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Krueppel-like factor 2 (Lung krueppel-like factor) [LKLF]


KLF2 induces the senescence of pancreatic cancer cells by cooperating with FOXO4 to upregulate p21.

Pancreatic cancer is one of the most common malignancies in the world. Senescence is frequently observed in the progression of pancreatic cancer. In a previous study, we showed that KLF2 inhibited the growth and migration of pancreatic cancer. However, the mechanisms are not fully understood. In this study, we showed that overexpression of KLF2 induced the senescence of pancreatic cancer cells and inhibited tumorigenesis, and knockdown of KLF2 inhibited senescence and p21 expression. In the molecular mechanism study, KLF2 was found to interact with FOXO4 and cooperated with FOXO4 to induce the expression of p21. Downregulation of p21 and FOXO4 impaired the induction of senescence by KLF2. Overall, this study revealed the functions and mechanisms of KLF2 in senescence and provided a novel explanation for the suppressive roles of KLF2 in pancreatic cancer.

MeSH Terms

  • Animals
  • Carcinogenesis
  • Cell Cycle Proteins
  • Cell Line
  • Cells, Cultured
  • Cellular Senescence
  • Cyclin-Dependent Kinase Inhibitor p21
  • Forkhead Transcription Factors
  • Kruppel-Like Transcription Factors
  • Male
  • Mice
  • Mice, Nude
  • Pancreatic Neoplasms
  • Protein Binding
  • Up-Regulation


  • FOXO4
  • KLF2
  • Pancreatic cancer
  • Senescence