FGF23

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Fibroblast growth factor 23 precursor (FGF-23) (Phosphatonin) (Tumor-derived hypophosphatemia-inducing factor) [Contains: Fibroblast growth factor 23 N-terminal peptide; Fibroblast growth factor 23 C-terminal peptide] [HYPF] [UNQ3027/PRO9828]

Publications[править]

Phosphate as a Pathogen of Arteriosclerosis and Aging.


Plasma Soluble αKlotho, Serum Fibroblast Growth Factor 23, and Mobility Disability in Community-Dwelling Older Adults.


Astragalus improve aging bone marrow mesenchymal stem cells (BMSCs) vitality and osteogenesis through VD-FGF23-Klotho axis.


Protective effect of Polygonatum sibiricum Polysaccharide on D-galactose-induced aging rats model.


FGF23 expression is stimulated in transgenic α-Klotho longevity mouse model.


Fibroblast growth factor 23 and symmetric dimethylarginine concentrations in geriatric cats.


Muscle-bone crosstalk and potential therapies for sarco-osteoporosis.


Extraskeletal Calcifications in Hutchinson-Gilford Progeria Syndrome.


Genome-wide associations and detection of potential candidate genes for direct genetic and maternal genetic effects influencing dairy cattle body weight at different ages.


Age-Related Changes and Effects of Bisphosphonates on Bone Turnover and Disease Progression in Fibrous Dysplasia of Bone.


Kotho and aging.


The Klotho proteins in health and disease.


Wnt signaling in bone, kidney, intestine, and adipose tissue and interorgan interaction in aging.


Towards frailty biomarkers: Candidates from genes and pathways regulated in aging and age-related diseases.


New Insights into the Mechanism of Action of Soluble Klotho.


The relevance of α-KLOTHO to the central nervous system: Some key questions.

{{medline-entry |title=Fibroblast Growth Factor 23 and the Risk of Infection-Related Hospitalization in Older Adults. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/28122946 |abstract=Within monocytes, 1,25-dihydroxyvitamin D [1,25(OH) D] is important for production of cathelicidins, which in turn, are critical for antibacterial action. Fibroblast growth factor 23 (FGF23) decreases 1,25(OH) D production and thus, could increase infection risk. We examined this possibility in 3141 community-dwelling adults ages ≥65 years old at baseline in the Cardiovascular Health Study using Cox proportional hazards models to examine the association between FGF23 concentrations and first infection-related hospitalizations and determine whether associations differed by the presence of CKD (eGFR<60 ml/min per 1.73 m [[i]n[/i]=832] or urine albumin-to-creatinine ratio >30 mg/g [[i]n[/i]=577]). Mean±SD age of participants was 78±5 years old, 60% of participants were women, and the median plasma FGF23 concentration was 70 (interquartile range, 53-99) relative units per milliliter. In fully adjusted models, higher FGF23 concentrations associated with higher risk of first infection-related hospitalization (hazard ratio [HR], 1.11; 95% confidence interval [95% CI], 1.03 to 1.20 per doubling of FGF23) during a median follow-up of 8.6 years. In participants with or without CKD (defined by eGFR), FGF23 concentration associated with first infection-related hospitalization with HRs of 1.24 (95% CI, 1.08 to 1.42) and 1.06 (95% CI, 0.97 to 1.17) per doubling of FGF23, respectively ([i]P[/i]=0.13 for interaction). Associations did not differ between groups when stratified by urine albumin-to-creatinine ratio. In sensitivity analyses, the addition of serum calcium, phosphorus, 25-hydroxyvitamin D, intact parathyroid hormone, and 24,25-dihydroxyvitamin D did not meaningfully change the estimates. In conclusion, in community-dwelling older adults, higher plasma FGF23 concentrations independently associated with the risk of first infection-related hospitalization. |mesh-terms=* Aged

  • Bacterial Infections
  • Female
  • Fibroblast Growth Factors
  • Hospitalization
  • Humans
  • Longitudinal Studies
  • Male
  • Prospective Studies
  • Risk Factors

|keywords=* aging

  • chronic kidney disease
  • clinical epidemiology
  • infection
  • mineral metabolism

|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5373449 }}

Reduction of calprotectin and phosphate during testosterone therapy in aging men: a randomized controlled trial.


Association between circulating fibroblast growth factor-23 and age-related cardiovascular-renal parameters in a healthy Chinese population.


The FGF23/KLOTHO Regulatory Network and Its Roles in Human Disorders.


Wound healing delays in α-Klotho-deficient mice that have skin appearance similar to that in aged humans - Study of delayed wound healing mechanism.


Partial Reversal of Tissue Calcification and Extension of Life Span following Ammonium Nitrate Treatment of Klotho-Deficient Mice.


[Regulatory mechanism of circulating inorganic phosphate].


Biological Role of Anti-aging Protein Klotho.


Soluble αKlotho as a candidate for the biomarker of aging.


Acetazolamide sensitive tissue calcification and aging of klotho-hypomorphic mice.


N-ethyl-N-Nitrosourea (ENU) induced mutations within the klotho gene lead to ectopic calcification and reduced lifespan in mouse models.


Intracellular signaling of the aging suppressor protein Klotho.


Tumour-associated osteomalacia and hypoglycaemia in a patient with prostate cancer: is Klotho involved?


Calpain 1 inhibitor BDA-410 ameliorates α-klotho-deficiency phenotypes resembling human aging-related syndromes.


[Bone metabolism and cardiovascular function update. α-klotho/FGF23 system; a new insight into the field of mineral homeostasis and the pathogeneses of aging-associated syndromes and the complications of chronic kidney disease].


[Aging and inflammation: Klotho, diet and the kidney connection].


Significance of the anti-aging protein Klotho.


FGF23 affects the lineage fate determination of mesenchymal stem cells.


Klotho and chronic kidney disease.


Klotho and βKlotho.


Vitamin D receptor controls expression of the anti-aging klotho gene in mouse and human renal cells.


Identification of novel small molecules that elevate Klotho expression.


The role of cellular senescence during vascular calcification: a key paradigm in aging research.


Klotho interferes with a novel FGF-signalling pathway and insulin/Igf-like signalling to improve longevity and stress resistance in Caenorhabditis elegans.


Effect of sirolimus on calcineurin inhibitor-induced nephrotoxicity using renal expression of KLOTHO, an antiaging gene.


Regulation of ion channels by secreted Klotho: mechanisms and implications.


The nuclear vitamin D receptor controls the expression of genes encoding factors which feed the "Fountain of Youth" to mediate healthful aging.


A potential link between phosphate and aging--lessons from Klotho-deficient mice.


Role of FGF19 induced FGFR4 activation in the regulation of glucose homeostasis.


The influence of glomerular filtration rate and age on fibroblast growth factor 23 serum levels in pediatric chronic kidney disease.


Klotho.


[Aspects of mammalian aging from alphaklotho study].


[Fibroblast Growth Factor 23-Klotho: a new axis of phosphate balance control].


[Clinical aspect of recent progress in phosphate metabolism. FGF23; physiological action and molecular mechanism in the regulation of phosphate and vitamin D metabolism].


Vitamin D and aging.


Therapeutic effects of anti-FGF23 antibodies in hypophosphatemic rickets/osteomalacia.


Klotho and aging.


Vitamin D receptor genotype in hypophosphatemic rickets as a predictor of growth and response to treatment.


[Role of kidney in calcium homeostasis and premature aging].


Klotho as a regulator of oxidative stress and senescence.


Klotho: an antiaging protein involved in mineral and vitamin D metabolism.


[Vitamin D and phosphate metabolism; relationship with aging-regulating gene].


Toward a better understanding of Klotho.


Loss of renal phosphate wasting in a child with autosomal dominant hypophosphatemic rickets caused by a FGF23 mutation.