Aging genes 3-9

ABO

Allelic distribution of [i]ABO[/i] gene in Chinese centenarians. / 09.2020 / PubMed / Full text
Genetically Determined ABO Blood Group and its Associations With Health and Disease. / 03.2020 / PubMed / Full text
Plasma proteomic and autoantibody profiles reveal the proteomic characteristics involved in longevity families in Bama, China. / 2019 / PubMed / Full text
Recipients with blood group A associated with longer survival rates in cardiac valvular bioprostheses. / 04.2019 / PubMed / Full text
ABO blood group polymorphism has an impact on prostate, kidney and bladder cancer in association with longevity. / 07.2018 / PubMed / Full text
Aging and ABO blood type influence von Willebrand factor and factor VIII levels through interrelated mechanisms. / 05.2016 / PubMed / Full text
Genome-Wide Scan Informed by Age-Related Disease Identifies Loci for Exceptional Human Longevity. / 12.2015 / PubMed / Full text
Evolutionary aspects of ABO blood group in humans. / 15.04.2015 / PubMed / Full text
Possible role of ABO system in age-related diseases and longevity: a narrative review. / 2014 / PubMed / Full text

ACD

Genetics of cognitive trajectory in Brazilians: 15 years of follow-up from the Bambuí-Epigen Cohort Study of Aging. / 02.12.2019 / PubMed / Full text
Changes in Ocular Parameters and Intraocular Lens Powers in Aging Cycloplegic Eyes. / 01.2017 / PubMed / Full text
Biometry and visual function of a healthy cohort in Leipzig, Germany. / 07.06.2016 / PubMed / Full text
Valosin-containing protein is a key mediator between autophagic cell death and apoptosis in adult hippocampal neural stem cells following insulin withdrawal. / 22.03.2016 / PubMed / Full text
Long-term effect of orthokeratology on the anterior segment length. / 08.2016 / PubMed / Full text
Relationship between age, corneal astigmatism, and ocular dimensions with reference to astigmatism in eyes undergoing routine cataract surgery. / 04.2016 / PubMed / Full text
Iron Status and Inflammation in Early Stages of Chronic Kidney Disease. / 2015 / PubMed / Full text
Regulation of autophagic cell death by glycogen synthase kinase-3β in adult hippocampal neural stem cells following insulin withdrawal. / 19.05.2015 / PubMed / Full text
Analysis of age, refractive error and gender related changes of the cornea and the anterior segment of the eye with Scheimpflug imaging. / 10.2015 / PubMed / Full text

ADA

Adenosine Metabolism in the Cerebral Cortex from Several Mice Models during Aging. / 02.10.2020 / PubMed / Full text
Risk factors for diabetic kidney disease in adults with longstanding type 1 diabetes: results from the Canadian Study of Longevity in Diabetes. / 11.2019 / PubMed / Full text
Ideglira is Associated With Improved Short-Term Clinical Outcomes and Cost Savings Compared with Insulin Glargine U100 Plus Insulin Aspart in the U.S. / 09.2018 / PubMed / Full text
Mismatch between ADA and AGS recommendations for glycated hemoglobin targets for older adults. / 04.2018 / PubMed / Full text
Manganese(II) Chloride Alters Nucleotide and Nucleoside Catabolism in Zebrafish (Danio rerio) Adult Brain. / 05.2018 / PubMed / Full text
Analysis of Extracellular Nucleotide Metabolism in Adult Zebrafish After Embryological Exposure to Valproic Acid. / 07.2017 / PubMed / Full text
Web Accessibility for Older Adults: A Comparative Analysis of Disability Laws. / 10.2015 / PubMed / Full text
[Effect of electroacupuncture intervention on expression of testicular P 450 scc/17 β-HSD3 in rats with partial androgen deficiency]. / 02.2015 / PubMed
Effect of zinc supplementation on E-ADA activity, seric zinc, and cytokines levels of Trypanosoma evansi infected Wistar rats. / 09.2014 / PubMed / Full text

ARNT

Loss of ARNT in skeletal muscle limits muscle regeneration in aging. / 12.2020 / PubMed / Full text
[Arylhydrocarbon receptor nuclear translocator (ARNT) in human skin during aging.] / 2020 / PubMed
The E3 ubiquitin ligase STUB1 attenuates cell senescence by promoting the ubiquitination and degradation of the core circadian regulator BMAL1. / 03.04.2020 / PubMed / Full text
Deficiency of Bmal1 disrupts the diurnal rhythm of haemostasis. / 04.2019 / PubMed / Full text
Insulin-like growth factor-1 acts as a zeitgeber on hypothalamic circadian clock gene expression via glycogen synthase kinase-3β signaling. / 02.11.2018 / PubMed / Full text
Aging and chromatoid body assembly: Are these two physiological events linked? / 07.2018 / PubMed / Full text
Deficiency of circadian clock protein BMAL1 in mice results in a low bone mass phenotype. / 03.2016 / PubMed / Full text
Circadian clocks govern calorie restriction-mediated life span extension through BMAL1- and IGF-1-dependent mechanisms. / 04.2016 / PubMed / Full text
Whole blood thrombin generation in Bmal1-deficient mice. / 08.2014 / PubMed / Full text

AVP

Plasma oxytocin and vasopressin levels in young and older men and women: Functional relationships with attachment and cognition. / 12.2019 / PubMed / Full text
Pathophysiological Mechanisms of Nocturia and Nocturnal Polyuria: The Contribution of Cellular Function, the Urinary Bladder Urothelium, and Circadian Rhythm. / 11.2019 / PubMed / Full text
Neuropeptide changes in the suprachiasmatic nucleus are associated with the development of hypertension. / 08.2019 / PubMed / Full text
The effects of aging on biosynthetic processes in the rat hypothalamic osmoregulatory neuroendocrine system. / 05.2018 / PubMed / Full text
Copeptin and insulin resistance: effect modification by age and 11 β-HSD2 activity in a population-based study. / 07.2018 / PubMed / Full text
A decline in female baboon hypothalamo-pituitary-adrenal axis activity anticipates aging. / 09.05.2017 / PubMed / Full text
Hyponatremia and bone disease. / 03.2017 / PubMed / Full text
Social peptides: measuring urinary oxytocin and vasopressin in a home field study of older adults at risk for dehydration. / 11.2014 / PubMed / Full text
Renal physiology of nocturia. / 04.2014 / PubMed / Full text

BMI1

Senescence Induced by BMI1 Inhibition Is a Therapeutic Vulnerability in H3K27M-Mutant DIPG. / 20.10.2020 / PubMed / Full text
microRNA-31 inhibition partially ameliorates the deficiency of bone marrow stromal cells from cleidocranial dysplasia. / 06.2019 / PubMed / Full text
Timosaponin A-III inhibits oncogenic phenotype via regulation of PcG protein BMI1 in breast cancer cells. / 07.2018 / PubMed / Full text
Suppressing P16 and P14 pathways overcomes apoptosis in individualized human embryonic stem cells. / 03.2017 / PubMed / Full text
BMI1 inhibits senescence and enhances the immunomodulatory properties of human mesenchymal stem cells via the direct suppression of MKP-1/DUSP1. / 08.2016 / PubMed / Full text
Adipose-derived stem cells from lean and obese humans show depot specific differences in their stem cell markers, exosome contents and senescence: role of protein kinase C delta (PKCδ) in adipose stem cell niche. / 2016 / PubMed / Full text
A miR-200c/141-BMI1 autoregulatory loop regulates oncogenic activity of BMI1 in cancer cells. / 14.06.2016 / PubMed / Full text
MicroRNA-31 is a transcriptional target of histone deacetylase inhibitors and a regulator of cellular senescence. / 17.04.2015 / PubMed / Full text
PLK1 inhibition down-regulates polycomb group protein BMI1 via modulation of the miR-200c/141 cluster. / 30.01.2015 / PubMed / Full text

BNIP3

Late life maintenance and enhancement of functional exercise capacity in low and high responding rats after low intensity treadmill training. / 01.10.2019 / PubMed / Full text
Regulation of apoptosis and autophagy in mouse and human skeletal muscle with aging and lifelong exercise training. / 01.10.2018 / PubMed / Full text
Effects of β-hydroxy-β-methylbutyrate on skeletal muscle mitochondrial content and dynamics, and lipids after 10 days of bed rest in older adults. / 01.11.2017 / PubMed / Full text
Akt2 ablation prolongs life span and improves myocardial contractile function with adaptive cardiac remodeling: role of Sirt1-mediated autophagy regulation. / 10.2017 / PubMed / Full text
In Brief: Mitophagy: mechanisms and role in human disease. / 11.2016 / PubMed / Full text
Mfn2 deficiency links age-related sarcopenia and impaired autophagy to activation of an adaptive mitophagy pathway. / 01.08.2016 / PubMed / Full text
Interfacing mitochondrial biogenesis and elimination to enhance host pathogen defense and longevity. / 07-09.2015 / PubMed / Full text
Coupling mitogenesis and mitophagy for longevity. / 2015 / PubMed / Full text
Dying myofibers in elderly mouse skeletal muscles are characterized by the appearance of dystrophin-encircled vacuoles. / 08.2015 / PubMed / Full text

CBS

Permanent cystathionine-β-Synthase gene knockdown promotes inflammation and oxidative stress in immortalized human adipose-derived mesenchymal stem cells, enhancing their adipogenic capacity. / 02.08.2020 / PubMed / Full text
Cardiovascular phenotype of mice lacking 3-mercaptopyruvate sulfurtransferase. / 06.2020 / PubMed / Full text
Methionine restriction leads to hyperhomocysteinemia and alters hepatic H S production capacity in Fischer-344 rats. / 12.2018 / PubMed / Full text
Human Cord Blood Serum-Derived APP α-Secretase Cleavage Activity is Mediated by C1 Complement. / 04.2018 / PubMed / Full text
Dietary and Endocrine Regulation of Endogenous Hydrogen Sulfide Production: Implications for Longevity. / 01.06.2018 / PubMed / Full text
Nitration-mediated deficiency of cystathionine β-synthase activity accelerates the progression of hyperhomocysteinemia. / 12.2017 / PubMed / Full text
Standing sagittal alignment of the whole axial skeleton with reference to the gravity line in humans. / 05.2017 / PubMed / Full text
Hydrogen sulfide mediates the protection of dietary restriction against renal senescence in aged F344 rats. / 26.07.2016 / PubMed / Full text
Hippocampal cystathionine beta synthase in young and aged mice. / 20.03.2014 / PubMed / Full text

CD24

CD24 expression indicates healthier phenotype and less tendency of cellular senescence in human nucleus pulposus cells. / 12.2019 / PubMed / Full text
Innate and adaptive immune dysregulation in critically ill ICU patients. / 05.07.2018 / PubMed / Full text
Some chemotherapeutics-treated colon cancer cells display a specific phenotype being a combination of stem-like and senescent cell features. / 02.01.2018 / PubMed / Full text
Notochordal and nucleus pulposus marker expression is maintained by sub-populations of adult human nucleus pulposus cells through aging and degeneration. / 04.05.2017 / PubMed / Full text
Senescence-associated IL-6 and IL-8 cytokines induce a self- and cross-reinforced senescence/inflammatory milieu strengthening tumorigenic capabilities in the MCF-7 breast cancer cell line. / 04.05.2017 / PubMed / Full text
CD24 enrichment protects while its loss increases susceptibility of juvenile chondrocytes towards inflammation. / 12.12.2016 / PubMed / Full text
Identifying molecular phenotype of nucleus pulposus cells in human intervertebral disc with aging and degeneration. / 08.2016 / PubMed / Full text
Loss of CD24 in Mice Leads to Metabolic Dysfunctions and a Reduction in White Adipocyte Tissue. / 2015 / PubMed / Full text
Similar ex vivo expansion and post-irradiation regenerative potential of juvenile and aged salivary gland stem cells. / 09.2015 / PubMed / Full text

CD33

Maximum reproductive lifespan correlates with CD33rSIGLEC gene number: Implications for NADPH oxidase-derived reactive oxygen species in aging. / 02.2020 / PubMed / Full text
New genetic players in late-onset Alzheimer's disease: Findings of genome-wide association studies. / 08.2018 / PubMed / Full text
Chromogenic Multiplex Immunohistochemistry Reveals Modulation of the Immune Microenvironment Associated with Survival in Elderly Patients with Lung Adenocarcinoma. / 13.09.2018 / PubMed / Full text
Recent studies on cellular and molecular mechanisms in Alzheimer's disease: focus on epigenetic factors and histone deacetylase. / 28.03.2018 / PubMed / Full text
Association and interaction effects of Alzheimer's disease-associated genes and lifestyle on cognitive aging in older adults in a Taiwanese population. / 11.04.2017 / PubMed / Full text
Gene-based aggregate SNP associations between candidate AD genes and cognitive decline. / 04.2016 / PubMed / Full text
Impacts of CD33 Genetic Variations on the Atrophy Rates of Hippocampus and Parahippocampal Gyrus in Normal Aging and Mild Cognitive Impairment. / 03.2017 / PubMed / Full text
Human-specific derived alleles of CD33 and other genes protect against postreproductive cognitive decline. / 05.01.2016 / PubMed / Full text
Siglec receptors impact mammalian lifespan by modulating oxidative stress. / 07.04.2015 / PubMed / Full text

CXCL8

Cerebrovascular Senescence Is Associated With Tau Pathology in Alzheimer's Disease. / 2020 / PubMed / Full text
Age-related pro-inflammatory and pro-angiogenic changes in human aqueous humor. / 2018 / PubMed / Full text
Immune senescence and biomarkers profile of Bambuí aged population-based cohort. / 03.2018 / PubMed / Full text
Predictive value of multiple cytokines and chemokines for mortality in an admixed population: 15-year follow-up of the Bambui-Epigen (Brazil) cohort study of aging. / 11.2017 / PubMed / Full text
Gemcitabine induces cell senescence in human pancreatic cancer cell lines. / 26.08.2016 / PubMed / Full text
In vitro cytokine induction by TLR-activating vaccine adjuvants in human blood varies by age and adjuvant. / 07.2016 / PubMed / Full text
Senescent peritoneal mesothelium induces a pro-angiogenic phenotype in ovarian cancer cells in vitro and in a mouse xenograft model in vivo. / 01.2016 / PubMed / Full text
Colorectal cancer-promoting activity of the senescent peritoneal mesothelium. / 06.10.2015 / PubMed / Full text
CCL2, CXCL8, CXCL9 and CXCL10 serum levels increase with age but are not altered by treatment with hydroxychloroquine in patients with osteoarthritis of the knees. / 12.2017 / PubMed / Full text

CXCR2

CXCL5-CXCR2 signaling is a senescence-associated secretory phenotype in preimplantation embryos. / 10.2020 / PubMed / Full text
Senescence in Wound Repair: Emerging Strategies to Target Chronic Healing Wounds. / 2020 / PubMed / Full text
Cellular Senescence in Diabetic Wounds: When Too Many Retirees Stress the System. / 05.2019 / PubMed / Full text
Elevated Local Senescence in Diabetic Wound Healing Is Linked to Pathological Repair via CXCR2. / 05.2019 / PubMed / Full text
A Neutrophil Timer Coordinates Immune Defense and Vascular Protection. / 19.02.2019 / PubMed / Full text
Chronic Resveratrol Treatment Reduces the Pro-angiogenic Effect of Human Fibroblast "Senescent-Associated Secretory Phenotype" on Endothelial Colony-Forming Cells: The Role of IL8. / 23.04.2019 / PubMed / Full text
Knockdown of IL-8 Provoked Premature Senescence of Placenta-Derived Mesenchymal Stem Cells. / 15.06.2017 / PubMed / Full text
Habitual physical activity is associated with the maintenance of neutrophil migratory dynamics in healthy older adults. / 08.2016 / PubMed / Full text
CXCL1 Triggers Caspase-3 Dependent Tau Cleavage in Long-Term Neuronal Cultures and in the Hippocampus of Aged Mice: Implications in Alzheimer's Disease. / 2015 / PubMed / Full text

DBI

Quantifying cumulative anticholinergic and sedative drug load among US Medicare Beneficiaries. / 01.10.2020 / PubMed / Full text
Drug Burden Index and Cognitive and Physical Function in Aged Care Residents: A Longitudinal Study. / 08.2020 / PubMed / Full text
Using the Drug Burden Index to identify older adults at highest risk for medication-related falls. / 12.06.2020 / PubMed / Full text
Impact of STEADI-Rx: A Community Pharmacy-Based Fall Prevention Intervention. / 08.2020 / PubMed / Full text
Association of Drug Burden Index with grip strength, timed up and go and Barthel index activities of daily living in older adults with intellectual disabilities: an observational cross-sectional study. / 24.06.2019 / PubMed / Full text
Impact of drug burden index on adverse health outcomes in Irish community-dwelling older people: a cohort study. / 29.04.2019 / PubMed / Full text
Dietary Balance Index-07 and the Risk of Anemia in Middle Aged and Elderly People in Southwest China: A Cross Sectional Study. / 31.01.2018 / PubMed / Full text
Effects of Changes in Number of Medications and Drug Burden Index Exposure on Transitions Between Frailty States and Death: The Concord Health and Ageing in Men Project Cohort Study. / 01.2016 / PubMed / Full text
Drug Burden Index score and anticholinergic risk scale as predictors of readmission to the hospital. / 03.2014 / PubMed / Full text

DPP4

Age-Dependent Assessment of Genes Involved in Cellular Senescence, Telomere, and Mitochondrial Pathways in Human Lung Tissue of Smokers, COPD, and IPF: Associations With SARS-CoV-2 COVID-19 ACE2-TMPRSS2-Furin-DPP4 Axis. / 2020 / PubMed / Full text
Dipeptidyl peptidase-4 inhibition improves endothelial senescence by activating AMPK/SIRT1/Nrf2 signaling pathway. / 07.2020 / PubMed / Full text
Molecular crosstalk between Y5 receptor and neuropeptide Y drives liver cancer. / 01.05.2020 / PubMed / Full text
Dose rectification of an imbalance between DPP4 and GLP-1 ameliorates chronic stress-related vascular aging and atherosclerosis? / 05.2018 / PubMed / Full text
Chronic Psychological Stress Accelerates Vascular Senescence and Impairs Ischemia-Induced Neovascularization: The Role of Dipeptidyl Peptidase-4/Glucagon-Like Peptide-1-Adiponectin Axis. / 28.09.2017 / PubMed / Full text
Identification of senescent cell surface targetable protein DPP4. / 01.08.2017 / PubMed / Full text
Increased dipeptidyl peptidase-4 accelerates diet-related vascular aging and atherosclerosis in ApoE-deficient mice under chronic stress. / 15.09.2017 / PubMed / Full text
Sarcopenia in Elderly Diabetic Patients: Role of Dipeptidyl Peptidase 4 Inhibitors. / 01.10.2016 / PubMed / Full text
Teneligliptin improves metabolic abnormalities in a mouse model of postmenopausal obesity. / 10.2015 / PubMed / Full text

FNDC5

Irisin Correlates Positively With BMD in a Cohort of Older Adult Patients and Downregulates the Senescent Marker p21 in Osteoblasts. / 14.10.2020 / PubMed / Full text
[Investigation of signal molecules in saliva: prospects of application for diagnostics of myocardial infarction and the aging rate of different age people.] / 2019 / PubMed
Mechanistic complexities of bone loss in Alzheimer's disease: a review. / 01.2020 / PubMed / Full text
Towards frailty biomarkers: Candidates from genes and pathways regulated in aging and age-related diseases. / 11.2018 / PubMed / Full text
Exercise Training Protects Against Aging-Induced Cognitive Dysfunction via Activation of the Hippocampal PGC-1α/FNDC5/BDNF Pathway. / 09.2018 / PubMed / Full text
Epistasis, physical capacity-related genes and exceptional longevity: FNDC5 gene interactions with candidate genes FOXOA3 and APOE. / 14.11.2017 / PubMed / Full text
Exercise increases mitochondrial complex I activity and DRP1 expression in the brains of aged mice. / 04.2017 / PubMed / Full text
Irisin-encoding gene (FNDC5) variant is associated with changes in blood pressure and lipid profile in type 2 diabetic women but not in men. / 09.2015 / PubMed / Full text
FNDC5 (irisin) gene and exceptional longevity: a functional replication study with rs16835198 and rs726344 SNPs. / 2014 / PubMed / Full text

FOXM1

Sirtuin 6 deficiency induces endothelial cell senescence via downregulation of forkhead box M1 expression. / 10.11.2020 / PubMed / Full text
Upregulation of FOXM1 leads to diminished drug sensitivity in myeloma. / 21.11.2018 / PubMed / Full text
Preclinical characterization of abemaciclib in hormone receptor positive breast cancer. / 19.09.2017 / PubMed / Full text
Age-dependent human β cell proliferation induced by glucagon-like peptide 1 and calcineurin signaling. / 02.10.2017 / PubMed / Full text
FOXM1 regulates proliferation, senescence and oxidative stress in keratinocytes and cancer cells. / 07.2016 / PubMed / Full text
MELK-T1, a small-molecule inhibitor of protein kinase MELK, decreases DNA-damage tolerance in proliferating cancer cells. / 02.10.2015 / PubMed / Full text
Increased FOXM1 expression can stimulate DNA repair in normal hepatocytes in vivo but also increases nuclear foci associated with senescence. / 02.2015 / PubMed / Full text
Cellular senescence and aging: the role of B-MYB. / 10.2014 / PubMed / Full text
MiR-506 suppresses proliferation and induces senescence by directly targeting the CDK4/6-FOXM1 axis in ovarian cancer. / 07.2014 / PubMed / Full text

GSS

Geriatric brain tumor management part I: Meningioma. / 09.2019 / PubMed / Full text
Link between cardiac function and the antioxidative defense mechanism in aged rats. / 11.06.2019 / PubMed / Full text
Towards improving sterile insect technique: Exposure to orange oil compounds increases sexual signalling and longevity in Ceratitis capitata males of the Vienna 8 GSS. / 2017 / PubMed / Full text
Age-dependent changes of the antioxidant system in rat livers are accompanied by altered MAPK activation and a decline in motor signaling. / 2015 / PubMed / Full text
Comparison of Anastrepha ludens (Diptera: Tephritidae) Bisexual and Genetic Sexing (Tapachula-7) Strains: Effect of Hypoxia, Fly Density, Chilling Period, and Food Type on Fly Quality. / 04.2016 / PubMed / Full text
The Geriatric Scoring System (GSS) for Risk Stratification in Meningioma Patients as a Predictor of Outcome in Patients Treated with Radiosurgery. / 03.2016 / PubMed / Full text
'Start to finish trans-institutional transdisciplinary care': a novel approach improves colorectal surgical results in frail elderly patients. / 01.2016 / PubMed / Full text
Combined inhibitory effects of low temperature and N-acetyl-l-cysteine on the postovulatory aging of mouse oocytes. / 04.2016 / PubMed / Full text
Aging alters circadian regulation of redox in Drosophila. / 2015 / PubMed / Full text

ICOS

The Regulatory Status Adopted by Lymph Node Dendritic Cells and T Cells During Healthy Aging Is Maintained During Cancer and May Contribute to Reduced Responses to Immunotherapy. / 2018 / PubMed / Full text
End-stage renal disease, dialysis, kidney transplantation and their impact on CD4 T-cell differentiation. / 10.2018 / PubMed / Full text
Characterization of Blimp-1 function in effector regulatory T cells. / 07.2018 / PubMed / Full text
Functional exhaustion of CD4 T cells induced by co-stimulatory signals from myeloid leukaemia cells. / 12.2016 / PubMed / Full text
Development of a novel monoclonal antibody to human inducible co-stimulator ligand (ICOSL): Biological characteristics and application for enzyme-linked immunosorbent assay. / 07.2016 / PubMed / Full text
Defective TFH Cell Function and Increased TFR Cells Contribute to Defective Antibody Production in Aging. / 14.07.2015 / PubMed / Full text
IL-6 and ICOS Antagonize Bim and Promote Regulatory T Cell Accrual with Age. / 01.08.2015 / PubMed / Full text
Interleukin-33 and Interferon-γ Counter-Regulate Group 2 Innate Lymphoid Cell Activation during Immune Perturbation. / 21.07.2015 / PubMed / Full text
Circulating CXCR5 PD-1 response predicts influenza vaccine antibody responses in young adults but not elderly adults. / 01.10.2014 / PubMed / Full text

IL1B

Aged marrow macrophages expand platelet-biased hematopoietic stem cells via Interleukin1B. / 18.04.2019 / PubMed / Full text
MEF2A alters the proliferation, inflammation-related gene expression profiles and its silencing induces cellular senescence in human coronary endothelial cells. / 18.03.2019 / PubMed / Full text
Measuring the Inflammasome in Oncogene-Induced Senescence. / 2019 / PubMed / Full text
Lower levels of interleukin-1β gene expression are associated with impaired Langerhans' cell migration in aged human skin. / 01.2018 / PubMed / Full text
Age-dependent changes in inflammation and extracellular matrix in bovine oviduct epithelial cells during the post-ovulatory phase. / 09.2016 / PubMed / Full text
Differential Matrix Metalloprotease (MMP) Expression Profiles Found in Aged Gingiva. / 2016 / PubMed / Full text
Gene expression of inflammasome components in peripheral blood mononuclear cells (PBMC) of vascular patients increases with age. / 2015 / PubMed / Full text
Gene expression markers of age-related inflammation in two human cohorts. / 10.2015 / PubMed / Full text
Prior infection exacerbates postoperative cognitive dysfunction in aged rats. / 15.07.2015 / PubMed / Full text

LSS

Surgical results in older patients with lumbar spinal stenosis according to gait speed in relation to the diagnosis for sarcopenia. / 01-04.2020 / PubMed / Full text
Streamlining an existing hip fracture patient pathway in an acute tertiary adult Irish hospital to improve patient experience and outcomes. / 22.12.2019 / PubMed / Full text
Low-dose radiation from A-bombs elongated lifespan and reduced cancer mortality relative to un-irradiated individuals. / 2018 / PubMed / Full text
Lung, Laryngeal and Other Respiratory Cancer Incidence among Japanese Atomic Bomb Survivors: An Updated Analysis from 1958 through 2009. / 05.2017 / PubMed / Full text
Quantitating the lateral skin stiffness by a new and versatile electro-mechanical instrument. Preliminary studies. / 08.2017 / PubMed / Full text
A message to Fukushima: nothing to fear but fear itself. / 2016 / PubMed / Full text
Exposure to ionizing radiation and brain cancer incidence: The Life Span Study cohort. / 06.2016 / PubMed / Full text
Lumbar spondylosis, lumbar spinal stenosis, knee pain, back muscle strength are associated with the locomotive syndrome: Rural population study in Japan. / 05.2016 / PubMed / Full text
Does Obesity Affect Outcomes After Decompressive Surgery for Lumbar Spinal Stenosis? A Multicenter, Observational, Registry-Based Study. / 11.2015 / PubMed / Full text

MGMT

Cytotoxic and Senolytic Effects of Methadone in Combination with Temozolomide in Glioblastoma Cells. / 23.09.2020 / PubMed / Full text
Profound, durable and MGMT-independent sensitivity of glioblastoma cells to cyclin-dependent kinase inhibition. / 01.07.2019 / PubMed / Full text
Influence of aging in the modulation of epigenetic biomarkers of carcinogenesis after exposure to air pollution. / 09.2018 / PubMed / Full text
Integrated study on comparative transcriptome and skeletal muscle function in aged rats. / 01.2018 / PubMed / Full text
Proteomics and metabolomics identify molecular mechanisms of aging potentially predisposing for chronic lymphocytic leukemia. / 02.2018 / PubMed / Full text
mTOR regulates the expression of DNA damage response enzymes in long-lived Snell dwarf, GHRKO, and PAPPA-KO mice. / 02.2017 / PubMed / Full text
GBM-associated mutations and altered protein expression are more common in young patients. / 25.10.2016 / PubMed / Full text
Ursolic acid attenuates temozolomide resistance in glioblastoma cells by downregulating O(6)-methylguanine-DNA methyltransferase (MGMT) expression. / 2016 / PubMed / Full text
Expression and methylation of DNA repair genes in lens epithelium cells of age-related cataract. / 08-09.2014 / PubMed / Full text

MIF

Mitochondrial DNA alterations in aged macrophage migration inhibitory factor-knockout mice. / 09.2019 / PubMed / Full text
Macrophage migration inhibitory factor knockdown inhibit viability and induce apoptosis of PVM/Ms. / 12.2017 / PubMed / Full text
Endogenous macrophage migration inhibitory factor reduces the accumulation and toxicity of misfolded SOD1 in a mouse model of ALS. / 06.09.2016 / PubMed / Full text
Macrophage Migration Inhibitory Factor (MIF) Deficiency Exacerbates Aging-Induced Cardiac Remodeling and Dysfunction Despite Improved Inflammation: Role of Autophagy Regulation. / 04.03.2016 / PubMed / Full text
Age-dependent alterations in the inflammatory response to pulmonary challenge. / 12.2015 / PubMed / Full text
Role of macrophage migration inhibitory factor in age-related lung disease. / 01.07.2015 / PubMed / Full text
Macrophage migration inhibitory factor confers resistance to senescence through CD74-dependent AMPK-FOXO3a signaling in mesenchymal stem cells. / 22.04.2015 / PubMed / Full text
Role of macrophage migration inhibitory factor in age-related hearing loss. / 24.10.2014 / PubMed / Full text
Macrophage migration inhibitory factor deficiency in chronic obstructive pulmonary disease. / 15.03.2014 / PubMed / Full text

MMP13

Aging aggravates intervertebral disc degeneration by regulating transcription factors toward chondrogenesis. / 02.2020 / PubMed / Full text
EGR1 promotes the cartilage degeneration and hypertrophy by activating the Krüppel-like factor 5 and β-catenin signaling. / 01.09.2019 / PubMed / Full text
Chondrocyte-Specific RUNX2 Overexpression Accelerates Post-traumatic Osteoarthritis Progression in Adult Mice. / 09.2019 / PubMed / Full text
TGF-β type 2 receptor-mediated modulation of the IL-36 family can be therapeutically targeted in osteoarthritis. / 08.05.2019 / PubMed / Full text
Systemic clearance of p16 -positive senescent cells mitigates age-associated intervertebral disc degeneration. / 06.2019 / PubMed / Full text
Design, cyclization, and optimization of MMP13-TIMP1 interaction-derived self-inhibitory peptides against chondrocyte senescence in osteoarthritis. / 01.2019 / PubMed / Full text
Overexpression of microRNA-1470 promotes proliferation and migration, and inhibits senescence of esophageal squamous carcinoma cells. / 12.2017 / PubMed / Full text
Endoplasmic reticulum stress participates in the progress of senescence and apoptosis of osteoarthritis chondrocytes. / 16.09.2017 / PubMed / Full text
Differential Matrix Metalloprotease (MMP) Expression Profiles Found in Aged Gingiva. / 2016 / PubMed / Full text

MSTN

Age- and stage-dependent variations of muscle-specific gene expression in brown trout Salmo trutta L. / 09.2017 / PubMed / Full text
Activity of metabolic enzymes and muscle-specific gene expression in parr and smolts Atlantic salmon Salmo salar L. of different age groups. / 08.2017 / PubMed / Full text
miR-30e is negatively regulated by myostatin in skeletal muscle and is functionally related to fiber-type composition. / 01.05.2017 / PubMed / Full text
Muscle-Related Polymorphisms (MSTN rs1805086 and ACTN3 rs1815739) Are Not Associated with Exceptional Longevity in Japanese Centenarians. / 2016 / PubMed / Full text
Temporal and spatial expression of Smads and their correlation with YAP1 expression in sheep. / 26.08.2016 / PubMed / Full text
Quantification of GDF11 and Myostatin in Human Aging and Cardiovascular Disease. / 14.06.2016 / PubMed / Full text
Morphological analysis and muscle-associated gene expression during different muscle growth phases of Megalobrama amblycephala. / 28.09.2015 / PubMed / Full text
The effect of exercise mode on the acute response of satellite cells in old men. / 12.2015 / PubMed / Full text
Haploinsufficiency of myostatin protects against aging-related declines in muscle function and enhances the longevity of mice. / 08.2015 / PubMed / Full text

PER2

NAD Controls Circadian Reprogramming through PER2 Nuclear Translocation to Counter Aging. / 04.06.2020 / PubMed / Full text
The protective effect of cycloastragenol on aging mouse circadian rhythmic disorder induced by d-galactose. / 10.2019 / PubMed / Full text
Investigating circadian clock gene expression in human tendon biopsies from acute exercise and immobilization studies. / 06.2019 / PubMed / Full text
Is the aging human ovary still ticking?: Expression of clock-genes in luteinized granulosa cells of young and older women. / 21.11.2018 / PubMed / Full text
Ontogeny of Circadian Rhythms and Synchrony in the Suprachiasmatic Nucleus. / 07.02.2018 / PubMed / Full text
Differential menopause- versus aging-induced changes in oxidative stress and circadian rhythm gene markers. / 06.2017 / PubMed / Full text
Negative reciprocal regulation between Sirt1 and Per2 modulates the circadian clock and aging. / 27.06.2016 / PubMed / Full text
Circadian Clock Control by Polyamine Levels through a Mechanism that Declines with Age. / 03.11.2015 / PubMed / Full text
Local receptors as novel regulators for peripheral clock expression. / 11.2014 / PubMed / Full text

SMAD3

Sirtuin 6 deficiency transcriptionally up-regulates TGF-β signaling and induces fibrosis in mice. / 10.01.2020 / PubMed / Full text
Restoring extracellular matrix synthesis in senescent stem cells. / 10.2019 / PubMed / Full text
Chromatin remodeling factor BAZ1A regulates cellular senescence in both cancer and normal cells. / 15.07.2019 / PubMed / Full text
Histopathological and molecular analysis of idiopathic pulmonary fibrosis lungs from patients treated with pirfenidone or nintedanib. / 01.2019 / PubMed / Full text
Beta-Catenin and SMAD3 Are Associated with Skeletal Muscle Aging in the Taurine Transpoeter Knockout Mouse. / 2017 / PubMed / Full text
STAT3-mediated SMAD3 activation underlies Oncostatin M-induced Senescence. / 16.02.2017 / PubMed / Full text
Sirtuin 3 Deregulation Promotes Pulmonary Fibrosis. / 01.05.2017 / PubMed / Full text
Circulating Growth Differentiation Factor 11/8 Levels Decline With Age. / 08.01.2016 / PubMed / Full text
Effects of aging on cardiac extracellular matrix in men and women. / 01.2016 / PubMed / Full text

SON

Absence of axonal sprouting following unilateral lesion in 125-day-old rat supraoptic nucleus may be due to age-dependent decrease in protein levels of ciliary neurotrophic factor receptor alpha. / 01.10.2019 / PubMed / Full text
Neural Mechanisms Involved in the Noxious Physical Stress-Induced Inhibition of Ovarian Estradiol Secretion. / 06.2019 / PubMed / Full text
Aging affects isoproterenol-induced water drinking, astrocyte density, and central neuronal activation in female Brown Norway rats. / 01.08.2018 / PubMed / Full text
The effects of aging on biosynthetic processes in the rat hypothalamic osmoregulatory neuroendocrine system. / 05.2018 / PubMed / Full text
Increased oxytocin-monomeric red fluorescent protein 1 fluorescent intensity with urocortin-like immunoreactivity in the hypothalamo-neurohypophysial system of aged transgenic rats. / 03.2018 / PubMed / Full text
Age-Related (Aged vs. Adult) Comparison of the Effect of Two Mild Stressors on the Nerve Growth Factor (NGF) in the Rat Hypothalamic Supraoptic Nucleus (SON) - Immunohistochemical Study. / 2016 / PubMed
Exposure to mild stress and brain derived neurotrophin factor (BDNF) immunoreactivity in the hypothalamic paraventricular (PVN) and supraoptic (SON) nuclei: Comparison between aged and adult rats. / 12.2016 / PubMed / Full text
Testing the critical window of estradiol replacement on gene expression of vasopressin, oxytocin, and their receptors, in the hypothalamus of aging female rats. / 05.01.2016 / PubMed / Full text
[Lamellar complex changes in the human basal forebrain and hypothalamic nuclei neurons in different age groups]. / 2014 / PubMed

SORL1

A candidate gene study of risk for dementia in older, postmenopausal women: Results from the Women's Health Initiative Memory Study. / 05.2019 / PubMed / Full text
Genetic Risk for Age-Related Cognitive Impairment Does Not Predict Cognitive Performance in Middle Age. / 2018 / PubMed / Full text
Genetic epistasis regulates amyloid deposition in resilient aging. / 10.2017 / PubMed / Full text
Association and interaction effects of Alzheimer's disease-associated genes and lifestyle on cognitive aging in older adults in a Taiwanese population. / 11.04.2017 / PubMed / Full text
SORL1 rs1699102 polymorphism modulates age-related cognitive decline and gray matter volume reduction in non-demented individuals. / 01.2017 / PubMed / Full text
Sex-specific characterization and evaluation of the Alzheimer's disease genetic risk factor sorl1 in zebrafish during aging and in the adult brain following a 100 ppb embryonic lead exposure. / 04.2017 / PubMed / Full text
Impact of SORL1 genetic variations on MRI markers in non-demented elders. / 31.05.2016 / PubMed / Full text
Effect of Alzheimer's Disease Risk Variant rs3824968 at SORL1 on Regional Gray Matter Volume and Age-Related Interaction in Adult Lifespan. / 21.03.2016 / PubMed / Full text
Gene-based aggregate SNP associations between candidate AD genes and cognitive decline. / 04.2016 / PubMed / Full text

TAZ

Transcriptional Coactivator TAZ Negatively Regulates Tumor Suppressor p53 Activity and Cellular Senescence. / 09.01.2020 / PubMed / Full text
Downregulation of miR-125b promotes resistance of glioma cells to TRAIL through overexpression of Tafazzin which is a mitochondrial protein. / 05.05.2019 / PubMed / Full text
Dysregulation of the Hippo pathway signaling in aging and cancer. / 05.2019 / PubMed / Full text
Long noncoding RNA Bmncr regulates mesenchymal stem cell fate during skeletal aging. / 03.12.2018 / PubMed / Full text
PGC-1α Controls Skeletal Stem Cell Fate and Bone-Fat Balance in Osteoporosis and Skeletal Aging by Inducing TAZ. / 02.08.2018 / PubMed / Full text
Transcriptional coactivator with PDZ-binding motif is required to sustain testicular function on aging. / 10.2017 / PubMed / Full text
Mutant p53 Protein and the Hippo Transducers YAP and TAZ: A Critical Oncogenic Node in Human Cancers. / 03.05.2017 / PubMed / Full text
Snail/Slug-YAP/TAZ complexes cooperatively regulate mesenchymal stem cell function and bone formation. / 04.03.2017 / PubMed / Full text
Decreased osteogenesis in mesenchymal stem cells derived from the aged mouse is associated with enhanced NF-κB activity. / 02.2017 / PubMed / Full text

TLR7

Bovine Lactoferrin Enhances TLR7-Mediated Responses in Plasmacytoid Dendritic Cells in Elderly Women: Results From a Nutritional Intervention Study With Bovine Lactoferrin, GOS and Vitamin D. / 2018 / PubMed / Full text
B cell responses to apoptotic cells in MFG-E8-/- mice. / 2018 / PubMed / Full text
Small RNAs induce the activation of the pro-inflammatory TLR7 signaling pathway in aged rat kidney. / 10.2017 / PubMed / Full text
Aging effects on T-bet expression in human B cell subsets. / 11.2017 / PubMed / Full text
Age-related changes and distribution of T cell markers (CD3 and CD4) and toll-like receptors(TLR2, TLR3,TLR4 and TLR7) in the duck lymphoid organs. / 07.2017 / PubMed / Full text
Age-associated B cells: key mediators of both protective and autoreactive humoral responses. / 01.2016 / PubMed / Full text
Aging Impairs the Ability of Conventional Dendritic Cells to Cross-Prime CD8 T Cells upon Stimulation with a TLR7 Ligand. / 2015 / PubMed / Full text
Topical treatment of basal cell carcinoma with the immune response modifier imiquimod. / 11.2015 / PubMed / Full text
Bacteria and Toll-like receptor and cytokine mRNA expression profiles associated with canine arthritis. / 15.08.2014 / PubMed / Full text

BMP4

Direct reprogramming of human smooth muscle and vascular endothelial cells reveals defects associated with aging and Hutchinson-Gilford progeria syndrome. / 08.09.2020 / PubMed / Full text
Interplay between Follistatin, Activin A, and BMP4 Signaling Regulates Postnatal Thymic Epithelial Progenitor Cell Differentiation during Aging. / 25.06.2019 / PubMed / Full text
Centenarians Overexpress Pluripotency-Related Genes. / 16.08.2019 / PubMed / Full text
BMP-SMAD-ID promotes reprogramming to pluripotency by inhibiting p16/INK4A-dependent senescence. / 15.11.2016 / PubMed / Full text
Increased bone morphogenetic protein signaling contributes to age-related declines in neurogenesis and cognition. / 02.2016 / PubMed / Full text
Control of the Normal and Pathological Development of Neural Stem and Progenitor Cells by the PC3/Tis21/Btg2 and Btg1 Genes. / 12.2015 / PubMed / Full text
FSH-FSHR3-stem cells in ovary surface epithelium: basis for adult ovarian biology, failure, aging, and cancer. / 01.2015 / PubMed / Full text
Molecular cloning and expression analysis of prostaglandin E receptor 2 gene in cashmere goat (Capra hircus) skin during hair follicle development. / 03.04.2014 / PubMed / Full text

CCL4

Microglial translational profiling reveals a convergent APOE pathway from aging, amyloid, and tau. / 03.09.2018 / PubMed / Full text
Time-Dependent Changes in Local and Serum Levels of Inflammatory Cytokines as Markers for Incised Wound Aging of Skeletal Muscles. / 05.2018 / PubMed / Full text
Human Body Composition and Immunity: Visceral Adipose Tissue Produces IL-15 and Muscle Strength Inversely Correlates with NK Cell Function in Elderly Humans. / 2018 / PubMed / Full text
Age-related pro-inflammatory and pro-angiogenic changes in human aqueous humor. / 2018 / PubMed / Full text
Age-related decline of the acute local inflammation response: a mitigating role for the adenosine A receptor. / 18.10.2017 / PubMed / Full text
Simultaneous time course analysis of multiple markers based on DNA microarray in incised wound in skeletal muscle for wound aging. / 09.2016 / PubMed / Full text
Changes in the expression of the Toll-like receptor system in the aging rat kidneys. / 2014 / PubMed / Full text
Age-related brain expression and regulation of the chemokine CCL4/MIP-1β in APP/PS1 double-transgenic mice. / 04.2014 / PubMed / Full text

CD163

Complement Inhibition Attenuates Early Erythrolysis in the Hematoma and Brain Injury in Aged Rats. / 07.2019 / PubMed / Full text
Increased monocyte activation with age among HIV-infected long term non-progressor children: implications for early treatment initiation. / 09.2019 / PubMed / Full text
Age Influences Microglial Activation After Cuprizone-Induced Demyelination. / 2018 / PubMed / Full text
Age-related M1/M2 phenotype changes in circulating monocytes from healthy/unhealthy individuals. / 08.06.2018 / PubMed / Full text
Distinct effect of age, sex, and CMV seropositivity on dendritic cells and monocytes in human blood. / 01.2018 / PubMed / Full text
Aging-related effects of bed rest followed by eccentric exercise rehabilitation on skeletal muscle macrophages and insulin sensitivity. / 01.07.2018 / PubMed / Full text
[Signal molecules of endometrium: gerontological and general pathhological aspects]. / 2015 / PubMed
Myocardial Infarction Superimposed on Aging: MMP-9 Deletion Promotes M2 Macrophage Polarization. / 04.2016 / PubMed / Full text

CD2

Adaptive NKG2C CD57 Natural Killer Cell and Tim-3 Expression During Viral Infections. / 2018 / PubMed / Full text
Genome-Wide Association Analysis of the Sense of Smell in U.S. Older Adults: Identification of Novel Risk Loci in African-Americans and European-Americans. / 12.2017 / PubMed / Full text
Tumor-host signaling interaction reveals a systemic, age-dependent splenic immune influence on tumor development. / 03.11.2015 / PubMed / Full text
Neuroimmune and Neuropathic Responses of Spinal Cord and Dorsal Root Ganglia in Middle Age. / 2015 / PubMed / Full text
Activation-induced and damage-induced cell death in aging human T cells. / 11.2015 / PubMed / Full text
White matter injury and microglia/macrophage polarization are strongly linked with age-related long-term deficits in neurological function after stroke. / 10.2015 / PubMed / Full text
The impact of immunosenescence on humoral immune response variation after influenza A/H1N1 vaccination in older subjects. / 2015 / PubMed / Full text
Therapeutic efficacy of bone marrow-derived mononuclear cells in diabetic polyneuropathy is impaired with aging or diabetes. / 03.2015 / PubMed / Full text

CD63

Cellular senescence contributes to age-dependent changes in circulating extracellular vesicle cargo and function. / 03.2020 / PubMed / Full text
Exosomal Notch3 from high glucose-stimulated endothelial cells regulates vascular smooth muscle cells calcification/aging. / 01.09.2019 / PubMed / Full text
Adiponectin promotes muscle regeneration through binding to T-cadherin. / 09.01.2019 / PubMed / Full text
Exosomes from hyperglycemia-stimulated vascular endothelial cells contain versican that regulate calcification/senescence in vascular smooth muscle cells. / 2019 / PubMed / Full text
The Aging Process Alters IL-1β and CD63 Levels Differently in Extracellular Vesicles Obtained from the Plasma and Cerebrospinal Fluid. / 2018 / PubMed / Full text
miRNA in Circulating Microvesicles as Biomarkers for Age-Related Cognitive Decline. / 2017 / PubMed / Full text
Circulating extracellular vesicles in the aging process: impact of aerobic exercise. / 03.2018 / PubMed / Full text
MicroRNA-183-5p Increases with Age in Bone-Derived Extracellular Vesicles, Suppresses Bone Marrow Stromal (Stem) Cell Proliferation, and Induces Stem Cell Senescence. / 11.2017 / PubMed / Full text

CDA

Cumulative Dis/Advantage and Health Pattern in Late Life: A Comparison between Genders and Welfare State Regimes. / 2019 / PubMed / Full text
Does numerical similarity alter age-related distractibility in working memory? / 2019 / PubMed / Full text
Can working memory capacity be expanded by boosting working memory updating efficiency in older adults? / 12.2018 / PubMed / Full text
Negative Affect Influences Electrophysiological Markers of Visual Working Memory in Mildly Stressed Older Adults. / 2018 / PubMed / Full text
EEG correlates of visual short-term memory in older age vary with adult lifespan cognitive development. / 02.2018 / PubMed / Full text
Mini dental assessment: a simple screening test for non-dental staff. / 06.2017 / PubMed / Full text
Electrophysiological Correlates of Subitizing in Healthy Aging. / 2015 / PubMed / Full text
Understanding age-related reductions in visual working memory capacity: examining the stages of change detection. / 10.2014 / PubMed / Full text

CRH

Roles of peptides and steroids in sleep disorders. / 09.2006 / PubMed / Full text
Novel molecular mechanisms for the adaptogenic effects of herbal extracts on isolated brain cells using systems biology. / 15.11.2018 / PubMed / Full text
Caenorhabditis elegans respond to high-glucose diets through a network of stress-responsive transcription factors. / 2018 / PubMed / Full text
Genome-wide association study and annotating candidate gene networks affecting age at first calving in Nellore cattle. / 12.2017 / PubMed / Full text
A C. elegans Thermosensory Circuit Regulates Longevity through crh-1/CREB-Dependent flp-6 Neuropeptide Signaling. / 24.10.2016 / PubMed / Full text
Variation in the corticotropin-releasing hormone receptor 1 (CRHR1) gene modulates age effects on working memory. / 02.2015 / PubMed / Full text
HPA axis and aging in depression: systematic review and meta-analysis. / 03.2014 / PubMed / Full text
Regulation of corticosterone secretion is modified by PFOS exposure at different levels of the hypothalamic-pituitary-adrenal axis in adult male rats. / 15.10.2014 / PubMed / Full text

CYP2C19

Physiologically Based Pharmacokinetic Approach Can Successfully Predict Pharmacokinetics of Citalopram in Different Patient Populations. / 04.2020 / PubMed / Full text
Longitudinal exposure of English primary care patients to pharmacogenomic drugs: An analysis to inform design of pre-emptive pharmacogenomic testing. / 12.2019 / PubMed / Full text
The safety, tolerability and pharmacokinetics of BI 409306, a novel and potent PDE9 inhibitor: Overview of three Phase I randomised trials in healthy volunteers. / 05.2018 / PubMed / Full text
Pediatric Cytochrome P450 Activity Alterations in Nonalcoholic Steatohepatitis. / 12.2017 / PubMed / Full text
Analysis of the variability of the pharmacokinetics of multiple drugs in young adult and elderly subjects and its implications for acceptable daily exposures and cleaning validation limits. / 06.2017 / PubMed / Full text
Determination of Human Hepatic CYP2C8 and CYP1A2 Age-Dependent Expression to Support Human Health Risk Assessment for Early Ages. / 05.2017 / PubMed / Full text
Identifying clinically relevant sources of variability: The clopidogrel challenge. / 02.2017 / PubMed / Full text
Impact of age on serum concentrations of venlafaxine and escitalopram in different CYP2D6 and CYP2C19 genotype subgroups. / 08.2014 / PubMed / Full text

DCC

X Chromosome Domain Architecture Regulates Caenorhabditis elegans Lifespan but Not Dosage Compensation. / 21.10.2019 / PubMed / Full text
Dynamic functional connectivity analysis of functional MRI based on copula time-varying correlation. / 15.07.2019 / PubMed / Full text
Comprehensive outpatient rehabilitation increases the ability of people over 60 to live independently. / 20.12.2018 / PubMed / Full text
Mesocorticolimbic Connectivity and Volumetric Alterations in [i]DCC[/i] Mutation Carriers. / 16.05.2018 / PubMed / Full text
Dcc haploinsufficiency regulates dopamine receptor expression across postnatal lifespan. / 27.03.2017 / PubMed / Full text
Potential effect of mechano growth factor E-domain peptide on axonal guidance growth in primary cultured cortical neurons of rats. / 01.2018 / PubMed / Full text
Mouse genome-wide association study identifies polymorphisms on chromosomes 4, 11, and 15 for age-related cardiac fibrosis. / 06.2016 / PubMed / Full text
Proteomic Analysis of Protein Expression Throughout Disease Progression in a Mouse Model of Alzheimer's Disease. / 2015 / PubMed / Full text

DES

Increased circulating desmosine and age-dependent elastinolysis in idiopathic pulmonary fibrosis. / 20.03.2018 / PubMed / Full text
Genetic variation in low-dose effects of neonatal DES exposure in female rats. / 10.2017 / PubMed / Full text
Aging Eye Microbiota in Dry Eye Syndrome in Patients Treated with [i]Enterococcus faecium[/i] and [i]Saccharomyces boulardii[/i]. / 2017 / PubMed / Full text
The influence of advancing age on implantation of drug-eluting stents. / 10.2016 / PubMed / Full text
Calculating when elective abdominal aortic aneurysm repair improves survival for individual patients: development of the Aneurysm Repair Decision Aid and economic evaluation. / 04.2015 / PubMed / Full text
Diethylstilbestrol exposure in neonatal mice induces changes in the adulthood in the immune response to taenia crassiceps without modifications of parasite loads. / 2014 / PubMed / Full text
Androgen deficiency and dry eye syndrome in the aging male. / 03.07.2014 / PubMed / Full text
[[[DES]] Daughter--expertise remains necessary]. / 2013 / PubMed

EDA

Interplay between aging, lung inflammation/remodeling, and fibronectin EDA in lung cancer progression. / 01.12.2020 / PubMed / Full text
Arousal Detection in Elderly People from Electrodermal Activity Using Musical Stimuli. / 25.08.2020 / PubMed / Full text
The structure of agricultural microplastics (PT, PU and UF) and their sorption capacities for PAHs and PHE derivates under various salinity and oxidation treatments. / 02.2020 / PubMed / Full text
Effect of storage on quality parameters and phenolic content of Italian extra-virgin olive oils. / 01.2020 / PubMed / Full text
Fibronectin Containing Extra Domain A Induces Plaque Destabilization in the Innominate Artery of Aged Apolipoprotein E-Deficient Mice. / 03.2018 / PubMed / Full text
An Extract from the Plant [i]Deschampsia antarctica[/i] Protects Fibroblasts from Senescence Induced by Hydrogen Peroxide. / 2017 / PubMed / Full text
Occurrence of fibronectin-fibrin complexes in plasma of patients with multimorbidity due to the inflamm-aging phenomenon. / 05.2016 / PubMed / Full text
Autonomic changes following generalized tonic clonic seizures: An analysis of adult and pediatric patients with epilepsy. / 09.2015 / PubMed / Full text

F5

Methylation signatures in peripheral blood are associated with marked age acceleration and disease progression in patients with primary sclerosing cholangitis. / 02.2020 / PubMed / Full text
Fermentation of Blackberry with [i]L. plantarum[/i] JBMI F5 Enhance the Protection Effect on UVB-Mediated Photoaging in Human Foreskin Fibroblast and Hairless Mice through Regulation of MAPK/NF-κB Signaling. / 11.10.2019 / PubMed / Full text
Proof of concept study of age-dependent DNA methylation markers across different tissues by massive parallel sequencing. / 09.2018 / PubMed / Full text
Multigenerational effects of 4-methylbenzylidene camphor (4-MBC) on the survival, development and reproduction of the marine copepod Tigriopus japonicus. / 01.2018 / PubMed / Full text
Chronological age prediction based on DNA methylation: Massive parallel sequencing and random forest regression. / 11.2017 / PubMed / Full text
Sublethal effects of imidacloprid on the fecundity, longevity, and enzyme activity of Sitobion avenae (Fabricius) and Rhopalosiphum padi (Linnaeus). / 08.2016 / PubMed / Full text
Nutritional habits, lifestyle, and genetic predisposition in cardiovascular and metabolic traits in Turkish population. / 06.2016 / PubMed / Full text
[Clinical and genetic characteristics of long-livers in Moscow region]. / 2013 / PubMed

FGFR1

Alignment of Alzheimer's disease amyloid β-peptide and klotho. / 11-12.2020 / PubMed / Full text
Satellite cell-specific ablation of Cdon impairs integrin activation, FGF signalling, and muscle regeneration. / 08.2020 / PubMed / Full text
Systemic administration of a fibroblast growth factor receptor 1 agonist rescues the cognitive deficit in aged socially isolated rats. / 06.2019 / PubMed / Full text
Impact of aging and caloric restriction on fibroblast growth factor 21 signaling in rat white adipose tissue. / 04.2019 / PubMed / Full text
Activity-dependent neuronal Klotho enhances astrocytic aerobic glycolysis. / 08.2019 / PubMed / Full text
Decline in Proliferation and Immature Neuron Markers in the Human Subependymal Zone during Aging: Relationship to EGF- and FGF-Related Transcripts. / 2016 / PubMed / Full text
Age-Related Changes in FGF-2, Fibroblast Growth Factor Receptors and β-Catenin Expression in Human Mesenchyme-Derived Progenitor Cells. / 03.2016 / PubMed / Full text
A correlation between decreased parathyroid α-Klotho and fibroblast growth factor receptor 1 expression with pathological category and parathyroid gland volume in dialysis patients. / 04.2015 / PubMed / Full text

GAA

Mitochondrial damage and senescence phenotype of cells derived from a novel frataxin G127V point mutation mouse model of Friedreich's ataxia. / 27.07.2020 / PubMed / Full text
Age-Related Changes in Serum Guanidinoacetic Acid in Women. / 30.12.2019 / PubMed / Full text
ALKB-8, a 2-Oxoglutarate-Dependent Dioxygenase and S-Adenosine Methionine-Dependent Methyltransferase Modulates Metabolic Events Linked to Lysosome-Related Organelles and Aging in C. elegans. / 2018 / PubMed
SIRT6 histone deacetylase functions as a potential oncogene in human melanoma. / 09.2017 / PubMed / Full text
Age and gender-specific reference intervals for lysosomal enzymes in dried blood spot samples: A study in Indian population. / 10.2017 / PubMed / Full text
Effects of guanidinoacetic acid diet supplementation on semen quality and fertility of broiler breeder roosters. / 02.2017 / PubMed / Full text
Effect of feeding guanidinoacetic acid and L-arginine on the fertility rate and sperm penetration in the perivitelline layer of aged broiler breeder hens. / 04.2016 / PubMed / Full text
Combined aerobic exercise and enzyme replacement therapy rejuvenates the mitochondrial-lysosomal axis and alleviates autophagic blockage in Pompe disease. / 10.2015 / PubMed / Full text

GCA

Familial aggregation of longevity in giant cell arteritis and polymyalgia rheumatica. / 12.2020 / PubMed / Full text
Interaction between Alcohol Consumption and Apolipoprotein E (ApoE) Genotype with Cognition in Middle-Aged Men. / 14.07.2020 / PubMed / Full text
Influence of young adult cognitive ability and additional education on later-life cognition. / 05.02.2019 / PubMed / Full text
Altered effective connectivity anchored in the posterior cingulate cortex and the medial prefrontal cortex in cognitively intact elderly APOE ε4 carriers: a preliminary study. / 02.2019 / PubMed / Full text
Global Cerebral Atrophy Detected by Routine Imaging: Relationship with Age, Hippocampal Atrophy, and White Matter Hyperintensities. / 05.2018 / PubMed / Full text
Evaluation and clinical correlation of practical cut-offs for visual rating scales of atrophy: normal aging versus mild cognitive impairment and Alzheimer's disease. / 09.2017 / PubMed / Full text
Neurodevelopmental origins of lifespan changes in brain and cognition. / 16.08.2016 / PubMed / Full text
Does degree of gyrification underlie the phenotypic and genetic associations between cortical surface area and cognitive ability? / 01.02.2015 / PubMed / Full text

GPI

Blood factors transfer beneficial effects of exercise on neurogenesis and cognition to the aged brain. / 10.07.2020 / PubMed / Full text
Potential role of exercise-induced glucose-6-phosphate isomerase in skeletal muscle function. / 30.06.2019 / PubMed / Full text
Red Blood Cell Homeostasis and Altered Vesicle Formation in Patients With Paroxysmal Nocturnal Hemoglobinuria. / 2019 / PubMed / Full text
Can the health of a nation be correlated to its state of internal peace? / 01-03.2016 / PubMed / Full text
Developmental role of the cell adhesion molecule Contactin-6 in the cerebral cortex and hippocampus. / 03.07.2016 / PubMed / Full text
Metabolic consequences of long-term rapamycin exposure on common marmoset monkeys (Callithrix jacchus). / 11.2015 / PubMed / Full text
Urokinase receptor and resistance to targeted anticancer agents. / 2015 / PubMed / Full text
The glycolytic enzyme, GPI, is a functionally conserved modifier of dopaminergic neurodegeneration in Parkinson's models. / 01.07.2014 / PubMed / Full text

GSTM1

The effects of everyday-life exposure to polycyclic aromatic hydrocarbons on biological age indicators. / 03.12.2020 / PubMed / Full text
Carrying the T Allele of the SNP rs574344, an eQTL of GSTM1, Contributes to Longevity in the Han Chinese Population. / 01.2019 / PubMed / Full text
Age-associated changes in GSH S-transferase gene/proteins in livers of rats. / 12.2018 / PubMed / Full text
Aging-dependent DNA hypermethylation and gene expression of GSTM1 involved in T cell differentiation. / 25.07.2017 / PubMed / Full text
[Age features of cytogenetic effects of spring-summer encephalitis among residents of northern western Siberia in connection with polymorphism for genes of glutathione-S-transferase]. / 2016 / PubMed
Lead-Related Genetic Loci, Cumulative Lead Exposure and Incident Coronary Heart Disease: The Normative Aging Study. / 2016 / PubMed / Full text
Effects of APOE rs429358, rs7412 and GSTM1/GSTT1 Polymorphism on Plasma and Erythrocyte Antioxidant Parameters and Cognition in Old Chinese Adults. / 24.09.2015 / PubMed / Full text
[Frequency of gene polymorphic variants (phase II) of biotransformation of GSTT1 and GSTM1 xenobiotics among long-livers (Precarpathian region)]. / 2013 / PubMed

HDAC2

EEF1A1 deacetylation enables transcriptional activation of remyelination. / 09.07.2020 / PubMed / Full text
Endothelial toll-like receptor 4 maintains lung integrity via epigenetic suppression of p16 . / 06.2019 / PubMed / Full text
Budesonide, Aclidinium and Formoterol in combination limit inflammaging processes in bronchial epithelial cells exposed to cigarette smoke. / 04.2019 / PubMed / Full text
HDAC3 Regulates the Transition to the Homeostatic Myelinating Schwann Cell State. / 04.12.2018 / PubMed / Full text
Altered modulation of lamin A/C-HDAC2 interaction and p21 expression during oxidative stress response in HGPS. / 10.2018 / PubMed / Full text
Histone deacetylase 1 expression is inversely correlated with age in the short-lived fish Nothobranchius furzeri. / 09.2018 / PubMed / Full text
Histone Deacetylase 2 Inhibition Attenuates Downregulation of Hippocampal Plasticity Gene Expression during Aging. / 03.2018 / PubMed / Full text
Non-sirtuin histone deacetylases in the control of cardiac aging. / 06.2015 / PubMed / Full text

IDH2

Reactive oxygen species-mediated senescence is accelerated by inhibiting Cdk2 in Idh2-deficient conditions. / 10.09.2019 / PubMed / Full text
Augmentation of cellular NAD by NQO1 enzymatic action improves age-related hearing impairment. / 10.2019 / PubMed / Full text
Improving Treatment for Myelodysplastic Syndromes Patients. / 25.10.2018 / PubMed / Full text
Loss of IDH2 Accelerates Age-related Hearing Loss in Male Mice. / 22.03.2018 / PubMed / Full text
IDH2-deficient mice develop spinal deformities with aging. / 17.07.2018 / PubMed / Full text
Idh2 deficiency accelerates renal dysfunction in aged mice. / 04.11.2017 / PubMed / Full text
IDH1 Associated with Neuronal Apoptosis in Adult Rats Brain Following Intracerebral Hemorrhage. / 07.2017 / PubMed / Full text
Epigenetic Aging Signatures Are Coherently Modified in Cancer. / 06.2015 / PubMed / Full text

LPL

Survival analyses in Holstein cows considering direct disease diagnoses and specific SNP marker effects. / 09.2020 / PubMed / Full text
Influence of common health disorders on the length of productive life and stayability in German Holstein cows. / 01.2020 / PubMed / Full text
GH prevents adipogenic differentiation of mesenchymal stromal stem cells derived from human trabecular bone via canonical Wnt signaling. / 07.2018 / PubMed / Full text
Genetic correlation and genome-wide association study (GWAS) of the length of productive life, days open, and 305-days milk yield in crossbred Holstein dairy cattle. / 29.06.2017 / PubMed / Full text
Association of Metabolic Syndrome with Serum Adipokines in Community-Living Elderly Japanese Women: Independent Association with Plasminogen Activator-Inhibitor-1. / 11.2015 / PubMed / Full text
Moderate Exercise Mitigates the Detrimental Effects of Aging on Tendon Stem Cells. / 2015 / PubMed / Full text
Association of adiponectin with serum preheparin lipoprotein lipase mass in women independent of fat mass and distribution, insulin resistance, and inflammation. / 10.2014 / PubMed / Full text
[Clinical and genetic characteristics of long-livers in Moscow region]. / 2013 / PubMed

LTA

Lipoteichoic acid from the cell wall of a heat killed Lactobacillus paracasei D3-5 ameliorates aging-related leaky gut, inflammation and improves physical and cognitive functions: from C. elegans to mice. / 02.2020 / PubMed / Full text
The change of pain classes over time: a latent transition analysis. / 02.2020 / PubMed / Full text
Leisure time activities as mediating variables in functional disability progression: An application of parallel latent growth curve modeling. / 2018 / PubMed / Full text
The Neighborhood Built Environment and Cognitive Function of Older Persons: Results from the Singapore Longitudinal Ageing Study. / 2018 / PubMed / Full text
Changes in depression among older adults in China: A latent transition analysis. / 02.2017 / PubMed / Full text
Joint effect of gene-physical activity and the interactions among CRP, TNF-α, and LTA polymorphisms on serum CRP, TNF-α levels, and handgrip strength in community-dwelling elders in Taiwan - TCHS-E. / 04.2016 / PubMed / Full text
In vitro anti-platelet potency of ticagrelor in blood samples from infants and children. / 09.2015 / PubMed / Full text
Physical Activity, Mediterranean Diet and Biomarkers-Assessed Risk of Alzheimer's: A Multi-Modality Brain Imaging Study. / 10.2014 / PubMed / Full text

MAG

Exploration of life satisfaction of Korean people with sensory impairments across the lifespan. / 10.2020 / PubMed / Full text
Omega-3 Monoacylglyceride Effects on Longevity, Mitochondrial Metabolism and Oxidative Stress: Insights from [i]Drosophila melanogaster[/i]. / 16.11.2018 / PubMed / Full text
Glial Sulfatides and Neuronal Complex Gangliosides Are Functionally Interdependent in Maintaining Myelinating Axon Integrity. / 02.01.2019 / PubMed / Full text
Gray Matter Volume and Cognitive Performance During Normal Aging. A Voxel-Based Morphometry Study. / 2018 / PubMed / Full text
Oxidative Stress Function in Women over 40 Years of Age, Considering Their Lifestyle. / 2017 / PubMed / Full text
Age-related changes in retinoic, docosahexaenoic and arachidonic acid modulation in nuclear lipid metabolism. / 15.08.2016 / PubMed / Full text
Transcriptional and biochemical responses of monoacylglycerol acyltransferase-mediated oil synthesis and associated senescence-like responses in Nicotiana benthamiana. / 2014 / PubMed / Full text
Electromechanical delay of the knee extensor muscles: comparison among young, middle-age and older individuals. / 07.2015 / PubMed / Full text

MAP2

Protective effects of ischemic preconditioning against neuronal apoptosis and dendritic injury in the hippocampus are age-dependent. / 11.2020 / PubMed / Full text
SerThr-PhosphoProteome of Brain from Aged PINK1-KO A53T-SNCA Mice Reveals pT1928-MAP1B and pS3781-ANK2 Deficits, as Hub between Autophagy and Synapse Changes. / 04.07.2019 / PubMed / Full text
DNA methylation analysis on purified neurons and glia dissects age and Alzheimer's disease-specific changes in the human cortex. / 25.07.2018 / PubMed / Full text
Systemic overexpression of SQSTM1/p62 accelerates disease onset in a SOD1 -expressing ALS mouse model. / 29.05.2018 / PubMed / Full text
Long-term treadmill exercise improves memory impairment through restoration of decreased synaptic adhesion molecule 1/2/3 induced by transient cerebral ischemia in the aged gerbil hippocampus. / 03.2018 / PubMed / Full text
Synaptic Compensation as a Probable Cause of Prolonged Mild Cognitive Impairment in Alzheimer's Disease: Implications from a Transgenic Mouse Model of the Disease. / 2017 / PubMed / Full text
Loss of MAP function leads to hippocampal synapse loss and deficits in the Morris Water Maze with aging. / 21.05.2014 / PubMed / Full text
Removal of DELLA repression promotes leaf senescence in Arabidopsis. / 04.2014 / PubMed / Full text

MFI

The Influence of the Accelerated Aging Conditions on the Properties of Polyolefin Geogrids Used for Landfill Slope Reinforcement. / 20.08.2020 / PubMed / Full text
Changes in Physical Meat Traits, Protein Solubility, and the Microstructure of Different Beef Muscles during Post-Mortem Aging. / 19.06.2020 / PubMed / Full text
Effect of a low-voltage electrical stimulation on yak meat tenderness during postmortem aging. / 01-12.2020 / PubMed / Full text
Comparative effects of dry-aging and wet-aging on physicochemical properties and digestibility of Hanwoo beef. / 03.2020 / PubMed / Full text
Sexual dimorphism in rat thymic involution: a correlation with thymic oxidative status and inflammation. / 08.2019 / PubMed / Full text
Circulating soluble RAGE and cell surface RAGE on peripheral blood mononuclear cells in healthy children. / 27.06.2018 / PubMed / Full text
The frail fail: Increased mortality and post-operative complications in orthopaedic trauma patients. / 11.2017 / PubMed / Full text
Meat quality attributes of Agile Wallabies. / 11.2017 / PubMed / Full text

MIA

Age, cohort, and period effects on metamemory beliefs. / 12.2019 / PubMed / Full text
Memory Age-based Stereotype Threat: Role of Locus of Control and Anxiety. / 01-02.2020 / PubMed / Full text
Role of melanoma inhibitory activity in melanocyte senescence. / 11.2019 / PubMed / Full text
Refining the metamemory in adulthood questionnaire: a 20-item version of change and capacity designed for research and clinical settings. / 07.2020 / PubMed / Full text
Maternal Immune Activation Alters Adult Behavior, Gut Microbiome and Juvenile Brain Oscillations in Ferrets. / 09-10.2018 / PubMed / Full text
Differential proteomic and oxidative profiles unveil dysfunctional protein import to adipocyte mitochondria in obesity-associated aging and diabetes. / 04.2017 / PubMed / Full text
Development of monosodium acetate-induced osteoarthritis and inflammatory pain in ageing mice. / 06.2015 / PubMed / Full text
Factors associated with hypertension prevalence, awareness, treatment and control among participants in the International Mobility in Aging Study (IMIAS). / 02.2016 / PubMed / Full text

MITF

Thymocid , a Standardized Black Cumin ([i]Nigella sativa[/i]) Seed Extract, Modulates Collagen Cross-Linking, Collagenase and Elastase Activities, and Melanogenesis in Murine B16F10 Melanoma Cells. / 19.07.2020 / PubMed / Full text
HuRdling Senescence: HuR Breaks BRAF-Induced Senescence in Melanocytes and Supports Melanoma Growth. / 21.05.2020 / PubMed / Full text
Extracellular acidosis triggers a senescence-like phenotype in human melanoma cells. / 01.2020 / PubMed / Full text
H O promotes the aging process of melanogenesis through modulation of MITF and Nrf2. / 04.2019 / PubMed / Full text
Deregulated MITF sumoylation: A route to melanoma. / 2017 / PubMed / Full text
Phosphorylation of MITF by AKT affects its downstream targets and causes TP53-dependent cell senescence. / 11.2016 / PubMed / Full text
Parthenolide induces MITF-M downregulation and senescence in patient-derived MITF-M(high) melanoma cell populations. / 23.02.2016 / PubMed / Full text
Regulatory and functional connection of microphthalmia-associated transcription factor and anti-metastatic pigment epithelium derived factor in melanoma. / 06.2014 / PubMed / Full text

MMP3

Systemic analysis of gene expression profiles in porcine granulosa cells during aging. / 14.11.2017 / PubMed / Full text
Identification of a pyridine derivative inducing senescence in ovarian cancer cell lines via P21 activation. / 05.2018 / PubMed / Full text
Chronic Resveratrol Treatment Inhibits MRC5 Fibroblast SASP-Related Protumoral Effects on Melanoma Cells. / 01.09.2017 / PubMed / Full text
Sperm-associated antigen 9 (SPAG9) promotes the survival and tumor growth of triple-negative breast cancer cells. / 10.2016 / PubMed / Full text
Differential Matrix Metalloprotease (MMP) Expression Profiles Found in Aged Gingiva. / 2016 / PubMed / Full text
Role of SHOX2 in the development of intervertebral disc degeneration. / 05.2017 / PubMed / Full text
Biological Effects Induced by Specific Advanced Glycation End Products in the Reconstructed Skin Model of Aging. / 2015 / PubMed / Full text
Anti-photoaging potential of Botulinum Toxin Type A in UVB-induced premature senescence of human dermal fibroblasts in vitro through decreasing senescence-related proteins. / 05.04.2014 / PubMed / Full text

MOS

Effect of mannan oligosaccharides on the microbiota and productivity parameters of Litopenaeus vannamei shrimp under intensive cultivation in Ecuador. / 17.02.2020 / PubMed / Full text
Predictors of health-related quality of life among older adults living with HIV in Thailand: results from the baseline and follow-up surveys. / 23.12.2019 / PubMed / Full text
Comparison of health-related quality of life between the Han and Yi ethnicity elderly in the Yi autonomous areas of Yunnan Province. / 25.11.2019 / PubMed / Full text
Mannan oligosaccharide increases the growth performance, immunity and resistance capability against Vibro Parahemolyticus in juvenile abalone Haliotis discus hannai Ino. / 11.2019 / PubMed / Full text
A global human health risk assessment for octamethylcyclotetrasiloxane (D ). / 20.10.2017 / PubMed / Full text
Comprehensive Assessment of Compliance with Antimuscarinic Drug Treatment in the Case of Urge Urinary Incontinence of Older Patients. / 2017 / PubMed / Full text
Sleep Disordered Breathing and White Matter Hyperintensities in Community-Dwelling Elders. / 01.04.2016 / PubMed / Full text
Effects of narrow base gait on mediolateral balance control in young and older adults. / 03.05.2016 / PubMed / Full text

NNT

Yoga, Health-Related Quality of Life and Mental Well-Being: A Re-analysis of a Meta-analysis Using the Quality Effects Model. / 16.09.2020 / PubMed / Full text
Statins After Myocardial Infarction in the Oldest: A Cohort Study in the Clinical Practice Research Datalink Database. / 02.2020 / PubMed / Full text
Years of Life Lost for Older Patients After Colorectal Cancer Diagnosis. / 08.2019 / PubMed / Full text
Nicotinamide nucleotide transhydrogenase is required for brain mitochondrial redox balance under hampered energy substrate metabolism and high-fat diet. / 12.2018 / PubMed / Full text
Upregulation of mitochondrial NAD levels impairs the clonogenicity of SSEA1 glioblastoma tumor-initiating cells. / 09.06.2017 / PubMed / Full text
The Health Gain Obtainable from Pancreatic Resection for Adenocarcinoma in the Elderly. / 04.2017 / PubMed / Full text
Restoration of Mitochondrial NAD Levels Delays Stem Cell Senescence and Facilitates Reprogramming of Aged Somatic Cells. / 12.2016 / PubMed / Full text
Relative importance of redox buffers GSH and NAD(P)H in age-related neurodegeneration and Alzheimer disease-like mouse neurons. / 08.2014 / PubMed / Full text

NPS

Cortical β-amyloid burden, neuropsychiatric symptoms, and cognitive status: the Mayo Clinic Study of Aging. / 28.03.2019 / PubMed / Full text
Mild Behavioral Impairment as a Marker of Cognitive Decline in Cognitively Normal Older Adults. / 08.2019 / PubMed / Full text
The course of neuropsychiatric symptoms in patients with dementia in primary care. / 31.07.2019 / PubMed / Full text
Serum calcium levels and neuropsychological performance in depression and matched healthy controls: Reversal of correlation a marker of the aging cognitive clock? / 05.2018 / PubMed / Full text
Persistent use of psychotropic drugs in nursing home residents in Norway. / 13.02.2017 / PubMed / Full text
FDG-PET and Neuropsychiatric Symptoms among Cognitively Normal Elderly Persons: The Mayo Clinic Study of Aging. / 14.07.2016 / PubMed / Full text
Cardiorenal fibrosis and dysfunction in aging: Imbalance in mediators and regulators of collagen. / 02.2016 / PubMed / Full text
Personalized technology to support older adults with and without cognitive impairment living at home. / 02.2015 / PubMed / Full text

POLG

Maternal ageing impairs mitochondrial DNA kinetics during early embryogenesis in mice. / 08.07.2019 / PubMed / Full text
Parkin does not prevent accelerated cardiac aging in mitochondrial DNA mutator mice. / 16.04.2019 / PubMed / Full text
The effects of AICAR and rapamycin on mitochondrial function in immortalized mitochondrial DNA mutator murine embryonic fibroblasts. / 16.11.2018 / PubMed / Full text
Impact of exercise on oocyte quality in the POLG mitochondrial DNA mutator mouse. / 08.2018 / PubMed / Full text
The role of sodium hydrosulfide in attenuating the aging process via PI3K/AKT and CaMKKβ/AMPK pathways. / 08.2017 / PubMed / Full text
Metabolomic analysis of exercise effects in the POLG mitochondrial DNA mutator mouse brain. / 11.2015 / PubMed / Full text
Mitochondria DNA mutations cause sex-dependent development of hypertension and alterations in cardiovascular function. / 05.02.2015 / PubMed / Full text
Somatic mitochondrial DNA mutations do not increase neuronal vulnerability to MPTP in young POLG mutator mice. / 11-12.2014 / PubMed / Full text

RAD51

Loss of Slug Compromises DNA Damage Repair and Accelerates Stem Cell Aging in Mammary Epithelium. / 09.07.2019 / PubMed / Full text
Quantitative assessment of changes in cell growth, size and morphology during telomere-initiated cellular senescence in Saccharomyces cerevisiae. / 01.08.2019 / PubMed / Full text
Mechanistic link between DNA damage sensing, repairing and signaling factors and immune signaling. / 2019 / PubMed / Full text
The activated DNA double-strand break repair pathway in cumulus cells from aging patients may be used as a convincing predictor of poor outcomes after in vitro fertilization-embryo transfer treatment. / 2018 / PubMed / Full text
Artesunate enhances the therapeutic response of glioma cells to temozolomide by inhibition of homologous recombination and senescence. / 11.10.2016 / PubMed / Full text
BRCA-1 Gene Expression and Comparative Proteomic Profile of Primordial Follicles from Young and Adult Buffalo (Bubalus bubalis) Ovaries. / 03.04.2017 / PubMed / Full text
SQSTM1/p62 mediates crosstalk between autophagy and the UPS in DNA repair. / 02.10.2016 / PubMed / Full text
RECQL5 has unique strand annealing properties relative to the other human RecQ helicase proteins. / 01.2016 / PubMed / Full text

SQSTM1

The selective autophagy receptor SQSTM1/p62 improves lifespan and proteostasis in an evolutionarily conserved manner. / 04.2020 / PubMed / Full text
SIRT2 functions in aging, autophagy, and apoptosis in post-maturation bovine oocytes. / 01.09.2019 / PubMed / Full text
A pH probe inhibits senescence in mesenchymal stem cells. / 07.12.2018 / PubMed / Full text
The ATG5-binding and coiled coil domains of ATG16L1 maintain autophagy and tissue homeostasis in mice independently of the WD domain required for LC3-associated phagocytosis. / 04.2019 / PubMed / Full text
Systemic overexpression of SQSTM1/p62 accelerates disease onset in a SOD1 -expressing ALS mouse model. / 29.05.2018 / PubMed / Full text
SIRT6 histone deacetylase functions as a potential oncogene in human melanoma. / 09.2017 / PubMed / Full text
SQSTM1/p62 mediates crosstalk between autophagy and the UPS in DNA repair. / 02.10.2016 / PubMed / Full text
Defective autophagy in vascular smooth muscle cells accelerates senescence and promotes neointima formation and atherogenesis. / 02.11.2015 / PubMed / Full text

SUV39H1

Increase in hippocampal histone H3K9me3 is negatively correlated with memory in old male mice. / 04.2020 / PubMed / Full text
Triptolide Promotes Senescence of Prostate Cancer Cells Through Histone Methylation and Heterochromatin Formation / 27.09.2017 / PubMed / Full text
The Ubiquitin-like with PHD and Ring Finger Domains 1 (UHRF1)/DNA Methyltransferase 1 (DNMT1) Axis Is a Primary Regulator of Cell Senescence. / 03.03.2017 / PubMed / Full text
Age-Associated Decrease of the Histone Methyltransferase SUV39H1 in HSC Perturbs Heterochromatin and B Lymphoid Differentiation. / 14.06.2016 / PubMed / Full text
H3K9me3 Inhibition Improves Memory, Promotes Spine Formation, and Increases BDNF Levels in the Aged Hippocampus. / 23.03.2016 / PubMed / Full text
Stem Cell Depletion by Global Disorganization of the H3K9me3 Epigenetic Marker in Aging. / 08.2015 / PubMed / Full text
Aging stem cells. A Werner syndrome stem cell model unveils heterochromatin alterations as a driver of human aging. / 05.06.2015 / PubMed / Full text
SUV39H1 downregulation induces deheterochromatinization of satellite regions and senescence after exposure to ionizing radiation. / 2014 / PubMed / Full text

TRPM2

Paraquat as an Environmental Risk Factor in Parkinson's Disease Accelerates Age-Related Degeneration Via Rapid Influx of Extracellular Zn into Nigral Dopaminergic Neurons. / 11.2019 / PubMed / Full text
Pathophysiological Role of TRPM2 in Age-Related Cognitive Impairment in Mice. / 01.06.2019 / PubMed / Full text
The TRPM2 channel nexus from oxidative damage to Alzheimer's pathologies: An emerging novel intervention target for age-related dementia. / 11.2018 / PubMed / Full text
TRPM2 in the Brain: Role in Health and Disease. / 22.07.2018 / PubMed / Full text
mRNA expression of transient receptor potential melastatin (TRPM) channels 2 and 7 in perinatal brain development. / 10.2018 / PubMed / Full text
Prolactin protects retinal pigment epithelium by inhibiting sirtuin 2-dependent cell death. / 05.2016 / PubMed / Full text
Extended therapeutic window of a novel peptide inhibitor of TRPM2 channels following focal cerebral ischemia. / 09.2016 / PubMed / Full text
The Protective Role of Selenium on Scopolamine-Induced Memory Impairment, Oxidative Stress, and Apoptosis in Aged Rats: The Involvement of TRPM2 and TRPV1 Channels. / 05.2017 / PubMed / Full text

TRPV4

TRPV4 receptor as a functional sensory molecule in bladder urothelium: Stretch-independent, tissue-specific actions and pathological implications. / 01.2020 / PubMed / Full text
Exercise restores impaired endothelium-derived hyperpolarizing factor-mediated vasodilation in aged rat aortic arteries via the TRPV4-K 2.3 signaling complex. / 2019 / PubMed / Full text
Autonomic dysregulation at multiple sites is implicated in age-associated underactive bladder in female mice. / 06.2019 / PubMed / Full text
Reduced bladder responses to capsaicin and GSK-1016790A in retired-breeder female rats with diminished volume sensitivity. / 01.11.2018 / PubMed / Full text
Cartilage-Specific Knockout of the Mechanosensory Ion Channel TRPV4 Decreases Age-Related Osteoarthritis. / 08.07.2016 / PubMed / Full text
Increasing TRPV4 expression restores flow-induced dilation impaired in mesenteric arteries with aging. / 07.03.2016 / PubMed / Full text
Berberine via suppression of transient receptor potential vanilloid 4 channel improves vascular stiffness in mice. / 11.2015 / PubMed / Full text
Age-related changes in the distribution of transient receptor potential vanilloid 4 channel (TRPV4) in the central nervous system of rats. / 10.2014 / PubMed / Full text

VWF

Von Willebrand disease in the elderly: clinical perspectives. / 2018 / PubMed / Full text
Comorbidities associated with higher von Willebrand factor (VWF) levels may explain the age-related increase of VWF in von Willebrand disease. / 07.2018 / PubMed / Full text
The Association of Aging With Von Willebrand Factor Levels and Bleeding Risk in Type 1 Von Willebrand Disease. / 04.2018 / PubMed / Full text
Aging and ABO blood type influence von Willebrand factor and factor VIII levels through interrelated mechanisms. / 05.2016 / PubMed / Full text
Age-related changes in platelet function are more profound in women than in men. / 16.07.2015 / PubMed / Full text
Von Willebrand factor and aging. / 09.2014 / PubMed / Full text
Aging hemostasis: changes to laboratory markers of hemostasis as we age - a narrative review. / 09.2014 / PubMed / Full text
von Willebrand disease and aging: an evolving phenotype. / 07.2014 / PubMed / Full text

ACTN3

The Role of Genetic Profile in Functional Performance Adaptations to Exercise Training or Physical Activity: A Systematic Review of the Literature. / 01.08.2019 / PubMed / Full text
Is evolutionary loss our gain? The role of ACTN3 p.Arg577Ter (R577X) genotype in athletic performance, ageing, and disease. / 12.2018 / PubMed / Full text
ACTN3 genotype and physical function and frailty in an elderly Chinese population: the Rugao Longevity and Ageing Study. / 01.05.2018 / PubMed / Full text
Muscle-Related Polymorphisms (MSTN rs1805086 and ACTN3 rs1815739) Are Not Associated with Exceptional Longevity in Japanese Centenarians. / 2016 / PubMed / Full text
Genetic variation and exercise-induced muscle damage: implications for athletic performance, injury and ageing. / 09.2016 / PubMed / Full text
The ACTN3 R577X genotype is associated with muscle function in a Japanese population. / 04.2015 / PubMed / Full text
1000 Norms Project: protocol of a cross-sectional study cataloging human variation. / 03.2016 / PubMed / Full text

AMT

A multi-method comparison of autobiographical memory impairments amongst younger and older adults. / 12.03.2020 / PubMed / Full text
Autobiographical Memory From Different Life Stages in Individuals With Obstructive Sleep Apnea. / 03.2019 / PubMed / Full text
Fatigue in Younger and Older Drivers: Effectiveness of an Alertness-Maintaining Task. / 09.2017 / PubMed / Full text
Reduced specificity and enhanced subjective experience of future thinking in ageing: the influence of avoidance and emotion-regulation strategies. / 01.2018 / PubMed / Full text
Evaluation of delirium screening tools in geriatric medical inpatients: a diagnostic test accuracy study. / 11.2016 / PubMed / Full text
Falls and other geriatric syndromes in Blantyre, Malawi: a community survey of older adults. / 12.2014 / PubMed / Full text
Cognitive assessment of elderly inpatients: a clinical audit. / 01-04.2015 / PubMed / Full text

ATF3

ATF3 represses PINK1 gene transcription in lung epithelial cells to control mitochondrial homeostasis. / 04.2018 / PubMed / Full text
p38 MAPK inhibits nonsense-mediated RNA decay in response to persistent DNA damage in noncycling cells. / 15.09.2017 / PubMed / Full text
Aging Triggers Cytoplasmic Depletion and Nuclear Translocation of the E3 Ligase Mahogunin: A Function for Ubiquitin in Neuronal Survival. / 04.05.2017 / PubMed / Full text
Rutin protects against aging-related metabolic dysfunction. / 02.2016 / PubMed / Full text
Neuroimmune and Neuropathic Responses of Spinal Cord and Dorsal Root Ganglia in Middle Age. / 2015 / PubMed / Full text
Activation of autophagic pathways is related to growth inhibition and senescence in cutaneous squamous cell carcinoma. / 10.2014 / PubMed / Full text
Age-related brain expression and regulation of the chemokine CCL4/MIP-1β in APP/PS1 double-transgenic mice. / 04.2014 / PubMed / Full text

ATG12

Lifelong Football Training: Effects on Autophagy and Healthy Longevity Promotion. / 2019 / PubMed / Full text
SIRT6 histone deacetylase functions as a potential oncogene in human melanoma. / 09.2017 / PubMed / Full text
Epigallocatechin-3-gallate increases autophagy signaling in resting and unloaded plantaris muscles but selectively suppresses autophagy protein abundance in reloaded muscles of aged rats. / 06.2017 / PubMed / Full text
Changes in macroautophagy, chaperone-mediated autophagy, and mitochondrial metabolism in murine skeletal and cardiac muscle during aging. / 26.02.2017 / PubMed / Full text
Autophagic homeostasis is required for the pluripotency of cancer stem cells. / 02.2017 / PubMed / Full text
Macroautophagy is impaired in old murine brain tissue as well as in senescent human fibroblasts. / 12.2016 / PubMed / Full text
Follicle-stimulating hormone promotes age-related endometrial atrophy through cross-talk with transforming growth factor beta signal transduction pathway. / 04.2015 / PubMed / Full text

B2M

The relationships between markers of tubular injury and intrarenal haemodynamic function in adults with and without type 1 diabetes: Results from the Canadian Study of Longevity in Type 1 Diabetes. / 03.2019 / PubMed / Full text
Association between serum β2-microglobulin levels and frailty in an elderly Chinese population: results from RuLAS. / 2017 / PubMed / Full text
Non-GFR Determinants of Low-Molecular-Weight Serum Protein Filtration Markers in the Elderly: AGES-Kidney and MESA-Kidney. / 09.2017 / PubMed / Full text
Association Between Serum β -Microglobulin Levels and Prevalent and Incident Physical Frailty in Community-Dwelling Older Women. / 04.2017 / PubMed / Full text
A single heterochronic blood exchange reveals rapid inhibition of multiple tissues by old blood. / 22.11.2016 / PubMed / Full text
β2-microglobulin is a systemic pro-aging factor that impairs cognitive function and neurogenesis. / 08.2015 / PubMed / Full text
Systemic attenuation of the TGF-β pathway by a single drug simultaneously rejuvenates hippocampal neurogenesis and myogenesis in the same old mammal. / 20.05.2015 / PubMed / Full text

BIN1

Amphiphysin 2 modulation rescues myotubular myopathy and prevents focal adhesion defects in mice. / 20.03.2019 / PubMed / Full text
Recent studies on cellular and molecular mechanisms in Alzheimer's disease: focus on epigenetic factors and histone deacetylase. / 28.03.2018 / PubMed / Full text
Association and interaction effects of Alzheimer's disease-associated genes and lifestyle on cognitive aging in older adults in a Taiwanese population. / 11.04.2017 / PubMed / Full text
Dopamine Receptor Genes Modulate Associative Memory in Old Age. / 02.2017 / PubMed / Full text
Gene-based aggregate SNP associations between candidate AD genes and cognitive decline. / 04.2016 / PubMed / Full text
Association of Alzheimer's disease GWAS loci with MRI markers of brain aging. / 04.2015 / PubMed / Full text
The benefits of staying active in old age: physical activity counteracts the negative influence of PICALM, BIN1, and CLU risk alleles on episodic memory functioning. / 06.2014 / PubMed / Full text

C9

C9orf72 in myeloid cells suppresses STING-induced inflammation. / 09.2020 / PubMed / Full text
Glycine-alanine dipeptide repeats spread rapidly in a repeat length- and age-dependent manner in the fly brain. / 16.12.2019 / PubMed / Full text
Human iPSC-derived astrocytes from ALS patients with mutated C9ORF72 show increased oxidative stress and neurotoxicity. / 12.2019 / PubMed / Full text
Age and Sex-Associated Changes of Complement Activity and Complement Levels in a Healthy Caucasian Population. / 2018 / PubMed / Full text
TMT-Based Quantitative Proteomic Analysis Reveals Proteomic Changes Involved in Longevity. / 07.2019 / PubMed / Full text
C9orf72 Dipeptide Repeats Cause Selective Neurodegeneration and Cell-Autonomous Excitotoxicity in [i]Drosophila[/i] Glutamatergic Neurons. / 29.08.2018 / PubMed / Full text
Extended Multiplexing of Tandem Mass Tags (TMT) Labeling Reveals Age and High Fat Diet Specific Proteome Changes in Mouse Epididymal Adipose Tissue. / 05.2017 / PubMed / Full text

C9orf72

Carriership of two copies of C9orf72 hexanucleotide repeat intermediate-length alleles is a risk factor for ALS in the Finnish population. / 09.11.2020 / PubMed / Full text
C9orf72 Dipeptide Repeats Cause Selective Neurodegeneration and Cell-Autonomous Excitotoxicity in [i]Drosophila[/i] Glutamatergic Neurons. / 29.08.2018 / PubMed / Full text
Age-related penetrance of the C9orf72 repeat expansion. / 18.05.2017 / PubMed / Full text
DNA methylation age-acceleration is associated with disease duration and age at onset in C9orf72 patients. / 08.2017 / PubMed / Full text
C9orf72 is required for proper macrophage and microglial function in mice. / 18.03.2016 / PubMed / Full text
Effects of Cellular Pathway Disturbances on Misfolded Superoxide Dismutase-1 in Fibroblasts Derived from ALS Patients. / 2016 / PubMed / Full text
Frontotemporal dementia: insights into the biological underpinnings of disease through gene co-expression network analysis. / 24.02.2016 / PubMed / Full text

CD9

Exosomal Notch3 from high glucose-stimulated endothelial cells regulates vascular smooth muscle cells calcification/aging. / 01.09.2019 / PubMed / Full text
Effects of RSC96 Schwann Cell-Derived Exosomes on Proliferation, Senescence, and Apoptosis of Dorsal Root Ganglion Cells In Vitro. / 02.11.2018 / PubMed / Full text
Identification of functionally distinct fibro-inflammatory and adipogenic stromal subpopulations in visceral adipose tissue of adult mice. / 28.09.2018 / PubMed / Full text
MicroRNA-183-5p Increases with Age in Bone-Derived Extracellular Vesicles, Suppresses Bone Marrow Stromal (Stem) Cell Proliferation, and Induces Stem Cell Senescence. / 11.2017 / PubMed / Full text
Mitochondria defects are involved in lead-acetate-induced adult hematopoietic stem cell decline. / 19.05.2015 / PubMed / Full text
Therapeutic efficacy of bone marrow-derived mononuclear cells in diabetic polyneuropathy is impaired with aging or diabetes. / 03.2015 / PubMed / Full text
Age-related changes in tissue macrophages precede cardiac functional impairment. / 05.2014 / PubMed / Full text

CDK5

Age-related hyperinsulinemia leads to insulin resistance in neurons and cell-cycle-induced senescence. / 11.2019 / PubMed / Full text
CK2 inhibition protects white matter from ischemic injury. / 20.11.2018 / PubMed / Full text
CK2 inhibition confers functional protection to young and aging axons against ischemia by differentially regulating the CDK5 and AKT signaling pathways. / 06.2019 / PubMed / Full text
The pathological roles of NDRG2 in Alzheimer's disease, a study using animal models and APPwt-overexpressed cells. / 08.2017 / PubMed / Full text
APOE4 Induces Site-Specific Tau Phosphorylation Through Calpain-CDK5 Signaling Pathway in EFAD-Tg Mice. / 2016 / PubMed / Full text
GENETICS OF HUMAN AGE RELATED DISORDERS. / 2015 / PubMed
Surgical stress induces brain-derived neurotrophic factor reduction and postoperative cognitive dysfunction via glucocorticoid receptor phosphorylation in aged mice. / 05.2015 / PubMed / Full text

COMP

Effect of circadian rhythm, age, training and acute lameness on serum concentrations of cartilage oligomeric matrix protein (COMP) neo-epitope in horses. / 09.2019 / PubMed / Full text
Genetic overexpression of COMP-Ang1 impairs BM microenvironment and induces senescence of BM HSCs. / 15.05.2018 / PubMed / Full text
Longitudinal Twin Study of Subjective Health: Differences in Genetic and Environmental Components of Variance Across Age and Sex. / 01.01.2020 / PubMed / Full text
Cartilage biomarkers in the osteoarthropathy of alkaptonuria reveal low turnover and accelerated ageing. / 01.2017 / PubMed / Full text
Scleraxis Is Essential for Tendon Differentiation by Equine Embryonic Stem Cells and in Equine Fetal Tenocytes. / 15.03.2017 / PubMed / Full text
Cartilage oligomeric matrix protein prevents vascular aging and vascular smooth muscle cells senescence. / 16.09.2016 / PubMed / Full text
Fibrotic-like changes in degenerate human intervertebral discs revealed by quantitative proteomic analysis. / 03.2016 / PubMed / Full text

CTSB

Myocardial cathepsin D is downregulated in sudden cardiac death. / 2020 / PubMed / Full text
A Free Radical-Generating System Regulates Amyloid Oligomers: Involvement of Cathepsin B. / 2018 / PubMed / Full text
SIRT6 histone deacetylase functions as a potential oncogene in human melanoma. / 09.2017 / PubMed / Full text
Involvement of lysosomal dysfunction in autophagosome accumulation and early pathologies in adipose tissue of obese mice. / 03.04.2017 / PubMed / Full text
Running-Induced Systemic Cathepsin B Secretion Is Associated with Memory Function. / 09.08.2016 / PubMed / Full text
The association of serum cathepsin B concentration with age-related cardiovascular-renal subclinical state in a healthy Chinese population. / 07-08.2016 / PubMed / Full text
Decreased serum level of HMGB1 and MyD88 during human aging progress in healthy individuals. / 04.2016 / PubMed / Full text

CX3CL1

Two forms of CX3CL1 display differential activity and rescue cognitive deficits in CX3CL1 knockout mice. / 14.05.2020 / PubMed / Full text
Expression of pro- and anti-inflammatory cytokines and chemokines during the ovulatory cycle and effects of aging on their expression in the uterine mucosa of laying hens. / 11.2018 / PubMed / Full text
Towards frailty biomarkers: Candidates from genes and pathways regulated in aging and age-related diseases. / 11.2018 / PubMed / Full text
Surgical Trauma Exacerbates Cognitive Deficits and Neuroinflammation in Aged Rats: The Role of CX3CL1-CX3CR1 Signaling. / 01.08.2018 / PubMed / Full text
Repopulating retinal microglia restore endogenous organization and function under CX3CL1-CX3CR1 regulation. / 03.2018 / PubMed / Full text
Microglia and Aging: The Role of the TREM2-DAP12 and CX3CL1-CX3CR1 Axes. / 22.01.2018 / PubMed / Full text
Nilotinib and bosutinib modulate pre-plaque alterations of blood immune markers and neuro-inflammation in Alzheimer's disease models. / 24.09.2015 / PubMed / Full text

CXCL2

Inflammatory and Senescent Phenotype of Pancreatic Stellate Cells Induced by Sqstm1 Downregulation Facilitates Pancreatic Cancer Progression. / 2019 / PubMed / Full text
Long-term every-other-day administration of DMAMCL has little effect on aging and age-associated physiological decline in mice. / 02.05.2019 / PubMed / Full text
A Neutrophil Timer Coordinates Immune Defense and Vascular Protection. / 19.02.2019 / PubMed / Full text
Excessive neutrophil levels in the lung underlie the age-associated increase in influenza mortality. / 03.2019 / PubMed / Full text
Time-Dependent Changes in Local and Serum Levels of Inflammatory Cytokines as Markers for Incised Wound Aging of Skeletal Muscles. / 05.2018 / PubMed / Full text
Tumor microenvironment in functional adrenocortical adenomas: immune cell infiltration in cortisol-producing adrenocortical adenoma. / 07.2018 / PubMed / Full text
Palmitate promotes inflammatory responses and cellular senescence in cardiac fibroblasts. / 02.2017 / PubMed / Full text

CXCR3

Senescent hepatocytes enhance natural killer cell activity via the CXCL-10/CXCR3 axis. / 11.2019 / PubMed / Full text
Age-associated antigen-presenting cell alterations promote dry-eye inducing Th1 cells. / 07.2019 / PubMed / Full text
CXCR3 CD8 T cells with naïve phenotype and high capacity for IFN-γ production are generated during homeostatic T-cell proliferation. / 10.2018 / PubMed / Full text
The parasite-derived rOv-ASP-1 is an effective antigen-sparing CD4 T cell-dependent adjuvant for the trivalent inactivated influenza vaccine, and functions in the absence of MyD88 pathway. / 14.06.2018 / PubMed / Full text
Calorie Restriction Attenuates Terminal Differentiation of Immune Cells. / 2016 / PubMed / Full text
Circulating T helper and T regulatory subsets in untreated early rheumatoid arthritis and healthy control subjects. / 10.2016 / PubMed / Full text
Trafficking phenotype and production of granzyme B by double negative B cells (IgG( )IgD(-)CD27(-)) in the elderly. / 06.2014 / PubMed / Full text

DCN

Decorin inhibits the insulin-like growth factor I signaling in bone marrow mesenchymal stem cells of aged humans. / 26.11.2020 / PubMed / Full text
The beneficial effects of 15 units of high-intensity circuit training in women is modified by age, baseline insulin resistance and physical capacity. / 06.2019 / PubMed / Full text
MicroRNA-143-5p targeting eEF2 gene mediates intervertebral disc degeneration through the AMPK signaling pathway. / 15.04.2019 / PubMed / Full text
Does Age Interfere With Gadolinium Toxicity and Presence in Brain and Bone Tissues?: A Comparative Gadoterate Versus Gadodiamide Study in Juvenile and Adult Rats. / 02.2019 / PubMed / Full text
Extracellular proteoglycan decorin maintains human hair follicle stem cells. / 12.2018 / PubMed / Full text
Synaptic Specializations Support Frequency-Independent Purkinje Cell Output from the Cerebellar Cortex. / 20.12.2016 / PubMed / Full text
The aging human cochlear nucleus: Changes in the glial fibrillary acidic protein, intracellular calcium regulatory proteins, GABA neurotransmitter and cholinergic receptor. / 03.2014 / PubMed / Full text

DNMT3B

Alcohol Extracts From [i]Ganoderma lucidum[/i] Delay the Progress of Alzheimer's Disease by Regulating DNA Methylation in Rodents. / 2019 / PubMed / Full text
Human iPSC-derived MSCs (iMSCs) from aged individuals acquire a rejuvenation signature. / 18.03.2019 / PubMed / Full text
Effects of Parental Aging During Embryo Development and Adult Life: The Case of Nothobranchius furzeri. / 04.2018 / PubMed / Full text
Induced Pluripotent Stem Cell-Derived Dopaminergic Neurons from Adult Common Marmoset Fibroblasts. / 01.09.2017 / PubMed / Full text
Forkhead box A2 regulates biliary heterogeneity and senescence during cholestatic liver injury in mice‡. / 02.2017 / PubMed / Full text
Age-dependent expression of DNMT1 and DNMT3B in PBMCs from a large European population enrolled in the MARK-AGE study. / 08.2016 / PubMed / Full text
Insight into the molecular pathophysiology of myelodysplastic syndromes: targets for novel therapy. / 10.2016 / PubMed / Full text

FAAH

Endocannabinoid genetic variation enhances vulnerability to THC reward in adolescent female mice. / 02.2020 / PubMed / Full text
Pharmacological convergence reveals a lipid pathway that regulates C. elegans lifespan. / 05.2019 / PubMed / Full text
Stimulation of brain glucose uptake by cannabinoid CB2 receptors and its therapeutic potential in Alzheimer's disease. / 11.2016 / PubMed / Full text
Sustained Endocannabinoid Signaling Compromises Decidual Function and Promotes Inflammation-induced Preterm Birth. / 08.04.2016 / PubMed / Full text
Decreased anxiety in juvenile rats following exposure to low levels of chlorpyrifos during development. / 03.2017 / PubMed / Full text
Enhanced microglial activity in FAAH(-/-) animals. / 01.10.2015 / PubMed / Full text
Normal aging in rats and pathological aging in human Alzheimer's disease decrease FAAH activity: modulation by cannabinoid agonists. / 12.2014 / PubMed / Full text

GBA

Reduced sphingolipid hydrolase activities, substrate accumulation and ganglioside decline in Parkinson's disease. / 08.11.2019 / PubMed / Full text
Glycosphingolipid levels and glucocerebrosidase activity are altered in normal aging of the mouse brain. / 07.2018 / PubMed / Full text
GBA mutations in Parkinson disease: earlier death but similar neuropathological features. / 11.2017 / PubMed / Full text
Cognitive and motor functioning in elderly glucocerebrosidase mutation carriers. / 10.2017 / PubMed / Full text
Age and gender-specific reference intervals for lysosomal enzymes in dried blood spot samples: A study in Indian population. / 10.2017 / PubMed / Full text
Minos-insertion mutant of the Drosophila GBA gene homologue showed abnormal phenotypes of climbing ability, sleep and life span with accumulation of hydroxy-glucocerebroside. / 30.05.2017 / PubMed / Full text
Impact of lysosomal storage disorders on biology of mesenchymal stem cells: Evidences from in vitro silencing of glucocerebrosidase (GBA) and alpha-galactosidase A (GLA) enzymes. / 12.2017 / PubMed / Full text

GHRH

Physiological and metabolic features of mice with CRISPR/Cas9-mediated loss-of-function in growth hormone-releasing hormone. / 18.05.2020 / PubMed / Full text
Transcriptomic and metabolomic profiling of long-lived growth hormone releasing hormone knock-out mice: evidence for altered mitochondrial function and amino acid metabolism. / 23.02.2020 / PubMed / Full text
Roles of peptides and steroids in sleep disorders. / 09.2006 / PubMed / Full text
Growth Hormone Deficiency: Health and Longevity. / 01.04.2019 / PubMed / Full text
Aromatized Estrogens Amplify Nocturnal Growth Hormone Secretion in Testosterone-Replaced Older Hypogonadal Men. / 01.12.2018 / PubMed / Full text
Bioactive growth hormone in older men and women: It's relationship to immune markers and healthspan. / 06.2017 / PubMed / Full text
The Somatotrope Growth Hormone-Releasing Hormone/Growth Hormone/Insulin-Like Growth Factor-1 Axis in Immunoregulation and Immunosenescence. / 2017 / PubMed / Full text

GK

Progression of diabetic kidney disease in T2DN rats. / 01.12.2019 / PubMed / Full text
Reactive oxygen species-induced changes in glucose and lipid metabolism contribute to the accumulation of cholesterol in the liver during aging. / 04.2019 / PubMed / Full text
Age-Related Reduction of Contractile Responses to Urotensin II Is Seen in Aortas from Wistar Rats but Not from Type 2 Diabetic Goto-Kakizaki Rats. / 04.2017 / PubMed / Full text
[STUDY RELATIVE EXPRESSION OF GENES THAT CONTROL GLUCOSE METABOLISM IN THE LIVER IN MICE WITH DEVELOPMENT OF MELANOCORTIN OBESITY]. / 06.2015 / PubMed
Delta Cell Hyperplasia in Adult Goto-Kakizaki (GK/MolTac) Diabetic Rats. / 2015 / PubMed / Full text
Vascular, oxidative, and synaptosomal abnormalities during aging and the progression of type 2 diabetes. / 2014 / PubMed / Full text
Evidence for cortical neuronal loss in male type 2 diabetic Goto-Kakizaki rats. / 2014 / PubMed / Full text

GLA

TLR-adjuvanted nanoparticle vaccines differentially influence the quality and longevity of responses to malaria antigen Pfs25. / 17.05.2018 / PubMed / Full text
Gamma-linolenic acid ameliorated glycation-induced memory impairment in rats. / 12.2017 / PubMed / Full text
Age and gender-specific reference intervals for lysosomal enzymes in dried blood spot samples: A study in Indian population. / 10.2017 / PubMed / Full text
Impact of lysosomal storage disorders on biology of mesenchymal stem cells: Evidences from in vitro silencing of glucocerebrosidase (GBA) and alpha-galactosidase A (GLA) enzymes. / 12.2017 / PubMed / Full text
In vitro cytokine induction by TLR-activating vaccine adjuvants in human blood varies by age and adjuvant. / 07.2016 / PubMed / Full text
The stimulatory effect of the TLR4-mediated adjuvant glucopyranosyl lipid A is well preserved in old age. / 02.2016 / PubMed / Full text
Genome-wide association study of plasma N6 polyunsaturated fatty acids within the cohorts for heart and aging research in genomic epidemiology consortium. / 06.2014 / PubMed / Full text

HCN4

Structural and functional remodeling of the atrioventricular node with aging in rats: The role of hyperpolarization-activated cyclic nucleotide-gated and ryanodine 2 channels. / 05.2018 / PubMed / Full text
Age-dependent down-regulation of hyperpolarization-activated cyclic nucleotide-gated channel 4 causes deterioration of canine sinoatrial node function. / 01.05.2017 / PubMed / Full text
Characteristics of hyperpolarization-activated cyclic nucleotide-gated channels in dorsal root ganglion neurons at different ages and sizes. / 11.11.2015 / PubMed / Full text
Age-associated expression of HCN channel isoforms in rat sinoatrial node. / 02.2016 / PubMed / Full text
Altered expression of hyperpolarization-activated cyclic nucleotide-gated channels and microRNA-1 and -133 in patients with age-associated atrial fibrillation. / 09.2015 / PubMed / Full text
Differential expression of hyperpolarization-activated cyclic nucleotide-gated channel subunits during hippocampal development in the mouse. / 27.02.2015 / PubMed / Full text
Association between reversal in the expression of hyperpolarization-activated cyclic nucleotide-gated (HCN) channel and age-related atrial fibrillation. / 14.11.2014 / PubMed / Full text

HDAC6

Inhibition of HDAC6 Attenuates Diabetes-Induced Retinal Redox Imbalance and Microangiopathy. / 09.07.2020 / PubMed / Full text
Cellular senescence is associated with reorganization of the microtubule cytoskeleton. / 03.2019 / PubMed / Full text
2,4‑Di‑tert‑butylphenol, a potential HDAC6 inhibitor, induces senescence and mitotic catastrophe in human gastric adenocarcinoma AGS cells. / 05.2018 / PubMed / Full text
HDAC6 Suppresses Age-Dependent Ectopic Fat Accumulation by Maintaining the Proteostasis of PLIN2 in Drosophila. / 09.10.2017 / PubMed / Full text
The Deacetylase HDAC6 Mediates Endogenous Neuritic Tau Pathology. / 29.08.2017 / PubMed / Full text
Declined Expression of Histone Deacetylase 6 Contributes to Periodontal Ligament Stem Cell Aging. / 01.2017 / PubMed / Full text
Non-sirtuin histone deacetylases in the control of cardiac aging. / 06.2015 / PubMed / Full text

HFE

Polyphenol Characterization and Skin-Preserving Properties of Hydroalcoholic Flower Extract from [i]Himantoglossum robertianum[/i] (Orchidaceae). / 14.11.2019 / PubMed / Full text
Hydroalcoholic extract of Spartium junceum L. flowers inhibits growth and melanogenesis in B16-F10 cells by inducing senescence. / 15.07.2018 / PubMed / Full text
Iron-processing genotypes, nutrient intakes, and cadmium levels in the Normative Aging Study: Evidence of sensitive subpopulations in cadmium risk assessment. / 10.2018 / PubMed / Full text
Lead-Related Genetic Loci, Cumulative Lead Exposure and Incident Coronary Heart Disease: The Normative Aging Study. / 2016 / PubMed / Full text
Haplotype analysis of the HFE gene among populations of Northern Eurasia, in patients with metabolic disorders or stomach cancer, and in long-lived people. / 17.06.2016 / PubMed / Full text
No Association between Variation in Longevity Candidate Genes and Aging-related Phenotypes in Oldest-old Danes. / 06.2016 / PubMed / Full text
Cumulative lead exposure is associated with reduced olfactory recognition performance in elderly men: The Normative Aging Study. / 07.2015 / PubMed / Full text

HMOX1

Well-aging: A new strategy for skin homeostasis under multi-stressed conditions. / 02.2020 / PubMed / Full text
Age-related distribution and potential role of SNCB in topographically different retinal areas of the common marmoset Callithrix jacchus, including the macula. / 08.2019 / PubMed / Full text
Lead-Related Genetic Loci, Cumulative Lead Exposure and Incident Coronary Heart Disease: The Normative Aging Study. / 2016 / PubMed / Full text
Exercise-induced Nrf2-signaling is impaired in aging. / 07.2016 / PubMed / Full text
Behaviour and cognitive changes correlated with hippocampal neuroinflammaging and neuronal markers in female SAMP8, a model of accelerated senescence. / 07.2016 / PubMed / Full text
Neurotherapeutic effects of novel HO-1 inhibitors in vitro and in a transgenic mouse model of Alzheimer's disease. / 12.2014 / PubMed / Full text
Astroglial heme oxygenase-1 and the origin of corpora amylacea in aging and degenerating neural tissues. / 04.2014 / PubMed / Full text

IDE

Dendrobium nobile Lindl. Alkaloids Ameliorate Cognitive Dysfunction in Senescence Accelerated SAMP8 Mice by Decreasing Amyloid-β Aggregation and Enhancing Autophagy Activity. / 2020 / PubMed / Full text
Hyperinsulinemia is associated with increasing insulin secretion but not with decreasing insulin clearance in an age-related metabolic dysfunction mice model. / 06.2019 / PubMed / Full text
Effect of the Interplay Between Genetic and Behavioral Risks on Survival After Age 75. / 12.2016 / PubMed / Full text
Genetic factors moderate everyday physical activity effects on executive functions in aging: Evidence from the Victoria Longitudinal Study. / 01.2016 / PubMed / Full text
Enhanced Phospholipase A2 Group 3 Expression by Oxidative Stress Decreases the Insulin-Degrading Enzyme. / 2015 / PubMed / Full text
Effects of ageing and experimental diabetes on insulin-degrading enzyme expression in male rat tissues. / 08.2015 / PubMed / Full text
IDE (rs6583817) polymorphism and pulse pressure are independently and interactively associated with level and change in executive function in older adults. / 06.2014 / PubMed / Full text

LBR

Lamin B receptor: role on chromatin structure, cellular senescence and possibly aging. / 31.07.2020 / PubMed / Full text
The impact of age beyond ploidy: outcome data from 8175 euploid single embryo transfers. / 03.2020 / PubMed / Full text
The role of lamin B receptor in the regulation of senescence-associated secretory phenotype (SASP). / 01.05.2020 / PubMed / Full text
Lamin B receptor plays a key role in cellular senescence induced by inhibition of the proteasome. / 11.12.2019 / PubMed / Full text
Lamin B receptor (LBR) is involved in the induction of cellular senescence in human cells. / 03.2019 / PubMed / Full text
Consequences of Lamin B1 and Lamin B Receptor Downregulation in Senescence. / 06.02.2018 / PubMed / Full text
Overexpression of Lamin B Receptor Results in Impaired Skin Differentiation. / 2015 / PubMed / Full text

MMD

Association between a Deficit Accumulation Frailty Index and Mobility Outcomes in Older Adults: Secondary Analysis of the Lifestyle Interventions and Independence for Elders (LIFE) Study. / 22.11.2020 / PubMed / Full text
Impact of Anticholinergic Medication Burden on Mobility and Falls in the Lifestyle Interventions for Elders (LIFE) Study. / 16.09.2020 / PubMed / Full text
Impact and Lessons From the Lifestyle Interventions and Independence for Elders (LIFE) Clinical Trials of Physical Activity to Prevent Mobility Disability. / 04.2020 / PubMed / Full text
Lactobacillus rescues postnatal neurobehavioral and microglial dysfunction in a model of maternal microbiome dysbiosis. / 10.2019 / PubMed / Full text
A Case for Promoting Movement Medicine: Preventing Disability in the LIFE Randomized Controlled Trial. / 04.10.2019 / PubMed / Full text
Determinants of Basal Collaterals in Moyamoya Disease: Clinical and Genetic Factors. / 2016 / PubMed / Full text
Antihypertensive Use and the Effect of a Physical Activity Intervention in the Prevention of Major Mobility Disability Among Older Adults: The LIFE Study. / 07.2016 / PubMed / Full text

NRAS

Senescent cholangiocytes release extracellular vesicles that alter target cell phenotype via the epidermal growth factor receptor. / 10.2020 / PubMed / Full text
STAT3 Relays a Differential Response to Melanoma-Associated [i]NRAS[/i] Mutations. / 02.01.2020 / PubMed / Full text
Cooperation of Dnmt3a R878H with Nras G12D promotes leukemogenesis in knock-in mice: a pilot study. / 08.11.2019 / PubMed / Full text
Sequential acquisition of mutations in myelodysplastic syndromes. / 2017 / PubMed / Full text
ETS Proto-oncogene 1 Transcriptionally Up-regulates the Cholangiocyte Senescence-associated Protein Cyclin-dependent Kinase Inhibitor 2A. / 24.03.2017 / PubMed / Full text
Trametinib radiosensitises RAS- and BRAF-mutated melanoma by perturbing cell cycle and inducing senescence. / 11.2015 / PubMed / Full text
Registered report: senescence surveillance of pre-malignant hepatocytes limits liver cancer development. / 26.01.2015 / PubMed / Full text

NRF1

Maternal ageing impairs mitochondrial DNA kinetics during early embryogenesis in mice. / 08.07.2019 / PubMed / Full text
Photobiomodulation and Coenzyme Q Treatments Attenuate Cognitive Impairment Associated With Model of Transient Global Brain Ischemia in Artificially Aged Mice. / 2019 / PubMed / Full text
Androgen receptor polyglutamine expansion drives age-dependent quality control defects and muscle dysfunction. / 01.08.2018 / PubMed / Full text
Response of BAX, Bcl-2 Proteins, and SIRT1/PGC-1α mRNA Expression to 8-Week Treadmill Running in the Aging Rat Skeletal Muscle. / 2016 / PubMed / Full text
mTORC1 signaling activates NRF1 to increase cellular proteasome levels. / 2015 / PubMed / Full text
Stressed SIRT7: facing a crossroad of senescence and immortality. / 06.2015 / PubMed / Full text
The thyroid hormone receptor β induces DNA damage and premature senescence. / 06.01.2014 / PubMed / Full text

NTS

Neuropeptide changes in the suprachiasmatic nucleus are associated with the development of hypertension. / 08.2019 / PubMed / Full text
Aging affects isoproterenol-induced water drinking, astrocyte density, and central neuronal activation in female Brown Norway rats. / 01.08.2018 / PubMed / Full text
Neural processing of basic tastes in healthy young and older adults - an fMRI study. / 01.10.2015 / PubMed / Full text
eHealth literacy and Web 2.0 health information seeking behaviors among baby boomers and older adults. / 17.03.2015 / PubMed / Full text
Alterations in the Medullary Endocannabinoid System Contribute to Age-related Impairment of Baroreflex Sensitivity. / 05.2015 / PubMed / Full text
Endogenous leptin contributes to baroreflex suppression within the solitary tract nucleus of aged rats. / 01.12.2014 / PubMed / Full text
Central hydrogen sulphide mediates ventilatory responses to hypercapnia in adult conscious rats. / 11.2014 / PubMed / Full text

OGT

ELT-2 promotes O-GlcNAc transferase OGT-1 expression to modulate Caenorhabditis elegans lifespan. / 06.07.2020 / PubMed / Full text
Neuronal O-GlcNAcylation Improves Cognitive Function in the Aged Mouse Brain. / 21.10.2019 / PubMed / Full text
Schwann cell O-GlcNAcylation promotes peripheral nerve remyelination via attenuation of the AP-1 transcription factor JUN. / 31.07.2018 / PubMed / Full text
O-GlcNAcylation of SKN-1 modulates the lifespan and oxidative stress resistance in Caenorhabditis elegans. / 08.03.2017 / PubMed / Full text
O-linked N-acetylglucosamine transferase (OGT) interacts with the histone chaperone HIRA complex and regulates nucleosome assembly and cellular senescence. / 07.06.2016 / PubMed / Full text
Disruption of O-linked N-Acetylglucosamine Signaling Induces ER Stress and β Cell Failure. / 22.12.2015 / PubMed / Full text
Dietary vitamin D3 improves postprandial hyperglycemia in aged mice. / 22.05.2015 / PubMed / Full text

P2RY12

Potential caveats of putative microglia-specific markers for assessment of age-related cerebrovascular neuroinflammation. / 01.12.2020 / PubMed / Full text
Microglial changes in the early aging stage in a healthy retina and an experimental glaucoma model. / 2020 / PubMed / Full text
Patterns of Expression of Purinergic Receptor P2RY12, a Putative Marker for Non-Activated Microglia, in Aged and Alzheimer's Disease Brains. / 20.01.2020 / PubMed / Full text
Age Influences Microglial Activation After Cuprizone-Induced Demyelination. / 2018 / PubMed / Full text
Dexamethasone Induces a Specific Form of Ramified Dysfunctional Microglia. / 02.2019 / PubMed / Full text
Transcriptomic analysis of purified human cortical microglia reveals age-associated changes. / 08.2017 / PubMed / Full text
Loss of 'homeostatic' microglia and patterns of their activation in active multiple sclerosis. / 01.07.2017 / PubMed / Full text

PCSK9

Lipoprotein removal mechanisms and aging: implications for the cardiovascular health of the elderly. / 04.2020 / PubMed / Full text
The role of proprotein convertase subtilisin-kexin type 9 (PCSK9) in the vascular aging process - is there a link? / 10.2019 / PubMed / Full text
PCSK9 Inhibitors Show Value for Patients and the US Health Care System. / 12.2017 / PubMed / Full text
Association between lipoprotein (a) and proprotein convertase substilisin/kexin type 9 in patients with heterozygous familial hypercholesterolemia: A case-control study. / 02.2018 / PubMed / Full text
What's next for dyslipidemia management? The 2013 ACC/AHA Guidelines, the NLA recommendations, and beyond. / 05-06.2016 / PubMed / Full text
Impact of age and sex on the development of atherosclerosis and expression of the related genes in apoE deficient mice. / 15.01.2016 / PubMed / Full text
[[PCSK9]]: a key modulator of cardiovascular health. / 14.03.2014 / PubMed / Full text

PDK1

Inhibition of 3-phosphoinositide-dependent protein kinase 1 (PDK1) can revert cellular senescence in human dermal fibroblasts. / 08.12.2020 / PubMed / Full text
The Impact of the PI3K/Akt Signaling Pathway in Anxiety and Working Memory in Young and Middle-Aged PDK1 K465E Knock-In Mice. / 2020 / PubMed / Full text
Vps15 is critical to mediate autophagy in AngII treated HUVECs probably by PDK1/PKC signaling pathway. / 15.09.2019 / PubMed / Full text
Acupuncture Administration Improves Cognitive Functions and Alleviates Inflammation and Nuclear Damage by Regulating Phosphatidylinositol 3 Kinase (PI3K)/Phosphoinositol-Dependent Kinase 1 (PDK1)/Novel Protein Kinase C (nPKC)/Rac 1 Signaling Pathway in Senescence-Accelerated Prone 8 (SAM-P8) Mice. / 01.06.2019 / PubMed / Full text
Identification of ATF-7 and the insulin signaling pathway in the regulation of metallothionein in C. elegans suggests roles in aging and reactive oxygen species. / 2017 / PubMed / Full text
Selective deletion of Pten in theca-interstitial cells leads to androgen excess and ovarian dysfunction in mice. / 15.03.2017 / PubMed / Full text
Serine- and threonine/valine-dependent activation of PDK and Tor orthologs converge on Sch9 to promote aging. / 02.2014 / PubMed / Full text

PNN

Hyaluronan degradation and release of a hyaluronan-aggrecan complex from perineuronal nets in the aged mouse brain. / 28.11.2020 / PubMed / Full text
Inhibition of Semaphorin3A Promotes Ocular Dominance Plasticity in the Adult Rat Visual Cortex. / 09.2019 / PubMed / Full text
Proteomics and metabolomics identify molecular mechanisms of aging potentially predisposing for chronic lymphocytic leukemia. / 02.2018 / PubMed / Full text
Age-dependent and region-specific alteration of parvalbumin neurons and perineuronal nets in the mouse cerebral cortex. / 01.2018 / PubMed / Full text
Brain ageing changes proteoglycan sulfation, rendering perineuronal nets more inhibitory. / 28.06.2017 / PubMed / Full text
Removal of Perineuronal Nets Unlocks Juvenile Plasticity Through Network Mechanisms of Decreased Inhibition and Increased Gamma Activity. / 01.02.2017 / PubMed / Full text
Age-Related Deterioration of Perineuronal Nets in the Primary Auditory Cortex of Mice. / 2016 / PubMed / Full text

PSEN1

Genome-wide alteration of 5-hydroxymenthylcytosine in a mouse model of Alzheimer's disease. / 20.05.2016 / PubMed / Full text
White Matter Abnormalities Track Disease Progression in PSEN1 Autosomal Dominant Alzheimer's Disease. / 2016 / PubMed / Full text
Characterization of Amyloid-β Deposits in Bovine Brains. / 2016 / PubMed / Full text
Functions of miR-9 and miR-9* during Aging in SAMP8 Mice and Their Possible Mechanisms. / 06.2015 / PubMed / Full text
DBA/2J genetic background exacerbates spontaneous lethal seizures but lessens amyloid deposition in a mouse model of Alzheimer's disease. / 2015 / PubMed / Full text
Associations between biomarkers and age in the presenilin 1 E280A autosomal dominant Alzheimer disease kindred: a cross-sectional study. / 03.2015 / PubMed / Full text
Age-dependent, non-cell-autonomous deposition of amyloid from synthesis of β-amyloid by cells other than excitatory neurons. / 05.03.2014 / PubMed / Full text

RIG

Protective Effect of Klotho against Ischemic Brain Injury Is Associated with Inhibition of RIG-I/NF-κB Signaling. / 2017 / PubMed / Full text
Aging impairs both primary and secondary RIG-I signaling for interferon induction in human monocytes. / 12.12.2017 / PubMed / Full text
Random Item Generation Is Affected by Age. / 01.10.2016 / PubMed / Full text
Aging-related renal injury and inflammation are associated with downregulation of Klotho and induction of RIG-I/NF-κB signaling pathway in senescence-accelerated mice. / 02.2016 / PubMed / Full text
Age changes of human serum polyreactive immunoglobulins (PRIG) activity. / 09-10.2014 / PubMed / Full text
Global analyses revealed age-related alterations in innate immune responses after stimulation of pathogen recognition receptors. / 06.2015 / PubMed / Full text
Attenuation of respiratory syncytial virus-induced and RIG-I-dependent type I IFN responses in human neonates and very young children. / 01.02.2014 / PubMed / Full text

ROCK1

Disruption of both ROCK1 and ROCK2 genes in cardiomyocytes promotes autophagy and reduces cardiac fibrosis during aging. / 06.2019 / PubMed / Full text
Sonic hedgehog regulation of cavernous nerve regeneration and neurite formation in aged pelvic plexus. / 02.2019 / PubMed / Full text
Vascular Smooth Muscle Contractile Function Declines With Age in Skeletal Muscle Feed Arteries. / 2018 / PubMed / Full text
Reduced corporal fibrosis to protect erectile function by inhibiting the Rho-kinase/LIM-kinase/cofilin pathway in the aged transgenic rat harboring human tissue kallikrein 1. / 01-02.2017 / PubMed / Full text
Rho-associated kinase (ROCK) function is essential for cell cycle progression, senescence and tumorigenesis. / 14.01.2016 / PubMed / Full text
Inverse relationship of Rho kinase and myosin-light chain kinase expression in the aging human detrusor smooth muscle. / 15.10.2015 / PubMed / Full text
miR-135a modulates tendon stem/progenitor cell senescence via suppressing ROCK1. / 02.2015 / PubMed / Full text

SLA

Vaccination of aged mice with adjuvanted recombinant influenza nucleoprotein enhances protective immunity. / 14.07.2020 / PubMed / Full text
Mechanical Anisotropy and Surface Roughness in Additively Manufactured Parts Fabricated by Stereolithography (SLA) Using Statistical Analysis. / 30.05.2020 / PubMed / Full text
The Effect of Age of Titanium Dental Implants on Implant Survival and Marginal Bone Resorption: A 5-Year Retrospective Follow-Up Study. / 01.10.2020 / PubMed / Full text
"Spirometric" lung age reference equations: A narrative review. / 01.2018 / PubMed / Full text
Relative growth rate in phylogenetically related deciduous and evergreen woody species. / 07.2001 / PubMed / Full text
Leaf lifespan as a determinant of leaf structure and function among 23 amazonian tree species. / 03.1991 / PubMed / Full text
The Performance of Titanium-Zirconium Implants in the Elderly: A Biomechanical Comparative Study in the Minipig. / 12.2016 / PubMed / Full text

SLC6A4

The Psilocybin-Telomere Hypothesis: An empirically falsifiable prediction concerning the beneficial neuropsychopharmacological effects of psilocybin on genetic aging. / 01.2020 / PubMed / Full text
Epigenetics-by-sex interaction for somatization conferred by methylation at the promoter region of SLC6A4 gene. / 08.03.2019 / PubMed / Full text
Proteomics and metabolomics identify molecular mechanisms of aging potentially predisposing for chronic lymphocytic leukemia. / 02.2018 / PubMed / Full text
DNA methylation and single nucleotide variants in the brain-derived neurotrophic factor (BDNF) and oxytocin receptor (OXTR) genes are associated with anxiety/depression in older women. / 2015 / PubMed / Full text
Role of the serotonin transporter gene locus in the response to SSRI treatment of major depressive disorder in late life. / 05.2015 / PubMed / Full text
The Impact of Genetics on Physical Resilience and Successful Aging. / 09.2015 / PubMed / Full text
Serotonin transporter polymorphism modifies the association between depressive symptoms and sleep onset latency complaint in elderly people: results from the 'InveCe.Ab' study. / 04.2015 / PubMed / Full text

SNCA

Behavioural and dopaminergic changes in double mutated human A30P*A53T alpha-synuclein transgenic mouse model of Parkinson´s disease. / 22.11.2019 / PubMed / Full text
Reducing INS-IGF1 signaling protects against non-cell autonomous vesicle rupture caused by SNCA spreading. / 05.2020 / PubMed / Full text
SerThr-PhosphoProteome of Brain from Aged PINK1-KO A53T-SNCA Mice Reveals pT1928-MAP1B and pS3781-ANK2 Deficits, as Hub between Autophagy and Synapse Changes. / 04.07.2019 / PubMed / Full text
Age-dependent accumulation of oligomeric SNCA/α-synuclein from impaired degradation in mutant LRRK2 knockin mouse model of Parkinson disease: role for therapeutic activation of chaperone-mediated autophagy (CMA). / 02.2020 / PubMed / Full text
Caloric restriction rescues yeast cells from alpha-synuclein toxicity through autophagic control of proteostasis. / 07.12.2018 / PubMed / Full text
Epigallocatechin-3-gallate increases autophagy signaling in resting and unloaded plantaris muscles but selectively suppresses autophagy protein abundance in reloaded muscles of aged rats. / 06.2017 / PubMed / Full text
DNA methylation levels of α-synuclein intron 1 in the aging brain. / 12.2015 / PubMed / Full text

SOCS3

Congenital Hypothyroidism is Associated With Impairment of the Leptin Signaling Pathway in the Hypothalamus in Male Wistar Animals in Adult Life. / 05.2019 / PubMed / Full text
Deletion of suppressor of cytokine signaling 3 (SOCS3) in muscle stem cells does not alter muscle regeneration in mice after injury. / 2019 / PubMed / Full text
Age-related remodeling of the JAK/STAT/SOCS signaling pathway and associated myocardial changes: From histological to molecular level. / 11.2017 / PubMed / Full text
Gemfibrozil, food and drug administration-approved lipid-lowering drug, increases longevity in mouse model of late infantile neuronal ceroid lipofuscinosis. / 05.2017 / PubMed / Full text
Age-related changes in acute central leptin effects on energy balance are promoted by obesity. / 01.12.2016 / PubMed / Full text
Attenuated heme oxygenase-1 responses predispose the elderly to pulmonary nontuberculous mycobacterial infections. / 01.11.2016 / PubMed / Full text
IL10-driven STAT3 signalling in senescent macrophages promotes pathological eye angiogenesis. / 11.08.2015 / PubMed / Full text

SRC

Metabolic characteristics of CD8 T cell subsets in young and aged individuals are not predictive of functionality. / 05.06.2020 / PubMed / Full text
Overexpression of steroid receptor coactivators alleviates hyperglycemia-induced endothelial cell injury in rats through activating the PI3K/Akt pathway. / 05.2019 / PubMed / Full text
Integrative Analysis of Hippocampus Gene Expression Profiles Identifies Network Alterations in Aging and Alzheimer's Disease. / 2018 / PubMed / Full text
Genetic and Environmental Models of Circadian Disruption Link SRC-2 Function to Hepatic Pathology. / 10.2016 / PubMed / Full text
Conflict-Specific Aging Effects Mainly Manifest in Early Information Processing Stages-An ERP Study with Different Conflict Types. / 2016 / PubMed / Full text
Physical ACtivity facilitation for Elders (PACE): study protocol for a randomised controlled trial. / 13.03.2015 / PubMed / Full text
Investigating the stability of mcDESPOT myelin water fraction values derived using a stochastic region contraction approach. / 01.2015 / PubMed / Full text

SRM

[Geriatric specificities of localized renal cell carcinoma]. / 11.2019 / PubMed / Full text
A targeted proteomic assay for the measurement of plasma proteoforms related to human aging phenotypes. / 08.2017 / PubMed / Full text
The effect of tone-vocoding on spatial release from masking for old, hearing-impaired listeners. / 04.2017 / PubMed / Full text
The role of early and late reflections on spatial release from masking: Effects of age and hearing loss. / 03.2017 / PubMed / Full text
Cortical Measures of Binaural Processing Predict Spatial Release from Masking Performance. / 2017 / PubMed / Full text
Release from masking for small spatial separations: Effects of age and hearing loss. / 07.2016 / PubMed / Full text
Postovulatory aging affects dynamics of mRNA, expression and localization of maternal effect proteins, spindle integrity and pericentromeric proteins in mouse oocytes. / 01.2016 / PubMed / Full text

TRIM59

DNA methylation of the ELOVL2, FHL2, KLF14, C1orf132/MIR29B2C, and TRIM59 genes for age prediction from blood, saliva, and buccal swab samples. / 01.2019 / PubMed / Full text
Proof of concept study of age-dependent DNA methylation markers across different tissues by massive parallel sequencing. / 09.2018 / PubMed / Full text
Chronological age prediction based on DNA methylation: Massive parallel sequencing and random forest regression. / 11.2017 / PubMed / Full text
DNA methylation in ELOVL2 and C1orf132 correctly predicted chronological age of individuals from three disease groups. / 01.2018 / PubMed / Full text
Independent validation of DNA-based approaches for age prediction in blood. / 07.2017 / PubMed / Full text
Donor age and C1orf132/MIR29B2C determine age-related methylation signature of blood after allogeneic hematopoietic stem cell transplantation. / 2016 / PubMed / Full text
Development of a forensically useful age prediction method based on DNA methylation analysis. / 07.2015 / PubMed / Full text

TSC2

AMPK/TSC2/mTOR pathway regulates replicative senescence of human vascular smooth muscle cells. / 12.2018 / PubMed / Full text
Autophagy mediators (FOXO1, SESN3 and TSC2) in Lewy body disease and aging. / 25.09.2018 / PubMed / Full text
FTO is involved in Alzheimer's disease by targeting TSC1-mTOR-Tau signaling. / 25.03.2018 / PubMed / Full text
Postnatal reduction of tuberous sclerosis complex 1 expression in astrocytes and neurons causes seizures in an age-dependent manner. / 12.2017 / PubMed / Full text
Complex inhibition of autophagy by mitochondrial aldehyde dehydrogenase shortens lifespan and exacerbates cardiac aging. / 08.2017 / PubMed / Full text
Longevity and skeletal muscle mass: the role of IGF signalling, the sirtuins, dietary restriction and protein intake. / 08.2015 / PubMed / Full text
Autophagy inhibition switches low-dose camptothecin-induced premature senescence to apoptosis in human colorectal cancer cells. / 01.08.2014 / PubMed / Full text

UCHL1

Abolishing UCHL1's hydrolase activity exacerbates TBI-induced axonal injury and neuronal death in mice. / 04.11.2020 / PubMed / Full text
Role of the Ubiquitin C-Terminal Hydrolase L1-Modulated Ubiquitin Proteasome System in Auditory Cortex Senescence. / 2017 / PubMed / Full text
Life and death in the trash heap: The ubiquitin proteasome pathway and UCHL1 in brain aging, neurodegenerative disease and cerebral Ischemia. / 03.2017 / PubMed / Full text
Amelioration of neuronal cell death in a spontaneous obese rat model by dietary restriction through modulation of ubiquitin proteasome system. / 07.2016 / PubMed / Full text
Effect of age on expression of spermatogonial markers in bovine testis and isolated cells. / 07.2016 / PubMed / Full text
It Is All about (U)biquitin: Role of Altered Ubiquitin-Proteasome System and UCHL1 in Alzheimer Disease. / 2016 / PubMed / Full text
Loss of UCHL1 promotes age-related degenerative changes in the enteric nervous system. / 2014 / PubMed / Full text

VIM

Establishment and characterization of a fibroblast cell line from postmortem skin of an adult Chinese muntjac (Muntiacus reevesi). / 02.2020 / PubMed / Full text
The effect of test modality on dynamic exercise biomarkers in children, adolescents, and young adults. / 07.2019 / PubMed / Full text
Centenarians Overexpress Pluripotency-Related Genes. / 16.08.2019 / PubMed / Full text
Bioinformatics analysis of proteomics profiles in senescent human primary proximal tubule epithelial cells. / 01.04.2016 / PubMed / Full text
Assessment of Age-Related Differences in Functional Capacity Using the Virtual Reality Functional Capacity Assessment Tool (VRFCAT). / 06.2015 / PubMed / Full text
Reactive stroma in the prostate during late life: The role of microvasculature and antiangiogenic therapy influences. / 10.2015 / PubMed / Full text
Cytokinetic Failure-induced Tetraploidy Develops into Aneuploidy, Triggering Skin Aging in Phosphovimentin-deficient Mice. / 22.05.2015 / PubMed / Full text

XIAP

Directed elimination of senescent cells attenuates development of osteoarthritis by inhibition of c-IAP and XIAP. / 01.10.2019 / PubMed / Full text
Modulated electro-hyperthermia induced p53 driven apoptosis and cell cycle arrest additively support doxorubicin chemotherapy of colorectal cancer in vitro. / 08.2019 / PubMed / Full text
Protective effect of xanthohumol against age-related brain damage. / 11.2017 / PubMed / Full text
Molecular modeling in the age of clinical genomics, the enterprise of the next generation. / 03.2017 / PubMed / Full text
Sperm-associated antigen 9 (SPAG9) promotes the survival and tumor growth of triple-negative breast cancer cells. / 10.2016 / PubMed / Full text
XIAP-associating factor 1, a transcriptional target of BRD7, contributes to endothelial cell senescence. / 02.02.2016 / PubMed / Full text
Targeting protein neddylation with an NEDD8-activating enzyme inhibitor MLN4924 induced apoptosis or senescence in human lymphoma cells. / 2015 / PubMed / Full text

ABCA7

New genetic players in late-onset Alzheimer's disease: Findings of genome-wide association studies. / 08.2018 / PubMed / Full text
Whole-Exome Sequencing of an Exceptional Longevity Cohort. / 16.08.2019 / PubMed / Full text
Recent studies on cellular and molecular mechanisms in Alzheimer's disease: focus on epigenetic factors and histone deacetylase. / 28.03.2018 / PubMed / Full text
Late Onset Alzheimer's Disease Risk Variants in Cognitive Decline: The PATH Through Life Study. / 2017 / PubMed / Full text
Association and interaction effects of Alzheimer's disease-associated genes and lifestyle on cognitive aging in older adults in a Taiwanese population. / 11.04.2017 / PubMed / Full text
Gene-based aggregate SNP associations between candidate AD genes and cognitive decline. / 04.2016 / PubMed / Full text

AGA

Relationship between androgenic alopecia and white matter hyperintensities in apparently healthy subjects. / 04.2020 / PubMed / Full text
ALKB-8, a 2-Oxoglutarate-Dependent Dioxygenase and S-Adenosine Methionine-Dependent Methyltransferase Modulates Metabolic Events Linked to Lysosome-Related Organelles and Aging in C. elegans. / 2018 / PubMed
The Impact of Being Born Preterm or Small for Gestational Age on Early Vascular Aging in Adolescents. / 10.2018 / PubMed / Full text
Adult height of preterm infants: a longitudinal cohort study. / 06.2017 / PubMed / Full text
The telomere attrition rate is not accelerated in women born small for gestational age: A birth cohort study. / 05.02.2017 / PubMed / Full text
Does prostaglandin D2 hold the cure to male pattern baldness? / 04.2014 / PubMed / Full text

ALB

Effects of Age on Inflammatory Profiles and Nutrition/Energy Metabolism in Domestic Cats. / 2020 / PubMed / Full text
Blood Chemistry Reference Values for Free-Ranging Asiatic Black Bears ( Ursus thibetanus) by Season, Age, and Sex. / 07.2018 / PubMed / Full text
Higher serum albumin was related with diabetes incidence and the impact of BMI changes: Based on cohort study of 18,384 Chinese male elderly. / 12.2017 / PubMed / Full text
Estimating the survival advantage based on telomere length and serum biomarkers of aging. / 01.08.2017 / PubMed / Full text
HEMATOLOGY AND PLASMA CHEMISTRY OF THE PLOUGHSHARE TORTOISE (ASTROCHELYS YNIPHORA) IN A CAPTIVE BREEDING PROGRAM. / 03.2017 / PubMed / Full text
Too old to have children? Lessons from natural fertility populations. / 06.2014 / PubMed / Full text

AQP1

Blue Light Induces Down-Regulation of Aquaporin 1, 3, and 9 in Human Keratinocytes. / 03.11.2018 / PubMed / Full text
[Age-related changes of water transport by corneal endothelial cells in rats.] / 2017 / PubMed
Investigation of the effects of aging on the expression of aquaporin 1 and aquaporin 4 protein in heart tissue. / 01.2017 / PubMed / Full text
Seasonal and Ageing-Depending Changes of Aquaporins 1 and 9 Expression in the Genital Tract of Buffalo Bulls (Bubalus bubalis). / 08.2016 / PubMed / Full text
Investigation of age-related changes in the expression of aquaporin-1 and aquaporin-5 in the salivary glands of mice. / 09.2016 / PubMed / Full text
The effects of high doses of nandrolone decanoate and exercise on prostate microvasculature of adult and older rats. / 15.01.2015 / PubMed / Full text

ASPA

Effect of adding B-vitamins to vitamin D and calcium supplementation on CpG methylation of epigenetic aging markers. / 04.2018 / PubMed / Full text
Development of a methylation marker set for forensic age estimation using analysis of public methylation data and the Agena Bioscience EpiTYPER system. / 09.2016 / PubMed / Full text
Epigenetic age predictions based on buccal swabs are more precise in combination with cell type-specific DNA methylation signatures. / 05.2016 / PubMed / Full text
Plasma Amyloid Beta 1-42 and DNA Methylation Pattern Predict Accelerated Aging in Young Subjects with Down Syndrome. / 12.2016 / PubMed / Full text
Developing a DNA methylation assay for human age prediction in blood and bloodstain. / 07.2015 / PubMed / Full text
Aging of blood can be tracked by DNA methylation changes at just three CpG sites. / 03.02.2014 / PubMed / Full text

ATRX

ATRX-DAXX Complex Expression Levels and Telomere Length in Normal Young and Elder Autopsy Human Brains. / 09.2019 / PubMed / Full text
Inactivation of hepatic ATRX in [i]Atrx[/i] Foxg1cre mice prevents reversal of aging-like phenotypes by thyroxine. / 07.06.2018 / PubMed / Full text
Mechanistic understanding of the role of ATRX in senescence provides new insight for combinatorial therapies with CDK4 inhibitors. / 2018 / PubMed / Full text
GBM-associated mutations and altered protein expression are more common in young patients. / 25.10.2016 / PubMed / Full text
Postovulatory aging affects dynamics of mRNA, expression and localization of maternal effect proteins, spindle integrity and pericentromeric proteins in mouse oocytes. / 01.2016 / PubMed / Full text
MDM2 turnover and expression of ATRX determine the choice between quiescence and senescence in response to CDK4 inhibition. / 10.04.2015 / PubMed / Full text

BAD

I imidazoline receptor modulation protects aged SAMP8 mice against cognitive decline by suppressing the calcineurin pathway. / 31.10.2020 / PubMed / Full text
Xanthohumol exerts protective effects in liver alterations associated with aging. / 03.2019 / PubMed / Full text
Protective effect of xanthohumol against age-related brain damage. / 11.2017 / PubMed / Full text
Melatonin decreases the expression of inflammation and apoptosis markers in the lung of a senescence-accelerated mice model. / 03.2016 / PubMed / Full text
Melatonin Counteracts at a Transcriptional Level the Inflammatory and Apoptotic Response Secondary to Ischemic Brain Injury Induced by Middle Cerebral Artery Blockade in Aging Rats. / 2015 / PubMed / Full text
Preliminary cognitive scale of basic and instrumental activities of daily living for dementia and mild cognitive impairment. / 2015 / PubMed / Full text

BLM

[Olmesartan inhibits age-associated migration and invasion of human aortic vascular smooth muscle cells by upregulating miR-3133 axis]. / 30.04.2020 / PubMed / Full text
Genomic instability and DNA replication defects in progeroid syndromes. / 31.12.2018 / PubMed / Full text
Human RecQL4 helicase plays multifaceted roles in the genomic stability of normal and cancer cells. / 28.01.2018 / PubMed / Full text
Bloom's syndrome: Why not premature aging?: A comparison of the BLM and WRN helicases. / 01.2017 / PubMed / Full text
NSMCE2 suppresses cancer and aging in mice independently of its SUMO ligase activity. / 03.11.2015 / PubMed / Full text
Senescence induced by RECQL4 dysfunction contributes to Rothmund-Thomson syndrome features in mice. / 15.05.2014 / PubMed / Full text

BMP2

Interleukin-1β-Induced Senescence Promotes Osteoblastic Transition of Vascular Smooth Muscle Cells. / 2020 / PubMed / Full text
Long noncoding RNA Bmncr regulates mesenchymal stem cell fate during skeletal aging. / 03.12.2018 / PubMed / Full text
Synthesis of Extracellular Pyrophosphate Increases in Vascular Smooth Muscle Cells During Phosphate-Induced Calcification. / 09.2018 / PubMed / Full text
Age-Related Insulin-Like Growth Factor Binding Protein-4 Overexpression Inhibits Osteogenic Differentiation of Rat Mesenchymal Stem Cells. / 2017 / PubMed / Full text
p38α MAPK regulates proliferation and differentiation of osteoclast progenitors and bone remodeling in an aging-dependent manner. / 06.04.2017 / PubMed / Full text
Vaccination with DKK1-derived peptides promotes bone formation and bone mass in an aged mouse osteoporosis model. / 08.2014 / PubMed / Full text

BPIFB4

New Insights for BPIFB4 in Cardiovascular Therapy. / 28.09.2020 / PubMed / Full text
LAV-BPIFB4 associates with reduced frailty in humans and its transfer prevents frailty progression in old mice. / 28.08.2019 / PubMed / Full text
Longevity-Associated Variant of BPIFB4 Mitigates Monocyte-Mediated Acquired Immune Response. / 13.11.2019 / PubMed / Full text
A Model of Evolutionary Selection: The Cardiovascular Protective Function of the Longevity Associated Variant of BPIFB4. / 19.10.2018 / PubMed / Full text
The expression of the BPIFB4 and CXCR4 associates with sustained health in long-living individuals from Cilento-Italy. / 22.01.2017 / PubMed / Full text
Genetic Analysis Reveals a Longevity-Associated Protein Modulating Endothelial Function and Angiogenesis. / 31.07.2015 / PubMed / Full text

BRD4

Inhibition of BRD4 triggers cellular senescence through suppressing aurora kinases in oesophageal cancer cells. / 20.09.2020 / PubMed / Full text
BRD4 contributes to LPS-induced macrophage senescence and promotes progression of atherosclerosis-associated lipid uptake. / 11.05.2020 / PubMed / Full text
BET Proteins Are Required for Transcriptional Activation of the Senescent Islet Cell Secretome in Type 1 Diabetes. / 26.09.2019 / PubMed / Full text
Interference with the bromodomain epigenome readers drives p21 expression and tumor senescence. / 01.10.2019 / PubMed / Full text
Neuroprotective effects of targeting BET proteins for degradation with dBET1 in aged mice subjected to ischemic stroke. / 07.2019 / PubMed / Full text
Bromodomain and Extraterminal Protein Inhibition Blocks Growth of Triple-negative Breast Cancers through the Suppression of Aurora Kinases. / 04.11.2016 / PubMed / Full text

CBL

Effects of cerebrolysin on nerve growth factor system in the aging rat brain. / 2017 / PubMed / Full text
Skeletal Muscle CAP Expression Increases after Dietary Restriction and Aerobic Training in Women with a History of Gestational Diabetes. / 2016 / PubMed / Full text
Intranasal Cerebrolysin Attenuates Learning and Memory Impairments in D-galactose-Induced Senescence in Mice. / 01.2017 / PubMed / Full text
Neuroprotective effects of Cerebrolysin in triple repeat Tau transgenic model of Pick's disease and fronto-temporal tauopathies. / 26.11.2015 / PubMed / Full text
Cerebrolysin Accelerates Metamorphosis and Attenuates Aging-Accelerating Effect of High Temperature in Drosophila Melanogaster. / 01.10.2014 / PubMed / Full text
Cerebrolysin™ efficacy in a transgenic model of tauopathy: role in regulation of mitochondrial structure. / 21.07.2014 / PubMed / Full text

CCL20

p53 and p53-related mediators PAI-1 and IGFBP-3 are downregulated in peripheral blood mononuclear cells of HIV-patients exposed to non-nucleoside reverse transcriptase inhibitors. / 06.2020 / PubMed / Full text
Effects of the Consumption of Milk Biofortified with Selenium, Vitamin E, and Different Fatty Acid Profile on Immune Response in the Elderly. / 02.2018 / PubMed / Full text
Human Monocyte Subsets Are Transcriptionally and Functionally Altered in Aging in Response to Pattern Recognition Receptor Agonists. / 15.08.2017 / PubMed / Full text
Interferon-gamma deficiency protects against aging-related goblet cell loss. / 04.10.2016 / PubMed / Full text
Age dependent changes in the LPS induced transcriptome of bovine dermal fibroblasts occurs without major changes in the methylome. / 27.01.2015 / PubMed / Full text
Dendritic cells from aged subjects contribute to chronic airway inflammation by activating bronchial epithelial cells under steady state. / 11.2014 / PubMed / Full text

CCR5

[Enhancement can do harm]. / 08-09.2019 / PubMed / Full text
CCR5-∆32 is deleterious in the homozygous state in humans. / 06.2019 / PubMed / Full text
CCR5 chemokine receptor gene polymorphisms in ocular toxoplasmosis. / 02.2018 / PubMed / Full text
Peripheral loss of CD8( ) CD161( ) TCRVα7·2( ) mucosal-associated invariant T cells in chronic hepatitis C virus-infected patients. / 02.2016 / PubMed / Full text
Increased susceptibility of CD4 T cells from elderly individuals to HIV-1 infection and apoptosis is associated with reduced CD4 and enhanced CXCR4 and FAS surface expression levels. / 09.10.2015 / PubMed / Full text
Aging-associated subpopulations of human CD8 T-lymphocytes identified by their CD28 and CD57 phenotypes. / 11-12.2015 / PubMed / Full text

COL1A1

Remodeling process in bone of aged rats in response to resistance training. / 01.09.2020 / PubMed / Full text
Diet enrichment with a specific essential free amino acid mixture improves healing of undressed wounds in aged rats. / 01.10.2017 / PubMed / Full text
Sirtuin 7 is decreased in pulmonary fibrosis and regulates the fibrotic phenotype of lung fibroblasts. / 01.06.2017 / PubMed / Full text
Scleraxis Is Essential for Tendon Differentiation by Equine Embryonic Stem Cells and in Equine Fetal Tenocytes. / 15.03.2017 / PubMed / Full text
The comparison of microRNA profile of the dermis between the young and elderly. / 05.2016 / PubMed / Full text
Molecular differences between stromal cell populations from deciduous and permanent human teeth. / 18.04.2015 / PubMed / Full text

CPD

Reduced proliferation capacity of lung cells in chronic obstructive pulmonary disease. / 05.2019 / PubMed / Full text
What Do Clinical Supervisors Require to Teach Residents in Family Medicine How to Care for Seniors? / 03.2018 / PubMed / Full text
Survey of Australasian geriatricians' satisfaction with, and preferences for, continuing professional development. / 07.2016 / PubMed / Full text
The aging psychiatrist: lessons from our colleagues in surgery and anaesthesia. / 04.2016 / PubMed / Full text
Effects of donor age and proliferative aging on the phenotype stability of rat aortic smooth muscle cells. / 11.2015 / PubMed / Full text
Specificity of cytochemical and fluorescence methods of senescence-associated β-galactosidase detection for ageing driven by replication and time. / 08.2014 / PubMed / Full text

CSF1R

CSF1R inhibitor PLX5622 and environmental enrichment additively improve metabolic outcomes in middle-aged female mice. / 02.02.2020 / PubMed / Full text
Modulation of Microglia by Voluntary Exercise or CSF1R Inhibition Prevents Age-Related Loss of Functional Motor Units. / 05.11.2019 / PubMed / Full text
Forced turnover of aged microglia induces an intermediate phenotype but does not rebalance CNS environmental cues driving priming to immune challenge. / 26.11.2018 / PubMed / Full text
Replacement of microglia in the aged brain reverses cognitive, synaptic, and neuronal deficits in mice. / 12.2018 / PubMed / Full text
Mendelian adult-onset leukodystrophy genes in Alzheimer's disease: critical influence of CSF1R and NOTCH3. / 06.2018 / PubMed / Full text
Pleiotropic effects of extended blockade of CSF1R signaling in adult mice. / 08.2014 / PubMed / Full text

CYP11A1

Prepubertal exposure to perfluorononanoic acid interferes with spermatogenesis and steroidogenesis in male mice. / 15.04.2019 / PubMed / Full text
Morphological rearrangement of the cortical region, in aging ovaries. / 07.2019 / PubMed / Full text
Peroxiredoxin 2 deficiency accelerates age-related ovarian failure through the reactive oxygen species-mediated JNK pathway in mice. / 01.08.2018 / PubMed / Full text
Systemic analysis of gene expression profiles in porcine granulosa cells during aging. / 14.11.2017 / PubMed / Full text
Combined toxicity of endosulfan and phenanthrene mixtures and induced molecular changes in adult Zebrafish (Danio rerio). / 03.2018 / PubMed / Full text
Testicular gene expression of steroidogenesis-related factors in prepubertal, postpubertal, and aging dogs. / 01.03.2017 / PubMed / Full text

CYP1A2

Impact of Ethnicity-Specific Hepatic Microsomal Scaling Factor, Liver Weight, and Cytochrome P450 (CYP) 1A2 Content on Physiologically Based Prediction of CYP1A2-Mediated Pharmacokinetics in Young and Elderly Chinese Adults. / 07.2019 / PubMed / Full text
Pediatric Cytochrome P450 Activity Alterations in Nonalcoholic Steatohepatitis. / 12.2017 / PubMed / Full text
Analysis of the variability of the pharmacokinetics of multiple drugs in young adult and elderly subjects and its implications for acceptable daily exposures and cleaning validation limits. / 06.2017 / PubMed / Full text
Determination of Human Hepatic CYP2C8 and CYP1A2 Age-Dependent Expression to Support Human Health Risk Assessment for Early Ages. / 05.2017 / PubMed / Full text
Prediction of serum theophylline concentrations and cytochrome P450 1A2 activity by analyzing urinary metabolites in preterm infants. / 06.2017 / PubMed / Full text
[Age-dependent CYP1A2 gene polymorphism -163C>A in three ethnic groups of Bashkortostan Republic residents]. / 2014 / PubMed

CYP2D6

Application of a physiologically based pharmacokinetic model for the prediction of mirabegron plasma concentrations in a population with severe renal impairment. / 05.2019 / PubMed / Full text
[Use of Pharmacogenetic Information for Therapeutic Drug Monitoring of an Antiarrhythmic Drug]. / 2018 / PubMed / Full text
Analysis of the variability of the pharmacokinetics of multiple drugs in young adult and elderly subjects and its implications for acceptable daily exposures and cleaning validation limits. / 06.2017 / PubMed / Full text
Impact of Ageing on Serum Concentrations of Risperidone and Its Active Metabolite in Patients with Known CYP2D6 Genotype. / 11.2016 / PubMed / Full text
Steady-state serum concentrations of venlafaxine in patients with late-life depression. Impact of age, sex and BMI. / 05.2015 / PubMed / Full text
Impact of age on serum concentrations of venlafaxine and escitalopram in different CYP2D6 and CYP2C19 genotype subgroups. / 08.2014 / PubMed / Full text

CYP2E1

DNA methylation and histone acetylation changes to cytochrome P450 2E1 regulation in normal aging and impact on rates of drug metabolism in the liver. / 06.2020 / PubMed / Full text
2, 3, 4', 5-tetrahydroxystilbene-2-0-β-d Glycoside Attenuates Age- and Diet-Associated Non-Alcoholic Steatohepatitis and Atherosclerosis in LDL Receptor Knockout Mice and Its Possible Mechanisms. / 01.04.2019 / PubMed / Full text
Neuroprotective Effect of Dioscin on the Aging Brain. / 30.03.2019 / PubMed / Full text
Cytochrome P450-2E1 is involved in aging-related kidney damage in mice through increased nitroxidative stress. / 11.2017 / PubMed / Full text
Cytochrome P450-2E1 promotes aging-related hepatic steatosis, apoptosis and fibrosis through increased nitroxidative stress. / 02.2016 / PubMed / Full text
Cell type-specific expression and localization of cytochrome P450 isoforms in tridimensional aggregating rat brain cell cultures. / 25.12.2015 / PubMed / Full text

DKK1

Low Serum Levels of DKK2 Predict Incident Low-Impact Fracture in Older Women. / 07.2019 / PubMed / Full text
Involvement of p38 in Age-Related Decline in Adult Neurogenesis via Modulation of Wnt Signaling. / 11.06.2019 / PubMed / Full text
[Role and alterations of DNA methylation during the aging and cancer]. / 01.2018 / PubMed / Full text
Melatonin regulates the aging mouse hippocampal homeostasis via the sirtuin1-FOXO1 pathway. / 2017 / PubMed / Full text
Circulating sclerostin and dickkopf-1 levels in ossification of the posterior longitudinal ligament of the spine. / 05.2016 / PubMed / Full text
Vaccination with DKK1-derived peptides promotes bone formation and bone mass in an aged mouse osteoporosis model. / 08.2014 / PubMed / Full text

FGF19

Bile acid receptor agonists in primary biliary cholangitis: Regulation of the cholangiocyte secretome and downstream T cell differentiation. / 05.2019 / PubMed / Full text
Kotho and aging. / 09.2016 / PubMed
The Klotho proteins in health and disease. / 01.2019 / PubMed / Full text
Peroxisomal Acyl-CoA Oxidase Type 1: Anti-Inflammatory and Anti-Aging Properties with a Special Emphasis on Studies with LPS and Argan Oil as a Model Transposable to Aging. / 2018 / PubMed / Full text
A Genetic Screen Identifies Hypothalamic Fgf15 as a Regulator of Glucagon Secretion. / 08.11.2016 / PubMed / Full text
A preliminary candidate approach identifies the combination of chemerin, fetuin-A, and fibroblast growth factors 19 and 21 as a potential biomarker panel of successful aging. / 06.2015 / PubMed / Full text

FIS1

A mitochondrial FUNDC1/HSC70 interaction organizes the proteostatic stress response at the risk of cell morbidity. / 01.02.2019 / PubMed / Full text
Increased Degradation Rates in the Components of the Mitochondrial Oxidative Phosphorylation Chain in the Cerebellum of Old Mice. / 2018 / PubMed / Full text
Proteomics and metabolomics identify molecular mechanisms of aging potentially predisposing for chronic lymphocytic leukemia. / 02.2018 / PubMed / Full text
Effects of β-hydroxy-β-methylbutyrate on skeletal muscle mitochondrial content and dynamics, and lipids after 10 days of bed rest in older adults. / 01.11.2017 / PubMed / Full text
Mitochondrial activity and dynamics changes regarding metabolism in ageing and obesity. / 03.2017 / PubMed / Full text
Inhibition of peroxisome fission, but not mitochondrial fission, increases yeast chronological lifespan. / 2015 / PubMed / Full text

FMR1

Static and dynamic postural control deficits in aging fragile X mental retardation 1 (FMR1) gene premutation carriers. / 21.01.2019 / PubMed / Full text
Aging in Fragile X Premutation Carriers. / 10.2016 / PubMed / Full text
A Majority of FXTAS Cases Present with Intranuclear Inclusions Within Purkinje Cells. / 10.2016 / PubMed / Full text
Regional brain volumes changes in adult male FMR1-KO mouse on the FVB strain. / 24.03.2016 / PubMed / Full text
FMR1 premutation is an uncommon explanation for premature ovarian failure in Han Chinese. / 2014 / PubMed / Full text
Age and CGG-repeat length are associated with neuromotor impairments in at-risk females with the FMR1 premutation. / 09.2014 / PubMed / Full text

FOXP3

Regulatory T-cells regulate neonatal heart regeneration by potentiating cardiomyocyte proliferation in a paracrine manner. / 2019 / PubMed / Full text
Enhanced expression of PD-1 and other activation markers by CD4 T cells of young but not old patients with metastatic melanoma. / 06.2018 / PubMed / Full text
Non-linear patterns in age-related DNA methylation may reflect CD4 T cell differentiation. / 03.06.2017 / PubMed / Full text
Novel Senescent Regulatory T-Cell Subset with Impaired Suppressive Function in Rheumatoid Arthritis. / 2017 / PubMed / Full text
Age-related changes in CD4 CD25 FOXP3 regulatory T cells and their relationship with lung cancer. / 2017 / PubMed / Full text
Circulating T helper and T regulatory subsets in untreated early rheumatoid arthritis and healthy control subjects. / 10.2016 / PubMed / Full text

GAP43

HDAC inhibition leads to age-dependent opposite regenerative effect upon PTEN deletion in rubrospinal axons after SCI. / 06.2020 / PubMed / Full text
Sonic hedgehog regulation of cavernous nerve regeneration and neurite formation in aged pelvic plexus. / 02.2019 / PubMed / Full text
Differential expression of synaptic and interneuron genes in the aging human prefrontal cortex. / 10.2018 / PubMed / Full text
Schwann Cell Phenotype Changes in Aging Human Dental Pulp. / 03.2018 / PubMed / Full text
Neurexins 1-3 Each Have a Distinct Pattern of Expression in the Early Developing Human Cerebral Cortex. / 01.01.2017 / PubMed / Full text
Alterations of Ca²⁺-responsive proteins within cholinergic neurons in aging and Alzheimer's disease. / 06.2014 / PubMed / Full text

HBP1

Suppression of p38/HBP1 pathway alleviates hyperosmotic stress-induced senescent progression of chondrocyte senescence. / 03-04.2020 / PubMed / Full text
Transcription factor HBP1: A regulator of senescence and apoptosis of preadipocytes. / 17.09.2019 / PubMed / Full text
A positive feedback loop between Pim-1 kinase and HBP1 transcription factor contributes to hydrogen peroxide-induced premature senescence and apoptosis. / 19.05.2017 / PubMed / Full text
Focused screening of mitochondrial metabolism reveals a crucial role for a tumor suppressor Hbp1 in ovarian reserve. / 10.2016 / PubMed / Full text
HBP1-mediated Regulation of p21 Protein through the Mdm2/p53 and TCF4/EZH2 Pathways and Its Impact on Cell Senescence and Tumorigenesis. / 10.06.2016 / PubMed / Full text
Absence of AMPKα2 accelerates cellular senescence via p16 induction in mouse embryonic fibroblasts. / 02.2016 / PubMed / Full text

HCN1

Protein expression changes of HCN1 and HCN2 in hippocampal subregions of gerbils during the normal aging process. / 11.2019 / PubMed / Full text
HCN as a Mediator of Urinary Homeostasis: Age-Associated Changes in Expression and Function in Adrenergic Detrusor Relaxation. / 15.02.2019 / PubMed / Full text
Dopaminergic Neurons Exhibit an Age-Dependent Decline in Electrophysiological Parameters in the MitoPark Mouse Model of Parkinson's Disease. / 06.04.2016 / PubMed / Full text
Characteristics of hyperpolarization-activated cyclic nucleotide-gated channels in dorsal root ganglion neurons at different ages and sizes. / 11.11.2015 / PubMed / Full text
Age-associated expression of HCN channel isoforms in rat sinoatrial node. / 02.2016 / PubMed / Full text
Differential expression of hyperpolarization-activated cyclic nucleotide-gated channel subunits during hippocampal development in the mouse. / 27.02.2015 / PubMed / Full text

IL4

Deficiency in Protein Tyrosine Phosphatase PTP1B Shortens Lifespan and Leads to Development of Acute Leukemia. / 01.01.2018 / PubMed / Full text
Aging Affects Bone Marrow Macrophage Polarization: Relevance to Bone Healing. / 06.2016 / PubMed / Full text
IL4/STAT6 Signaling Activates Neural Stem Cell Proliferation and Neurogenesis upon Amyloid-β42 Aggregation in Adult Zebrafish Brain. / 18.10.2016 / PubMed / Full text
IL10-driven STAT3 signalling in senescent macrophages promotes pathological eye angiogenesis. / 11.08.2015 / PubMed / Full text
LIPID PROFILE AND CYTOKINES INTERACTIONS DURING SUCCESSFUL AGING. / 06.2015 / PubMed
Ageing related periostin expression increase from cardiac fibroblasts promotes cardiomyocytes senescent. / 26.09.2014 / PubMed / Full text

ILK

Age-dependent skeletal muscle transcriptome response to bed rest-induced atrophy. / 01.04.2019 / PubMed / Full text
Hyperphosphatemia Promotes Senescence of Myoblasts by Impairing Autophagy Through Ilk Overexpression, A Possible Mechanism Involved in Sarcopenia. / 10.2018 / PubMed / Full text
Integrin-linked kinase: A new actor in the ageing process? / 15.12.2017 / PubMed / Full text
Hyperphosphatemia induces cellular senescence in human aorta smooth muscle cells through integrin linked kinase (ILK) up-regulation. / 12.2015 / PubMed / Full text
Integrin-linked kinase regulates senescence in an Rb-dependent manner in cancer cell lines. / 2015 / PubMed / Full text
A dual role for integrin-linked kinase and β1-integrin in modulating cardiac aging. / 06.2014 / PubMed / Full text

KEAP1

NRF2 pathway activation by KEAP1 inhibition attenuates the manifestation of aging phenotypes in salivary glands. / 09.2020 / PubMed / Full text
Adaptation of the master antioxidant response connects metabolism, lifespan and feather development pathways in birds. / 18.05.2020 / PubMed / Full text
Inflammatory and Senescent Phenotype of Pancreatic Stellate Cells Induced by Sqstm1 Downregulation Facilitates Pancreatic Cancer Progression. / 2019 / PubMed / Full text
Systemic overexpression of SQSTM1/p62 accelerates disease onset in a SOD1 -expressing ALS mouse model. / 29.05.2018 / PubMed / Full text
Sulfur amino acid restriction-induced changes in redox-sensitive proteins are associated with slow protein synthesis rates. / 04.2018 / PubMed / Full text
The Anti-Aging Effect of Erythropoietin via the ERK/Nrf2-ARE Pathway in Aging Rats. / 03.2017 / PubMed / Full text

MAPK1

Purified Vitexin Compound 1 Inhibits UVA-Induced Cellular Senescence in Human Dermal Fibroblasts by Binding Mitogen-Activated Protein Kinase 1. / 2020 / PubMed / Full text
Identification of key genes and transcription factors in aging mesenchymal stem cells by DNA microarray data. / 15.04.2019 / PubMed / Full text
Integrative Analysis of Hippocampus Gene Expression Profiles Identifies Network Alterations in Aging and Alzheimer's Disease. / 2018 / PubMed / Full text
iTRAQ-based proteomic profiling of granulosa cells from lamb and ewe after superstimulation. / 01.10.2017 / PubMed / Full text
Crosstalk from cAMP to ERK1/2 emerges during postnatal maturation of nociceptive neurons and is maintained during aging. / 01.07.2017 / PubMed / Full text
Maternal immune activation induces changes in myelin and metabolic proteins, some of which can be prevented with risperidone in adolescence. / 2015 / PubMed / Full text

MCU

A rare case of Epstein-Barr virus-positive mucocutaneous ulcer that developed into an intestinal obstruction: a case report. / 13.01.2020 / PubMed / Full text
Inhibition of Mitochondrial Calcium Overload by SIRT3 Prevents Obesity- or Age-Related Whitening of Brown Adipose Tissue. / 02.2020 / PubMed / Full text
Cytosolic and mitochondrial Ca concentrations in primary hepatocytes change with ageing and in consequence of an mtDNA mutation. / 09.2019 / PubMed / Full text
The nuclear receptor RXRA controls cellular senescence by regulating calcium signaling. / 12.2018 / PubMed / Full text
Physical exercise in aging human skeletal muscle increases mitochondrial calcium uniporter expression levels and affects mitochondria dynamics. / 12.2016 / PubMed / Full text
Evolution of increased adult longevity in Drosophila melanogaster populations selected for adaptation to larval crowding. / 02.2016 / PubMed / Full text

MEF2C

Decline in cellular function of aged mouse c-kit cardiac progenitor cells. / 01.10.2017 / PubMed / Full text
Association and interaction effects of Alzheimer's disease-associated genes and lifestyle on cognitive aging in older adults in a Taiwanese population. / 11.04.2017 / PubMed / Full text
Targeted sequencing of genome wide significant loci associated with bone mineral density (BMD) reveals significant novel and rare variants: the Cohorts for Heart and Aging Research in Genomic Epidemiology (CHARGE) targeted sequencing study. / 01.12.2016 / PubMed / Full text
Dynamic Phosphorylation of the Myocyte Enhancer Factor 2Cα1 Splice Variant Promotes Skeletal Muscle Regeneration and Hypertrophy. / 03.2017 / PubMed / Full text
Gene-based aggregate SNP associations between candidate AD genes and cognitive decline. / 04.2016 / PubMed / Full text
Postnatal expression patterns and polymorphism analysis of the bovine myocyte enhancer factor 2C (Mef2C) gene. / 12.2014 / PubMed / Full text

MRE11

Chromosomal alterations among age-related haematopoietic clones in Japan. / 08.2020 / PubMed / Full text
Mechanistic link between DNA damage sensing, repairing and signaling factors and immune signaling. / 2019 / PubMed / Full text
The activated DNA double-strand break repair pathway in cumulus cells from aging patients may be used as a convincing predictor of poor outcomes after in vitro fertilization-embryo transfer treatment. / 2018 / PubMed / Full text
Transactivation domain of p53 regulates DNA repair and integrity in human iPS cells. / 01.09.2018 / PubMed / Full text
BRCA-1 Gene Expression and Comparative Proteomic Profile of Primordial Follicles from Young and Adult Buffalo (Bubalus bubalis) Ovaries. / 03.04.2017 / PubMed / Full text
NBS1 is required for macrophage homeostasis and functional activity in mice. / 26.11.2015 / PubMed / Full text

NES

Mini-review: Aging of the neuroendocrine system: Insights from nonhuman primate models. / 08.06.2020 / PubMed / Full text
Age Dependent Hypothalamic and Pituitary Responses to Novel Environment Stress or Lipopolysaccharide in Rats. / 2018 / PubMed / Full text
[Prediction of life expectancy for prostate cancer patients based on the kinetic theory of aging of living systems]. / 2017 / PubMed
Self-reported Calcium Supplementation and Age-Related Macular Degeneration. / 07.2015 / PubMed / Full text
Association between phosphorus intake and bone health in the NHANES population. / 21.03.2015 / PubMed / Full text
Human induced pluripotent stem cells improve recovery in stroke-injured aged rats. / 2014 / PubMed / Full text

NOS1

Prepubertal overexposure to manganese induce precocious puberty through GABA receptor/nitric oxide pathway in immature female rats. / 30.01.2020 / PubMed / Full text
Genetic background, epigenetic factors and dietary interventions which influence human longevity. / 10.2019 / PubMed / Full text
NOS3 Inhibition Confers Post-Ischemic Protection to Young and Aging White Matter Integrity by Conserving Mitochondrial Dynamics and Miro-2 Levels. / 11.07.2018 / PubMed / Full text
NOS1 and SNAP25 polymorphisms are associated with Attention-Deficit/Hyperactivity Disorder symptoms in adults but not in children. / 04.2016 / PubMed / Full text
NOS1 induces NADPH oxidases and impairs contraction kinetics in aged murine ventricular myocytes. / 09.2015 / PubMed / Full text
Sex-dependent hypertension and renal changes in aged rats with altered renal development. / 15.08.2014 / PubMed / Full text

NOS2

Genetic background, epigenetic factors and dietary interventions which influence human longevity. / 10.2019 / PubMed / Full text
Secreted α-Klotho maintains cartilage tissue homeostasis by repressing [i]NOS2[/i] and [i]ZIP8-MMP13[/i] catabolic axis. / 19.06.2018 / PubMed / Full text
Analysis of molecular networks and targets mining of Chinese herbal medicines on anti-aging. / 28.12.2016 / PubMed / Full text
All-trans retinoic acid (ATRA) prevents lipopolysaccharide-induced neuroinflammation, amyloidogenesis and memory impairment in aged rats. / 15.11.2016 / PubMed / Full text
TNFα antagonization alters NOS2 dependent nasopharyngeal carcinoma tumor growth. / 07.2015 / PubMed / Full text
Bone marrow-derived macrophages from aged rats are more responsive to inflammatory stimuli. / 09.04.2015 / PubMed / Full text

NOTCH1

[How Does Aging Contribute to Cancer?] / 09.2020 / PubMed
H19 is not hypomethylated or upregulated with age or sex in the aortic valves of mice. / 10.2019 / PubMed / Full text
Age-related remodelling of oesophageal epithelia by mutated cancer drivers. / 01.2019 / PubMed / Full text
Dynamic regulation of NOTCH1 activation and Notch ligand expression in human thymus development. / 13.08.2018 / PubMed / Full text
Long telomeres protect against age-dependent cardiac disease caused by NOTCH1 haploinsufficiency. / 01.05.2017 / PubMed / Full text
Candidate gene resequencing to identify rare, pedigree-specific variants influencing healthy aging phenotypes in the long life family study. / 09.04.2016 / PubMed / Full text

PDE4C

Effect of adding B-vitamins to vitamin D and calcium supplementation on CpG methylation of epigenetic aging markers. / 04.2018 / PubMed / Full text
Development of a methylation marker set for forensic age estimation using analysis of public methylation data and the Agena Bioscience EpiTYPER system. / 09.2016 / PubMed / Full text
Plasma Amyloid Beta 1-42 and DNA Methylation Pattern Predict Accelerated Aging in Young Subjects with Down Syndrome. / 12.2016 / PubMed / Full text
Age-associated changes in DNA methylation across multiple tissues in an inbred mouse model. / 03.2016 / PubMed / Full text
Improved age determination of blood and teeth samples using a selected set of DNA methylation markers. / 2015 / PubMed / Full text
Aging of blood can be tracked by DNA methylation changes at just three CpG sites. / 03.02.2014 / PubMed / Full text

PGP

Age-associated changes of the intrinsic nervous system in relation with interstitial cells in the pre-weaning goat rumen. / 14.07.2019 / PubMed / Full text
Changes in the interstitial cells of Cajal and neuronal nitric oxide synthase positive neuronal cells with aging in the esophagus of F344 rats. / 2017 / PubMed / Full text
Change in the Interstitial Cells of Cajal and nNOS Positive Neuronal Cells with Aging in the Stomach of F344 Rats. / 2017 / PubMed / Full text
The matrikine N-acetylated proline-glycine-proline induces premature senescence of nucleus pulposus cells via CXCR1-dependent ROS accumulation and DNA damage and reinforces the destructive effect of these cells on homeostasis of intervertebral discs. / 01.2017 / PubMed / Full text
[CHANGES IN THE PANCREATIC ISLETS AND NERVOUS ELEMENTS IN RATS DURING AGING (AN IMMUNOHISTOCHEMICAL STUDY)]. / 2015 / PubMed
Associations between xerostomia, histopathological alterations, and autonomic innervation of labial salivary glands in men in late midlife. / 09.2014 / PubMed / Full text

PIK3CA

Myocyte enhancer factor 2A delays vascular endothelial cell senescence by activating the PI3K/p-Akt/SIRT1 pathway. / 10.06.2019 / PubMed / Full text
Oncogenic mutations in histologically normal endometrium: the new normal? / 10.2019 / PubMed / Full text
A clinical trial of somatic and germline analyses for healthy longevity in a postoperative cancer patient. / 09.2019 / PubMed / Full text
Membrane metallo-endopeptidase mediates cellular senescence induced by oncogenic PIK3CA accompanied with pro-tumorigenic secretome. / 01.08.2019 / PubMed / Full text
Therapeutic and preventive effects of exercise on cardiometabolic parameters in aging and obese rats. / 02.2019 / PubMed / Full text
Coordinated Expression of Phosphoinositide Metabolic Genes during Development and Aging of Human Dorsolateral Prefrontal Cortex. / 2015 / PubMed / Full text

PON1

Paraoxonases Activities and Polymorphisms in Elderly and Old-Age Diseases: An Overview. / 02.05.2019 / PubMed / Full text
The role of paraoxonase 1 in regulating high-density lipoprotein functionality during aging. / 10.2017 / PubMed / Full text
Advanced glycation end products affect cholesterol homeostasis by impairing ABCA1 expression on macrophages. / 08.2017 / PubMed / Full text
Paraoxonase-1 (PON1) rs662 Polymorphism and Its Association with Serum Lipid Levels and Longevity in the Bama Zhuang Population. / 27.12.2016 / PubMed / Full text
Differential effects of a high-fat diet on serum lipid parameters and ovarian gene expression in young and aged female mice. / 10.2016 / PubMed / Full text
Paraoxonase (PON1) polymorphisms Q192R and L55M are not associated with human longevity: A meta-analysis. / 01.2016 / PubMed / Full text

POR

The Ventricular System Enlarges Abnormally in the Seventies, Earlier in Men, and First in the Frontal Horn: A Study Based on More Than 3,000 Scans. / 2019 / PubMed / Full text
Clinical findings associated with development of postoperative reflux and short-term survival after small intestinal surgery in geriatric and mature nongeriatric horses. / 07.2019 / PubMed / Full text
Effect of Age and Allele Variants of CYP3A5, CYP3A4, and POR Genes on the Pharmacokinetics of Cyclosporin A in Pediatric Renal Transplant Recipients From Serbia. / 12.2017 / PubMed / Full text
Phosphorylation of WHIRLY1 by CIPK14 Shifts Its Localization and Dual Functions in Arabidopsis. / 01.05.2017 / PubMed / Full text
Endometriosis has no negative impact on outcomes of in vitro fertilisation in women with poor ovarian response. / 09.2016 / PubMed / Full text
Short-term complications after colic surgery in geriatric versus mature non-geriatric horses. / 02.2015 / PubMed / Full text

PPID

Relationships of inflamm-aging with circulating nutrient levels, body composition, age, and pituitary pars intermedia dysfunction in a senior horse population. / 03.2020 / PubMed / Full text
Epidemiology of pituitary pars intermedia dysfunction: A systematic literature review of clinical presentation, disease prevalence and risk factors. / 05.2018 / PubMed / Full text
Effect of Age, Season, Body Condition, and Endocrine Status on Serum Free Cortisol Fraction and Insulin Concentration in Horses. / 03-04.2016 / PubMed / Full text
Age-related Qualitative Histological and Quantitative Stereological Changes in the Equine Pituitary. / 02-04.2016 / PubMed / Full text
What's New in Old Horses? Postmortem Diagnoses in Mature and Aged Equids. / 03.2016 / PubMed / Full text
Pituitary pars intermedia dysfunction does not necessarily impair insulin sensitivity in old horses. / 01.2015 / PubMed / Full text

RAD50

Transactivation domain of p53 regulates DNA repair and integrity in human iPS cells. / 01.09.2018 / PubMed / Full text
Phosphorylation of WHIRLY1 by CIPK14 Shifts Its Localization and Dual Functions in Arabidopsis. / 01.05.2017 / PubMed / Full text
HIF-1α and rapamycin act as gerosuppressant in multiple myeloma cells upon genotoxic stress. / 17.08.2016 / PubMed / Full text
Immunochip analysis identifies association of the RAD50/IL13 region with human longevity. / 06.2016 / PubMed / Full text
Causal mechanisms and balancing selection inferred from genetic associations with polycystic ovary syndrome. / 29.09.2015 / PubMed / Full text
Targeting of DNA Damage Signaling Pathway Induced Senescence and Reduced Migration of Cancer cells. / 06.2015 / PubMed / Full text

RIPK1

Casein kinase 1G2 suppresses necroptosis-promoted testis aging by inhibiting receptor-interacting kinase 3. / 18.11.2020 / PubMed / Full text
Crucial role of the terminal complement complex in chondrocyte death and hypertrophy after cartilage trauma. / 05.2020 / PubMed / Full text
RIP kinases as modulators of inflammation and immunity. / 09.2018 / PubMed / Full text
TBK1 Suppresses RIPK1-Driven Apoptosis and Inflammation during Development and in Aging. / 06.09.2018 / PubMed / Full text
Necroptosis increases with age and is reduced by dietary restriction. / 08.2018 / PubMed / Full text
RIPK1-RIPK3-MLKL-dependent necrosis promotes the aging of mouse male reproductive system. / 15.08.2017 / PubMed / Full text

RUNX1

RUNX-mediated growth arrest and senescence are attenuated by diverse mechanisms in cells expressing RUNX1 fusion oncoproteins. / 03.2018 / PubMed / Full text
Sequential acquisition of mutations in myelodysplastic syndromes. / 2017 / PubMed / Full text
Conversion of adult endothelium to immunocompetent haematopoietic stem cells. / 25.05.2017 / PubMed / Full text
Resistance Training Enhances Skeletal Muscle Innervation Without Modifying the Number of Satellite Cells or their Myofiber Association in Obese Older Adults. / 10.2016 / PubMed / Full text
Epigenetic Aging Signatures Are Coherently Modified in Cancer. / 06.2015 / PubMed / Full text
Microglia recapitulate a hematopoietic master regulator network in the aging human frontal cortex. / 08.2015 / PubMed / Full text

SHH

Recent advances in SHH medulloblastoma progression: tumor suppressor mechanisms and the tumor microenvironment. / 2019 / PubMed / Full text
An Endogenous Anti-aging Factor, Sonic Hedgehog, Suppresses Endometrial Stem Cell Aging through SERPINB2. / 03.07.2019 / PubMed / Full text
Sonic hedgehog regulation of cavernous nerve regeneration and neurite formation in aged pelvic plexus. / 02.2019 / PubMed / Full text
Evasion of cell senescence in SHH medulloblastoma. / 17.08.2016 / PubMed / Full text
Expression and Role of Sonic Hedgehog in the Process of Fracture Healing with Aging. / 03-04.2016 / PubMed
The Subjective Health Horizon Questionnaire (SHH-Q): Assessing Future Time Perspectives for Facets of an Active Lifestyle. / 2016 / PubMed / Full text

SMAD2

Prostate epithelial-specific expression of activated PI3K drives stromal collagen production and accumulation. / 02.2020 / PubMed / Full text
Restoring extracellular matrix synthesis in senescent stem cells. / 10.2019 / PubMed / Full text
iTRAQ-based proteomic profiling of granulosa cells from lamb and ewe after superstimulation. / 01.10.2017 / PubMed / Full text
Exogenous GDF11 induces cardiac and skeletal muscle dysfunction and wasting. / 07.2017 / PubMed / Full text
Circulating Growth Differentiation Factor 11/8 Levels Decline With Age. / 08.01.2016 / PubMed / Full text
Effects of aging on cardiac extracellular matrix in men and women. / 01.2016 / PubMed / Full text

SOD3

Prenatal hypoxia affected endothelium-dependent vasodilation in mesenteric arteries of aged offspring via increased oxidative stress. / 06.2019 / PubMed / Full text
Superoxide dismutase activity is significantly lower in end-stage osteoarthritic cartilage than non-osteoarthritic cartilage. / 2018 / PubMed / Full text
In silico analysis and molecular dynamics simulation of human superoxide dismutase 3 (SOD3) genetic variants. / 03.2019 / PubMed / Full text
Proteomic profiling of follicle fluids after superstimulation in one-month-old lambs. / 02.2018 / PubMed / Full text
Molecular evolutionary patterns of NAD /Sirtuin aging signaling pathway across taxa. / 2017 / PubMed / Full text
Extracellular superoxide dismutase deficiency impairs wound healing in advanced age by reducing neovascularization and fibroblast function. / 03.2016 / PubMed / Full text

SSB

Modelling the Effects of Beverage Substitution during Adolescence on Later Obesity Outcomes in Early Adulthood: Results from the Raine Study. / 03.12.2019 / PubMed / Full text
WHIRLY1 Occupancy Affects Histone Lysine Modification and [i]WRKY53[/i] Transcription in [i]Arabidopsis[/i] Developmental Manner. / 2018 / PubMed / Full text
Modelled health benefits of a sugar-sweetened beverage tax across different socioeconomic groups in Australia: A cost-effectiveness and equity analysis. / 06.2017 / PubMed / Full text
Reduction of Sugar-Sweetened Beverage Consumption in Elementary School Students Using an Educational Curriculum of Beverage Sugar Content. / 2017 / PubMed / Full text
Interannual and Spatial Variability in Maturity of Walleye Pollock Gadus chalcogrammus and Implications for Spawning Stock Biomass Estimates in the Gulf of Alaska. / 2016 / PubMed / Full text
Age dynamics of DNA damage and CpG methylation in the peripheral blood leukocytes of mice. / 05.2015 / PubMed / Full text

TIGIT

Impaired Cytolytic Activity and Loss of Clonal Neoantigens in Elderly Patients With Lung Adenocarcinoma. / 05.2019 / PubMed / Full text
Multivariate Computational Analysis of Gamma Delta T Cell Inhibitory Receptor Signatures Reveals the Divergence of Healthy and ART-Suppressed HIV Aging. / 2018 / PubMed / Full text
Characterization of Blimp-1 function in effector regulatory T cells. / 07.2018 / PubMed / Full text
T-cell Immunoglobulin and ITIM Domain Contributes to CD8 T-cell Immunosenescence. / 04.2018 / PubMed / Full text
Long-Lived CD4 IFN-γ T Cells rather than Short-Lived CD4 IFN-γ IL-10 T Cells Initiate Rapid IL-10 Production To Suppress Anamnestic T Cell Responses during Secondary Malaria Infection. / 15.10.2016 / PubMed / Full text
Combinatorial approach to cancer immunotherapy: strength in numbers. / 08.2016 / PubMed / Full text

TIMP1

Design, cyclization, and optimization of MMP13-TIMP1 interaction-derived self-inhibitory peptides against chondrocyte senescence in osteoarthritis. / 01.2019 / PubMed / Full text
Retinoic acid promotes in vitro follicle activation in the cat ovary by regulating expression of matrix metalloproteinase 9. / 2018 / PubMed / Full text
Timing and duration of nursing from birth affect neonatal porcine uterine matrix metalloproteinase 9 and tissue inhibitor of metalloproteinase 1. / 04.2017 / PubMed / Full text
Effect of TIMP1 transfection on PTEN expression in human kidney proximal tubular cells. / 21.12.2015 / PubMed / Full text
Biological Effects Induced by Specific Advanced Glycation End Products in the Reconstructed Skin Model of Aging. / 2015 / PubMed / Full text
Fat and Sucrose Intake Induces Obesity-Related Bone Metabolism Disturbances: Kinetic and Reversibility Studies in Growing and Adult Rats. / 01.2016 / PubMed / Full text

TPO

Megakaryocytes promote osteoclastogenesis in aging. / 07.07.2020 / PubMed / Full text
To reflect human autoimmune thyroiditis, thyroid peroxidase (not thyroglobulin) antibodies should be measured in female (not sex-independent) NOD.H2 mice. / 04.2019 / PubMed / Full text
Kras is Required for Adult Hematopoiesis. / 07.2016 / PubMed / Full text
Signal for Thrombosis with Eltrombopag and Romiplostim: A Disproportionality Analysis of Spontaneous Reports Within VigiBase®. / 12.2015 / PubMed / Full text
Effect of different photoinitiators and reducing agents on cure efficiency and color stability of resin-based composites using different LED wavelengths. / 12.2015 / PubMed / Full text
Complex reference value distributions and partitioned reference intervals across the pediatric age range for 14 specialized biochemical markers in the CALIPER cohort of healthy community children and adolescents. / 23.10.2015 / PubMed / Full text

TPP1

FBW7 Mediates Senescence and Pulmonary Fibrosis through Telomere Uncapping. / 03.11.2020 / PubMed / Full text
Gemfibrozil, food and drug administration-approved lipid-lowering drug, increases longevity in mouse model of late infantile neuronal ceroid lipofuscinosis. / 05.2017 / PubMed / Full text
Shelterin Telomere Protection Protein 1 Reduction Causes Telomere Attrition and Cellular Senescence via Sirtuin 1 Deacetylase in Chronic Obstructive Pulmonary Disease. / 01.2017 / PubMed / Full text
Increased expression of telomere-regulating genes in endurance athletes with long leukocyte telomeres. / 15.01.2016 / PubMed / Full text
SIRT1 ameliorates age-related senescence of mesenchymal stem cells via modulating telomere shelterin. / 2014 / PubMed / Full text
Essential role for the TRF2 telomere protein in adult skin homeostasis. / 08.2014 / PubMed / Full text

TRA

MYC Releases Early Reprogrammed Human Cells from Proliferation Pause via Retinoblastoma Protein Inhibition. / 10.04.2018 / PubMed / Full text
Sex-specific regulation of aging in Caenorhabditis elegans. / 06.2018 / PubMed / Full text
Age-Associated Decline in Thymic B Cell Expression of Aire and Aire-Dependent Self-Antigens. / 30.01.2018 / PubMed / Full text
[Research of anti-aging mechanism of ginsenoside Rg1 on brain]. / 11.2014 / PubMed
Post-mortem findings and piglet mortality in relation to strategic use of straw at farrowing. / 01.05.2015 / PubMed / Full text
TDP-43 toxicity proceeds via calcium dysregulation and necrosis in aging Caenorhabditis elegans motor neurons. / 03.09.2014 / PubMed / Full text

XPC

MicroRNA binding mediated Functional sequence variant in 3'-UTR of DNA repair Gene XPC in Age-related Cataract. / 12.10.2018 / PubMed / Full text
Global-genome Nucleotide Excision Repair Controlled by Ubiquitin/Sumo Modifiers. / 2016 / PubMed / Full text
Xeroderma pigmentosum group C sensor: unprecedented recognition strategy and tight spatiotemporal regulation. / 02.2016 / PubMed / Full text
Lifespan and Stress Resistance in Drosophila with Overexpressed DNA Repair Genes. / 19.10.2015 / PubMed / Full text
[Role of DNA repair genes in radiation-induced changes of lifespan of Drosophila melanogaster]. / 09-10.2014 / PubMed
Defective mitophagy in XPA via PARP-1 hyperactivation and NAD( )/SIRT1 reduction. / 08.05.2014 / PubMed / Full text

YAP1

[Expression relationship of Hippo signaling molecules and ovarian germline stem cell markers in the ovarian aging process of women and mice]. / 25.06.2019 / PubMed
YAP1-LATS2 feedback loop dictates senescent or malignant cell fate to maintain tissue homeostasis. / 03.2019 / PubMed / Full text
Extended Multiplexing of Tandem Mass Tags (TMT) Labeling Reveals Age and High Fat Diet Specific Proteome Changes in Mouse Epididymal Adipose Tissue. / 05.2017 / PubMed / Full text
Impaired liver regeneration in aged mice can be rescued by silencing Hippo core kinases MST1 and MST2. / 01.2017 / PubMed / Full text
Temporal and spatial expression of Smads and their correlation with YAP1 expression in sheep. / 26.08.2016 / PubMed / Full text
Causal mechanisms and balancing selection inferred from genetic associations with polycystic ovary syndrome. / 29.09.2015 / PubMed / Full text

ABCA1

Intracellular cholesterol stimulates ENaC by interacting with phosphatidylinositol‑4,5‑bisphosphate and mediates cyclosporine A-induced hypertension. / 01.07.2019 / PubMed / Full text
Disrupted cholesterol metabolism promotes age-related photoreceptor neurodegeneration. / 08.2018 / PubMed / Full text
Advanced glycation end products affect cholesterol homeostasis by impairing ABCA1 expression on macrophages. / 08.2017 / PubMed / Full text
Genome-wide DNA methylation profiles reveal novel candidate genes associated with meat quality at different age stages in hens. / 05.04.2017 / PubMed / Full text
Impact of age and sex on the development of atherosclerosis and expression of the related genes in apoE deficient mice. / 15.01.2016 / PubMed / Full text

ABCG2

Contribution of senescence in human endometrial stromal cells during proliferative phase to embryo receptivity†. / 23.06.2020 / PubMed / Full text
ABCG2 rs2231142 variant in hyperuricemia is modified by SLC2A9 and SLC22A12 polymorphisms and cardiovascular risk factors in an elderly community-dwelling population. / 17.03.2020 / PubMed / Full text
Morphological and immunohistochemical characteristics of the equine corneal epithelium. / 11.2019 / PubMed / Full text
Proteomic Analysis of the Developmental Trajectory of Human Hepatic Membrane Transporter Proteins in the First Three Months of Life. / 07.2016 / PubMed / Full text
Gene specific epigenetic regulation of hepatic folate transport system is responsible for perturbed cellular folate status during aging and exogenous modulation. / 06.2016 / PubMed / Full text

AIM2

Papilloma-pseudovirus eradicates intestinal tumours and triples the lifespan of Apc mice. / 11.04.2017 / PubMed / Full text
Reduced levels of cytosolic DNA sensor AIM2 are associated with impaired cytokine responses in healthy elderly. / 06.2016 / PubMed / Full text
Gene expression of inflammasome components in peripheral blood mononuclear cells (PBMC) of vascular patients increases with age. / 2015 / PubMed / Full text
Effects of aging in the expression of NOD-like receptors and inflammasome-related genes in oral mucosa. / 02.2016 / PubMed / Full text
DAMPs, ageing, and cancer: The 'DAMP Hypothesis'. / 11.2015 / PubMed / Full text

ARMS2

Benefits, Potential Harms, and Optimal Use of Nutritional Supplementation for Preventing Progression of Age-Related Macular Degeneration. / 03.2017 / PubMed / Full text
A Phenotyping Regimen for Genetically Modified Mice Used to Study Genes Implicated in Human Diseases of Aging. / 14.07.2016 / PubMed / Full text
Mesopic Pelli-Robson contrast sensitivity and MP-1 microperimetry in healthy ageing and age-related macular degeneration. / 12.2016 / PubMed / Full text
[Age-related Macular Degeneration in the Japanese]. / 03.2016 / PubMed
Prevalence and Genetic Characteristics of Geographic Atrophy among Elderly Japanese with Age-Related Macular Degeneration. / 2016 / PubMed / Full text

ASXL1

ASXL1 mutation in clonal hematopoiesis. / 03.2020 / PubMed / Full text
[Role of ASXL1 mutations in hematological disorders]. / 2019 / PubMed / Full text
Clonal hematopoiesis: Genes and underlying mechanisms in cardiovascular disease development. / 06.2019 / PubMed / Full text
A primer for epigenetics of hematological malignancies. / 2016 / PubMed / Full text
The BAP1/ASXL2 Histone H2A Deubiquitinase Complex Regulates Cell Proliferation and Is Disrupted in Cancer. / 27.11.2015 / PubMed / Full text

BID

Dabigatran etexilate: appropriate use in patients with chronic kidney disease and in the elderly patients. / 06.2017 / PubMed / Full text
Sperm-associated antigen 9 (SPAG9) promotes the survival and tumor growth of triple-negative breast cancer cells. / 10.2016 / PubMed / Full text
Rationale for the Assessment of Metoprolol in the Prevention of Vasovagal Syncope in Aging Subjects Trial (POST5). / 04.2016 / PubMed / Full text
The geriatric mania asenapine study (GeMS). / 05-06.2016 / PubMed / Full text
The effect of aging on mitochondrial and cytosolic hepatic intrinsic death pathway and apoptosis associated proteins in Fischer 344 rats. / 07.2015 / PubMed / Full text

CCR6

Age-associated antigen-presenting cell alterations promote dry-eye inducing Th1 cells. / 07.2019 / PubMed / Full text
Age-related but not longevity-related genes are found by weighted gene co-expression network analysis in the peripheral blood cells of humans. / 19.01.2019 / PubMed / Full text
Circulating T helper and T regulatory subsets in untreated early rheumatoid arthritis and healthy control subjects. / 10.2016 / PubMed / Full text
Double negative (IgG IgD-CD27-) B cells are increased in a cohort of moderate-severe Alzheimer's disease patients and show a pro-inflammatory trafficking receptor phenotype. / 2015 / PubMed / Full text
Trafficking phenotype and production of granzyme B by double negative B cells (IgG( )IgD(-)CD27(-)) in the elderly. / 06.2014 / PubMed / Full text

CD2AP

Recent studies on cellular and molecular mechanisms in Alzheimer's disease: focus on epigenetic factors and histone deacetylase. / 28.03.2018 / PubMed / Full text
Association and interaction effects of Alzheimer's disease-associated genes and lifestyle on cognitive aging in older adults in a Taiwanese population. / 11.04.2017 / PubMed / Full text
Gene-based aggregate SNP associations between candidate AD genes and cognitive decline. / 04.2016 / PubMed / Full text
HYDRA: Revealing heterogeneity of imaging and genetic patterns through a multiple max-margin discriminative analysis framework. / 15.01.2017 / PubMed / Full text
Dendrin ablation prolongs life span by delaying kidney failure. / 08.2015 / PubMed / Full text

CD74

Identification of a conserved gene signature associated with an exacerbated inflammatory environment in the hippocampus of aging rats. / 04.2017 / PubMed / Full text
Intramembrane proteolysis within lysosomes. / 12.2016 / PubMed / Full text
Proton irradiation impacts age-driven modulations of cancer progression influenced by immune system transcriptome modifications from splenic tissue. / 09.2015 / PubMed / Full text
Macrophage migration inhibitory factor confers resistance to senescence through CD74-dependent AMPK-FOXO3a signaling in mesenchymal stem cells. / 22.04.2015 / PubMed / Full text
Macrophage migration inhibitory factor deficiency in chronic obstructive pulmonary disease. / 15.03.2014 / PubMed / Full text

CDC42

Effects of age-dependent changes in cell size on endothelial cell proliferation and senescence through YAP1. / 05.09.2019 / PubMed / Full text
Re-exploring the core genes and modules in the human frontal cortex during chronological aging: insights from network-based analysis of transcriptomic studies. / 20.10.2018 / PubMed / Full text
The relationship between reproductive and biochemical ageing at the time of the menopausal transition. / 11.2017 / PubMed / Full text
Senescent cells communicate via intercellular protein transfer. / 15.04.2015 / PubMed / Full text
A crucial role for CDC42 in senescence-associated inflammation and atherosclerosis. / 2014 / PubMed / Full text

CTNNB1

[i]TP53[/i] Tumor-suppressor Gene Plays a Key Role in IGF1 Signaling Pathway Related to the Aging of Human Melanocytes. / 05.2019 / PubMed / Full text
Identification of key genes and transcription factors in aging mesenchymal stem cells by DNA microarray data. / 15.04.2019 / PubMed / Full text
Proteomic profiling of follicle fluids after superstimulation in one-month-old lambs. / 02.2018 / PubMed / Full text
P4 medicine and osteoporosis: a systematic review. / 12.2016 / PubMed / Full text
Expression profile analysis of new candidate genes for the therapy of primary osteoporosis. / 2016 / PubMed

DLD

A preliminary study of cerebral blood flow, aging and dementia in people with Down syndrome. / 12.2020 / PubMed / Full text
Premature senescence activation in DLD-1 colorectal cancer cells through adjuvant therapy to induce a miRNA profile modulating cellular death. / 08.2018 / PubMed / Full text
Immature Auditory Evoked Potentials in Children With Moderate-Severe Developmental Language Disorder. / 13.07.2018 / PubMed / Full text
Trifluridine/tipiracil increases survival rates in peritoneal dissemination mouse models of human colorectal and gastric cancer. / 07.2017 / PubMed / Full text
Age dynamics of DNA damage and CpG methylation in the peripheral blood leukocytes of mice. / 05.2015 / PubMed / Full text

DSP

Noradrenergic dysfunction accelerates LPS-elicited inflammation-related ascending sequential neurodegeneration and deficits in non-motor/motor functions. / 10.2019 / PubMed / Full text
Trade-offs in aging lung diseases: a review on shared but opposite genetic risk variants in idiopathic pulmonary fibrosis, lung cancer and chronic obstructive pulmonary disease. / 05.2018 / PubMed / Full text
Metabolic Syndrome Components Are Associated With Symptomatic Polyneuropathy Independent of Glycemic Status. / 05.2016 / PubMed / Full text
Analysis of diarrhetic shellfish poisoning toxins and pectenotoxin-2 in the bottlenose dolphin (Tursiops truncatus) by liquid chromatography-tandem mass spectrometry. / 16.10.2015 / PubMed / Full text
Telomere position effect: regulation of gene expression with progressive telomere shortening over long distances. / 15.11.2014 / PubMed / Full text

ERAS

Enhanced Recovery After Surgery: Are the Principles Applicable to Adult and Geriatric Acute Care and Trauma Surgery? / 03.2019 / PubMed / Full text
Prospective application of an implementation framework to improve postoperative nutrition care processes: Evaluation of a mixed methods implementation study. / 09.2018 / PubMed / Full text
Enhanced Recovery After Surgery (ERAS) - The Evidence in Geriatric Emergency Surgery: A Systematic Review. / Sept-10.2017 / PubMed / Full text
Multimodal Rehabilitation in Geriatric Emergency Surgery. / Sept-10.2017 / PubMed / Full text
Surgical Stress Reduction in Elderly Patients Undergoing Elective Colorectal Laparoscopic Surgery within an ERAS Protocol. / 11-12.2016 / PubMed / Full text

ESR1

Menopause and adipose tissue: miR-19a-3p is sensitive to hormonal replacement. / 05.01.2018 / PubMed / Full text
Inter-Regional Variations in Gene Expression and Age-Related Cortical Thinning in the Adolescent Brain. / 01.04.2018 / PubMed / Full text
Age- and menopause-related differences in subcutaneous adipose tissue estrogen receptor mRNA expression. / 05.2017 / PubMed / Full text
Association of PvuII and XbaI polymorphisms on estrogen receptor alpha (ESR1) gene to changes into serum lipid profile of post-menopausal women: Effects of aging, body mass index and breast cancer incidence. / 2017 / PubMed / Full text
Differential roles of estrogen receptors, ESR1 and ESR2, in adult rat spermatogenesis. / 15.06.2016 / PubMed / Full text

FADD

Improved age-related deficits in cognitive performance and affective-like behavior following acute, but not repeated, 8-OH-DPAT treatments in rats: regulation of hippocampal FADD. / 11.2018 / PubMed / Full text
Decreased cortical FADD protein is associated with clinical dementia and cognitive decline in an elderly community sample. / 20.03.2017 / PubMed / Full text
Chronic MDMA induces neurochemical changes in the hippocampus of adolescent and young adult rats: Down-regulation of apoptotic markers. / 07.2015 / PubMed / Full text
The Heart Protection Effect of Alcalase Potato Protein Hydrolysate Is through IGF1R-PI3K-Akt Compensatory Reactivation in Aging Rats on High Fat Diets. / 05.05.2015 / PubMed / Full text
TNF/TNFR₁ pathway and endoplasmic reticulum stress are involved in ofloxacin-induced apoptosis of juvenile canine chondrocytes. / 15.04.2014 / PubMed / Full text

FGA

Goal Pursuit, Goal Adjustment, and Pain in Middle-Aged Adults Aging With Physical Disability. / 12.2019 / PubMed / Full text
Tenacious Goal Pursuit, Flexible Goal Adjustment, and Life Satisfaction Among Chinese Older Adult Couples. / 01.2020 / PubMed / Full text
Association of tenacious goal pursuit and flexible goal adjustment with out-of-home mobility among community-dwelling older people. / 09.2019 / PubMed / Full text
Assimilative and accommodative coping in older adults with and without sensory impairment: four-year change and prospective relations with affective well-being. / 09.2019 / PubMed / Full text
Age stereotypes, flexible goal adjustment, and well-being among Chinese older adults. / 02.2018 / PubMed / Full text

FGR

Aurora kinase mRNA expression is reduced with increasing gestational age and in severe early onset fetal growth restriction. / 06.2020 / PubMed / Full text
Premature Vascular Aging in Guinea Pigs Affected by Fetal Growth Restriction. / 15.07.2019 / PubMed / Full text
Premature placental aging in term small-for-gestational-age and growth-restricted fetuses. / 05.2019 / PubMed / Full text
The effect of fertility treatment on adverse perinatal outcomes in women aged at least 40 years. / 01.2018 / PubMed / Full text
Seroprevalence of spotted fever group Rickettsiae in dogs in Germany. / 03.2015 / PubMed / Full text

FOXA1

Analyses of an epigenetic switch involved in the activation of pioneer factor FOXA1 leading to the prognostic value of estrogen receptor and FOXA1 co-expression in breast cancer. / 28.09.2019 / PubMed / Full text
The correlation of copy number variations with longevity in a genome-wide association study of Han Chinese. / 05.06.2018 / PubMed / Full text
FOXA1 and SOX9 Expression in the Developing Urogenital Sinus of the Tammar Wallaby (Macropus eugenii). / 2015 / PubMed / Full text
Epigenetic mechanisms of peptidergic regulation of gene expression during aging of human cells. / 03.2015 / PubMed / Full text
Association of levels of fasting glucose and insulin with rare variants at the chromosome 11p11.2-MADD locus: Cohorts for Heart and Aging Research in Genomic Epidemiology (CHARGE) Consortium Targeted Sequencing Study. / 06.2014 / PubMed / Full text

FOXN1

Thymic rejuvenation via FOXN1-reprogrammed embryonic fibroblasts (FREFs) to counteract age-related inflammation. / 17.09.2020 / PubMed / Full text
Role of Bone Marrow Maturity, Insulin-Like Growth Factor 1 Receptor, and Forkhead Box Protein N1 in Thymic Involution and Rejuvenation. / 10.2016 / PubMed / Full text
Foxn1 Is Dynamically Regulated in Thymic Epithelial Cells during Embryogenesis and at the Onset of Thymic Involution. / 2016 / PubMed / Full text
A deletion in FOXN1 is associated with a syndrome characterized by congenital hypotrichosis and short life expectancy in Birman cats. / 2015 / PubMed / Full text
Regeneration of the aged thymus by a single transcription factor. / 04.2014 / PubMed / Full text

FOXO6

Novel molecular mechanisms for the adaptogenic effects of herbal extracts on isolated brain cells using systems biology. / 15.11.2018 / PubMed / Full text
Introduction to FOXO Biology. / 2019 / PubMed / Full text
FOXO in Neural Cells and Diseases of the Nervous System. / 2018 / PubMed / Full text
FOXO Transcriptional Factors and Long-Term Living. / 2017 / PubMed / Full text
Long live FOXO: unraveling the role of FOXO proteins in aging and longevity. / 04.2016 / PubMed / Full text

GCLC

Aerobic exercise training partially reverses the impairment of Nrf2 activation in older humans. / 20.11.2020 / PubMed / Full text
Ontogeny and aging of Nrf2 pathway genes in livers of rats. / 15.06.2018 / PubMed / Full text
Proteomic profiling of follicle fluids after superstimulation in one-month-old lambs. / 02.2018 / PubMed / Full text
Increase in Blood Glutathione and Erythrocyte Proteins Related to Glutathione Generation, Reduction and Utilization in African-American Old Women with Diabetes. / 2015 / PubMed / Full text
Contribution of genetic polymorphisms on functional status at very old age: a gene-based analysis of 38 genes (311 SNPs) in the oxidative stress pathway. / 04.2014 / PubMed / Full text

GEM

The Impact of Geriatric Emergency Management Nurses on the Care of Frail Older Patients in the Emergency Department: a Systematic Review. / 09.2020 / PubMed / Full text
Cytosolic and mitochondrial Ca concentrations in primary hepatocytes change with ageing and in consequence of an mtDNA mutation. / 09.2019 / PubMed / Full text
Understanding of diagnosis and medications among non-English-speaking older patients. / 06.2018 / PubMed / Full text
Increased gait variability may not imply impaired stride-to-stride control of walking in healthy older adults: Winner: 2013 Gait and Clinical Movement Analysis Society Best Paper Award. / 06.2017 / PubMed / Full text
The development and evaluation of mini-GEMs - short, focused, online e-learning videos in geriatric medicine. / 04-06.2018 / PubMed / Full text

GGCT

Blockade of γ-Glutamylcyclotransferase Enhances Docetaxel Growth Inhibition of Prostate Cancer Cells. / 09.2019 / PubMed / Full text
Mechanisms of Tumor Growth Inhibition by Depletion of γ-Glutamylcyclotransferase (GGCT): A Novel Molecular Target for Anticancer Therapy. / 14.07.2018 / PubMed / Full text
Depletion of gamma-glutamylcyclotransferase in cancer cells induces autophagy followed by cellular senescence. / 2018 / PubMed / Full text
Prohibitin-2 is a novel regulator of p21 induced by depletion of γ-glutamylcyclotransferase. / 29.01.2018 / PubMed / Full text
Depletion of γ-glutamylcyclotransferase inhibits breast cancer cell growth via cellular senescence induction mediated by CDK inhibitor upregulation. / 22.09.2016 / PubMed / Full text

GPX4

l-carnitine supplementation during in vitro culture regulates oxidative stress in embryos from bovine aged oocytes. / 02.2020 / PubMed / Full text
Dietary Selenium Supplementation Ameliorates Female Reproductive Efficiency in Aging Mice. / 11.12.2019 / PubMed / Full text
Resveratrol improves in vitro maturation of oocytes in aged mice and humans. / 05.2018 / PubMed / Full text
Differential menopause- versus aging-induced changes in oxidative stress and circadian rhythm gene markers. / 06.2017 / PubMed / Full text
Maternal obesity in the rat impairs male offspring aging of the testicular antioxidant defence system. / 09.2017 / PubMed / Full text

HMGB2

Loss of Endogenous HMGB2 Promotes Cardiac Dysfunction and Pressure Overload-Induced Heart Failure in Mice. / 25.01.2019 / PubMed / Full text
HMGB2 Loss upon Senescence Entry Disrupts Genomic Organization and Induces CTCF Clustering across Cell Types. / 17.05.2018 / PubMed / Full text
Correlations between age, functional status, and the senescence-associated proteins HMGB2 and p16 . / 04.2018 / PubMed / Full text
Transcriptional Repression of High-Mobility Group Box 2 by p21 in Radiation-Induced Senescence. / 30.04.2018 / PubMed / Full text
Loss of Endometrial Plasticity in Recurrent Pregnancy Loss. / 02.2016 / PubMed / Full text

IGF2

Paternal Insulin-like Growth Factor 2 (Igf2) Regulates Stem Cell Activity During Adulthood. / 02.2017 / PubMed / Full text
Genetic variation and exercise-induced muscle damage: implications for athletic performance, injury and ageing. / 09.2016 / PubMed / Full text
Autocrine Action of IGF2 Regulates Adult β-Cell Mass and Function. / 12.2015 / PubMed / Full text
Enhanced memory consolidation in mice lacking the circadian modulators Sharp1 and -2 caused by elevated Igf2 signaling in the cortex. / 07.07.2015 / PubMed / Full text
miR-30e targets IGF2-regulated osteogenesis in bone marrow-derived mesenchymal stem cells, aortic smooth muscle cells, and ApoE-/- mice. / 01.04.2015 / PubMed / Full text

IK

Pial Collateral Reactivity During Hypertension and Aging: Understanding the Function of Collaterals for Stroke Therapy. / 06.2016 / PubMed / Full text
Endothelium-dependent hyperpolarization: age, gender and blood pressure, do they matter? / 01.2017 / PubMed / Full text
17β-estradiol potentiates endothelium-dependent nitric oxide- and hyperpolarization-mediated relaxations in blood vessels of male but not female apolipoprotein-E deficient mice. / 08.2015 / PubMed / Full text
Altered neutrophil functions in elderly patients during a 6-month follow-up period after a hip fracture. / 05.2015 / PubMed / Full text
Microglial K( ) channel expression in young adult and aged mice. / 04.2015 / PubMed / Full text

IL2

Impact of Aging on the Phenotype of Invariant Natural Killer T Cells in Mouse Thymus. / 2020 / PubMed / Full text
Redox, immune and genetic biomarker system for personalized treatments in colorectal cancer. / 15.02.2019 / PubMed / Full text
Low IL-2 Expressing T Cells in Thalassemia Major Patients: Is It Immune Aging. / 10.2018 / PubMed / Full text
Epigenetic repression of interleukin 2 expression in senescent CD4 T cells during chronic HIV type 1 infection. / 01.01.2015 / PubMed / Full text
Cytomegalovirus infection modulates the phenotype and functional profile of the T-cell immune response to mycobacterial antigens in older life. / 06.2014 / PubMed / Full text

IRS2

Effects of Heshouwuyin on gene expression of the insulin/IGF signalling pathway in rat testis and spermatogenic cells. / 12.2020 / PubMed / Full text
Involvement of insulin receptor substrates in cognitive impairment and Alzheimer's disease. / 08.2019 / PubMed / Full text
The senescent status of endothelial cells affects proliferation, inflammatory profile and SOX2 expression in bone marrow-derived mesenchymal stem cells. / 06.2019 / PubMed / Full text
Therapeutic and preventive effects of exercise on cardiometabolic parameters in aging and obese rats. / 02.2019 / PubMed / Full text
Analysis of MTNR1B gene polymorphisms in relationship with IRS2 gene variants, epicardial fat thickness, glucose homeostasis and cognitive performance in the elderly. / 2017 / PubMed / Full text

JAK1

Irradiation-induced senescence of bone marrow mesenchymal stem cells aggravates osteogenic differentiation dysfunction via paracrine signaling. / 01.05.2020 / PubMed / Full text
The Upregulation of Toll-Like Receptor 3 via Autocrine IFN-β Signaling Drives the Senescence of Human Umbilical Cord Blood-Derived Mesenchymal Stem Cells Through JAK1. / 2019 / PubMed / Full text
Influence of age and renal impairment on the steady state pharmacokinetics of filgotinib, a selective JAK1 inhibitor. / 12.2018 / PubMed / Full text
Immunologic effects of chronic administration of tofacitinib, a Janus kinase inhibitor, in cynomolgus monkeys and rats - Comparison of juvenile and adult responses. / 04.2018 / PubMed / Full text
Interferon-γ induces senescence in normal human melanocytes. / 2014 / PubMed / Full text

LRP1

Drug Targeting of Plasminogen Activator Inhibitor-1 Inhibits Metabolic Dysfunction and Atherosclerosis in a Murine Model of Metabolic Syndrome. / 06.2020 / PubMed / Full text
LXR activation protects hippocampal microvasculature in very old triple transgenic mouse model of Alzheimer's disease. / 16.05.2016 / PubMed / Full text
Rescuing effects of RXR agonist bexarotene on aging-related synapse loss depend on neuronal LRP1. / 03.2016 / PubMed / Full text
Age-Related Decline in Brain and Hepatic Clearance of Amyloid-Beta is Rectified by the Cholinesterase Inhibitors Donepezil and Rivastigmine in Rats. / 20.05.2015 / PubMed / Full text
Reduced neuronal signaling in the ageing apolipoprotein-E4 targeted replacement female mice. / 10.10.2014 / PubMed / Full text

MAL

Daylight photodynamic therapy versus cryosurgery for the treatment and prophylaxis of actinic keratoses of the face - protocol of a multicenter, prospective, randomized, controlled, two-armed study. / 25.10.2017 / PubMed / Full text
Infant Nutritional Status, Feeding Practices, Enteropathogen Exposure, Socioeconomic Status, and Illness Are Associated with Gut Barrier Function As Assessed by the Lactulose Mannitol Test in the MAL-ED Birth Cohort. / 07.2017 / PubMed / Full text
Solutions to Peto's paradox revealed by mathematical modelling and cross-species cancer gene analysis. / 19.07.2015 / PubMed / Full text
Age-related expression analysis of mouse liver nuclear protein binding to 3'-untranslated region of Period2 gene. / 07.2015 / PubMed / Full text
Evaluation of dermal extracellular matrix and epidermal-dermal junction modifications using matrix-assisted laser desorption/ionization mass spectrometric imaging, in vivo reflectance confocal microscopy, echography, and histology: effect of age and peptide applications. / 06.2015 / PubMed / Full text

MLN

Age-Dependent Decrease in the Induction of Regulatory T Cells Is Associated With Decreased Expression of RALDH2 in Mesenteric Lymph Node Dendritic Cells. / 2020 / PubMed / Full text
Variability of Spleen and Mesenteric Lymph Node in Control Cynomolgus Monkeys ( Macaca fascicularis) from Nonclinical Safety Studies: A Retrospective Assessment. / 01.2019 / PubMed / Full text
Microanatomical dissection of human intestinal T-cell immunity reveals site-specific changes in gut-associated lymphoid tissues over life. / 03.2019 / PubMed / Full text
Immunological Basis for Rapid Progression of Diabetes in Older NOD Mouse Recipients Post BM-HSC Transplantation. / 2015 / PubMed / Full text
Targeting protein neddylation with an NEDD8-activating enzyme inhibitor MLN4924 induced apoptosis or senescence in human lymphoma cells. / 2015 / PubMed / Full text

MME

Geriatric Opioid Harm Reduction: Interprofessional Student Learning Outcomes. / 01-12.2020 / PubMed / Full text
Effectiveness of local anesthetic injection in geriatric patients following operative management of proximal and diaphyseal femur fracture. / 11.2019 / PubMed / Full text
Membrane metallo-endopeptidase mediates cellular senescence induced by oncogenic PIK3CA accompanied with pro-tumorigenic secretome. / 01.08.2019 / PubMed / Full text
Medial meniscus extrusion increases with age and BMI and is depending on different loading conditions. / 08.2018 / PubMed / Full text
Rare Variants in MME, Encoding Metalloprotease Neprilysin, Are Linked to Late-Onset Autosomal-Dominant Axonal Polyneuropathies. / 01.09.2016 / PubMed / Full text

MVD

Prostate cancer aggressiveness and age: Impact of p53, BCL-2 and microvessel density. / 12.2018 / PubMed / Full text
Assessing Microvascular Function in Humans from a Chronic Disease Perspective. / 12.2017 / PubMed / Full text
Changes in pro-inflammatory markers and leucine concentrations in response to Nordic Walking training combined with vitamin D supplementation in elderly women. / 08.2017 / PubMed / Full text
Diffusion-weighted multiparametric MRI for monitoring longitudinal changes of parameters in rabbit VX2 liver tumors. / 09.2016 / PubMed / Full text
[Expression of vascular endothelial growth factor and microvessel density in different brain regions in aged rats]. / 07.2014 / PubMed / Full text

NEDD8

Targeting Protein Neddylation for Cancer Therapy. / 2020 / PubMed / Full text
Effective targeting of the ubiquitin-like modifier NEDD8 for lung adenocarcinoma treatment. / 08.2020 / PubMed / Full text
Pevonedistat targeted therapy inhibits canine melanoma cell growth through induction of DNA re-replication and senescence. / 09.2020 / PubMed / Full text
Protein neddylation and its alterations in human cancers for targeted therapy. / 04.2018 / PubMed / Full text
Targeting protein neddylation with an NEDD8-activating enzyme inhibitor MLN4924 induced apoptosis or senescence in human lymphoma cells. / 2015 / PubMed / Full text

NFE2L2

The double-edged sword of MTOR in autophagy deficiency induced-liver injury and tumorigenesis. / 09.2019 / PubMed / Full text
The Association of a Single-Nucleotide Polymorphism in the Nuclear Factor (Erythroid-Derived 2)-Like 2 Gene With Adverse Drug Reactions, Multimorbidity, and Frailty in Older People. / 22.05.2020 / PubMed / Full text
Immunohistochemical localization of Nrf2 in the human cochlea. / 01.12.2018 / PubMed / Full text
Lifespan extension by peroxidase and dual oxidase-mediated ROS signaling through pyrroloquinoline quinone in [i]C. elegans[/i]. / 01.08.2017 / PubMed / Full text
Defective autophagy in vascular smooth muscle cells accelerates senescence and promotes neointima formation and atherogenesis. / 02.11.2015 / PubMed / Full text

NOS3

Application of Oxidative Stress to a Tissue-Engineered Vascular Aging Model Induces Endothelial Cell Senescence and Activation. / 22.05.2020 / PubMed / Full text
Hypertension and longevity: role of genetic polymorphisms in renin-angiotensin-aldosterone system and endothelial nitric oxide synthase. / 05.2019 / PubMed / Full text
NOS3 Inhibition Confers Post-Ischemic Protection to Young and Aging White Matter Integrity by Conserving Mitochondrial Dynamics and Miro-2 Levels. / 11.07.2018 / PubMed / Full text
Vascular senescence and ageing: a role for the MEOX proteins in promoting endothelial dysfunction. / 10.2017 / PubMed / Full text
Fetal programming of blood pressure in a transgenic mouse model of altered intrauterine environment. / 01.12.2016 / PubMed / Full text

NPR1

The NPR1-WRKY46-WRKY6 signaling cascade mediates probenazole/salicylic acid-elicited leaf senescence in Arabidopsis thaliana. / 03.12.2020 / PubMed / Full text
Loss of proton/calcium exchange 1 results in the activation of plant defense and accelerated senescence in Arabidopsis. / 07.2020 / PubMed / Full text
Some things get better with age: differences in salicylic acid accumulation and defense signaling in young and mature Arabidopsis. / 2014 / PubMed / Full text
Mitogen-activated protein kinase 6 regulates NPR1 gene expression and activation during leaf senescence induced by salicylic acid. / 12.2014 / PubMed / Full text
Autophagy deficiency leads to accumulation of ubiquitinated proteins, ER stress, and cell death in Arabidopsis. / 09.2014 / PubMed / Full text

NRK

[Molecular mechanisms of mycelium of Cordyceps sinensis ameliorating renal tubular epithelial cells aging induced by D-galactose via inhibiting autophagy-related AMPK/ULK1 signaling activation]. / 03.2019 / PubMed / Full text
Hyperoside attenuates renal aging and injury induced by D-galactose via inhibiting AMPK-ULK1 signaling-mediated autophagy. / 24.12.2018 / PubMed / Full text
Fascin2 regulates cisplatin-induced apoptosis in NRK-52E cells. / 15.01.2017 / PubMed / Full text
2,3,5,4'-Tetrahydroxystilbene-2-O-[i]β[/i]-D-glucoside Promotes Expression of the Longevity Gene Klotho. / 2016 / PubMed / Full text
A role for the age-dependent loss of α(E)-catenin in regulation of N-cadherin expression and cell migration. / 01.06.2014 / PubMed / Full text

PIN1

Brain somatic mutations observed in Alzheimer's disease associated with aging and dysregulation of tau phosphorylation. / 12.07.2019 / PubMed / Full text
Class XI Myosins Contribute to Auxin Response and Senescence-Induced Cell Death in [i]Arabidopsis[/i]. / 2018 / PubMed / Full text
Effects of Melatonin and Its Underlying Mechanism on Ethanol-Stimulated Senescence and Osteoclastic Differentiation in Human Periodontal Ligament Cells and Cementoblasts. / 12.06.2018 / PubMed / Full text
Integrative Analysis of Hippocampus Gene Expression Profiles Identifies Network Alterations in Aging and Alzheimer's Disease. / 2018 / PubMed / Full text
Dynamic Phosphorylation of the Myocyte Enhancer Factor 2Cα1 Splice Variant Promotes Skeletal Muscle Regeneration and Hypertrophy. / 03.2017 / PubMed / Full text

POLD1

Epigenetic signatures of Werner syndrome occur early in life and are distinct from normal epigenetic aging processes. / 10.2019 / PubMed / Full text
POLD1 deficiency is involved in cognitive function impairment in AD patients and SAMP8 mice. / 06.2019 / PubMed / Full text
E2F1 mediates the downregulation of POLD1 in replicative senescence. / 07.2019 / PubMed / Full text
Mandibuloacral dysplasia: A premature ageing disease with aspects of physiological ageing. / 03.2018 / PubMed / Full text
POLD1: Central mediator of DNA replication and repair, and implication in cancer and other pathologies. / 15.09.2016 / PubMed / Full text

PRMT1

Reactive oxygen species extend insect life span using components of the insulin-signaling pathway. / 12.09.2017 / PubMed / Full text
Regenerating muscle with arginine methylation. / 27.05.2017 / PubMed / Full text
Simultaneous ablation of prmt-1 and prmt-5 abolishes asymmetric and symmetric arginine dimethylations in Caenorhabditis elegans. / 01.06.2017 / PubMed / Full text
Caveolin1/protein arginine methyltransferase1/sirtuin1 axis as a potential target against endothelial dysfunction. / 05.2017 / PubMed / Full text
Epigallocatechin-3-gallate ameliorates erectile function in aged rats via regulation of PRMT1/DDAH/ADMA/NOS metabolism pathway. / 05-06.2017 / PubMed / Full text

PROC

Does midlife aging impact women's sleep duration, continuity, and timing?: A longitudinal analysis from the Study of Women's Health Across the Nation. / 15.04.2020 / PubMed / Full text
Effects of feeding frequency of an elevated plane of milk replacer and calf age on behavior, and glucose and insulin kinetics in male Holstein calves. / 07.2019 / PubMed / Full text
Age-related effects on markers of inflammation and cartilage metabolism in response to an intra-articular lipopolysaccharide challenge in horses. / 02.2017 / PubMed / Full text
Normative data for rotational chair stratified by age. / 02.2016 / PubMed / Full text
Day-to-Day Impact of Vaginal Aging questionnaire: a multidimensional measure of the impact of vaginal symptoms on functioning and well-being in postmenopausal women. / 02.2015 / PubMed / Full text

PTS

Posttraumatic stress symptom persistence across 24 years: association with brain structures. / 08.2020 / PubMed / Full text
Association of prenatal and childhood environment smoking exposure with puberty timing: a systematic review and meta-analysis. / 18.07.2018 / PubMed / Full text
Post-traumatic stress syndrome in a large sample of older adults: determinants and quality of life. / 2016 / PubMed / Full text
Continuous exposure to life threats among different age groups in different types of communities. / 05.2015 / PubMed / Full text
Post-traumatic stress symptoms and adult attachment: a 24-year longitudinal study. / 12.2014 / PubMed / Full text

PTX3

Aerobic Training Down-Regulates Pentraxin 3 and Pentraxin 3/Toll-Like Receptor 4 Ratio, Irrespective of Oxidative Stress Response, in Elderly Subjects. / 27.01.2020 / PubMed / Full text
Sex Differences in the Association Between Pentraxin 3 and Cognitive Decline: The Cardiovascular Health Study. / 13.07.2020 / PubMed / Full text
Inflammatory Long Pentraxin 3 is Associated with Leukocyte Telomere Length in Night-Shift Workers. / 2017 / PubMed / Full text
Age-dependent cellular reactions of the human immune system of humanized NOD scid gamma mice on LPS stimulus. / 04.2017 / PubMed / Full text
Elevated pentraxin 3 level at the early stage of exercise training is associated with reduction of arterial stiffness in middle-aged and older adults. / 09.2016 / PubMed / Full text

PYY

Peptide YY (PYY) Is Expressed in Human Skeletal Muscle Tissue and Expanding Human Muscle Progenitor Cells. / 2019 / PubMed / Full text
Peptide YY induces characteristic meal patterns of aged mice. / 11.2017 / PubMed / Full text
Effects of randomized whey-protein loads on energy intake, appetite, gastric emptying, and plasma gut-hormone concentrations in older men and women. / 09.2017 / PubMed / Full text
Glucagon-like peptide-1 (GLP-1) increases in plasma and colon tissue prior to estrus and circulating levels change with increasing age in reproductively competent Wistar rats. / 04.2017 / PubMed / Full text
Increased peptide YY blood concentrations, not decreased acyl-ghrelin, are associated with reduced hunger and food intake in healthy older women: Preliminary evidence. / 01.10.2016 / PubMed / Full text

RACK1

Invariable stoichiometry of ribosomal proteins in mouse brain tissues with aging. / 05.11.2019 / PubMed / Full text
Role of Hormones in the Regulation of RACK1 Expression as a Signaling Checkpoint in Immunosenescence. / 06.07.2017 / PubMed / Full text
Transcriptional regulation of RACK1 and modulation of its expression: Role of steroid hormones and significance in health and aging. / 07.2017 / PubMed / Full text
Role of androgens in dhea-induced rack1 expression and cytokine modulation in monocytes. / 2016 / PubMed / Full text
Immunostimulatory effects of RACK1 pseudosubstrate in human leukocytes obtained from young and old donors. / 30.03.2015 / PubMed / Full text

RB1

G protein-coupled receptor kinase 4-induced cellular senescence and its senescence-associated gene expression profiling. / 15.11.2017 / PubMed / Full text
Mesenchymal stromal cells having inactivated RB1 survive following low irradiation and accumulate damaged DNA: Hints for side effects following radiotherapy. / 02.2017 / PubMed / Full text
Suppression of RAD21 Induces Senescence of MDA-MB-231 Human Breast Cancer Cells Through RB1 Pathway Activation Via c-Myc Downregulation. / 06.2016 / PubMed / Full text
Exercise-associated DNA methylation change in skeletal muscle and the importance of imprinted genes: a bioinformatics meta-analysis. / 12.2015 / PubMed / Full text
RB1-mediated cell-autonomous and host-dependent oncosuppressor mechanisms in radiation-induced osteosarcoma. / 01.01.2014 / PubMed / Full text

REN

The Hispanic Paradox: Race/Ethnicity and Nativity, Immigrant Enclave Residence and Cognitive Impairment Among Older US Adults. / 05.2017 / PubMed / Full text
Analysis of Clinical Features and Outcomes of Skull Base Chordoma in Different Age-Groups. / 08.2016 / PubMed / Full text
ASSOCIATION OF PREVASCULAR VITREOUS FISSURES AND CISTERNS WITH VITREOUS DEGENERATION AS ASSESSED BY SWEPT SOURCE OPTICAL COHERENCE TOMOGRAPHY. / 09.2015 / PubMed / Full text
Effects of advanced age and renal dysfunction on the single- and repeated-dose pharmacokinetics of modified-release flupirtine. / 03.2015 / PubMed / Full text
Mapping nutrient resorption efficiencies of subarctic cryptogams and seed plants onto the Tree of Life. / 06.2014 / PubMed / Full text

RHO

Conditional reprogramming: next generation cell culture. / 08.2020 / PubMed / Full text
SARS-CoV-2 receptor ACE2 and TMPRSS2 are primarily expressed in bronchial transient secretory cells. / 18.05.2020 / PubMed / Full text
Redox Signaling of NADPH Oxidases Regulates Oxidative Stress Responses, Immunity and Aging. / 28.09.2018 / PubMed / Full text
NADPH oxidase-mediated redox signaling promotes oxidative stress resistance and longevity through [i]memo-1[/i] in [i]C. elegans[/i]. / 13.01.2017 / PubMed / Full text
Guanine nucleotide exchange factor OSG-1 confers functional aging via dysregulated Rho signaling in Caenorhabditis elegans neurons. / 02.2015 / PubMed / Full text

RICTOR

Endothelial senescence-associated secretory phenotype (SASP) is regulated by Makorin-1 ubiquitin E3 ligase. / 11.2019 / PubMed / Full text
The underlying mechanism of proinflammatory NF-κB activation by the mTORC2/Akt/IKKα pathway during skin aging. / 16.08.2016 / PubMed / Full text
MicroRNA-188 regulates age-related switch between osteoblast and adipocyte differentiation. / 04.2015 / PubMed / Full text
Depletion of Rictor, an essential protein component of mTORC2, decreases male lifespan. / 10.2014 / PubMed / Full text
Genetic analysis of TOR complex gene variation with human longevity: a nested case-control study of American men of Japanese ancestry. / 02.2015 / PubMed / Full text

RIPK3

Metformin mediates cardioprotection against aging-induced ischemic necroptosis. / 02.2020 / PubMed / Full text
A small molecule Nec-1 directly induces amyloid clearance in the brains of aged APP/PS1 mice. / 12.03.2019 / PubMed / Full text
RIP kinases as modulators of inflammation and immunity. / 09.2018 / PubMed / Full text
Necroptosis increases with age and is reduced by dietary restriction. / 08.2018 / PubMed / Full text
RIPK1-RIPK3-MLKL-dependent necrosis promotes the aging of mouse male reproductive system. / 15.08.2017 / PubMed / Full text

S100A8

S100A8, which increases with age, induces cellular senescence-like changes in bovine oviduct epithelial cells. / 09.2019 / PubMed / Full text
Fetal articular cartilage regeneration versus adult fibrocartilaginous repair: secretome proteomics unravels molecular mechanisms in an ovine model. / 06.07.2018 / PubMed / Full text
Lung cellular senescence is independent of aging in a mouse model of COPD/emphysema. / 13.06.2018 / PubMed / Full text
Age-dependent changes in inflammation and extracellular matrix in bovine oviduct epithelial cells during the post-ovulatory phase. / 09.2016 / PubMed / Full text
A transcriptional roadmap to the senescence and differentiation of human oral keratinocytes. / 01.2015 / PubMed / Full text

SCT

Short-Term Training and Detraining Effects of Supervised vs. Unsupervised Resistance Exercise in Aging Adults. / 10.2019 / PubMed / Full text
High-intensity interval training improves acute plasma volume responses to exercise that is age dependent. / 02.2018 / PubMed / Full text
Communication technology adoption among older adult veterans: the interplay of social and cognitive factors. / 12.2018 / PubMed / Full text
Repeatability of Choroidal Thickness Measurements on Enhanced Depth Imaging Optical Coherence Tomography Using Different Posterior Boundaries. / 09.2016 / PubMed / Full text
HIV cure strategies: how good must they be to improve on current antiretroviral therapy? / 2014 / PubMed / Full text

SET

Chromatin Modifiers SET-25 and SET-32 Are Required for Establishment but Not Long-Term Maintenance of Transgenerational Epigenetic Inheritance. / 20.11.2018 / PubMed / Full text
SET-9 and SET-26 are H3K4me3 readers and play critical roles in germline development and longevity. / 01.05.2018 / PubMed / Full text
Muscle-Specific Histone H3K36 Dimethyltransferase SET-18 Shortens Lifespan of Caenorhabditis elegans by Repressing daf-16a Expression. / 06.03.2018 / PubMed / Full text
Assessing efficacy of day 3 embryo time-lapse algorithms retrospectively: impacts of dataset type and confounding factors. / 09.2019 / PubMed / Full text
CONSTANCES: a general prospective population-based cohort for occupational and environmental epidemiology: cohort profile. / 01.2017 / PubMed / Full text

SMAD4

A clinical trial of somatic and germline analyses for healthy longevity in a postoperative cancer patient. / 09.2019 / PubMed / Full text
E47 Governs the MYC-CDKN1B/p27 -RB Network to Growth Arrest PDA Cells Independent of CDKN2A/p16 and Wild-Type p53. / 2018 / PubMed / Full text
iTRAQ-based proteomic profiling of granulosa cells from lamb and ewe after superstimulation. / 01.10.2017 / PubMed / Full text
miR-431 promotes differentiation and regeneration of old skeletal muscle by targeting Smad4. / 01.08.2015 / PubMed / Full text
Loss of smad4 in Sertoli and Leydig cells leads to testicular dysgenesis and hemorrhagic tumor formation in mice. / 03.2014 / PubMed / Full text

SMS

Does a Live Performance Impact Synchronization to Musical Rhythm in Cognitively Impaired Elderly? / 2020 / PubMed / Full text
Testing the effectiveness of physical activity advice delivered via text messaging vs. human phone advisors in a Latino population: The On The Move randomized controlled trial design and methods. / 08.2020 / PubMed / Full text
Mobile Health Interventions for Physical Activity, Sedentary Behavior, and Sleep in Adults Aged 50 Years and Older: A Systematic Literature Review. / 01.08.2019 / PubMed / Full text
Senescence-messaging secretome factors trigger premature senescence in human endometrium-derived stem cells. / 19.02.2018 / PubMed / Full text
PAI-1-regulated extracellular proteolysis governs senescence and survival in Klotho mice. / 13.05.2014 / PubMed / Full text

SNAP25

The Biological Foundations of Sarcopenia: Established and Promising Markers. / 2019 / PubMed / Full text
Frontotemporal dysregulation of the SNARE protein interactome is associated with faster cognitive decline in old age. / 06.2018 / PubMed / Full text
NUPR1 maintains autolysosomal efflux by activating SNAP25 transcription in cancer cells. / 2018 / PubMed / Full text
Global hypoxia induced impairment in learning and spatial memory is associated with precocious hippocampal aging. / 09.2016 / PubMed / Full text
NOS1 and SNAP25 polymorphisms are associated with Attention-Deficit/Hyperactivity Disorder symptoms in adults but not in children. / 04.2016 / PubMed / Full text

SOCS1

Individual and combined effects of salinity and lipopolysaccharides on the immune response of juvenile Takifugu fasciatus. / 06.2019 / PubMed / Full text
SOCS1 regulates senescence and ferroptosis by modulating the expression of p53 target genes. / 28.10.2017 / PubMed / Full text
Daily Socs1 rhythms alter with aging differentially in peripheral clocks in male Wistar rats: therapeutic effects of melatonin. / 06.2017 / PubMed / Full text
Differential response to intrahippocampal interleukin-4/interleukin-13 in aged and exercise mice. / 20.02.2017 / PubMed / Full text
Aging diminishes the resistance of AO rats to EAE: putative role of enhanced generation of GM-CSF Expressing CD4 T cells in aged rats. / 2015 / PubMed / Full text

TAT

Mitochondrial Quality Control in Aging and Heart Failure: Influence of Ketone Bodies and Mitofusin-Stabilizing Peptides. / 2019 / PubMed / Full text
Effects of HIV-1 gp120 and TAT-derived microvesicles on endothelial cell function. / 01.05.2019 / PubMed / Full text
Sumoylation-deficient Prdx6 gains protective function by amplifying enzymatic activity and stability and escapes oxidative stress-induced aberrant Sumoylation. / 05.01.2017 / PubMed / Full text
Characteristics, tissue-specific expression, and hormonal regulation of expression of tyrosine aminotransferase in the avian female reproductive tract. / 10.2016 / PubMed / Full text
Nanog induces suppression of senescence through downregulation of p27KIP1 expression. / 01.03.2016 / PubMed / Full text

TCF7L2

A myelin-related transcriptomic profile is shared by Pitt-Hopkins syndrome models and human autism spectrum disorder. / 03.2020 / PubMed / Full text
Lifelong physical activity is associated with promoter hypomethylation of genes involved in metabolism, myogenesis, contractile properties and oxidative stress resistance in aged human skeletal muscle. / 01.03.2019 / PubMed / Full text
TCF7L1 promotes skin tumorigenesis independently of β-catenin through induction of LCN2. / 03.05.2017 / PubMed / Full text
[Frequency of some diseases and conditions in geriatric patients with coronary heart disease and various genotypes of transcription factor 7-like 2 protein]. / 2014 / PubMed
Aging and cardiovascular diseases: the role of gene-diet interactions. / 11.2014 / PubMed / Full text

TLR1

Effects of aging and lifelong aerobic exercise on expression of innate immune components in human skeletal muscle. / 01.12.2020 / PubMed / Full text
Association of TLR gene variants in a Czech Red Pied cattle population with reproductive traits. / 02.2020 / PubMed / Full text
Decreased NLRP3 inflammasome expression in aged lung may contribute to increased susceptibility to secondary Streptococcus pneumoniae infection. / 05.2018 / PubMed / Full text
Changes in the expression of the Toll-like receptor system in the aging rat kidneys. / 2014 / PubMed / Full text
Reduced bioenergetics and toll-like receptor 1 function in human polymorphonuclear leukocytes in aging. / 02.2014 / PubMed / Full text

TRPA1

Important regulatory function of transient receptor potential ankyrin 1 receptors in age-related learning and memory alterations of mice. / 10.2019 / PubMed / Full text
Aging of mouse intervertebral disc and association with back pain. / 06.2019 / PubMed / Full text
Congeneric variability in lifespan extension and onset of senescence suggest active regulation of aging in response to low temperature. / 12.2018 / PubMed / Full text
A comparative study on the therapeutic effect of TRPV1, TRPA1, and TRPM8 agonists on swallowing dysfunction associated with aging and neurological diseases. / 02.2018 / PubMed / Full text
A Caenorhabditis elegans Model Elucidates a Conserved Role for TRPA1-Nrf Signaling in Reactive α-Dicarbonyl Detoxification. / 21.11.2016 / PubMed / Full text

TRPM8

Morphological and functional changes in TRPM8-expressing corneal cold thermoreceptor neurons during aging and their impact on tearing in mice. / 01.08.2018 / PubMed / Full text
A comparative study on the therapeutic effect of TRPV1, TRPA1, and TRPM8 agonists on swallowing dysfunction associated with aging and neurological diseases. / 02.2018 / PubMed / Full text
Roles of TRPM8 Ion Channels in Cancer: Proliferation, Survival, and Invasion. / 23.10.2015 / PubMed / Full text
Function and postnatal changes of dural afferent fibers expressing TRPM8 channels. / 26.06.2015 / PubMed / Full text
Induction of oxidative stress causes functional alterations in mouse urothelium via a TRPM8-mediated mechanism: implications for aging. / 06.2014 / PubMed / Full text

UCP3

Integrated study on comparative transcriptome and skeletal muscle function in aged rats. / 01.2018 / PubMed / Full text
Pleiotropic effects of UCP2-UCP3 variability on leucocyte telomere length and glucose homeostasis. / 06.2017 / PubMed / Full text
Single nucleotide polymorphisms linked to mitochondrial uncoupling protein genes UCP2 and UCP3 affect mitochondrial metabolism and healthy aging in female nonagenarians. / 08.2016 / PubMed / Full text
[Genotype and allele frequencies of UCP and PPAR gene families in residents of besieged Leningrad and in the control group]. / 2014 / PubMed
Contribution of genetic polymorphisms on functional status at very old age: a gene-based analysis of 38 genes (311 SNPs) in the oxidative stress pathway. / 04.2014 / PubMed / Full text

VCP

The role of air pollution and lung function in cognitive impairment. / 02.2018 / PubMed / Full text
Better parameters of ventilation-CO₂output relationship predict death in CHF patients. / 11.2015 / PubMed
Valosin-containing protein is a key mediator between autophagic cell death and apoptosis in adult hippocampal neural stem cells following insulin withdrawal. / 22.03.2016 / PubMed / Full text
Frontotemporal dementia: insights into the biological underpinnings of disease through gene co-expression network analysis. / 24.02.2016 / PubMed / Full text
Characterization of C-terminal adaptors, UFD-2 and UFD-3, of CDC-48 on the polyglutamine aggregation in C. elegans. / 27.03.2015 / PubMed / Full text

VDAC1

Low abundance of NDUFV2 and NDUFS4 subunits of the hydrophilic complex I domain and VDAC1 predicts mammalian longevity. / 07.2020 / PubMed / Full text
Changes in the expression of oxidative phosphorylation complexes in the aging intestinal mucosa. / 01.07.2020 / PubMed / Full text
Cytosolic and mitochondrial Ca concentrations in primary hepatocytes change with ageing and in consequence of an mtDNA mutation. / 09.2019 / PubMed / Full text
The Immp2l mutation causes age-dependent degeneration of cerebellar granule neurons prevented by antioxidant treatment. / 02.2016 / PubMed / Full text
The effect of aging on mitochondrial and cytosolic hepatic intrinsic death pathway and apoptosis associated proteins in Fischer 344 rats. / 07.2015 / PubMed / Full text

WAS

Psychological stress exposure to aged mice causes abnormal feeding patterns with changes in the bout number. / 09.11.2017 / PubMed / Full text
Measuring Work Ability with Its Antecedents: Evaluation of the Work Ability Survey. / 06.2018 / PubMed / Full text
CONSTANCES: a general prospective population-based cohort for occupational and environmental epidemiology: cohort profile. / 01.2017 / PubMed / Full text
Age-Dependent Defects of Regulatory B Cells in Wiskott-Aldrich Syndrome Gene Knockout Mice. / 2015 / PubMed / Full text
Genome-wide association studies of late-onset cardiovascular disease. / 06.2015 / PubMed / Full text

XRCC1

[Protective effect of Wuzi Yanzong recipe on testicular DNA oxidative damage in natural ageing rats]. / 07.2018 / PubMed / Full text
The replicative senescent mesenchymal stem / stromal cells defect in DNA damage response and anti-oxidative capacity. / 2018 / PubMed / Full text
XRCC1 and XPD genetic polymorphisms and susceptibility to age-related cataract: a meta-analysis. / 2015 / PubMed / Full text
Polymorphisms of DNA repair genes XPD (Lys751Gln) and XRCC1 (Arg399Gln), and the risk of age-related cataract: a meta-analysis. / 07.2015 / PubMed / Full text
Association between DNA repair genes (XPD and XRCC1) polymorphisms and susceptibility to age-related cataract (ARC): a meta-analysis. / 08.2014 / PubMed / Full text

ACAD10

Genome-wide association study and annotating candidate gene networks affecting age at first calving in Nellore cattle. / 12.2017 / PubMed / Full text
Metformin: a metabolic modulator. / 07.02.2017 / PubMed / Full text
An Ancient, Unified Mechanism for Metformin Growth Inhibition in C. elegans and Cancer. / 15.12.2016 / PubMed / Full text
Metformin: Restraining Nucleocytoplasmic Shuttling to Fight Cancer and Aging. / 15.12.2016 / PubMed / Full text

ACAT1

An Adult Drosophila Glioma Model for Studying Pathometabolic Pathways of Gliomagenesis. / 06.2019 / PubMed / Full text
Serum starvation of ARPE-19 changes the cellular distribution of cholesterol and Fibulin3 in patterns reminiscent of age-related macular degeneration. / 15.12.2017 / PubMed / Full text
Intramyocellular lipid content and lipogenic gene expression responses following a single bout of resistance type exercise differ between young and older men. / 07.2017 / PubMed / Full text
Prenatal betaine exposure alleviates corticosterone-induced inhibition of CYP27A1 expression in the liver of juvenile chickens associated with its promoter DNA methylation. / 15.05.2017 / PubMed / Full text

ACLY

In S. cerevisiae hydroxycitric acid antagonizes chronological aging and apoptosis regardless of citrate lyase. / 10.2020 / PubMed / Full text
Dietary methionine increased the lipid accumulation in juvenile tiger puffer Takifugu rubripes. / 04.2019 / PubMed / Full text
Spermidine reduces cancer-related mortality in humans. / 02.2019 / PubMed / Full text
ATP-citrate lyase regulates cellular senescence via an AMPK- and p53-dependent pathway. / 01.2015 / PubMed / Full text

ACOX1

Dietary methionine increased the lipid accumulation in juvenile tiger puffer Takifugu rubripes. / 04.2019 / PubMed / Full text
Peroxisomal Acyl-CoA Oxidase Type 1: Anti-Inflammatory and Anti-Aging Properties with a Special Emphasis on Studies with LPS and Argan Oil as a Model Transposable to Aging. / 2018 / PubMed / Full text
Novel PPARα agonist MHY553 alleviates hepatic steatosis by increasing fatty acid oxidation and decreasing inflammation during aging. / 11.07.2017 / PubMed / Full text
Extended Multiplexing of Tandem Mass Tags (TMT) Labeling Reveals Age and High Fat Diet Specific Proteome Changes in Mouse Epididymal Adipose Tissue. / 05.2017 / PubMed / Full text

ADAM17

ACE2/ADAM17/TMPRSS2 Interplay May Be the Main Risk Factor for COVID-19. / 2020 / PubMed / Full text
DNA methylation analysis on purified neurons and glia dissects age and Alzheimer's disease-specific changes in the human cortex. / 25.07.2018 / PubMed / Full text
Role of Adipose Tissue Endothelial ADAM17 in Age-Related Coronary Microvascular Dysfunction. / 06.2017 / PubMed / Full text
Selective Inhibition of ADAM17 Efficiently Mediates Glycoprotein Ibα Retention During Ex Vivo Generation of Human Induced Pluripotent Stem Cell-Derived Platelets. / 03.2017 / PubMed / Full text

ADAMTS9

Proteomic profiling of follicle fluids after superstimulation in one-month-old lambs. / 02.2018 / PubMed / Full text
The ADAMTS9 gene is associated with cognitive aging in the elderly in a Taiwanese population. / 2017 / PubMed / Full text
Adaptive sequence convergence of the tumor suppressor ADAMTS9 between small-bodied mammals displaying exceptional longevity. / 26.02.2017 / PubMed / Full text
Loss of C. elegans GON-1, an ADAMTS9 Homolog, Decreases Secretion Resulting in Altered Lifespan and Dauer Formation. / 2015 / PubMed / Full text

AFP

Effect of Alpha-Fetoprotein on Lifespan of Old Mice. / 12.2016 / PubMed / Full text
Correlation between vitamin D levels and apoptosis in geriatric patients infected with hepatitis C virus genotype 4. / 2016 / PubMed / Full text
A new paradigm about HERV-K102 particle production and blocked release to explain cortisol mediated immunosenescence and age-associated risk of chronic disease. / 12.2015 / PubMed
Are Performance Measures Necessary to Predict Loss of Independence in Elderly People? / 01.2016 / PubMed / Full text

AMPH

Effects of amphetamine exposure during adolescence on behavior and prelimbic cortex neuron activity in adulthood. / 01.09.2018 / PubMed / Full text
The effects of amphetamine exposure on juvenile rats on the neuronal morphology of the limbic system at prepubertal, pubertal and postpubertal ages. / 11.2016 / PubMed / Full text
Amphetamine modulates brain signal variability and working memory in younger and older adults. / 16.06.2015 / PubMed / Full text
Adolescent exposure to cocaine, amphetamine, and methylphenidate cross-sensitizes adults to methamphetamine with drug- and sex-specific effects. / 15.03.2015 / PubMed / Full text

BMF

lncRNA-ES3/miR-34c-5p/BMF axis is involved in regulating high-glucose-induced calcification/senescence of VSMCs. / 17.01.2019 / PubMed / Full text
Aging, hematopoiesis, and the myelodysplastic syndromes. / 08.12.2017 / PubMed / Full text
Bone marrow fat unsaturation in young adults is not affected by present or childhood obesity, but increases with age: A pilot study. / 11.2015 / PubMed / Full text
Loss of the proapoptotic BH3-only protein BCL-2 modifying factor prolongs the fertile life span in female mice. / 04.2014 / PubMed / Full text

BPI

High TARC plasma levels confer protection to long living individuals by inducing M2 profile. / 01.2021 / PubMed / Full text
Circulating BPIFB4 Levels Associate With and Influence the Abundance of Reparative Monocytes and Macrophages in Long Living Individuals. / 2020 / PubMed / Full text
The effect of postural deformities on back function and pain in patients with Parkinson's disease. / 2019 / PubMed / Full text
The expression of the BPIFB4 and CXCR4 associates with sustained health in long-living individuals from Cilento-Italy. / 22.01.2017 / PubMed / Full text

CARF

Induction of Senescence in Cancer Cells by a Novel Combination of Cucurbitacin B and Withanone: Molecular Mechanism and Therapeutic Potential. / 22.05.2020 / PubMed / Full text
CARF is a multi-module regulator of cell proliferation and a molecular bridge between cellular senescence and carcinogenesis. / 09.2017 / PubMed / Full text
Collaborator of ARF (CARF) regulates proliferative fate of human cells by dose-dependent regulation of DNA damage signaling. / 27.06.2014 / PubMed / Full text
Molecular characterization of collaborator of ARF (CARF) as a DNA damage response and cell cycle checkpoint regulatory protein. / 01.04.2014 / PubMed / Full text

CASP3

Does cartilage ERα overexpression correlate with osteoarthritic chondrosenescence? Indications from [i]Labisia pumila[/i] OA mitigation. / 09.2019 / PubMed
Analysis of molecular networks and targets mining of Chinese herbal medicines on anti-aging. / 28.12.2016 / PubMed / Full text
Di-retinoid-pyridinium-ethanolamine (A2E) Accumulation and the Maintenance of the Visual Cycle Are Independent of Atg7-mediated Autophagy in the Retinal Pigmented Epithelium. / 27.11.2015 / PubMed / Full text
A genome-wide scan reveals important roles of DNA methylation in human longevity by regulating age-related disease genes. / 2015 / PubMed / Full text

CCL19

Age-Related Gliosis Promotes Central Nervous System Lymphoma through CCL19-Mediated Tumor Cell Retention. / 16.09.2019 / PubMed / Full text
Tumor-host signaling interaction reveals a systemic, age-dependent splenic immune influence on tumor development. / 03.11.2015 / PubMed / Full text
Differential Gene Expression Profiles Reflecting Macrophage Polarization in Aging and Periodontitis Gingival Tissues. / 2015 / PubMed / Full text
CD11c-Expressing B Cells Are Located at the T Cell/B Cell Border in Spleen and Are Potent APCs. / 01.07.2015 / PubMed / Full text

CCL21

CCL21/CCR7 axis regulating juvenile cartilage repair can enhance cartilage healing in adults. / 26.03.2019 / PubMed / Full text
Changes in expression of klotho affect physiological processes, diseases, and cancer. / 01.2018 / PubMed / Full text
Artery Tertiary Lymphoid Organs: Powerhouses of Atherosclerosis Immunity. / 2016 / PubMed / Full text
CD11c-Expressing B Cells Are Located at the T Cell/B Cell Border in Spleen and Are Potent APCs. / 01.07.2015 / PubMed / Full text

CCL3

Microglial translational profiling reveals a convergent APOE pathway from aging, amyloid, and tau. / 03.09.2018 / PubMed / Full text
Time-Dependent Changes in Local and Serum Levels of Inflammatory Cytokines as Markers for Incised Wound Aging of Skeletal Muscles. / 05.2018 / PubMed / Full text
Age-related pro-inflammatory and pro-angiogenic changes in human aqueous humor. / 2018 / PubMed / Full text
Changes in the expression of the Toll-like receptor system in the aging rat kidneys. / 2014 / PubMed / Full text

CCN1

Sodium tanshinone IIA sulfonate restrains fibrogenesis through induction of senescence in mice with induced deep endometriosis. / 09.2020 / PubMed / Full text
Inhibition of cellular communication network factor 1 (CCN1)-driven senescence slows down cartilage inflammaging and osteoarthritis. / 10.2020 / PubMed / Full text
The senescence-associated matricellular protein CCN1 in plasma of human subjects with idiopathic pulmonary fibrosis. / 01.2020 / PubMed / Full text
CCN1 (CYR61) and CCN3 (NOV) signaling drives human trophoblast cells into senescence and stimulates migration properties. / 03.03.2016 / PubMed / Full text

CD22

CD22 blockade restores homeostatic microglial phagocytosis in ageing brains. / 04.2019 / PubMed / Full text
Age-related changes in mRNA expression of selected surface receptors in lymphocytes of dairy calves. / 03.2018 / PubMed / Full text
Siglec-G Deficiency Leads to Autoimmunity in Aging C57BL/6 Mice. / 01.07.2015 / PubMed / Full text
Double negative (CD19 IgG IgD-CD27-) B lymphocytes: a new insight from telomerase in healthy elderly, in centenarian offspring and in Alzheimer's disease patients. / 11.2014 / PubMed / Full text

CES1

[Comparative Study of Hydrolase Activity in Skin with Liver and Intestine, and Its Aging Relation of Carboxylesterase Expression in Cynomolgus Monkey and Beagle Dog]. / 2019 / PubMed / Full text
Age-Dependent Absolute Abundance of Hepatic Carboxylesterases (CES1 and CES2) by LC-MS/MS Proteomics: Application to PBPK Modeling of Oseltamivir In Vivo Pharmacokinetics in Infants. / 02.2017 / PubMed / Full text
Identifying clinically relevant sources of variability: The clopidogrel challenge. / 02.2017 / PubMed / Full text
Age-Dependent Human Hepatic Carboxylesterase 1 (CES1) and Carboxylesterase 2 (CES2) Postnatal Ontogeny. / 07.2016 / PubMed / Full text

CLN3

SIRT6 histone deacetylase functions as a potential oncogene in human melanoma. / 09.2017 / PubMed / Full text
Age-dependent alterations in neuronal activity in the hippocampus and visual cortex in a mouse model of Juvenile Neuronal Ceroid Lipofuscinosis (CLN3). / 04.2017 / PubMed / Full text
Photoreceptor phagosome processing defects and disturbed autophagy in retinal pigment epithelium of Cln3Δex1-6 mice modelling juvenile neuronal ceroid lipofuscinosis (Batten disease). / 15.12.2015 / PubMed / Full text
Finding the most appropriate mouse model of juvenile CLN3 (Batten) disease for therapeutic studies: the importance of genetic background and gender. / 04.2015 / PubMed / Full text

CPE

Cross-Sectional and Cumulative Longitudinal Central Nervous System Penetration Effectiveness Scores Are Not Associated With Neurocognitive Impairment in a Well Treated Aging Human Immunodeficiency Virus-Positive Population in Switzerland. / 07.2019 / PubMed / Full text
COCOA (Theobroma cacao) Polyphenol-Rich Extract Increases the Chronological Lifespan of Saccharomyces cerevisiae. / 2016 / PubMed
The choroid plexus-cerebrospinal fluid interface in Alzheimer's disease: more than just a barrier. / 04.2016 / PubMed / Full text
Characterization of Clostridium perfringens in the feces of adult horses and foals with acute enterocolitis. / 01.2014 / PubMed / Full text

CRY1

Karyopherin Alpha 2-Expressing Pancreatic Duct Glands and Intra-Islet Ducts in Aged Diabetic C414A-Mutant-CRY1 Transgenic Mice. / 2019 / PubMed / Full text
Investigating circadian clock gene expression in human tendon biopsies from acute exercise and immobilization studies. / 06.2019 / PubMed / Full text
Is the aging human ovary still ticking?: Expression of clock-genes in luteinized granulosa cells of young and older women. / 21.11.2018 / PubMed / Full text
Circadian Clock Control by Polyamine Levels through a Mechanism that Declines with Age. / 03.11.2015 / PubMed / Full text

CTCF

New targeted approaches for epigenetic age predictions. / 24.06.2020 / PubMed / Full text
Genetic Insights Into Frailty: Association of 9p21-23 Locus With Frailty. / 2018 / PubMed / Full text
HMGB2 Loss upon Senescence Entry Disrupts Genomic Organization and Induces CTCF Clustering across Cell Types. / 17.05.2018 / PubMed / Full text
Polycomb repressive complex 2 epigenomic signature defines age-associated hypermethylation and gene expression changes. / 2015 / PubMed / Full text

CXCR1

Harmful neutrophil subsets in patients with ischemic stroke: Association with disease severity. / 07.2019 / PubMed / Full text
Knockdown of IL-8 Provoked Premature Senescence of Placenta-Derived Mesenchymal Stem Cells. / 15.06.2017 / PubMed / Full text
The matrikine N-acetylated proline-glycine-proline induces premature senescence of nucleus pulposus cells via CXCR1-dependent ROS accumulation and DNA damage and reinforces the destructive effect of these cells on homeostasis of intervertebral discs. / 01.2017 / PubMed / Full text
Habitual physical activity is associated with the maintenance of neutrophil migratory dynamics in healthy older adults. / 08.2016 / PubMed / Full text

CYP17A1

Combined toxicity of endosulfan and phenanthrene mixtures and induced molecular changes in adult Zebrafish (Danio rerio). / 03.2018 / PubMed / Full text
Testicular gene expression of steroidogenesis-related factors in prepubertal, postpubertal, and aging dogs. / 01.03.2017 / PubMed / Full text
CYP17A1 Enzyme Activity Is Linked to Ambulatory Blood Pressure in a Family-Based Population Study. / 04.2016 / PubMed / Full text
Sequence analysis of six blood pressure candidate regions in 4,178 individuals: the Cohorts for Heart and Aging Research in Genomic Epidemiology (CHARGE) targeted sequencing study. / 2014 / PubMed / Full text

CYP3A5

Effect of Age and Allele Variants of CYP3A5, CYP3A4, and POR Genes on the Pharmacokinetics of Cyclosporin A in Pediatric Renal Transplant Recipients From Serbia. / 12.2017 / PubMed / Full text
Analysis of the variability of the pharmacokinetics of multiple drugs in young adult and elderly subjects and its implications for acceptable daily exposures and cleaning validation limits. / 06.2017 / PubMed / Full text
Donor CYP3A5 genotype influences tacrolimus disposition on the first day after paediatric liver transplantation. / 06.2017 / PubMed / Full text
Relationship between mRNA expression levels of CYP3A4, CYP3A5 and SXR in peripheral mononuclear blood cells and aging in young kidney transplant recipients under tacrolimus treatment. / 2015 / PubMed / Full text

DICER1

DICER1: A Key Player in Rheumatoid Arthritis, at the Crossroads of Cellular Stress, Innate Immunity, and Chronic Inflammation in Aging. / 2018 / PubMed / Full text
Profiling of m6A RNA modifications identified an age-associated regulation of AGO2 mRNA stability. / 06.2018 / PubMed / Full text
Metformin-mediated increase in DICER1 regulates microRNA expression and cellular senescence. / 06.2016 / PubMed / Full text
Radiographic screening of infants and young children with genetic predisposition for rare malignancies: DICER1 mutations and pleuropulmonary blastoma. / 04.2015 / PubMed / Full text

DYRK1A

Altered age-linked regulation of plasma DYRK1A in elderly cognitive complainers (INSIGHT-preAD study) with high brain amyloid load. / 2020 / PubMed / Full text
Normalizing the gene dosage of Dyrk1A in a mouse model of Down syndrome rescues several Alzheimer's disease phenotypes. / 10.2017 / PubMed / Full text
The protein kinase MBK-1 contributes to lifespan extension in [i]daf-2[/i] mutant and germline-deficient [i]Caenorhabditis elegans[/i]. / 25.05.2017 / PubMed / Full text
Low dose EGCG treatment beginning in adolescence does not improve cognitive impairment in a Down syndrome mouse model. / 11.2015 / PubMed / Full text

EBP

National dissemination of multiple evidence-based disease prevention programs: reach to vulnerable older adults. / 2014 / PubMed / Full text
Roles for education in development and implementation of evidence-based practices for community programs for older adults. / 2015 / PubMed / Full text
Methods for streamlining intervention fidelity checklists: an example from the chronic disease self-management program. / 2014 / PubMed / Full text
Age-related sensitivity to endotoxin-induced liver inflammation: Implication of inflammasome/IL-1β for steatohepatitis. / 08.2015 / PubMed / Full text

EFEMP1

A novel age-related venous amyloidosis derived from EGF-containing fibulin-like extracellular matrix protein 1. / 04.2019 / PubMed / Full text
Mutant Fibulin-3 Causes Proteoglycan Accumulation and Impaired Diffusion Across Bruch's Membrane. / 01.06.2017 / PubMed / Full text
Extended Multiplexing of Tandem Mass Tags (TMT) Labeling Reveals Age and High Fat Diet Specific Proteome Changes in Mouse Epididymal Adipose Tissue. / 05.2017 / PubMed / Full text
Role of Fibulin 3 in Aging-Related Joint Changes and Osteoarthritis Pathogenesis in Human and Mouse Knee Cartilage. / 03.2017 / PubMed / Full text

EPHA1

Whole-Exome Sequencing of an Exceptional Longevity Cohort. / 16.08.2019 / PubMed / Full text
Late Onset Alzheimer's Disease Risk Variants in Cognitive Decline: The PATH Through Life Study. / 2017 / PubMed / Full text
Association and interaction effects of Alzheimer's disease-associated genes and lifestyle on cognitive aging in older adults in a Taiwanese population. / 11.04.2017 / PubMed / Full text
Gene-based aggregate SNP associations between candidate AD genes and cognitive decline. / 04.2016 / PubMed / Full text

ESR2

Inter-Regional Variations in Gene Expression and Age-Related Cortical Thinning in the Adolescent Brain. / 01.04.2018 / PubMed / Full text
Age- and menopause-related differences in subcutaneous adipose tissue estrogen receptor mRNA expression. / 05.2017 / PubMed / Full text
Differential roles of estrogen receptors, ESR1 and ESR2, in adult rat spermatogenesis. / 15.06.2016 / PubMed / Full text
Effects of Age and Estradiol on Gene Expression in the Rhesus Macaque Hypothalamus. / 2015 / PubMed / Full text

FABP4

Senescence Alters PPARγ (Peroxisome Proliferator-Activated Receptor Gamma)-Dependent Fatty Acid Handling in Human Adipose Tissue Microvascular Endothelial Cells and Favors Inflammation. / 05.2018 / PubMed / Full text
Endothelial APLNR regulates tissue fatty acid uptake and is essential for apelin's glucose-lowering effects. / 13.09.2017 / PubMed / Full text
Determination of the Mechanisms that Cause Sarcopenia through cDNA Microarray. / 2017 / PubMed / Full text
Bariatric surgery and diet-induced long-term caloric restriction protect subcutaneous adipose-derived stromal/progenitor cells and prolong their life span in formerly obese humans. / 08.2014 / PubMed / Full text

FBL

APPLICATION OF A NOVEL QUANTITATIVE TRACTOGRAPHY-BASED ANALYSIS OF DIFFUSION TENSOR IMAGING TO EXAMINE FIBER BUNDLE LENGTH IN HUMAN CEREBRAL WHITE MATTER. / 04.2016 / PubMed / Full text
Cognitive reserve moderates the relationship between neuropsychological performance and white matter fiber bundle length in healthy older adults. / 06.2017 / PubMed / Full text
Fiber bundle length and cognition: a length-based tractography MRI study. / 12.2015 / PubMed / Full text
White matter changes with age utilizing quantitative diffusion MRI. / 15.07.2014 / PubMed / Full text

FKBP5

Epigenetic upregulation of FKBP5 by aging and stress contributes to NF-κB-driven inflammation and cardiovascular risk. / 04.06.2019 / PubMed / Full text
The common functional FKBP5 variant rs1360780 is associated with altered cognitive function in aged individuals. / 21.10.2014 / PubMed / Full text
Age-associated epigenetic upregulation of the FKBP5 gene selectively impairs stress resiliency. / 2014 / PubMed / Full text
Role of FKBP5 in emotion processing: results on amygdala activity, connectivity and volume. / 2015 / PubMed / Full text

GALT

Microanatomical dissection of human intestinal T-cell immunity reveals site-specific changes in gut-associated lymphoid tissues over life. / 03.2019 / PubMed / Full text
Dietary Animal Plasma Proteins Improve the Intestinal Immune Response in Senescent Mice. / 11.12.2017 / PubMed / Full text
Ageing combines CD4 T cell lymphopenia in secondary lymphoid organs and T cell accumulation in gut associated lymphoid tissue. / 2014 / PubMed / Full text
Influence of ageing on the gastrointestinal environment of the rat and its implications for drug delivery. / 01.10.2014 / PubMed / Full text

GCLM

Silencing Bach1 alters aging-related changes in the expression of Nrf2-regulated genes in primary human bronchial epithelial cells. / 15.09.2019 / PubMed / Full text
Ontogeny and aging of Nrf2 pathway genes in livers of rats. / 15.06.2018 / PubMed / Full text
Sulfur amino acid restriction-induced changes in redox-sensitive proteins are associated with slow protein synthesis rates. / 04.2018 / PubMed / Full text
Aging-related decline in the induction of Nrf2-regulated antioxidant genes in human bronchial epithelial cells. / 04.2018 / PubMed / Full text

GIT2

Multidimensional informatic deconvolution defines gender-specific roles of hypothalamic GIT2 in aging trajectories. / 12.2019 / PubMed / Full text
GIT2-A keystone in ageing and age-related disease. / 05.2018 / PubMed / Full text
Genomic deletion of GIT2 induces a premature age-related thymic dysfunction and systemic immune system disruption. / 04.03.2017 / PubMed / Full text
GIT2 Acts as a Systems-Level Coordinator of Neurometabolic Activity and Pathophysiological Aging. / 2015 / PubMed / Full text

GLS

Normal Values and Growth-Related Changes of Left Ventricular Volumes, Stress, and Strain in Healthy Children Measured by 3-Dimensional Echocardiography. / 15.07.2018 / PubMed / Full text
Future Perspectives for Management of Stage A Heart Failure. / 01.07.2018 / PubMed / Full text
Reference Ranges of Left Ventricular Strain Measures by Two-Dimensional Speckle-Tracking Echocardiography in Children: A Systematic Review and Meta-Analysis. / 03.2016 / PubMed / Full text
Cardiorespiratory fitness modifies the relationship between myocardial function and cerebral blood flow in older adults. / 01.05.2016 / PubMed / Full text

GRK2

G protein-coupled receptor kinase 2 modifies the ability of Caenorhabditis elegans to survive oxidative stress. / 16.10.2020 / PubMed / Full text
G protein coupled receptor kinases modulate Caenorhabditis elegans reactions to heat stresses. / 01.10.2020 / PubMed / Full text
Loss of dynamic regulation of G protein-coupled receptor kinase 2 by nitric oxide leads to cardiovascular dysfunction with aging. / 01.05.2020 / PubMed / Full text
Senescent Cells Differentially Translate Senescence-Related mRNAs Via Ribosome Heterogeneity. / 18.06.2019 / PubMed / Full text

GSTT1

Age-associated changes in GSH S-transferase gene/proteins in livers of rats. / 12.2018 / PubMed / Full text
Lead-Related Genetic Loci, Cumulative Lead Exposure and Incident Coronary Heart Disease: The Normative Aging Study. / 2016 / PubMed / Full text
Effects of APOE rs429358, rs7412 and GSTM1/GSTT1 Polymorphism on Plasma and Erythrocyte Antioxidant Parameters and Cognition in Old Chinese Adults. / 24.09.2015 / PubMed / Full text
[Frequency of gene polymorphic variants (phase II) of biotransformation of GSTT1 and GSTM1 xenobiotics among long-livers (Precarpathian region)]. / 2013 / PubMed

HAL

Comparison of haloperidol, non-haloperidol antipsychotics, and no pharmacotherapy for the management of delirium in an inpatient geriatric palliative care population. / 06-09.2018 / PubMed / Full text
Acute and long-term effects of haloperidol on surgery-induced neuroinflammation and cognitive deficits in aged rats. / 06.2019 / PubMed / Full text
Histone deacetylase inhibitors reverse age-related increases in side effects of haloperidol in mice. / 08.2017 / PubMed / Full text
Differential effects of intermittent versus continuous haloperidol treatment throughout adolescence on haloperidol sensitization and social behavior in adulthood. / 03.10.2014 / PubMed / Full text

HCN2

Characteristics of hyperpolarization-activated cyclic nucleotide-gated channels in dorsal root ganglion neurons at different ages and sizes. / 11.11.2015 / PubMed / Full text
Age-associated expression of HCN channel isoforms in rat sinoatrial node. / 02.2016 / PubMed / Full text
Altered expression of hyperpolarization-activated cyclic nucleotide-gated channels and microRNA-1 and -133 in patients with age-associated atrial fibrillation. / 09.2015 / PubMed / Full text
Differential expression of hyperpolarization-activated cyclic nucleotide-gated channel subunits during hippocampal development in the mouse. / 27.02.2015 / PubMed / Full text

HIRA

Pak2 kinase promotes cellular senescence and organismal aging. / 02.07.2019 / PubMed / Full text
ChIP-Sequencing to Map the Epigenome of Senescent Cells Using Benzonase Endonuclease. / 2016 / PubMed / Full text
O-linked N-acetylglucosamine transferase (OGT) interacts with the histone chaperone HIRA complex and regulates nucleosome assembly and cellular senescence. / 07.06.2016 / PubMed / Full text
HIRA orchestrates a dynamic chromatin landscape in senescence and is required for suppression of neoplasia. / 15.12.2014 / PubMed / Full text

HMGA2

4D Genome Rewiring during Oncogene-Induced and Replicative Senescence. / 07.05.2020 / PubMed / Full text
The protective effects of HMGA2 in the senescence process of bone marrow-derived mesenchymal stromal cells. / 04.2020 / PubMed / Full text
Epigallocatechin-3-gallate and BIX-01294 have different impact on epigenetics and senescence modulation in acute and chronic myeloid leukemia cells. / 05.11.2018 / PubMed / Full text
Molecular differences between stromal cell populations from deciduous and permanent human teeth. / 18.04.2015 / PubMed / Full text

HMGCR

Cholesterol Homeostasis: An In Silico Investigation into How Aging Disrupts Its Key Hepatic Regulatory Mechanisms. / 30.09.2020 / PubMed / Full text
Artesunate inhibits the mevalonate pathway and promotes glioma cell senescence. / 01.2020 / PubMed / Full text
Reactive oxygen species-induced changes in glucose and lipid metabolism contribute to the accumulation of cholesterol in the liver during aging. / 04.2019 / PubMed / Full text
The Age-dependent Elevation of miR-335-3p Leads to Reduced Cholesterol and Impaired Memory in Brain. / 15.10.2018 / PubMed / Full text

HSPA8

Influence of Normal Aging on Brain Autophagy: A Complex Scenario. / 2019 / PubMed / Full text
Nitric oxide contributes to protein homeostasis by S-nitrosylations of the chaperone HSPA8 and the ubiquitin ligase UBE2D. / 01.2019 / PubMed / Full text
Cerebrospinal Fluid Concentration of Key Autophagy Protein Lamp2 Changes Little During Normal Aging. / 2018 / PubMed / Full text
Age-Related Decrease in Heat Shock 70-kDa Protein 8 in Cerebrospinal Fluid Is Associated with Increased Oxidative Stress. / 2016 / PubMed / Full text

ID1

Commentary on Some Recent Theses Relevant to Combating Aging: April 2019. / 04.2019 / PubMed / Full text
ER stress and distinct outputs of the IRE1α RNase control proliferation and senescence in response to oncogenic Ras. / 12.09.2017 / PubMed / Full text
Expansion of adipose tissue-derived stromal cells at "physiologic" hypoxia attenuates replicative senescence. / 06.2017 / PubMed / Full text
Endoglin overexpression mediates gastric cancer peritoneal dissemination by inducing mesothelial cell senescence. / 05.2016 / PubMed / Full text

IFNG

Glutathione Peroxidase 3 Delivered by hiPSC-MSCs Ameliorated Hepatic IR Injury via Inhibition of Hepatic Senescence. / 2018 / PubMed / Full text
Impact of aging on host immune response and survival in melanoma: an analysis of 3 patient cohorts. / 19.10.2016 / PubMed / Full text
Age-related profiling of DNA methylation in CD8 T cells reveals changes in immune response and transcriptional regulator genes. / 19.08.2015 / PubMed / Full text
Lifespan of mice and primates correlates with immunoproteasome expression. / 05.2015 / PubMed / Full text

IGFBP2

Intracellular Insulin-like growth factor binding protein 2 (IGFBP2) contributes to the senescence of keratinocytes in psoriasis by stabilizing cytoplasmic p21. / 17.04.2020 / PubMed / Full text
TMT-Based Quantitative Proteomic Analysis Reveals Proteomic Changes Involved in Longevity. / 07.2019 / PubMed / Full text
IGFBP-2 and aging: a 20-year longitudinal study on IGFBP-2, IGF-I, BMI, insulin sensitivity and mortality in an aging population. / 01.02.2019 / PubMed / Full text
Proteomic profiling of follicle fluids after superstimulation in one-month-old lambs. / 02.2018 / PubMed / Full text

IGFBP5

Intracellular Heat Shock Protein 70 Deficiency in Pulmonary Fibrosis. / 06.2019 / PubMed / Full text
Blunted satellite cell response is associated with dysregulated IGF-1 expression after exercise with age. / 10.2018 / PubMed / Full text
Material-induced Senescence (MIS): Fluidity Induces Senescent Type Cell Death of Lung Cancer Cells via Insulin-Like Growth Factor Binding Protein 5. / 2017 / PubMed / Full text
Transcriptomic profiling suggests a role for IGFBP5 in premature senescence of endothelial cells after chronic low dose rate irradiation. / 07.2014 / PubMed / Full text

IGFBP7

Reprogramming of human fibroblasts into osteoblasts by insulin-like growth factor-binding protein 7. / 03.2020 / PubMed / Full text
Unique sex- and age-dependent effects in protective pathways in acute kidney injury. / 01.09.2017 / PubMed / Full text
A-to-I RNA editing of the IGFBP7 transcript increases during aging in porcine brain tissues. / 21.10.2016 / PubMed / Full text
Emerging role of insulin-like growth factor-binding protein 7 in hepatocellular carcinoma. / 2014 / PubMed / Full text

INSL3

Effect of Thyroxine Replacement on Leydig Cell and Sertoli Cell Function in Men with Hypothyroidism. / 05-06.2020 / PubMed / Full text
Age related and seasonal changes of plasma concentrations of insulin-like peptide 3 and testosterone from birth to early-puberty in Thoroughbred male horses. / 01.07.2019 / PubMed / Full text
Plasma insulin-like peptide 3 concentrations are acutely regulated by luteinizing hormone in pubertal Japanese Black beef bulls. / 12.2015 / PubMed / Full text
INSL3 stimulates spermatogonial differentiation in testis of adult zebrafish (Danio rerio). / 02.2016 / PubMed / Full text

IPP

Toxic effect of the novel chiral insecticide IPP and its biodegradation intermediate in nematode Caenorhabditis elegans. / 30.11.2018 / PubMed / Full text
The inositol pyrophosphate pathway in health and diseases. / 05.2018 / PubMed / Full text
Integrin-linked kinase: A new actor in the ageing process? / 15.12.2017 / PubMed / Full text
Efficacy of a computer-based cognitive training program in older people with subjective memory complaints: a randomized study. / 01.2018 / PubMed / Full text

IRF8

IRF8 induces senescence of lung cancer cells to exert its tumor suppressive function. / 12.2019 / PubMed / Full text
Epigenome-wide exploratory study of monozygotic twins suggests differentially methylated regions to associate with hand grip strength. / 10.2019 / PubMed / Full text
Aging impairs both primary and secondary RIG-I signaling for interferon induction in human monocytes. / 12.12.2017 / PubMed / Full text
Microglia recapitulate a hematopoietic master regulator network in the aging human frontal cortex. / 08.2015 / PubMed / Full text

ITGA2B

Effect of adding B-vitamins to vitamin D and calcium supplementation on CpG methylation of epigenetic aging markers. / 04.2018 / PubMed / Full text
Plasma Amyloid Beta 1-42 and DNA Methylation Pattern Predict Accelerated Aging in Young Subjects with Down Syndrome. / 12.2016 / PubMed / Full text
Developing a DNA methylation assay for human age prediction in blood and bloodstain. / 07.2015 / PubMed / Full text
Aging of blood can be tracked by DNA methylation changes at just three CpG sites. / 03.02.2014 / PubMed / Full text

KCNB1

Oxidation of KCNB1 potassium channels in the murine brain during aging is associated with cognitive impairment. / 14.05.2019 / PubMed / Full text
Oxidation of KCNB1 Potassium Channels Causes Neurotoxicity and Cognitive Impairment in a Mouse Model of Traumatic Brain Injury. / 26.10.2016 / PubMed / Full text
Oxidation of K( ) Channels in Aging and Neurodegeneration. / 03.2016 / PubMed / Full text
Oxidation of KCNB1 K( ) channels in central nervous system and beyond. / 26.05.2014 / PubMed / Full text

KISS1

Kisspeptin level in the aging ovary is regulated by the sympathetic nervous system. / 01.2017 / PubMed / Full text
Kisspeptin across the human lifespan:evidence from animal studies and beyond. / 06.2016 / PubMed / Full text
Effects of Age and Estradiol on Gene Expression in the Rhesus Macaque Hypothalamus. / 2015 / PubMed / Full text
[Profiles of reproduction-related mRNA expressions in hypothalamus of female mice with advancing age]. / 17.12.2013 / PubMed

L1CAM

Glioma malignancy is linked to interdependent and inverse AMOG and L1 adhesion molecule expression. / 12.09.2019 / PubMed / Full text
Induction, regulation and roles of neural adhesion molecule L1CAM in cellular senescence. / 28.03.2018 / PubMed / Full text
Cerebrospinal fluid biomarkers of infantile congenital hydrocephalus. / 2017 / PubMed / Full text
Neuropsin Expression Correlates with Dendritic Marker MAP2c Level in Different Brain Regions of Aging Mice. / 2015 / PubMed / Full text

LAMP1

Differential accumulation of storage bodies with aging defines discrete subsets of microglia in the healthy brain. / 24.06.2020 / PubMed / Full text
A pH probe inhibits senescence in mesenchymal stem cells. / 07.12.2018 / PubMed / Full text
Alterations in Corneal Sensory Nerves During Homeostasis, Aging, and After Injury in Mice Lacking the Heparan Sulfate Proteoglycan Syndecan-1. / 01.10.2017 / PubMed / Full text
Photoreceptor phagosome processing defects and disturbed autophagy in retinal pigment epithelium of Cln3Δex1-6 mice modelling juvenile neuronal ceroid lipofuscinosis (Batten disease). / 15.12.2015 / PubMed / Full text

LIF

Aminopeptidase N expression in the endometrium could affect endometrial receptivity. / 25.06.2019 / PubMed / Full text
Efficacy of leukemia inhibitory factor as a therapeutic for permanent large vessel stroke differs among aged male and female rats. / 15.03.2019 / PubMed / Full text
Assaying human neutrophil elastase activity by capillary zone electrophoresis combined with laser-induced fluorescence. / 06.11.2015 / PubMed / Full text
iPSCs, aging and age-related diseases. / 25.09.2014 / PubMed / Full text

LONP1

Mitochondria organize the cellular proteostatic response and promote cellular senescence. / 15.03.2019 / PubMed / Full text
A mitochondrial FUNDC1/HSC70 interaction organizes the proteostatic stress response at the risk of cell morbidity. / 01.02.2019 / PubMed / Full text
Mitochondrial Lon protease in human disease and aging: Including an etiologic classification of Lon-related diseases and disorders. / 11.2016 / PubMed / Full text
Lon protease: A key enzyme controlling mitochondrial bioenergetics in cancer. / 10-12.2014 / PubMed / Full text

MAOA

Inflammasome-driven catecholamine catabolism in macrophages blunts lipolysis during ageing. / 05.10.2017 / PubMed / Full text
Age-dependent role of pre- and perinatal factors in interaction with genes on ADHD symptoms across adolescence. / 07.2017 / PubMed / Full text
Candidate SNP associations of optimism and resilience in older adults: exploratory study of 935 community-dwelling adults. / 10.2014 / PubMed / Full text
Investigation of association of serotonin transporter and monoamine oxidase-A genes with Alzheimer's disease and depression in the VITA study cohort: a 90-month longitudinal study. / 03.2014 / PubMed / Full text

MAPKAPK2

Quantitative In Vivo Proteomics of Metformin Response in Liver Reveals AMPK-Dependent and -Independent Signaling Networks. / 03.12.2019 / PubMed / Full text
Cell fate regulation by reticulon-4 in human prostate cancers. / 07.2019 / PubMed / Full text
Rapamycin and the inhibition of the secretory phenotype. / 08.2017 / PubMed / Full text
Microwave-Assisted Synthesis of a MK2 Inhibitor by Suzuki-Miyaura Coupling for Study in Werner Syndrome Cells. / 03.06.2015 / PubMed / Full text

MARCKS

Ser46-Phosphorylated MARCKS Is a Marker of Neurite Degeneration at the Pre-aggregation Stage in PD/DLB Pathology. / 07-08.2018 / PubMed / Full text
MARCKS contributes to stromal cancer-associated fibroblast activation and facilitates ovarian cancer metastasis. / 21.06.2016 / PubMed / Full text
MARCKS-dependent mucin clearance and lipid metabolism in ependymal cells are required for maintenance of forebrain homeostasis during aging. / 10.2015 / PubMed / Full text
The novel protein kinase C epsilon isoform at the adult neuromuscular synapse: location, regulation by synaptic activity-dependent muscle contraction through TrkB signaling and coupling to ACh release. / 10.02.2015 / PubMed / Full text

MCL1

MCL1 gene silencing promotes senescence and apoptosis of glioma cells via inhibition of the PI3K/Akt signaling pathway. / 01.2019 / PubMed / Full text
A lowered 26S proteasome activity correlates with mantle lymphoma cell lines resistance to genotoxic stress. / 10.08.2017 / PubMed / Full text
Sperm-associated antigen 9 (SPAG9) promotes the survival and tumor growth of triple-negative breast cancer cells. / 10.2016 / PubMed / Full text
RHEB: a potential regulator of chondrocyte phenotype for cartilage tissue regeneration. / 09.2017 / PubMed / Full text

MCM2

Trophoblast type-specific expression of senescence markers in the human placenta. / 15.09.2019 / PubMed / Full text
Changes in MCM2-7 proteins at senescence. / 27.07.2019 / PubMed / Full text
Evaluation of Nestin Expression in the Developing and Adult Mouse Inner Ear. / 01.10.2016 / PubMed / Full text
A septo-temporal molecular gradient of sfrp3 in the dentate gyrus differentially regulates quiescent adult hippocampal neural stem cell activation. / 04.09.2015 / PubMed / Full text

MTMR14

EDTP/MTMR14: A novel target for improved survivorship to prolonged anoxia and cellular protein aggregates. / 13.07.2019 / PubMed / Full text
Downregulation of EDTP in glial cells suppresses polyglutamine protein aggregates and extends lifespan in Drosophila melanogaster. / 16.02.2019 / PubMed / Full text
AUTEN-67, an autophagy-enhancing drug candidate with potent antiaging and neuroprotective effects. / 2016 / PubMed / Full text
Novel excitation-contraction coupling related genes reveal aspects of muscle weakness beyond atrophy-new hopes for treatment of musculoskeletal diseases. / 2014 / PubMed / Full text

NCL

Factors Affecting Microvascular Responses in the Bulbar Conjunctiva in Habitual Contact Lens Wearers. / 01.08.2018 / PubMed / Full text
Small nucleoli are a cellular hallmark of longevity. / 30.08.2017 / PubMed / Full text
Mesterolone treatment of aging male syndrome improves lower urinary tract symptoms. / 12.2014 / PubMed
Retinal function in aging homozygous Cln3 (Δex7/8) knock-in mice. / 2014 / PubMed / Full text

NF1

The SNF1 Kinase Ubiquitin-associated Domain Restrains Its Activation, Activity, and the Yeast Life Span. / 19.06.2015 / PubMed / Full text
NF1 loss induces senescence during human melanocyte differentiation in an iPSC-based model. / 07.2015 / PubMed / Full text
TGF-β/NF1/Smad4-mediated suppression of ANT2 contributes to oxidative stress in cellular senescence. / 12.2014 / PubMed / Full text
Neuropsychological impairments in elderly Neurofibromatosis type 1 patients. / 04.2014 / PubMed / Full text

NLRC4

Hyperglycemia-induced inflamm-aging accelerates gingival senescence via NLRC4 phosphorylation. / 06.12.2019 / PubMed / Full text
Contribution of the inflammasome to inflammaging. / 2018 / PubMed / Full text
Expression of specific inflammasome gene modules stratifies older individuals into two extreme clinical and immunological states. / 02.2017 / PubMed / Full text
The Expression Changes of Inflammasomes in the Aging Rat Kidneys. / 06.2016 / PubMed / Full text

NPC2

Attenuation of the Niemann-Pick type C2 disease phenotype by intracisternal administration of an AAVrh.10 vector expressing Npc2. / 08.2018 / PubMed / Full text
Quantification of age-related changes of α-tocopherol in lysosomal membranes in murine tissues and human fibroblasts. / 05.2016 / PubMed / Full text
Systemic administration of 2-hydroxypropyl-β-cyclodextrin to symptomatic Npc1-deficient mice slows cholesterol sequestration in the major organs and improves liver function. / 10.2014 / PubMed / Full text
Niemann-Pick C disease gene mutations and age-related neurodegenerative disorders. / 2013 / PubMed / Full text

NRG1

Effects of neuregulin-1 administration on neurogenesis in the adult mouse hippocampus, and characterization of immature neurons along the septotemporal axis. / 29.07.2016 / PubMed / Full text
Neuregulin-1 Administration Protocols Sufficient for Stimulating Cardiac Regeneration in Young Mice Do Not Induce Somatic, Organ, or Neoplastic Growth. / 2016 / PubMed / Full text
Neuregulin 1 improves glucose tolerance in adult and old rats. / 04.2016 / PubMed / Full text
Disruption of hippocampal neuregulin 1-ErbB4 signaling contributes to the hippocampus-dependent cognitive impairment induced by isoflurane in aged mice. / 07.2014 / PubMed / Full text

ORC1

The hyperornithinemia-hyperammonemia-homocitrullinuria syndrome. / 11.03.2015 / PubMed / Full text
The role of TORC1 in muscle development in Drosophila. / 13.04.2015 / PubMed / Full text
mTOR signaling in aging and neurodegeneration: At the crossroad between metabolism dysfunction and impairment of autophagy. / 12.2015 / PubMed / Full text
Drug synergy drives conserved pathways to increase fission yeast lifespan. / 2015 / PubMed / Full text

OXTR

Association of oxytocin levels and oxytocin receptor gene polymorphism (rs2254298) with cardiovascular risk factors in Brazilian elderly from Primary Health Care. / 09-10.2019 / PubMed / Full text
Impact of housing conditions on social behavior, neuroimmune markers, and oxytocin receptor expression in aged male and female Fischer 344 rats. / 08.2019 / PubMed / Full text
Associations between oxytocin receptor gene (OXTR) methylation, plasma oxytocin, and attachment across adulthood. / 02.2019 / PubMed / Full text
DNA methylation and single nucleotide variants in the brain-derived neurotrophic factor (BDNF) and oxytocin receptor (OXTR) genes are associated with anxiety/depression in older women. / 2015 / PubMed / Full text

PAK1

1,2,3-Triazolyl ester of ketorolac (15K): Boosting both heat-endurance and lifespan of C. elegans by down-regulating PAK1 at nM levels. / 2018 / PubMed / Full text
From bench (laboratory) to bed (hospital/home): How to explore effective natural and synthetic PAK1-blockers/longevity-promoters for cancer therapy. / 15.12.2017 / PubMed / Full text
Effect of Okinawa Propolis on PAK1 Activity, Caenorhabditis elegans Longevity, Melanogenesis, and Growth of Cancer Cells. / 13.07.2016 / PubMed / Full text
Several herbal compounds in Okinawa plants directly inhibit the oncogenic/aging kinase PAK1. / 12.2014 / PubMed / Full text

PARK7

The genetic component of human longevity: New insights from the analysis of pathway-based SNP-SNP interactions. / 06.2018 / PubMed / Full text
The oxidized thiol proteome in aging and cataractous mouse and human lens revealed by ICAT labeling. / 04.2017 / PubMed / Full text
Unbiased analysis of senescence associated secretory phenotype (SASP) to identify common components following different genotoxic stresses. / 07.2016 / PubMed / Full text
Life-time expression of the proteins peroxiredoxin, beta-synuclein, [[PARK7]]/DJ-1, and stathmin in the primary visual and primary somatosensory cortices in rats. / 2015 / PubMed / Full text

PDC

The mitochondrial translocase of the inner membrane PaTim54 is involved in defense response and longevity in Podospora anserina. / 11.2019 / PubMed / Full text
Neuron-specific knockdown of Drosophila PDHB induces reduction of lifespan, deficient locomotive ability, abnormal morphology of motor neuron terminals and photoreceptor axon targeting. / 15.05.2018 / PubMed / Full text
Assessing degradation of composite resin cements during artificial aging by Martens hardness. / 19.05.2017 / PubMed / Full text
Sevoflurane anesthesia induces neither contextual fear memory impairment nor alterations in local population connectivity of medial prefrontal cortex local field potentials networks in aged rats. / 08.2016 / PubMed / Full text

PDE4D

Phosphodiesterase PDE4D Is Decreased in Frontal Cortex of Aged Rats and Positively Correlated With Working Memory Performance and Inversely Correlated With PKA Phosphorylation of Tau. / 2020 / PubMed / Full text
Compound D159687, a phosphodiesterase 4D inhibitor, induces weight and fat mass loss in aged mice without changing lean mass, physical and cognitive function. / 02.12.2018 / PubMed / Full text
The isozyme selective phosphodiesterase-4 inhibitor, ABI-4, attenuates the effects of lipopolysaccharide in human cells and rodent models of peripheral and CNS inflammation. / 08.2017 / PubMed / Full text
Effects of aging on gene expression and mitochondrial DNA in the equine oocyte and follicle cells. / 07.2015 / PubMed / Full text

PDF

Effects of MUL1 and PARKIN on the circadian clock, brain and behaviour in Drosophila Parkinson's disease models. / 28.05.2019 / PubMed / Full text
Drosophila Clock Is Required in Brain Pacemaker Neurons to Prevent Premature Locomotor Aging Independently of Its Circadian Function. / 01.2017 / PubMed / Full text
SnapShot: Neuronal Regulation of Aging. / 28.07.2016 / PubMed / Full text
Recent data on Mediterranean diet, cardiovascular disease, cancer, diabetes and life expectancy. / 2015 / PubMed / Full text

PFAS

Associations between serum concentrations of perfluoroalkyl substances and DNA methylation in women exposed through drinking water: A pilot study in Ronneby, Sweden. / 12.2020 / PubMed / Full text
Perfluorinated alkyl substances impede growth, reproduction, lipid metabolism and lifespan in Daphnia magna. / 01.10.2020 / PubMed / Full text
The effect of weathering on per- and polyfluoroalkyl substances (PFASs) from durable water repellent (DWR) clothing. / 06.2020 / PubMed / Full text
Longitudinal measures of perfluoroalkyl substances (PFAS) in serum of Gullah African Americans in South Carolina: 2003-2013. / 11.2015 / PubMed / Full text

PLAU

Identification of key genes and transcription factors in aging mesenchymal stem cells by DNA microarray data. / 15.04.2019 / PubMed / Full text
Towards frailty biomarkers: Candidates from genes and pathways regulated in aging and age-related diseases. / 11.2018 / PubMed / Full text
G protein-coupled receptor kinase 4-induced cellular senescence and its senescence-associated gene expression profiling. / 15.11.2017 / PubMed / Full text
Functional networks of aging markers in the glomeruli of IgA nephropathy: a new therapeutic opportunity. / 07.06.2016 / PubMed / Full text

PNP

Temporal Discrimination Thresholds and Proprioceptive Performance: Impact of Age and Nerve Conduction. / 2019 / PubMed / Full text
Polyneuropathy in Severely Obese Women Without Diabetes: Prevalence and Associated Factors. / 03.2019 / PubMed / Full text
Electrophysiological evidence for preserved primacy of lexical prediction in aging. / 08.2018 / PubMed / Full text
High prevalence of colonization of oral cavity by respiratory pathogens in frail older patients with oropharyngeal dysphagia. / 12.2015 / PubMed / Full text

POU5F1

Cell quality evaluation with gene expression analysis of spheroids (3D) and adherent (2D) adipose stem cells. / 24.10.2020 / PubMed / Full text
Autophagic homeostasis is required for the pluripotency of cancer stem cells. / 02.2017 / PubMed / Full text
Characterization of the POU5F1 Homologue in Nile Tilapia: From Expression Pattern to Biological Activity. / 15.09.2016 / PubMed / Full text
Determination phase at transition of gonocytes to spermatogonial stem cells improves establishment efficiency of spermatogonial stem cells in domestic cats. / 2015 / PubMed / Full text

PRC1

Timosaponin A-III inhibits oncogenic phenotype via regulation of PcG protein BMI1 in breast cancer cells. / 07.2018 / PubMed / Full text
Epigenetic factors Polycomb (Pc) and Suppressor of zeste (Su(z)2) negatively regulate longevity in Drosophila melanogaster. / 02.2018 / PubMed / Full text
The Polycomb Group Protein Pcgf1 Is Dispensable in Zebrafish but Involved in Early Growth and Aging. / 2016 / PubMed / Full text
CBX7 and miR-9 are part of an autoregulatory loop controlling p16(INK) (4a). / 12.2015 / PubMed / Full text

PREP

Genome-wide association study and annotating candidate gene networks affecting age at first calving in Nellore cattle. / 12.2017 / PubMed / Full text
Mechanism of Action of Prolyl Oligopeptidase (PREP) in Degenerative Brain Diseases: Has Peptidase Activity Only a Modulatory Role on the Interactions of PREP with Proteins? / 2017 / PubMed / Full text
Improving Pain Relief in Elder Patients (I-PREP): An Emergency Department Education and Quality Intervention. / 12.2016 / PubMed / Full text
Age and muscle-dependent variations in corticospinal excitability during standing tasks. / 2014 / PubMed / Full text

PTGS2

Senescent thyrocytes and thyroid tumor cells induce M2-like macrophage polarization of human monocytes via a PGE2-dependent mechanism. / 21.05.2019 / PubMed / Full text
Analysis of molecular networks and targets mining of Chinese herbal medicines on anti-aging. / 28.12.2016 / PubMed / Full text
Coordinated gene expression of neuroinflammatory and cell signaling markers in dorsolateral prefrontal cortex during human brain development and aging. / 2014 / PubMed / Full text
Coordination of gene expression of arachidonic and docosahexaenoic acid cascade enzymes during human brain development and aging. / 2014 / PubMed / Full text

RBP4

[Effects of different intensities exercise combined with resveratrol on RBP4 in aged obese rats]. / 08.05.2017 / PubMed / Full text
Transport of vitamin A across blood-tissue barriers is facilitated by STRA6. / 08.2016 / PubMed / Full text
[Adipose tissue, adipokines and aging]. / 02.2016 / PubMed
Transgenic Mice Overexpressing Serum Retinol-Binding Protein Develop Progressive Retinal Degeneration through a Retinoid-Independent Mechanism. / 08.2015 / PubMed / Full text

REC8

Effects of Heyan Kuntai Capsule () on Follicular Development and Oocyte Cohesin Levels in Aged Mice. / 10.2018 / PubMed / Full text
The effect of DHEA on apoptosis and cohesin levels in oocytes in aged mice. / 12.09.2017 / PubMed / Full text
Rec-8 dimorphism affects longevity, stress resistance and X-chromosome nondisjunction in C. elegans, and replicative lifespan in S. cerevisiae. / 2014 / PubMed / Full text
Age-related decrease of meiotic cohesins in human oocytes. / 2014 / PubMed / Full text

RHEB

The Rheb-TORC1 signaling axis functions as a developmental checkpoint. / 02.03.2020 / PubMed / Full text
Long-lived rodents reveal signatures of positive selection in genes associated with lifespan. / 03.2018 / PubMed / Full text
CGEF-1 regulates mTORC1 signaling during adult longevity and stress response in [i]C. elegans[/i]. / 09.02.2018 / PubMed / Full text
RHEB: a potential regulator of chondrocyte phenotype for cartilage tissue regeneration. / 09.2017 / PubMed / Full text

RPE65

Effects of Ranibizumab, Bevacizumab, and Aflibercept on Senescent Retinal Pigment Epithelial Cells. / 08.2018 / PubMed / Full text
Age-related macular degeneration phenotypes are associated with increased tumor necrosis-alpha and subretinal immune cells in aged Cxcr5 knockout mice. / 2017 / PubMed / Full text
The amino acid transporter SLC36A4 regulates the amino acid pool in retinal pigmented epithelial cells and mediates the mechanistic target of rapamycin, complex 1 signaling. / 04.2017 / PubMed / Full text
Thinning of the RPE and choroid associated with T lymphocyte recruitment in aged and light-challenged mice. / 2015 / PubMed / Full text

SATB1

Loss of SATB1 Induces p21-Dependent Cellular Senescence in Post-mitotic Dopaminergic Neurons. / 03.10.2019 / PubMed / Full text
Transcriptomic analysis of human IL-7 receptor alpha and effector memory CD8 T cells reveals an age-associated signature linked to influenza vaccine response in older adults. / 08.2019 / PubMed / Full text
Divergent SATB1 expression across human life span and tissue compartments. / 05.2019 / PubMed / Full text
Changes in expression of special AT-rich sequence binding protein 1 and phosphatase and tensin homologue in kidneys of diabetic rats during ageing. / 01.10.2018 / PubMed / Full text

SATB2

microRNA-31 inhibition partially ameliorates the deficiency of bone marrow stromal cells from cleidocranial dysplasia. / 06.2019 / PubMed / Full text
SATB2-Nanog axis links age-related intrinsic changes of mesenchymal stem cells from craniofacial bone. / 14.09.2016 / PubMed / Full text
Transplantation of osteoporotic bone marrow stromal cells rejuvenated by the overexpression of SATB2 prevents alveolar bone loss in ovariectomized rats. / 11.2016 / PubMed / Full text
Roles of SATB2 in site-specific stemness, autophagy and senescence of bone marrow mesenchymal stem cells. / 03.2015 / PubMed / Full text

SDC1

Olmesartan alleviates bleomycin-mediated vascular smooth muscle cell senescence via the miR-665/SDC1 axis. / 2020 / PubMed / Full text
Sulfated syndecan 1 is critical to preventing cellular senescence by modulating fibroblast growth factor receptor endocytosis. / 08.2020 / PubMed / Full text
Alterations in Corneal Sensory Nerves During Homeostasis, Aging, and After Injury in Mice Lacking the Heparan Sulfate Proteoglycan Syndecan-1. / 01.10.2017 / PubMed / Full text
Ionizing radiation-mediated premature senescence and paracrine interactions with cancer cells enhance the expression of syndecan 1 in human breast stromal fibroblasts: the role of TGF-β. / 08.2016 / PubMed / Full text

SF1

Prepubertal exposure to perfluorononanoic acid interferes with spermatogenesis and steroidogenesis in male mice. / 15.04.2019 / PubMed / Full text
Splicing factor 1 modulates dietary restriction and TORC1 pathway longevity in C. elegans. / 05.01.2017 / PubMed / Full text
The cerebellum ages slowly according to the epigenetic clock. / 05.2015 / PubMed / Full text
Loss of BMAL1 in ovarian steroidogenic cells results in implantation failure in female mice. / 30.09.2014 / PubMed / Full text

SFRP1

[Role and alterations of DNA methylation during the aging and cancer]. / 01.2018 / PubMed / Full text
Age-related increase in Wnt inhibitor causes a senescence-like phenotype in human cardiac stem cells. / 03.06.2017 / PubMed / Full text
Aging related methylation influences the gene expression of key control genes in colorectal cancer and adenoma. / 21.12.2016 / PubMed / Full text
The intrinsic stiffness of human trabecular meshwork cells increases with senescence. / 20.06.2015 / PubMed / Full text

SMN2

Age-dependent SMN expression in disease-relevant tissue and implications for SMA treatment. / 01.11.2019 / PubMed / Full text
Type 0 Spinal Muscular Atrophy: Further Delineation of Prenatal and Postnatal Features in 16 Patients. / 29.11.2016 / PubMed / Full text
Systemic peptide-mediated oligonucleotide therapy improves long-term survival in spinal muscular atrophy. / 27.09.2016 / PubMed / Full text
Motor neuron disease. SMN2 splicing modifiers improve motor function and longevity in mice with spinal muscular atrophy. / 08.08.2014 / PubMed / Full text

SP1

Identification of key genes and transcription factors in aging mesenchymal stem cells by DNA microarray data. / 15.04.2019 / PubMed / Full text
Downregulation of CITED2 contributes to TGFβ-mediated senescence of tendon-derived stem cells. / 04.2017 / PubMed / Full text
WNT1-induced Secreted Protein-1 (WISP1), a Novel Regulator of Bone Turnover and Wnt Signaling. / 29.05.2015 / PubMed / Full text
Homocysteine accelerates senescence of endothelial cells via DNA hypomethylation of human telomerase reverse transcriptase. / 01.2015 / PubMed / Full text

SPP1

Dehydroepiandrosterone enhances decidualization in women of advanced reproductive age. / 04.2018 / PubMed / Full text
Pathways of aging: comparative analysis of gene signatures in replicative senescence and stress induced premature senescence. / 28.12.2016 / PubMed / Full text
Autophagic homeostasis is required for the pluripotency of cancer stem cells. / 02.2017 / PubMed / Full text
Bone biology-related gingival transcriptome in ageing and periodontitis in non-human primates. / 05.2016 / PubMed / Full text

SPR

Regulation of lifespan by neural excitation and REST. / 10.2019 / PubMed / Full text
How many geriatricians should, at minimum, be staffing health regions in Australia? / 03.2018 / PubMed / Full text
Mutation of C. elegans demethylase spr-5 extends transgenerational longevity. / 02.2016 / PubMed / Full text
REST and stress resistance in ageing and Alzheimer's disease. / 27.03.2014 / PubMed / Full text

SPRY1

Sprouty1 Prevents Cellular Senescence Maintaining Proliferation and Differentiation Capacity of Human Adipose Stem/Progenitor Cells. / 13.11.2020 / PubMed / Full text
Mechanism of SPRY1 methylation regulating natural aging of skin epidermal cells. / 05.2020 / PubMed / Full text
MicroRNA-21 promotes glioma cell proliferation and inhibits senescence and apoptosis by targeting SPRY1 via the PTEN/PI3K/AKT signaling pathway. / 05.2018 / PubMed / Full text
Age-Associated Methylation Suppresses SPRY1, Leading to a Failure of Re-quiescence and Loss of the Reserve Stem Cell Pool in Elderly Muscle. / 10.11.2015 / PubMed / Full text

SRD5A2

Extract of Plumbago zeylanica enhances the growth of hair follicle dermal papilla cells with down-regulation of 5α-reductase type II. / 11.2020 / PubMed / Full text
Epidemiological and Mendelian Randomization Studies of Dihydrotestosterone and Estradiol and Leukocyte Telomere Length in Men. / 03.2016 / PubMed / Full text
DNA methyl transferase 1 reduces expression of SRD5A2 in the aging adult prostate. / 03.2015 / PubMed / Full text
Lessons learned about prostatic transformation from the age-related methylation of 5α-reductase type 2 gene. / 03.2015 / PubMed / Full text

STAR

Testicular gene expression of steroidogenesis-related factors in prepubertal, postpubertal, and aging dogs. / 01.03.2017 / PubMed / Full text
Role of the steroidogenic acute regulatory protein in health and disease. / 01.2016 / PubMed / Full text
Impact of acute geriatric care in elderly patients according to the Screening Tool of Older Persons' Prescriptions/Screening Tool to Alert doctors to Right Treatment criteria in northern France. / 02.2016 / PubMed / Full text
[Polypharmacy to the elderly prevails]. / 16.03.2015 / PubMed

STH

Regional variation in Ascaris lumbricoides and Trichuris trichiura infections by age cohort and sex: effects of market integration among the indigenous Shuar of Amazonian Ecuador. / 24.11.2016 / PubMed / Full text
Koolen-de Vries Syndrome: Clinical Report of an Adult and Literature Review. / 2016 / PubMed / Full text
Heritability and factors associated with number of harness race starts in the Spanish Trotter horse population. / 05.2017 / PubMed / Full text
Can chemotherapy alone eliminate the transmission of soil transmitted helminths? / 10.06.2014 / PubMed / Full text

TBC1D1

Therapeutic and preventive effects of exercise on cardiometabolic parameters in aging and obese rats. / 02.2019 / PubMed / Full text
Calorie restriction leads to greater Akt2 activity and glucose uptake by insulin-stimulated skeletal muscle from old rats. / 01.03.2016 / PubMed / Full text
Insulin Signaling and Glucose Uptake in the Soleus Muscle of 30-Month-Old Rats After Calorie Restriction With or Without Acute Exercise. / 03.2016 / PubMed / Full text
Effects of sex and age on chicken TBC1D1 gene mRNA expression. / 13.07.2015 / PubMed / Full text

TBP

Trinucleotide repeat expansion of TATA-binding protein gene associated with Parkinson's disease: A Thai multicenter study. / 07.2016 / PubMed / Full text
CALHM1 Deletion in Mice Affects Glossopharyngeal Taste Responses, Food Intake, Body Weight, and Life Span. / 07.2015 / PubMed / Full text
Deactivation of TBP contributes to SCA17 pathogenesis. / 20.12.2014 / PubMed / Full text
Age-dependent decrease in chaperone activity impairs MANF expression, leading to Purkinje cell degeneration in inducible SCA17 mice. / 22.01.2014 / PubMed / Full text

TET1

Age-related Changes in the Global DNA Methylation Profile of Oligodendrocyte Progenitor Cells Derived from Rat Spinal Cords. / 02.2019 / PubMed / Full text
Epigenetic Co-Deregulation of EZH2/TET1 is a Senescence-Countering, Actionable Vulnerability in Triple-Negative Breast Cancer. / 2019 / PubMed / Full text
DNA Hydroxymethylation Levels Are Altered in Blood Cells From Down Syndrome Persons Enrolled in the MARK-AGE Project. / 09.05.2018 / PubMed / Full text
Methylglyoxal induces endoplasmic reticulum stress and DNA demethylation in the Keap1 promoter of human lens epithelial cells and age-related cataracts. / 07.2014 / PubMed / Full text

TLR8

TLR8-Mediated Metabolic Control of Human Treg Function: A Mechanistic Target for Cancer Immunotherapy. / 08.01.2019 / PubMed / Full text
Controlling T cell senescence in the tumor microenvironment for tumor immunotherapy. / 03.2015 / PubMed / Full text
Cathelicidin related antimicrobial peptide, laminin, Toll-like receptors and chemokines levels in experimental hypersensitivity pneumonitis in mice. / 06.2015 / PubMed / Full text
TLR8 signaling enhances tumor immunity by preventing tumor-induced T-cell senescence. / 10.2014 / PubMed / Full text

TNNT3

Genome-wide associations and detection of potential candidate genes for direct genetic and maternal genetic effects influencing dairy cattle body weight at different ages. / 06.02.2019 / PubMed / Full text
Troponin T3 associates with DNA consensus sequence that overlaps with p53 binding motifs. / 15.07.2018 / PubMed / Full text
Effects of age and hindlimb immobilization and remobilization on fast troponin T precursor mRNA alternative splicing in rat gastrocnemius muscle. / 02.2016 / PubMed / Full text
Influence of ageing and essential amino acids on quantitative patterns of troponin T alternative splicing in human skeletal muscle. / 08.2015 / PubMed / Full text

TSC1

mTORC1 underlies age-related muscle fiber damage and loss by inducing oxidative stress and catabolism. / 06.2019 / PubMed / Full text
FTO is involved in Alzheimer's disease by targeting TSC1-mTOR-Tau signaling. / 25.03.2018 / PubMed / Full text
Postnatal reduction of tuberous sclerosis complex 1 expression in astrocytes and neurons causes seizures in an age-dependent manner. / 12.2017 / PubMed / Full text
Moderate lifelong overexpression of tuberous sclerosis complex 1 (TSC1) improves health and survival in mice. / 11.04.2017 / PubMed / Full text

TTL

Longitudinal Associations of Body Mass Index, Waist Circumference, and Waist-to-Hip Ratio with Biomarkers of Oxidative Stress in Older Adults: Results of a Large Cohort Study. / 2020 / PubMed / Full text
Evidence for the free radical/oxidative stress theory of ageing from the CHANCES consortium: a meta-analysis of individual participant data. / 15.12.2015 / PubMed / Full text
Role of the serotonin transporter gene locus in the response to SSRI treatment of major depressive disorder in late life. / 05.2015 / PubMed / Full text
Oxidative stress markers and all-cause mortality at older age: a population-based cohort study. / 04.2015 / PubMed / Full text

TXNRD1

The genetic component of human longevity: New insights from the analysis of pathway-based SNP-SNP interactions. / 06.2018 / PubMed / Full text
Mitochondrial thioredoxin reductase 2 is elevated in long-lived primate as well as rodent species and extends fly mean lifespan. / 08.2017 / PubMed / Full text
Antioxidants and Quality of Aging: Further Evidences for a Major Role of TXNRD1 Gene Variability on Physical Performance at Old Age. / 2015 / PubMed / Full text
Contribution of genetic polymorphisms on functional status at very old age: a gene-based analysis of 38 genes (311 SNPs) in the oxidative stress pathway. / 04.2014 / PubMed / Full text

VCAM1

Sunitinib facilitates metastatic breast cancer spreading by inducing endothelial cell senescence. / 29.09.2020 / PubMed / Full text
Aged blood impairs hippocampal neural precursor activity and activates microglia via brain endothelial cell VCAM1. / 06.2019 / PubMed / Full text
Cerebrospinal fluid biomarkers for Alzheimer's and vascular disease vary by age, gender, and APOE genotype in cognitively normal adults. / 03.07.2017 / PubMed / Full text
Endothelial Notch1 Activity Facilitates Metastasis. / 13.03.2017 / PubMed / Full text

VHL

Hypoxic response regulators RHY-1 and EGL-9/PHD promote longevity through a VHL-1-independent transcriptional response. / 12.2020 / PubMed / Full text
The Energy Maintenance Theory of Aging: Maintaining Energy Metabolism to Allow Longevity. / 08.2018 / PubMed / Full text
Shorter telomere length increases age-related tumor risks in von Hippel-Lindau disease patients. / 09.2017 / PubMed / Full text
Biological and clinical impact of hemangioblastoma-associated peritumoral cysts in von Hippel-Lindau disease. / 04.2016 / PubMed / Full text

WNT1

Plasma proteomic profile of age, health span, and all-cause mortality in older adults. / 11.2020 / PubMed / Full text
Aging Disrupts Muscle Stem Cell Function by Impairing Matricellular WISP1 Secretion from Fibro-Adipogenic Progenitors. / 07.03.2019 / PubMed / Full text
Wnt1 is an Lrp5-independent bone-anabolic Wnt ligand. / 07.11.2018 / PubMed / Full text
WNT1-induced Secreted Protein-1 (WISP1), a Novel Regulator of Bone Turnover and Wnt Signaling. / 29.05.2015 / PubMed / Full text

XPA

Analysis of somatic mutations identifies signs of selection during in vitro aging of primary dermal fibroblasts. / 12.2019 / PubMed / Full text
Proteomics and metabolomics identify molecular mechanisms of aging potentially predisposing for chronic lymphocytic leukemia. / 02.2018 / PubMed / Full text
Systematic analysis of DNA crosslink repair pathways during development and aging in Caenorhabditis elegans. / 19.09.2017 / PubMed / Full text
Defective mitophagy in XPA via PARP-1 hyperactivation and NAD( )/SIRT1 reduction. / 08.05.2014 / PubMed / Full text

XRCC4

The replicative senescent mesenchymal stem / stromal cells defect in DNA damage response and anti-oxidative capacity. / 2018 / PubMed / Full text
Impaired DNA double-strand break repair contributes to the age-associated rise of genomic instability in humans. / 01.11.2016 / PubMed / Full text
The impact of statins on biological characteristics of stem cells provides a novel explanation for their pleiotropic beneficial and adverse clinical effects. / 15.10.2015 / PubMed / Full text
Structural chromosome abnormalities, increased DNA strand breaks and DNA strand break repair deficiency in dermal fibroblasts from old female human donors. / 02.2015 / PubMed / Full text

ZEB1

MicroRNA-338-5p plays a tumor suppressor role in glioma through inhibition of the MAPK-signaling pathway by binding to FOXD1. / 12.2018 / PubMed / Full text
Ultraviolet A irradiation induces senescence in human dermal fibroblasts by down-regulating DNMT1 via ZEB1. / 16.02.2018 / PubMed / Full text
p16 induces senescence and inhibits EMT through microRNA-141/microRNA-146b-5p-dependent repression of AUF1. / 03.2017 / PubMed / Full text
The ZEB1 transcription factor acts in a negative feedback loop with miR200 downstream of Ras and Rb1 to regulate Bmi1 expression. / 14.02.2014 / PubMed / Full text

A2M

Age-Dependent Variation in Glycosylation Features of Alpha-2-Macroglobulin. / 12.2019 / PubMed / Full text
MMP2-A2M interaction increases ECM accumulation in aged rat kidney and its modulation by calorie restriction. / 19.01.2018 / PubMed / Full text
SPARCL1 Accelerates Symptom Onset in Alzheimer's Disease and Influences Brain Structure and Function During Aging. / 2018 / PubMed / Full text

AANAT

Pinealectomy or light exposure exacerbates biliary damage and liver fibrosis in cholestatic rats through decreased melatonin synthesis. / 01.06.2019 / PubMed / Full text
Morphofunctional and signaling molecules overlap of the pineal gland and thymus: role and significance in aging. / 15.03.2016 / PubMed / Full text
Comparison of arylalkylamine N-acetyltransferase and melatonin receptor type 1B immunoreactivity between young adult and aged canine spinal cord. / 2014 / PubMed / Full text

ABCB1

Paclitaxel-induced sensory peripheral neuropathy is associated with an ABCB1 single nucleotide polymorphism and older age in Japanese. / 06.2017 / PubMed / Full text
Relationship between mRNA expression levels of CYP3A4, CYP3A5 and SXR in peripheral mononuclear blood cells and aging in young kidney transplant recipients under tacrolimus treatment. / 2015 / PubMed / Full text
Vascular and extravascular distribution of the ATP-binding cassette transporters ABCB1 and ABCC1 in aged human brain and pituitary. / 11-12.2014 / PubMed / Full text

ACO1

Broad range metabolomics coupled with network analysis for explaining possible mechanisms of Er-Zhi-Wan in treating liver-kidney Yin deficiency syndrome of Traditional Chinese medicine. / 24.04.2019 / PubMed / Full text
Analysis of nodule senescence in pea (Pisum sativum L.) using laser microdissection, real-time PCR, and ACC immunolocalization. / 05.2017 / PubMed / Full text
The Persimmon 9-lipoxygenase Gene DkLOX3 Plays Positive Roles in Both Promoting Senescence and Enhancing Tolerance to Abiotic Stress. / 2015 / PubMed / Full text

AGT

SQSTM1/p62 and PPARGC1A/PGC-1alpha at the interface of autophagy and vascular senescence. / 06.2020 / PubMed / Full text
Towards frailty biomarkers: Candidates from genes and pathways regulated in aging and age-related diseases. / 11.2018 / PubMed / Full text
Lead-Related Genetic Loci, Cumulative Lead Exposure and Incident Coronary Heart Disease: The Normative Aging Study. / 2016 / PubMed / Full text

AGTR1

Lead-Related Genetic Loci, Cumulative Lead Exposure and Incident Coronary Heart Disease: The Normative Aging Study. / 2016 / PubMed / Full text
Association of gene variants of the renin-angiotensin system with accelerated hippocampal volume loss and cognitive decline in old age. / 01.11.2014 / PubMed / Full text
Impact of the AGTR1 A1166C polymorphism on subcortical hyperintensities and cognition in healthy older adults. / 2014 / PubMed / Full text

ALK

Catalog of Lung Cancer Gene Mutations Among Chinese Patients. / 2020 / PubMed / Full text
Age-related expression of TGF beta family receptors in human cumulus oophorus cells. / 09.2017 / PubMed / Full text
GBM-associated mutations and altered protein expression are more common in young patients. / 25.10.2016 / PubMed / Full text

APLP2

Analysis of Motor Function in Amyloid Precursor-Like Protein 2 Knockout Mice: The Effects of Ageing and Sex. / 06.2019 / PubMed / Full text
Amyloid Precursor-Like Protein 2 deletion-induced retinal synaptopathy related to congenital stationary night blindness: structural, functional and molecular characteristics. / 08.06.2016 / PubMed / Full text
Combined deletions of amyloid precursor protein and amyloid precursor-like protein 2 reveal different effects on mouse brain metal homeostasis. / 03.2014 / PubMed / Full text

APOA1

Effects of iron on the aggregation propensity of the N-terminal fibrillogenic polypeptide of human apolipoprotein A-I. / 08.2018 / PubMed / Full text
Age-related obesity and type 2 diabetes dysregulate neuronal associated genes and proteins in humans. / 06.10.2015 / PubMed / Full text
DNA methylation in the apolipoprotein-A1 gene is associated with episodic memory performance in healthy older individuals. / 2015 / PubMed / Full text

APOA5

Critical Role of SREBP-1c Large-VLDL Pathway in Environment-Induced Hypertriglyceridemia of Apo AV Deficiency. / 03.2019 / PubMed / Full text
Longitudinal interaction between APOA5 -1131T>C and overweight in the acceleration of age-related increase in arterial stiffness through the regulation of circulating triglycerides. / 02.2019 / PubMed / Full text
Genetic analysis of long-lived families reveals novel variants influencing high density-lipoprotein cholesterol. / 2014 / PubMed / Full text

APOC3

Positional Obstructive Sleep Apnea Syndrome in Elderly Patients. / 10.02.2020 / PubMed / Full text
No Association between Variation in Longevity Candidate Genes and Aging-related Phenotypes in Oldest-old Danes. / 06.2016 / PubMed / Full text
Nutritional habits, lifestyle, and genetic predisposition in cardiovascular and metabolic traits in Turkish population. / 06.2016 / PubMed / Full text

AQP5

Submandibular gland-specific inflammaging-induced hyposalivation in the male senescence-accelerated mouse prone -1 line (SAM-P1). / 08.2019 / PubMed / Full text
Investigation of age-related changes in the expression of aquaporin-1 and aquaporin-5 in the salivary glands of mice. / 09.2016 / PubMed / Full text
Combinations of differentiation markers distinguish subpopulations of alveolar epithelial cells in adult lung. / 15.01.2016 / PubMed / Full text

AREG

Targeting amphiregulin (AREG) derived from senescent stromal cells diminishes cancer resistance and averts programmed cell death 1 ligand (PD-L1)-mediated immunosuppression. / 12.2019 / PubMed / Full text
Regulatory T-cells regulate neonatal heart regeneration by potentiating cardiomyocyte proliferation in a paracrine manner. / 2019 / PubMed / Full text
Effects of aging on gene expression and mitochondrial DNA in the equine oocyte and follicle cells. / 07.2015 / PubMed / Full text

ARHGAP18

Stress-Induced Premature Senescence Promotes Proliferation by Activating the [i]SENEX[/i] and p16 /Retinoblastoma (Rb) Pathway in Diffuse Large B-Cell Lymphoma / 18.11.2019 / PubMed / Full text
Caveolae control the anti-inflammatory phenotype of senescent endothelial cells. / 02.2015 / PubMed / Full text
Transcript profile of cellular senescence-related genes in Fuchs endothelial corneal dystrophy. / 12.2014 / PubMed / Full text

ARID1A

Oncogenic mutations in histologically normal endometrium: the new normal? / 10.2019 / PubMed / Full text
ARID1A suppresses malignant transformation of human pancreatic cells via mediating senescence-associated miR-503/[[CDKN2A]] regulatory axis. / 18.11.2017 / PubMed / Full text
The Chromatin Remodeling Component Arid1a Is a Suppressor of Spontaneous Mammary Tumors in Mice. / 08.2016 / PubMed / Full text

ATG3

Estrogen Signaling Induces Mitochondrial Dysfunction-Associated Autophagy and Senescence in Breast Cancer Cells. / 01.04.2020 / PubMed / Full text
SIRT6 histone deacetylase functions as a potential oncogene in human melanoma. / 09.2017 / PubMed / Full text
Changes in macroautophagy, chaperone-mediated autophagy, and mitochondrial metabolism in murine skeletal and cardiac muscle during aging. / 26.02.2017 / PubMed / Full text

BAK1

Developmental Attenuation of Neuronal Apoptosis by Neural-Specific Splicing of Bak1 Microexon. / 23.09.2020 / PubMed / Full text
SIRT6 histone deacetylase functions as a potential oncogene in human melanoma. / 09.2017 / PubMed / Full text
The dominant negative ARM domain uncovers multiple functions of PUB13 in Arabidopsis immunity, flowering, and senescence. / 06.2015 / PubMed / Full text

BATF

LncRNA-ES3 inhibition by Bhlhe40 is involved in high glucose-induced calcification/senescence of vascular smooth muscle cells. / 08.2020 / PubMed / Full text
Transcription factor networks in aged naïve CD4 T cells bias lineage differentiation. / 08.2019 / PubMed / Full text
Transcriptomic analysis of human IL-7 receptor alpha and effector memory CD8 T cells reveals an age-associated signature linked to influenza vaccine response in older adults. / 08.2019 / PubMed / Full text

BECN1

Calpain-dependent Beclin1 cleavage stimulates senescence-associated cell death in HT22 hippocampal cells under the oxidative stress conditions. / 14.05.2019 / PubMed / Full text
Autophagy regulates the degeneration of the auditory cortex through the AMPK-mTOR-ULK1 signaling pathway. / 04.2018 / PubMed / Full text
Metabolomic analyses reveal that anti-aging metabolites are depleted by palmitate but increased by oleate in vivo. / 03.08.2015 / PubMed / Full text

BGN

Alterations of local functional connectivity in lifespan: A resting-state fMRI study. / 07.2020 / PubMed / Full text
Exploring variability in basal ganglia connectivity with functional MRI in healthy aging. / 12.2018 / PubMed / Full text
Age-dependent changes in inflammation and extracellular matrix in bovine oviduct epithelial cells during the post-ovulatory phase. / 09.2016 / PubMed / Full text

BMP15

Antioxidant hesperetin improves the quality of porcine oocytes during aging in vitro. / 01.2019 / PubMed / Full text
Observation of the influences of diosgenin on aging ovarian reserve and function in a mouse model. / 18.10.2017 / PubMed / Full text
Effects of aging on gene expression and mitochondrial DNA in the equine oocyte and follicle cells. / 07.2015 / PubMed / Full text

BMP6

Noggin rescues age-related stem cell loss in the brain of senescent mice with neurodegenerative pathology. / 06.11.2018 / PubMed / Full text
Cyp1b1 deletion and retinol deficiency coordinately suppress mouse liver lipogenic genes and hepcidin expression during post-natal development. / 15.10.2017 / PubMed / Full text
Age-dependent shifts in renal response to injury relate to altered BMP6/CTGF expression and signaling. / 01.11.2016 / PubMed / Full text

BMP7

Downregulation of miR-542-3p promotes osteogenic transition of vascular smooth muscle cells in the aging rat by targeting BMP7. / 11.12.2019 / PubMed / Full text
TGF-beta receptor mediated telomerase inhibition, telomere shortening and breast cancer cell senescence. / 01.2017 / PubMed / Full text
Effects of Usag-1 and Bmp7 deficiencies on murine tooth morphogenesis. / 13.05.2016 / PubMed / Full text

BMPR2

Centenarians Overexpress Pluripotency-Related Genes. / 16.08.2019 / PubMed / Full text
Age-related expression of TGF beta family receptors in human cumulus oophorus cells. / 09.2017 / PubMed / Full text
Selective enhancement of endothelial BMPR-II with BMP9 reverses pulmonary arterial hypertension. / 07.2015 / PubMed / Full text

BSN

Nurses' perspectives: hospitalized older patients and end-of-life decision-making. / 03.2016 / PubMed / Full text
Buddhist social networks and health in old age: A study in central Thailand. / 11.2015 / PubMed / Full text
Retaining the wisdom: Academic nurse leaders' reflections on extending the working life of aging nurse faculty. / 01-02.2014 / PubMed / Full text

CAPS

The Effect of Aging on the Ventilatory Response to Wearing a Chemical, Biological, Radiological, and Nuclear Hood Respirator at Rest and During Mild Exercise. / 01.2017 / PubMed / Full text
[Human bioaging acceleration as Chernobyl radiation consequence]. / 11-12.2013 / PubMed
[Adaptation of self-image level and defense mechanisms in elderly patients with complicated stoma]. / 11-12.2014 / PubMed / Full text

CARM1

CARM1 regulates senescence during airway epithelial cell injury in COPD pathogenesis. / 01.11.2019 / PubMed / Full text
Nuclear AMPK regulated CARM1 stabilization impacts autophagy in aged heart. / 29.04.2017 / PubMed / Full text
Coactivator-Associated Arginine Methyltransferase-1 Function in Alveolar Epithelial Senescence and Elastase-Induced Emphysema Susceptibility. / 12.2015 / PubMed / Full text

CASS4

Genetic Biomarkers on Age-Related Cognitive Decline. / 2017 / PubMed / Full text
Association and interaction effects of Alzheimer's disease-associated genes and lifestyle on cognitive aging in older adults in a Taiwanese population. / 11.04.2017 / PubMed / Full text
Gene-based aggregate SNP associations between candidate AD genes and cognitive decline. / 04.2016 / PubMed / Full text

CCN3

CCN3 Signaling Is Differently Regulated in Placental Diseases Preeclampsia and Abnormally Invasive Placenta. / 2020 / PubMed / Full text
CCN3 (NOV) Drives Degradative Changes in Aging Articular Cartilage. / 13.10.2020 / PubMed / Full text
CCN1 (CYR61) and CCN3 (NOV) signaling drives human trophoblast cells into senescence and stimulates migration properties. / 03.03.2016 / PubMed / Full text

CCNA2

Hypoxia Upregulates Mitotic Cyclins Which Contribute to the Multipotency of Human Mesenchymal Stem Cells by Expanding Proliferation Lifespan. / 31.03.2018 / PubMed / Full text
Cyclin A2 promotes DNA repair in the brain during both development and aging. / 07.2016 / PubMed / Full text
PIM-1 modulates cellular senescence and links IL-6 signaling to heterochromatin formation. / 10.2014 / PubMed / Full text

CCNB1

Antioxidant hesperetin improves the quality of porcine oocytes during aging in vitro. / 01.2019 / PubMed / Full text
Effect of CCNB1 silencing on cell cycle, senescence, and apoptosis through the p53 signaling pathway in pancreatic cancer. / 01.2018 / PubMed / Full text
Hypoxia Upregulates Mitotic Cyclins Which Contribute to the Multipotency of Human Mesenchymal Stem Cells by Expanding Proliferation Lifespan. / 31.03.2018 / PubMed / Full text

CCR3

Low Molecular Weight Hyaluronan Induces an Inflammatory Response in Ovarian Stromal Cells and Impairs Gamete Development In Vitro. / 04.02.2020 / PubMed / Full text
Early life allergen and air pollutant exposures alter longitudinal blood immune profiles in infant rhesus monkeys. / 01.08.2017 / PubMed / Full text
An emerging role for eotaxins in neurodegenerative disease. / 04.2018 / PubMed / Full text

CCR4

mTOR regulates the expression of DNA damage response enzymes in long-lived Snell dwarf, GHRKO, and PAPPA-KO mice. / 02.2017 / PubMed / Full text
Circulating T helper and T regulatory subsets in untreated early rheumatoid arthritis and healthy control subjects. / 10.2016 / PubMed / Full text
CCR4 Regulatory T Cells Accumulate in the Very Elderly and Correlate With Superior 8-Year Survival. / 08.2015 / PubMed / Full text

CD200

Age exacerbates surgery-induced cognitive impairment and neuroinflammation in Sprague-Dawley rats: the role of IL-4. / 15.06.2017 / PubMed / Full text
Prior stressor exposure delays the recovery of surgery-induced cognitive impairment and prolongs neuroinflammation in aged rats. / 01.10.2016 / PubMed / Full text
Brain innate immunity in the regulation of neuroinflammation: therapeutic strategies by modulating CD200-CD200R interaction involve the cannabinoid system. / 2014 / PubMed / Full text

CD81

Ovarian aging increases small extracellular vesicle CD81 release in human follicular fluid and influences miRNA profiles. / 17.06.2020 / PubMed / Full text
Older Adults with Physical Frailty and Sarcopenia Show Increased Levels of Circulating Small Extracellular Vesicles with a Specific Mitochondrial Signature. / 15.04.2020 / PubMed / Full text
Increased production of functional small extracellular vesicles in senescent endothelial cells. / 04.2020 / PubMed / Full text

CEL

Nanocarrier-Mediated Chemo-Immunotherapy Arrested Cancer Progression and Induced Tumor Dormancy in Desmoplastic Melanoma. / 28.08.2018 / PubMed / Full text
An advanced glycation endproduct (AGE)-rich diet promotes accumulation of AGEs in Achilles tendon. / 03.2017 / PubMed / Full text
Biological Effects Induced by Specific Advanced Glycation End Products in the Reconstructed Skin Model of Aging. / 2015 / PubMed / Full text

CFB

The expression of C1 inhibitor (C1INH) in macrophages is upregulated by retinal pigment epithelial cells - implication in subretinal immune privilege in the aging eye. / 13.06.2018 / PubMed / Full text
Extended Multiplexing of Tandem Mass Tags (TMT) Labeling Reveals Age and High Fat Diet Specific Proteome Changes in Mouse Epididymal Adipose Tissue. / 05.2017 / PubMed / Full text
Genetic factors associated with the development of age-related macular degeneration. / 2016 / PubMed / Full text

CHAT

Satisfaction and Technology Evaluation of a Telehealth Robotic Program to Optimize Healthy Independent Living for Older Adults. / 11.2018 / PubMed / Full text
Reliability of the Language ENvironment Analysis system (LENA™) in European French. / 09.2016 / PubMed / Full text
Age-related gene expression analysis in enteric ganglia of human colon after laser microdissection. / 2014 / PubMed / Full text

CISD2

CISD2 Attenuates Inflammation and Regulates Microglia Polarization in EOC Microglial Cells-As a Potential Therapeutic Target for Neurodegenerative Dementia. / 2020 / PubMed / Full text
Protective Effects of CISD2 and Influence of Curcumin on CISD2 Expression in Aged Animals and Inflammatory Cell Model. / 25.03.2019 / PubMed / Full text
Cisd2 mediates lifespan: is there an interconnection among Ca²⁺ homeostasis, autophagy, and lifespan? / 09.2014 / PubMed / Full text

COL1A2

Sirtuin 7 is decreased in pulmonary fibrosis and regulates the fibrotic phenotype of lung fibroblasts. / 01.06.2017 / PubMed / Full text
Genetic variants associated with skin aging in the Chinese Han population. / 04.2017 / PubMed / Full text
Effects of aging and uninephrectomy on renal changes in Tsukuba hypertensive mice. / 05.2013 / PubMed / Full text

COL3A1

Different expression of Defensin-B gene in the endometrium of mares of different age during the breeding season. / 21.12.2019 / PubMed / Full text
Reductive Stress Selectively Disrupts Collagen Homeostasis and Modifies Growth Factor-independent Signaling Through the MAPK/Akt Pathway in Human Dermal Fibroblasts. / 06.2019 / PubMed / Full text
Sirtuin 7 is decreased in pulmonary fibrosis and regulates the fibrotic phenotype of lung fibroblasts. / 01.06.2017 / PubMed / Full text

COL6A1

Epigenome-wide exploratory study of monozygotic twins suggests differentially methylated regions to associate with hand grip strength. / 10.2019 / PubMed / Full text
Genome-wide DNA methylation profiles reveal novel candidate genes associated with meat quality at different age stages in hens. / 05.04.2017 / PubMed / Full text
Bethlem myopathy: long-term follow-up identifies COL6 mutations predicting severe clinical evolution. / 12.2015 / PubMed / Full text

CPT1C

Carnitine palmitoyltransferase 1C reverses cellular senescence of MRC-5 fibroblasts via regulating lipid accumulation and mitochondrial function. / 02.2021 / PubMed / Full text
Carnitine palmitoyltransferase 1C contributes to progressive cellular senescence. / 14.04.2020 / PubMed / Full text
Effects of carnitine palmitoyltransferases on cancer cellular senescence. / 02.2019 / PubMed / Full text

CRY2

Is the aging human ovary still ticking?: Expression of clock-genes in luteinized granulosa cells of young and older women. / 21.11.2018 / PubMed / Full text
Role of Aging and Hippocampus in Time-Place Learning: Link to Episodic-Like Memory? / 2015 / PubMed / Full text
Association of osteoporosis with genetic variants of circadian genes in Chinese geriatrics. / 04.2016 / PubMed / Full text

CTC1

CTC1-STN1 coordinates G- and C-strand synthesis to regulate telomere length. / 08.2018 / PubMed / Full text
Stimulation of cell proliferation by glutathione monoethyl ester in aged bone marrow stromal cells is associated with the assistance of TERT gene expression and telomerase activity. / 08.2016 / PubMed / Full text
Genome wide association and linkage analyses identified three loci-4q25, 17q23.2, and 10q11.21-associated with variation in leukocyte telomere length: the Long Life Family Study. / 2013 / PubMed / Full text

CTH

Anterior Cingulate Structure and Perfusion is Associated with Cerebrospinal Fluid Tau among Cognitively Normal Older Adult APOEɛ4 Carriers. / 2020 / PubMed / Full text
Curious CXR. / 07.2019 / PubMed / Full text
Mechanochemical Catalytic Transfer Hydrogenation of Aromatic Nitro Derivatives. / 30.11.2018 / PubMed / Full text

CTLA4

Horticultural Therapy Reduces Biomarkers of Immunosenescence and Inflammaging in Community-Dwelling Older Adults: A Feasibility Pilot Randomized Controlled Trial. / 18.10.2020 / PubMed / Full text
[Efficacy and toxicity of immune checkpoint inhibitors in elderly patients - 5th edition of the congress of pharmacology of anticancer drugs]. / 12.2018 / PubMed / Full text
Circulating T helper and T regulatory subsets in untreated early rheumatoid arthritis and healthy control subjects. / 10.2016 / PubMed / Full text

CXCL11

Endothelial cells under therapy-induced senescence secrete CXCL11, which increases aggressiveness of breast cancer cells. / 10.10.2020 / PubMed / Full text
Prebiotic supplementation in frail older people affects specific gut microbiota taxa but not global diversity. / 13.03.2019 / PubMed / Full text
[Signal molecules of endometrium: gerontological and general pathhological aspects]. / 2015 / PubMed

CXCL13

RNA-seq data from C-X-C chemokine receptor type 5 (CXCR5) gene knockout aged mice with retinal degeneration phenotype. / 08.2020 / PubMed / Full text
Structural and functional changes to lymph nodes in ageing mice. / 06.2017 / PubMed / Full text
Artery Tertiary Lymphoid Organs: Powerhouses of Atherosclerosis Immunity. / 2016 / PubMed / Full text

CXCL16

CXCR6 Inhibits Hepatocarcinogenesis by Promoting Natural Killer T- and CD4 T-Cell-Dependent Control of Senescence. / 05.2019 / PubMed / Full text
Estrogen receptor β, a regulator of androgen receptor signaling in the mouse ventral prostate. / 09.05.2017 / PubMed / Full text
Age-related alterations in blood and colonic dendritic cell properties. / 15.03.2016 / PubMed / Full text

CXCL5

Hassall's corpuscles with cellular-senescence features maintain IFNα production through neutrophils and pDC activation in the thymus. / 05.03.2019 / PubMed / Full text
Urine Cytokine and Chemokine Levels Predict Urinary Tract Infection Severity Independent of Uropathogen, Urine Bacterial Burden, Host Genetics, and Host Age. / 09.2018 / PubMed / Full text
Simultaneous time course analysis of multiple markers based on DNA microarray in incised wound in skeletal muscle for wound aging. / 09.2016 / PubMed / Full text

CXCR5

Altered marginal zone and innate-like B cells in aged senescence-accelerated SAMP8 mice with defective IgG1 responses. / 17.08.2017 / PubMed / Full text
Circulating T helper and T regulatory subsets in untreated early rheumatoid arthritis and healthy control subjects. / 10.2016 / PubMed / Full text
Trafficking phenotype and production of granzyme B by double negative B cells (IgG( )IgD(-)CD27(-)) in the elderly. / 06.2014 / PubMed / Full text

CYLD

Premature aging and cancer development in transgenic mice lacking functional CYLD. / 10.01.2019 / PubMed / Full text
Pathophysiological significance of cylindromatosis in the vascular endothelium and macrophages for the initiation of age-related atherogenesis. / 22.01.2019 / PubMed / Full text
Elevated A20 contributes to age-dependent macrophage dysfunction in the lungs. / 06.2014 / PubMed / Full text

CYP19A1

Vitamin D3 mediated regulation of steroidogenesis mitigates testicular activity in an aged rat model. / 06.2019 / PubMed / Full text
Epidemiological and Mendelian Randomization Studies of Dihydrotestosterone and Estradiol and Leukocyte Telomere Length in Men. / 03.2016 / PubMed / Full text
Compensatory Increase in Ovarian Aromatase in Older Regularly Cycling Women. / 09.2015 / PubMed / Full text

CYP1A1

Genome-wide scan identified genetic variants associated with skin aging in a Chinese female population. / 10.2019 / PubMed / Full text
Furanoflavones pongapin and lanceolatin B blocks the cell cycle and induce senescence in CYP1A1-overexpressing breast cancer cells. / 15.12.2018 / PubMed / Full text
Cell type-specific expression and localization of cytochrome P450 isoforms in tridimensional aggregating rat brain cell cultures. / 25.12.2015 / PubMed / Full text

CYP1B1

Bisphenol A induces DSB-ATM-p53 signaling leading to cell cycle arrest, senescence, autophagy, stress response, and estrogen release in human fetal lung fibroblasts. / 04.2018 / PubMed / Full text
Target disruption of ribosomal protein pNO40 accelerates aging and impairs osteogenic differentiation of mesenchymal stem cells. / 22.01.2016 / PubMed / Full text
Expression of genes for AhR and Nrf2 signal pathways in the retina of OXYS rats during the development of retinopathy and melatonin-induced changes in this process. / 08.2014 / PubMed / Full text

CYP27B1

Decreased Serum 25-Hydroxyvitamin D in Aging Male Mice Is Associated With Reduced Hepatic Cyp2r1 Abundance. / 01.08.2018 / PubMed / Full text
Oleanolic Acid Exerts Osteoprotective Effects and Modulates Vitamin D Metabolism. / 22.02.2018 / PubMed / Full text
Environmental and genetic determinants of vitamin D status among older adults in London, UK. / 11.2016 / PubMed / Full text

CYP2C9

Pediatric Cytochrome P450 Activity Alterations in Nonalcoholic Steatohepatitis. / 12.2017 / PubMed / Full text
Determination of Human Hepatic CYP2C8 and CYP1A2 Age-Dependent Expression to Support Human Health Risk Assessment for Early Ages. / 05.2017 / PubMed / Full text
Genotype-based dosage of acenocoumarol in highly-sensitive geriatric patients. / 03.2015 / PubMed / Full text

CYP2J2

The effects of endothelium-specific CYP2J2 overexpression on the attenuation of retinal ganglion cell apoptosis in a glaucoma rat model. / 10.2019 / PubMed / Full text
Regional vulnerability to lipoxidative damage and inflammation in normal human brain aging. / 01.10.2018 / PubMed / Full text
Endothelium-specific CYP2J2 overexpression attenuates age-related insulin resistance. / 04.2018 / PubMed / Full text

CYP2R1

Decreased Serum 25-Hydroxyvitamin D in Aging Male Mice Is Associated With Reduced Hepatic Cyp2r1 Abundance. / 01.08.2018 / PubMed / Full text
Environmental and genetic determinants of vitamin D status among older adults in London, UK. / 11.2016 / PubMed / Full text
Late-onset hypogonadism: beyond testosterone. / 03-04.2015 / PubMed / Full text

CYP7A1

Age-associated changes of cytochrome P450 and related phase-2 gene/proteins in livers of rats. / 2019 / PubMed / Full text
Combined toxicity of endosulfan and phenanthrene mixtures and induced molecular changes in adult Zebrafish (Danio rerio). / 03.2018 / PubMed / Full text
Synergic hypocholesterolaemic effect of n-3 PUFA and oestrogen by modulation of hepatic cholesterol metabolism in female rats. / 14.12.2015 / PubMed / Full text

DAP

Examining changes in the equity of physician distribution in Japan: a specialty-specific longitudinal study. / 08.01.2018 / PubMed / Full text
Evaluation of organ and effective doses during paediatric barium meal examinations using PCXMC 2.0 Monte Carlo code. / 02.2015 / PubMed / Full text
Relationship between identity and attitude toward death in Japanese senior citizens. / 2014 / PubMed / Full text

DBH

ADHD risk genes involved in dopamine signaling and metabolism are associated with reduced estimated life expectancy at young adult follow-up in hyperactive and control children. / 04.2019 / PubMed / Full text
Age-related changes in immunoreactivity for dopamine β-hydroxylase in carotid body glomus cells in spontaneously hypertensive rats. / 07.2017 / PubMed / Full text
Healthy aging increases the cognitive effects of two genes that influence extracellular dopamine. / 06.2014 / PubMed / Full text

DDC

N-Acetyl Cysteine Attenuates the Sarcopenia and Muscle Apoptosis Induced by Chronic Liver Disease. / 2019 / PubMed / Full text
Aging-Related Expression of Twinfilin-1 Regulates Cholangiocyte Biological Response to Injury. / 09.2019 / PubMed / Full text
Life History of Parthenolecanium spp. (Hemiptera: Coccidae) in Urban Landscapes of the Southeastern United States. / 01.08.2017 / PubMed / Full text

DDO

New insights on the influence of free d-aspartate metabolism in the mammalian brain during prenatal and postnatal life. / 10.2020 / PubMed / Full text
Free d-aspartate triggers NMDA receptor-dependent cell death in primary cortical neurons and perturbs JNK activation, Tau phosphorylation, and protein SUMOylation in the cerebral cortex of mice lacking d-aspartate oxidase activity. / 07.2019 / PubMed / Full text
Secreted d-aspartate oxidase functions in C. elegans reproduction and development. / 01.2019 / PubMed / Full text

DDX58

Transcriptome analysis reveals immune-related gene expression changes with age in giant panda ([i]Ailuropoda melanoleuca[/i]) blood. / 14.01.2019 / PubMed / Full text
Age-associated mRNA expression changes in bovine endometrial cells in vitro. / 14.08.2017 / PubMed / Full text
Progression of pathology in PINK1-deficient mouse brain from splicing via ubiquitination, ER stress, and mitophagy changes to neuroinflammation. / 02.08.2017 / PubMed / Full text

DGAT1

Ghrelin deletion protects against age-associated hepatic steatosis by downregulating the C/EBPα-p300/DGAT1 pathway. / 02.2018 / PubMed / Full text
Genome-wide association study for lactation persistency, female fertility, longevity, and lifetime profit index traits in Holstein dairy cattle. / 02.2017 / PubMed / Full text
Cardiomyocyte-specific loss of diacylglycerol acyltransferase 1 (DGAT1) reproduces the abnormalities in lipids found in severe heart failure. / 24.10.2014 / PubMed / Full text

DISC1

Age-Related Changes in Topological Degradation of White Matter Networks and Gene Expression in Chronic Schizophrenia. / 11.2017 / PubMed / Full text
Disruption to schizophrenia-associated gene Fez1 in the hippocampus of HDAC11 knockout mice. / 19.09.2017 / PubMed / Full text
PAKs inhibitors ameliorate schizophrenia-associated dendritic spine deterioration in vitro and in vivo during late adolescence. / 29.04.2014 / PubMed / Full text

DKC1

Successful liver transplantation in short telomere syndromes without bone marrow failure due to DKC1 mutation. / 05.2020 / PubMed / Full text
Acute telomerase components depletion triggers oxidative stress as an early event previous to telomeric shortening. / 04.2018 / PubMed / Full text
Cinnamaldehyde and eugenol change the expression folds of AKT1 and DKC1 genes and decrease the telomere length of human adipose-derived stem cells (hASCs): An experimental and in silico study. / 03.2017 / PubMed / Full text

DMP1

Cx43 overexpression in osteocytes prevents osteocyte apoptosis and preserves cortical bone quality in aging mice. / 07.2018 / PubMed / Full text
[i]Dmp1[/i] Null Mice Develop a Unique Osteoarthritis-like Phenotype. / 2016 / PubMed / Full text
Decline in calcitonin receptor expression in osteocytes with age. / 05.2014 / PubMed / Full text

DPT

Influence of season, age and management on scrotal thermal profile in Murrah bulls using scrotal infrared digital thermography. / 12.2017 / PubMed / Full text
Effects of an integrated geriatric group balance class within an entry-level Doctorate of Physical Therapy program on students' perceptions of geriatrics and geriatric education in the United States. / 2016 / PubMed / Full text
Auditory Temporal Processing Deficits in Chronic Stroke: A Comparison of Brain Damage Lateralization Effect. / 06.2016 / PubMed / Full text

DRD3

Image-guided phenotyping of ovariectomized mice: altered functional connectivity, cognition, myelination, and dopaminergic functionality. / 02.2019 / PubMed / Full text
Dopamine-Related Genotypes and Physical Activity Change During an Intervention: The Lifestyle Interventions and Independence for Elders Study. / 07.2018 / PubMed / Full text
Dopamine Receptor Genes Modulate Associative Memory in Old Age. / 02.2017 / PubMed / Full text

DST

Ancestral germen/soma distinction in microbes: Expanding the disposable soma theory of aging to all unicellular lineages. / 07.2020 / PubMed / Full text
Diet Quality Is Associated With Mortality in Adults Aged 80 Years and Older: A Prospective Study. / 10.2019 / PubMed / Full text
The associations between diet quality, Body Mass Index (BMI) and Health and Activity Limitation Index (HALex) in the Geisinger Rural Aging Study (GRAS). / 2014 / PubMed / Full text

E2F3

Time-course transcriptome analysis of medullary thymic epithelial cells in the early phase of thymic involution. / 07.2018 / PubMed / Full text
miR-34a promotes fibrosis in aged lungs by inducing alveolarepithelial dysfunctions. / 01.03.2017 / PubMed / Full text
Global transcriptional profiling reveals distinct functions of thymic stromal subsets and age-related changes during thymic involution. / 09.10.2014 / PubMed / Full text

EHF

Extended high frequency hearing and speech perception implications in adults and children. / 11.2020 / PubMed / Full text
[INFLUENCE OF MILLIMETER-WAVE ELECTROMAGNETIC EMISSION ON NITRIC OXIDE SYNTHESIS DURING VESSEL ENDOTHELIUM AGING IN VITRO]. / 2015 / PubMed
[Molecular mechanisms of combined extremely radiofrequency and infrared therapy in various age patients with chronic parodontitis]. / 2014 / PubMed

ELF3

High Ambient Temperature Accelerates Leaf Senescence via PHYTOCHROME-INTERACTING FACTOR 4 and 5 in [i]Arabidopsis[/i]. / 31.07.2020 / PubMed / Full text
Mutation of Rice Early Flowering3.1 (OsELF3.1) delays leaf senescence in rice. / 09.2016 / PubMed / Full text
Phytochrome-interacting transcription factors PIF4 and PIF5 induce leaf senescence in Arabidopsis. / 14.08.2014 / PubMed / Full text

EP300

Identification of key genes and transcription factors in aging mesenchymal stem cells by DNA microarray data. / 15.04.2019 / PubMed / Full text
Aspirin-another caloric-restriction mimetic. / 2018 / PubMed / Full text
Aspirin Recapitulates Features of Caloric Restriction. / 27.02.2018 / PubMed / Full text

EPOR

Age-associated expression of erythropoietin and its receptor in rat spiral ganglion neurons and its association with neuronal apoptosis and hearing alterations. / 01.2017 / PubMed / Full text
Erythropoietin Does Not Enhance Skeletal Muscle Protein Synthesis Following Exercise in Young and Older Adults. / 2016 / PubMed / Full text
Oxidative stress induces the decline of brain EPO expression in aging rats. / 10.2016 / PubMed / Full text

ETS1

The transcription factor ETS1 promotes apoptosis resistance of senescent cholangiocytes by epigenetically up-regulating the apoptosis suppressor BCL2L1. / 06.12.2019 / PubMed / Full text
G protein-coupled receptor kinase 4-induced cellular senescence and its senescence-associated gene expression profiling. / 15.11.2017 / PubMed / Full text
ETS Proto-oncogene 1 Transcriptionally Up-regulates the Cholangiocyte Senescence-associated Protein Cyclin-dependent Kinase Inhibitor 2A. / 24.03.2017 / PubMed / Full text

F7

The Pattern of Mu Rhythm Modulation During Emotional Destination Memory: Comparison Between Mild Cognitive Impairment Patients and Healthy Controls. / 2019 / PubMed / Full text
High levels of incidental physical activity are positively associated with cognition and EEG activity in aging. / 2018 / PubMed / Full text
[Clinical and genetic characteristics of long-livers in Moscow region]. / 2013 / PubMed

F9

Hypermaintenance and hypofunction of aged spermatogonia: insight from age-related increase of Plzf expression. / 30.06.2015 / PubMed / Full text
eHealth literacy and Web 2.0 health information seeking behaviors among baby boomers and older adults. / 17.03.2015 / PubMed / Full text
Effects of aging on gene expression and mitochondrial DNA in the equine oocyte and follicle cells. / 07.2015 / PubMed / Full text

FABP3

FABP3-mediated membrane lipid saturation alters fluidity and induces ER stress in skeletal muscle with aging. / 09.11.2020 / PubMed / Full text
Autophagy receptor OPTN (optineurin) regulates mesenchymal stem cell fate and bone-fat balance during aging by clearing FABP3. / 04.11.2020 / PubMed / Full text
Myokines as biomarkers of frailty and cardiovascular disease risk in females. / 05.2020 / PubMed / Full text

FAH

Oxaloacetate decarboxylase FAHD1 - a new regulator of mitochondrial function and senescence. / 01.2019 / PubMed / Full text
Depletion of oxaloacetate decarboxylase FAHD1 inhibits mitochondrial electron transport and induces cellular senescence in human endothelial cells. / 06.2017 / PubMed / Full text
Associations between toe grip strength and hallux valgus, toe curl ability, and foot arch height in Japanese adults aged 20 to 79 years: a cross-sectional study. / 2015 / PubMed / Full text

FERMT2

Extended Multiplexing of Tandem Mass Tags (TMT) Labeling Reveals Age and High Fat Diet Specific Proteome Changes in Mouse Epididymal Adipose Tissue. / 05.2017 / PubMed / Full text
Association and interaction effects of Alzheimer's disease-associated genes and lifestyle on cognitive aging in older adults in a Taiwanese population. / 11.04.2017 / PubMed / Full text
Gene-based aggregate SNP associations between candidate AD genes and cognitive decline. / 04.2016 / PubMed / Full text

FOXP1

GATA6 regulates aging of human mesenchymal stem/stromal cells. / 30.11.2020 / PubMed / Full text
Identification of the neurotransmitter profile of AmFoxP expressing neurons in the honeybee brain using double-label in situ hybridization. / 06.11.2018 / PubMed / Full text
Downregulation of FOXP1 correlates with tendon stem/progenitor cells aging. / 26.09.2018 / PubMed / Full text

FUNDC1

Mitochondria organize the cellular proteostatic response and promote cellular senescence. / 15.03.2019 / PubMed / Full text
A mitochondrial FUNDC1/HSC70 interaction organizes the proteostatic stress response at the risk of cell morbidity. / 01.02.2019 / PubMed / Full text
In Brief: Mitophagy: mechanisms and role in human disease. / 11.2016 / PubMed / Full text

FYN

An inhibitor role of Nrf2 in the regulation of myocardial senescence and dysfunction after myocardial infarction. / 15.10.2020 / PubMed / Full text
Identification of key genes and transcription factors in aging mesenchymal stem cells by DNA microarray data. / 15.04.2019 / PubMed / Full text
Cell fate regulation by reticulon-4 in human prostate cancers. / 07.2019 / PubMed / Full text

GALC

Analysis of age-related changes in psychosine metabolism in the human brain. / 2018 / PubMed / Full text
Age and gender-specific reference intervals for lysosomal enzymes in dried blood spot samples: A study in Indian population. / 10.2017 / PubMed / Full text
Long-term Improvements in Lifespan and Pathology in CNS and PNS After BMT Plus One Intravenous Injection of AAVrh10-GALC in Twitcher Mice. / 11.2015 / PubMed / Full text

GATA3

An imbalance in the T-helper phenotypes displayed by senescent CD4 CD28 T cells is associated with erosive arthritis (rhupus syndrome) in systemic lupus erythematosus. / 11.2018 / PubMed / Full text
Expression of Luminal Progenitor Marker CD117 in the Human Breast Gland. / 12.2018 / PubMed / Full text
In Vivo Interplay between p27 , GATA3, ATOH1, and POU4F3 Converts Non-sensory Cells to Hair Cells in Adult Mice. / 11.04.2017 / PubMed / Full text

GATA6

GATA Regulation and Function During the Ovarian Life Cycle. / 2018 / PubMed / Full text
Decline in cellular function of aged mouse c-kit cardiac progenitor cells. / 01.10.2017 / PubMed / Full text
Autophagic homeostasis is required for the pluripotency of cancer stem cells. / 02.2017 / PubMed / Full text

GCK

The Impact of Biomarker Screening and Cascade Genetic Testing on the Cost-Effectiveness of MODY Genetic Testing. / 12.2019 / PubMed / Full text
Developmental changes in hepatic glucose metabolism in a newborn piglet model: A comparative analysis for suckling period and early weaning period. / 19.02.2016 / PubMed / Full text
Genome-wide association study identifies common loci influencing circulating glycated hemoglobin (HbA1c) levels in non-diabetic subjects: the Long Life Family Study (LLFS). / 04.2014 / PubMed / Full text

GHSR

The genetic component of human longevity: New insights from the analysis of pathway-based SNP-SNP interactions. / 06.2018 / PubMed / Full text
Genomewide meta-analysis identifies loci associated with IGF-I and IGFBP-3 levels with impact on age-related traits. / 10.2016 / PubMed / Full text
Ghrelin accelerates synapse formation and activity development in cultured cortical networks. / 17.04.2014 / PubMed / Full text

GLO1

The AGE-RAGE Axis: Implications for Age-Associated Arterial Diseases. / 2017 / PubMed / Full text
Methylglyoxal-induced dicarbonyl stress in aging and disease: first steps towards glyoxalase 1-based treatments. / 01.10.2016 / PubMed / Full text
Glyoxalase I reduces glycative and oxidative stress and prevents age-related endothelial dysfunction through modulation of endothelial nitric oxide synthase phosphorylation. / 06.2014 / PubMed / Full text

GNE

Aberrant mitochondrial morphology and function associated with impaired mitophagy and DNM1L-MAPK/ERK signaling are found in aged mutant Parkinsonian LRRK2 mice. / 10.12.2020 / PubMed / Full text
Effects of altered sialic acid biosynthesis on [i]N[/i]-linked glycan branching and cell surface interactions. / 09.06.2017 / PubMed / Full text
Sialyllactose ameliorates myopathic phenotypes in symptomatic GNE myopathy model mice. / 10.2014 / PubMed / Full text

GPT

Brain Structural-Behavioral Correlates Underlying Grooved Pegboard Test Performance Across Lifespan. / 07.07.2020 / PubMed / Full text
Effects of tDCS of Dorsolateral Prefrontal Cortex on Dual-Task Performance Involving Manual Dexterity and Cognitive Task in Healthy Older Adults. / 2019 / PubMed / Full text
A comparative study of glutamate oxaloacetate transaminase (GOT) and glutamate pyruvate transaminase (GPT) levels in the saliva of diabetic and normal patients. / 10.2014 / PubMed / Full text

GPX2

RNA Exosome Complex-Mediated Control of Redox Status in Pluripotent Stem Cells. / 10.10.2017 / PubMed / Full text
Maternal obesity in the rat impairs male offspring aging of the testicular antioxidant defence system. / 09.2017 / PubMed / Full text
FOXM1 regulates proliferation, senescence and oxidative stress in keratinocytes and cancer cells. / 07.2016 / PubMed / Full text

GRK5

Downregulation of thromboxane A2 and angiotensin II type 1 receptors associated with aging-related decrease in internal anal sphincter tone. / 01.05.2019 / PubMed / Full text
GRK5 - A Functional Bridge Between Cardiovascular and Neurodegenerative Disorders. / 2018 / PubMed / Full text
GRK5 dysfunction accelerates tau hyperphosphorylation in APP (swe) mice through impaired cholinergic activity. / 07.05.2014 / PubMed / Full text

GSTP1

Age-associated changes in GSH S-transferase gene/proteins in livers of rats. / 12.2018 / PubMed / Full text
Lead-Related Genetic Loci, Cumulative Lead Exposure and Incident Coronary Heart Disease: The Normative Aging Study. / 2016 / PubMed / Full text
Contribution of genetic polymorphisms on functional status at very old age: a gene-based analysis of 38 genes (311 SNPs) in the oxidative stress pathway. / 04.2014 / PubMed / Full text

HAS2

Age-related changes in cyclic phosphatidic acid-induced hyaluronic acid synthesis in human fibroblasts. / 01.2018 / PubMed / Full text
Microvasculature of the Mouse Cerebral Cortex Exhibits Increased Accumulation and Synthesis of Hyaluronan With Aging. / 01.06.2017 / PubMed / Full text
Hyaluronan synthase 2 regulates fibroblast senescence in pulmonary fibrosis. / 09.2016 / PubMed / Full text

HDAC5

Emerging roles for histone deacetylases in age-related muscle atrophy. / 27.10.2016 / PubMed / Full text
AMPK and HIF signaling pathways regulate both longevity and cancer growth: the good news and the bad news about survival mechanisms. / 08.2016 / PubMed / Full text
AMPK/Snf1 signaling regulates histone acetylation: Impact on gene expression and epigenetic functions. / 08.2016 / PubMed / Full text

HES1

A Single-Cell Transcriptomic Atlas of Human Skin Aging. / 23.11.2020 / PubMed / Full text
Hypothesis: cell signalling influences age-related risk of colorectal cancer. / 01.2015 / PubMed / Full text
A transcriptional roadmap to the senescence and differentiation of human oral keratinocytes. / 01.2015 / PubMed / Full text

HLA-A

Reduced expression of the lncRNA NRON is a potential hallmark of the CMV-amplified CD8 T cell accumulations commonly seen in older humans. / 01.2019 / PubMed / Full text
Cytomegalovirus-Specific T Cells Restricted by HLA-Cw*0702 Increase Markedly with Age and Dominate the CD8 T-Cell Repertoire in Older People. / 2017 / PubMed / Full text
Telomere Length as an Indicator of the Robustness of B- and T-Cell Response to Influenza in Older Adults. / 15.10.2015 / PubMed / Full text

HLA-DRB1

The pathophysiology of polymyalgia rheumatica, small pieces of a big puzzle. / 11.2020 / PubMed / Full text
Association and interaction effects of Alzheimer's disease-associated genes and lifestyle on cognitive aging in older adults in a Taiwanese population. / 11.04.2017 / PubMed / Full text
[Clinical and genetic characteristics of long-livers in Moscow region]. / 2013 / PubMed

HRAS

How do combinations of unhealthy behaviors relate to attitudinal factors and subjective health among the adult population in the Netherlands? / 03.04.2020 / PubMed / Full text
Elucidating Proteoform Dynamics Underlying the Senescence Associated Secretory Phenotype. / 07.02.2020 / PubMed / Full text
"Back to the future": Influence of beliefs regarding the future on TTO answers. / 12.01.2016 / PubMed / Full text

HSF2

Identification of key genes and transcription factors in aging mesenchymal stem cells by DNA microarray data. / 15.04.2019 / PubMed / Full text
Nutrition and water temperature regulate the expression of heat-shock proteins in golden pompano larvae (Trachinotus ovata, Limmaeus 1758). / 04.2019 / PubMed / Full text
Effects of intrinsic aerobic capacity, aging and voluntary running on skeletal muscle sirtuins and heat shock proteins. / 15.06.2016 / PubMed / Full text

HSPA1A

Vitamin D3 treatment regulates apoptosis, antioxidant defense system, and DNA integrity in the epididymal sperm of an aged rat model. / 12.2019 / PubMed / Full text
The effect of aging on the autophagic and heat shock response in human peripheral blood mononuclear cells. / 01.09.2018 / PubMed / Full text
The Brewed Rice Vinegar Kurozu Increases HSPA1A Expression and Ameliorates Cognitive Dysfunction in Aged P8 Mice. / 2016 / PubMed / Full text

IDH1

GBM-associated mutations and altered protein expression are more common in young patients. / 25.10.2016 / PubMed / Full text
IDH1 Associated with Neuronal Apoptosis in Adult Rats Brain Following Intracerebral Hemorrhage. / 07.2017 / PubMed / Full text
2-Hydroxyglutarate Inhibits ATP Synthase and mTOR Signaling. / 01.09.2015 / PubMed / Full text

IFI16

Transcriptomic analysis of purified human cortical microglia reveals age-associated changes. / 08.2017 / PubMed / Full text
IFI16, an amplifier of DNA-damage response: Role in cellular senescence and aging-associated inflammatory diseases. / 07.2016 / PubMed / Full text
Genomic regulation of senescence and innate immunity signaling in the retinal pigment epithelium. / 06.2015 / PubMed / Full text

IGF2R

Insulin-like factor-2 receptor rs9456497 G genotype overrepresents in males of average population and its correlation with cardiovascular risks. / 05-06.2018 / PubMed / Full text
A serum miRNA profile of human longevity: findings from the Baltimore Longitudinal Study of Aging (BLSA). / 07.11.2016 / PubMed / Full text
Environmental tobacco smoke increases autophagic effects but decreases longevity associated with Sirt-1 protein expression in young C57BL mice hearts. / 28.06.2016 / PubMed / Full text

IL15

Moderate physical activity associated with a higher naïve/memory T-cell ratio in healthy old individuals: potential role of IL15. / 27.04.2020 / PubMed / Full text
From comorbidities of chronic obstructive pulmonary disease to identification of shared molecular mechanisms by data integration. / 22.11.2016 / PubMed / Full text
Human monocytes have increased IFN-γ-mediated IL-15 production with age alongside altered IFN-γ receptor signaling. / 05-06.2014 / PubMed / Full text

IL1A

IL1B triggers inflammatory cytokine production in bovine oviduct epithelial cells and induces neutrophil accumulation via CCL2. / 25.10.2020 / PubMed / Full text
Age-associated mRNA expression changes in bovine endometrial cells in vitro. / 14.08.2017 / PubMed / Full text
Age-dependent changes in inflammation and extracellular matrix in bovine oviduct epithelial cells during the post-ovulatory phase. / 09.2016 / PubMed / Full text

INPP5D

Late Onset Alzheimer's Disease Risk Variants in Cognitive Decline: The PATH Through Life Study. / 2017 / PubMed / Full text
Association and interaction effects of Alzheimer's disease-associated genes and lifestyle on cognitive aging in older adults in a Taiwanese population. / 11.04.2017 / PubMed / Full text
Gene-based aggregate SNP associations between candidate AD genes and cognitive decline. / 04.2016 / PubMed / Full text

IRF7

Transcriptome analysis reveals immune-related gene expression changes with age in giant panda ([i]Ailuropoda melanoleuca[/i]) blood. / 14.01.2019 / PubMed / Full text
Sirtuin 1-Chromatin-Binding Dynamics Points to a Common Mechanism Regulating Inflammatory Targets in SIV Infection and in the Aging Brain. / 06.2018 / PubMed / Full text
Age-related changes in murine myometrial transcript profile are mediated by exposure to the female sex hormones. / 02.2016 / PubMed / Full text

KCNMB2

CSF protein changes associated with hippocampal sclerosis risk gene variants highlight impact of GRN/PGRN. / 04.2017 / PubMed / Full text
Gene-based association study of genes linked to hippocampal sclerosis of aging neuropathology: GRN, TMEM106B, ABCC9, and KCNMB2. / 05.2017 / PubMed / Full text
Hippocampal Sclerosis of Aging, a Common Alzheimer's Disease 'Mimic': Risk Genotypes are Associated with Brain Atrophy Outside the Temporal Lobe. / 2016 / PubMed / Full text

KIN

The noncanonical small heat shock protein HSP-17 from [i]Caenorhabditis elegans[/i] is a selective protein aggregase. / 06.03.2020 / PubMed / Full text
KIN-4/MAST kinase promotes PTEN-mediated longevity of Caenorhabditis elegans via binding through a PDZ domain. / 06.2019 / PubMed / Full text
Adenine type and diphenyl urea derived cytokinins improve the postharvest performance of [i]Iris germanica[/i] L. cut scapes. / 11.2018 / PubMed / Full text

KIT

Prediction of ovarian aging using ovarian expression of BMP15, GDF9, and C-KIT. / 04.2020 / PubMed / Full text
miR-19b-3p induces cell proliferation and reduces heterochromatin-mediated senescence through PLZF in goat male germline stem cells. / 06.2018 / PubMed / Full text
Comparison of Changes in the Interstitial Cells of Cajal and Neuronal Nitric Oxide Synthase-positive Neuronal Cells With Aging Between the Ascending and Descending Colon of F344 Rats. / 30.10.2017 / PubMed / Full text

LAT2

Blood glucose, amino acid profiles and nutrient transporter gene expressions in the small intestine of low and normal birthweight piglets during the early suckling period. / 05.2019 / PubMed / Full text
Skeletal muscle: from birth to old age, routes to mechanical and metabolic failure. / 2017 / PubMed / Full text
Dihydrotestosterone treatment rescues the decline in protein synthesis as a result of sarcopenia in isolated mouse skeletal muscle fibres. / 02.2017 / PubMed / Full text

LCN2

Anthropometric and glucometabolic changes in an aged mouse model of lipocalin-2 overexpression. / 01.2019 / PubMed / Full text
Expression patterns and changes of the LCN2 gene in the testes of induced cryptorchidism and busulfan-treated mice. / 12.2017 / PubMed / Full text
TCF7L1 promotes skin tumorigenesis independently of β-catenin through induction of LCN2. / 03.05.2017 / PubMed / Full text

LCT

Functional MRI of Letter Cancellation Task Performance in Older Adults. / 2019 / PubMed / Full text
Milk Intake at Midlife and Cognitive Decline over 20 Years. The Atherosclerosis Risk in Communities (ARIC) Study. / 17.10.2017 / PubMed / Full text
Frailty phenotype and the role of levodopa challenge test in geriatric inpatients with mild parkinsonian signs. / 08.2017 / PubMed / Full text

LGR5

Thyroid hormone activates Wnt/β-catenin signaling involved in adult epithelial development during intestinal remodeling in Xenopus laevis. / 08.2016 / PubMed / Full text
An EphB-Abl signaling pathway is associated with intestinal tumor initiation and growth. / 01.04.2015 / PubMed / Full text
Cancer stem cells in Helicobacter pylori infection and aging: Implications for gastric carcinogenesis. / 15.08.2014 / PubMed / Full text

LOXL2

Lysyl Oxidase-Like 2 Protects against Progressive and Aging Related Knee Joint Osteoarthritis in Mice. / 27.09.2019 / PubMed / Full text
Lysyl oxidase-like 2 depletion is protective in age-associated vascular stiffening. / 01.07.2019 / PubMed / Full text
Blood Vessel Basement Membrane Alterations in Human Retinal Microaneurysms During Aging. / 01.02.2017 / PubMed / Full text

LRP6

Low-density lipoprotein receptor-related protein 6-mediated signaling pathways and associated cardiovascular diseases: diagnostic and therapeutic opportunities. / 04.2020 / PubMed / Full text
Wnt signaling in age-related macular degeneration: human macular tissue and mouse model. / 17.10.2015 / PubMed / Full text
WNT1-induced Secreted Protein-1 (WISP1), a Novel Regulator of Bone Turnover and Wnt Signaling. / 29.05.2015 / PubMed / Full text

LSR

Age-related changes in regiospecific expression of Lipolysis Stimulated Receptor (LSR) in mice brain. / 2019 / PubMed / Full text
Discriminating Alzheimer's disease progression using a new hippocampal marker from T1-weighted MRI: The local surface roughness. / 01.04.2019 / PubMed / Full text
Wave intensity analysis in mice: age-related changes in WIA peaks and correlation with cardiac indexes. / 04.2017 / PubMed / Full text

MAF

Biocatalytic Degradation Efficiency of Postconsumer Polyethylene Terephthalate Packaging Determined by Their Polymer Microstructures. / 17.07.2019 / PubMed / Full text
Binocular and Accommodative Characteristics in a Normal Population. / 03.2017 / PubMed / Full text
Association of Klotho and interleukin 6 gene polymorphisms with aging in Han Chinese population. / 12.2014 / PubMed / Full text

MAF1

Beyond regulation of pol III: Role of MAF1 in growth, metabolism, aging and cancer. / 04.2018 / PubMed / Full text
Loss of the RNA polymerase III repressor MAF1 confers obesity resistance. / 01.05.2015 / PubMed / Full text
Distinct regulation of Maf1 for lifespan extension by Protein kinase A and Sch9. / 02.2015 / PubMed / Full text

MAP1B

SerThr-PhosphoProteome of Brain from Aged PINK1-KO A53T-SNCA Mice Reveals pT1928-MAP1B and pS3781-ANK2 Deficits, as Hub between Autophagy and Synapse Changes. / 04.07.2019 / PubMed / Full text
NOS1 and SNAP25 polymorphisms are associated with Attention-Deficit/Hyperactivity Disorder symptoms in adults but not in children. / 04.2016 / PubMed / Full text
Loss of MAP function leads to hippocampal synapse loss and deficits in the Morris Water Maze with aging. / 21.05.2014 / PubMed / Full text

MAP3K3

miR-188 promotes senescence of lineage-negative bone marrow cells by targeting MAP3K3 expression. / 08.2017 / PubMed / Full text
Functions of miR-9 and miR-9* during Aging in SAMP8 Mice and Their Possible Mechanisms. / 06.2015 / PubMed / Full text
Global Characteristics of CSIG-Associated Gene Expression Changes in Human HEK293 Cells and the Implications for CSIG Regulating Cell Proliferation and Senescence. / 2015 / PubMed / Full text

MAPK14

Micro-RNAS Regulate Metabolic Syndrome-induced Senescence in Porcine Adipose Tissue-derived Mesenchymal Stem Cells through the P16/MAPK Pathway. / 10.2018 / PubMed / Full text
G protein-coupled receptor kinase 4-induced cellular senescence and its senescence-associated gene expression profiling. / 15.11.2017 / PubMed / Full text
Targeting genes in insulin-associated signalling pathway, DNA damage, cell proliferation and cell differentiation pathways by tocotrienol-rich fraction in preventing cellular senescence of human diploid fibroblasts. / 11-12.2015 / PubMed / Full text

MAPK3

A tyrosine kinase-activating variant Asn666Ser in PDGFRB causes a progeria-like condition in the severe end of Penttinen syndrome. / 04.2019 / PubMed / Full text
Micro-RNAS Regulate Metabolic Syndrome-induced Senescence in Porcine Adipose Tissue-derived Mesenchymal Stem Cells through the P16/MAPK Pathway. / 10.2018 / PubMed / Full text
Crosstalk from cAMP to ERK1/2 emerges during postnatal maturation of nociceptive neurons and is maintained during aging. / 01.07.2017 / PubMed / Full text

MAX

Validation of the MedUseQ: A Self-Administered Screener for Older Adults to Assess Medication Use Problems. / 10.2019 / PubMed / Full text
Midlife plasma vitamin D concentrations and performance in different cognitive domains assessed 13 years later. / 28.05.2015 / PubMed / Full text
Effect of long-term care use on Medicare and Medicaid expenditures for dual eligible and non-dual eligible elderly beneficiaries. / 2013 / PubMed / Full text

MCAT

Small molecules as therapeutic drugs for Alzheimer's disease. / 04.2019 / PubMed / Full text
Overexpression of catalase in mice reduces age-related oxidative stress and maintains sperm production. / 11.2016 / PubMed / Full text
Oxidative Stress Promotes Peroxiredoxin Hyperoxidation and Attenuates Pro-survival Signaling in Aging Chondrocytes. / 25.03.2016 / PubMed / Full text

MCM7

Changes in MCM2-7 proteins at senescence. / 27.07.2019 / PubMed / Full text
Inhibition of CIP2A attenuates tumor progression by inducing cell cycle arrest and promoting cellular senescence in hepatocellular carcinoma. / 08.01.2018 / PubMed / Full text
Proton irradiation impacts age-driven modulations of cancer progression influenced by immune system transcriptome modifications from splenic tissue. / 09.2015 / PubMed / Full text

MEF2A

Myocyte enhancer factor 2A delays vascular endothelial cell senescence by activating the PI3K/p-Akt/SIRT1 pathway. / 10.06.2019 / PubMed / Full text
MEF2A alters the proliferation, inflammation-related gene expression profiles and its silencing induces cellular senescence in human coronary endothelial cells. / 18.03.2019 / PubMed / Full text
Identification of key genes and transcription factors in aging mesenchymal stem cells by DNA microarray data. / 15.04.2019 / PubMed / Full text

MGA

Fatigue at baseline is associated with geriatric impairments and represents an adverse prognostic factor in older patients with a hematological malignancy. / 11.2018 / PubMed / Full text
Geriatric assessment in oncology: Moving the concept forward. The 20 years of experience of the Centre Léon Bérard geriatric oncology program. / 11.2018 / PubMed / Full text
Degree of Peripheral Thyroxin Deiodination, Frailty, and Long-Term Survival in Hospitalized Older Patients. / 01.05.2018 / PubMed / Full text

MGP

Circulating Vitamin K Is Inversely Associated with Incident Cardiovascular Disease Risk among Those Treated for Hypertension in the Health, Aging, and Body Composition Study (Health ABC). / 05.2017 / PubMed / Full text
Aging related methylation influences the gene expression of key control genes in colorectal cancer and adenoma. / 21.12.2016 / PubMed / Full text
[Bone metabolism and cardiovascular function update. Cross link of hypertension, bone loss and vascular calcification - common back grounds in renin angiotensin system with anti-aging aspect -]. / 07.2014 / PubMed / Full text

MGRN1

Chronic and age-dependent effects of the spongiform neurodegeneration-associated MGRN1 E3 ubiquitin ligase on mitochondrial homeostasis. / 06.2019 / PubMed / Full text
Aging Triggers Cytoplasmic Depletion and Nuclear Translocation of the E3 Ligase Mahogunin: A Function for Ubiquitin in Neuronal Survival. / 04.05.2017 / PubMed / Full text
Mahogunin Ring Finger-1 (MGRN1), a Multifaceted Ubiquitin Ligase: Recent Unraveling of Neurobiological Mechanisms. / 09.2016 / PubMed / Full text

MLKL

Remifentanil preconditioning protects against hypoxia-induced senescence and necroptosis in human cardiac myocytes [i]in vitro[/i]. / 25.06.2020 / PubMed / Full text
Necroptosis increases with age and is reduced by dietary restriction. / 08.2018 / PubMed / Full text
RIPK1-RIPK3-MLKL-dependent necrosis promotes the aging of mouse male reproductive system. / 15.08.2017 / PubMed / Full text

MMP12

Macrophage-Restricted Shp2 Tyrosine Phosphatase Acts as a Rheostat for MMP12 through TGF-β Activation in the Prevention of Age-Related Emphysema in Mice. / 01.10.2017 / PubMed / Full text
Differential Matrix Metalloprotease (MMP) Expression Profiles Found in Aged Gingiva. / 2016 / PubMed / Full text
Matrix metalloproteinase-12 is an essential mediator of acute and chronic arterial stiffening. / 26.11.2015 / PubMed / Full text

MMP7

Retinoic acid promotes in vitro follicle activation in the cat ovary by regulating expression of matrix metalloproteinase 9. / 2018 / PubMed / Full text
High-Throughput Characterization of Blood Serum Proteomics of IBD Patients with Respect to Aging and Genetic Factors. / 01.2017 / PubMed / Full text
Metzincins and related genes in experimental renal ageing: towards a unifying fibrosis classifier across species. / 06.2014 / PubMed / Full text

MS4A4E

Recent studies on cellular and molecular mechanisms in Alzheimer's disease: focus on epigenetic factors and histone deacetylase. / 28.03.2018 / PubMed / Full text
Late Onset Alzheimer's Disease Risk Variants in Cognitive Decline: The PATH Through Life Study. / 2017 / PubMed / Full text
Association and interaction effects of Alzheimer's disease-associated genes and lifestyle on cognitive aging in older adults in a Taiwanese population. / 11.04.2017 / PubMed / Full text

MST1

[Expression relationship of Hippo signaling molecules and ovarian germline stem cell markers in the ovarian aging process of women and mice]. / 25.06.2019 / PubMed
High-Throughput Characterization of Blood Serum Proteomics of IBD Patients with Respect to Aging and Genetic Factors. / 01.2017 / PubMed / Full text
Impaired liver regeneration in aged mice can be rescued by silencing Hippo core kinases MST1 and MST2. / 01.2017 / PubMed / Full text

MT1A

Pharmacological advantages of melatonin in immunosenescence by improving activity of T lymphocytes. / 07.2016 / PubMed / Full text
A novel strain of Lactobacillus mucosae isolated from a Gaotian villager improves in vitro and in vivo antioxidant as well as biological properties in D-galactose-induced aging mice. / 02.2016 / PubMed / Full text
Contribution of genetic polymorphisms on functional status at very old age: a gene-based analysis of 38 genes (311 SNPs) in the oxidative stress pathway. / 04.2014 / PubMed / Full text

MTNR1B

Analysis of MTNR1B gene polymorphisms in relationship with IRS2 gene variants, epicardial fat thickness, glucose homeostasis and cognitive performance in the elderly. / 2017 / PubMed / Full text
Melatonin and the pathologies of weakened or dysregulated circadian oscillators. / 01.2017 / PubMed / Full text
Association of osteoporosis with genetic variants of circadian genes in Chinese geriatrics. / 04.2016 / PubMed / Full text

MUC5AC

InflammAging at Ocular Surface: Clinical and Biomolecular Analyses in Healthy Volunteers. / 01.04.2019 / PubMed / Full text
Expression of polycomb protein BMI-1 maintains the plasticity of basal bronchial epithelial cells. / 08.2016 / PubMed / Full text
Immunohistochemical Expressions of MUC2, MUC5AC, and MUC6 in Normal, Helicobacter pylori Infected and Metaplastic Gastric Mucosa of Children and Adolescents. / 08.2015 / PubMed / Full text

MUS81

Mechanistic link between DNA damage sensing, repairing and signaling factors and immune signaling. / 2019 / PubMed / Full text
MUS81 is associated with cell proliferation and cisplatin sensitivity in serous ovarian cancer. / 05.08.2016 / PubMed / Full text
Acute MUS81 depletion leads to replication fork slowing and a constitutive DNA damage response. / 10.11.2015 / PubMed / Full text

NDRG1

Cx43 phosphorylation-mediated effects on ERK and Akt protect against ischemia reperfusion injury and alter the stability of the stress-inducible protein NDRG1. / 02.08.2019 / PubMed / Full text
Extended Multiplexing of Tandem Mass Tags (TMT) Labeling Reveals Age and High Fat Diet Specific Proteome Changes in Mouse Epididymal Adipose Tissue. / 05.2017 / PubMed / Full text
mTOR regulates the expression of DNA damage response enzymes in long-lived Snell dwarf, GHRKO, and PAPPA-KO mice. / 02.2017 / PubMed / Full text

NDRG2

NDRG2 Expression Correlates with Neurofibrillary Tangles and Microglial Pathology in the Ageing Brain. / 04.01.2020 / PubMed / Full text
The pathological roles of NDRG2 in Alzheimer's disease, a study using animal models and APPwt-overexpressed cells. / 08.2017 / PubMed / Full text
Review: Astrocytes in Alzheimer's disease and other age-associated dementias: a supporting player with a central role. / 06.2017 / PubMed / Full text

NDUFB8

Effect of Melatonin on Rat Heart Mitochondria in Acute Heart Failure in Aged Rats. / 23.05.2018 / PubMed / Full text
Maternal nutrient restriction in baboon programs later-life cellular growth and respiration of cultured skin fibroblasts: a potential model for the study of aging-programming interactions. / 06.2018 / PubMed / Full text
Resveratrol Protects SAMP8 Brain Under Metabolic Stress: Focus on Mitochondrial Function and Wnt Pathway. / 04.2017 / PubMed / Full text

NFKB1

NFKB1 gene single-nucleotide polymorphisms: implications for graft-versus-host disease in allogeneic hematopoietic stem cell transplantation. / 03.2020 / PubMed / Full text
The Inflammatory Transcription Factors NFκB, STAT1 and STAT3 Drive Age-Associated Transcriptional Changes in the Human Kidney. / 12.2015 / PubMed / Full text
NFKB1: a suppressor of inflammation, ageing and cancer. / 05.2016 / PubMed / Full text

NOA1

The dependence of leaf senescence on the balance between 1-aminocyclopropane-1-carboxylate acid synthase 1 (ACS1)-catalysed ACC generation and nitric oxide-associated 1 (NOS1)-dependent NO accumulation in Arabidopsis. / 07.2019 / PubMed / Full text
Low concentrations of salicylic acid delay methyl jasmonate-induced leaf senescence by up-regulating nitric oxide synthase activity. / 09.2016 / PubMed / Full text
Two homologous protein S-acyltransferases, PAT13 and PAT14, cooperatively regulate leaf senescence in Arabidopsis. / 10.2015 / PubMed / Full text

NOG

The p53 Pathway Controls SOX2-Mediated Reprogramming in the Adult Mouse Spinal Cord. / 11.10.2016 / PubMed / Full text
Non-Lethal Ionizing Radiation Promotes Aging-Like Phenotypic Changes of Human Hematopoietic Stem and Progenitor Cells in Humanized Mice. / 2015 / PubMed / Full text
Nucleolar GTPase NOG-1 regulates development, fat storage, and longevity through insulin/IGF signaling in C. elegans. / 01.2014 / PubMed / Full text

NOTCH3

Whole-Exome Sequencing of an Exceptional Longevity Cohort. / 16.08.2019 / PubMed / Full text
Mendelian adult-onset leukodystrophy genes in Alzheimer's disease: critical influence of CSF1R and NOTCH3. / 06.2018 / PubMed / Full text
Length of paternal lifespan is manifested in the DNA methylome of their nonagenarian progeny. / 13.10.2015 / PubMed / Full text

NOX1

Identification of the mechanisms by which age alters the mechanosensitivity of mesenchymal stromal cells on substrates of differing stiffness: Implications for osteogenesis and angiogenesis. / 15.04.2017 / PubMed / Full text
Antioxidant Supplementation Modulates Age-Related Placental Bed Morphology and Reproductive Outcome in Mice. / 09.2015 / PubMed / Full text
NADPH oxidase NOX1 is involved in activation of protein kinase C and premature senescence in early stage diabetic kidney. / 06.2015 / PubMed / Full text

NPM1

Flow cytometric identification and cell-line establishment of macrophages in naked mole-rats. / 29.11.2019 / PubMed / Full text
Sirtuin 7 in cell proliferation, stress and disease: Rise of the Seventh Sirtuin! / 03.2015 / PubMed / Full text
Comparative interactomes of SIRT6 and SIRT7: Implication of functional links to aging. / 07.2014 / PubMed / Full text

OCM

Survival Outcomes in Octogenarian and Nonagenarian Patients Treated with First-line Androgen Deprivation Therapy for Organ-confined Prostate Cancer. / 12.2018 / PubMed / Full text
Comorbidity and age cannot explain variation in life expectancy associated with treatment of non-metastatic prostate cancer. / 07.2017 / PubMed / Full text
Changing Trends in Surgical Management of Prostate Cancer: The End of Overtreatment? / 08.2015 / PubMed / Full text

OSM

Age Differences in Sexual Minority Stress and the Importance of Friendship in Later Life. / 04.11.2020 / PubMed / Full text
STAT3-mediated SMAD3 activation underlies Oncostatin M-induced Senescence. / 16.02.2017 / PubMed / Full text
Caenorhabditis elegans OSM-11 signaling regulates SKN-1/Nrf during embryonic development and adult longevity and stress response. / 01.04.2015 / PubMed / Full text

OTX2

Tau Deficiency Down-Regulated Transcription Factor Orthodenticle Homeobox 2 Expression in the Dopaminergic Neurons in Ventral Tegmental Area and Caused No Obvious Motor Deficits in Mice. / 01.03.2018 / PubMed / Full text
Induced Pluripotent Stem Cell-Derived Dopaminergic Neurons from Adult Common Marmoset Fibroblasts. / 01.09.2017 / PubMed / Full text
Amyloid Precursor-Like Protein 2 deletion-induced retinal synaptopathy related to congenital stationary night blindness: structural, functional and molecular characteristics. / 08.06.2016 / PubMed / Full text

OXR1

Oxidation resistance 1 is a novel senolytic target. / 08.2018 / PubMed / Full text
Cloning of cDNA encoding a Bombyx mori homolog of human oxidation resistance 1 (OXR1) protein from diapause eggs, and analyses of its expression and function. / 09.2014 / PubMed / Full text
Oxidation resistance 1 is essential for protection against oxidative stress and participates in the regulation of aging in Caenorhabditis elegans. / 08.2014 / PubMed / Full text

PABPN1

Dysfunctional transcripts are formed by alternative polyadenylation in OPMD. / 26.09.2017 / PubMed / Full text
PABPN1-Dependent mRNA Processing Induces Muscle Wasting. / 05.2016 / PubMed / Full text
A novel feed-forward loop between ARIH2 E3-ligase and PABPN1 regulates aging-associated muscle degeneration. / 04.2014 / PubMed / Full text

PAPPA

Proteomic profiling of follicle fluids after superstimulation in one-month-old lambs. / 02.2018 / PubMed / Full text
Genome-wide association study and annotating candidate gene networks affecting age at first calving in Nellore cattle. / 12.2017 / PubMed / Full text
mTOR regulates the expression of DNA damage response enzymes in long-lived Snell dwarf, GHRKO, and PAPPA-KO mice. / 02.2017 / PubMed / Full text

PER1

Quercetin, caffeic acid and resveratrol regulate circadian clock genes and aging-related genes in young and old human lung fibroblast cells. / 02.2020 / PubMed / Full text
Is the aging human ovary still ticking?: Expression of clock-genes in luteinized granulosa cells of young and older women. / 21.11.2018 / PubMed / Full text
Ectopic expression of NnPER1, a Nelumbo nucifera 1-cysteine peroxiredoxin antioxidant, enhances seed longevity and stress tolerance in Arabidopsis. / 11.2016 / PubMed / Full text

PF4

TMT-Based Quantitative Proteomic Analysis Reveals Proteomic Changes Involved in Longevity. / 07.2019 / PubMed / Full text
Effects of collagen peptides intake on skin ageing and platelet release in chronologically aged mice revealed by cytokine array analysis. / 01.2018 / PubMed / Full text
Changes in platelet morphology and function during 24 hours of storage. / 2014 / PubMed / Full text

PHB

Ubiquinol-cytochrome C reductase core protein II promotes tumorigenesis by facilitating p53 degradation. / 02.2019 / PubMed / Full text
Analysis of the effect of the mitochondrial prohibitin complex, a context-dependent modulator of longevity, on the C. elegans metabolome. / 11.2015 / PubMed / Full text
Prohibitin-mediated lifespan and mitochondrial stress implicate SGK-1, insulin/IGF and mTORC2 in C. elegans. / 2014 / PubMed / Full text

PIK3CG

Myocyte enhancer factor 2A delays vascular endothelial cell senescence by activating the PI3K/p-Akt/SIRT1 pathway. / 10.06.2019 / PubMed / Full text
MEF2A alters the proliferation, inflammation-related gene expression profiles and its silencing induces cellular senescence in human coronary endothelial cells. / 18.03.2019 / PubMed / Full text
Sequencing of 2 subclinical atherosclerosis candidate regions in 3669 individuals: Cohorts for Heart and Aging Research in Genomic Epidemiology (CHARGE) Consortium Targeted Sequencing Study. / 06.2014 / PubMed / Full text

PLD2

Age-related distribution and potential role of SNCB in topographically different retinal areas of the common marmoset Callithrix jacchus, including the macula. / 08.2019 / PubMed / Full text
Role of phospholipase D in the lifespan of Caenorhabditis elegans. / 06.04.2018 / PubMed / Full text
Phospholipase D2 downregulation induces cellular senescence through a reactive oxygen species-p53-p21Cip1/WAF1 pathway. / 25.08.2014 / PubMed / Full text

PLIN2

Cardiac overexpression of perilipin 2 induces atrial steatosis, connexin 43 remodeling, and atrial fibrillation in aged mice. / 01.12.2019 / PubMed / Full text
HDAC6 Suppresses Age-Dependent Ectopic Fat Accumulation by Maintaining the Proteostasis of PLIN2 in Drosophila. / 09.10.2017 / PubMed / Full text
Effects of immobilization and aerobic training on proteins related to intramuscular substrate storage and metabolism in young and older men. / 03.2016 / PubMed / Full text

PLN

An analysis of the costs of treating aged patients in a large clinical hospital in Poland under the pressure of recent demographic trends. / 2020 / PubMed / Full text
Molecular evidence on the protective effect of ellagic acid on phosalone-induced senescence in rat embryonic fibroblast cells. / 02.2017 / PubMed / Full text
Health outcomes and economic consequences of using angiotensin-converting enzyme inhibitors in comparison with angiotensin receptor blockers in the treatment of arterial hypertension in the contemporary Polish setting. / 2016 / PubMed / Full text

POSTN

A Transcriptome Study of Progeroid Neurocutaneous Syndrome Reveals POSTN As a New Element in Proline Metabolic Disorder. / 12.2018 / PubMed / Full text
Proteomic profiling of follicle fluids after superstimulation in one-month-old lambs. / 02.2018 / PubMed / Full text
Age-dependent changes in inflammation and extracellular matrix in bovine oviduct epithelial cells during the post-ovulatory phase. / 09.2016 / PubMed / Full text

POT1

MiR-185 targets POT1 to induce telomere dysfunction and cellular senescence. / 18.07.2020 / PubMed / Full text
Seryl tRNA synthetase cooperates with POT1 to regulate telomere length and cellular senescence. / 2019 / PubMed / Full text
A newly identified berberine derivative induces cancer cell senescence by stabilizing endogenous G-quadruplexes and sparking a DNA damage response at the telomere region. / 03.11.2015 / PubMed / Full text

PPARG

The PPARG Pro12Ala Polymorphism and 20-year Cognitive Decline: Race and Sex Heterogeneity. / 04-06.2018 / PubMed / Full text
The ADAMTS9 gene is associated with cognitive aging in the elderly in a Taiwanese population. / 2017 / PubMed / Full text
[Genotype and allele frequencies of UCP and PPAR gene families in residents of besieged Leningrad and in the control group]. / 2014 / PubMed

PPARGC1A

Maternal ageing impairs mitochondrial DNA kinetics during early embryogenesis in mice. / 08.07.2019 / PubMed / Full text
Molecular evolutionary patterns of NAD /Sirtuin aging signaling pathway across taxa. / 2017 / PubMed / Full text
Synergistic effect of high charge and energy particle radiation and chronological age on biomarkers of oxidative stress and tissue degeneration: a ground-based study using the vertebrate laboratory model organism Oryzias latipes. / 2014 / PubMed / Full text

PRDX1

Active vitamin D supplementation alleviates initiation and progression of nonalcoholic fatty liver disease by repressing the p53 pathway. / 15.01.2020 / PubMed / Full text
PRDX1 and MTH1 cooperate to prevent ROS-mediated inhibition of telomerase. / 01.05.2018 / PubMed / Full text
Proteomic profiling of follicle fluids after superstimulation in one-month-old lambs. / 02.2018 / PubMed / Full text

PRDX3

Proteomic analyses reveal that ginsenoside Rg3([i]S[/i]) partially reverses cellular senescence in human dermal fibroblasts by inducing peroxiredoxin. / 01.2020 / PubMed / Full text
Late life maintenance and enhancement of functional exercise capacity in low and high responding rats after low intensity treadmill training. / 01.10.2019 / PubMed / Full text
The impact of preserved Klotho gene expression on antioxidative stress activity in healthy kidney. / 01.08.2018 / PubMed / Full text

PRDX6

Dentate Gyrus Peroxiredoxin 6 Levels Discriminate Aged Unimpaired From Impaired Rats in a Spatial Memory Task. / 2019 / PubMed / Full text
Targeting genes in insulin-associated signalling pathway, DNA damage, cell proliferation and cell differentiation pathways by tocotrienol-rich fraction in preventing cellular senescence of human diploid fibroblasts. / 11-12.2015 / PubMed / Full text
Advancing age increases sperm chromatin damage and impairs fertility in peroxiredoxin 6 null mice. / 08.2015 / PubMed / Full text

PRKG1

Long-term inhibition of PDE5 ameliorates aging-induced changes in rat testis. / 15.07.2018 / PubMed / Full text
Genetic correlation and genome-wide association study (GWAS) of the length of productive life, days open, and 305-days milk yield in crossbred Holstein dairy cattle. / 29.06.2017 / PubMed / Full text
Genome wide association and linkage analyses identified three loci-4q25, 17q23.2, and 10q11.21-associated with variation in leukocyte telomere length: the Long Life Family Study. / 2013 / PubMed / Full text

PSEN2

Accelerated brain aging towards transcriptional inversion in a zebrafish model of the K115fs mutation of human PSEN2. / 2020 / PubMed / Full text
Loss of presenilin 2 age-dependently alters susceptibility to acute seizures and kindling acquisition. / 03.2020 / PubMed / Full text
Characterization of Amyloid-β Deposits in Bovine Brains. / 2016 / PubMed / Full text

PTK2B

Integrative transcriptome analyses of the aging brain implicate altered splicing in Alzheimer's disease susceptibility. / 11.2018 / PubMed / Full text
Association and interaction effects of Alzheimer's disease-associated genes and lifestyle on cognitive aging in older adults in a Taiwanese population. / 11.04.2017 / PubMed / Full text
Gene-based aggregate SNP associations between candidate AD genes and cognitive decline. / 04.2016 / PubMed / Full text

PTN

Connecting Metainflammation and Neuroinflammation Through the PTN-MK-RPTPβ/ζ Axis: Relevance in Therapeutic Development. / 2019 / PubMed / Full text
Early Disruption of Extracellular Pleiotrophin Distribution Alters Cerebellar Neuronal Circuit Development and Function. / 10.2016 / PubMed / Full text
Mass spectrometric analysis of protein tyrosine nitration in aging and neurodegenerative diseases. / 03-04.2015 / PubMed / Full text

PTPN11

Fine mapping genetic variants associated with age at puberty and sow fertility using SowPro90 genotyping array. / 01.10.2020 / PubMed / Full text
A tyrosine kinase-activating variant Asn666Ser in PDGFRB causes a progeria-like condition in the severe end of Penttinen syndrome. / 04.2019 / PubMed / Full text
GBM-associated mutations and altered protein expression are more common in young patients. / 25.10.2016 / PubMed / Full text

RAD52

Quantitative assessment of changes in cell growth, size and morphology during telomere-initiated cellular senescence in Saccharomyces cerevisiae. / 01.08.2019 / PubMed / Full text
Increased age-adjusted hazard of death associated with a common single nucleotide polymorphism of the human RAD52 gene in a cardiovascular cohort. / 10.2017 / PubMed / Full text
Functional characterization of RAD52 as a lung cancer susceptibility gene in the 12p13.33 locus. / 05.2016 / PubMed / Full text

RAN

Rapid automatized naming (RAN): effects of aging on a predictor of reading skill. / 17.08.2020 / PubMed / Full text
SCA8 RAN polySer protein preferentially accumulates in white matter regions and is regulated by eIF3F. / 01.10.2018 / PubMed / Full text
Responses to Predictable versus Random Temporally Complex Stimuli from Single Units in Auditory Thalamus: Impact of Aging and Anesthesia. / 12.10.2016 / PubMed / Full text

RCAN1

Mitochondrial dysfunction and endoplasmic reticulum stress involved in oocyte aging: an analysis using single-cell RNA-sequencing of mouse oocytes. / 08.06.2019 / PubMed / Full text
RCAN1 overexpression promotes age-dependent mitochondrial dysregulation related to neurodegeneration in Alzheimer's disease. / 12.2015 / PubMed / Full text
Chaperone-mediated autophagy regulates T cell responses through targeted degradation of negative regulators of T cell activation. / 11.2014 / PubMed / Full text

RDX

Advancing age increases sperm chromatin damage and impairs fertility in peroxiredoxin 6 null mice. / 08.2015 / PubMed / Full text
A peroxiredoxin, PRDX-2, is required for insulin secretion and insulin/IIS-dependent regulation of stress resistance and longevity. / 08.2015 / PubMed / Full text
Toxicity of the conventional energetics TNT and RDX relative to new insensitive munitions constituents DNAN and NTO in Rana pipiens tadpoles. / 04.2015 / PubMed / Full text

RECQL4

Aging in Rothmund-Thomson syndrome and related RECQL4 genetic disorders. / 01.2017 / PubMed / Full text
Bloom's syndrome: Why not premature aging?: A comparison of the BLM and WRN helicases. / 01.2017 / PubMed / Full text
Senescence induced by RECQL4 dysfunction contributes to Rothmund-Thomson syndrome features in mice. / 15.05.2014 / PubMed / Full text

RGN

Effect of senescence marker protein 30 on the proliferation and apoptosis of human lens epithelial cells SRA01/04. / 2018 / PubMed / Full text
Effect of supplementation of recombinant Regucalcin in extender on cryopreservation of spermatozoa of water buffalo (Bubalus bubalis). / 11.2017 / PubMed / Full text
Aging-associated changes in oxidative stress, cell proliferation, and apoptosis are prevented in the prostate of transgenic rats overexpressing regucalcin. / 12.2015 / PubMed / Full text

RGR

Relative growth rate in phylogenetically related deciduous and evergreen woody species. / 07.2001 / PubMed / Full text
Tolerance to herbivory and the resource availability hypothesis. / 05.2017 / PubMed / Full text
Linking size-dependent growth and mortality with architectural traits across 145 co-occurring tropical tree species. / 02.2014 / PubMed / Full text

RGS2

Downregulation of thromboxane A2 and angiotensin II type 1 receptors associated with aging-related decrease in internal anal sphincter tone. / 01.05.2019 / PubMed / Full text
Regulator of G protein signaling 2 is a key regulator of pancreatic β-cell mass and function. / 25.05.2017 / PubMed / Full text
miR-17 extends mouse lifespan by inhibiting senescence signaling mediated by MKP7. / 31.07.2014 / PubMed / Full text

RNF8

Expression of RNF8 on cochlear apoptosis and aging in mice of different ages. / 03-Apr,.2019 / PubMed
Function of RAD6B and RNF8 in spermatogenesis. / 2018 / PubMed / Full text
HTLV-1 Infection and Adult T-Cell Leukemia/Lymphoma-A Tale of Two Proteins: Tax and HBZ. / 16.06.2016 / PubMed / Full text

RORA

Novel molecular mechanisms for the adaptogenic effects of herbal extracts on isolated brain cells using systems biology. / 15.11.2018 / PubMed / Full text
Effects of circadian clock genes and environmental factors on cognitive aging in old adults in a Taiwanese population. / 11.04.2017 / PubMed / Full text
Transcriptome analysis of human cumulus cells reveals hypoxia as the main determinant of follicular senescence. / 08.2016 / PubMed / Full text

RPL11

NOL12 Repression Induces Nucleolar Stress-Driven Cellular Senescence and Is Associated with Normative Aging. / 15.06.2019 / PubMed / Full text
Protection against High-Fat-Diet-Induced Obesity in MDM2 Mice Due to Reduced p53 Activity and Enhanced Energy Expenditure. / 24.01.2017 / PubMed / Full text
Comprehensive analysis of the ubiquitinome during oncogene-induced senescence in human fibroblasts. / 2015 / PubMed / Full text

RPTOR

Endothelial replicative senescence delayed by the inhibition of MTORC1 signaling involves MicroRNA-107. / 08.2018 / PubMed / Full text
MicroRNA-188 regulates age-related switch between osteoblast and adipocyte differentiation. / 04.2015 / PubMed / Full text
Genetic analysis of TOR complex gene variation with human longevity: a nested case-control study of American men of Japanese ancestry. / 02.2015 / PubMed / Full text

S1PR1

Aging Suppresses Sphingosine-1-Phosphate Chaperone ApoM in Circulation Resulting in Maladaptive Organ Repair. / 22.06.2020 / PubMed / Full text
Profiling the lymphoid-resident T cell pool reveals modulation by age and microbiota. / 04.01.2018 / PubMed / Full text
Hypothalamic S1P/S1PR1 axis controls energy homeostasis in Middle-Aged Rodents: the reversal effects of physical exercise. / 26.12.2016 / PubMed / Full text

SCAP

Dementia outcomes after addition of proxy-based assessments for deceased or proxy-dependent participants. / 10.2019 / PubMed / Full text
Increased hepatic INSIG-SCAP-SREBP expression is associated with cholesterol metabolism disorder in assisted reproductive technology-conceived aged mice. / 03.2019 / PubMed / Full text
[Individually Safe and Realistic Correction of Antipsychotic Polypharmacy and High-dose Regimens in Japanese Patients with Chronic Schizophrenia: The SCAP method]. / 2015 / PubMed

SERPINE1

Elevated circulating HtrA4 in preeclampsia may alter endothelial expression of senescence genes. / 15.01.2020 / PubMed / Full text
Human iPSC-derived MSCs (iMSCs) from aged individuals acquire a rejuvenation signature. / 18.03.2019 / PubMed / Full text
A null mutation in [i]SERPINE1[/i] protects against biological aging in humans. / 11.2017 / PubMed / Full text

SHE

Strong, healthy, energized: Striving for a healthy weight in an older lesbian population. / 05-06.2017 / PubMed / Full text
A mechanistic evaluation of the Syrian hamster embryo cell transformation assay (pH 6.7) and molecular events leading to senescence bypass in SHE cells. / 05.2016 / PubMed / Full text
Short-Term Buffers, but Long-Term Suffers? Differential Effects of Negative Self-Perceptions of Aging Following Serious Health Events. / 01.05.2017 / PubMed / Full text

SKP2

Nuclear AMPK regulated CARM1 stabilization impacts autophagy in aged heart. / 29.04.2017 / PubMed / Full text
14-3-3β Depletion Drives a Senescence Program in Glioblastoma Cells Through the ERK/SKP2/p27 Pathway. / 02.2018 / PubMed / Full text
Hyaluronan synthase 2 regulates fibroblast senescence in pulmonary fibrosis. / 09.2016 / PubMed / Full text

SMC3

Effects of Heyan Kuntai Capsule () on Follicular Development and Oocyte Cohesin Levels in Aged Mice. / 10.2018 / PubMed / Full text
The effect of DHEA on apoptosis and cohesin levels in oocytes in aged mice. / 12.09.2017 / PubMed / Full text
Elevated intracellular pH appears in aged oocytes and causes oocyte aneuploidy associated with the loss of cohesion in mice. / 16.09.2016 / PubMed / Full text

SMN1

Changing respiratory expectations with the new disease trajectory of nusinersen treated spinal muscular atrophy [SMA] type 1. / 09.2018 / PubMed / Full text
Type 0 Spinal Muscular Atrophy: Further Delineation of Prenatal and Postnatal Features in 16 Patients. / 29.11.2016 / PubMed / Full text
Systemic peptide-mediated oligonucleotide therapy improves long-term survival in spinal muscular atrophy. / 27.09.2016 / PubMed / Full text

SNAI1

MicroRNA-338-5p plays a tumor suppressor role in glioma through inhibition of the MAPK-signaling pathway by binding to FOXD1. / 12.2018 / PubMed / Full text
O-GlcNAcylation is required for mutant KRAS-induced lung tumorigenesis. / 01.11.2018 / PubMed / Full text
Upregulation of lactate-inducible snail protein suppresses oncogene-mediated senescence through p16 inactivation. / 26.02.2018 / PubMed / Full text

SOST

Low Serum Levels of DKK2 Predict Incident Low-Impact Fracture in Older Women. / 07.2019 / PubMed / Full text
Bone adaptation in response to treadmill exercise in young and adult mice. / 06.2018 / PubMed / Full text
WNT1-induced Secreted Protein-1 (WISP1), a Novel Regulator of Bone Turnover and Wnt Signaling. / 29.05.2015 / PubMed / Full text

SOX4

Age-induced accumulation of methylmalonic acid promotes tumour progression. / 09.2020 / PubMed / Full text
P4 medicine and osteoporosis: a systematic review. / 12.2016 / PubMed / Full text
Upregulation of SOX4 antagonizes cellular senescence in esophageal squamous cell carcinoma. / 08.2016 / PubMed / Full text

SPRTN

Tandem Deubiquitination and Acetylation of SPRTN Promotes DNA-Protein Crosslink Repair and Protects against Aging. / 03.09.2020 / PubMed / Full text
Metalloprotease SPRTN/DVC1 Orchestrates Replication-Coupled DNA-Protein Crosslink Repair. / 17.11.2016 / PubMed / Full text
SPRTN is a mammalian DNA-binding metalloprotease that resolves DNA-protein crosslinks. / 17.11.2016 / PubMed / Full text

SRI

The Role of Aging, Drug Dependence, and Hepatitis C Comorbidity in Alcoholism Cortical Compromise. / 01.05.2018 / PubMed / Full text
Fluoxetine induces input-specific hippocampal dendritic spine remodeling along the septotemporal axis in adulthood and middle age. / 11.2015 / PubMed / Full text
Role of the serotonin transporter gene locus in the response to SSRI treatment of major depressive disorder in late life. / 05.2015 / PubMed / Full text

STAC

Obesity and Aging: Consequences for Cognition, Brain Structure, and Brain Function. / 07-08.2015 / PubMed / Full text
Genetic risk for Alzheimer's disease alters the five-year trajectory of semantic memory activation in cognitively intact elders. / 01.05.2015 / PubMed / Full text
How does it STAC up? Revisiting the scaffolding theory of aging and cognition. / 09.2014 / PubMed / Full text

STAT6

IL4/STAT6 Signaling Activates Neural Stem Cell Proliferation and Neurogenesis upon Amyloid-β42 Aggregation in Adult Zebrafish Brain. / 18.10.2016 / PubMed / Full text
STAT6 inhibitory peptide given during RSV infection of neonatal mice reduces exacerbated airway responses upon adult reinfection. / 02.2017 / PubMed / Full text
The role of STAT transcription factors in apoptosis regulation of hypothalamic neurons in aging in HER-2/neu transgenic mice and wild-type FVB/N mice. / 05.2016 / PubMed / Full text

STIM1

Progerin in muscle leads to thermogenic and metabolic defects via impaired calcium homeostasis. / 02.2020 / PubMed / Full text
Ca entry via TRPC1 is essential for cellular differentiation and modulates secretion via the SNARE complex. / 01.07.2019 / PubMed / Full text
Calcium Dynamics of Ex Vivo Long-Term Cultured CD8 T Cells Are Regulated by Changes in Redox Metabolism. / 2016 / PubMed / Full text

SYK

miR-25-3p promotes endothelial cell angiogenesis in aging mice via TULA-2/SYK/VEGFR-2 downregulation. / 17.11.2020 / PubMed / Full text
Identification of SYK inhibitor, R406 as a novel senolytic agent. / 07.05.2020 / PubMed / Full text
Integrative Analysis of Hippocampus Gene Expression Profiles Identifies Network Alterations in Aging and Alzheimer's Disease. / 2018 / PubMed / Full text

SYP

The neuropeptide-12 improves recognition memory and neuronal plasticity of the limbic system in old rats. / 08.2018 / PubMed / Full text
Aging alters the molecular dynamics of synapses in a sexually dimorphic pattern in zebrafish (Danio rerio). / 06.2017 / PubMed / Full text
The reciprocal links between synaptophysin serum levels and the prevalence of metabolic syndrome according to selected low-grade inflammation indices and age-related androgen serum level changes in men. / 01.2016 / PubMed

TAS2R38

TAS2R38 bitter taste receptor and attainment of exceptional longevity. / 02.12.2019 / PubMed / Full text
Bitter, Sweet, Salty, Sour and Umami Taste Perception Decreases with Age: Sex-Specific Analysis, Modulation by Genetic Variants and Taste-Preference Associations in 18 to 80 Year-Old Subjects. / 18.10.2018 / PubMed / Full text
Age-related differences in bitter taste and efficacy of bitter blockers. / 2014 / PubMed / Full text

TES

The Effects of Electrical Stimulation Pulse Duration on Lingual Palatal Pressure Measures During Swallowing in Healthy Older Adults. / 08.2019 / PubMed / Full text
Comparison of different extenders on the recovery and longevity of epididymal sperm from Spix's yellow-toothed cavies (Galea spixii Wagler, 1831). / 04.2017 / PubMed / Full text
Aging Affects Identification of Vocal Emotions in Semantically Neutral Sentences. / 06.2015 / PubMed / Full text

TET3

Age-related Changes in the Global DNA Methylation Profile of Oligodendrocyte Progenitor Cells Derived from Rat Spinal Cords. / 02.2019 / PubMed / Full text
Dynamic changes in DNA demethylation in the tree shrew ([i]Tupaia belangeri chinensis[/i]) brain during postnatal development and aging. / 18.03.2017 / PubMed / Full text
5-azacytidine improves the osteogenic differentiation potential of aged human adipose-derived mesenchymal stem cells by DNA demethylation. / 2014 / PubMed / Full text

TGFB1

Proteomic Alterations Associated with Biomechanical Dysfunction are Early Processes in the Emilin1 Deficient Mouse Model of Aortic Valve Disease. / 11.2017 / PubMed / Full text
Seminal plasma transforming growth factor-β, activin A and follistatin fluctuate within men over time. / 10.2016 / PubMed / Full text
No Association between Variation in Longevity Candidate Genes and Aging-related Phenotypes in Oldest-old Danes. / 06.2016 / PubMed / Full text

THRB

Age-associated increase of thyroid hormone receptor β gene promoter methylation coexists with decreased gene expression. / 11.2018 / PubMed / Full text
Genome-wide association study for lactation persistency, female fertility, longevity, and lifetime profit index traits in Holstein dairy cattle. / 02.2017 / PubMed / Full text
The thyroid hormone receptor β induces DNA damage and premature senescence. / 06.01.2014 / PubMed / Full text

TLR5

Neonatal selection by Toll-like receptor 5 influences long-term gut microbiota composition. / 08.2018 / PubMed / Full text
Direct Regulation of TLR5 Expression by Caveolin-1. / 12.2015 / PubMed / Full text
Flagellin-dependent TLR5/caveolin-1 as a promising immune activator in immunosenescence. / 10.2015 / PubMed / Full text

TNC

Effects of Tenascin C on the Integrity of Extracellular Matrix and Skin Aging. / 18.11.2020 / PubMed / Full text
Tenascin-C expression controls the maturation of articular cartilage in mice. / 17.02.2020 / PubMed / Full text
Effects of hydrothermal aging, thermal cycling, and water storage on the mechanical properties of a machinable resin-based composite containing nano-zirconia fillers. / 02.2020 / PubMed / Full text

TPH1

[i]Lactobacillus plantarum[/i] DR7 improved brain health in aging rats via the serotonin, inflammatory and apoptosis pathways. / 02.12.2020 / PubMed / Full text
Ageing and gastrointestinal sensory function: altered colonic mechanosensory and chemosensory function in the aged mouse. / 15.08.2016 / PubMed / Full text
Use of the RatLoft decreases pup mortality in lactating mice. / 10.2016 / PubMed / Full text

TRAF3

TRAF3, a Target of MicroRNA-363-3p, Suppresses Senescence and Regulates the Balance Between Osteoblastic and Adipocytic Differentiation of Rat Bone Marrow-Derived Mesenchymal Stem Cells. / 01.06.2020 / PubMed / Full text
TGFβ-induced degradation of TRAF3 in mesenchymal progenitor cells causes age-related osteoporosis. / 26.06.2019 / PubMed / Full text
Aging impairs both primary and secondary RIG-I signaling for interferon induction in human monocytes. / 12.12.2017 / PubMed / Full text

TRAP1

Lifelong Football Training: Effects on Autophagy and Healthy Longevity Promotion. / 2019 / PubMed / Full text
Changes in Drosophila mitochondrial proteins following chaperone-mediated lifespan extension confirm a role of Hsp22 in mitochondrial UPR and reveal a mitochondrial localization for cathepsin D. / 04.2016 / PubMed / Full text
Mitochondrial chaperone TRAP1 activates the mitochondrial UPR and extends healthspan in Drosophila. / 11-12.2014 / PubMed / Full text

TRPC4

Alterations of store-operated calcium entry and cyclopiazonic acid-induced endothelium-derived relaxations in aging rat thoracic aorta. / 01.06.2016 / PubMed / Full text
Benzimidazole derivative M084 extends the lifespan of Caenorhabditis elegans in a DAF-16/FOXO-dependent way. / 02.2017 / PubMed / Full text
Cell senescence abrogates the therapeutic potential of human mesenchymal stem cells in the lethal endotoxemia model. / 07.2014 / PubMed / Full text

TRPV5

Changes in expression of klotho affect physiological processes, diseases, and cancer. / 01.2018 / PubMed / Full text
Lifelong challenge of calcium homeostasis in male mice lacking TRPV5 leads to changes in bone and calcium metabolism. / 03.05.2016 / PubMed / Full text
Molecular aspects of intestinal calcium absorption. / 21.06.2015 / PubMed / Full text

TUBB3

Evaluation of tubulin β-3 as a novel senescence-associated gene in melanocytic malignant transformation. / 03.2017 / PubMed / Full text
Autophagic homeostasis is required for the pluripotency of cancer stem cells. / 02.2017 / PubMed / Full text
GBM-associated mutations and altered protein expression are more common in young patients. / 25.10.2016 / PubMed / Full text

TXNRD2

Wogonin induces cellular senescence in breast cancer via suppressing TXNRD2 expression. / 10.2020 / PubMed / Full text
Loss of IDH2 Accelerates Age-related Hearing Loss in Male Mice. / 22.03.2018 / PubMed / Full text
Mitochondrial thioredoxin reductase 2 is elevated in long-lived primate as well as rodent species and extends fly mean lifespan. / 08.2017 / PubMed / Full text

TYROBP

TREM2 triggers microglial density and age-related neuronal loss. / 03.2019 / PubMed / Full text
Identification of a conserved gene signature associated with an exacerbated inflammatory environment in the hippocampus of aging rats. / 04.2017 / PubMed / Full text
Phenotypic characteristics of aged CD4 CD28 T lymphocytes are determined by changes in the whole-genome DNA methylation pattern. / 04.2017 / PubMed / Full text

UBE3A

Delayed loss of UBE3A reduces the expression of Angelman syndrome-associated phenotypes. / 2019 / PubMed / Full text
Seizure-like activity in a juvenile Angelman syndrome mouse model is attenuated by reducing Arc expression. / 21.04.2015 / PubMed / Full text
Exercise-associated DNA methylation change in skeletal muscle and the importance of imprinted genes: a bioinformatics meta-analysis. / 12.2015 / PubMed / Full text

UHRF1

MLL3 promotes the senescence of esophageal squamous cell carcinoma. / 2019 / PubMed / Full text
UHRF1 is required for basal stem cell proliferation in response to airway injury. / 2017 / PubMed / Full text
The Ubiquitin-like with PHD and Ring Finger Domains 1 (UHRF1)/DNA Methyltransferase 1 (DNMT1) Axis Is a Primary Regulator of Cell Senescence. / 03.03.2017 / PubMed / Full text

USP7

Deubiquitinase USP7 regulates [i]Drosophila[/i] aging through ubiquitination and autophagy. / 20.11.2020 / PubMed / Full text
Disruption of the Phosphate Transporter Pit1 in Hepatocytes Improves Glucose Metabolism and Insulin Signaling by Modulating the USP7/IRS1 Interaction. / 06.09.2016 / PubMed / Full text
The C. elegans Ortholog of USP7 controls DAF-16 stability in Insulin/IGF-1-like signaling. / 10-12.2015 / PubMed / Full text

WLS

Evaluation of three statistical prediction models for forensic age prediction based on DNA methylation. / 05.2018 / PubMed / Full text
The Influence of Social Conditions Across the Life Course on the Human Gut Microbiota: A Pilot Project With the Wisconsin Longitudinal Study. / 15.12.2017 / PubMed / Full text
Targeted sequencing of genome wide significant loci associated with bone mineral density (BMD) reveals significant novel and rare variants: the Cohorts for Heart and Aging Research in Genomic Epidemiology (CHARGE) targeted sequencing study. / 01.12.2016 / PubMed / Full text

WNT3A

Chronic WNT/β-catenin signaling induces cellular senescence in lung epithelial cells. / 06.2020 / PubMed / Full text
WNT3A accelerates delayed alveolar bone repair in ovariectomized mice. / 09.2019 / PubMed / Full text
WNT-activated bone grafts repair osteonecrotic lesions in aged animals. / 27.10.2017 / PubMed / Full text

WT1

Age and weight at first mating affects plasma leptin concentration but no effects on reproductive performance of gilts. / 09.2019 / PubMed / Full text
Epigenetic Aging Signatures Are Coherently Modified in Cancer. / 06.2015 / PubMed / Full text
A novel cell-penetrating peptide derived from WT1 enhances p53 activity, induces cell senescence and displays antimelanoma activity in xeno- and syngeneic systems. / 2014 / PubMed / Full text

XRCC3

Lifespan and Stress Resistance in Drosophila with Overexpressed DNA Repair Genes. / 19.10.2015 / PubMed / Full text
Subclinical carotid atherosclerosis and early vascular aging from long-term low-dose ionizing radiation exposure: a genetic, telomere, and vascular ultrasound study in cardiac catheterization laboratory staff. / 20.04.2015 / PubMed / Full text
[Role of DNA repair genes in radiation-induced changes of lifespan of Drosophila melanogaster]. / 09-10.2014 / PubMed

ZCWPW1

Late Onset Alzheimer's Disease Risk Variants in Cognitive Decline: The PATH Through Life Study. / 2017 / PubMed / Full text
Association and interaction effects of Alzheimer's disease-associated genes and lifestyle on cognitive aging in older adults in a Taiwanese population. / 11.04.2017 / PubMed / Full text
Gene-based aggregate SNP associations between candidate AD genes and cognitive decline. / 04.2016 / PubMed / Full text