Aging genes 1-2

AACS

Sex differences in subjective age-associated changes in sleep: a prospective elderly cohort study. / 07.11.2020 / PubMed / Full text
Extended Multiplexing of Tandem Mass Tags (TMT) Labeling Reveals Age and High Fat Diet Specific Proteome Changes in Mouse Epididymal Adipose Tissue. / 05.2017 / PubMed / Full text

ABCC2

Proteomic Analysis of the Developmental Trajectory of Human Hepatic Membrane Transporter Proteins in the First Three Months of Life. / 07.2016 / PubMed / Full text
Developmental characteristics of urinary coproporphyrin I/(I III) ratio. / 10.2016 / PubMed / Full text

ABCC6

[i]ABCC6[/i] knockdown in HepG2 cells induces a senescent-like cell phenotype. / 2017 / PubMed / Full text
Changes in dermal fibroblasts from Abcc6(-/-) mice are present before and after the onset of ectopic tissue mineralization. / 07.2014 / PubMed / Full text

ABI3

Arabidopsis seed-specific vacuolar aquaporins are involved in maintaining seed longevity under the control of ABSCISIC ACID INSENSITIVE 3. / 08.2015 / PubMed / Full text
A forward genetic approach in Arabidopsis thaliana identifies a RING-type ubiquitin ligase as a novel determinant of seed longevity. / 02.2014 / PubMed / Full text

ACACA

Expression of lipogenic markers is decreased in subcutaneous adipose tissue and adipocytes of older women and is negatively linked to GDF15 expression. / 08.2019 / PubMed / Full text
GH prevents adipogenic differentiation of mesenchymal stromal stem cells derived from human trabecular bone via canonical Wnt signaling. / 07.2018 / PubMed / Full text

ACAN

MicroRNA-143-5p targeting eEF2 gene mediates intervertebral disc degeneration through the AMPK signaling pathway. / 15.04.2019 / PubMed / Full text
Acetylation reduces SOX9 nuclear entry and ACAN gene transactivation in human chondrocytes. / 06.2016 / PubMed / Full text

ACTA1

Explaining meat quality of bulls and steers by differential proteome and phosphoproteome analysis of skeletal muscle. / 15.05.2019 / PubMed / Full text
Serum starvation of ARPE-19 changes the cellular distribution of cholesterol and Fibulin3 in patterns reminiscent of age-related macular degeneration. / 15.12.2017 / PubMed / Full text

ACTB

Selection of a Real-Time PCR Housekeeping Gene Panel in Human Endothelial Colony Forming Cells for Cellular Senescence Studies. / 2019 / PubMed / Full text
WNT-activated bone grafts repair osteonecrotic lesions in aged animals. / 27.10.2017 / PubMed / Full text

ACVR1

Fibrodysplasia Ossificans Progressiva (FOP): A Segmental Progeroid Syndrome. / 2019 / PubMed / Full text
BMP-SMAD-ID promotes reprogramming to pluripotency by inhibiting p16/INK4A-dependent senescence. / 15.11.2016 / PubMed / Full text

ADH1B

Telomere shortening in alcohol dependence: Roles of alcohol and acetaldehyde. / 02.2019 / PubMed / Full text
Relationships of alcohol dehydrogenase 1B (ADH1B) and aldehyde dehydrogenase 2 (ALDH2) genotypes with alcohol sensitivity, drinking behavior and problem drinking in Japanese older men. / 05.2016 / PubMed / Full text

ADH5

Can Serum Nitrosoproteome Predict Longevity of Aged Women? / 27.11.2020 / PubMed / Full text
Denitrosylate and live longer: how ADH5/GSNOR links mitophagy to aging. / 2018 / PubMed / Full text

ADIPOQ

Determination of the Mechanisms that Cause Sarcopenia through cDNA Microarray. / 2017 / PubMed / Full text
Contribution of adiponectin and its type 1 receptor to age-related hearing impairment. / 06.2015 / PubMed / Full text

ADIPOR1

A Novel [i]Dnmt3a1[/i] Transcript Inhibits Adipogenesis. / 2018 / PubMed / Full text
Contribution of adiponectin and its type 1 receptor to age-related hearing impairment. / 06.2015 / PubMed / Full text

ADNP

ADNP differentially interact with genes/proteins in correlation with aging: a novel marker for muscle aging. / 06.2019 / PubMed / Full text
ADNP: A major autism mutated gene is differentially distributed (age and gender) in the songbird brain. / 10.2015 / PubMed / Full text

ADRA2B

Aging and the Combined effects of ADRA2B and CB1 deletions on Affective Working Memory. / 11.03.2019 / PubMed / Full text
Aging and the genetic road towards the positivity effect in memory. / 09.2016 / PubMed / Full text

AGER

Vitamin D3 regulates apoptosis and proliferation in the testis of D-galactose-induced aged rat model. / 01.10.2019 / PubMed / Full text
Long-lived rodents reveal signatures of positive selection in genes associated with lifespan. / 03.2018 / PubMed / Full text

AGO2

Profiling of m6A RNA modifications identified an age-associated regulation of AGO2 mRNA stability. / 06.2018 / PubMed / Full text
miRNA processing gene polymorphisms, blood DNA methylation age and long-term ambient PM exposure in elderly men. / 12.2017 / PubMed / Full text

AHCY

Towards frailty biomarkers: Candidates from genes and pathways regulated in aging and age-related diseases. / 11.2018 / PubMed / Full text
Tissue-specific down-regulation of S-adenosyl-homocysteine via suppression of dAhcyL1/dAhcyL2 extends health span and life span in Drosophila. / 15.06.2016 / PubMed / Full text

AIDA

Identification of Postharvest Senescence Regulators Through Map-Based Cloning Using Detached Arabidopsis Inflorescences as a Model Tissue. / 2018 / PubMed / Full text
Interaction of DHPG-LTD and synaptic-LTD at senescent CA3-CA1 hippocampal synapses. / 04.2014 / PubMed / Full text

AKT3

Oxidative stress-induced miRNAs modulate AKT signaling and promote cellular senescence in uterine leiomyoma. / 10.2018 / PubMed / Full text
MicroRNA-22 induces endothelial progenitor cell senescence by targeting AKT3. / 2014 / PubMed / Full text

AKTIP

Mice with reduced expression of the telomere-associated protein Ft1 develop p53-sensitive progeroid traits. / 08.2018 / PubMed / Full text
The telomeric protein AKTIP interacts with A- and B-type lamins and is involved in regulation of cellular senescence. / 08.2016 / PubMed / Full text

ALKBH8

Loss of epitranscriptomic control of selenocysteine utilization engages senescence and mitochondrial reprogramming . / 01.2020 / PubMed / Full text
ALKB-8, a 2-Oxoglutarate-Dependent Dioxygenase and S-Adenosine Methionine-Dependent Methyltransferase Modulates Metabolic Events Linked to Lysosome-Related Organelles and Aging in C. elegans. / 2018 / PubMed

ANGPTL2

Circulating angiopoietin-like protein 2 levels and mortality risk in patients receiving maintenance hemodialysis: a prospective cohort study. / 01.05.2020 / PubMed / Full text
Age-dependent increase in angiopoietin-like protein 2 accelerates skeletal muscle loss in mice. / 02.02.2018 / PubMed / Full text

ANK1

Alzheimer's Disease Associated Genes Ankyrin and Tau Cause Shortened Lifespan and Memory Loss in [i]Drosophila[/i]. / 2019 / PubMed / Full text
DNA methylation analysis on purified neurons and glia dissects age and Alzheimer's disease-specific changes in the human cortex. / 25.07.2018 / PubMed / Full text

ANK3

Age-related atrophy of cortical thickness and genetic effect of ANK3 gene in first episode MDD patients. / 26.08.2020 / PubMed / Full text
Mood, stress and longevity: convergence on ANK3. / 08.2016 / PubMed / Full text

AP2B1

Circular RNA NF1-419 enhances autophagy to ameliorate senile dementia by binding Dynamin-1 and Adaptor protein 2 B1 in AD-like mice. / 20.12.2019 / PubMed / Full text
Investigating the specific core genetic-and-epigenetic networks of cellular mechanisms involved in human aging in peripheral blood mononuclear cells. / 23.02.2016 / PubMed / Full text

APOB

Autophagy-mediated longevity is modulated by lipoprotein biogenesis. / 2016 / PubMed / Full text
Exome sequencing of three cases of familial exceptional longevity. / 12.2014 / PubMed / Full text

APOL1

APOL1 Risk Alleles Are Associated with Exaggerated Age-Related Changes in Glomerular Number and Volume in African-American Adults: An Autopsy Study. / 12.2015 / PubMed / Full text
Apolipoprotein L1, income and early kidney damage. / 10.02.2015 / PubMed / Full text

APPL2

The reversal effect of physical exercise on aging-related increases in APPL2 content in skeletal muscle. / 01.10.2018 / PubMed / Full text
Adaptor Protein APPL2 Affects Adult Antidepressant Behaviors and Hippocampal Neurogenesis via Regulating the Sensitivity of Glucocorticoid Receptor. / 07.2018 / PubMed / Full text

AQP3

Transbuccal platform for delivery of lipogenic actives to facial skin: Because fat matters. / 08.2020 / PubMed / Full text
[Age-related changes of water transport by corneal endothelial cells in rats.] / 2017 / PubMed

ARID1B

A 69-year-old woman with Coffin-Siris syndrome. / 08.2018 / PubMed / Full text
SWI/SNF regulates a transcriptional program that induces senescence to prevent liver cancer. / 01.10.2016 / PubMed / Full text

ARX

Converting Adult Pancreatic Islet α Cells into β Cells by Targeting Both Dnmt1 and Arx. / 07.03.2017 / PubMed / Full text
Acacetin 7-O-α-l-rhamnopyranosyl (1-2) β-D-xylopyranoside Elicits Life-span Extension and Stress Resistance in Caenorhabditis elegans. / 09.2016 / PubMed / Full text

ASXL2

Genomewide meta-analysis identifies loci associated with IGF-I and IGFBP-3 levels with impact on age-related traits. / 10.2016 / PubMed / Full text
The BAP1/ASXL2 Histone H2A Deubiquitinase Complex Regulates Cell Proliferation and Is Disrupted in Cancer. / 27.11.2015 / PubMed / Full text

ATF2

Transcriptional regulation of stress kinase JNK2 in pro-arrhythmic CaMKIIδ expression in the aged atrium. / 01.04.2018 / PubMed / Full text
Prmt7 Deficiency Causes Reduced Skeletal Muscle Oxidative Metabolism and Age-Related Obesity. / 07.2016 / PubMed / Full text

ATF7

Stress-induced and ATF7-dependent epigenetic change influences cellular senescence. / 09.2019 / PubMed / Full text
Identification of ATF-7 and the insulin signaling pathway in the regulation of metallothionein in C. elegans suggests roles in aging and reactive oxygen species. / 2017 / PubMed / Full text

ATG9A

SIRT1 protects cochlear hair cell and delays age-related hearing loss via autophagy. / 08.2019 / PubMed / Full text
Activation of miR-34a impairs autophagic flux and promotes cochlear cell death via repressing ATG9A: implications for age-related hearing loss. / 05.10.2017 / PubMed / Full text

ATP1A2

SerThr-PhosphoProteome of Brain from Aged PINK1-KO A53T-SNCA Mice Reveals pT1928-MAP1B and pS3781-ANK2 Deficits, as Hub between Autophagy and Synapse Changes. / 04.07.2019 / PubMed / Full text
The Influence of Na( ), K( )-ATPase on Glutamate Signaling in Neurodegenerative Diseases and Senescence. / 2016 / PubMed / Full text

ATP6V1E1

Low expression of aging-related [[NRXN3]] is associated with Alzheimer disease: A systematic review and meta-analysis. / 07.2018 / PubMed / Full text
Chemical screening identifies ATM as a target for alleviating senescence. / 06.2017 / PubMed / Full text

ATP7A

Adipocyte-specific disruption of ATPase copper transporting α in mice accelerates lipoatrophy. / 12.2019 / PubMed / Full text
TAp73 regulates ATP7A: possible implications for ageing-related diseases. / 08.12.2018 / PubMed / Full text

AXL

Extracellular acidosis triggers a senescence-like phenotype in human melanoma cells. / 01.2020 / PubMed / Full text
CSF protein changes associated with hippocampal sclerosis risk gene variants highlight impact of GRN/PGRN. / 04.2017 / PubMed / Full text

B4GALT1

Expression of β-1,4-galactosyltransferases during Aging in Caenorhabditis elegans. / 2020 / PubMed / Full text
Glycobiology of Aging. / 2018 / PubMed / Full text

BAG3

Nrf2 mediates the expression of BAG3 and autophagy cargo adaptor proteins and tau clearance in an age-dependent manner. / 03.2018 / PubMed / Full text
Age-related obesity and type 2 diabetes dysregulate neuronal associated genes and proteins in humans. / 06.10.2015 / PubMed / Full text

BANF1

An additional case of Néstor-Guillermo progeria syndrome diagnosed in early childhood. / 10.2020 / PubMed / Full text
Néstor-Guillermo Progeria Syndrome: a biochemical insight into Barrier-to-Autointegration Factor 1, alanine 12 threonine mutation. / 12.12.2014 / PubMed / Full text

BARD1

BRCA1 and BARD1 mediate apoptotic resistance but not longevity upon mitochondrial stress in [i]Caenorhabditis elegans[/i]. / 12.2018 / PubMed / Full text
The Histone Variant MacroH2A1 Is a BRCA1 Ubiquitin Ligase Substrate. / 30.05.2017 / PubMed / Full text

BCL11B

Responders and non-responders to influenza vaccination: A DNA methylation approach on blood cells. / 05.2018 / PubMed / Full text
Age-related profiling of DNA methylation in CD8 T cells reveals changes in immune response and transcriptional regulator genes. / 19.08.2015 / PubMed / Full text

BCL6

Ecto-NTPDase CD39 is a negative checkpoint that inhibits follicular helper cell generation. / 01.07.2020 / PubMed / Full text
Transcription factor networks in aged naïve CD4 T cells bias lineage differentiation. / 08.2019 / PubMed / Full text

BMPR1B

Growth hormone during in vitro fertilization in older women modulates the density of receptors in granulosa cells, with improved pregnancy outcomes. / 12.2018 / PubMed / Full text
Dysregulation of granulosal bone morphogenetic protein receptor 1B density is associated with reduced ovarian reserve and the age-related decline in human fertility. / 15.04.2016 / PubMed / Full text

BRD2

Brd2 haploinsufficiency extends lifespan and healthspan in C57B6/J mice. / 2020 / PubMed / Full text
Genetic architecture differences between pediatric and adult-onset inflammatory bowel diseases in the Polish population. / 23.12.2016 / PubMed / Full text

BTC

Behavioral tagging and capture: long-term memory decline in middle-aged rats. / 07.2018 / PubMed / Full text
Estimates of genetic parameters for content of boar taint compounds in adipose tissue of intact males at 160 and 220 days of age. / 09.2015 / PubMed / Full text

BTK

Amelioration of age-related brain function decline by Bruton's tyrosine kinase inhibition. / 01.2020 / PubMed / Full text
BTK suppresses myeloma cellular senescence through activating AKT/P27/Rb signaling. / 22.08.2017 / PubMed / Full text

BTLA

Combinatorial approach to cancer immunotherapy: strength in numbers. / 08.2016 / PubMed / Full text
BTLA expression declines on B cells of the aged and is associated with low responsiveness to the trivalent influenza vaccine. / 14.08.2015 / PubMed / Full text

CA12

Co-culturing nucleus pulposus mesenchymal stem cells with notochordal cell-rich nucleus pulposus explants attenuates tumor necrosis factor-α-induced senescence. / 26.06.2018 / PubMed / Full text
Notochordal and nucleus pulposus marker expression is maintained by sub-populations of adult human nucleus pulposus cells through aging and degeneration. / 04.05.2017 / PubMed / Full text

CASK

Integrated study on comparative transcriptome and skeletal muscle function in aged rats. / 01.2018 / PubMed / Full text
Neurexins 1-3 Each Have a Distinct Pattern of Expression in the Early Developing Human Cerebral Cortex. / 01.01.2017 / PubMed / Full text

CAST

Cytomatrix proteins CAST and ELKS regulate retinal photoreceptor development and maintenance. / 05.11.2018 / PubMed / Full text
Short Telomeres Induce p53 and Autophagy and Modulate Age-Associated Changes in Cardiac Progenitor Cell Fate. / 06.2018 / PubMed / Full text

CBX7

Integrin Beta 3 Regulates Cellular Senescence by Activating the TGF-β Pathway. / 07.03.2017 / PubMed / Full text
CBX7 and miR-9 are part of an autoregulatory loop controlling p16(INK) (4a). / 12.2015 / PubMed / Full text

CBX8

PIM1-catalyzed CBX8 phosphorylation promotes the oncogene-induced senescence of human diploid fibroblast. / 27.06.2018 / PubMed / Full text
CBX8 antagonizes the effect of Sirtinol on premature senescence through the AKT-RB-E2F1 pathway in K562 leukemia cells. / 22.01.2016 / PubMed / Full text

CCL13

Age-specific changes in the molecular phenotype of patients with moderate-to-severe atopic dermatitis. / 07.2019 / PubMed / Full text
Differential Gene Expression Profiles Reflecting Macrophage Polarization in Aging and Periodontitis Gingival Tissues. / 2015 / PubMed / Full text

CCL17

Aging and chronic high-fat feeding negatively affects kidney size, function, and gene expression in CTRP1-deficient mice. / 21.10.2020 / PubMed / Full text
Senescent thyrocytes and thyroid tumor cells induce M2-like macrophage polarization of human monocytes via a PGE2-dependent mechanism. / 21.05.2019 / PubMed / Full text

CCL24

Regulatory T-cells regulate neonatal heart regeneration by potentiating cardiomyocyte proliferation in a paracrine manner. / 2019 / PubMed / Full text
Anserine/Carnosine Supplementation Suppresses the Expression of the Inflammatory Chemokine CCL24 in Peripheral Blood Mononuclear Cells from Elderly People. / 31.10.2017 / PubMed / Full text

CCN2

CCN2 induces cellular senescence in fibroblasts. / 03.2017 / PubMed / Full text
Generation and Analysis of Cartilage-Specific CCN2 Overexpression in Transgenic Mice. / 2017 / PubMed / Full text

CCN4

CCN proteins as potential actionable targets in scleroderma. / 01.2019 / PubMed / Full text
WNT1-induced Secreted Protein-1 (WISP1), a Novel Regulator of Bone Turnover and Wnt Signaling. / 29.05.2015 / PubMed / Full text

CCND1

Effects of hydrogen peroxide, doxorubicin and ultraviolet irradiation on senescence of human dental pulp stem cells. / 09.2020 / PubMed / Full text
Expansion of adipose tissue-derived stromal cells at "physiologic" hypoxia attenuates replicative senescence. / 06.2017 / PubMed / Full text

CCNG2

A Novel [i]Dnmt3a1[/i] Transcript Inhibits Adipogenesis. / 2018 / PubMed / Full text
Hypoxia-inducible transcription factors, HIF1A and HIF2A, increase in aging mucosal tissues. / 07.2018 / PubMed / Full text

CD160

Age-related changes in the gene expression profile of antigen-specific mouse CD8 T cells can be partially reversed by blockade of the BTLA/CD160 pathways during vaccination. / 09.11.2016 / PubMed / Full text
T cells in multiple myeloma display features of exhaustion and senescence at the tumor site. / 03.11.2016 / PubMed / Full text

CD46

Soluble forms of CD46 are detected in Bos taurus plasma and neutralize BVDV, the bovine pestivirus. / 12.2016 / PubMed / Full text
Brain innate immunity in the regulation of neuroinflammation: therapeutic strategies by modulating CD200-CD200R interaction involve the cannabinoid system. / 2014 / PubMed / Full text

CDC25A

Babam2 Regulates Cell Cycle Progression and Pluripotency in Mouse Embryonic Stem Cells as Revealed by Induced DNA Damage. / 10.10.2020 / PubMed / Full text
Nickel-induced HIF-1α promotes growth arrest and senescence in normal human cells but lacks toxic effects in transformed cells. / 15.09.2017 / PubMed / Full text

CDH1

Cdc6 as a novel target in cancer: Oncogenic potential, senescence and subcellular localisation. / 15.09.2020 / PubMed / Full text
A Multigene Test Could Cost-Effectively Help Extend Life Expectancy for Women at Risk of Hereditary Breast Cancer. / 04.2017 / PubMed / Full text

CDKN1B

A Novel [i]Dnmt3a1[/i] Transcript Inhibits Adipogenesis. / 2018 / PubMed / Full text
RNA methyltransferase NSUN2 promotes stress-induced HUVEC senescence. / 12.04.2016 / PubMed / Full text

CDKN1C

Human iPSC-derived MSCs (iMSCs) from aged individuals acquire a rejuvenation signature. / 18.03.2019 / PubMed / Full text
Expansion of adipose tissue-derived stromal cells at "physiologic" hypoxia attenuates replicative senescence. / 06.2017 / PubMed / Full text

CDKN2B

Molecular Genetics and Functional Analysis Implicate [i]CDKN2BAS1-CDKN2B[/i] Involvement in POAG Pathogenesis. / 21.08.2020 / PubMed / Full text
Interference of the long noncoding RNA CDKN2B-AS1 upregulates miR-181a-5p/TGFβI axis to restrain the metastasis and promote apoptosis and senescence of cervical cancer cells. / 04.2019 / PubMed / Full text

CDR1

Two Distinct Pathways in Mice Generate Antinuclear Antigen-Reactive B Cell Repertoires. / 2018 / PubMed / Full text
Neuro-degeneration profile of Alzheimer's patients: A brain morphometry study. / 2017 / PubMed / Full text

CDX2

Maternal ageing impairs mitochondrial DNA kinetics during early embryogenesis in mice. / 08.07.2019 / PubMed / Full text
Autophagic homeostasis is required for the pluripotency of cancer stem cells. / 02.2017 / PubMed / Full text

CEBPB

Integrative Analysis of Hippocampus Gene Expression Profiles Identifies Network Alterations in Aging and Alzheimer's Disease. / 2018 / PubMed / Full text
The microRNA miR-17-3p inhibits mouse cardiac fibroblast senescence by targeting Par4. / 15.01.2015 / PubMed / Full text

CELF1

Association and interaction effects of Alzheimer's disease-associated genes and lifestyle on cognitive aging in older adults in a Taiwanese population. / 11.04.2017 / PubMed / Full text
Gene-based aggregate SNP associations between candidate AD genes and cognitive decline. / 04.2016 / PubMed / Full text

CES2

Age-Dependent Absolute Abundance of Hepatic Carboxylesterases (CES1 and CES2) by LC-MS/MS Proteomics: Application to PBPK Modeling of Oseltamivir In Vivo Pharmacokinetics in Infants. / 02.2017 / PubMed / Full text
Age-Dependent Human Hepatic Carboxylesterase 1 (CES1) and Carboxylesterase 2 (CES2) Postnatal Ontogeny. / 07.2016 / PubMed / Full text

CFD

Senescent dermal fibroblasts negatively influence fibroblast extracellular matrix-related gene expression partly via secretion of complement factor D. / 07.2019 / PubMed / Full text
New horizons in the compression of functional decline. / 01.11.2018 / PubMed / Full text

CFP

Proteopathic tau seeding predicts tauopathy in vivo. / 14.10.2014 / PubMed / Full text
Characterization of the IL-15 niche in primary and secondary lymphoid organs in vivo. / 04.02.2014 / PubMed / Full text

CHI3L1

Postsynaptic damage and microglial activation in AD patients could be linked CXCR4/CXCL12 expression levels. / 15.12.2020 / PubMed / Full text
Sex difference in CHI3L1 expression levels in human brain aging and in Alzheimer's disease. / 01.10.2019 / PubMed / Full text

CHIA

Lipoprotein Profile in Aged Rats Fed Chia Oil- or Hydroxytyrosol-Enriched Pork in High Cholesterol/High Saturated Fat Diets. / 26.11.2018 / PubMed / Full text
Chia Oil-Enriched Restructured Pork Effects on Oxidative and Inflammatory Status of Aged Rats Fed High Cholesterol/High Fat Diets. / 05.2017 / PubMed / Full text

CHL1

Close Homolog of L1 Regulates Dendritic Spine Density in the Mouse Cerebral Cortex Through Semaphorin 3B. / 07.08.2019 / PubMed / Full text
Age-dependent loss of parvalbumin-expressing hippocampal interneurons in mice deficient in CHL1, a mental retardation and schizophrenia susceptibility gene. / 11.2015 / PubMed / Full text

CHM

[Molecular regulative mechanisms of aging and interventional effects of Chinese herbal medicine]. / 08.2017 / PubMed / Full text
[Molecular mechanisms of autophagy in regulating renal aging and interventional effects of Chinese herbal medicine]. / 11.2016 / PubMed / Full text

CLC

Impact of Intervention to Improve Nursing Home Resident-Staff Interactions and Engagement. / 13.07.2018 / PubMed / Full text
Effect of cholesterol loaded cyclodextrin on semen cryopreservation of Aksaray Malakli shepherd dogs of different ages. / 06.2018 / PubMed / Full text

CLEC3B

CLEC3B p.S106G Mutant in a Caucasian Population of Successful Neurological Aging. / 16.09.2020 / PubMed / Full text
Exome-wide Association Study Identifies CLEC3B Missense Variant p.S106G as Being Associated With Extreme Longevity in East Asian Populations. / 01.03.2017 / PubMed / Full text

CLPP

Mitochondrial unfolded protein response: a stress response with implications for fertility and reproductive aging. / 02.2019 / PubMed / Full text
Mitochondrial unfolded protein response gene Clpp is required to maintain ovarian follicular reserve during aging, for oocyte competence, and development of pre-implantation embryos. / 08.2018 / PubMed / Full text

CNP

Environmental Enrichment Elicits a Transient Rise of Bioactive C-Type Natriuretic Peptide in Young but Not Aged Rats. / 2018 / PubMed / Full text
In aging, the vulnerability of rat brain mitochondria is enhanced due to reduced level of 2',3'-cyclic nucleotide-3'-phosphodiesterase (CNP) and subsequently increased permeability transition in brain mitochondria in old animals. / 01.2015 / PubMed / Full text

CNTF

Absence of axonal sprouting following unilateral lesion in 125-day-old rat supraoptic nucleus may be due to age-dependent decrease in protein levels of ciliary neurotrophic factor receptor alpha. / 01.10.2019 / PubMed / Full text
Maintenance of membrane organization in the aging mouse brain as the determining factor for preventing receptor dysfunction and for improving response to anti-Alzheimer treatments. / 06.2017 / PubMed / Full text

CNTNAP2

Selective molecular biomarkers to predict biologic behavior in pituitary tumors. / 05.2017 / PubMed / Full text
A common copy number variation polymorphism in the CNTNAP2 gene: sexual dimorphism in association with healthy aging and disease. / 2015 / PubMed / Full text

COL2A1

Inhibition of Wnt/β-catenin signaling ameliorates osteoarthritis in a murine model of experimental osteoarthritis. / 08.02.2018 / PubMed / Full text
Endoplasmic reticulum stress participates in the progress of senescence and apoptosis of osteoarthritis chondrocytes. / 16.09.2017 / PubMed / Full text

COPE

Patterns and characteristics of cognitive functioning in older patients approaching end stage kidney disease, the COPE-study. / 09.04.2020 / PubMed / Full text
Falls self-efficacy and falls incidence in community-dwelling older people: the mediating role of coping. / 05.2018 / PubMed / Full text

COQ7

Reduction in the levels of CoQ biosynthetic proteins is related to an increase in lifespan without evidence of hepatic mitohormesis. / 18.09.2018 / PubMed / Full text
Gene expression differences in relation to age and social environment in queen and worker bumble bees. / 05.2016 / PubMed / Full text

COX5B

Role of Mitochondrial Complex IV in Age-Dependent Obesity. / 13.09.2016 / PubMed / Full text
Loss of COX5B inhibits proliferation and promotes senescence via mitochondrial dysfunction in breast cancer. / 22.12.2015 / PubMed / Full text

CPQ

A Spanish Adaptation of the Computer and Mobile Device Proficiency Questionnaires (CPQ and MDPQ) for Older Adults. / 2019 / PubMed / Full text
Protective Effect of Semisynthetic and Natural Flavonoid on Aged Rat Microglia-enriched Cultures. / 11.2019 / PubMed / Full text

CPT1B

Effects of carnitine palmitoyltransferases on cancer cellular senescence. / 02.2019 / PubMed / Full text
Effect of testosterone on markers of mitochondrial oxidative phosphorylation and lipid metabolism in muscle of aging men with subnormal bioavailable testosterone. / 07.2014 / PubMed / Full text

CPT2

The phytochemical epigallocatechin gallate prolongs the lifespan by improving lipid metabolism, reducing inflammation and oxidative stress in high-fat diet-fed obese rats. / 09.2020 / PubMed / Full text
Glial β-oxidation regulates Drosophila energy metabolism. / 15.01.2015 / PubMed / Full text

CR2

Age-related but not longevity-related genes are found by weighted gene co-expression network analysis in the peripheral blood cells of humans. / 19.01.2019 / PubMed / Full text
Senescent dermal fibroblasts enhance stem cell migration through CCL2/CCR2 axis. / 07.2015 / PubMed / Full text

CRABP2

Preconception resveratrol intake against infertility: Friend or foe? / 04.2020 / PubMed / Full text
Cross platform analysis of transcriptomic data identifies ageing has distinct and opposite effects on tendon in males and females. / 31.10.2017 / PubMed / Full text

CREB5

Cellular senescence induces replication stress with almost no affect on DNA replication timing. / 2018 / PubMed / Full text
Transcriptomic and epigenetic analyses reveal a gender difference in aging-associated inflammation: the Vitality 90 study. / 08.2015 / PubMed / Full text

CREBBP

Systems biology and network pharmacology of frailty reveal novel epigenetic targets and mechanisms. / 22.07.2019 / PubMed / Full text
Genetic variants in a 'cAMP element binding protein' (CREB)-dependent histone acetylation pathway influence memory performance in cognitively healthy elderly individuals. / 12.2014 / PubMed / Full text

CREM

Ageing in men with normal spermatogenesis alters spermatogonial dynamics and nuclear morphology in Sertoli cells. / 11.2019 / PubMed / Full text
Constitutive Expression of Inducible Cyclic Adenosine Monophosphate Early Repressor (ICER) in Cycling Quiescent Hematopoietic Cells: Implications for Aging Hematopoietic Stem Cells. / 02.2017 / PubMed / Full text

CRYAB

Binding of a glaucoma-associated myocilin variant to the αB-crystallin chaperone impedes protein clearance in trabecular meshwork cells. / 28.12.2018 / PubMed / Full text
Quantitative proteomics analysis by iTRAQ in human nuclear cataracts of different ages and normal lens nuclei. / 08.2015 / PubMed / Full text

CSRP1

FOXO3, a Molecular Search for the Fountain of Youth. / 07.03.2019 / PubMed / Full text
FOXO3-Engineered Human ESC-Derived Vascular Cells Promote Vascular Protection and Regeneration. / 07.03.2019 / PubMed / Full text

CTSL

Cathepsin L deficiency results in reactive oxygen species (ROS) accumulation and vascular cells activation. / 12.2017 / PubMed / Full text
Involvement of lysosomal dysfunction in autophagosome accumulation and early pathologies in adipose tissue of obese mice. / 03.04.2017 / PubMed / Full text

CYB5A

11-Oxygenated C19 Steroids Do Not Decline With Age in Women. / 01.07.2019 / PubMed / Full text
3βHSD and CYB5A double positive adrenocortical cells during adrenal development/aging. / 2015 / PubMed / Full text

CYP11B2

Expression of aldosterone synthase CYP11B2 was inversely correlated with longevity. / 07.2019 / PubMed / Full text
Age-Related Autonomous Aldosteronism. / 25.07.2017 / PubMed / Full text

CYP24A1

Oleanolic Acid Exerts Osteoprotective Effects and Modulates Vitamin D Metabolism. / 22.02.2018 / PubMed / Full text
Environmental and genetic determinants of vitamin D status among older adults in London, UK. / 11.2016 / PubMed / Full text

CYP27A1

Prenatal betaine exposure alleviates corticosterone-induced inhibition of CYP27A1 expression in the liver of juvenile chickens associated with its promoter DNA methylation. / 15.05.2017 / PubMed / Full text
Synergic hypocholesterolaemic effect of n-3 PUFA and oestrogen by modulation of hepatic cholesterol metabolism in female rats. / 14.12.2015 / PubMed / Full text

CYP2A6

Analysis of the variability of the pharmacokinetics of multiple drugs in young adult and elderly subjects and its implications for acceptable daily exposures and cleaning validation limits. / 06.2017 / PubMed / Full text
Sex- and age-dependent gene expression in human liver: An implication for drug-metabolizing enzymes. / 02.2017 / PubMed / Full text

CYP2C8

Paclitaxel-induced sensory peripheral neuropathy is associated with an ABCB1 single nucleotide polymorphism and older age in Japanese. / 06.2017 / PubMed / Full text
Determination of Human Hepatic CYP2C8 and CYP1A2 Age-Dependent Expression to Support Human Health Risk Assessment for Early Ages. / 05.2017 / PubMed / Full text

CYP3A7

Dynamics of Cytosine Methylation in the Proximal Promoters of CYP3A4 and CYP3A7 in Pediatric and Prenatal Livers. / 07.2016 / PubMed / Full text
Predicting the "First dose in children" of CYP3A-metabolized drugs: Evaluation of scaling approaches and insights into the CYP3A7-CYP3A4 switch at young ages. / 09.2014 / PubMed / Full text

DAO

Age- and gender-dependent D-amino acid oxidase activity in mouse brain and peripheral tissues: implication for aging and neurodegeneration. / 01.08.2019 / PubMed / Full text
Blood levels of D-amino acid oxidase vs. D-amino acids in reflecting cognitive aging. / 01.11.2017 / PubMed / Full text

DAPK1

SerThr-PhosphoProteome of Brain from Aged PINK1-KO A53T-SNCA Mice Reveals pT1928-MAP1B and pS3781-ANK2 Deficits, as Hub between Autophagy and Synapse Changes. / 04.07.2019 / PubMed / Full text
Degradation of Caytaxin Causes Learning and Memory Deficits via Activation of DAPK1 in Aging. / 05.2019 / PubMed / Full text

DAXX

ATRX-DAXX Complex Expression Levels and Telomere Length in Normal Young and Elder Autopsy Human Brains. / 09.2019 / PubMed / Full text
Age-dependent differential expression of death-associated protein 6 (Daxx) in various peripheral tissues and different brain regions of C57BL/6 male mice. / 11.2016 / PubMed / Full text

DBT

Diurnal rhythms of heart and respiratory rates in donkeys of different age groups during the cold-dry and hot-dry seasons in a tropical savannah. / 09.2018 / PubMed / Full text
Anodal Transcranial Direct Current Stimulation Does Not Facilitate Dynamic Balance Task Learning in Healthy Old Adults. / 2017 / PubMed / Full text

DCD

Improved metabolism and redox state with a novel preservation solution: implications for donor lungs after cardiac death (DCD). / 04-06.2017 / PubMed / Full text
Functional connectivity of neural motor networks is disrupted in children with developmental coordination disorder and attention-deficit/hyperactivity disorder. / 2014 / PubMed / Full text

DCTN3

Dynactin pathway-related gene expression is altered by aging, but not by vitrification. / 09.2019 / PubMed / Full text
Alteration of Motor Protein Expression Involved in Bidirectional Transport in Peripheral Blood Mononuclear Cells of Patients with Amyotrophic Lateral Sclerosis. / 2016 / PubMed / Full text

DDAH1

Dimethylarginine Dimethylaminohydrolase 1 Deficiency Induces the Epithelial to Mesenchymal Transition in Renal Proximal Tubular Epithelial Cells and Exacerbates Kidney Damage in Aged and Diabetic Mice. / 01.12.2017 / PubMed / Full text
Epigallocatechin-3-gallate ameliorates erectile function in aged rats via regulation of PRMT1/DDAH/ADMA/NOS metabolism pathway. / 05-06.2017 / PubMed / Full text

DDAH2

Epigallocatechin-3-gallate ameliorates erectile function in aged rats via regulation of PRMT1/DDAH/ADMA/NOS metabolism pathway. / 05-06.2017 / PubMed / Full text
Regulation of endothelial progenitor cell differentiation and function by dimethylarginine dimethylaminohydrolase 2 in an asymmetric dimethylarginine-independent manner. / 09.2014 / PubMed / Full text

DDB1

DCAF1 regulates Treg senescence via the ROS axis during immunological aging. / 02.11.2020 / PubMed / Full text
Deletion of DDB1- and CUL4- associated factor-17 (Dcaf17) gene causes spermatogenesis defects and male infertility in mice. / 15.06.2018 / PubMed / Full text

DDR2

Selective Role of Discoidin Domain Receptor 2 in Murine Temporomandibular Joint Development and Aging. / 03.2018 / PubMed / Full text
Type I collagen aging impairs discoidin domain receptor 2-mediated tumor cell growth suppression. / 03.05.2016 / PubMed / Full text

DDX41

Salidroside influences the cellular cross-talk of human fetal lung diploid fibroblasts: A proteomic approach. / 03.2018 / PubMed / Full text
Sequential acquisition of mutations in myelodysplastic syndromes. / 2017 / PubMed / Full text

DEGS1

[Frailty: Prevalence in the Resident Population of Germany 70 - 79 Years of Age - a Population-Based Approach]. / 11.2017 / PubMed / Full text
Physical exercise and cognitive function across the life span: Results of a nationwide population-based study. / 05.2018 / PubMed / Full text

DGCR8

HPV shapes tumor transcriptome by globally modifying the pool of RNA binding protein-binding motif. / 29.04.2019 / PubMed / Full text
miRNAs 182 and 183 are necessary to maintain adult cone photoreceptor outer segments and visual function. / 06.08.2014 / PubMed / Full text

DHX9

The biology of DHX9 and its potential as a therapeutic target. / 05.07.2016 / PubMed / Full text
Suppression of the DHX9 helicase induces premature senescence in human diploid fibroblasts in a p53-dependent manner. / 15.08.2014 / PubMed / Full text

DIAPH1

Diaphanous 1 (DIAPH1) is Highly Expressed in the Aged Human Medial Temporal Cortex and Upregulated in Myeloid Cells During Alzheimer's Disease. / 2018 / PubMed / Full text
The multiple faces of RAGE--opportunities for therapeutic intervention in aging and chronic disease. / 2016 / PubMed / Full text

DIRAS3

Silencing of the small GTPase DIRAS3 induces cellular senescence in human white adipose stromal/progenitor cells. / 17.03.2017 / PubMed / Full text
Weight Loss Upregulates the Small GTPase DIRAS3 in Human White Adipose Progenitor Cells, Which Negatively Regulates Adipogenesis and Activates Autophagy via Akt-mTOR Inhibition. / 04.2016 / PubMed / Full text

DKK2

Low Serum Levels of DKK2 Predict Incident Low-Impact Fracture in Older Women. / 07.2019 / PubMed / Full text
Genome wide association and linkage analyses identified three loci-4q25, 17q23.2, and 10q11.21-associated with variation in leukocyte telomere length: the Long Life Family Study. / 2013 / PubMed / Full text

DLX5

Inhibition of microRNA-27b-3p relieves osteoarthritis pain via regulation of KDM4B-dependent DLX5. / 09.2020 / PubMed / Full text
Detection and evaluation of DNA methylation markers found at SCGN and KLF14 loci to estimate human age. / 11.2017 / PubMed / Full text

DNAJC5

Gene Therapy of Adult Neuronal Ceroid Lipofuscinoses with CRISPR/Cas9 in Zebrafish. / 07.2017 / PubMed / Full text
Caenorhabditis elegans dnj-14, the orthologue of the DNAJC5 gene mutated in adult onset neuronal ceroid lipofuscinosis, provides a new platform for neuroprotective drug screening and identifies a SIR-2.1-independent action of resveratrol. / 15.11.2014 / PubMed / Full text

DOCK11

[Immunosenescence: The Forefront of Infection and Trophic Control]. / 2020 / PubMed / Full text
Genetic correlation and genome-wide association study (GWAS) of the length of productive life, days open, and 305-days milk yield in crossbred Holstein dairy cattle. / 29.06.2017 / PubMed / Full text

DOT1L

Metformin regulates mitochondrial biogenesis and senescence through AMPK mediated H3K79 methylation: Relevance in age-associated vascular dysfunction. / 04.2018 / PubMed / Full text
NF-κB activation impairs somatic cell reprogramming in ageing. / 08.2015 / PubMed / Full text

DRAM1

Genome-wide meta-analysis of macronutrient intake of 91,114 European ancestry participants from the cohorts for heart and aging research in genomic epidemiology consortium. / 12.2019 / PubMed / Full text
Di-retinoid-pyridinium-ethanolamine (A2E) Accumulation and the Maintenance of the Visual Cycle Are Independent of Atg7-mediated Autophagy in the Retinal Pigmented Epithelium. / 27.11.2015 / PubMed / Full text

DRD4

ADHD risk genes involved in dopamine signaling and metabolism are associated with reduced estimated life expectancy at young adult follow-up in hyperactive and control children. / 04.2019 / PubMed / Full text
Age-dependent role of pre- and perinatal factors in interaction with genes on ADHD symptoms across adolescence. / 07.2017 / PubMed / Full text

DROSHA

Profiling of m6A RNA modifications identified an age-associated regulation of AGO2 mRNA stability. / 06.2018 / PubMed / Full text
Centenarians maintain miRNA biogenesis pathway while it is impaired in octogenarians. / 12.2017 / PubMed / Full text

DSCAM

Age- and speed-dependent modulation of gaits in DSCAM mutant mice. / 01.02.2018 / PubMed / Full text
Developmentally dynamic colocalization patterns of DSCAM with adhesion and synaptic proteins in the mouse retina. / 2014 / PubMed / Full text

DSE

Impact of Intensive Lifestyle Intervention on Disability-Free Life Expectancy: The Look AHEAD Study. / 05.2018 / PubMed / Full text
Changes in regional body composition over 8 years in a randomized lifestyle trial: The look AHEAD study. / 09.2016 / PubMed / Full text

DUSP16

Nicotinamide Mononucleotide, an NAD Precursor, Rescues Age-Associated Susceptibility to AKI in a Sirtuin 1-Dependent Manner. / 08.2017 / PubMed / Full text
DUSP16 ablation arrests the cell cycle and induces cellular senescence. / 12.2015 / PubMed / Full text

E2F2

MicroRNA-31a-5p from aging BMSCs links bone formation and resorption in the aged bone marrow microenvironment. / 08.2018 / PubMed / Full text
In situ regeneration of retinal pigment epithelium by gene transfer of E2F2: a potential strategy for treatment of macular degenerations. / 12.2017 / PubMed / Full text

EBF1

Genome-wide Association Study of Parental Life Span. / 01.10.2017 / PubMed / Full text
Non-Lethal Ionizing Radiation Promotes Aging-Like Phenotypic Changes of Human Hematopoietic Stem and Progenitor Cells in Humanized Mice. / 2015 / PubMed / Full text

ECM1

Novel role of extracellular matrix protein 1 (ECM1) in cardiac aging and myocardial infarction. / 2019 / PubMed / Full text
Extended Multiplexing of Tandem Mass Tags (TMT) Labeling Reveals Age and High Fat Diet Specific Proteome Changes in Mouse Epididymal Adipose Tissue. / 05.2017 / PubMed / Full text

EDARADD

Age prediction in living: Forensic epigenetic age estimation based on blood samples. / 11.2020 / PubMed / Full text
DNA methylation levels in candidate genes associated with chronological age in mammals are not conserved in a long-lived seabird. / 2017 / PubMed / Full text

EIF2B1

Mendelian adult-onset leukodystrophy genes in Alzheimer's disease: critical influence of CSF1R and NOTCH3. / 06.2018 / PubMed / Full text
Infantile onset Vanishing White Matter disease associated with a novel EIF2B5 variant, remarkably long life span, severe epilepsy, and hypopituitarism. / 04.2015 / PubMed / Full text

EIF2B5

Mendelian adult-onset leukodystrophy genes in Alzheimer's disease: critical influence of CSF1R and NOTCH3. / 06.2018 / PubMed / Full text
Infantile onset Vanishing White Matter disease associated with a novel EIF2B5 variant, remarkably long life span, severe epilepsy, and hypopituitarism. / 04.2015 / PubMed / Full text

EMB

XRCC1 and XPD genetic polymorphisms and susceptibility to age-related cataract: a meta-analysis. / 2015 / PubMed / Full text
Diabetes self-management programmes in older adults: a systematic review and meta-analysis. / 11.2015 / PubMed / Full text

EMD

Transcriptome analysis of human cumulus cells reveals hypoxia as the main determinant of follicular senescence. / 08.2016 / PubMed / Full text
Electromechanical delay of the knee extensor muscles: comparison among young, middle-age and older individuals. / 07.2015 / PubMed / Full text

EN1

Electrochemically detecting DNA methylation in the EN1 gene promoter: implications for understanding ageing and disease. / 27.11.2020 / PubMed / Full text
The role of DNA methylation in ageing and cancer. / 11.2018 / PubMed / Full text

ENC1

Selective molecular biomarkers to predict biologic behavior in pituitary tumors. / 05.2017 / PubMed / Full text
Identification of genes associated with dissociation of cognitive performance and neuropathological burden: Multistep analysis of genetic, epigenetic, and transcriptional data. / 04.2017 / PubMed / Full text

ENO1

Reduced expression of enolase-1 correlates with high intracellular glucose levels and increased senescence in cisplatin-resistant ovarian cancer cells. / 2020 / PubMed / Full text
Targeting the Warburg effect in cancer cells through ENO1 knockdown rescues oxidative phosphorylation and induces growth arrest. / 02.02.2016 / PubMed / Full text

ENTPD7

Inhibition of lung cancer cells and Ras/Raf/MEK/ERK signal transduction by ectonucleoside triphosphate phosphohydrolase-7 (ENTPD7). / 23.08.2019 / PubMed / Full text
SWI/SNF regulates a transcriptional program that induces senescence to prevent liver cancer. / 01.10.2016 / PubMed / Full text

EPHA2

Germ-line and somatic EPHA2 coding variants in lens aging and cataract. / 2017 / PubMed / Full text
EPHA2 Polymorphisms in Estonian Patients with Age-Related Cataract. / 2016 / PubMed / Full text

EPM2A

Inflammation in Lafora Disease: Evolution with Disease Progression in Laforin and Malin Knock-out Mouse Models. / 07.2017 / PubMed / Full text
Loss of GABAergic cortical neurons underlies the neuropathology of Lafora disease. / 28.01.2014 / PubMed / Full text

ERBB2

The biological age linked to oxidative stress modifies breast cancer aggressiveness. / 20.05.2018 / PubMed / Full text
Identification of human age-associated gene co-expressions in functional modules using liquid association. / 02.01.2018 / PubMed / Full text

ERCC2

The genetic component of human longevity: New insights from the analysis of pathway-based SNP-SNP interactions. / 06.2018 / PubMed / Full text
XRCC1 and XPD genetic polymorphisms and susceptibility to age-related cataract: a meta-analysis. / 2015 / PubMed / Full text

EWSR1

EWSR1, a multifunctional protein, regulates cellular function and aging via genetic and epigenetic pathways. / 01.07.2019 / PubMed / Full text
EWSR1/ELF5 induces acute myeloid leukemia by inhibiting p53/p21 pathway. / 12.2016 / PubMed / Full text

EXO1

Polymorphisms of the DNA repair gene EXO1 modulate cognitive aging in old adults in a Taiwanese population. / 06.2019 / PubMed / Full text
Exonuclease 1 and its versatile roles in DNA repair. / 11-12.2016 / PubMed / Full text

FAHD1

Oxaloacetate decarboxylase FAHD1 - a new regulator of mitochondrial function and senescence. / 01.2019 / PubMed / Full text
Depletion of oxaloacetate decarboxylase FAHD1 inhibits mitochondrial electron transport and induces cellular senescence in human endothelial cells. / 06.2017 / PubMed / Full text

FANCD2

TFG-maintaining stability of overlooked FANCD2 confers early DNA-damage response. / 24.10.2020 / PubMed / Full text
FANCD2 and DNA Damage. / 19.08.2017 / PubMed / Full text

FASN

Expression of lipogenic markers is decreased in subcutaneous adipose tissue and adipocytes of older women and is negatively linked to GDF15 expression. / 08.2019 / PubMed / Full text
Fatty acid synthase is a metabolic marker of cell proliferation rather than malignancy in ovarian cancer and its precursor cells. / 01.05.2015 / PubMed / Full text

FBN1

Extended Multiplexing of Tandem Mass Tags (TMT) Labeling Reveals Age and High Fat Diet Specific Proteome Changes in Mouse Epididymal Adipose Tissue. / 05.2017 / PubMed / Full text
Muscle and Bone Impairment in Children With Marfan Syndrome: Correlation With Age and FBN1 Genotype. / 08.2015 / PubMed / Full text

FBN2

Assessment of Human Skin Gene Expression by Different Blends of Plant Extracts with Implications to Periorbital Skin Aging. / 26.10.2018 / PubMed / Full text
Extended Multiplexing of Tandem Mass Tags (TMT) Labeling Reveals Age and High Fat Diet Specific Proteome Changes in Mouse Epididymal Adipose Tissue. / 05.2017 / PubMed / Full text

FBXO31

The SCF ubiquitin ligase complex mediates degradation of the tumor suppressor FBXO31 and thereby prevents premature cellular senescence. / 19.10.2018 / PubMed / Full text
Solutions to Peto's paradox revealed by mathematical modelling and cross-species cancer gene analysis. / 19.07.2015 / PubMed / Full text

FEN1

The Werner Syndrome Helicase Coordinates Sequential Strand Displacement and FEN1-Mediated Flap Cleavage during Polymerase δ Elongation. / 01.02.2017 / PubMed / Full text
RECQL5 has unique strand annealing properties relative to the other human RecQ helicase proteins. / 01.2016 / PubMed / Full text

FGF6

Genome-wide associations and detection of potential candidate genes for direct genetic and maternal genetic effects influencing dairy cattle body weight at different ages. / 06.02.2019 / PubMed / Full text
Regulation of skeletal muscle stem cells by fibroblast growth factors. / 05.2017 / PubMed / Full text

FGFR2

Oncogenic mutations in histologically normal endometrium: the new normal? / 10.2019 / PubMed / Full text
Inducible Activation of FGFR2 in Adult Mice Promotes Bone Formation After Bone Marrow Ablation. / 11.2017 / PubMed / Full text

FGFR4

FGFR4 Inhibitor BLU9931 Attenuates Pancreatic Cancer Cell Proliferation and Invasion While Inducing Senescence: Evidence for Senolytic Therapy Potential in Pancreatic Cancer. / 14.10.2020 / PubMed / Full text
The Klotho proteins in health and disease. / 01.2019 / PubMed / Full text

FHL1

The forkhead-like transcription factor (Fhl1p) maintains yeast replicative lifespan by regulating ribonucleotide reductase 1 (RNR1) gene transcription. / 17.06.2017 / PubMed / Full text
Transcription factor genes essential for cell proliferation and replicative lifespan in budding yeast. / 31.07.2015 / PubMed / Full text

FLT1

Novel molecular mechanisms for the adaptogenic effects of herbal extracts on isolated brain cells using systems biology. / 15.11.2018 / PubMed / Full text
Analysis of Polymorphisms in 59 Potential Candidate Genes for Association With Human Longevity. / 08.10.2018 / PubMed / Full text

FN1

Systems biology and network pharmacology of frailty reveal novel epigenetic targets and mechanisms. / 22.07.2019 / PubMed / Full text
Effects of Fibronectin 1 on Cell Proliferation, Senescence and Apoptosis of Human Glioma Cells Through the PI3K/AKT Signaling Pathway. / 2018 / PubMed / Full text

FOXA2

Induced Pluripotent Stem Cell-Derived Dopaminergic Neurons from Adult Common Marmoset Fibroblasts. / 01.09.2017 / PubMed / Full text
Epigenetic mechanisms of peptidergic regulation of gene expression during aging of human cells. / 03.2015 / PubMed / Full text

FOXC1

Identification of key genes and transcription factors in aging mesenchymal stem cells by DNA microarray data. / 15.04.2019 / PubMed / Full text
FOXC1 maintains the hair follicle stem cell niche and governs stem cell quiescence to preserve long-term tissue-regenerating potential. / 15.03.2016 / PubMed / Full text

FOXF1

Functional CRISPR screen identifies AP1-associated enhancer regulating FOXF1 to modulate oncogene-induced senescence. / 17.08.2018 / PubMed / Full text
Co-culturing nucleus pulposus mesenchymal stem cells with notochordal cell-rich nucleus pulposus explants attenuates tumor necrosis factor-α-induced senescence. / 26.06.2018 / PubMed / Full text

FOXL2

Human amniotic mesenchymal stem cells improve ovarian function in natural aging through secreting hepatocyte growth factor and epidermal growth factor. / 09.03.2018 / PubMed / Full text
Different therapeutic effects of cells derived from human amniotic membrane on premature ovarian aging depend on distinct cellular biological characteristics. / 27.07.2017 / PubMed / Full text

FSHB

Causal mechanisms and balancing selection inferred from genetic associations with polycystic ovary syndrome. / 29.09.2015 / PubMed / Full text
'Carriers of variant luteinizing hormone (V-LH) among 1593 Baltic men have significantly higher serum LH'. / 05.2015 / PubMed / Full text

FSTL3

Activin type II receptor signaling in cardiac aging and heart failure. / 06.03.2019 / PubMed / Full text
Physiology of Activins/Follistatins: Associations With Metabolic and Anthropometric Variables and Response to Exercise. / 01.10.2018 / PubMed / Full text

FXN

Two different pathogenic mechanisms, dying-back axonal neuropathy and pancreatic senescence, are present in the YG8R mouse model of Friedreich's ataxia. / 01.06.2016 / PubMed / Full text
Mitochondrial dysfunction induced by frataxin deficiency is associated with cellular senescence and abnormal calcium metabolism. / 2014 / PubMed / Full text

GAS6

Regulatory T-cells regulate neonatal heart regeneration by potentiating cardiomyocyte proliferation in a paracrine manner. / 2019 / PubMed / Full text
Red blood cell distribution width: Genetic evidence for aging pathways in 116,666 volunteers. / 2017 / PubMed / Full text

GATA2

GATA2 hypomorphism induces chronic myelomonocytic leukemia in mice. / 04.2019 / PubMed / Full text
Sequential acquisition of mutations in myelodysplastic syndromes. / 2017 / PubMed / Full text

GCAT

Impairing L-Threonine Catabolism Promotes Healthspan through Methylglyoxal-Mediated Proteohormesis. / 03.04.2018 / PubMed / Full text
Epigenetic regulation of the nuclear-coded GCAT and SHMT2 genes confers human age-associated mitochondrial respiration defects. / 22.05.2015 / PubMed / Full text

GCKR

The ADAMTS9 gene is associated with cognitive aging in the elderly in a Taiwanese population. / 2017 / PubMed / Full text
Genomewide meta-analysis identifies loci associated with IGF-I and IGFBP-3 levels with impact on age-related traits. / 10.2016 / PubMed / Full text

GDF3

In vivo GDF3 administration abrogates aging related muscle regeneration delay following acute sterile injury. / 10.2018 / PubMed / Full text
Inflammasome-driven catecholamine catabolism in macrophages blunts lipolysis during ageing. / 05.10.2017 / PubMed / Full text

GDF9

Observation of the influences of diosgenin on aging ovarian reserve and function in a mouse model. / 18.10.2017 / PubMed / Full text
Effects of aging on gene expression and mitochondrial DNA in the equine oocyte and follicle cells. / 07.2015 / PubMed / Full text

GIT1

GIT2-A keystone in ageing and age-related disease. / 05.2018 / PubMed / Full text
GluN3A promotes dendritic spine pruning and destabilization during postnatal development. / 09.07.2014 / PubMed / Full text

GLB1

Docosahexaenoic acid prevented tumor necrosis factor alpha-induced endothelial dysfunction and senescence. / 01.2016 / PubMed / Full text
Defective autophagy in vascular smooth muscle cells accelerates senescence and promotes neointima formation and atherogenesis. / 02.11.2015 / PubMed / Full text

GLI1

Sonic hedgehog regulation of cavernous nerve regeneration and neurite formation in aged pelvic plexus. / 02.2019 / PubMed / Full text
GLI1 progenitor cells in the adrenal capsule of the adult mouse give rise to heterotopic gonadal-like tissue. / 05.02.2017 / PubMed / Full text

GLRX

Gender- and region-dependent changes of redox biomarkers in the brain of successfully aging LOU/C rats. / 07.2015 / PubMed / Full text
Contribution of genetic polymorphisms on functional status at very old age: a gene-based analysis of 38 genes (311 SNPs) in the oxidative stress pathway. / 04.2014 / PubMed / Full text

GNB3

Ablation of EYS in zebrafish causes mislocalisation of outer segment proteins, F-actin disruption and cone-rod dystrophy. / 05.04.2017 / PubMed / Full text
GNB3, eNOS, and mitochondrial DNA polymorphisms correlate to natural longevity in a Xinjiang Uygur population. / 2013 / PubMed / Full text

GNG3

Gene Expression Analysis Reveals Novel Gene Signatures Between Young and Old Adults in Human Prefrontal Cortex. / 2018 / PubMed / Full text
Low expression of aging-related [[NRXN3]] is associated with Alzheimer disease: A systematic review and meta-analysis. / 07.2018 / PubMed / Full text

GNRH1

Novel molecular mechanisms for the adaptogenic effects of herbal extracts on isolated brain cells using systems biology. / 15.11.2018 / PubMed / Full text
Elucidating the genetic architecture of reproductive ageing in the Japanese population. / 17.05.2018 / PubMed / Full text

GP6

Novel molecular mechanisms for the adaptogenic effects of herbal extracts on isolated brain cells using systems biology. / 15.11.2018 / PubMed / Full text
Estimation of human age using N-glycan profiles from bloodstains. / 09.2015 / PubMed / Full text

GPER1

30 YEARS OF THE MINERALOCORTICOID RECEPTOR: Nongenomic effects via the mineralocorticoid receptor. / 07.2017 / PubMed / Full text
Diverse Synaptic Distributions of G Protein-coupled Estrogen Receptor 1 in Monkey Prefrontal Cortex with Aging and Menopause. / 01.03.2017 / PubMed / Full text

GPR17

Pharmaceutical Rejuvenation of Age-Associated Decline in Spatial Memory. / 12.2016 / PubMed / Full text
Structural and functional rejuvenation of the aged brain by an approved anti-asthmatic drug. / 27.10.2015 / PubMed / Full text

GPR3

Mice lacking GPR3 receptors display late-onset obese phenotype due to impaired thermogenic function in brown adipose tissue. / 12.10.2015 / PubMed / Full text
Effects of aging on gene expression and mitochondrial DNA in the equine oocyte and follicle cells. / 07.2015 / PubMed / Full text

GPR39

Zinc-mediated Neurotransmission in Alzheimer's Disease: A Potential Role of the GPR39 in Dementia. / 2020 / PubMed / Full text
GPR39 agonist TC-G 1008 ameliorates IL-1β-induced chondrocyte senescence. / 12.2019 / PubMed / Full text

GPR55

Age-dependent plasticity in endocannabinoid modulation of pain processing through postnatal development. / 11.2017 / PubMed / Full text
GPR55 deletion in mice leads to age-related ventricular dysfunction and impaired adrenoceptor-mediated inotropic responses. / 2014 / PubMed / Full text

GRB10

De-silencing [i]Grb10[/i] contributes to acute ER stress-induced steatosis in mouse liver. / 05.2018 / PubMed / Full text
Exercise-associated DNA methylation change in skeletal muscle and the importance of imprinted genes: a bioinformatics meta-analysis. / 12.2015 / PubMed / Full text

GRB2

Fucoidan⁻Fucoxanthin Ameliorated Cardiac Function via IRS1/GRB2/ SOS1, GSK3β/CREB Pathways and Metabolic Pathways in Senescent Mice. / 21.01.2019 / PubMed / Full text
The different expression profiles of microRNAs in elderly and young human dental pulp and the role of miR-433 in human dental pulp cells. / 03.2015 / PubMed / Full text

GRIA2

The EpiTect Methyl qPCR Assay as novel age estimation method in forensic biology. / 07.2016 / PubMed / Full text
Evaluation of DNA methylation markers and their potential to predict human aging. / 08.2015 / PubMed / Full text

GRIK2

Senescence of Normal Human Fibroblasts Relates to the Expression of Ionotropic Glutamate Receptor GluR6/Grik2. / 11-12.2020 / PubMed / Full text
Isoforms of Ionotropic Glutamate Receptor GRIK2 Induce Senescence of Carcinoma Cells. / 01-02.2019 / PubMed / Full text

GRIN2B

Medial temporal lobe atrophy relates more strongly to sleep-wake rhythm fragmentation than to age or any other known risk. / 04.2019 / PubMed / Full text
Gene Expression Switching of Receptor Subunits in Human Brain Development. / 12.2015 / PubMed / Full text

GRM3

Profiling gene expression in the human dentate gyrus granule cell layer reveals insights into schizophrenia and its genetic risk. / 04.2020 / PubMed / Full text
Hippocampal proteomics defines pathways associated with memory decline and resilience in normal aging and Alzheimer's disease mouse models. / 30.03.2017 / PubMed / Full text

GRSF1

GRSF1 is an age-related regulator of senescence. / 03.04.2019 / PubMed / Full text
GRSF1 suppresses cell senescence. / 07.08.2018 / PubMed / Full text

GSTA1

Age-associated changes in GSH S-transferase gene/proteins in livers of rats. / 12.2018 / PubMed / Full text
Effects of insulin-like growth factor 1 on glutathione S-transferases and thioredoxin in growth hormone receptor knockout mice. / 2014 / PubMed / Full text

GSTA4

Impaired enzymatic reactive aldehyde-detoxifying capacity and glutathione peroxidase activity in the aged human arterial tissue. / 02.2019 / PubMed / Full text
Age-associated changes in GSH S-transferase gene/proteins in livers of rats. / 12.2018 / PubMed / Full text

GSTM3

Age-associated changes in GSH S-transferase gene/proteins in livers of rats. / 12.2018 / PubMed / Full text
Relationship Between the Altered Expression and Epigenetics of GSTM3 and Age-Related Cataract. / 01.09.2016 / PubMed / Full text

GSTZ1

Age-associated changes in GSH S-transferase gene/proteins in livers of rats. / 12.2018 / PubMed / Full text
Effects of insulin-like growth factor 1 on glutathione S-transferases and thioredoxin in growth hormone receptor knockout mice. / 2014 / PubMed / Full text

HAMP

A potent tilapia secreted granulin peptide enhances the survival of transgenic zebrafish infected by Vibrio vulnificus via modulation of innate immunity. / 04.2018 / PubMed / Full text
Longitudinal Relationships between Reproductive Hormones and Cognitive Decline in Older Men: The Concord Health and Ageing in Men Project. / 06.2015 / PubMed / Full text

HAPLN1

Remodeling of the Collagen Matrix in Aging Skin Promotes Melanoma Metastasis and Affects Immune Cell Motility. / 01.2019 / PubMed / Full text
Age-Related Changes in HAPLN1 Increase Lymphatic Permeability and Affect Routes of Melanoma Metastasis. / 01.2019 / PubMed / Full text

HAS1

A large-scale CRISPR screen and identification of essential genes in cellular senescence bypass. / 20.06.2019 / PubMed / Full text
Age-related changes in cyclic phosphatidic acid-induced hyaluronic acid synthesis in human fibroblasts. / 01.2018 / PubMed / Full text

HBD

Impact of reproductive aging on the vaginal microbiome and soluble immune mediators in women living with and at-risk for HIV infection. / 2019 / PubMed / Full text
Differences in Cytokine Production during Aging and Its Relationship with Antimicrobial Peptides Production. / 01.2017 / PubMed / Full text

HCN3

Characteristics of hyperpolarization-activated cyclic nucleotide-gated channels in dorsal root ganglion neurons at different ages and sizes. / 11.11.2015 / PubMed / Full text
Integromics network meta-analysis on cardiac aging offers robust multi-layer modular signatures and reveals micronome synergism. / 04.03.2015 / PubMed / Full text

HGD

High-glucose diets induce mitochondrial dysfunction in Caenorhabditis elegans. / 2019 / PubMed / Full text
A high glucose diet induces autophagy in a HLH-30/TFEB-dependent manner and impairs the normal lifespan of [i]C. elegans[/i]. / 05.10.2018 / PubMed / Full text

HIF1A

Hypoxia-inducible transcription factors, HIF1A and HIF2A, increase in aging mucosal tissues. / 07.2018 / PubMed / Full text
Role of Mitochondrial Complex IV in Age-Dependent Obesity. / 13.09.2016 / PubMed / Full text

HK2

Resveratrol, an Nrf2 activator, ameliorates aging-related progressive renal injury. / 11.01.2018 / PubMed / Full text
Differentially expressed microRNAs in bone marrow mesenchymal stem cell-derived microvesicles in young and older rats and their effect on tumor growth factor-β1-mediated epithelial-mesenchymal transition in HK2 cells. / 28.09.2015 / PubMed / Full text

HLA-B

Epigenome-wide exploratory study of monozygotic twins suggests differentially methylated regions to associate with hand grip strength. / 10.2019 / PubMed / Full text
Cytomegalovirus-Specific T Cells Restricted by HLA-Cw*0702 Increase Markedly with Age and Dominate the CD8 T-Cell Repertoire in Older People. / 2017 / PubMed / Full text

HLA-C

Epigenome-wide exploratory study of monozygotic twins suggests differentially methylated regions to associate with hand grip strength. / 10.2019 / PubMed / Full text
Cytomegalovirus-Specific T Cells Restricted by HLA-Cw*0702 Increase Markedly with Age and Dominate the CD8 T-Cell Repertoire in Older People. / 2017 / PubMed / Full text

HLA-DPB1

17th IHIW component "Immunogenetics of Ageing" - New NGS data. / 09.2019 / PubMed / Full text
Epigenome-wide exploratory study of monozygotic twins suggests differentially methylated regions to associate with hand grip strength. / 10.2019 / PubMed / Full text

HLA-DQA1

17th IHIW component "Immunogenetics of Ageing" - New NGS data. / 09.2019 / PubMed / Full text
[Clinical and genetic characteristics of long-livers in Moscow region]. / 2013 / PubMed

HLA-DQB1

Identification of new genetic variants of HLA-DQB1 associated with human longevity and lipid homeostasis-a cross-sectional study in a Chinese population. / 10.11.2017 / PubMed / Full text
[Clinical and genetic characteristics of long-livers in Moscow region]. / 2013 / PubMed

HMGCS1

The Age-dependent Elevation of miR-335-3p Leads to Reduced Cholesterol and Impaired Memory in Brain. / 15.10.2018 / PubMed / Full text
Controlled sumoylation of the mevalonate pathway enzyme HMGS-1 regulates metabolism during aging. / 16.09.2014 / PubMed / Full text

HNRNPA1

HNRNPA1-mediated 3' UTR length changes of [i]HN1[/i] contributes to cancer- and senescence-associated phenotypes. / 30.06.2019 / PubMed / Full text
Changes in the expression of splicing factor transcripts and variations in alternative splicing are associated with lifespan in mice and humans. / 10.2016 / PubMed / Full text

HOPX

Combinations of differentiation markers distinguish subpopulations of alveolar epithelial cells in adult lung. / 15.01.2016 / PubMed / Full text
HOPX is methylated and exerts tumour-suppressive function through Ras-induced senescence in human lung cancer. / 02.2015 / PubMed / Full text

HOXC4

Chronological age prediction based on DNA methylation: Massive parallel sequencing and random forest regression. / 11.2017 / PubMed / Full text
Differential DNA Methylation in Relation to Age and Health Risks of Obesity. / 24.07.2015 / PubMed / Full text

HPD

Protein-Amino Acid Metabolism Disarrangements: The Hidden Enemy of Chronic Age-Related Conditions. / 22.03.2018 / PubMed / Full text
Post-weaning parental care increases fitness but is not heritable in North American red squirrels. / 06.2015 / PubMed / Full text

HRG

Chronic dietary ginseng extract administration ameliorates antioxidant and cholinergic systems in the brains of aged mice. / 10.2017 / PubMed / Full text
Heregulin, a new regulator of telomere length in human cells. / 24.11.2015 / PubMed / Full text

HSD3B2

11-Oxygenated C19 Steroids Do Not Decline With Age in Women. / 01.07.2019 / PubMed / Full text
Testicular gene expression of steroidogenesis-related factors in prepubertal, postpubertal, and aging dogs. / 01.03.2017 / PubMed / Full text

HSP90AA1

SIRT6 histone deacetylase functions as a potential oncogene in human melanoma. / 09.2017 / PubMed / Full text
Integration-independent Transgenic Huntington Disease Fragment Mouse Models Reveal Distinct Phenotypes and Life Span in Vivo. / 31.07.2015 / PubMed / Full text

HSPB1

The beneficial effects of 15 units of high-intensity circuit training in women is modified by age, baseline insulin resistance and physical capacity. / 06.2019 / PubMed / Full text
Chicken heat shock protein HSPB1 increases and interacts with αB-crystallin in aged skeletal muscle. / 2015 / PubMed / Full text

HSPB6

Lifelong Football Training: Effects on Autophagy and Healthy Longevity Promotion. / 2019 / PubMed / Full text
Apoptosis in muscle-to-meat aging process: The omic witness. / 01.07.2015 / PubMed / Full text

HTRA1

Mendelian adult-onset leukodystrophy genes in Alzheimer's disease: critical influence of CSF1R and NOTCH3. / 06.2018 / PubMed / Full text
Fibrotic-like changes in degenerate human intervertebral discs revealed by quantitative proteomic analysis. / 03.2016 / PubMed / Full text

HUS1

Lifespan and Stress Resistance in Drosophila with Overexpressed DNA Repair Genes. / 19.10.2015 / PubMed / Full text
[Role of DNA repair genes in radiation-induced changes of lifespan of Drosophila melanogaster]. / 09-10.2014 / PubMed

IAPP

Protein aggregates and proteostasis in aging: Amylin and β-cell function. / 01.2019 / PubMed / Full text
Causative factors for formation of toxic islet amyloid polypeptide oligomer in type 2 diabetes mellitus. / 2015 / PubMed / Full text

ICAM1

An Inhibitor of Activated Blood Coagulation Factor X Shows Anti-Endothelial Senescence and Anti-Atherosclerotic Effects. / 2019 / PubMed / Full text
Effect of age on expression of spermatogonial markers in bovine testis and isolated cells. / 07.2016 / PubMed / Full text

ID3

Transcription factor networks in aged naïve CD4 T cells bias lineage differentiation. / 08.2019 / PubMed / Full text
Proteomics and metabolomics identify molecular mechanisms of aging potentially predisposing for chronic lymphocytic leukemia. / 02.2018 / PubMed / Full text

IFIT1

Sirtuin 1-Chromatin-Binding Dynamics Points to a Common Mechanism Regulating Inflammatory Targets in SIV Infection and in the Aging Brain. / 06.2018 / PubMed / Full text
Progression of pathology in PINK1-deficient mouse brain from splicing via ubiquitination, ER stress, and mitophagy changes to neuroinflammation. / 02.08.2017 / PubMed / Full text

IFIT3

Progression of pathology in PINK1-deficient mouse brain from splicing via ubiquitination, ER stress, and mitophagy changes to neuroinflammation. / 02.08.2017 / PubMed / Full text
Extended Multiplexing of Tandem Mass Tags (TMT) Labeling Reveals Age and High Fat Diet Specific Proteome Changes in Mouse Epididymal Adipose Tissue. / 05.2017 / PubMed / Full text

IFNAR1

Suppression of Type I Interferon Signaling Overcomes Oncogene-Induced Senescence and Mediates Melanoma Development and Progression. / 05.04.2016 / PubMed / Full text
Type 1 interferons contribute to the clearance of senescent cell. / 2015 / PubMed / Full text

IGFBP1

Role of IGFBP1 in the senescence of vascular endothelial cells and severity of aging‑related coronary atherosclerosis. / 11.2019 / PubMed / Full text
Dehydroepiandrosterone enhances decidualization in women of advanced reproductive age. / 04.2018 / PubMed / Full text

IGFBP4

Quantitative iTRAQ-based proteomic analysis of differentially expressed proteins in aging in human and monkey. / 11.10.2019 / PubMed / Full text
Age-Related Insulin-Like Growth Factor Binding Protein-4 Overexpression Inhibits Osteogenic Differentiation of Rat Mesenchymal Stem Cells. / 2017 / PubMed / Full text

IHH

Indian Hedgehog regulates senescence in bone marrow-derived mesenchymal stem cell through modulation of ROS/mTOR/4EBP1, p70S6K1/2 pathway. / 01.04.2020 / PubMed / Full text
Transfection of the IHH gene into rabbit BMSCs in a simulated microgravity environment promotes chondrogenic differentiation and inhibits cartilage aging. / 27.09.2016 / PubMed / Full text

IL13

Age-specific changes in the molecular phenotype of patients with moderate-to-severe atopic dermatitis. / 07.2019 / PubMed / Full text
IL10-driven STAT3 signalling in senescent macrophages promotes pathological eye angiogenesis. / 11.08.2015 / PubMed / Full text

IL1R2

Lower levels of interleukin-1β gene expression are associated with impaired Langerhans' cell migration in aged human skin. / 01.2018 / PubMed / Full text
A genome-wide scan reveals important roles of DNA methylation in human longevity by regulating age-related disease genes. / 2015 / PubMed / Full text

IL6R

Chronic Resveratrol Treatment Inhibits MRC5 Fibroblast SASP-Related Protumoral Effects on Melanoma Cells. / 01.09.2017 / PubMed / Full text
No Association between Variation in Longevity Candidate Genes and Aging-related Phenotypes in Oldest-old Danes. / 06.2016 / PubMed / Full text

IL7

SCAMP4 enhances the senescent cell secretome. / 01.07.2018 / PubMed / Full text
Thymic Atrophy: Experimental Studies and Therapeutic Interventions. / 01.2018 / PubMed / Full text

ILDR1

Genome-wide association meta-analysis identifies five novel loci for age-related hearing impairment. / 23.10.2019 / PubMed / Full text
A Large Genome-Wide Association Study of Age-Related Hearing Impairment Using Electronic Health Records. / 10.2016 / PubMed / Full text

ING1

Impaired DNA demethylation of C/EBP sites causes premature aging. / 01.06.2018 / PubMed / Full text
The tumor suppressor ING1b is a novel corepressor for the androgen receptor and induces cellular senescence in prostate cancer cells. / 06.2016 / PubMed / Full text

INPP5A

DNA methylation analysis on purified neurons and glia dissects age and Alzheimer's disease-specific changes in the human cortex. / 25.07.2018 / PubMed / Full text
Coordinated Expression of Phosphoinositide Metabolic Genes during Development and Aging of Human Dorsolateral Prefrontal Cortex. / 2015 / PubMed / Full text

IQGAP1

IQGAP1-dysfunction leads to induction of senescence in human vascular smooth muscle cells. / 09.2020 / PubMed / Full text
Hyaluronan-binding protein 1 (HABP1) overexpression triggers induction of senescence in fibroblasts cells. / 06.2020 / PubMed / Full text

IRF4

Transcription factor networks in aged naïve CD4 T cells bias lineage differentiation. / 08.2019 / PubMed / Full text
Age-related differences in interferon regulatory factor-4 and -5 signaling in ischemic brains of mice. / 11.2017 / PubMed / Full text

IRGM

SIRT6 histone deacetylase functions as a potential oncogene in human melanoma. / 09.2017 / PubMed / Full text
Bt Cry1Ie Toxin Does Not Impact the Survival and Pollen Consumption of Chinese Honey Bees, Apis cerana cerana (Hymenoptera, Apidae). / 01.12.2016 / PubMed / Full text

ITGAM

Comparative Analysis of Gene Expression Patterns for Oral Epithelium-Related Functions with Aging. / 2019 / PubMed / Full text
Transcriptomic analysis of purified human cortical microglia reveals age-associated changes. / 08.2017 / PubMed / Full text

ITGB3

Integrin Beta 3 Regulates Cellular Senescence by Activating the TGF-β Pathway. / 07.03.2017 / PubMed / Full text
[Clinical and genetic characteristics of long-livers in Moscow region]. / 2013 / PubMed

ITK

Does Tetralogy of Fallot affect brain aging? A proof-of-concept study. / 2018 / PubMed / Full text
Phenotypic characteristics of aged CD4 CD28 T lymphocytes are determined by changes in the whole-genome DNA methylation pattern. / 04.2017 / PubMed / Full text

JAK3

Immunologic effects of chronic administration of tofacitinib, a Janus kinase inhibitor, in cynomolgus monkeys and rats - Comparison of juvenile and adult responses. / 04.2018 / PubMed / Full text
IL-15 enhances the antitumor effect of human antigen-specific CD8 T cells by cellular senescence delay. / 2016 / PubMed / Full text

KDM2B

Identification of Structural Elements of the Lysine Specific Demethylase 2B CxxC Domain Associated with Replicative Senescence Bypass in Primary Mouse Cells. / 06.2020 / PubMed / Full text
Hypoxia-Inducible Histone Lysine Demethylases: Impact on the Aging Process and Age-Related Diseases. / 03.2016 / PubMed / Full text

KDM3A

KDM3A and KDM4C Regulate Mesenchymal Stromal Cell Senescence and Bone Aging via Condensin-mediated Heterochromatin Reorganization. / 22.11.2019 / PubMed / Full text
Hypoxia-Inducible Histone Lysine Demethylases: Impact on the Aging Process and Age-Related Diseases. / 03.2016 / PubMed / Full text

KDM6B

Histone demethylase KDM6B regulates 1,25-dihydroxyvitamin D3-induced senescence in glioma cells. / 08.2019 / PubMed / Full text
Hypoxia-Inducible Histone Lysine Demethylases: Impact on the Aging Process and Age-Related Diseases. / 03.2016 / PubMed / Full text

KIF1B

BDNF trafficking and signaling impairment during early neurodegeneration is prevented by moderate physical activity. / 12.2016 / PubMed / Full text
Alteration of Motor Protein Expression Involved in Bidirectional Transport in Peripheral Blood Mononuclear Cells of Patients with Amyotrophic Lateral Sclerosis. / 2016 / PubMed / Full text

KIFC3

Defective recruitment of motor proteins to autophagic compartments contributes to autophagic failure in aging. / 08.2018 / PubMed / Full text
Alteration of Motor Protein Expression Involved in Bidirectional Transport in Peripheral Blood Mononuclear Cells of Patients with Amyotrophic Lateral Sclerosis. / 2016 / PubMed / Full text

KISS1R

Kisspeptin across the human lifespan:evidence from animal studies and beyond. / 06.2016 / PubMed / Full text
Effects of Age and Estradiol on Gene Expression in the Rhesus Macaque Hypothalamus. / 2015 / PubMed / Full text

KPNA2

Karyopherin Alpha 2-Expressing Pancreatic Duct Glands and Intra-Islet Ducts in Aged Diabetic C414A-Mutant-CRY1 Transgenic Mice. / 2019 / PubMed / Full text
Upregulated Expression of Karyopherin α2 is Involved in Neuronal Apoptosis Following Intracerebral Hemorrhage in Adult Rats. / 07.2016 / PubMed / Full text

KY

Combination of acupuncture and Chinese herbal formula for elderly adults with mild cognitive impairment: protocol for a randomized controlled trial. / 11.02.2019 / PubMed / Full text
Cerebrolysin Accelerates Metamorphosis and Attenuates Aging-Accelerating Effect of High Temperature in Drosophila Melanogaster. / 01.10.2014 / PubMed / Full text

LAG3

T Cell Transcriptional Profiling and Immunophenotyping Uncover LAG3 as a Potential Significant Target of Immune Modulation in Multiple Myeloma. / 01.2020 / PubMed / Full text
Functional exhaustion of CD4 T cells induced by co-stimulatory signals from myeloid leukaemia cells. / 12.2016 / PubMed / Full text

LAMA5

The correlation of copy number variations with longevity in a genome-wide association study of Han Chinese. / 05.06.2018 / PubMed / Full text
Association of the Laminin, Alpha 5 (LAMA5) rs4925386 with height and longevity in an elderly population from Southern Italy. / 04.2016 / PubMed / Full text

LAMC1

Relation of size of seminal vesicles on ultrasound to premature ejaculation. / 09-10.2017 / PubMed / Full text
Discovery and characterization of miRNA during cellular senescence in bone marrow-derived human mesenchymal stem cells. / 10.2014 / PubMed / Full text

LAMP2

A pH probe inhibits senescence in mesenchymal stem cells. / 07.12.2018 / PubMed / Full text
Skeletal muscle from aged American Quarter Horses shows impairments in mitochondrial biogenesis and expression of autophagy markers. / 02.2018 / PubMed / Full text

LAT

Is the combined auriculotherapy approach superior to magneto-auriculotherapy alone in aging males with lower urinary tract symptoms? A randomized controlled trial. / 16.01.2019 / PubMed / Full text
Intra-couple Caregiving of Older Adults Living Apart Together: Commitment and Independence. / 09.2015 / PubMed / Full text

LATS2

[Expression relationship of Hippo signaling molecules and ovarian germline stem cell markers in the ovarian aging process of women and mice]. / 25.06.2019 / PubMed
YAP1-LATS2 feedback loop dictates senescent or malignant cell fate to maintain tissue homeostasis. / 03.2019 / PubMed / Full text

LDHA

Upregulation of lactate-inducible snail protein suppresses oncogene-mediated senescence through p16 inactivation. / 26.02.2018 / PubMed / Full text
Role of Sirtuin1-p53 regulatory axis in aging, cancer and cellular reprogramming. / 05.2018 / PubMed / Full text

LDLR

Inactivation of the E3 Ubiquitin Ligase IDOL Attenuates Diet-Induced Obesity and Metabolic Dysfunction in Mice. / 08.2018 / PubMed / Full text
Impact of age and sex on the development of atherosclerosis and expression of the related genes in apoE deficient mice. / 15.01.2016 / PubMed / Full text

LEPR

Age-related changes of leptin and leptin receptor variants in healthy elderly and long-lived adults. / 03.2015 / PubMed / Full text
Functional polymorphisms of the leptin and leptin receptor genes are associated with longevity and with the risk of myocardial infarction and of type 2 diabetes mellitus. / 2014 / PubMed / Full text

LIFR

Efficacy of leukemia inhibitory factor as a therapeutic for permanent large vessel stroke differs among aged male and female rats. / 15.03.2019 / PubMed / Full text
Characterization of Nestin-positive stem Leydig cells as a potential source for the treatment of testicular Leydig cell dysfunction. / 12.2014 / PubMed / Full text

LOXL1

A blackberry-dill extract combination synergistically increases skin elasticity. / 10.2020 / PubMed / Full text
Methylation of LOXL1 Promoter by DNMT3A in Aged Human Skin Fibroblasts. / 04.2017 / PubMed / Full text

LRP4

Multiple MuSK signaling pathways and the aging neuromuscular junction. / 13.07.2020 / PubMed / Full text
Sarcoglycan Alpha Mitigates Neuromuscular Junction Decline in Aged Mice by Stabilizing LRP4. / 10.10.2018 / PubMed / Full text

LRP5

LRP5 in age-related changes in vascular and alveolar morphogenesis in the lung. / 05.01.2019 / PubMed / Full text
Wnt1 is an Lrp5-independent bone-anabolic Wnt ligand. / 07.11.2018 / PubMed / Full text

LRPPRC

The loss of LRPPRC function induces the mitochondrial unfolded protein response. / 09.2015 / PubMed / Full text
Drosophila melanogaster LRPPRC2 is involved in coordination of mitochondrial translation. / 16.12.2014 / PubMed / Full text

LTB

Aging and Hyperglycemia Intensify Dyslipidemia-Induced Oxidative Stress and Inflammation in Rats: Assessment of Restorative Potentials of ALA and EPA DHA. / 06.2019 / PubMed / Full text
Advanced age in mares affects endometrial secretion of arachidonic acid metabolites during equine subclinical endometritis. / 11.2017 / PubMed / Full text

LTF

Uncovering genetic mechanisms of kidney aging through transcriptomics, genomics, and epigenomics. / 03.2019 / PubMed / Full text
Effect of age on long-term facilitation and chemosensitivity during NREM sleep. / 15.11.2015 / PubMed / Full text

MALT1

MALT-1 mediates IL-17 neural signaling to regulate C. elegans behavior, immunity and longevity. / 29.04.2020 / PubMed / Full text
MALT1-Deficient Mice Develop Atopic-Like Dermatitis Upon Aging. / 2019 / PubMed / Full text

MAP1A

SerThr-PhosphoProteome of Brain from Aged PINK1-KO A53T-SNCA Mice Reveals pT1928-MAP1B and pS3781-ANK2 Deficits, as Hub between Autophagy and Synapse Changes. / 04.07.2019 / PubMed / Full text
Loss of MAP function leads to hippocampal synapse loss and deficits in the Morris Water Maze with aging. / 21.05.2014 / PubMed / Full text

MAP1LC3B

The effect of aging on the autophagic and heat shock response in human peripheral blood mononuclear cells. / 01.09.2018 / PubMed / Full text
Inhibition of glioma growth by flavokawain B is mediated through endoplasmic reticulum stress induced autophagy. / 2018 / PubMed / Full text

MAP1S

Defects in MAP1S-mediated autophagy turnover of fibronectin cause renal fibrosis. / 05.2016 / PubMed / Full text
Defects in MAP1S-mediated autophagy cause reduction in mouse lifespans especially when fibronectin is overexpressed. / 04.2016 / PubMed / Full text

MARCO

Age-dependent effect between MARCO and TLR4 on PMMA particle phagocytosis by macrophages. / 08.2019 / PubMed / Full text
Aging-Impaired Filamentous Actin Polymerization Signaling Reduces Alveolar Macrophage Phagocytosis of Bacteria. / 01.11.2017 / PubMed / Full text

MAVS

Spontaneous activation of a MAVS-dependent antiviral signaling pathway determines high basal interferon-β expression in cardiac myocytes. / 10.2017 / PubMed / Full text
Progression of pathology in PINK1-deficient mouse brain from splicing via ubiquitination, ER stress, and mitophagy changes to neuroinflammation. / 02.08.2017 / PubMed / Full text

MC1R

In vitro behavior and UV response of melanocytes derived from carriers of [[CDKN2A]] mutations and MC1R variants. / 03.2019 / PubMed / Full text
The MC1R Gene and Youthful Looks. / 09.05.2016 / PubMed / Full text

MCM3

Changes in MCM2-7 proteins at senescence. / 27.07.2019 / PubMed / Full text
Up-regulation of MCM3 Relates to Neuronal Apoptosis After Traumatic Brain Injury in Adult Rats. / 05.2017 / PubMed / Full text

MCM8

Genetic variations, reproductive aging, and breast cancer risk in African American and European American women: The Women's Circle of Health Study. / 2017 / PubMed / Full text
MCM8 and MCM9 Nucleotide Variants in Women With Primary Ovarian Insufficiency. / 01.02.2017 / PubMed / Full text

MCM9

MCM8- and MCM9 Deficiencies Cause Lifelong Increased Hematopoietic DNA Damage Driving p53-Dependent Myeloid Tumors. / 10.09.2019 / PubMed / Full text
MCM8 and MCM9 Nucleotide Variants in Women With Primary Ovarian Insufficiency. / 01.02.2017 / PubMed / Full text

MDH1

Oxidative Damage to the TCA Cycle Enzyme MDH1 Dysregulates Bioenergetic Enzymatic Activity in the Aged Murine Brain. / 03.04.2020 / PubMed / Full text
Low-Dose Pesticide Mixture Induces Accelerated Mesenchymal Stem Cell Aging In Vitro. / 08.2019 / PubMed / Full text

ME1

NADP-MALIC ENZYME 1 Affects Germination after Seed Storage in Arabidopsis thaliana. / 01.02.2019 / PubMed / Full text
Down-regulation of malic enzyme 1 and 2: Sensitizing head and neck squamous cell carcinoma cells to therapy-induced senescence. / 04.2016 / PubMed / Full text

ME2

A small-molecule inhibitor suppresses the tumor-associated mitochondrial NAD(P) -dependent malic enzyme (ME2) and induces cellular senescence. / 21.08.2015 / PubMed / Full text
Down-regulation of malic enzyme 1 and 2: Sensitizing head and neck squamous cell carcinoma cells to therapy-induced senescence. / 04.2016 / PubMed / Full text

MEF2D

Molecular Pathway to Protection From Age-Dependent Photoreceptor Degeneration in Mef2 Deficiency. / 01.07.2017 / PubMed / Full text
Epigenome-wide DNA methylation in hearing ability: new mechanisms for an old problem. / 2014 / PubMed / Full text

MEIS1

Down-regulation of MEIS1 promotes the maturation of oxidative phosphorylation in perinatal cardiomyocytes. / 06.2019 / PubMed / Full text
Chronological age prediction based on DNA methylation: Massive parallel sequencing and random forest regression. / 11.2017 / PubMed / Full text

MEOX2

Reduced expression of microRNA-130a promotes endothelial cell senescence and age-dependent impairment of neovascularization. / 26.05.2020 / PubMed / Full text
Meox2 haploinsufficiency increases neuronal cell loss in a mouse model of Alzheimer's disease. / 06.2016 / PubMed / Full text

MFN1

Increased Degradation Rates in the Components of the Mitochondrial Oxidative Phosphorylation Chain in the Cerebellum of Old Mice. / 2018 / PubMed / Full text
Mitofusin 1 and optic atrophy 1 shift metabolism to mitochondrial respiration during aging. / 10.2017 / PubMed / Full text

MGAT1

Pathways of aging: comparative analysis of gene signatures in replicative senescence and stress induced premature senescence. / 28.12.2016 / PubMed / Full text
Transcriptional and biochemical responses of monoacylglycerol acyltransferase-mediated oil synthesis and associated senescence-like responses in Nicotiana benthamiana. / 2014 / PubMed / Full text

MICA

Derivation and Validation of a Geriatric-Sensitive Perioperative Cardiac Risk Index. / 16.11.2017 / PubMed / Full text
NKG2D ligands mediate immunosurveillance of senescent cells. / 02.2016 / PubMed / Full text

MKI67

Evidence for reduced neurogenesis in the aging human hippocampus despite stable stem cell markers. / 10.2017 / PubMed / Full text
[Epigenetic aspects of peptidergic regulation of vascular endothelial cell proliferation during aging]. / 2014 / PubMed

MLH1

The somatic mutation landscape of the human body. / 24.12.2019 / PubMed / Full text
RNA-Seq analysis of differentially expressed genes relevant to mismatch repair in aging hematopoietic stem-progenitor cells. / 25.02.2019 / PubMed / Full text

MNT

Application of a handheld Pressure Application Measurement device for the characterisation of mechanical nociceptive thresholds in intact pig tails. / 15.10.2016 / PubMed / Full text
Performance of the Maze Navigation Test in a sample of older New Zealanders. / 10.2015 / PubMed / Full text

MR1

Human blood MAIT cell subsets defined using MR1 tetramers. / 05.2018 / PubMed / Full text
Aging-associated formaldehyde-induced norepinephrine deficiency contributes to age-related memory decline. / 08.2015 / PubMed / Full text

MRPS5

Mutant MRPS5 affects mitoribosomal accuracy and confers stress-related behavioral alterations. / 11.2018 / PubMed / Full text
Molecular evolutionary patterns of NAD /Sirtuin aging signaling pathway across taxa. / 2017 / PubMed / Full text

MS4A6E

Association and interaction effects of Alzheimer's disease-associated genes and lifestyle on cognitive aging in older adults in a Taiwanese population. / 11.04.2017 / PubMed / Full text
Gene-based aggregate SNP associations between candidate AD genes and cognitive decline. / 04.2016 / PubMed / Full text

MSH2

RNA-Seq analysis of differentially expressed genes relevant to mismatch repair in aging hematopoietic stem-progenitor cells. / 25.02.2019 / PubMed / Full text
Age-dependent changes in DNA repair in radiation-exposed mice. / 12.2014 / PubMed / Full text

MT2A

Metallothionein Prevents Age-Associated Cardiomyopathy via Inhibiting NF-κB Pathway Activation and Associated Nitrative Damage to 2-OGD. / 10.12.2016 / PubMed / Full text
Metallothioneins and renal ageing. / 09.2016 / PubMed / Full text

MTM1

Amphiphysin 2 modulation rescues myotubular myopathy and prevents focal adhesion defects in mice. / 20.03.2019 / PubMed / Full text
Tamoxifen prolongs survival and alleviates symptoms in mice with fatal X-linked myotubular myopathy. / 19.11.2018 / PubMed / Full text

MTRR

One-carbon metabolism gene polymorphisms are associated with cognitive trajectory among African-American adults. / 12.2019 / PubMed / Full text
[Clinical and genetic characteristics of long-livers in Moscow region]. / 2013 / PubMed

MUC2

KLF4 deletion alters gastric cell lineage and induces MUC2 expression. / 09.06.2016 / PubMed / Full text
Early intestinal development and mucin transcription in the young poult with probiotic and mannan oligosaccharide prebiotic supplementation. / 05.2016 / PubMed / Full text

MYBPC3

Compound heterozygosity deteriorates phenotypes of hypertrophic cardiomyopathy with founder MYBPC3 mutation: evidence from patients and zebrafish models. / 01.12.2014 / PubMed / Full text
Association of levels of fasting glucose and insulin with rare variants at the chromosome 11p11.2-MADD locus: Cohorts for Heart and Aging Research in Genomic Epidemiology (CHARGE) Consortium Targeted Sequencing Study. / 06.2014 / PubMed / Full text

MYOD1

Low Six4 and Six5 gene dosage improves dystrophic phenotype and prolongs life span of mdx mice. / 08.2016 / PubMed / Full text
Age-associated changes in DNA methylation across multiple tissues in an inbred mouse model. / 03.2016 / PubMed / Full text

NAT2

Lifestyle and clinical determinants of skin autofluorescence in a population-based cohort study. / 05.2016 / PubMed / Full text
The ultra-slow NAT2*6A haplotype is associated with reduced higher cognitive functions in an elderly study group. / 12.2015 / PubMed / Full text

NAV2

Genetic associations with age of menopause in familial longevity. / 10.2019 / PubMed / Full text
Low expression of aging-related [[NRXN3]] is associated with Alzheimer disease: A systematic review and meta-analysis. / 07.2018 / PubMed / Full text

NBN

G protein-coupled receptor kinase 4-induced cellular senescence and its senescence-associated gene expression profiling. / 15.11.2017 / PubMed / Full text
Circulating T Cells of Patients with Nijmegen Breakage Syndrome Show Signs of Senescence. / 02.2017 / PubMed / Full text

NBR1

Nrf2 mediates the expression of BAG3 and autophagy cargo adaptor proteins and tau clearance in an age-dependent manner. / 03.2018 / PubMed / Full text
Overweight in elderly people induces impaired autophagy in skeletal muscle. / 09.2017 / PubMed / Full text

NDNF

Effect of neuron-derived neurotrophic factor on rejuvenation of human adipose-derived stem cells for cardiac repair after myocardial infarction. / 09.2019 / PubMed / Full text
Aged Human Multipotent Mesenchymal Stromal Cells Can Be Rejuvenated by Neuron-Derived Neurotrophic Factor and Improve Heart Function After Injury. / 12.2017 / PubMed / Full text

NDUFS1

Mapping the protein phosphorylation sites in human mitochondrial complex I (NADH: Ubiquinone oxidoreductase): A bioinformatics study with implications for brain aging and neurodegeneration. / 01.2019 / PubMed / Full text
Contribution of genetic polymorphisms on functional status at very old age: a gene-based analysis of 38 genes (311 SNPs) in the oxidative stress pathway. / 04.2014 / PubMed / Full text

NDUFV2

Low expression of aging-related [[NRXN3]] is associated with Alzheimer disease: A systematic review and meta-analysis. / 07.2018 / PubMed / Full text
The Effect of Aging on Mitochondrial Complex I and the Extent of Oxidative Stress in the Rat Brain Cortex. / 08.2016 / PubMed / Full text

NECTIN2

Genetics of Human Longevity From Incomplete Data: New Findings From the Long Life Family Study. / 08.10.2018 / PubMed / Full text
Apolipoprotein E region molecular signatures of Alzheimer's disease. / 08.2018 / PubMed / Full text

NEFM

Changes in mechanoreceptors in rabbits' anterior cruciate ligaments with age. / 06.2019 / PubMed / Full text
The Alzheimer's disease transcriptome mimics the neuroprotective signature of IGF-1 receptor-deficient neurons. / 01.07.2017 / PubMed / Full text

NEIL1

NEIL1 stimulates neurogenesis and suppresses neuroinflammation after stress. / 09.2019 / PubMed / Full text
Neil2-null Mice Accumulate Oxidized DNA Bases in the Transcriptionally Active Sequences of the Genome and Are Susceptible to Innate Inflammation. / 09.10.2015 / PubMed / Full text

NEO1

Neogenin-1 distinguishes between myeloid-biased and balanced [i]Hoxb5[/i] mouse long-term hematopoietic stem cells. / 10.12.2019 / PubMed / Full text
Ionizing radiation reduces ADAM10 expression in brain microvascular endothelial cells undergoing stress-induced senescence. / 04.2017 / PubMed / Full text

NFATC1

Age-dependent human β cell proliferation induced by glucagon-like peptide 1 and calcineurin signaling. / 02.10.2017 / PubMed / Full text
Genome-wide methylation analysis reveals differentially methylated loci that are associated with an age-dependent increase in bovine fibroblast response to LPS. / 25.05.2017 / PubMed / Full text

NFIB

Cell-type-specific expression of NFIX in the developing and adult cerebellum. / 07.2017 / PubMed / Full text
Multipotency of Adult Hippocampal NSCs In Vivo Is Restricted by Drosha/NFIB. / 03.11.2016 / PubMed / Full text

NGFR

Evidence for changing nerve growth factor signalling mechanisms during development, maturation and ageing in the rat molar pulp. / 02.2019 / PubMed / Full text
A nutrigenomics approach for the study of anti-aging interventions: olive oil phenols and the modulation of gene and microRNA expression profiles in mouse brain. / 03.2017 / PubMed / Full text

NHLRC1

DNA methylation-based forensic age prediction using artificial neural networks and next generation sequencing. / 05.2017 / PubMed / Full text
Loss of GABAergic cortical neurons underlies the neuropathology of Lafora disease. / 28.01.2014 / PubMed / Full text

NLRP1

NADPH oxidase 2-mediated NLRP1 inflammasome activation involves in neuronal senescence in hippocampal neurons in vitro. / 04.2019 / PubMed / Full text
Genetic analysis of long-lived families reveals novel variants influencing high density-lipoprotein cholesterol. / 2014 / PubMed / Full text

NLRP12

Persistent DNA damage-induced NLRP12 improves hematopoietic stem cell function. / 21.05.2020 / PubMed / Full text
Effects of aging in the expression of NOD-like receptors and inflammasome-related genes in oral mucosa. / 02.2016 / PubMed / Full text

NLRX1

NOD-like receptor X1 functions as a tumor suppressor by inhibiting epithelial-mesenchymal transition and inducing aging in hepatocellular carcinoma cells. / 26.02.2018 / PubMed / Full text
The expression of NLRX1 in C57BL/6 mice cochlear hair cells: Possible relation to aging- and neomycin-induced deafness. / 11.03.2016 / PubMed / Full text

NMB

Characterizing Heterogeneity Bias in Cohort-Based Models. / 08.2015 / PubMed / Full text
Asleep versus awake: does it matter?: Pediatric regional block complications by patient state: a report from the Pediatric Regional Anesthesia Network. / 07-08.2014 / PubMed / Full text

NME8

Association and interaction effects of Alzheimer's disease-associated genes and lifestyle on cognitive aging in older adults in a Taiwanese population. / 11.04.2017 / PubMed / Full text
Gene-based aggregate SNP associations between candidate AD genes and cognitive decline. / 04.2016 / PubMed / Full text

NMNAT1

ADNP differentially interact with genes/proteins in correlation with aging: a novel marker for muscle aging. / 06.2019 / PubMed / Full text
Genome-wide association study and annotating candidate gene networks affecting age at first calving in Nellore cattle. / 12.2017 / PubMed / Full text

NMNAT2

NMNAT2-mediated NAD generation is essential for quality control of aged oocytes. / 06.2019 / PubMed / Full text
Sarm1 Deletion, but Not Wld , Confers Lifelong Rescue in a Mouse Model of Severe Axonopathy. / 03.10.2017 / PubMed / Full text

NMS

Uncontrolled Diabetes as an Associated Factor with Dynapenia in Adults Aged 50 Years or Older: Sex Differences. / 22.05.2020 / PubMed / Full text
Neonatal stress affects the aging trajectory of female rats on the endocrine, temperature, and ventilatory responses to hypoxia. / 01.04.2015 / PubMed / Full text

NNMT

Small molecule nicotinamide N-methyltransferase inhibitor activates senescent muscle stem cells and improves regenerative capacity of aged skeletal muscle. / 05.2019 / PubMed / Full text
Nicotinamide-N-methyltransferase controls behavior, neurodegeneration and lifespan by regulating neuronal autophagy. / 09.2018 / PubMed / Full text

NONO

Physiological levels of thrombospondin-1 decrease NO-dependent vasodilation in coronary microvessels from aged rats. / 01.06.2016 / PubMed / Full text
The effects of aging on the functional and structural properties of the rat basilar artery. / 01.06.2014 / PubMed / Full text

NOP10

Pseudouridylation defect due to [i]DKC1[/i] and [i]NOP10[/i] mutations causes nephrotic syndrome with cataracts, hearing impairment, and enterocolitis. / 30.06.2020 / PubMed / Full text
Acute telomerase components depletion triggers oxidative stress as an early event previous to telomeric shortening. / 04.2018 / PubMed / Full text

NPAS2

Is the aging human ovary still ticking?: Expression of clock-genes in luteinized granulosa cells of young and older women. / 21.11.2018 / PubMed / Full text
Effects of circadian clock genes and environmental factors on cognitive aging in old adults in a Taiwanese population. / 11.04.2017 / PubMed / Full text

NPTX2

Evaluation of DNA methylation markers and their potential to predict human aging. / 08.2015 / PubMed / Full text
Developing a DNA methylation assay for human age prediction in blood and bloodstain. / 07.2015 / PubMed / Full text

NPW

Novel information processing at work across time is associated with cognitive change in later life: A 14-year longitudinal study. / 09.2020 / PubMed / Full text
Neuropeptide W modulation of gastric vagal afferent mechanosensitivity: Impact of age and sex. / 09.2015 / PubMed / Full text

NR3C1

Glucocorticoid receptor (NR3C1) gene polymorphisms are associated with age and blood parameters in Polish Caucasian nonagenarians and centenarians. / 02.2019 / PubMed / Full text
Inter-Regional Variations in Gene Expression and Age-Related Cortical Thinning in the Adolescent Brain. / 01.04.2018 / PubMed / Full text

NR4A2

The NR4A nuclear receptors as potential targets for anti-aging interventions. / 02.2015 / PubMed / Full text
Comparative pathway and network analysis of brain transcriptome changes during adult aging and in Parkinson's disease. / 02.2015 / PubMed / Full text

NRM

Association between Clonal Hematopoiesis and Late Nonrelapse Mortality after Autologous Hematopoietic Cell Transplantation. / 12.2019 / PubMed / Full text
NRMT1 knockout mice exhibit phenotypes associated with impaired DNA repair and premature aging. / 03.2015 / PubMed / Full text

NRXN1

Neurexins 1-3 Each Have a Distinct Pattern of Expression in the Early Developing Human Cerebral Cortex. / 01.01.2017 / PubMed / Full text
Neurexin 1 ([[NRXN1]]) splice isoform expression during human neocortical development and aging. / 05.2016 / PubMed / Full text

NRXN3

Low expression of aging-related [[NRXN3]] is associated with Alzheimer disease: A systematic review and meta-analysis. / 07.2018 / PubMed / Full text
Neurexins 1-3 Each Have a Distinct Pattern of Expression in the Early Developing Human Cerebral Cortex. / 01.01.2017 / PubMed / Full text

NTF4

Subcutaneous Neurotrophin 4 Infusion Using Osmotic Pumps or Direct Muscular Injection Enhances Aging Rat Laryngeal Muscles. / 13.06.2017 / PubMed / Full text
Enhancement of aging rat laryngeal muscles with endogenous growth factor treatment. / 05.2016 / PubMed / Full text

OAT

Opioid agonist treatment reduces losses in quality of life and quality-adjusted life expectancy in heroin users: Evidence from real world data. / 01.08.2019 / PubMed / Full text
Strength training and aerobic exercise alter mitochondrial parameters in brown adipose tissue and equally reduce body adiposity in aged rats. / 02.2019 / PubMed / Full text

OGA

NPGPx-Mediated Adaptation to Oxidative Stress Protects Motor Neurons from Degeneration in Aging by Directly Modulating O-GlcNAcase. / 19.11.2019 / PubMed / Full text
Aging leads to elevation of O-GlcNAcylation and disruption of mitochondrial homeostasis in retina. / 2014 / PubMed / Full text

PAPSS2

Autosomal recessive brachyolmia: early radiological findings. / 11.2016 / PubMed / Full text
Gene Expression Differences Between Offspring of Long-Lived Individuals and Controls in Candidate Longevity Regions: Evidence for PAPSS2 as a Longevity Gene. / 10.2016 / PubMed / Full text

PAX5

Diminished antibody response to influenza vaccination is characterized by expansion of an age-associated B-cell population with low PAX5. / 08.2018 / PubMed / Full text
Developmental expression of B cell molecules in equine lymphoid tissues. / 01.2017 / PubMed / Full text

PAX6

Pbx1 is required for adult subventricular zone neurogenesis. / 01.07.2016 / PubMed / Full text
Epigenetic mechanisms of peptidergic regulation of gene expression during aging of human cells. / 03.2015 / PubMed / Full text

PBX1

Internalization of the TAT-PBX1 fusion protein significantly enhances the proliferation of human hair follicle-derived mesenchymal stem cells and delays their senescence. / 10.2020 / PubMed / Full text
Pbx1 is required for adult subventricular zone neurogenesis. / 01.07.2016 / PubMed / Full text

PCDH10

Genome-Wide Association Analysis of the Sense of Smell in U.S. Older Adults: Identification of Novel Risk Loci in African-Americans and European-Americans. / 12.2017 / PubMed / Full text
PCDH10, a novel p53 transcriptional target in regulating cell migration. / 2015 / PubMed / Full text

PDCD4

Petal abscission in roses is associated with the activation of a truncated version of the animal PDCD4 homologue, RbPCD1. / 11.2019 / PubMed / Full text
PDCD4 Knockdown Induces Senescence in Hepatoma Cells by Up-Regulating the p21 Expression. / 2018 / PubMed / Full text

PDE10A

Cyclic nucleotide signaling changes associated with normal aging and age-related diseases of the brain. / 01.2018 / PubMed / Full text
Patterns of age related changes for phosphodiesterase type-10A in comparison with dopamine D receptors and sub-cortical volumes in the human basal ganglia: A PET study with F-MNI-659 and C-raclopride with correction for partial volume effect. / 15.05.2017 / PubMed / Full text

PDE1A

Phosphodiesterase 1 regulation is a key mechanism in vascular aging. / 12.2015 / PubMed / Full text
Cyclic nucleotide phosphodiesterase 1 and vascular aging. / 12.2015 / PubMed / Full text

PDE1C

Phosphodiesterase 1 regulation is a key mechanism in vascular aging. / 12.2015 / PubMed / Full text
Cyclic nucleotide phosphodiesterase 1 and vascular aging. / 12.2015 / PubMed / Full text

PDE4B

Phosphodiesterase-4B as a Therapeutic Target for Cognitive Impairment and Obesity-Related Metabolic Diseases. / 2017 / PubMed / Full text
The isozyme selective phosphodiesterase-4 inhibitor, ABI-4, attenuates the effects of lipopolysaccharide in human cells and rodent models of peripheral and CNS inflammation. / 08.2017 / PubMed / Full text

PDGFB

Skin-resident stem cells and wound healing. / 2017 / PubMed / Full text
The choroid plexus transcriptome reveals changes in type I and II interferon responses in a mouse model of Alzheimer's disease. / 10.2015 / PubMed / Full text

PDGFRB

A tyrosine kinase-activating variant Asn666Ser in PDGFRB causes a progeria-like condition in the severe end of Penttinen syndrome. / 04.2019 / PubMed / Full text
Expansion of the phenotype of Kosaki overgrowth syndrome. / 09.2017 / PubMed / Full text

PDK2

Age-related impairments in skeletal muscle PDH phosphorylation and plasma lactate are indicative of metabolic inflexibility and the effects of exercise training. / 01.07.2016 / PubMed / Full text
Effects of Exercise Training on Regulation of Skeletal Muscle Glucose Metabolism in Elderly Men. / 07.2015 / PubMed / Full text

PDK4

Putrescine delays postovulatory aging of mouse oocytes by upregulating PDK4 expression and improving mitochondrial activity. / 16.12.2018 / PubMed / Full text
Age-related impairments in skeletal muscle PDH phosphorylation and plasma lactate are indicative of metabolic inflexibility and the effects of exercise training. / 01.07.2016 / PubMed / Full text

PDX1

Resveratrol attenuates senescence of adipose-derived mesenchymal stem cells and restores their paracrine effects on promoting insulin secretion of INS-1 cells through Pim-1. / 2016 / PubMed
Epigenetic mechanisms of peptidergic regulation of gene expression during aging of human cells. / 03.2015 / PubMed / Full text

PENK

Aging-associated DNA methylation changes in middle-aged individuals: the Young Finns study. / 09.02.2016 / PubMed / Full text
Genome-wide age-related changes in DNA methylation and gene expression in human PBMCs. / 06.2014 / PubMed / Full text

PES1

Transcription factor RD26 is a key regulator of metabolic reprogramming during dark-induced senescence. / 06.2018 / PubMed / Full text
The Plastoglobule-Localized Metallopeptidase PGM48 Is a Positive Regulator of Senescence in Arabidopsis thaliana. / 12.2016 / PubMed / Full text

PFKFB3

DNA damage, metabolism and aging in pro-inflammatory T cells: Rheumatoid arthritis as a model system. / 05.2018 / PubMed / Full text
Bioenergetic mechanisms in astrocytes may contribute to amyloid plaque deposition and toxicity. / 15.05.2015 / PubMed / Full text

PGD

Primary Care for the Elderly Bereaved: Recommendations for Medical Education. / 12.2018 / PubMed / Full text
High percentages of embryos with 21, 18 or 13 trisomy are related to advanced paternal age in donor egg cycles. / 01.03.2018 / PubMed / Full text

PGR

Inter-Regional Variations in Gene Expression and Age-Related Cortical Thinning in the Adolescent Brain. / 01.04.2018 / PubMed / Full text
Effects of Age and Estradiol on Gene Expression in the Rhesus Macaque Hypothalamus. / 2015 / PubMed / Full text

PHB2

Prohibitin-2 is a novel regulator of p21 induced by depletion of γ-glutamylcyclotransferase. / 29.01.2018 / PubMed / Full text
Prohibitin 2 Is an Inner Mitochondrial Membrane Mitophagy Receptor. / 12.01.2017 / PubMed / Full text

PI4KB

Differential DNA Methylation in Relation to Age and Health Risks of Obesity. / 24.07.2015 / PubMed / Full text
Coordinated Expression of Phosphoinositide Metabolic Genes during Development and Aging of Human Dorsolateral Prefrontal Cortex. / 2015 / PubMed / Full text

PIEZO1

Niche stiffness underlies the ageing of central nervous system progenitor cells. / 09.2019 / PubMed / Full text
On the Mechanism of Human Red Blood Cell Longevity: Roles of Calcium, the Sodium Pump, PIEZO1, and Gardos Channels. / 2017 / PubMed / Full text

PIK3R2

The senescent status of endothelial cells affects proliferation, inflammatory profile and SOX2 expression in bone marrow-derived mesenchymal stem cells. / 06.2019 / PubMed / Full text
Gene transcripts associated with muscle strength: a CHARGE meta-analysis of 7,781 persons. / 01.2016 / PubMed / Full text

PLA2G6

Mutations in the Drosophila homolog of human PLA2G6 give rise to age-dependent loss of psychomotor activity and neurodegeneration. / 13.02.2018 / PubMed / Full text
iPLA2β knockout mouse, a genetic model for progressive human motor disorders, develops age-related neuropathology. / 08.2014 / PubMed / Full text

PLA2R1

Targeting the phospholipase A2 receptor ameliorates premature aging phenotypes. / 12.2018 / PubMed / Full text
PLA2R1: expression and function in cancer. / 08.2014 / PubMed / Full text

PLD3

Whole-Exome Sequencing of an Exceptional Longevity Cohort. / 16.08.2019 / PubMed / Full text
Association and interaction effects of Alzheimer's disease-associated genes and lifestyle on cognitive aging in older adults in a Taiwanese population. / 11.04.2017 / PubMed / Full text

PLK4

A novel lncRNA PLK4 up-regulated by talazoparib represses hepatocellular carcinoma progression by promoting YAP-mediated cell senescence. / 05.2020 / PubMed / Full text
Differential expression of AURKA/PLK4 in quiescence and senescence of osteosarcoma U2OS cells. / 04.2020 / PubMed / Full text

POLD3

POLD3 Is Haploinsufficient for DNA Replication in Mice. / 01.09.2016 / PubMed / Full text
POLD1: Central mediator of DNA replication and repair, and implication in cancer and other pathologies. / 15.09.2016 / PubMed / Full text

POLG2

An N-Ethyl-N-Nitrosourea (ENU)-Induced Tyr265Stop Mutation of the DNA Polymerase Accessory Subunit Gamma 2 (Polg2) Is Associated With Renal Calcification in Mice. / 03.2019 / PubMed / Full text
Genome wide association and linkage analyses identified three loci-4q25, 17q23.2, and 10q11.21-associated with variation in leukocyte telomere length: the Long Life Family Study. / 2013 / PubMed / Full text

PPARD

[[PPARD]] 294C overrepresentation in general and long-lived population in China Bama longevity area and unique relationships between [[PPARD]] 294T/C polymorphism and serum lipid profiles. / 07.03.2015 / PubMed / Full text
[Genotype and allele frequencies of UCP and PPAR gene families in residents of besieged Leningrad and in the control group]. / 2014 / PubMed

PPM1D

Detectible mosaic truncating PPM1D mutations, age and breast cancer risk. / 06.2019 / PubMed / Full text
Age-related remodelling of oesophageal epithelia by mutated cancer drivers. / 01.2019 / PubMed / Full text

PPY

Delta Cell Hyperplasia in Adult Goto-Kakizaki (GK/MolTac) Diabetic Rats. / 2015 / PubMed / Full text
Blood Protein Markers of Neocortical Amyloid-β Burden: A Candidate Study Using SOMAscan Technology. / 2015 / PubMed / Full text

PRDM16

Assessment of the Aging of the Brown Adipose Tissue by F-FDG PET/CT Imaging in the Progeria Mouse Model Lmna . / 2018 / PubMed / Full text
Large-scale analysis reveals a functional single-nucleotide polymorphism in the 5'-flanking region of PRDM16 gene associated with lean body mass. / 08.2014 / PubMed / Full text

PRF1

Gene transcripts associated with muscle strength: a CHARGE meta-analysis of 7,781 persons. / 01.2016 / PubMed / Full text
Gene expression markers of age-related inflammation in two human cohorts. / 10.2015 / PubMed / Full text

PRMT5

Regenerating muscle with arginine methylation. / 27.05.2017 / PubMed / Full text
Simultaneous ablation of prmt-1 and prmt-5 abolishes asymmetric and symmetric arginine dimethylations in Caenorhabditis elegans. / 01.06.2017 / PubMed / Full text

PRMT7

Regenerating muscle with arginine methylation. / 27.05.2017 / PubMed / Full text
PRMT7 Preserves Satellite Cell Regenerative Capacity. / 16.02.2016 / PubMed / Full text

PRMT8

Arginine Methyltransferase PRMT8 Provides Cellular Stress Tolerance in Aging Motoneurons. / 29.08.2018 / PubMed / Full text
Novel Protein Arginine Methyltransferase 8 Isoform Is Essential for Cell Proliferation. / 09.2016 / PubMed / Full text

PRNP

Spontaneous generation of prions and transmissible PrP amyloid in a humanised transgenic mouse model of A117V GSS. / 06.2020 / PubMed / Full text
AGE AND REPEATED BIOPSY INFLUENCE ANTEMORTEM PRP(CWD) TESTING IN MULE DEER (ODOCOILEUS HEMIONUS) IN COLORADO, USA. / 10.2015 / PubMed / Full text

PTBP1

Dual functions for OVAAL in initiation of RAF/MEK/ERK prosurvival signals and evasion of p27-mediated cellular senescence. / 11.12.2018 / PubMed / Full text
PTBP1-Mediated Alternative Splicing Regulates the Inflammatory Secretome and the Pro-tumorigenic Effects of Senescent Cells. / 09.07.2018 / PubMed / Full text

PTH1R

Bone-remodeling transcript levels are independent of perching in end-of-lay white leghorn chickens. / 23.01.2015 / PubMed / Full text
Variation in the [[PTH2R]] gene is associated with age-related degenerative changes in the lumbar spine. / 01.2015 / PubMed / Full text

PUM2

PUMILIO hyperactivity drives premature aging of [i]Norad[/i]-deficient mice. / 08.02.2019 / PubMed / Full text
The RNA-Binding Protein PUM2 Impairs Mitochondrial Dynamics and Mitophagy During Aging. / 21.02.2019 / PubMed / Full text

PYCR1

A Transcriptome Study of Progeroid Neurocutaneous Syndrome Reveals POSTN As a New Element in Proline Metabolic Disorder. / 12.2018 / PubMed / Full text
Sublethal endoplasmic reticulum stress caused by the mutation of immunoglobulin heavy chain-binding protein induces the synthesis of a mitochondrial protein, pyrroline-5-carboxylate reductase 1. / 01.2017 / PubMed / Full text

RAC1

Reactive oxygen species: The good, the bad, and the enigma. / 07-09.2014 / PubMed / Full text
NADPH oxidase-derived production of reactive oxygen species is involved in learning and memory impairments in 16-month-old female rats. / 09.2015 / PubMed / Full text

RAF1

Circular [i]ANRIL[/i] isoforms switch from repressors to activators of [i]p15/CDKN2B[/i] expression during RAF1 oncogene-induced senescence. / 29.09.2020 / PubMed / Full text
MSK1 triggers the expression of the INK4AB/ARF locus in oncogene-induced senescence. / 01.09.2016 / PubMed / Full text

RAG1

T cell senescence accelerates Angiotensin II-induced target organ damage. / 12.02.2020 / PubMed / Full text
Aged murine hematopoietic stem cells drive aging-associated immune remodeling. / 09.08.2018 / PubMed / Full text

RAG2

Phosphate Transporter Profiles in Murine and Human Thymi Identify Thymocytes at Distinct Stages of Differentiation. / 2020 / PubMed / Full text
Both retention and recirculation contribute to long-lived regulatory T-cell accumulation in the thymus. / 09.2014 / PubMed / Full text

RECQL5

RECQL5 has unique strand annealing properties relative to the other human RecQ helicase proteins. / 01.2016 / PubMed / Full text
Senescence induced by RECQL4 dysfunction contributes to Rothmund-Thomson syndrome features in mice. / 15.05.2014 / PubMed / Full text

RELA

Genome-wide association study and annotating candidate gene networks affecting age at first calving in Nellore cattle. / 12.2017 / PubMed / Full text
The Inflammatory Transcription Factors NFκB, STAT1 and STAT3 Drive Age-Associated Transcriptional Changes in the Human Kidney. / 12.2015 / PubMed / Full text

RIPK2

RIP kinases as modulators of inflammation and immunity. / 09.2018 / PubMed / Full text
Molecular modeling in the age of clinical genomics, the enterprise of the next generation. / 03.2017 / PubMed / Full text

RPIA

Suppression of p16 Induces mTORC1-Mediated Nucleotide Metabolic Reprogramming. / 20.08.2019 / PubMed / Full text
Ribose-5-phosphate isomerase A regulates hepatocarcinogenesis via PP2A and ERK signaling. / 01.07.2015 / PubMed / Full text

RPS6

Regulation of Amino Acid Transporters and Sensors in Response to a High protein Diet: A Randomized Controlled Trial in Elderly Men. / 2019 / PubMed / Full text
Endothelial replicative senescence delayed by the inhibition of MTORC1 signaling involves MicroRNA-107. / 08.2018 / PubMed / Full text

RRM1

α-Synuclein toxicity in yeast and human cells is caused by cell cycle re-entry and autophagy degradation of ribonucleotide reductase 1. / 08.2019 / PubMed / Full text
GBM-associated mutations and altered protein expression are more common in young patients. / 25.10.2016 / PubMed / Full text

RTEL1

Telomere length and aging-related outcomes in humans: A Mendelian randomization study in 261,000 older participants. / 12.2019 / PubMed / Full text
Genome-wide association study of telomere length among South Asians identifies a second RTEL1 association signal. / 01.2018 / PubMed / Full text

S100A12

Fetal articular cartilage regeneration versus adult fibrocartilaginous repair: secretome proteomics unravels molecular mechanisms in an ovine model. / 06.07.2018 / PubMed / Full text
Evaluation of serum biochemical marker concentrations and survival time in dogs with protein-losing enteropathy. / 01.01.2015 / PubMed / Full text

S100A4

Protective role of mesenchymal stem cells and mesenchymal stem cell-derived exosomes in cigarette smoke-induced mitochondrial dysfunction in mice. / 15.12.2019 / PubMed / Full text
Tissue Taurine Depletion Induces Profibrotic Pattern of Gene Expression and Causes Aging-Related Cardiac Fibrosis in Heart in Mice. / 2018 / PubMed / Full text

S1PR3

Sexual dimorphism of metabolic and vascular dysfunction in aged mice and those lacking the sphingosine 1-phosphate receptor 3. / 01.12.2017 / PubMed / Full text
Impact of Age and Polytherapy on Fingolimod Induced Bradycardia: a Preclinical Study. / 03.2017 / PubMed / Full text

SAA1

Naturally occurring antibodies against serum amyloid A reduce IL-6 release from peripheral blood mononuclear cells. / 2018 / PubMed / Full text
Association between local inflammation and breast tissue age-related lobular involution among premenopausal and postmenopausal breast cancer patients. / 2017 / PubMed / Full text

SALL1

SALL1 functions as a tumor suppressor in breast cancer by regulating cancer cell senescence and metastasis through the NuRD complex. / 06.04.2018 / PubMed / Full text
Genome-Wide Association Analysis of the Sense of Smell in U.S. Older Adults: Identification of Novel Risk Loci in African-Americans and European-Americans. / 12.2017 / PubMed / Full text

SCGN

Detection and evaluation of DNA methylation markers found at SCGN and KLF14 loci to estimate human age. / 11.2017 / PubMed / Full text
DNA methylation-based forensic age prediction using artificial neural networks and next generation sequencing. / 05.2017 / PubMed / Full text

SCN2B

MicroRNA‑449a regulates the progression of brain aging by targeting SCN2B in SAMP8 mice. / 04.2020 / PubMed / Full text
Sodium Channel Voltage-Gated Beta 2 Plays a Vital Role in Brain Aging Associated with Synaptic Plasticity and Expression of COX5A and FGF-2. / 03.2016 / PubMed / Full text

SCN5A

[Use of Pharmacogenetic Information for Therapeutic Drug Monitoring of an Antiarrhythmic Drug]. / 2018 / PubMed / Full text
Sequencing of SCN5A identifies rare and common variants associated with cardiac conduction: Cohorts for Heart and Aging Research in Genomic Epidemiology (CHARGE) Consortium. / 06.2014 / PubMed / Full text

SDC4

Alterations in Corneal Sensory Nerves During Homeostasis, Aging, and After Injury in Mice Lacking the Heparan Sulfate Proteoglycan Syndecan-1. / 01.10.2017 / PubMed / Full text
Metabolism and successful aging: Polymorphic variation of syndecan-4 (SDC4) gene associate with longevity and lipid profile in healthy elderly Italian subjects. / 09.2015 / PubMed / Full text

SDHA

Accumulation of electrophilic aldehydes during postovulatory aging of mouse oocytes causes reduced fertility, oxidative stress, and apoptosis. / 02.2015 / PubMed / Full text
Effect of testosterone on markers of mitochondrial oxidative phosphorylation and lipid metabolism in muscle of aging men with subnormal bioavailable testosterone. / 07.2014 / PubMed / Full text

SDHB

Mitochondrial Signatures in Circulating Extracellular Vesicles of Older Adults with Parkinson's Disease: Results from the EXosomes in PArkiNson's Disease (EXPAND) Study. / 12.02.2020 / PubMed / Full text
Mitochondrial bioenergetics and disease in Caenorhabditis elegans. / 01.01.2015 / PubMed / Full text

SESN2

Copy Number Alterations in Papillary Thyroid Carcinomas: Does Loss of [i]SESN2[/i] Have a Role in Age-related Different Prognoses? / 09-10.2020 / PubMed / Full text
Loss of sestrin 2 potentiates the early onset of age-related sensory cell degeneration in the cochlea. / 11.10.2017 / PubMed / Full text

SESN3

Autophagy mediators (FOXO1, SESN3 and TSC2) in Lewy body disease and aging. / 25.09.2018 / PubMed / Full text
Age-related reduction in the expression of FOXO transcription factors and correlations with intervertebral disc degeneration. / 12.2017 / PubMed / Full text

SF3B1

Leukemia-associated somatic mutations drive distinct patterns of age-related clonal hemopoiesis. / 03.03.2015 / PubMed / Full text
Splicing factor 3B1 hypomethylation is associated with altered SF3B1 transcript expression in older humans. / 01.2014 / PubMed / Full text

SFRP2

[Role and alterations of DNA methylation during the aging and cancer]. / 01.2018 / PubMed / Full text
Thyroid hormone activates Wnt/β-catenin signaling involved in adult epithelial development during intestinal remodeling in Xenopus laevis. / 08.2016 / PubMed / Full text

SHANK3

Spontaneous seizure and partial lethality of juvenile Shank3-overexpressing mice in C57BL/6 J background. / 10.10.2018 / PubMed / Full text
Adult restoration of Shank3 expression rescues selective autistic-like phenotypes. / 25.02.2016 / PubMed / Full text

SHB

Longitudinal Relationships between Reproductive Hormones and Cognitive Decline in Older Men: The Concord Health and Ageing in Men Project. / 06.2015 / PubMed / Full text
'Carriers of variant luteinizing hormone (V-LH) among 1593 Baltic men have significantly higher serum LH'. / 05.2015 / PubMed / Full text

SIX3

CellBIC: bimodality-based top-down clustering of single-cell RNA sequencing data reveals hierarchical structure of the cell type. / 30.11.2018 / PubMed / Full text
Age-Dependent Pancreatic Gene Regulation Reveals Mechanisms Governing Human β Cell Function. / 10.05.2016 / PubMed / Full text

SLC13A5

INDY-A New Link to Metabolic Regulation in Animals and Humans. / 2017 / PubMed / Full text
The role of INDY in metabolism, health and longevity. / 2015 / PubMed / Full text

SLC19A1

Novel drug-resistance mechanisms of pemetrexed-treated non-small cell lung cancer. / 30.03.2018 / PubMed / Full text
Association of MTHFR, SLC19A1 Genetic Polymorphism, Serum Folate, Vitamin B and Hcy Status with Cognitive Functions in Chinese Adults. / 24.10.2016 / PubMed / Full text

SLC24A4

Association and interaction effects of Alzheimer's disease-associated genes and lifestyle on cognitive aging in older adults in a Taiwanese population. / 11.04.2017 / PubMed / Full text
Gene-based aggregate SNP associations between candidate AD genes and cognitive decline. / 04.2016 / PubMed / Full text

SLC25A24

De Novo Mutations in SLC25A24 Cause a Disorder Characterized by Early Aging, Bone Dysplasia, Characteristic Face, and Early Demise. / 02.11.2017 / PubMed / Full text
De Novo Mutations in SLC25A24 Cause a Craniosynostosis Syndrome with Hypertrichosis, Progeroid Appearance, and Mitochondrial Dysfunction. / 02.11.2017 / PubMed / Full text

SLC6A3

A variable number of tandem repeats in the 3'-untranslated region of the dopamine transporter modulates striatal function during working memory updating across the adult age span. / 08.2015 / PubMed / Full text
Effects of Age and Estradiol on Gene Expression in the Rhesus Macaque Hypothalamus. / 2015 / PubMed / Full text

SLC7A11

SOCS1 regulates senescence and ferroptosis by modulating the expression of p53 target genes. / 28.10.2017 / PubMed / Full text
Comprehensive Analysis of Interaction Networks of Telomerase Reverse Transcriptase with Multiple Bioinformatic Approaches: Deep Mining the Potential Functions of Telomere and Telomerase. / 08.2017 / PubMed / Full text

SLN

Completion Lymph Node Dissection or Observation for Melanoma Sentinel Lymph Node Metastases: A Decision Analysis. / 09.2016 / PubMed / Full text
Age differences in brain activity related to unsuccessful declarative memory retrieval. / 01.07.2015 / PubMed / Full text

SMAD1

TGFB1-Mediated Gliosis in Multiple Sclerosis Spinal Cords Is Favored by the Regionalized Expression of HOXA5 and the Age-Dependent Decline in Androgen Receptor Ligands. / 26.11.2019 / PubMed / Full text
BMP-SMAD-ID promotes reprogramming to pluripotency by inhibiting p16/INK4A-dependent senescence. / 15.11.2016 / PubMed / Full text

SMAD7

Forkhead Box Protein 1 (FoxO1) Inhibits Accelerated β Cell Aging in Pancreas-specific SMAD7 Mutant Mice. / 24.02.2017 / PubMed / Full text
Granulosa cell function and oocyte competence: Super-follicles, super-moms and super-stimulation in cattle. / 09.2014 / PubMed / Full text

SMO

Sonic hedgehog regulation of cavernous nerve regeneration and neurite formation in aged pelvic plexus. / 02.2019 / PubMed / Full text
Silybum marianum oil attenuates oxidative stress and ameliorates mitochondrial dysfunction in mice treated with D-galactose. / 01.2014 / PubMed / Full text

SMOX

Skeletal Muscle Pathophysiology: The Emerging Role of Spermine Oxidase and Spermidine. / 14.02.2018 / PubMed / Full text
Haemocytes control stem cell activity in the Drosophila intestine. / 06.2015 / PubMed / Full text

SNCB

Age-related distribution and potential role of SNCB in topographically different retinal areas of the common marmoset Callithrix jacchus, including the macula. / 08.2019 / PubMed / Full text
Age-related Beta-synuclein Alters the p53/Mdm2 Pathway and Induces the Apoptosis of Brain Microvascular Endothelial Cells In Vitro. / 05.2018 / PubMed / Full text

SOCS2

Suppressor of Cytokine Signalling 2 (SOCS2) Regulates Numbers of Mature Newborn Adult Hippocampal Neurons and Their Dendritic Spine Maturation. / 07.2017 / PubMed / Full text
Age-independent effects of hyaluronan amide derivative and growth hormone on human osteoarthritic chondrocytes. / 11.2015 / PubMed / Full text

SPARCL1

Specific factors in blood from young but not old mice directly promote synapse formation and NMDA-receptor recruitment. / 18.06.2019 / PubMed / Full text
SPARCL1 Accelerates Symptom Onset in Alzheimer's Disease and Influences Brain Structure and Function During Aging. / 2018 / PubMed / Full text

SPON1

APOE influences working memory in non-demented elderly through an interaction with SPON1 rs2618516. / 07.2018 / PubMed / Full text
HYDRA: Revealing heterogeneity of imaging and genetic patterns through a multiple max-margin discriminative analysis framework. / 15.01.2017 / PubMed / Full text

SRR

Mediterranean diet and its components in relation to all-cause mortality: meta-analysis. / 11.2018 / PubMed / Full text
Genetic Biomarkers on Age-Related Cognitive Decline. / 2017 / PubMed / Full text

SRY

Identification of novel genes in aging osteoblasts using next-generation sequencing and bioinformatics. / 26.12.2017 / PubMed / Full text
Regulation of senescence associated signaling mechanisms in chondrocytes for cartilage tissue regeneration. / 02.2016 / PubMed / Full text

SSTR1

Expression and localization of somatostatin receptor types 3, 4 and 5 in the wild-type, SSTR1 and SSTR1/SSTR2 knockout mouse cochlea. / 12.2014 / PubMed / Full text
Upregulated expression of SSTR1 is involved in neuronal apoptosis and is coupled to the reduction of bcl-2 following intracerebral hemorrhage in adult rats. / 10.2014 / PubMed / Full text

ST6GAL1

Glycobiology of Aging. / 2018 / PubMed / Full text
Identification of novel plasma glycosylation-associated markers of aging. / 16.02.2016 / PubMed / Full text

STAT5A

Novel molecular mechanisms for the adaptogenic effects of herbal extracts on isolated brain cells using systems biology. / 15.11.2018 / PubMed / Full text
SOCS1 regulates senescence and ferroptosis by modulating the expression of p53 target genes. / 28.10.2017 / PubMed / Full text

STK3

Dual functions for OVAAL in initiation of RAF/MEK/ERK prosurvival signals and evasion of p27-mediated cellular senescence. / 11.12.2018 / PubMed / Full text
Organ-specific alteration in caspase expression and STK3 proteolysis during the aging process. / 11.2016 / PubMed / Full text

STN1

CTC1-STN1 coordinates G- and C-strand synthesis to regulate telomere length. / 08.2018 / PubMed / Full text
A gain-of-function senescence bypass screen identifies the homeobox transcription factor DLX2 as a regulator of ATM-p53 signaling. / 01.02.2016 / PubMed / Full text

SURF1

Lifelong reduction in complex IV induces tissue-specific metabolic effects but does not reduce lifespan or healthspan in mice. / 08.2018 / PubMed / Full text
Complex IV-deficient Surf1(-/-) mice initiate mitochondrial stress responses. / 01.09.2014 / PubMed / Full text

SUZ12

Epigallocatechin-3-gallate and BIX-01294 have different impact on epigenetics and senescence modulation in acute and chronic myeloid leukemia cells. / 05.11.2018 / PubMed / Full text
Polycomb repressive complex 2 epigenomic signature defines age-associated hypermethylation and gene expression changes. / 2015 / PubMed / Full text

SV2A

Assessing Synaptic Density in Alzheimer Disease With Synaptic Vesicle Glycoprotein 2A Positron Emission Tomographic Imaging. / 01.10.2018 / PubMed / Full text
Mutant Huntingtin Causes a Selective Decrease in the Expression of Synaptic Vesicle Protein 2C. / 10.2018 / PubMed / Full text

SYNJ1

Excess Synaptojanin 1 Contributes to Place Cell Dysfunction and Memory Deficits in the Aging Hippocampus in Three Types of Alzheimer's Disease. / 05.06.2018 / PubMed / Full text
Coordinated Expression of Phosphoinositide Metabolic Genes during Development and Aging of Human Dorsolateral Prefrontal Cortex. / 2015 / PubMed / Full text

TAL1

Transcriptomic analysis of purified human cortical microglia reveals age-associated changes. / 08.2017 / PubMed / Full text
Microglia recapitulate a hematopoietic master regulator network in the aging human frontal cortex. / 08.2015 / PubMed / Full text

TAP1

Age-associated methylation change of TAP1 promoter in piglet. / 15.11.2015 / PubMed / Full text
Lifespan of mice and primates correlates with immunoproteasome expression. / 05.2015 / PubMed / Full text

TARDBP

Selective Spatiotemporal Vulnerability of Central Nervous System Neurons to Pathologic TAR DNA-Binding Protein 43 in Aged Transgenic Mice. / 06.2018 / PubMed / Full text
Frontotemporal dementia: insights into the biological underpinnings of disease through gene co-expression network analysis. / 24.02.2016 / PubMed / Full text

TAS2R16

Taste receptor polymorphisms and longevity: a systematic review and meta-analysis. / 10.11.2020 / PubMed / Full text
Taste receptors, innate immunity and longevity: the case of TAS2R16 gene. / 2019 / PubMed / Full text

TBC1D5

TBC1D5-Catalyzed Cycling of Rab7 Is Required for Retromer-Mediated Human Papillomavirus Trafficking during Virus Entry. / 09.06.2020 / PubMed / Full text
Retromer and TBC1D5 maintain late endosomal RAB7 domains to enable amino acid-induced mTORC1 signaling. / 02.09.2019 / PubMed / Full text

TBK1

Parkin overexpression alleviates cardiac aging through facilitating K63-polyubiquitination of TBK1 to facilitate mitophagy. / 01.01.2021 / PubMed / Full text
TBK1 Suppresses RIPK1-Driven Apoptosis and Inflammation during Development and in Aging. / 06.09.2018 / PubMed / Full text

TCF7

Osteoprotection Through the Deletion of the Transcription Factor Rorβ in Mice. / 04.2018 / PubMed / Full text
Age-related profiling of DNA methylation in CD8 T cells reveals changes in immune response and transcriptional regulator genes. / 19.08.2015 / PubMed / Full text

TDG

lncRNA H19 contributes to oxidative damage repair in the early age-related cataract by regulating miR-29a/TDG axis. / 09.2019 / PubMed / Full text
Survival Rates of Out-Migrating Yearling Chinook Salmon in the Lower Columbia River and Plume after Exposure to Gas-Supersaturated Water. / 12.2016 / PubMed / Full text

TDP1

UCHL3 Regulates Topoisomerase-Induced Chromosomal Break Repair by Controlling TDP1 Proteostasis. / 12.06.2018 / PubMed / Full text
Neuroprotection and repair of 3'-blocking DNA ends by glaikit (gkt) encoding Drosophila tyrosyl-DNA phosphodiesterase 1 (TDP1). / 04.11.2014 / PubMed / Full text

TEAD1

[Role of PLAT, PKHD1L1, STK38L and TEAD1 genes Alu-polymorphism for longevity]. / 2016 / PubMed
Acetylation of VGLL4 Regulates Hippo-YAP Signaling and Postnatal Cardiac Growth. / 21.11.2016 / PubMed / Full text

TERF1

Telomere protein RAP1 levels are affected by cellular aging and oxidative stress. / 08.2016 / PubMed / Full text
Population-specific association of genes for telomere-associated proteins with longevity in an Italian population. / 06.2015 / PubMed / Full text

TIMELESS

Loss of circadian protein TIMELESS accelerates the progression of cellular senescence. / 18.09.2018 / PubMed / Full text
Clock gene expression and locomotor activity predict death in the last days of life in Drosophila melanogaster. / 09.08.2018 / PubMed / Full text

TIMP2

The effects of aging, diabetes mellitus, and antiplatelet drugs on growth factors and anti-aging proteins in platelet-rich plasma. / 2019 / PubMed / Full text
Human umbilical cord plasma proteins revitalize hippocampal function in aged mice. / 27.04.2017 / PubMed / Full text

TLR3

Repetitive TLR3 activation in the lung induces skeletal muscle adaptations and cachexia. / 06.2018 / PubMed / Full text
Age-related changes and distribution of T cell markers (CD3 and CD4) and toll-like receptors(TLR2, TLR3,TLR4 and TLR7) in the duck lymphoid organs. / 07.2017 / PubMed / Full text

TMEM119

Dexamethasone Induces a Specific Form of Ramified Dysfunctional Microglia. / 02.2019 / PubMed / Full text
Loss of 'homeostatic' microglia and patterns of their activation in active multiple sclerosis. / 01.07.2017 / PubMed / Full text

TMPRSS2

Susceptibility to COVID-19 in populations with health disparities: Posited involvement of mitochondrial disorder, socioeconomic stress, and pollutants. / 09.09.2020 / PubMed / Full text
Expression of the SARS-CoV-2 Entry Proteins, ACE2 and TMPRSS2, in Cells of the Olfactory Epithelium: Identification of Cell Types and Trends with Age. / 03.06.2020 / PubMed / Full text

TOMM20

Effect of aging on mitochondria and metabolism of bovine granulosa cells. / 13.09.2020 / PubMed / Full text
PARK2-mediated mitophagy is involved in regulation of HBEC senescence in COPD pathogenesis. / 2015 / PubMed / Full text

TOP1

UCHL3 Regulates Topoisomerase-Induced Chromosomal Break Repair by Controlling TDP1 Proteostasis. / 12.06.2018 / PubMed / Full text
mir-24 activity propagates stress-induced senescence by down regulating DNA topoisomerase 1. / 03.2016 / PubMed / Full text

TOX

Temporal Cognitive Decline Associated With Exposure to Infectious Agents in a Population-based, Aging Cohort. / 07-09.2016 / PubMed / Full text
THE EFFECTS OF XANTHOTOXIN ON THE BIOLOGY AND BIOCHEMISTRY OF Galleria mellonella L. (LEPIDOPTERA: PYRALIDAE). / 08.2015 / PubMed / Full text

TPH2

Ageing and gastrointestinal sensory function: altered colonic mechanosensory and chemosensory function in the aged mouse. / 15.08.2016 / PubMed / Full text
Effect of tryptophan hydroxylase-2 gene polymorphism G-703 T on personality in a population representative sample. / 03.03.2015 / PubMed / Full text

TRAF2

The Misshapen subfamily of Ste20 kinases regulate proliferation in the aging mammalian intestinal epithelium. / 12.2019 / PubMed / Full text
Ubiquitination of inositol-requiring enzyme 1 (IRE1) by the E3 ligase CHIP mediates the IRE1/TRAF2/JNK pathway. / 31.10.2014 / PubMed / Full text

TREX1

Mechanistic link between DNA damage sensing, repairing and signaling factors and immune signaling. / 2019 / PubMed / Full text
Mendelian adult-onset leukodystrophy genes in Alzheimer's disease: critical influence of CSF1R and NOTCH3. / 06.2018 / PubMed / Full text

TRH

Neonatal exposure to bisphenol A alters the hypothalamic-pituitary-thyroid axis in female rats. / 15.03.2018 / PubMed / Full text
Effect of dietary carbohydrates and time of year on ACTH and cortisol concentrations in adult and aged horses. / 04.2018 / PubMed / Full text

TRIM28

Depleting Trim28 in adult mice is well tolerated and reduces levels of α-synuclein and tau. / 04.06.2018 / PubMed / Full text
Polyphenic trait promotes liver cancer in a model of epigenetic instability in mice. / 07.2017 / PubMed / Full text

TRIP13

BubR1 allelic effects drive phenotypic heterogeneity in mosaic-variegated aneuploidy progeria syndrome. / 02.01.2020 / PubMed / Full text
PCH-2 regulates Caenorhabditis elegans lifespan. / 01.2015 / PubMed / Full text

TRPC3

Age-dependent alpha-synuclein accumulation is correlated with elevation of mitochondrial TRPC3 in the brains of monkeys and mice. / 04.2017 / PubMed / Full text
TRPC3 channels critically regulate hippocampal excitability and contextual fear memory. / 15.03.2015 / PubMed / Full text

TRPC5

TRPC5 channel modulates endothelial cells senescence. / 05.05.2017 / PubMed / Full text
Benzimidazole derivative M084 extends the lifespan of Caenorhabditis elegans in a DAF-16/FOXO-dependent way. / 02.2017 / PubMed / Full text

TRPC6

Redox and mTOR-dependent regulation of plasma lamellar calcium influx controls the senescence-associated secretory phenotype. / 11.2020 / PubMed / Full text
TRPC6 in simulated microgravity of intervertebral disc cells. / 10.2018 / PubMed / Full text

TRPM6

Role of kinase-coupled TRP channels in mineral homeostasis. / 04.2018 / PubMed / Full text
Epithelial magnesium transport by TRPM6 is essential for prenatal development and adult survival. / 19.12.2016 / PubMed / Full text

TRPM7

mRNA expression of transient receptor potential melastatin (TRPM) channels 2 and 7 in perinatal brain development. / 10.2018 / PubMed / Full text
Role of kinase-coupled TRP channels in mineral homeostasis. / 04.2018 / PubMed / Full text

TRPV6

Changes in expression of klotho affect physiological processes, diseases, and cancer. / 01.2018 / PubMed / Full text
Molecular aspects of intestinal calcium absorption. / 21.06.2015 / PubMed / Full text

TSHB

Adipose TSHB in Humans and Serum TSH in Hypothyroid Rats Inform About Cellular Senescence. / 2018 / PubMed / Full text
Loss of basal and TRH-stimulated Tshb expression in dispersed pituitary cells. / 01.2015 / PubMed / Full text

TSLP

Cloning and expression of recombinant equine interleukin-3 and its effect on sulfidoleukotriene and cytokine production by equine peripheral blood leukocytes. / 15.02.2015 / PubMed / Full text
Accumulation of prelamin A compromises NF-κB-regulated B-lymphopoiesis in a progeria mouse model. / 2013 / PubMed / Full text

TTN

LncRNA TTN-AS1 regulates osteosarcoma cell apoptosis and drug resistance via the miR-134-5p/MBTD1 axis. / 10.10.2019 / PubMed / Full text
Novel molecular mechanisms for the adaptogenic effects of herbal extracts on isolated brain cells using systems biology. / 15.11.2018 / PubMed / Full text

TYR

Phosphorylation of MITF by AKT affects its downstream targets and causes TP53-dependent cell senescence. / 11.2016 / PubMed / Full text
Gene expression profiling to investigate tyrosol-induced lifespan extension in Caenorhabditis elegans. / 03.2016 / PubMed / Full text

U2AF1

Isobaric tags for relative and absolute quantitation (iTRAQ)-based proteomic analysis of mRNA splicing relevant proteins in aging HSPCs. / 05.03.2020 / PubMed / Full text
Insight into the molecular pathophysiology of myelodysplastic syndromes: targets for novel therapy. / 10.2016 / PubMed / Full text

UBB

Different Expression Levels of Human Mutant Ubiquitin B (UBB ) Can Modify Chronological Lifespan or Stress Resistance of [i]Saccharomyces cerevisiae[/i]. / 2018 / PubMed / Full text
Modeling non-hereditary mechanisms of Alzheimer disease during apoptosis in yeast. / 20.03.2015 / PubMed / Full text

UGT1A1

Expression of UDP-Glucuronosyltransferase 1 (UGT1) and Glucuronidation Activity toward Endogenous Substances in Humanized UGT1 Mouse Brain. / 07.2015 / PubMed / Full text
Age-related changes in mRNA levels of hepatic transporters, cytochrome P450 and UDP-glucuronosyltransferase in female rats. / 06.2015 / PubMed / Full text

ULBP2

NKG2D ligands mediate immunosurveillance of senescent cells. / 02.2016 / PubMed / Full text
Type 1 interferons contribute to the clearance of senescent cell. / 2015 / PubMed / Full text

UMOD

The relationships between markers of tubular injury and intrarenal haemodynamic function in adults with and without type 1 diabetes: Results from the Canadian Study of Longevity in Type 1 Diabetes. / 03.2019 / PubMed / Full text
A roadmap for the genetic analysis of renal aging. / 10.2015 / PubMed / Full text

UNG

UNG-1 and APN-1 are the major enzymes to efficiently repair 5-hydroxymethyluracil DNA lesions in C. elegans. / 01.05.2018 / PubMed / Full text
Caenorhabditis elegans EXO-3 contributes to longevity and reproduction: differential roles in somatic cells and germ cells. / 02.2015 / PubMed / Full text

UQCRC2

Elucidation of the mechanism of changes in the antioxidant function with the aging in the liver of the senescence-accelerated mouse P10 (SAMP10). / 06.2018 / PubMed / Full text
Resveratrol Protects SAMP8 Brain Under Metabolic Stress: Focus on Mitochondrial Function and Wnt Pathway. / 04.2017 / PubMed / Full text

VASH1

Double-Face of Vasohibin-1 for the Maintenance of Vascular Homeostasis and Healthy Longevity. / 01.06.2018 / PubMed / Full text
Age-associated downregulation of vasohibin-1 in vascular endothelial cells. / 10.2016 / PubMed / Full text

VASP

Reversal of Aging-Induced Increases in Aortic Stiffness by Targeting Cytoskeletal Protein-Protein Interfaces. / 18.07.2018 / PubMed / Full text
In vitro anti-platelet potency of ticagrelor in blood samples from infants and children. / 09.2015 / PubMed / Full text

VCAN

Deletion of miR-126a Promotes Hepatic Aging and Inflammation in a Mouse Model of Cholestasis. / 07.06.2019 / PubMed / Full text
Exosomes from hyperglycemia-stimulated vascular endothelial cells contain versican that regulate calcification/senescence in vascular smooth muscle cells. / 2019 / PubMed / Full text

VEGFA

APOE ε4-specific associations of VEGF gene family expression with cognitive aging and Alzheimer's disease. / 03.2020 / PubMed / Full text
Regulation of Vegf signaling by natural and synthetic ligands. / 10.11.2016 / PubMed / Full text

VGF

Voluntary Running Triggers VGF-Mediated Oligodendrogenesis to Prolong the Lifespan of Snf2h-Null Ataxic Mice. / 11.10.2016 / PubMed / Full text
Age-related obesity and type 2 diabetes dysregulate neuronal associated genes and proteins in humans. / 06.10.2015 / PubMed / Full text

VGLL3

The vgll3 Locus Controls Age at Maturity in Wild and Domesticated Atlantic Salmon (Salmo salar L.) Males. / 11.2015 / PubMed / Full text
Sex-dependent dominance at a single locus maintains variation in age at maturity in salmon. / 17.12.2015 / PubMed / Full text

VGLL4

The lncRNA MEG3/miR-16-5p/VGLL4 regulatory axis is involved in etoposide-induced senescence of tumor cells. / 03.11.2020 / PubMed / Full text
Acetylation of VGLL4 Regulates Hippo-YAP Signaling and Postnatal Cardiac Growth. / 21.11.2016 / PubMed / Full text

VIT

Autophagy-mediated longevity is modulated by lipoprotein biogenesis. / 2016 / PubMed / Full text
ASSOCIATION OF PREVASCULAR VITREOUS FISSURES AND CISTERNS WITH VITREOUS DEGENERATION AS ASSESSED BY SWEPT SOURCE OPTICAL COHERENCE TOMOGRAPHY. / 09.2015 / PubMed / Full text

VPS29

Combined Proteomic and Metabolomic Profiling of the [i]Arabidopsis thaliana vps29[/i] Mutant Reveals Pleiotropic Functions of the Retromer in Seed Development. / 16.01.2019 / PubMed / Full text
The retromer complex system in a transgenic mouse model of AD: influence of age. / 04.2017 / PubMed / Full text

VPS35

Combined Proteomic and Metabolomic Profiling of the [i]Arabidopsis thaliana vps29[/i] Mutant Reveals Pleiotropic Functions of the Retromer in Seed Development. / 16.01.2019 / PubMed / Full text
Vps35 haploinsufficiency results in degenerative-like deficit in mouse retinal ganglion neurons and impairment of optic nerve injury-induced gliosis. / 11.02.2014 / PubMed / Full text

WFIKKN1

Relationship of Circulating Growth and Differentiation Factors 8 and 11 and Their Antagonists as Measured Using Liquid Chromatography-Tandem Mass Spectrometry With Age and Skeletal Muscle Strength in Healthy Adults. / 01.01.2019 / PubMed / Full text
A targeted proteomic assay for the measurement of plasma proteoforms related to human aging phenotypes. / 08.2017 / PubMed / Full text

WFIKKN2

Relationship of Circulating Growth and Differentiation Factors 8 and 11 and Their Antagonists as Measured Using Liquid Chromatography-Tandem Mass Spectrometry With Age and Skeletal Muscle Strength in Healthy Adults. / 01.01.2019 / PubMed / Full text
A targeted proteomic assay for the measurement of plasma proteoforms related to human aging phenotypes. / 08.2017 / PubMed / Full text

WFS1

Knockdown of wfs1, a fly homolog of Wolfram syndrome 1, in the nervous system increases susceptibility to age- and stress-induced neuronal dysfunction and degeneration in Drosophila. / 01.2018 / PubMed / Full text
A nonsynonymous mutation in the WFS1 gene in a Finnish family with age-related hearing impairment. / 11.2017 / PubMed / Full text

WIPI2

Neuronal autophagy declines substantially with age and is rescued by overexpression of WIPI2. / 02.2020 / PubMed / Full text
The ATG5-binding and coiled coil domains of ATG16L1 maintain autophagy and tissue homeostasis in mice independently of the WD domain required for LC3-associated phagocytosis. / 04.2019 / PubMed / Full text

WNT16

Inducible [i]Wnt16[/i] inactivation: WNT16 regulates cortical bone thickness in adult mice. / 05.2018 / PubMed / Full text
Osteoblast-derived WNT16 represses osteoclastogenesis and prevents cortical bone fragility fractures. / 11.2014 / PubMed / Full text

WNT5A

WNT5A supports viability of senescent human dental follicle cells. / 05.2019 / PubMed / Full text
The Ubiquitin-like with PHD and Ring Finger Domains 1 (UHRF1)/DNA Methyltransferase 1 (DNMT1) Axis Is a Primary Regulator of Cell Senescence. / 03.03.2017 / PubMed / Full text

WWP1

The ubiquitin ligase WWP1 contributes to shifts in matrix proteolytic profiles and a myocardial aging phenotype with diastolic heart. / 01.10.2020 / PubMed / Full text
Overexpression of miR-584-5p inhibits proliferation and induces apoptosis by targeting WW domain-containing E3 ubiquitin protein ligase 1 in gastric cancer. / 21.04.2017 / PubMed / Full text

XDH

Enhancing xanthine dehydrogenase activity is an effective way to delay leaf senescence and increase rice yield. / 11.03.2020 / PubMed / Full text
Pleurotus ostreatus, an edible mushroom, enhances glucose 6-phosphate dehydrogenase, ascorbate peroxidase and reduces xanthine dehydrogenase in major organs of aged rats. / 05.2014 / PubMed / Full text

XRCC6

Programmed Cell Death Genes Are Linked to Elevated Creatine Kinase Levels in Unhealthy Male Nonagenarians. / 2016 / PubMed / Full text
The impact of statins on biological characteristics of stem cells provides a novel explanation for their pleiotropic beneficial and adverse clinical effects. / 15.10.2015 / PubMed / Full text

ZBTB16

miR-19b-3p induces cell proliferation and reduces heterochromatin-mediated senescence through PLZF in goat male germline stem cells. / 06.2018 / PubMed / Full text
Determination phase at transition of gonocytes to spermatogonial stem cells improves establishment efficiency of spermatogonial stem cells in domestic cats. / 2015 / PubMed / Full text

ZC3H12A

Keratinocyte-specific ablation of Mcpip1 impairs skin integrity and promotes local and systemic inflammation. / 12.2019 / PubMed / Full text
Prediction and characterization of human ageing-related proteins by using machine learning. / 06.03.2018 / PubMed / Full text

ZEB2

miR-200b regulates cellular senescence and inflammatory responses by targeting ZEB2 in pulmonary emphysema. / 12.2020 / PubMed / Full text
MicroRNA-145 induces the senescence of activated hepatic stellate cells through the activation of p53 pathway by ZEB2. / 05.2019 / PubMed / Full text

ZNF521

Reduced subcutaneous adipogenesis in human hypertrophic obesity is linked to senescent precursor cells. / 21.06.2019 / PubMed / Full text
Zinc finger factor 521 enhances adipogenic differentiation of mouse multipotent cells and human bone marrow mesenchymal stem cells. / 20.06.2015 / PubMed / Full text

ZSCAN10

RNA Exosome Complex-Mediated Control of Redox Status in Pluripotent Stem Cells. / 10.10.2017 / PubMed / Full text
ZSCAN10 expression corrects the genomic instability of iPSCs from aged donors. / 09.2017 / PubMed / Full text

ABCC1

Dual pathways mediate β-amyloid stimulated glutathione release from astrocytes. / 12.2015 / PubMed / Full text

ABCC3

Proteomic Analysis of the Developmental Trajectory of Human Hepatic Membrane Transporter Proteins in the First Three Months of Life. / 07.2016 / PubMed / Full text

ABCE1

Widespread Accumulation of Ribosome-Associated Isolated 3' UTRs in Neuronal Cell Populations of the Aging Brain. / 27.11.2018 / PubMed / Full text

ABCG1

Disrupted cholesterol metabolism promotes age-related photoreceptor neurodegeneration. / 08.2018 / PubMed / Full text

ABCG5

2, 3, 4', 5-tetrahydroxystilbene-2-0-β-d Glycoside Attenuates Age- and Diet-Associated Non-Alcoholic Steatohepatitis and Atherosclerosis in LDL Receptor Knockout Mice and Its Possible Mechanisms. / 01.04.2019 / PubMed / Full text

ABHD12

Elevated Levels of Arachidonic Acid-Derived Lipids Including Prostaglandins and Endocannabinoids Are Present Throughout ABHD12 Knockout Brains: Novel Insights Into the Neurodegenerative Phenotype. / 2019 / PubMed / Full text

ABI3BP

Long noncoding RNA MALAT1 potentiates growth and inhibits senescence by antagonizing ABI3BP in gallbladder cancer cells. / 07.06.2019 / PubMed / Full text

ABL1

European LeukemiaNet 2020 recommendations for treating chronic myeloid leukemia. / 04.2020 / PubMed / Full text

ABLIM3

Dentate granule cell recruitment of feedforward inhibition governs engram maintenance and remote memory generalization. / 05.2018 / PubMed / Full text

ACAA2

p46Shc Inhibits Thiolase and Lipid Oxidation in Mitochondria. / 10.06.2016 / PubMed / Full text

ACAD9

Identification of a novel mitochondrial complex I assembly factor ACDH-12 in Caenorhabditis elegans. / 05.2019 / PubMed / Full text

ACADM

High fat diet aggravates atrial and ventricular remodeling of hypertensive heart disease in aging rats. / 07.2018 / PubMed / Full text

ACAT2

Serum starvation of ARPE-19 changes the cellular distribution of cholesterol and Fibulin3 in patterns reminiscent of age-related macular degeneration. / 15.12.2017 / PubMed / Full text

ACKR2

Atypical chemokine receptor ACKR2 mediates chemokine scavenging by primary human trophoblasts and can regulate fetal growth, placental structure, and neonatal mortality in mice. / 15.11.2014 / PubMed / Full text

ACMSD

De novo NAD synthesis enhances mitochondrial function and improves health. / 11.2018 / PubMed / Full text

ACP2

Association of levels of fasting glucose and insulin with rare variants at the chromosome 11p11.2-MADD locus: Cohorts for Heart and Aging Research in Genomic Epidemiology (CHARGE) Consortium Targeted Sequencing Study. / 06.2014 / PubMed / Full text

ACSL5

Ageing sensitized by iPLA β deficiency induces liver fibrosis and intestinal atrophy involving suppression of homeostatic genes and alteration of intestinal lipids and bile acids. / 12.2017 / PubMed / Full text

ACTA2

Tissue Taurine Depletion Induces Profibrotic Pattern of Gene Expression and Causes Aging-Related Cardiac Fibrosis in Heart in Mice. / 2018 / PubMed / Full text

ACTL7B

Genome-Wide Association Analysis of the Sense of Smell in U.S. Older Adults: Identification of Novel Risk Loci in African-Americans and European-Americans. / 12.2017 / PubMed / Full text

ACTR3B

Gene Expression Analysis Reveals Novel Gene Signatures Between Young and Old Adults in Human Prefrontal Cortex. / 2018 / PubMed / Full text

ADA2

Manganese(II) Chloride Alters Nucleotide and Nucleoside Catabolism in Zebrafish (Danio rerio) Adult Brain. / 05.2018 / PubMed / Full text

ADAM19

ADAM19 and HTR4 variants and pulmonary function: Cohorts for Heart and Aging Research in Genomic Epidemiology (CHARGE) Consortium Targeted Sequencing Study. / 06.2014 / PubMed / Full text

ADAMTS1

Increased ADAMTS1 mediates SPARC-dependent collagen deposition in the aging myocardium. / 01.06.2016 / PubMed / Full text

ADAMTS10

Influence of Age on Ocular Biomechanical Properties in a Canine Glaucoma Model with ADAMTS10 Mutation. / 2016 / PubMed / Full text

ADAMTS3

Explorative results from multistep screening for potential genetic risk loci of Alzheimer's disease in the longitudinal VITA study cohort. / 01.2018 / PubMed / Full text

ADAMTS5

Endoplasmic reticulum stress participates in the progress of senescence and apoptosis of osteoarthritis chondrocytes. / 16.09.2017 / PubMed / Full text

ADAR

Enoxacin extends lifespan of C. elegans by inhibiting miR-34-5p and promoting mitohormesis. / 09.2018 / PubMed / Full text

ADCK1

Functional analysis of Aarf domain-containing kinase 1 in Drosophila melanogaster. / 09.2019 / PubMed / Full text

ADD2

SerThr-PhosphoProteome of Brain from Aged PINK1-KO A53T-SNCA Mice Reveals pT1928-MAP1B and pS3781-ANK2 Deficits, as Hub between Autophagy and Synapse Changes. / 04.07.2019 / PubMed / Full text

ADK

Deletion of pancreatic β-cell adenosine kinase improves glucose homeostasis in young mice and ameliorates streptozotocin-induced hyperglycaemia. / 07.2019 / PubMed / Full text

ADNP2

ADNP differentially interact with genes/proteins in correlation with aging: a novel marker for muscle aging. / 06.2019 / PubMed / Full text

ADORA2B

Adenosine A2B receptor: A pathogenic factor and a therapeutic target for sensorineural hearing loss. / 12.2020 / PubMed / Full text

ADRA2A

α2A-Adrenergic Receptor Inhibits the Progression of Cervical Cancer Through Blocking PI3K/AKT/mTOR Pathway. / 2020 / PubMed / Full text

ADRM1

Androgen receptor polyglutamine expansion drives age-dependent quality control defects and muscle dysfunction. / 01.08.2018 / PubMed / Full text

AGAP2

Exosomes derived from microRNA-199a-overexpressing mesenchymal stem cells inhibit glioma progression by down-regulating AGAP2. / 05.08.2019 / PubMed / Full text

AGL

Exercise-associated DNA methylation change in skeletal muscle and the importance of imprinted genes: a bioinformatics meta-analysis. / 12.2015 / PubMed / Full text

AGO1

A transcriptome-wide study on the microRNA- and the Argonaute 1-enriched small RNA-mediated regulatory networks involved in plant leaf senescence. / 03.2016 / PubMed / Full text

AGRP

Influence of Aging and Gender Differences on Feeding Behavior and Ghrelin-Related Factors during Social Isolation in Mice. / 2015 / PubMed / Full text

AHNAK

A novel atlas of gene expression in human skeletal muscle reveals molecular changes associated with aging. / 2015 / PubMed / Full text

AHSP

Relationship between Sensory Perception and Frailty in a Community-Dwelling Elderly Population. / 2017 / PubMed / Full text

AIF1

Sirtuin 1-Chromatin-Binding Dynamics Points to a Common Mechanism Regulating Inflammatory Targets in SIV Infection and in the Aging Brain. / 06.2018 / PubMed / Full text

AK1

The dominant negative ARM domain uncovers multiple functions of PUB13 in Arabidopsis immunity, flowering, and senescence. / 06.2015 / PubMed / Full text

AKAP11

Genetic Burden Analyses of Phenotypes Relevant to Aging in the Berlin Aging Study II (BASE-II). / 2016 / PubMed / Full text

AKAP12

A-Kinase Anchor Protein 12 Is Required for Oligodendrocyte Differentiation in Adult White Matter. / 05.2018 / PubMed / Full text

AKAP17A

The transcript expression levels of HNRNPM, HNRNPA0 and AKAP17A splicing factors may be predictively associated with ageing phenotypes in human peripheral blood. / 10.2019 / PubMed / Full text

AKIP1

Expression of potato RNA-binding proteins StUBA2a/b and StUBA2c induces hypersensitive-like cell death and early leaf senescence in Arabidopsis. / 07.2015 / PubMed / Full text

AKR1B1

Bioinformatics analysis of proteomics profiles in senescent human primary proximal tubule epithelial cells. / 01.04.2016 / PubMed / Full text

AKR1C2

Identification of a gene signature of a pre-transformation process by senescence evasion in normal human epidermal keratinocytes. / 14.06.2014 / PubMed / Full text

AKR1C3

Identification of a gene signature of a pre-transformation process by senescence evasion in normal human epidermal keratinocytes. / 14.06.2014 / PubMed / Full text

AKR7A3

The aged testis. A good model to find proteins involved in age-related changes of testis by proteomic analysis. / 01-02.2014 / PubMed

AKT2

Therapeutic and preventive effects of exercise on cardiometabolic parameters in aging and obese rats. / 02.2019 / PubMed / Full text

ALAD

Lead-Related Genetic Loci, Cumulative Lead Exposure and Incident Coronary Heart Disease: The Normative Aging Study. / 2016 / PubMed / Full text

ALAS1

Heterozygous disruption of ALAS1 in mice causes an accelerated age-dependent reduction in free heme, but not total heme, in skeletal muscle and liver. / 08.12.2020 / PubMed / Full text

ALAS2

Gene transcripts associated with muscle strength: a CHARGE meta-analysis of 7,781 persons. / 01.2016 / PubMed / Full text

ALDH1A1

Aldehyde Dehydrogenase 1 making molecular inroads into the differential vulnerability of nigrostriatal dopaminergic neuron subtypes in Parkinson's disease. / 2014 / PubMed / Full text

ALDH1L1

Review: Astrocytes in Alzheimer's disease and other age-associated dementias: a supporting player with a central role. / 06.2017 / PubMed / Full text

ALDH3A1

Hallmarks of the cancer cell of origin: Comparisons with "energetic" cancer stem cells (e-CSCs). / 13.02.2019 / PubMed / Full text

ALDOA

An Adult Drosophila Glioma Model for Studying Pathometabolic Pathways of Gliomagenesis. / 06.2019 / PubMed / Full text

ALKBH1

ALKB-8, a 2-Oxoglutarate-Dependent Dioxygenase and S-Adenosine Methionine-Dependent Methyltransferase Modulates Metabolic Events Linked to Lysosome-Related Organelles and Aging in C. elegans. / 2018 / PubMed

ALKBH2

ALKB-8, a 2-Oxoglutarate-Dependent Dioxygenase and S-Adenosine Methionine-Dependent Methyltransferase Modulates Metabolic Events Linked to Lysosome-Related Organelles and Aging in C. elegans. / 2018 / PubMed

ALOX12

Arachidonate 12-lipoxygenase and 12-hydroxyeicosatetraenoic acid contribute to stromal aging-induced progression of pancreatic cancer. / 15.05.2020 / PubMed / Full text

ALOX5

Functional Characterization of Knock-In Mice Expressing a 12/15-Lipoxygenating Alox5 Mutant Instead of the 5-Lipoxygenating Wild-Type Enzyme. / 01.01.2020 / PubMed / Full text

ALS2

Age-dependent deterioration of locomotion in Drosophila melanogaster deficient in the homologue of amyotrophic lateral sclerosis 2. / 06.2014 / PubMed / Full text

AMBRA1

MiR-23a-depressed autophagy is a participant in PUVA- and UVB-induced premature senescence. / 21.06.2016 / PubMed / Full text

AMFR

Mice heterozygous for the Cdh23/Ahl1 mutation show age-related deficits in auditory temporal processing. / 09.2019 / PubMed / Full text

AMHR2

Long-lived rodents reveal signatures of positive selection in genes associated with lifespan. / 03.2018 / PubMed / Full text

ANGPT1

Altered microRNA expression in bovine skeletal muscle with age. / 06.2015 / PubMed / Full text

ANGPT2

Systemic analysis of gene expression profiles in porcine granulosa cells during aging. / 14.11.2017 / PubMed / Full text

ANGPTL4

Involvement of ERK1/2 activation in the gene expression of senescence-associated secretory factors in human hepatic stellate cells. / 05.2019 / PubMed / Full text

ANGPTL8

Angiopoietin-like protein 8 (ANGPTL8)/betatrophin overexpression does not increase beta cell proliferation in mice. / 07.2015 / PubMed / Full text

ANK2

SerThr-PhosphoProteome of Brain from Aged PINK1-KO A53T-SNCA Mice Reveals pT1928-MAP1B and pS3781-ANK2 Deficits, as Hub between Autophagy and Synapse Changes. / 04.07.2019 / PubMed / Full text

ANKS1B

Explorative results from multistep screening for potential genetic risk loci of Alzheimer's disease in the longitudinal VITA study cohort. / 01.2018 / PubMed / Full text

ANPEP

Aminopeptidase N expression in the endometrium could affect endometrial receptivity. / 25.06.2019 / PubMed / Full text

ANXA1

Assessment of Human Skin Gene Expression by Different Blends of Plant Extracts with Implications to Periorbital Skin Aging. / 26.10.2018 / PubMed / Full text

AOX1

N1-Methylnicotinamide: An Anti-Ovarian Aging Hormetin? / 09.2020 / PubMed / Full text

APAF1

Sperm-associated antigen 9 (SPAG9) promotes the survival and tumor growth of triple-negative breast cancer cells. / 10.2016 / PubMed / Full text

APBB2

GSK3β Interactions with Amyloid Genes: An Autopsy Verification and Extension. / 10.2015 / PubMed / Full text

APLNR

Endothelial APLNR regulates tissue fatty acid uptake and is essential for apelin's glucose-lowering effects. / 13.09.2017 / PubMed / Full text

APOA4

No Association between Variation in Longevity Candidate Genes and Aging-related Phenotypes in Oldest-old Danes. / 06.2016 / PubMed / Full text

APOBEC1

Loss of APOBEC1 RNA-editing function in microglia exacerbates age-related CNS pathophysiology. / 12.12.2017 / PubMed / Full text

APOC1

Genetics of Human Longevity From Incomplete Data: New Findings From the Long Life Family Study. / 08.10.2018 / PubMed / Full text

APOC2

Apoc2 loss-of-function zebrafish mutant as a genetic model of hyperlipidemia. / 01.08.2015 / PubMed / Full text

APOD

Apolipoprotein D takes center stage in the stress response of the aging and degenerative brain. / 07.2014 / PubMed / Full text

APOH

Genome-wide significant results identified for plasma apolipoprotein H levels in middle-aged and older adults. / 31.03.2016 / PubMed / Full text

APPL1

Insulin and adipokine signaling and their cross-regulation in postmortem human brain. / 12.2019 / PubMed / Full text

AQP2

A bell-shaped pattern of urinary aquaporin-2-bearing extracellular vesicle release in an experimental model of nephronophthisis. / 05.2019 / PubMed / Full text

AQP9

Seasonal and Ageing-Depending Changes of Aquaporins 1 and 9 Expression in the Genital Tract of Buffalo Bulls (Bubalus bubalis). / 08.2016 / PubMed / Full text

AQR

Synergism between soluble guanylate cyclase signaling and neuropeptides extends lifespan in the nematode Caenorhabditis elegans. / 04.2017 / PubMed / Full text

ARG1

Extended Multiplexing of Tandem Mass Tags (TMT) Labeling Reveals Age and High Fat Diet Specific Proteome Changes in Mouse Epididymal Adipose Tissue. / 05.2017 / PubMed / Full text

ARG2

Arginase-2, a miR-1299 target, enhances pigmentation in melasma by reducing melanosome degradation via senescence-induced autophagy inhibition. / 01.2017 / PubMed / Full text

ARHGAP1

Targeted sequencing of genome wide significant loci associated with bone mineral density (BMD) reveals significant novel and rare variants: the Cohorts for Heart and Aging Research in Genomic Epidemiology (CHARGE) targeted sequencing study. / 01.12.2016 / PubMed / Full text

ARID5A

Differentially regulated gene expression in quiescence versus senescence and identification of ARID5A as a quiescence associated marker. / 05.2018 / PubMed / Full text

ARIH2

A novel feed-forward loop between ARIH2 E3-ligase and PABPN1 regulates aging-associated muscle degeneration. / 04.2014 / PubMed / Full text

ARL13B

ARL13B, a Joubert Syndrome-Associated Protein, Is Critical for Retinogenesis and Elaboration of Mouse Photoreceptor Outer Segments. / 20.02.2019 / PubMed / Full text

ARNTL

Is the aging human ovary still ticking?: Expression of clock-genes in luteinized granulosa cells of young and older women. / 21.11.2018 / PubMed / Full text

ARNTL2

Is the aging human ovary still ticking?: Expression of clock-genes in luteinized granulosa cells of young and older women. / 21.11.2018 / PubMed / Full text

ARRB2

Age-dependent effects of dopamine receptor inactivation on cocaine-induced behaviors in male rats: Evidence of dorsal striatal D2 receptor supersensitivity. / 12.2019 / PubMed / Full text

ARSA

Mendelian adult-onset leukodystrophy genes in Alzheimer's disease: critical influence of CSF1R and NOTCH3. / 06.2018 / PubMed / Full text

ASB3

Longitudinal analysis of bronchodilator response in asthmatics and effect modification of age-related trends by genotype. / 02.2019 / PubMed / Full text

ASB7

ASB7 Is a Novel Regulator of Cytoskeletal Organization During Oocyte Maturation. / 2020 / PubMed / Full text

ASIP

Efficacy of an agonist of α-MSH, the palmitoyl tetrapeptide-20, in hair pigmentation. / 10.2018 / PubMed / Full text

ASMT

The influence of ageing on the extrapineal melatonin synthetic pathway. / 09.2018 / PubMed / Full text

ASPN

The association between higher social support and lower depressive symptoms among aging services clients is attenuated at higher levels of functional impairment. / 10.2015 / PubMed / Full text

ATG10

Genetic associations with age of menopause in familial longevity. / 10.2019 / PubMed / Full text

ATG13

Rapamycin reverses age-related increases in mitochondrial ROS production at complex I, oxidative stress, accumulation of mtDNA fragments inside nuclear DNA, and lipofuscin level, and increases autophagy, in the liver of middle-aged mice. / 10.2016 / PubMed / Full text

ATG16L1

The ATG5-binding and coiled coil domains of ATG16L1 maintain autophagy and tissue homeostasis in mice independently of the WD domain required for LC3-associated phagocytosis. / 04.2019 / PubMed / Full text

ATG16L2

Epigallocatechin-3-gallate increases autophagy signaling in resting and unloaded plantaris muscles but selectively suppresses autophagy protein abundance in reloaded muscles of aged rats. / 06.2017 / PubMed / Full text

ATG4B

Impaired autophagic activity and ATG4B deficiency are associated with increased endoplasmic reticulum stress-induced lung injury. / 27.08.2018 / PubMed / Full text

ATG4D

Reduction of Aging-Induced Oxidative Stress and Activation of Autophagy by Bilberry Anthocyanin Supplementation via the AMPK-mTOR Signaling Pathway in Aged Female Rats. / 17.07.2019 / PubMed / Full text

ATMIN

Perturbed hematopoiesis in mice lacking ATMIN. / 20.10.2016 / PubMed / Full text

ATOH1

In Vivo Interplay between p27 , GATA3, ATOH1, and POU4F3 Converts Non-sensory Cells to Hair Cells in Adult Mice. / 11.04.2017 / PubMed / Full text

ATP1A3

The Influence of Na( ), K( )-ATPase on Glutamate Signaling in Neurodegenerative Diseases and Senescence. / 2016 / PubMed / Full text

ATP2B1

Reduced expression of PMCA1 is associated with increased blood pressure with age which is preceded by remodelling of resistance arteries. / 10.2017 / PubMed / Full text

ATP6V0C

A pH probe inhibits senescence in mesenchymal stem cells. / 07.12.2018 / PubMed / Full text

ATP6V1G1

Chemical screening identifies ATM as a target for alleviating senescence. / 06.2017 / PubMed / Full text

ATXN1

Integrative Analysis of Hippocampus Gene Expression Profiles Identifies Network Alterations in Aging and Alzheimer's Disease. / 2018 / PubMed / Full text

ATXN3

Rescue of ATXN3 neuronal toxicity in [i]Caenorhabditis[/i][i]elegans[/i] by chemical modification of endoplasmic reticulum stress. / 19.12.2017 / PubMed / Full text

AURKA

Combined therapies that induce senescence and stabilize p53 block melanoma growth and prompt antitumor immune responses. / 08.2015 / PubMed / Full text

AVPR1A

Introduction of the human AVPR1A gene substantially alters brain receptor expression patterns and enhances aspects of social behavior in transgenic mice. / 08.2014 / PubMed / Full text

BAALC

Relation of BAALC and ERG Gene Expression with Overall Survival in Acute Myeloid Leukemia Cases. / 2015 / PubMed / Full text

BACE2

Lessons from a BACE1 inhibitor trial: off-site but not off base. / 10.2014 / PubMed / Full text

BACH2

Age-related changes in the BACH2 and PRDM1 genes in lymphocytes from healthy donors and chronic lymphocytic leukemia patients. / 17.01.2019 / PubMed / Full text

BAG2

BAG2 Interferes with CHIP-Mediated Ubiquitination of HSP72. / 30.12.2016 / PubMed / Full text

BAP1

The BAP1/ASXL2 Histone H2A Deubiquitinase Complex Regulates Cell Proliferation and Is Disrupted in Cancer. / 27.11.2015 / PubMed / Full text

BAZ1A

Chromatin remodeling factor BAZ1A regulates cellular senescence in both cancer and normal cells. / 15.07.2019 / PubMed / Full text

BAZ2B

Two conserved epigenetic regulators prevent healthy ageing. / 03.2020 / PubMed / Full text

BBS5

Progressive Characterization of Visual Phenotype in Bardet-Biedl Syndrome Mutant Mice. / 01.03.2019 / PubMed / Full text

BCAS1

Hallmarks of the cancer cell of origin: Comparisons with "energetic" cancer stem cells (e-CSCs). / 13.02.2019 / PubMed / Full text

BCL2L1

SIRT6 histone deacetylase functions as a potential oncogene in human melanoma. / 09.2017 / PubMed / Full text

BCL2L11

miRNA expression profiling uncovers a role of miR-302b-3p in regulating skin fibroblasts senescence. / 01.2020 / PubMed / Full text

BCORL1

Age-related mutations associated with clonal hematopoietic expansion and malignancies. / 12.2014 / PubMed / Full text

BFSP1

The oxidized thiol proteome in aging and cataractous mouse and human lens revealed by ICAT labeling. / 04.2017 / PubMed / Full text

BHLHE40

Thyroid hormone induces cellular senescence in prostate cancer cells through induction of DEC1. / 07.2020 / PubMed / Full text

BICD1

Kidney Allograft Telomere Length Is Not Associated with Sex, Recipient Comorbid Conditions, Post-Transplant Infections, or CMV Reactivation. / 28.06.2016 / PubMed / Full text

BMP1

Effects of aging on gene expression and mitochondrial DNA in the equine oocyte and follicle cells. / 07.2015 / PubMed / Full text

BMP5

BMP5 expression in the adult rat brain. / 22.01.2015 / PubMed / Full text

BMX

Inducible Activation of FGFR2 in Adult Mice Promotes Bone Formation After Bone Marrow Ablation. / 11.2017 / PubMed / Full text

BNC1

Basonuclin 1 deficiency causes testicular premature aging: BNC1 cooperates with TAF7L to regulate spermatogenesis. / 22.01.2020 / PubMed / Full text

BNC2

Genetic variants associated with skin aging in the Chinese Han population. / 04.2017 / PubMed / Full text

BOC

Protein Requirements of Elderly Chinese Adults Are Higher than Current Recommendations. / 01.05.2020 / PubMed / Full text

BOK

Comparative proteomic analysis of primordial follicles from ovaries of immature and aged rats. / 2015 / PubMed / Full text

BRD3

Neuroprotective effects of targeting BET proteins for degradation with dBET1 in aged mice subjected to ischemic stroke. / 07.2019 / PubMed / Full text

BRD7

XIAP-associating factor 1, a transcriptional target of BRD7, contributes to endothelial cell senescence. / 02.02.2016 / PubMed / Full text

BRINP1

Absence of BRINP1 in mice causes increase of hippocampal neurogenesis and behavioral alterations relevant to human psychiatric disorders. / 14.02.2014 / PubMed / Full text

BTG1

Tumor cell escape from therapy-induced senescence. / 04.2019 / PubMed / Full text

BTG3

Investigating the specific core genetic-and-epigenetic networks of cellular mechanisms involved in human aging in peripheral blood mononuclear cells. / 23.02.2016 / PubMed / Full text

BTG4

Age-related decrease of IF5/BTG4 in oral and respiratory cavities in mice. / 2015 / PubMed / Full text

BUB1

Links between nucleolar activity, rDNA stability, aneuploidy and chronological aging in the yeast Saccharomyces cerevisiae. / 06.2014 / PubMed / Full text

C1QA

APOE Stabilization by Exercise Prevents Aging Neurovascular Dysfunction and Complement Induction. / 10.2015 / PubMed / Full text

C2CD2

Genetic variants associated with physical performance and anthropometry in old age: a genome-wide association study in the ilSIRENTE cohort. / 20.11.2017 / PubMed / Full text

C4A

Investigation of complement component C4 copy number variation in human longevity. / 2014 / PubMed / Full text

C4B

Investigation of complement component C4 copy number variation in human longevity. / 2014 / PubMed / Full text

C8orf48

Cell senescence abrogates the therapeutic potential of human mesenchymal stem cells in the lethal endotoxemia model. / 07.2014 / PubMed / Full text

CABLES1

CABLES1 Deficiency Impairs Quiescence and Stress Responses of Hematopoietic Stem Cells in Intrinsic and Extrinsic Manners. / 13.08.2019 / PubMed / Full text

CACNA1B

Epigenome-wide exploratory study of monozygotic twins suggests differentially methylated regions to associate with hand grip strength. / 10.2019 / PubMed / Full text

CACNA1C

Epigenetic regulation of L-type voltage-gated Ca channels in mesenteric arteries of aging hypertensive rats. / 05.2017 / PubMed / Full text

CACNA1F

Amyloid Precursor-Like Protein 2 deletion-induced retinal synaptopathy related to congenital stationary night blindness: structural, functional and molecular characteristics. / 08.06.2016 / PubMed / Full text

CACNA1S

Increased calcium channel in the lamina propria of aging rat. / 31.10.2019 / PubMed / Full text

CACNA2D1

Pregabalin can prevent, but not treat, cognitive dysfunction following abdominal surgery in aged rats. / 01.03.2016 / PubMed / Full text

CADM2

GWAS of longevity in CHARGE consortium confirms APOE and FOXO3 candidacy. / 01.2015 / PubMed / Full text

CALHM1

CALHM1 Deletion in Mice Affects Glossopharyngeal Taste Responses, Food Intake, Body Weight, and Life Span. / 07.2015 / PubMed / Full text

CALR

Molecular Pathogenesis of Myeloproliferative Neoplasms: Influence of Age and Gender. / 10.2017 / PubMed / Full text

CAMP

[Study on effect of astragali radix polysaccharides in improving learning and memory functions in aged rats and its mechanism]. / 06.2014 / PubMed

CAMSAP1

Gene Expression Analysis Reveals Novel Gene Signatures Between Young and Old Adults in Human Prefrontal Cortex. / 2018 / PubMed / Full text

CAP2

Targeting MRTF/SRF in CAP2-dependent dilated cardiomyopathy delays disease onset. / 21.03.2019 / PubMed / Full text

CAPN1

Defects in the CAPN1 Gene Result in Alterations in Cerebellar Development and Cerebellar Ataxia in Mice and Humans. / 28.06.2016 / PubMed / Full text

CAPRIN1

Reduced Levels of the Synaptic Functional Regulator FMRP in Dentate Gyrus of the Aging Sprague-Dawley Rat. / 2017 / PubMed / Full text

CARD14

Elderly-Onset Generalized Pustular Psoriasis without a Previous History of Psoriasis Vulgaris. / 05-08.2015 / PubMed / Full text

CASP1

Gene expression of inflammasome components in peripheral blood mononuclear cells (PBMC) of vascular patients increases with age. / 2015 / PubMed / Full text

CASP5

Gene expression of inflammasome components in peripheral blood mononuclear cells (PBMC) of vascular patients increases with age. / 2015 / PubMed / Full text

CASP7

Global Characteristics of CSIG-Associated Gene Expression Changes in Human HEK293 Cells and the Implications for CSIG Regulating Cell Proliferation and Senescence. / 2015 / PubMed / Full text

CASQ2

Single delivery of an adeno-associated viral construct to transfer the CASQ2 gene to knock-in mice affected by catecholaminergic polymorphic ventricular tachycardia is able to cure the disease from birth to advanced age. / 24.06.2014 / PubMed / Full text

CAV1

Broad range metabolomics coupled with network analysis for explaining possible mechanisms of Er-Zhi-Wan in treating liver-kidney Yin deficiency syndrome of Traditional Chinese medicine. / 24.04.2019 / PubMed / Full text

CBSL

Effect of a Community-Based Service Learning Experience in Geriatrics on Internal Medicine Residents and Community Participants. / 09.2017 / PubMed / Full text

CBX3

Biological functions of chromobox (CBX) proteins in stem cell self-renewal, lineage-commitment, cancer and development. / 24.09.2020 / PubMed / Full text

CBX4

Maintenance of Nucleolar Homeostasis by CBX4 Alleviates Senescence and Osteoarthritis. / 26.03.2019 / PubMed / Full text

CBX5

The Ubiquitin-like with PHD and Ring Finger Domains 1 (UHRF1)/DNA Methyltransferase 1 (DNMT1) Axis Is a Primary Regulator of Cell Senescence. / 03.03.2017 / PubMed / Full text

CCAR2

CCAR-1 is a negative regulator of the heat-shock response in Caenorhabditis elegans. / 10.2018 / PubMed / Full text

CCDC102B

Development of a methylation marker set for forensic age estimation using analysis of public methylation data and the Agena Bioscience EpiTYPER system. / 09.2016 / PubMed / Full text

CCDC17

Aberrant DNA Methylation in Keratoacanthoma. / 2016 / PubMed / Full text

CCDC71L

Sequencing of 2 subclinical atherosclerosis candidate regions in 3669 individuals: Cohorts for Heart and Aging Research in Genomic Epidemiology (CHARGE) Consortium Targeted Sequencing Study. / 06.2014 / PubMed / Full text

CCDC88A

Proteomics and metabolomics identify molecular mechanisms of aging potentially predisposing for chronic lymphocytic leukemia. / 02.2018 / PubMed / Full text

CCL1

[Peptides and [[CCL11]] and HMGB1 as molecular markers of aging: literature review and own data]. / 2014 / PubMed

CCL18

Age-specific changes in the molecular phenotype of patients with moderate-to-severe atopic dermatitis. / 07.2019 / PubMed / Full text

CCL26

Dendritic cells from aged subjects contribute to chronic airway inflammation by activating bronchial epithelial cells under steady state. / 11.2014 / PubMed / Full text

CCL28

Age-related chemokine alterations affect IgA secretion and gut immunity in female mice. / 10.2020 / PubMed / Full text

CCL7

Advanced atherosclerosis is associated with inflammation, vascular dysfunction and oxidative stress, but not hypertension. / 02.2017 / PubMed / Full text

CCL8

Human Monocyte Subsets Are Transcriptionally and Functionally Altered in Aging in Response to Pattern Recognition Receptor Agonists. / 15.08.2017 / PubMed / Full text

CCM2

Vascular permeability in cerebral cavernous malformations. / 10.2015 / PubMed / Full text

CCNA1

Age-dependent human β cell proliferation induced by glucagon-like peptide 1 and calcineurin signaling. / 02.10.2017 / PubMed / Full text

CCND2

Oxidative stress-induced miRNAs modulate AKT signaling and promote cellular senescence in uterine leiomyoma. / 10.2018 / PubMed / Full text

CCND3

The effect of aging on the biological and immunological characteristics of periodontal ligament stem cells. / 29.07.2020 / PubMed / Full text

CCR1

Myocardial Infarction Superimposed on Aging: MMP-9 Deletion Promotes M2 Macrophage Polarization. / 04.2016 / PubMed / Full text

CCR10

Cardiac aging is initiated by matrix metalloproteinase-9-mediated endothelial dysfunction. / 15.05.2014 / PubMed / Full text

CCR9

Attenuation of migration properties of CD4 T cells from aged mice correlates with decrease in chemokine receptor expression, response to retinoic acid, and RALDH expression compared to young mice. / 2014 / PubMed / Full text

CCT8

Somatic increase of CCT8 mimics proteostasis of human pluripotent stem cells and extends C. elegans lifespan. / 28.11.2016 / PubMed / Full text

CD209

Comparative analysis of microbial sensing molecules in mucosal tissues with aging. / 03.2018 / PubMed / Full text

CD226

T-cell Immunoglobulin and ITIM Domain Contributes to CD8 T-cell Immunosenescence. / 04.2018 / PubMed / Full text

CD3G

Phenotypic characteristics of aged CD4 CD28 T lymphocytes are determined by changes in the whole-genome DNA methylation pattern. / 04.2017 / PubMed / Full text

CD48

Genetic overexpression of COMP-Ang1 impairs BM microenvironment and induces senescence of BM HSCs. / 15.05.2018 / PubMed / Full text

CD55

Loss of complement regulatory proteins on uninfected erythrocytes in vivax and falciparum malaria anemia. / 15.11.2018 / PubMed / Full text

CD59

Red Blood Cell Homeostasis and Altered Vesicle Formation in Patients With Paroxysmal Nocturnal Hemoglobinuria. / 2019 / PubMed / Full text

CD6

Epigenetic age predictions based on buccal swabs are more precise in combination with cell type-specific DNA methylation signatures. / 05.2016 / PubMed / Full text

CD72

Crucial Role of Increased Arid3a at the Pre-B and Immature B Cell Stages for B1a Cell Generation. / 2019 / PubMed / Full text

CD82

Cell-surface phenotyping identifies CD36 and CD97 as novel markers of fibroblast quiescence in lung fibrosis. / 01.11.2018 / PubMed / Full text

CD83

Human mesothelioma induces defects in dendritic cell numbers and antigen-processing function which predict survival outcomes. / 02.2016 / PubMed / Full text

CDC20

Premature aging syndrome showing random chromosome number instabilities with CDC20 mutation. / 11.2020 / PubMed / Full text

CDC6

A prototypical non-malignant epithelial model to study genome dynamics and concurrently monitor micro-RNAs and proteins in situ during oncogene-induced senescence. / 10.01.2018 / PubMed / Full text

CDC73

Down-regulation of cancer-associated gene CDC73 contributes to cellular senescence. / 23.05.2018 / PubMed / Full text

CDCA3

Expression of CDCA3 Is a Prognostic Biomarker and Potential Therapeutic Target in Non-Small Cell Lung Cancer. / 07.2017 / PubMed / Full text

CDH2

CellBIC: bimodality-based top-down clustering of single-cell RNA sequencing data reveals hierarchical structure of the cell type. / 30.11.2018 / PubMed / Full text

CDO1

The intervention effect of licorice in d-galactose induced aging rats by regulating the taurine metabolic pathway. / 19.09.2018 / PubMed / Full text

CDR2

Neuro-degeneration profile of Alzheimer's patients: A brain morphometry study. / 2017 / PubMed / Full text

CEBPD

Epigenome-wide exploratory study of monozygotic twins suggests differentially methylated regions to associate with hand grip strength. / 10.2019 / PubMed / Full text

CELSR2

Genomewide meta-analysis identifies loci associated with IGF-I and IGFBP-3 levels with impact on age-related traits. / 10.2016 / PubMed / Full text

CEP95

Genome wide association and linkage analyses identified three loci-4q25, 17q23.2, and 10q11.21-associated with variation in leukocyte telomere length: the Long Life Family Study. / 2013 / PubMed / Full text

CER1

Radiographic screening of infants and young children with genetic predisposition for rare malignancies: DICER1 mutations and pleuropulmonary blastoma. / 04.2015 / PubMed / Full text

CFLAR

Senescence-secreted factors activate Myc and sensitize pretransformed cells to TRAIL-induced apoptosis. / 06.2014 / PubMed / Full text

CH25H

Atherosclerosis and Alzheimer--diseases with a common cause? Inflammation, oxysterols, vasculature. / 21.03.2014 / PubMed / Full text

CHAD

Insular cortex lesions, cardiac troponin, and detection of previously unknown atrial fibrillation in acute ischemic stroke: insights from the troponin elevation in acute ischemic stroke study. / 05.2015 / PubMed / Full text

CHEK1

The Ubiquitin-like with PHD and Ring Finger Domains 1 (UHRF1)/DNA Methyltransferase 1 (DNMT1) Axis Is a Primary Regulator of Cell Senescence. / 03.03.2017 / PubMed / Full text

CHEK2

A large-scale CRISPR screen and identification of essential genes in cellular senescence bypass. / 20.06.2019 / PubMed / Full text

CHMP1B

Overexpression of CHMP7 from rapeseed and Arabidopsis causes dwarfism and premature senescence in Arabidopsis. / 01.10.2016 / PubMed / Full text

CHMP2B

Frontotemporal dementia: insights into the biological underpinnings of disease through gene co-expression network analysis. / 24.02.2016 / PubMed / Full text

CHMP7

Overexpression of CHMP7 from rapeseed and Arabidopsis causes dwarfism and premature senescence in Arabidopsis. / 01.10.2016 / PubMed / Full text

CHRDL1

Identification of Human Juvenile Chondrocyte-Specific Factors that Stimulate Stem Cell Growth. / 04.2016 / PubMed / Full text

CHRM4

Novel molecular mechanisms for the adaptogenic effects of herbal extracts on isolated brain cells using systems biology. / 15.11.2018 / PubMed / Full text

CHRNA7

Associations between genetic variations and global motion perception. / 10.2019 / PubMed / Full text

CHRNE

Novel molecular mechanisms for the adaptogenic effects of herbal extracts on isolated brain cells using systems biology. / 15.11.2018 / PubMed / Full text

CHSY1

Loss of Chondroitin Sulfate Modification Causes Inflammation and Neurodegeneration in [i]skt[/i] Mice. / 01.2020 / PubMed / Full text

CIC

Cell-in-cell structures are more potent predictors of outcome than senescence or apoptosis in head and neck squamous cell carcinomas. / 18.01.2017 / PubMed / Full text

CIDEA

Growth hormone receptor expression in human gluteal versus abdominal subcutaneous adipose tissue: Association with body shape. / 05.2016 / PubMed / Full text

CILP

Fibrotic-like changes in degenerate human intervertebral discs revealed by quantitative proteomic analysis. / 03.2016 / PubMed / Full text

CILP2

Fibrotic-like changes in degenerate human intervertebral discs revealed by quantitative proteomic analysis. / 03.2016 / PubMed / Full text

CINP

Neuropathology-driven Whole-genome Sequencing Study Points to Novel Candidate Genes for Healthy Brain Aging. / 01-03.2019 / PubMed / Full text

CIP2A

Inhibition of CIP2A attenuates tumor progression by inducing cell cycle arrest and promoting cellular senescence in hepatocellular carcinoma. / 08.01.2018 / PubMed / Full text

CITED2

Downregulation of CITED2 contributes to TGFβ-mediated senescence of tendon-derived stem cells. / 04.2017 / PubMed / Full text

CIZ1

DNA damage and neurodegenerative phenotypes in aged Ciz1 null mice. / 02.2018 / PubMed / Full text

CLCN6

DNA methylation levels at individual age-associated CpG sites can be indicative for life expectancy. / 02.2016 / PubMed / Full text

CLEC4E

Comparative analysis of microbial sensing molecules in mucosal tissues with aging. / 03.2018 / PubMed / Full text

CLSTN2

Investigating the influence of KIBRA and CLSTN2 genetic polymorphisms on cross-sectional and longitudinal measures of memory performance and hippocampal volume in older individuals. / 11.2015 / PubMed / Full text

CMA1

Extended Multiplexing of Tandem Mass Tags (TMT) Labeling Reveals Age and High Fat Diet Specific Proteome Changes in Mouse Epididymal Adipose Tissue. / 05.2017 / PubMed / Full text

CNGA3

DNA methylation-based age prediction from saliva: High age predictability by combination of 7 CpG markers. / 07.2017 / PubMed / Full text

CNOT6

miR-29c-3p promotes senescence of human mesenchymal stem cells by targeting CNOT6 through p53-p21 and p16-pRB pathways. / 04.2016 / PubMed / Full text

CNTRL

Antioxidant status, lipid and color stability of aged beef from grazing steers supplemented with corn grain and increasing levels of flaxseed. / 01.2016 / PubMed / Full text

COL12A1

Genetic associations with age of menopause in familial longevity. / 10.2019 / PubMed / Full text

COL13A1

[Alu insertion-deletion polymorphism of COL13A1 and LAMA2 genes: The analysis of association with longevity]. / 10.2016 / PubMed

COL15A1

Smooth muscle cell-specific deletion of [i]Col15a1[/i] unexpectedly leads to impaired development of advanced atherosclerotic lesions. / 01.05.2017 / PubMed / Full text

COL17A1

Hair follicle aging is driven by transepidermal elimination of stem cells via COL17A1 proteolysis. / 05.02.2016 / PubMed / Full text

COL4A3

Frequency of COL4A3/COL4A4 mutations amongst families segregating glomerular microscopic hematuria and evidence for activation of the unfolded protein response. Focal and segmental glomerulosclerosis is a frequent development during ageing. / 2014 / PubMed / Full text

COL7A1

Biological Effects Induced by Specific Advanced Glycation End Products in the Reconstructed Skin Model of Aging. / 2015 / PubMed / Full text

COQ5

Reduction in the levels of CoQ biosynthetic proteins is related to an increase in lifespan without evidence of hepatic mitohormesis. / 18.09.2018 / PubMed / Full text

COQ6

Reduction in the levels of CoQ biosynthetic proteins is related to an increase in lifespan without evidence of hepatic mitohormesis. / 18.09.2018 / PubMed / Full text

COQ9

Reduction in the levels of CoQ biosynthetic proteins is related to an increase in lifespan without evidence of hepatic mitohormesis. / 18.09.2018 / PubMed / Full text

COX7A2

Proteomics Analysis to Identify and Characterize the Biomarkers and Physical Activities of Non-Frail and Frail Older Adults. / 2017 / PubMed / Full text

CPA3

Extended Multiplexing of Tandem Mass Tags (TMT) Labeling Reveals Age and High Fat Diet Specific Proteome Changes in Mouse Epididymal Adipose Tissue. / 05.2017 / PubMed / Full text

CPB2

Characterization of Clostridium perfringens in the feces of adult horses and foals with acute enterocolitis. / 01.2014 / PubMed / Full text

CPNE1

Prevalent intron retention fine-tunes gene expression and contributes to cellular senescence. / 04.12.2020 / PubMed / Full text

CPSF1

Genome-wide association study for lactation persistency, female fertility, longevity, and lifetime profit index traits in Holstein dairy cattle. / 02.2017 / PubMed / Full text

CPT1A

Alteration of fatty acid oxidation by increased CPT1A on replicative senescence of placenta-derived mesenchymal stem cells. / 03.01.2020 / PubMed / Full text

CRBN

Using proteolysis-targeting chimera technology to reduce navitoclax platelet toxicity and improve its senolytic activity. / 24.04.2020 / PubMed / Full text

CREB1

Arginine Methyltransferase PRMT8 Provides Cellular Stress Tolerance in Aging Motoneurons. / 29.08.2018 / PubMed / Full text

CREBL2

Global Characteristics of CSIG-Associated Gene Expression Changes in Human HEK293 Cells and the Implications for CSIG Regulating Cell Proliferation and Senescence. / 2015 / PubMed / Full text

CREG1

CREG1 ameliorates myocardial fibrosis associated with autophagy activation and Rab7 expression. / 02.2015 / PubMed / Full text

CRHR1

Koolen-de Vries Syndrome: Clinical Report of an Adult and Literature Review. / 2016 / PubMed / Full text

CRISPLD2

A large-scale CRISPR screen and identification of essential genes in cellular senescence bypass. / 20.06.2019 / PubMed / Full text

CRK

Crack-cocaine dependence and aging: effects on working memory. / 03.2016 / PubMed / Full text

CRTC1

TRPV1 pain receptors regulate longevity and metabolism by neuropeptide signaling. / 22.05.2014 / PubMed / Full text

CRTC3

A nutrigenomics approach for the study of anti-aging interventions: olive oil phenols and the modulation of gene and microRNA expression profiles in mouse brain. / 03.2017 / PubMed / Full text

CRYAA

Polymorphism rs7278468 is associated with Age-related cataract through decreasing transcriptional activity of the CRYAA promoter. / 17.03.2016 / PubMed / Full text

CRYL1

Lipid and Alzheimer's disease genes associated with healthy aging and longevity in healthy oldest-old. / 28.03.2017 / PubMed / Full text

CSAD

The intervention effect of licorice in d-galactose induced aging rats by regulating the taurine metabolic pathway. / 19.09.2018 / PubMed / Full text

CSF1

Pleiotropic effects of extended blockade of CSF1R signaling in adult mice. / 08.2014 / PubMed / Full text

CSF3R

Both Granulocytic and Non-Granulocytic Blood Cells Are Affected in Patients with Severe Congenital Neutropenia and Their Non-Neutropenic Family Members: An Evaluation of Morphology, Function, and Cell Death / 13.11.2018 / PubMed / Full text

CSN2

Autophagic homeostasis is required for the pluripotency of cancer stem cells. / 02.2017 / PubMed / Full text

CSNK1D

DNA methylation-based forensic age prediction using artificial neural networks and next generation sequencing. / 05.2017 / PubMed / Full text

CST3

Improved lipids, diastolic pressure and kidney function are potential contributors to familial longevity: a study on 60 Chinese centenarian families. / 25.02.2016 / PubMed / Full text

CSTF2T

Genome wide association and linkage analyses identified three loci-4q25, 17q23.2, and 10q11.21-associated with variation in leukocyte telomere length: the Long Life Family Study. / 2013 / PubMed / Full text

CTNS

Reducing INS-IGF1 signaling protects against non-cell autonomous vesicle rupture caused by SNCA spreading. / 05.2020 / PubMed / Full text

CTSA

A CTSA-based consultation service to advance research on special and underserved populations. / 16.01.2020 / PubMed / Full text

CTSC

Frontotemporal dementia: insights into the biological underpinnings of disease through gene co-expression network analysis. / 24.02.2016 / PubMed / Full text

CTSD

Serum levels of cathepsin D, sirtuin1, and endothelial nitric oxide synthase are correlatively reduced in elderly healthy people. / 08.2016 / PubMed / Full text

CTSK

Transcriptome Analysis of B Cell Immune Functions in Periodontitis: Mucosal Tissue Responses to the Oral Microbiome in Aging. / 2016 / PubMed / Full text

CTSS

SIRT6 histone deacetylase functions as a potential oncogene in human melanoma. / 09.2017 / PubMed / Full text

CUBN

A roadmap for the genetic analysis of renal aging. / 10.2015 / PubMed / Full text

CUL3

KLHL22 activates amino-acid-dependent mTORC1 signalling to promote tumorigenesis and ageing. / 05.2018 / PubMed / Full text

CUL4B

CUL4B impedes stress-induced cellular senescence by dampening a p53-reactive oxygen species positive feedback loop. / 02.2015 / PubMed / Full text

CUX1

Identification of key genes and transcription factors in aging mesenchymal stem cells by DNA microarray data. / 15.04.2019 / PubMed / Full text

CXCL14

Identification of genes associated with endometrial cell aging. / 01.12.2020 / PubMed / Full text

CXCL17

[Age-related aspects of the involvement of heat shock proteins in the pathogenesis of osteoarthritis]. / 2017 / PubMed

CXCR6

CXCR6 Inhibits Hepatocarcinogenesis by Promoting Natural Killer T- and CD4 T-Cell-Dependent Control of Senescence. / 05.2019 / PubMed / Full text

CXXC5

Length of paternal lifespan is manifested in the DNA methylome of their nonagenarian progeny. / 13.10.2015 / PubMed / Full text

CYB5R3

Overexpression of CYB5R3 and NQO1, two NAD -producing enzymes, mimics aspects of caloric restriction. / 08.2018 / PubMed / Full text

CYCS

The Impact of Age and Sex in DLBCL: Systems Biology Analyses Identify Distinct Molecular Changes and Signaling Networks. / 2015 / PubMed / Full text

CYP11B1

Intratumoral heterogeneity of the tumor cells based on in situ cortisol excess in cortisol-producing adenomas; ∼An association among morphometry, genotype and cellular senescence∼. / 11.2020 / PubMed / Full text

CYP26A1

Genetics of Human Longevity From Incomplete Data: New Findings From the Long Life Family Study. / 08.10.2018 / PubMed / Full text

CYP26B1

Increased Retinoic Acid Catabolism in Olfactory Sensory Neurons Activates Dormant Tissue-Specific Stem Cells and Accelerates Age-Related Metaplasia. / 20.05.2020 / PubMed / Full text

CYP2B6

Developmental Expression of CYP2B6: A Comprehensive Analysis of mRNA Expression, Protein Content and Bupropion Hydroxylase Activity and the Impact of Genetic Variation. / 07.2016 / PubMed / Full text

CYP2U1

Genetic variants associated with lung function: the long life family study. / 01.11.2014 / PubMed / Full text

CYP4X1

Sex- and age-dependent gene expression in human liver: An implication for drug-metabolizing enzymes. / 02.2017 / PubMed / Full text

CYP8B1

Synergic hypocholesterolaemic effect of n-3 PUFA and oestrogen by modulation of hepatic cholesterol metabolism in female rats. / 14.12.2015 / PubMed / Full text

DAPK2

SerThr-PhosphoProteome of Brain from Aged PINK1-KO A53T-SNCA Mice Reveals pT1928-MAP1B and pS3781-ANK2 Deficits, as Hub between Autophagy and Synapse Changes. / 04.07.2019 / PubMed / Full text

DAZL

DAZL Regulates Germ Cell Survival through a Network of PolyA-Proximal mRNA Interactions. / 30.10.2018 / PubMed / Full text

DCAF17

Deletion of DDB1- and CUL4- associated factor-17 (Dcaf17) gene causes spermatogenesis defects and male infertility in mice. / 15.06.2018 / PubMed / Full text

DCAF7

Genome wide association and linkage analyses identified three loci-4q25, 17q23.2, and 10q11.21-associated with variation in leukocyte telomere length: the Long Life Family Study. / 2013 / PubMed / Full text

DCHS1

The atypical cadherin Dachsous1 localizes to the base of the ciliary apparatus in airway epithelia. / 13.05.2016 / PubMed / Full text

DCLRE1C

Polymorphisms of the DNA repair gene EXO1 modulate cognitive aging in old adults in a Taiwanese population. / 06.2019 / PubMed / Full text

DCTN1

Alteration of Motor Protein Expression Involved in Bidirectional Transport in Peripheral Blood Mononuclear Cells of Patients with Amyotrophic Lateral Sclerosis. / 2016 / PubMed / Full text

DCTN2

Dynactin pathway-related gene expression is altered by aging, but not by vitrification. / 09.2019 / PubMed / Full text

DCTN6

Dynactin pathway-related gene expression is altered by aging, but not by vitrification. / 09.2019 / PubMed / Full text

DDI2

Androgen receptor polyglutamine expansion drives age-dependent quality control defects and muscle dysfunction. / 01.08.2018 / PubMed / Full text

DDIT3

Inhibition of glioma growth by flavokawain B is mediated through endoplasmic reticulum stress induced autophagy. / 2018 / PubMed / Full text

DDR1

Age-related modifications of type I collagen impair DDR1-induced apoptosis in non-invasive breast carcinoma cells. / 2018 / PubMed / Full text

DEFB1

Association of Polymorphisms in Innate Immunity Genes TLR9 and DEFB1 with Human Longevity. / 05.2015 / PubMed / Full text

DEPDC5

KLHL22 activates amino-acid-dependent mTORC1 signalling to promote tumorigenesis and ageing. / 05.2018 / PubMed / Full text

DEPTOR

DEPTOR at the Nexus of Cancer, Metabolism, and Immunity. / 01.07.2018 / PubMed / Full text

DGAT2

Expression of lipogenic markers is decreased in subcutaneous adipose tissue and adipocytes of older women and is negatively linked to GDF15 expression. / 08.2019 / PubMed / Full text

DHCR7

Environmental and genetic determinants of vitamin D status among older adults in London, UK. / 11.2016 / PubMed / Full text

DHFR

Excessive folic acid intake and relation to adverse health outcome. / 07.2016 / PubMed / Full text

DHRS2

Acute HSF1 depletion induces cellular senescence through the MDM2-p53-p21 pathway in human diploid fibroblasts. / 08.05.2018 / PubMed / Full text

DHX57

Genetic variants near MLST8 and DHX57 affect the epigenetic age of the cerebellum. / 02.02.2016 / PubMed / Full text

DIP2A

Blocking the FSTL1-DIP2A Axis Improves Anti-tumor Immunity. / 14.08.2018 / PubMed / Full text

DKK3

Phosphatase WIP1 regulates adult neurogenesis and WNT signaling during aging. / 07.2014 / PubMed / Full text

DLAT

Proteomics and metabolomics identify molecular mechanisms of aging potentially predisposing for chronic lymphocytic leukemia. / 02.2018 / PubMed / Full text

DLC1

Resveratrol promotes oxidative stress to drive DLC1 mediated cellular senescence in cancer cells. / 15.09.2018 / PubMed / Full text

DLGAP2

Cross-Species Analyses Identify Dlgap2 as a Regulator of Age-Related Cognitive Decline and Alzheimer's Dementia. / 01.09.2020 / PubMed / Full text

DLL1

MiR-34a Enhances Chondrocyte Apoptosis, Senescence and Facilitates Development of Osteoarthritis by Targeting DLL1 and Regulating PI3K/AKT Pathway. / 2018 / PubMed / Full text

DLL4

Dynamic regulation of NOTCH1 activation and Notch ligand expression in human thymus development. / 13.08.2018 / PubMed / Full text

DLX2

A gain-of-function senescence bypass screen identifies the homeobox transcription factor DLX2 as a regulator of ATM-p53 signaling. / 01.02.2016 / PubMed / Full text

DMPK

Expanded CUG Repeats Trigger Disease Phenotype and Expression Changes through the RNAi Machinery in C. elegans. / 19.04.2019 / PubMed / Full text

DMRT1

The Jak-STAT target Chinmo prevents sex transformation of adult stem cells in the Drosophila testis niche. / 24.11.2014 / PubMed / Full text

DNAJB9

DNAJB9 Inhibits p53-Dependent Oncogene-Induced Senescence and Induces Cell Transformation. / 30.04.2020 / PubMed / Full text

DNAJC2

ZRF1 is a novel S6 kinase substrate that drives the senescence programme. / 15.03.2017 / PubMed / Full text

DNM1

Increased Degradation Rates in the Components of the Mitochondrial Oxidative Phosphorylation Chain in the Cerebellum of Old Mice. / 2018 / PubMed / Full text

DNM2

Tamoxifen prolongs survival and alleviates symptoms in mice with fatal X-linked myotubular myopathy. / 19.11.2018 / PubMed / Full text

DNMT3L

Transient DNMT3L Expression Reinforces Chromatin Surveillance to Halt Senescence Progression in Mouse Embryonic Fibroblast. / 2020 / PubMed / Full text

DPP6

A novel structure associated with aging is augmented in the DPP6-KO mouse brain. / 23.11.2020 / PubMed / Full text

DPYSL2

Alcohol drinking exacerbates neural and behavioral pathology in the 3xTg-AD mouse model of Alzheimer's disease. / 2019 / PubMed / Full text

DRAM2

SIRT6 histone deacetylase functions as a potential oncogene in human melanoma. / 09.2017 / PubMed / Full text

DRD1

Impact of dopamine-related genetic variants on physical activity in old age - a cohort study. / 24.05.2020 / PubMed / Full text

DSC1

HDLs and the pathogenesis of atherosclerosis. / 05.2018 / PubMed / Full text

DSG1

Genetic effects on information processing speed are moderated by age--converging results from three samples. / 06.2014 / PubMed / Full text

DSG2

Association and interaction effects of Alzheimer's disease-associated genes and lifestyle on cognitive aging in older adults in a Taiwanese population. / 11.04.2017 / PubMed / Full text

DSPP

Effects of [i]p[/i]-Cresol on Senescence, Survival, Inflammation, and Odontoblast Differentiation in Canine Dental Pulp Stem Cells. / 21.09.2020 / PubMed / Full text

DTL

Targeting DTL induces cell cycle arrest and senescence and suppresses cell growth and colony formation through TPX2 inhibition in human hepatocellular carcinoma cells. / 2018 / PubMed / Full text

DTNBP1

Genetic Biomarkers on Age-Related Cognitive Decline. / 2017 / PubMed / Full text

DTX1

Analysis of diarrhetic shellfish poisoning toxins and pectenotoxin-2 in the bottlenose dolphin (Tursiops truncatus) by liquid chromatography-tandem mass spectrometry. / 16.10.2015 / PubMed / Full text

DTX2

Analysis of diarrhetic shellfish poisoning toxins and pectenotoxin-2 in the bottlenose dolphin (Tursiops truncatus) by liquid chromatography-tandem mass spectrometry. / 16.10.2015 / PubMed / Full text

DUOX1

Lifespan extension by peroxidase and dual oxidase-mediated ROS signaling through pyrroloquinoline quinone in [i]C. elegans[/i]. / 01.08.2017 / PubMed / Full text

DUOX2

Lifespan extension by peroxidase and dual oxidase-mediated ROS signaling through pyrroloquinoline quinone in [i]C. elegans[/i]. / 01.08.2017 / PubMed / Full text

DUSP1

miR-1468-3p Promotes Aging-Related Cardiac Fibrosis. / 05.06.2020 / PubMed / Full text

DUSP2

Aging Increases Hippocampal DUSP2 by a Membrane Cholesterol Loss-Mediated RTK/p38MAPK Activation Mechanism. / 2019 / PubMed / Full text

DUSP6

Protection of CD4 T cells from hepatitis C virus infection-associated senescence via ΔNp63-miR-181a-Sirt1 pathway. / 11.2016 / PubMed / Full text

DUSP8

MiR-21-5p/dual-specificity phosphatase 8 signalling mediates the anti-inflammatory effect of haem oxygenase-1 in aged intracerebral haemorrhage rats. / 12.2019 / PubMed / Full text

DUT

Simultaneous liquefaction, saccharification, and fermentation of L-lactic acid using aging paddy rice with hull by an isolated thermotolerant Enterococcus faecalis DUT1805. / 09.2020 / PubMed / Full text

DVL1

DNA methylation patterns associated with oxidative stress in an ageing population. / 25.11.2016 / PubMed / Full text

DYNC2H1

Role for intraflagellar transport in building a functional transition zone. / 12.2018 / PubMed / Full text

ECE1

Ferulic Acid Suppresses Amyloid [i]β[/i] Production in the Human Lens Epithelial Cell Stimulated with Hydrogen Peroxide. / 2017 / PubMed / Full text

ECRG4

ECRG4: a new potential target in precision medicine. / 10.2019 / PubMed / Full text

ECSIT

Longevity-related molecular pathways are subject to midlife "switch" in humans. / 08.2019 / PubMed / Full text

EDAR

Pharmacological stimulation of Edar signaling in the adult enhances sebaceous gland size and function. / 02.2015 / PubMed / Full text

EDEM1

Expression of lipogenic markers is decreased in subcutaneous adipose tissue and adipocytes of older women and is negatively linked to GDF15 expression. / 08.2019 / PubMed / Full text

EDF1

Silencing of FOREVER YOUNG FLOWER Like Genes from Phalaenopsis Orchids Promotes Flower Senescence and Abscission. / 25.11.2020 / PubMed / Full text

EDN1

Dexamethasone downregulates SIRT1 and IL6 and upregulates EDN1 genes in stem cells derived from gingivae via the AGE/RAGE pathway. / 03.2018 / PubMed / Full text

EDNRB

Deriving human ENS lineages for cell therapy and drug discovery in Hirschsprung disease. / 03.03.2016 / PubMed / Full text

EED

Economic evaluations of eHealth technologies: A systematic review. / 2018 / PubMed / Full text

EEF1A1

Bioinformatics analysis of proteomics profiles in senescent human primary proximal tubule epithelial cells. / 01.04.2016 / PubMed / Full text

EEF2

Bioinformatics analysis of proteomics profiles in senescent human primary proximal tubule epithelial cells. / 01.04.2016 / PubMed / Full text

EFCAB5

Genetic architecture of epigenetic and neuronal ageing rates in human brain regions. / 18.05.2017 / PubMed / Full text

EFNB1

Activation of EphA4 and EphB2 Reverse Signaling Restores the Age-Associated Reduction of Self-Renewal, Migration, and Actin Turnover in Human Tendon Stem/Progenitor Cells. / 2015 / PubMed / Full text

EFNB2

Cartilage-specific deletion of ephrin-B2 in mice results in early developmental defects and an osteoarthritis-like phenotype during aging in vivo. / 15.03.2016 / PubMed / Full text

EGR2

Age-related impairment of bones' adaptive response to loading in mice is associated with sex-related deficiencies in osteoblasts but no change in osteocytes. / 08.2014 / PubMed / Full text

EID3

Upregulation of EID3 sensitizes breast cancer cells to ionizing radiation-induced cellular senescence. / 11.2018 / PubMed / Full text

EIF2B2

Mendelian adult-onset leukodystrophy genes in Alzheimer's disease: critical influence of CSF1R and NOTCH3. / 06.2018 / PubMed / Full text

EIF2B3

Mendelian adult-onset leukodystrophy genes in Alzheimer's disease: critical influence of CSF1R and NOTCH3. / 06.2018 / PubMed / Full text

EIF2B4

Mendelian adult-onset leukodystrophy genes in Alzheimer's disease: critical influence of CSF1R and NOTCH3. / 06.2018 / PubMed / Full text

EIF4E

Transcriptomic evidence that insulin signalling pathway regulates the ageing of subterranean termite castes. / 18.05.2020 / PubMed / Full text

ELANE

Both Granulocytic and Non-Granulocytic Blood Cells Are Affected in Patients with Severe Congenital Neutropenia and Their Non-Neutropenic Family Members: An Evaluation of Morphology, Function, and Cell Death / 13.11.2018 / PubMed / Full text

ELK1

Tocotrienol-rich fraction prevents cellular aging by modulating cell proliferation signaling pathways. / 2015 / PubMed / Full text

ELL

Exceptional Longevity and Polygenic Risk for Cardiovascular Health. / 18.03.2019 / PubMed / Full text

ELN

Curcumin enhances the production of major structural components of elastic fibers, elastin, and fibrillin-1, in normal human fibroblast cells. / 2015 / PubMed / Full text

ELOVL6

An Adult Drosophila Glioma Model for Studying Pathometabolic Pathways of Gliomagenesis. / 06.2019 / PubMed / Full text

EMILIN2

Extended Multiplexing of Tandem Mass Tags (TMT) Labeling Reveals Age and High Fat Diet Specific Proteome Changes in Mouse Epididymal Adipose Tissue. / 05.2017 / PubMed / Full text

EML6

Cell fate regulation by reticulon-4 in human prostate cancers. / 07.2019 / PubMed / Full text

ENPEP

Extended Multiplexing of Tandem Mass Tags (TMT) Labeling Reveals Age and High Fat Diet Specific Proteome Changes in Mouse Epididymal Adipose Tissue. / 05.2017 / PubMed / Full text

EOMES

Eomesodermin Expression in CD4 T Cells Restricts Peripheral Foxp3 Induction. / 15.11.2015 / PubMed / Full text

EPG5

Genome-wide scan of depressive symptomatology in two representative cohorts in the United States and the United Kingdom. / 05.2018 / PubMed / Full text

ERAP1

Epigenome-wide exploratory study of monozygotic twins suggests differentially methylated regions to associate with hand grip strength. / 10.2019 / PubMed / Full text

ERBB3

[The expression of differential and matrix remodelling factors in human buccal epithelium in aging]. / 2013 / PubMed

ERBB4

Overexpression of ERBB4 rejuvenates aged mesenchymal stem cells and enhances angiogenesis via PI3K/AKT and MAPK/ERK pathways. / 03.2019 / PubMed / Full text

ERCC5

Identification of a ERCC5 c.2333T>C (L778P) Variant in Two Tunisian Siblings With Mild Xeroderma Pigmentosum Phenotype. / 2019 / PubMed / Full text

ERCC6

Two Cockayne Syndrome patients with a novel splice site mutation - clinical and metabolic analyses. / 10.2018 / PubMed / Full text

ERCC8

Analysis of somatic mutations identifies signs of selection during in vitro aging of primary dermal fibroblasts. / 12.2019 / PubMed / Full text

EREG

Effects of aging on gene expression and mitochondrial DNA in the equine oocyte and follicle cells. / 07.2015 / PubMed / Full text

ESCO1

Global Characteristics of CSIG-Associated Gene Expression Changes in Human HEK293 Cells and the Implications for CSIG Regulating Cell Proliferation and Senescence. / 2015 / PubMed / Full text

ESPL1

Identification and genomic analysis of pedigrees with exceptional longevity identifies candidate rare variants. / 09.2020 / PubMed / Full text

ESRG

MYC Releases Early Reprogrammed Human Cells from Proliferation Pause via Retinoblastoma Protein Inhibition. / 10.04.2018 / PubMed / Full text

ETFA

Effect of testosterone on markers of mitochondrial oxidative phosphorylation and lipid metabolism in muscle of aging men with subnormal bioavailable testosterone. / 07.2014 / PubMed / Full text

ETV5

miR-19b-3p induces cell proliferation and reduces heterochromatin-mediated senescence through PLZF in goat male germline stem cells. / 06.2018 / PubMed / Full text

ETV6

FOXO1 and ETV6 genes may represent novel regulators of splicing factor expression in cellular senescence. / 01.2019 / PubMed / Full text

EVC

Decreased centrality of subcortical regions during the transition to adolescence: a functional connectivity study. / 01.01.2015 / PubMed / Full text

EVL

Health Years in Total: A New Health Objective Function for Cost-Effectiveness Analysis. / 01.2020 / PubMed / Full text

EXD2

EXD2 governs germ stem cell homeostasis and lifespan by promoting mitoribosome integrity and translation. / 02.2018 / PubMed / Full text

EXOC3L2

Gene-based aggregate SNP associations between candidate AD genes and cognitive decline. / 04.2016 / PubMed / Full text

EXOC7

PTBP1-Mediated Alternative Splicing Regulates the Inflammatory Secretome and the Pro-tumorigenic Effects of Senescent Cells. / 09.07.2018 / PubMed / Full text

EYA4

A Large Genome-Wide Association Study of Age-Related Hearing Impairment Using Electronic Health Records. / 10.2016 / PubMed / Full text

EYS

Ablation of EYS in zebrafish causes mislocalisation of outer segment proteins, F-actin disruption and cone-rod dystrophy. / 05.04.2017 / PubMed / Full text

EZR

Proteomic analysis of six- and twelve-month hippocampus and cerebellum in a murine Down syndrome model. / 03.2018 / PubMed / Full text

F10

Hydroalcoholic extract of Spartium junceum L. flowers inhibits growth and melanogenesis in B16-F10 cells by inducing senescence. / 15.07.2018 / PubMed / Full text

F11R

[Adhesion molecule JAM-A, its function and mechanism of epigenetic regulation]. / 2015 / PubMed

F12

Multigenerational effects of carbendazim in Daphnia magna: From a subcellular to a population level. / 02.2019 / PubMed / Full text

F8

Correlations between the signal complexity of cerebral and cardiac electrical activity: a multiscale entropy analysis. / 2014 / PubMed / Full text

FA2H

C. Elegans Fatty Acid Two-Hydroxylase Regulates Intestinal Homeostasis by Affecting Heptadecenoic Acid Production. / 2018 / PubMed / Full text

FABP1

Expression of digestive enzyme and intestinal transporter genes during chronic heat stress in the thermally manipulated broiler chicken. / 01.09.2019 / PubMed / Full text

FADS1

Aging and FADS1 polymorphisms decrease the biosynthetic capacity of long-chain PUFAs: A human trial using [U- C]linoleic acid. / 09.2019 / PubMed / Full text

FADS2

Genetic determinants of P wave duration and PR segment. / 08.2014 / PubMed / Full text

FAM13A

Trade-offs in aging lung diseases: a review on shared but opposite genetic risk variants in idiopathic pulmonary fibrosis, lung cancer and chronic obstructive pulmonary disease. / 05.2018 / PubMed / Full text

FANCC

Fanconi Anemia complementation group C protein in metabolic disorders. / 21.06.2018 / PubMed / Full text

FAR2

FAR2 is associated with kidney disease in mice and humans. / 01.08.2018 / PubMed / Full text

FAT4

Neuron-specific knockdown of the Drosophila fat induces reduction of life span, deficient locomotive ability, shortening of motoneuron terminal branches and defects in axonal targeting. / 07.2017 / PubMed / Full text

FBXO28

MYC Modulation around the CDK2/p27/SKP2 Axis. / 30.06.2017 / PubMed / Full text

FBXO32

Endophilin-A Deficiency Induces the Foxo3a-Fbxo32 Network in the Brain and Causes Dysregulation of Autophagy and the Ubiquitin-Proteasome System. / 18.10.2016 / PubMed / Full text

FBXO46

The SCF ubiquitin ligase complex mediates degradation of the tumor suppressor FBXO31 and thereby prevents premature cellular senescence. / 19.10.2018 / PubMed / Full text

FBXO7

The FBXO7 homologue nutcracker and binding partner PI31 in Drosophila melanogaster models of Parkinson's disease. / 01.2017 / PubMed / Full text

FBXW7

MYC Modulation around the CDK2/p27/SKP2 Axis. / 30.06.2017 / PubMed / Full text

FCER1G

A Microglial Signature Directing Human Aging and Neurodegeneration-Related Gene Networks. / 2019 / PubMed / Full text

FCGR2A

Impact of C-reactive protein on osteo-/chondrogenic transdifferentiation and calcification of vascular smooth muscle cells. / 03.08.2019 / PubMed / Full text

FCGR3A

Genomic regulation of senescence and innate immunity signaling in the retinal pigment epithelium. / 06.2015 / PubMed / Full text

FDPS

Targeting the phospholipase A2 receptor ameliorates premature aging phenotypes. / 12.2018 / PubMed / Full text

FDXR

The aged testis. A good model to find proteins involved in age-related changes of testis by proteomic analysis. / 01-02.2014 / PubMed

FER

Tracking the recognition of static and dynamic facial expressions of emotion across the life span. / 04.09.2018 / PubMed / Full text

FER1L6

Genome-wide association study and annotating candidate gene networks affecting age at first calving in Nellore cattle. / 12.2017 / PubMed / Full text

FEZ1

Disruption to schizophrenia-associated gene Fez1 in the hippocampus of HDAC11 knockout mice. / 19.09.2017 / PubMed / Full text

FGB

[Clinical and genetic characteristics of long-livers in Moscow region]. / 2013 / PubMed

FGF14

Fibroblast Growth Factor 14 Modulates the Neurogenesis of Granule Neurons in the Adult Dentate Gyrus. / 12.2016 / PubMed / Full text

FGFBP1

Muscle Fibers Secrete FGFBP1 to Slow Degeneration of Neuromuscular Synapses during Aging and Progression of ALS. / 04.01.2017 / PubMed / Full text

FGG

Candidate SNP associations of optimism and resilience in older adults: exploratory study of 935 community-dwelling adults. / 10.2014 / PubMed / Full text

FGL2

Developmental expression of B cell molecules in equine lymphoid tissues. / 01.2017 / PubMed / Full text

FIG4

Knockdown of the Drosophila FIG4 induces deficient locomotive behavior, shortening of motor neuron, axonal targeting aberration, reduction of life span and defects in eye development. / 03.2016 / PubMed / Full text

FIGNL1

Comparative proteomic analysis of primordial follicles from ovaries of immature and aged rats. / 2015 / PubMed / Full text

FKRP

Progressive Dystrophic Pathology in Diaphragm and Impairment of Cardiac Function in FKRP P448L Mutant Mice. / 2016 / PubMed / Full text

FLNA

SQSTM1/p62 mediates crosstalk between autophagy and the UPS in DNA repair. / 02.10.2016 / PubMed / Full text

FLT3

Sequential acquisition of mutations in myelodysplastic syndromes. / 2017 / PubMed / Full text

FMN2

Genomic regulation of senescence and innate immunity signaling in the retinal pigment epithelium. / 06.2015 / PubMed / Full text

FMO1

Functional analysis and transcriptional output of the Göttingen minipig genome. / 14.11.2015 / PubMed / Full text

FMO3

Genetic and Nongenetic Factors Associated with Protein Abundance of Flavin-Containing Monooxygenase 3 in Human Liver. / 11.2017 / PubMed / Full text

FNTA

The Hip Morphology Changes with Ageing in Asian Population. / 2018 / PubMed / Full text

FOSL1

RNA-Seq analysis reveals new evidence for inflammation-related changes in aged kidney. / 24.05.2016 / PubMed / Full text

FOSL2

LncRNA GUARDIN suppresses cellular senescence through a LRP130-PGC1α-FOXO4-p21-dependent signaling axis. / 03.04.2020 / PubMed / Full text

FOXD1

MicroRNA-338-5p plays a tumor suppressor role in glioma through inhibition of the MAPK-signaling pathway by binding to FOXD1. / 12.2018 / PubMed / Full text

FOXP2

Identification of the neurotransmitter profile of AmFoxP expressing neurons in the honeybee brain using double-label in situ hybridization. / 06.11.2018 / PubMed / Full text

FOXP4

Identification of the neurotransmitter profile of AmFoxP expressing neurons in the honeybee brain using double-label in situ hybridization. / 06.11.2018 / PubMed / Full text

FRAS1

FRAS1-related extracellular matrix 3 (FREM3) single-nucleotide polymorphism effects on gene expression, amygdala reactivity and perceptual processing speed: An accelerated aging pathway of depression risk. / 2015 / PubMed / Full text

FREM3

FRAS1-related extracellular matrix 3 (FREM3) single-nucleotide polymorphism effects on gene expression, amygdala reactivity and perceptual processing speed: An accelerated aging pathway of depression risk. / 2015 / PubMed / Full text

FRG1

Intergenerational response of steroidogenesis-related genes to maternal malnutrition. / 10.2019 / PubMed / Full text

FRG2

Intergenerational response of steroidogenesis-related genes to maternal malnutrition. / 10.2019 / PubMed / Full text

FSTL1

Blocking the FSTL1-DIP2A Axis Improves Anti-tumor Immunity. / 14.08.2018 / PubMed / Full text

FSTL5

Genome-Wide Association Analysis of the Sense of Smell in U.S. Older Adults: Identification of Novel Risk Loci in African-Americans and European-Americans. / 12.2017 / PubMed / Full text

FZD1

Frizzled-1 receptor regulates adult hippocampal neurogenesis. / 15.03.2016 / PubMed / Full text

FZD4

MiR-1292 Targets FZD4 to Regulate Senescence and Osteogenic Differentiation of Stem Cells in TE/SJ/Mesenchymal Tissue System via the Wnt/β-catenin Pathway. / 12.2018 / PubMed / Full text

G0S2

Investigating the specific core genetic-and-epigenetic networks of cellular mechanisms involved in human aging in peripheral blood mononuclear cells. / 23.02.2016 / PubMed / Full text

G3BP1

Dissecting the molecular mechanisms that impair stress granule formation in aging cells. / 03.2017 / PubMed / Full text

G6PC

Detection of a novel, primate-specific 'kill switch' tumor suppression mechanism that may fundamentally control cancer risk in humans: an unexpected twist in the basic biology of TP53. / 11.2018 / PubMed / Full text

G6PC2

Genome-wide association study identifies common loci influencing circulating glycated hemoglobin (HbA1c) levels in non-diabetic subjects: the Long Life Family Study (LLFS). / 04.2014 / PubMed / Full text

G6PC3

Both Granulocytic and Non-Granulocytic Blood Cells Are Affected in Patients with Severe Congenital Neutropenia and Their Non-Neutropenic Family Members: An Evaluation of Morphology, Function, and Cell Death / 13.11.2018 / PubMed / Full text

GAB2

Age-related gene expression changes, and transcriptome wide association study of physical and cognitive aging traits, in the Lothian Birth Cohort 1936. / 01.12.2017 / PubMed / Full text

GABARAP

Age-dependent loss of adipose Rubicon promotes metabolic disorders via excess autophagy. / 18.08.2020 / PubMed / Full text

GADD45B

Are There Common Mechanisms Between the Hutchinson-Gilford Progeria Syndrome and Natural Aging? / 2019 / PubMed / Full text

GADD45G

SIP1 is a downstream effector of GADD45G in senescence induction and growth inhibition of liver tumor cells. / 20.10.2015 / PubMed / Full text

GADD45GIP1

Nucleus accumbens-1/GADD45GIP1 axis mediates cisplatin resistance through cellular senescence in ovarian cancer. / 06.2017 / PubMed / Full text

GAK

Auxilin Underlies Progressive Locomotor Deficits and Dopaminergic Neuron Loss in a Drosophila Model of Parkinson's Disease. / 31.01.2017 / PubMed / Full text

GALNT3

N-ethyl-N-Nitrosourea (ENU) induced mutations within the klotho gene lead to ectopic calcification and reduced lifespan in mouse models. / 2015 / PubMed / Full text

GART

Maintaining the continuity of HIV-care records for patients transferring care between centers: challenges, workloads, needs and risks. / 08.2016 / PubMed / Full text

GAS2

Truncated HBx-dependent silencing of GAS2 promotes hepatocarcinogenesis through deregulation of cell cycle, senescence and p53-mediated apoptosis. / 09.2015 / PubMed / Full text

GAST

The effects of age and muscle contraction on AMPK activity and heterotrimer composition. / 07.2014 / PubMed / Full text

GATA1

Aging negatively impacts the ability of megakaryocytes to stimulate osteoblast proliferation and bone mass. / 10.2019 / PubMed / Full text

GBF1

Phosphorylation Affects DNA-Binding of the Senescence-Regulating bZIP Transcription Factor GBF1. / 16.09.2015 / PubMed / Full text

GCGR

Population pharmacokinetics and pharmacodynamics of IONIS-GCGR , an antisense oligonucleotide for type 2 diabetes mellitus: a red blood cell lifespan model. / 06.2017 / PubMed / Full text

GCH1

Aging modifies the effect of GCH1 RS11158026 on DAT uptake and Parkinson's disease clinical severity. / 02.2017 / PubMed / Full text

GCNA

Acceleration of age-associated methylation patterns in HIV-1-infected adults. / 2015 / PubMed / Full text

GCNT2

Human iPSC-derived MSCs (iMSCs) from aged individuals acquire a rejuvenation signature. / 18.03.2019 / PubMed / Full text

GDA

Comparison of the Shear Bond Strength of Metal Orthodontic Brackets Bonded to Long-term Water-aged and Fresh Porcelain and Composite Surfaces. / 03.2019 / PubMed / Full text

GDF5

An embryonic CaVβ1 isoform promotes muscle mass maintenance via GDF5 signaling in adult mouse. / 06.11.2019 / PubMed / Full text

GEN1

US acculturation and poor sleep among an intergenerational cohort of adult Latinos in Sacramento, California. / 01.03.2019 / PubMed / Full text

GFRA1

Determination phase at transition of gonocytes to spermatogonial stem cells improves establishment efficiency of spermatogonial stem cells in domestic cats. / 2015 / PubMed / Full text

GFRAL

Growth differentiation factor 15 (GDF15): A survival protein with therapeutic potential in metabolic diseases. / 06.2019 / PubMed / Full text

GGA3

The pathological roles of NDRG2 in Alzheimer's disease, a study using animal models and APPwt-overexpressed cells. / 08.2017 / PubMed / Full text

GGCX

Multiple Modes of Vitamin K Actions in Aging-Related Musculoskeletal Disorders. / 11.06.2019 / PubMed / Full text

GGT1

Relation of size of seminal vesicles on ultrasound to premature ejaculation. / 09-10.2017 / PubMed / Full text

GIGYF1

Drosophila Gyf/GRB10 interacting GYF protein is an autophagy regulator that controls neuron and muscle homeostasis. / 2015 / PubMed / Full text

GIGYF2

Drosophila Gyf/GRB10 interacting GYF protein is an autophagy regulator that controls neuron and muscle homeostasis. / 2015 / PubMed / Full text

GJA3

Down-regulation of GJA3 is associated with lens epithelial cell apoptosis and age-related cataract. / 26.02.2017 / PubMed / Full text

GJA8

The impact of GJA8 SNPs on susceptibility to age-related cataract. / 12.2018 / PubMed / Full text

GJB2

Reduced expression of Connexin26 and its DNA promoter hypermethylation in the inner ear of mimetic aging rats induced by d-galactose. / 26.09.2014 / PubMed / Full text

GJC2

Zebrafish brain RNA sequencing reveals that cell adhesion molecules are critical in brain aging. / 10.2020 / PubMed / Full text

GLP1R

A nutrigenomics approach for the study of anti-aging interventions: olive oil phenols and the modulation of gene and microRNA expression profiles in mouse brain. / 03.2017 / PubMed / Full text

GLRA1

Age-associated changes in DNA methylation across multiple tissues in an inbred mouse model. / 03.2016 / PubMed / Full text

GLRA2

Gene Expression Switching of Receptor Subunits in Human Brain Development. / 12.2015 / PubMed / Full text

GLRA3

Gene Expression Switching of Receptor Subunits in Human Brain Development. / 12.2015 / PubMed / Full text

GMDS

Validity and clinical utilization of the Chinese version of the Gotland Male Depression Scale at a men's health polyclinic. / 2014 / PubMed / Full text

GML

Age independently affects myelin integrity as detected by magnetization transfer magnetic resonance imaging in multiple sclerosis. / 2014 / PubMed / Full text

GNA14

Genetic correlation and genome-wide association study (GWAS) of the length of productive life, days open, and 305-days milk yield in crossbred Holstein dairy cattle. / 29.06.2017 / PubMed / Full text

GNAQ

GNAQ expression initiated in multipotent neural crest cells drives aggressive melanoma of the central nervous system. / 01.2020 / PubMed / Full text

GNG11

GNG11 (G-protein subunit γ 11) suppresses cell growth with induction of reactive oxygen species and abnormal nuclear morphology in human SUSM-1 cells. / 08.2017 / PubMed / Full text

GNG4

Neurotransmitter Pathway Genes in Cognitive Decline During Aging: Evidence for GNG4 and KCNQ2 Genes. / 05.2018 / PubMed / Full text

GNPAT

Plasmalogens Inhibit Endocytosis of Toll-like Receptor 4 to Attenuate the Inflammatory Signal in Microglial Cells. / 05.2019 / PubMed / Full text

GNRH2

Effects of Age and Estradiol on Gene Expression in the Rhesus Macaque Hypothalamus. / 2015 / PubMed / Full text

GORAB

Examining tissue composition, whole-bone morphology and mechanical behavior of Gorab mice tibiae: A mouse model of premature aging. / 08.12.2017 / PubMed / Full text

GOT1

Low expression of aging-related [[NRXN3]] is associated with Alzheimer disease: A systematic review and meta-analysis. / 07.2018 / PubMed / Full text

GP1BA

Novel molecular mechanisms for the adaptogenic effects of herbal extracts on isolated brain cells using systems biology. / 15.11.2018 / PubMed / Full text

GP2

Estimation of human age using N-glycan profiles from bloodstains. / 09.2015 / PubMed / Full text

GPBAR1

Activation of the bile acid receptor GPBAR1 (TGR5) ameliorates interleukin-1β (IL-1β)- induced chondrocytes senescence. / 10.2018 / PubMed / Full text

GPC1

Decreased expression of GPC1 in human skin keratinocytes and epidermis during ageing. / 15.10.2019 / PubMed / Full text

GPD1

The phenotype of a knockout mouse identifies flavin-containing monooxygenase 5 (FMO5) as a regulator of metabolic ageing. / 01.08.2015 / PubMed / Full text

GPD2

Switching off IMMP2L signaling drives senescence via simultaneous metabolic alteration and blockage of cell death. / 06.2018 / PubMed / Full text

GPR1

The Arabidopsis GPR1 Gene Negatively Affects Pollen Germination, Pollen Tube Growth, and Gametophyte Senescence. / 21.06.2017 / PubMed / Full text

GPR101

Regulation of Gonadotropin-Releasing Hormone-(1-5) Signaling Genes by Estradiol Is Age Dependent. / 2017 / PubMed / Full text

GPR158

RbAp48 Protein Is a Critical Component of GPR158/OCN Signaling and Ameliorates Age-Related Memory Loss. / 23.10.2018 / PubMed / Full text

GPR173

Regulation of Gonadotropin-Releasing Hormone-(1-5) Signaling Genes by Estradiol Is Age Dependent. / 2017 / PubMed / Full text

GPR19

Novel molecular mechanisms for the adaptogenic effects of herbal extracts on isolated brain cells using systems biology. / 15.11.2018 / PubMed / Full text

GPR37

Prosaposin and its receptors are differentially expressed in the salivary glands of male and female rats. / 08.2018 / PubMed / Full text

GPR37L1

Prosaposin and its receptors are differentially expressed in the salivary glands of male and female rats. / 08.2018 / PubMed / Full text

GPR6

Accelerated Epigenetic Aging and Methylation Disruptions Occur in Human Immunodeficiency Virus Infection Prior to Antiretroviral Therapy. / 22.09.2020 / PubMed / Full text

GPRC5C

Anti-diabetic action of all-trans retinoic acid and the orphan G protein coupled receptor GPRC5C in pancreatic β-cells. / 31.03.2017 / PubMed / Full text

GPX3

Long noncoding RNA glutathione peroxidase 3-antisense inhibits lens epithelial cell apoptosis by upregulating glutathione peroxidase 3 expression in age-related cataract. / 2019 / PubMed / Full text

GPX7

Metformin alleviates human cellular aging by upregulating the endoplasmic reticulum glutathione peroxidase 7. / 08.2018 / PubMed / Full text

GRAP

ASSOCIATION OF PREVASCULAR VITREOUS FISSURES AND CISTERNS WITH VITREOUS DEGENERATION AS ASSESSED BY SWEPT SOURCE OPTICAL COHERENCE TOMOGRAPHY. / 09.2015 / PubMed / Full text

GREM1

GREM1 inhibits osteogenic differentiation, senescence and BMP transcription of adipose-derived stem cells. / 09.03.2020 / PubMed / Full text

GREM2

Increase of gremlin 2 with age in human adipose-derived stromal/stem cells and its inhibitory effect on adipogenesis. / 12.2019 / PubMed / Full text

GRIA1

Hippocampal proteomics defines pathways associated with memory decline and resilience in normal aging and Alzheimer's disease mouse models. / 30.03.2017 / PubMed / Full text

GRID1

Gene discovery for high-density lipoprotein cholesterol level change over time in prospective family studies. / 03.2020 / PubMed / Full text

GRIN2A

Gene Expression Switching of Receptor Subunits in Human Brain Development. / 12.2015 / PubMed / Full text

GRINA

Genome-wide association study for lactation persistency, female fertility, longevity, and lifetime profit index traits in Holstein dairy cattle. / 02.2017 / PubMed / Full text

GRK4

G protein-coupled receptor kinase 4-induced cellular senescence and its senescence-associated gene expression profiling. / 15.11.2017 / PubMed / Full text

GRK6

Age-dependent effects of dopamine receptor inactivation on cocaine-induced behaviors in male rats: Evidence of dorsal striatal D2 receptor supersensitivity. / 12.2019 / PubMed / Full text

GRM2

Chronological age prediction based on DNA methylation: Massive parallel sequencing and random forest regression. / 11.2017 / PubMed / Full text

GRM6

Amyloid Precursor-Like Protein 2 deletion-induced retinal synaptopathy related to congenital stationary night blindness: structural, functional and molecular characteristics. / 08.06.2016 / PubMed / Full text

GRP

The loss of glucose-regulated protein 78 (GRP78) during normal aging or from siRNA knockdown augments human alpha-synuclein (α-syn) toxicity to rat nigral neurons. / 06.2015 / PubMed / Full text

GRPR

Gastrin-Releasing Peptide Receptor Knockdown Induces Senescence in Glioblastoma Cells. / 03.2017 / PubMed / Full text

GSN

Oral administration of alcalase potato protein hydrolysate-APPH attenuates high fat diet-induced cardiac complications via TGF-β/GSN axis in aging rats. / 01.2019 / PubMed / Full text

GSR

Meeting the Need for Training in Geriatrics: The Geriatrics Education for Specialty Residents Program. / 10.2017 / PubMed / Full text

GSTA3

Effects of insulin-like growth factor 1 on glutathione S-transferases and thioredoxin in growth hormone receptor knockout mice. / 2014 / PubMed / Full text

GSTK1

Age-associated changes in GSH S-transferase gene/proteins in livers of rats. / 12.2018 / PubMed / Full text

GSTM2

Small Extracellular Vesicles Have GST Activity and Ameliorate Senescence-Related Tissue Damage. / 07.07.2020 / PubMed / Full text

GSTO1

Age-associated changes in GSH S-transferase gene/proteins in livers of rats. / 12.2018 / PubMed / Full text

GSTT2

Age-associated changes in GSH S-transferase gene/proteins in livers of rats. / 12.2018 / PubMed / Full text

GTSF1

Postovulatory aging affects dynamics of mRNA, expression and localization of maternal effect proteins, spindle integrity and pericentromeric proteins in mouse oocytes. / 01.2016 / PubMed / Full text

GUK1

Characterization of the impact of GMP/GDP synthesis inhibition on replicative lifespan extension in yeast. / 08.2020 / PubMed / Full text

GYS2

In ovo feeding of creatine pyruvate modulates growth performance, energy reserves and mRNA expression levels of gluconeogenesis and glycogenesis enzymes in liver of embryos and neonatal broilers. / 04.2018 / PubMed / Full text

GZMH

Age-related profiling of DNA methylation in CD8 T cells reveals changes in immune response and transcriptional regulator genes. / 19.08.2015 / PubMed / Full text

GZMK

Comprehensive Profiling of an Aging Immune System Reveals Clonal GZMK CD8 T Cells as Conserved Hallmark of Inflammaging. / 21.11.2020 / PubMed / Full text

HABP4

Microneedle fractional radiofrequency increases epidermal hyaluronan and reverses age-related epidermal dysfunction. / 02.2016 / PubMed / Full text

HACE1

HACE1 reduces oxidative stress and mutant Huntingtin toxicity by promoting the NRF2 response. / 25.02.2014 / PubMed / Full text

HADH

Effect of testosterone on markers of mitochondrial oxidative phosphorylation and lipid metabolism in muscle of aging men with subnormal bioavailable testosterone. / 07.2014 / PubMed / Full text

HADHA

Exosomes from hyperglycemia-stimulated vascular endothelial cells contain versican that regulate calcification/senescence in vascular smooth muscle cells. / 2019 / PubMed / Full text

HAP1

The longevity SNP rs2802292 uncovered: HSF1 activates stress-dependent expression of FOXO3 through an intronic enhancer. / 20.06.2018 / PubMed / Full text

HAS3

Microneedle fractional radiofrequency increases epidermal hyaluronan and reverses age-related epidermal dysfunction. / 02.2016 / PubMed / Full text

HAX1

Both Granulocytic and Non-Granulocytic Blood Cells Are Affected in Patients with Severe Congenital Neutropenia and Their Non-Neutropenic Family Members: An Evaluation of Morphology, Function, and Cell Death / 13.11.2018 / PubMed / Full text

HBM

The effects of dietary fatty acids on bone, hematopoietic marrow and marrow adipose tissue in a murine model of senile osteoporosis. / 25.09.2019 / PubMed / Full text

HBZ

HTLV-1 Infection and Adult T-Cell Leukemia/Lymphoma-A Tale of Two Proteins: Tax and HBZ. / 16.06.2016 / PubMed / Full text

HCRT

Age-related central regulation of orexin and NPY in the short-lived African killifish Nothobranchius furzeri. / 15.05.2019 / PubMed / Full text

HDAC10

Middle-aged female rats lack changes in histone H3 acetylation in the anterior hypothalamus observed in young females on the day of a luteinizing hormone surge. / 17.09.2019 / PubMed / Full text

HDAC11

Disruption to schizophrenia-associated gene Fez1 in the hippocampus of HDAC11 knockout mice. / 19.09.2017 / PubMed / Full text

HDAC8

Histone deacetylase 1 expression is inversely correlated with age in the short-lived fish Nothobranchius furzeri. / 09.2018 / PubMed / Full text

HDAC9

MicroRNA-188 regulates age-related switch between osteoblast and adipocyte differentiation. / 04.2015 / PubMed / Full text

HDC

Induced pluripotency and spontaneous reversal of cellular aging in supercentenarian donor cells. / 07.05.2020 / PubMed / Full text

HDX

Pathways of aging: comparative analysis of gene signatures in replicative senescence and stress induced premature senescence. / 28.12.2016 / PubMed / Full text

HELLS

The Ubiquitin-like with PHD and Ring Finger Domains 1 (UHRF1)/DNA Methyltransferase 1 (DNMT1) Axis Is a Primary Regulator of Cell Senescence. / 03.03.2017 / PubMed / Full text

HEPN1

Functional analysis and transcriptional output of the Göttingen minipig genome. / 14.11.2015 / PubMed / Full text

HERC2

Endothelial SIRT1 prevents adverse arterial remodeling by facilitating HERC2-mediated degradation of acetylated LKB1. / 28.06.2016 / PubMed / Full text

HGSNAT

Progressive neurologic and somatic disease in a novel mouse model of human mucopolysaccharidosis type IIIC. / 01.09.2016 / PubMed / Full text

HHIP

Hhip haploinsufficiency sensitizes mice to age-related emphysema. / 09.08.2016 / PubMed / Full text

HHLA2

Impaired Cytolytic Activity and Loss of Clonal Neoantigens in Elderly Patients With Lung Adenocarcinoma. / 05.2019 / PubMed / Full text

HIF3A

Hypoxia-inducible transcription factors, HIF1A and HIF2A, increase in aging mucosal tissues. / 07.2018 / PubMed / Full text

HIP1

Extended Multiplexing of Tandem Mass Tags (TMT) Labeling Reveals Age and High Fat Diet Specific Proteome Changes in Mouse Epididymal Adipose Tissue. / 05.2017 / PubMed / Full text

HIPK2

Nore1a drives Ras to flick the P53 senescence switch. / 05.2016 / PubMed / Full text

HJV

Hemojuvelin is a novel suppressor for Duchenne muscular dystrophy and age-related muscle wasting. / 06.2019 / PubMed / Full text

HK1

Genome-wide association study identifies common loci influencing circulating glycated hemoglobin (HbA1c) levels in non-diabetic subjects: the Long Life Family Study (LLFS). / 04.2014 / PubMed / Full text

HLA-DMA

Epigenome-wide exploratory study of monozygotic twins suggests differentially methylated regions to associate with hand grip strength. / 10.2019 / PubMed / Full text

HLA-DPA1

17th IHIW component "Immunogenetics of Ageing" - New NGS data. / 09.2019 / PubMed / Full text

HLA-DRA

Frontotemporal dementia: insights into the biological underpinnings of disease through gene co-expression network analysis. / 24.02.2016 / PubMed / Full text

HLA-DRB4

Association and interaction effects of Alzheimer's disease-associated genes and lifestyle on cognitive aging in older adults in a Taiwanese population. / 11.04.2017 / PubMed / Full text

HLA-DRB5

Late Onset Alzheimer's Disease Risk Variants in Cognitive Decline: The PATH Through Life Study. / 2017 / PubMed / Full text

HLA-E

Senescent cells evade immune clearance via HLA-E-mediated NK and CD8 T cell inhibition. / 03.06.2019 / PubMed / Full text

HLA-F

Extended lifespan and reduced adiposity in mice lacking the FAT10 gene. / 08.04.2014 / PubMed / Full text

HLF

Healthy lifestyle and normal waist circumference are associated with a lower 5-year risk of type 2 diabetes in middle-aged and elderly individuals: Results from the healthy aging longitudinal study in Taiwan (HALST). / 02.2017 / PubMed / Full text

HMGA1

Characterization of [i]HMGA1P6[/i] transgenic mouse embryonic fibroblasts. / 09.2020 / PubMed / Full text

HMGCS2

The aged testis. A good model to find proteins involved in age-related changes of testis by proteomic analysis. / 01-02.2014 / PubMed

HMMR

The Naked Mole Rat Genome Resource: facilitating analyses of cancer and longevity-related adaptations. / 15.12.2014 / PubMed / Full text

HMX1

Pathways of aging: comparative analysis of gene signatures in replicative senescence and stress induced premature senescence. / 28.12.2016 / PubMed / Full text

HNF4A

Hepatocyte Nuclear Factor-4α P2 Promoter Variants Are Associated With the Risk of Metabolic Syndrome and Testosterone Deficiency in Aging Taiwanese Men. / 11.2018 / PubMed / Full text

HNRNPA0

The transcript expression levels of HNRNPM, HNRNPA0 and AKAP17A splicing factors may be predictively associated with ageing phenotypes in human peripheral blood. / 10.2019 / PubMed / Full text

HNRNPA2B1

Changes in the expression of splicing factor transcripts and variations in alternative splicing are associated with lifespan in mice and humans. / 10.2016 / PubMed / Full text

HNRNPF

Genome wide association and linkage analyses identified three loci-4q25, 17q23.2, and 10q11.21-associated with variation in leukocyte telomere length: the Long Life Family Study. / 2013 / PubMed / Full text

HNRNPM

The transcript expression levels of HNRNPM, HNRNPA0 and AKAP17A splicing factors may be predictively associated with ageing phenotypes in human peripheral blood. / 10.2019 / PubMed / Full text

HOXA3

DNA methylation analysis on purified neurons and glia dissects age and Alzheimer's disease-specific changes in the human cortex. / 25.07.2018 / PubMed / Full text

HOXA4

Epigenetic signatures of Werner syndrome occur early in life and are distinct from normal epigenetic aging processes. / 10.2019 / PubMed / Full text

HOXA5

HOXA5 localization in postnatal and adult mouse brain is suggestive of regulatory roles in postmitotic neurons. / 01.04.2017 / PubMed / Full text

HOXB7

Impact of HOXB7 overexpression on human adipose-derived mesenchymal progenitors. / 19.03.2019 / PubMed / Full text

HOXC13

Pathways of aging: comparative analysis of gene signatures in replicative senescence and stress induced premature senescence. / 28.12.2016 / PubMed / Full text

HOXD8

Single-Cell Transcriptome Analysis Reveals Six Subpopulations Reflecting Distinct Cellular Fates in Senescent Mouse Embryonic Fibroblasts. / 2020 / PubMed / Full text

HP1BP3

Systems genetics identifies Hp1bp3 as a novel modulator of cognitive aging. / 10.2016 / PubMed / Full text

HPDL

Characterization and cytological effects of a novel glycated gelatine substrate. / 04.2014 / PubMed / Full text

HPR

Sod1 gene ablation in adult mice leads to physiological changes at the neuromuscular junction similar to changes that occur in old wild-type mice. / 07.2015 / PubMed / Full text

HPSE

Distribution of heparan sulfate correlated with the expression of heparanase-1 and matrix metalloproteinase-9 in an ovariectomized rats skin. / 07.2020 / PubMed / Full text

HRC

Differences in false recollection according to the cognitive reserve of healthy older people. / 09.2016 / PubMed / Full text

HRH4

Histamime Receptor H4 as a New Therapeutic Target for Age-related Macular Degeneration. / 11.2016 / PubMed

HRK

Gene expression of key regulators of mitochondrial biogenesis is sex dependent in mice with growth hormone receptor deletion in liver. / 03.2015 / PubMed / Full text

HS2ST1

Whole Genome Analysis of the Red-Crowned Crane Provides Insight into Avian Longevity. / 31.01.2020 / PubMed / Full text

HSD17B1

Genetic Basis of the Relationship Between Reproduction and Longevity: A Study on Common Variants of Three Genes in Steroid Hormone Metabolism--CYP17, HSD17B1, and COMT. / 10.2015 / PubMed / Full text

HSD17B14

Bisphenol A induces DSB-ATM-p53 signaling leading to cell cycle arrest, senescence, autophagy, stress response, and estrogen release in human fetal lung fibroblasts. / 04.2018 / PubMed / Full text

HSD17B4

Autonomous Purkinje cell axonal dystrophy causes ataxia in peroxisomal multifunctional protein-2 deficiency. / 09.2018 / PubMed / Full text

HSF4

Effect of HSF4b on age related cataract may through its novel downstream target Hif1α. / 24.10.2014 / PubMed / Full text

HSPA13

Genetic associations with age of menopause in familial longevity. / 10.2019 / PubMed / Full text

HSPA1L

Melatonin suppresses senescence-derived mitochondrial dysfunction in mesenchymal stem cells via the HSPA1L-mitophagy pathway. / 03.2020 / PubMed / Full text

HSPA5

Expression of lipogenic markers is decreased in subcutaneous adipose tissue and adipocytes of older women and is negatively linked to GDF15 expression. / 08.2019 / PubMed / Full text

HSPBP1

BAG2 Interferes with CHIP-Mediated Ubiquitination of HSP72. / 30.12.2016 / PubMed / Full text

HSPG2

Proteomic profiling of follicle fluids after superstimulation in one-month-old lambs. / 02.2018 / PubMed / Full text

HTR1A

Gene Expression Switching of Receptor Subunits in Human Brain Development. / 12.2015 / PubMed / Full text

HTR2A

Region-specific regulation of the serotonin 2A receptor expression in development and ageing in post mortem human brain. / 06.2015 / PubMed / Full text

HTR2B

Up-regulation of serotonin receptor 2B mRNA and protein in the peri-infarcted area of aged rats and stroke patients. / 05.04.2016 / PubMed / Full text

HTR4

ADAM19 and HTR4 variants and pulmonary function: Cohorts for Heart and Aging Research in Genomic Epidemiology (CHARGE) Consortium Targeted Sequencing Study. / 06.2014 / PubMed / Full text

HTR5A

Gene Expression Switching of Receptor Subunits in Human Brain Development. / 12.2015 / PubMed / Full text

HYOU1

Expression of lipogenic markers is decreased in subcutaneous adipose tissue and adipocytes of older women and is negatively linked to GDF15 expression. / 08.2019 / PubMed / Full text

IBSP

P4 medicine and osteoporosis: a systematic review. / 12.2016 / PubMed / Full text

ICAM5

A reverse genetics cell-based evaluation of genes linked to healthy human tissue age. / 01.2017 / PubMed / Full text

ICE1

ATBS1-INTERACTING FACTOR 2 negatively regulates dark- and brassinosteroid-induced leaf senescence through interactions with INDUCER OF CBF EXPRESSION 1. / 19.02.2020 / PubMed / Full text

ID2

Epigenome-wide exploratory study of monozygotic twins suggests differentially methylated regions to associate with hand grip strength. / 10.2019 / PubMed / Full text

IDO1

Advanced age negatively impacts survival in an experimental brain tumor model. / 06.09.2016 / PubMed / Full text

IFI27

Ultraviolet B irradiation-induced keratinocyte senescence and impaired development of 3D epidermal reconstruct. / 01.06.2021 / PubMed / Full text

IFIH1

Comparative analysis of microbial sensing molecules in mucosal tissues with aging. / 03.2018 / PubMed / Full text

IFITM1

Age-Associated Changes in the Respiratory Epithelial Response to Influenza Infection. / 10.11.2018 / PubMed / Full text

IFITM3

Small Extracellular Vesicles Are Key Regulators of Non-cell Autonomous Intercellular Communication in Senescence via the Interferon Protein IFITM3. / 25.06.2019 / PubMed / Full text

IFNAR2

Type I interferon receptors in goose: molecular cloning, structural identification, evolutionary analysis and age-related tissue expression profile. / 25.04.2015 / PubMed / Full text

IFNB1

Effects of aging in the expression of NOD-like receptors and inflammasome-related genes in oral mucosa. / 02.2016 / PubMed / Full text

IFNGR2

Lifespan of mice and primates correlates with immunoproteasome expression. / 05.2015 / PubMed / Full text

IFT122

Co-chaperone p23 regulates C. elegans Lifespan in Response to Temperature. / 04.2015 / PubMed / Full text

IFT140

The Role of IFT140 in Osteogenesis of Adult Mice Long Bone. / 08.2019 / PubMed / Full text

IGF2BP2

Gene transcripts associated with muscle strength: a CHARGE meta-analysis of 7,781 persons. / 01.2016 / PubMed / Full text

IGF2BP3

Avenanthramide A Induces Cellular Senescence via miR-129-3p/Pirh2/p53 Signaling Pathway To Suppress Colon Cancer Growth. / 01.05.2019 / PubMed / Full text

IGFBP6

Proteomic profiling of follicle fluids after superstimulation in one-month-old lambs. / 02.2018 / PubMed / Full text

IGHD

Growth Hormone Deficiency: Health and Longevity. / 01.04.2019 / PubMed / Full text

IGHG2

Human IgG2- and IgG4-expressing memory B cells display enhanced molecular and phenotypic signs of maturity and accumulate with age. / 10.2017 / PubMed / Full text

IGHM

Developmental expression of B cell molecules in equine lymphoid tissues. / 01.2017 / PubMed / Full text

IGLL5

Whole-genome sequencing reveals activation-induced cytidine deaminase signatures during indolent chronic lymphocytic leukaemia evolution. / 07.12.2015 / PubMed / Full text

IGSF1

Age-related gene and miRNA expression changes in airways of healthy individuals. / 06.03.2019 / PubMed / Full text

IKBKB

Therapeutic and preventive effects of exercise on cardiometabolic parameters in aging and obese rats. / 02.2019 / PubMed / Full text

IL10RA

Exome sequencing analysis reveals variants in primary immunodeficiency genes in patients with very early onset inflammatory bowel disease. / 11.2015 / PubMed / Full text

IL11

Myocardial Infarction Superimposed on Aging: MMP-9 Deletion Promotes M2 Macrophage Polarization. / 04.2016 / PubMed / Full text

IL13RA1

Genetic correlation and genome-wide association study (GWAS) of the length of productive life, days open, and 305-days milk yield in crossbred Holstein dairy cattle. / 29.06.2017 / PubMed / Full text

IL17C

Age-dependent changes in inflammation and extracellular matrix in bovine oviduct epithelial cells during the post-ovulatory phase. / 09.2016 / PubMed / Full text

IL17D

Genetic determinants of P wave duration and PR segment. / 08.2014 / PubMed / Full text

IL17RA

Chronic disruptions of circadian sleep regulation induce specific proinflammatory responses in the rat colon. / 2017 / PubMed / Full text

IL17RC

Overstimulation can create health problems due to increases in PI3K/Akt/GSK3 insensitivity and GSK3 activity. / 2014 / PubMed / Full text

IL18

Aging and the Inflammasomes. / 2018 / PubMed / Full text

IL18RAP

Age and pro-inflammatory gene polymorphisms influence adjacent segment disc degeneration more than fusion does in patients treated for chronic low back pain. / 01.2016 / PubMed / Full text

IL1RN

Transcriptomic and epigenetic analyses reveal a gender difference in aging-associated inflammation: the Vitality 90 study. / 08.2015 / PubMed / Full text

IL21

The expression of IL6 and 21 in crossbred calves upregulated by inactivated trivalent FMD vaccine. / 03.04.2014 / PubMed / Full text

IL22

Age-specific changes in the molecular phenotype of patients with moderate-to-severe atopic dermatitis. / 07.2019 / PubMed / Full text

IL2RA

Dynamic demethylation of the IL2RA promoter during in vitro CD4 T cell activation in association with IL2RA expression. / 2018 / PubMed / Full text

IL2RG

Generation of a Nonhuman Primate Model of Severe Combined Immunodeficiency Using Highly Efficient Genome Editing. / 07.07.2016 / PubMed / Full text

IL33

Interleukin33 deficiency causes tau abnormality and neurodegeneration with Alzheimer-like symptoms in aged mice. / 04.07.2017 / PubMed / Full text

IL36RN

Elderly-Onset Generalized Pustular Psoriasis without a Previous History of Psoriasis Vulgaris. / 05-08.2015 / PubMed / Full text

IL6ST

The senescent status of endothelial cells affects proliferation, inflammatory profile and SOX2 expression in bone marrow-derived mesenchymal stem cells. / 06.2019 / PubMed / Full text

IL9

Transcription factor networks in aged naïve CD4 T cells bias lineage differentiation. / 08.2019 / PubMed / Full text

IMMP2L

Switching off IMMP2L signaling drives senescence via simultaneous metabolic alteration and blockage of cell death. / 06.2018 / PubMed / Full text

IMPA1

Coordinated Expression of Phosphoinositide Metabolic Genes during Development and Aging of Human Dorsolateral Prefrontal Cortex. / 2015 / PubMed / Full text

IMPA2

Coordinated Expression of Phosphoinositide Metabolic Genes during Development and Aging of Human Dorsolateral Prefrontal Cortex. / 2015 / PubMed / Full text

INA

XRCC1 and XPD genetic polymorphisms and susceptibility to age-related cataract: a meta-analysis. / 2015 / PubMed / Full text

INHBA

Proteomic profiling of follicle fluids after superstimulation in one-month-old lambs. / 02.2018 / PubMed / Full text

INHBE

Human iPSC-derived MSCs (iMSCs) from aged individuals acquire a rejuvenation signature. / 18.03.2019 / PubMed / Full text

INO80D

Whole exome sequencing implicates an INO80D mutation in a syndrome of aortic hypoplasia, premature atherosclerosis, and arterial stiffness. / 10.2014 / PubMed / Full text

INPP4B

[Target protein candidates of hypothalamus in aging rats with intervention by Qiongyugao]. / 04.2016 / PubMed / Full text

INPPL1

Coordinated Expression of Phosphoinositide Metabolic Genes during Development and Aging of Human Dorsolateral Prefrontal Cortex. / 2015 / PubMed / Full text

INSR

The Ubiquitin Ligase CHIP Integrates Proteostasis and Aging by Regulation of Insulin Receptor Turnover. / 20.04.2017 / PubMed / Full text

IP6K1

The Role of the IGF-1 Signaling Cascade in Muscle Protein Synthesis and Anabolic Resistance in Aging Skeletal Muscle. / 2019 / PubMed / Full text

IP6K3

Inositol Hexakisphosphate Kinase 3 Regulates Metabolism and Lifespan in Mice. / 31.08.2016 / PubMed / Full text

IPMK

Inositol Polyphosphate Multikinase ([i]IPMK[/i]), a Gene Coding for a Potential Moonlighting Protein, Contributes to Human Female Longevity. / 08.02.2019 / PubMed / Full text

IRAK4

The Expression Changes of Inflammasomes in the Aging Rat Kidneys. / 06.2016 / PubMed / Full text

IRF1

Sirtuin 1-Chromatin-Binding Dynamics Points to a Common Mechanism Regulating Inflammatory Targets in SIV Infection and in the Aging Brain. / 06.2018 / PubMed / Full text

IRF5

Age-related differences in interferon regulatory factor-4 and -5 signaling in ischemic brains of mice. / 11.2017 / PubMed / Full text

IRX2

Pathways of aging: comparative analysis of gene signatures in replicative senescence and stress induced premature senescence. / 28.12.2016 / PubMed / Full text

ISG15

Transcriptome analysis reveals immune-related gene expression changes with age in giant panda ([i]Ailuropoda melanoleuca[/i]) blood. / 14.01.2019 / PubMed / Full text

ISG20

A Large Genome-Wide Association Study of Age-Related Hearing Impairment Using Electronic Health Records. / 10.2016 / PubMed / Full text

ISL1

Deterioration of the Medial Olivocochlear Efferent System Accelerates Age-Related Hearing Loss in Pax2-Isl1 Transgenic Mice. / 05.2016 / PubMed / Full text

ISYNA1

Coordinated Expression of Phosphoinositide Metabolic Genes during Development and Aging of Human Dorsolateral Prefrontal Cortex. / 2015 / PubMed / Full text

ITCH

Selective multifaceted E3 ubiquitin ligases barricade extreme defense: Potential therapeutic targets for neurodegeneration and ageing. / 11.2015 / PubMed / Full text

ITGA2

[Clinical and genetic characteristics of long-livers in Moscow region]. / 2013 / PubMed

ITGA3

A transcriptomic analysis of serial-cultured, tonsil-derived mesenchymal stem cells reveals decreased integrin α3 protein as a potential biomarker of senescent cells. / 17.08.2020 / PubMed / Full text

ITGA5

Kaempferol alleviates the reduction of developmental competence during aging of porcine oocytes. / 11.2019 / PubMed / Full text

ITGA6

Selective molecular biomarkers to predict biologic behavior in pituitary tumors. / 05.2017 / PubMed / Full text

ITGB1

Switch in Laminin β2 to Laminin β1 Isoforms During Aging Controls Endothelial Cell Functions-Brief Report. / 05.2018 / PubMed / Full text

ITGB2

A Microglial Signature Directing Human Aging and Neurodegeneration-Related Gene Networks. / 2019 / PubMed / Full text

ITGB4

ITGB4 deficiency induces senescence of airway epithelial cells through p53 activation. / 03.2019 / PubMed / Full text

ITGB5

Differential DNA Methylation in Relation to Age and Health Risks of Obesity. / 24.07.2015 / PubMed / Full text

ITM2B

Intramembrane proteolysis within lysosomes. / 12.2016 / PubMed / Full text

ITPKB

Coordinated Expression of Phosphoinositide Metabolic Genes during Development and Aging of Human Dorsolateral Prefrontal Cortex. / 2015 / PubMed / Full text

ITPR1

Age-associated repression of type 1 inositol 1, 4, 5-triphosphate receptor impairs muscle regeneration. / 21.09.2016 / PubMed / Full text

ITPR2

The nuclear receptor RXRA controls cellular senescence by regulating calcium signaling. / 12.2018 / PubMed / Full text

JAG1

Targeted sequencing of genome wide significant loci associated with bone mineral density (BMD) reveals significant novel and rare variants: the Cohorts for Heart and Aging Research in Genomic Epidemiology (CHARGE) targeted sequencing study. / 01.12.2016 / PubMed / Full text

JAGN1

Both Granulocytic and Non-Granulocytic Blood Cells Are Affected in Patients with Severe Congenital Neutropenia and Their Non-Neutropenic Family Members: An Evaluation of Morphology, Function, and Cell Death / 13.11.2018 / PubMed / Full text

JAM3

Selective molecular biomarkers to predict biologic behavior in pituitary tumors. / 05.2017 / PubMed / Full text

JARID2

Proteomics and metabolomics identify molecular mechanisms of aging potentially predisposing for chronic lymphocytic leukemia. / 02.2018 / PubMed / Full text

JDP2

Jun dimerization protein 2 controls hypoxia-induced replicative senescence via both the p16 -pRb and Arf-p53 pathways. / 11.2017 / PubMed / Full text

JUNB

Promotion of cellular senescence by THG-1/TSC22D4 knockout through activation of JUNB. / 19.02.2020 / PubMed / Full text

JUP

From comorbidities of chronic obstructive pulmonary disease to identification of shared molecular mechanisms by data integration. / 22.11.2016 / PubMed / Full text

KALRN

Age-dependent increase in Kalirin-9 and Kalirin-12 transcripts in human orbitofrontal cortex. / 10.2016 / PubMed / Full text

KANSL1

Koolen-de Vries Syndrome: Clinical Report of an Adult and Literature Review. / 2016 / PubMed / Full text

KAT6B

Aging-associated decrease in the histone acetyltransferase KAT6B is linked to altered hematopoietic stem cell differentiation. / 02.2020 / PubMed / Full text

KCNAB3

Tracking age-correlated DNA methylation markers in the young. / 09.2018 / PubMed / Full text

KCNC3

DNA methylation levels in candidate genes associated with chronological age in mammals are not conserved in a long-lived seabird. / 2017 / PubMed / Full text

KCNC4

Targeted deletion of [i]Kcne3[/i] impairs skeletal muscle function in mice. / 07.2017 / PubMed / Full text

KCND3

Genetic determinants of P wave duration and PR segment. / 08.2014 / PubMed / Full text

KCNE3

Targeted deletion of [i]Kcne3[/i] impairs skeletal muscle function in mice. / 07.2017 / PubMed / Full text

KCNE4

Kcne4 deletion sex-specifically predisposes to cardiac arrhythmia via testosterone-dependent impairment of RISK/SAFE pathway induction in aged mice. / 29.05.2018 / PubMed / Full text

KCNH2

Targeted deletion of [i]Kcne3[/i] impairs skeletal muscle function in mice. / 07.2017 / PubMed / Full text

KCNJ6

Genetic correlates of the development of theta event related oscillations in adolescents and young adults. / 05.2017 / PubMed / Full text

KCNK2

Brain age prediction using deep learning uncovers associated sequence variants. / 27.11.2019 / PubMed / Full text

KCNK4

Targeted deletion of [i]Kcne3[/i] impairs skeletal muscle function in mice. / 07.2017 / PubMed / Full text

KCNQ1

Exercise-associated DNA methylation change in skeletal muscle and the importance of imprinted genes: a bioinformatics meta-analysis. / 12.2015 / PubMed / Full text

KCNQ1DN

The EpiTect Methyl qPCR Assay as novel age estimation method in forensic biology. / 07.2016 / PubMed / Full text

KCNQ2

Neurotransmitter Pathway Genes in Cognitive Decline During Aging: Evidence for GNG4 and KCNQ2 Genes. / 05.2018 / PubMed / Full text

KCNQ4

Guanylyl Cyclase A/cGMP Signaling Slows Hidden, Age- and Acoustic Trauma-Induced Hearing Loss. / 2020 / PubMed / Full text

KCP

The kielin/chordin-like protein KCP attenuates nonalcoholic fatty liver disease in mice. / 01.10.2016 / PubMed / Full text

KCTD12

The association between poverty and gene expression within peripheral blood mononuclear cells in a diverse Baltimore City cohort. / 2020 / PubMed / Full text

KDF1

The histological characteristics, age-related thickness change of skin, and expression of the HSPs in the skin during hair cycle in yak (Bos grunniens). / 2017 / PubMed / Full text

KDM2A

SIRT6 mono-ADP ribosylates KDM2A to locally increase H3K36me2 at DNA damage sites to inhibit transcription and promote repair. / 25.06.2020 / PubMed / Full text

KDM4A

Structure-Based Discovery of a Selective KDM5A Inhibitor that Exhibits Anti-Cancer Activity via Inducing Cell Cycle Arrest and Senescence in Breast Cancer Cell Lines. / 15.01.2019 / PubMed / Full text

KDM4B

Hypoxia-Inducible Histone Lysine Demethylases: Impact on the Aging Process and Age-Related Diseases. / 03.2016 / PubMed / Full text

KDM4C

Hypoxia-Inducible Histone Lysine Demethylases: Impact on the Aging Process and Age-Related Diseases. / 03.2016 / PubMed / Full text

KDM5A

Structure-Based Discovery of a Selective KDM5A Inhibitor that Exhibits Anti-Cancer Activity via Inducing Cell Cycle Arrest and Senescence in Breast Cancer Cell Lines. / 15.01.2019 / PubMed / Full text

KDM5B

Hypoxia-Inducible Histone Lysine Demethylases: Impact on the Aging Process and Age-Related Diseases. / 03.2016 / PubMed / Full text

KDR

Regulation of endothelial progenitor cell differentiation and function by dimethylarginine dimethylaminohydrolase 2 in an asymmetric dimethylarginine-independent manner. / 09.2014 / PubMed / Full text

KIAA0319

The Dyslexia-susceptibility Protein KIAA0319 Inhibits Axon Growth Through Smad2 Signaling. / 01.03.2017 / PubMed / Full text

KIF11

Bmk-1 regulates lifespan in Caenorhabditis elegans by activating hsp-16. / 07.08.2015 / PubMed / Full text

KIF1A

SerThr-PhosphoProteome of Brain from Aged PINK1-KO A53T-SNCA Mice Reveals pT1928-MAP1B and pS3781-ANK2 Deficits, as Hub between Autophagy and Synapse Changes. / 04.07.2019 / PubMed / Full text

KIF3A

Progressive axonal transport and synaptic protein changes correlate with behavioral and neuropathological abnormalities in the heterozygous Q175 KI mouse model of Huntington's disease. / 01.09.2014 / PubMed / Full text

KIF5C

Alteration of Motor Protein Expression Involved in Bidirectional Transport in Peripheral Blood Mononuclear Cells of Patients with Amyotrophic Lateral Sclerosis. / 2016 / PubMed / Full text

KIF6

Gene variants at FTO, 9p21, and 2q36.3 are age-independently associated with myocardial infarction in Czech men. / 15.02.2016 / PubMed / Full text

KLB

Infants Uniquely Express High Levels of RBM3 and Other Cold-Adaptive Neuroprotectant Proteins in the Human Brain. / 2018 / PubMed / Full text

KLF1

Mutant KLF1 in Adult Anemic Nan Mice Leads to Profound Transcriptome Changes and Disordered Erythropoiesis. / 24.08.2018 / PubMed / Full text

KLF10

Polymorphism rs7278468 is associated with Age-related cataract through decreasing transcriptional activity of the CRYAA promoter. / 17.03.2016 / PubMed / Full text

KLF2

KLF2 induces the senescence of pancreatic cancer cells by cooperating with FOXO4 to upregulate p21. / 01.03.2020 / PubMed / Full text

KLF5

EGR1 promotes the cartilage degeneration and hypertrophy by activating the Krüppel-like factor 5 and β-catenin signaling. / 01.09.2019 / PubMed / Full text

KLF6

Krüppel-Like Factor 6 Is Required for Oxidative and Oncogene-Induced Cellular Senescence. / 2019 / PubMed / Full text

KLHL13

Genetic correlation and genome-wide association study (GWAS) of the length of productive life, days open, and 305-days milk yield in crossbred Holstein dairy cattle. / 29.06.2017 / PubMed / Full text

KLHL22

KLHL22 activates amino-acid-dependent mTORC1 signalling to promote tumorigenesis and ageing. / 05.2018 / PubMed / Full text

KPNA5

Global Characteristics of CSIG-Associated Gene Expression Changes in Human HEK293 Cells and the Implications for CSIG Regulating Cell Proliferation and Senescence. / 2015 / PubMed / Full text

KRR1

Causal mechanisms and balancing selection inferred from genetic associations with polycystic ovary syndrome. / 29.09.2015 / PubMed / Full text

KRT15

Extracellular proteoglycan decorin maintains human hair follicle stem cells. / 12.2018 / PubMed / Full text

KRT18

Towards frailty biomarkers: Candidates from genes and pathways regulated in aging and age-related diseases. / 11.2018 / PubMed / Full text

KRT19

Characterization of Krt19 allele for targeting the nucleus pulposus cells in the postnatal mouse intervertebral disc. / 01.2020 / PubMed / Full text

KRT5

Alternative Progenitor Lineages Regenerate the Adult Lung Depleted of Alveolar Epithelial Type 2 Cells. / 04.2017 / PubMed / Full text

KTN1

Common genetic variants influence human subcortical brain structures. / 09.04.2015 / PubMed / Full text

L3MBTL1

Exercise-associated DNA methylation change in skeletal muscle and the importance of imprinted genes: a bioinformatics meta-analysis. / 12.2015 / PubMed / Full text

LAGE3

Novel homozygous OSGEP gene pathogenic variants in two unrelated patients with Galloway-Mowat syndrome: case report and review of the literature. / 11.04.2019 / PubMed / Full text

LAMA1

Laminin α1 regulates age-related mesangial cell proliferation and mesangial matrix accumulation through the TGF-β pathway. / 06.2014 / PubMed / Full text

LAMA2

[Alu insertion-deletion polymorphism of COL13A1 and LAMA2 genes: The analysis of association with longevity]. / 10.2016 / PubMed

LATS1

Impaired liver regeneration in aged mice can be rescued by silencing Hippo core kinases MST1 and MST2. / 01.2017 / PubMed / Full text

LDB2

Chronological age prediction based on DNA methylation: Massive parallel sequencing and random forest regression. / 11.2017 / PubMed / Full text

LDHC

The aged testis. A good model to find proteins involved in age-related changes of testis by proteomic analysis. / 01-02.2014 / PubMed

LEF1

LncRNA H19 targets miR-22 to modulate H O -induced deregulation in nucleus pulposus cell senescence, proliferation, and ECM synthesis through Wnt signaling. / 06.2018 / PubMed / Full text

LGALS3

Tissue Taurine Depletion Induces Profibrotic Pattern of Gene Expression and Causes Aging-Related Cardiac Fibrosis in Heart in Mice. / 2018 / PubMed / Full text

LGI1

Antibody-associated CNS syndromes without signs of inflammation in the elderly. / 03.10.2017 / PubMed / Full text

LGR6

Effect of defensins-containing eye cream on periocular rhytids and skin quality. / 08.2020 / PubMed / Full text

LHB

'Carriers of variant luteinizing hormone (V-LH) among 1593 Baltic men have significantly higher serum LH'. / 05.2015 / PubMed / Full text

LHCGR

Comparative Study of the Steroidogenic Effects of Human Chorionic Gonadotropin and Thieno[2,3-D]pyrimidine-Based Allosteric Agonist of Luteinizing Hormone Receptor in Young Adult, Aging and Diabetic Male Rats. / 11.10.2020 / PubMed / Full text

LIMK2

Reduced corporal fibrosis to protect erectile function by inhibiting the Rho-kinase/LIM-kinase/cofilin pathway in the aged transgenic rat harboring human tissue kallikrein 1. / 01-02.2017 / PubMed / Full text

LIN28B

Genetic variations, reproductive aging, and breast cancer risk in African American and European American women: The Women's Circle of Health Study. / 2017 / PubMed / Full text

LINC00862

Genome-Wide Association Analysis of the Sense of Smell in U.S. Older Adults: Identification of Novel Risk Loci in African-Americans and European-Americans. / 12.2017 / PubMed / Full text

LIPA

Influence of Habitual Physical Behavior - Sleeping, Sedentarism, Physical Activity - On Bone Health in Community-Dwelling Older People. / 2019 / PubMed / Full text

LMNB2

Physiological and Pathological Aging Affects Chromatin Dynamics, Structure and Function at the Nuclear Edge. / 2016 / PubMed / Full text

LMO2

Aging-dependent DNA hypermethylation and gene expression of GSTM1 involved in T cell differentiation. / 25.07.2017 / PubMed / Full text

LMX1A

Phenotypic Reprogramming of Striatal Neurons into Dopaminergic Neuron-like Cells in the Adult Mouse Brain. / 13.11.2018 / PubMed / Full text

LOXL4

Blood Vessel Basement Membrane Alterations in Human Retinal Microaneurysms During Aging. / 01.02.2017 / PubMed / Full text

LPAR3

Upregulated microRNA-15b alleviates ovarian cancer through inhitbition of the PI3K/Akt pathway by targeting LPAR3. / 12.2019 / PubMed / Full text

LRAT

Oxidative stress induces mitochondrial dysfunction and a protective unfolded protein response in RPE cells. / 04.2014 / PubMed / Full text

LRCH1

Genetic determinants of P wave duration and PR segment. / 08.2014 / PubMed / Full text

LRP2

Single-Cell Transcriptomics Characterizes Cell Types in the Subventricular Zone and Uncovers Molecular Defects Impairing Adult Neurogenesis. / 27.11.2018 / PubMed / Full text

LRP8

SFRS11 Loss Leads to Aging-Associated Cognitive Decline by Modulating LRP8 and ApoE. / 02.07.2019 / PubMed / Full text

LRRC34

The polygenic nature of telomere length and the anti-ageing properties of lithium. / 03.2019 / PubMed / Full text

LRRC8B

DNA methylation analysis on purified neurons and glia dissects age and Alzheimer's disease-specific changes in the human cortex. / 25.07.2018 / PubMed / Full text

LRRK1

Age-Dependent Dopaminergic Neurodegeneration and Impairment of the Autophagy-Lysosomal Pathway in LRRK-Deficient Mice. / 15.11.2017 / PubMed / Full text

LTBP4

Extended Multiplexing of Tandem Mass Tags (TMT) Labeling Reveals Age and High Fat Diet Specific Proteome Changes in Mouse Epididymal Adipose Tissue. / 05.2017 / PubMed / Full text

LY6D

LY6D-induced macropinocytosis as a survival mechanism of senescent cells. / 09.11.2020 / PubMed / Full text

LY86

Identification of age- and gender-associated long noncoding RNAs in the human brain with Alzheimer's disease. / 09.2019 / PubMed / Full text

LYG1

Uncovering genetic mechanisms of kidney aging through transcriptomics, genomics, and epigenomics. / 03.2019 / PubMed / Full text

LYST

Whole-Exome Sequencing of an Exceptional Longevity Cohort. / 16.08.2019 / PubMed / Full text

MADD

Association of levels of fasting glucose and insulin with rare variants at the chromosome 11p11.2-MADD locus: Cohorts for Heart and Aging Research in Genomic Epidemiology (CHARGE) Consortium Targeted Sequencing Study. / 06.2014 / PubMed / Full text

MAFB

Age-dependent skeletal muscle transcriptome response to bed rest-induced atrophy. / 01.04.2019 / PubMed / Full text

MAGOHB

Proteomic analysis reveals novel common genes modulated in both replicative and stress-induced senescence. / 14.10.2015 / PubMed / Full text

MANF

Age-dependent decrease in chaperone activity impairs MANF expression, leading to Purkinje cell degeneration in inducible SCA17 mice. / 22.01.2014 / PubMed / Full text

MAP2K3

Associations of [i]MAP2K3[/i] Gene Variants With Superior Memory in SuperAgers. / 2018 / PubMed / Full text

MAP3K11

Aberrant DNA Methylation in Keratoacanthoma. / 2016 / PubMed / Full text

MAP3K5

Analysis of Polymorphisms in 59 Potential Candidate Genes for Association With Human Longevity. / 08.10.2018 / PubMed / Full text

MAP4K3

MAP4K3/GLK in autoimmune disease, cancer and aging. / 22.10.2019 / PubMed / Full text

MAPK10

Novel molecular mechanisms for the adaptogenic effects of herbal extracts on isolated brain cells using systems biology. / 15.11.2018 / PubMed / Full text

MAPK11

lncRNA ENSMUST00000134285 Increases MAPK11 Activity, Regulating Aging-Related Myocardial Apoptosis. / 09.07.2018 / PubMed / Full text

MAPK13

Novel molecular mechanisms for the adaptogenic effects of herbal extracts on isolated brain cells using systems biology. / 15.11.2018 / PubMed / Full text

MAPK8

Therapeutic and preventive effects of exercise on cardiometabolic parameters in aging and obese rats. / 02.2019 / PubMed / Full text

MARCKSL1

MARCKSL1 Regulates Spine Formation in the Amygdala and Controls the Hypothalamic-Pituitary-Adrenal Axis and Anxiety-Like Behaviors. / 04.2018 / PubMed / Full text

MARK1

SerThr-PhosphoProteome of Brain from Aged PINK1-KO A53T-SNCA Mice Reveals pT1928-MAP1B and pS3781-ANK2 Deficits, as Hub between Autophagy and Synapse Changes. / 04.07.2019 / PubMed / Full text

MAS1

AVE0991, a nonpeptide analogue of Ang-(1-7), attenuates aging-related neuroinflammation. / 17.04.2018 / PubMed / Full text

MATN3

Mice Lacking the Matrilin Family of Extracellular Matrix Proteins Develop Mild Skeletal Abnormalities and Are Susceptible to Age-Associated Osteoarthritis. / 19.01.2020 / PubMed / Full text

MATR3

Heterogeneity of Matrin 3 in the developing and aging murine central nervous system. / 01.10.2016 / PubMed / Full text

MBD2

Age-related Changes in the Global DNA Methylation Profile of Oligodendrocyte Progenitor Cells Derived from Rat Spinal Cords. / 02.2019 / PubMed / Full text

MBL2

Recurrent respiratory tract infections (RRTI) in the elderly: A late onset mild immunodeficiency? / 07.2017 / PubMed / Full text

MC4R

Melanocortin-4 receptor rs17782313 polymorphisms are associated with serum triglycerides in older Chinese women. / 2016 / PubMed / Full text

MCF2L

DNA methylation analysis on purified neurons and glia dissects age and Alzheimer's disease-specific changes in the human cortex. / 25.07.2018 / PubMed / Full text

MCM4

Changes in MCM2-7 proteins at senescence. / 27.07.2019 / PubMed / Full text

MCM5

Changes in MCM2-7 proteins at senescence. / 27.07.2019 / PubMed / Full text

MCM6

Changes in MCM2-7 proteins at senescence. / 27.07.2019 / PubMed / Full text

MCUR1

Cytosolic and mitochondrial Ca concentrations in primary hepatocytes change with ageing and in consequence of an mtDNA mutation. / 09.2019 / PubMed / Full text

MDK

A large-scale CRISPR screen and identification of essential genes in cellular senescence bypass. / 20.06.2019 / PubMed / Full text

MDM4

Germline genetics of the p53 pathway affect longevity in a gender specific manner. / 2014 / PubMed / Full text

MDN1

Whole-Exome Sequencing of an Exceptional Longevity Cohort. / 16.08.2019 / PubMed / Full text

ME3

Acceleration of age-associated methylation patterns in HIV-1-infected adults. / 2015 / PubMed / Full text

MECOM

Clinical and genetic risk factors for decreased bone mineral density in Japanese patients with inflammatory bowel disease. / 11.2018 / PubMed / Full text

MED25

The [i]HAC1[/i] histone acetyltransferase promotes leaf senescence and regulates the expression of [i]ERF022[/i]. / 08.2019 / PubMed / Full text

MED28

Redox regulation of the MED28 and MED32 mediator subunits is important for development and senescence. / 05.2016 / PubMed / Full text

MEFV

The grandfather's fever. / 02.2020 / PubMed / Full text

MEIS2

Pbx1 is required for adult subventricular zone neurogenesis. / 01.07.2016 / PubMed / Full text

MELK

MELK-T1, a small-molecule inhibitor of protein kinase MELK, decreases DNA-damage tolerance in proliferating cancer cells. / 02.10.2015 / PubMed / Full text

MERTK

Novel molecular mechanisms for the adaptogenic effects of herbal extracts on isolated brain cells using systems biology. / 15.11.2018 / PubMed / Full text

MESP1

Simulated Microgravity Exerts an Age-Dependent Effect on the Differentiation of Cardiovascular Progenitors Isolated from the Human Heart. / 2015 / PubMed / Full text

MEST

Improving specific autobiographical memory in older adults: impacts on mood, social problem solving, and functional limitations. / 09.2018 / PubMed / Full text

MFAP4

The role of microfibrillar-associated protein 4 (MFAP4) in the formation and function of splenic compartments during embryonic and adult life. / 07.2016 / PubMed / Full text

MFSD2A

Decreased Blood Level of MFSD2a as a Potential Biomarker of Alzheimer's Disease. / 20.12.2019 / PubMed / Full text

MIB1

Immunohistochemical detection of senescence markers in human sarcomas. / 02.2020 / PubMed / Full text

MICB

Genetic associations with age of menopause in familial longevity. / 10.2019 / PubMed / Full text

MICU1

Cytosolic and mitochondrial Ca concentrations in primary hepatocytes change with ageing and in consequence of an mtDNA mutation. / 09.2019 / PubMed / Full text

MLH3

Age-Dependent Alterations in Meiotic Recombination Cause Chromosome Segregation Errors in Spermatocytes. / 19.10.2017 / PubMed / Full text

MLST8

Genetic variants near MLST8 and DHX57 affect the epigenetic age of the cerebellum. / 02.02.2016 / PubMed / Full text

MMP10

Bone biology-related gingival transcriptome in ageing and periodontitis in non-human primates. / 05.2016 / PubMed / Full text

MMP14

Overexpression of microRNA-1470 promotes proliferation and migration, and inhibits senescence of esophageal squamous carcinoma cells. / 12.2017 / PubMed / Full text

MMP8

Bone biology-related gingival transcriptome in ageing and periodontitis in non-human primates. / 05.2016 / PubMed / Full text

MOG

ASSOCIATION OF PREVASCULAR VITREOUS FISSURES AND CISTERNS WITH VITREOUS DEGENERATION AS ASSESSED BY SWEPT SOURCE OPTICAL COHERENCE TOMOGRAPHY. / 09.2015 / PubMed / Full text

MORF4L1

A large-scale CRISPR screen and identification of essential genes in cellular senescence bypass. / 20.06.2019 / PubMed / Full text

MPC1

Age-related impairments in skeletal muscle PDH phosphorylation and plasma lactate are indicative of metabolic inflexibility and the effects of exercise training. / 01.07.2016 / PubMed / Full text

MPG

Menoprogen, a TCM Herbal Formula for Menopause, Increases Endogenous E2 in an Aged Rat Model of Menopause by Reducing Ovarian Granulosa Cell Apoptosis. / 2016 / PubMed / Full text

MPHOSPH6

Genome-wide Association Analysis in Humans Links Nucleotide Metabolism to Leukocyte Telomere Length. / 05.03.2020 / PubMed / Full text

MPL

Molecular Pathogenesis of Myeloproliferative Neoplasms: Influence of Age and Gender. / 10.2017 / PubMed / Full text

MPP4

DNA damage tolerance in hematopoietic stem and progenitor cells in mice. / 15.08.2017 / PubMed / Full text

MPST

Methionine restriction leads to hyperhomocysteinemia and alters hepatic H S production capacity in Fischer-344 rats. / 12.2018 / PubMed / Full text

MPV17

The Human Mitochondrial DNA Depletion Syndrome Gene MPV17 Encodes a Non-selective Channel That Modulates Membrane Potential. / 29.05.2015 / PubMed / Full text

MRC1

Myocardial Infarction Superimposed on Aging: MMP-9 Deletion Promotes M2 Macrophage Polarization. / 04.2016 / PubMed / Full text

MRO

[Effects of different intensities exercise combined with resveratrol on RBP4 in aged obese rats]. / 08.05.2017 / PubMed / Full text

MRTFA

Endothelial progerin expression causes cardiovascular pathology through an impaired mechanoresponse. / 01.02.2019 / PubMed / Full text

MS4A1

Age-related but not longevity-related genes are found by weighted gene co-expression network analysis in the peripheral blood cells of humans. / 19.01.2019 / PubMed / Full text

MS4A4A

Association and interaction effects of Alzheimer's disease-associated genes and lifestyle on cognitive aging in older adults in a Taiwanese population. / 11.04.2017 / PubMed / Full text

MS4A6A

Recent studies on cellular and molecular mechanisms in Alzheimer's disease: focus on epigenetic factors and histone deacetylase. / 28.03.2018 / PubMed / Full text

MSH3

RNA-Seq analysis of differentially expressed genes relevant to mismatch repair in aging hematopoietic stem-progenitor cells. / 25.02.2019 / PubMed / Full text

MSH5

Exome sequencing analysis reveals variants in primary immunodeficiency genes in patients with very early onset inflammatory bowel disease. / 11.2015 / PubMed / Full text

MSH6

RNA-Seq analysis of differentially expressed genes relevant to mismatch repair in aging hematopoietic stem-progenitor cells. / 25.02.2019 / PubMed / Full text

MSN

The sigma-1 receptor mediates the beneficial effects of pridopidine in a mouse model of Huntington disease. / 01.2017 / PubMed / Full text

MSR1

Role of TGFβ signaling in the pathogenesis of Alzheimer's disease. / 2015 / PubMed / Full text

MSRA

Temporal pattern of neuronal insulin release during Caenorhabditis elegans aging: Role of redox homeostasis. / 02.2019 / PubMed / Full text

MT1B

Pharmacological advantages of melatonin in immunosenescence by improving activity of T lymphocytes. / 07.2016 / PubMed / Full text

MT1M

A novel strain of Lactobacillus mucosae isolated from a Gaotian villager improves in vitro and in vivo antioxidant as well as biological properties in D-galactose-induced aging mice. / 02.2016 / PubMed / Full text

MT3

Age-related changes of metallothionein 1/2 and metallothionein 3 expression in rat brain. / 01.2017 / PubMed / Full text

MTBP

Multiomics Approach to Novel Therapeutic Targets for Cancer and Aging-Related Diseases: Role of Sld7 in Yeast Aging Network. / 02.2017 / PubMed / Full text

MTNR1A

Influence of melatonin receptor 1A gene polymorphisms on seasonal reproduction in Sarda ewes with different body condition scores and ages. / 10.2014 / PubMed / Full text

MUC1

Sensitivity of neoplastic cells to senescence unveiled under standard cell culture conditions. / 05.2015 / PubMed

MUC7

Reduced Salivary Mucin Binding and Glycosylation in Older Adults Influences Taste in an In Vitro Cell Model. / 24.09.2019 / PubMed / Full text

MUL1

Effects of MUL1 and PARKIN on the circadian clock, brain and behaviour in Drosophila Parkinson's disease models. / 28.05.2019 / PubMed / Full text

MUTYH

Cholangiocyte senescence caused by lysophosphatidylcholine as a potential implication in carcinogenesis. / 09.2015 / PubMed / Full text

MX1

Age-Associated Changes in the Respiratory Epithelial Response to Influenza Infection. / 10.11.2018 / PubMed / Full text

MYBBP1A

The protein-interaction network with functional roles in tumorigenesis, neurodegeneration, and aging. / 12.2016 / PubMed / Full text

MYBL2

Molecular mechanism of G arrest and cellular senescence induced by LEE011, a novel CDK4/CDK6 inhibitor, in leukemia cells. / 2017 / PubMed / Full text

MYBPC1

Myosin Binding Protein-C Slow Phosphorylation is Altered in Duchenne Dystrophy and Arthrogryposis Myopathy in Fast-Twitch Skeletal Muscles. / 19.08.2015 / PubMed / Full text

MYCN

Silencing of AURKA augments the antitumor efficacy of the AURKA inhibitor MLN8237 on neuroblastoma cells. / 2020 / PubMed / Full text

MYCNOS

Insights into the Function of Long Noncoding RNAs in Sepsis Revealed by Gene Co-Expression Network Analysis. / 26.01.2017 / PubMed / Full text

MYH10

Epigenome-wide exploratory study of monozygotic twins suggests differentially methylated regions to associate with hand grip strength. / 10.2019 / PubMed / Full text

MYH9

Estimated glomerular filtration rate (eGFR), 25(OH) D3, chronic kidney disease (CKD), the MYH9 (myosin heavy chain 9) gene in old and very elderly people. / 08.2015 / PubMed / Full text

MYLPF

Explaining meat quality of bulls and steers by differential proteome and phosphoproteome analysis of skeletal muscle. / 15.05.2019 / PubMed / Full text

MYNN

Genome wide association and linkage analyses identified three loci-4q25, 17q23.2, and 10q11.21-associated with variation in leukocyte telomere length: the Long Life Family Study. / 2013 / PubMed / Full text

MYO1F

A Microglial Signature Directing Human Aging and Neurodegeneration-Related Gene Networks. / 2019 / PubMed / Full text

MYO5B

Genome-Wide Association Analysis of the Sense of Smell in U.S. Older Adults: Identification of Novel Risk Loci in African-Americans and European-Americans. / 12.2017 / PubMed / Full text

MYOC

Binding of a glaucoma-associated myocilin variant to the αB-crystallin chaperone impedes protein clearance in trabecular meshwork cells. / 28.12.2018 / PubMed / Full text

MYOCD

Aging-associated changes in microRNA expression profile of internal anal sphincter smooth muscle: Role of microRNA-133a. / 01.11.2016 / PubMed / Full text

MYOF

Genetics of Human Longevity From Incomplete Data: New Findings From the Long Life Family Study. / 08.10.2018 / PubMed / Full text

MYOG

Low Six4 and Six5 gene dosage improves dystrophic phenotype and prolongs life span of mdx mice. / 08.2016 / PubMed / Full text

MYSM1

MYSM1 Suppresses Cellular Senescence and the Aging Process to Prolong Lifespan. / 11.2020 / PubMed / Full text

MYT1

ESC-sEVs Rejuvenate Aging Hippocampal NSCs by Transferring SMADs to Regulate the MYT1-Egln3-Sirt1 Axis. / 01.10.2020 / PubMed / Full text

NACA

Age and Sex Are Strongly Correlated to the Rate and Type of Mountain Injuries Requiring Search and Rescue Missions. / 12.2019 / PubMed / Full text

NAIP

Protective effect of xanthohumol against age-related brain damage. / 11.2017 / PubMed / Full text

NBPF6

Genomewide Association Scan of a Mortality Associated Endophenotype for a Long and Healthy Life in the Long Life Family Study. / 01.10.2017 / PubMed / Full text

NCAM1

Resistance Training Enhances Skeletal Muscle Innervation Without Modifying the Number of Satellite Cells or their Myofiber Association in Obese Older Adults. / 10.2016 / PubMed / Full text

NCK2

Genetic associations with age of menopause in familial longevity. / 10.2019 / PubMed / Full text

NCOR2

DNA methylation analysis on purified neurons and glia dissects age and Alzheimer's disease-specific changes in the human cortex. / 25.07.2018 / PubMed / Full text

NDN

The Changing Landscape of Naive T Cell Receptor Repertoire With Human Aging. / 2018 / PubMed / Full text

NDP

Association between Cognitive Status before Surgery and Outcomes in Elderly Patients with Hip Fracture in a Dedicated Orthogeriatric Care Pathway. / 2017 / PubMed / Full text

NDUFA9

Preservation of skeletal muscle mitochondrial content in older adults: relationship between mitochondria, fibre type and high-intensity exercise training. / 01.06.2017 / PubMed / Full text

NDUFAB1

Proteomics and metabolomics identify molecular mechanisms of aging potentially predisposing for chronic lymphocytic leukemia. / 02.2018 / PubMed / Full text

NDUFS3

Elucidation of the mechanism of changes in the antioxidant function with the aging in the liver of the senescence-accelerated mouse P10 (SAMP10). / 06.2018 / PubMed / Full text

NDUFS7

Nod-like receptor pyrin containing 3 (NLRP3) in the post-mortem frontal cortex from patients with bipolar disorder: A potential mediator between mitochondria and immune-activation. / 01.2016 / PubMed / Full text

NDUFS8

Mitochondrial Complex I Mutations Predispose Drosophila to Isoflurane Neurotoxicity. / 01.10.2020 / PubMed / Full text

NDUFV1

Contribution of genetic polymorphisms on functional status at very old age: a gene-based analysis of 38 genes (311 SNPs) in the oxidative stress pathway. / 04.2014 / PubMed / Full text

NEBL

Isolation and characterization of the human immature osteoblast culture system from the alveolar bones of aged donors for bone regeneration therapy. / 12.2014 / PubMed / Full text

NEDD4

Estrogen receptor β, a regulator of androgen receptor signaling in the mouse ventral prostate. / 09.05.2017 / PubMed / Full text

NEIL2

Neil2-null Mice Accumulate Oxidized DNA Bases in the Transcriptionally Active Sequences of the Genome and Are Susceptible to Innate Inflammation. / 09.10.2015 / PubMed / Full text

NEIL3

Age-Related Oxidative Changes in Primary Porcine Fibroblasts Expressing Mutated Huntingtin. / 2019 / PubMed / Full text

NEK2

Upregulation of FOXM1 leads to diminished drug sensitivity in myeloma. / 21.11.2018 / PubMed / Full text

NEK9

Effect of sex, age and genetics on crossover interference in cattle. / 28.11.2016 / PubMed / Full text

NELL1

Pharmacogenomics study of thiazide diuretics and QT interval in multi-ethnic populations: the cohorts for heart and aging research in genomic epidemiology. / 04.2018 / PubMed / Full text

NEU1

Sialylation regulates myofibroblast differentiation of human skin fibroblasts. / 18.04.2017 / PubMed / Full text

NF2

Rac1-Mediated DNA Damage and Inflammation Promote Nf2 Tumorigenesis but Also Limit Cell-Cycle Progression. / 21.11.2016 / PubMed / Full text

NFIA

Cell-type-specific expression of NFIX in the developing and adult cerebellum. / 07.2017 / PubMed / Full text

NFIL3

[Identification of single nucleotide polymorphisms in centenarians]. / 05-06.2016 / PubMed / Full text

NFIX

Cell-type-specific expression of NFIX in the developing and adult cerebellum. / 07.2017 / PubMed / Full text

NFKB2

Partial sleep deprivation activates the DNA damage response (DDR) and the senescence-associated secretory phenotype (SASP) in aged adult humans. / 01.2016 / PubMed / Full text

NFKBIA

Analysis of molecular networks and targets mining of Chinese herbal medicines on anti-aging. / 28.12.2016 / PubMed / Full text

NIN

Increased macromolecular damage due to oxidative stress in the neocortex and hippocampus of WNIN/Ob, a novel rat model of premature aging. / 06.06.2014 / PubMed / Full text

NKAP

NKAP Regulates Senescence and Cell Death Pathways in Hematopoietic Progenitors. / 2019 / PubMed / Full text

NKIRAS2

Chronological age prediction based on DNA methylation: Massive parallel sequencing and random forest regression. / 11.2017 / PubMed / Full text

NKX2-1

Epigenetic mechanisms of peptidergic regulation of gene expression during aging of human cells. / 03.2015 / PubMed / Full text

NKX2-5

Isolation, Characterization, and Differentiation of Cardiac Stem Cells from the Adult Mouse Heart. / 07.01.2019 / PubMed / Full text

NKX6-1

The dynamic methylome of islets in health and disease. / 09.2019 / PubMed / Full text

NLRC5

Methylation of the genes ROD1, NLRC5, and HKR1 is associated with aging in Hainan centenarians. / 02.02.2018 / PubMed / Full text

NLRP5

Effects of aging in the expression of NOD-like receptors and inflammasome-related genes in oral mucosa. / 02.2016 / PubMed / Full text

NLRP6

LRP6 targeting suppresses gastric tumorigenesis via P14 -Mdm2-P53-dependent cellular senescence. / 19.12.2017 / PubMed / Full text

NMI

Age-Dependent Control of Shoulder Muscles During a Reach-and-Lift Task. / 10.12.2019 / PubMed / Full text

NMNAT3

Restoration of Mitochondrial NAD Levels Delays Stem Cell Senescence and Facilitates Reprogramming of Aged Somatic Cells. / 12.2016 / PubMed / Full text

NMRK2

Aged Nicotinamide Riboside Kinase 2 Deficient Mice Present an Altered Response to Endurance Exercise Training. / 2018 / PubMed / Full text

NMUR1

[Medicinal Chemistry Focused on Mid-sized Peptides Derived from Biomolecules]. / 2019 / PubMed / Full text

NOBOX

Observation of the influences of diosgenin on aging ovarian reserve and function in a mouse model. / 18.10.2017 / PubMed / Full text

NOD2

Molecular modeling in the age of clinical genomics, the enterprise of the next generation. / 03.2017 / PubMed / Full text

NOL12

NOL12 Repression Induces Nucleolar Stress-Driven Cellular Senescence and Is Associated with Normative Aging. / 15.06.2019 / PubMed / Full text

NOLC1

Enhanced NOLC1 promotes cell senescence and represses hepatocellular carcinoma cell proliferation by disturbing the organization of nucleolus. / 08.2017 / PubMed / Full text

NOTCH4

Age-dependent autophagy induction after injury promotes axon regeneration by limiting NOTCH. / 11.2020 / PubMed / Full text

NPBWR1

Genome-wide association study and annotating candidate gene networks affecting age at first calving in Nellore cattle. / 12.2017 / PubMed / Full text

NPFFR2

Genome-wide association study for longevity with whole-genome sequencing in 3 cattle breeds. / 09.2016 / PubMed / Full text

NPPB

Chloride channels are involved in sperm motility and are downregulated in spermatozoa from patients with asthenozoospermia. / 07-08.2017 / PubMed / Full text

NPRL2

KLHL22 activates amino-acid-dependent mTORC1 signalling to promote tumorigenesis and ageing. / 05.2018 / PubMed / Full text

NPRL3

KLHL22 activates amino-acid-dependent mTORC1 signalling to promote tumorigenesis and ageing. / 05.2018 / PubMed / Full text

NPY1R

NPY/neuropeptide Y enhances autophagy in the hypothalamus: a mechanism to delay aging? / 2015 / PubMed / Full text

NPY2R

Effects of Age and Estradiol on Gene Expression in the Rhesus Macaque Hypothalamus. / 2015 / PubMed / Full text

NPY5R

NPY/neuropeptide Y enhances autophagy in the hypothalamus: a mechanism to delay aging? / 2015 / PubMed / Full text

NQO2

The ontogeny and population variability of human hepatic dihydronicotinamide riboside:quinone oxidoreductase (NQO2). / 08.2017 / PubMed / Full text

NR1H3

Association of levels of fasting glucose and insulin with rare variants at the chromosome 11p11.2-MADD locus: Cohorts for Heart and Aging Research in Genomic Epidemiology (CHARGE) Consortium Targeted Sequencing Study. / 06.2014 / PubMed / Full text

NR2C2

Minireview: Pathophysiological roles of the TR4 nuclear receptor: lessons learned from mice lacking TR4. / 06.2014 / PubMed / Full text

NR5A2

Genome-Wide Association Analysis of the Sense of Smell in U.S. Older Adults: Identification of Novel Risk Loci in African-Americans and European-Americans. / 12.2017 / PubMed / Full text

NRARP

Low dose Emodin induces tumor senescence for boosting breast cancer chemotherapy via silencing NRARP. / 10.11.2018 / PubMed / Full text

NRL

Development of a cyclophosphamide stress test to predict resilience to aging in mice. / 12.2020 / PubMed / Full text

NRP1

Neuropilin 1 is essential for gastrointestinal smooth muscle contractility and motility in aged mice. / 2015 / PubMed / Full text

NRSN2

Down-Regulated NRSN2 Promotes Cell Proliferation and Survival Through PI3K/Akt/mTOR Pathway in Hepatocellular Carcinoma. / 10.2015 / PubMed / Full text

NRXN2

Neurexins 1-3 Each Have a Distinct Pattern of Expression in the Early Developing Human Cerebral Cortex. / 01.01.2017 / PubMed / Full text

NSF

Effects of air pollution on children from a socioecological perspective. / 15.11.2019 / PubMed / Full text

NSMCE2

NSMCE2 suppresses cancer and aging in mice independently of its SUMO ligase activity. / 03.11.2015 / PubMed / Full text

NSUN2

RNA methyltransferase NSUN2 promotes stress-induced HUVEC senescence. / 12.04.2016 / PubMed / Full text

NSUN5

Methylation of ribosomal RNA by NSUN5 is a conserved mechanism modulating organismal lifespan. / 30.01.2015 / PubMed / Full text

NT5E

The NT5E gene variant strongly affects the degradation rate of inosine 5'-monophosphate under postmortem conditions in Japanese Black beef. / 12.2019 / PubMed / Full text

NTHL1

Mitochondrial base excision repair positively correlates with longevity in the liver and heart of mammals. / 04.2020 / PubMed / Full text

NTM

Attenuated heme oxygenase-1 responses predispose the elderly to pulmonary nontuberculous mycobacterial infections. / 01.11.2016 / PubMed / Full text

NTN4

EGF/EGFR upregulates and cooperates with Netrin-4 to protect glioblastoma cells from DNA damage-induced senescence. / 04.12.2018 / PubMed / Full text

NTRK2

The Role of BDNF in Age-Dependent Changes of Excitatory and Inhibitory Synaptic Markers in the Human Prefrontal Cortex. / 12.2016 / PubMed / Full text

NUBP2

Genomewide meta-analysis identifies loci associated with IGF-I and IGFBP-3 levels with impact on age-related traits. / 10.2016 / PubMed / Full text

NUCB2

Ontogenetic Pattern Changes of Nucleobindin-2/Nesfatin-1 in the Brain and Intestinal Bulb of the Short Lived African Turquoise Killifish. / 31.12.2019 / PubMed / Full text

NUPR1

NUPR1 maintains autolysosomal efflux by activating SNAP25 transcription in cancer cells. / 2018 / PubMed / Full text

NVL

[The effectiveness of non-invasive lung ventilation in lateral amyotrophic sclerosis]. / 2014 / PubMed

OCLN

Reduction of Aging-Induced Oxidative Stress and Activation of Autophagy by Bilberry Anthocyanin Supplementation via the AMPK-mTOR Signaling Pathway in Aged Female Rats. / 17.07.2019 / PubMed / Full text

OCRL

Decreased urinary excretion of the ectodomain form of megalin (A-megalin) in children with OCRL gene mutations. / 04.2017 / PubMed / Full text

OGFOD1

2-Oxoglutarate-dependent dioxygenases are sensors of energy metabolism, oxygen availability, and iron homeostasis: potential role in the regulation of aging process. / 10.2015 / PubMed / Full text

OGN

Muscle and bone, two interconnected tissues. / 05.2015 / PubMed / Full text

OLFML3

Dexamethasone Induces a Specific Form of Ramified Dysfunctional Microglia. / 02.2019 / PubMed / Full text

OMA1

'Mitotherapy' for Heart Failure. / 04.2016 / PubMed / Full text

OMD

Genome-wide associations and detection of potential candidate genes for direct genetic and maternal genetic effects influencing dairy cattle body weight at different ages. / 06.02.2019 / PubMed / Full text

OOEP

Maternal gene [i]Ooep[/i] may participate in homologous recombination-mediated DNA double-strand break repair in mouse oocytes. / 18.11.2018 / PubMed / Full text

OPTN

Frontotemporal dementia: insights into the biological underpinnings of disease through gene co-expression network analysis. / 24.02.2016 / PubMed / Full text

OR2AG1

The activation of OR51E1 causes growth suppression of human prostate cancer cells. / 26.07.2016 / PubMed / Full text

OR51E1

The activation of OR51E1 causes growth suppression of human prostate cancer cells. / 26.07.2016 / PubMed / Full text

OR51E2

The activation of OR51E1 causes growth suppression of human prostate cancer cells. / 26.07.2016 / PubMed / Full text

ORAI1

Calcium Dynamics of Ex Vivo Long-Term Cultured CD8 T Cells Are Regulated by Changes in Redox Metabolism. / 2016 / PubMed / Full text

ORC2

mTOR signaling in aging and neurodegeneration: At the crossroad between metabolism dysfunction and impairment of autophagy. / 12.2015 / PubMed / Full text

OSCAR

Awareness tool for safe and responsible driving ([[OSCAR]]): a potential educational intervention for increasing interest, openness and knowledge about the abilities required and compensatory strategies among older drivers. / 2015 / PubMed / Full text

OSGEP

Novel homozygous OSGEP gene pathogenic variants in two unrelated patients with Galloway-Mowat syndrome: case report and review of the literature. / 11.04.2019 / PubMed / Full text

P2RY10

Divergent age-dependent peripheral immune transcriptomic profile following traumatic brain injury. / 12.06.2019 / PubMed / Full text

P4HA2

Expanding the Phenotypic and Genotypic Landscape of Nonsyndromic High Myopia: A Cross-Sectional Study in 731 Chinese Patients. / 03.09.2019 / PubMed / Full text

P4HA3

Age-associated genes in human mammary gland drive human breast cancer progression. / 15.06.2020 / PubMed / Full text

PABPC1

Comprehensive Analysis of Interaction Networks of Telomerase Reverse Transcriptase with Multiple Bioinformatic Approaches: Deep Mining the Potential Functions of Telomere and Telomerase. / 08.2017 / PubMed / Full text

PACSIN1

GluN3A promotes dendritic spine pruning and destabilization during postnatal development. / 09.07.2014 / PubMed / Full text

PAFAH2

Elevated truncated oxidized phospholipids as a factor exacerbating ALI in the aging lungs. / 03.2019 / PubMed / Full text

PAK2

Targeting genes in insulin-associated signalling pathway, DNA damage, cell proliferation and cell differentiation pathways by tocotrienol-rich fraction in preventing cellular senescence of human diploid fibroblasts. / 11-12.2015 / PubMed / Full text

PALB2

A Multigene Test Could Cost-Effectively Help Extend Life Expectancy for Women at Risk of Hereditary Breast Cancer. / 04.2017 / PubMed / Full text

PALM

Signatures of malaria vaccine efficacy in ageing murine immune memory. / 05.2014 / PubMed / Full text

PAPSS1

Genome wide association and linkage analyses identified three loci-4q25, 17q23.2, and 10q11.21-associated with variation in leukocyte telomere length: the Long Life Family Study. / 2013 / PubMed / Full text

PARG

[Genotype and allele frequencies of UCP and PPAR gene families in residents of besieged Leningrad and in the control group]. / 2014 / PubMed

PARP2

Molecular evolutionary patterns of NAD /Sirtuin aging signaling pathway across taxa. / 2017 / PubMed / Full text

PATE1

Aged men share the sperm protein PATE1 defect with young asthenozoospermia patients. / 04.2015 / PubMed / Full text

PAX1

Co-culturing nucleus pulposus mesenchymal stem cells with notochordal cell-rich nucleus pulposus explants attenuates tumor necrosis factor-α-induced senescence. / 26.06.2018 / PubMed / Full text

PAX4

Epigenetic mechanisms of peptidergic regulation of gene expression during aging of human cells. / 03.2015 / PubMed / Full text

PAX7

Muscle health and performance in monozygotic twins with 30 years of discordant exercise habits. / 10.2018 / PubMed / Full text

PAX8

Inadequate control of thyroid hormones sensitizes to hepatocarcinogenesis and unhealthy aging. / 13.09.2019 / PubMed / Full text

PCBP2

RNA-binding Protein PCBP2 Regulates p73 Expression and p73-dependent Antioxidant Defense. / 29.04.2016 / PubMed / Full text

PCCA

Propionyl-CoA carboxylase pcca-1 and pccb-1 gene deletions in Caenorhabditis elegans globally impair mitochondrial energy metabolism. / 03.2018 / PubMed / Full text

PCCB

Propionyl-CoA carboxylase pcca-1 and pccb-1 gene deletions in Caenorhabditis elegans globally impair mitochondrial energy metabolism. / 03.2018 / PubMed / Full text

PCDH9

A reverse genetics cell-based evaluation of genes linked to healthy human tissue age. / 01.2017 / PubMed / Full text

PCDHGA3

DNA methylation associated with healthy aging of elderly twins. / 12.2018 / PubMed / Full text

PCK1

PCK1 is negatively regulated by bta-miR-26a, and a single-nucleotide polymorphism in the 3' untranslated region is involved in semen quality and longevity of Holstein bulls. / 03.2016 / PubMed / Full text

PCMTD1

Genome-wide association study and annotating candidate gene networks affecting age at first calving in Nellore cattle. / 12.2017 / PubMed / Full text

PCP4

Specific age-related molecular alterations in the cerebellum of Down syndrome mouse models. / 01.09.2016 / PubMed / Full text

PDE2A

TAK-915, a phosphodiesterase 2A inhibitor, ameliorates the cognitive impairment associated with aging in rodent models. / 30.12.2019 / PubMed / Full text

PDE3A

Effects of aging on gene expression and mitochondrial DNA in the equine oocyte and follicle cells. / 07.2015 / PubMed / Full text

PDE5A

Repurposing erectile dysfunction drugs tadalafil and vardenafil to increase bone mass. / 23.06.2020 / PubMed / Full text

PDE9A

Identification of new PDE9A isoforms and how their expression and subcellular compartmentalization in the brain change across the life span. / 05.2018 / PubMed / Full text

PDGFRA

GBM-associated mutations and altered protein expression are more common in young patients. / 25.10.2016 / PubMed / Full text

PDHB

Neuron-specific knockdown of Drosophila PDHB induces reduction of lifespan, deficient locomotive ability, abnormal morphology of motor neuron terminals and photoreceptor axon targeting. / 15.05.2018 / PubMed / Full text

PDP1

Age-related impairments in skeletal muscle PDH phosphorylation and plasma lactate are indicative of metabolic inflexibility and the effects of exercise training. / 01.07.2016 / PubMed / Full text

PDP2

Age-related impairments in skeletal muscle PDH phosphorylation and plasma lactate are indicative of metabolic inflexibility and the effects of exercise training. / 01.07.2016 / PubMed / Full text

PEBP1

[i]Drosophila[/i] PEBP1 inhibits intestinal stem cell aging via suppression of ERK pathway. / 06.04.2018 / PubMed / Full text

PER3

Effects of PER3 clock gene polymorphisms on aging-related changes of the cerebral cortex. / 03.2018 / PubMed / Full text

PEX1

Transcription factor PEX1 modulates extracellular matrix turnover through regulation of MMP-9 expression. / 02.2017 / PubMed / Full text

PEX19

A genome-wide screen identifies genes that suppress the accumulation of spontaneous mutations in young and aged yeast cells. / 02.2020 / PubMed / Full text

PEX5

Aging lowers PEX5 levels in cortical neurons in male and female mouse brains. / 09.2020 / PubMed / Full text

PF4V1

Involvement of ERK1/2 activation in the gene expression of senescence-associated secretory factors in human hepatic stellate cells. / 05.2019 / PubMed / Full text

PFKL

Developmental changes in hepatic glucose metabolism in a newborn piglet model: A comparative analysis for suckling period and early weaning period. / 19.02.2016 / PubMed / Full text

PGAM1

The aged testis. A good model to find proteins involved in age-related changes of testis by proteomic analysis. / 01-02.2014 / PubMed

PGAP1

Hypoxia-inducible transcription factors, HIF1A and HIF2A, increase in aging mucosal tissues. / 07.2018 / PubMed / Full text

PGK2

Arsenic influences spermatogenesis by disorganizing the elongation of spermatids in adult male mice. / 01.2020 / PubMed / Full text

PGLS

547 transcriptomes from 44 brain areas reveal features of the aging brain in non-human primates. / 28.11.2019 / PubMed / Full text

PGLYRP1

PGRP-SC2 promotes gut immune homeostasis to limit commensal dysbiosis and extend lifespan. / 16.01.2014 / PubMed / Full text

PGM1

Explaining meat quality of bulls and steers by differential proteome and phosphoproteome analysis of skeletal muscle. / 15.05.2019 / PubMed / Full text

PHF19

A reverse genetics cell-based evaluation of genes linked to healthy human tissue age. / 01.2017 / PubMed / Full text

PHF6

miR-128 regulates neuronal migration, outgrowth and intrinsic excitability via the intellectual disability gene Phf6. / 03.01.2015 / PubMed / Full text

PHGDH

Tanshinone prevents alveolar bone loss in ovariectomized osteoporosis rats by up-regulating phosphoglycerate dehydrogenase. / 01.08.2019 / PubMed / Full text

PHLPP1

Defects in the CAPN1 Gene Result in Alterations in Cerebellar Development and Cerebellar Ataxia in Mice and Humans. / 28.06.2016 / PubMed / Full text

PHOSPHO1

Phospho1 deficiency transiently modifies bone architecture yet produces consistent modification in osteocyte differentiation and vascular porosity with ageing. / 12.2015 / PubMed / Full text

PI4KA

Combined aerobic exercise and enzyme replacement therapy rejuvenates the mitochondrial-lysosomal axis and alleviates autophagic blockage in Pompe disease. / 10.2015 / PubMed / Full text

PICK1

Development- and age-related alterations in the expression of AMPA receptor subunit GluR2 and its trafficking proteins in the hippocampus of male mouse brain. / 06.2015 / PubMed / Full text

PIGR

Proteomics and metabolomics identify molecular mechanisms of aging potentially predisposing for chronic lymphocytic leukemia. / 02.2018 / PubMed / Full text

PIK3C2A

Identification of key genes and transcription factors in aging mesenchymal stem cells by DNA microarray data. / 15.04.2019 / PubMed / Full text

PIK3C3

Metabolomic analyses reveal that anti-aging metabolites are depleted by palmitate but increased by oleate in vivo. / 03.08.2015 / PubMed / Full text

PIK3CB

Coordinated Expression of Phosphoinositide Metabolic Genes during Development and Aging of Human Dorsolateral Prefrontal Cortex. / 2015 / PubMed / Full text

PIK3R1

Analysis of Polymorphisms in 59 Potential Candidate Genes for Association With Human Longevity. / 08.10.2018 / PubMed / Full text

PIK3R3

Coordinated Expression of Phosphoinositide Metabolic Genes during Development and Aging of Human Dorsolateral Prefrontal Cortex. / 2015 / PubMed / Full text

PIM1

PIM1-catalyzed CBX8 phosphorylation promotes the oncogene-induced senescence of human diploid fibroblast. / 27.06.2018 / PubMed / Full text

PIP5K1C

[Target protein candidates of hypothalamus in aging rats with intervention by Qiongyugao]. / 04.2016 / PubMed / Full text

PIPOX

Aging related methylation influences the gene expression of key control genes in colorectal cancer and adenoma. / 21.12.2016 / PubMed / Full text

PIR

Proteomic analysis of changes in mitochondrial protein expression during peach fruit ripening and senescence. / 16.09.2016 / PubMed / Full text

PKD1

The protein kinase D1-mediated classical protein secretory pathway regulates the Ras oncogene-induced senescence response. / 16.03.2018 / PubMed / Full text

PKHD1L1

[Role of PLAT, PKHD1L1, STK38L and TEAD1 genes Alu-polymorphism for longevity]. / 2016 / PubMed

PKLR

Developmental changes in hepatic glucose metabolism in a newborn piglet model: A comparative analysis for suckling period and early weaning period. / 19.02.2016 / PubMed / Full text

PKP2

Molecular disturbance underlies to arrhythmogenic cardiomyopathy induced by transgene content, age and exercise in a truncated PKP2 mouse model. / 01.09.2016 / PubMed / Full text

PLA2G4A

Coordination of gene expression of arachidonic and docosahexaenoic acid cascade enzymes during human brain development and aging. / 2014 / PubMed / Full text

PLAGL1

Exercise-associated DNA methylation change in skeletal muscle and the importance of imprinted genes: a bioinformatics meta-analysis. / 12.2015 / PubMed / Full text

PLAT

[Role of PLAT, PKHD1L1, STK38L and TEAD1 genes Alu-polymorphism for longevity]. / 2016 / PubMed

PLCB1

Coordinated Expression of Phosphoinositide Metabolic Genes during Development and Aging of Human Dorsolateral Prefrontal Cortex. / 2015 / PubMed / Full text

PLCD1

Coordinated Expression of Phosphoinositide Metabolic Genes during Development and Aging of Human Dorsolateral Prefrontal Cortex. / 2015 / PubMed / Full text

PLCG2

A nonsynonymous mutation in PLCG2 reduces the risk of Alzheimer's disease, dementia with Lewy bodies and frontotemporal dementia, and increases the likelihood of longevity. / 08.2019 / PubMed / Full text

PLEC

Cell senescence abrogates the therapeutic potential of human mesenchymal stem cells in the lethal endotoxemia model. / 07.2014 / PubMed / Full text

PLEKHO1

Increased PLEKHO1 within osteoblasts suppresses Smad-dependent BMP signaling to inhibit bone formation during aging. / 04.2017 / PubMed / Full text

PLIN1

Determination of the Mechanisms that Cause Sarcopenia through cDNA Microarray. / 2017 / PubMed / Full text

PLK1

Dynactin pathway-related gene expression is altered by aging, but not by vitrification. / 09.2019 / PubMed / Full text

PLK2

Age- and brain region-dependent α-synuclein oligomerization is attributed to alterations in intrinsic enzymes regulating α-synuclein phosphorylation in aging monkey brains. / 23.02.2016 / PubMed / Full text

PLXNA4

Novel molecular mechanisms for the adaptogenic effects of herbal extracts on isolated brain cells using systems biology. / 15.11.2018 / PubMed / Full text

PMM2

Synaptic roles for phosphomannomutase type 2 in a new Drosophila congenital disorder of glycosylation disease model. / 01.05.2016 / PubMed / Full text

PMP22

Role of microRNAs in senescence and its contribution to peripheral neuropathy in the arsenic exposed population of West Bengal, India. / 02.2018 / PubMed / Full text

PMS1

RNA-Seq analysis of differentially expressed genes relevant to mismatch repair in aging hematopoietic stem-progenitor cells. / 25.02.2019 / PubMed / Full text

PMS2

RNA-Seq analysis of differentially expressed genes relevant to mismatch repair in aging hematopoietic stem-progenitor cells. / 25.02.2019 / PubMed / Full text

PNPLA6

Delayed Induction of Human NTE (PNPLA6) Rescues Neurodegeneration and Mobility Defects of Drosophila swiss cheese (sws) Mutants. / 2015 / PubMed / Full text

PODXL

Induced Pluripotent Stem Cell-Derived Dopaminergic Neurons from Adult Common Marmoset Fibroblasts. / 01.09.2017 / PubMed / Full text

POLDIP2

Essential role of POLDIP2 in Tau aggregation and neurotoxicity via autophagy/proteasome inhibition. / 26.06.2015 / PubMed / Full text

POLL

Temporal trends in loss of life expectancy after a cancer diagnosis among the Australian population. / 04.2020 / PubMed / Full text

POLN

Analysis of DNA polymerase ν function in meiotic recombination, immunoglobulin class-switching, and DNA damage tolerance. / 06.2017 / PubMed / Full text

POLR3A

Nucleolar disruption, activation of P53 and premature senescence in POLR3A-mutated Wiedemann-Rautenstrauch syndrome fibroblasts. / 12.2020 / PubMed / Full text

POU2F1

Methyl CpG level at distal part of heat-shock protein promoter HSP70 exhibits epigenetic memory for heat stress by modulating recruitment of POU2F1-associated nucleosome-remodeling deacetylase (NuRD) complex. / 05.2017 / PubMed / Full text

POU3F2

POU3F2 participates in cognitive function and adult hippocampal neurogenesis via mammalian-characteristic amino acid repeats. / 02.2018 / PubMed / Full text

POU4F3

In Vivo Interplay between p27 , GATA3, ATOH1, and POU4F3 Converts Non-sensory Cells to Hair Cells in Adult Mice. / 11.04.2017 / PubMed / Full text

PPA2

Characterization of long living yeast deletion mutants that lack mitochondrial metabolism genes DSS1, PPA2 and AFG3. / 20.07.2019 / PubMed / Full text

PPARA

[Genotype and allele frequencies of UCP and PPAR gene families in residents of besieged Leningrad and in the control group]. / 2014 / PubMed

PPFIA1

Explorative results from multistep screening for potential genetic risk loci of Alzheimer's disease in the longitudinal VITA study cohort. / 01.2018 / PubMed / Full text

PPM1A

The TGF-β1/p53/PAI-1 Signaling Axis in Vascular Senescence: Role of Caveolin-1. / 03.08.2019 / PubMed / Full text

PPM1B

PPM1B depletion induces premature senescence in human IMR-90 fibroblasts. / 06.2014 / PubMed / Full text

PPP1R12B

BDA-410 Treatment Reduces Body Weight and Fat Content by Enhancing Lipolysis in Sedentary Senescent Mice. / 01.08.2017 / PubMed / Full text

PPP1R3C

Uncovering genetic mechanisms of kidney aging through transcriptomics, genomics, and epigenomics. / 03.2019 / PubMed / Full text

PPP2R1A

Identification of key genes and transcription factors in aging mesenchymal stem cells by DNA microarray data. / 15.04.2019 / PubMed / Full text

PPP2R2B

Germline genetics of the p53 pathway affect longevity in a gender specific manner. / 2014 / PubMed / Full text

PPP2R3C

The mir-465 family is upregulated with age and attenuates growth hormone signaling in mouse liver. / 04.2019 / PubMed / Full text

PPP3CB

Gene Expression Analysis Reveals Novel Gene Signatures Between Young and Old Adults in Human Prefrontal Cortex. / 2018 / PubMed / Full text

PRDM1

Age-related changes in the BACH2 and PRDM1 genes in lymphocytes from healthy donors and chronic lymphocytic leukemia patients. / 17.01.2019 / PubMed / Full text

PRDM8

PRDM8 reveals aberrant DNA methylation in aging syndromes and is relevant for hematopoietic and neuronal differentiation. / 20.08.2020 / PubMed / Full text

PRG2

Peritoneal carcinomatosis of colorectal cancer is characterized by structural and functional reorganization of the tumor microenvironment inducing senescence and proliferation arrest in cancer cells. / 2016 / PubMed / Full text

PRG4

Inhibition of Wnt/β-catenin signaling ameliorates osteoarthritis in a murine model of experimental osteoarthritis. / 08.02.2018 / PubMed / Full text

PRKAA1

Therapeutic and preventive effects of exercise on cardiometabolic parameters in aging and obese rats. / 02.2019 / PubMed / Full text

PRKAA2

Effect of testosterone on markers of mitochondrial oxidative phosphorylation and lipid metabolism in muscle of aging men with subnormal bioavailable testosterone. / 07.2014 / PubMed / Full text

PRKCB

MEF2A alters the proliferation, inflammation-related gene expression profiles and its silencing induces cellular senescence in human coronary endothelial cells. / 18.03.2019 / PubMed / Full text

PRKCD

Extended Multiplexing of Tandem Mass Tags (TMT) Labeling Reveals Age and High Fat Diet Specific Proteome Changes in Mouse Epididymal Adipose Tissue. / 05.2017 / PubMed / Full text

PRKCH

Novel molecular mechanisms for the adaptogenic effects of herbal extracts on isolated brain cells using systems biology. / 15.11.2018 / PubMed / Full text

PRKDC

DNA-PKcs modulates progenitor cell proliferation and fibroblast senescence in idiopathic pulmonary fibrosis. / 29.08.2019 / PubMed / Full text

PRKN

PRKN-regulated mitophagy and cellular senescence during COPD pathogenesis. / 03.2019 / PubMed / Full text

PRLR

Novel molecular mechanisms for the adaptogenic effects of herbal extracts on isolated brain cells using systems biology. / 15.11.2018 / PubMed / Full text

PRM1

Cytological and molecular aspects of the ageing sperm. / 01.02.2019 / PubMed / Full text

PRM2

Cytological and molecular aspects of the ageing sperm. / 01.02.2019 / PubMed / Full text

PRODH

Proline dehydrogenase promotes senescence through the generation of reactive oxygen species. / 15.04.2017 / PubMed / Full text

PROX1

Molecular control of two novel migratory paths for CGE-derived interneurons in the developing mouse brain. / 15.05.2016 / PubMed / Full text

PRR9

Circadian control of [i]ORE1[/i] by PRR9 positively regulates leaf senescence in [i]Arabidopsis[/i]. / 14.08.2018 / PubMed / Full text

PRRX1

A SIRT1-centered circuitry regulates breast cancer stemness and metastasis. / 12.2018 / PubMed / Full text

PRSS16

The complex genetics of gait speed: genome-wide meta-analysis approach. / 10.01.2017 / PubMed / Full text

PSAP

Prosaposin and its receptors are differentially expressed in the salivary glands of male and female rats. / 08.2018 / PubMed / Full text

PSMA7

Role of the Ubiquitin C-Terminal Hydrolase L1-Modulated Ubiquitin Proteasome System in Auditory Cortex Senescence. / 2017 / PubMed / Full text

PSMB10

Identification of the activating cytotoxicity receptor NKG2D as a senescence marker in zero-hour kidney biopsies is indicative for clinical outcome. / 06.2017 / PubMed / Full text

PSMB5

Ameliorating replicative senescence of human bone marrow stromal cells by PSMB5 overexpression. / 24.01.2014 / PubMed / Full text

PSMB8

[Target protein candidates of hypothalamus in aging rats with intervention by Qiongyugao]. / 04.2016 / PubMed / Full text

PSMB9

Identification of the activating cytotoxicity receptor NKG2D as a senescence marker in zero-hour kidney biopsies is indicative for clinical outcome. / 06.2017 / PubMed / Full text

PSMD11

The effect and mechanism of 19S proteasome PSMD11/Rpn6 subunit in D-Galactose induced mimetic aging models. / 01.09.2020 / PubMed / Full text

PSMD13

Lifelong Football Training: Effects on Autophagy and Healthy Longevity Promotion. / 2019 / PubMed / Full text

PSMD14

Upregulation of deubiquitinase PSMD14 in lung adenocarcinoma (LUAD) and its prognostic significance. / 2020 / PubMed / Full text

PSMG1

Long-lived rodents reveal signatures of positive selection in genes associated with lifespan. / 03.2018 / PubMed / Full text

PTCH1

Sonic hedgehog regulation of cavernous nerve regeneration and neurite formation in aged pelvic plexus. / 02.2019 / PubMed / Full text

PTER

THE EFFECTS OF XANTHOTOXIN ON THE BIOLOGY AND BIOCHEMISTRY OF Galleria mellonella L. (LEPIDOPTERA: PYRALIDAE). / 08.2015 / PubMed / Full text

PTGDR

Does prostaglandin D2 hold the cure to male pattern baldness? / 04.2014 / PubMed / Full text

PTGDS

Does prostaglandin D2 hold the cure to male pattern baldness? / 04.2014 / PubMed / Full text

PTGER2

Molecular cloning and expression analysis of prostaglandin E receptor 2 gene in cashmere goat (Capra hircus) skin during hair follicle development. / 03.04.2014 / PubMed / Full text

PTH2R

Variation in the [[PTH2R]] gene is associated with age-related degenerative changes in the lumbar spine. / 01.2015 / PubMed / Full text

PTHLH

Variation in the [[PTH2R]] gene is associated with age-related degenerative changes in the lumbar spine. / 01.2015 / PubMed / Full text

PTK2

PTK2 rs7460 and rs7843014 polymorphisms and exceptional longevity: a functional replication study. / 10.2014 / PubMed / Full text

PTK7

Innate and adaptive immune dysregulation in critically ill ICU patients. / 05.07.2018 / PubMed / Full text

PTP4A3

Transcriptional and Functional Changes of the Human Microvasculature during Physiological Aging and Alzheimer Disease. / 05.2020 / PubMed / Full text

PTPN1

The genetic component of human longevity: New insights from the analysis of pathway-based SNP-SNP interactions. / 06.2018 / PubMed / Full text

PTPN7

DNA methylation-based age prediction from saliva: High age predictability by combination of 7 CpG markers. / 07.2017 / PubMed / Full text

PTPRC

Selective molecular biomarkers to predict biologic behavior in pituitary tumors. / 05.2017 / PubMed / Full text

PTPRD

Novel molecular mechanisms for the adaptogenic effects of herbal extracts on isolated brain cells using systems biology. / 15.11.2018 / PubMed / Full text

PTPRR

Novel molecular mechanisms for the adaptogenic effects of herbal extracts on isolated brain cells using systems biology. / 15.11.2018 / PubMed / Full text

PTPRT

The complex genetics of gait speed: genome-wide meta-analysis approach. / 10.01.2017 / PubMed / Full text

PTTG1

[Down-regulated PTTG1 expression promotes the senescence of human prostate cancer LNCaP-AI]. / 03.2019 / PubMed

PUM1

Identification of reference genes for RT-qPCR data normalisation in aging studies. / 27.09.2019 / PubMed / Full text

PXN

pxn-1 and pxn-2 May Interact Negatively during Neuronal Development and Aging in C. elegans. / 08.2015 / PubMed / Full text

QRFPR

Explorative results from multistep screening for potential genetic risk loci of Alzheimer's disease in the longitudinal VITA study cohort. / 01.2018 / PubMed / Full text

RAB1B

Lifelong Football Training: Effects on Autophagy and Healthy Longevity Promotion. / 2019 / PubMed / Full text

RAC3

RAC3 more than a nuclear receptor coactivator: a key inhibitor of senescence that is downregulated in aging. / 15.10.2015 / PubMed / Full text

RAD21

Suppression of RAD21 Induces Senescence of MDA-MB-231 Human Breast Cancer Cells Through RB1 Pathway Activation Via c-Myc Downregulation. / 06.2016 / PubMed / Full text

RAD23A

Lifelong Football Training: Effects on Autophagy and Healthy Longevity Promotion. / 2019 / PubMed / Full text

RAD51B

Increased age-adjusted hazard of death associated with a common single nucleotide polymorphism of the human RAD52 gene in a cardiovascular cohort. / 10.2017 / PubMed / Full text

RAD51C

Polymorphisms of the DNA repair gene EXO1 modulate cognitive aging in old adults in a Taiwanese population. / 06.2019 / PubMed / Full text

RAD9A

Proteomics and metabolomics identify molecular mechanisms of aging potentially predisposing for chronic lymphocytic leukemia. / 02.2018 / PubMed / Full text

RAI1

DNA methylation analysis on purified neurons and glia dissects age and Alzheimer's disease-specific changes in the human cortex. / 25.07.2018 / PubMed / Full text

RAMP1

Depressed perivascular sensory innervation of mouse mesenteric arteries with advanced age. / 15.04.2016 / PubMed / Full text

RAPGEF2

Genome-Wide Association Analysis of the Sense of Smell in U.S. Older Adults: Identification of Novel Risk Loci in African-Americans and European-Americans. / 12.2017 / PubMed / Full text

RARB

Genome-wide meta-analysis of macronutrient intake of 91,114 European ancestry participants from the cohorts for heart and aging research in genomic epidemiology consortium. / 12.2019 / PubMed / Full text

RASEF

Near-genomewide RNAi screening for regulators of BRAF(V600E) -induced senescence identifies RASEF, a gene epigenetically silenced in melanoma. / 07.2014 / PubMed / Full text

RASGEF1A

Genome wide association and linkage analyses identified three loci-4q25, 17q23.2, and 10q11.21-associated with variation in leukocyte telomere length: the Long Life Family Study. / 2013 / PubMed / Full text

RASGRF2

A single nucleotide polymorphism associated with reduced alcohol intake in the RASGRF2 gene predicts larger cortical volumes but faster longitudinal ventricular expansion in the elderly. / 2013 / PubMed / Full text

RASGRP1

Genome-Wide Association Analysis of the Sense of Smell in U.S. Older Adults: Identification of Novel Risk Loci in African-Americans and European-Americans. / 12.2017 / PubMed / Full text

RB1CC1

Tumor-suppressive functions of 15-Lipoxygenase-2 and RB1CC1 in prostate cancer. / 2014 / PubMed / Full text

RBBP4

Retinoblastoma-binding Protein 4-regulated Classical Nuclear Transport Is Involved in Cellular Senescence. / 04.12.2015 / PubMed / Full text

RBL1

Deregulation of hsa-miR-20b expression in TNF-α-induced premature senescence of human pulmonary microvascular endothelial cells. / 11.2017 / PubMed / Full text

RBM25

HPV shapes tumor transcriptome by globally modifying the pool of RNA binding protein-binding motif. / 29.04.2019 / PubMed / Full text

RBM3

Infants Uniquely Express High Levels of RBM3 and Other Cold-Adaptive Neuroprotectant Proteins in the Human Brain. / 2018 / PubMed / Full text

RBM38

Genetic Ablation of [i]Rbm38[/i] Promotes Lymphomagenesis in the Context of Mutant p53 by Downregulating PTEN. / 15.03.2018 / PubMed / Full text

RBM6

Bayesian association scan reveals loci associated with human lifespan and linked biomarkers. / 27.07.2017 / PubMed / Full text

RBMXL1

Whole-Exome Sequencing of an Exceptional Longevity Cohort. / 16.08.2019 / PubMed / Full text

RBP1

The SR proteins SF2 and RBP1 regulate triglyceride storage in the fat body of Drosophila. / 27.08.2019 / PubMed / Full text

RCC1

XRCC1 and XPD genetic polymorphisms and susceptibility to age-related cataract: a meta-analysis. / 2015 / PubMed / Full text

RCC2

XRCC1 and XPD genetic polymorphisms and susceptibility to age-related cataract: a meta-analysis. / 2015 / PubMed / Full text

REL

Impact of loss of NF-κB1, NF-κB2 or c-REL on SLE-like autoimmune disease and lymphadenopathy in Fas(lpr/lpr) mutant mice. / 01.2016 / PubMed / Full text

RELB

New control of the senescence barrier in breast cancer. / 2020 / PubMed / Full text

REV1

REV1 inhibitor JH-RE-06 enhances tumor cell response to chemotherapy by triggering senescence hallmarks. / 17.11.2020 / PubMed / Full text

RGL1

Arabidopsis WRKY45 Interacts with the DELLA Protein RGL1 to Positively Regulate Age-Triggered Leaf Senescence. / 12.09.2017 / PubMed / Full text

RGS1

Age-related changes in regulator of G-protein signaling (RGS)-10 expression in peripheral and central immune cells may influence the risk for age-related degeneration. / 05.2015 / PubMed / Full text

RGS10

Age-related changes in regulator of G-protein signaling (RGS)-10 expression in peripheral and central immune cells may influence the risk for age-related degeneration. / 05.2015 / PubMed / Full text

RGS14

Enhanced longevity and metabolism by brown adipose tissue with disruption of the regulator of G protein signaling 14. / 08.2018 / PubMed / Full text

RGS3

The roles of ribosomal protein S19 C-terminus in a shortened neutrophil lifespan through delta lactoferrin. / 09.2015 / PubMed / Full text

RHCG

Rh type C-glycoprotein functions as a novel tumor suppressor gene by inhibiting tumorigenicity and metastasis in head and neck squamous cell carcinoma. / 06.06.2019 / PubMed / Full text

RHEBL1

Long-lived rodents reveal signatures of positive selection in genes associated with lifespan. / 03.2018 / PubMed / Full text

RHOB

Regulation of RhoB Gene Expression during Tumorigenesis and Aging Process and Its Potential Applications in These Processes. / 13.06.2019 / PubMed / Full text

RIC3

Genetic modifiers of cognitive maintenance among older adults. / 09.2014 / PubMed / Full text

RIF1

53BP1 Enforces Distinct Pre- and Post-resection Blocks on Homologous Recombination. / 02.01.2020 / PubMed / Full text

RIMS2

Age-related gene and miRNA expression changes in airways of healthy individuals. / 06.03.2019 / PubMed / Full text

RIN3

Association and interaction effects of Alzheimer's disease-associated genes and lifestyle on cognitive aging in older adults in a Taiwanese population. / 11.04.2017 / PubMed / Full text

RNASEL

Age-related methylation profiles of equine blood leukocytes in the RNASEL locus. / 08.2016 / PubMed / Full text

RNF10

Reduced RING finger protein 10 expression in macrophages is associated with aging-related inflammation. / 28.11.2020 / PubMed / Full text

RNF111

Global-genome Nucleotide Excision Repair Controlled by Ubiquitin/Sumo Modifiers. / 2016 / PubMed / Full text

RNF13

The effects of environmental stressors on candidate aging associated genes. / 08.2020 / PubMed / Full text

RNF144A

Identification of age- and gender-associated long noncoding RNAs in the human brain with Alzheimer's disease. / 09.2019 / PubMed / Full text

RNF168

PML nuclear bodies are recruited to persistent DNA damage lesions in an RNF168-53BP1 dependent manner and contribute to DNA repair. / 06.2019 / PubMed / Full text

RORB

Effects of circadian clock genes and environmental factors on cognitive aging in old adults in a Taiwanese population. / 11.04.2017 / PubMed / Full text

ROS1

Novel molecular mechanisms for the adaptogenic effects of herbal extracts on isolated brain cells using systems biology. / 15.11.2018 / PubMed / Full text

RP1

Age-Related Decline in Brain and Hepatic Clearance of Amyloid-Beta is Rectified by the Cholinesterase Inhibitors Donepezil and Rivastigmine in Rats. / 20.05.2015 / PubMed / Full text

RPA2

Chronological age prediction based on DNA methylation: Massive parallel sequencing and random forest regression. / 11.2017 / PubMed / Full text

RPL10

Comprehensive analysis of the ubiquitinome during oncogene-induced senescence in human fibroblasts. / 2015 / PubMed / Full text

RPL13

Selection of a Real-Time PCR Housekeeping Gene Panel in Human Endothelial Colony Forming Cells for Cellular Senescence Studies. / 2019 / PubMed / Full text

RPL18

Comprehensive analysis of the ubiquitinome during oncogene-induced senescence in human fibroblasts. / 2015 / PubMed / Full text

RPL3

Comprehensive analysis of the ubiquitinome during oncogene-induced senescence in human fibroblasts. / 2015 / PubMed / Full text

RPL30

Selection of a Real-Time PCR Housekeeping Gene Panel in Human Endothelial Colony Forming Cells for Cellular Senescence Studies. / 2019 / PubMed / Full text

RPL31

Selection of a Real-Time PCR Housekeeping Gene Panel in Human Endothelial Colony Forming Cells for Cellular Senescence Studies. / 2019 / PubMed / Full text

RPL35

Comprehensive analysis of the ubiquitinome during oncogene-induced senescence in human fibroblasts. / 2015 / PubMed / Full text

RPL36

Lifelong Football Training: Effects on Autophagy and Healthy Longevity Promotion. / 2019 / PubMed / Full text

RPL37

Selection of a Real-Time PCR Housekeeping Gene Panel in Human Endothelial Colony Forming Cells for Cellular Senescence Studies. / 2019 / PubMed / Full text

RPL4

Lifelong Football Training: Effects on Autophagy and Healthy Longevity Promotion. / 2019 / PubMed / Full text

RPS11

Comprehensive analysis of the ubiquitinome during oncogene-induced senescence in human fibroblasts. / 2015 / PubMed / Full text

RPS19BP1

Material basis, effect, and mechanism of ethanol extract of Pinellia ternata tubers on oxidative stress-induced cell senescence. / 10.2020 / PubMed / Full text

RPS2

Comprehensive analysis of the ubiquitinome during oncogene-induced senescence in human fibroblasts. / 2015 / PubMed / Full text

RPS20

Comprehensive analysis of the ubiquitinome during oncogene-induced senescence in human fibroblasts. / 2015 / PubMed / Full text

RPS4X

Comprehensive analysis of the ubiquitinome during oncogene-induced senescence in human fibroblasts. / 2015 / PubMed / Full text

RPS6KA1

Genetic analysis of TOR complex gene variation with human longevity: a nested case-control study of American men of Japanese ancestry. / 02.2015 / PubMed / Full text

RPS6KB1

Inhibition of glioma growth by flavokawain B is mediated through endoplasmic reticulum stress induced autophagy. / 2018 / PubMed / Full text

RPS7

Comprehensive analysis of the ubiquitinome during oncogene-induced senescence in human fibroblasts. / 2015 / PubMed / Full text

RRAD

Pan-senescence transcriptome analysis identified RRAD as a marker and negative regulator of cellular senescence. / 01.2019 / PubMed / Full text

RRM2

Increased Rrm2 gene dosage reduces fragile site breakage and prolongs survival of ATR mutant mice. / 01.04.2015 / PubMed / Full text

RRM2B

Troponin T3 associates with DNA consensus sequence that overlaps with p53 binding motifs. / 15.07.2018 / PubMed / Full text

RS1

Retinoschisin gene therapy in photoreceptors, Müller glia or all retinal cells in the Rs1h-/- mouse. / 06.2014 / PubMed / Full text

RSAD2

Progression of pathology in PINK1-deficient mouse brain from splicing via ubiquitination, ER stress, and mitophagy changes to neuroinflammation. / 02.08.2017 / PubMed / Full text

RSF1

The SR proteins SF2 and RBP1 regulate triglyceride storage in the fat body of Drosophila. / 27.08.2019 / PubMed / Full text

RSL1D1

Ribosomal L1 domain and lysine-rich region are essential for CSIG/ RSL1D1 to regulate proliferation and senescence. / 15.01.2016 / PubMed / Full text

RTN3

Dysfunctional tubular endoplasmic reticulum constitutes a pathological feature of Alzheimer's disease. / 09.2016 / PubMed / Full text

RTN4

Cell fate regulation by reticulon-4 in human prostate cancers. / 07.2019 / PubMed / Full text

RUNX3

circLARP4 induces cellular senescence through regulating miR-761/RUNX3/p53/p21 signaling in hepatocellular carcinoma. / 02.2019 / PubMed / Full text

RUVBL2

Proton irradiation impacts age-driven modulations of cancer progression influenced by immune system transcriptome modifications from splenic tissue. / 09.2015 / PubMed / Full text

RXFP1

Sex- and age-specific differences in relaxin family peptide receptor expression within the hippocampus and amygdala in rats. / 22.01.2015 / PubMed / Full text

RXFP3

The RXFP3 receptor is functionally associated with cellular responses to oxidative stress and DNA damage. / 03.12.2019 / PubMed / Full text

RXRA

The nuclear receptor RXRA controls cellular senescence by regulating calcium signaling. / 12.2018 / PubMed / Full text

RXRG

Genetic variations, reproductive aging, and breast cancer risk in African American and European American women: The Women's Circle of Health Study. / 2017 / PubMed / Full text

RYR3

Association of the RYR3 gene polymorphisms with atherosclerosis in elderly Japanese population. / 14.01.2014 / PubMed / Full text

S100A13

S100A13 promotes senescence-associated secretory phenotype and cellular senescence via modulation of non-classical secretion of IL-1α. / 23.01.2019 / PubMed / Full text

S100A6

Sex differences in distribution of cannabinoid receptors (CB1 and CB2), S100A6 and CacyBP/SIP in human ageing hearts. / 27.11.2018 / PubMed / Full text

S100A7

The secreted protein S100A7 (psoriasin) is induced by telomere dysfunction in human keratinocytes independently of a DNA damage response and cell cycle regulators. / 2014 / PubMed / Full text

S100P

Cancer-associated S100P protein binds and inactivates p53, permits therapy-induced senescence and supports chemoresistance. / 19.04.2016 / PubMed / Full text

SAA2

Naturally occurring antibodies against serum amyloid A reduce IL-6 release from peripheral blood mononuclear cells. / 2018 / PubMed / Full text

SACM1L

Coordinated Expression of Phosphoinositide Metabolic Genes during Development and Aging of Human Dorsolateral Prefrontal Cortex. / 2015 / PubMed / Full text

SAMD10

Chronological age prediction based on DNA methylation: Massive parallel sequencing and random forest regression. / 11.2017 / PubMed / Full text

SAMD12

Genome-wide scan of depressive symptomatology in two representative cohorts in the United States and the United Kingdom. / 05.2018 / PubMed / Full text

SAMHD1

Gut microbiota lipopolysaccharide accelerates inflamm-aging in mice. / 16.01.2016 / PubMed / Full text

SARM1

Sarm1 Deletion, but Not Wld , Confers Lifelong Rescue in a Mouse Model of Severe Axonopathy. / 03.10.2017 / PubMed / Full text

SAT1

Triethylenetetramine (trientine): a caloric restriction mimetic with a new mode of action. / 08.2020 / PubMed / Full text

SCAMP1

Secretory Carrier Membrane Protein (SCAMP) deficiency influences behavior of adult flies. / 2014 / PubMed / Full text

SCAMP4

SCAMP4 enhances the senescent cell secretome. / 01.07.2018 / PubMed / Full text

SCD5

Bovine brain region-specific stearoyl-CoA desaturase expression and fatty acid composition. / 06.2015 / PubMed / Full text

SCGB1A1

Epigenetic mechanisms of peptidergic regulation of gene expression during aging of human cells. / 03.2015 / PubMed / Full text

SCGB2A2

Sensitivity of neoplastic cells to senescence unveiled under standard cell culture conditions. / 05.2015 / PubMed

SCGB3A2

Epigenetic mechanisms of peptidergic regulation of gene expression during aging of human cells. / 03.2015 / PubMed / Full text

SCN2A

Na 1.2 haploinsufficiency in Scn2a knock-out mice causes an autistic-like phenotype attenuated with age. / 09.09.2019 / PubMed / Full text

SCN9A

The SCN9A channel and plasma membrane depolarization promote cellular senescence through Rb pathway. / 06.2018 / PubMed / Full text

SCNN1B

Bitter, Sweet, Salty, Sour and Umami Taste Perception Decreases with Age: Sex-Specific Analysis, Modulation by Genetic Variants and Taste-Preference Associations in 18 to 80 Year-Old Subjects. / 18.10.2018 / PubMed / Full text

SCO1

Real-Time PCR Analysis of Metabolism-Related Genes in a Long-Lived Model of C. elegans. / 2020 / PubMed / Full text

SCO2

Role of SCOX in determination of Drosophila melanogaster lifespan. / 2014 / PubMed / Full text

SCRIB

Scribble is required for pregnancy-induced alveologenesis in the adult mammary gland. / 15.06.2016 / PubMed / Full text

SCX

Novel molecular mechanisms for the adaptogenic effects of herbal extracts on isolated brain cells using systems biology. / 15.11.2018 / PubMed / Full text

SDC2

Alterations in Corneal Sensory Nerves During Homeostasis, Aging, and After Injury in Mice Lacking the Heparan Sulfate Proteoglycan Syndecan-1. / 01.10.2017 / PubMed / Full text

SDC3

Alterations in Corneal Sensory Nerves During Homeostasis, Aging, and After Injury in Mice Lacking the Heparan Sulfate Proteoglycan Syndecan-1. / 01.10.2017 / PubMed / Full text

SDHC

Endogenous reactive oxygen species cause astrocyte defects and neuronal dysfunctions in the hippocampus: a new model for aging brain. / 02.2017 / PubMed / Full text

SEC23A

Pancreatic SEC23B deficiency is sufficient to explain the perinatal lethality of germline SEC23B deficiency in mice. / 14.06.2016 / PubMed / Full text

SEC23B

Pancreatic SEC23B deficiency is sufficient to explain the perinatal lethality of germline SEC23B deficiency in mice. / 14.06.2016 / PubMed / Full text

SELENBP1

A Caenorhabditis elegans ortholog of human selenium-binding protein 1 is a pro-aging factor protecting against selenite toxicity. / 01.2020 / PubMed / Full text

SELENOH

The Thioredoxin-Like Family of Selenoproteins: Implications in Aging and Age-Related Degeneration. / 03.2019 / PubMed / Full text

SELENOK

Dietary selenium deficiency and supplementation differentially modulate the expression of two ER-resident selenoproteins (selenoprotein K and selenoprotein M) in the ovaries of aged mice: Preliminary data. / 09.2020 / PubMed / Full text

SELENOP

Analyses of Selenotranscriptomes and Selenium Concentrations in Response to Dietary Selenium Deficiency and Age Reveal Common and Distinct Patterns by Tissue and Sex in Telomere-Dysfunctional Mice. / 10.2017 / PubMed / Full text

SELENOT

The Thioredoxin-Like Family of Selenoproteins: Implications in Aging and Age-Related Degeneration. / 03.2019 / PubMed / Full text

SELENOV

The Thioredoxin-Like Family of Selenoproteins: Implications in Aging and Age-Related Degeneration. / 03.2019 / PubMed / Full text

SELENOW

The Thioredoxin-Like Family of Selenoproteins: Implications in Aging and Age-Related Degeneration. / 03.2019 / PubMed / Full text

SELP

Effect of age on expression of spermatogonial markers in bovine testis and isolated cells. / 07.2016 / PubMed / Full text

SEMA3A

Autoregulation of Osteocyte Sema3A Orchestrates Estrogen Action and Counteracts Bone Aging. / 05.03.2019 / PubMed / Full text

SEMA6C

Suppression of SEMA6C promotes preantral follicles atresia with decreased cell junctions in mice ovaries. / 04.2019 / PubMed / Full text

SENP1

Aging-related SUMOylation pattern in the cortex and blood plasma of wild type mice. / 06.03.2018 / PubMed / Full text

SENP6

Molecular signature for senile and complicated cataracts derived from analysis of sumoylation enzymes and their substrates in human cataract lenses. / 10.2020 / PubMed / Full text

SERPINA1

Proteomic profiling of follicle fluids after superstimulation in one-month-old lambs. / 02.2018 / PubMed / Full text

SERPINB2

An Endogenous Anti-aging Factor, Sonic Hedgehog, Suppresses Endometrial Stem Cell Aging through SERPINB2. / 03.07.2019 / PubMed / Full text

SESN1

Sestrins are differentially expressed with age in the skeletal muscle of men: A cross-sectional analysis. / 09.2018 / PubMed / Full text

SETX

Sen1, the homolog of human Senataxin, is critical for cell survival through regulation of redox homeostasis, mitochondrial function, and the TOR pathway in Saccharomyces cerevisiae. / 11.2016 / PubMed / Full text

SFPQ

Downregulation of LncRNA NORAD promotes Ox-LDL-induced vascular endothelial cell injury and atherosclerosis. / 08.04.2020 / PubMed / Full text

SFRP5

SFRP5 serves a beneficial role in arterial aging by inhibiting the proliferation, migration and inflammation of smooth muscle cells. / 11.2018 / PubMed / Full text

SFTPA1

Epigenetic mechanisms of peptidergic regulation of gene expression during aging of human cells. / 03.2015 / PubMed / Full text

SGCE

Exercise-associated DNA methylation change in skeletal muscle and the importance of imprinted genes: a bioinformatics meta-analysis. / 12.2015 / PubMed / Full text

SGK1

Epigenetic Regulation of KL (Klotho) via H3K27me3 (Histone 3 Lysine [K] 27 Trimethylation) in Renal Tubule Cells. / 05.2020 / PubMed / Full text

SGSH

MPS-IIIA mice acquire autistic behaviours with age. / 07.2018 / PubMed / Full text

SH2B1

The Dyslexia-susceptibility Protein KIAA0319 Inhibits Axon Growth Through Smad2 Signaling. / 01.03.2017 / PubMed / Full text

SH2B3

Genome-wide meta-analysis associates HLA-DQA1/DRB1 and LPA and lifestyle factors with human longevity. / 13.10.2017 / PubMed / Full text

SHC1

Docosahexaenoic acid prevented tumor necrosis factor alpha-induced endothelial dysfunction and senescence. / 01.2016 / PubMed / Full text

SHD

Does self-reported hearing difficulty decrease older adults' cognitive and physical functioning? The mediating role of social isolation. / 11.2020 / PubMed / Full text

SHMT2

Epigenetic regulation of the nuclear-coded GCAT and SHMT2 genes confers human age-associated mitochondrial respiration defects. / 22.05.2015 / PubMed / Full text

SHOX2

Role of SHOX2 in the development of intervertebral disc degeneration. / 05.2017 / PubMed / Full text

SHROOM3

A roadmap for the genetic analysis of renal aging. / 10.2015 / PubMed / Full text

SIGIRR

Anti-Inflamm-Aging Effects of Long-Term Caloric Restriction via Overexpression of SIGIRR to Inhibit NF-κB Signaling Pathway. / 2015 / PubMed / Full text

SIK3

Quantitative and Qualitative Role of Antagonistic Heterogeneity in Genetics of Blood Lipids. / 25.09.2020 / PubMed / Full text

SIL1

SIL1, the endoplasmic-reticulum-localized BiP co-chaperone, plays a crucial role in maintaining skeletal muscle proteostasis and physiology. / 10.05.2018 / PubMed / Full text

SIX1

Low Six4 and Six5 gene dosage improves dystrophic phenotype and prolongs life span of mdx mice. / 08.2016 / PubMed / Full text

SIX2

Age-Dependent Pancreatic Gene Regulation Reveals Mechanisms Governing Human β Cell Function. / 10.05.2016 / PubMed / Full text

SIX4

Low Six4 and Six5 gene dosage improves dystrophic phenotype and prolongs life span of mdx mice. / 08.2016 / PubMed / Full text

SIX5

Low Six4 and Six5 gene dosage improves dystrophic phenotype and prolongs life span of mdx mice. / 08.2016 / PubMed / Full text

SKAP2

Longevity-related molecular pathways are subject to midlife "switch" in humans. / 08.2019 / PubMed / Full text

SKI

Preventive effect of Shenkang injection against high glucose-induced senescence of renal tubular cells. / 04.2019 / PubMed / Full text

SKP1

Transcriptome profiling of postharvest strawberry fruit in response to exogenous auxin and abscisic acid. / 01.2016 / PubMed / Full text

SLAMF7

Age-related differences in neuroinflammatory responses associated with a distinct profile of regulatory markers on neonatal microglia. / 04.04.2014 / PubMed / Full text

SLC12A5

DNA methylation-based age prediction from saliva: High age predictability by combination of 7 CpG markers. / 07.2017 / PubMed / Full text

SLC15A1

Molecular changes to the rat renal cotransporters PEPT1 and PEPT2 due to ageing. / 02.2019 / PubMed / Full text

SLC15A2

Molecular changes to the rat renal cotransporters PEPT1 and PEPT2 due to ageing. / 02.2019 / PubMed / Full text

SLC16A7

Genetics of facial telangiectasia in the Rotterdam Study: a genome-wide association study and candidate gene approach. / 23.10.2020 / PubMed / Full text

SLC17A3

Sequencing of 2 subclinical atherosclerosis candidate regions in 3669 individuals: Cohorts for Heart and Aging Research in Genomic Epidemiology (CHARGE) Consortium Targeted Sequencing Study. / 06.2014 / PubMed / Full text

SLC17A4

Sequencing of 2 subclinical atherosclerosis candidate regions in 3669 individuals: Cohorts for Heart and Aging Research in Genomic Epidemiology (CHARGE) Consortium Targeted Sequencing Study. / 06.2014 / PubMed / Full text

SLC1A5

SLC1A5 glutamine transporter is a target of MYC and mediates reduced mTORC1 signaling and increased fatty acid oxidation in long-lived Myc hypomorphic mice. / 06.2019 / PubMed / Full text

SLC22A14

Explorative results from multistep screening for potential genetic risk loci of Alzheimer's disease in the longitudinal VITA study cohort. / 01.2018 / PubMed / Full text

SLC22A23

Clinical and genetic risk factors for decreased bone mineral density in Japanese patients with inflammatory bowel disease. / 11.2018 / PubMed / Full text

SLC24A5

[A question of colour]. / 01.2018 / PubMed / Full text

SLC25A1

The hyperornithinemia-hyperammonemia-homocitrullinuria syndrome. / 11.03.2015 / PubMed / Full text

SLC25A15

The hyperornithinemia-hyperammonemia-homocitrullinuria syndrome. / 11.03.2015 / PubMed / Full text

SLC26A2

Phenotypic characterization of Slc26a2 mutant mice reveals a multifactorial etiology of spondylolysis. / 01.2020 / PubMed / Full text

SLC27A1

EPRS is a critical mTORC1-S6K1 effector that influences adiposity in mice. / 16.02.2017 / PubMed / Full text

SLC2A4

Therapeutic and preventive effects of exercise on cardiometabolic parameters in aging and obese rats. / 02.2019 / PubMed / Full text

SLC2A4RG

Genome-wide association study for lactation persistency, female fertility, longevity, and lifetime profit index traits in Holstein dairy cattle. / 02.2017 / PubMed / Full text

SLC2A9

MicroRNA-Based Linkage between Aging and Cancer: from Epigenetics View Point. / 07-09.2016 / PubMed / Full text

SLC30A1

Changes in Zn homeostasis during long term culture of primary endothelial cells and effects of Zn on endothelial cell senescence. / 01.12.2017 / PubMed / Full text

SLC30A10

Changes in Zn homeostasis during long term culture of primary endothelial cells and effects of Zn on endothelial cell senescence. / 01.12.2017 / PubMed / Full text

SLC30A3

SLC30A3 and SEP15 gene polymorphisms influence the serum concentrations of zinc and selenium in mature adults. / 09.2014 / PubMed / Full text

SLC30A5

Changes in Zn homeostasis during long term culture of primary endothelial cells and effects of Zn on endothelial cell senescence. / 01.12.2017 / PubMed / Full text

SLC36A4

The amino acid transporter SLC36A4 regulates the amino acid pool in retinal pigmented epithelial cells and mediates the mechanistic target of rapamycin, complex 1 signaling. / 04.2017 / PubMed / Full text

SLC39A6

Changes in Zn homeostasis during long term culture of primary endothelial cells and effects of Zn on endothelial cell senescence. / 01.12.2017 / PubMed / Full text

SLC41A1

Magnesium transporter protein solute carrier family 41 member 1 suppresses human pancreatic ductal adenocarcinoma through magnesium-dependent Akt/mTOR inhibition and bax-associated mitochondrial apoptosis. / 08.05.2019 / PubMed / Full text

SLC52A2

Clinical, pathological and functional characterization of riboflavin-responsive neuropathy. / 01.11.2017 / PubMed / Full text

SLC52A3

Clinical, pathological and functional characterization of riboflavin-responsive neuropathy. / 01.11.2017 / PubMed / Full text

SLCO1B3

Paclitaxel-induced sensory peripheral neuropathy is associated with an ABCB1 single nucleotide polymorphism and older age in Japanese. / 06.2017 / PubMed / Full text

SLCO1C1

Genomics and CSF analyses implicate thyroid hormone in hippocampal sclerosis of aging. / 12.2016 / PubMed / Full text

SLIT2

Analysis of gene expression during aging of CGNs in culture: implication of SLIT2 and NPY in senescence. / 06.2015 / PubMed / Full text

SLPI

Human buccal epithelium acquires microbial hyporesponsiveness at birth, a role for secretory leukocyte protease inhibitor. / 06.2015 / PubMed / Full text

SMAP

DNA integrity-protecting and survival-promoting activity of serotonergic system in sturgeon juveniles and sazans. / 08.2017 / PubMed / Full text

SMARCA4

GBM-associated mutations and altered protein expression are more common in young patients. / 25.10.2016 / PubMed / Full text

SMARCA5

The epigenetic regulator SIRT7 guards against mammalian cellular senescence induced by ribosomal DNA instability. / 13.07.2018 / PubMed / Full text

SMARCB1

High-Throughput Functional Genetic and Compound Screens Identify Targets for Senescence Induction in Cancer. / 17.10.2017 / PubMed / Full text

SMARCD1

Delphinidin-3-glucoside suppresses lipid accumulation in HepG2 cells. / 12.2018 / PubMed / Full text

SMC1A

Age-related decrease of meiotic cohesins in human oocytes. / 2014 / PubMed / Full text

SMC1B

Age-related decrease of meiotic cohesins in human oocytes. / 2014 / PubMed / Full text

SMC2

The proteomic study of serially passaged human skin fibroblast cells uncovers down-regulation of the chromosome condensin complex proteins involved in replicative senescence. / 10.11.2018 / PubMed / Full text

SMC4

The proteomic study of serially passaged human skin fibroblast cells uncovers down-regulation of the chromosome condensin complex proteins involved in replicative senescence. / 10.11.2018 / PubMed / Full text

SMC5

SMC5/6 is required for the formation of segregation-competent bivalent chromosomes during meiosis I in mouse oocytes. / 01.05.2017 / PubMed / Full text

SMG6

Genetic Burden Analyses of Phenotypes Relevant to Aging in the Berlin Aging Study II (BASE-II). / 2016 / PubMed / Full text

SMPD1

Alterations in Lipid Profile of the Aging Kidney Identified by MALDI Imaging Mass Spectrometry. / 05.07.2019 / PubMed / Full text

SMURF2

Genome wide association and linkage analyses identified three loci-4q25, 17q23.2, and 10q11.21-associated with variation in leukocyte telomere length: the Long Life Family Study. / 2013 / PubMed / Full text

SMYD2

Collaboration of MYC and RUNX2 in lymphoma simulates T-cell receptor signaling and attenuates p53 pathway activity. / 10.2019 / PubMed / Full text

SNAI2

Reawakening of dormant estrogen-dependent human breast cancer cells by bone marrow stroma secretory senescence. / 17.08.2018 / PubMed / Full text

SNAP23

Effects of immobilization and aerobic training on proteins related to intramuscular substrate storage and metabolism in young and older men. / 03.2016 / PubMed / Full text

SND1

[Downregulation of SND1 Expression Accelerates Cell Senescence of Human Diploid Fibroblasts 2BS via Modulating the SASP]. / 05.2020 / PubMed / Full text

SNN

Evolving Spiking Neural Networks for Recognition of Aged Voices. / 01.2017 / PubMed / Full text

SNX15

SNX15 Regulates Cell Surface Recycling of APP and Aβ Generation. / 08.2016 / PubMed / Full text

SOBP

Lifetime increased cancer risk in mice following exposure to clinical proton beam-generated neutrons. / 01.05.2014 / PubMed / Full text

SORCS2

Genomewide meta-analysis identifies loci associated with IGF-I and IGFBP-3 levels with impact on age-related traits. / 10.2016 / PubMed / Full text

SORT1

Soluble sortilin is present in excess and positively correlates with progranulin in CSF of aging individuals. / 11.2016 / PubMed / Full text

SOS1

Fucoidan⁻Fucoxanthin Ameliorated Cardiac Function via IRS1/GRB2/ SOS1, GSK3β/CREB Pathways and Metabolic Pathways in Senescent Mice. / 21.01.2019 / PubMed / Full text

SOX10

SOX10 Distinguishes Pilocytic and Pilomyxoid Astrocytomas From Ependymomas but Shows No Differences in Expression Level in Ependymomas From Infants Versus Older Children or Among Molecular Subgroups. / 04.2016 / PubMed / Full text

SOX11

A lowered 26S proteasome activity correlates with mantle lymphoma cell lines resistance to genotoxic stress. / 10.08.2017 / PubMed / Full text

SOX13

In silico analysis of human renin gene-gene interactions and neighborhood topologically associated domains suggests breakdown of insulators contribute to ageing-associated diseases. / 12.2019 / PubMed / Full text

SOX17

SOX17 Regulates Conversion of Human Fibroblasts Into Endothelial Cells and Erythroblasts by Dedifferentiation Into CD34 Progenitor Cells. / 20.06.2017 / PubMed / Full text

SP2

Influence of season, age and management on scrotal thermal profile in Murrah bulls using scrotal infrared digital thermography. / 12.2017 / PubMed / Full text

SP3

A genome-wide scan reveals important roles of DNA methylation in human longevity by regulating age-related disease genes. / 2015 / PubMed / Full text

SP5

Novel 5-HT5A receptor antagonists ameliorate scopolamine-induced working memory deficit in mice and reference memory impairment in aged rats. / 03.2015 / PubMed / Full text

SP7

microRNA-31 inhibition partially ameliorates the deficiency of bone marrow stromal cells from cleidocranial dysplasia. / 06.2019 / PubMed / Full text

SP8

Molecular control of two novel migratory paths for CGE-derived interneurons in the developing mouse brain. / 15.05.2016 / PubMed / Full text

SPAG9

Sperm-associated antigen 9 (SPAG9) promotes the survival and tumor growth of triple-negative breast cancer cells. / 10.2016 / PubMed / Full text

SPATS2L

Longitudinal analysis of bronchodilator response in asthmatics and effect modification of age-related trends by genotype. / 02.2019 / PubMed / Full text

SPG21

Loss of Maspardin Attenuates the Growth and Maturation of Mouse Cortical Neurons. / 2016 / PubMed / Full text

SPG7

Loss of the Drosophila m-AAA mitochondrial protease paraplegin results in mitochondrial dysfunction, shortened lifespan, and neuronal and muscular degeneration. / 21.02.2018 / PubMed / Full text

SPHK1

Sphingosine Kinase-1 Is Essential for Maintaining External/Outer Limiting Membrane and Associated Adherens Junctions in the Aging Retina. / 10.2019 / PubMed / Full text

SPHK2

Loss of genomic integrity induced by lysosphingolipid imbalance drives ageing in the heart. / 04.2019 / PubMed / Full text

SPI1

Association of levels of fasting glucose and insulin with rare variants at the chromosome 11p11.2-MADD locus: Cohorts for Heart and Aging Research in Genomic Epidemiology (CHARGE) Consortium Targeted Sequencing Study. / 06.2014 / PubMed / Full text

SPN

[Identification of single nucleotide polymorphisms in centenarians]. / 05-06.2016 / PubMed / Full text

SPX

Phosphorus remobilization from rice flag leaves during grain filling: an RNA-seq study. / 01.2017 / PubMed / Full text

SRL

Income dividends and subjective survival in a Cherokee Indian cohort: a quasi-experiment. / 04-06.2020 / PubMed / Full text

SRPK1

[Age-related changes in the content of serine-arginine protein kinase 1 (SRPK1) in human dermis.] / 2017 / PubMed

SRSF1

Cellular stress and AMPK activation as a common mechanism of action linking the effects of metformin and diverse compounds that alleviate accelerated aging defects in Hutchinson-Gilford progeria syndrome. / 09.2018 / PubMed / Full text

SRSF10

Inflammation and hyperglycemia mediate Deaf1 splicing in the pancreatic lymph nodes via distinct pathways during type 1 diabetes. / 02.2015 / PubMed / Full text

SRSF2

Insight into the molecular pathophysiology of myelodysplastic syndromes: targets for novel therapy. / 10.2016 / PubMed / Full text

SRSF3

Alternative polyadenylation dependent function of splicing factor SRSF3 contributes to cellular senescence. / 04.03.2019 / PubMed / Full text

SSBP2

Genetic associations with age of menopause in familial longevity. / 10.2019 / PubMed / Full text

SSTR3

Type 3 Adenylyl Cyclase and Somatostatin Receptor 3 Expression Persists in Aged Rat Neocortical and Hippocampal Neuronal Cilia. / 2016 / PubMed / Full text

SSX2

Ectopic expression of cancer/testis antigen SSX2 induces DNA damage and promotes genomic instability. / 02.2015 / PubMed / Full text

ST18

[Target protein candidates of hypothalamus in aging rats with intervention by Qiongyugao]. / 04.2016 / PubMed / Full text

STAT4

RNA-Seq analysis reveals new evidence for inflammation-related changes in aged kidney. / 24.05.2016 / PubMed / Full text

STC1

Proteomic profiling of follicle fluids after superstimulation in one-month-old lambs. / 02.2018 / PubMed / Full text

STC2

Genome-wide Associations Reveal Human-Mouse Genetic Convergence and Modifiers of Myogenesis, CPNE1 and STC2. / 05.12.2019 / PubMed / Full text

STK11

A Multigene Test Could Cost-Effectively Help Extend Life Expectancy for Women at Risk of Hereditary Breast Cancer. / 04.2017 / PubMed / Full text

STK32C

DNA methylation analysis on purified neurons and glia dissects age and Alzheimer's disease-specific changes in the human cortex. / 25.07.2018 / PubMed / Full text

STK38L

[Role of PLAT, PKHD1L1, STK38L and TEAD1 genes Alu-polymorphism for longevity]. / 2016 / PubMed

STOML2

Slower Dynamics and Aged Mitochondria in Sporadic Alzheimer's Disease. / 2017 / PubMed / Full text

STRA6

Transport of vitamin A across blood-tissue barriers is facilitated by STRA6. / 08.2016 / PubMed / Full text

STX17

Directed elimination of senescent cells attenuates development of osteoarthritis by inhibition of c-IAP and XIAP. / 01.10.2019 / PubMed / Full text

SUCNR1

[The effect of Mexidol on cerebral mitochondriogenesis at a young age and during aging]. / 2020 / PubMed / Full text

SUGCT

Knockout of the non-essential gene SUGCT creates diet-linked, age-related microbiome disbalance with a diabetes-like metabolic syndrome phenotype. / 09.2020 / PubMed / Full text

SULT1A1

Bayesian association scan reveals loci associated with human lifespan and linked biomarkers. / 27.07.2017 / PubMed / Full text

SULT1E1

Sex- and age-dependent gene expression in human liver: An implication for drug-metabolizing enzymes. / 02.2017 / PubMed / Full text

SUMO1

SUMO1-conjugation is altered during normal aging but not by increased amyloid burden. / 08.2018 / PubMed / Full text

SUMO2

KSHV latent protein LANA2 inhibits sumo2 modification of p53. / 2015 / PubMed / Full text

SUN1

Imbalanced nucleocytoskeletal connections create common polarity defects in progeria and physiological aging. / 26.02.2019 / PubMed / Full text

SUN2

Imbalanced nucleocytoskeletal connections create common polarity defects in progeria and physiological aging. / 26.02.2019 / PubMed / Full text

SV2B

Mutant Huntingtin Causes a Selective Decrease in the Expression of Synaptic Vesicle Protein 2C. / 10.2018 / PubMed / Full text

SV2C

Mutant Huntingtin Causes a Selective Decrease in the Expression of Synaptic Vesicle Protein 2C. / 10.2018 / PubMed / Full text

SYCP2

Accelerated reproductive aging in females lacking a novel centromere protein [[SYCP2L]]. / 15.11.2015 / PubMed / Full text

SYCP2L

Accelerated reproductive aging in females lacking a novel centromere protein [[SYCP2L]]. / 15.11.2015 / PubMed / Full text

SYCP3

Effects of Saikokaryukotsuboreito on Spermatogenesis and Fertility in Aging Male Mice. / 05.04.2016 / PubMed / Full text

SYNE1

Nesprin-1 impact on tumorigenic cell phenotypes. / 02.2020 / PubMed / Full text

SYNJ2

DNA methylation analysis on purified neurons and glia dissects age and Alzheimer's disease-specific changes in the human cortex. / 25.07.2018 / PubMed / Full text

SYT1

Two Behavioral Tests Allow a Better Correlation Between Cognitive Function and Expression of Synaptic Proteins. / 2018 / PubMed / Full text

SYT4

Age-related obesity and type 2 diabetes dysregulate neuronal associated genes and proteins in humans. / 06.10.2015 / PubMed / Full text

SYT7

Synaptotagmin-7, a binding protein of P53, inhibits the senescence and promotes the tumorigenicity of lung cancer cells. / 28.02.2019 / PubMed / Full text

TAAR1

Minimal Age-Related Alterations in Behavioral and Hematological Parameters in Trace Amine-Associated Receptor 1 (TAAR1) Knockout Mice. / 03.2020 / PubMed / Full text

TAC3

Effects of Age and Estradiol on Gene Expression in the Rhesus Macaque Hypothalamus. / 2015 / PubMed / Full text

TACR3

Association of a neurokinin 3 receptor polymorphism with the anterior basal forebrain. / 06.2015 / PubMed / Full text

TAF15

FET proteins regulate lifespan and neuronal integrity. / 27.04.2016 / PubMed / Full text

TAF7

Basonuclin 1 deficiency causes testicular premature aging: BNC1 cooperates with TAF7L to regulate spermatogenesis. / 22.01.2020 / PubMed / Full text

TAF7L

Basonuclin 1 deficiency causes testicular premature aging: BNC1 cooperates with TAF7L to regulate spermatogenesis. / 22.01.2020 / PubMed / Full text

TAP2

Lifespan of mice and primates correlates with immunoproteasome expression. / 05.2015 / PubMed / Full text

TAS1R2

Bitter, Sweet, Salty, Sour and Umami Taste Perception Decreases with Age: Sex-Specific Analysis, Modulation by Genetic Variants and Taste-Preference Associations in 18 to 80 Year-Old Subjects. / 18.10.2018 / PubMed / Full text

TBC1D4

Effects of Exercise Training on Regulation of Skeletal Muscle Glucose Metabolism in Elderly Men. / 07.2015 / PubMed / Full text

TBR1

DNA methylation-based age prediction from saliva: High age predictability by combination of 7 CpG markers. / 07.2017 / PubMed / Full text

TBX21

[Study of gene expression of transcription factors T cells during aging]. / 2015 / PubMed

TBX3

Coordinated control of senescence by lncRNA and a novel T-box3 co-repressor complex. / 29.05.2014 / PubMed / Full text

TCERG1

The longevity-promoting factor, TCER-1, widely represses stress resistance and innate immunity. / 17.07.2019 / PubMed / Full text

TCF15

Loss of Neurogenesis in Aging Hydra. / 05.2019 / PubMed / Full text

TCF21

Balance between senescence and apoptosis is regulated by telomere damage-induced association between p16 and caspase-3. / 22.06.2018 / PubMed / Full text

TCF4

Genome-Wide Association Analysis of the Sense of Smell in U.S. Older Adults: Identification of Novel Risk Loci in African-Americans and European-Americans. / 12.2017 / PubMed / Full text

TCF7L1

TCF7L1 promotes skin tumorigenesis independently of β-catenin through induction of LCN2. / 03.05.2017 / PubMed / Full text

TCTA

Exciplex-Forming Cohost for High Efficiency and High Stability Phosphorescent Organic Light-Emitting Diodes. / 17.01.2018 / PubMed / Full text

TDRD7

RNA granule component TDRD7 gene polymorphisms in a Han Chinese population with age-related cataract. / 02.2014 / PubMed / Full text

TECPR2

Neuropathology-driven Whole-genome Sequencing Study Points to Novel Candidate Genes for Healthy Brain Aging. / 01-03.2019 / PubMed / Full text

TEF

Expression of human HSP27 in yeast extends replicative lifespan and uncovers a hormetic response. / 10.2020 / PubMed / Full text

TEN1

Stimulation of cell proliferation by glutathione monoethyl ester in aged bone marrow stromal cells is associated with the assistance of TERT gene expression and telomerase activity. / 08.2016 / PubMed / Full text

TEP1

[Influence of Age on the Susceptibility of Anopheles stephensi to Plasmodium berghei Infection]. / 12.2016 / PubMed

TFAP2A

Replicative senescence is associated with nuclear reorganization and with DNA methylation at specific transcription factor binding sites. / 2015 / PubMed / Full text

TFPI

Identification of cardiovascular health gene variants related to longevity in a Chinese population. / 07.09.2020 / PubMed / Full text

TGDS

The evaluation and design of a short depression screening tool in Turkish older adults. / 10.2018 / PubMed / Full text

TGFB2

Seminal plasma transforming growth factor-β, activin A and follistatin fluctuate within men over time. / 10.2016 / PubMed / Full text

TGFB3

Seminal plasma transforming growth factor-β, activin A and follistatin fluctuate within men over time. / 10.2016 / PubMed / Full text

TGFBR1

Dexamethasone Induces a Specific Form of Ramified Dysfunctional Microglia. / 02.2019 / PubMed / Full text

TGFBR2

TGF-β type 2 receptor-mediated modulation of the IL-36 family can be therapeutically targeted in osteoarthritis. / 08.05.2019 / PubMed / Full text

TGM2

Towards frailty biomarkers: Candidates from genes and pathways regulated in aging and age-related diseases. / 11.2018 / PubMed / Full text

THADA

Causal mechanisms and balancing selection inferred from genetic associations with polycystic ovary syndrome. / 29.09.2015 / PubMed / Full text

THBS1

G protein-coupled receptor kinase 4-induced cellular senescence and its senescence-associated gene expression profiling. / 15.11.2017 / PubMed / Full text

THBS4

Specific factors in blood from young but not old mice directly promote synapse formation and NMDA-receptor recruitment. / 18.06.2019 / PubMed / Full text

THEMIS

Lifetime benefits of early detection and treatment of diabetic kidney disease. / 2019 / PubMed / Full text

THPO

Thrombopoietin is associated with δ's intercept, and only in Non-Hispanic Whites. / 2016 / PubMed / Full text

TINF2

Acute telomerase components depletion triggers oxidative stress as an early event previous to telomeric shortening. / 04.2018 / PubMed / Full text

TJP1

Morphological and immunohistochemical characteristics of the equine corneal epithelium. / 11.2019 / PubMed / Full text

TLR6

Decreased NLRP3 inflammasome expression in aged lung may contribute to increased susceptibility to secondary Streptococcus pneumoniae infection. / 05.2018 / PubMed / Full text

TM9SF1

Epigallocatechin-3-gallate increases autophagy signaling in resting and unloaded plantaris muscles but selectively suppresses autophagy protein abundance in reloaded muscles of aged rats. / 06.2017 / PubMed / Full text

TMEM135

Mouse [i]Tmem135[/i] mutation reveals a mechanism involving mitochondrial dynamics that leads to age-dependent retinal pathologies. / 15.11.2016 / PubMed / Full text

TMEM18

Sequence variation in TMEM18 in association with body mass index: Cohorts for Heart and Aging Research in Genomic Epidemiology (CHARGE) Consortium Targeted Sequencing Study. / 06.2014 / PubMed / Full text

TMEM51

Genome-wide analysis of DNA methylation profiles in a senescence-accelerated mouse prone 8 brain using whole-genome bisulfite sequencing. / 01.06.2017 / PubMed / Full text

TNFRSF11B

Genetic Burden Analyses of Phenotypes Relevant to Aging in the Berlin Aging Study II (BASE-II). / 2016 / PubMed / Full text

TNFRSF1A

Consumption of protein-enriched milk has minor effects on inflammation in older adults-A 12-week double-blind randomized controlled trial. / 03.2017 / PubMed / Full text

TNFSF10

Role of mitochondrial function in cell death and body metabolism. / 01.06.2016 / PubMed / Full text

TNFSF13

Genome-wide methylation analysis reveals differentially methylated loci that are associated with an age-dependent increase in bovine fibroblast response to LPS. / 25.05.2017 / PubMed / Full text

TNFSF15

Expression of pro- and anti-inflammatory cytokines and chemokines during the ovulatory cycle and effects of aging on their expression in the uterine mucosa of laying hens. / 11.2018 / PubMed / Full text

TNK1

Role of CLU, PICALM, and TNK1 Genotypes in Aging With and Without Alzheimer's Disease. / 05.2018 / PubMed / Full text

TNNI1

Regular aerobic exercise-ameliorated troponin I carbonylation to mitigate aged rat soleus muscle functional recession. / 05.2019 / PubMed / Full text

TNNT1

Improved knee extensor strength with resistance training associates with muscle specific miRNAs in older adults. / 02.2015 / PubMed / Full text

TNP1

Cytological and molecular aspects of the ageing sperm. / 01.02.2019 / PubMed / Full text

TNP2

Cytological and molecular aspects of the ageing sperm. / 01.02.2019 / PubMed / Full text

TNPO3

Genetic associations with age of menopause in familial longevity. / 10.2019 / PubMed / Full text

TNS3

Genomewide meta-analysis identifies loci associated with IGF-I and IGFBP-3 levels with impact on age-related traits. / 10.2016 / PubMed / Full text

TOR2A

The correlation of copy number variations with longevity in a genome-wide association study of Han Chinese. / 05.06.2018 / PubMed / Full text

TP53BP1

Induction of DNA double-strand breaks and cellular senescence by human respiratory syncytial virus. / 18.05.2016 / PubMed / Full text

TP53INP1

TP53INP1 deficiency maintains murine B lymphopoiesis in aged bone marrow through redox-controlled IL-7R/STAT5 signaling. / 02.01.2019 / PubMed / Full text

TP53RK

Novel homozygous OSGEP gene pathogenic variants in two unrelated patients with Galloway-Mowat syndrome: case report and review of the literature. / 11.04.2019 / PubMed / Full text

TP73

G protein-coupled receptor kinase 4-induced cellular senescence and its senescence-associated gene expression profiling. / 15.11.2017 / PubMed / Full text

TPP2

Early-onset Evans syndrome, immunodeficiency, and premature immunosenescence associated with tripeptidyl-peptidase II deficiency. / 29.01.2015 / PubMed / Full text

TPRKB

Novel homozygous OSGEP gene pathogenic variants in two unrelated patients with Galloway-Mowat syndrome: case report and review of the literature. / 11.04.2019 / PubMed / Full text

TPX2

Targeting DTL induces cell cycle arrest and senescence and suppresses cell growth and colony formation through TPX2 inhibition in human hepatocellular carcinoma cells. / 2018 / PubMed / Full text

TRADD

TNF/TNFR₁ pathway and endoplasmic reticulum stress are involved in ofloxacin-induced apoptosis of juvenile canine chondrocytes. / 15.04.2014 / PubMed / Full text

TRAF6

Elevated A20 contributes to age-dependent macrophage dysfunction in the lungs. / 06.2014 / PubMed / Full text

TRAV1-2

Human blood MAIT cell subsets defined using MR1 tetramers. / 05.2018 / PubMed / Full text

TRAV27

Perturbed CD8 T cell immunity across universal influenza epitopes in the elderly. / 02.2018 / PubMed / Full text

TRBV19

Perturbed CD8 T cell immunity across universal influenza epitopes in the elderly. / 02.2018 / PubMed / Full text

TREM1

A TREM1 variant alters the accumulation of Alzheimer-related amyloid pathology. / 03.2015 / PubMed / Full text

TRIB2

TRIB2 functions as novel oncogene in colorectal cancer by blocking cellular senescence through AP4/p21 signaling. / 12.12.2018 / PubMed / Full text

TRIB3

Inhibition of glioma growth by flavokawain B is mediated through endoplasmic reticulum stress induced autophagy. / 2018 / PubMed / Full text

TRIM21

TRIM21 overexpression promotes tumor progression by regulating cell proliferation, cell migration and cell senescence in human glioma. / 2020 / PubMed / Full text

TRIM27

TRIM27 Functions as a Novel Oncogene in Non-Triple-Negative Breast Cancer by Blocking Cellular Senescence through p21 Ubiquitination. / 04.12.2020 / PubMed / Full text

TRIOBP

A Large Genome-Wide Association Study of Age-Related Hearing Impairment Using Electronic Health Records. / 10.2016 / PubMed / Full text

TRO

Post-mortem findings and piglet mortality in relation to strategic use of straw at farrowing. / 01.05.2015 / PubMed / Full text

TRPC1

Ca entry via TRPC1 is essential for cellular differentiation and modulates secretion via the SNARE complex. / 01.07.2019 / PubMed / Full text

TRPC7

Nociceptive transient receptor potential canonical 7 (TRPC7) mediates aging-associated tumorigenesis induced by ultraviolet B. / 01.2020 / PubMed / Full text

TRPM5

Genetic strategies to analyze primary TRP channel-expressing cells in mice. / 11.2017 / PubMed / Full text

TRPS1

miRNA expression profiling uncovers a role of miR-302b-3p in regulating skin fibroblasts senescence. / 01.2020 / PubMed / Full text

TRPV2

The role of transient receptor potential vanilloid 2 channel in cardiac aging. / 10.2017 / PubMed / Full text

TSG101

Exosomal Notch3 from high glucose-stimulated endothelial cells regulates vascular smooth muscle cells calcification/aging. / 01.09.2019 / PubMed / Full text

TSHR

TSH-independent release of thyroid hormones through cold exposure in aging rats. / 27.10.2017 / PubMed / Full text

TSPYL5

Uncovering genetic mechanisms of kidney aging through transcriptomics, genomics, and epigenomics. / 03.2019 / PubMed / Full text

TSSK6

DNA methylation-based age prediction from saliva: High age predictability by combination of 7 CpG markers. / 07.2017 / PubMed / Full text

TWIST2

DNA methylation abnormalities at gene promoters are extensive and variable in the elderly and phenocopy cancer cells. / 07.2014 / PubMed / Full text

TXK

Phenotypic characteristics of aged CD4 CD28 T lymphocytes are determined by changes in the whole-genome DNA methylation pattern. / 04.2017 / PubMed / Full text

TXN

Thioredoxin mitigates radiation-induced hematopoietic stem cell injury in mice. / 15.11.2017 / PubMed / Full text

TXNDC5

Genetic associations with age of menopause in familial longevity. / 10.2019 / PubMed / Full text

TXNRD3

Mitochondrial thioredoxin reductase 2 is elevated in long-lived primate as well as rodent species and extends fly mean lifespan. / 08.2017 / PubMed / Full text

TYK2

Immunologic effects of chronic administration of tofacitinib, a Janus kinase inhibitor, in cynomolgus monkeys and rats - Comparison of juvenile and adult responses. / 04.2018 / PubMed / Full text

TYMS

C. elegans lifespan extension by osmotic stress requires FUdR, base excision repair, FOXO, and sirtuins. / 03.2016 / PubMed / Full text

TYRO3

The tyrosine kinase receptor Tyro3 enhances lifespan and neuropeptide Y (Npy) neuron survival in the mouse anorexia ([i]anx[/i]) mutation. / 01.05.2017 / PubMed / Full text

UACA

Knockdown of [i]UACA[/i] inhibitsproliferation and invasion and promotes senescence of hepatocellular carcinoma cells. / 2018 / PubMed / Full text

UAP1

Functional inactivation of UDP-N-acetylglucosamine pyrophosphorylase 1 (UAP1) induces early leaf senescence and defence responses in rice. / 02.2015 / PubMed / Full text

UBC

Selection of a Real-Time PCR Housekeeping Gene Panel in Human Endothelial Colony Forming Cells for Cellular Senescence Studies. / 2019 / PubMed / Full text

UBE2D2

Stable reference genes in granulosa cells of bovine dominant follicles during follicular growth, FSH stimulation and maternal aging. / 04.2016 / PubMed / Full text

UBE2E3

Loss of the ubiquitin conjugating enzyme UBE2E3 induces cellular senescence. / 07.2018 / PubMed / Full text

UBE2N

Aged monkey brains reveal the role of ubiquitin-conjugating enzyme UBE2N in the synaptosomal accumulation of mutant huntingtin. / 01.03.2015 / PubMed / Full text

UBE4B

CircRNAs in the tree shrew ([i]Tupaia belangeri[/i]) brain during postnatal development and aging. / 30.04.2018 / PubMed / Full text

UBN1

O-linked N-acetylglucosamine transferase (OGT) interacts with the histone chaperone HIRA complex and regulates nucleosome assembly and cellular senescence. / 07.06.2016 / PubMed / Full text

UBP1

Expression of potato RNA-binding proteins StUBA2a/b and StUBA2c induces hypersensitive-like cell death and early leaf senescence in Arabidopsis. / 07.2015 / PubMed / Full text

UBQLN2

Frontotemporal dementia: insights into the biological underpinnings of disease through gene co-expression network analysis. / 24.02.2016 / PubMed / Full text

UBTD1

UBTD1 induces cellular senescence through an UBTD1-Mdm2/p53 positive feedback loop. / 03.2015 / PubMed / Full text

UBTF

Age-associated dysregulation of protein metabolism in the mammalian oocyte. / 12.2017 / PubMed / Full text

UCHL3

UCHL3 Regulates Topoisomerase-Induced Chromosomal Break Repair by Controlling TDP1 Proteostasis. / 12.06.2018 / PubMed / Full text

UCHL5

Amelioration of neuronal cell death in a spontaneous obese rat model by dietary restriction through modulation of ubiquitin proteasome system. / 07.2016 / PubMed / Full text

UCN

Novel molecular mechanisms for the adaptogenic effects of herbal extracts on isolated brain cells using systems biology. / 15.11.2018 / PubMed / Full text

UCN3

Urocortin 3 signalling in the auditory brainstem aids recovery of hearing after reversible noise-induced threshold shift. / 08.2019 / PubMed / Full text

UGT1A6

Expression of UDP-Glucuronosyltransferase 1 (UGT1) and Glucuronidation Activity toward Endogenous Substances in Humanized UGT1 Mouse Brain. / 07.2015 / PubMed / Full text

UGT2B28

Ages of hepatocellular carcinoma occurrence and life expectancy are associated with a UGT2B28 genomic variation. / 05.12.2019 / PubMed / Full text

UGT2B7

Application of a physiologically based pharmacokinetic model for the prediction of mirabegron plasma concentrations in a population with severe renal impairment. / 05.2019 / PubMed / Full text

ULK2

miR-26a suppresses autophagy in swine Sertoli cells by targeting ULK2. / 08.2018 / PubMed / Full text

UNC5C

Identification of genes associated with dissociation of cognitive performance and neuropathological burden: Multistep analysis of genetic, epigenetic, and transcriptional data. / 04.2017 / PubMed / Full text

UPF1

Differential alternative splicing coupled to nonsense-mediated decay of mRNA ensures dietary restriction-induced longevity. / 21.08.2017 / PubMed / Full text

UPRT

UPRT, a suicide-gene therapy candidate in higher eukaryotes, is required for Drosophila larval growth and normal adult lifespan. / 14.08.2015 / PubMed / Full text

UQCRC1

Effect of testosterone on markers of mitochondrial oxidative phosphorylation and lipid metabolism in muscle of aging men with subnormal bioavailable testosterone. / 07.2014 / PubMed / Full text

UQCRFS1

Contribution of genetic polymorphisms on functional status at very old age: a gene-based analysis of 38 genes (311 SNPs) in the oxidative stress pathway. / 04.2014 / PubMed / Full text

USF1

The rs2516839 variation of USF1 gene is associated with 4-year mortality of nonagenarian women: The Vitality 90 study. / 01.2019 / PubMed / Full text

USF2

Age-Related Expression of Human AT1R Variants and Associated Renal Dysfunction in Transgenic Mice. / 15.10.2018 / PubMed / Full text

USP10

Long noncoding RNA H19 mediates melatonin inhibition of premature senescence of c-kit( ) cardiac progenitor cells by promoting miR-675. / 08.2016 / PubMed / Full text

USP14

Low expression of aging-related [[NRXN3]] is associated with Alzheimer disease: A systematic review and meta-analysis. / 07.2018 / PubMed / Full text

USP15

Deficiency of parkin and PINK1 impairs age-dependent mitophagy in [i]Drosophila[/i]. / 29.05.2018 / PubMed / Full text

USP28

Genetic interrogation of replicative senescence uncovers a dual role for USP28 in coordinating the p53 and GATA4 branches of the senescence program. / 01.10.2017 / PubMed / Full text

USP30

Deficiency of parkin and PINK1 impairs age-dependent mitophagy in [i]Drosophila[/i]. / 29.05.2018 / PubMed / Full text

USP4

Increased Expression of Ubiquitin-Specific Protease 4 Participates in Neuronal Apoptosis After Intracerebral Hemorrhage in Adult Rats. / 04.2017 / PubMed / Full text

USP8

Inhibition of the deubiquitinase USP8 corrects a Drosophila PINK1 model of mitochondria dysfunction. / 04.2019 / PubMed / Full text

UTF1

miR-377 induces senescence in human skin fibroblasts by targeting DNA methyltransferase 1. / 09.03.2017 / PubMed / Full text

UVSSA

A C. elegans homolog for the UV-hypersensitivity syndrome disease gene UVSSA. / 05.2016 / PubMed / Full text

VAMP2

Newly produced synaptic vesicle proteins are preferentially used in synaptic transmission. / 01.08.2018 / PubMed / Full text

VAMP8

NUPR1 maintains autolysosomal efflux by activating SNAP25 transcription in cancer cells. / 2018 / PubMed / Full text

VAPB

Transforming Cytosolic Proteins into "Insoluble" and Membrane-toxic Forms Triggering Diseases/Aging by Genetic, Pathological or Environmental Factors. / 2017 / PubMed / Full text

VAV3

Age-related obesity and type 2 diabetes dysregulate neuronal associated genes and proteins in humans. / 06.10.2015 / PubMed / Full text

VCL

The effects of different preservation methods on ide (Leuciscus idus) sperm and the longevity of sperm movement. / 04.2018 / PubMed / Full text

VDAC3

VDAC3 As a Potential Marker of Mitochondrial Status Is Involved in Cancer and Pathology. / 2016 / PubMed / Full text

VEGFC

Proteomic profiling of follicle fluids after superstimulation in one-month-old lambs. / 02.2018 / PubMed / Full text

VEGFD

Single-Arm Resistance Training Study to Determine the Relationship between Training Outcomes and Muscle Growth Factor mRNAs in Older Adults Consuming Numerous Medications and Supplements. / 2018 / PubMed / Full text

VHLL

The Monetary Valuation of Lifetime Health Improvement and Life Expectancy Gains in Turkey. / 29.09.2017 / PubMed / Full text

VIPR2

Novel molecular mechanisms for the adaptogenic effects of herbal extracts on isolated brain cells using systems biology. / 15.11.2018 / PubMed / Full text

VPREB3

Age-related but not longevity-related genes are found by weighted gene co-expression network analysis in the peripheral blood cells of humans. / 19.01.2019 / PubMed / Full text

VPS13C

SerThr-PhosphoProteome of Brain from Aged PINK1-KO A53T-SNCA Mice Reveals pT1928-MAP1B and pS3781-ANK2 Deficits, as Hub between Autophagy and Synapse Changes. / 04.07.2019 / PubMed / Full text

VPS13D

SerThr-PhosphoProteome of Brain from Aged PINK1-KO A53T-SNCA Mice Reveals pT1928-MAP1B and pS3781-ANK2 Deficits, as Hub between Autophagy and Synapse Changes. / 04.07.2019 / PubMed / Full text

VPS26A

Characterization of novel markers of senescence and their prognostic potential in cancer. / 20.11.2014 / PubMed / Full text

VPS37B

Identification of HIV infection-related DNA methylation sites and advanced epigenetic aging in HIV-positive, treatment-naive U.S. veterans. / 20.02.2017 / PubMed / Full text

VSIG4

Immune checkpoint protein VSIG4 as a biomarker of aging in murine adipose tissue. / 10.2020 / PubMed / Full text

VSX1

Amyloid Precursor-Like Protein 2 deletion-induced retinal synaptopathy related to congenital stationary night blindness: structural, functional and molecular characteristics. / 08.06.2016 / PubMed / Full text

WASL

Loss of Wasl improves pancreatic cancer outcome. / 21.05.2020 / PubMed / Full text

WDR48

Genome-wide studies of verbal declarative memory in nondemented older people: the Cohorts for Heart and Aging Research in Genomic Epidemiology consortium. / 15.04.2015 / PubMed / Full text

WDR5

Inhibition of the H3K4 methyltransferase MLL1/WDR5 complex attenuates renal senescence in ischemia reperfusion mice by reduction of p16 . / 11.2019 / PubMed / Full text

WDR73

Novel homozygous OSGEP gene pathogenic variants in two unrelated patients with Galloway-Mowat syndrome: case report and review of the literature. / 11.04.2019 / PubMed / Full text

WDSUB1

The complex genetics of gait speed: genome-wide meta-analysis approach. / 10.01.2017 / PubMed / Full text

WFDC2

Differences in biomarkers and molecular pathways according to age for patients with HFrEF. / 01.10.2020 / PubMed / Full text

WIF1

Identification of the mechanisms by which age alters the mechanosensitivity of mesenchymal stromal cells on substrates of differing stiffness: Implications for osteogenesis and angiogenesis. / 15.04.2017 / PubMed / Full text

WNK1

Overexpression of WNK1 in POMC-expressing neurons reduces weigh gain via WNK4-mediated degradation of Kir6.2. / 10.2018 / PubMed / Full text

WNK4

Overexpression of WNK1 in POMC-expressing neurons reduces weigh gain via WNK4-mediated degradation of Kir6.2. / 10.2018 / PubMed / Full text

WNT10A

Dysregulation of the Wnt Signaling Pathway and Synovial Stem Cell Dysfunction in Osteoarthritis Development. / 01.04.2020 / PubMed / Full text

WNT3

Role of CD133 Molecule in Wnt Response and Renal Repair. / 03.2018 / PubMed / Full text

WNT7A

Exogenous Expression of WNT7A in Leukemia-Derived Cell Lines Induces Resistance to Chemotherapeutic Agents. / 2020 / PubMed / Full text

XAF1

XIAP-associating factor 1, a transcriptional target of BRD7, contributes to endothelial cell senescence. / 02.02.2016 / PubMed / Full text

XCL1

Cathelicidin related antimicrobial peptide, laminin, Toll-like receptors and chemokines levels in experimental hypersensitivity pneumonitis in mice. / 06.2015 / PubMed / Full text

XG

The effect of administration media on palatability and ease of swallowing of multiparticulate formulations. / 15.11.2018 / PubMed / Full text

XK

Neurodegeneration in the elderly - When the blood type matters: An overview of the McLeod syndrome with focus on hematological features. / 06.2015 / PubMed / Full text

XPO1

Nuclear Export Inhibition Enhances HLH-30/TFEB Activity, Autophagy, and Lifespan. / 15.05.2018 / PubMed / Full text

YBX2

Preovulatory Aging In Vivo and In Vitro Affects Maturation Rates, Abundance of Selected Proteins, Histone Methylation Pattern and Spindle Integrity in Murine Oocytes. / 2016 / PubMed / Full text

YES1

Re-exploring the core genes and modules in the human frontal cortex during chronological aging: insights from network-based analysis of transcriptomic studies. / 20.10.2018 / PubMed / Full text

YY1

Low mitochondrial DNA content associates with familial longevity: the Leiden Longevity Study. / 06.2014 / PubMed / Full text

ZAP70

Increased ZAP70 Is Involved in Dry Skin Pruritus in Aged Mice. / 2016 / PubMed / Full text

ZBED6

Correlation between ZBED6 Gene Upstream CpG Island methylation and mRNA expression in cattle. / 03.04.2017 / PubMed / Full text

ZFHX3

Shift work, DNA methylation and epigenetic age. / 01.10.2019 / PubMed / Full text

ZFP36L1

Zinc finger protein ZFP36L1 promotes osteoblastic differentiation but represses adipogenic differentiation of mouse multipotent cells. / 28.03.2017 / PubMed / Full text

ZFPM2

Novel molecular mechanisms for the adaptogenic effects of herbal extracts on isolated brain cells using systems biology. / 15.11.2018 / PubMed / Full text

ZNF14

Cell senescence abrogates the therapeutic potential of human mesenchymal stem cells in the lethal endotoxemia model. / 07.2014 / PubMed / Full text

ZNF207

Proteomics and metabolomics identify molecular mechanisms of aging potentially predisposing for chronic lymphocytic leukemia. / 02.2018 / PubMed / Full text

ZNF367

RNA-seq of the aging brain in the short-lived fish N. furzeri - conserved pathways and novel genes associated with neurogenesis. / 12.2014 / PubMed / Full text

ZNF396

Novel molecular mechanisms for the adaptogenic effects of herbal extracts on isolated brain cells using systems biology. / 15.11.2018 / PubMed / Full text

ZNF467

Novel molecular mechanisms for the adaptogenic effects of herbal extracts on isolated brain cells using systems biology. / 15.11.2018 / PubMed / Full text

ZNF616

Global Characteristics of CSIG-Associated Gene Expression Changes in Human HEK293 Cells and the Implications for CSIG Regulating Cell Proliferation and Senescence. / 2015 / PubMed / Full text

ZNF704

Genome-Wide Association Study and Linkage Analysis of the Healthy Aging Index. / 08.2015 / PubMed / Full text

ZP2

Melatonin improves the fertilization ability of post-ovulatory aged mouse oocytes by stabilizing ovastacin and Juno to promote sperm binding and fusion. / 01.03.2017 / PubMed / Full text

ZRSR2

Insight into the molecular pathophysiology of myelodysplastic syndromes: targets for novel therapy. / 10.2016 / PubMed / Full text