CD14

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Monocyte differentiation antigen CD14 precursor (Myeloid cell-specific leucine-rich glycoprotein) (CD14 antigen) [Contains: Monocyte differentiation antigen CD14, urinary form; Monocyte differentiation antigen CD14, membrane-bound form]

Publications[править]

Human innate immune cell crosstalk induces melanoma cell senescence.


Lipopolysaccharide binding protein is associated with CVD risk in older adults.


Fusion Potential of Human Osteoclasts In Vitro Reflects Age, Menopause, and In Vivo Bone Resorption Levels of Their Donors-A Possible Involvement of DC-STAMP.


Changes in salivary microbial sensing proteins CD14 and TLR2 with aging.


Association of CD14 with incident dementia and markers of brain aging and injury.


Compromised Bone Healing in Aged Rats Is Associated With Impaired M2 Macrophage Function.


Adipose-Derived Stem/Stromal Cells Recapitulate Aging Biomarkers and Show Reduced Stem Cell Plasticity Affecting Their Adipogenic Differentiation Capacity.


Increased monocyte activation with age among HIV-infected long term non-progressor children: implications for early treatment initiation.


Wheat seed ageing viewed through the cellular redox environment and changes in pH.


Senescent Phenotype Induced by p90RSK-NRF2 Signaling Sensitizes Monocytes and Macrophages to Oxidative Stress in HIV-Positive Individuals.


Effects of pepsin and pepstatin on reflux tonsil hypertrophy in vitro.


Innate and adaptive immune dysregulation in critically ill ICU patients.


Serum Zonulin and Endotoxin Levels in Exceptional Longevity versus Precocious Myocardial Infarction.


Rapid Turnover and High Production Rate of Myeloid Cells in Adult Rhesus Macaques with Compensations during Aging.


Human colostrum action against Giardia lamblia infection influenced by hormones and advanced maternal age.


The pro-inflammatory phenotype of the human non-classical monocyte subset is attributed to senescence.


Aged Chinese-origin rhesus macaques infected with SIV develop marked viremia in absence of clinical disease, inflammation or cognitive impairment.


Stem Cells and Progenitors in Human Peripheral Blood Get Activated by Extremely Active Resveratrol (XAR™).


Acute Effects of Nitrate-Rich Beetroot Juice on Blood Pressure, Hemostasis and Vascular Inflammation Markers in Healthy Older Adults: A Randomized, Placebo-Controlled Crossover Study.


Proteomic profiling of follicle fluids after superstimulation in one-month-old lambs.


Latent Cytomegalovirus (CMV) Infection Does Not Detrimentally Alter T Cell Responses in the Healthy Old, But Increased Latent CMV Carriage Is Related to Expanded CMV-Specific T Cells.


HIV and Obesity Comorbidity Increase Interleukin 6 but Not Soluble CD14 or D-Dimer.


Immunosenescence Induced by Plasma from Individuals with Obesity Caused Cell Signaling Dysfunction and Inflammation.


β -Microglobulin participates in development of lung emphysema by inducing lung epithelial cell senescence.


Age-dependent cellular reactions of the human immune system of humanized NOD scid gamma mice on LPS stimulus.


Immune Activation and Bacterial Translocation: A Link between Impaired Immune Recovery and Frequent Visceral Leishmaniasis Relapses in HIV-Infected Patients.


Impaired phagocytosis of apoptotic cells causes accumulation of bone marrow-derived macrophages in aged mice.


Do Biomarkers of Inflammation, Monocyte Activation, and Altered Coagulation Explain Excess Mortality Between HIV Infected and Uninfected People?


Strain-dependent response to stimulation in middle-aged rat macrophages: A quest after a useful indicator of healthy aging.


Distinct inflammatory phenotypes of microglia and monocyte-derived macrophages in Alzheimer's disease models: effects of aging and amyloid pathology.


Red Wine Prevents the Acute Negative Vascular Effects of Smoking.


T-Cell Activation Independently Associates With Immune Senescence in HIV-Infected Recipients of Long-term Antiretroviral Treatment.


Cytomegalovirus viral load within blood increases markedly in healthy people over the age of 70 years.


Elevated Levels of Microbial Translocation Markers and CCL2 Among Older HIV-1-Infected Men.


Persistent Immune Activation and Carotid Atherosclerosis in HIV-Infected Ugandans Receiving Antiretroviral Therapy.


Visceral leishmaniasis as an independent cause of high immune activation, T-cell senescence, and lack of immune recovery in virologically suppressed HIV-1-coinfected patients.


Aging oppositely affects TNF-α and IL-10 production by macrophages from different rat strains.


Age-related changes in the features of porcine adult stem cells isolated from adipose tissue and skeletal muscle.


Lower levels of circulating progenitor cells are associated with low physical function and performance in elderly men with impaired glucose tolerance: a pilot substudy from the VA Enhanced Fitness trial.


Menopause leads to elevated expression of macrophage-associated genes in the aging frontal cortex: rat and human studies identify strikingly similar changes.


Lipopolysaccharide-binding protein, a surrogate marker of microbial translocation, is associated with physical function in healthy older adults.

{{medline-entry |title=ESeroS-GS modulates lipopolysaccharide-induced macrophage activation by impairing the assembly of TLR-4 complexes in lipid rafts. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/21276822 |abstract=The binding of lipopolysaccharides (LPS) to macrophages results in inflammatory responses. In extreme cases it can lead to endotoxic shock, often resulting in death. A broad range of antioxidants, including tocopherols, can reduce LPS activity in vitro and in vivo. To elucidate the underlying mechanisms of their action, we investigated the effect of the sodium salt of γ-L-glutamyl-S-[2-[[[3,4-dihydro-2,5,7,8-tetramethyl-2-(4,8,12-trimethyltridecyl)-2H-1-benzopyran-6-yl]oxy]carbonyl]-3-[[2-(1H-indol-3-yl)ethyl]amino]-3-oxopropyl]-L-cysteinylglycine (ESeroS-GS), a novel α-tocopherol derivative, on LPS-induced inflammation in vitro and in vivo. ESeroS-GS reduced the transcription of TNF-α, IL-1β, IL-6 and iNOS genes in a dose-dependent manner in RAW264.7 macrophages, and inhibited the release of these inflammatory factors. In addition, ESeroS-GS inhibited LPS-induced mortality in a mouse sepsis model. Electrophoretic mobility shift assays (EMSA) and reporter gene assays revealed that ESeroS-GS down-regulated the transcriptional activity of NF-κB. By analyzing the partitioning of CD14 and Toll-like receptor 4 (TLR-4) in cell membrane microdomains, we found that ESeroS-GS attenuates the binding of LPS to RAW264.7 cells via interfering with the relocation of CD14 and TLR-4 to lipid rafts, blocking the activation of interleukin-1 receptor-associated kinase 1 (IRAK-1), and inhibiting the consequent phosphorylation of TAK1 and IKKα/β, which together account for the suppression of NF-κB activation. Taken together, our data suggest that ESeroS-GS can modulate LPS signaling in macrophages by impairing TLR-4 complex assembly via a lipid raft dependent mechanism. This article is part of a Special Issue entitled: 11th European Symposium on Calcium. |mesh-terms=* Animals

  • Benzopyrans
  • Cell Line
  • Cytokines
  • Down-Regulation
  • Fluorescein-5-isothiocyanate
  • I-kappa B Kinase
  • Indoles
  • Inflammation Mediators
  • Interleukin-1 Receptor-Associated Kinases
  • Lipopolysaccharide Receptors
  • Lipopolysaccharides
  • Longevity
  • MAP Kinase Kinase Kinases
  • Macrophage Activation
  • Macrophages
  • Male
  • Membrane Microdomains
  • Mice
  • Mice, Inbred C57BL
  • Models, Biological
  • Multiprotein Complexes
  • NF-kappa B
  • Nitric Oxide
  • Nitric Oxide Synthase Type II
  • Phosphorylation
  • Sepsis
  • Toll-Like Receptor 4

|full-text-url=https://sci-hub.do/10.1016/j.bbamcr.2011.01.019 }}

Periodontal inflammation and bone loss in aged mice.


Aging-related hyperinflammation in endotoxemia is mediated by the alpha2A-adrenoceptor and CD14/TLR4 pathways.


Natural killer cell number and phenotype in bovine peripheral blood is influenced by age.


Developments in the scientific and clinical understanding of gout.


Standardized method to minimize variability in a functional P2X(7) flow cytometric assay for a multi-center clinical trial.


Ontogeny of systemic cellular immunity in the neonatal pig: correlation with the development of post-weaning multisystemic wasting syndrome.


Innate immune receptor expression in normal brain aging.


Immaturity of infection control in preterm and term newborns is associated with impaired toll-like receptor signaling.


The endometrium of the anoestrous female pig: studies on infiltration by cells of the immune system.


Effects of heat shock and hypoxia on neonatal neutrophil lipopolysaccharide responses: altered apoptosis, Toll-like receptor-4 and CD11b expression compared with adults.


The unresponsiveness of aged mice to polysaccharide antigens is a result of a defect in macrophage function.


The differential effect of genetic variation on soluble CD14 levels in human plasma and milk.


Age and caloric restriction diets are confounding factors that modify the response to lipopolysaccharide by peritoneal macrophages in C57BL/6 mice.


A genetic basis for the "Adonis" phenotype of low adiposity and strong bones.


Reduced levels of soluble CD14 in atopic children.


Effects of dog ownership and genotype on immune development and atopy in infancy.


Effect of the CD14 promoter polymorphism on liver function tests and its association with alcohol and obesity.


Age-related increases in LPS-stimulated nitric oxide production from cultured rat bone marrow cells.


Toll-like receptor 4 and CD14 mRNA expression are lower in resistive exercise-trained elderly women.


Differences in circulating dendritic cell subtypes in cord blood and peripheral blood of healthy and allergic children.


Developmental changes in interleukin-12-producing ability by monocytes and their relevance to allergic diseases.


CD14 and development of atopic disease at 2 years of age in children with atopic or non-atopic mothers.


Aging accelerates endotoxin-induced thrombosis : increased responses of plasminogen activator inhibitor-1 and lipopolysaccharide signaling with aging.


Increased cytokine release by leucocytes in survivors of stroke at young age.


Augmented age-associated innate immune responses contribute to negative inotropic and lusitropic effects of lipopolysaccharide and interferon gamma.


Effects of calorie restriction on polymicrobial peritonitis induced by cecum ligation and puncture in young C57BL/6 mice.


Analysis of stem cell apheresis products using intermediate-dose filgrastim plus large volume apheresis for allogeneic transplantation.


Unimpaired dendritic cells can be derived from monocytes in old age and can mobilize residual function in senescent T cells.


Is irregular regression of corpora lutea in climacteric women caused by age-induced alterations in the "tissue control system"?


Immunological parameters in current and former US Air Force personnel.


Monoclonal antibodies in myeloid diseases: prognostic use in acute myeloid leukaemia.
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