REST

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RE1-silencing transcription factor (Neural-restrictive silencer factor) (X2 box repressor) [NRSF] [XBR]

Publications[править]

Transcriptional regulation of adult neural stem/progenitor cells: tales from the subventricular zone.


[Brain and Neuronal Aging: Aged Brain Controls via Gene Expression Fidelity and Master Regulatory Factors].


Effect of 9 - PAHSA on cognitive dysfunction in diabetic mice and its possible mechanism.


Increased REST to Optimize Life Span?


Regulation of lifespan by neural excitation and REST.


Cardiac baroreflex hysteresis is one of the determinants of the heart period variability asymmetry.


Pterostilbene Improves Cognitive Performance in Aged Rats: An in Vivo Study.


Comparison between probabilistic and Wiener-Granger causality in assessing modifications of the cardiac baroreflex control with age.


Fast-Evolving Human-Specific Neural Enhancers Are Associated with Aging-Related Diseases.

{{medline-entry |title=Influence of age and gender on the phase and strength of the relation between heart period and systolic blood pressure spontaneous fluctuations. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/29212671 |abstract=Aging affects baroreflex regulation. The effect of senescence on baroreflex control was assessed from spontaneous fluctuations of heart period (HP) and systolic arterial pressure (SAP) through the HP-SAP gain, while the HP-SAP phase and strength are usually disregarded. This study checks whether the HP-SAP phase and strength, as estimated, respectively, via the phase of the HP-SAP cross spectrum (Ph ) and squared coherence function (K ), vary with age in healthy individuals and trends are gender-dependent. We evaluated 110 healthy volunteers (55 males) divided into five age subgroups (21-30, 31-40, 41-50, 51-60, and 61-70 yr). Each subgroup was formed by 22 subjects (11 males). HP series was extracted from electrocardiogram and SAP from finger arterial pressure at supine resting (REST) and during active standing (STAND). Ph and K functions were sampled in low-frequency (LF, from 0.04 to 0.15 Hz) and in high-frequency (HF, above 0.15 Hz) bands. Both at REST and during STAND Ph (LF) showed a negative correlation with age regardless of gender even though values were more negative in women. This trend was shown to be compatible with a progressive increase of the baroreflex latency with age. At REST K (LF) decreased with age regardless of gender, but during STAND the high values of K (LF) were more preserved in men than women. At REST and during STAND the association of Ph (HF) and K (HF) with age was absent. The findings points to a greater instability of baroreflex control with age that seems to affect to a greater extent women than men. NEW