SQSTM1

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Sequestosome-1 (EBI3-associated protein of 60 kDa) (EBIAP) (p60) (Phosphotyrosine-independent ligand for the Lck SH2 domain of 62 kDa) (Ubiquitin-binding protein p62) [ORCA] [OSIL]

Publications[править]

The selective autophagy receptor SQSTM1/p62 improves lifespan and proteostasis in an evolutionarily conserved manner.


SQSTM1/p62 and PPARGC1A/PGC-1alpha at the interface of autophagy and vascular senescence.


SIRT2 functions in aging, autophagy, and apoptosis in post-maturation bovine oocytes.


A pH probe inhibits senescence in mesenchymal stem cells.


The ATG5-binding and coiled coil domains of ATG16L1 maintain autophagy and tissue homeostasis in mice independently of the WD domain required for LC3-associated phagocytosis.


Systemic overexpression of SQSTM1/p62 accelerates disease onset in a SOD1 -expressing ALS mouse model.


SIRT6 histone deacetylase functions as a potential oncogene in human melanoma.


SQSTM1/p62 mediates crosstalk between autophagy and the UPS in DNA repair.


Defective autophagy in vascular smooth muscle cells accelerates senescence and promotes neointima formation and atherogenesis.