Материал из hpluswiki
Перейти к навигации Перейти к поиску

Parafibromin (Cell division cycle protein 73 homolog) (Hyperparathyroidism 2 protein) [C1orf28] [HRPT2]


Down-regulation of cancer-associated gene CDC73 contributes to cellular senescence.

Dysregulated gene expression is another important contributor in explaining cancer-related phenotypes in addition to mutations. Cellular senescence is a mechanism for the prevention of cancer and thus it is important to understand the regulation of gene expression in senescence due to its potential in anti-cancer therapy. Here, we found that CDC73, which encodes the cell division cycle 73 and acts as a tumor suppressor, was unexpectedly up-regulated in several cancer types but down-regulated in a variety of senescent cells. Importantly, depletion of CDC73 could induce senescence-associated phenotypes in both normal and cancer cells, with an increase in p21 expression. In terms of molecular mechanism, alternative polyadenylation (APA)-mediated 3' untranslated region (3' UTR) lengthening explained, at least in part, the decreased CDC73 expression in senescent cells because longer 3' UTR had a higher rate of RNA degradation compared to the shorter one. Our work discovered that post-transcriptional down-regulation of CDC73 contributed to cellular senescence.

MeSH Terms

  • 3' Untranslated Regions
  • Base Sequence
  • Cell Line
  • Cellular Senescence
  • Cyclin-Dependent Kinase Inhibitor p21
  • Down-Regulation
  • Gene Expression Regulation, Neoplastic
  • Gene Knockdown Techniques
  • Humans
  • Neoplasms
  • Tumor Suppressor Proteins
  • Up-Regulation


  • 3′ UTR
  • CDC73
  • Cancer
  • Cellular senescence
  • Gene expression