CD28

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T-cell-specific surface glycoprotein CD28 precursor (TP44) (CD28 antigen)

Publications[править]

Premature CD4 T Cells Senescence Induced by Chronic Infection in Patients with Acute Coronary Syndrome.


Immunosenescence: a key player in cancer development.


The IMMENSE Study: The Interplay Between iMMune and ENdothelial Cells in Mediating Cardiovascular Risk in Systemic Lupus Erythematosus.


Emergence of T cell immunosenescence in diabetic chronic kidney disease.


The relationship between Chlamydia pneumoniae infection and CD4/CD8 ratio, lymphocyte subsets in middle-aged and elderly individuals.


Next steps in mechanisms of inflammaging.


A randomized pilot trial to evaluate the benefit of the concomitant use of atorvastatin and Raltegravir on immunological markers in protease-inhibitor-treated subjects living with HIV.


Characterization of KIR  NKG2A  Eomes- NK-like CD8 T cells and their decline with age in healthy individuals.


Aging affects responsiveness of peripheral blood mononuclear cells to immunosuppression of periodontal ligament stem cells.


Comparison of Donepezil, Memantine, Melatonin, and Liuwei Dihuang Decoction on Behavioral and Immune Endocrine Responses of Aged Senescence-Accelerated Mouse Resistant 1 Mice.


Association of Epigenetic Age and p16INK4a With Markers of T-Cell Composition in a Healthy Cohort.


CD4 T helper 17 cell response of aged mice promotes prostate cancer cell migration and invasion.


Lymphocyte senescence in COPD is associated with decreased sirtuin 1 expression in steroid resistant pro-inflammatory lymphocytes.


Immunosenescent characteristics of T cells in young patients following haploidentical haematopoietic stem cell transplantation from parental donors.


Diagnosis-independent loss of T-cell costimulatory molecules in individuals with cytomegalovirus infection.


Accelerated immunosenescence in rheumatoid arthritis: impact on clinical progression.


Accelerated immune aging was correlated with lupus-associated brain fog in reproductive-age systemic lupus erythematosus patients.


T cells, aging and senescence.


Liver fibrosis and accelerated immune dysfunction (immunosenescence) among HIV-infected Russians with heavy alcohol consumption - an observational cross-sectional study.


Effect of Allogenic Bone Marrow Mesenchymal Stem Cell Transplantation on T Cells of Old Mice.


Peripheral antibody concentrations are associated with highly differentiated T cells and inflammatory processes in the human bone marrow.


T Cell Transcriptional Profiling and Immunophenotyping Uncover LAG3 as a Potential Significant Target of Immune Modulation in Multiple Myeloma.


Collaboration of MYC and RUNX2 in lymphoma simulates T-cell receptor signaling and attenuates p53 pathway activity.


The Evolving Role of CD8 CD28 Immunosenescent T Cells in Cancer Immunology.


Are skin senescence and immunosenescence linked within individuals?


Expanded peripheral CD4 CD28 T cells and its association with atherosclerotic changes in patients with end stage renal disease on hemodialysis.


Impact of aging on inflammatory and immune responses during elastin peptide-induced murine emphysema.


Low DNA damage in peripheral lymphocytes of healthy elderly individuals with inverted CD4:CD8 ratio.


Post-thymic CD4 positive cytotoxic T cell infiltrates of the skin: A clinical and histomorphologic spectrum of the unique CD4 positive T cell of immunosenescence.


Immune Response-Dependent Assembly of IMP Dehydrogenase Filaments.


Reduced expression of the lncRNA NRON is a potential hallmark of the CMV-amplified CD8 T cell accumulations commonly seen in older humans.


Low IL-2 Expressing T Cells in Thalassemia Major Patients: Is It Immune Aging.


CD28 pro-atherogenic CD4 T-cells explain the link between CMV infection and an increased risk of cardiovascular death.


Senescence markers: Predictive for response to checkpoint inhibitors.


An imbalance in the T-helper phenotypes displayed by senescent CD4 CD28 T cells is associated with erosive arthritis (rhupus syndrome) in systemic lupus erythematosus.


Features of Immunosenescence in Women Newly Diagnosed With Breast Cancer.


Innate and adaptive immune dysregulation in critically ill ICU patients.


Is Chronic Exposure to Low-Dose Organochlorine Pesticides a New Risk Factor of T-cell Immunosenescence?


Involvement of MicroRNAs in the Aging-Related Decline of CD28 Expression by Human T Cells.


Older men display elevated levels of senescence-associated exercise-responsive CD28 angiogenic T cells compared with younger men.


Multi-color flow cytometry for evaluating age-related changes in memory lymphocyte subsets in dogs.


Abnormalities of age-related T cell senescence in Parkinson's disease.


CD57 identifies T cells with functional senescence before terminal differentiation and relative telomere shortening in patients with activated PI3 kinase delta syndrome.


Low cytomegalovirus seroprevalence in early multiple sclerosis: a case for the 'hygiene hypothesis'?


Senescent T-Cells Promote Bone Loss in Rheumatoid Arthritis.


T-cell Immunoglobulin and ITIM Domain Contributes to CD8 T-cell Immunosenescence.


Signal transduction changes in CD4 and CD8 T cell subpopulations with aging.


Increased senescent CD8 T cells in the peripheral blood mononuclear cells of Behçet's disease patients.


Immune parameters associated with mortality in the elderly are context-dependent: lessons from Sweden, Holland and Belgium.


T-cell differentiation and CD56 levels in polypoidal choroidal vasculopathy and neovascular age-related macular degeneration.


[Effects of serums containing Buzhong Yiqi decoction with Astragalus Radix or Hedysari Radix on anti-immunosenescence in spleen lymphocytes of SAMP8 mice].


Arterial Stiffness Is Associated With Cytomegalovirus-Specific Senescent CD8 T Cells.


Human endogenous retrovirus HERV-K(HML-2) env expression is not associated with markers of immunosenescence.


Assessing inflammageing.


Immunosenescence Induced by Plasma from Individuals with Obesity Caused Cell Signaling Dysfunction and Inflammation.


Increased IL-15 Production and Accumulation of Highly Differentiated CD8 Effector/Memory T Cells in the Bone Marrow of Persons with Cytomegalovirus.


Structural characterization of a pectic polysaccharide from Codonopsis pilosula and its immunomodulatory activities in vivo and in vitro.


Impact of age and cytomegalovirus on CD8 T-cell compartment remodeling after solid organ transplantation: A one-year follow-up study.


Long-term calorie restriction in humans is not associated with indices of delayed immunologic aging: A descriptive study.


Novel Senescent Regulatory T-Cell Subset with Impaired Suppressive Function in Rheumatoid Arthritis.


Melatonin: Antioxidant and modulatory properties in age-related changes during Trypanosoma cruzi infection.


Consumption of green tea epigallocatechin-3-gallate enhances systemic immune response, antioxidative capacity and HPA axis functions in aged male swiss albino mice.


Lymph node and circulating T cell characteristics are strongly correlated in end-stage renal disease patients, but highly differentiated T cells reside within the circulation.


Therapeutic effect of human ghrelin and growth hormone: Attenuation of immunosuppression in septic aged rats.


Mechanisms Underlying T Cell Immunosenescence: Aging and Cytomegalovirus Infection.


The influences of age on T lymphocyte subsets in C57BL/6 mice.


Adaptive Memory of Human NK-like CD8 T-Cells to Aging, and Viral and Tumor Antigens.


"Inflamm-aging" influences immune cell survival factors in human bone marrow.


Circulating T Cells of Patients with Nijmegen Breakage Syndrome Show Signs of Senescence.


Phenotypic characteristics of aged CD4 CD28 T lymphocytes are determined by changes in the whole-genome DNA methylation pattern.


Age-related changes in the gene expression profile of antigen-specific mouse CD8 T cells can be partially reversed by blockade of the BTLA/CD160 pathways during vaccination.


Effects of Physical Exercise on Markers of Cellular Immunosenescence: A Systematic Review.


Immunosenescence-Related Transcriptomic and Immunologic Changes in Older Individuals Following Influenza Vaccination.


T cells in multiple myeloma display features of exhaustion and senescence at the tumor site.


Steroid resistance in COPD is associated with impaired molecular chaperone Hsp90 expression by pro-inflammatory lymphocytes.


Impact of aging on host immune response and survival in melanoma: an analysis of 3 patient cohorts.


Pharmacological advantages of melatonin in immunosenescence by improving activity of T lymphocytes.


T Cells Going Innate.


Effects of Heavy Drinking on T-Cell Phenotypes Consistent with Immunosenescence in Untreated HIV Infection.


Inflammatory and immune markers associated with physical frailty syndrome: findings from Singapore longitudinal aging studies.


Alteration of T Cell Subtypes in Beta-Thalassaemia Major: Impact of Ferritin Level.


Aging of immune system: Immune signature from peripheral blood lymphocyte subsets in 1068 healthy adults.


PTSD is associated with an increase in aged T cell phenotypes in adults living in Detroit.


Genetic Influence on the Peripheral Blood CD4 T-cell Differentiation Status in CMV Infection.


Shifts in subsets of CD8 T-cells as evidence of immunosenescence in patients with cancers affecting the lungs: an observational case-control study.


Biomarkers related to immunosenescence: relationships with therapy and survival in lung cancer patients.


Poor survival in glioblastoma patients is associated with early signs of immunosenescence in the CD4 T-cell compartment after surgery.


Aging-associated subpopulations of human CD8 T-lymphocytes identified by their CD28 and CD57 phenotypes.


Senescent profile of angiogenic T cells from systemic lupus erythematosus patients.


Cardio-metabolic and immunological impacts of extra virgin olive oil consumption in overweight and obese older adults: a randomized controlled trial.


CD4⁺CD28null T lymphocytes resemble CD8⁺CD28null T lymphocytes in their responses to IL-15 and IL-21 in HIV-infected patients.


Activation-induced and damage-induced cell death in aging human T cells.


The impact of immunosenescence on humoral immune response variation after influenza A/H1N1 vaccination in older subjects.


Chemotherapy-induced changes and immunosenescence of CD8 T-cells in patients with breast cancer.


Increased frequency of late-senescent T cells lacking CD127 in chronic hepatitis C disease.


Heat-killed Lactobacillus gasseri can enhance immunity in the elderly in a double-blind, placebo-controlled clinical study.


Increased vitamin D is associated with decline of naïve, but accumulation of effector, CD8 T cells during early aging.


Immune resilience in HIV-infected individuals seronegative for cytomegalovirus.


The effects of age and cytomegalovirus on markers of inflammation and lymphocyte populations in captive baboons.


γ/δ T cell subsets in human aging using the classical α/β T cell model.


Decreased c-rel activation contributes to aberrant interleukin-2 expression in CD4( )T cells of aged rats.


Low proportions of CD28- CD8 T cells expressing CD57 can be reversed by early ART initiation and predict mortality in treated HIV infection.


Impact of HIV on CD8 T cell CD57 expression is distinct from that of CMV and aging.


Age-associated aberrations in mouse cellular and humoral immune responses.


Decreased proportion of cytomegalovirus specific CD8 T-cells but no signs of general immunosenescence in Alzheimer's disease.


Cytomegalovirus (CMV)-dependent and -independent changes in the aging of the human immune system: a transcriptomic analysis.


The polyfunctionality of human memory CD8 T cells elicited by acute and chronic virus infections is not influenced by age.


Ex vivo enzymatic treatment of aged CD4 T cells restores cognate T cell helper function and enhances antibody production in mice.


T cell replicative senescence in human aging.


Age-related expansion of Tim-3 expressing T cells in vertically HIV-1 infected children.


Aging, inflammation, and HIV infection.


CD8 CD45RA CCR7 FOXP3 T cells with immunosuppressive properties: a novel subset of inducible human regulatory T cells.


CD40, CD45 CTLA-4 levels are elevated in healthy older adults.


Lower proportion of naïve peripheral CD8 T cells and an unopposed pro-inflammatory response to human Cytomegalovirus proteins in vitro are associated with longer survival in very elderly people.


Correlation between T lymphocyte subsets in peripheral blood lymphocytes and 2-year all-cause mortality in an apparently healthy elderly Chinese cohort.


Impact of cytomegalovirus on early immunosenescence of CD8 T lymphocytes after solid organ transplantation.


Signaling pathways in aged T cells - a reflection of T cell differentiation, cell senescence and host environment.


[Changes and effects of significant membrane molecules on thymic T cell of aging mice induced by D-galactose].


Immune senescence in old and very old rhesus monkeys: reduced antibody response to influenza vaccination.


Cellular aging and senescence characteristics of human T-lymphocytes.


Non-melanoma skin cancers in elderly patients.


Transcriptomic biomarkers of the response of hospitalized geriatric patients admitted with heart failure. Comparison to hospitalized geriatric patients with infectious diseases or hip fracture.


Age-related impairment of T cell-induced skeletal muscle precursor cell function.


NKG2D expression in CD4 T lymphocytes as a marker of senescence in the aged immune system.


Cytomegalovirus infection induces the accumulation of short-lived, multifunctional CD4 CD45RA CD27 T cells: the potential involvement of interleukin-7 in this process.


Differentially abundant transcripts in PBMC of hospitalized geriatric patients with hip fracture compared to healthy aged controls.


Impact of age on T cell signaling: a general defect or specific alterations?


Hypoxic exercise training reduces senescent T-lymphocyte subsets in blood.


Varying expression of four genes sharing a common regulatory sequence may differentiate rheumatoid arthritis from ageing effects on the CD4( ) lymphocytes.


Sustained CD28 expression delays multiple features of replicative senescence in human CD8 T lymphocytes.


Partial restoration of T-cell function in aged mice by in vitro blockade of the PD-1/ PD-L1 pathway.


Natural killer T cells constitutively expressing the interleukin-2 receptor α chain early in life are primed to respond to lower antigenic stimulation.


Gender specificity of altered human immune cytokine profiles in aging.


B7-H1 expression on old CD8 T cells negatively regulates the activation of immune responses in aged animals.


Transcriptomic biomarkers of human ageing in peripheral blood mononuclear cell total RNA.


The aging immune system and its relationship to the development of chronic obstructive pulmonary disease.


IL-21 preferentially enhances IL-15-mediated homeostatic proliferation of human CD28 CD8 memory T cells throughout the adult age span.


The relationship between cell surface markers, cytokines, ageing, and cigarette smoking.


IL-2 regulates CD103 expression on CD4 T cells in Scurfy mice that display both CD103-dependent and independent inflammation.


CD28(-) T cells: their role in the age-associated decline of immune function.


Age-associated up-regulation of a negative co-stimulatory receptor PD-1 in mouse CD4 T cells.


Vitamin E reverses impaired linker for activation of T cells activation in T cells from aged C57BL/6 mice.


Memory T cells need CD28 costimulation to remember.


Effect of moderate exercise training on T-helper cell subpopulations in elderly people.


Premature aging of T cells is associated with faster HIV-1 disease progression.


Adiponectin deficiency does not affect development and progression of spontaneous colitis in IL-10 knockout mice.


The use of the inhibitory receptors for modulating the immune responses.


Aging-related differences in basal heat shock protein 70 levels in lymphocytes are linked to altered frequencies of lymphocyte subsets.


Senescent T-lymphocytes are mobilised into the peripheral blood compartment in young and older humans after exhaustive exercise.


IL-2 induces and altered CD4/CD8 ratio of splenic T lymphocytes from transgenic mice overexpressing the glucocorticoid-induced protein GILZ.


The immune system in extreme longevity.


Age-related changes in the occurrence and characteristics of thymic CD4( ) CD25( ) T cells in mice.


Do membrane rafts contribute to human immunosenescence?


The cytomegalovirus-specific CD4 T-cell response expands with age and markedly alters the CD4 T-cell repertoire.


CD56-expressing T cells that have features of senescence are expanded in rheumatoid arthritis.


Klotho--a common link in physiological and rheumatoid arthritis-related aging of human CD4 lymphocytes.


Telomerase induction in T cells: a cure for aging and disease?


Generation and growth of CD28nullCD8 memory T cells mediated by IL-15 and its induced cytokines.


Age and vitamin E-induced changes in gene expression profiles of T cells.


Complexity of anti-immunosenescence strategies in humans.


Role of T lymphocyte replicative senescence in vaccine efficacy.


Decreased frequency and proliferative response of invariant Valpha24Vbeta11 natural killer T (iNKT) cells in healthy elderly.


Negative regulation of interleukin-2 and p38 mitogen-activated protein kinase during T-cell activation by the adaptor ALX.


High frequencies cytomegalovirus pp65(495-503)-specific CD8 T cells in healthy young and elderly Chinese donors: characterization of their phenotypes and TCR Vbeta usage.


Age-dependent effects of in vitro radiofrequency exposure (mobile phone) on CD95 T helper human lymphocytes.


[Intracellular and intercellular signal transduction pathways and age alterations of proliferative activity and apoptosis intensity in cells of immune system].


Age-dependent modifications of Type 1 and Type 2 cytokines within virgin and memory CD4 T cells in humans.


Age dependency and mutual relations in T and B lymphocyte abnormalities in common variable immunodeficiency patients.


Age-related changes in cell surface and senescence markers in the spleen of DBA/2 mice: a flow cytometric analysis.


Accumulation of memory T cells from childhood to old age: central and effector memory cells in CD4( ) versus effector memory and terminally differentiated memory cells in CD8( ) compartment.


CD8 T-cell immune phenotype of successful aging.


Differential role of lipid rafts in the functions of CD4 and CD8 human T lymphocytes with aging.


Age-related differences in phenotype and function of CD4 T cells are due to a phenotypic shift from naive to memory effector CD4 T cells.


Vitamin E and gene expression in immune cells.


Long-term cytomegalovirus infection leads to significant changes in the composition of the CD8 T-cell repertoire, which may be the basis for an imbalance in the cytokine production profile in elderly persons.


T cell subsets and mortality in older community-dwelling women.


Phenotypic and functional characterization of CD4 T cells expressing killer Ig-like receptors.


CD28 activation does not down-regulate Cbl-b expression in aged rat T-lymphocytes.


Age associated alterations in costimulatory and adhesion molecule expression in lupus-prone mice are attenuated by food restriction with n-6 and n-3 fatty acids.


Different contribution of EBV and CMV infections in very long-term carriers to age-related alterations of CD8 T cells.


T cell replicative senescence: pleiotropic effects on human aging.


Engineering anticancer T cells for extended functional longevity.


No intrinsic deficiencies in CD8 T cell-mediated antitumor immunity with aging.


Significant presence of terminally differentiated T cells and altered NF-kappaB and I-kappaBalpha interactions in healthy ageing.


Activation marker expression and apoptotic susceptibility of T-cell clones derived from CD34( ), young and SENIEUR donors.


Replicative senescence of CD8 T cells: effect on human ageing.


Proliferation and apoptosis of human CD8( )CD28( ) and CD8( )CD28(-) lymphocytes during aging.


Paradoxical age-related cell cycle quickening of human CD4( ) lymphocytes: a role for cyclin D1 and calpain.


Immune consequences of the spontaneous pro-inflammatory status in depressed elderly patients.


CD7 and CD28 are required for murine CD4 CD25 regulatory T cell homeostasis and prevention of thyroiditis.


In vitro senescence of immune cells.


Antigen-independent expansion of CD28hi CD8 cells from aged mice: cytokine requirements and signal transduction pathways.


FasL-induced downregulation of CD28 expression on jurkat cells in vitro is associated with activation of caspases.


Immunophenotyping and T-cell proliferative capacity in a healthy aged population.


Hydrogen peroxide induced down-regulation of CD28 expression of Jurkat cells is associated with a change of site alpha-specific nuclear factor binding activity and the activation of caspase-3.


Marked increase with age of type 1 cytokines within memory and effector/cytotoxic CD8 T cells in humans: a contribution to understand the relationship between inflammation and immunosenescence.


Lymphocyte modulation in a baboon model of immunosenescence.


Large numbers of dysfunctional CD8 T lymphocytes bearing receptors for a single dominant CMV epitope in the very old.


Immunosenescence, autoimmunity, and rheumatoid arthritis.


Identifying the MAGUK protein Carma-1 as a central regulator of humoral immune responses and atopy by genome-wide mouse mutagenesis.


Age-related immune dysfunction in health and in human immunodeficiency virus (HIV) disease: association of age and HIV infection with naive CD8 cell depletion, reduced expression of CD28 on CD8 cells, and reduced thymic volumes.


Age-related increase of peripheral CD4 CD8 double-positive T lymphocytes in cynomolgus monkeys: longitudinal study in relation to thymic involution.


Changes in the expression of CD31 and CXCR3 in CD4 naïve T cells in elderly persons.


Proliferation of CD8 in culture of human T cells derived from peripheral blood of adult donors and cord blood of newborns.


Telomere length measurement and determination of immunosenescence-related markers (CD28, CD45RO, CD45RA, interferon-gamma and interleukin-4) in skin-homing T cells expressing the cutaneous lymphocyte antigen: indication of a non-ageing T-cell subset.


Compromised interferon gamma (IFN-gamma) production in the elderly to both acute and latent viral antigen stimulation: contribution to the immune risk phenotype?


IL-4-producing CD8 T cells with a CD62L (bright) phenotype accumulate in a subgroup of older adults and are associated with the maintenance of intact humoral immunity in old age.


[Modification of the immune response in the elderly with nutritional treatments].


APC-dependent impairment of T cell proliferation in aging: role of CD28- and IL-12/IL-15-mediated signaling.


CTLA-4 upregulation during aging.


A subset of CD8 memory T cells from old mice have high levels of CD28 and produce IFN-gamma.


Effects of ageing on the immunoregulation of parasitic infection.


Expression of CD28 by bone marrow stromal cells and its involvement in B lymphopoiesis.


Reduced CTLA-4 protein and messenger RNA expression in umbilical cord blood T lymphocytes.


Age-associated decrease in virus-specific CD8 T lymphocytes during primary influenza infection.


Lower percentage of CD8(high )CD152( ) but not CD8(high )CD28( ) T lymphocytes in the elderly may be reverted by interleukin 2 in vitro.


Molecular mechanisms for gender differences in susceptibility to T cell-mediated autoimmune diabetes in nonobese diabetic mice.


Age-related telomere length dynamics in peripheral blood mononuclear cells of healthy cynomolgus monkeys measured by Flow FISH.


Age associated decline in CD25 and CD28 expression correlate with an increased susceptibility to CD95 mediated apoptosis in T cells.


Expansions of peripheral blood CD8 T-lymphocyte subpopulations and an association with cytomegalovirus seropositivity in the elderly: the Swedish NONA immune study.


Ubiquitin-proteasome pathway is compromised in CD45RO and CD45RA T lymphocyte subsets during aging.


HIV infection and aging: enhanced Interferon- and Tumor Necrosis Factor-alpha production by the CD8 CD28- T subset.


Down-regulation of CD28 expression by TNF-alpha.


The developing human immune system: T-cell receptor repertoire of children and young adults shows a wide discrepancy in the frequency of persistent oligoclonal T-cell expansions.


Increased expression of NK cell markers on T lymphocytes in aging and chronic activation of the immune system reflects the accumulation of effector/senescent T cells.


Cellular restoration in HIV infected persons treated with abacavir and a protease inhibitor: age inversely predicts naive CD4 cell count increase.


Response differences between human CD4( ) and CD8( ) T-cells during CD28 costimulation: implications for immune cell-based therapies and studies related to the expansion of double-positive T-cells during aging.


Age-associated changes in interferon-gamma and interleukin-4 secretion by purified human CD4 and CD8 T cells.


Distinct categories of immunologic changes in frail elderly.


Altered Th1/Th2 commitment in human CD4 T cells with ageing.


Shortage of circulating naive CD8( ) T cells provides new insights on immunodeficiency in aging.


Costimulatory mechanisms in the elderly.


Age-related decline in activation of JNK by TCR- and CD28-mediated signals in murine T-lymphocytes.


Exercise induces recruitment of lymphocytes with an activated phenotype and short telomeres in young and elderly humans.


Age-sensitive and -insensitive pathways leading to JNK activation in mouse CD4( ) T-cells.


Aging impairs induction of cyclin-dependent kinases and down-regulation of p27 in mouse CD4( ) cells.


Age-related alteration of cytokine production profile by T cell subsets in mice: a flow cytometric study.


Functional integrity of the CD28 co-stimulatory pathway in T lymphocytes from elderly subjects.


Immune restoration does not invariably occur following long-term HIV-1 suppression during antiretroviral therapy. INCAS Study Group.


Postthymic development of CD28-CD8 T cell subset: age-associated expansion and shift from memory to naive phenotype.


Role of cytomegalovirus in the T cell changes seen in elderly individuals.


Differentiation of human CD8 T cells: implications for in vivo persistence of CD8 CD28- cytotoxic effector clones.


Age-related changes in major lymphocyte subsets in cynomolgus monkeys.


Analysis of Raf-1 activation in response to TCR activation and costimulation in murine T-lymphocytes: effect of age.


Role of mRNA stability in the different patterns of cytokine production by CD4 cells from young and old mice.


Low CD3 CD28-induced interleukin-2 production correlates with decreased reactive oxygen intermediate formation in neonatal T cells.


Functional properties of CD4 CD28- T cells in the aging immune system.


Age-dependent remodeling of peripheral blood CD4 CD8 T lymphocytes in cynomolgus monkeys.


CD28 expression in T cell aging and human longevity.


Progressive decrease of CD8high CD28 CD57- cells with ageing.


Evaluation of the age-dependent development of lymphocyte surface receptors in children.


Aging-related deficiency of CD28 expression in CD4 T cells is associated with the loss of gene-specific nuclear factor binding activity.


Immune reconstitution following T-cell depleted bone marrow transplantation: effect of age and posttransplant graft rejection prophylaxis.


T lymphocyte proliferative capability to defined stimuli and costimulatory CD28 pathway is not impaired in healthy centenarians.


Altered expression of various receptors on T cells in young and old mice after mitogenic stimulation: a flow cytometric analysis.


Evidence of enhanced type 2 immune response and impaired upregulation of a type 1 response in frail elderly nursing home residents.


Immunity aging. I. The chronic perduration of the thymus acute involution at puberty? Or the participation of the lymphoid organs and cells in fatal physiologic decline?


Cord blood CD4 CD45RA T cells achieve a lower magnitude of activation when compared with their adult counterparts.


CD72 ligation regulates defective naive newborn B cell responses.


Expansion of cytotoxic CD8 CD28- T cells in healthy ageing people, including centenarians.


Oligoclonality of CD8 T cells in health and disease: aging, infection, or immune regulation?


An age-related decrease in rescue from T cell death following costimulation mediated by CD28.


Cytokine production by T lymphocytes from young and aged mice.


Long-term culture of monoclonal human T lymphocytes: models for immunosenescence?


Age-related defects in CD2 receptor-induced activation in human T-cell subsets.


Developmental regulation of a murine T-cell-specific tyrosine kinase gene, Tsk.


Clonal populations of T cells in normal elderly humans: the T cell equivalent to "benign monoclonal gammapathy".


Age-related increase in the fraction of CD27-CD4 T cells and IL-4 production as a feature of CD4 T cell differentiation in vivo.


Increased dexamethasone sensitivity of neonatal leukocytes: different mechanisms of glucocorticoid inhibition of T cell proliferation in adult and neonatal cells.


Steroids as regulators of the mammalian immune response.


Enrichment for Th1 cells in the Mel-14 CD4 T cell fraction in aged mice.


Aged T cells are hyporesponsive to costimulation mediated by CD28.


Mel14 CD4 T cells from aged mice display functional and phenotypic characteristics of memory cells.


Characterization of a cell surface-expressed disulfide-linked dimer involved in murine T cell activation.


A novel T cell-activating molecule (THAM) highly expressed on CD4-CD8- murine thymocytes.