APOE

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Apolipoprotein E precursor (Apo-E)

Publications[править]

Polygenic risk score of longevity predicts longer survival across an age-continuum.


Association Between APOE Alleles and Change of Neuropsychological Tests in the Long Life Family Study.


The APOE gene cluster responds to air pollution factors in mice with coordinated expression of genes that differs by age in humans.


Homozygosity in the [i]APOE[/i] 3 Polymorphism Is Associated With Less Depression and Higher Serum Low-Density Lipoprotein in Chinese Elderly Schizophrenics.


Effect of apolipoprotein E polymorphism on cognition and brain in the Cambridge Centre for Ageing and Neuroscience cohort.


Cardiovascular risk factors and APOE-ε4 status affect memory functioning in aging via changes to temporal stem diffusion.


APOE [i]ε[/i]4 and resting-state functional connectivity in racially/ethnically diverse older adults.


Single Nucleotide Polymorphisms in Alzheimer's Disease Risk Genes Are Associated with Intrinsic Connectivity in Middle Age.


Microbleeds and Medial Temporal Atrophy Determine Cognitive Trajectories in Normal Aging: A Longitudinal PET-MRI Study.


Identification of cardiovascular health gene variants related to longevity in a Chinese population.


Predictors of Olfactory Decline in Aging: A Longitudinal Population-Based Study.


When Culture Influences Genes: Positive Age Beliefs Amplify the Cognitive-Aging Benefit of APOE ε2.


Age and the association between apolipoprotein E genotype and Alzheimer disease: A cerebrospinal fluid biomarker-based case-control study.


Estimating the potential for dementia prevention through modifiable risk factors elimination in the real-world setting: a population-based study.


Machine learning-based estimation of cognitive performance using regional brain MRI markers: the Northern Manhattan Study.


Genetic risk of dementia modifies obesity effects on white matter myelin in cognitively healthy adults.


Effects of an APOE Promoter Polymorphism on Fronto-Parietal Functional Connectivity During Nondemented Aging.


The relationship of parental longevity with the aging brain-results from UK Biobank.


Alzheimer's Patient Microglia Exhibit Enhanced Aging and Unique Transcriptional Activation.


Patterns of multi-domain cognitive aging in participants of the Long Life Family Study.


Genetics of Gene Expression in the Aging Human Brain Reveal TDP-43 Proteinopathy Pathophysiology.


Relationships Between Plasma Lipids Species, Gender, Risk Factors, and Alzheimer's Disease.


Effects of sex, age, and apolipoprotein E genotype on hippocampal parenchymal fraction in cognitively normal older adults.


Cognitive Health of Nonagenarians in Southern Italy: A Descriptive Analysis from a Cross-Sectional, Home-Based Pilot Study of Exceptional Longevity (Cilento Initiative on Aging Outcomes Or CIAO).


Apolipoprotein E and Health in Older Men: The Concord Health and Ageing in Men Project.


Volumetric alterations in the hippocampal subfields of subjects at increased risk of dementia.


CSF amyloid is a consistent predictor of white matter hyperintensities across the disease course from aging to Alzheimer's disease.


Association of Cardiovascular Risk Factors with Cerebral Perfusion in Whites and African Americans.


Alzheimer's Risk Factors Age, APOE Genotype, and Sex Drive Distinct Molecular Pathways.


Lack of UCP1 stimulates fatty liver but mediates UCP1-independent action of beige fat to improve hyperlipidemia in Apoe knockout mice.


Less agreeable, better preserved? A PET amyloid and MRI study in a community-based cohort.


Physical Activity as Moderator of the Association Between APOE and Cognitive Decline in Older Adults: Results from Three Longitudinal Cohort Studies.


Longitudinal Maintenance of Cognitive Health in Centenarians in the 100-plus Study.


Interaction of APOE, cerebral blood flow, and cortical thickness in the entorhinal cortex predicts memory decline.


Determinants of mesial temporal lobe volume loss in older individuals with preserved cognition: a longitudinal PET amyloid study.


Long-term exposure to ambient air pollution, APOE-ε4 status, and cognitive decline in a cohort of older adults in northern Manhattan.


Evidence in support of chromosomal sex influencing plasma based metabolome vs APOE genotype influencing brain metabolome profile in humanized APOE male and female mice.


Blood-based protein predictors of dementia severity as measured by δ: Replication across biofluids and cohorts.


Hippocampal Volume Loss, Brain Amyloid Accumulation, and APOE Status in Cognitively Intact Elderly Subjects.


Amyloid Load, Hippocampal Volume Loss, and Diffusion Tensor Imaging Changes in Early Phases of Brain Aging.


APOE ε4-specific associations of VEGF gene family expression with cognitive aging and Alzheimer's disease.


APOE region molecular signatures of Alzheimer's disease across races/ethnicities.


Anterior Cingulate Structure and Perfusion is Associated with Cerebrospinal Fluid Tau among Cognitively Normal Older Adult APOEɛ4 Carriers.


Genetic LAMP2 deficiency accelerates the age-associated formation of basal laminar deposits in the retina.


Varying Effects of APOE Alleles on Extreme Longevity in European Ethnicities.


Prospective Evaluation of Cognitive Health and Related Factors in Elderly at Risk for Developing Alzheimer's Dementia: A Longitudinal Cohort Study.


Association of Cardiovascular and Alzheimer's Disease Risk Factors with Intracranial Arterial Blood Flow in Whites and African Americans.


Is Ongoing Anticholinergic Burden Associated With Greater Cognitive Decline and Dementia Severity in Mild to Moderate Alzheimer's Disease?


Multicenter Alzheimer's and Parkinson's disease immune biomarker verification study.


Prospective Memory: Age related change is influenced by APOE genotype.


Education Moderates the Relation Between APOE ɛ4 and Memory in Nondemented Non-Hispanic Black Older Adults.


CLEC3B p.S106G Mutant in a Caucasian Population of Successful Neurological Aging.


Apolipoprotein E ε4 allele effects on longitudinal cognitive trajectories are sex and age dependent.


Interactive effect of age and APOE-ε4 allele load on white matter myelin content in cognitively normal middle-aged subjects.


APOE modifies the interaction of entorhinal cerebral blood flow and cortical thickness on memory function in cognitively normal older adults.


When time's arrow doesn't bend: APOE-ε4 influences episodic memory before old age.


Cognitive-Motor Integration Performance Is Affected by Sex, APOE Status, and Family History of Dementia.


Associations among amyloid status, age, and longitudinal regional brain atrophy in cognitively unimpaired older adults.


Cognitive function and neuropathological outcomes: a forward-looking approach.


APOE gene-dependent BOLD responses to a breath-hold across the adult lifespan.


Medial temporal lobe atrophy and posterior atrophy scales normative values.


Apolipoprotein E gene polymorphism, posttraumatic stress disorder, and cognitive function in older U.S. veterans: Results from the National Health and Resilience in Veterans Study.


Genetic background, epigenetic factors and dietary interventions which influence human longevity.


Adipose-Derived Stem/Stromal Cells Recapitulate Aging Biomarkers and Show Reduced Stem Cell Plasticity Affecting Their Adipogenic Differentiation Capacity.


Late life insulin resistance and Alzheimer's disease and dementia: The Kuakini Honolulu heart program.


Latent Classes of Cognitive Functioning Among Depressed Older Adults Without Dementia.


Lifespan Intellectual Factors, Genetic Susceptibility, and Cognitive Phenotypes in Aging: Implications for Interventions.


Cyclic O exposure synergizes with aging leading to memory impairment in male APOE ε3, but not APOE ε4, targeted replacement mice.


Alzheimer's disease and symbiotic microbiota: an evolutionary medicine perspective.


The role of APOE in transgenic mouse models of AD.


Sex differences in mixed neuropathologies in community-dwelling older adults.


Women Outperform Men in Verbal Episodic Memory Even in Oldest-Old Age: 13-Year Longitudinal Results of the AgeCoDe/AgeQualiDe Study.


APOE Effect on Amyloid-β PET Spatial Distribution, Deposition Rate, and Cut-Points.


Sex differences in the association of APOE ε4 genotype with longitudinal hippocampal atrophy in cognitively normal older people.


Predictors and Implications of Accelerated Cognitive Aging.


Association of Cortical β-Amyloid Protein in the Absence of Insoluble Deposits With Alzheimer Disease.


Sex differences in the association between amyloid and longitudinal brain volume change in cognitively normal older adults.


Region-specific association between basal blood insulin and cerebral glucose metabolism in older adults.


Association between APOE e4 and white matter hyperintensity volume, but not total brain volume or white matter integrity.


Cortical β-amyloid burden, neuropsychiatric symptoms, and cognitive status: the Mayo Clinic Study of Aging.


Nuances in Alzheimer's Genetic Risk Reveal Differential Predictions of Non-demented Memory Aging Trajectories: Selective Patterns by APOE Genotype and Sex.


A prospective study of focal brain atrophy, mobility and fitness.


10-year follow-up of the Super-Seniors Study: compression of morbidity and genetic factors.


Increases in a Pro-inflammatory Chemokine, MCP-1, Are Related to Decreases in Memory Over Time.


Taste receptors, innate immunity and longevity: the case of TAS2R16 gene.


The Role of APOE4 in Disrupting the Homeostatic Functions of Astrocytes and Microglia in Aging and Alzheimer's Disease.


The influence of tau, amyloid, alpha-synuclein, TDP-43, and vascular pathology in clinically normal elderly individuals.


Opposing Roles of apolipoprotein E in aging and neurodegeneration.


Effects of APOE on cognitive aging in community-dwelling older adults.


A candidate gene study of risk for dementia in older, postmenopausal women: Results from the Women's Health Initiative Memory Study.


Apolipoprotein E4 Mediates the Association Between Midlife Dyslipidemia and Cerebral Amyloid in Aging Women.


Apolipoprotein E gene in physiological and pathological aging.


Spatial patterns of white matter hyperintensities associated with Alzheimer's disease risk factors in a cognitively healthy middle-aged cohort.


The Role of MRI Biomarkers and Their Interactions with Cognitive Status and APOE ε4 in Nondemented Elderly Subjects.


Longitudinal tau accumulation and atrophy in aging and alzheimer disease.


Apolipoprotein E Genotypes, Age, Race, and Cognitive Decline in a Population Sample.


Predictors of neurodegeneration differ between cognitively normal and subsequently impaired older adults.


Vascular burden and APOE ε4 are associated with white matter microstructural decline in cognitively normal older adults.


Responses to executive demand in young adulthood differ by APOE genotype.


Mild Cognitive Impairment that Does Not Progress to Dementia: A Population-Based Study.


Neuropathologic, genetic, and longitudinal cognitive profiles in primary age-related tauopathy (PART) and Alzheimer's disease.


Independent associations of TOMM40 and APOE variants with body mass index.


Apolipoprotein E genotype moderates the association between dietary polyunsaturated fat and brain function: an exploration of cerebral glutamate and cognitive performance.


Circulating Vascular Growth Factors and Magnetic Resonance Imaging Markers of Small Vessel Disease and Atrophy in Middle-Aged Adults.


The 100-plus Study of cognitively healthy centenarians: rationale, design and cohort description.


Report: NIA workshop on translating genetic variants associated with longevity into drug targets.


Dendritic spine remodeling accompanies Alzheimer's disease pathology and genetic susceptibility in cognitively normal aging.


The ApoE ε4 Isoform: Can the Risk of Diseases be Reduced by Environmental Factors?


Genetics of Human Longevity From Incomplete Data: New Findings From the Long Life Family Study.


Amygdala subnuclei and healthy cognitive aging.


APOE ɛ4, rs405509, and rs440446 promoter and intron-1 polymorphisms and dementia risk in a cohort of elderly Finns-Helsinki Birth Cohort Study.


The Cross-sectional and Longitudinal Associations Between IL-6, IL-10, and TNFα and Cognitive Outcomes in the Mayo Clinic Study of Aging.


The effect of midlife cardiovascular risk factors on white matter hyperintensity volume and cognition two decades later in normal ageing women.


Sex and age interact to determine clinicopathologic differences in Alzheimer's disease.


Relationship Between Amyloid-β Positivity and Progression to Mild Cognitive Impairment or Dementia over 8 Years in Cognitively Normal Older Adults.


Lifetime Risk Factors for Functional and Cognitive Outcomes in Patients with Alzheimer's Disease.


Microglial translational profiling reveals a convergent APOE pathway from aging, amyloid, and tau.


Childhood socioeconomic status and genetic risk for poorer cognition in later life.


Diffuse Amyloid-β Plaques, Neurofibrillary Tangles, and the Impact of APOE in Elderly Persons' Brains Lacking Neuritic Amyloid Plaques.


Polygenic analysis of inflammatory disease variants and effects on microglia in the aging brain.


Dual-Task Gait and Alzheimer's Disease Genetic Risk in Cognitively Normal Adults: A Pilot Study.

{{medline-entry |title=Higher Aortic Stiffness Is Related to Lower Cerebral Blood Flow and Preserved Cerebrovascular Reactivity in Older Adults. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/30018169 |abstract=Mechanisms underlying the association between age-related arterial stiffening and poor brain health remain elusive. Cerebral blood flow (CBF) homeostasis may be implicated. This study evaluates how aortic stiffening relates to resting CBF and cerebrovascular reactivity (CVR) in older adults. Vanderbilt Memory