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Fibrinogen beta chain precursor [Contains: Fibrinopeptide B; Fibrinogen beta chain]


[Clinical and genetic characteristics of long-livers in Moscow region].

In Moscow region long-livers we have studied distribution of LPL, CETP, APOE, F2, F5, F7, F13, FGB, ITGA2, ITGB3, PAI-1, MTHFR, MTRR, HLA-DRB1, HLA-DQA1, HLA-DQB1 genes polymorphisms, associated with predisposition to age pathology. Long-livers are characterized by favorable course of cardiovascular diseases accompanied by certain genetic factors. We have established that genotype H-H- of LPL, allele epsilon2 of APOE, genotype CC of MTHFR (677C > T), genotype TC of ITGB3, genotype GA of FGB, HLA-DRB1*11 positively correlate with longevity.

MeSH Terms

  • Aged
  • Aged, 80 and over
  • Alleles
  • Cardiovascular Diseases
  • Female
  • Gene Frequency
  • Genetic Markers
  • Genetic Predisposition to Disease
  • Genotype
  • Humans
  • Longevity
  • Male
  • Moscow
  • Polymorphism, Genetic
  • Prevalence
  • Urban Population