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HLA class II histocompatibility antigen, DQ beta 1 chain precursor (MHC class II antigen DQB1) [HLA-DQB]


Identification of new genetic variants of HLA-DQB1 associated with human longevity and lipid homeostasis-a cross-sectional study in a Chinese population.

Healthy longevity has been an unremitting pursuit of human, but its genetic and the environment causes are still unclear. As longevity population is a good healthy aging model for understanding how the body begin aging and the process of aging, and plasma lipids metabolism and balance is a very important to life maintain and physiologic functional turnover. It is important to explore how the effect of genetic variants associated long-life individuals on lipids metabolism and balance. Therefore, we developed a comparative study based population which contains 2816 longevity and 2819 control. Through whole-exome sequencing and sanger sequencing genotypes, we identified four new single nucleotide polymorphisms of HLA-DQB1(major histocompatibility complex, class II, DQ beta 1), rs41542812 rs1049107 rs1049100 rs3891176([i]P [/i]=0.048-2.811×10 for allele frequencies), associated with longevity in Chinese Longevity Cohort. Further, by analysis of the longevity-variants linked to blood lipids, we identified HLA-DQB1 rs1049107, T-carriers ([i]P [/i]=0.006, OR: 11.277; [i]P [/i]=9.095×10 , OR: 0.025; [i]P [/i]=0.047, OR: 1.901) and HLA-DQB1 rs1049100, T-carriers ([i]P [/i]=1.799×10-6, OR: 0.028) associated with lipid homeostasis in long lived individuals. Our finding showed that longevity and lipid homeostasis were associated with HLA-DQB1 and suggested that immune gene variants could act on both new function of maintaining the homeostasis and anti-aging in longevity.

MeSH Terms

  • Adult
  • Aged, 80 and over
  • Asian Continental Ancestry Group
  • Case-Control Studies
  • Chi-Square Distribution
  • China
  • Computational Biology
  • Cross-Sectional Studies
  • Databases, Genetic
  • Female
  • Gene Frequency
  • Genetic Association Studies
  • HLA-DQ beta-Chains
  • Haplotypes
  • Health Status
  • Homeostasis
  • Humans
  • Lipid Metabolism
  • Lipids
  • Longevity
  • Male
  • Middle Aged
  • Odds Ratio
  • Phenotype
  • Polymorphism, Single Nucleotide


  • Chinese population
  • HLA-DQB1
  • human longevity
  • lipid phenotypes

[Clinical and genetic characteristics of long-livers in Moscow region].

In Moscow region long-livers we have studied distribution of LPL, CETP, APOE, F2, F5, F7, F13, FGB, ITGA2, ITGB3, PAI-1, MTHFR, MTRR, HLA-DRB1, HLA-DQA1, HLA-DQB1 genes polymorphisms, associated with predisposition to age pathology. Long-livers are characterized by favorable course of cardiovascular diseases accompanied by certain genetic factors. We have established that genotype H-H- of LPL, allele epsilon2 of APOE, genotype CC of MTHFR (677C > T), genotype TC of ITGB3, genotype GA of FGB, HLA-DRB1*11 positively correlate with longevity.

MeSH Terms

  • Aged
  • Aged, 80 and over
  • Alleles
  • Cardiovascular Diseases
  • Female
  • Gene Frequency
  • Genetic Markers
  • Genetic Predisposition to Disease
  • Genotype
  • Humans
  • Longevity
  • Male
  • Moscow
  • Polymorphism, Genetic
  • Prevalence
  • Urban Population