GDF15

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Growth/differentiation factor 15 precursor (GDF-15) (Macrophage inhibitory cytokine 1) (MIC-1) (NSAID-activated gene 1 protein) (NAG-1) (NSAID-regulated gene 1 protein) (NRG-1) (Placental TGF-beta) (Placental bone morphogenetic protein) (Prostate differentiation factor) [MIC1] [PDF] [PLAB] [PTGFB]

Publications[править]

Disease-specific plasma levels of mitokines FGF21, GDF15, and Humanin in type II diabetes and Alzheimer's disease in comparison with healthy aging.


The Association of Aging Biomarkers, Interstitial Lung Abnormalities, and Mortality.


Data mining of human plasma proteins generates a multitude of highly predictive aging clocks that reflect different aspects of aging.


Mitochondria, immunosenescence and inflammaging: a role for mitokines?


Growth differentiation factor 15 protects against the aging-mediated systemic inflammatory response in humans and mice.


Analysis of Epigenetic Age Predictors in Pain-Related Conditions.


GDF15 Plasma Level Is Inversely Associated With Level of Physical Activity and Correlates With Markers of Inflammation and Muscle Weakness.


Systematic review and analysis of human proteomics aging studies unveils a novel proteomic aging clock and identifies key processes that change with age.


Systemic GDF11 stimulates the secretion of adiponectin and induces a calorie restriction-like phenotype in aged mice.


GDF15 is an epithelial-derived biomarker of idiopathic pulmonary fibrosis.


Senescence-associated tissue microenvironment promotes colon cancer formation through the secretory factor GDF15.


mTORC1 underlies age-related muscle fiber damage and loss by inducing oxidative stress and catabolism.


Expression of lipogenic markers is decreased in subcutaneous adipose tissue and adipocytes of older women and is negatively linked to GDF15 expression.


Growth differentiation factor 15 (GDF15): A survival protein with therapeutic potential in metabolic diseases.


[The role of «Youth and aging proteins» in essential hypertension pathogenesis.]


A framework for selection of blood-based biomarkers for geroscience-guided clinical trials: report from the TAME Biomarkers Workgroup.


Towards frailty biomarkers: Candidates from genes and pathways regulated in aging and age-related diseases.


Plasma proteomic signature of age in healthy humans.


Human Aging and Longevity Are Characterized by High Levels of Mitokines.


Induction of Growth Differentiation Factor 15 in Skeletal Muscle of Old Taurine Transporter Knockout Mouse.


Cigarette Smoke Induces Human Airway Epithelial Senescence via Growth Differentiation Factor 15 Production.


Secreted growth differentiation factor 15 as a potential biomarker for mitochondrial dysfunctions in aging and age-related disorders.


GDF15 contributes to radiation-induced senescence through the ROS-mediated p16 pathway in human endothelial cells.


hNAG-1 increases lifespan by regulating energy metabolism and insulin/IGF-1/mTOR signaling.