Aging genes 10-29

• Genes with 100 and more publications
• Genes with 60-99 publications
• Genes with 30-59 publications
• Genes with 10-29 publications
• Genes with 3-9 publications
• Genes with 1-2 publications

CCL2

• β1 Integrin regulates adult lung alveolar epithelial cell inflammation. / 30.01.2020 / PubMed / Full text
• Neuroprotective effects of targeting BET proteins for degradation with dBET1 in aged mice subjected to ischemic stroke. / 07.2019 / PubMed / Full text
• Membrane metallo-endopeptidase mediates cellular senescence induced by oncogenic PIK3CA accompanied with pro-tumorigenic secretome. / 01.08.2019 / PubMed / Full text
• Isoflurane anesthesia impairs the expression of immune neuromodulators in the hippocampus of aged mice. / 2018 / PubMed / Full text
• Melatonin and inflammation-Story of a double-edged blade. / 11.2018 / PubMed / Full text
• Defective autophagy in vascular smooth muscle cells enhances cell death and atherosclerosis. / 2018 / PubMed / Full text
• Urine Cytokine and Chemokine Levels Predict Urinary Tract Infection Severity Independent of Uropathogen, Urine Bacterial Burden, Host Genetics, and Host Age. / 09.2018 / PubMed / Full text
• Infiltrating macrophages contribute to age-related neuroinflammation in C57/BL6 mice. / 07.2018 / PubMed / Full text
• Time-Dependent Changes in Local and Serum Levels of Inflammatory Cytokines as Markers for Incised Wound Aging of Skeletal Muscles. / 05.2018 / PubMed / Full text
• Age-related pro-inflammatory and pro-angiogenic changes in human aqueous humor. / 2018 / PubMed / Full text
• Immune senescence and biomarkers profile of Bambuí aged population-based cohort. / 03.2018 / PubMed / Full text
• Selected life-extending interventions reduce arterial CXCL10 and macrophage colony-stimulating factor in aged mouse arteries. / 08.2017 / PubMed / Full text
• Strain specificities in cellular and molecular immunopathogenic mechanisms underlying development of experimental autoimmune encephalomyelitis in aged rats. / 06.2017 / PubMed / Full text
• Advanced atherosclerosis is associated with inflammation, vascular dysfunction and oxidative stress, but not hypertension. / 02.2017 / PubMed / Full text
• An attenuated immune response by Schwann cells and macrophages inhibits nerve regeneration in aged rats. / 09.2016 / PubMed / Full text
• Enhanced Ccl2-Ccr2 signaling drives more severe choroidal neovascularization with aging. / 04.2016 / PubMed / Full text
• Agmatine Ameliorates High Glucose-Induced Neuronal Cell Senescence by Regulating the p21 and p53 Signaling. / 02.2016 / PubMed / Full text
• Alterations in Monocyte Phenotypes and Functions after a Hip Fracture in Elderly Individuals: A 6-Month Longitudinal Study. / 2016 / PubMed / Full text
• Elevated Levels of Microbial Translocation Markers and CCL2 Among Older HIV-1-Infected Men. / 01.03.2016 / PubMed / Full text
• APOE Isoforms Control Pathogenic Subretinal Inflammation in Age-Related Macular Degeneration. / 07.10.2015 / PubMed / Full text
• Colorectal cancer-promoting activity of the senescent peritoneal mesothelium. / 06.10.2015 / PubMed / Full text
• Nilotinib and bosutinib modulate pre-plaque alterations of blood immune markers and neuro-inflammation in Alzheimer's disease models. / 24.09.2015 / PubMed / Full text
• Neuroimmune and Neuropathic Responses of Spinal Cord and Dorsal Root Ganglia in Middle Age. / 2015 / PubMed / Full text
• Microglial Kv1.3 Channels and P2Y12 Receptors Differentially Regulate Cytokine and Chemokine Release from Brain Slices of Young Adult and Aged Mice. / 2015 / PubMed / Full text
• CCL2, CXCL8, CXCL9 and CXCL10 serum levels increase with age but are not altered by treatment with hydroxychloroquine in patients with osteoarthritis of the knees. / 12.2017 / PubMed / Full text
• Senescent dermal fibroblasts enhance stem cell migration through CCL2/CCR2 axis. / 07.2015 / PubMed / Full text
• Age-associated changes in basal NF-κB function in human CD4 T lymphocytes via dysregulation of PI3 kinase. / 11.2014 / PubMed / Full text
• IL-4 signaling drives a unique arginase /IL-1β microglia phenotype and recruits macrophages to the inflammatory CNS: consequences of age-related deficits in IL-4Rα after traumatic spinal cord injury. / 25.06.2014 / PubMed / Full text
• Systemic inflammation impairs attention and cognitive flexibility but not associative learning in aged rats: possible implications for delirium. / 2014 / PubMed / Full text

EGFR

• Type I Collagen Aging Increases Expression and Activation of EGFR and Induces Resistance to Erlotinib in Lung Carcinoma in 3D Matrix Model. / 2020 / PubMed / Full text
• Comparative effectiveness and cost-effectiveness of three first-line EGFR-tyrosine kinase inhibitors: Analysis of real-world data in a tertiary hospital in Taiwan. / 2020 / PubMed / Full text
• An Optogenetic Method to Study Signal Transduction in Intestinal Stem Cell Homeostasis. / 01.05.2020 / PubMed / Full text
• Treatment-Induced Tumor Dormancy through YAP-Mediated Transcriptional Reprogramming of the Apoptotic Pathway. / 13.01.2020 / PubMed / Full text
• Association between EGFR mutation and ageing, history of pneumonia and gastroesophageal reflux disease among patients with advanced lung cancer. / 11.2019 / PubMed / Full text
• Systems biology and network pharmacology of frailty reveal novel epigenetic targets and mechanisms. / 22.07.2019 / PubMed / Full text
• The role of EGFR signaling in age-related osteoporosis in mouse cortical bone. / 10.2019 / PubMed / Full text
• Regulation of RhoB Gene Expression during Tumorigenesis and Aging Process and Its Potential Applications in These Processes. / 13.06.2019 / PubMed / Full text
• EGF/EGFR upregulates and cooperates with Netrin-4 to protect glioblastoma cells from DNA damage-induced senescence. / 04.12.2018 / PubMed / Full text
• An Adult Drosophila Glioma Model for Studying Pathometabolic Pathways of Gliomagenesis. / 06.2019 / PubMed / Full text
• Quantum Modeling: A Bridge between the Pumping and Signaling Functions of Na/K-ATPase. / 09.08.2018 / PubMed / Full text
• Novel drug-resistance mechanisms of pemetrexed-treated non-small cell lung cancer. / 30.03.2018 / PubMed / Full text
• Withanolide A extends the lifespan in human EGFR-driven cancerous Caenorhabditis elegans. / 04.2018 / PubMed / Full text
• 30 YEARS OF THE MINERALOCORTICOID RECEPTOR: Nongenomic effects via the mineralocorticoid receptor. / 07.2017 / PubMed / Full text
• Inverse relationship between Alzheimer's disease and cancer, and other factors contributing to Alzheimer's disease: a systematic review. / 22.11.2016 / PubMed / Full text
• Low-frequency [i]KRAS[/i] mutations are prevalent in lung adenocarcinomas. / 03.2015 / PubMed / Full text
• Association of Polymorphisms in Connective Tissue Growth Factor and Epidermal Growth Factor Receptor Genes With Human Longevity. / 01.08.2017 / PubMed / Full text
• sPLA2 -IIA Overexpression in Mice Epidermis Depletes Hair Follicle Stem Cells and Induces Differentiation Mediated Through Enhanced JNK/c-Jun Activation. / 09.2016 / PubMed / Full text
• Mechanisms of skin aging induced by EGFR inhibitors. / 10.2016 / PubMed / Full text
• Prolactin, EGFR, vimentin and α-actin profiles in elderly rat prostate subjected to steroid hormonal imbalance. / 06.2016 / PubMed / Full text
• Loss of Maspardin Attenuates the Growth and Maturation of Mouse Cortical Neurons. / 2016 / PubMed / Full text
• Expression profile analysis of new candidate genes for the therapy of primary osteoporosis. / 2016 / PubMed
• Selective coexpression of VEGF receptor 2 in EGFRvIII-positive glioblastoma cells prevents cellular senescence and contributes to their aggressive nature. / 05.2016 / PubMed / Full text
• Bradykinin inhibits oxidative stress-induced senescence of endothelial progenitor cells through the B2R/AKT/RB and B2R/EGFR/RB signal pathways. / 22.09.2015 / PubMed / Full text
• First-line gefitinib treatment in elderly patients (aged ≥75 years) with non-small cell lung cancer harboring EGFR mutations. / 10.2015 / PubMed / Full text
• Increased centrosome amplification in aged stem cells of the Drosophila midgut. / 25.07.2014 / PubMed / Full text
• Prospective identification of functionally distinct stem cells and neurosphere-initiating cells in adult mouse forebrain. / 07.05.2014 / PubMed / Full text
• Thiamin concentration in geriatric hospitalized patients using frusemide. / 2014 / PubMed / Full text
• 4-Hydroxynonenal impairs transforming growth factor-β1-induced elastin synthesis via epidermal growth factor receptor activation in human and murine fibroblasts. / 06.2014 / PubMed / Full text

LBP

• Lipopolysaccharide binding protein is associated with CVD risk in older adults. / 08.09.2020 / PubMed / Full text
• Aging-related liver degeneration is associated with increased bacterial endotoxin and lipopolysaccharide binding protein levels. / 01.04.2020 / PubMed / Full text
• Biomarkers of leaky gut are related to inflammation and reduced physical function in older adults with cardiometabolic disease and mobility limitations. / 12.2019 / PubMed / Full text
• Needle-shaped amyloid deposition in rat mammary gland: evidence of a novel amyloid fibril protein. / 03.2020 / PubMed / Full text
• Effects of Lycium barbarum Polysaccharides on Health and Aging of [i]C. elegans[/i] Depend on [i]daf-12/daf-16[/i]. / 2019 / PubMed / Full text
• Structural characterization of life-extending Caenorhabditis elegans Lipid Binding Protein 8. / 10.07.2019 / PubMed / Full text
• Lycium barbarum polysaccharides extend the mean lifespan of Drosophila melanogaster. / 17.07.2019 / PubMed / Full text
• Height loss but not body composition is related to low back pain in community-dwelling elderlies: Shimane CoHRE study. / 10.05.2019 / PubMed / Full text
• Aging of mouse intervertebral disc and association with back pain. / 06.2019 / PubMed / Full text
• A comparison of the mitochondrial proteome and lipidome in the mouse and long-lived Pipistrelle bats. / 19.03.2019 / PubMed / Full text
• Chen-Style Tai Chi for Individuals (Aged 50 Years Old or Above) with Chronic Non-Specific Low Back Pain: A Randomized Controlled Trial. / 12.02.2019 / PubMed / Full text
• Lysosomal Signaling Promotes Longevity by Adjusting Mitochondrial Activity. / 11.03.2019 / PubMed / Full text
• Factors associated with lumbar disc high-intensity zone (HIZ) on T2-weighted magnetic resonance image: a retrospective study of 3185 discs in 637 patients. / 04.12.2018 / PubMed / Full text
• Urolithin A Inhibits the Catabolic Effect of TNFα on Nucleus Pulposus Cell and Alleviates Intervertebral Disc Degeneration [i]in vivo[/i]. / 2018 / PubMed / Full text
• Use of trunk muscle training and neuromuscular electrical stimulation to reduce pain and disability in an older adult with chronic low back pain: A case report. / 08.2019 / PubMed / Full text
• Endotoxemia is modulated by quantity and quality of dietary fat in older adults. / 08.2018 / PubMed / Full text
• Correlates of a Recent History of Disabling Low Back Pain in Community-dwelling Older Persons: The Pain in the Elderly (PAINEL) Study. / 06.2018 / PubMed / Full text
• The Effectiveness and Safety of Manual Therapy on Pain and Disability in Older Persons With Chronic Low Back Pain: A Systematic Review. / 09.2017 / PubMed / Full text
• De-educate to re-educate: aging and low back pain. / 12.2017 / PubMed / Full text
• Activity of Erector Spinae During Trunk Forward Bending and Backward Return: The Effects of Age. / 06.2017 / PubMed / Full text
• Global Cysteine-Reactivity Profiling during Impaired Insulin/IGF-1 Signaling in C. elegans Identifies Uncharacterized Mediators of Longevity. / 18.08.2016 / PubMed / Full text
• Age- and brain region-dependent α-synuclein oligomerization is attributed to alterations in intrinsic enzymes regulating α-synuclein phosphorylation in aging monkey brains. / 23.02.2016 / PubMed / Full text
• Association of Lipopolysaccharide-Binding Protein With Aging-Related Adiposity Change and Prediabetes Among African Ancestry Men. / 03.2016 / PubMed / Full text
• Age-related differences in trunk intrinsic stiffness. / 11.04.2016 / PubMed / Full text
• Probiotics Reduce Inflammation in Antiretroviral Treated, HIV-Infected Individuals: Results of the "Probio-HIV" Clinical Trial. / 2015 / PubMed / Full text
• The effects of age and gender on the lumbopelvic rhythm in the sagittal plane in 309 subjects. / 18.09.2015 / PubMed / Full text
• Does physical activity moderate the relationship between depression symptomatology and low back pain? Cohort and co-twin control analyses nested in the longitudinal study of aging Danish twins (LSADT). / 04.2016 / PubMed / Full text
• Aging. Lysosomal signaling molecules regulate longevity in Caenorhabditis elegans. / 02.01.2015 / PubMed / Full text
• Comparative study of human age estimation with or without preclassification of gender and facial expression. / 2014 / PubMed / Full text

LPA

• Ginseng gintonin, aging societies, and geriatric brain diseases. / 03.2021 / PubMed / Full text
• Late-life related subtypes of depression - a data-driven approach on cognitive domains and physical frailty. / 22.05.2020 / PubMed / Full text
• Does sedentary time increase in older adults in the days following participation in intense exercise? / 12.2020 / PubMed / Full text
• Association of Long-term Exposure to Elevated Lipoprotein(a) Levels With Parental Life Span, Chronic Disease-Free Survival, and Mortality Risk: A Mendelian Randomization Analysis. / 05.02.2020 / PubMed / Full text
• Elevated Autotaxin and LPA Levels During Chronic Viral Hepatitis and Hepatocellular Carcinoma Associate with Systemic Immune Activation. / 25.11.2019 / PubMed / Full text
• Lysophosphatidic acid receptor LPA prevents oxidative stress and cellular senescence in Hutchinson-Gilford progeria syndrome. / 01.2020 / PubMed / Full text
• Associations of Sedentary and Physically-Active Behaviors With Cognitive-Function Decline in Community-Dwelling Older Adults: Compositional Data Analysis From the NEIGE Study. / 05.11.2020 / PubMed / Full text
• Validation and comparison of two automated methods for quantifying brain white matter hyperintensities of presumed vascular origin. / 02.2020 / PubMed / Full text
• The Sedentary Time and Physical Activity Levels on Physical Fitness in the Elderly: A Comparative Cross Sectional Study. / 01.10.2019 / PubMed / Full text
• Light-Intensity Physical Activity in a Large Prospective Cohort of Older US Adults: A 21-Year Follow-Up of Mortality. / 2020 / PubMed / Full text
• The Impact of Movement Behaviors on Bone Health in Elderly with Adequate Nutritional Status: Compositional Data Analysis Depending on the Frailty Status. / 09.03.2019 / PubMed / Full text
• Compositional Influence of Movement Behaviors on Bone Health during Aging. / 08.2019 / PubMed / Full text
• Duration-Response of Light-Intensity Physical Activity and Glucose Dynamics in Older Adults. / 01.01.2019 / PubMed / Full text
• Accelerometer-Measured Physical Activity and Sedentary Behavior: A Cross-Sectional Study of Brazilian Older Adults. / 01.11.2018 / PubMed / Full text
• The Association Between Physical Activity, Including Physical Activity Intensity, and Fear of Falling Differs by Fear Severity in Older Adults Living in the Community. / 16.04.2020 / PubMed / Full text
• Gintonin Attenuates D-Galactose-Induced Hippocampal Senescence by Improving Long-Term Hippocampal Potentiation, Neurogenesis, and Cognitive Functions. / 2018 / PubMed / Full text
• Associations of distinct levels of physical activity with mobility in independent healthy older women. / 09.2018 / PubMed / Full text
• Reallocating Accelerometer-Assessed Sedentary Time to Light or Moderate- to Vigorous-Intensity Physical Activity Reduces Frailty Levels in Older Adults: An Isotemporal Substitution Approach in the TSHA Study. / 02.2018 / PubMed / Full text
• Lean psoas area does not correlate with clinical outcomes in moderately to severely injured older people. / 03.2018 / PubMed / Full text
• Genome-wide meta-analysis associates HLA-DQA1/DRB1 and LPA and lifestyle factors with human longevity. / 13.10.2017 / PubMed / Full text
• Stress, Depression, Resilience and Ageing: A Role for the LPA-LPA1 Pathway. / 05.03.2018 / PubMed / Full text
• A New Anti-Aging Lysophosphatidic Acid from Arabidopsis thaliana. / 2017 / PubMed / Full text
• Short-duration increases in intraluminal pressure improve vasoconstrictor responses in aged skeletal muscle feed arteries. / 05.2016 / PubMed / Full text
• Hearing loss and cognition in the Busselton Baby Boomer cohort: An epidemiological study. / 10.2016 / PubMed / Full text
• The Bulk of Autotaxin Activity Is Dispensable for Adult Mouse Life. / 2015 / PubMed / Full text
• Cognitive function in midlife and beyond: physical and cognitive activity related to episodic memory and executive functions. / 2014 / PubMed / Full text
• Effect of light and vigorous physical activity on balance and gait of older adults. / 11-12.2014 / PubMed / Full text
• Inverse effects of midlife occupational and leisure time physical activity on mobility limitation in old age--a 28-year prospective follow-up study. / 05.2014 / PubMed / Full text

NPY

• Neuropeptide Y Enhances Progerin Clearance and Ameliorates the Senescent Phenotype of Human Hutchinson-Gilford Progeria Syndrome Cells. / 22.05.2020 / PubMed / Full text
• Effects of rikkunshito supplementation on resistance to oxidative stress and lifespan in mice. / 03.2020 / PubMed / Full text
• Autophagy within the mushroom body protects from synapse aging in a non-cell autonomous manner. / 21.03.2019 / PubMed / Full text
• β-Alanine supplementation reduces anxiety and increases neurotrophin expression in both young and older rats. / 02.2019 / PubMed / Full text
• Age-related central regulation of orexin and NPY in the short-lived African killifish Nothobranchius furzeri. / 15.05.2019 / PubMed / Full text
• Chronic treatment with tributyltin induces sexually dimorphic alterations in the hypothalamic POMC system of adult mice. / 12.2018 / PubMed / Full text
• Expression of CGRP neurotransmitter and vascular genesis marker mRNA is age-dependent in superior cervical ganglia of senescence-accelerated prone mice. / 18.01.2018 / PubMed / Full text
• Comparing the Effects of Melatonin with Caloric Restriction in the Hippocampus of Aging Mice: Involvement of Sirtuin1 and the FOXOs Pathway. / 01.2018 / PubMed / Full text
• Bioactive growth hormone in older men and women: It's relationship to immune markers and healthspan. / 06.2017 / PubMed / Full text
• Retinal, NPY- and 5ht- inputs to the aged suprachiasmatic nucleus in common marmosets (Callithrix jacchus). / 08.2017 / PubMed / Full text
• Long-lasting memory deficits in mice withdrawn from cocaine are concomitant with neuroadaptations in hippocampal basal activity, GABAergic interneurons and adult neurogenesis. / 01.03.2017 / PubMed / Full text
• Neuropeptide Y resists excess loss of fat by lipolysis in calorie-restricted mice: a trait potential for the life-extending effect of calorie restriction. / 04.2017 / PubMed / Full text
• Nerve growth factor-induced plasticity in medial prefrontal cortex interneurons of aged Wistar rats. / 01.12.2016 / PubMed / Full text
• Age Impaired endothelium-dependent vasodilation is improved by resveratrol in rat mesenteric arteries. / 31.03.2016 / PubMed / Full text
• Age-related changes in neurochemical components and retinal projections of rat intergeniculate leaflet. / 02.2016 / PubMed / Full text
• Short photoperiod condition increases susceptibility to stress in adolescent male rats. / 01.03.2016 / PubMed / Full text
• Neuropeptide Y: An Anti-Aging Player? / 11.2015 / PubMed / Full text
• Influence of Aging and Gender Differences on Feeding Behavior and Ghrelin-Related Factors during Social Isolation in Mice. / 2015 / PubMed / Full text
• Reduction in NPY-positive neurons and dysregulation of excitability in young senescence-accelerated mouse prone 8 (SAMP8) hippocampus precede the onset of cognitive impairment. / 10.2015 / PubMed / Full text
• Age effects on the nucleus of the lateral olfactory tract of the rat. / 01.03.2016 / PubMed / Full text
• NPY/neuropeptide Y enhances autophagy in the hypothalamus: a mechanism to delay aging? / 2015 / PubMed / Full text
• Analysis of gene expression during aging of CGNs in culture: implication of SLIT2 and NPY in senescence. / 06.2015 / PubMed / Full text
• Neuropeptide Y stimulates autophagy in hypothalamic neurons. / 31.03.2015 / PubMed / Full text
• Effect of IP3R3 and NPY on age-related declines in olfactory stem cell proliferation. / 02.2015 / PubMed / Full text
• Old-onset caloric restriction effects on neuropeptide Y- and somatostatin-containing neurons and on cholinergic varicosities in the rat hippocampal formation. / 2014 / PubMed / Full text
• Orally administered δ opioid agonist peptide rubiscolin-6 stimulates food intake in aged mice with ghrelin resistance. / 10.2014 / PubMed / Full text
• Ghrelin receptor regulates appetite and satiety during aging in mice by regulating meal frequency and portion size but not total food intake. / 09.2014 / PubMed / Full text
• Distribution of peptidergic populations in the human dentate gyrus (somatostatin [SOM-28, SOM-12] and neuropeptide Y [[[NPY]]]) during postnatal development. / 10.2014 / PubMed / Full text

ATF4

• Endoplasmic Reticulum Stress Mediates Vascular Smooth Muscle Cell Calcification via Increased Release of Grp78-Loaded Extracellular Vesicles. / 10.12.2020 / PubMed / Full text
• Extracellular acidosis triggers a senescence-like phenotype in human melanoma cells. / 01.2020 / PubMed / Full text
• Chronic and age-dependent effects of the spongiform neurodegeneration-associated MGRN1 E3 ubiquitin ligase on mitochondrial homeostasis. / 06.2019 / PubMed / Full text
• Expression of lipogenic markers is decreased in subcutaneous adipose tissue and adipocytes of older women and is negatively linked to GDF15 expression. / 08.2019 / PubMed / Full text
• Effects of a resistance-training programme on endoplasmic reticulum unfolded protein response and mitochondrial functions in PBMCs from elderly subjects. / 08.2019 / PubMed / Full text
• [Protective effect of Wuzi Yanzong recipe on testicular germ cell apoptosis in natural ageing rats through endoplasmic reticulum stress]. / 10.2018 / PubMed / Full text
• Protective effect of Wuzi Yanzong recipe on testicular dysfunction through inhibition of germ cell apoptosis in ageing rats via endoplasmic reticulum stress. / 03.2019 / PubMed / Full text
• Loss of NRF-2 and PGC-1α genes leads to retinal pigment epithelium damage resembling dry age-related macular degeneration. / 01.2019 / PubMed / Full text
• Inhibition of glioma growth by flavokawain B is mediated through endoplasmic reticulum stress induced autophagy. / 2018 / PubMed / Full text
• De-silencing [i]Grb10[/i] contributes to acute ER stress-induced steatosis in mouse liver. / 05.2018 / PubMed / Full text
• Resveratrol modulates response against acute inflammatory stimuli in aged mouse brain. / 02.2018 / PubMed / Full text
• Integrated stress response stimulates FGF21 expression: Systemic enhancer of longevity. / 12.2017 / PubMed / Full text
• Role of ATF4 in skeletal muscle atrophy. / 05.2017 / PubMed / Full text
• 4E-BP is a target of the GCN2-ATF4 pathway during Drosophila development and aging. / 02.01.2017 / PubMed / Full text
• Diaminodiphenyl sulfone-induced parkin ameliorates age-dependent dopaminergic neuronal loss. / 05.2016 / PubMed / Full text
• Different Roles of Negative and Positive Components of the Circadian Clock in Oncogene-induced Neoplastic Transformation. / 13.05.2016 / PubMed / Full text
• Differentiated embryo chondrocyte 1 (DEC1) is a novel negative regulator of hepatic fibroblast growth factor 21 (FGF21) in aging mice. / 15.01.2016 / PubMed / Full text
• Unfolded protein response is activated in aged retinas. / 16.11.2015 / PubMed / Full text
• Identification and Small Molecule Inhibition of an Activating Transcription Factor 4 (ATF4)-dependent Pathway to Age-related Skeletal Muscle Weakness and Atrophy. / 16.10.2015 / PubMed / Full text
• Effect of mitochondrial stress on systemic metabolism. / 09.2015 / PubMed / Full text
• Senescence may mediate conversion of tau phosphorylation-induced apoptotic escape to neurodegeneration. / 08.2015 / PubMed / Full text
• Impact of ER stress-regulated ATF4/p16 signaling on the premature senescence of renal tubular epithelial cells in diabetic nephropathy. / 15.04.2015 / PubMed / Full text
• ATF4 activity: a common feature shared by many kinds of slow-aging mice. / 12.2014 / PubMed / Full text
• The unfolded protein response is triggered following a single, unaccustomed resistance-exercise bout. / 15.09.2014 / PubMed / Full text
• Methionine restriction restores a younger metabolic phenotype in adult mice with alterations in fibroblast growth factor 21. / 10.2014 / PubMed / Full text
• The first international mini-symposium on methionine restriction and lifespan. / 2014 / PubMed / Full text
• Elevated ATF4 function in fibroblasts and liver of slow-aging mutant mice. / 03.2015 / PubMed / Full text

DDT

• Prognostic Value of a Test of Central Auditory Function in Conversion from Mild Cognitive Impairment to Dementia. / 2020 / PubMed / Full text
• Uptake kinetics of four hydrophobic organic pollutants in the earthworm Eisenia andrei in aged laboratory-contaminated natural soils. / 01.04.2020 / PubMed / Full text
• Adult exposure to insecticides causes persistent behavioral and neurochemical alterations in zebrafish. / 03-04.2020 / PubMed / Full text
• Second generation effects of larval metal pollutant exposure on reproduction, longevity and insecticide tolerance in the major malaria vector Anopheles arabiensis (Diptera: Culicidae). / 07.01.2020 / PubMed / Full text
• Protective effect of Pedro-Ximénez must against p,p'-DDE-induced liver damages in aged Mus spretus mice. / 02.2020 / PubMed / Full text
• Low-dose endosulfan inhibits proliferation and induces senescence and pro-inflammatory cytokine production in human lymphocytes, preferentially impacting cytotoxic cells. / 12.2019 / PubMed / Full text
• DNA damage tolerance in stem cells, ageing, mutagenesis, disease and cancer therapy. / 22.08.2019 / PubMed / Full text
• The contribution of gut bacteria to insecticide resistance and the life histories of the major malaria vector Anopheles arabiensis (Diptera: Culicidae). / 24.06.2019 / PubMed / Full text
• Exposure to the insecticide-treated bednet PermaNet 2.0 reduces the longevity of the wild African malaria vector Anopheles funestus but GSTe2-resistant mosquitoes live longer. / 2019 / PubMed / Full text
• The occurrence and dynamics of polychlorinated hydrocarbons in roe deer ([i]Capreolus capreolus[/i]) in South-western Slovakia. / 2019 / PubMed / Full text
• Insecticide resistance status of three vectors of Japanese encephalitis in east central India. / 06.2019 / PubMed / Full text
• Effect of aging on bioaccessibility of DDTs and PCBs in marine sediment. / 02.2019 / PubMed / Full text
• The effect of commercial herbicide exposure on the life history and insecticide resistance phenotypes of the major malaria vector Anopheles arabiensis (Diptera: culicidae). / 12.2018 / PubMed / Full text
• Is Chronic Exposure to Low-Dose Organochlorine Pesticides a New Risk Factor of T-cell Immunosenescence? / 10.2018 / PubMed / Full text
• The influence of age on insecticide susceptibility of Anopheles arabiensis during dry and rainy seasons in rice irrigation schemes of Northern Tanzania. / 11.09.2017 / PubMed / Full text
• DNA damage tolerance in hematopoietic stem and progenitor cells in mice. / 15.08.2017 / PubMed / Full text
• The effects of ingestion of hormonal host factors on the longevity and insecticide resistance phenotype of the major malaria vector Anopheles arabiensis (Diptera: Culicidae). / 2017 / PubMed / Full text
• Bioavailability of five hydrophobic organic compounds to earthworms from sterile and non-sterile artificial soils. / 07.2017 / PubMed / Full text
• The effect of elevated temperatures on the life history and insecticide resistance phenotype of the major malaria vector Anopheles arabiensis (Diptera: Culicidae). / 14.02.2017 / PubMed / Full text
• Dichotic Digits Test Performance Across the Ages: Results From Two Large Epidemiologic Cohort Studies. / 05-06.2017 / PubMed / Full text
• The Role of Oxidative Stress in the Longevity and Insecticide Resistance Phenotype of the Major Malaria Vectors Anopheles arabiensis and Anopheles funestus. / 2016 / PubMed / Full text
• Nuclear hormone receptor DHR96 mediates the resistance to xenobiotics but not the increased lifespan of insulin-mutant Drosophila. / 02.02.2016 / PubMed / Full text
• Influence of feeding and earthworm density on compound bioaccumulation in earthworms Eisenia andrei. / 12.2015 / PubMed / Full text
• Greater cognitive decline with aging among elders with high serum concentrations of organochlorine pesticides. / 2015 / PubMed / Full text
• The effect of multiple blood-feeding on the longevity and insecticide resistant phenotype in the major malaria vector Anopheles arabiensis (Diptera: Culicidae). / 23.08.2014 / PubMed / Full text
• The role of canine distemper virus and persistent organic pollutants in mortality patterns of Caspian seals (Pusa caspica). / 2014 / PubMed / Full text
• Solid phase microextraction of organic pollutants from natural and artificial soils and comparison with bioaccumulation in earthworms. / 02.2014 / PubMed / Full text

FOXO1

• l-Theanine attenuates liver aging by inhibiting advanced glycation end products in d-galactose-induced rats and reversing an imbalance of oxidative stress and inflammation. / 03.2020 / PubMed / Full text
• Establishment of a Mouse Model of Premature Ovarian Failure Using Consecutive Superovulation. / 2018 / PubMed / Full text
• Functional pathways regulated by microRNA networks in CD8 T-cell aging. / 02.2019 / PubMed / Full text
• Introduction to FOXO Biology. / 2019 / PubMed / Full text
• Antioxidant modifications induced by the new metformin derivative HL156A regulate metabolic reprogramming in SAMP1/kl (-/-) mice. / 16.09.2018 / PubMed / Full text
• Master athletes have higher miR-7, SIRT3 and SOD2 expression in skeletal muscle than age-matched sedentary controls. / 10.2018 / PubMed / Full text
• FOXO1 and ETV6 genes may represent novel regulators of splicing factor expression in cellular senescence. / 01.2019 / PubMed / Full text
• Autophagy mediators (FOXO1, SESN3 and TSC2) in Lewy body disease and aging. / 25.09.2018 / PubMed / Full text
• FOXO are required for intervertebral disk homeostasis during aging and their deficiency promotes disk degeneration. / 10.2018 / PubMed / Full text
• Senescence Alters PPARγ (Peroxisome Proliferator-Activated Receptor Gamma)-Dependent Fatty Acid Handling in Human Adipose Tissue Microvascular Endothelial Cells and Favors Inflammation. / 05.2018 / PubMed / Full text
• HGF and BFGF Secretion by Human Adipose-Derived Stem Cells Improves Ovarian Function During Natural Aging via Activation of the SIRT1/FOXO1 Signaling Pathway. / 2018 / PubMed / Full text
• Role of Forkhead Box O (FOXO) transcription factor in aging and diseases. / 30.03.2018 / PubMed / Full text
• FOXO in Neural Cells and Diseases of the Nervous System. / 2018 / PubMed / Full text
• Clearance of senescent decidual cells by uterine natural killer cells in cycling human endometrium. / 11.12.2017 / PubMed / Full text
• FOXO Transcriptional Factors and Long-Term Living. / 2017 / PubMed / Full text
• Aquatide Activation of SIRT1 Reduces Cellular Senescence through a SIRT1-FOXO1-Autophagy Axis. / 01.09.2017 / PubMed / Full text
• The protein kinase MBK-1 contributes to lifespan extension in [i]daf-2[/i] mutant and germline-deficient [i]Caenorhabditis elegans[/i]. / 25.05.2017 / PubMed / Full text
• Melatonin regulates the aging mouse hippocampal homeostasis via the sirtuin1-FOXO1 pathway. / 2017 / PubMed / Full text
• Caloric restriction delays early phases of carcinogenesis via effects on the tissue microenvironment. / 30.05.2017 / PubMed / Full text
• Age-related reduction in the expression of FOXO transcription factors and correlations with intervertebral disc degeneration. / 12.2017 / PubMed / Full text
• Oxidative Stress-Induced miR-200c Disrupts the Regulatory Loop Among SIRT1, FOXO1, and eNOS. / 20.08.2017 / PubMed / Full text
• miR-96, miR-145 and miR-9 expression increases, and IGF-1R and FOXO1 expression decreases in peripheral blood mononuclear cells of aging humans. / 30.11.2016 / PubMed / Full text
• Cone Viability Is Affected by Disruption of Melatonin Receptors Signaling. / 01.01.2016 / PubMed / Full text
• Effect of Aging on Periodontal Inflammation, Microbial Colonization, and Disease Susceptibility. / 04.2016 / PubMed / Full text
• Long live FOXO: unraveling the role of FOXO proteins in aging and longevity. / 04.2016 / PubMed / Full text
• Abrogation of Age-Induced MicroRNA-195 Rejuvenates the Senescent Mesenchymal Stem Cells by Reactivating Telomerase. / 01.2016 / PubMed / Full text
• Endogenous ROS levels are increased in replicative senescence in human bone marrow mesenchymal stromal cells. / 15.05.2015 / PubMed / Full text

HMGB1

• Senescent human melanocytes drive skin ageing via paracrine telomere dysfunction. / 02.12.2019 / PubMed / Full text
• Targeting HMGB1 by ethyl pyruvate ameliorates systemic lupus erythematosus and reverses the senescent phenotype of bone marrow-mesenchymal stem cells. / 14.07.2019 / PubMed / Full text
• HMGB1 and Caveolin-1 related to RPE cell senescence in age-related macular degeneration. / 07.07.2019 / PubMed / Full text
• Dual faced HMGB1 plays multiple roles in cardiomyocyte senescence and cardiac inflammatory injury. / 06.2019 / PubMed / Full text
• Neuroprotective Effect of Dioscin on the Aging Brain. / 30.03.2019 / PubMed / Full text
• Modulation of soluble receptor for advanced glycation end-products (RAGE) isoforms and their ligands in healthy aging. / 23.03.2019 / PubMed / Full text
• Cellular senescence in progenitor cells contributes to diminished remyelination potential in progressive multiple sclerosis. / 30.04.2019 / PubMed / Full text
• Serum and nutrient deprivation increase autophagic flux in intervertebral disc annulus fibrosus cells: an in vitro experimental study. / 05.2019 / PubMed / Full text
• Sirt3 mediates the protective effect of hydrogen in inhibiting ROS-induced retinal senescence. / 01.05.2019 / PubMed / Full text
• Towards frailty biomarkers: Candidates from genes and pathways regulated in aging and age-related diseases. / 11.2018 / PubMed / Full text
• Repeated abortion in adulthood induces cognition impairment in aged mice. / 30.07.2018 / PubMed / Full text
• Loss of DNA polymerase β induces cellular senescence. / 08.2018 / PubMed / Full text
• Nicotine-Induced Neuroprotection against Cognitive Dysfunction after Partial Hepatectomy Involves Activation of BDNF/TrkB Signaling Pathway and Inhibition of NF-κB Signaling Pathway in Aged Rats. / 06.03.2018 / PubMed / Full text
• Intestinal Permeability Biomarker Zonulin is Elevated in Healthy Aging. / 01.09.2017 / PubMed / Full text
• Disruption of the Cx43/miR21 pathway leads to osteocyte apoptosis and increased osteoclastogenesis with aging. / 06.2017 / PubMed / Full text
• Changes in pro-inflammatory markers and leucine concentrations in response to Nordic Walking training combined with vitamin D supplementation in elderly women. / 08.2017 / PubMed / Full text
• Systemic HMGB1 Neutralization Prevents Postoperative Neurocognitive Dysfunction in Aged Rats. / 2016 / PubMed / Full text
• The Alarmin HMGB1 Mediates Age-Induced Neuroinflammatory Priming. / 27.07.2016 / PubMed / Full text
• Human fetal membranes at term: Dead tissue or signalers of parturition? / 08.2016 / PubMed / Full text
• Modulation of Macrophage Polarization and HMGB1-TLR2/TLR4 Cascade Plays a Crucial Role for Cardiac Remodeling in Senescence-Accelerated Prone Mice. / 2016 / PubMed / Full text
• DAMPs and influenza virus infection in ageing. / 11.2015 / PubMed / Full text
• Decreased serum level of HMGB1 and MyD88 during human aging progress in healthy individuals. / 04.2016 / PubMed / Full text
• [Peptides and [[CCL11]] and HMGB1 as molecular markers of aging: literature review and own data]. / 2014 / PubMed
• HMGB1 facilitates repair of mitochondrial DNA damage and extends the lifespan of mutant ataxin-1 knock-in mice. / 01.2015 / PubMed / Full text
• Secondhand smoke exposure-induced nucleocytoplasmic shuttling of HMGB1 in a rat premature skin aging model. / 02.01.2015 / PubMed / Full text
• Changes in the expression of the Toll-like receptor system in the aging rat kidneys. / 2014 / PubMed / Full text
• Brain innate immunity in the regulation of neuroinflammation: therapeutic strategies by modulating CD200-CD200R interaction involve the cannabinoid system. / 2014 / PubMed / Full text

KL

• The goddess who spins the thread of life: Klotho, psychiatric stress, and accelerated aging. / 08.2019 / PubMed / Full text
• [i]KLOTHO[/i] heterozygosity attenuates [i]APOE4[/i]-related amyloid burden in preclinical AD. / 16.04.2019 / PubMed / Full text
• Utilizing Atlas-Based Modeling to Predict Knee Joint Cartilage Degeneration: Data from the Osteoarthritis Initiative. / 03.2019 / PubMed / Full text
• Impaired proteostasis in senescent vascular endothelial cells: a perspective on estrogen and oxidative stress in the aging vasculature. / 01.02.2019 / PubMed / Full text
• Leukocyte Telomere Length in Patients with Radiographic Knee Osteoarthritis. / 04.2019 / PubMed / Full text
• Klotho at the Edge of Alzheimer's Disease and Senile Depression. / 03.2019 / PubMed / Full text
• Review and meta-analysis of genetic polymorphisms associated with exceptional human longevity. / 10.2018 / PubMed / Full text
• G-395A polymorphism in the promoter region of the KLOTHO gene associates with frailty among the oldest-old. / 30.04.2018 / PubMed / Full text
• Protective Effect of Klotho against Ischemic Brain Injury Is Associated with Inhibition of RIG-I/NF-κB Signaling. / 2017 / PubMed / Full text
• Changes in expression of klotho affect physiological processes, diseases, and cancer. / 01.2018 / PubMed / Full text
• Anti-aging factor, serum alpha-Klotho, as a marker of acute physiological stress, and a predictor of ICU mortality, in patients with septic shock. / 04.2018 / PubMed / Full text
• Secreted αKlotho isoform protects against age-dependent memory deficits. / 09.2018 / PubMed / Full text
• Induction of anti-aging gene klotho with a small chemical compound that demethylates CpG islands. / 18.07.2017 / PubMed / Full text
• Longevity Klotho gene polymorphism and the risk of dementia in older men. / 07.2017 / PubMed / Full text
• Klotho, APOEε4, cognitive ability, brain size, atrophy, and survival: a study in the Aberdeen Birth Cohort of 1936. / 07.2017 / PubMed / Full text
• The relevance of α-KLOTHO to the central nervous system: Some key questions. / 07.2017 / PubMed / Full text
• Systemic klotho is associated with KLOTHO variation and predicts intrinsic cortical connectivity in healthy human aging. / 04.2017 / PubMed / Full text
• Activation of SIRT1 Attenuates Klotho Deficiency-Induced Arterial Stiffness and Hypertension by Enhancing AMP-Activated Protein Kinase Activity. / 11.2016 / PubMed / Full text
• The FGF23/KLOTHO Regulatory Network and Its Roles in Human Disorders. / 2016 / PubMed / Full text
• Antiaging Gene Klotho Deficiency Promoted High-Fat Diet-Induced Arterial Stiffening via Inactivation of AMP-Activated Protein Kinase. / 03.2016 / PubMed / Full text
• KL-optimal experimental design for discriminating between two growth models applied to a beef farm. / 02.2016 / PubMed / Full text
• Secreted and Transmembrane αKlotho Isoforms Have Different Spatio-Temporal Profiles in the Brain during Aging and Alzheimer's Disease Progression. / 2015 / PubMed / Full text
• Genetic Variants in KLOTHO Associate With Cognitive Function in the Oldest Old Group. / 09.2016 / PubMed / Full text
• N-ethyl-N-Nitrosourea (ENU) induced mutations within the klotho gene lead to ectopic calcification and reduced lifespan in mouse models. / 2015 / PubMed / Full text
• Senescence-inducible LEC2 enhances triacylglycerol accumulation in leaves without negatively affecting plant growth. / 12.2015 / PubMed / Full text
• Molecular basis of Klotho: from gene to function in aging. / 04.2015 / PubMed / Full text
• Life extension factor klotho enhances cognition. / 22.05.2014 / PubMed / Full text

TFAM

• Late life maintenance and enhancement of functional exercise capacity in low and high responding rats after low intensity treadmill training. / 01.10.2019 / PubMed / Full text
• Maternal ageing impairs mitochondrial DNA kinetics during early embryogenesis in mice. / 08.07.2019 / PubMed / Full text
• Differences in Liver TFAM Binding to mtDNA and mtDNA Damage between Aged and Extremely Aged Rats. / 27.05.2019 / PubMed / Full text
• Photobiomodulation and Coenzyme Q Treatments Attenuate Cognitive Impairment Associated With Model of Transient Global Brain Ischemia in Artificially Aged Mice. / 2019 / PubMed / Full text
• [A study on alterations in mitochondrial biological characteristics during cellular senescence of human embryonic lung fibroblasts]. / 06.03.2019 / PubMed / Full text
• Changes in Stemness Properties, Differentiation Potential, Oxidative Stress, Senescence and Mitochondrial Function in Wharton's Jelly Stem Cells of Umbilical Cords of Mothers with Gestational Diabetes Mellitus. / 06.2019 / PubMed / Full text
• Cycling CD4 T cells in HIV-infected immune nonresponders have mitochondrial dysfunction. / 01.11.2018 / PubMed / Full text
• Increased TFAM binding to mtDNA damage hot spots is associated with mtDNA loss in aged rat heart. / 20.08.2018 / PubMed / Full text
• Restoring mitochondrial DNA copy number preserves mitochondrial function and delays vascular aging in mice. / 08.2018 / PubMed / Full text
• Sestrin2 prevents age-related intolerance to post myocardial infarction via AMPK/PGC-1α pathway. / 02.2018 / PubMed / Full text
• Skeletal muscle from aged American Quarter Horses shows impairments in mitochondrial biogenesis and expression of autophagy markers. / 02.2018 / PubMed / Full text
• Dietary supplementation with acetyl-l-carnitine counteracts age-related alterations of mitochondrial biogenesis, dynamics and antioxidant defenses in brain of old rats. / 11.2017 / PubMed / Full text
• Effect of lifelong football training on the expression of muscle molecular markers involved in healthy longevity. / 04.2017 / PubMed / Full text
• Regulation of mitochondrial gene expression, the epigenetic enigma. / 01.03.2017 / PubMed / Full text
• Poor embryo development in post-ovulatory in vivo-aged mouse oocytes is associated with mitochondrial dysfunction, but mitochondrial transfer from somatic cells is not sufficient for rejuvenation. / 10.2016 / PubMed / Full text
• Disentangling the effect of dietary restriction on mitochondrial function using recombinant inbred mice. / 05.11.2017 / PubMed / Full text
• "What makes some rats live so long?" The mitochondrial contribution to longevity through balance of mitochondrial dynamics and mtDNA content. / 01.12.2016 / PubMed / Full text
• Response of BAX, Bcl-2 Proteins, and SIRT1/PGC-1α mRNA Expression to 8-Week Treadmill Running in the Aging Rat Skeletal Muscle. / 2016 / PubMed / Full text
• Methylene blue improves sensorimotor phenotype and decreases anxiety in parallel with activating brain mitochondria biogenesis in mid-age mice. / 12.2016 / PubMed / Full text
• HIF-1 regulates insect lifespan extension by inhibiting c-Myc-TFAM signaling and mitochondrial biogenesis. / 11.2016 / PubMed / Full text
• Resistance exercise training and in vitro skeletal muscle oxidative capacity in older adults. / 07.2016 / PubMed / Full text
• Mitochondrial Lon protease in human disease and aging: Including an etiologic classification of Lon-related diseases and disorders. / 11.2016 / PubMed / Full text
• Resveratrol attenuates senescence of adipose-derived mesenchymal stem cells and restores their paracrine effects on promoting insulin secretion of INS-1 cells through Pim-1. / 2016 / PubMed
• Regulation of mitochondrial biogenesis through TFAM-mitochondrial DNA interactions: Useful insights from aging and calorie restriction studies. / 11.2015 / PubMed / Full text
• Dietary Tocotrienol/γ-Cyclodextrin Complex Increases Mitochondrial Membrane Potential and ATP Concentrations in the Brains of Aged Mice. / 2015 / PubMed / Full text
• A comparison among the tissue-specific effects of aging and calorie restriction on TFAM amount and TFAM-binding activity to mtDNA in rat. / 07.2014 / PubMed / Full text
• Partial reversal of skeletal muscle aging by restoration of normal NAD⁺ levels. / 02.2014 / PubMed / Full text

ASL

• Increased blood-brain barrier permeability to water in the aging brain detected using noninvasive multi-TE ASL MRI. / 01.2021 / PubMed / Full text
• Quantitative Cerebrovascular Reactivity in Normal Aging: Comparison Between Phase-Contrast and Arterial Spin Labeling MRI. / 2020 / PubMed / Full text
• Correcting Task fMRI Signals for Variability in Baseline CBF Improves BOLD-Behavior Relationships: A Feasibility Study in an Aging Model. / 2020 / PubMed / Full text
• Cerebral Blood Flow in Community-Based Older Twins Is Moderately Heritable: An Arterial Spin Labeling Perfusion Imaging Study. / 2019 / PubMed / Full text
• A longitudinal characterization of perfusion in the aging brain and associations with cognition and neural structure. / 15.08.2019 / PubMed / Full text
• Cortical cerebral blood flow in ageing: effects of haematocrit, sex, ethnicity and diabetes. / 10.2019 / PubMed / Full text
• Exercise-stimulated arterial transit time in calf muscles measured by dynamic contrast-enhanced magnetic resonance imaging. / 01.2019 / PubMed / Full text
• Impact of Coffee, Wine, and Chocolate Consumption on Cognitive Outcome and MRI Parameters in Old Age. / 01.10.2018 / PubMed / Full text
• Potential Role of OERP as Early Marker of Mild Cognitive Impairment. / 2018 / PubMed / Full text
• Reduced Regional Cerebral Blood Flow Relates to Poorer Cognition in Older Adults With Type 2 Diabetes. / 2018 / PubMed / Full text
• The Age-Related Perfusion Pattern Measured With Arterial Spin Labeling MRI in Healthy Subjects. / 2018 / PubMed / Full text
• Resilience and amygdala function in older healthy and depressed adults. / 09.2018 / PubMed / Full text
• Does Aerobic Exercise Influence Intrinsic Brain Activity? An Aerobic Exercise Intervention among Healthy Old Adults. / 2017 / PubMed / Full text
• Cerebral blood flow and vasoreactivity in aging: an arterial spin labeling study. / 23.03.2017 / PubMed / Full text
• Cerebral blood flow measured by arterial spin labeling MRI at resting state in normal aging and Alzheimer's disease. / 01.2017 / PubMed / Full text
• Cerebral blood flow MRI in the nondemented elderly is not predictive of post-operative delirium but is correlated with cognitive performance. / 04.2017 / PubMed / Full text
• Improving drug retention in liposomes by aging with the aid of glucose. / 30.05.2016 / PubMed / Full text
• The Utility of Cerebral Blood Flow as a Biomarker of Preclinical Alzheimer's Disease. / 03.2016 / PubMed / Full text
• Long-term effect of orthokeratology on the anterior segment length. / 08.2016 / PubMed / Full text
• Comparison of long-labeled pseudo-continuous arterial spin labeling (ASL) features between young and elderly adults: special reference to parameter selection. / 01.2017 / PubMed / Full text
• Assessing intracranial vascular compliance using dynamic arterial spin labeling. / 01.01.2016 / PubMed / Full text
• Lens Position and Age: The Central India Eye and Medical Study. / 08.2015 / PubMed / Full text
• Age-related changes in brain hemodynamics; A calibrated MRI study. / 10.2015 / PubMed / Full text
• Characterizing the white matter hyperintensity penumbra with cerebral blood flow measures. / 2015 / PubMed / Full text
• Tissue specific arterial spin labeling fMRI: a superior method for imaging cerebral blood flow in aging and disease. / 2014 / PubMed / Full text
• Metabolic and transcriptional response to a high-fat diet in Drosophila melanogaster. / 02.2014 / PubMed / Full text

BRCA1

• Epigenome-wide exploratory study of monozygotic twins suggests differentially methylated regions to associate with hand grip strength. / 10.2019 / PubMed / Full text
• PML nuclear bodies are recruited to persistent DNA damage lesions in an RNF168-53BP1 dependent manner and contribute to DNA repair. / 06.2019 / PubMed / Full text
• Mechanistic link between DNA damage sensing, repairing and signaling factors and immune signaling. / 2019 / PubMed / Full text
• Klotho gene polymorphisms are associated with healthy aging and longevity: Evidence from a meta-analysis. / 03.2019 / PubMed / Full text
• High expression of the breast cancer susceptibility gene BRCA1 in long-lived termite kings. / 11.10.2018 / PubMed / Full text
• The activated DNA double-strand break repair pathway in cumulus cells from aging patients may be used as a convincing predictor of poor outcomes after in vitro fertilization-embryo transfer treatment. / 2018 / PubMed / Full text
• Cost effectiveness of population based BRCA1 founder mutation testing in Sephardi Jewish women. / 04.2018 / PubMed / Full text
• Replication Stress Shapes a Protective Chromatin Environment across Fragile Genomic Regions. / 04.01.2018 / PubMed / Full text
• Faulty BRCA1, BRCA2 genes: how poor is the prognosis? / 10.2017 / PubMed / Full text
• Ovarian Aging in Women With BRCA Germline Mutations. / 01.10.2017 / PubMed / Full text
• The expected benefit of preventive mastectomy on breast cancer incidence and mortality in BRCA mutation carriers, by age at mastectomy. / 01.2018 / PubMed / Full text
• A BRCA1-Dependent DNA Damage Response in the Regenerating Adult Peripheral Nerve Milieu. / 05.2018 / PubMed / Full text
• The Histone Variant MacroH2A1 Is a BRCA1 Ubiquitin Ligase Substrate. / 30.05.2017 / PubMed / Full text
• A Multigene Test Could Cost-Effectively Help Extend Life Expectancy for Women at Risk of Hereditary Breast Cancer. / 04.2017 / PubMed / Full text
• Serum AMH levels in healthy women from BRCA1/2 mutated families: are they reduced? / 11.2016 / PubMed / Full text
• p16INK4a suppresses BRCA1-deficient mammary tumorigenesis. / 20.12.2016 / PubMed / Full text
• BRCA-1 Gene Expression and Comparative Proteomic Profile of Primordial Follicles from Young and Adult Buffalo (Bubalus bubalis) Ovaries. / 03.04.2017 / PubMed / Full text
• Women's preferences for contralateral prophylactic mastectomy: An investigation using protection motivation theory. / 05.2016 / PubMed / Full text
• Accelerated geroncogenesis in hereditary breast-ovarian cancer syndrome. / 15.03.2016 / PubMed / Full text
• Genetic suppression reveals DNA repair-independent antagonism between BRCA1 and COBRA1 in mammary gland development. / 04.03.2016 / PubMed / Full text
• Large-scale genomic analyses link reproductive aging to hypothalamic signaling, breast cancer susceptibility and BRCA1-mediated DNA repair. / 11.2015 / PubMed / Full text
• Comparative proteomic analysis of primordial follicles from ovaries of immature and aged rats. / 2015 / PubMed / Full text
• BRCA Mutations, DNA Repair Deficiency, and Ovarian Aging. / 09.2015 / PubMed / Full text
• Increased DNA damage and repair deficiency in granulosa cells are associated with ovarian aging in rhesus monkey. / 07.2015 / PubMed / Full text
• Conservation of pro-longevity genes among mammals. / 03.2015 / PubMed / Full text
• Targeting of DNA Damage Signaling Pathway Induced Senescence and Reduced Migration of Cancer cells. / 06.2015 / PubMed / Full text

C5

• The C5-75 Program: Meeting the Need for Efficient, Pragmatic Frailty Screening and Management in Primary Care. / 23.06.2020 / PubMed / Full text
• Can a relatively large spinal cord for the dural sac influence severity of paralysis in elderly patients with cervical spinal cord injury caused by minor trauma? / 26.06.2020 / PubMed / Full text
• Age and Sex-Associated Changes of Complement Activity and Complement Levels in a Healthy Caucasian Population. / 2018 / PubMed / Full text
• Longevity of adenovirus vector immunity in mice and its implications for vaccine efficacy. / 29.10.2018 / PubMed / Full text
• Generating Rasch-based activity of daily living measures from the Spinal Cord Injury Longitudinal Aging Study. / 01.2018 / PubMed / Full text
• A Large Cohort Study of 18F Fluoro-Deoxy-Glucose Uptake in Normal Spinal Cord: Quantitative Assessment of the Contamination From Adjacent Vertebral Marrow Uptake and Validity of Normalizing the Cord Uptake Against the Lumbar Thecal Sac. / 01.2017 / PubMed / Full text
• Demographic aspects in cervical vertebral bodies' size and shape (C3-C7): a skeletal study. / 01.2017 / PubMed / Full text
• Tract-specific and age-related variations of the spinal cord microstructure: a multi-parametric MRI study using diffusion tensor imaging (DTI) and inhomogeneous magnetization transfer (ihMT). / 06.2016 / PubMed / Full text
• Age-related brain atrophy may be mitigated by internal jugular vein enlargement in male individuals without neurologic disease. / 03.2017 / PubMed / Full text
• The incidence of cervical spondylosis decreases with aging in the elderly, and increases with aging in the young and adult population: a hospital-based clinical analysis. / 2016 / PubMed / Full text
• Signal intensity loss of the intervertebral discs in the cervical spine of young patients on fluid sensitive sequences. / 03.2016 / PubMed / Full text
• Are the standard parameters of cervical spine alignment and range of motion related to age, sex, and cervical disc degeneration? / 09.2015 / PubMed / Full text
• DBA/2J genetic background exacerbates spontaneous lethal seizures but lessens amyloid deposition in a mouse model of Alzheimer's disease. / 2015 / PubMed / Full text
• Permeability and shear modulus of articular cartilage in growing mice. / 02.2016 / PubMed / Full text
• Acute exercise increases hippocampal TNF-α, Caspase-3 and Caspase-7 expression in healthy young and older mice. / 04.2015 / PubMed
• Age influences inflammatory responses, hemodynamics, and cardiac proteasome activation during acute lung injury. / 05.2015 / PubMed / Full text
• Minocycline enhances hippocampal memory, neuroplasticity and synapse-associated proteins in aged C57 BL/6 mice. / 05.2015 / PubMed / Full text
• Presence of rd8 mutation does not alter the ocular phenotype of late-onset retinal degeneration mouse model. / 2015 / PubMed / Full text
• Concentration- and age-dependent effects of chronic caffeine on contextual fear conditioning in C57BL/6J mice. / 01.02.2016 / PubMed / Full text
• Miglitol protects against age-dependent weight gain in mice: A potential role of increased UCP1 content in brown adipose tissue. / 2015 / PubMed / Full text
• Cathelicidin related antimicrobial peptide, laminin, Toll-like receptors and chemokines levels in experimental hypersensitivity pneumonitis in mice. / 06.2015 / PubMed / Full text
• A mutation in the NADH-dehydrogenase subunit 2 suppresses fibroblast aging. / 20.04.2015 / PubMed / Full text
• Anti-skin ageing activity of napthoquinones from Arnebia nobilis Reichb.f. / 2016 / PubMed / Full text
• Altered neutrophil functions in elderly patients during a 6-month follow-up period after a hip fracture. / 05.2015 / PubMed / Full text
• Age-associated oxidative modifications of mitochondrial α-subunit of F1 ATP synthase from mouse skeletal muscles. / 2015 / PubMed / Full text
• Videofluoroscopic Validation of a Translational Murine Model of Presbyphagia. / 06.2015 / PubMed / Full text

COMT

• The geriatric pain experience in mice: intact cutaneous thresholds but altered responses to tonic and chronic pain. / 05.2020 / PubMed / Full text
• A candidate gene study of risk for dementia in older, postmenopausal women: Results from the Women's Health Initiative Memory Study. / 05.2019 / PubMed / Full text
• Frontoparietal cortical thickness mediates the effect of COMT Val Met polymorphism on age-associated executive function. / 01.2019 / PubMed / Full text
• [MELATONIN: THE POSSIBILITY TO ANALYSE THE MARKER OF AGE-RELATED PATHOLOGY IN THE BUCCAL EPITHELIUM AND URINE]. / 2017 / PubMed
• The Moderating Role of COMT and BDNF Polymorphisms on Transfer Effects Following Multi- and Single-Domain Cognitive Training Among Community-Dwelling Shanghainese Older Adults. / 2018 / PubMed / Full text
• Genetic Risk for Age-Related Cognitive Impairment Does Not Predict Cognitive Performance in Middle Age. / 2018 / PubMed / Full text
• Dopamine-Related Genotypes and Physical Activity Change During an Intervention: The Lifestyle Interventions and Independence for Elders Study. / 07.2018 / PubMed / Full text
• Genetic Biomarkers on Age-Related Cognitive Decline. / 2017 / PubMed / Full text
• A genetic variant in the catechol-O-methyl transferase (COMT) gene is related to age-dependent differences in the therapeutic effect of calcium-channel blockers. / 07.2017 / PubMed / Full text
• Catechol-O-Methyltransferase Genotype and Gait Speed Changes over 10 Years in Older Adults. / 09.2017 / PubMed / Full text
• [Melatonin as a molecular marker of age-related pathologies]. / 2017 / PubMed
• Chloroplast overexpression of rice caffeic acid O-methyltransferase increases melatonin production in chloroplasts via the 5-methoxytryptamine pathway in transgenic rice plants. / 08.2017 / PubMed / Full text
• Age-dependent role of pre- and perinatal factors in interaction with genes on ADHD symptoms across adolescence. / 07.2017 / PubMed / Full text
• Age differences in arterial and venous extra-cerebral blood flow in healthy adults: contributions of vascular risk factors and genetic variants. / 08.2017 / PubMed / Full text
• Executive function performance and change in aging is predicted by apolipoprotein E, intensified by catechol-O-methyltransferase and brain-derived neurotrophic factor, and moderated by age and lifestyle. / 04.2017 / PubMed / Full text
• Age-Dependent Effects of Catechol-O-Methyltransferase (COMT) Gene Val158Met Polymorphism on Language Function in Developing Children. / 01.01.2017 / PubMed / Full text
• Aging and the genetic road towards the positivity effect in memory. / 09.2016 / PubMed / Full text
• Older age may offset genetic influence on affect: The COMT polymorphism and affective well-being across the life span. / 05.2016 / PubMed / Full text
• Differential effect of age on posterior and anterior hippocampal functional connectivity. / 06.2016 / PubMed / Full text
• Pulse Pressure Magnifies the Effect of COMT Val(158)Met on 15 Years Episodic Memory Trajectories. / 2016 / PubMed / Full text
• Modulative effects of COMT haplotype on age-related associations with brain morphology. / 06.2016 / PubMed / Full text
• COMT Val158Met polymorphism is associated with blood pressure and lipid levels in general families of Bama longevous area in China. / 2015 / PubMed / Full text
• Genetic Basis of the Relationship Between Reproduction and Longevity: A Study on Common Variants of Three Genes in Steroid Hormone Metabolism--CYP17, HSD17B1, and COMT. / 10.2015 / PubMed / Full text
• Cognitive ability, intraindividual variability, and common genetic variants of catechol-O-methyltransferase and brain-derived neurotrophic factor: a longitudinal study in a population-based sample of older adults. / 06.2014 / PubMed / Full text
• Healthy aging increases the cognitive effects of two genes that influence extracellular dopamine. / 06.2014 / PubMed / Full text
• BDNF and COMT polymorphisms have a limited association with episodic memory performance or engagement in complex cognitive activity in healthy older adults. / 04.2014 / PubMed / Full text

LRRK2

• Accelerated telomere shortening independent of LRRK2 variants in Chinese patients with Parkinson's disease. / 29.10.2020 / PubMed / Full text
• The effect of LRRK2 loss-of-function variants in humans. / 06.2020 / PubMed / Full text
• Parkinson's disease-related Leucine-rich repeat kinase 2 modulates nuclear morphology and genomic stability in striatal projection neurons during aging. / 19.02.2020 / PubMed / Full text
• Autophagy and LRRK2 in the Aging Brain. / 2019 / PubMed / Full text
• SerThr-PhosphoProteome of Brain from Aged PINK1-KO A53T-SNCA Mice Reveals pT1928-MAP1B and pS3781-ANK2 Deficits, as Hub between Autophagy and Synapse Changes. / 04.07.2019 / PubMed / Full text
• Age-dependent accumulation of oligomeric SNCA/α-synuclein from impaired degradation in mutant LRRK2 knockin mouse model of Parkinson disease: role for therapeutic activation of chaperone-mediated autophagy (CMA). / 02.2020 / PubMed / Full text
• A Neuron-Glial Trans-Signaling Cascade Mediates LRRK2-Induced Neurodegeneration. / 12.02.2019 / PubMed / Full text
• Upregulation of the p53-p21 pathway by G2019S LRRK2 contributes to the cellular senescence and accumulation of α-synuclein. / 02.2019 / PubMed / Full text
• G2019S LRRK2 mutation facilitates α-synuclein neuropathology in aged mice. / 12.2018 / PubMed / Full text
• The Enzymatic Core of the Parkinson's Disease-Associated Protein LRRK2 Impairs Mitochondrial Biogenesis in Aging Yeast. / 2018 / PubMed / Full text
• Age-related pathology after adenoviral overexpression of the leucine-rich repeat kinase 2 in the mouse striatum. / 06.2018 / PubMed / Full text
• LRRK2 G2019S Induces Anxiety/Depression-like Behavior before the Onset of Motor Dysfunction with 5-HT Receptor Upregulation in Mice. / 14.02.2018 / PubMed / Full text
• Age-Dependent Dopaminergic Neurodegeneration and Impairment of the Autophagy-Lysosomal Pathway in LRRK-Deficient Mice. / 15.11.2017 / PubMed / Full text
• Initial elevations in glutamate and dopamine neurotransmission decline with age, as does exploratory behavior, in LRRK2 G2019S knock-in mice. / 20.09.2017 / PubMed / Full text
• Suppression of neuroinflammation by matrix metalloproteinase-8 inhibitor in aged normal and LRRK2 G2019S Parkinson's disease model mice challenged with lipopolysaccharide. / 18.11.2017 / PubMed / Full text
• Progression of pathology in PINK1-deficient mouse brain from splicing via ubiquitination, ER stress, and mitophagy changes to neuroinflammation. / 02.08.2017 / PubMed / Full text
• Age-dependent dopamine transporter dysfunction and Serine129 phospho-α-synuclein overload in G2019S LRRK2 mice. / 14.03.2017 / PubMed / Full text
• Combined LRRK2 mutation, aging and chronic low dose oral rotenone as a model of Parkinson's disease. / 18.01.2017 / PubMed / Full text
• LRRK2 BAC transgenic rats develop progressive, L-DOPA-responsive motor impairment, and deficits in dopamine circuit function. / 01.03.2016 / PubMed / Full text
• Functional and Morphological Correlates in the Drosophila LRRK2 loss-of-function Model of Parkinson's Disease: Drug Effects of Withania somnifera (Dunal) Administration. / 2016 / PubMed / Full text
• G2019S LRRK2 and aging confer susceptibility to proteasome inhibitor-induced neurotoxicity in nigrostriatal dopaminergic system. / 12.2015 / PubMed / Full text
• An early axonopathy in a hLRRK2(R1441G) transgenic model of Parkinson disease. / 10.2015 / PubMed / Full text
• Mutations in LRRK2 potentiate age-related impairment of autophagic flux. / 11.07.2015 / PubMed / Full text
• [11C]PBR28 PET imaging is sensitive to neuroinflammation in the aged rat. / 08.2015 / PubMed / Full text
• Changes in actin dynamics and F-actin structure both in synaptoneurosomes of LRRK2(R1441G) mutant mice and in primary human fibroblasts of LRRK2(G2019S) mutation carriers. / 22.01.2015 / PubMed / Full text
• Genetic and pharmacological evidence that G2019S LRRK2 confers a hyperkinetic phenotype, resistant to motor decline associated with aging. / 11.2014 / PubMed / Full text

MDM2

• SENEBLOC, a long non-coding RNA suppresses senescence via p53-dependent and independent mechanisms. / 06.04.2020 / PubMed / Full text
• Disruption of Robo2-Baiap2 integrated signaling drives cystic disease. / 19.09.2019 / PubMed / Full text
• Senescence-induced immunophenotype, gene expression and electrophysiology changes in human amniocytes. / 11.2019 / PubMed / Full text
• Hsp90β interacts with MDM2 to suppress p53-dependent senescence during skeletal muscle regeneration. / 10.2019 / PubMed / Full text
• TZAP plays an inhibitory role in the self-renewal of porcine mesenchymal stromal cells and is implicated the regulation of premature senescence via the p53 pathway. / 07.03.2019 / PubMed / Full text
• Synaptotagmin-7, a binding protein of P53, inhibits the senescence and promotes the tumorigenicity of lung cancer cells. / 28.02.2019 / PubMed / Full text
• The SCF ubiquitin ligase complex mediates degradation of the tumor suppressor FBXO31 and thereby prevents premature cellular senescence. / 19.10.2018 / PubMed / Full text
• The Dysfunctional MDM2-p53 Axis in Adipocytes Contributes to Aging-Related Metabolic Complications by Induction of Lipodystrophy. / 11.2018 / PubMed / Full text
• Effect of CCNB1 silencing on cell cycle, senescence, and apoptosis through the p53 signaling pathway in pancreatic cancer. / 01.2018 / PubMed / Full text
• Boosting ATM activity alleviates aging and extends lifespan in a mouse model of progeria. / 02.05.2018 / PubMed / Full text
• Acute HSF1 depletion induces cellular senescence through the MDM2-p53-p21 pathway in human diploid fibroblasts. / 08.05.2018 / PubMed / Full text
• Relevance of the p53-MDM2 axis to aging. / 01.2018 / PubMed / Full text
• Pomegranate peel extract attenuates D-galactose-induced oxidative stress and hearing loss by regulating PNUTS/PP1 activity in the mouse cochlea. / 11.2017 / PubMed / Full text
• Melatonin regulates the aging mouse hippocampal homeostasis via the sirtuin1-FOXO1 pathway. / 2017 / PubMed / Full text
• Monitoring p53 by MDM2 and MDMX is required for endocrine pancreas development and function in a spatio-temporal manner. / 01.03.2017 / PubMed / Full text
• Protection against High-Fat-Diet-Induced Obesity in MDM2 Mice Due to Reduced p53 Activity and Enhanced Energy Expenditure. / 24.01.2017 / PubMed / Full text
• Pathways of aging: comparative analysis of gene signatures in replicative senescence and stress induced premature senescence. / 28.12.2016 / PubMed / Full text
• Roles of TP53 in determining therapeutic sensitivity, growth, cellular senescence, invasion and metastasis. / 01.2017 / PubMed / Full text
• Dynamics of ARF regulation that control senescence and cancer. / 11.2016 / PubMed / Full text
• Breaking a paradigm: IL-6/STAT3 signaling suppresses metastatic prostate cancer upon ARF expression. / 03.2016 / PubMed / Full text
• Combined therapies that induce senescence and stabilize p53 block melanoma growth and prompt antitumor immune responses. / 08.2015 / PubMed / Full text
• BI2536--A PLK inhibitor augments paclitaxel efficacy in suppressing tamoxifen induced senescence and resistance in breast cancer cells. / 08.2015 / PubMed / Full text
• NQO1 Stabilizes p53 in Response to Oncogene-Induced Senescence. / 2015 / PubMed / Full text
• MDM2 turnover and expression of ATRX determine the choice between quiescence and senescence in response to CDK4 inhibition. / 10.04.2015 / PubMed / Full text
• Senescence induction in renal carcinoma cells by Nutlin-3: a potential therapeutic strategy based on MDM2 antagonism. / 28.10.2014 / PubMed / Full text
• Germline genetics of the p53 pathway affect longevity in a gender specific manner. / 2014 / PubMed / Full text

SIRT2

• Melatonin ameliorates the advanced maternal age-associated meiotic defects in oocytes through the SIRT2-dependent H4K16 deacetylation pathway. / 24.01.2020 / PubMed / Full text
• SIRT2 functions in aging, autophagy, and apoptosis in post-maturation bovine oocytes. / 01.09.2019 / PubMed / Full text
• Lifelong Football Training: Effects on Autophagy and Healthy Longevity Promotion. / 2019 / PubMed / Full text
• Mitochondrial Stress-Initiated Aberrant Activation of the NLRP3 Inflammasome Regulates the Functional Deterioration of Hematopoietic Stem Cell Aging. / 22.01.2019 / PubMed / Full text
• Hsp90 Stabilizes SIRT1 Orthologs in Mammalian Cells and [i]C. elegans[/i]. / 20.11.2018 / PubMed / Full text
• Tenovin-1 Induces Senescence and Decreases Wound-Healing Activity in Cultured Rat Primary Astrocytes. / 01.05.2019 / PubMed / Full text
• High expression of CPT1b in skeletal muscle in metabolically healthy older subjects. / 04.2019 / PubMed / Full text
• Expression of Sirtuins in the Retinal Neurons of Mice, Rats, and Humans. / 2017 / PubMed / Full text
• Loss of SIRT2 leads to axonal degeneration and locomotor disability associated with redox and energy imbalance. / 12.2017 / PubMed / Full text
• SIRT2 Acts as a Cardioprotective Deacetylase in Pathological Cardiac Hypertrophy. / 21.11.2017 / PubMed / Full text
• Molecular evolutionary patterns of NAD /Sirtuin aging signaling pathway across taxa. / 2017 / PubMed / Full text
• Sirtuins and Their Roles in Brain Aging and Neurodegenerative Disorders. / 03.2017 / PubMed / Full text
• Resistance training and redox homeostasis: Correlation with age-associated genomic changes. / 12.2016 / PubMed / Full text
• Aging-related 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-induced neurochemial and behavioral deficits and redox dysfunction: improvement by AK-7. / 09.2016 / PubMed / Full text
• Increased expression of SIRT2 is a novel marker of cellular senescence and is dependent on wild type p53 status. / 17.07.2016 / PubMed / Full text
• Effects of intrinsic aerobic capacity, aging and voluntary running on skeletal muscle sirtuins and heat shock proteins. / 15.06.2016 / PubMed / Full text
• Sirtuins, Cell Senescence, and Vascular Aging. / 05.2016 / PubMed / Full text
• The expression levels of the sirtuins in patients with BCC. / 05.2016 / PubMed / Full text
• Effects of Aging and Cardiovascular Disease Risk Factors on the Expression of Sirtuins in the Human Corpus Cavernosum. / 11.2015 / PubMed / Full text
• Localization of sirtuins (SIRT1-7) in the aged mouse inner ear. / 2016 / PubMed / Full text
• Aging-related rotenone-induced neurochemical and behavioral deficits: role of SIRT2 and redox imbalance, and neuroprotection by AK-7. / 2015 / PubMed / Full text
• Differential expression of sirtuins in the aging rat brain. / 2015 / PubMed / Full text
• Polymorphisms Falling Within Putative miRNA Target Sites in the 3'UTR Region of SIRT2 and DRD2 Genes Are Correlated With Human Longevity. / 05.2016 / PubMed / Full text
• The role of melatonin, sirtuin2 and FoXO1 transcription factor in the aging process of colon in male rats. / 02.2015 / PubMed / Full text
• [[[SIRT2]], a multi-talented deacetylase]. / 05.2014 / PubMed / Full text
• SIRT2 induces the checkpoint kinase BubR1 to increase lifespan. / 01.07.2014 / PubMed / Full text

APC

• Differences between blacks and whites in well-being, beliefs, emotional states, behaviors and survival, 1978-2014. / 2020 / PubMed / Full text
• Wnt-induced, TRP53-mediated Cell Cycle Arrest of Precursors Underlies Interstitial Cell of Cajal Depletion During Aging. / 07.08.2020 / PubMed / Full text
• Burden of musculoskeletal disorders in Iran during 1990-2017: estimates from the Global Burden of Disease Study 2017. / 10.07.2020 / PubMed / Full text
• Fall-related mortality trends in older Japanese adults aged ≥65 years: a nationwide observational study. / 11.12.2019 / PubMed / Full text
• Stroke Mortality Rates and Trends in Romania, 1994-2017. / 12.2019 / PubMed / Full text
• A new approach to quantifying the EEG during walking: Initial evidence of gait related potentials and their changes with aging and dual tasking. / 15.10.2019 / PubMed / Full text
• Risk-period-cohort approach for averting identification problems in longitudinal models. / 2019 / PubMed / Full text
• Wnt Signaling Mediates the Aging-Induced Differentiation Impairment of Intestinal Stem Cells. / 06.2019 / PubMed / Full text
• Biased estimation of trends in cohort effects: the problems with age-period-cohort models in ecology. / 12.2018 / PubMed / Full text
• [Gender Differences in Projected Life Expectancy in Japan (2023-2047) Determined by Bayesian Age-Period-Cohort Analysis]. / 2018 / PubMed / Full text
• Activated Yes-Associated Protein Accelerates Cell Cycle, Inhibits Apoptosis, and Delays Senescence in Human Periodontal Ligament Stem Cells. / 2018 / PubMed / Full text
• Activating the Anaphase Promoting Complex to Enhance Genomic Stability and Prolong Lifespan. / 27.06.2018 / PubMed / Full text
• Effect of senescence marker protein 30 on the proliferation and apoptosis of human lens epithelial cells SRA01/04. / 2018 / PubMed / Full text
• [Role and alterations of DNA methylation during the aging and cancer]. / 01.2018 / PubMed / Full text
• MicroRNA-210-mediated proliferation, survival, and angiogenesis promote cardiac repair post myocardial infarction in rodents. / 12.2017 / PubMed / Full text
• IL-6 Production by TLR-Activated APC Broadly Enhances Aged Cognate CD4 Helper and B Cell Antibody Responses In Vivo. / 01.04.2017 / PubMed / Full text
• Standard expected years of life lost due to tuberculosis in Poland. / 01.02.2017 / PubMed / Full text
• The effects of New York City's coordinated public health programmes on mortality through 2011. / 01.08.2017 / PubMed / Full text
• Regional variation in coronary heart disease mortality trends in Portugal, 1981-2012. / 01.12.2016 / PubMed / Full text
• Mitotic degradation of yeast Fkh1 by the Anaphase Promoting Complex is required for normal longevity, genomic stability and stress resistance. / 04.2016 / PubMed / Full text
• Breast Cancer Trend in Iran from 2000 to 2009 and Prediction till 2020 using a Trend Analysis Method. / 2016 / PubMed / Full text
• Secular trend analysis of lung cancer incidence in Sihui city, China between 1987 and 2011. / 31.07.2015 / PubMed / Full text
• Black-white disparity in disability among U.S. older adults: age, period, and cohort trends. / 09.2014 / PubMed / Full text
• Conserved mechanisms of tumorigenesis in the Drosophila adult midgut. / 2014 / PubMed / Full text
• CD4 T cell defects in the aged: causes, consequences and strategies to circumvent. / 06.2014 / PubMed / Full text

CA2

• Maintaining Aging Hippocampal Function with Safe and Feasible Shaking Exercise in SAMP10 Mice. / 2020 / PubMed / Full text
• One-year Follow-up Study of Hippocampal Subfield Atrophy in Alzheimer's Disease and Normal Aging. / 2019 / PubMed / Full text
• Maturation of PNN and ErbB4 Signaling in Area CA2 during Adolescence Underlies the Emergence of PV Interneuron Plasticity and Social Memory. / 29.10.2019 / PubMed / Full text
• Early disruption of parvalbumin expression and perineuronal nets in the hippocampus of the Tg2576 mouse model of Alzheimer's disease can be rescued by enriched environment. / 12.2018 / PubMed / Full text
• Protracted hippocampal development is associated with age-related improvements in memory during early childhood. / 01.07.2018 / PubMed / Full text
• Neurodevelopment and behavior in neonatal OXYS rats with genetically determined accelerated senescence. / 15.02.2018 / PubMed / Full text
• Effect of Chronic Administration of Resveratrol on Cognitive Performance during Aging Process in Rats. / 2017 / PubMed / Full text
• Time of day but not aging regulates 5-HT receptor binding sites in the hamster hippocampus. / 01.01.2018 / PubMed / Full text
• Cytoarchitectonically-driven MRI atlas of nonhuman primate hippocampus: Preservation of subfield volumes in aging. / 05.2019 / PubMed / Full text
• Hippocampal sclerosis, hippocampal neuron loss patterns and TDP-43 in the aged population. / 07.2018 / PubMed / Full text
• Aging Does Not Affect Axon Initial Segment Structure and Somatic Localization of Tau Protein in Hippocampal Neurons of Fischer 344 Rats. / 07-08.2017 / PubMed / Full text
• Dancing or Fitness Sport? The Effects of Two Training Programs on Hippocampal Plasticity and Balance Abilities in Healthy Seniors. / 2017 / PubMed / Full text
• Comparison of the influence of two models of mild stress on hippocampal brain-derived neurotrophin factor (BDNF) immunoreactivity in old age rats. / 2017 / PubMed / Full text
• Protective effects of high Tryptophan diet on aging-induced passive avoidance impairment and hippocampal apoptosis. / 01.2017 / PubMed / Full text
• Depressive symptoms modify age effects on hippocampal subfields in older adults. / 10.2017 / PubMed / Full text
• Roles of hippocampal subfields in verbal and visual episodic memory. / 15.01.2017 / PubMed / Full text
• Age-Dependent Specific Changes in Area CA2 of the Hippocampus and Social Memory Deficit in a Mouse Model of the 22q11.2 Deletion Syndrome. / 06.01.2016 / PubMed / Full text
• Changes in serotonin (5-HT) and brain-derived neurotrophic factor (BDFN) expression in frontal cortex and hippocampus of aged rat treated with high tryptophan diet. / 10.2015 / PubMed / Full text
• Hippocampal cytogenesis and spatial learning in senile rats exposed to chronic variable stress: effects of previous early life exposure to mild stress. / 2015 / PubMed / Full text
• Longitudinal reproducibility of automatically segmented hippocampal subfields: A multisite European 3T study on healthy elderly. / 09.2015 / PubMed / Full text
• Fluid percussion injury device for the precise control of injury parameters. / 15.06.2015 / PubMed / Full text
• Characterization of Periodic Acid-Schiff-Positive Granular Deposits in the Hippocampus of SJL/J Mice. / 07.2015 / PubMed / Full text
• Peripheral antioxidant markers are associated with total hippocampal and CA3/dentate gyrus volume in MDD and healthy controls-preliminary findings. / 30.12.2014 / PubMed / Full text
• Hippocampal subfield volumes at 7T in early Alzheimer's disease and normal aging. / 09.2014 / PubMed / Full text
• Moringa oleifera mitigates memory impairment and neurodegeneration in animal model of age-related dementia. / 2013 / PubMed / Full text

TLR2

• Changes in salivary microbial sensing proteins CD14 and TLR2 with aging. / 07.2020 / PubMed / Full text
• Culture Model for Non-human Primate Choroid Plexus. / 2019 / PubMed / Full text
• Changes in fetal membrane histology with cervical insufficiency and transabdominal cerclage. / 08.2019 / PubMed / Full text
• Aging leads to dysfunctional innate immune responses to TLR2 and TLR4 agonists. / 09.2019 / PubMed / Full text
• The Synergy of Aging and LPS Exposure in a Mouse Model of Parkinson's Disease. / 10.2018 / PubMed / Full text
• Aging modulates microglia phenotypes in neuroinflammation of MPTP-PD mice. / 01.10.2018 / PubMed / Full text
• Toll-like receptor 2 deficiency hyperactivates the FoxO1 transcription factor and induces aging-associated cardiac dysfunction in mice. / 24.08.2018 / PubMed / Full text
• Cryopreserved whole blood for the quantification of monocyte, T-cell and NK-cell subsets, and monocyte receptor expression by multi-color flow cytometry: A methodological study based on participants from the canadian longitudinal study on aging. / 05.2018 / PubMed / Full text
• TLR4 and TLR2 activation is differentially associated with age during Parkinson's disease. / 01.2018 / PubMed / Full text
• Role of pattern recognition receptors of the neurovascular unit in inflamm-aging. / 01.11.2017 / PubMed / Full text
• Ionizing radiation reduces ADAM10 expression in brain microvascular endothelial cells undergoing stress-induced senescence. / 04.2017 / PubMed / Full text
• Aging-related Atg5 defect impairs neutrophil extracellular traps formation. / 08.2017 / PubMed / Full text
• Chronoinflammaging in Alzheimer; A systematic review on the roles of toll like receptor 2. / 15.02.2017 / PubMed / Full text
• Aged B cells alter immune regulation of allografts in mice. / 11.2016 / PubMed / Full text
• Estrogen receptors alpha mediates postischemic inflammation in chronically estrogen-deprived mice. / 04.2016 / PubMed / Full text
• Effects of aerobic training on markers of autophagy in the elderly. / 04.2016 / PubMed / Full text
• Reduced levels of cytosolic DNA sensor AIM2 are associated with impaired cytokine responses in healthy elderly. / 06.2016 / PubMed / Full text
• Immune ageing and susceptibility to Streptococcus pneumoniae. / 06.2016 / PubMed / Full text
• Monocyte Phenotype and Polyfunctionality Are Associated With Elevated Soluble Inflammatory Markers, Cytomegalovirus Infection, and Functional and Cognitive Decline in Elderly Adults. / 05.2016 / PubMed / Full text
• Cathelicidin related antimicrobial peptide, laminin, Toll-like receptors and chemokines levels in experimental hypersensitivity pneumonitis in mice. / 06.2015 / PubMed / Full text
• Prophylactic lithium alleviates splenectomy-induced cognitive dysfunction possibly by inhibiting hippocampal TLR4 activation in aged rats. / 05.2015 / PubMed / Full text
• Altered neutrophil functions in elderly patients during a 6-month follow-up period after a hip fracture. / 05.2015 / PubMed / Full text
• Aging does not affect the ability of human monocyte-derived dendritic cells to phagocytose Candida albicans. / 12.2015 / PubMed / Full text
• Cardiac autonomic dysfunction: particulate air pollution effects are modulated by epigenetic immunoregulation of Toll-like receptor 2 and dietary flavonoid intake. / 27.01.2015 / PubMed / Full text
• Bacteria and Toll-like receptor and cytokine mRNA expression profiles associated with canine arthritis. / 15.08.2014 / PubMed / Full text

AFM

• Photocatalytic aging process of Nano-TiO coated polypropylene microplastics: Combining atomic force microscopy and infrared spectroscopy (AFM-IR) for nanoscale chemical characterization. / 15.02.2021 / PubMed / Full text
• Nanoscale infrared, thermal and mechanical properties of aged microplastics revealed by an atomic force microscopy coupled with infrared spectroscopy (AFM-IR) technique. / 20.11.2020 / PubMed / Full text
• Detecting zeta potential of polydimethylsiloxane (PDMS) in electrolyte solutions with atomic force microscope. / 15.10.2020 / PubMed / Full text
• Recent Applications of Advanced Atomic Force Microscopy in Polymer Science: A Review. / 17.05.2020 / PubMed / Full text
• Active fractions of mannoproteins derived from yeast cell wall stimulate innate and acquired immunity of adult and elderly dogs. / 03.2020 / PubMed / Full text
• The Effect of Waste Engine Oil and Waste Polyethylene on UV Aging Resistance of Asphalt. / 06.03.2020 / PubMed / Full text
• Mechanical properties measured by atomic force microscopy define health biomarkers in ageing C. elegans. / 25.02.2020 / PubMed / Full text
• Nanomechanical insights: Amyloid beta oligomer-induced senescent brain endothelial cells. / 01.12.2019 / PubMed / Full text
• Application of atomic force microscopy in the analysis of time since deposition (TSD) of red blood cells in bloodstains: A forensic analysis. / 08.2019 / PubMed / Full text
• Iceland spar calcite: Humidity and time effects on surface properties and their reversibility. / 01.04.2019 / PubMed / Full text
• Zebrafish as a model to study bone maturation: Nanoscale structural and mechanical characterization of age-related changes in the zebrafish vertebral column. / 08.2018 / PubMed / Full text
• Multiscale Poroviscoelastic Compressive Properties of Mouse Supraspinatus Tendons Are Altered in Young and Aged Mice. / 01.05.2018 / PubMed / Full text
• Proteomic Alterations Associated with Biomechanical Dysfunction are Early Processes in the Emilin1 Deficient Mouse Model of Aortic Valve Disease. / 11.2017 / PubMed / Full text
• Effect of intra-oral aging on t→m phase transformation, microstructure, and mechanical properties of Y-TZP dental ceramics. / 08.2017 / PubMed / Full text
• The Effect of Brushing and Aging on the Staining and Smoothness of Resin Composites. / 04.2017 / PubMed / Full text
• Frequency-modulated atomic force microscopy localises viscoelastic remodelling in the ageing sheep aorta. / 12.2016 / PubMed / Full text
• Changes in surface characteristics of two different resin composites after 1 year water storage: An SEM and AFM study. / 11.2016 / PubMed / Full text
• Wide bandwidth nanomechanical assessment of murine cartilage reveals protection of aggrecan knock-in mice from joint-overuse. / 14.06.2016 / PubMed / Full text
• Effect of at-home bleaching with different thickeners and aging on physical properties of a nanocomposite. / 01-03.2016 / PubMed / Full text
• Interaction of intraocular lenses with fibronectin and human lens epithelial cells: Effect of chemical composition and aging. / 12.2015 / PubMed / Full text
• β-Hydroxy-β-methylbutyrate (HMB) supplementation and resistance exercise significantly reduce abdominal adiposity in healthy elderly men. / 04.2015 / PubMed / Full text
• Atomic force microscopy reveals age-dependent changes in nanomechanical properties of the extracellular matrix of native human menisci: implications for joint degeneration and osteoarthritis. / 11.2014 / PubMed / Full text
• In situ atomic force microscopy analysis of morphology and particle size changes in lithium iron phosphate cathode during discharge. / 01.06.2014 / PubMed / Full text
• Load cycling enhances bioactivity at the resin-dentin interface. / 07.2014 / PubMed / Full text

GSC

• [i]mastermind[/i] regulates niche ageing independently of the [i]Notch[/i] pathway in the [i]Drosophila[/i] ovary. / 29.11.2019 / PubMed / Full text
• Germline stem cell homeostasis. / 2019 / PubMed / Full text
• Endocrine regulation of female germline stem cells in the fruit fly Drosophila melanogaster. / 02.2019 / PubMed / Full text
• Generation of Inducible Gene-Switched GAL4 Expressed in the [i]Drosophila[/i] Female Germline Stem Cell Niche. / 05.06.2019 / PubMed / Full text
• YAP/Yorkie in the germline modulates the age-related decline of germline stem cells and niche cells. / 2019 / PubMed / Full text
• Diminished Jak/STAT Signaling Causes Early-Onset Aging Defects in Stem Cell Cytokinesis. / 21.01.2019 / PubMed / Full text
• JNK signaling triggers spermatogonial dedifferentiation during chronic stress to maintain the germline stem cell pool in the [i]Drosophila[/i] testis. / 09.07.2018 / PubMed / Full text
• Age-related differences in BOLD modulation to cognitive control costs in a multitasking paradigm: Global switch, local switch, and compatibility-switch costs. / 15.05.2018 / PubMed / Full text
• Modelling glioblastoma tumour-host cell interactions using adult brain organotypic slice co-culture. / 22.02.2018 / PubMed / Full text
• Loss of [i]foxo[/i] rescues stem cell aging in [i]Drosophila[/i] germ line. / 19.09.2017 / PubMed / Full text
• DAF-18/PTEN signals through AAK-1/AMPK to inhibit MPK-1/MAPK in feedback control of germline stem cell proliferation. / 04.2017 / PubMed / Full text
• Antithrombotic agents intake prior to injury does not affect outcome after a traumatic brain injury in hospitalized elderly patients. / 04.2017 / PubMed / Full text
• Suberoylanilide hydroxamic acid represses glioma stem-like cells. / 18.11.2016 / PubMed / Full text
• Flavonoids and darkness lower PCD in senescing Vitis vinifera suspension cell cultures. / 26.10.2016 / PubMed / Full text
• DNA damage-induced Lok/CHK2 activation compromises germline stem cell self-renewal and lineage differentiation. / 01.12.2016 / PubMed / Full text
• The Wnt pathway limits BMP signaling outside of the germline stem cell niche in Drosophila ovaries. / 01.09.2016 / PubMed / Full text
• Nuclear hormone receptors as mediators of metabolic adaptability following reproductive perturbations. / 01-03.2016 / PubMed / Full text
• Senescence from glioma stem cell differentiation promotes tumor growth. / 05.02.2016 / PubMed / Full text
• Lipid-mediated regulation of SKN-1/Nrf in response to germ cell absence. / 24.08.2015 / PubMed / Full text
• Microglial voltage-gated sodium channels modulate cellular response in Alzheimer's disease--a new perspective on an old problem. / 2015 / PubMed
• Y-27632, a ROCK inhibitor, delays senescence of putative murine salivary gland stem cells in culture. / 06.2015 / PubMed / Full text
• Notch signaling mediates the age-associated decrease in adhesion of germline stem cells to the niche. / 12.2014 / PubMed / Full text
• Aging and insulin signaling differentially control normal and tumorous germline stem cells. / 02.2015 / PubMed / Full text
• [The opportunity to use combined stem cells transplantation for haemopoesis activation in the old and mature laboratory animals under the conditions of ionizing radiation]. / 2014 / PubMed

HGF

• Age-related changes in the immunomodulatory effects of human dental pulp derived mesenchymal stem cells on the CD4 T cell subsets. / 19.11.2020 / PubMed / Full text
• Hepatocyte growth factor (HGF) and stem cell factor (SCF) maintained the stemness of human bone marrow mesenchymal stem cells (hBMSCs) during long-term expansion by preserving mitochondrial function via the PI3K/AKT, ERK1/2, and STAT3 signaling pathways. / 31.07.2020 / PubMed / Full text
• Phenytoin sodium-ameliorated gingival fibroblast aging is associated with autophagy. / 10.2020 / PubMed / Full text
• Impaired integrin α /β -mediated hepatocyte growth factor release by stellate cells of the aged liver. / 04.2020 / PubMed / Full text
• Evaluation of the biological behaviour of various dental implant abutment materials on attachment and viability of human gingival fibroblasts. / 07.2019 / PubMed / Full text
• Characterization of aged rat vocal fold fibroblasts. / 03.2019 / PubMed / Full text
• Circulating Vascular Growth Factors and Magnetic Resonance Imaging Markers of Small Vessel Disease and Atrophy in Middle-Aged Adults. / 09.2018 / PubMed / Full text
• Assessment of Human Skin Gene Expression by Different Blends of Plant Extracts with Implications to Periorbital Skin Aging. / 26.10.2018 / PubMed / Full text
• Hepatocyte growth factor is a potential biomarker for osteoproliferation and osteoporosis in ankylosing spondylitis. / 02.2019 / PubMed / Full text
• Human amniotic mesenchymal stem cells improve ovarian function in natural aging through secreting hepatocyte growth factor and epidermal growth factor. / 09.03.2018 / PubMed / Full text
• HGF and BFGF Secretion by Human Adipose-Derived Stem Cells Improves Ovarian Function During Natural Aging via Activation of the SIRT1/FOXO1 Signaling Pathway. / 2018 / PubMed / Full text
• Cell-size-dependent upregulation of HGF expression in dermal fibroblasts: Impact on human skin connective tissue aging. / 12.2017 / PubMed / Full text
• Oxidative stress contributes to hepatocyte growth factor-dependent pro-senescence activity of ovarian cancer cells. / 09.2017 / PubMed / Full text
• Estrogen modulates mesenchyme-epidermis interactions in the adult nipple. / 15.04.2017 / PubMed / Full text
• Enhanced Functional Recovery from Spinal Cord Injury in Aged Mice after Stem Cell Transplantation through HGF Induction. / 14.03.2017 / PubMed / Full text
• Necroptosis Induced by Ad-HGF Activates Endogenous C-Kit Cardiac Stem Cells and Promotes Cardiomyocyte Proliferation and Angiogenesis in the Infarcted Aged Heart. / 2016 / PubMed / Full text
• Ovarian cancer-derived ascitic fluids induce a senescence-dependent pro-cancerogenic phenotype in normal peritoneal mesothelial cells. / 10.2016 / PubMed / Full text
• Influence of aging on the quantity and quality of human cardiac stem cells. / 07.03.2016 / PubMed / Full text
• Senescent peritoneal mesothelium induces a pro-angiogenic phenotype in ovarian cancer cells in vitro and in a mouse xenograft model in vivo. / 01.2016 / PubMed / Full text
• Macrophage migration inhibitory factor confers resistance to senescence through CD74-dependent AMPK-FOXO3a signaling in mesenchymal stem cells. / 22.04.2015 / PubMed / Full text
• Prevention of hair graying by factors that promote the growth and differentiation of melanocytes. / 08.2014 / PubMed / Full text
• Low-power laser irradiation fails to improve liver regeneration in elderly rats at 48 h after 70 % resection. / 09.2015 / PubMed / Full text
• Effect of AST on age-associated changes of vocal folds in a rat model. / 10.2014 / PubMed / Full text
• The role of growth factors in maintenance of stemness in bone marrow-derived mesenchymal stem cells. / 28.02.2014 / PubMed / Full text

SOX2

• Multiple nanosecond pulsed electric fields stimulation with conductive poly(l-lactic acid)/carbon nanotubes films maintains the multipotency of mesenchymal stem cells during prolonged in vitro culture. / 08.2020 / PubMed / Full text
• Subpopulations of miniature pig mesenchymal stromal cells with different differentiation potentials differ in the expression of octamer-binding transcription factor 4 and sex determining region Y-box 2. / 03.2020 / PubMed / Full text
• Increased Type I and Decreased Type II Hair Cells after Deletion of Sox2 in the Developing Mouse Utricle. / 01.12.2019 / PubMed / Full text
• 'Stemness' and 'senescence' related escape pathways are dose dependent in lung cancer cells surviving post irradiation. / 01.09.2019 / PubMed / Full text
• Cellular senescence in progenitor cells contributes to diminished remyelination potential in progressive multiple sclerosis. / 30.04.2019 / PubMed / Full text
• The senescent status of endothelial cells affects proliferation, inflammatory profile and SOX2 expression in bone marrow-derived mesenchymal stem cells. / 06.2019 / PubMed / Full text
• Isolation, Characterization, and Differentiation of Cardiac Stem Cells from the Adult Mouse Heart. / 07.01.2019 / PubMed / Full text
• A stably self-renewing adult blood-derived induced neural stem cell exhibiting patternability and epigenetic rejuvenation. / 02.10.2018 / PubMed / Full text
• MicroRNA-338-5p plays a tumor suppressor role in glioma through inhibition of the MAPK-signaling pathway by binding to FOXD1. / 12.2018 / PubMed / Full text
• Centenarians Overexpress Pluripotency-Related Genes. / 16.08.2019 / PubMed / Full text
• MYC Releases Early Reprogrammed Human Cells from Proliferation Pause via Retinoblastoma Protein Inhibition. / 10.04.2018 / PubMed / Full text
• SOX2 expression diminishes with ageing in several tissues in mice and humans. / 01.2019 / PubMed / Full text
• Coupling shRNA screens with single-cell RNA-seq identifies a dual role for mTOR in reprogramming-induced senescence. / 15.10.2017 / PubMed / Full text
• ZSCAN10 expression corrects the genomic instability of iPSCs from aged donors. / 09.2017 / PubMed / Full text
• Induced Pluripotent Stem Cell-Derived Dopaminergic Neurons from Adult Common Marmoset Fibroblasts. / 01.09.2017 / PubMed / Full text
• Role of p16 and BMI-1 in oxidative stress-induced premature senescence in human dental pulp stem cells. / 08.2017 / PubMed / Full text
• Autophagic homeostasis is required for the pluripotency of cancer stem cells. / 02.2017 / PubMed / Full text
• The p53 Pathway Controls SOX2-Mediated Reprogramming in the Adult Mouse Spinal Cord. / 11.10.2016 / PubMed / Full text
• Sox2-Deficient Müller Glia Disrupt the Structural and Functional Maturation of the Mammalian Retina. / 03.2016 / PubMed / Full text
• mTOR inhibition decreases SOX2-SOX9 mediated glioma stem cell activity and temozolomide resistance. / 2016 / PubMed / Full text
• Disentangling the aneuploidy and senescence paradoxes: a study of triploid breast cancers non-responsive to neoadjuvant therapy. / 04.2016 / PubMed / Full text
• Role of stress-activated OCT4A in the cell fate decisions of embryonal carcinoma cells treated with etoposide. / 2015 / PubMed / Full text
• Critical role of the miR-200 family in regulating differentiation and proliferation of neurons. / 06.2015 / PubMed / Full text
• Localization of juxtacrine factor ephrin-B2 in pituitary stem/progenitor cell niches throughout life. / 03.2015 / PubMed / Full text

BRAF

• Conditional reprograming culture conditions facilitate growth of lower grade glioma models. / 01.12.2020 / PubMed / Full text
• Active notch protects MAPK activated melanoma cell lines from MEK inhibitor cobimetinib. / 14.11.2020 / PubMed / Full text
• Mitochondrial metabolic reprograming via BRAF inhibition ameliorates senescence. / 15.10.2019 / PubMed / Full text
• Deciphering the genotype and phenotype of hairy cell leukemia: clues for diagnosis and treatment. / 08.2019 / PubMed / Full text
• A clinical trial of somatic and germline analyses for healthy longevity in a postoperative cancer patient. / 09.2019 / PubMed / Full text
• Aging-like Spontaneous Epigenetic Silencing Facilitates Wnt Activation, Stemness, and Braf -Induced Tumorigenesis. / 11.02.2019 / PubMed / Full text
• Acquired resistance to BRAFi reverses senescence-like phenotype in mutant BRAF melanoma. / 07.08.2018 / PubMed / Full text
• Cancer modeling by Transgene Electroporation in Adult Zebrafish (TEAZ). / 27.09.2018 / PubMed / Full text
• Menopause and adipose tissue: miR-19a-3p is sensitive to hormonal replacement. / 05.01.2018 / PubMed / Full text
• Impact of Age on Outcomes with Immunotherapy for Patients with Melanoma. / 08.2017 / PubMed / Full text
• Establishment and application of a novel patient-derived KIAA1549:BRAF-driven pediatric pilocytic astrocytoma model for preclinical drug testing. / 14.02.2017 / PubMed / Full text
• Detection of Reactive Oxygen Species in Cells Undergoing Oncogene-Induced Senescence. / 2017 / PubMed / Full text
• GBM-associated mutations and altered protein expression are more common in young patients. / 25.10.2016 / PubMed / Full text
• What makes oncogenes mutually exclusive? / 03.07.2017 / PubMed / Full text
• Suppression of Type I Interferon Signaling Overcomes Oncogene-Induced Senescence and Mediates Melanoma Development and Progression. / 05.04.2016 / PubMed / Full text
• Combination with γ-secretase inhibitor prolongs treatment efficacy of BRAF inhibitor in BRAF-mutated melanoma cells. / 28.06.2016 / PubMed / Full text
• Parthenolide induces MITF-M downregulation and senescence in patient-derived MITF-M(high) melanoma cell populations. / 23.02.2016 / PubMed / Full text
• Encorafenib (LGX818), a potent BRAF inhibitor, induces senescence accompanied by autophagy in BRAFV600E melanoma cells. / 28.01.2016 / PubMed / Full text
• Novel Therapies for Metastatic Melanoma: An Update on Their Use in Older Patients. / 10.2015 / PubMed / Full text
• Expression of tumor-related Rac1b antagonizes B-Raf-induced senescence in colorectal cells. / 28.12.2015 / PubMed / Full text
• Trametinib radiosensitises RAS- and BRAF-mutated melanoma by perturbing cell cycle and inducing senescence. / 11.2015 / PubMed / Full text
• Near-genomewide RNAi screening for regulators of BRAF(V600E) -induced senescence identifies RASEF, a gene epigenetically silenced in melanoma. / 07.2014 / PubMed / Full text
• Oncogene-induced senescence distinguishes indolent from aggressive forms of pulmonary and non-pulmonary Langerhans cell histiocytosis. / 11.2014 / PubMed / Full text

CD36

• Liver osteopontin is required to prevent the progression of age-related nonalcoholic fatty liver disease. / 08.2020 / PubMed / Full text
• Reduction of senescence-associated beta-galactosidase activity by vitamin E in human fibroblasts depends on subjects' age and cell passage number. / 07.2020 / PubMed / Full text
• Niacin-mediated rejuvenation of macrophage/microglia enhances remyelination of the aging central nervous system. / 05.2020 / PubMed / Full text
• Human bone marrow adipocytes display distinct immune regulatory properties. / 08.2019 / PubMed / Full text
• Expression of digestive enzyme and intestinal transporter genes during chronic heat stress in the thermally manipulated broiler chicken. / 01.09.2019 / PubMed / Full text
• Pathophysiological significance of cylindromatosis in the vascular endothelium and macrophages for the initiation of age-related atherogenesis. / 22.01.2019 / PubMed / Full text
• The adhesion and migration of microglia to β-amyloid (Aβ) is decreased with aging and inhibited by Nogo/NgR pathway. / 20.07.2018 / PubMed / Full text
• Cell-surface phenotyping identifies CD36 and CD97 as novel markers of fibroblast quiescence in lung fibrosis. / 01.11.2018 / PubMed / Full text
• An evolutionary transcriptomics approach links CD36 to membrane remodeling in replicative senescence. / 06.08.2018 / PubMed / Full text
• Comparative analysis of endothelial cell and sub-endothelial cell elastic moduli in young and aged mice: Role of CD36. / 25.07.2018 / PubMed / Full text
• CD36 initiates the secretory phenotype during the establishment of cellular senescence. / 06.2018 / PubMed / Full text
• Senescence Alters PPARγ (Peroxisome Proliferator-Activated Receptor Gamma)-Dependent Fatty Acid Handling in Human Adipose Tissue Microvascular Endothelial Cells and Favors Inflammation. / 05.2018 / PubMed / Full text
• Developmental differences between neonatal and adult human erythropoiesis. / 08.2018 / PubMed / Full text
• Effects of high-fat diet and age on the blood lipidome and circulating endocannabinoids of female C57BL/6 mice. / 01.2018 / PubMed / Full text
• Increased White Matter Inflammation in Aging- and Alzheimer's Disease Brain. / 2017 / PubMed / Full text
• Thyroid hormone-stimulated increases in PGC-1α and UCP2 promote life history-specific endocrine changes and maintain a lipid-based metabolism. / 01.02.2017 / PubMed / Full text
• The Drosophila CD36 Homologue croquemort Is Required to Maintain Immune and Gut Homeostasis during Development and Aging. / 10.2016 / PubMed / Full text
• Distinct inflammatory phenotypes of microglia and monocyte-derived macrophages in Alzheimer's disease models: effects of aging and amyloid pathology. / 02.2017 / PubMed / Full text
• Modulation of Macrophage Polarization and HMGB1-TLR2/TLR4 Cascade Plays a Crucial Role for Cardiac Remodeling in Senescence-Accelerated Prone Mice. / 2016 / PubMed / Full text
• Impact of age and sex on the development of atherosclerosis and expression of the related genes in apoE deficient mice. / 15.01.2016 / PubMed / Full text
• Effect of testosterone on markers of mitochondrial oxidative phosphorylation and lipid metabolism in muscle of aging men with subnormal bioavailable testosterone. / 07.2014 / PubMed / Full text
• Increased hepatic CD36 expression with age is associated with enhanced susceptibility to nonalcoholic fatty liver disease. / 04.2014 / PubMed / Full text
• Long-term vitamin E supplementation reduces atherosclerosis and mortality in Ldlr-/- mice, but not when fed Western style diet. / 03.2014 / PubMed / Full text

CIT

• Effect of sex on aging-related decline of dopamine transporter in healthy subjects. / 14.10.2020 / PubMed / Full text
• The Relationship Between the Striatal Dopaminergic Neuronal and Cognitive Function With Aging. / 2020 / PubMed / Full text
• Initial Dietary Protein Intake Influence Muscle Function Adaptations in Older Men and Women Following High-Intensity Interval Training Combined with Citrulline. / 22.07.2019 / PubMed / Full text
• I-FP-CIT striatal binding ratios do not decrease significantly with age in older adults. / 06.2019 / PubMed / Full text
• Effect of High-Intensity Interval Training Combined with L-Citrulline Supplementation on Functional Capacities and Muscle Function in Dynapenic-Obese Older Adults. / 17.12.2018 / PubMed / Full text
• The Six-Item Cognitive Impairment Test Is Associated with Adverse Outcomes in Acutely Hospitalized Older Patients: A Prospective Cohort Study. / 05-08.2018 / PubMed / Full text
• Dopaminergic imaging separates normal pressure hydrocephalus from its mimics. / 10.2018 / PubMed / Full text
• Lower Cognitive Function in Older Patients with Lower Muscle Strength and Muscle Mass. / 2018 / PubMed / Full text
• Citrulline counteracts overweight- and aging-related effects on adiponectin and leptin gene expression in rat white adipose tissue. / 2015 / PubMed / Full text
• Overcoming Barriers of Age to Enhance Efficacy of Cancer Immunotherapy: The Clout of the Extracellular Matrix. / 2018 / PubMed / Full text
• Validation of the 6-Item Cognitive Impairment Test and the 4AT test for combined delirium and dementia screening in older Emergency Department attendees. / 01.01.2018 / PubMed / Full text
• Octogenarian liver grafts: Is their use for transplant currently justified? / 07.05.2017 / PubMed / Full text
• Citrulline stimulates locomotor activity in aged rats: Implication of the dopaminergic pathway. / 06.2017 / PubMed / Full text
• Age-related effects and gender differences in Japanese healthy controls for [ I] FP-CIT SPECT. / 06.2017 / PubMed / Full text
• The changes of individual carotid artery wall layer by aging and carotid intima-media thickness value for high risk. / 12.2016 / PubMed / Full text
• Melodic Contour Identification Reflects the Cognitive Threshold of Aging. / 2016 / PubMed / Full text
• Effects of Donor Age and Cold Ischemia on Liver Transplantation Outcomes According to the Severity of Recipient Status. / 02.2016 / PubMed / Full text
• Aging and chronic administration of serotonin-selective reuptake inhibitor citalopram upregulate Sirt4 gene expression in the preoptic area of male mice. / 2015 / PubMed / Full text
• Effects of aging and gender on striatal and extrastriatal [123I]FP-CIT binding in Parkinson's disease. / 04.2015 / PubMed / Full text
• Dopamine transporter imaging in the aged rat: a [¹²³I]FP-CIT SPECT study. / 04.2015 / PubMed / Full text
• Uneven age effects of [(18)F]FP-CIT binding in the striatum of Parkinson's disease. / 11.2014 / PubMed / Full text
• Citrulline induces fatty acid release selectively in visceral adipose tissue from old rats. / 09.2014 / PubMed / Full text
• Prognostic factors for kidney allograft survival in the Eurotransplant Senior Program. / 01.05.2014 / PubMed / Full text

DCX

• GSK-3β activation accelerates early-stage consumption of Hippocampal Neurogenesis in senescent mice. / 2020 / PubMed / Full text
• Doublecortin and IGF-1R protein levels are reduced in spite of unchanged DNA methylation in the hippocampus of aged rats. / 04.2020 / PubMed / Full text
• Human Hippocampal Neurogenesis Persists in Aged Adults and Alzheimer's Disease Patients. / 06.06.2019 / PubMed / Full text
• Age-related changes in Ki-67 and DCX expression in the BALB/ c mouse (Mus Musculus) brain. / 02.2019 / PubMed / Full text
• Inflammation-induced Gro1 triggers senescence in neuronal progenitors: effects of estradiol. / 11.09.2018 / PubMed / Full text
• Neuroprotective Effects of the Multitarget Agent AVCRI104P3 in Brain of Middle-Aged Mice. / 04.09.2018 / PubMed / Full text
• Differential effects of adolescent and adult-initiated voluntary exercise on context and cued fear conditioning. / 02.2019 / PubMed / Full text
• Hippocampal neurogenesis in the C57BL/6J mice at early adulthood following prenatal alcohol exposure. / 04.2018 / PubMed / Full text
• Puerarin and Amlodipine Improvement of D-Galactose-Induced Impairments of Behaviour and Neurogenesis in Mouse Dentate Gyrus: Correlation with Glucocorticoid Receptor Expression. / 11.2017 / PubMed / Full text
• Evidence for reduced neurogenesis in the aging human hippocampus despite stable stem cell markers. / 10.2017 / PubMed / Full text
• Early-life decline in neurogenesis markers and age-related changes of TrkB splice variant expression in the human subependymal zone. / 07.2017 / PubMed / Full text
• Dehydroepiandrosterone increases the number and dendrite maturation of doublecortin cells in the dentate gyrus of middle age male Wistar rats exposed to chronic mild stress. / 15.03.2017 / PubMed / Full text
• Neurogenesis upregulation on the healthy hemisphere after stroke enhances compensation for age-dependent decrease of basal neurogenesis. / 03.2017 / PubMed / Full text
• Postnatal maturation of mouse medullo-spinal cerebrospinal fluid-contacting neurons. / 20.02.2017 / PubMed / Full text
• Topiramate Improves Neuroblast Differentiation of Hippocampal Dentate Gyrus in the D-Galactose-Induced Aging Mice via Its Antioxidant Effects. / 07.2017 / PubMed / Full text
• Adenosine A1 receptor antagonist mitigates deleterious effects of sleep deprivation on adult neurogenesis and spatial reference memory in rats. / 19.11.2016 / PubMed / Full text
• Sex-Specific Effects of Prenatal Stress on Memory and Markers of Neuronal Activity in Juvenile Rats. / 2016 / PubMed / Full text
• MeHg Suppressed Neuronal Potency of Hippocampal NSCs Contributing to the Puberal Spatial Memory Deficits. / 08.2016 / PubMed / Full text
• Hypercrosslinked Additives for Ageless Gas-Separation Membranes. / 05.02.2016 / PubMed / Full text
• Fibroblast Growth Factor 14 Modulates the Neurogenesis of Granule Neurons in the Adult Dentate Gyrus. / 12.2016 / PubMed / Full text
• Effects of Ginko biloba leaf extract on the neurogenesis of the hippocampal dentate gyrus in the elderly mice. / 06.2016 / PubMed / Full text
• Persistent loss of hippocampal neurogenesis and increased cell death following adolescent, but not adult, chronic ethanol exposure. / 2014 / PubMed / Full text
• Lactobacillus pentosus var. plantarum C29 ameliorates memory impairment and inflammaging in a D-galactose-induced accelerated aging mouse model. / 06.2014 / PubMed / Full text

F3

• A Comprehensive Analysis of Age and Gender Effects in European Portuguese Oral Vowels. / 05.12.2020 / PubMed / Full text
• Prenatal exposure to an environmentally relevant phthalate mixture accelerates biomarkers of reproductive aging in a multiple and transgenerational manner in female mice. / 28.10.2020 / PubMed / Full text
• Combining Frontal Transcranial Direct Current Stimulation With Walking Rehabilitation to Enhance Mobility and Executive Function: A Pilot Clinical Trial. / 18.08.2020 / PubMed / Full text
• Multigenerational exposure to TiO nanoparticles in soil stimulates stress resistance and longevity of survived C. elegans via activating insulin/IGF-like signaling. / 08.2020 / PubMed / Full text
• Co-expression network analysis identified hub genes critical to triglyceride and free fatty acid metabolism as key regulators of age-related vascular dysfunction in mice. / 12.09.2019 / PubMed / Full text
• Transgenerational Effects of Extended Dauer Diapause on Starvation Survival and Gene Expression Plasticity in [i]Caenorhabditis elegans[/i]. / 09.2018 / PubMed / Full text
• Influence of Supplemental Protein on the Life Expectancy and Reproduction of the Chinese Citrus Fruit Fly, Bactrocera minax (Enderlein) (Tetradacus minax) (Diptera: Tephritidae). / 01.03.2018 / PubMed / Full text
• Early-life exposure to three size-fractionated ultrafine and fine atmospheric particulates in Beijing exacerbates asthma development in mature mice. / 14.03.2018 / PubMed / Full text
• Multigenerational effects of 4-methylbenzylidene camphor (4-MBC) on the survival, development and reproduction of the marine copepod Tigriopus japonicus. / 01.2018 / PubMed / Full text
• Effects of Aging on Vocal Fundamental Frequency and Vowel Formants in Men and Women. / 09.2018 / PubMed / Full text
• Shedding light on gray(ing) areas: Connectivity and task switching dynamics in aging. / 03.2018 / PubMed / Full text
• Chronic exposure of zinc oxide nanoparticles causes deviant phenotype in Drosophila melanogaster. / 05.04.2017 / PubMed / Full text
• Treatment of Chronic Hepatitis C in the Aged - Does It Impact Life Expectancy? A Decision Analysis. / 2016 / PubMed / Full text
• Transgenerational programming of longevity and reproduction by post-eclosion dietary manipulation in Drosophila. / 05.2016 / PubMed / Full text
• Spectrographic Acoustic Vocal Characteristics of Elderly Women Engaged in Aerobics. / 09.2016 / PubMed / Full text
• Fat and carbohydrate intake over three generations modify growth, metabolism and cardiovascular phenotype in female mice in an age-related manner. / 2015 / PubMed / Full text
• Effect of semolina-jaggery diet on survival and development of Drosophila melanogaster. / 2015 / PubMed / Full text
• Differential regulation of apoptosis in slow and fast twitch muscles of aged female F344BN rats. / 2015 / PubMed / Full text
• Dexmedetomidine and regulation of splenic sympathetic nerve discharge in aged F344 rats. / 07.2015 / PubMed / Full text
• Comprehensive analysis of the ubiquitinome during oncogene-induced senescence in human fibroblasts. / 2015 / PubMed / Full text
• Docosahexaenoic acid in Arctic charr (Salvelinus alpinus): the importance of dietary supply and physiological response during the entire growth period. / 03.2015 / PubMed / Full text
• Starvation-induced transgenerational inheritance of small RNAs in C. elegans. / 17.07.2014 / PubMed / Full text
• Air pollution and gene-specific methylation in the Normative Aging Study: association, effect modification, and mediation analysis. / 03.2014 / PubMed / Full text

GHR

• Tissue-Specific GHR Knockout Mice: An Updated Review. / 2020 / PubMed / Full text
• The mir-465 family is upregulated with age and attenuates growth hormone signaling in mouse liver. / 04.2019 / PubMed / Full text
• Growth hormone during in vitro fertilization in older women modulates the density of receptors in granulosa cells, with improved pregnancy outcomes. / 12.2018 / PubMed / Full text
• Effects of rapamycin on growth hormone receptor knockout mice. / 13.02.2018 / PubMed / Full text
• Disruption of the GH receptor gene in adult mice and in insulin sensitive tissues. / 02.2018 / PubMed / Full text
• The GH receptor exon 3 deletion is a marker of male-specific exceptional longevity associated with increased GH sensitivity and taller stature. / 06.2017 / PubMed / Full text
• Differential effects of early-life nutrient restriction in long-lived GHR-KO and normal mice. / 06.2017 / PubMed / Full text
• Brain Structure and Function Associated with Younger Adults in Growth Hormone Receptor-Deficient Humans. / 15.02.2017 / PubMed / Full text
• Enhanced Cognition and Hypoglutamatergic Signaling in a Growth Hormone Receptor Knockout Mouse Model of Successful Aging. / 01.03.2017 / PubMed / Full text
• Growth hormone receptor expression in human gluteal versus abdominal subcutaneous adipose tissue: Association with body shape. / 05.2016 / PubMed / Full text
• The somatotropic axis and aging: Benefits of endocrine defects. / 04.2016 / PubMed / Full text
• Growth factors, aging and age-related diseases. / 06.2016 / PubMed / Full text
• Correlation Analysis Between Expression Levels of Hepatic Growth Hormone Receptor, Janus Kinase 2, Insulin-Like Growth Factor-I Genes and Dwarfism Phenotype in Bama Minipig. / 02.2015 / PubMed / Full text
• Growth hormone modulates hypothalamic inflammation in long-lived pituitary dwarf mice. / 12.2015 / PubMed / Full text
• Removal of growth hormone receptor (GHR) in muscle of male mice replicates some of the health benefits seen in global GHR-/- mice. / 07.2015 / PubMed / Full text
• Gene expression of key regulators of mitochondrial biogenesis is sex dependent in mice with growth hormone receptor deletion in liver. / 03.2015 / PubMed / Full text
• Conservation of pro-longevity genes among mammals. / 03.2015 / PubMed / Full text
• Interaction of growth hormone receptor/binding protein gene disruption and caloric restriction for insulin sensitivity and attenuated aging. / 2014 / PubMed / Full text
• Inflammatory and Glutamatergic Homeostasis Are Involved in Successful Aging. / 03.2016 / PubMed / Full text
• Specific suppression of insulin sensitivity in growth hormone receptor gene-disrupted (GHR-KO) mice attenuates phenotypic features of slow aging. / 12.2014 / PubMed / Full text
• Molecular evolution of growth hormone and insulin-like growth factor 1 receptors in long-lived, small-bodied mammals. / 10.10.2014 / PubMed / Full text
• Low protein intake is associated with a major reduction in IGF-1, cancer, and overall mortality in the 65 and younger but not older population. / 04.03.2014 / PubMed / Full text
• Expression of apoptosis-related genes in liver-specific growth hormone receptor gene-disrupted mice is sex dependent. / 01.2015 / PubMed / Full text

VDR

• 25-Hydroxyvitamin D positively regulates periodontal inflammaging via SOCS3/STAT signaling in diabetic mice. / 04.2020 / PubMed / Full text
• 1,25-Dihydroxyvitamin D protects against age-related osteoporosis by a novel VDR-Ezh2-p16 signal axis. / 02.2020 / PubMed / Full text
• Active vitamin D impedes the progression of non-alcoholic fatty liver disease by inhibiting cell senescence in a rat model. / 09.2020 / PubMed / Full text
• Age-dependent expression of the vitamin D receptor and the protective effect of vitamin D receptor activation on H O -induced apoptosis in rat intervertebral disc cells. / 06.2019 / PubMed / Full text
• Vitamin D Receptor in Muscle Atrophy of Elderly Patients: A Key Element of Osteoporosis-Sarcopenia Connection. / 12.2018 / PubMed / Full text
• Reduced vitamin D receptor (VDR) expression and plasma vitamin D levels are associated with aging-related prostate lesions. / 05.2018 / PubMed / Full text
• VDR Activation Reduces Proteinuria and High-Glucose-Induced Injury of Kidneys and Podocytes by Regulating Wnt Signaling Pathway. / 2017 / PubMed / Full text
• Vitamin D and the brain: Genomic and non-genomic actions. / 15.09.2017 / PubMed / Full text
• Targeted next generation sequencing of the entire vitamin D receptor gene reveals polymorphisms correlated with vitamin D deficiency among older Filipino women with and without fragility fracture. / 03.2017 / PubMed / Full text
• Using Hyperpolarized Xe MRI to Quantify the Pulmonary Ventilation Distribution. / 12.2016 / PubMed / Full text
• Lead-Related Genetic Loci, Cumulative Lead Exposure and Incident Coronary Heart Disease: The Normative Aging Study. / 2016 / PubMed / Full text
• Relationship between cardiometabolic profile, vitamin D status and BsmI polymorphism of the VDR gene in non-institutionalized elderly subjects: Cardiometabolic profile, vitamin D status and BsmI polymorphism of the VDR gene in non-institutionalized elderly subjects. / 08.2016 / PubMed / Full text
• Impact of vitamin D receptor polymorphisms in centenarians. / 08.2016 / PubMed / Full text
• Aging and a long-term diabetes mellitus increase expression of 1 α-hydroxylase and vitamin D receptors in the rat liver. / 12.2015 / PubMed / Full text
• Nuclear hormone receptors: Roles of xenobiotic detoxification and sterol homeostasis in healthy aging. / 2015 / PubMed / Full text
• Vitamin D Receptor Ablation and Vitamin D Deficiency Result in Reduced Grip Strength, Altered Muscle Fibers, and Increased Myostatin in Mice. / 12.2015 / PubMed / Full text
• Extra-intestinal calcium handling contributes to normal serum calcium levels when intestinal calcium absorption is suboptimal. / 12.2015 / PubMed / Full text
• Vitamin D Receptor Genotype Modulates the Correlation between Vitamin D and Circulating Levels of let-7a/b and Vitamin D Intake in an Elderly Cohort. / 2014 / PubMed / Full text
• Vitamin D, muscle and bone: Integrating effects in development, aging and injury. / 15.07.2015 / PubMed / Full text
• Association between vitamin D concentration and levels of sex hormones in an elderly Polish population with different genotypes of VDR polymorphisms (rs10735810, rs1544410, rs7975232, rs731236). / 15.03.2015 / PubMed / Full text
• Effect modification by vitamin D receptor genetic polymorphisms in the association between cumulative lead exposure and pulse pressure: a longitudinal study. / 13.01.2015 / PubMed / Full text
• Vitamin D receptor and megalin gene polymorphisms are associated with central adiposity status and changes among US adults. / 2013 / PubMed / Full text
• Vitamin D signaling in myogenesis: potential for treatment of sarcopenia. / 2014 / PubMed / Full text

EZH2

• Linking gene expression and phenotypic changes in the developmental and evolutionary origins of osteosclerosis in the ribs of bowhead whales (Balaena mysticetus). / 09.2020 / PubMed / Full text
• EZH2 is involved in vulnerability to neuroinflammation and depression-like behaviors induced by chronic stress in different aged mice. / 01.07.2020 / PubMed / Full text
• A positive feedback loop between EZH2 and NOX4 regulates nucleus pulposus cell senescence in age-related intervertebral disc degeneration. / 2020 / PubMed / Full text
• Perinatal exposure to bisphenol A impacts in the mammary gland morphology of adult Mongolian gerbils. / 04.2020 / PubMed / Full text
• Long noncoding RNA MALAT1 potentiates growth and inhibits senescence by antagonizing ABI3BP in gallbladder cancer cells. / 07.06.2019 / PubMed / Full text
• Epigenetic Co-Deregulation of EZH2/TET1 is a Senescence-Countering, Actionable Vulnerability in Triple-Negative Breast Cancer. / 2019 / PubMed / Full text
• Improving Treatment for Myelodysplastic Syndromes Patients. / 25.10.2018 / PubMed / Full text
• Aging Suppresses Skin-Derived Circulating SDF1 to Promote Full-Thickness Tissue Regeneration. / 25.09.2018 / PubMed / Full text
• Epigallocatechin-3-gallate and BIX-01294 have different impact on epigenetics and senescence modulation in acute and chronic myeloid leukemia cells. / 05.11.2018 / PubMed / Full text
• Selective molecular biomarkers to predict biologic behavior in pituitary tumors. / 05.2017 / PubMed / Full text
• Regulation of Cellular Senescence by Polycomb Chromatin Modifiers through Distinct DNA Damage- and Histone Methylation-Dependent Pathways. / 27.03.2018 / PubMed / Full text
• Region specific knock-out reveals distinct roles of chromatin modifiers in adult neurogenic niches. / 2018 / PubMed / Full text
• Conserved effect of aging on DNA methylation and association with EZH2 polycomb protein in mice and humans. / 03.2017 / PubMed / Full text
• The Ubiquitin-like with PHD and Ring Finger Domains 1 (UHRF1)/DNA Methyltransferase 1 (DNMT1) Axis Is a Primary Regulator of Cell Senescence. / 03.03.2017 / PubMed / Full text
• Enhancer of Zeste Homolog 2 and Histone Deacetylase 9c Regulate Age-Dependent Mesenchymal Stem Cell Differentiation into Osteoblasts and Adipocytes. / 08.2016 / PubMed / Full text
• Insight into the molecular pathophysiology of myelodysplastic syndromes: targets for novel therapy. / 10.2016 / PubMed / Full text
• HBP1-mediated Regulation of p21 Protein through the Mdm2/p53 and TCF4/EZH2 Pathways and Its Impact on Cell Senescence and Tumorigenesis. / 10.06.2016 / PubMed / Full text
• New concept: cellular senescence in pathophysiology of cholangiocarcinoma. / 2016 / PubMed / Full text
• SIRT1 affects DNA methylation of polycomb group protein target genes, a hotspot of the epigenetic shift observed in ageing. / 24.06.2015 / PubMed / Full text
• Enhancer of zeste homolog 2 depletion induces cellular senescence via histone demethylation along the INK4/ARF locus. / 08.2015 / PubMed / Full text
• Polycomb repressive complex 2 epigenomic signature defines age-associated hypermethylation and gene expression changes. / 2015 / PubMed / Full text
• Luotonin-A based quinazolinones cause apoptosis and senescence via HDAC inhibition and activation of tumor suppressor proteins in HeLa cells. / 13.04.2015 / PubMed / Full text

MAPT

• Association of relative brain age with tobacco smoking, alcohol consumption, and genetic variants. / 30.01.2020 / PubMed / Full text
• A blood-based nutritional risk index explains cognitive enhancement and decline in the multidomain Alzheimer prevention trial. / 2019 / PubMed / Full text
• Longitudinal associations of physical activity levels with morphological and functional changes related with aging: The MAPT study. / 12.2019 / PubMed / Full text
• Ageing and amyloidosis underlie the molecular and pathological alterations of tau in a mouse model of familial Alzheimer's disease. / 31.10.2019 / PubMed / Full text
• Revisiting the intersection of amyloid, pathologically modified tau and iron in Alzheimer's disease from a ferroptosis perspective. / 01.2020 / PubMed / Full text
• Factors associated with changes of the frailty status after age 70: Findings in the MAPT study. / 06.2019 / PubMed / Full text
• Mitophagy and NAD inhibit Alzheimer disease. / 06.2019 / PubMed / Full text
• Cognitive changes of older adults with an equivocal amyloid load. / 04.2019 / PubMed / Full text
• Tauopathy: A common mechanism for neurodegeneration and brain aging. / 03.2019 / PubMed / Full text
• Cinnamaldehyde Improves Lifespan and Healthspan in [i]Drosophila melanogaster[/i] Models for Alzheimer's Disease. / 2018 / PubMed / Full text
• Sex and age interact to determine clinicopathologic differences in Alzheimer's disease. / 12.2018 / PubMed / Full text
• Effects of a 3-Year Multi-Domain Intervention with or without Omega-3 Supplementation on Cognitive Functions in Older Subjects with Increased CAIDE Dementia Scores. / 2018 / PubMed / Full text
• Whole-Exome Sequencing of an Exceptional Longevity Cohort. / 16.08.2019 / PubMed / Full text
• Interaction between a MAPT variant causing frontotemporal dementia and mutant APP affects axonal transport. / 08.2018 / PubMed / Full text
• Evaluating the Patterns of Aging-Related Tau Astrogliopathy Unravels Novel Insights Into Brain Aging and Neurodegenerative Diseases. / 01.04.2017 / PubMed / Full text
• CSF protein changes associated with hippocampal sclerosis risk gene variants highlight impact of GRN/PGRN. / 04.2017 / PubMed / Full text
• Koolen-de Vries Syndrome: Clinical Report of an Adult and Literature Review. / 2016 / PubMed / Full text
• Presymptomatic cognitive decline in familial frontotemporal dementia: A longitudinal study. / 26.07.2016 / PubMed / Full text
• Frontotemporal dementia: insights into the biological underpinnings of disease through gene co-expression network analysis. / 24.02.2016 / PubMed / Full text
• Cellular and molecular modifier pathways in tauopathies: the big picture from screening invertebrate models. / 04.2016 / PubMed / Full text
• Drosophila models of Alzheimer's disease: advances, limits, and perspectives. / 2015 / PubMed / Full text
• Association between MAPT haplotype and memory function in patients with Parkinson's disease and healthy aging individuals. / 03.2015 / PubMed / Full text

MBP

• Demyelination associated with chronic arsenic exposure in Wistar rats. / 15.04.2020 / PubMed / Full text
• Natural killer cells as participants in pathogenesis of rat experimental autoimmune encephalomyelitis (EAE): lessons from research on rats with distinct age and strain. / 2019 / PubMed / Full text
• Whey protein concentrate supplementation protects rat brain against aging-induced oxidative stress and neurodegeneration. / 05.2018 / PubMed / Full text
• Strain specificities in age-related changes in mechanisms promoting and controlling rat spinal cord damage in experimental autoimmune encephalomyelitis. / 01.2018 / PubMed / Full text
• Age-dependent differences in myelin basic protein expression in the hippocampus of young, adult and aged gerbils. / 09.2017 / PubMed / Full text
• Schwann Cell Phenotype Changes in Aging Human Dental Pulp. / 03.2018 / PubMed / Full text
• Blood pressure reactivity to mental stress is attenuated following resistance exercise in older hypertensive women. / 2017 / PubMed / Full text
• Higher levels of myelin phospholipids in brains of neuronal α-Synuclein transgenic mice precede myelin loss. / 08.05.2017 / PubMed / Full text
• Traffic-related air pollution impact on mouse brain accelerates myelin and neuritic aging changes with specificity for CA1 neurons. / 05.2017 / PubMed / Full text
• Postnatal alteration of monocarboxylate transporter 1 expression in the rat corpus callosum. / 04.05.2017 / PubMed / Full text
• Bowel Preparation Is Associated with Reduced Morbidity in Elderly Patients Undergoing Elective Colectomy. / 02.2017 / PubMed / Full text
• Myelin Basic Protein Regulates Primitive and Definitive Neural Stem Cell Proliferation from the Adult Spinal Cord. / 02.2017 / PubMed / Full text
• Isoaspartic acid is present at specific sites in myelin basic protein from multiple sclerosis patients: could this represent a trigger for disease onset? / 12.08.2016 / PubMed / Full text
• Generation of a LacZ reporter transgenic mouse line for the stereological analysis of oligodendrocyte loss in galactosylceramidase deficiency. / 12.2016 / PubMed / Full text
• Loss of Hippocampal Oligodendrocytes Contributes to the Deficit of Contextual Fear Learning in Adult Rats Experiencing Early Bisphenol A Exposure. / 08.2017 / PubMed / Full text
• Aging diminishes the resistance of AO rats to EAE: putative role of enhanced generation of GM-CSF Expressing CD4 T cells in aged rats. / 2015 / PubMed / Full text
• Sleeve Gastrectomy Decreases Body Weight, Whole-Body Adiposity, and Blood Pressure Even in Aged Diet-Induced Obese Rats. / 07.2016 / PubMed / Full text
• Classic and Golli Myelin Basic Protein have distinct developmental trajectories in human visual cortex. / 2015 / PubMed / Full text
• Defective renal dopamine function and sodium-sensitive hypertension in adult ovariectomized Wistar rats: role of the cytochrome P-450 pathway. / 15.06.2015 / PubMed / Full text
• White matter injury and microglia/macrophage polarization are strongly linked with age-related long-term deficits in neurological function after stroke. / 10.2015 / PubMed / Full text
• Age-related changes in spleen of Dark Agouti rats immunized for experimental autoimmune encephalomyelitis. / 15.01.2015 / PubMed / Full text
• Phase separation of myelin sheath in Triton X-114 solution: predominant localization of the 21.5-kDa isoform of myelin basic protein in the lipid raft-associated domain. / 04.2014 / PubMed / Full text

PAH

• Changes in light absorption by brown carbon in soot particles due to heterogeneous ozone aging in a smog chamber. / 11.2020 / PubMed / Full text
• Factors associated with pulmonary arterial hypertension (PAH) in systemic sclerosis (SSc). / 09.2020 / PubMed / Full text
• Potentially Avoidable Hospitalization among Long-Term Care Insurance Beneficiaries with Dementia. / 09.2020 / PubMed / Full text
• Burden of disease at the same limit of exposure to airborne polycyclic aromatic hydrocarbons varies significantly across countries depending on the gap in longevity. / 30.09.2019 / PubMed / Full text
• Converging Paths of Pulmonary Arterial Hypertension and Cellular Senescence. / 07.2019 / PubMed / Full text
• Furanoflavones pongapin and lanceolatin B blocks the cell cycle and induce senescence in CYP1A1-overexpressing breast cancer cells. / 15.12.2018 / PubMed / Full text
• Exposure to Polycyclic Aromatic Hydrocarbons and Accelerated DNA Methylation Aging. / 06.2018 / PubMed / Full text
• Arrhythmias in adult patients with congenital heart disease and pulmonary arterial hypertension. / 12.2018 / PubMed / Full text
• Reduced bioavailability and plant uptake of polycyclic aromatic hydrocarbons from soil slurry amended with biochars pyrolyzed under various temperatures. / 06.2018 / PubMed / Full text
• Early-life exposure to three size-fractionated ultrafine and fine atmospheric particulates in Beijing exacerbates asthma development in mature mice. / 14.03.2018 / PubMed / Full text
• Changes of total and freely dissolved polycyclic aromatic hydrocarbons and toxicity of biochars treated with various aging processes. / 06.2018 / PubMed / Full text
• Bioaccessibility of PAHs and PAH derivatives in a fuel soot assessed by an in vitro digestive model with absorptive sink: Effects of aging the soot in a soil-water mixture. / 15.02.2018 / PubMed / Full text
• Airborne polycyclic aromatic hydrocarbons trigger human skin cells aging through aryl hydrocarbon receptor. / 01.07.2017 / PubMed / Full text
• DNA integrity-protecting and survival-promoting activity of serotonergic system in sturgeon juveniles and sazans. / 08.2017 / PubMed / Full text
• Disruption of phenylalanine hydroxylase reduces adult lifespan and fecundity, and impairs embryonic development in parthenogenetic pea aphids. / 03.10.2016 / PubMed / Full text
• Hepatic Responses of Juvenile Fundulus heteroclitus from Pollution-adapted and Nonadapted Populations Exposed to Elizabeth River Sediment Extract. / 07.2016 / PubMed / Full text
• Non-muscle myosin light chain promotes endothelial progenitor cells senescence and dysfunction in pulmonary hypertensive rats through up-regulation of NADPH oxidase. / 15.03.2016 / PubMed / Full text
• Maintaining lung health with longstanding HIV. / 02.2016 / PubMed / Full text
• Selective enhancement of endothelial BMPR-II with BMP9 reverses pulmonary arterial hypertension. / 07.2015 / PubMed / Full text
• Pulmonary arterial hypertension in rats due to age-related arginase activation in intermittent hypoxia. / 08.2015 / PubMed / Full text
• Symptom Prevalence, Symptom Severity, and Health-Related Quality of Life Among Young, Middle, and Older Adults With Pulmonary Arterial Hypertension. / 04.2016 / PubMed / Full text
• Plasma concentrations of tadalafil in children with pulmonary arterial hypertension. / 10.2014 / PubMed / Full text

TST

• H S Donors Reverse Age-Related Gastric Malfunction Impaired Due to Fructose-Induced Injury [i]via[/i] CBS, CSE, and TST Expression. / 2020 / PubMed / Full text
• Adaptations in mechanical muscle function, muscle morphology, and aerobic power to high-intensity endurance training combined with either traditional or power strength training in older adults: a randomized clinical trial. / 05.2020 / PubMed / Full text
• Digital phenotyping by consumer wearables identifies sleep-associated markers of cardiovascular disease risk and biological aging. / 2019 / PubMed / Full text
• Objective Sleep Duration in Older Adults: Results From The Irish Longitudinal Study on Ageing. / 01.2020 / PubMed / Full text
• Subjective Cognitive Decline and Nighttime Sleep Alterations, a Longitudinal Analysis. / 2019 / PubMed / Full text
• Validity Evaluation of the Fitbit Charge2 and the Garmin vivosmart HR in Free-Living Environments in an Older Adult Cohort. / 19.06.2019 / PubMed / Full text
• Paradoxical effect of testosterone supplementation therapy on cardiac ischemia/reperfusion injury in aged rats. / 07.2019 / PubMed / Full text
• Sleep Disturbances and Risk of Hospitalization and Inpatient Days Among Older Women. / 01.04.2017 / PubMed / Full text
• Relationships between [i]FTO[/i] rs9939609, [i]MC4R[/i] rs17782313, and [i]PPARγ[/i] rs1801282 polymorphisms and the occurrence of selected metabolic and hormonal disorders in middle-aged and elderly men - a preliminary study. / 2016 / PubMed / Full text
• Rest-Activity Patterns in Older Adults with Heart Failure and Healthy Older Adults. / 01.2017 / PubMed / Full text
• The impact of BCG vaccination on tuberculin skin test responses in children is age dependent: evidence to be considered when screening children for tuberculosis infection. / 10.2016 / PubMed / Full text
• The relation between polysomnography and subjective sleep and its dependence on age - poor sleep may become good sleep. / 10.2016 / PubMed / Full text
• Association between physiological falls risk and physical performance tests among community-dwelling older adults. / 2015 / PubMed / Full text
• Anthropometric reference data for elderly Swedes and its disease-related pattern. / 09.2015 / PubMed / Full text
• Impact of maternal melatonin suppression on forced swim and tail suspension behavioral despair tests in adult offspring. / 04-06.2015 / PubMed / Full text
• Controversies in testosterone supplementation therapy. / 03-04.2015 / PubMed / Full text
• Diagnosis and management of testosterone deficiency. / 03-04.2015 / PubMed / Full text
• Testosterone replacement therapy: who to evaluate, what to use, how to follow, and who is at risk? / 12.2014 / PubMed / Full text
• An Overview of Testosterone Therapy. / 01.2016 / PubMed / Full text
• Associations of objectively and subjectively measured sleep quality with subsequent cognitive decline in older community-dwelling men: the MrOS sleep study. / 01.04.2014 / PubMed / Full text
• Chronotype, bed timing and total sleep time in seniors. / 06.2014 / PubMed / Full text
• Telomere length is associated with sleep duration but not sleep quality in adults with human immunodeficiency virus. / 01.01.2014 / PubMed / Full text

BAX

• Clearance of therapy-induced senescent tumor cells by the senolytic ABT-263 via interference with BCL-X -BAX interaction. / 10.2020 / PubMed / Full text
• CREB Signaling Mediates Dose-Dependent Radiation Response in the Murine Hippocampus Two Years after Total Body Exposure. / 03.01.2020 / PubMed / Full text
• Reduced sucrose nonfermenting AMPK-related kinase (SNARK) activity aggravates cancer-induced skeletal muscle wasting. / 09.2019 / PubMed / Full text
• Modulated electro-hyperthermia induced p53 driven apoptosis and cell cycle arrest additively support doxorubicin chemotherapy of colorectal cancer in vitro. / 08.2019 / PubMed / Full text
• The Clearance Effect of Tetrahedral DNA Nanostructures on Senescent Human Dermal Fibroblasts. / 16.01.2019 / PubMed / Full text
• Premature placental aging in term small-for-gestational-age and growth-restricted fetuses. / 05.2019 / PubMed / Full text
• Regulation of apoptosis and autophagy in mouse and human skeletal muscle with aging and lifelong exercise training. / 01.10.2018 / PubMed / Full text
• Xanthohumol exerts protective effects in liver alterations associated with aging. / 03.2019 / PubMed / Full text
• Protective effect of xanthohumol against age-related brain damage. / 11.2017 / PubMed / Full text
• [Inula Britannica flower total flavonoids reduces the apoptosis of aging bone marrow mesenchymal stem cells by anti-oxidation]. / 05.2017 / PubMed
• Hilar granule cells of the mouse dentate gyrus: effects of age, septotemporal location, strain, and selective deletion of the proapoptotic gene BAX. / 09.2017 / PubMed / Full text
• p16 enhances the transcriptional and the apoptotic functions of p53 through DNA-dependent interaction. / 07.2017 / PubMed / Full text
• Protective effects of high Tryptophan diet on aging-induced passive avoidance impairment and hippocampal apoptosis. / 01.2017 / PubMed / Full text
• Mechanisms of Heshouwuyin in regulating apoptosis of testicular cells in aging rats through mitochondrial pathway. / 01.09.2016 / PubMed / Full text
• Response of BAX, Bcl-2 Proteins, and SIRT1/PGC-1α mRNA Expression to 8-Week Treadmill Running in the Aging Rat Skeletal Muscle. / 2016 / PubMed / Full text
• Sperm-associated antigen 9 (SPAG9) promotes the survival and tumor growth of triple-negative breast cancer cells. / 10.2016 / PubMed / Full text
• Apoptosis in young and old denervated rat skeletal muscle. / 02.2017 / PubMed / Full text
• Amelioration of neuronal cell death in a spontaneous obese rat model by dietary restriction through modulation of ubiquitin proteasome system. / 07.2016 / PubMed / Full text
• Melatonin decreases the expression of inflammation and apoptosis markers in the lung of a senescence-accelerated mice model. / 03.2016 / PubMed / Full text
• Melatonin Counteracts at a Transcriptional Level the Inflammatory and Apoptotic Response Secondary to Ischemic Brain Injury Induced by Middle Cerebral Artery Blockade in Aging Rats. / 2015 / PubMed / Full text
• The effect of aging on mitochondrial and cytosolic hepatic intrinsic death pathway and apoptosis associated proteins in Fischer 344 rats. / 07.2015 / PubMed / Full text

CCR2

• Hip Fracture Leads to Transitory Immune Imprint in Older Patients. / 2020 / PubMed / Full text
• The CC-chemokine receptor 2 is involved in the control of ovarian folliculogenesis and fertility lifespan in mice. / 09.2020 / PubMed / Full text
• Deficit of resolution receptor magnifies inflammatory leukocyte directed cardiorenal and endothelial dysfunction with signs of cardiomyopathy of obesity. / 08.2020 / PubMed / Full text
• Tet2-mediated clonal hematopoiesis in nonconditioned mice accelerates age-associated cardiac dysfunction. / 26.03.2020 / PubMed / Full text
• Inflammation and Ectopic Fat Deposition in the Aging Murine Liver Is Influenced by CCR2. / 02.2020 / PubMed / Full text
• Klotho-mediated targeting of CCL2 suppresses the induction of colorectal cancer progression by stromal cell senescent microenvironments. / 11.2019 / PubMed / Full text
• Aging induces cardiac mesenchymal stromal cell senescence and promotes endothelial cell fate of the CD90   subset. / 10.2019 / PubMed / Full text
• Commensal bacteria contribute to insulin resistance in aging by activating innate B1a cells. / 14.11.2018 / PubMed / Full text
• Persistent Infiltration and Impaired Response of Peripherally-Derived Monocytes after Traumatic Brain Injury in the Aged Brain. / 30.05.2018 / PubMed / Full text
• Cryopreserved whole blood for the quantification of monocyte, T-cell and NK-cell subsets, and monocyte receptor expression by multi-color flow cytometry: A methodological study based on participants from the canadian longitudinal study on aging. / 05.2018 / PubMed / Full text
• Inhibition of Radiation-Induced Ccl2 Signaling Protects Lungs from Vascular Dysfunction and Endothelial Cell Loss. / 10.01.2019 / PubMed / Full text
• Attenuated Macrophage Infiltration in Glomeruli of Aged Mice Resulting in Ameliorated Kidney Injury in Nephrotoxic Serum Nephritis. / 10.08.2018 / PubMed / Full text
• Distinct Functions of Senescence-Associated Immune Responses in Liver Tumor Surveillance and Tumor Progression. / 10.10.2016 / PubMed / Full text
• Absence of CCR2 results in an inflammaging environment in young mice with age-independent impairments in muscle regeneration. / 11.2016 / PubMed / Full text
• Long-lived self-renewing bone marrow-derived macrophages displace embryo-derived cells to inhabit adult serous cavities. / 13.06.2016 / PubMed / Full text
• Age exacerbates the CCR2/5-mediated neuroinflammatory response to traumatic brain injury. / 18.04.2016 / PubMed / Full text
• Enhanced Ccl2-Ccr2 signaling drives more severe choroidal neovascularization with aging. / 04.2016 / PubMed / Full text
• Alterations in Monocyte Phenotypes and Functions after a Hip Fracture in Elderly Individuals: A 6-Month Longitudinal Study. / 2016 / PubMed / Full text
• TNF Drives Monocyte Dysfunction with Age and Results in Impaired Anti-pneumococcal Immunity. / 01.2016 / PubMed / Full text
• Senescent dermal fibroblasts enhance stem cell migration through CCL2/CCR2 axis. / 07.2015 / PubMed / Full text
• Differential expression of monocyte surface markers among TB patients with diabetes co-morbidity. / 12.2013 / PubMed / Full text

CD40

• The Regulatory Status Adopted by Lymph Node Dendritic Cells and T Cells During Healthy Aging Is Maintained During Cancer and May Contribute to Reduced Responses to Immunotherapy. / 2018 / PubMed / Full text
• Age-Related Changes on CD40 Promotor Methylation and Immune Gene Expressions in Thymus of Chicken. / 2018 / PubMed / Full text
• Macrophage Depletion in Elderly Mice Improves Response to Tumor Immunotherapy, Increases Anti-tumor T Cell Activity and Reduces Treatment-Induced Cachexia. / 2018 / PubMed / Full text
• One-Year Consumption of a Mediterranean-Like Dietary Pattern With Vitamin D3 Supplements Induced Small Scale but Extensive Changes of Immune Cell Phenotype, Co-receptor Expression and Innate Immune Responses in Healthy Elderly Subjects: Results From the United Kingdom Arm of the NU-AGE Trial. / 2018 / PubMed / Full text
• Membrane-Bound CD40L Promotes Senescence and Initiates Senescence-Associated Secretory Phenotype via NF-κB Activation in Lung Adenocarcinoma. / 2018 / PubMed / Full text
• Effects of Immunosenescence on the Lower Expression of Surface Molecules in Neutrophils and Lymphocytes. / 2018 / PubMed / Full text
• Aerobic Exercise Protects from Pseudomonas aeruginosa-Induced Pneumonia in Elderly Mice. / 2018 / PubMed / Full text
• Elderly dendritic cells respond to LPS/IFN-γ and CD40L stimulation despite incomplete maturation. / 2018 / PubMed / Full text
• C-Reactive Protein Impairs Dendritic Cell Development, Maturation, and Function: Implications for Peripheral Tolerance. / 2018 / PubMed / Full text
• Immunoglobulin therapy ameliorates the phenotype and increases lifespan in the severely affected dystrophin-utrophin double knockout mice. / 12.2017 / PubMed / Full text
• Age-Associated B Cells Express a Diverse Repertoire of V and Vκ Genes with Somatic Hypermutation. / 01.03.2017 / PubMed / Full text
• Autoimmune manifestations in aged mice arise from early-life immune dysregulation. / 19.10.2016 / PubMed / Full text
• The age-related neuroinflammatory environment promotes macrophage activation, which negatively impacts synaptic function. / 07.2016 / PubMed / Full text
• Combinatorial approach to cancer immunotherapy: strength in numbers. / 08.2016 / PubMed / Full text
• Human mesothelioma induces defects in dendritic cell numbers and antigen-processing function which predict survival outcomes. / 02.2016 / PubMed / Full text
• Skewing of peritoneal resident macrophages toward M1-like is involved in enhancement of inflammatory responses induced by secondary necrotic neutrophils in aged mice. / 06-07.2016 / PubMed / Full text
• Blood-borne biomarkers of mortality risk: systematic review of cohort studies. / 2015 / PubMed / Full text
• Age-associated modifications of intestinal permeability and innate immunity in human small intestine. / 10.2015 / PubMed / Full text
• Obesity superimposed on aging magnifies inflammation and delays the resolving response after myocardial infarction. / 15.02.2015 / PubMed / Full text
• Maturation of innate responses to mycobacteria over the first nine months of life. / 15.05.2014 / PubMed / Full text
• IL-2/CD40-activated macrophages rescue age and tumor-induced T cell dysfunction in elderly mice. / 06.2014 / PubMed / Full text

ELOVL2

• ELOVL2: Not just a biomarker of aging. / 2020 / PubMed / Full text
• The lipid elongation enzyme ELOVL2 is a molecular regulator of aging in the retina. / 02.2020 / PubMed / Full text
• Human aging DNA methylation signatures are conserved but accelerated in cultured fibroblasts. / 10.2019 / PubMed / Full text
• Cell and tissue type independent age-associated DNA methylation changes are not rare but common. / 27.11.2018 / PubMed / Full text
• DNA methylation of the ELOVL2, FHL2, KLF14, C1orf132/MIR29B2C, and TRIM59 genes for age prediction from blood, saliva, and buccal swab samples. / 01.2019 / PubMed / Full text
• Proof of concept study of age-dependent DNA methylation markers across different tissues by massive parallel sequencing. / 09.2018 / PubMed / Full text
• Age-related DNA methylation changes are tissue-specific with ELOVL2 promoter methylation as exception. / 30.05.2018 / PubMed / Full text
• DNA methylation levels in candidate genes associated with chronological age in mammals are not conserved in a long-lived seabird. / 2017 / PubMed / Full text
• Chronological age prediction based on DNA methylation: Massive parallel sequencing and random forest regression. / 11.2017 / PubMed / Full text
• DNA methylation in ELOVL2 and C1orf132 correctly predicted chronological age of individuals from three disease groups. / 01.2018 / PubMed / Full text
• Independent validation of DNA-based approaches for age prediction in blood. / 07.2017 / PubMed / Full text
• Genome-wide DNA methylation analysis reveals hypomethylation in the low-CpG promoter regions in lymphoblastoid cell lines. / 12.05.2017 / PubMed / Full text
• Systemic Age-Associated DNA Hypermethylation of ELOVL2 Gene: In Vivo and In Vitro Evidences of a Cell Replication Process. / 01.08.2017 / PubMed / Full text
• Donor age and C1orf132/MIR29B2C determine age-related methylation signature of blood after allogeneic hematopoietic stem cell transplantation. / 2016 / PubMed / Full text
• Forensic age prediction for dead or living samples by use of methylation-sensitive high resolution melting. / 07.2016 / PubMed / Full text
• Development of a methylation marker set for forensic age estimation using analysis of public methylation data and the Agena Bioscience EpiTYPER system. / 09.2016 / PubMed / Full text
• Age-associated changes in DNA methylation across multiple tissues in an inbred mouse model. / 03.2016 / PubMed / Full text
• Aging-associated DNA methylation changes in middle-aged individuals: the Young Finns study. / 09.02.2016 / PubMed / Full text
• Improved age determination of blood and teeth samples using a selected set of DNA methylation markers. / 2015 / PubMed / Full text
• Development of a forensically useful age prediction method based on DNA methylation analysis. / 07.2015 / PubMed / Full text
• Genome-wide age-related changes in DNA methylation and gene expression in human PBMCs. / 06.2014 / PubMed / Full text

REST

• [Brain and Neuronal Aging: Aged Brain Controls via Gene Expression Fidelity and Master Regulatory Factors]. / 2020 / PubMed / Full text
• Effect of 9 - PAHSA on cognitive dysfunction in diabetic mice and its possible mechanism. / 09.04.2020 / PubMed / Full text
• Increased REST to Optimize Life Span? / 12.2019 / PubMed / Full text
• Cardiac baroreflex hysteresis is one of the determinants of the heart period variability asymmetry. / 01.10.2019 / PubMed / Full text
• Pterostilbene Improves Cognitive Performance in Aged Rats: An in Vivo Study. / 2019 / PubMed / Full text
• Comparison between probabilistic and Wiener-Granger causality in assessing modifications of the cardiac baroreflex control with age. / 22.10.2018 / PubMed / Full text
• Fast-Evolving Human-Specific Neural Enhancers Are Associated with Aging-Related Diseases. / 23.05.2018 / PubMed / Full text
• Influence of age and gender on the phase and strength of the relation between heart period and systolic blood pressure spontaneous fluctuations. / 01.03.2018 / PubMed / Full text
• Genetic Biomarkers on Age-Related Cognitive Decline. / 2017 / PubMed / Full text
• MicroRNA Expression Analysis of Centenarians and Rheumatoid Arthritis Patients Reveals a Common Expression Pattern. / 2017 / PubMed / Full text
• The rs1277306 Variant of the REST Gene Confers Susceptibility to Cognitive Aging in an Elderly Taiwanese Population. / 2017 / PubMed / Full text
• Assessing the evolution of redundancy/synergy of spontaneous variability regulation with age. / 05.2017 / PubMed / Full text
• Sixty years old is the breakpoint of human frontal cortex aging. / 02.2017 / PubMed / Full text
• Is senescence-associated β-galactosidase a marker of neuronal senescence? / 06.12.2016 / PubMed / Full text
• Running for REST: Physical activity attenuates neuroinflammation in the hippocampus of aged mice. / 03.2017 / PubMed / Full text
• Hippocampal proteomics defines pathways associated with memory decline and resilience in normal aging and Alzheimer's disease mouse models. / 30.03.2017 / PubMed / Full text
• A gain-of-function senescence bypass screen identifies the homeobox transcription factor DLX2 as a regulator of ATM-p53 signaling. / 01.02.2016 / PubMed / Full text
• An integrative multi-scale analysis of the dynamic DNA methylation landscape in aging. / 02.2015 / PubMed / Full text
• MicroRNA-9 controls dendritic development by targeting REST. / 18.11.2014 / PubMed / Full text
• Rcor2 underexpression in senescent mice: a target for inflammaging? / 23.07.2014 / PubMed / Full text
• REST and stress resistance in ageing and Alzheimer's disease. / 27.03.2014 / PubMed / Full text

SIRT7

• SIRT7 antagonizes human stem cell aging as a heterochromatin stabilizer. / 07.2020 / PubMed / Full text
• Spatio-temporal expression profile of sirtuins during aging of the annual fish Nothobranchius furzeri. / 09.2019 / PubMed / Full text
• Advances in Cellular Characterization of the Sirtuin Isoform, SIRT7. / 2018 / PubMed / Full text
• The epigenetic regulator SIRT7 guards against mammalian cellular senescence induced by ribosomal DNA instability. / 13.07.2018 / PubMed / Full text
• Differential gene expression of sirtuins between somatotropinomas and nonfunctioning pituitary adenomas. / 08.2018 / PubMed / Full text
• Analysis of Polymorphisms in 59 Potential Candidate Genes for Association With Human Longevity. / 08.10.2018 / PubMed / Full text
• The effects of graded levels of calorie restriction: XI. Evaluation of the main hypotheses underpinning the life extension effects of CR using the hepatic transcriptome. / 31.07.2017 / PubMed / Full text
• Sirtuin 7 is decreased in pulmonary fibrosis and regulates the fibrotic phenotype of lung fibroblasts. / 01.06.2017 / PubMed / Full text
• The protein-interaction network with functional roles in tumorigenesis, neurodegeneration, and aging. / 12.2016 / PubMed / Full text
• Molecular, Cellular, and Physiological Characterization of Sirtuin 7 (SIRT7). / 2016 / PubMed / Full text
• miR-152 induces human dental pulp stem cell senescence by inhibiting SIRT7 expression. / 04.2016 / PubMed / Full text
• Sirtuins, Cell Senescence, and Vascular Aging. / 05.2016 / PubMed / Full text
• The expression levels of the sirtuins in patients with BCC. / 05.2016 / PubMed / Full text
• Age-Related Changes in Sirtuin 7 Expression in Calorie-Restricted and Refed Rats. / 2016 / PubMed / Full text
• Effects of Aging and Cardiovascular Disease Risk Factors on the Expression of Sirtuins in the Human Corpus Cavernosum. / 11.2015 / PubMed / Full text
• Novel protein-protein interactions of TPPII, p53, and SIRT7. / 11.2015 / PubMed / Full text
• Differential expression of sirtuins in the aging rat brain. / 2015 / PubMed / Full text
• Stressed SIRT7: facing a crossroad of senescence and immortality. / 06.2015 / PubMed / Full text
• Sirtuin 7 promotes cellular survival following genomic stress by attenuation of DNA damage, SAPK activation and p53 response. / 01.02.2015 / PubMed / Full text
• A SIRT7-dependent acetylation switch of GABPβ1 controls mitochondrial function. / 04.11.2014 / PubMed / Full text
• Comparative interactomes of SIRT6 and SIRT7: Implication of functional links to aging. / 07.2014 / PubMed / Full text

TEC

• Vestibular function and cortical and sub-cortical alterations in an aging population. / 08.2020 / PubMed / Full text
• Metabolic Flexibility and Innate Immunity in Renal Ischemia Reperfusion Injury: The Fine Balance Between Adaptive Repair and Tissue Degeneration. / 2020 / PubMed / Full text
• Postnatal Involution and Counter-Involution of the Thymus. / 2020 / PubMed / Full text
• Gender Disparity Impacts on Thymus Aging and LHRH Receptor Antagonist-Induced Thymic Reconstitution Following Chemotherapeutic Damage. / 2020 / PubMed / Full text
• Clonogenic Culture of Mouse Thymic Epithelial Cells. / 2019 / PubMed / Full text
• TREM1/3 Deficiency Impairs Tissue Repair After Acute Kidney Injury and Mitochondrial Metabolic Flexibility in Tubular Epithelial Cells. / 2019 / PubMed / Full text
• Interplay between Follistatin, Activin A, and BMP4 Signaling Regulates Postnatal Thymic Epithelial Progenitor Cell Differentiation during Aging. / 25.06.2019 / PubMed / Full text
• Transgenic Exosomes for Thymus Regeneration. / 2019 / PubMed / Full text
• Cell-type-specific role of lamin-B1 in thymus development and its inflammation-driven reduction in thymus aging. / 08.2019 / PubMed / Full text
• Comparison of the Shear Bond Strength of Metal Orthodontic Brackets Bonded to Long-term Water-aged and Fresh Porcelain and Composite Surfaces. / 03.2019 / PubMed / Full text
• Epithelial innate immunity mediates tubular cell senescence after kidney injury. / 24.01.2019 / PubMed / Full text
• Thymic Epithelial Cell Support of Thymopoiesis Does Not Require [i]Klotho[/i]. / 01.12.2018 / PubMed / Full text
• MicroRNAs Regulate Thymic Epithelium in Age-Related Thymic Involution via Down- or Upregulation of Transcription Factors. / 2017 / PubMed / Full text
• A Fine-Tune Role of Mir-125a-5p on [i]Foxn1[/i] During Age-Associated Changes in the Thymus. / 05.2017 / PubMed / Full text
• Mechanisms and kinetics of proliferation and fibrosis development in a mouse model of thyrocyte hyperplasia. / 06-07.2016 / PubMed / Full text
• Foxn1 Is Dynamically Regulated in Thymic Epithelial Cells during Embryogenesis and at the Onset of Thymic Involution. / 2016 / PubMed / Full text
• Foxn1 Protein Expression in the Developing, Aging, and Regenerating Thymus. / 15.12.2015 / PubMed / Full text
• Young, proliferative thymic epithelial cells engraft and function in aging thymuses. / 15.05.2015 / PubMed / Full text
• Regeneration of the aged thymus by a single transcription factor. / 04.2014 / PubMed / Full text
• Meis1 is required for the maintenance of postnatal thymic epithelial cells. / 2014 / PubMed / Full text
• Identification of novel thymic epithelial cell subsets whose differentiation is regulated by RANKL and Traf6. / 2014 / PubMed / Full text

C6

• Evolution of the Aroma of Treixadura Wines during Bottle Aging. / 08.10.2020 / PubMed / Full text
• D-galactose induces senescence of glioblastoma cells through YAP-CDK6 pathway. / 29.09.2020 / PubMed / Full text
• Alcohol Extracts From [i]Ganoderma lucidum[/i] Delay the Progress of Alzheimer's Disease by Regulating DNA Methylation in Rodents. / 2019 / PubMed / Full text
• Age and Sex-Associated Changes of Complement Activity and Complement Levels in a Healthy Caucasian Population. / 2018 / PubMed / Full text
• Population-Stratified Analysis of Bone Mineral Density Distribution in Cervical and Lumbar Vertebrae of Chinese from Quantitative Computed Tomography. / 09-10.2016 / PubMed / Full text
• Demographic aspects in cervical vertebral bodies' size and shape (C3-C7): a skeletal study. / 01.2017 / PubMed / Full text
• Neonatal Benzo[a]pyrene Exposure Induces Oxidative Stress and DNA Damage Causing Neurobehavioural Changes during the Early Adolescence Period in Rats. / 2016 / PubMed / Full text
• Variations in Occipitocervical and Cervicothoracic Alignment Parameters Based on Age: A Prospective Study of Asymptomatic Volunteers Using Full-Body Radiographs. / 01.12.2016 / PubMed / Full text
• Age-related brain atrophy may be mitigated by internal jugular vein enlargement in male individuals without neurologic disease. / 03.2017 / PubMed / Full text
• The incidence of cervical spondylosis decreases with aging in the elderly, and increases with aging in the young and adult population: a hospital-based clinical analysis. / 2016 / PubMed / Full text
• Depletion of B cell CLL/Lymphoma 11B Gene Expression Represses Glioma Cell Growth. / 08.2016 / PubMed / Full text
• Are the standard parameters of cervical spine alignment and range of motion related to age, sex, and cervical disc degeneration? / 09.2015 / PubMed / Full text
• Age-related morphologic changes of the vertebral artery in the transverse process. Analysis by multidetector computed tomography angiography. / 01.09.2015 / PubMed / Full text
• Role of the serotonin transporter gene locus in the response to SSRI treatment of major depressive disorder in late life. / 05.2015 / PubMed / Full text
• The Impact of Genetics on Physical Resilience and Successful Aging. / 09.2015 / PubMed / Full text
• Intake of low-dose leucine-rich essential amino acids stimulates muscle anabolism equivalently to bolus whey protein in older women at rest and after exercise. / 15.06.2015 / PubMed / Full text
• Non-sirtuin histone deacetylases in the control of cardiac aging. / 06.2015 / PubMed / Full text
• Engineering temporal accumulation of a low recalcitrance polysaccharide leads to increased C6 sugar content in plant cell walls. / 09.2015 / PubMed / Full text
• The effects of age on the morphometry of the cervical spinal cord and spinal column in adult rats: an MRI-based study. / 10.2014 / PubMed / Full text
• Spontaneous age-related cervical disc degeneration in the sand rat. / 06.2014 / PubMed / Full text

C7

• The Vertebral Artery Convergence to the Cervical Spine in Elders. / 30.09.2019 / PubMed / Full text
• Age-related Changes in Cervical Sagittal Alignment: A Radiographic Analysis. / 01.10.2019 / PubMed / Full text
• Early Intravenous Infusion of Mesenchymal Stromal Cells Exerts a Tissue Source Age-Dependent Beneficial Effect on Neurovascular Integrity and Neurobehavioral Recovery After Traumatic Cervical Spinal Cord Injury. / 07.2019 / PubMed / Full text
• Age and Sex-Associated Changes of Complement Activity and Complement Levels in a Healthy Caucasian Population. / 2018 / PubMed / Full text
• Twenty-year Longitudinal Follow-up MRI Study of Asymptomatic Volunteers: The Impact of Cervical Alignment on Disk Degeneration. / 12.2018 / PubMed / Full text
• The change of cervical spine alignment along with aging in asymptomatic population: a preliminary analysis. / 09.2017 / PubMed / Full text
• Lumbar Retrolisthesis in Aging Spine: What are the Associated Factors? / 07.2017 / PubMed / Full text
• Three types of sagittal alignment regarding compensation in asymptomatic adults: the contribution of the spine and lower limbs. / 02.2018 / PubMed / Full text
• Age-related variations in global spinal alignment and sagittal balance in asymptomatic Japanese adults. / 05.2017 / PubMed / Full text
• Standing sagittal alignment of the whole axial skeleton with reference to the gravity line in humans. / 05.2017 / PubMed / Full text
• Population-Stratified Analysis of Bone Mineral Density Distribution in Cervical and Lumbar Vertebrae of Chinese from Quantitative Computed Tomography. / 09-10.2016 / PubMed / Full text
• Demographic aspects in cervical vertebral bodies' size and shape (C3-C7): a skeletal study. / 01.2017 / PubMed / Full text
• Prediction of Cervical Endplate Size: One Size Does Not Fit All. / 01.05.2016 / PubMed / Full text
• Variations in Occipitocervical and Cervicothoracic Alignment Parameters Based on Age: A Prospective Study of Asymptomatic Volunteers Using Full-Body Radiographs. / 01.12.2016 / PubMed / Full text
• Age-related brain atrophy may be mitigated by internal jugular vein enlargement in male individuals without neurologic disease. / 03.2017 / PubMed / Full text
• The incidence of cervical spondylosis decreases with aging in the elderly, and increases with aging in the young and adult population: a hospital-based clinical analysis. / 2016 / PubMed / Full text
• Signal intensity loss of the intervertebral discs in the cervical spine of young patients on fluid sensitive sequences. / 03.2016 / PubMed / Full text
• The Cervical Spinal Canal Tapers Differently in Patients with Chiari I with and without Syringomyelia. / 04.2016 / PubMed / Full text
• Corticospinal tract development and spinal cord innervation differ between cervical and lumbar targets. / 21.01.2015 / PubMed / Full text
• Spontaneous age-related cervical disc degeneration in the sand rat. / 06.2014 / PubMed / Full text

CDKN2A

• Association between Nrf2 and CDKN2A expression in patients with end-stage renal disease: a pilot study. / 13.07.2020 / PubMed / Full text
• Analysis of somatic mutations identifies signs of selection during in vitro aging of primary dermal fibroblasts. / 12.2019 / PubMed / Full text
• Analysis of the putative tumor suppressor gene cdkn2ab in pigment cells and melanoma of Xiphophorus and medaka. / 03.2019 / PubMed / Full text
• In vitro behavior and UV response of melanocytes derived from carriers of [[CDKN2A]] mutations and MC1R variants. / 03.2019 / PubMed / Full text
• Endothelial PPARγ (Peroxisome Proliferator-Activated Receptor-γ) Is Essential for Preventing Endothelial Dysfunction With Aging. / 07.2018 / PubMed / Full text
• Upregulation of lactate-inducible snail protein suppresses oncogene-mediated senescence through p16 inactivation. / 26.02.2018 / PubMed / Full text
• Cellular aging dynamics after acute malaria infection: A 12-month longitudinal study. / 02.2018 / PubMed / Full text
• ARID1A suppresses malignant transformation of human pancreatic cells via mediating senescence-associated miR-503/[[CDKN2A]] regulatory axis. / 18.11.2017 / PubMed / Full text
• Cellular Senescence in Mouse Hippocampus After Irradiation and the Role of p53 and p21. / 01.04.2017 / PubMed / Full text
• Identification of the activating cytotoxicity receptor NKG2D as a senescence marker in zero-hour kidney biopsies is indicative for clinical outcome. / 06.2017 / PubMed / Full text
• ETS Proto-oncogene 1 Transcriptionally Up-regulates the Cholangiocyte Senescence-associated Protein Cyclin-dependent Kinase Inhibitor 2A. / 24.03.2017 / PubMed / Full text
• Establishment and application of a novel patient-derived KIAA1549:BRAF-driven pediatric pilocytic astrocytoma model for preclinical drug testing. / 14.02.2017 / PubMed / Full text
• Induction of DNA double-strand breaks and cellular senescence by human respiratory syncytial virus. / 18.05.2016 / PubMed / Full text
• Targeting genes in insulin-associated signalling pathway, DNA damage, cell proliferation and cell differentiation pathways by tocotrienol-rich fraction in preventing cellular senescence of human diploid fibroblasts. / 11-12.2015 / PubMed / Full text
• Alterations of telomere length and DNA methylation in hairdressers: A cross-sectional study. / 03.2016 / PubMed / Full text
• Genetics of melanoma progression: the rise and fall of cell senescence. / 03.2016 / PubMed / Full text
• Defective autophagy in vascular smooth muscle cells accelerates senescence and promotes neointima formation and atherogenesis. / 02.11.2015 / PubMed / Full text
• Genomic regulation of senescence and innate immunity signaling in the retinal pigment epithelium. / 06.2015 / PubMed / Full text
• Y-27632, a ROCK inhibitor, delays senescence of putative murine salivary gland stem cells in culture. / 06.2015 / PubMed / Full text
• Coordinated control of senescence by lncRNA and a novel T-box3 co-repressor complex. / 29.05.2014 / PubMed / Full text

CXCL1

• Contusion spinal cord injury upregulates p53 protein expression in rat soleus muscle at multiple timepoints but not key senescence cytokines. / 02.2020 / PubMed / Full text
• Systemic Inflammation and the Increased Risk of Inflamm-Aging and Age-Associated Diseases in People Living With HIV on Long Term Suppressive Antiretroviral Therapy. / 2019 / PubMed / Full text
• Inflammatory and Senescent Phenotype of Pancreatic Stellate Cells Induced by Sqstm1 Downregulation Facilitates Pancreatic Cancer Progression. / 2019 / PubMed / Full text
• Neuroprotective effects of targeting BET proteins for degradation with dBET1 in aged mice subjected to ischemic stroke. / 07.2019 / PubMed / Full text
• Excessive neutrophil levels in the lung underlie the age-associated increase in influenza mortality. / 03.2019 / PubMed / Full text
• Prophylactic Palmitoylethanolamide Prolongs Survival and Decreases Detrimental Inflammation in Aged Mice With Bacterial Meningitis. / 2018 / PubMed / Full text
• The Role of Pulmonary and Systemic Immunosenescence in Acute Lung Injury. / 08.2018 / PubMed / Full text
• Urine Cytokine and Chemokine Levels Predict Urinary Tract Infection Severity Independent of Uropathogen, Urine Bacterial Burden, Host Genetics, and Host Age. / 09.2018 / PubMed / Full text
• Aerobic Exercise Protects from Pseudomonas aeruginosa-Induced Pneumonia in Elderly Mice. / 2018 / PubMed / Full text
• Infiltrating macrophages contribute to age-related neuroinflammation in C57/BL6 mice. / 07.2018 / PubMed / Full text
• Time-Dependent Changes in Local and Serum Levels of Inflammatory Cytokines as Markers for Incised Wound Aging of Skeletal Muscles. / 05.2018 / PubMed / Full text
• Age-related decline of the acute local inflammation response: a mitigating role for the adenosine A receptor. / 18.10.2017 / PubMed / Full text
• IFN-γ induces senescence-like characteristics in mouse bone marrow mesenchymal stem cells. / 03-04.2017 / PubMed / Full text
• Methyl caffeate and some plant constituents inhibit age-related inflammation: effects on senescence-associated secretory phenotype (SASP) formation. / 04.2017 / PubMed / Full text
• Adiponectin induces CXCL1 secretion from cancer cells and promotes tumor angiogenesis by inducing stromal fibroblast senescence. / 11.2016 / PubMed / Full text
• Senescent peritoneal mesothelium induces a pro-angiogenic phenotype in ovarian cancer cells in vitro and in a mouse xenograft model in vivo. / 01.2016 / PubMed / Full text
• CXCL1 Triggers Caspase-3 Dependent Tau Cleavage in Long-Term Neuronal Cultures and in the Hippocampus of Aged Mice: Implications in Alzheimer's Disease. / 2015 / PubMed / Full text
• Effects of flavonoids on senescence-associated secretory phenotype formation from bleomycin-induced senescence in BJ fibroblasts. / 15.08.2015 / PubMed / Full text
• Microglial Kv1.3 Channels and P2Y12 Receptors Differentially Regulate Cytokine and Chemokine Release from Brain Slices of Young Adult and Aged Mice. / 2015 / PubMed / Full text
• Cathelicidin related antimicrobial peptide, laminin, Toll-like receptors and chemokines levels in experimental hypersensitivity pneumonitis in mice. / 06.2015 / PubMed / Full text

CXCR4

• Aging-Related Reduced Expression of CXCR4 on Bone Marrow Mesenchymal Stromal Cells Contributes to Hematopoietic Stem and Progenitor Cell Defects. / 08.2020 / PubMed / Full text
• Transfer of a human gene variant associated with exceptional longevity improves cardiac function in obese type 2 diabetic mice through induction of the SDF-1/CXCR4 signalling pathway. / 09.2020 / PubMed / Full text
• Stromal Cell-Derived Factor 1 Protects Brain Vascular Endothelial Cells from Radiation-Induced Brain Damage. / 10.10.2019 / PubMed / Full text
• A Neutrophil Timer Coordinates Immune Defense and Vascular Protection. / 19.02.2019 / PubMed / Full text
• Novel molecular mechanisms for the adaptogenic effects of herbal extracts on isolated brain cells using systems biology. / 15.11.2018 / PubMed / Full text
• Reducing CXCR4 Resulted in Impairing Proliferation and Promoting Aging. / 2018 / PubMed / Full text
• Targeting junctional adhesion molecule-C ameliorates sepsis-induced acute lung injury by decreasing CXCR4 aged neutrophils. / 12.2018 / PubMed / Full text
• Tumor microenvironment in functional adrenocortical adenomas: immune cell infiltration in cortisol-producing adrenocortical adenoma. / 07.2018 / PubMed / Full text
• Lower resting and exercise-induced circulating angiogenic progenitors and angiogenic T cells in older men. / 01.03.2018 / PubMed / Full text
• Adipose-Derived Mesenchymal Stem Cells from the Elderly Exhibit Decreased Migration and Differentiation Abilities with Senescent Properties. / 09.2017 / PubMed / Full text
• Conversion of adult endothelium to immunocompetent haematopoietic stem cells. / 25.05.2017 / PubMed / Full text
• Chronic Resveratrol Treatment Inhibits MRC5 Fibroblast SASP-Related Protumoral Effects on Melanoma Cells. / 01.09.2017 / PubMed / Full text
• The expression of the BPIFB4 and CXCR4 associates with sustained health in long-living individuals from Cilento-Italy. / 22.01.2017 / PubMed / Full text
• Age and Human Regenerative Capacity Impact of Cardiovascular Risk Factors. / 16.09.2016 / PubMed / Full text
• Effect of age on expression of spermatogonial markers in bovine testis and isolated cells. / 07.2016 / PubMed / Full text
• Increased susceptibility of CD4 T cells from elderly individuals to HIV-1 infection and apoptosis is associated with reduced CD4 and enhanced CXCR4 and FAS surface expression levels. / 09.10.2015 / PubMed / Full text
• A single fas gene mutation changes lupus onset, severity, location, and molecular abnormalities in mice. / 2015 / PubMed / Full text
• Caloric restriction and the adipokine leptin alter the SDF-1 signaling axis in bone marrow and in bone marrow derived mesenchymal stem cells. / 15.07.2015 / PubMed / Full text
• CXCR4 blockade induces atherosclerosis by affecting neutrophil function. / 09.2014 / PubMed / Full text
• Trafficking phenotype and production of granzyme B by double negative B cells (IgG( )IgD(-)CD27(-)) in the elderly. / 06.2014 / PubMed / Full text

ERG

• Effect of age and sex on neurodevelopment and neurodegeneration in the healthy eye: Longitudinal functional and structural study in the Long-Evans rat. / 11.2020 / PubMed / Full text
• Mice With a Combined Deficiency of Superoxide Dismutase 1 (Sod1), DJ-1 (Park7), and Parkin (Prkn) Develop Spontaneous Retinal Degeneration With Aging. / 03.09.2019 / PubMed / Full text
• Test-retest repeatability of the pattern electroretinogram and flicker electroretinogram. / 12.2019 / PubMed / Full text
• Regeneration of Dopaminergic Neurons in Adult Zebrafish Depends on Immune System Activation and Differs for Distinct Populations. / 12.06.2019 / PubMed / Full text
• Sirt3 mediates the protective effect of hydrogen in inhibiting ROS-induced retinal senescence. / 01.05.2019 / PubMed / Full text
• Further Characterization of the Predominant Inner Retinal Degeneration of Aging Cln3 Knock-In Mice. / 2018 / PubMed / Full text
• Two novel forms of ERG oscillation in Drosophila: age and activity dependence. / 03-06.2018 / PubMed / Full text
• Loss of XBP1 accelerates age-related decline in retinal function and neurodegeneration. / 04.04.2018 / PubMed / Full text
• The Complement System Is Critical in Maintaining Retinal Integrity during Aging. / 2018 / PubMed / Full text
• EDI OCT evaluation of choroidal thickness in Stargardt disease. / 2018 / PubMed / Full text
• Intensity response function of the photopic negative response (PhNR): effect of age and test-retest reliability. / 08.2017 / PubMed / Full text
• Nonamyloidogenic processing of amyloid beta precursor protein is associated with retinal function improvement in aging male APP /PS1ΔE9 mice. / 05.2017 / PubMed / Full text
• Absence of DJ-1 causes age-related retinal abnormalities in association with increased oxidative stress. / 03.2017 / PubMed / Full text
• Uncoupling neuronal death and dysfunction in Drosophila models of neurodegenerative disease. / 23.06.2016 / PubMed / Full text
• Age-related change in fast adaptation mechanisms measured with the scotopic full-field ERG. / 06.2016 / PubMed / Full text
• Relation of BAALC and ERG Gene Expression with Overall Survival in Acute Myeloid Leukemia Cases. / 2015 / PubMed / Full text
• Differences in Retinal Structure and Function between Aging Male and Female Sprague-Dawley Rats are Strongly Influenced by the Estrus Cycle. / 2015 / PubMed / Full text
• Lack of Acid Sphingomyelinase Induces Age-Related Retinal Degeneration. / 2015 / PubMed / Full text
• Changes in rod and cone-driven oscillatory potentials in the aging human retina. / 17.07.2014 / PubMed / Full text
• The effect of ageing on ocular blood flow, oxygen tension and retinal function during and after intraocular pressure elevation. / 2014 / PubMed / Full text

FES

• An outpatient Tai Chi program: Effects on veterans' functional outcomes. / 26.11.2020 / PubMed / Full text
• Gait Function in Adults Aged 50 Years and Older With Spina Bifida. / 07.11.2020 / PubMed / Full text
• A Single Question as a Screening Tool to Assess Fear of Falling in Young-Old Community-Dwelling Persons. / 09.2020 / PubMed / Full text
• Fall-related efficacy is a useful and independent index to detect fall risk in Japanese community-dwelling older people: a 1-year longitudinal study. / 29.10.2019 / PubMed / Full text
• Investigating Changes in Real-time Conscious Postural Processing by Older Adults during Different Stance Positions Using Electroencephalography Coherence. / 10-12.2019 / PubMed / Full text
• Effectiveness of Daily Use of Bilateral Custom-Made Ankle-Foot Orthoses on Balance, Fear of Falling, and Physical Activity in Older Adults: A Randomized Controlled Trial. / 2019 / PubMed / Full text
• Decline in sensorimotor systems explains reduced falls self-efficacy. / 10.2018 / PubMed / Full text
• Fear of Falling in Older Adults with Diabetes Mellitus: The IMIAS Study. / 09.2018 / PubMed / Full text
• Cross-cultural adaptation and measurement properties testing of the Iconographical Falls Efficacy Scale (Icon-FES). / 07-08.2018 / PubMed / Full text
• Binocular Vision Disorders and Visual Attention: Associations With Balance and Mobility in Older Adults. / 01.04.2018 / PubMed / Full text
• Genome-wide methylation analysis reveals differentially methylated loci that are associated with an age-dependent increase in bovine fibroblast response to LPS. / 25.05.2017 / PubMed / Full text
• FES in Europe and Beyond: Current Translational Research. / 15.09.2016 / PubMed / Full text
• Use it or Lose It: Tonic Activity of Slow Motoneurons Promotes Their Survival and Preferentially Increases Slow Fiber-Type Groupings in Muscles of Old Lifelong Recreational Sportsmen. / 15.09.2016 / PubMed / Full text
• Recovery from muscle weakness by exercise and FES: lessons from Masters, active or sedentary seniors and SCI patients. / 08.2017 / PubMed / Full text
• Biology of Muscle Atrophy and of its Recovery by FES in Aging and Mobility Impairments: Roots and By-Products. / 24.08.2015 / PubMed / Full text
• Balance Disorders in the Elderly: Does Instability Increase Over Time? / 07.2016 / PubMed / Full text
• Age group classification and gender detection based on forced expiratory spirometry. / 08.2015 / PubMed / Full text
• Is there a relationship between short FES-I test scores and objective assessment of balance in the older people with age-induced instability? / 01-02.2016 / PubMed / Full text
• Age-associated declines in muscle mass, strength, power, and physical performance: impact on fear of falling and quality of life. / 02.2016 / PubMed / Full text
• Effects of functional electric stimulation cycle ergometry training on lower limb musculature in acute sci individuals. / 01.09.2005 / PubMed / Full text

JAK2

• Senescence in Monocytes Facilitates Dengue Virus Infection by Increasing Infectivity. / 2020 / PubMed / Full text
• Quercetin Directly Targets JAK2 and PKCδ and Prevents UV-Induced Photoaging in Human Skin. / 23.10.2019 / PubMed / Full text
• [Red blood cell lifespan detected by endogenous carbon monoxide breath test in patients with polycythemia vera]. / 01.10.2019 / PubMed / Full text
• Roles of JAK2 in Aging, Inflammation, Hematopoiesis and Malignant Transformation. / 08.08.2019 / PubMed / Full text
• The mir-465 family is upregulated with age and attenuates growth hormone signaling in mouse liver. / 04.2019 / PubMed / Full text
• Clonal hematopoiesis: Genes and underlying mechanisms in cardiovascular disease development. / 06.2019 / PubMed / Full text
• Distinctive features of polycythaemia vera in New Zealand Polynesians. / 21.09.2018 / PubMed
• Immunologic effects of chronic administration of tofacitinib, a Janus kinase inhibitor, in cynomolgus monkeys and rats - Comparison of juvenile and adult responses. / 04.2018 / PubMed / Full text
• Molecular Pathogenesis of Myeloproliferative Neoplasms: Influence of Age and Gender. / 10.2017 / PubMed / Full text
• Proliferation Drives Aging-Related Functional Decline in a Subpopulation of the Hematopoietic Stem Cell Compartment. / 23.05.2017 / PubMed / Full text
• The Dyslexia-susceptibility Protein KIAA0319 Inhibits Axon Growth Through Smad2 Signaling. / 01.03.2017 / PubMed / Full text
• JAK-STAT signaling mediates the senescence of bone marrow-mesenchymal stem cells from systemic lupus erythematosus patients. / 01.03.2017 / PubMed / Full text
• Oxidative stress induces the decline of brain EPO expression in aging rats. / 10.2016 / PubMed / Full text
• Scribble is required for pregnancy-induced alveologenesis in the adult mammary gland. / 15.06.2016 / PubMed / Full text
• Type I collagen aging impairs discoidin domain receptor 2-mediated tumor cell growth suppression. / 03.05.2016 / PubMed / Full text
• Exogenous H2S contributes to recovery of ischemic post-conditioning-induced cardioprotection by decrease of ROS level via down-regulation of NF-κB and JAK2-STAT3 pathways in the aging cardiomyocytes. / 2016 / PubMed / Full text
• Correlation Analysis Between Expression Levels of Hepatic Growth Hormone Receptor, Janus Kinase 2, Insulin-Like Growth Factor-I Genes and Dwarfism Phenotype in Bama Minipig. / 02.2015 / PubMed / Full text
• Emerging drugs for the treatment of myelofibrosis. / 2015 / PubMed / Full text
• PLA2R1: expression and function in cancer. / 08.2014 / PubMed / Full text
• Adipocyte-specific deficiency of Janus kinase (JAK) 2 in mice impairs lipolysis and increases body weight, and leads to insulin resistance with ageing. / 05.2014 / PubMed / Full text

MMP9

• EGR1 promotes the cartilage degeneration and hypertrophy by activating the Krüppel-like factor 5 and β-catenin signaling. / 01.09.2019 / PubMed / Full text
• [Effect of saponins extracted from Panax japonicas on inhibiting myocardial fibrosis by TGF-β1/Smad3 signaling pathway in aging rats]. / 11.2018 / PubMed / Full text
• Retinoic acid promotes in vitro follicle activation in the cat ovary by regulating expression of matrix metalloproteinase 9. / 2018 / PubMed / Full text
• Oxidative stress induces p38MAPK-dependent senescence in the feto-maternal interface cells. / 07.2018 / PubMed / Full text
• Activation of DNA demethylases attenuates aging-associated arterial stiffening and hypertension. / 08.2018 / PubMed / Full text
• Fibronectin Containing Extra Domain A Induces Plaque Destabilization in the Innominate Artery of Aged Apolipoprotein E-Deficient Mice. / 03.2018 / PubMed / Full text
• Timing and duration of nursing from birth affect neonatal porcine uterine matrix metalloproteinase 9 and tissue inhibitor of metalloproteinase 1. / 04.2017 / PubMed / Full text
• Secondhand Smoke Exposure Enhances Cardiac Fibrosis Effects on the Aging Rat Hearts. / 09.2016 / PubMed / Full text
• Transcriptome Analysis of B Cell Immune Functions in Periodontitis: Mucosal Tissue Responses to the Oral Microbiome in Aging. / 2016 / PubMed / Full text
• Sperm-associated antigen 9 (SPAG9) promotes the survival and tumor growth of triple-negative breast cancer cells. / 10.2016 / PubMed / Full text
• Differential Matrix Metalloprotease (MMP) Expression Profiles Found in Aged Gingiva. / 2016 / PubMed / Full text
• Inflammageing assessed by MMP9 in normal Japanese individuals and the patients with Werner syndrome. / 05.2016 / PubMed / Full text
• Bone biology-related gingival transcriptome in ageing and periodontitis in non-human primates. / 05.2016 / PubMed / Full text
• The Nox1/4 Dual Inhibitor GKT137831 or Nox4 Knockdown Inhibits Angiotensin-II-Induced Adult Mouse Cardiac Fibroblast Proliferation and Migration. AT1 Physically Associates With Nox4. / 05.2016 / PubMed / Full text
• Defective autophagy in vascular smooth muscle cells accelerates senescence and promotes neointima formation and atherogenesis. / 02.11.2015 / PubMed / Full text
• Correlations between Photodegradation of Bisretinoid Constituents of Retina and Dicarbonyl Adduct Deposition. / 06.11.2015 / PubMed / Full text
• Fat and Sucrose Intake Induces Obesity-Related Bone Metabolism Disturbances: Kinetic and Reversibility Studies in Growing and Adult Rats. / 01.2016 / PubMed / Full text
• Endothelin-1 critically influences cardiac function via superoxide-MMP9 cascade. / 21.04.2015 / PubMed / Full text
• [The expression of differential and matrix remodelling factors in human buccal epithelium in aging]. / 2013 / PubMed
• A transcriptional roadmap to the senescence and differentiation of human oral keratinocytes. / 01.2015 / PubMed / Full text

TFEB

• A Novel Lipofuscin-detecting Marker of Senescence Relates With Hypoxia, Dysregulated Autophagy and With Poor Prognosis in Non-small-cell-lung Cancer. / 11-12.2020 / PubMed / Full text
• ESC-sEVs Rejuvenate Senescent Hippocampal NSCs by Activating Lysosomes to Improve Cognitive Dysfunction in Vascular Dementia. / 05.2020 / PubMed / Full text
• Nitrative Stress-Related Autophagic Insufficiency Participates in Hyperhomocysteinemia-Induced Renal Aging. / 2020 / PubMed / Full text
• Polyamines reverse immune senescence via the translational control of autophagy. / 01.2020 / PubMed / Full text
• Polyamines Control eIF5A Hypusination, TFEB Translation, and Autophagy to Reverse B Cell Senescence. / 03.10.2019 / PubMed / Full text
• Insulin-like peptides and the mTOR-TFEB pathway protect [i]Caenorhabditis elegans[/i] hermaphrodites from mating-induced death. / 08.07.2019 / PubMed / Full text
• Double knockout of Akt2 and AMPK predisposes cardiac aging without affecting lifespan: Role of autophagy and mitophagy. / 01.07.2019 / PubMed / Full text
• TFEB protects nucleus pulposus cells against apoptosis and senescence via restoring autophagic flux. / 02.2019 / PubMed / Full text
• Autophagy and mitophagy flux in young and aged skeletal muscle following chronic contractile activity. / 08.2018 / PubMed / Full text
• Nuclear Export Inhibition Enhances HLH-30/TFEB Activity, Autophagy, and Lifespan. / 15.05.2018 / PubMed / Full text
• Trans-Fats Inhibit Autophagy Induced by Saturated Fatty Acids. / 04.2018 / PubMed / Full text
• Small-molecule TFEB pathway agonists that ameliorate metabolic syndrome in mice and extend C. elegans lifespan. / 22.12.2017 / PubMed / Full text
• Peroxisomes contribute to oxidative stress in neurons during doxorubicin-based chemotherapy. / 01.2018 / PubMed / Full text
• TOR-mediated regulation of metabolism in aging. / 12.2017 / PubMed / Full text
• Nuclear AMPK regulated CARM1 stabilization impacts autophagy in aged heart. / 29.04.2017 / PubMed / Full text
• TFEB ameliorates the impairment of the autophagy-lysosome pathway in neurons induced by doxorubicin. / 16.12.2016 / PubMed / Full text
• Role of TFEB Mediated Autophagy, Oxidative Stress, Inflammation, and Cell Death in Endotoxin Induced Myocardial Toxicity of Young and Aged Mice. / 2016 / PubMed / Full text
• Critical role of lysosomes in the dysfunction of human Cardiac Stem Cells obtained from failing hearts. / 01.08.2016 / PubMed / Full text
• Mondo complexes regulate TFEB via TOR inhibition to promote longevity in response to gonadal signals. / 22.03.2016 / PubMed / Full text
• Transcriptional and epigenetic regulation of autophagy in aging. / 2015 / PubMed / Full text

ACE2

• How Does SARS-CoV-2 Affect the Central Nervous System? A Working Hypothesis. / 2020 / PubMed / Full text
• Bioinformatic characterization of angiotensin-converting enzyme 2, the entry receptor for SARS-CoV-2. / 2020 / PubMed / Full text
• A mouse-adapted model of SARS-CoV-2 to test COVID-19 countermeasures. / 10.2020 / PubMed / Full text
• COVID-19 and Senotherapeutics: Any Role for the Naturally-occurring Dipeptide Carnosine? / 07.2020 / PubMed / Full text
• The dual impact of ACE2 in COVID-19 and ironical actions in geriatrics and pediatrics with possible therapeutic solutions. / 15.09.2020 / PubMed / Full text
• The possible pathophysiology mechanism of cytokine storm in elderly adults with COVID-19 infection: the contribution of "inflame-aging". / 09.2020 / PubMed / Full text
• Decoding SARS-CoV-2 hijacking of host mitochondria in COVID-19 pathogenesis. / 01.08.2020 / PubMed / Full text
• A Mouse Model of SARS-CoV-2 Infection and Pathogenesis. / 08.07.2020 / PubMed / Full text
• COVID-19-associated cardiovascular morbidity in older adults: a position paper from the Italian Society of Cardiovascular Researches. / 08.2020 / PubMed / Full text
• Gut microbiota and Covid-19- possible link and implications. / 08.2020 / PubMed / Full text
• Inflamm-aging: Why older men are the most susceptible to SARS-CoV-2 complicated outcomes. / 06.2020 / PubMed / Full text
• Restoration of the Renin-Angiotensin System Balance Is a Part of the Effect of Fasting on Cardiovascular Rejuvenation: Role of Age and Fasting Models. / 08.2020 / PubMed / Full text
• Angiotensin 1-7 alleviates aging-associated muscle weakness and bone loss, but is not associated with accelerated aging in ACE2-knockout mice. / 30.09.2019 / PubMed / Full text
• Age-dependent differences in pulmonary host responses in ARDS: a prospective observational cohort study. / 14.05.2019 / PubMed / Full text
• The protective effect of resveratrol on vascular aging by modulation of the renin-angiotensin system. / 03.2018 / PubMed / Full text
• Sex differences in the aging pattern of renin-angiotensin system serum peptidases. / 2017 / PubMed / Full text
• Chymase-dependent production of angiotensin II: an old enzyme in old hearts. / 01.02.2017 / PubMed / Full text
• Age-Associated Changes in the Vascular Renin-Angiotensin System in Mice. / 2016 / PubMed / Full text
• Angiotensin converting enzyme 2/Ang-(1-7)/mas axis protects brain from ischemic injury with a tendency of age-dependence. / 05.2014 / PubMed / Full text

CFI

• Psychosocial Resources for Hedonic Balance, Life Satisfaction and Happiness in the Elderly: A Path Analysis. / 06.08.2020 / PubMed / Full text
• Validity and Reliability of the Flourishing Scale in a Sample of Older Adults in Iran. / 2020 / PubMed / Full text
• The decision about retirement: A scale to describe representations and practices of medical doctors and nurses. / 07-08.2016 / PubMed / Full text
• Family versus intimate partners: Estimating who matters more for health in a 20-year longitudinal study. / 03.2020 / PubMed / Full text
• Adapting and validating the Rosenberg Self-Esteem Scale for elderly Spanish population. / 02.2020 / PubMed / Full text
• Mediating Role of Fall-related Efficacy in a Fall Prevention Program. / 01.03.2019 / PubMed / Full text
• An application of Bayesian measurement invariance to modelling cognition over time in the English Longitudinal Study of Ageing. / 12.2018 / PubMed / Full text
• [New semantic-cultural validation and psychometric study of the CASP-19 scale in adult and elderly Brazilians]. / 11.10.2018 / PubMed / Full text
• Mental status evaluation in older adults with cancer: Development of the Mental Health Index-13. / 03.2019 / PubMed / Full text
• The ACTIVE conceptual framework as a structural equation model. / 01-02.2018 / PubMed / Full text
• The Utility of the Cognitive Function Instrument (CFI) to Detect Cognitive Decline in Non-Demented Older Adults. / 2017 / PubMed / Full text
• The effect of age on the response of retinal capillary filling to changes in intraocular pressure measured by optical coherence tomography angiography. / 01.2018 / PubMed / Full text
• Health, coping and subjective well-being: results of a longitudinal study of elderly Israelis. / 06.2017 / PubMed / Full text
• Women's intentions to use fertility preservation to prevent age-related fertility decline. / 01.2016 / PubMed / Full text
• Factorial Structure and Measurement Invariance of the PANAS in Spanish Older Adults. / 03.03.2015 / PubMed / Full text
• Assessing the factor structure of well-being in older adults: findings from the National Health and Aging Trends Study. / 08.2016 / PubMed / Full text
• Measuring frailty using self-report and test-based health measures. / 05.2015 / PubMed / Full text
• CASP-19 special section: how does chronic disease status affect CASP quality of life at older ages? Examining the WHO ICF disability domains as mediators of this relationship. / 07.2015 / PubMed / Full text
• Differential trajectories of well-being in older adult women: the role of optimism. / 11.2014 / PubMed / Full text

CLU

• Expression of Clusterin suppresses Cr(VI)-induced premature senescence through activation of PI3K/AKT pathway. / 15.11.2019 / PubMed / Full text
• Informative combination of CLU rs11136000, serum HDL levels, diabetes, and age as a new piece of puzzle-picture of predictive medicine for cognitive disorders. / 02.2019 / PubMed / Full text
• Integrative transcriptome analyses of the aging brain implicate altered splicing in Alzheimer's disease susceptibility. / 11.2018 / PubMed / Full text
• DNA methylation analysis on purified neurons and glia dissects age and Alzheimer's disease-specific changes in the human cortex. / 25.07.2018 / PubMed / Full text
• Recent studies on cellular and molecular mechanisms in Alzheimer's disease: focus on epigenetic factors and histone deacetylase. / 28.03.2018 / PubMed / Full text
• Role of CLU, PICALM, and TNK1 Genotypes in Aging With and Without Alzheimer's Disease. / 05.2018 / PubMed / Full text
• Late Onset Alzheimer's Disease Risk Variants in Cognitive Decline: The PATH Through Life Study. / 2017 / PubMed / Full text
• Association and interaction effects of Alzheimer's disease-associated genes and lifestyle on cognitive aging in older adults in a Taiwanese population. / 11.04.2017 / PubMed / Full text
• An Alzheimer's Disease Genetic Risk Score Predicts Longitudinal Thinning of Hippocampal Complex Subregions in Healthy Older Adults. / 05-06.2016 / PubMed / Full text
• Genetically-mediated Grey and White Matter Alteration in Normal Elderly Individuals with the CLU-C Allele Gene. / 2016 / PubMed / Full text
• Hippocampal proteomics defines pathways associated with memory decline and resilience in normal aging and Alzheimer's disease mouse models. / 30.03.2017 / PubMed / Full text
• Risk-reducing Apolipoprotein E and Clusterin genotypes protect against the consequences of poor vascular health on executive function performance and change in nondemented older adults. / 06.2016 / PubMed / Full text
• Impact of PICALM and CLU on hippocampal degeneration. / 07.2016 / PubMed / Full text
• Gene-based aggregate SNP associations between candidate AD genes and cognitive decline. / 04.2016 / PubMed / Full text
• Apolipoprotein E and Clusterin can magnify effects of personality vulnerability on declarative memory performance in non-demented older adults. / 05.2016 / PubMed / Full text
• Mesterolone treatment of aging male syndrome improves lower urinary tract symptoms. / 12.2014 / PubMed
• Combined effects of Alzheimer risk variants in the CLU and ApoE genes on ventricular expansion patterns in the elderly. / 07.05.2014 / PubMed / Full text
• The benefits of staying active in old age: physical activity counteracts the negative influence of PICALM, BIN1, and CLU risk alleles on episodic memory functioning. / 06.2014 / PubMed / Full text
• Age-dependent effect of Alzheimer's risk variant of CLU on EEG alpha rhythm in non-demented adults. / 2013 / PubMed / Full text

GDF15

• Disease-specific plasma levels of mitokines FGF21, GDF15, and Humanin in type II diabetes and Alzheimer's disease in comparison with healthy aging. / 31.10.2020 / PubMed / Full text
• Growth differentiation factor 15 protects against the aging-mediated systemic inflammatory response in humans and mice. / 08.2020 / PubMed / Full text
• Analysis of Epigenetic Age Predictors in Pain-Related Conditions. / 2020 / PubMed / Full text
• GDF15 Plasma Level Is Inversely Associated With Level of Physical Activity and Correlates With Markers of Inflammation and Muscle Weakness. / 2020 / PubMed / Full text
• GDF15 is an epithelial-derived biomarker of idiopathic pulmonary fibrosis. / 01.10.2019 / PubMed / Full text
• Senescence-associated tissue microenvironment promotes colon cancer formation through the secretory factor GDF15. / 12.2019 / PubMed / Full text
• mTORC1 underlies age-related muscle fiber damage and loss by inducing oxidative stress and catabolism. / 06.2019 / PubMed / Full text
• Expression of lipogenic markers is decreased in subcutaneous adipose tissue and adipocytes of older women and is negatively linked to GDF15 expression. / 08.2019 / PubMed / Full text
• Growth differentiation factor 15 (GDF15): A survival protein with therapeutic potential in metabolic diseases. / 06.2019 / PubMed / Full text
• [The role of «Youth and aging proteins» in essential hypertension pathogenesis.] / 2018 / PubMed
• A framework for selection of blood-based biomarkers for geroscience-guided clinical trials: report from the TAME Biomarkers Workgroup. / 12.2018 / PubMed / Full text
• Towards frailty biomarkers: Candidates from genes and pathways regulated in aging and age-related diseases. / 11.2018 / PubMed / Full text
• Plasma proteomic signature of age in healthy humans. / 10.2018 / PubMed / Full text
• Human Aging and Longevity Are Characterized by High Levels of Mitokines. / 23.04.2019 / PubMed / Full text
• Induction of Growth Differentiation Factor 15 in Skeletal Muscle of Old Taurine Transporter Knockout Mouse. / 2018 / PubMed / Full text
• Cigarette Smoke Induces Human Airway Epithelial Senescence via Growth Differentiation Factor 15 Production. / 09.2016 / PubMed / Full text
• Secreted growth differentiation factor 15 as a potential biomarker for mitochondrial dysfunctions in aging and age-related disorders. / 03.2016 / PubMed / Full text
• GDF15 contributes to radiation-induced senescence through the ROS-mediated p16 pathway in human endothelial cells. / 01.03.2016 / PubMed / Full text
• hNAG-1 increases lifespan by regulating energy metabolism and insulin/IGF-1/mTOR signaling. / 08.2014 / PubMed / Full text

MCC

• Multiple chronic conditions and risk of cognitive impairment and dementia among older Americans: findings from the Aging, Demographics, and Memory Study (ADAMS). / 07.07.2020 / PubMed / Full text
• Behaviour consistency is a sensitive tool for distinguishing the effects of aging on physical activity. / 01.07.2020 / PubMed / Full text
• Burden on Caregivers of Adults with Multiple Chronic Conditions: Intersectionality of Age, Gender, Education level, Employment Status, and Impact on Social Life. / 09.2020 / PubMed / Full text
• Using the Technology Acceptance Model to Explore User Experience, Intent to Use, and Use Behavior of a Patient Portal Among Older Adults With Multiple Chronic Conditions: Descriptive Qualitative Study. / 08.04.2019 / PubMed / Full text
• Trends in Risk of Limitations in Instrumental Activities of Daily Living Over Age in Older Persons With and Without Multiple Chronic Conditions. / 01.01.2020 / PubMed / Full text
• Association between treatment of superficial bladder cancer and 10-year mortality in older adults with multiple chronic conditions. / 01.12.2018 / PubMed / Full text
• The AGING Initiative experience: a call for sustained support for team science networks. / 18.05.2018 / PubMed / Full text
• Evidence on selection, optimization, and compensation strategies to optimize aging with multiple chronic conditions: A literature review. / 09-10.2018 / PubMed / Full text
• Chronic disease burden predicts food insecurity among older adults. / 06.2018 / PubMed / Full text
• Differences Between Younger and Older US Adults With Multiple Chronic Conditions. / 07.09.2017 / PubMed / Full text
• Prevalence, Correlates, and Time Trends of Multiple Chronic Conditions Among Israeli Adults: Estimates From the Israeli National Health Interview Survey, 2014-2015. / 10.08.2017 / PubMed / Full text
• Seed incorporation during vinification and its impact on chemical and organoleptic properties in Syzygium cumini wine. / 15.12.2017 / PubMed / Full text
• Research Priorities to Advance the Health and Health Care of Older Adults with Multiple Chronic Conditions. / 07.2017 / PubMed / Full text
• The ACHRU-CPP versus usual care for older adults with type-2 diabetes and multiple chronic conditions and their family caregivers: study protocol for a randomized controlled trial. / 06.02.2017 / PubMed / Full text
• Changes in Depressive Symptoms among Older Adults with Multiple Chronic Conditions: Role of Positive and Negative Social Support. / 26.12.2016 / PubMed / Full text
• Sex-specific effects of cytotoxic chemotherapy agents cyclophosphamide and mitomycin C on gene expression, oxidative DNA damage, and epigenetic alterations in the prefrontal cortex and hippocampus - an aging connection. / 04.2016 / PubMed / Full text
• Reduced mucociliary clearance in old mice is associated with a decrease in Muc5b mucin. / 01.05.2016 / PubMed / Full text
• Corrupt practices negatively influenced food security and live expectancy in developing countries. / 2015 / PubMed / Full text
• Decision-making and cancer screening: a qualitative study of older adults with multiple chronic conditions. / 03.2015 / PubMed / Full text

MMP2

• Cellular retinoic acid binding protein-II expression and its potential role in skin aging. / 18.03.2019 / PubMed / Full text
• [Effect of saponins extracted from Panax japonicas on inhibiting myocardial fibrosis by TGF-β1/Smad3 signaling pathway in aging rats]. / 11.2018 / PubMed / Full text
• TMT-Based Quantitative Proteomic Analysis Reveals Proteomic Changes Involved in Longevity. / 07.2019 / PubMed / Full text
• MicroRNA-338-5p plays a tumor suppressor role in glioma through inhibition of the MAPK-signaling pathway by binding to FOXD1. / 12.2018 / PubMed / Full text
• PM2.5 promotes abdominal aortic aneurysm formation in angiotensin Ⅱ-infused apoe-/- mice. / 08.2018 / PubMed / Full text
• Activation of DNA demethylases attenuates aging-associated arterial stiffening and hypertension. / 08.2018 / PubMed / Full text
• MMP2-A2M interaction increases ECM accumulation in aged rat kidney and its modulation by calorie restriction. / 19.01.2018 / PubMed / Full text
• Systemic analysis of gene expression profiles in porcine granulosa cells during aging. / 14.11.2017 / PubMed / Full text
• Timing and duration of nursing from birth affect neonatal porcine uterine matrix metalloproteinase 9 and tissue inhibitor of metalloproteinase 1. / 04.2017 / PubMed / Full text
• Secondhand Smoke Exposure Enhances Cardiac Fibrosis Effects on the Aging Rat Hearts. / 09.2016 / PubMed / Full text
• Sperm-associated antigen 9 (SPAG9) promotes the survival and tumor growth of triple-negative breast cancer cells. / 10.2016 / PubMed / Full text
• Stimulation of cellular senescent processes, including secretory phenotypes and anti-oxidant responses, after androgen deprivation therapy in human prostate cancer. / 01.2017 / PubMed / Full text
• Unbiased analysis of senescence associated secretory phenotype (SASP) to identify common components following different genotoxic stresses. / 07.2016 / PubMed / Full text
• Synaptic roles for phosphomannomutase type 2 in a new Drosophila congenital disorder of glycosylation disease model. / 01.05.2016 / PubMed / Full text
• Correlations between Photodegradation of Bisretinoid Constituents of Retina and Dicarbonyl Adduct Deposition. / 06.11.2015 / PubMed / Full text
• Fat and Sucrose Intake Induces Obesity-Related Bone Metabolism Disturbances: Kinetic and Reversibility Studies in Growing and Adult Rats. / 01.2016 / PubMed / Full text
• Differential levels of cathepsin B and L in serum between young and aged healthy people and their association with matrix metalloproteinase 2. / 09-10.2015 / PubMed / Full text
• [The expression of differential and matrix remodelling factors in human buccal epithelium in aging]. / 2013 / PubMed
• Metzincins and related genes in experimental renal ageing: towards a unifying fibrosis classifier across species. / 06.2014 / PubMed / Full text

NAMPT

• Over-expression of Nicotinamide phosphoribosyltransferase in mouse cells confers protective effect against oxidative and ER stress-induced premature senescence. / 08.2020 / PubMed / Full text
• Resistance training increases muscle NAD and NADH concentrations as well as NAMPT protein levels and global sirtuin activity in middle-aged, overweight, untrained individuals. / 05.05.2020 / PubMed / Full text
• Differential Expression of Human N-Alpha-Acetyltransferase 40 (hNAA40), Nicotinamide Phosphoribosyltransferase (NAMPT) and Sirtuin-1 (SIRT-1) Pathway in Obesity and T2DM: Modulation by Metformin and Macronutrient Intake. / 2019 / PubMed / Full text
• Aerobic and resistance exercise training reverses age-dependent decline in NAD salvage capacity in human skeletal muscle. / 07.2019 / PubMed / Full text
• Extracellular Vesicle-Contained eNAMPT Delays Aging and Extends Lifespan in Mice. / 06.08.2019 / PubMed / Full text
• lncRNA GAS5/miR-223/NAMPT axis modulates the cell proliferation and senescence of endothelial progenitor cells through PI3K/AKT signaling. / 09.2019 / PubMed / Full text
• Aged Nicotinamide Riboside Kinase 2 Deficient Mice Present an Altered Response to Endurance Exercise Training. / 2018 / PubMed / Full text
• Loss of NAMPT in aging retinal pigment epithelium reduces NAD availability and promotes cellular senescence. / 12.06.2018 / PubMed / Full text
• Nicotinamide phosphoribosyltransferase delays cellular senescence by upregulating SIRT1 activity and antioxidant gene expression in mouse cells. / 12.2017 / PubMed / Full text
• Deletion of Nampt in Projection Neurons of Adult Mice Leads to Motor Dysfunction, Neurodegeneration, and Death. / 29.08.2017 / PubMed / Full text
• Nicotinamide Phosphoribosyltransferase in Smooth Muscle Cells Maintains Genome Integrity, Resists Aortic Medial Degeneration, and Is Suppressed in Human Thoracic Aortic Aneurysm Disease. / 09.06.2017 / PubMed / Full text
• Effect of lifelong football training on the expression of muscle molecular markers involved in healthy longevity. / 04.2017 / PubMed / Full text
• Aging and caloric restriction impact adipose tissue, adiponectin, and circulating lipids. / 06.2017 / PubMed / Full text
• Autophagic homeostasis is required for the pluripotency of cancer stem cells. / 02.2017 / PubMed / Full text
• NAMPT regulates senescence, proliferation, and migration of endothelial progenitor cells through the SIRT1 AS lncRNA/miR-22/SIRT1 pathway. / 23.09.2016 / PubMed / Full text
• Hepatic NAD( ) deficiency as a therapeutic target for non-alcoholic fatty liver disease in ageing. / 08.2016 / PubMed / Full text
• Targeting Nicotinamide Phosphoribosyltransferase as a Potential Therapeutic Strategy to Restore Adult Neurogenesis. / 06.2016 / PubMed / Full text
• A critical role of nicotinamide phosphoribosyltransferase in human telomerase reverse transcriptase induction by resveratrol in aortic smooth muscle cells. / 10.05.2015 / PubMed / Full text
• Relative importance of redox buffers GSH and NAD(P)H in age-related neurodegeneration and Alzheimer disease-like mouse neurons. / 08.2014 / PubMed / Full text

SST

• The distance to death perceptions of older adults explain why they age in place: A theoretical examination. / 09.2020 / PubMed / Full text
• Population Segmentation Based on Healthcare Needs: Validation of a Brief Clinician-Administered Tool. / 30.06.2020 / PubMed / Full text
• Examination on how emotion regulation mediates the relationship between future time perspective and well-being: a counter-evidence to the socioemotional selectivity theory. / 03.2020 / PubMed / Full text
• Shear-Wave and Strain Ultrasound Elastography of the Supraspinatus and Infraspinatus Tendons in Patients with Idiopathic Adhesive Capsulitis of the Shoulder: A Prospective Case-Control Study. / 07.2019 / PubMed / Full text
• Counting down while time flies: implications of age-related time acceleration for goal pursuit across adulthood. / 04.2019 / PubMed / Full text
• Relative costs and benefits of alternative reproductive phenotypes at different temperatures - genotype-by-environment interactions in a sexually selected trait. / 11.07.2018 / PubMed / Full text
• Climate change and functional traits affect population dynamics of a long-lived seabird. / 07.2018 / PubMed / Full text
• Influence of season, age and management on scrotal thermal profile in Murrah bulls using scrotal infrared digital thermography. / 12.2017 / PubMed / Full text
• The roles of chronological age and time perspective in memory positivity. / 07.2018 / PubMed / Full text
• Atypical Red Blood Cells Are Prevalent in California Sea Lion Pups Born during Anomalous Sea Surface Temperature Events. / 09-10.2017 / PubMed / Full text
• DNA methylation-based age prediction from saliva: High age predictability by combination of 7 CpG markers. / 07.2017 / PubMed / Full text
• Sleep/wake movement velocities, trajectories and micro-arousals during maturation in rats. / 07.02.2017 / PubMed / Full text
• When meaning matters more: Media preferences across the adult life span. / 08.2016 / PubMed / Full text
• An improved spatial span test of visuospatial memory. / 09.2016 / PubMed / Full text
• Hypermethylation of BDNF and SST Genes in the Orbital Frontal Cortex of Older Individuals: A Putative Mechanism for Declining Gene Expression with Age. / 10.2015 / PubMed / Full text
• Sleep/Wake Dynamics Changes during Maturation in Rats. / 2015 / PubMed / Full text
• Sleep disturbance associated with rotator cuff tear: correction with arthroscopic rotator cuff repair. / 06.2015 / PubMed / Full text
• A cortical disinhibitory circuit for enhancing adult plasticity. / 27.01.2015 / PubMed / Full text
• Telemetry and random-walk models reveal complex patterns of partial migration in a large marine predator. / 11.2013 / PubMed / Full text

UCP1

• Muscle-dependent regulation of adipose tissue function in long-lived growth hormone-mutant mice. / 28.05.2020 / PubMed / Full text
• Lack of UCP1 stimulates fatty liver but mediates UCP1-independent action of beige fat to improve hyperlipidemia in Apoe knockout mice. / 01.07.2020 / PubMed / Full text
• Postnatal leptin surge is critical for the transient induction of the developmental beige adipocytes in mice. / 01.04.2020 / PubMed / Full text
• Age-related sex differences in the expression of important disease-linked mitochondrial proteins in mice. / 05.12.2019 / PubMed / Full text
• An anti-inflammatory phenotype in visceral adipose tissue of old lean mice, augmented by exercise. / 19.08.2019 / PubMed / Full text
• Brown and Beige Adipose Tissue and Aging. / 2019 / PubMed / Full text
• Resveratrol and HIV-protease inhibitors control UCP1 expression through opposite effects on p38 MAPK phosphorylation in human adipocytes. / 02.2020 / PubMed / Full text
• Circulating factors present in the sera of naturally skinny people may influence cell commitment and adipocyte differentiation of mesenchymal stromal cells. / 26.03.2019 / PubMed / Full text
• Assessment of the Aging of the Brown Adipose Tissue by F-FDG PET/CT Imaging in the Progeria Mouse Model Lmna . / 2018 / PubMed / Full text
• Inactivation of the E3 Ubiquitin Ligase IDOL Attenuates Diet-Induced Obesity and Metabolic Dysfunction in Mice. / 08.2018 / PubMed / Full text
• Rapamycin Reverses Metabolic Deficits in Lamin A/C-Deficient Mice. / 06.12.2016 / PubMed / Full text
• Targeted mitochondrial uncoupling beyond UCP1 - The fine line between death and metabolic health. / 03.2017 / PubMed / Full text
• Methionine restriction improves renal insulin signalling in aged kidneys. / 07.2016 / PubMed / Full text
• Age-related changes of serum mitochondrial uncoupling 1, rumen and rectal temperature in goats. / 07.2016 / PubMed / Full text
• Sestrin2, a Regulator of Thermogenesis and Mitohormesis in Brown Adipose Tissue. / 2015 / PubMed / Full text
• [The role of uncoupling proteins in mechanisms of protection from oxidative stress]. / 2015 / PubMed / Full text
• Miglitol protects against age-dependent weight gain in mice: A potential role of increased UCP1 content in brown adipose tissue. / 2015 / PubMed / Full text
• Shc depletion stimulates brown fat activity in vivo and in vitro. / 12.2014 / PubMed / Full text
• Inducible brown adipocytes in subcutaneous inguinal white fat: the role of continuous sympathetic stimulation. / 01.11.2014 / PubMed / Full text

CDKN1A

• Involvement of CDKN1A (p21) in cellular senescence in response to heat and irradiation stress during preimplantation development. / 05.2020 / PubMed / Full text
• Chromatin remodeling factor BAZ1A regulates cellular senescence in both cancer and normal cells. / 15.07.2019 / PubMed / Full text
• Histone demethylase KDM6B regulates 1,25-dihydroxyvitamin D3-induced senescence in glioma cells. / 08.2019 / PubMed / Full text
• A Novel [i]Dnmt3a1[/i] Transcript Inhibits Adipogenesis. / 2018 / PubMed / Full text
• Altered modulation of lamin A/C-HDAC2 interaction and p21 expression during oxidative stress response in HGPS. / 10.2018 / PubMed / Full text
• Conditioned medium from stimulated macrophages inhibits growth but induces an inflammatory phenotype in breast cancer cells. / 10.2018 / PubMed / Full text
• DNA damage and neurodegenerative phenotypes in aged Ciz1 null mice. / 02.2018 / PubMed / Full text
• Cellular Senescence in Mouse Hippocampus After Irradiation and the Role of p53 and p21. / 01.04.2017 / PubMed / Full text
• p16 enhances the transcriptional and the apoptotic functions of p53 through DNA-dependent interaction. / 07.2017 / PubMed / Full text
• Establishment and application of a novel patient-derived KIAA1549:BRAF-driven pediatric pilocytic astrocytoma model for preclinical drug testing. / 14.02.2017 / PubMed / Full text
• Phosphorylation of MITF by AKT affects its downstream targets and causes TP53-dependent cell senescence. / 11.2016 / PubMed / Full text
• Induction of DNA double-strand breaks and cellular senescence by human respiratory syncytial virus. / 18.05.2016 / PubMed / Full text
• Docosahexaenoic acid prevented tumor necrosis factor alpha-induced endothelial dysfunction and senescence. / 01.2016 / PubMed / Full text
• TP53inp1 Gene Is Implicated in Early Radiation Response in Human Fibroblast Cells. / 23.10.2015 / PubMed / Full text
• Genomic regulation of senescence and innate immunity signaling in the retinal pigment epithelium. / 06.2015 / PubMed / Full text
• Tocotrienol-rich fraction prevents cellular aging by modulating cell proliferation signaling pathways. / 2015 / PubMed / Full text
• Orphan nuclear receptor TLX functions as a potent suppressor of oncogene-induced senescence in prostate cancer via its transcriptional co-regulation of the CDKN1A (p21(WAF1) (/) (CIP1) ) and SIRT1 genes. / 05.2015 / PubMed / Full text
• Gene polymorphisms of cellular senescence marker p21 and disease progression in non-alcohol-related fatty liver disease. / 2014 / PubMed / Full text

DNMT1

• DNA Methyltransferase 1 (DNMT1) Function Is Implicated in the Age-Related Loss of Cortical Interneurons. / 2020 / PubMed / Full text
• Age-related Changes in the Global DNA Methylation Profile of Oligodendrocyte Progenitor Cells Derived from Rat Spinal Cords. / 02.2019 / PubMed / Full text
• Epigallocatechin-3-gallate and BIX-01294 have different impact on epigenetics and senescence modulation in acute and chronic myeloid leukemia cells. / 05.11.2018 / PubMed / Full text
• Resveratrol promotes oxidative stress to drive DLC1 mediated cellular senescence in cancer cells. / 15.09.2018 / PubMed / Full text
• Ultraviolet A irradiation induces senescence in human dermal fibroblasts by down-regulating DNMT1 via ZEB1. / 16.02.2018 / PubMed / Full text
• Microrna-217 modulates human skin fibroblast senescence by directly targeting DNA methyltransferase 1. / 16.05.2017 / PubMed / Full text
• A positive feedback loop between Pim-1 kinase and HBP1 transcription factor contributes to hydrogen peroxide-induced premature senescence and apoptosis. / 19.05.2017 / PubMed / Full text
• miR-377 induces senescence in human skin fibroblasts by targeting DNA methyltransferase 1. / 09.03.2017 / PubMed / Full text
• Converting Adult Pancreatic Islet α Cells into β Cells by Targeting Both Dnmt1 and Arx. / 07.03.2017 / PubMed / Full text
• The Ubiquitin-like with PHD and Ring Finger Domains 1 (UHRF1)/DNA Methyltransferase 1 (DNMT1) Axis Is a Primary Regulator of Cell Senescence. / 03.03.2017 / PubMed / Full text
• Short term methionine restriction increases hepatic global DNA methylation in adult but not young male C57BL/6J mice. / 02.2017 / PubMed / Full text
• In vivo and in silico studies to identify mechanisms associated with Nurr1 modulation following early life exposure to permethrin in rats. / 06.01.2017 / PubMed / Full text
• Age-Related Changes in DNA Methylation Associated with Shifting Th1/Th2 Balance. / 12.2016 / PubMed / Full text
• CDK4-CDK6 inhibitors induce autophagy-mediated degradation of DNMT1 and facilitate the senescence antitumor response. / 02.10.2016 / PubMed / Full text
• Developmental lead exposure and lifespan alterations in epigenetic regulators and their correspondence to biomarkers of Alzheimer's disease. / 2016 / PubMed / Full text
• Age-dependent expression of DNMT1 and DNMT3B in PBMCs from a large European population enrolled in the MARK-AGE study. / 08.2016 / PubMed / Full text
• SIRT1 affects DNA methylation of polycomb group protein target genes, a hotspot of the epigenetic shift observed in ageing. / 24.06.2015 / PubMed / Full text
• The Interplay Between miR-148a and DNMT1 Might be Exploited for Pancreatic Cancer Therapy. / 2015 / PubMed / Full text

DNMT3A

• Epigenetic regulation of miR-29a/miR-30c/DNMT3A axis controls SOD2 and mitochondrial oxidative stress in human mesenchymal stem cells. / 09.09.2020 / PubMed / Full text
• Collagens and DNA methyltransferases in mare endometrosis. / 09.2019 / PubMed / Full text
• Age-related clonal haemopoiesis is associated with increased epigenetic age. / 19.08.2019 / PubMed / Full text
• Alcohol Extracts From [i]Ganoderma lucidum[/i] Delay the Progress of Alzheimer's Disease by Regulating DNA Methylation in Rodents. / 2019 / PubMed / Full text
• Targeted, Amplicon-Based, Next-Generation Sequencing to Detect Age-Related Clonal Hematopoiesis. / 2019 / PubMed / Full text
• Clonal hematopoiesis: Genes and underlying mechanisms in cardiovascular disease development. / 06.2019 / PubMed / Full text
• Concise Review: Age-Related Clonal Hematopoiesis: Stem Cells Tempting the Devil. / 09.2018 / PubMed / Full text
• Effects of Parental Aging During Embryo Development and Adult Life: The Case of Nothobranchius furzeri. / 04.2018 / PubMed / Full text
• Genetic Biomarkers on Age-Related Cognitive Decline. / 2017 / PubMed / Full text
• An inflammatory environment containing TNFα favors Tet2-mutant clonal hematopoiesis. / 03.2018 / PubMed / Full text
• Sequential acquisition of mutations in myelodysplastic syndromes. / 2017 / PubMed / Full text
• How stable is repression of disallowed genes in pancreatic islets in response to metabolic stress? / 2017 / PubMed / Full text
• miR-194 functions as a novel modulator of cellular senescence in mouse embryonic fibroblasts. / 03.2017 / PubMed / Full text
• A primer for epigenetics of hematological malignancies. / 2016 / PubMed / Full text
• Methylation of LOXL1 Promoter by DNMT3A in Aged Human Skin Fibroblasts. / 04.2017 / PubMed / Full text
• Insight into the molecular pathophysiology of myelodysplastic syndromes: targets for novel therapy. / 10.2016 / PubMed / Full text
• No association of the variant rs11887120 in DNMT3A with cognitive decline in individuals with mild cognitive impairment. / 05.2016 / PubMed / Full text
• DNMT3A moderates cognitive decline in subjects with mild cognitive impairment: replicated evidence from two mild cognitive impairment cohorts. / 2015 / PubMed / Full text

E2F1

• Regulation of E2F1 activity via PKA-mediated phosphorylations. / 2020 / PubMed / Full text
• Astragaloside IV ameliorates radiation-induced senescence via antioxidative mechanism. / 08.2020 / PubMed / Full text
• E2F1 mediates the downregulation of POLD1 in replicative senescence. / 07.2019 / PubMed / Full text
• Low dose Emodin induces tumor senescence for boosting breast cancer chemotherapy via silencing NRARP. / 10.11.2018 / PubMed / Full text
• Downregulation of FOXP1 correlates with tendon stem/progenitor cells aging. / 26.09.2018 / PubMed / Full text
• Loss of circadian protein TIMELESS accelerates the progression of cellular senescence. / 18.09.2018 / PubMed / Full text
• Transcriptional Repression of High-Mobility Group Box 2 by p21 in Radiation-Induced Senescence. / 30.04.2018 / PubMed / Full text
• Genome-wide association study and annotating candidate gene networks affecting age at first calving in Nellore cattle. / 12.2017 / PubMed / Full text
• Triptolide Promotes Senescence of Prostate Cancer Cells Through Histone Methylation and Heterochromatin Formation / 27.09.2017 / PubMed / Full text
• Senescence-associated microRNAs target cell cycle regulatory genes in normal human lung fibroblasts. / 01.10.2017 / PubMed / Full text
• Neuronal tetraploidization in the cerebral cortex correlates with reduced cognition in mice and precedes and recapitulates Alzheimer's-associated neuropathology. / 08.2017 / PubMed / Full text
• Old age and the associated impairment of bones' adaptation to loading are associated with transcriptomic changes in cellular metabolism, cell-matrix interactions and the cell cycle. / 30.01.2017 / PubMed / Full text
• Rac1-Mediated DNA Damage and Inflammation Promote Nf2 Tumorigenesis but Also Limit Cell-Cycle Progression. / 21.11.2016 / PubMed / Full text
• The activation of OR51E1 causes growth suppression of human prostate cancer cells. / 26.07.2016 / PubMed / Full text
• Foxo3 circular RNA promotes cardiac senescence by modulating multiple factors associated with stress and senescence responses. / 07.05.2017 / PubMed / Full text
• CBX8 antagonizes the effect of Sirtinol on premature senescence through the AKT-RB-E2F1 pathway in K562 leukemia cells. / 22.01.2016 / PubMed / Full text
• Nucleolar repression facilitates initiation and maintenance of senescence. / 2015 / PubMed / Full text
• Targeted gene mutation of E2F1 evokes age-dependent synaptic disruption and behavioral deficits. / 06.2014 / PubMed / Full text

EPO

• Regulation of muscle and metabolic physiology by hypothalamic erythropoietin independently of its peripheral action. / 02.2020 / PubMed / Full text
• Red Blood Cell Lifespan Shortening in Patients with Early-Stage Chronic Kidney Disease. / 2019 / PubMed / Full text
• Age-Dependent Systemic Effects of a Systemic Intermittent Hypoxic Therapy [i]In Vivo[/i]. / 09.2019 / PubMed / Full text
• Erythropoietin does not improve fracture healing in aged mice. / 15.07.2019 / PubMed / Full text
• Dose-response relationship of intermittent normobaric hypoxia to stimulate erythropoietin in the context of health promotion in young and old people. / 05.2019 / PubMed / Full text
• rhEPO Enhances Cellular Anti-oxidant Capacity to Protect Long-Term Cultured Aging Primary Nerve Cells. / 08.2017 / PubMed / Full text
• [Effects of recombinant human erythropoietin on brain-derived neurotrophic factor expression in different brain regions of aging rats]. / 20.04.2016 / PubMed / Full text
• Warming Up to New Possibilities with the Capsaicin Receptor TRPV1: mTOR, AMPK, and Erythropoietin. / 2017 / PubMed / Full text
• The Anti-Aging Effect of Erythropoietin via the ERK/Nrf2-ARE Pathway in Aging Rats. / 03.2017 / PubMed / Full text
• Age-associated expression of erythropoietin and its receptor in rat spiral ganglion neurons and its association with neuronal apoptosis and hearing alterations. / 01.2017 / PubMed / Full text
• Erythropoietin and mTOR: A "One-Two Punch" for Aging-Related Disorders Accompanied by Enhanced Life Expectancy. / 2016 / PubMed / Full text
• Erythropoietin Does Not Enhance Skeletal Muscle Protein Synthesis Following Exercise in Young and Older Adults. / 2016 / PubMed / Full text
• Oxidative stress induces the decline of brain EPO expression in aging rats. / 10.2016 / PubMed / Full text
• Sub-acute systemic erythropoietin administration reduces ischemic brain injury in an age-dependent manner. / 14.06.2016 / PubMed / Full text
• Erythropoietin Attenuates the Memory Deficits in Aging Rats by Rescuing the Oxidative Stress and Inflammation and Promoting BDNF Releasing. / 10.2016 / PubMed / Full text
• rhEPO affects apoptosis in hippocampus of aging rats by upregulating SIRT1. / 2015 / PubMed / Full text
• Coated dextrin microcapsules of amlodipine incorporable into orally disintegrating tablets for geriatric patients. / 10.2014 / PubMed / Full text
• Neocytolysis: none, one or many? A reappraisal and future perspectives. / 2014 / PubMed / Full text

GAL

• Overexpression of Pitx1 attenuates the senescence of chondrocytes from osteoarthritis degeneration cartilage-A self-controlled model for studying the etiology and treatment of osteoarthritis. / 02.2020 / PubMed / Full text
• β-Caryophyllene Reduces DNA Oxidation and the Overexpression of Glial Fibrillary Acidic Protein in the Prefrontal Cortex and Hippocampus of d-Galactose-Induced Aged BALB/c Mice. / 05.2020 / PubMed / Full text
• Senescence-associated β-galactosidase activity in the developing avian retina. / 09.2019 / PubMed / Full text
• Zeaxanthin Isolated from [i]Dunaliella salina[/i] Microalgae Ameliorates Age Associated Cardiac Dysfunction in Rats through Stimulation of Retinoid Receptors. / 14.05.2019 / PubMed / Full text
• Effects of sulforaphane on D-galactose-induced liver aging in rats: Role of keap-1/nrf-2 pathway. / 15.07.2019 / PubMed / Full text
• MYC and RAS are unable to cooperate in overcoming cellular senescence and apoptosis in normal human fibroblasts. / 2018 / PubMed / Full text
• Manipulation of molecular pathways and senescence hallmarks by natural compounds in fibroblast cells. / 04.2019 / PubMed / Full text
• Ellagic acid reveals promising anti-aging effects against d-galactose-induced aging on human neuroblastoma cell line, SH-SY5Y: A mechanistic study. / 12.2018 / PubMed / Full text
• Molecular and biochemical evidence on the protective role of ellagic acid and silybin against oxidative stress-induced cellular aging. / 04.2018 / PubMed / Full text
• Hyperphosphatemia induces senescence in human endothelial cells by increasing endothelin-1 production. / 12.2017 / PubMed / Full text
• Carnosine Treatment Diminished Oxidative Stress and Glycation Products in Serum and Tissues of D-Galactose-Treated Rats. / 2018 / PubMed / Full text
• Oncogene-Induced Senescence in Pituitary Adenomas--an Immunohistochemical Study. / 03.2016 / PubMed / Full text
• Carnosine and taurine treatments diminished brain oxidative stress and apoptosis in D-galactose aging model. / 04.2016 / PubMed / Full text
• The role of TORC1 in muscle development in Drosophila. / 13.04.2015 / PubMed / Full text
• N-ethyl-N-Nitrosourea (ENU) induced mutations within the klotho gene lead to ectopic calcification and reduced lifespan in mouse models. / 2015 / PubMed / Full text
• Five years of interdisciplinary research on ageing and technology: Outcomes of the Lower Saxony Research Network Design of Environments for Ageing (GAL)--an introduction to this Special Issue on Ageing and Technology. / 09-12.2014 / PubMed / Full text
• Information and communication technologies for promoting and sustaining quality of life, health and self-sufficiency in ageing societies--outcomes of the Lower Saxony Research Network Design of Environments for Ageing (GAL). / 09-12.2014 / PubMed / Full text
• Cyanidin-3-O-galactoside and blueberry extracts supplementation improves spatial memory and regulates hippocampal ERK expression in senescence-accelerated mice. / 03.2014 / PubMed / Full text

NQO1

• Augmentation of cellular NAD by NQO1 enzymatic action improves age-related hearing impairment. / 10.2019 / PubMed / Full text
• Well-aging: A new strategy for skin homeostasis under multi-stressed conditions. / 02.2020 / PubMed / Full text
• Limitations to adaptive homeostasis in an hyperoxia-induced model of accelerated ageing. / 06.2019 / PubMed / Full text
• Link between cardiac function and the antioxidative defense mechanism in aged rats. / 11.06.2019 / PubMed / Full text
• [Protective effect of Wuzi Yanzong recipe on testicular DNA oxidative damage in natural ageing rats]. / 07.2018 / PubMed / Full text
• Benefits of Caloric Restriction in Longevity and Chemical-Induced Tumorigenesis Are Transmitted Independent of NQO1. / 16.01.2019 / PubMed / Full text
• Overexpression of CYB5R3 and NQO1, two NAD -producing enzymes, mimics aspects of caloric restriction. / 08.2018 / PubMed / Full text
• Sargassum fusiforme Polysaccharide Rejuvenat es the Small Intestine in Mice Through Altering its Physiol ogy and Gut Microbiota Composition. / 2017 / PubMed / Full text
• Apigenin exhibits protective effects in a mouse model of d-galactose-induced aging via activating the Nrf2 pathway. / 21.06.2017 / PubMed / Full text
• The ontogeny and population variability of human hepatic dihydronicotinamide riboside:quinone oxidoreductase (NQO2). / 08.2017 / PubMed / Full text
• Gardenia jasminoides extract-capped gold nanoparticles reverse hydrogen peroxide-induced premature senescence. / 11.2016 / PubMed / Full text
• Stimulation of cellular senescent processes, including secretory phenotypes and anti-oxidant responses, after androgen deprivation therapy in human prostate cancer. / 01.2017 / PubMed / Full text
• Exercise-induced Nrf2-signaling is impaired in aging. / 07.2016 / PubMed / Full text
• Abrogation of Nrf2 impairs antioxidant signaling and promotes atrial hypertrophy in response to high-intensity exercise stress. / 05.04.2016 / PubMed / Full text
• The Ontogeny and Population Variability of Human Hepatic NADPH Dehydrogenase Quinone Oxido-Reductase 1 (NQO1). / 07.2016 / PubMed / Full text
• Acetaminophen hepatotoxicity in mice: Effect of age, frailty and exposure type. / 01.2016 / PubMed / Full text
• NQO1 Stabilizes p53 in Response to Oncogene-Induced Senescence. / 2015 / PubMed / Full text
• Neophobia, NQO1 and SIRT1 as premorbid and prodromal indicators of AD in 3xTg-AD mice. / 01.09.2014 / PubMed / Full text

TREM2

• Loss of TREM2 Confers Resilience to Synaptic and Cognitive Impairment in Aged Mice. / 09.12.2020 / PubMed / Full text
• Triggering Receptor Expressed on Myeloid Cell 2 R47H Exacerbates Immune Response in Alzheimer's Disease Brain. / 2020 / PubMed / Full text
• Knockdown of astrocytic TREM2 in the hippocampus relieves cognitive decline in elderly male mice. / 15.01.2021 / PubMed / Full text
• Immune Signaling in Neurodegeneration. / 16.04.2019 / PubMed / Full text
• The Triggering Receptor Expressed on Myeloid Cells-2 (TREM-2) as Expression of the Relationship between Microglia and Alzheimer's Disease: A Novel Marker for a Promising Pathway to Explore. / 2019 / PubMed / Full text
• TREM2 triggers microglial density and age-related neuronal loss. / 03.2019 / PubMed / Full text
• Differential effects of partial and complete loss of TREM2 on microglial injury response and tauopathy. / 02.10.2018 / PubMed / Full text
• Whole-Exome Sequencing of an Exceptional Longevity Cohort. / 16.08.2019 / PubMed / Full text
• Differential Phagocytic Properties of CD45 Microglia and CD45 Brain Mononuclear Phagocytes-Activation and Age-Related Effects. / 2018 / PubMed / Full text
• Microglia and Aging: The Role of the TREM2-DAP12 and CX3CL1-CX3CR1 Axes. / 22.01.2018 / PubMed / Full text
• A Tale of Two Genes: Microglial Apoe and Trem2. / 19.09.2017 / PubMed / Full text
• TREM2, Microglia, and Neurodegenerative Diseases. / 06.2017 / PubMed / Full text
• Neuroprotective Effect of TREM-2 in Aging and Alzheimer's Disease Model. / 2017 / PubMed / Full text
• Cerebrospinal fluid soluble TREM2 in aging and Alzheimer's disease. / 27.04.2016 / PubMed / Full text
• Chronic consumption of a western diet induces robust glial activation in aging mice and in a mouse model of Alzheimer's disease. / 18.02.2016 / PubMed / Full text
• Dark microglia: A new phenotype predominantly associated with pathological states. / 05.2016 / PubMed / Full text
• TREM2 Overexpression has No Improvement on Neuropathology and Cognitive Impairment in Aging APPswe/PS1dE9 Mice. / 03.2017 / PubMed / Full text
• TREM2 sustains microglial expansion during aging and response to demyelination. / 05.2015 / PubMed / Full text

TSPO

• Age and Sex Influence the Neuro-inflammatory Response to a Peripheral Acute LPS Challenge. / 2019 / PubMed / Full text
• Upregulation of cannabinoid receptor type 2, but not TSPO, in senescence-accelerated neuroinflammation in mice: a positron emission tomography study. / 10.11.2019 / PubMed / Full text
• Effects of age, BMI and sex on the glial cell marker [[TSPO]] - a multicentre [ C]PBR28 HRRT PET study. / 10.2019 / PubMed / Full text
• Concentration, distribution, and influence of aging on the 18 kDa translocator protein in human brain: Implications for brain imaging studies. / 05.2020 / PubMed / Full text
• Microglial response to increasing amyloid load saturates with aging: a longitudinal dual tracer in vivo μPET-study. / 06.11.2018 / PubMed / Full text
• Age Influences Microglial Activation After Cuprizone-Induced Demyelination. / 2018 / PubMed / Full text
• [[TSPO]] ligand PK11195 improves Alzheimer-related outcomes in aged female 3xTg-AD mice. / 14.09.2018 / PubMed / Full text
• Imaging studies of the HIV-infected brain. / 2018 / PubMed / Full text
• Steroidogenic abnormalities in translocator protein knockout mice and significance in the aging male. / 02.01.2018 / PubMed / Full text
• Time Courses of Cortical Glucose Metabolism and Microglial Activity Across the Life Span of Wild-Type Mice: A PET Study. / 12.2017 / PubMed / Full text
• Depiction of microglial activation in aging and dementia: Positron emission tomography with [ C]DPA713 versus [ C]( R)PK11195. / 03.2017 / PubMed / Full text
• In Vivo Detection of Age- and Disease-Related Increases in Neuroinflammation by 18F-GE180 [[TSPO]] MicroPET Imaging in Wild-Type and Alzheimer's Transgenic Mice. / 25.11.2015 / PubMed / Full text
• [[TSPO]] in a murine model of Sandhoff disease: presymptomatic marker of neurodegeneration and disease pathophysiology. / 01.2016 / PubMed / Full text
• Translocator protein: pharmacology and steroidogenesis. / 08.2015 / PubMed / Full text
• Translocator protein (TSPO) role in aging and Alzheimer's disease. / 2014 / PubMed / Full text
• Evaluation of basal ganglia and thalamic inflammation in children with pediatric autoimmune neuropsychiatric disorders associated with streptococcal infection and tourette syndrome: a positron emission tomographic (PET) study using 11C-[R]-PK11195. / 05.2015 / PubMed / Full text
• Genetic analysis of d[[TSPO]], an outer mitochondrial membrane protein, reveals its functions in apoptosis, longevity, and Ab42-induced neurodegeneration. / 06.2014 / PubMed / Full text
• Comparing amyloid-β deposition, neuroinflammation, glucose metabolism, and mitochondrial complex I activity in brain: a PET study in aged monkeys. / 11.2014 / PubMed / Full text

UCP2

• Potential Role of Leptin in Cardiac Steatosis Induced by Highly Saturated Fat Intake during Adolescence. / 10.2019 / PubMed / Full text
• Effect of Initial Aging and High-Fat/High-Fructose Diet on Mitochondrial Bioenergetics and Oxidative Status in Rat Brain. / 11.2019 / PubMed / Full text
• Decreased uncoupling protein 2 expression in aging retinal pigment epithelial cells. / 2019 / PubMed / Full text
• The Role of Genetic Profile in Functional Performance Adaptations to Exercise Training or Physical Activity: A Systematic Review of the Literature. / 01.08.2019 / PubMed / Full text
• G-1 exhibit antidepressant effect, increase of hippocampal ERs expression and improve hippocampal redox status in aged female rats. / 01.02.2019 / PubMed / Full text
• Rapamycin increases oxidative metabolism and enhances metabolic flexibility in human cardiac fibroblasts. / 21.06.2018 / PubMed / Full text
• Sestrin2 prevents age-related intolerance to post myocardial infarction via AMPK/PGC-1α pathway. / 02.2018 / PubMed / Full text
• Pleiotropic effects of UCP2-UCP3 variability on leucocyte telomere length and glucose homeostasis. / 06.2017 / PubMed / Full text
• Thyroid hormone-stimulated increases in PGC-1α and UCP2 promote life history-specific endocrine changes and maintain a lipid-based metabolism. / 01.02.2017 / PubMed / Full text
• Uncoupling protein 2 deficiency results in higher neutrophil counts and lower B-cell counts during aging in mice. / 11.2016 / PubMed / Full text
• Voluntary Running Aids to Maintain High Body Temperature in Rats Bred for High Aerobic Capacity. / 2016 / PubMed / Full text
• Uncoupling protein 2 protects mice from aging. / 09.2016 / PubMed / Full text
• Single nucleotide polymorphisms linked to mitochondrial uncoupling protein genes UCP2 and UCP3 affect mitochondrial metabolism and healthy aging in female nonagenarians. / 08.2016 / PubMed / Full text
• Differential modulation of AMPK/PPARα/UCP2 axis in relation to hypertension and aging in the brain, kidneys and heart of two closely related spontaneously hypertensive rat strains. / 07.08.2015 / PubMed / Full text
• [Genotype and allele frequencies of UCP and PPAR gene families in residents of besieged Leningrad and in the control group]. / 2014 / PubMed
• Activation of PPAR-γ by pioglitazone attenuates oxidative stress in aging rat cerebral arteries through upregulating UCP2. / 12.2014 / PubMed / Full text
• Loss of UCP2 attenuates mitochondrial dysfunction without altering ROS production and uncoupling activity. / 06.2014 / PubMed / Full text
• Contribution of genetic polymorphisms on functional status at very old age: a gene-based analysis of 38 genes (311 SNPs) in the oxidative stress pathway. / 04.2014 / PubMed / Full text

CXCL10

• Age-related decline of interferon-gamma responses in macrophage impairs satellite cell proliferation and regeneration. / 10.2020 / PubMed / Full text
• Neuroprotective effects of targeting BET proteins for degradation with dBET1 in aged mice subjected to ischemic stroke. / 07.2019 / PubMed / Full text
• Towards frailty biomarkers: Candidates from genes and pathways regulated in aging and age-related diseases. / 11.2018 / PubMed / Full text
• Age-related pro-inflammatory and pro-angiogenic changes in human aqueous humor. / 2018 / PubMed / Full text
• Aged Chinese-origin rhesus macaques infected with SIV develop marked viremia in absence of clinical disease, inflammation or cognitive impairment. / 01.02.2018 / PubMed / Full text
• Immune senescence and biomarkers profile of Bambuí aged population-based cohort. / 03.2018 / PubMed / Full text
• Dysregulation of C-X-C motif ligand 10 during aging and association with cognitive performance. / 03.2018 / PubMed / Full text
• Selected life-extending interventions reduce arterial CXCL10 and macrophage colony-stimulating factor in aged mouse arteries. / 08.2017 / PubMed / Full text
• Interferon-gamma deficiency protects against aging-related goblet cell loss. / 04.10.2016 / PubMed / Full text
• Behaviour and cognitive changes correlated with hippocampal neuroinflammaging and neuronal markers in female SAMP8, a model of accelerated senescence. / 07.2016 / PubMed / Full text
• In vitro cytokine induction by TLR-activating vaccine adjuvants in human blood varies by age and adjuvant. / 07.2016 / PubMed / Full text
• Thinning of the RPE and choroid associated with T lymphocyte recruitment in aged and light-challenged mice. / 2015 / PubMed / Full text
• CCL2, CXCL8, CXCL9 and CXCL10 serum levels increase with age but are not altered by treatment with hydroxychloroquine in patients with osteoarthritis of the knees. / 12.2017 / PubMed / Full text
• Cathelicidin related antimicrobial peptide, laminin, Toll-like receptors and chemokines levels in experimental hypersensitivity pneumonitis in mice. / 06.2015 / PubMed / Full text
• Viremic and Virologically Suppressed HIV Infection Increases Age-Related Changes to Monocyte Activation Equivalent to 12 and 4 Years of Aging, Respectively. / 01.05.2015 / PubMed / Full text
• Increased recruitment of bone marrow-derived cells into the brain associated with altered brain cytokine profile in senescence-accelerated mice. / 04.2016 / PubMed / Full text
• Dendritic cells from aged subjects contribute to chronic airway inflammation by activating bronchial epithelial cells under steady state. / 11.2014 / PubMed / Full text

FAS

• Five-year change in maximum tongue pressure and physical function in community-dwelling elderly adults. / 09.2020 / PubMed / Full text
• Inhibition of USP7 activity selectively eliminates senescent cells in part via restoration of p53 activity. / 03.2020 / PubMed / Full text
• Application of GFR estimation equations in elderly patients with measured GFR below 60 mL/min/1.73 m . / 03.2020 / PubMed / Full text
• Dietary methionine increased the lipid accumulation in juvenile tiger puffer Takifugu rubripes. / 04.2019 / PubMed / Full text
• Genetic and Environmental Influences on Language Ability in Older Adults: Findings from the Older Australian Twins Study. / 05.2018 / PubMed / Full text
• Effects of aging on fat deposition and meat quality in Sheldrake duck. / 01.06.2018 / PubMed / Full text
• Impact of sociodemographic variables on executive functions. / 01-03.2017 / PubMed / Full text
• Prevalence of Impaired Kidney Function in the German Elderly: Results from the Berlin Aging Study II (BASE-II). / 2017 / PubMed / Full text
• Multiple category verbal fluency in mild cognitive impairment and correlation with CSF biomarkers for Alzheimer's disease. / 06.2017 / PubMed / Full text
• Glomerular Filtration Rate in Healthy Living Potential Kidney Donors: A Meta-Analysis Supporting the Construction of the Full Age Spectrum Equation. / 2017 / PubMed / Full text
• Life Expectancy of People with Fetal Alcohol Syndrome. / 2016 / PubMed
• Increased susceptibility of CD4 T cells from elderly individuals to HIV-1 infection and apoptosis is associated with reduced CD4 and enhanced CXCR4 and FAS surface expression levels. / 09.10.2015 / PubMed / Full text
• Systemic Akt1 Deletion after Tumor Onset in p53(-/-) Mice Increases Lifespan and Regresses Thymic Lymphoma Emulating p53 Restoration. / 28.07.2015 / PubMed / Full text
• Impact of loss of NF-κB1, NF-κB2 or c-REL on SLE-like autoimmune disease and lymphadenopathy in Fas(lpr/lpr) mutant mice. / 01.2016 / PubMed / Full text
• Longitudinal measures of perfluoroalkyl substances (PFAS) in serum of Gullah African Americans in South Carolina: 2003-2013. / 11.2015 / PubMed / Full text
• White Adipose Tissue Depot-Specific Activity of Lipogenic Enzymes in Response to Fasting and Refeeding in Young and Old Rats. / 2015 / PubMed / Full text
• Short-term calorie restriction and refeeding differently affect lipogenic enzymes in major white adipose tissue depots of young and old rats. / 02.2014 / PubMed

FH

• Genetic Factors of Alzheimer's Disease Modulate How Diet is Associated with Long-Term Cognitive Trajectories: A UK Biobank Study. / 2020 / PubMed / Full text
• Volumetric alterations in the hippocampal subfields of subjects at increased risk of dementia. / 07.2020 / PubMed / Full text
• Macroscopic hematuria as a risk factor for hypertension in ageing people with hemophilia and a family history of hypertension. / 02.2020 / PubMed / Full text
• LDL Receptor Deficiency Does not Alter Brain Amyloid-β Levels but Causes an Exacerbation of Apoptosis. / 2020 / PubMed / Full text
• Sex differences in cholesterol levels from birth to 19 years of age may lead to increased cholesterol burden in females with FH. / 05-06.2018 / PubMed / Full text
• Association between lipoprotein (a) and proprotein convertase substilisin/kexin type 9 in patients with heterozygous familial hypercholesterolemia: A case-control study. / 02.2018 / PubMed / Full text
• Longitudinal Assessment of Self- and Informant-Subjective Cognitive Complaints in a Sample of Healthy Late-Middle Aged Adults Enriched with a Family History of Alzheimer's Disease. / 09.2017 / PubMed / Full text
• Diffusion Tensor Imaging Predictors of Episodic Memory Decline in Healthy Elders at Genetic Risk for Alzheimer's Disease. / 11.2016 / PubMed / Full text
• Familial hypercholesterolaemia reduces the quality of life of patients not reaching treatment targets. / 05.2016 / PubMed
• Effect of fetal hypothyroidism on tolerance to ischemia-reperfusion injury in aged male rats: Role of nitric oxide. / 01.05.2016 / PubMed / Full text
• Familial hypercholesterolaemia in children and adolescents: gaining decades of life by optimizing detection and treatment. / 21.09.2015 / PubMed / Full text
• Impact of family history of alcoholism on glutamine/glutamate ratio in anterior cingulate cortex in substance-naïve adolescents. / 12.2015 / PubMed / Full text
• Age-Based Differences in the Genetic Determinants of Glycemic Control: A Case of FOXO3 Variations. / 2015 / PubMed / Full text
• The Mechanism of Ligamentum Flavum Hypertrophy: Introducing Angiogenesis as a Critical Link That Couples Mechanical Stress and Hypertrophy. / 08.2015 / PubMed / Full text
• Longitudinal measures of perfluoroalkyl substances (PFAS) in serum of Gullah African Americans in South Carolina: 2003-2013. / 11.2015 / PubMed / Full text
• FDG and Amyloid PET in Cognitively Normal Individuals at Risk for Late-Onset Alzheimer's Disease. / 04.2014 / PubMed / Full text
• Randomized trial of the ForeseeHome monitoring device for early detection of neovascular age-related macular degeneration. The HOme Monitoring of the Eye (HOME) study design - HOME Study report number 1. / 03.2014 / PubMed / Full text

GDNF

• GFR-α1 Expression in Substantia Nigra Increases Bilaterally Following Unilateral Striatal GDNF in Aged Rats and Attenuates Nigral Tyrosine Hydroxylase Loss Following 6-OHDA Nigrostriatal Lesion. / 16.10.2019 / PubMed / Full text
• The Gender-Biased Effects of Intranasal MPTP Administration on Anhedonic- and Depressive-Like Behaviors in C57BL/6 Mice: the Role of Neurotrophic Factors. / 11.2018 / PubMed / Full text
• Analysis of neurotrophic and antioxidant factors related to midbrain dopamine neuronal loss and brain inflammation in the cerebrospinal fluid of the elderly. / 09.2018 / PubMed / Full text
• Glial cell line-derived neurotrophic factor (GDNF) attenuates the peripheral neuromuscular dysfunction without inhibiting the activation of spinal microglia/monocyte. / 09.05.2018 / PubMed / Full text
• Aging-related limit of exercise efficacy on motor decline. / 2017 / PubMed / Full text
• The Noradrenergic System of Aged GDNF Heterozygous Mice. / 04.2003 / PubMed / Full text
• Age-associated decrease in GDNF and its cognate receptor GFRα-1 protein expression in human skin. / 06.2016 / PubMed / Full text
• Effect of age on expression of spermatogonial markers in bovine testis and isolated cells. / 07.2016 / PubMed / Full text
• Human neural progenitors differentiate into astrocytes and protect motor neurons in aging rats. / 06.2016 / PubMed / Full text
• Exercise-Mediated Increase in Nigral Tyrosine Hydroxylase Is Accompanied by Increased Nigral GFR-α1 and EAAC1 Expression in Aging Rats. / 17.02.2016 / PubMed / Full text
• Mechanisms of Muscle Denervation in Aging: Insights from a Mouse Model of Amyotrophic Lateral Sclerosis. / 09.2015 / PubMed / Full text
• The involvement of BDNF, NGF and GDNF in aging and Alzheimer's disease. / 09.2015 / PubMed / Full text
• Symptomatic improvement, increased life-span and sustained cell homing in amyotrophic lateral sclerosis after transplantation of human umbilical cord blood cells genetically modified with adeno-viral vectors expressing a neuro-protective factor and a neural cell adhesion molecule. / 2015 / PubMed / Full text
• Effects of aging on glutamate neurotransmission in the substantia nigra of Gdnf heterozygous mice. / 03.2015 / PubMed / Full text
• Age and lesion-induced increases of GDNF transgene expression in brain following intracerebral injections of DNA nanoparticles. / 22.01.2015 / PubMed / Full text
• Astrocytes show reduced support of motor neurons with aging that is accelerated in a rodent model of ALS. / 02.2015 / PubMed / Full text
• GDNF and GFRα co-receptor family in the developing feline gut. / 09.2014 / PubMed / Full text

KLF4

• Extracellular Vesicles from Healthy Cells Improves Cell Function and Stemness in Premature Senescent Stem Cells by miR-302b and HIF-1α Activation. / 25.06.2020 / PubMed / Full text
• Soluble klotho regulates the function of salivary glands by activating KLF4 pathways. / 02.10.2019 / PubMed / Full text
• Centenarians Overexpress Pluripotency-Related Genes. / 16.08.2019 / PubMed / Full text
• A SIRT1-centered circuitry regulates breast cancer stemness and metastasis. / 12.2018 / PubMed / Full text
• miR-10a rejuvenates aged human mesenchymal stem cells and improves heart function after myocardial infarction through KLF4. / 30.05.2018 / PubMed / Full text
• MYC Releases Early Reprogrammed Human Cells from Proliferation Pause via Retinoblastoma Protein Inhibition. / 10.04.2018 / PubMed / Full text
• Kruppel-like factor 4 regulates keratinocyte senescence. / 05.05.2018 / PubMed / Full text
• Role of CD133 Molecule in Wnt Response and Renal Repair. / 03.2018 / PubMed / Full text
• Coupling shRNA screens with single-cell RNA-seq identifies a dual role for mTOR in reprogramming-induced senescence. / 15.10.2017 / PubMed / Full text
• ZSCAN10 expression corrects the genomic instability of iPSCs from aged donors. / 09.2017 / PubMed / Full text
• Induced Pluripotent Stem Cell-Derived Dopaminergic Neurons from Adult Common Marmoset Fibroblasts. / 01.09.2017 / PubMed / Full text
• Role of p16 and BMI-1 in oxidative stress-induced premature senescence in human dental pulp stem cells. / 08.2017 / PubMed / Full text
• Overexpression of KLF4 promotes cell senescence through microRNA-203-survivin-p21 pathway. / 13.09.2016 / PubMed / Full text
• Adipose-derived stem cells from lean and obese humans show depot specific differences in their stem cell markers, exosome contents and senescence: role of protein kinase C delta (PKCδ) in adipose stem cell niche. / 2016 / PubMed / Full text
• KLF4 deletion alters gastric cell lineage and induces MUC2 expression. / 09.06.2016 / PubMed / Full text
• Critical role of the miR-200 family in regulating differentiation and proliferation of neurons. / 06.2015 / PubMed / Full text
• Oxidative DNA damage causes premature senescence in mouse embryonic fibroblasts deficient for Krüppel-like factor 4. / 09.2015 / PubMed / Full text

LPO

• [Features of the changes in lipid peroxidation and activity of Na /K -ATPase in the brain of the aged rats in the conditions of two-vessel cerebral ischemia/reperfusion.] / 2019 / PubMed
• Exercise training initiated at old stage of lifespan attenuates aging-and ovariectomy-induced cardiac and renal oxidative stress: Role of baroreflex. / 09.2019 / PubMed / Full text
• Tris(1,3-dichloro-2-propyl) phosphate accelerated the aging process induced by the 4-hydroxynon-2-enal response to reactive oxidative species in Caenorhabditis elegans. / 03.2019 / PubMed / Full text
• Physical Exercise Attenuates Oxidative Stress and Morphofunctional Cerebellar Damages Induced by the Ethanol Binge Drinking Paradigm from Adolescence to Adulthood in Rats. / 2019 / PubMed / Full text
• [Effect of cryopreserved cord blood nucleated cells on course of pathological processes in progressive aging of brain (experimental study).] / 2018 / PubMed
• Analysis of Plasma MicroRNAs as Predictors and Biomarkers of Aging and Frailty in Humans. / 2018 / PubMed / Full text
• ERCC1-deficient cells and mice are hypersensitive to lipid peroxidation. / 20.08.2018 / PubMed / Full text
• Antioxidant action of grape seed polyphenols and aerobic exercise in improving neuronal number in the hippocampus is associated with decrease in lipid peroxidation and hydrogen peroxide in adult and middle-aged rats. / 01.2018 / PubMed / Full text
• The antioxidative and anti-aging effects of acidic- and alkalic-extractable mycelium polysaccharides by Agrocybe aegerita (Brig.) Sing. / 01.2018 / PubMed / Full text
• Aging modifies daily variation of antioxidant enzymes and oxidative status in the hippocampus. / 02.2017 / PubMed / Full text
• Lipid peroxidation in face of DNA damage, DNA repair and other cellular processes. / 06.2017 / PubMed / Full text
• An iron-deficient diet during development induces oxidative stress in relation to age and gender in Wistar rats. / 02.2017 / PubMed / Full text
• Age-Dependent Changes in Na( ),K( )-ATPase Activity and Lipid Peroxidation in Membranes of Erythrocytes during Cardiosclerosis Development in Rats. / 06.2016 / PubMed / Full text
• Purple sweet potato anthocyanin attenuates fat-induced mortality in Drosophila melanogaster. / 09.2016 / PubMed / Full text
• n-3 fatty acids effectively improve the reference memory-related learning ability associated with increased brain docosahexaenoic acid-derived docosanoids in aged rats. / 02.2015 / PubMed / Full text
• Pectinase-treated Panax ginseng extract (GINST) rescues testicular dysfunction in aged rats via redox-modulating proteins. / 05.2014 / PubMed / Full text
• Antioxidant role of oleuropein on midbrain and dopaminergic neurons of substantia nigra in aged rats. / 2014 / PubMed / Full text

MTR

• Amide proton transfer-weighted magnetic resonance imaging of human brain aging at 3 Tesla. / 03.2020 / PubMed / Full text
• One-carbon metabolism gene polymorphisms are associated with cognitive trajectory among African-American adults. / 12.2019 / PubMed / Full text
• Test-retest reliability of myelin imaging in the human spinal cord: Measurement errors versus region- and aging-induced variations. / 2018 / PubMed / Full text
• Alterations in brain white matter contributing to age-related slowing of task switching performance: The role of radial diffusivity and magnetization transfer ratio. / 11.2016 / PubMed / Full text
• Development and aging of superficial white matter myelin from young adulthood to old age: Mapping by vertex-based surface statistics (VBSS). / 05.2016 / PubMed / Full text
• Moderate treadmill running exercise prior to tendon injury enhances wound healing in aging rats. / 23.02.2016 / PubMed / Full text
• Nutritional habits, lifestyle, and genetic predisposition in cardiovascular and metabolic traits in Turkish population. / 06.2016 / PubMed / Full text
• Age-effects in white matter using associated diffusion tensor imaging and magnetization transfer ratio during late childhood and early adolescence. / 05.2016 / PubMed / Full text
• Associations between insulin action and integrity of brain microstructure differ with familial longevity and with age. / 2015 / PubMed / Full text
• An in vivo study on brain microstructure in biological and chronological ageing. / 2015 / PubMed / Full text
• White matter hyperintensities and normal-appearing white matter integrity in the aging brain. / 02.2015 / PubMed / Full text
• Structural covariance of superficial white matter in mild Alzheimer's disease compared to normal aging. / 09.2014 / PubMed / Full text
• Magnetization transfer ratio relates to cognitive impairment in normal elderly. / 2014 / PubMed / Full text
• Gender, age-related, and regional differences of the magnetization transfer ratio of the cortical and subcortical brain gray matter. / 08.2014 / PubMed / Full text
• Age independently affects myelin integrity as detected by magnetization transfer magnetic resonance imaging in multiple sclerosis. / 2014 / PubMed / Full text
• Magnetization transfer imaging for in vivo detection of microstructural tissue changes in aging and dementia: a short literature review. / 2014 / PubMed / Full text
• Quantitative multi-modal MRI of the Hippocampus and cognitive ability in community-dwelling older subjects. / 04.2014 / PubMed / Full text

NOX4

• Sestrin2 Attenuates Cellular Senescence by Inhibiting NADPH Oxidase 4 Expression. / 24.11.2020 / PubMed / Full text
• NADPH Oxidases and Aging Models of Lung Fibrosis. / 2019 / PubMed / Full text
• Age-related distribution and potential role of SNCB in topographically different retinal areas of the common marmoset Callithrix jacchus, including the macula. / 08.2019 / PubMed / Full text
• Expression of lipogenic markers is decreased in subcutaneous adipose tissue and adipocytes of older women and is negatively linked to GDF15 expression. / 08.2019 / PubMed / Full text
• Redox Imbalance in Idiopathic Pulmonary Fibrosis: A Role for Oxidant Cross-Talk Between NADPH Oxidase Enzymes and Mitochondria. / 10.11.2019 / PubMed / Full text
• NADPH oxidase 4 mediates ROS production in radiation-induced senescent cells and promotes migration of inflammatory cells. / 01.2018 / PubMed / Full text
• Alternative Splicing of NOX4 in the Failing Human Heart. / 2017 / PubMed / Full text
• Cooperation between p21 and Akt is required for p53-dependent cellular senescence. / 10.2017 / PubMed / Full text
• Mcl-1 regulates reactive oxygen species via NOX4 during chemotherapy-induced senescence. / 25.04.2017 / PubMed / Full text
• PPARα activation by MHY908 attenuates age-related renal inflammation through modulation of the ROS/Akt/FoxO1 pathway. / 06.2017 / PubMed / Full text
• NADPH oxidase 4 regulates vascular inflammation in aging and atherosclerosis. / 01.2017 / PubMed / Full text
• NOX4 downregulation leads to senescence of human vascular smooth muscle cells. / 11.10.2016 / PubMed / Full text
• Reactive oxygen species: The good, the bad, and the enigma. / 07-09.2014 / PubMed / Full text
• Interferon gamma/NADPH oxidase defense system in immunity and cancer. / 02.2016 / PubMed / Full text
• NOS1 induces NADPH oxidases and impairs contraction kinetics in aged murine ventricular myocytes. / 09.2015 / PubMed / Full text
• NOX4 NADPH Oxidase-Dependent Mitochondrial Oxidative Stress in Aging-Associated Cardiovascular Disease. / 20.12.2015 / PubMed / Full text
• The imbalanced redox status in senescent endothelial cells is due to dysregulated Thioredoxin-1 and NADPH oxidase 4. / 08.2014 / PubMed / Full text

PARP1

• Topological DNA damage, telomere attrition and T cell senescence during chronic viral infections. / 2019 / PubMed / Full text
• PARP1 inhibitor (PJ34) improves the function of aging-induced endothelial progenitor cells by preserving intracellular NAD levels and increasing SIRT1 activity. / 23.08.2018 / PubMed / Full text
• Maternal high calorie diet induces mitochondrial dysfunction and senescence phenotype in subcutaneous fat of newborn mice. / 13.10.2017 / PubMed / Full text
• Acute telomerase components depletion triggers oxidative stress as an early event previous to telomeric shortening. / 04.2018 / PubMed / Full text
• Molecular evolutionary patterns of NAD /Sirtuin aging signaling pathway across taxa. / 2017 / PubMed / Full text
• The NAD /PARP1/SIRT1 Axis in Aging. / 06.2017 / PubMed / Full text
• A conserved NAD binding pocket that regulates protein-protein interactions during aging. / 24.03.2017 / PubMed / Full text
• Melatonin regulates PARP1 to control the senescence-associated secretory phenotype (SASP) in human fetal lung fibroblast cells. / 08.2017 / PubMed / Full text
• The Ubiquitin-like with PHD and Ring Finger Domains 1 (UHRF1)/DNA Methyltransferase 1 (DNMT1) Axis Is a Primary Regulator of Cell Senescence. / 03.03.2017 / PubMed / Full text
• A serum miRNA profile of human longevity: findings from the Baltimore Longitudinal Study of Aging (BLSA). / 07.11.2016 / PubMed / Full text
• Cockayne syndrome group A and B proteins converge on transcription-linked resolution of non-B DNA. / 01.11.2016 / PubMed / Full text
• Sperm-associated antigen 9 (SPAG9) promotes the survival and tumor growth of triple-negative breast cancer cells. / 10.2016 / PubMed / Full text
• Differential cytotoxicity induced by the Titanium(IV)Salan complex Tc52 in G2-phase independent of DNA damage. / 13.07.2016 / PubMed / Full text
• All-trans retinoic acid and rapamycin normalize Hutchinson Gilford progeria fibroblast phenotype. / 06.10.2015 / PubMed / Full text
• SIRT6 rescues the age related decline in base excision repair in a PARP1-dependent manner. / 2015 / PubMed / Full text
• RecQ helicases and PARP1 team up in maintaining genome integrity. / 09.2015 / PubMed / Full text
• Mechanisms controlling the smooth muscle cell death in progeria via down-regulation of poly(ADP-ribose) polymerase 1. / 03.06.2014 / PubMed / Full text

ADAM10

• NKG2D Ligand Shedding in Response to Stress: Role of ADAM10. / 2020 / PubMed / Full text
• Chronic Mild Stress Modified Epigenetic Mechanisms Leading to Accelerated Senescence and Impaired Cognitive Performance in Mice. / 10.02.2020 / PubMed / Full text
• Removal of p75 Neurotrophin Receptor Expression from Cholinergic Basal Forebrain Neurons Reduces Amyloid-β Plaque Deposition and Cognitive Impairment in Aged APP/PS1 Mice. / 07.2019 / PubMed / Full text
• 11β-HSD1 Inhibition by RL-118 Promotes Autophagy and Correlates with Reduced Oxidative Stress and Inflammation, Enhancing Cognitive Performance in SAMP8 Mouse Model. / 12.2018 / PubMed / Full text
• Effects of senescence and angiotensin II on expression and processing of amyloid precursor protein in human cerebral microvascular endothelial cells. / 15.01.2018 / PubMed / Full text
• microRNA 221 Targets ADAM10 mRNA and is Downregulated in Alzheimer's Disease. / 2018 / PubMed / Full text
• Human Plasma Thioredoxin-80 Increases With Age and in ApoE Mice Induces Inflammation, Angiogenesis, and Atherosclerosis. / 01.08.2017 / PubMed / Full text
• Ionizing radiation reduces ADAM10 expression in brain microvascular endothelial cells undergoing stress-induced senescence. / 04.2017 / PubMed / Full text
• Regulation of Alpha-Secretase ADAM10 [i]In vitro[/i] and [i]In vivo[/i]: Genetic, Epigenetic, and Protein-Based Mechanisms. / 2017 / PubMed / Full text
• Sideritis spp. Extracts Enhance Memory and Learning in Alzheimer's β-Amyloidosis Mouse Models and Aged C57Bl/6 Mice. / 31.05.2016 / PubMed / Full text
• Effects of Sesaminol Feeding on Brain Aβ Accumulation in a Senescence-Accelerated Mouse-Prone 8. / 22.06.2016 / PubMed / Full text
• Behaviour and cognitive changes correlated with hippocampal neuroinflammaging and neuronal markers in female SAMP8, a model of accelerated senescence. / 07.2016 / PubMed / Full text
• Epigenetic mechanisms underlying cognitive impairment and Alzheimer disease hallmarks in 5XFAD mice. / 04.2016 / PubMed / Full text
• Increase of α-Secretase ADAM10 in Platelets Along Cognitively Healthy Aging. / 2016 / PubMed / Full text
• ADAM10 gene expression in the blood cells of Alzheimer's disease patients and mild cognitive impairment subjects. / 2015 / PubMed / Full text
• Serum Fragments of Tau for the Differential Diagnosis of Alzheimer's Disease. / 2015 / PubMed / Full text

ALDH2

• Aldehyde Dehydrogenase 2 (ALDH2) and Aging: Is There a Sensible Link? / 2019 / PubMed / Full text
• Appropriate dose of ethanol exerts anti-senescence and anti-atherosclerosis protective effects by activating ALDH2. / 30.04.2019 / PubMed / Full text
• Impaired enzymatic reactive aldehyde-detoxifying capacity and glutathione peroxidase activity in the aged human arterial tissue. / 02.2019 / PubMed / Full text
• Telomere shortening in alcohol dependence: Roles of alcohol and acetaldehyde. / 02.2019 / PubMed / Full text
• Aldehyde dehydrogenase 2 deficiency promotes atherosclerotic plaque instability through accelerating mitochondrial ROS-mediated vascular smooth muscle cell senescence. / 01.07.2019 / PubMed / Full text
• ALDH2 mediates the dose-response protection of chronic ethanol against endothelial senescence through SIRT1/p53 pathway. / 12.10.2018 / PubMed / Full text
• Effects of the common polymorphism in the human aldehyde dehydrogenase 2 (ALDH2) gene on the lung. / 21.04.2017 / PubMed / Full text
• Complex inhibition of autophagy by mitochondrial aldehyde dehydrogenase shortens lifespan and exacerbates cardiac aging. / 08.2017 / PubMed / Full text
• Behaviour and cognitive changes correlated with hippocampal neuroinflammaging and neuronal markers in female SAMP8, a model of accelerated senescence. / 07.2016 / PubMed / Full text
• Associations Between Alcohol Consumption and Leukocyte Telomere Length Modified by a Common Polymorphism of ALDH2. / 04.2016 / PubMed / Full text
• Relationships of alcohol dehydrogenase 1B (ADH1B) and aldehyde dehydrogenase 2 (ALDH2) genotypes with alcohol sensitivity, drinking behavior and problem drinking in Japanese older men. / 05.2016 / PubMed / Full text
• Aldehyde dehydrogenase 2 activation in aged heart improves the autophagy by reducing the carbonyl modification on SIRT1. / 19.01.2016 / PubMed / Full text
• Characterization of Aldh2 (-/-) mice as an age-related model of cognitive impairment and Alzheimer's disease. / 25.04.2015 / PubMed / Full text
• Ethanol reduces lifespan, body weight, and serum alanine aminotransferase level of aldehyde dehydrogenase 2 knockout mouse. / 07.2014 / PubMed / Full text
• Mitochondrial aldehyde dehydrogenase 2 accentuates aging-induced cardiac remodeling and contractile dysfunction: role of AMPK, Sirt1, and mitochondrial function. / 06.2014 / PubMed / Full text
• Targeting aldehyde dehydrogenase 2: new therapeutic opportunities. / 01.2014 / PubMed / Full text

BCR

• The presence of CLL-associated stereotypic B cell receptors in the normal BCR repertoire from healthy individuals increases with age. / 2019 / PubMed / Full text
• Crucial Role of Increased Arid3a at the Pre-B and Immature B Cell Stages for B1a Cell Generation. / 2019 / PubMed / Full text
• Effect of Age on NK Cell Compartment in Chronic Myeloid Leukemia Patients Treated With Tyrosine Kinase Inhibitors. / 2018 / PubMed / Full text
• B cell responses to apoptotic cells in MFG-E8-/- mice. / 2018 / PubMed / Full text
• Early Generated B-1-Derived B Cells Have the Capacity To Progress To Become Mantle Cell Lymphoma-like Neoplasia in Aged Mice. / 15.07.2018 / PubMed / Full text
• Mean residual life regression with functional principal component analysis on longitudinal data for dynamic prediction. / 12.2018 / PubMed / Full text
• NLR Nod1 signaling promotes survival of BCR-engaged mature B cells through up-regulated Nod1 as a positive outcome. / 02.10.2017 / PubMed / Full text
• Phylogenetic analysis of the human antibody repertoire reveals quantitative signatures of immune senescence and aging. / 31.01.2017 / PubMed / Full text
• Immunosenescence-Related Transcriptomic and Immunologic Changes in Older Individuals Following Influenza Vaccination. / 2016 / PubMed / Full text
• 4-methylumbelliferone and imatinib combination enhances senescence induction in chronic myeloid leukemia cell lines. / 02.2017 / PubMed / Full text
• Hyaluronan oligomers sensitize chronic myeloid leukemia cell lines to the effect of Imatinib. / 04.2016 / PubMed / Full text
• Aging-associated inflammation promotes selection for adaptive oncogenic events in B cell progenitors. / 12.2015 / PubMed / Full text
• The ageing human B cell repertoire: a failure of selection? / 01.2016 / PubMed / Full text
• Age stratified comparative analysis of perioperative, functional and oncologic outcomes in patients after robot assisted radical prostatectomy--A propensity score matched study. / 07.2015 / PubMed / Full text
• Double negative (CD19 IgG IgD-CD27-) B lymphocytes: a new insight from telomerase in healthy elderly, in centenarian offspring and in Alzheimer's disease patients. / 11.2014 / PubMed / Full text
• Memory B cells form in aged mice despite impaired affinity maturation and germinal center kinetics. / 06.2014 / PubMed / Full text

CD19

• Sequential treatment with aT19 cells generates memory CAR-T cells and prolongs the lifespan of Raji-B-NDG mice. / 28.01.2020 / PubMed / Full text
• Stress-Induced Premature Senescence Promotes Proliferation by Activating the [i]SENEX[/i] and p16 /Retinoblastoma (Rb) Pathway in Diffuse Large B-Cell Lymphoma / 18.11.2019 / PubMed / Full text
• Effects of pepsin and pepstatin on reflux tonsil hypertrophy in vitro. / 2018 / PubMed / Full text
• Innate and adaptive immune dysregulation in critically ill ICU patients. / 05.07.2018 / PubMed / Full text
• Vitamin D levels correlate with lymphocyte subsets in elderly patients with age-related diseases. / 16.05.2018 / PubMed / Full text
• Normal variation of bone marrow B-cell precursors according to age - reference ranges for studies in myelodysplastic syndromes in Brazil. / 09.2018 / PubMed / Full text
• Altered marginal zone and innate-like B cells in aged senescence-accelerated SAMP8 mice with defective IgG1 responses. / 17.08.2017 / PubMed / Full text
• Different therapeutic effects of cells derived from human amniotic membrane on premature ovarian aging depend on distinct cellular biological characteristics. / 27.07.2017 / PubMed / Full text
• Immune biomarkers in older adults: Role of physical activity. / 2017 / PubMed / Full text
• A lifetime aging study of human CD19 transgenic mice. / 06.2017 / PubMed / Full text
• Age-related arterial immune cell infiltration in mice is attenuated by caloric restriction or voluntary exercise. / 08.2018 / PubMed / Full text
• Alterations in B-cell subsets in pediatric patients with early atopic dermatitis. / 07.2017 / PubMed / Full text
• Perturbed hematopoiesis in mice lacking ATMIN. / 20.10.2016 / PubMed / Full text
• Effects of Ageing on the Immune System: Infants to Elderly. / 04.2016 / PubMed / Full text
• Exome sequencing analysis reveals variants in primary immunodeficiency genes in patients with very early onset inflammatory bowel disease. / 11.2015 / PubMed / Full text
• [Effects of soluble egg antigen and adult worm antigen of Schistosoma japonicum on differentiation of effector B cells of mice]. / 10.2013 / PubMed

CDK2

• p57 is a master regulator of human adipose derived stem cell quiescence and senescence. / 04.2020 / PubMed / Full text
• Induction of Senescence in Cancer Cells by a Novel Combination of Cucurbitacin B and Withanone: Molecular Mechanism and Therapeutic Potential. / 22.05.2020 / PubMed / Full text
• Cyclin-Dependent Kinase 2 in Cellular Senescence and Cancer. A Structural and Functional Review. / 2019 / PubMed / Full text
• Tenovin-1 Induces Senescence and Decreases Wound-Healing Activity in Cultured Rat Primary Astrocytes. / 01.05.2019 / PubMed / Full text
• Relationship between intermuscular adipose tissue infiltration and myostatin before and after aerobic exercise training. / 01.09.2018 / PubMed / Full text
• Carvacrol nanoemulsion evokes cell cycle arrest, apoptosis induction and autophagy inhibition in doxorubicin resistant-A549 cell line. / 2018 / PubMed / Full text
• Gut flora-dependent metabolite Trimethylamine-N-oxide accelerates endothelial cell senescence and vascular aging through oxidative stress. / 20.02.2018 / PubMed / Full text
• Inhibition of CIP2A attenuates tumor progression by inducing cell cycle arrest and promoting cellular senescence in hepatocellular carcinoma. / 08.01.2018 / PubMed / Full text
• G protein-coupled receptor kinase 4-induced cellular senescence and its senescence-associated gene expression profiling. / 15.11.2017 / PubMed / Full text
• Pneumolysin induces cellular senescence by increasing ROS production and activation of MAPK/NF-κB signal pathway in glial cells. / 04.2017 / PubMed / Full text
• The protein-interaction network with functional roles in tumorigenesis, neurodegeneration, and aging. / 12.2016 / PubMed / Full text
• A steroid like phytochemical Antcin M is an anti-aging reagent that eliminates hyperglycemia-accelerated premature senescence in dermal fibroblasts by direct activation of Nrf2 and SIRT-1. / 27.09.2016 / PubMed / Full text
• Hyaluronan synthase 2 regulates fibroblast senescence in pulmonary fibrosis. / 09.2016 / PubMed / Full text
• Double staining of β-galactosidase with fibrosis and cancer markers reveals the chronological appearance of senescence in liver carcinogenesis induced by diethylnitrosamine. / 22.01.2016 / PubMed / Full text
• Proton irradiation impacts age-driven modulations of cancer progression influenced by immune system transcriptome modifications from splenic tissue. / 09.2015 / PubMed / Full text
• Age and the means of bypassing stasis influence the intrinsic subtype of immortalized human mammary epithelial cells. / 2015 / PubMed / Full text

CDK6

• Saturated Fatty Acids Promote Hepatocytic Senecence through Regulation of miR-34a/Cyclin-Dependent Kinase 6. / 24.09.2020 / PubMed / Full text
• Hepatoprotective effects of hydroxysafflor yellow A in D-galactose-treated aging mice. / 15.08.2020 / PubMed / Full text
• Anti-cell growth and anti-cancer stem cell activity of the CDK4/6 inhibitor palbociclib in breast cancer cells. / 05.2020 / PubMed / Full text
• Compromising the constitutive p16 expression sensitizes human neuroblastoma cells to Hsp90 inhibition and promotes premature senescence. / 04.2020 / PubMed / Full text
• Palbociclib Effectively Halts Proliferation but Fails to Induce Senescence in Patient-Derived Glioma Stem Cells. / 11.2019 / PubMed / Full text
• Avenanthramide A Induces Cellular Senescence via miR-129-3p/Pirh2/p53 Signaling Pathway To Suppress Colon Cancer Growth. / 01.05.2019 / PubMed / Full text
• Carvacrol nanoemulsion evokes cell cycle arrest, apoptosis induction and autophagy inhibition in doxorubicin resistant-A549 cell line. / 2018 / PubMed / Full text
• Preclinical characterization of abemaciclib in hormone receptor positive breast cancer. / 19.09.2017 / PubMed / Full text
• G protein-coupled receptor kinase 4-induced cellular senescence and its senescence-associated gene expression profiling. / 15.11.2017 / PubMed / Full text
• Genome-Wide Overexpression Screen Identifies Genes Able to Bypass p16-Mediated Senescence in Melanoma. / 03.2017 / PubMed / Full text
• p16INK4a suppresses BRCA1-deficient mammary tumorigenesis. / 20.12.2016 / PubMed / Full text
• A steroid like phytochemical Antcin M is an anti-aging reagent that eliminates hyperglycemia-accelerated premature senescence in dermal fibroblasts by direct activation of Nrf2 and SIRT-1. / 27.09.2016 / PubMed / Full text
• CDK4-CDK6 inhibitors induce autophagy-mediated degradation of DNMT1 and facilitate the senescence antitumor response. / 02.10.2016 / PubMed / Full text
• Sperm-associated antigen 9 (SPAG9) promotes the survival and tumor growth of triple-negative breast cancer cells. / 10.2016 / PubMed / Full text
• MicroRNA-33 promotes the replicative senescence of mouse embryonic fibroblasts by suppressing CDK6. / 13.05.2016 / PubMed / Full text
• MiR-506 suppresses proliferation and induces senescence by directly targeting the CDK4/6-FOXM1 axis in ovarian cancer. / 07.2014 / PubMed / Full text

CX3CR1

• Monocytes present age-related changes in phospholipid concentration and decreased energy metabolism. / 04.2020 / PubMed / Full text
• Muscle Injury Induces Postoperative Cognitive Dysfunction. / 17.02.2020 / PubMed / Full text
• Dexamethasone Induces a Specific Form of Ramified Dysfunctional Microglia. / 02.2019 / PubMed / Full text
• Surgical Trauma Exacerbates Cognitive Deficits and Neuroinflammation in Aged Rats: The Role of CX3CL1-CX3CR1 Signaling. / 01.08.2018 / PubMed / Full text
• Repopulating retinal microglia restore endogenous organization and function under CX3CL1-CX3CR1 regulation. / 03.2018 / PubMed / Full text
• Cryopreserved whole blood for the quantification of monocyte, T-cell and NK-cell subsets, and monocyte receptor expression by multi-color flow cytometry: A methodological study based on participants from the canadian longitudinal study on aging. / 05.2018 / PubMed / Full text
• Microglia and Aging: The Role of the TREM2-DAP12 and CX3CL1-CX3CR1 Axes. / 22.01.2018 / PubMed / Full text
• Strain specificities in age-related changes in mechanisms promoting and controlling rat spinal cord damage in experimental autoimmune encephalomyelitis. / 01.2018 / PubMed / Full text
• Sex as a determinant of age-related changes in rat spinal cord inflammation-oxidation state. / 10.2017 / PubMed / Full text
• Human Monocyte Subsets Are Transcriptionally and Functionally Altered in Aging in Response to Pattern Recognition Receptor Agonists. / 15.08.2017 / PubMed / Full text
• Transcriptomic analysis of purified human cortical microglia reveals age-associated changes. / 08.2017 / PubMed / Full text
• Phenotypic characteristics of aged CD4 CD28 T lymphocytes are determined by changes in the whole-genome DNA methylation pattern. / 04.2017 / PubMed / Full text
• Age exacerbates the CCR2/5-mediated neuroinflammatory response to traumatic brain injury. / 18.04.2016 / PubMed / Full text
• Alterations in Monocyte Phenotypes and Functions after a Hip Fracture in Elderly Individuals: A 6-Month Longitudinal Study. / 2016 / PubMed / Full text
• Microglia constitute a barrier that prevents neurotoxic protofibrillar Aβ42 hotspots around plaques. / 29.01.2015 / PubMed / Full text
• Alterations to the frequency and function of peripheral blood monocytes and associations with chronic disease in the advanced-age, frail elderly. / 2014 / PubMed / Full text

ECD

• Outcome of Descemet Membrane Endothelial Keratoplasty Using Corneas from Donors ≥80 Years of Age. / 03.2020 / PubMed / Full text
• The occurrence and dynamics of polychlorinated hydrocarbons in roe deer ([i]Capreolus capreolus[/i]) in South-western Slovakia. / 2019 / PubMed / Full text
• Corneal thickness, endothelial cell density, and morphological and morphometric features of corneal endothelial cells in goats. / 10.2018 / PubMed / Full text
• Endothelial cell density and characterization of corneal endothelial cells in the Tawny Owl (Strix aluco) using specular microscopy. / 03.2019 / PubMed / Full text
• An autopsy case report: Differences in radiological images correlate with histology in Erdheim-Chester disease. / 06.2018 / PubMed / Full text
• Community-based trials of mobile solutions for the detection and management of cognitive decline. / 06.2017 / PubMed / Full text
• Evaluating age-related change in lip somatosensation using somatosensory evoked magnetic fields. / 2017 / PubMed / Full text
• A novel method for examining corneal endothelial cell morphology in infants. / 06.2017 / PubMed / Full text
• Analyses of Factors Affecting Endothelial Cell Density in an Eye Bank Corneal Donor Database. / 09.2016 / PubMed / Full text
• Morphological Abnormalities of Schlemm's Canal in Primary Open-Angle Glaucoma From the Aspect of Aging. / 02.2016 / PubMed / Full text
• [TEMPORAL ORDER DETERIORATION AND CIRCADIAN DISRUPTION WITH AGE]. / 2015 / PubMed
• Age-Dependent Changes of the Temporal Order--Causes and Treatment. / 2016 / PubMed / Full text
• Pathogenesis of endothelial cell dysfunction in chronic kidney disease: a retrospective and what the future may hold. / 06.2015 / PubMed / Full text
• Specular microscopy to determine corneal endothelial cell morphology and morphometry in chinchillas (Chinchilla lanigera) in vivo. / 01.2015 / PubMed / Full text
• Oncogene-induced senescence as a new mechanism of disease: the paradigm of erdheim-chester disease. / 2014 / PubMed / Full text
• Comparison of endothelial cell density of organ cultured corneas with cornea donor study. / 06.2014 / PubMed / Full text

HDAC1

• HDAC1 modulates OGG1-initiated oxidative DNA damage repair in the aging brain and Alzheimer's disease. / 18.05.2020 / PubMed / Full text
• Loss of genomic integrity induced by lysosphingolipid imbalance drives ageing in the heart. / 04.2019 / PubMed / Full text
• Re-exploring the core genes and modules in the human frontal cortex during chronological aging: insights from network-based analysis of transcriptomic studies. / 20.10.2018 / PubMed / Full text
• Acetylation of PGC1α by Histone Deacetylase 1 Downregulation Is Implicated in Radiation-Induced Senescence of Brain Endothelial Cells. / 16.05.2019 / PubMed / Full text
• Histone deacetylase 1 expression is inversely correlated with age in the short-lived fish Nothobranchius furzeri. / 09.2018 / PubMed / Full text
• Ablation of toll-like receptor 4 attenuates aging-induced myocardial remodeling and contractile dysfunction through NCoRI-HDAC1-mediated regulation of autophagy. / 06.2018 / PubMed / Full text
• Caloric restriction delays early phases of carcinogenesis via effects on the tissue microenvironment. / 30.05.2017 / PubMed / Full text
• Epigallocatechin gallate reverses cTnI-low expression-induced age-related heart diastolic dysfunction through histone acetylation modification. / 10.2017 / PubMed / Full text
• Emerging roles for histone deacetylases in age-related muscle atrophy. / 27.10.2016 / PubMed / Full text
• [i]Rpd3[/i] interacts with insulin signaling in [i]Drosophila[/i] longevity extension. / 14.11.2016 / PubMed / Full text
• Expression of non-secreted IL-4 is associated with HDAC inhibitor-induced cell death, histone acetylation and c-Jun regulation in human gamma/delta T-cells. / 04.10.2016 / PubMed / Full text
• The effects of Rpd3 on fly metabolism, health, and longevity. / 15.12.2016 / PubMed / Full text
• Parthenolide induces MITF-M downregulation and senescence in patient-derived MITF-M(high) melanoma cell populations. / 23.02.2016 / PubMed / Full text
• Scopoletin has a potential activity for anti-aging via autophagy in human lung fibroblasts. / 15.03.2015 / PubMed / Full text
• De-regulated expression of the BRG1 chromatin remodeling factor in bone marrow mesenchymal stromal cells induces senescence associated with the silencing of NANOG and changes in the levels of chromatin proteins. / 2015 / PubMed / Full text
• Lysine deacetylases regulate the heat shock response including the age-associated impairment of HSF1. / 10.04.2015 / PubMed / Full text

IL10

• The beneficial effect of physical exercise on inflammatory makers in older individuals. / 06.06.2020 / PubMed / Full text
• Astrocyte senescence may drive alterations in GFAPα, CDKN2A p14 , and TAU3 transcript expression and contribute to cognitive decline. / 10.2019 / PubMed / Full text
• Dietary Spray-Dried Porcine Plasma Prevents Cognitive Decline in Senescent Mice and Reduces Neuroinflammation and Oxidative Stress. / 01.02.2020 / PubMed / Full text
• Age-dependent hepatic alterations induced by a high-fat high-fructose diet. / 05.2019 / PubMed / Full text
• [i]Lactobacillus paracasei[/i] PS23 decelerated age-related muscle loss by ensuring mitochondrial function in SAMP8 mice. / 29.01.2019 / PubMed / Full text
• Inflammatory cytokines and immune system modulation by aerobic versus resisted exercise training for elderly. / 03.2018 / PubMed / Full text
• Pentoxifylline, dexamethasone and azithromycin demonstrate distinct age-dependent and synergistic inhibition of TLR- and inflammasome-mediated cytokine production in human newborn and adult blood in vitro. / 2018 / PubMed / Full text
• Deficiency in Protein Tyrosine Phosphatase PTP1B Shortens Lifespan and Leads to Development of Acute Leukemia. / 01.01.2018 / PubMed / Full text
• The role of gender and labour status in immunosenescence of 65 Polish population. / 08.2017 / PubMed / Full text
• Serum Immune Mediators Independently Associate with Atherosclerosis in the Left (But Not Right) Carotid Territory of Older Individuals. / 12.2016 / PubMed / Full text
• IL10-driven STAT3 signalling in senescent macrophages promotes pathological eye angiogenesis. / 11.08.2015 / PubMed / Full text
• Development of depressive symptoms post hip fracture is associated with altered immunosuppressive phenotype in regulatory T and B lymphocytes. / 02.2016 / PubMed / Full text
• LIPID PROFILE AND CYTOKINES INTERACTIONS DURING SUCCESSFUL AGING. / 06.2015 / PubMed
• The effect of astaxanthin on the aging rat brain: gender-related differences in modulating inflammation. / 30.01.2016 / PubMed / Full text
• Candidate SNP associations of optimism and resilience in older adults: exploratory study of 935 community-dwelling adults. / 10.2014 / PubMed / Full text
• Oral delivery of glutamic acid decarboxylase (GAD)-65 and IL10 by Lactococcus lactis reverses diabetes in recent-onset NOD mice. / 08.2014 / PubMed / Full text

INS

• Melatonin protects INS-1 pancreatic β-cells from apoptosis and senescence induced by glucotoxicity and glucolipotoxicity. / 03.07.2020 / PubMed / Full text
• Nicotine triggers islet β cell senescence to facilitate the progression of type 2 diabetes. / 08.2020 / PubMed / Full text
• Reducing INS-IGF1 signaling protects against non-cell autonomous vesicle rupture caused by SNCA spreading. / 05.2020 / PubMed / Full text
• Insulin-like peptides and the mTOR-TFEB pathway protect [i]Caenorhabditis elegans[/i] hermaphrodites from mating-induced death. / 08.07.2019 / PubMed / Full text
• The Maghreb demographic transition: Tunisia case study. / 10-11.2018 / PubMed
• Temporal pattern of neuronal insulin release during Caenorhabditis elegans aging: Role of redox homeostasis. / 02.2019 / PubMed / Full text
• A functional study of all 40 [i]Caenorhabditis elegans[/i] insulin-like peptides. / 26.10.2018 / PubMed / Full text
• The anti-aging protein Klotho is induced by GABA therapy and exerts protective and stimulatory effects on pancreatic beta cells. / 02.12.2017 / PubMed / Full text
• Increase of Calcium Sensing Receptor Expression Is Related to Compensatory Insulin Secretion during Aging in Mice. / 2016 / PubMed / Full text
• Food-derived sensory cues modulate longevity via distinct neuroendocrine insulin-like peptides. / 01.05.2016 / PubMed / Full text
• Resveratrol attenuates senescence of adipose-derived mesenchymal stem cells and restores their paracrine effects on promoting insulin secretion of INS-1 cells through Pim-1. / 2016 / PubMed
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