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F-box only protein 7 [FBX7]


The FBXO7 homologue nutcracker and binding partner PI31 in Drosophila melanogaster models of Parkinson's disease.

Parkinsonian-pyramidal syndrome (PPS) is an early onset form of Parkinson's disease (PD) that shows degeneration of the extrapyramidal region of the brain to result in a severe form of PD. The toxic protein build-up has been implicated in the onset of PPS. Protein removal is mediated by an intracellular proteasome complex: an E3 ubiquitin ligase, the targeting component, is essential for function. FBXO7 encodes the F-box component of the SCF E3 ubiquitin ligase linked to familial forms of PPS. The Drosophila melanogaster homologue nutcracker (ntc) and a binding partner, PI31, have been shown to be active in proteasome function. We show that altered expression of either ntc or PI31 in dopaminergic neurons leads to a decrease in longevity and locomotor ability, phenotypes both associated with models of PD. Furthermore, expression of ntc-RNAi in an established α-synuclein-dependent model of PD rescues the phenotypes of diminished longevity and locomotor control.

MeSH Terms

  • Animals
  • Animals, Genetically Modified
  • Carrier Proteins
  • Disease Models, Animal
  • Drosophila Proteins
  • Drosophila melanogaster
  • Eye
  • F-Box Proteins
  • Female
  • Gene Expression
  • Longevity
  • Male
  • Organ Specificity
  • Organogenesis
  • Parkinson Disease
  • Protein Binding
  • Protein Interaction Domains and Motifs
  • alpha-Synuclein


  • Drosophila melanogaster
  • FBXO7
  • PI31
  • Parkinson Disease
  • maladie de Parkinson
  • neurodegeneration
  • neurodégénérescence
  • nutcracker