age-related effects on markers of inflammation and cartilage metabolism in response to an intra-articular lipopolysaccharide challenge in horses. / 02.2017 / PubMed / Full text
Normative data for rotational chair stratified by age. / 02.2016 / PubMed / Full text
Day-to-Day Impact of Vaginal Aging questionnaire: a multidimensional measure of the impact of vaginal symptoms on functioning and well-being in postmenopausal women. / 02.2015 / PubMed / Full text
Growth and feed conversion efficiency of Dorper and Rambouillet lambs. / 10.2013 / PubMed / Full text

PTGS2

Candesartan Neuroprotection in Rat Primary Neurons Negatively Correlates with Aging and Senescence: a Transcriptomic Analysis. / 03.2020 / PubMed / Full text
Senescent thyrocytes and thyroid tumor cells induce M2-like macrophage polarization of human monocytes via a PGE2-dependent mechanism. / 21.05.2019 / PubMed / Full text
Analysis of molecular networks and targets mining of Chinese herbal medicines on anti-aging. / 28.12.2016 / PubMed / Full text
Coordinated gene expression of neuroinflammatory and cell signaling markers in dorsolateral prefrontal cortex during human brain development and aging. / 2014 / PubMed / Full text
Coordination of gene expression of arachidonic and docosahexaenoic acid cascade enzymes during human brain development and aging. / 2014 / PubMed / Full text
Nodes and biological processes identified on the basis of network analysis in the brain of the senescence accelerated mice as an Alzheimer's disease animal model. / 2013 / PubMed / Full text

PTX3

Aerobic Training Down-Regulates Pentraxin 3 and Pentraxin 3/Toll-Like Receptor 4 Ratio, Irrespective of Oxidative Stress Response, in Elderly Subjects. / 27.01.2020 / PubMed / Full text
Sex Differences in the Association Between Pentraxin 3 and Cognitive Decline: The Cardiovascular Health Study. / 13.07.2020 / PubMed / Full text
Changes in Proteomic Profiles are Related to Changes in BMI and Fat Distribution During 10 Years of Aging. / 01.2020 / PubMed / Full text
Inflammatory Long Pentraxin 3 is Associated with Leukocyte Telomere Length in Night-Shift Workers. / 2017 / PubMed / Full text
Age-dependent cellular reactions of the human immune system of humanized NOD scid gamma mice on LPS stimulus. / 04.2017 / PubMed / Full text
Elevated pentraxin 3 level at the early stage of exercise training is associated with reduction of arterial stiffness in middle-aged and older adults. / 09.2016 / PubMed / Full text

RB1

Expression of p16 in nodular fasciitis: an implication for self-limited and inflammatory nature of the lesion. / 2019 / PubMed / Full text
G protein-coupled receptor kinase 4-induced cellular senescence and its senescence-associated gene expression profiling. / 15.11.2017 / PubMed / Full text
Mesenchymal stromal cells having inactivated RB1 survive following low irradiation and accumulate damaged DNA: Hints for side effects following radiotherapy. / 02.2017 / PubMed / Full text
Suppression of RAD21 Induces Senescence of MDA-MB-231 Human Breast Cancer Cells Through RB1 Pathway Activation Via c-Myc Downregulation. / 06.2016 / PubMed / Full text
RB1-mediated cell-autonomous and host-dependent oncosuppressor mechanisms in radiation-induced osteosarcoma. / 01.01.2014 / PubMed / Full text
Drosophila Fip200 is an essential regulator of autophagy that attenuates both growth and aging. / 08.2013 / PubMed / Full text

RIG

Protective Effect of Klotho against Ischemic Brain Injury Is Associated with Inhibition of RIG-I/NF-κB Signaling. / 2017 / PubMed / Full text
Aging impairs both primary and secondary RIG-I signaling for interferon induction in human monocytes. / 12.12.2017 / PubMed / Full text
Random Item Generation Is Affected by Age. / 01.10.2016 / PubMed / Full text
Aging-related renal injury and inflammation are associated with downregulation of Klotho and induction of RIG-I/NF-κB signaling pathway in senescence-accelerated mice. / 02.2016 / PubMed / Full text
Global analyses revealed age-related alterations in innate immune responses after stimulation of pathogen recognition receptors. / 06.2015 / PubMed / Full text
Attenuation of respiratory syncytial virus-induced and RIG-I-dependent type I IFN responses in human neonates and very young children. / 01.02.2014 / PubMed / Full text

RIPK1

Casein kinase 1G2 suppresses necroptosis-promoted testis aging by inhibiting receptor-interacting kinase 3. / 18.11.2020 / PubMed / Full text
Crucial role of the terminal complement complex in chondrocyte death and hypertrophy after cartilage trauma. / 05.2020 / PubMed / Full text
RIP kinases as modulators of inflammation and immunity. / 09.2018 / PubMed / Full text
TBK1 Suppresses RIPK1-Driven Apoptosis and Inflammation during Development and in Aging. / 06.09.2018 / PubMed / Full text
Necroptosis increases with age and is reduced by dietary restriction. / 08.2018 / PubMed / Full text
RIPK1-RIPK3-MLKL-dependent necrosis promotes the aging of mouse male reproductive system. / 15.08.2017 / PubMed / Full text

S100A8

Protective role of mesenchymal stem cells and mesenchymal stem cell-derived exosomes in cigarette smoke-induced mitochondrial dysfunction in mice. / 15.12.2019 / PubMed / Full text
S100A8, which increases with age, induces cellular senescence-like changes in bovine oviduct epithelial cells. / 09.2019 / PubMed / Full text
Fetal articular cartilage regeneration versus adult fibrocartilaginous repair: secretome proteomics unravels molecular mechanisms in an ovine model. / 06.07.2018 / PubMed / Full text
Lung cellular senescence is independent of aging in a mouse model of COPD/emphysema. / 13.06.2018 / PubMed / Full text
Age-dependent changes in inflammation and extracellular matrix in bovine oviduct epithelial cells during the post-ovulatory phase. / 09.2016 / PubMed / Full text
A transcriptional roadmap to the senescence and differentiation of human oral keratinocytes. / 01.2015 / PubMed / Full text

SERPINE1

Cerebrovascular Senescence Is Associated With Tau Pathology in Alzheimer's Disease. / 2020 / PubMed / Full text
p53 and p53-related mediators PAI-1 and IGFBP-3 are downregulated in peripheral blood mononuclear cells of HIV-patients exposed to non-nucleoside reverse transcriptase inhibitors. / 06.2020 / PubMed / Full text
Elevated circulating HtrA4 in preeclampsia may alter endothelial expression of senescence genes. / 15.01.2020 / PubMed / Full text
Candesartan Neuroprotection in Rat Primary Neurons Negatively Correlates with Aging and Senescence: a Transcriptomic Analysis. / 03.2020 / PubMed / Full text
Human iPSC-derived MSCs (iMSCs) from aged individuals acquire a rejuvenation signature. / 18.03.2019 / PubMed / Full text
A null mutation in [i]SERPINE1[/i] protects against biological aging in humans. / 11.2017 / PubMed / Full text

SHH

Recent advances in SHH medulloblastoma progression: tumor suppressor mechanisms and the tumor microenvironment. / 2019 / PubMed / Full text
An Endogenous Anti-aging Factor, Sonic Hedgehog, Suppresses Endometrial Stem Cell Aging through SERPINB2. / 03.07.2019 / PubMed / Full text
Sonic hedgehog regulation of cavernous nerve regeneration and neurite formation in aged pelvic plexus. / 02.2019 / PubMed / Full text
Evasion of cell senescence in SHH medulloblastoma. / 17.08.2016 / PubMed / Full text
Expression and Role of Sonic Hedgehog in the Process of Fracture Healing with Aging. / 03-04.2016 / PubMed
The Subjective Health Horizon Questionnaire (SHH-Q): Assessing Future Time Perspectives for Facets of an Active Lifestyle. / 2016 / PubMed / Full text

SNAP25

The Biological Foundations of Sarcopenia: Established and Promising Markers. / 2019 / PubMed / Full text
Contribution of adenosine and ATP to the carotid body chemosensory activity in ageing. / 10.2019 / PubMed / Full text
Frontotemporal dysregulation of the SNARE protein interactome is associated with faster cognitive decline in old age. / 06.2018 / PubMed / Full text
NUPR1 maintains autolysosomal efflux by activating SNAP25 transcription in cancer cells. / 2018 / PubMed / Full text
Global hypoxia induced impairment in learning and spatial memory is associated with precocious hippocampal aging. / 09.2016 / PubMed / Full text
NOS1 and SNAP25 polymorphisms are associated with Attention-Deficit/Hyperactivity Disorder symptoms in adults but not in children. / 04.2016 / PubMed / Full text

SOST

Remodeling process in bone of aged rats in response to resistance training. / 01.09.2020 / PubMed / Full text
Low Serum Levels of DKK2 Predict Incident Low-Impact Fracture in Older Women. / 07.2019 / PubMed / Full text
Bone adaptation in response to treadmill exercise in young and adult mice. / 06.2018 / PubMed / Full text
WNT1-induced Secreted Protein-1 (WISP1), a Novel Regulator of Bone Turnover and Wnt Signaling. / 29.05.2015 / PubMed / Full text
Relative influence of heritability, environment and genetics on serum sclerostin. / 03.2014 / PubMed / Full text
Novel sandwich ELISAs for rat DMP1: age-related decrease of circulatory DMP1 levels in male rats. / 12.2013 / PubMed / Full text

SPR

Regulation of lifespan by neural excitation and REST. / 10.2019 / PubMed / Full text
How many geriatricians should, at minimum, be staffing health regions in Australia? / 03.2018 / PubMed / Full text
Mutation of C. elegans demethylase spr-5 extends transgenerational longevity. / 02.2016 / PubMed / Full text
REST and stress resistance in ageing and Alzheimer's disease. / 27.03.2014 / PubMed / Full text
H3K4 demethylase activities repress proliferative and postmitotic aging. / 04.2014 / PubMed / Full text
Increase in tetrahydrobiopterin concentration with aging in the cerebral cortex of the senescence-accelerated mouse prone 10 strain caused by abnormal regulation of tetrahydrobiopterin biosynthesis. / 10.2013 / PubMed / Full text

TBP

Identification of reference genes for RT-qPCR data normalisation in aging studies. / 27.09.2019 / PubMed / Full text
Trinucleotide repeat expansion of TATA-binding protein gene associated with Parkinson's disease: A Thai multicenter study. / 07.2016 / PubMed / Full text
CALHM1 Deletion in Mice Affects Glossopharyngeal Taste Responses, Food Intake, Body Weight, and Life Span. / 07.2015 / PubMed / Full text
Deactivation of TBP contributes to SCA17 pathogenesis. / 20.12.2014 / PubMed / Full text
Age-dependent decrease in chaperone activity impairs MANF expression, leading to Purkinje cell degeneration in inducible SCA17 mice. / 22.01.2014 / PubMed / Full text
[Age estimation using content of sjTREC in human peripheral blood]. / 08.2013 / PubMed

TCF7L2

A myelin-related transcriptomic profile is shared by Pitt-Hopkins syndrome models and human autism spectrum disorder. / 03.2020 / PubMed / Full text
The dynamic methylome of islets in health and disease. / 09.2019 / PubMed / Full text
Lifelong physical activity is associated with promoter hypomethylation of genes involved in metabolism, myogenesis, contractile properties and oxidative stress resistance in aged human skeletal muscle. / 01.03.2019 / PubMed / Full text
TCF7L1 promotes skin tumorigenesis independently of β-catenin through induction of LCN2. / 03.05.2017 / PubMed / Full text
[Frequency of some diseases and conditions in geriatric patients with coronary heart disease and various genotypes of transcription factor 7-like 2 protein]. / 2014 / PubMed
Aging and cardiovascular diseases: the role of gene-diet interactions. / 11.2014 / PubMed / Full text

TET1

DNA methylation instability by BRAF-mediated TET silencing and lifestyle-exposure divides colon cancer pathways. / 16.12.2019 / PubMed / Full text
Age-related Changes in the Global DNA Methylation Profile of Oligodendrocyte Progenitor Cells Derived from Rat Spinal Cords. / 02.2019 / PubMed / Full text
Epigenetic Co-Deregulation of EZH2/TET1 is a Senescence-Countering, Actionable Vulnerability in Triple-Negative Breast Cancer. / 2019 / PubMed / Full text
DNA Hydroxymethylation Levels Are Altered in Blood Cells From Down Syndrome Persons Enrolled in the MARK-AGE Project. / 09.05.2018 / PubMed / Full text
Methylglyoxal induces endoplasmic reticulum stress and DNA demethylation in the Keap1 promoter of human lens epithelial cells and age-related cataracts. / 07.2014 / PubMed / Full text
On your (methyl) mark, get TET1, go! / 01.08.2013 / PubMed / Full text

TLR3

Effects of aging and lifelong aerobic exercise on expression of innate immune components in human skeletal muscle. / 01.12.2020 / PubMed / Full text
The Upregulation of Toll-Like Receptor 3 via Autocrine IFN-β Signaling Drives the Senescence of Human Umbilical Cord Blood-Derived Mesenchymal Stem Cells Through JAK1. / 2019 / PubMed / Full text
Repetitive TLR3 activation in the lung induces skeletal muscle adaptations and cachexia. / 06.2018 / PubMed / Full text
Age-related changes and distribution of T cell markers (CD3 and CD4) and toll-like receptors(TLR2, TLR3,TLR4 and TLR7) in the duck lymphoid organs. / 07.2017 / PubMed / Full text
Effect of age on the pathogenesis of DHV-1 in Pekin ducks and on the innate immune responses of ducks to infection. / 05.2014 / PubMed / Full text
[What's new in dermatological research?]. / 12.2012 / PubMed / Full text

TPO

Megakaryocytes promote osteoclastogenesis in aging. / 07.07.2020 / PubMed / Full text
To reflect human autoimmune thyroiditis, thyroid peroxidase (not thyroglobulin) antibodies should be measured in female (not sex-independent) NOD.H2 mice. / 04.2019 / PubMed / Full text
Kras is Required for Adult Hematopoiesis. / 07.2016 / PubMed / Full text
Signal for Thrombosis with Eltrombopag and Romiplostim: A Disproportionality Analysis of Spontaneous Reports Within VigiBase®. / 12.2015 / PubMed / Full text
Effect of different photoinitiators and reducing agents on cure efficiency and color stability of resin-based composites using different LED wavelengths. / 12.2015 / PubMed / Full text
Complex reference value distributions and partitioned reference intervals across the pediatric age range for 14 specialized biochemical markers in the CALIPER cohort of healthy community children and adolescents. / 23.10.2015 / PubMed / Full text

TRPA1

Important regulatory function of transient receptor potential ankyrin 1 receptors in age-related learning and memory alterations of mice. / 10.2019 / PubMed / Full text
Aging of mouse intervertebral disc and association with back pain. / 06.2019 / PubMed / Full text
Congeneric variability in lifespan extension and onset of senescence suggest active regulation of aging in response to low temperature. / 12.2018 / PubMed / Full text
A comparative study on the therapeutic effect of TRPV1, TRPA1, and TRPM8 agonists on swallowing dysfunction associated with aging and neurological diseases. / 02.2018 / PubMed / Full text
A Caenorhabditis elegans Model Elucidates a Conserved Role for TRPA1-Nrf Signaling in Reactive α-Dicarbonyl Detoxification. / 21.11.2016 / PubMed / Full text
A genetic program promotes C. elegans longevity at cold temperatures via a thermosensitive TRP channel. / 14.02.2013 / PubMed / Full text

VIM

Establishment and characterization of a fibroblast cell line from postmortem skin of an adult Chinese muntjac (Muntiacus reevesi). / 02.2020 / PubMed / Full text
The effect of test modality on dynamic exercise biomarkers in children, adolescents, and young adults. / 07.2019 / PubMed / Full text
Centenarians Overexpress Pluripotency-Related Genes. / 16.08.2019 / PubMed / Full text
Bioinformatics analysis of proteomics profiles in senescent human primary proximal tubule epithelial cells. / 01.04.2016 / PubMed / Full text
Assessment of Age-Related Differences in Functional Capacity Using the Virtual Reality Functional Capacity Assessment Tool (VRFCAT). / 06.2015 / PubMed / Full text
Reactive stroma in the prostate during late life: The role of microvasculature and antiangiogenic therapy influences. / 10.2015 / PubMed / Full text

ABCG2

Contribution of senescence in human endometrial stromal cells during proliferative phase to embryo receptivity†. / 23.06.2020 / PubMed / Full text
ABCG2 rs2231142 variant in hyperuricemia is modified by SLC2A9 and SLC22A12 polymorphisms and cardiovascular risk factors in an elderly community-dwelling population. / 17.03.2020 / PubMed / Full text
Morphological and immunohistochemical characteristics of the equine corneal epithelium. / 11.2019 / PubMed / Full text
Proteomic Analysis of the Developmental Trajectory of Human Hepatic Membrane Transporter Proteins in the First Three Months of Life. / 07.2016 / PubMed / Full text
Gene specific epigenetic regulation of hepatic folate transport system is responsible for perturbed cellular folate status during aging and exogenous modulation. / 06.2016 / PubMed / Full text

ACOX1

Dietary methionine increased the lipid accumulation in juvenile tiger puffer Takifugu rubripes. / 04.2019 / PubMed / Full text
Peroxisomal Acyl-CoA Oxidase Type 1: Anti-Inflammatory and Anti-Aging Properties with a Special Emphasis on Studies with LPS and Argan Oil as a Model Transposable to Aging. / 2018 / PubMed / Full text
Novel PPARα agonist MHY553 alleviates hepatic steatosis by increasing fatty acid oxidation and decreasing inflammation during aging. / 11.07.2017 / PubMed / Full text
Extended Multiplexing of Tandem Mass Tags (TMT) Labeling Reveals Age and High Fat Diet Specific Proteome Changes in Mouse Epididymal Adipose Tissue. / 05.2017 / PubMed / Full text
Decreased liver peroxisomal β-oxidation accompanied by changes in brain fatty acid composition in aged rats. / 02.2014 / PubMed / Full text

AGTR1

Lead-Related Genetic Loci, Cumulative Lead Exposure and Incident Coronary Heart Disease: The Normative Aging Study. / 2016 / PubMed / Full text
Association of gene variants of the renin-angiotensin system with accelerated hippocampal volume loss and cognitive decline in old age. / 01.11.2014 / PubMed / Full text
Impact of the AGTR1 A1166C polymorphism on subcortical hyperintensities and cognition in healthy older adults. / 2014 / PubMed / Full text
Influence of the AGTR1 A1166C genotype on the progression of arterial stiffness: A 16-year longitudinal study. / 12.2013 / PubMed / Full text
Identification of RAS genotypes that modulate blood pressure change by outdoor temperature. / 06.2013 / PubMed / Full text

AIM2

Papilloma-pseudovirus eradicates intestinal tumours and triples the lifespan of Apc mice. / 11.04.2017 / PubMed / Full text
Reduced levels of cytosolic DNA sensor AIM2 are associated with impaired cytokine responses in healthy elderly. / 06.2016 / PubMed / Full text
Gene expression of inflammasome components in peripheral blood mononuclear cells (PBMC) of vascular patients increases with age. / 2015 / PubMed / Full text
Effects of aging in the expression of NOD-like receptors and inflammasome-related genes in oral mucosa. / 02.2016 / PubMed / Full text
DAMPs, ageing, and cancer: The 'DAMP Hypothesis'. / 11.2015 / PubMed / Full text

ARMS2

Benefits, Potential Harms, and Optimal Use of Nutritional Supplementation for Preventing Progression of Age-Related Macular Degeneration. / 03.2017 / PubMed / Full text
A Phenotyping Regimen for Genetically Modified Mice Used to Study Genes Implicated in Human Diseases of Aging. / 14.07.2016 / PubMed / Full text
Mesopic Pelli-Robson contrast sensitivity and MP-1 microperimetry in healthy ageing and age-related macular degeneration. / 12.2016 / PubMed / Full text
[Age-related Macular Degeneration in the Japanese]. / 03.2016 / PubMed
Prevalence and Genetic Characteristics of Geographic Atrophy among Elderly Japanese with Age-Related Macular Degeneration. / 2016 / PubMed / Full text

BAD

I imidazoline receptor modulation protects aged SAMP8 mice against cognitive decline by suppressing the calcineurin pathway. / 31.10.2020 / PubMed / Full text
Xanthohumol exerts protective effects in liver alterations associated with aging. / 03.2019 / PubMed / Full text
Protective effect of xanthohumol against age-related brain damage. / 11.2017 / PubMed / Full text
Melatonin decreases the expression of inflammation and apoptosis markers in the lung of a senescence-accelerated mice model. / 03.2016 / PubMed / Full text
Melatonin Counteracts at a Transcriptional Level the Inflammatory and Apoptotic Response Secondary to Ischemic Brain Injury Induced by Middle Cerebral Artery Blockade in Aging Rats. / 2015 / PubMed / Full text

BMPR2

Human placenta-derived mesenchymal stem cells stimulate ovarian function via miR-145 and bone morphogenetic protein signaling in aged rats. / 05.11.2020 / PubMed / Full text
Centenarians Overexpress Pluripotency-Related Genes. / 16.08.2019 / PubMed / Full text
Age-related expression of TGF beta family receptors in human cumulus oophorus cells. / 09.2017 / PubMed / Full text
Selective enhancement of endothelial BMPR-II with BMP9 reverses pulmonary arterial hypertension. / 07.2015 / PubMed / Full text
Update on pediatric pulmonary arterial hypertension. Differences and similarities to adult disease. / 2013 / PubMed / Full text

BPI

High TARC plasma levels confer protection to long living individuals by inducing M2 profile. / 01.2021 / PubMed / Full text
Circulating BPIFB4 Levels Associate With and Influence the Abundance of Reparative Monocytes and Macrophages in Long Living Individuals. / 2020 / PubMed / Full text
The effect of postural deformities on back function and pain in patients with Parkinson's disease. / 2019 / PubMed / Full text
The expression of the BPIFB4 and CXCR4 associates with sustained health in long-living individuals from Cilento-Italy. / 22.01.2017 / PubMed / Full text
Age-dependent expression of the BPI gene in Sutai piglets. / 28.06.2013 / PubMed / Full text

CCL3

Assessment of neuroinflammation in the aging hippocampus using large-molecule microdialysis: Sex differences and role of purinergic receptors. / 07.11.2020 / PubMed / Full text
Microglial translational profiling reveals a convergent APOE pathway from aging, amyloid, and tau. / 03.09.2018 / PubMed / Full text
Time-Dependent Changes in Local and Serum Levels of Inflammatory Cytokines as Markers for Incised Wound Aging of Skeletal Muscles. / 05.2018 / PubMed / Full text
Age-related pro-inflammatory and pro-angiogenic changes in human aqueous humor. / 2018 / PubMed / Full text
Changes in the expression of the Toll-like receptor system in the aging rat kidneys. / 2014 / PubMed / Full text

CCNB1

The antioxidant icariin protects porcine oocytes from age-related damage in vitro. / 12.05.2020 / PubMed / Full text
Antioxidant hesperetin improves the quality of porcine oocytes during aging in vitro. / 01.2019 / PubMed / Full text
Effect of CCNB1 silencing on cell cycle, senescence, and apoptosis through the p53 signaling pathway in pancreatic cancer. / 01.2018 / PubMed / Full text
Hypoxia Upregulates Mitotic Cyclins Which Contribute to the Multipotency of Human Mesenchymal Stem Cells by Expanding Proliferation Lifespan. / 31.03.2018 / PubMed / Full text
Age-specific gene expression signatures for breast tumors and cross-species conserved potential cancer progression markers in young women. / 2013 / PubMed / Full text

CCND1

Effects of hydrogen peroxide, doxorubicin and ultraviolet irradiation on senescence of human dental pulp stem cells. / 09.2020 / PubMed / Full text
Candesartan Neuroprotection in Rat Primary Neurons Negatively Correlates with Aging and Senescence: a Transcriptomic Analysis. / 03.2020 / PubMed / Full text
Expansion of adipose tissue-derived stromal cells at "physiologic" hypoxia attenuates replicative senescence. / 06.2017 / PubMed / Full text
Sporadic colorectal cancer development shows rejuvenescence regarding epithelial proliferation and apoptosis. / 2013 / PubMed / Full text
Expression profiling of cell cycle genes in human pancreatic islets with and without type 2 diabetes. / 15.08.2013 / PubMed / Full text

CD22

Sialylation and Galectin-3 in Microglia-Mediated Neuroinflammation and Neurodegeneration. / 2020 / PubMed / Full text
CD22 blockade restores homeostatic microglial phagocytosis in ageing brains. / 04.2019 / PubMed / Full text
Age-related changes in mRNA expression of selected surface receptors in lymphocytes of dairy calves. / 03.2018 / PubMed / Full text
Siglec-G Deficiency Leads to Autoimmunity in Aging C57BL/6 Mice. / 01.07.2015 / PubMed / Full text
Double negative (CD19 IgG IgD-CD27-) B lymphocytes: a new insight from telomerase in healthy elderly, in centenarian offspring and in Alzheimer's disease patients. / 11.2014 / PubMed / Full text

CD2AP

Recent studies on cellular and molecular mechanisms in Alzheimer's disease: focus on epigenetic factors and histone deacetylase. / 28.03.2018 / PubMed / Full text
Association and interaction effects of Alzheimer's disease-associated genes and lifestyle on cognitive aging in older adults in a Taiwanese population. / 11.04.2017 / PubMed / Full text
Gene-based aggregate SNP associations between candidate AD genes and cognitive decline. / 04.2016 / PubMed / Full text
HYDRA: Revealing heterogeneity of imaging and genetic patterns through a multiple max-margin discriminative analysis framework. / 15.01.2017 / PubMed / Full text
Dendrin ablation prolongs life span by delaying kidney failure. / 08.2015 / PubMed / Full text

CD81

Ovarian aging increases small extracellular vesicle CD81 release in human follicular fluid and influences miRNA profiles. / 17.06.2020 / PubMed / Full text
Older Adults with Physical Frailty and Sarcopenia Show Increased Levels of Circulating Small Extracellular Vesicles with a Specific Mitochondrial Signature. / 15.04.2020 / PubMed / Full text
Increased production of functional small extracellular vesicles in senescent endothelial cells. / 04.2020 / PubMed / Full text
Mitochondrial Signatures in Circulating Extracellular Vesicles of Older Adults with Parkinson's Disease: Results from the EXosomes in PArkiNson's Disease (EXPAND) Study. / 12.02.2020 / PubMed / Full text
Extracellular Vesicles Derived from Senescent Fibroblasts Attenuate the Dermal Effect on Keratinocyte Differentiation. / 04.02.2020 / PubMed / Full text

CES1

[Comparative Study of Hydrolase Activity in Skin with Liver and Intestine, and Its Aging Relation of Carboxylesterase Expression in Cynomolgus Monkey and Beagle Dog]. / 2019 / PubMed / Full text
Age-Dependent Absolute Abundance of Hepatic Carboxylesterases (CES1 and CES2) by LC-MS/MS Proteomics: Application to PBPK Modeling of Oseltamivir In Vivo Pharmacokinetics in Infants. / 02.2017 / PubMed / Full text
Identifying clinically relevant sources of variability: The clopidogrel challenge. / 02.2017 / PubMed / Full text
Age-Dependent Human Hepatic Carboxylesterase 1 (CES1) and Carboxylesterase 2 (CES2) Postnatal Ontogeny. / 07.2016 / PubMed / Full text
Distinct patterns of aging effects on the expression and activity of carboxylesterases in rat liver and intestine. / 02.2014 / PubMed / Full text

CFB

Effect of Age on the Efficacy and Safety of Once-Daily Single-Inhaler Triple Therapy Fluticasone Furoate/Umeclidinium/Vilanterol in Patients With Chronic Obstructive Pulmonary Disease: A Post Hoc Analysis of the IMPACT Trial. / 05.10.2020 / PubMed / Full text
The expression of C1 inhibitor (C1INH) in macrophages is upregulated by retinal pigment epithelial cells - implication in subretinal immune privilege in the aging eye. / 13.06.2018 / PubMed / Full text
Extended Multiplexing of Tandem Mass Tags (TMT) Labeling Reveals Age and High Fat Diet Specific Proteome Changes in Mouse Epididymal Adipose Tissue. / 05.2017 / PubMed / Full text
Genetic factors associated with the development of age-related macular degeneration. / 2016 / PubMed / Full text
Gene expression changes in aging retinal microglia: relationship to microglial support functions and regulation of activation. / 10.2013 / PubMed / Full text

CLN3

SIRT6 histone deacetylase functions as a potential oncogene in human melanoma. / 09.2017 / PubMed / Full text
Age-dependent alterations in neuronal activity in the hippocampus and visual cortex in a mouse model of Juvenile Neuronal Ceroid Lipofuscinosis (CLN3). / 04.2017 / PubMed / Full text
Photoreceptor phagosome processing defects and disturbed autophagy in retinal pigment epithelium of Cln3Δex1-6 mice modelling juvenile neuronal ceroid lipofuscinosis (Batten disease). / 15.12.2015 / PubMed / Full text
Finding the most appropriate mouse model of juvenile CLN3 (Batten) disease for therapeutic studies: the importance of genetic background and gender. / 04.2015 / PubMed / Full text
Xbp1 directs global repression of budding yeast transcription during the transition to quiescence and is important for the longevity and reversibility of the quiescent state. / 10.2013 / PubMed / Full text

CXCR1

Harmful neutrophil subsets in patients with ischemic stroke: Association with disease severity. / 07.2019 / PubMed / Full text
Knockdown of IL-8 Provoked Premature Senescence of Placenta-Derived Mesenchymal Stem Cells. / 15.06.2017 / PubMed / Full text
The matrikine N-acetylated proline-glycine-proline induces premature senescence of nucleus pulposus cells via CXCR1-dependent ROS accumulation and DNA damage and reinforces the destructive effect of these cells on homeostasis of intervertebral discs. / 01.2017 / PubMed / Full text
Habitual physical activity is associated with the maintenance of neutrophil migratory dynamics in healthy older adults. / 08.2016 / PubMed / Full text
Activation profile of CXCL8-stimulated neutrophils and aging. / 03.2013 / PubMed / Full text

DKC1

CD8 T-cell senescence and skewed lymphocyte subsets in young Dyskeratosis Congenita patients with PARN and DKC1 mutations. / 09.2020 / PubMed / Full text
Successful liver transplantation in short telomere syndromes without bone marrow failure due to DKC1 mutation. / 05.2020 / PubMed / Full text
Acute telomerase components depletion triggers oxidative stress as an early event previous to telomeric shortening. / 04.2018 / PubMed / Full text
Cinnamaldehyde and eugenol change the expression folds of AKT1 and DKC1 genes and decrease the telomere length of human adipose-derived stem cells (hASCs): An experimental and in silico study. / 03.2017 / PubMed / Full text
Molecular adaptation of telomere associated genes in mammals. / 15.11.2013 / PubMed / Full text

DMP1

GREM1 inhibits osteogenic differentiation, senescence and BMP transcription of adipose-derived stem cells. / 09.03.2020 / PubMed / Full text
Cx43 overexpression in osteocytes prevents osteocyte apoptosis and preserves cortical bone quality in aging mice. / 07.2018 / PubMed / Full text
[i]Dmp1[/i] Null Mice Develop a Unique Osteoarthritis-like Phenotype. / 2016 / PubMed / Full text
Decline in calcitonin receptor expression in osteocytes with age. / 05.2014 / PubMed / Full text
Novel sandwich ELISAs for rat DMP1: age-related decrease of circulatory DMP1 levels in male rats. / 12.2013 / PubMed / Full text

DRD4

ADHD risk genes involved in dopamine signaling and metabolism are associated with reduced estimated life expectancy at young adult follow-up in hyperactive and control children. / 04.2019 / PubMed / Full text
Age-dependent role of pre- and perinatal factors in interaction with genes on ADHD symptoms across adolescence. / 07.2017 / PubMed / Full text
Association between dopamine D4 receptor polymorphism and age related changes in brain glucose metabolism. / 2013 / PubMed / Full text
Polymorphic variants of neurotransmitter receptor genes may affect sexual function in aging males: data from the HALS study. / 2013 / PubMed / Full text
DRD4 genotype predicts longevity in mouse and human. / 02.01.2013 / PubMed / Full text

DST

Ancestral germen/soma distinction in microbes: Expanding the disposable soma theory of aging to all unicellular lineages. / 07.2020 / PubMed / Full text
Diet Quality Is Associated With Mortality in Adults Aged 80 Years and Older: A Prospective Study. / 10.2019 / PubMed / Full text
The associations between diet quality, Body Mass Index (BMI) and Health and Activity Limitation Index (HALex) in the Geisinger Rural Aging Study (GRAS). / 2014 / PubMed / Full text
Depression-like behavior is dependent on age in male SAMP8 mice. / 04.2013 / PubMed / Full text
Swallowing disorders in nursing home residents: how can the problem be explained? / 2013 / PubMed / Full text

E2F3

Time-course transcriptome analysis of medullary thymic epithelial cells in the early phase of thymic involution. / 07.2018 / PubMed / Full text
miR-34a promotes fibrosis in aged lungs by inducing alveolarepithelial dysfunctions. / 01.03.2017 / PubMed / Full text
Global transcriptional profiling reveals distinct functions of thymic stromal subsets and age-related changes during thymic involution. / 09.10.2014 / PubMed / Full text
Tumor-suppressive microRNA-449a induces growth arrest and senescence by targeting E2F3 in human lung cancer cells. / 28.03.2014 / PubMed / Full text
Elevated miR-34c-5p mediates dermal fibroblast senescence by ultraviolet irradiation. / 2013 / PubMed / Full text

ERAS

Enhanced Recovery After Surgery: Are the Principles Applicable to Adult and Geriatric Acute Care and Trauma Surgery? / 03.2019 / PubMed / Full text
Prospective application of an implementation framework to improve postoperative nutrition care processes: Evaluation of a mixed methods implementation study. / 09.2018 / PubMed / Full text
Enhanced Recovery After Surgery (ERAS) - The Evidence in Geriatric Emergency Surgery: A Systematic Review. / Sept-10.2017 / PubMed / Full text
Multimodal Rehabilitation in Geriatric Emergency Surgery. / Sept-10.2017 / PubMed / Full text
Surgical Stress Reduction in Elderly Patients Undergoing Elective Colorectal Laparoscopic Surgery within an ERAS Protocol. / 11-12.2016 / PubMed / Full text

FBL

APPLICATION OF A NOVEL QUANTITATIVE TRACTOGRAPHY-BASED ANALYSIS OF DIFFUSION TENSOR IMAGING TO EXAMINE FIBER BUNDLE LENGTH IN HUMAN CEREBRAL WHITE MATTER. / 04.2016 / PubMed / Full text
Cognitive reserve moderates the relationship between neuropsychological performance and white matter fiber bundle length in healthy older adults. / 06.2017 / PubMed / Full text
Fiber bundle length and cognition: a length-based tractography MRI study. / 12.2015 / PubMed / Full text
White matter changes with age utilizing quantitative diffusion MRI. / 15.07.2014 / PubMed / Full text
Impact of body mass index on neuronal fiber bundle lengths among healthy older adults. / 09.2013 / PubMed / Full text

FGA

Goal Pursuit, Goal Adjustment, and Pain in Middle-Aged Adults Aging With Physical Disability. / 12.2019 / PubMed / Full text
Tenacious Goal Pursuit, Flexible Goal Adjustment, and Life Satisfaction Among Chinese Older Adult Couples. / 01.2020 / PubMed / Full text
Association of tenacious goal pursuit and flexible goal adjustment with out-of-home mobility among community-dwelling older people. / 09.2019 / PubMed / Full text
Assimilative and accommodative coping in older adults with and without sensory impairment: four-year change and prospective relations with affective well-being. / 09.2019 / PubMed / Full text
Age stereotypes, flexible goal adjustment, and well-being among Chinese older adults. / 02.2018 / PubMed / Full text

FOXA1

Analyses of an epigenetic switch involved in the activation of pioneer factor FOXA1 leading to the prognostic value of estrogen receptor and FOXA1 co-expression in breast cancer. / 28.09.2019 / PubMed / Full text
The correlation of copy number variations with longevity in a genome-wide association study of Han Chinese. / 05.06.2018 / PubMed / Full text
FOXA1 and SOX9 Expression in the Developing Urogenital Sinus of the Tammar Wallaby (Macropus eugenii). / 2015 / PubMed / Full text
Epigenetic mechanisms of peptidergic regulation of gene expression during aging of human cells. / 03.2015 / PubMed / Full text
Association of levels of fasting glucose and insulin with rare variants at the chromosome 11p11.2-MADD locus: Cohorts for Heart and Aging Research in Genomic Epidemiology (CHARGE) Consortium Targeted Sequencing Study. / 06.2014 / PubMed / Full text

FOXN1

Thymic rejuvenation via FOXN1-reprogrammed embryonic fibroblasts (FREFs) to counteract age-related inflammation. / 17.09.2020 / PubMed / Full text
Role of Bone Marrow Maturity, Insulin-Like Growth Factor 1 Receptor, and Forkhead Box Protein N1 in Thymic Involution and Rejuvenation. / 10.2016 / PubMed / Full text
Foxn1 Is Dynamically Regulated in Thymic Epithelial Cells during Embryogenesis and at the Onset of Thymic Involution. / 2016 / PubMed / Full text
A deletion in FOXN1 is associated with a syndrome characterized by congenital hypotrichosis and short life expectancy in Birman cats. / 2015 / PubMed / Full text
Regeneration of the aged thymus by a single transcription factor. / 04.2014 / PubMed / Full text

FOXO6

Novel molecular mechanisms for the adaptogenic effects of herbal extracts on isolated brain cells using systems biology. / 15.11.2018 / PubMed / Full text
Introduction to FOXO Biology. / 2019 / PubMed / Full text
FOXO in Neural Cells and Diseases of the Nervous System. / 2018 / PubMed / Full text
FOXO Transcriptional Factors and Long-Term Living. / 2017 / PubMed / Full text
Long live FOXO: unraveling the role of FOXO proteins in aging and longevity. / 04.2016 / PubMed / Full text

GDF9

Prediction of ovarian aging using ovarian expression of BMP15, GDF9, and C-KIT. / 04.2020 / PubMed / Full text
Single xenotransplant of rat brown adipose tissue prolonged the ovarian lifespan of aging mice by improving follicle survival. / 12.2019 / PubMed / Full text
Observation of the influences of diosgenin on aging ovarian reserve and function in a mouse model. / 18.10.2017 / PubMed / Full text
Effects of aging on gene expression and mitochondrial DNA in the equine oocyte and follicle cells. / 07.2015 / PubMed / Full text
Identification of a mutation in GDF9 as a novel cause of diminished ovarian reserve in young women. / 09.2013 / PubMed / Full text

GGCT

Blockade of γ-Glutamylcyclotransferase Enhances Docetaxel Growth Inhibition of Prostate Cancer Cells. / 09.2019 / PubMed / Full text
Mechanisms of Tumor Growth Inhibition by Depletion of γ-Glutamylcyclotransferase (GGCT): A Novel Molecular Target for Anticancer Therapy. / 14.07.2018 / PubMed / Full text
Depletion of gamma-glutamylcyclotransferase in cancer cells induces autophagy followed by cellular senescence. / 2018 / PubMed / Full text
Prohibitin-2 is a novel regulator of p21 induced by depletion of γ-glutamylcyclotransferase. / 29.01.2018 / PubMed / Full text
Depletion of γ-glutamylcyclotransferase inhibits breast cancer cell growth via cellular senescence induction mediated by CDK inhibitor upregulation. / 22.09.2016 / PubMed / Full text

GIT2

The RXFP3 receptor is functionally associated with cellular responses to oxidative stress and DNA damage. / 03.12.2019 / PubMed / Full text
Multidimensional informatic deconvolution defines gender-specific roles of hypothalamic GIT2 in aging trajectories. / 12.2019 / PubMed / Full text
GIT2-A keystone in ageing and age-related disease. / 05.2018 / PubMed / Full text
Genomic deletion of GIT2 induces a premature age-related thymic dysfunction and systemic immune system disruption. / 04.03.2017 / PubMed / Full text
GIT2 Acts as a Systems-Level Coordinator of Neurometabolic Activity and Pathophysiological Aging. / 2015 / PubMed / Full text

GPX4

l-carnitine supplementation during in vitro culture regulates oxidative stress in embryos from bovine aged oocytes. / 02.2020 / PubMed / Full text
Dietary Selenium Supplementation Ameliorates Female Reproductive Efficiency in Aging Mice. / 11.12.2019 / PubMed / Full text
Resveratrol improves in vitro maturation of oocytes in aged mice and humans. / 05.2018 / PubMed / Full text
Differential menopause- versus aging-induced changes in oxidative stress and circadian rhythm gene markers. / 06.2017 / PubMed / Full text
Maternal obesity in the rat impairs male offspring aging of the testicular antioxidant defence system. / 09.2017 / PubMed / Full text

GRK2

G protein-coupled receptor kinase 2 modifies the ability of Caenorhabditis elegans to survive oxidative stress. / 16.10.2020 / PubMed / Full text
G protein coupled receptor kinases modulate Caenorhabditis elegans reactions to heat stresses. / 01.10.2020 / PubMed / Full text
Loss of dynamic regulation of G protein-coupled receptor kinase 2 by nitric oxide leads to cardiovascular dysfunction with aging. / 01.05.2020 / PubMed / Full text
Senescent Cells Differentially Translate Senescence-Related mRNAs Via Ribosome Heterogeneity. / 18.06.2019 / PubMed / Full text
Effects of exercise training on cardiovascular adrenergic system. / 28.11.2013 / PubMed / Full text

HAS2

Sodium tanshinone IIA sulfonate restrains fibrogenesis through induction of senescence in mice with induced deep endometriosis. / 09.2020 / PubMed / Full text
Age-related changes in cyclic phosphatidic acid-induced hyaluronic acid synthesis in human fibroblasts. / 01.2018 / PubMed / Full text
Microvasculature of the Mouse Cerebral Cortex Exhibits Increased Accumulation and Synthesis of Hyaluronan With Aging. / 01.06.2017 / PubMed / Full text
Hyaluronan synthase 2 regulates fibroblast senescence in pulmonary fibrosis. / 09.2016 / PubMed / Full text
Age-associated changes in gene expression of goat oocytes. / 01.09.2013 / PubMed / Full text

HCN2

Protein expression changes of HCN1 and HCN2 in hippocampal subregions of gerbils during the normal aging process. / 11.2019 / PubMed / Full text
Characteristics of hyperpolarization-activated cyclic nucleotide-gated channels in dorsal root ganglion neurons at different ages and sizes. / 11.11.2015 / PubMed / Full text
Age-associated expression of HCN channel isoforms in rat sinoatrial node. / 02.2016 / PubMed / Full text
Altered expression of hyperpolarization-activated cyclic nucleotide-gated channels and microRNA-1 and -133 in patients with age-associated atrial fibrillation. / 09.2015 / PubMed / Full text
Differential expression of hyperpolarization-activated cyclic nucleotide-gated channel subunits during hippocampal development in the mouse. / 27.02.2015 / PubMed / Full text

HSPA8

Alcohol drinking exacerbates neural and behavioral pathology in the 3xTg-AD mouse model of Alzheimer's disease. / 2019 / PubMed / Full text
Influence of Normal Aging on Brain Autophagy: A Complex Scenario. / 2019 / PubMed / Full text
Nitric oxide contributes to protein homeostasis by S-nitrosylations of the chaperone HSPA8 and the ubiquitin ligase UBE2D. / 01.2019 / PubMed / Full text
Cerebrospinal Fluid Concentration of Key Autophagy Protein Lamp2 Changes Little During Normal Aging. / 2018 / PubMed / Full text
Age-Related Decrease in Heat Shock 70-kDa Protein 8 in Cerebrospinal Fluid Is Associated with Increased Oxidative Stress. / 2016 / PubMed / Full text

IDH1

Oxidative Damage to the TCA Cycle Enzyme MDH1 Dysregulates Bioenergetic Enzymatic Activity in the Aged Murine Brain. / 03.04.2020 / PubMed / Full text
An integrated metabolomic and gene expression analysis identifies heat and calcium metabolic networks underlying postharvest sweet cherry fruit senescence. / 12.2019 / PubMed / Full text
GBM-associated mutations and altered protein expression are more common in young patients. / 25.10.2016 / PubMed / Full text
IDH1 Associated with Neuronal Apoptosis in Adult Rats Brain Following Intracerebral Hemorrhage. / 07.2017 / PubMed / Full text
2-Hydroxyglutarate Inhibits ATP Synthase and mTOR Signaling. / 01.09.2015 / PubMed / Full text

IRS2

Effects of Heshouwuyin on gene expression of the insulin/IGF signalling pathway in rat testis and spermatogenic cells. / 12.2020 / PubMed / Full text
Involvement of insulin receptor substrates in cognitive impairment and Alzheimer's disease. / 08.2019 / PubMed / Full text
The senescent status of endothelial cells affects proliferation, inflammatory profile and SOX2 expression in bone marrow-derived mesenchymal stem cells. / 06.2019 / PubMed / Full text
Therapeutic and preventive effects of exercise on cardiometabolic parameters in aging and obese rats. / 02.2019 / PubMed / Full text
Analysis of MTNR1B gene polymorphisms in relationship with IRS2 gene variants, epicardial fat thickness, glucose homeostasis and cognitive performance in the elderly. / 2017 / PubMed / Full text

KCNB1

Oxidation of KCNB1 potassium channels in the murine brain during aging is associated with cognitive impairment. / 14.05.2019 / PubMed / Full text
Oxidation of KCNB1 Potassium Channels Causes Neurotoxicity and Cognitive Impairment in a Mouse Model of Traumatic Brain Injury. / 26.10.2016 / PubMed / Full text
Oxidation of K( ) Channels in Aging and Neurodegeneration. / 03.2016 / PubMed / Full text
Oxidation of KCNB1 K( ) channels in central nervous system and beyond. / 26.05.2014 / PubMed / Full text
Molecular mechanisms underlying the apoptotic effect of KCNB1 K channel oxidation. / 08.02.2013 / PubMed / Full text

KISS1

In silico analysis of human renin gene-gene interactions and neighborhood topologically associated domains suggests breakdown of insulators contribute to ageing-associated diseases. / 12.2019 / PubMed / Full text
Kisspeptin level in the aging ovary is regulated by the sympathetic nervous system. / 01.2017 / PubMed / Full text
Kisspeptin across the human lifespan:evidence from animal studies and beyond. / 06.2016 / PubMed / Full text
Effects of Age and Estradiol on Gene Expression in the Rhesus Macaque Hypothalamus. / 2015 / PubMed / Full text
[Profiles of reproduction-related mRNA expressions in hypothalamus of female mice with advancing age]. / 17.12.2013 / PubMed

LIF

Use of the Reversible Myogenic to Lipogenic Transdifferentiation Switch for the Design of Pre-clinical Drug Screening in Idiopathic Pulmonary Fibrosis. / 2020 / PubMed / Full text
Aminopeptidase N expression in the endometrium could affect endometrial receptivity. / 25.06.2019 / PubMed / Full text
Efficacy of leukemia inhibitory factor as a therapeutic for permanent large vessel stroke differs among aged male and female rats. / 15.03.2019 / PubMed / Full text
Assaying human neutrophil elastase activity by capillary zone electrophoresis combined with laser-induced fluorescence. / 06.11.2015 / PubMed / Full text
iPSCs, aging and age-related diseases. / 25.09.2014 / PubMed / Full text

LONP1

Improved mitochondrial stress response in long-lived Snell dwarf mice. / 12.2019 / PubMed / Full text
Mitochondria organize the cellular proteostatic response and promote cellular senescence. / 15.03.2019 / PubMed / Full text
A mitochondrial FUNDC1/HSC70 interaction organizes the proteostatic stress response at the risk of cell morbidity. / 01.02.2019 / PubMed / Full text
Mitochondrial Lon protease in human disease and aging: Including an etiologic classification of Lon-related diseases and disorders. / 11.2016 / PubMed / Full text
Lon protease: A key enzyme controlling mitochondrial bioenergetics in cancer. / 10-12.2014 / PubMed / Full text

MAPK14

Candesartan Neuroprotection in Rat Primary Neurons Negatively Correlates with Aging and Senescence: a Transcriptomic Analysis. / 03.2020 / PubMed / Full text
Chlorella vulgaris modulates the expression of senescence-associated genes in replicative senescence of human diploid fibroblasts. / 01.2020 / PubMed / Full text
Micro-RNAS Regulate Metabolic Syndrome-induced Senescence in Porcine Adipose Tissue-derived Mesenchymal Stem Cells through the P16/MAPK Pathway. / 10.2018 / PubMed / Full text
G protein-coupled receptor kinase 4-induced cellular senescence and its senescence-associated gene expression profiling. / 15.11.2017 / PubMed / Full text
Targeting genes in insulin-associated signalling pathway, DNA damage, cell proliferation and cell differentiation pathways by tocotrienol-rich fraction in preventing cellular senescence of human diploid fibroblasts. / 11-12.2015 / PubMed / Full text

MARCKS

Ser46-Phosphorylated MARCKS Is a Marker of Neurite Degeneration at the Pre-aggregation Stage in PD/DLB Pathology. / 07-08.2018 / PubMed / Full text
MARCKS contributes to stromal cancer-associated fibroblast activation and facilitates ovarian cancer metastasis. / 21.06.2016 / PubMed / Full text
MARCKS-dependent mucin clearance and lipid metabolism in ependymal cells are required for maintenance of forebrain homeostasis during aging. / 10.2015 / PubMed / Full text
The novel protein kinase C epsilon isoform at the adult neuromuscular synapse: location, regulation by synaptic activity-dependent muscle contraction through TrkB signaling and coupling to ACh release. / 10.02.2015 / PubMed / Full text
Low hippocampal PI(4,5)P₂ contributes to reduced cognition in old mice as a result of loss of MARCKS. / 04.2013 / PubMed / Full text

MGP

Circulating Vitamin K Is Inversely Associated with Incident Cardiovascular Disease Risk among Those Treated for Hypertension in the Health, Aging, and Body Composition Study (Health ABC). / 05.2017 / PubMed / Full text
Aging related methylation influences the gene expression of key control genes in colorectal cancer and adenoma. / 21.12.2016 / PubMed / Full text
[Bone metabolism and cardiovascular function update. Cross link of hypertension, bone loss and vascular calcification - common back grounds in renin angiotensin system with anti-aging aspect -]. / 07.2014 / PubMed / Full text
Circulating uncarboxylated matrix Gla protein, a marker of vitamin K status, as a risk factor of cardiovascular disease. / 02.2014 / PubMed / Full text
Elastin haploinsufficiency impedes the progression of arterial calcification in MGP-deficient mice. / 02.2014 / PubMed / Full text

MLKL

Casein kinase 1G2 suppresses necroptosis-promoted testis aging by inhibiting receptor-interacting kinase 3. / 18.11.2020 / PubMed / Full text
Remifentanil preconditioning protects against hypoxia-induced senescence and necroptosis in human cardiac myocytes [i]in vitro[/i]. / 25.06.2020 / PubMed / Full text
Crucial role of the terminal complement complex in chondrocyte death and hypertrophy after cartilage trauma. / 05.2020 / PubMed / Full text
Necroptosis increases with age and is reduced by dietary restriction. / 08.2018 / PubMed / Full text
RIPK1-RIPK3-MLKL-dependent necrosis promotes the aging of mouse male reproductive system. / 15.08.2017 / PubMed / Full text

MLN

Age-Dependent Decrease in the Induction of Regulatory T Cells Is Associated With Decreased Expression of RALDH2 in Mesenteric Lymph Node Dendritic Cells. / 2020 / PubMed / Full text
Variability of Spleen and Mesenteric Lymph Node in Control Cynomolgus Monkeys ( Macaca fascicularis) from Nonclinical Safety Studies: A Retrospective Assessment. / 01.2019 / PubMed / Full text
Microanatomical dissection of human intestinal T-cell immunity reveals site-specific changes in gut-associated lymphoid tissues over life. / 03.2019 / PubMed / Full text
Immunological Basis for Rapid Progression of Diabetes in Older NOD Mouse Recipients Post BM-HSC Transplantation. / 2015 / PubMed / Full text
Association between Mycobacterium avium subspecies paratuberculosis and lymph node size in New Zealand farmed deer (Cervus elaphus). / 05.2013 / PubMed / Full text

NBR1

Autophagy receptor OPTN (optineurin) regulates mesenchymal stem cell fate and bone-fat balance during aging by clearing FABP3. / 04.11.2020 / PubMed / Full text
New insights into AtNBR1 as a selective autophagy cargo receptor in Arabidopsis. / 30.10.2020 / PubMed / Full text
SQSTM1/p62 and PPARGC1A/PGC-1alpha at the interface of autophagy and vascular senescence. / 06.2020 / PubMed / Full text
Nrf2 mediates the expression of BAG3 and autophagy cargo adaptor proteins and tau clearance in an age-dependent manner. / 03.2018 / PubMed / Full text
Overweight in elderly people induces impaired autophagy in skeletal muscle. / 09.2017 / PubMed / Full text

NEDD8

Targeting Protein Neddylation for Cancer Therapy. / 2020 / PubMed / Full text
Effective targeting of the ubiquitin-like modifier NEDD8 for lung adenocarcinoma treatment. / 08.2020 / PubMed / Full text
Pevonedistat targeted therapy inhibits canine melanoma cell growth through induction of DNA re-replication and senescence. / 09.2020 / PubMed / Full text
Protein neddylation and its alterations in human cancers for targeted therapy. / 04.2018 / PubMed / Full text
Targeting protein neddylation with an NEDD8-activating enzyme inhibitor MLN4924 induced apoptosis or senescence in human lymphoma cells. / 2015 / PubMed / Full text

NFE2L2

The double-edged sword of MTOR in autophagy deficiency induced-liver injury and tumorigenesis. / 09.2019 / PubMed / Full text
The Association of a Single-Nucleotide Polymorphism in the Nuclear Factor (Erythroid-Derived 2)-Like 2 Gene With Adverse Drug Reactions, Multimorbidity, and Frailty in Older People. / 22.05.2020 / PubMed / Full text
Immunohistochemical localization of Nrf2 in the human cochlea. / 01.12.2018 / PubMed / Full text
Lifespan extension by peroxidase and dual oxidase-mediated ROS signaling through pyrroloquinoline quinone in [i]C. elegans[/i]. / 01.08.2017 / PubMed / Full text
Defective autophagy in vascular smooth muscle cells accelerates senescence and promotes neointima formation and atherogenesis. / 02.11.2015 / PubMed / Full text

NPC2

Attenuation of the Niemann-Pick type C2 disease phenotype by intracisternal administration of an AAVrh.10 vector expressing Npc2. / 08.2018 / PubMed / Full text
Quantification of age-related changes of α-tocopherol in lysosomal membranes in murine tissues and human fibroblasts. / 05.2016 / PubMed / Full text
Systemic administration of 2-hydroxypropyl-β-cyclodextrin to symptomatic Npc1-deficient mice slows cholesterol sequestration in the major organs and improves liver function. / 10.2014 / PubMed / Full text
Niemann-Pick C disease gene mutations and age-related neurodegenerative disorders. / 2013 / PubMed / Full text
Ontogenic changes in lung cholesterol metabolism, lipid content, and histology in mice with Niemann-Pick type C disease. / 01.2014 / PubMed / Full text

NRG1

Effects of neuregulin-1 administration on neurogenesis in the adult mouse hippocampus, and characterization of immature neurons along the septotemporal axis. / 29.07.2016 / PubMed / Full text
Neuregulin-1 Administration Protocols Sufficient for Stimulating Cardiac Regeneration in Young Mice Do Not Induce Somatic, Organ, or Neoplastic Growth. / 2016 / PubMed / Full text
Neuregulin 1 improves glucose tolerance in adult and old rats. / 04.2016 / PubMed / Full text
Disruption of hippocampal neuregulin 1-ErbB4 signaling contributes to the hippocampus-dependent cognitive impairment induced by isoflurane in aged mice. / 07.2014 / PubMed / Full text
ErbB2 receptor over-expression improves post-traumatic peripheral nerve regeneration in adult mice. / 2013 / PubMed / Full text

PDE4D

Phosphodiesterase PDE4D Is Decreased in Frontal Cortex of Aged Rats and Positively Correlated With Working Memory Performance and Inversely Correlated With PKA Phosphorylation of Tau. / 2020 / PubMed / Full text
Compound D159687, a phosphodiesterase 4D inhibitor, induces weight and fat mass loss in aged mice without changing lean mass, physical and cognitive function. / 02.12.2018 / PubMed / Full text
The isozyme selective phosphodiesterase-4 inhibitor, ABI-4, attenuates the effects of lipopolysaccharide in human cells and rodent models of peripheral and CNS inflammation. / 08.2017 / PubMed / Full text
Effects of aging on gene expression and mitochondrial DNA in the equine oocyte and follicle cells. / 07.2015 / PubMed / Full text
Select 3',5'-cyclic nucleotide phosphodiesterases exhibit altered expression in the aged rodent brain. / 02.2014 / PubMed / Full text

PDF

Effects of MUL1 and PARKIN on the circadian clock, brain and behaviour in Drosophila Parkinson's disease models. / 28.05.2019 / PubMed / Full text
Drosophila Clock Is Required in Brain Pacemaker Neurons to Prevent Premature Locomotor Aging Independently of Its Circadian Function. / 01.2017 / PubMed / Full text
SnapShot: Neuronal Regulation of Aging. / 28.07.2016 / PubMed / Full text
Recent data on Mediterranean diet, cardiovascular disease, cancer, diabetes and life expectancy. / 2015 / PubMed / Full text
Pigment-dispersing factor is involved in age-dependent rhythm changes in Drosophila melanogaster. / 12.2012 / PubMed / Full text

PIN1

Brain somatic mutations observed in Alzheimer's disease associated with aging and dysregulation of tau phosphorylation. / 12.07.2019 / PubMed / Full text
Class XI Myosins Contribute to Auxin Response and Senescence-Induced Cell Death in [i]Arabidopsis[/i]. / 2018 / PubMed / Full text
Effects of Melatonin and Its Underlying Mechanism on Ethanol-Stimulated Senescence and Osteoclastic Differentiation in Human Periodontal Ligament Cells and Cementoblasts. / 12.06.2018 / PubMed / Full text
Integrative Analysis of Hippocampus Gene Expression Profiles Identifies Network Alterations in Aging and Alzheimer's Disease. / 2018 / PubMed / Full text
Dynamic Phosphorylation of the Myocyte Enhancer Factor 2Cα1 Splice Variant Promotes Skeletal Muscle Regeneration and Hypertrophy. / 03.2017 / PubMed / Full text

PLAU

Data mining of human plasma proteins generates a multitude of highly predictive aging clocks that reflect different aspects of aging. / 11.2020 / PubMed / Full text
Identification of key genes and transcription factors in aging mesenchymal stem cells by DNA microarray data. / 15.04.2019 / PubMed / Full text
Towards frailty biomarkers: Candidates from genes and pathways regulated in aging and age-related diseases. / 11.2018 / PubMed / Full text
G protein-coupled receptor kinase 4-induced cellular senescence and its senescence-associated gene expression profiling. / 15.11.2017 / PubMed / Full text
Functional networks of aging markers in the glomeruli of IgA nephropathy: a new therapeutic opportunity. / 07.06.2016 / PubMed / Full text

POLD1

Epigenetic signatures of Werner syndrome occur early in life and are distinct from normal epigenetic aging processes. / 10.2019 / PubMed / Full text
POLD1 deficiency is involved in cognitive function impairment in AD patients and SAMP8 mice. / 06.2019 / PubMed / Full text
E2F1 mediates the downregulation of POLD1 in replicative senescence. / 07.2019 / PubMed / Full text
Mandibuloacral dysplasia: A premature ageing disease with aspects of physiological ageing. / 03.2018 / PubMed / Full text
POLD1: Central mediator of DNA replication and repair, and implication in cancer and other pathologies. / 15.09.2016 / PubMed / Full text

POU5F1

Cell quality evaluation with gene expression analysis of spheroids (3D) and adherent (2D) adipose stem cells. / 24.10.2020 / PubMed / Full text
Enhanced proliferative capacity of human preadipocytes achieved by an optimized cultivating method that induces transient activity of hTERT. / 20.08.2020 / PubMed / Full text
Autophagic homeostasis is required for the pluripotency of cancer stem cells. / 02.2017 / PubMed / Full text
Characterization of the POU5F1 Homologue in Nile Tilapia: From Expression Pattern to Biological Activity. / 15.09.2016 / PubMed / Full text
Determination phase at transition of gonocytes to spermatogonial stem cells improves establishment efficiency of spermatogonial stem cells in domestic cats. / 2015 / PubMed / Full text

PRMT1

Reactive oxygen species extend insect life span using components of the insulin-signaling pathway. / 12.09.2017 / PubMed / Full text
Regenerating muscle with arginine methylation. / 27.05.2017 / PubMed / Full text
Simultaneous ablation of prmt-1 and prmt-5 abolishes asymmetric and symmetric arginine dimethylations in Caenorhabditis elegans. / 01.06.2017 / PubMed / Full text
Caveolin1/protein arginine methyltransferase1/sirtuin1 axis as a potential target against endothelial dysfunction. / 05.2017 / PubMed / Full text
Epigallocatechin-3-gallate ameliorates erectile function in aged rats via regulation of PRMT1/DDAH/ADMA/NOS metabolism pathway. / 05-06.2017 / PubMed / Full text

RACK1

Invariable stoichiometry of ribosomal proteins in mouse brain tissues with aging. / 05.11.2019 / PubMed / Full text
Role of Hormones in the Regulation of RACK1 Expression as a Signaling Checkpoint in Immunosenescence. / 06.07.2017 / PubMed / Full text
Transcriptional regulation of RACK1 and modulation of its expression: Role of steroid hormones and significance in health and aging. / 07.2017 / PubMed / Full text
Role of androgens in dhea-induced rack1 expression and cytokine modulation in monocytes. / 2016 / PubMed / Full text
Immunostimulatory effects of RACK1 pseudosubstrate in human leukocytes obtained from young and old donors. / 30.03.2015 / PubMed / Full text

REN

In silico analysis of human renin gene-gene interactions and neighborhood topologically associated domains suggests breakdown of insulators contribute to ageing-associated diseases. / 12.2019 / PubMed / Full text
The Hispanic Paradox: Race/Ethnicity and Nativity, Immigrant Enclave Residence and Cognitive Impairment Among Older US Adults. / 05.2017 / PubMed / Full text
Analysis of Clinical Features and Outcomes of Skull Base Chordoma in Different Age-Groups. / 08.2016 / PubMed / Full text
Effects of advanced age and renal dysfunction on the single- and repeated-dose pharmacokinetics of modified-release flupirtine. / 03.2015 / PubMed / Full text
Mapping nutrient resorption efficiencies of subarctic cryptogams and seed plants onto the Tree of Life. / 06.2014 / PubMed / Full text

RHO

Conditional reprogramming: next generation cell culture. / 08.2020 / PubMed / Full text
SARS-CoV-2 receptor ACE2 and TMPRSS2 are primarily expressed in bronchial transient secretory cells. / 18.05.2020 / PubMed / Full text
Redox Signaling of NADPH Oxidases Regulates Oxidative Stress Responses, Immunity and Aging. / 28.09.2018 / PubMed / Full text
NADPH oxidase-mediated redox signaling promotes oxidative stress resistance and longevity through [i]memo-1[/i] in [i]C. elegans[/i]. / 13.01.2017 / PubMed / Full text
Guanine nucleotide exchange factor OSG-1 confers functional aging via dysregulated Rho signaling in Caenorhabditis elegans neurons. / 02.2015 / PubMed / Full text

RICTOR

Proteomics of Long-Lived Mammals. / 03.2020 / PubMed / Full text
Endothelial senescence-associated secretory phenotype (SASP) is regulated by Makorin-1 ubiquitin E3 ligase. / 11.2019 / PubMed / Full text
The underlying mechanism of proinflammatory NF-κB activation by the mTORC2/Akt/IKKα pathway during skin aging. / 16.08.2016 / PubMed / Full text
Depletion of Rictor, an essential protein component of mTORC2, decreases male lifespan. / 10.2014 / PubMed / Full text
Genetic analysis of TOR complex gene variation with human longevity: a nested case-control study of American men of Japanese ancestry. / 02.2015 / PubMed / Full text

RPE65

Effects of Ranibizumab, Bevacizumab, and Aflibercept on Senescent Retinal Pigment Epithelial Cells. / 08.2018 / PubMed / Full text
Age-related macular degeneration phenotypes are associated with increased tumor necrosis-alpha and subretinal immune cells in aged Cxcr5 knockout mice. / 2017 / PubMed / Full text
The amino acid transporter SLC36A4 regulates the amino acid pool in retinal pigmented epithelial cells and mediates the mechanistic target of rapamycin, complex 1 signaling. / 04.2017 / PubMed / Full text
Thinning of the RPE and choroid associated with T lymphocyte recruitment in aged and light-challenged mice. / 2015 / PubMed / Full text
Update on current and future novel therapies for dry age-related macular degeneration. / 09.2013 / PubMed / Full text

SDHB

Older Adults with Physical Frailty and Sarcopenia Show Increased Levels of Circulating Small Extracellular Vesicles with a Specific Mitochondrial Signature. / 15.04.2020 / PubMed / Full text
Oxidative Damage to the TCA Cycle Enzyme MDH1 Dysregulates Bioenergetic Enzymatic Activity in the Aged Murine Brain. / 03.04.2020 / PubMed / Full text
Mitochondrial Signatures in Circulating Extracellular Vesicles of Older Adults with Parkinson's Disease: Results from the EXosomes in PArkiNson's Disease (EXPAND) Study. / 12.02.2020 / PubMed / Full text
Mitochondrial bioenergetics and disease in Caenorhabditis elegans. / 01.01.2015 / PubMed / Full text
Long-term prognosis of patients with pediatric pheochromocytoma. / 02.2014 / PubMed / Full text

SFRP1

[Role and alterations of DNA methylation during the aging and cancer]. / 01.2018 / PubMed / Full text
Age-related increase in Wnt inhibitor causes a senescence-like phenotype in human cardiac stem cells. / 03.06.2017 / PubMed / Full text
Aging related methylation influences the gene expression of key control genes in colorectal cancer and adenoma. / 21.12.2016 / PubMed / Full text
The intrinsic stiffness of human trabecular meshwork cells increases with senescence. / 20.06.2015 / PubMed / Full text
Effects of age on bone mRNA levels of sclerostin and other genes relevant to bone metabolism in humans. / 02.2014 / PubMed / Full text

SMAD4

A clinical trial of somatic and germline analyses for healthy longevity in a postoperative cancer patient. / 09.2019 / PubMed / Full text
E47 Governs the MYC-CDKN1B/p27 -RB Network to Growth Arrest PDA Cells Independent of CDKN2A/p16 and Wild-Type p53. / 2018 / PubMed / Full text
iTRAQ-based proteomic profiling of granulosa cells from lamb and ewe after superstimulation. / 01.10.2017 / PubMed / Full text
miR-431 promotes differentiation and regeneration of old skeletal muscle by targeting Smad4. / 01.08.2015 / PubMed / Full text
Loss of smad4 in Sertoli and Leydig cells leads to testicular dysgenesis and hemorrhagic tumor formation in mice. / 03.2014 / PubMed / Full text

SMN2

Age-dependent SMN expression in disease-relevant tissue and implications for SMA treatment. / 01.11.2019 / PubMed / Full text
Type 0 Spinal Muscular Atrophy: Further Delineation of Prenatal and Postnatal Features in 16 Patients. / 29.11.2016 / PubMed / Full text
Systemic peptide-mediated oligonucleotide therapy improves long-term survival in spinal muscular atrophy. / 27.09.2016 / PubMed / Full text
Motor neuron disease. SMN2 splicing modifiers improve motor function and longevity in mice with spinal muscular atrophy. / 08.08.2014 / PubMed / Full text
Development and characterization of an SMN2-based intermediate mouse model of Spinal Muscular Atrophy. / 01.05.2013 / PubMed / Full text

SMS

Does a Live Performance Impact Synchronization to Musical Rhythm in Cognitively Impaired Elderly? / 2020 / PubMed / Full text
Testing the effectiveness of physical activity advice delivered via text messaging vs. human phone advisors in a Latino population: The On The Move randomized controlled trial design and methods. / 08.2020 / PubMed / Full text
Mobile Health Interventions for Physical Activity, Sedentary Behavior, and Sleep in Adults Aged 50 Years and Older: A Systematic Literature Review. / 01.08.2019 / PubMed / Full text
Senescence-messaging secretome factors trigger premature senescence in human endometrium-derived stem cells. / 19.02.2018 / PubMed / Full text
PAI-1-regulated extracellular proteolysis governs senescence and survival in Klotho mice. / 13.05.2014 / PubMed / Full text

SOCS1

Individual and combined effects of salinity and lipopolysaccharides on the immune response of juvenile Takifugu fasciatus. / 06.2019 / PubMed / Full text
SOCS1 regulates senescence and ferroptosis by modulating the expression of p53 target genes. / 28.10.2017 / PubMed / Full text
Daily Socs1 rhythms alter with aging differentially in peripheral clocks in male Wistar rats: therapeutic effects of melatonin. / 06.2017 / PubMed / Full text
Differential response to intrahippocampal interleukin-4/interleukin-13 in aged and exercise mice. / 20.02.2017 / PubMed / Full text
Aging diminishes the resistance of AO rats to EAE: putative role of enhanced generation of GM-CSF Expressing CD4 T cells in aged rats. / 2015 / PubMed / Full text

SP1

The effects and mechanism of collagen peptide and elastin peptide on skin aging induced by D-galactose combined with ultraviolet radiation. / 09.2020 / PubMed / Full text
Identification of key genes and transcription factors in aging mesenchymal stem cells by DNA microarray data. / 15.04.2019 / PubMed / Full text
Downregulation of CITED2 contributes to TGFβ-mediated senescence of tendon-derived stem cells. / 04.2017 / PubMed / Full text
Homocysteine accelerates senescence of endothelial cells via DNA hypomethylation of human telomerase reverse transcriptase. / 01.2015 / PubMed / Full text
A functional and genetic analysis of SOD2 promoter variants and their contribution to age-related hearing loss. / 07-08.2013 / PubMed / Full text

SSB

Modelling the Effects of Beverage Substitution during Adolescence on Later Obesity Outcomes in Early Adulthood: Results from the Raine Study. / 03.12.2019 / PubMed / Full text
WHIRLY1 Occupancy Affects Histone Lysine Modification and [i]WRKY53[/i] Transcription in [i]Arabidopsis[/i] Developmental Manner. / 2018 / PubMed / Full text
Modelled health benefits of a sugar-sweetened beverage tax across different socioeconomic groups in Australia: A cost-effectiveness and equity analysis. / 06.2017 / PubMed / Full text
Reduction of Sugar-Sweetened Beverage Consumption in Elementary School Students Using an Educational Curriculum of Beverage Sugar Content. / 2017 / PubMed / Full text
Interannual and Spatial Variability in Maturity of Walleye Pollock Gadus chalcogrammus and Implications for Spawning Stock Biomass Estimates in the Gulf of Alaska. / 2016 / PubMed / Full text

TBC1D1

Therapeutic and preventive effects of exercise on cardiometabolic parameters in aging and obese rats. / 02.2019 / PubMed / Full text
Calorie restriction leads to greater Akt2 activity and glucose uptake by insulin-stimulated skeletal muscle from old rats. / 01.03.2016 / PubMed / Full text
Insulin Signaling and Glucose Uptake in the Soleus Muscle of 30-Month-Old Rats After Calorie Restriction With or Without Acute Exercise. / 03.2016 / PubMed / Full text
Effects of sex and age on chicken TBC1D1 gene mRNA expression. / 13.07.2015 / PubMed / Full text
AMPK and insulin action--responses to ageing and high fat diet. / 2013 / PubMed / Full text

TGFB1

Different expression of Defensin-B gene in the endometrium of mares of different age during the breeding season. / 21.12.2019 / PubMed / Full text
TGFB1-Mediated Gliosis in Multiple Sclerosis Spinal Cords Is Favored by the Regionalized Expression of HOXA5 and the Age-Dependent Decline in Androgen Receptor Ligands. / 26.11.2019 / PubMed / Full text
Proteomic Alterations Associated with Biomechanical Dysfunction are Early Processes in the Emilin1 Deficient Mouse Model of Aortic Valve Disease. / 11.2017 / PubMed / Full text
Seminal plasma transforming growth factor-β, activin A and follistatin fluctuate within men over time. / 10.2016 / PubMed / Full text
No Association between Variation in Longevity Candidate Genes and Aging-related Phenotypes in Oldest-old Danes. / 06.2016 / PubMed / Full text

TLR1

Effects of aging and lifelong aerobic exercise on expression of innate immune components in human skeletal muscle. / 01.12.2020 / PubMed / Full text
Association of TLR gene variants in a Czech Red Pied cattle population with reproductive traits. / 02.2020 / PubMed / Full text
Decreased NLRP3 inflammasome expression in aged lung may contribute to increased susceptibility to secondary Streptococcus pneumoniae infection. / 05.2018 / PubMed / Full text
Changes in the expression of the Toll-like receptor system in the aging rat kidneys. / 2014 / PubMed / Full text
Reduced bioenergetics and toll-like receptor 1 function in human polymorphonuclear leukocytes in aging. / 02.2014 / PubMed / Full text

TLR8

Effects of aging and lifelong aerobic exercise on expression of innate immune components in human skeletal muscle. / 01.12.2020 / PubMed / Full text
TLR8-Mediated Metabolic Control of Human Treg Function: A Mechanistic Target for Cancer Immunotherapy. / 08.01.2019 / PubMed / Full text
Controlling T cell senescence in the tumor microenvironment for tumor immunotherapy. / 03.2015 / PubMed / Full text
Cathelicidin related antimicrobial peptide, laminin, Toll-like receptors and chemokines levels in experimental hypersensitivity pneumonitis in mice. / 06.2015 / PubMed / Full text
TLR8 signaling enhances tumor immunity by preventing tumor-induced T-cell senescence. / 10.2014 / PubMed / Full text

TMPRSS2

ACE2/ADAM17/TMPRSS2 Interplay May Be the Main Risk Factor for COVID-19. / 2020 / PubMed / Full text
Age-Dependent Assessment of Genes Involved in Cellular Senescence, Telomere, and Mitochondrial Pathways in Human Lung Tissue of Smokers, COPD, and IPF: Associations With SARS-CoV-2 COVID-19 ACE2-TMPRSS2-Furin-DPP4 Axis. / 2020 / PubMed / Full text
Susceptibility to COVID-19 in populations with health disparities: Posited involvement of mitochondrial disorder, socioeconomic stress, and pollutants. / 09.09.2020 / PubMed / Full text
Expression of the SARS-CoV-2 Entry Proteins, ACE2 and TMPRSS2, in Cells of the Olfactory Epithelium: Identification of Cell Types and Trends with Age. / 03.06.2020 / PubMed / Full text
SARS-CoV-2 receptor ACE2 and TMPRSS2 are primarily expressed in bronchial transient secretory cells. / 18.05.2020 / PubMed / Full text

TRH

Neonatal exposure to bisphenol A alters the hypothalamic-pituitary-thyroid axis in female rats. / 15.03.2018 / PubMed / Full text
Effect of dietary carbohydrates and time of year on ACTH and cortisol concentrations in adult and aged horses. / 04.2018 / PubMed / Full text
The role of Thyrotropin Releasing Hormone in aging and neurodegenerative diseases. / 2013 / PubMed / Full text
Aging-reversing properties of thyrotropin-releasing hormone. / 02.2013 / PubMed / Full text
Cancer-related fatigue, inflammation and thyrotropin-releasing hormone. / 12.2012 / PubMed / Full text

TRPM8

Morphological and functional changes in TRPM8-expressing corneal cold thermoreceptor neurons during aging and their impact on tearing in mice. / 01.08.2018 / PubMed / Full text
A comparative study on the therapeutic effect of TRPV1, TRPA1, and TRPM8 agonists on swallowing dysfunction associated with aging and neurological diseases. / 02.2018 / PubMed / Full text
Roles of TRPM8 Ion Channels in Cancer: Proliferation, Survival, and Invasion. / 23.10.2015 / PubMed / Full text
Function and postnatal changes of dural afferent fibers expressing TRPM8 channels. / 26.06.2015 / PubMed / Full text
Induction of oxidative stress causes functional alterations in mouse urothelium via a TRPM8-mediated mechanism: implications for aging. / 06.2014 / PubMed / Full text

VCP

The role of air pollution and lung function in cognitive impairment. / 02.2018 / PubMed / Full text
Better parameters of ventilation-CO₂output relationship predict death in CHF patients. / 11.2015 / PubMed
Valosin-containing protein is a key mediator between autophagic cell death and apoptosis in adult hippocampal neural stem cells following insulin withdrawal. / 22.03.2016 / PubMed / Full text
Frontotemporal dementia: insights into the biological underpinnings of disease through gene co-expression network analysis. / 24.02.2016 / PubMed / Full text
Characterization of C-terminal adaptors, UFD-2 and UFD-3, of CDC-48 on the polyglutamine aggregation in C. elegans. / 27.03.2015 / PubMed / Full text

WAS

Psychological stress exposure to aged mice causes abnormal feeding patterns with changes in the bout number. / 09.11.2017 / PubMed / Full text
Measuring Work Ability with Its Antecedents: Evaluation of the Work Ability Survey. / 06.2018 / PubMed / Full text
CONSTANCES: a general prospective population-based cohort for occupational and environmental epidemiology: cohort profile. / 01.2017 / PubMed / Full text
Age-Dependent Defects of Regulatory B Cells in Wiskott-Aldrich Syndrome Gene Knockout Mice. / 2015 / PubMed / Full text
Long-term anticoagulation in the extreme elderly with the newer antithrombotics: safe or sorry? / 05.2013 / PubMed / Full text