Публикации о генах и старении (titles)
A2M
Age-Dependent Variation in Glycosylation Features of Alpha-2-Macroglobulin.
AACS
Sex differences in subjective age-associated changes in sleep: a prospective elderly cohort study.
ABCG2
Contribution of senescence in human endometrial stromal cells during proliferative phase to embryo receptivity†.
ABCG2 rs2231142 variant in hyperuricemia is modified by SLC2A9 and SLC22A12 polymorphisms and cardiovascular risk factors in an elderly community-dwelling population.
MeSH Terms
- ATP Binding Cassette Transporter, Subfamily G, Member 2
- Aged
- Aged, 80 and over
- Aging
- Cardiovascular Diseases
- China
- Cohort Studies
- Effect Modifier, Epidemiologic
- Epistasis, Genetic
- Female
- Genes, Modifier
- Genetic Predisposition to Disease
- Genome-Wide Association Study
- Glucose Transport Proteins, Facilitative
- Humans
- Hyperuricemia
- Independent Living
- Male
- Neoplasm Proteins
- Organic Anion Transporters
- Organic Cation Transport Proteins
- Polymorphism, Single Nucleotide
- Risk Factors
- Uric Acid
Keywords
- ABCG2
- Hypertension
- Polymorphisms
- Triglyceridemia
- Uric acid
ABL1
European LeukemiaNet 2020 recommendations for treating chronic myeloid leukemia.
MeSH Terms
- Aniline Compounds
- Antineoplastic Agents
- Clinical Decision-Making
- Consensus Development Conferences as Topic
- Dasatinib
- Disease Management
- Fusion Proteins, bcr-abl
- Gene Expression
- Humans
- Imatinib Mesylate
- Leukemia, Myelogenous, Chronic, BCR-ABL Positive
- Life Expectancy
- Monitoring, Physiologic
- Nitriles
- Protein Kinase Inhibitors
- Pyrimidines
- Quality of Life
- Quinolines
- Survival Analysis
ABO
Allelic distribution of [i]ABO[/i] gene in Chinese centenarians.
Genetically Determined ABO Blood Group and its Associations With Health and Disease.
MeSH Terms
- ABO Blood-Group System
- Adult
- Age Factors
- Aged
- Cardiovascular Diseases
- Female
- Gene Frequency
- Genetic Predisposition to Disease
- Health Status
- Healthy Aging
- Humans
- Incidence
- Male
- Middle Aged
- Phenotype
- Polymorphism, Single Nucleotide
- Prevalence
- Risk Assessment
- Risk Factors
- United Kingdom
Keywords
- ABO
- aging
- blood
- genetics
- hypertension
- phenotype
ABR
[Hidden hearing loss and early identification].
Aging But Not Age-Related Hearing Loss Dominates the Decrease of Parvalbumin Immunoreactivity in the Primary Auditory Cortex of Mice.
Hearing loss through apoptosis of the spiral ganglion neurons in apolipoprotein E knockout mice fed with a western diet.
Effects of enriched endogenous omega-3 fatty acids on age-related hearing loss in mice.
MeSH Terms
- Aging
- Animals
- Body Weight
- Caenorhabditis elegans Proteins
- Cochlea
- Evoked Potentials, Auditory, Brain Stem
- Fatty Acid Desaturases
- Fatty Acids, Omega-3
- Male
- Mice
- Mice, Inbred C57BL
- Mice, Transgenic
- Neurons
- Presbycusis
- Spiral Ganglion
Keywords
- Age-related hearing loss
- C57BL/6 mouse
- Cochlea
- Omega-3 (n-3) fatty acids
Hearing impairment and associated morphological changes in pituitary adenylate cyclase activating polypeptide (PACAP)-deficient mice.
MeSH Terms
- Aging
- Animals
- Cochlea
- Evoked Potentials, Auditory, Brain Stem
- Genotype
- Hearing
- Hearing Loss
- Inflammation
- Male
- Mice
- Mice, Knockout
- Models, Animal
- Neovascularization, Pathologic
- Neurons
- Pituitary Adenylate Cyclase-Activating Polypeptide
- Proteome
- Proto-Oncogene Proteins c-fos
Global nurse/midwife workforce and reproductive health through social ecology lens.
MeSH Terms
- Adolescent
- Cross-Sectional Studies
- Employment
- Female
- Global Health
- Health Education
- Humans
- Income
- Life Expectancy
- Male
- Midwifery
- Pregnancy
- Reproductive Health
- Social Environment
- Socioeconomic Factors
- Workforce
Keywords
- global health
- nurse/midwife workforce
- reproductive health
- social ecology
ACD
Genetics of cognitive trajectory in Brazilians: 15 years of follow-up from the Bambuí-Epigen Cohort Study of Aging.
ACE
Elite swimmers possess shorter telomeres than recreationally active controls.
Coronavirus Disease-2019 Conundrum: RAS Blockade and Geriatric-Associated Neuropsychiatric Disorders.
Pregnancy Protects Hyperandrogenemic Female Rats From Postmenopausal Hypertension.
Heart failure is associated with accelerated age related metabolic bone disease.
Management of heart failure: an Italian national survey on fellows/specialists in geriatrics.
Angiotensin-Converting Enzyme (ACE) genetic variation and longevity in Peruvian older people: a cross-sectional study.
COVID-19 and chronological aging: senolytics and other anti-aging drugs for the treatment or prevention of corona virus infection?
MeSH Terms
- Age Factors
- Aged
- Aged, 80 and over
- Aging
- Angiotensin-Converting Enzyme 2
- Antiviral Agents
- Azithromycin
- Betacoronavirus
- COVID-19
- Coronavirus Infections
- Dipeptidyl Peptidase 4
- Humans
- Hydroxychloroquine
- Pandemics
- Peptidyl-Dipeptidase A
- Pneumonia, Viral
- Quercetin
- Receptors, Virus
- SARS-CoV-2
Keywords
- Azithromycin
- COVID-19
- Doxycycline
- Hydroxy-chloroquine
- Quercetin
- Rapamycin
- aging
- antibiotic
- corona virus
- drug repurposing
- prevention
- senescence
- senolytic drug therapy
- viral replication
[i]A[/i]ngiotensin Converting Enzyme Inhibitors [i]C[/i]ombined with [i]E[/i]xercise for Hypertensive [i]S[/i]eniors (The ACES Trial): Study Protocol of a Randomized Controlled Trial.
Vascular age.
MeSH Terms
- Adolescent
- Adult
- Aged
- Aging
- Angiotensin-Converting Enzyme Inhibitors
- Atherosclerosis
- Child
- Elasticity
- Humans
- Middle Aged
- Perindopril
- Pulse Wave Analysis
- Vascular Stiffness
- Young Adult
Keywords
- ACE inhibitors
- CT angiography
- atorvastatin
- dyslipidemia
- hypertension
- intima media thickness (IMT)
- perindopril
- pulse wave velocity (PWV)
- statins
- vascular age
ACE2
How Does SARS-CoV-2 Affect the Central Nervous System? A Working Hypothesis.
Bioinformatic characterization of angiotensin-converting enzyme 2, the entry receptor for SARS-CoV-2.
MeSH Terms
- Aging
- Angiotensin-Converting Enzyme 2
- Betacoronavirus
- Binding Sites
- COVID-19
- Carrier Proteins
- Computational Biology
- Coronavirus Infections
- Female
- Gene Expression Regulation, Enzymologic
- Gene Ontology
- Humans
- Interferons
- Lung
- Male
- Metalloproteases
- Neovascularization, Physiologic
- Organ Specificity
- Pandemics
- Peptidyl-Dipeptidase A
- Pneumonia, Viral
- Promoter Regions, Genetic
- RNA, Messenger
- Receptors, Virus
- Renin-Angiotensin System
- SARS-CoV-2
- Sex Characteristics
- Single-Cell Analysis
- Transcription Factors
- Transcription Initiation Site
- Virus Attachment
A mouse-adapted model of SARS-CoV-2 to test COVID-19 countermeasures.
MeSH Terms
- Aging
- Angiotensin-Converting Enzyme 2
- Animals
- Betacoronavirus
- COVID-19
- COVID-19 Vaccines
- Coronavirus Infections
- Disease Models, Animal
- Female
- Forkhead Transcription Factors
- Humans
- Interferon-alpha
- Interferons
- Interleukins
- Male
- Mice
- Mice, Inbred BALB C
- Mice, Transgenic
- Models, Molecular
- Pandemics
- Peptidyl-Dipeptidase A
- Pneumonia, Viral
- Receptors, Virus
- SARS-CoV-2
- Viral Vaccines
COVID-19 and Senotherapeutics: Any Role for the Naturally-occurring Dipeptide Carnosine?
The dual impact of ACE2 in COVID-19 and ironical actions in geriatrics and pediatrics with possible therapeutic solutions.
MeSH Terms
- Age Factors
- Aged
- Aged, 80 and over
- Angiotensin-Converting Enzyme 2
- Anti-Inflammatory Agents
- Betacoronavirus
- COVID-19
- Child
- Child, Preschool
- Coronavirus
- Coronavirus Infections
- Female
- Geriatrics
- Humans
- Infant
- Infant, Newborn
- Male
- Pandemics
- Pediatrics
- Peptidyl-Dipeptidase A
- Pneumonia, Viral
- Protein Binding
- Receptors, Virus
- Renin-Angiotensin System
- SARS-CoV-2
- Severe Acute Respiratory Syndrome
- Virus Internalization
Keywords
- ACE2
- Angiotensin 2
- Angiotensin-(1–7)
- Corona virus
- Glycoprotein spikes
- RAAS system
The possible pathophysiology mechanism of cytokine storm in elderly adults with COVID-19 infection: the contribution of "inflame-aging".
MeSH Terms
- Adipocytes
- Age Factors
- Aged
- Aging
- Angiotensin II Type 2 Receptor Blockers
- Autophagy
- Betacoronavirus
- COVID-19
- Cellular Senescence
- Coronavirus Infections
- Cytokine Release Syndrome
- Cytokines
- Humans
- Immune System
- Inflammation
- Pandemics
- Pneumonia, Viral
- Reactive Oxygen Species
- Receptor, Angiotensin, Type 2
- SARS-CoV-2
- Vitamin D
- Vitamin D Deficiency
Keywords
- ACE2 receptor
- Autophagy
- COVID-19
- Cytokine storm
- Senescent cell
- Vitamin D
Decoding SARS-CoV-2 hijacking of host mitochondria in COVID-19 pathogenesis.
MeSH Terms
- Adaptive Immunity
- Angiotensin-Converting Enzyme 2
- Animals
- Betacoronavirus
- COVID-19
- Coronavirus Infections
- DNA, Mitochondrial
- Gene Expression Regulation, Viral
- Host Microbial Interactions
- Humans
- Immunity, Innate
- Mitochondria
- Pandemics
- Peptidyl-Dipeptidase A
- Pneumonia, Viral
- RNA, Viral
- SARS-CoV-2
- Virus Replication
Keywords
- COVID-19
- SARS-CoV
- aging
- coronavirus
- mitochondria
- mitochondrial DNA
A Mouse Model of SARS-CoV-2 Infection and Pathogenesis.
MeSH Terms
- Aging
- Angiotensin-Converting Enzyme 2
- Animals
- Betacoronavirus
- Brain
- COVID-19
- CRISPR-Cas Systems
- Coronavirus Infections
- Cytokines
- Disease Models, Animal
- Gene Knock-In Techniques
- Lung
- Lung Diseases, Interstitial
- Mice, Inbred C57BL
- Nose
- Pandemics
- Peptidyl-Dipeptidase A
- Pneumonia, Viral
- RNA, Viral
- SARS-CoV-2
- Stomach
- Trachea
- Viral Load
- Virus Replication
Keywords
- SARS-CoV-2
- angiotensin-converting enzyme II
- hACE2-KI/NIFDC
- mouse model
- pathogenesis
COVID-19-associated cardiovascular morbidity in older adults: a position paper from the Italian Society of Cardiovascular Researches.
Gut microbiota and Covid-19- possible link and implications.
MeSH Terms
- Aging
- Betacoronavirus
- COVID-19
- Coronavirus Infections
- Diet
- Dysbiosis
- Gastrointestinal Microbiome
- Gastrointestinal Tract
- Homeostasis
- Humans
- Immunity
- Lung
- Pandemics
- Pneumonia, Viral
- SARS-CoV-2
Keywords
- Covid-19
- Diet
- Dysbiosis
- Gut microbiome
- Immunity
- Lung microbiota
- SARS-CoV-2
Inflamm-aging: Why older men are the most susceptible to SARS-CoV-2 complicated outcomes.
MeSH Terms
- Aged
- Aged, 80 and over
- Aging
- Angiotensin-Converting Enzyme 2
- Antibodies, Monoclonal, Humanized
- Betacoronavirus
- COVID-19
- Comorbidity
- Coronavirus Infections
- Female
- Humans
- Inflammation
- Interferon Type I
- Interleukin-6
- Male
- Pandemics
- Peptidyl-Dipeptidase A
- Pneumonia, Viral
- SARS-CoV-2
- Severe Acute Respiratory Syndrome
Keywords
- COVID-19
- Cardiovascular diseases
- Host-directed therapies
- Inflamm-aging
- SARS-CoV-2
- interleukin-6
Restoration of the Renin-Angiotensin System Balance Is a Part of the Effect of Fasting on Cardiovascular Rejuvenation: Role of Age and Fasting Models.
Angiotensin 1-7 alleviates aging-associated muscle weakness and bone loss, but is not associated with accelerated aging in ACE2-knockout mice.
MeSH Terms
- Adipose Tissue
- Aging
- Angiotensin I
- Angiotensin-Converting Enzyme 2
- Animals
- Body Weight
- Bone Resorption
- Cyclin-Dependent Kinase Inhibitor p16
- Forelimb
- Gene Deletion
- Hand Strength
- Male
- Mice, Inbred C57BL
- Mice, Knockout
- Muscle Weakness
- Muscles
- Organ Size
- PAX3 Transcription Factor
- Peptide Fragments
- Peptidyl-Dipeptidase A
- Proto-Oncogene Proteins
- Receptors, G-Protein-Coupled
- Renin-Angiotensin System
- Time Factors
Keywords
- Angiotensin 1-7
- Angiotensin Converting Enzyme 2
- Mas receptor
- Muscle weakness
- osteoporosis
ACLY
In S. cerevisiae hydroxycitric acid antagonizes chronological aging and apoptosis regardless of citrate lyase.
ACR
Progenitor cell niche senescence reflects pathology of the parotid salivary gland in primary Sjögren's syndrome.
Jumping Joints: The Complex Relationship Between Osteoarthritis and Jumping Mechanography.
ACVR1
Fibrodysplasia Ossificans Progressiva (FOP): A Segmental Progeroid Syndrome.
ADA
Adenosine Metabolism in the Cerebral Cortex from Several Mice Models during Aging.
ADAM10
NKG2D Ligand Shedding in Response to Stress: Role of ADAM10.
Chronic Mild Stress Modified Epigenetic Mechanisms Leading to Accelerated Senescence and Impaired Cognitive Performance in Mice.
MeSH Terms
- ADAM10 Protein
- Aging
- Amyloid Precursor Protein Secretases
- Animals
- Cognition
- Epigenesis, Genetic
- Female
- Glial Fibrillary Acidic Protein
- Glycogen Synthase Kinase 3 beta
- Mechanistic Target of Rapamycin Complex 1
- Membrane Proteins
- Mice
- MicroRNAs
- NF-kappa B
- Reactive Oxygen Species
- Signal Transduction
- Stress, Psychological
Keywords
- Alzheimer’s disease
- SAMP8
- SAMR1
- age-related cognitive decline
- autophagy
- cognition
- epigenetics
- inflammation
- oxidative stress
- senescence
- stress
ADAM17
ACE2/ADAM17/TMPRSS2 Interplay May Be the Main Risk Factor for COVID-19.
MeSH Terms
- ADAM17 Protein
- Aged
- Aging
- Angiotensin-Converting Enzyme 2
- Betacoronavirus
- COVID-19
- Comorbidity
- Coronavirus Infections
- Female
- Humans
- Male
- Pandemics
- Peptidyl-Dipeptidase A
- Pneumonia, Viral
- Receptors, Interleukin-6
- Risk Factors
- SARS-CoV-2
- Serine Endopeptidases
- Tumor Necrosis Factor-alpha
Keywords
- ACE2
- ADAM17
- COVID-19 pathophysiology
- SARS-CoV-2
- TMPRSS2
ADH5
Can Serum Nitrosoproteome Predict Longevity of Aged Women?
ADM
Assessment of age-related differences in decomposition-based quantitative EMG in the intrinsic hand muscles: A multivariate approach.
Evaluation of transcriptional levels of the natriuretic peptides, endothelin-1, adrenomedullin, their receptors and long non-coding RNAs in rat cardiac tissue as cardiovascular biomarkers of aging.
ADORA2B
Adenosine A2B receptor: A pathogenic factor and a therapeutic target for sensorineural hearing loss.
ADRA2A
α2A-Adrenergic Receptor Inhibits the Progression of Cervical Cancer Through Blocking PI3K/AKT/mTOR Pathway.
AFM
Photocatalytic aging process of Nano-TiO coated polypropylene microplastics: Combining atomic force microscopy and infrared spectroscopy (AFM-IR) for nanoscale chemical characterization.
Nanoscale infrared, thermal and mechanical properties of aged microplastics revealed by an atomic force microscopy coupled with infrared spectroscopy (AFM-IR) technique.
Detecting zeta potential of polydimethylsiloxane (PDMS) in electrolyte solutions with atomic force microscope.
Recent Applications of Advanced Atomic Force Microscopy in Polymer Science: A Review.
Active fractions of mannoproteins derived from yeast cell wall stimulate innate and acquired immunity of adult and elderly dogs.
Keywords
- AFM, active fraction of mannoproteins
- ALP, alkaline phosphatase
- ALT, alanine aminotransferase
- Ageing
- CBC, complete blood count
- CD21+, B lymphocyte
- CD4+, auxiliary T lymphocyte
- CD5+, total T lymphocyte
- CD8+, cytotoxic lymphocyte
- CO, cells only
- Canine
- DCHT, delayed cutaneous hypersensitivity test
- FOSs, fructooligosaccharides
- GALT, gut-associated lymphoid tissue
- IL-12, interleukin 12
- IgA, immunoglobulin A
- Immunosenescence
- LPS, bacterial lipopolysaccharide
- MOSs, mannanoligosaccharides
- NADPH, reduced nicotinamide adenine dinucleotide phosphate
- NO, nitrogen monoxide
- NOS, nitric oxide synthase
- OD, optical density
- PMA, phorbol myristate acetate
- Saccharomyces cerevisiae
- Senescence
- TNF-α, tumour necrosis factor alpha
- Th1, helper T lymphocyte
The Effect of Waste Engine Oil and Waste Polyethylene on UV Aging Resistance of Asphalt.
Mechanical properties measured by atomic force microscopy define health biomarkers in ageing C. elegans.
MeSH Terms
- Aging
- Animal Feed
- Animals
- Bacillus subtilis
- Biomarkers
- Caenorhabditis elegans
- Caenorhabditis elegans Proteins
- Comamonas
- Escherichia coli
- Forkhead Transcription Factors
- Hot Temperature
- Insulin
- Microbiota
- Microscopy, Atomic Force
- Mutation
- Receptor, Insulin
- Signal Transduction
- Ultraviolet Rays
Nanomechanical insights: Amyloid beta oligomer-induced senescent brain endothelial cells.
MeSH Terms
- Alzheimer Disease
- Amyloid beta-Peptides
- Biomechanical Phenomena
- Brain
- Cell Culture Techniques
- Cell Membrane
- Cellular Senescence
- Endothelial Cells
- Endothelium, Vascular
- Humans
- Microscopy, Atomic Force
- Vascular Endothelial Growth Factor A
Keywords
- Amyloid beta oligomer
- Atomic force microscopy
- Brain endothelial cells
- Nanoindentation
- Nanomechanical properties
- Senescence
AGER
Vitamin D3 regulates apoptosis and proliferation in the testis of D-galactose-induced aged rat model.
AGT
SQSTM1/p62 and PPARGC1A/PGC-1alpha at the interface of autophagy and vascular senescence.
AHR
Indoles from the commensal microbiota act via the AHR and IL-10 to tune the cellular composition of the colonic epithelium during aging.
MeSH Terms
- Aging
- Animals
- Bacteria
- Cell Differentiation
- Epithelial Cells
- Female
- Goblet Cells
- Indoles
- Interleukin-10
- Interleukins
- Male
- Mice
- Mice, Inbred BALB C
- Mice, Inbred C57BL
- Mice, Knockout
- Microbiota
- Mucus
- Receptors, Aryl Hydrocarbon
- Signal Transduction
Keywords
- aging
- goblet cell
- intestinal homeostasis
- mucus
Role of the Aryl Hydrocarbon Receptor in Environmentally Induced Skin Aging and Skin Carcinogenesis.
MeSH Terms
- Animals
- Environmental Exposure
- Extracellular Matrix
- Humans
- Receptors, Aryl Hydrocarbon
- Skin Aging
- Skin Neoplasms
Keywords
- DNA damage
- UV radiation
- extracellular matrix
- extrinsic skin aging
- melanoma
- particulate matter
- pigmentation
- polycyclic aromatic hydrocarbons
- squamous cell carcinoma
AIP
[Aryl hydrocarbon receptor interacting protein (AIP) in human dermis during aging.]
Sex-Specific Association between Serum Vitamin D Status and Lipid Profiles: A Cross-Sectional Study of a Middle-Aged and Elderly Chinese Population.
The oblique effect: The relationship between profiles of visuospatial preference, cognition, and brain connectomics in older adults.
MeSH Terms
- Aged
- Brain
- Cognition
- Connectome
- Diffusion Tensor Imaging
- Executive Function
- Female
- Humans
- Judgment
- Male
- Middle Aged
- Neuropsychological Tests
- Pattern Recognition, Visual
- Spatial Processing
Keywords
- Aging
- Executive function
- Oblique effect
- Perception
- Structural connectivity
- Visuospatial processing
ALAS1
Heterozygous disruption of ALAS1 in mice causes an accelerated age-dependent reduction in free heme, but not total heme, in skeletal muscle and liver.
ALB
Effects of Age on Inflammatory Profiles and Nutrition/Energy Metabolism in Domestic Cats.
ALK
Catalog of Lung Cancer Gene Mutations Among Chinese Patients.
ALKBH8
Loss of epitranscriptomic control of selenocysteine utilization engages senescence and mitochondrial reprogramming .
MeSH Terms
- AlkB Homolog 8, tRNA Methyltransferase
- Animals
- Cells, Cultured
- Cellular Senescence
- Epigenesis, Genetic
- Gene Deletion
- Gene Expression Profiling
- Humans
- Mice
- Mitochondria
- Oxygen Consumption
- Selenocysteine
- Uncoupling Protein 2
Keywords
- Epitranscriptome
- Mitochondria
- Selenium
- Senescence
- Uncoupling protein
ALOX12
Arachidonate 12-lipoxygenase and 12-hydroxyeicosatetraenoic acid contribute to stromal aging-induced progression of pancreatic cancer.
ALOX5
Functional Characterization of Knock-In Mice Expressing a 12/15-Lipoxygenating Alox5 Mutant Instead of the 5-Lipoxygenating Wild-Type Enzyme.
AMH
Beyond premature ovarian insufficiency: Staging reproductive aging in adolescent and young adult cancer survivors.
Correlates and Timing of Reproductive Aging Transitions in a Global Cohort of Midlife Women With Human Immunodeficiency Virus: Insights From the REPRIEVE Trial.
Epigenetic clock measuring age acceleration via DNA methylation levels in blood is associated with decreased oocyte yield.
Modeling Variation in the Reproductive Lifespan of Female Adolescent and Young Adult Cancer Survivors Using AMH.
Improving Prediction of Age at Menopause Using Multiple Anti-Müllerian Hormone Measurements: the Tehran Lipid-Glucose Study.
Antimullerian Hormone and Impending Menopause in Late Reproductive Age: The Study of Women's Health Across the Nation.
Basal characterization and in vitro differentiation of putative stem cells derived from the adult mouse ovary.
Serum anti-Müllerian hormone concentration and follicle density throughout reproductive life and in different diseases-implications in fertility preservation.
MeSH Terms
- Adolescent
- Adult
- Aging
- Anti-Mullerian Hormone
- Child
- Child, Preschool
- Female
- Fertility Preservation
- Humans
- Ovarian Follicle
- Retrospective Studies
- Young Adult
Keywords
- anti-Müllerian hormone
- cancer
- fertility preservation
- ovarian reserve
- ovarian tissue
- primary follicle
- primordial follicle
Associations Between Anti-Mullerian Hormone and Cardiometabolic Health in Reproductive Age Women Are Explained by Body Mass Index.
MeSH Terms
- Adult
- Anti-Mullerian Hormone
- Biomarkers
- Body Mass Index
- Cardiovascular Diseases
- Case-Control Studies
- Cross-Sectional Studies
- Female
- Follow-Up Studies
- Humans
- Incidence
- Infertility, Female
- Polycystic Ovary Syndrome
- Prognosis
- United States
Keywords
- anti-mullerian hormone (AMH)
- cardiometabolic health
- cardiovascular risk
- ovarian aging
- ovarian reserve markers
- reproductive aging
Relationships between antral follicle count, blood serum concentration of anti-Müllerian hormone and fertility in mares.
MeSH Terms
- Aging
- Animals
- Anti-Mullerian Hormone
- Female
- Fertility
- Horses
- Ovarian Follicle
- Ovulation
Keywords
- AMH
- Anzahl Follikel
- Ovar
- Pferd
- Ultraschall
- compte folliculaire
- conta dei follicoli
- ecografia
- equine
- equini
- follicle count
- ovaia
- ovaire
- ovary
- reproductive status
- stato riproduttivo
- ultrasonography
- Reproduktionsstatus
- échographie
- équin
- état reproducteur
AMT
A multi-method comparison of autobiographical memory impairments amongst younger and older adults.
ANGPTL2
Circulating angiopoietin-like protein 2 levels and mortality risk in patients receiving maintenance hemodialysis: a prospective cohort study.
MeSH Terms
- Aged
- Angiopoietin-like Proteins
- Biomarkers
- C-Reactive Protein
- Disease Progression
- Female
- Humans
- Kidney Diseases
- Male
- Middle Aged
- Prognosis
- Prospective Studies
- Renal Dialysis
- Risk Factors
- Survival Rate
Keywords
- aging
- angiopoietin-like protein (ANGPTL) 2
- chronic inflammation
- hemodialysis
- mortality risk
ANK3
Age-related atrophy of cortical thickness and genetic effect of ANK3 gene in first episode MDD patients.
AOX1
N1-Methylnicotinamide: An Anti-Ovarian Aging Hormetin?
AP2B1
Circular RNA NF1-419 enhances autophagy to ameliorate senile dementia by binding Dynamin-1 and Adaptor protein 2 B1 in AD-like mice.
APC
Differences between blacks and whites in well-being, beliefs, emotional states, behaviors and survival, 1978-2014.
Wnt-induced, TRP53-mediated Cell Cycle Arrest of Precursors Underlies Interstitial Cell of Cajal Depletion During Aging.
Burden of musculoskeletal disorders in Iran during 1990-2017: estimates from the Global Burden of Disease Study 2017.
Fall-related mortality trends in older Japanese adults aged ≥65 years: a nationwide observational study.
Stroke Mortality Rates and Trends in Romania, 1994-2017.
MeSH Terms
- Adult
- Age Distribution
- Aged
- Aged, 80 and over
- Cause of Death
- Female
- Humans
- Life Expectancy
- Male
- Middle Aged
- Prognosis
- Registries
- Risk Assessment
- Risk Factors
- Romania
- Sex Distribution
- Stroke
- Time Factors
Keywords
- Mortality
- age-standardized mortality rates
- life expectancy
- stroke
A new approach to quantifying the EEG during walking: Initial evidence of gait related potentials and their changes with aging and dual tasking.
APOC3
Positional Obstructive Sleep Apnea Syndrome in Elderly Patients.
APOE
Polygenic risk score of longevity predicts longer survival across an age-continuum.
Association Between APOE Alleles and Change of Neuropsychological Tests in the Long Life Family Study.
The APOE gene cluster responds to air pollution factors in mice with coordinated expression of genes that differs by age in humans.
Homozygosity in the [i]APOE[/i] 3 Polymorphism Is Associated With Less Depression and Higher Serum Low-Density Lipoprotein in Chinese Elderly Schizophrenics.
Effect of apolipoprotein E polymorphism on cognition and brain in the Cambridge Centre for Ageing and Neuroscience cohort.
Cardiovascular risk factors and APOE-ε4 status affect memory functioning in aging via changes to temporal stem diffusion.
APOE [i]ε[/i]4 and resting-state functional connectivity in racially/ethnically diverse older adults.
Predictors of Olfactory Decline in Aging: A Longitudinal Population-Based Study.
When Culture Influences Genes: Positive Age Beliefs Amplify the Cognitive-Aging Benefit of APOE ε2.
Age and the association between apolipoprotein E genotype and Alzheimer disease: A cerebrospinal fluid biomarker-based case-control study.
Estimating the potential for dementia prevention through modifiable risk factors elimination in the real-world setting: a population-based study.
Machine learning-based estimation of cognitive performance using regional brain MRI markers: the Northern Manhattan Study.
Effects of an APOE Promoter Polymorphism on Fronto-Parietal Functional Connectivity During Nondemented Aging.
The relationship of parental longevity with the aging brain-results from UK Biobank.
Alzheimer's Patient Microglia Exhibit Enhanced Aging and Unique Transcriptional Activation.
Relationships Between Plasma Lipids Species, Gender, Risk Factors, and Alzheimer's Disease.
Effects of sex, age, and apolipoprotein E genotype on hippocampal parenchymal fraction in cognitively normal older adults.
MeSH Terms
- Age Factors
- Aged
- Aged, 80 and over
- Apolipoproteins E
- Biomarkers
- Cognition
- Databases, Factual
- Female
- Genotype
- Hippocampus
- Humans
- Linear Models
- Male
- Middle Aged
- Neuroimaging
- Organ Size
- Parenchymal Tissue
- Reference Values
- Sex Factors
Keywords
- Alzheimer’s disease
- Apolipoprotein E ϵ4
- Atrophy
- Brain
- Healthy aging
- Hippocampal parenchymal fraction
- Hippocampal volumetric integrity
- Hippocampus
- MRI
- Mild cognitive impairment
- Neurodegeneration
- Sex
Cognitive Health of Nonagenarians in Southern Italy: A Descriptive Analysis from a Cross-Sectional, Home-Based Pilot Study of Exceptional Longevity (Cilento Initiative on Aging Outcomes Or CIAO).
Apolipoprotein E and Health in Older Men: The Concord Health and Ageing in Men Project.
CSF amyloid is a consistent predictor of white matter hyperintensities across the disease course from aging to Alzheimer's disease.
MeSH Terms
- Aged
- Aged, 80 and over
- Aging
- Alzheimer Disease
- Amyloid beta-Peptides
- Biomarkers
- Cerebrovascular Disorders
- Cognitive Dysfunction
- Female
- Humans
- Magnetic Resonance Imaging
- Male
- Peptide Fragments
- White Matter
- tau Proteins
Keywords
- Alzheimer's disease
- Amyloid
- Cerebrospinal fluid
- Tau
- Vascular disease
- White matter hyperintensities
Association of Cardiovascular Risk Factors with Cerebral Perfusion in Whites and African Americans.
Alzheimer's Risk Factors Age, APOE Genotype, and Sex Drive Distinct Molecular Pathways.
MeSH Terms
- Adaptor Proteins, Signal Transducing
- Age Factors
- Aging
- Alzheimer Disease
- Animals
- Apolipoprotein E2
- Apolipoprotein E3
- Apolipoprotein E4
- Apolipoproteins E
- Brain
- Female
- Gene Expression
- Gene Expression Profiling
- Gene Regulatory Networks
- Genotype
- Humans
- Male
- Membrane Glycoproteins
- Membrane Proteins
- Metabolome
- Mice
- Mice, Transgenic
- Protective Factors
- Receptors, Immunologic
- Risk Factors
- Serpins
- Sex Factors
- Unfolded Protein Response
Keywords
- APOE
- Alzheimer’s disease
- Serpina3
- age
- extracellular vesicles
- inflammation
- lipid metabolism
- metabolomics
- sex
- transcriptomics
Less agreeable, better preserved? A PET amyloid and MRI study in a community-based cohort.
MeSH Terms
- Aged
- Aged, 80 and over
- Amyloidogenic Proteins
- Apolipoproteins E
- Brain
- Cognition
- Cohort Studies
- Female
- Follow-Up Studies
- Humans
- Magnetic Resonance Imaging
- Male
- Neuroimaging
- Organ Size
- Personality
- Positron-Emission Tomography
Keywords
- Amyloid load
- Cognitive aging
- Cohort studies
- Personality
- Structural MRI
Physical Activity as Moderator of the Association Between APOE and Cognitive Decline in Older Adults: Results from Three Longitudinal Cohort Studies.
Longitudinal Maintenance of Cognitive Health in Centenarians in the 100-plus Study.
Interaction of APOE, cerebral blood flow, and cortical thickness in the entorhinal cortex predicts memory decline.
Determinants of mesial temporal lobe volume loss in older individuals with preserved cognition: a longitudinal PET amyloid study.
MeSH Terms
- Aged
- Aged, 80 and over
- Aging
- Alleles
- Amyloidogenic Proteins
- Apolipoprotein E4
- Cognitive Reserve
- Female
- Follow-Up Studies
- Genotype
- Humans
- Longitudinal Studies
- Male
- Neuropsychological Tests
- Organ Size
- Positron-Emission Tomography
- Sex Factors
- Temporal Lobe
Keywords
- APOE
- Amyloid load
- Cognitive changes
- Mesial temporal lobe
- Normal aging
- Structural MRI
Long-term exposure to ambient air pollution, APOE-ε4 status, and cognitive decline in a cohort of older adults in northern Manhattan.
APOE region molecular signatures of Alzheimer's disease across races/ethnicities.
MeSH Terms
- Alleles
- Alzheimer Disease
- Apolipoproteins E
- Continental Population Groups
- Haplotypes
- Heterozygote
- Homozygote
- Humans
- Linkage Disequilibrium
- Polymorphism, Single Nucleotide
- Risk Factors
Keywords
- APOE polymorphism
- Aging
- Alzheimer's disease
- Health span
- Life span
- Neurodegenerative disorders
Varying Effects of APOE Alleles on Extreme Longevity in European Ethnicities.
Prospective Evaluation of Cognitive Health and Related Factors in Elderly at Risk for Developing Alzheimer's Dementia: A Longitudinal Cohort Study.
MeSH Terms
- Aged
- Aged, 80 and over
- Alzheimer Disease
- Anxiety
- Apolipoprotein E4
- Cognition
- Cognitive Dysfunction
- Cohort Studies
- Depression
- Efficiency
- Female
- Healthy Volunteers
- Humans
- Longitudinal Studies
- Male
- Mental Status and Dementia Tests
- Middle Aged
- Neuropsychological Tests
- Prospective Studies
- Risk Factors
- Sleep
- United Kingdom
- Work
Keywords
- Alzheimer Disease
- CHARIOT
- aging registry
- cognitive health
- pre-clinical
Association of Cardiovascular and Alzheimer's Disease Risk Factors with Intracranial Arterial Blood Flow in Whites and African Americans.
MeSH Terms
- African Americans
- Aged
- Alzheimer Disease
- Biomarkers
- Blood Flow Velocity
- Cardiovascular Diseases
- Cerebrovascular Circulation
- European Continental Ancestry Group
- Female
- Humans
- Male
- Middle Aged
- Risk Factors
Keywords
- African Americans
- Alzheimer’s disease
- Apolipoprotein E4
- aging
- cerebrovascular circulation
- glucose
- metabolic syndrome
- neuroimaging
- risk factors
Is Ongoing Anticholinergic Burden Associated With Greater Cognitive Decline and Dementia Severity in Mild to Moderate Alzheimer's Disease?
Multicenter Alzheimer's and Parkinson's disease immune biomarker verification study.
MeSH Terms
- Age Factors
- Aged
- Aged, 80 and over
- Alzheimer Disease
- Amyloid
- Biomarkers
- Cohort Studies
- Europe
- Female
- Humans
- Inflammation
- Male
- Middle Aged
- Parkinson Disease
- Sex Factors
- tau Proteins
Keywords
- Aging
- Alzheimer's disease
- Amyloid
- Biomarker
- Cerebrospinal fluid
- Inflammation
- Mild cognitive impairment
- Multicenter
- Parkinson's disease
- Tau
Prospective Memory: Age related change is influenced by APOE genotype.
Education Moderates the Relation Between APOE ɛ4 and Memory in Nondemented Non-Hispanic Black Older Adults.
MeSH Terms
- Adult
- African Americans
- Aged
- Aged, 80 and over
- Aging
- Alzheimer Disease
- Apolipoprotein E4
- Cognitive Reserve
- Educational Status
- Executive Function
- Female
- Humans
- Male
- Memory
- Memory, Episodic
- Memory, Short-Term
- Middle Aged
- Neuropsychological Tests
- Sex Characteristics
Keywords
- APOE
- African American
- Alzheimer’s disease
- cognitive reserve
- educational attainment
- episodic memory
- genetic risk
- neuropsychological evaluation
Apolipoprotein E ε4 allele effects on longitudinal cognitive trajectories are sex and age dependent.
MeSH Terms
- Age Factors
- Aged
- Alleles
- Apolipoprotein E4
- Cognition Disorders
- European Continental Ancestry Group
- Executive Function
- Female
- Humans
- Longitudinal Studies
- Male
- Memory
- Neuropsychological Tests
- Sex Factors
Keywords
- Aging
- Alzheimer's disease
- Apolipoprotein E ε4
- Cognitive decline
- Sex
Interactive effect of age and APOE-ε4 allele load on white matter myelin content in cognitively normal middle-aged subjects.
APOE modifies the interaction of entorhinal cerebral blood flow and cortical thickness on memory function in cognitively normal older adults.
When time's arrow doesn't bend: APOE-ε4 influences episodic memory before old age.
Cognitive-Motor Integration Performance Is Affected by Sex, APOE Status, and Family History of Dementia.
MeSH Terms
- Aged
- Apolipoproteins E
- Cognition
- Cognitive Dysfunction
- Cross-Sectional Studies
- Dementia
- Female
- Humans
- Male
- Medical History Taking
- Middle Aged
- Photic Stimulation
- Psychomotor Performance
- Sex Characteristics
- Surveys and Questionnaires
Keywords
- Aging
- alzheimer’s disease
- apolipoprotein E4
- dementia risk
- geriatric
assessment
- motor skills
- movement
- visuomotor integration
Associations among amyloid status, age, and longitudinal regional brain atrophy in cognitively unimpaired older adults.
Cognitive function and neuropathological outcomes: a forward-looking approach.
APOE gene-dependent BOLD responses to a breath-hold across the adult lifespan.
MeSH Terms
- Adult
- Aged
- Aging
- Apolipoprotein E3
- Apolipoprotein E4
- Apolipoproteins E
- Breath Holding
- Cerebrovascular Circulation
- Cross-Over Studies
- Double-Blind Method
- Female
- Genotype
- Hemodynamics
- Humans
- Longevity
- Magnetic Resonance Imaging
- Male
- Middle Aged
- Nitrates
Keywords
- Ageing
- Alzheimer's disease
- Apolipoprotein E
- BOLD fMRI
- Breath-hold
- Cerebrovascular reactivity
APP
Pre-symptomatic Caspase-1 inhibitor delays cognitive decline in a mouse model of Alzheimer disease and aging.
MeSH Terms
- Aging
- Alzheimer Disease
- Amyloid beta-Peptides
- Animals
- Behavior, Animal
- Cognitive Dysfunction
- Cytokines
- Dipeptides
- Disease Models, Animal
- Encephalitis
- Female
- Humans
- Inflammation
- Male
- Memory Disorders
- Mice
- Mice, Inbred C57BL
- Mice, Transgenic
- Serpins
- Spatial Memory
- Viral Proteins
- para-Aminobenzoates
Regorafenib Regulates AD Pathology, Neuroinflammation, and Dendritic Spinogenesis in Cells and a Mouse Model of AD.
An agnostic reevaluation of the amyloid cascade hypothesis of Alzheimer's disease pathogenesis: The role of APP homeostasis.
Transcriptomic profiling of microglia and astrocytes throughout aging.
Platelets in Amyloidogenic Mice Are Activated and Invade the Brain.
CHIP modulates APP-induced autophagy-dependent pathological symptoms in Drosophila.
MeSH Terms
- Alzheimer Disease
- Amyloid beta-Protein Precursor
- Animals
- Aspartic Acid Endopeptidases
- Autophagy
- Brain
- Cognitive Dysfunction
- Disease Models, Animal
- Dopaminergic Neurons
- Down-Regulation
- Drosophila
- Drosophila Proteins
- Eye
- Learning Disabilities
- Locomotion
- Longevity
- Nuclear Proteins
- Presenilins
- RNA Interference
- Wings, Animal
Keywords
CHIP
- APP
- Alzheimer’s disease
- Aβ
- autophagy
Studies on APP metabolism related to age-associated mitochondrial dysfunction in APP/PS1 transgenic mice.
MeSH Terms
- Adenosine Triphosphate
- Aging
- Alzheimer Disease
- Amyloid beta-Protein Precursor
- Animals
- Blood Platelets
- Disease Models, Animal
- Hippocampus
- Mice
- Mice, Inbred C57BL
- Mice, Transgenic
- Mitochondria
- Presenilin-1
Keywords
- APP/PS1 mice
- Amyloid-beta
- adenosine 5’-triphosphate
- mitochondria dysfunction
- platelets
Intermittent Hypoxia-Hyperoxia Training Improves Cognitive Function and Decreases Circulating Biomarkers of Alzheimer's Disease in Patients with Mild Cognitive Impairment: A Pilot Study.
MeSH Terms
- Aged
- Alzheimer Disease
- Biomarkers
- Case-Control Studies
- Cognition
- Cognitive Dysfunction
- Female
- Humans
- Hyperoxia
- Hypoxia
- Male
- Middle Aged
- Pilot Projects
- Respiratory Therapy
- Treatment Outcome
Keywords
- Alzheimer’s disease
- adaptation
- aging
- amyloid beta
- biomarker
- cognitive function
- hyperoxia
- intermittent hypoxia
- platelets
The Implication of Androgens in the Presence of Protein Kinase C to Repair Alzheimer’s Disease-Induced Cognitive Dysfunction
MeSH Terms
- Adult
- Aged
- Aged, 80 and over
- Aging
- Alzheimer Disease
- Amyloid Precursor Protein Secretases
- Amyloid beta-Peptides
- Androgens
- Aspartic Acid Endopeptidases
- Cognition
- Cognitive Dysfunction
- Cyclic AMP Response Element-Binding Protein
- Female
- Hippocampus
- Humans
- Learning
- MAP Kinase Signaling System
- Male
- Middle Aged
- Neoplasm Proteins
- Phosphorylation
- Protein Kinase C
- Receptors for Activated C Kinase
- tau Proteins
Keywords
- Androgens
- Cognition
- Hippocampus
- Protein kinase C
- Spatial memory
Modulation of Neural and Muscular Adaptation Processes During Resistance Training by Fish Protein Ingestions in Older Adults.
Antipsychotic Polypharmacy in Older Adult Asian Patients With Schizophrenia: Research on Asian Psychotropic Prescription Pattern.
A pleiotropic role for exosomes loaded with the amyloid β precursor protein carboxyl-terminal fragments in the brain of Down syndrome patients.
APPL1
Insulin and adipokine signaling and their cross-regulation in postmortem human brain.
AQP3
Transbuccal platform for delivery of lipogenic actives to facial skin: Because fat matters.
AR
Mechanisms of Androgen Receptor Agonist- and Antagonist-Mediated Cellular Senescence in Prostate Cancer.
Interleukin-23 Represses the Level of Cell Senescence Induced by the Androgen Receptor Antagonists Enzalutamide and Darolutamide in Castration-Resistant Prostate Cancer Cells.
A Landscape of Murine Long Non-Coding RNAs Reveals the Leading Transcriptome Alterations in Adipose Tissue during Aging.
Senolytic compounds control a distinct fate of androgen receptor agonist- and antagonist-induced cellular senescent LNCaP prostate cancer cells.
Role of gut microbiota in sex- and diet-dependent metabolic disorders that lead to early mortality of androgen receptor-deficient male mice.
MeSH Terms
- Adipocytes
- Adipose Tissue
- Animals
- Anti-Bacterial Agents
- Diet
- Diet, High-Fat
- Feces
- Female
- Gastrointestinal Microbiome
- Lipid Metabolism
- Longevity
- Male
- Metabolic Diseases
- Mice
- Mice, Inbred C57BL
- Mice, Knockout
- Obesity
- Receptors, Androgen
- Sex Characteristics
Keywords
- androgen-insensitive syndrome
- longevity
- metabolic syndrome
- testosterone
- type 2 diabetes
A jaboticaba extract prevents prostatic damage associated with aging and high-fat diet intake.
Identifying blood-specific age-related DNA methylation markers on the Illumina MethylationEPIC® BeadChip.
MeSH Terms
- Adolescent
- Adult
- Aged
- Aged, 80 and over
- Aging
- Child
- Child, Preschool
- Cohort Studies
- CpG Islands
- DNA Methylation
- Forensic Genetics
- Genetic Markers
- Humans
- Infant
- Infant, Newborn
- Linear Models
- Middle Aged
- Oligonucleotide Array Sequence Analysis
- Young Adult
Keywords
- Age
- CpG sites
- DNA methylation
- Forensic age estimation
- Forensic epigenetics
- Illumina MethylationEPIC
ARC
The Polymorphism rs2968 of [i]LSS[/i] Gene Confers Susceptibility to Age-Related Cataract.
MeSH Terms
- Aged
- Aging
- Alleles
- Cataract
- Female
- Gene Expression Regulation
- Genetic Association Studies
- Genetic Predisposition to Disease
- Genotype
- Haplotypes
- Humans
- Hydroxymethylglutaryl CoA Reductases
- Intramolecular Transferases
- Lens, Crystalline
- Male
- Middle Aged
- Polymorphism, Single Nucleotide
Keywords
- ARC
- HMGCR
- LSS
- SNPs
- lanosterol
Decreased Anti-Müllerian hormone and Anti-Müllerian hormone receptor type 2 in hypothalami of old Japanese Black cows.
Resveratrol delay the cataract formation against naphthalene-induced experimental cataract in the albino rats.
AREG
Targeting amphiregulin (AREG) derived from senescent stromal cells diminishes cancer resistance and averts programmed cell death 1 ligand (PD-L1)-mediated immunosuppression.
MeSH Terms
- Amphiregulin
- Animals
- Antineoplastic Agents
- B7-H1 Antigen
- Cells, Cultured
- Cellular Senescence
- Drug Resistance, Neoplasm
- Humans
- Mice
- Mice, Inbred NOD
- Mice, SCID
- Stromal Cells
- Tumor Microenvironment
Keywords
- aging
- amphiregulin
- cancer resistance
- clinical biomarker
- combinational treatment
- programmed cell death 1 ligand
- senescence-associated secretory phenotype
- stroma
ARNT
Loss of ARNT in skeletal muscle limits muscle regeneration in aging.
[Arylhydrocarbon receptor nuclear translocator (ARNT) in human skin during aging.]
MeSH Terms
- Adolescent
- Adult
- Aged
- Aged, 80 and over
- Aging
- Aryl Hydrocarbon Receptor Nuclear Translocator
- Child
- Child, Preschool
- Dermis
- Fetus
- Fibroblasts
- Humans
- Infant
- Infant, Newborn
- Skin
- Skin Aging
- Young Adult
Keywords
- ARNT
- PCNA
- aging
- fibroblasts
- skin
The E3 ubiquitin ligase STUB1 attenuates cell senescence by promoting the ubiquitination and degradation of the core circadian regulator BMAL1.
ASB7
ASB7 Is a Novel Regulator of Cytoskeletal Organization During Oocyte Maturation.
ASL
Increased blood-brain barrier permeability to water in the aging brain detected using noninvasive multi-TE ASL MRI.
Quantitative Cerebrovascular Reactivity in Normal Aging: Comparison Between Phase-Contrast and Arterial Spin Labeling MRI.
Correcting Task fMRI Signals for Variability in Baseline CBF Improves BOLD-Behavior Relationships: A Feasibility Study in an Aging Model.
ASXL1
ASXL1 mutation in clonal hematopoiesis.
ATF4
Endoplasmic Reticulum Stress Mediates Vascular Smooth Muscle Cell Calcification via Increased Release of Grp78-Loaded Extracellular Vesicles.
ATF6
Cellular proteostasis decline in human senescence.
Impact of endoplasmic reticulum stress on oocyte aging mechanisms.
ER stress activates immunosuppressive network: implications for aging and Alzheimer's disease.
Towards Age-Related Anti-Inflammatory Therapy: Klotho Suppresses Activation of ER and Golgi Stress Response in Senescent Monocytes.
ATG3
Estrogen Signaling Induces Mitochondrial Dysfunction-Associated Autophagy and Senescence in Breast Cancer Cells.
ATG5
Autophagy and heat-shock response impair stress granule assembly during cellular senescence.
ATG7
Age-related impairment of autophagy in cervical motor neurons.
Comprehensive Bioinformatics Identifies Key microRNA Players in ATG7-Deficient Lung Fibroblasts.
Regulation of autophagy by DNA G-quadruplexes.
ATG7 is essential for secretion of iron from ameloblasts and normal growth of murine incisors during aging.
Enhancing Autophagy Diminishes Aberrant Ca Homeostasis and Arrhythmogenesis in Aging Rabbit Hearts.
ATM
ATM mediated-p53 signaling pathway forms a novel axis for senescence control.
Non-canonical ATM/MRN activities temporally define the senescence secretory program.
ATM is a key driver of NF-κB-dependent DNA-damage-induced senescence, stem cell dysfunction and aging.
ATM suppresses leaf senescence triggered by DNA double-strand break through epigenetic control of senescence-associated genes in Arabidopsis.
Glioblastoma Cells Do Not Affect Axitinib-Dependent Senescence of HUVECs in a Transwell Coculture Model.
Declining BRCA-Mediated DNA Repair in Sperm Aging and its Prevention by Sphingosine-1-Phosphate.
BRCA-related ATM-mediated DNA double-strand break repair and ovarian aging.
MeSH Terms
- Aging
- Animals
- Ataxia Telangiectasia
- BRCA1 Protein
- BRCA2 Protein
- DNA Breaks, Double-Stranded
- DNA Repair
- Female
- Fertility
- Fertility Preservation
- Humans
- Mice
- Oocytes
- Ovarian Follicle
- Ovarian Reserve
- Ovary
Keywords
BRCA
BRCA1/2
- DNA repair
- anti-Mullerian hormone
- chemotherapy
- mutations
- oocyte
- ovarian aging
- ovarian reserve
- ovarian response
ATM Deficiency Accelerates DNA Damage, Telomere Erosion, and Premature T Cell Aging in HIV-Infected Individuals on Antiretroviral Therapy.
SMG1 heterozygosity exacerbates haematopoietic cancer development in Atm null mice by increasing persistent DNA damage and oxidative stress.
MeSH Terms
- Animals
- Ataxia Telangiectasia Mutated Proteins
- Carcinogenesis
- Cells, Cultured
- DNA Damage
- Embryo, Mammalian
- Fibroblasts
- Gamma Rays
- Hematologic Neoplasms
- Heterozygote
- Kaplan-Meier Estimate
- Longevity
- Lymphoma
- Mice, Inbred C57BL
- Mice, Knockout
- Oxidative Stress
- Protein-Serine-Threonine Kinases
Keywords
- DNA damage
- cancer
- inflammation
- lymphoma
- oxidative stress
LncRNA RP11-670E13.6, interacted with hnRNPH, delays cellular senescence by sponging microRNA-663a in UVB damaged dermal fibroblasts.
Tel1/ATM Signaling to the Checkpoint Contributes to Replicative Senescence in the Absence of Telomerase.
MeSH Terms
- Amino Acid Substitution
- Ataxia Telangiectasia Mutated Proteins
- Cell Cycle Checkpoints
- Cell Division
- Cellular Senescence
- DNA Damage
- DNA Replication
- DNA, Single-Stranded
- DNA-Binding Proteins
- Intracellular Signaling Peptides and Proteins
- Mutant Proteins
- Protein-Serine-Threonine Kinases
- Saccharomyces cerevisiae
- Saccharomyces cerevisiae Proteins
- Telomerase
- Telomere
- Telomere Shortening
Keywords
- Tel1
- checkpoint
- replicative senescence
- telomere
ATP7A
Adipocyte-specific disruption of ATPase copper transporting α in mice accelerates lipoatrophy.
MeSH Terms
- 3T3-L1 Cells
- Adipocytes
- Adipose Tissue, White
- Aging
- Animals
- Body Weight
- Copper
- Copper-Transporting ATPases
- Diet, High-Fat
- Energy Metabolism
- Insulin Resistance
- Lipid Metabolism
- Lipodystrophy
- Lipolysis
- Mice
- Mice, Knockout
Keywords
- ATP7A
- Adipose tissues
- Copper
- Insulin resistance
- Lipoatrophy
ATR
Bloodstain age estimation through infrared spectroscopy and Chemometric models.
Artificial Intelligence and fourier-transform infrared spectroscopy for evaluating water-mediated degradation of lubricant oils.
Senescence Induction by Combined Ionizing Radiation and DNA Damage Response Inhibitors in Head and Neck Squamous Cell Carcinoma Cells.
Kinetics of thermal degradation and lifetime study of poly(vinylidene fluoride) (PVDF) subjected to bioethanol fuel accelerated aging.
Supraphysiological protection from replication stress does not extend mammalian lifespan.
Assessing the Retest Reliability of Prefrontal EEG Markers of Brain Rhythm Slowing in the Eyes-Closed Resting State.
Effects of Hydrogen Peroxide and Sodium Hypochlorite Aging on Properties and Performance of Polyethersulfone Ultrafiltration Membrane.
MeSH Terms
- Humic Substances
- Hydrogen Peroxide
- Hydrophobic and Hydrophilic Interactions
- Membranes, Artificial
- Polymers
- Sodium Hypochlorite
- Sulfones
- Ultrafiltration
Keywords
- chemical cleaning
- hydrogen peroxide (H2O2)
- membrane aging
- polyethersulfone (PES) ultrafiltration (UF) membrane
- sodium hypochlorite (NaClO)
NF-κB signaling in skin aging.
Development of a w/o emulsion using ionic liquid strategy for transdermal delivery of anti - aging component α - lipoic acid: Mechanism of different ionic liquids on skin retention and efficacy evaluation.
Effect of Nitrogen-Doped Graphene Oxide on the Aging Behavior of Nitrile-Butadiene Rubber.
AVP
Plasma oxytocin and vasopressin levels in young and older men and women: Functional relationships with attachment and cognition.
MeSH Terms
- Adolescent
- Adult
- Age Factors
- Aged
- Aged, 80 and over
- Aging
- Anxiety
- Avoidance Learning
- Cognition
- Cohort Studies
- Female
- Humans
- Male
- Middle Aged
- Object Attachment
- Oxytocin
- Sex Factors
- Vasopressins
- Young Adult
Keywords
- Age
- Attachment anxiety
- Oxytocin
- Processing speed
- Sex
- Vasopressin
B4GALT1
Expression of β-1,4-galactosyltransferases during Aging in Caenorhabditis elegans.
BACE1
Electric Stimulation of Neurogenesis Improves Behavioral Recovery After Focal Ischemia in Aged Rats.
Disruption of synaptic expression pattern and age-related DNA oxidation in a neuronal model of lead-induced toxicity.
BAD
I imidazoline receptor modulation protects aged SAMP8 mice against cognitive decline by suppressing the calcineurin pathway.
BAK1
Developmental Attenuation of Neuronal Apoptosis by Neural-Specific Splicing of Bak1 Microexon.
MeSH Terms
- Animals
- Apoptosis
- Brain
- Cell Line, Tumor
- Cells, Cultured
- Female
- Heterogeneous-Nuclear Ribonucleoproteins
- Male
- Mice
- Mice, Inbred C57BL
- Mutation
- Neural Stem Cells
- Neurogenesis
- Nonsense Mediated mRNA Decay
- Polypyrimidine Tract-Binding Protein
- RNA Splicing
- bcl-2 Homologous Antagonist-Killer Protein
Keywords
- AS-NMD
- BAK
- BCL2 family proteins
- NMD
- PTB
- PTBP
- PTBP2
- UPF2
- alternative splicing
- cell death
- neural development
- neurogenesis
- neuronal lifespan
BANF1
An additional case of Néstor-Guillermo progeria syndrome diagnosed in early childhood.
BATF
LncRNA-ES3 inhibition by Bhlhe40 is involved in high glucose-induced calcification/senescence of vascular smooth muscle cells.
BAX
Clearance of therapy-induced senescent tumor cells by the senolytic ABT-263 via interference with BCL-X -BAX interaction.
CREB Signaling Mediates Dose-Dependent Radiation Response in the Murine Hippocampus Two Years after Total Body Exposure.
BAZ2B
Two conserved epigenetic regulators prevent healthy ageing.
MeSH Terms
- Aging
- Animals
- Caenorhabditis elegans
- Caenorhabditis elegans Proteins
- Cognition
- Cognitive Dysfunction
- Epigenesis, Genetic
- Healthy Aging
- Histone-Lysine N-Methyltransferase
- Histones
- Humans
- Longevity
- Lysine
- Male
- Memory
- Methylation
- Mice
- Mitochondria
- Neurons
- Proteins
- RNA Interference
- Spatial Learning
- Transcription Factors, General
BCL6
Ecto-NTPDase CD39 is a negative checkpoint that inhibits follicular helper cell generation.
BCR
The presence of CLL-associated stereotypic B cell receptors in the normal BCR repertoire from healthy individuals increases with age.
BDNF
Influence of [i]BDNF[/i] Genetic Polymorphisms in the Pathophysiology of Aging-related Diseases.
Moderators of the Impact of (Poly)Phenols Interventions on Psychomotor Functions and BDNF: Insights from Subgroup Analysis and Meta-Regression.
Astroglia-Derived BDNF and MSK-1 Mediate Experience- and Diet-Dependent Synaptic Plasticity.
BDNF reverses aging-related microglial activation.
High Supervised Resistance Training in Elderly Women: The Role of Supervision Ratio.
Metformin regulates astrocyte reactivity in Parkinson's disease and normal aging.
Aging-Induced Brain-Derived Neurotrophic Factor in Adipocyte Progenitors Contributes to Adipose Tissue Dysfunction.
The Role of BDNF on Aging-Modulation Markers.
Spermidine and spermine delay brain aging by inducing autophagy in SAMP8 mice.
Microglia senescence occurs in both substantia nigra and ventral tegmental area.
Towards an understanding of the physical activity-BDNF-cognition triumvirate: A review of associations and dosage.
Impact of BDNF and sex on maintaining intact memory function in early midlife.
MeSH Terms
- Brain
- Brain-Derived Neurotrophic Factor
- Cognition
- Female
- Humans
- Magnetic Resonance Imaging
- Male
- Memory
- Memory, Short-Term
- Menopause
- Middle Aged
- Neuroprotective Agents
- Neuropsychological Tests
- Reproduction
- Sex Characteristics
Keywords
- Aging
- BDNF
- Hormones
- Memory
- Menopause
- Sex differences
Testosterone replacement causes dose-dependent improvements in spatial memory among aged male rats.
The effects of aerobic exercise intensity on memory in older adults.
Protective effects of vitamin D on neurophysiologic alterations in brain aging: role of brain-derived neurotrophic factor (BDNF).
Differential Effects of Physical Exercise, Cognitive Training, and Mindfulness Practice on Serum BDNF Levels in Healthy Older Adults: A Randomized Controlled Intervention Study.
MeSH Terms
- Aged
- Brain-Derived Neurotrophic Factor
- Cognition
- Correlation of Data
- Exercise
- Female
- Healthy Aging
- Healthy Lifestyle
- Humans
- Learning
- Male
- Mindfulness
- Neuropsychological Tests
- Outcome Assessment, Health Care
Keywords
- Aging
- brain-derived neurotrophic factor
- cognitive training
- mindfulness
- physical exercise
Dietary Supplementation with Fish Oil or Conjugated Linoleic Acid Relieves Depression Markers in Mice by Modulation of the Nrf2 Pathway.
MeSH Terms
- Aging
- Animals
- Antidepressive Agents
- Autoimmunity
- Biomarkers
- Brain
- Brain-Derived Neurotrophic Factor
- Depression
- Dietary Supplements
- Docosahexaenoic Acids
- Fatty Acid Elongases
- Fatty Acids
- Fish Oils
- Inflammation
- Linoleic Acids, Conjugated
- Liver
- Male
- Mice, Inbred MRL lpr
- NF-E2-Related Factor 2
- Oxidative Stress
- Stearoyl-CoA Desaturase
- Tumor Necrosis Factor-alpha
Keywords
- brain derived neurotrophic factor
- brain fatty acid profile
- conjugated linoleic acid
- depression
- fish oil
- nuclear erythroid related factor-2
BGN
Alterations of local functional connectivity in lifespan: A resting-state fMRI study.
BHLHE40
Thyroid hormone induces cellular senescence in prostate cancer cells through induction of DEC1.
MeSH Terms
- Basic Helix-Loop-Helix Transcription Factors
- Cell Line, Tumor
- Cell Proliferation
- Cellular Senescence
- Cyclin-Dependent Kinase Inhibitor p15
- Homeodomain Proteins
- Humans
- Male
- Prostatic Neoplasms
- Thyroid Hormones
Keywords
- BHLHE40
- Cellular senescence
- DEC1
- Prostate cancer
- Thyroid hormone
BLM
[Olmesartan inhibits age-associated migration and invasion of human aortic vascular smooth muscle cells by upregulating miR-3133 axis].
BMI1
Senescence Induced by BMI1 Inhibition Is a Therapeutic Vulnerability in H3K27M-Mutant DIPG.
BMP2
Interleukin-1β-Induced Senescence Promotes Osteoblastic Transition of Vascular Smooth Muscle Cells.
BMP4
Direct reprogramming of human smooth muscle and vascular endothelial cells reveals defects associated with aging and Hutchinson-Gilford progeria syndrome.
BMP7
Downregulation of miR-542-3p promotes osteogenic transition of vascular smooth muscle cells in the aging rat by targeting BMP7.
BOC
Protein Requirements of Elderly Chinese Adults Are Higher than Current Recommendations.
MeSH Terms
- Aged
- Aging
- Amino Acids
- Body Weight
- China
- Dietary Proteins
- Energy Intake
- Energy Metabolism
- Female
- Humans
- Male
- Nutritional Requirements
- Oxidation-Reduction
- Phenylalanine
- Recommended Dietary Allowances
- Tyrosine
Keywords
- indicator amino acid oxidation
- older adults
- phenylalanine oxidation
- protein requirement
- stable isotope
BPI
High TARC plasma levels confer protection to long living individuals by inducing M2 profile.
Circulating BPIFB4 Levels Associate With and Influence the Abundance of Reparative Monocytes and Macrophages in Long Living Individuals.
BPIFB4
New Insights for BPIFB4 in Cardiovascular Therapy.
LAV-BPIFB4 associates with reduced frailty in humans and its transfer prevents frailty progression in old mice.
BRAF
Conditional reprograming culture conditions facilitate growth of lower grade glioma models.
Active notch protects MAPK activated melanoma cell lines from MEK inhibitor cobimetinib.
Mitochondrial metabolic reprograming via BRAF inhibition ameliorates senescence.
BRD2
Brd2 haploinsufficiency extends lifespan and healthspan in C57B6/J mice.
BRD4
Inhibition of BRD4 triggers cellular senescence through suppressing aurora kinases in oesophageal cancer cells.
BRD4 contributes to LPS-induced macrophage senescence and promotes progression of atherosclerosis-associated lipid uptake.
BET Proteins Are Required for Transcriptional Activation of the Senescent Islet Cell Secretome in Type 1 Diabetes.
MeSH Terms
- Animals
- Cell Cycle Proteins
- Cellular Senescence
- Diabetes Mellitus, Type 1
- Female
- Humans
- Insulin-Secreting Cells
- Islets of Langerhans
- Mice
- Mice, Inbred NOD
- Paracrine Communication
- Protein Binding
- Transcription Factors
- Transcriptional Activation
Keywords
- BET proteins
- beta cells
- senescence and SASP
- type 1 diabetes
BTK
Amelioration of age-related brain function decline by Bruton's tyrosine kinase inhibition.
C2
[Effects of resistance training on mitochondrial function in skeletal muscle of aging rats].
Structural and functional characterization of Solanum lycopersicum phosphatidylinositol 3-kinase C2 domain.
C3
Inverse association between periumbilical fat and longevity mediated by complement C3 and cardiac structure.
Complement C3 deficiency ameliorates aging related changes in the kidney.
Reduced sialylation triggers homeostatic synapse and neuronal loss in middle-aged mice.
[Comparative analysis of experimental data about the effects of various polyphenols on lifespan and aging.]
MeSH Terms
- Animals
- Antioxidants
- Female
- Longevity
- Male
- Mice
- Mice, Inbred BALB C
- Polyphenols
- Survival Analysis
Keywords
- BP-C3
- Gompertz model
- SkQ1
- aging
- herbal extracts
- lifespan
- metformin
- polyphenols
- resveratrol
- tocopherol
C5
The C5-75 Program: Meeting the Need for Efficient, Pragmatic Frailty Screening and Management in Primary Care.
Can a relatively large spinal cord for the dural sac influence severity of paralysis in elderly patients with cervical spinal cord injury caused by minor trauma?
C6
Evolution of the Aroma of Treixadura Wines during Bottle Aging.
D-galactose induces senescence of glioblastoma cells through YAP-CDK6 pathway.
C7
The Vertebral Artery Convergence to the Cervical Spine in Elders.
C9
C9orf72 in myeloid cells suppresses STING-induced inflammation.
Glycine-alanine dipeptide repeats spread rapidly in a repeat length- and age-dependent manner in the fly brain.
Human iPSC-derived astrocytes from ALS patients with mutated C9ORF72 show increased oxidative stress and neurotoxicity.
MeSH Terms
- Amyotrophic Lateral Sclerosis
- Animals
- Astrocytes
- Biomarkers
- C9orf72 Protein
- Cells, Cultured
- Cellular Reprogramming
- Cellular Senescence
- Cerebral Cortex
- Disease Models, Animal
- Gene Expression Profiling
- Glutamic Acid
- Humans
- Induced Pluripotent Stem Cells
- Mice
- Motor Neurons
- Mutation
- Oxidative Stress
- Proteomics
- Reactive Oxygen Species
Keywords
- Amyotrophic lateral sclerosis
- Astrocytes
- Neurotoxicity
- Oxidative stress
- Senescence
- iPSC
C9orf72
Carriership of two copies of C9orf72 hexanucleotide repeat intermediate-length alleles is a risk factor for ALS in the Finnish population.
CA1
The relation between tau pathology and granulovacuolar degeneration of neurons.
Memory and dendritic spines loss, and dynamic dendritic spines changes are age-dependent in the rat.
Deregulated expression of a longevity gene, Klotho, in the C9orf72 deletion mice with impaired synaptic plasticity and adult hippocampal neurogenesis.
COX5A Plays a Vital Role in Memory Impairment Associated With Brain Aging [i]via[/i] the BDNF/ERK1/2 Signaling Pathway.
Changes of fat-mass and obesity-associated protein expression in the hippocampus in animal models of high-fat diet-induced obesity and D-galactose-induced aging.
Phenylbutyrate ameliorates prefrontal cortex, hippocampus, and nucleus accumbens neural atrophy as well as synaptophysin and GFAP stress in aging mice.
Heterogeneity in brain distribution of activated microglia and astrocytes in a rat ischemic model of Alzheimer's disease after 2 years of survival.
Hippocampal Subregion Transcriptomic Profiles Reflect Strategy Selection during Cognitive Aging.
Associations between pattern separation and hippocampal subfield structure and function vary along the lifespan: A 7 T imaging study.
Laminarin Pretreatment Provides Neuroprotection against Forebrain Ischemia/Reperfusion Injury by Reducing Oxidative Stress and Neuroinflammation in Aged Gerbils.
Age-dependent Alteration in Mitochondrial Dynamics and Autophagy in Hippocampal Neuron of Cannabinoid CB1 Receptor-deficient Mice.
Functional Connectivity of Hippocampal CA3 Predicts Neurocognitive Aging via CA1-Frontal Circuit.
Integration of qRT-PCR and Immunohistochemical Techniques for mRNA Expression and Localization of m1AChR in the Brain of Aging Rat.
Role of Eclipta prostrata extract in improving spatial learning and memory deficits in D-galactose-induced aging in rats.
MeSH Terms
- Aging
- Animals
- Behavior, Animal
- CA1 Region, Hippocampal
- Catalase
- Dopamine
- Eclipta
- Galactose
- Gene Expression Regulation, Enzymologic
- Glutathione Peroxidase
- Glutathione Reductase
- Male
- Memory Disorders
- Nitric Oxide
- Nitric Oxide Synthase Type II
- Norepinephrine
- Plant Extracts
- RNA, Messenger
- Rats
- Rats, Sprague-Dawley
- Serotonin
- Spatial Learning
- Superoxide Dismutase
Keywords
- Antioxidants
- Eclipta
- Galactose
- Memory disorders
- Spatial learning
Differential annualized rates of hippocampal subfields atrophy in aging and future Alzheimer's clinical syndrome.
Rectification of radiotherapy-induced cognitive impairments in aged mice by reconstituted Sca-1 stem cells from young donors.
MeSH Terms
- Animals
- Behavior, Animal
- Cognitive Dysfunction
- Dendritic Spines
- Hematopoietic Stem Cell Transplantation
- Hippocampus
- Humans
- Long-Term Potentiation
- Maze Learning
- Memory
- Mice
- Neurons
- Radiotherapy
- Recovery of Function
- Spinocerebellar Ataxias
- Treatment Outcome
Keywords
- Aging
- Bone marrow stem cells
- Learning and memory
- Microglia
- Radiotherapy
Increasing neurogenesis refines hippocampal activity rejuvenating navigational learning strategies and contextual memory throughout life.
Memory Performance Correlates of Hippocampal Subfield Volume in Mild Cognitive Impairment Subtype.
Spermidine protects from age-related synaptic alterations at hippocampal mossy fiber-CA3 synapses.
Methylene blue inhibits Caspase-6 activity, and reverses Caspase-6-induced cognitive impairment and neuroinflammation in aged mice.
MeSH Terms
- Aging
- Animals
- Caspase 6
- Caspase Inhibitors
- Cognitive Dysfunction
- Female
- Humans
- Inflammation
- Male
- Methylene Blue
- Mice
- Mice, Inbred C57BL
- Mice, Knockout
- Mice, Transgenic
Keywords
- Alzheimer disease
- Axonal degeneration
- Caspase-6
- Caspase-6 inhibitor
- Hippocampal CA1
- Hippocampal fibres
- Methylene blue
- Synaptic plasticity
- White matter
Long-term Memory Upscales Volume of Postsynaptic Densities in the Process that Requires Autophosphorylation of αCaMKII.
PACAP27 mitigates an age-dependent hippocampal vulnerability to PGJ2-induced spatial learning deficits and neuroinflammation in mice.
Inhibition of oxidative stress by testosterone improves synaptic plasticity in senescence accelerated mice.
Restored presynaptic synaptophysin and cholinergic inputs contribute to the protective effects of physical running on spatial memory in aged mice.
Senescent neurophysiology: Ca signaling from the membrane to the nucleus.
MeSH Terms
- Aging
- Animals
- CA1 Region, Hippocampal
- Calcium Signaling
- Cell Nucleus
- Epigenesis, Genetic
- Excitatory Postsynaptic Potentials
- Humans
- Membrane Potentials
- Neuronal Plasticity
- Pyramidal Cells
- Receptors, N-Methyl-D-Aspartate
Keywords
- Afterhyperpolarization
- Aging
- Epigenetics
- Hippocampus
- N-methyl-D-aspartate receptor
- Synaptic plasticity
- Transcription
CA2
Maintaining Aging Hippocampal Function with Safe and Feasible Shaking Exercise in SAMP10 Mice.
One-year Follow-up Study of Hippocampal Subfield Atrophy in Alzheimer's Disease and Normal Aging.
MeSH Terms
- Aged
- Aged, 80 and over
- Aging
- Alzheimer Disease
- Atrophy
- Case-Control Studies
- Cognitive Dysfunction
- Disease Progression
- Female
- Follow-Up Studies
- Hippocampus
- Humans
- Magnetic Resonance Imaging
- Male
- Neuroimaging
Keywords
- Alzheimer's disease
- biomarker
- hippocampal
- mild cognitive impairment
- neurodegenerative diseases
- normal aging
- radial distance
- subfield atrophy
Maturation of PNN and ErbB4 Signaling in Area CA2 during Adolescence Underlies the Emergence of PV Interneuron Plasticity and Social Memory.
MeSH Terms
- Aging
- Animals
- Animals, Newborn
- CA2 Region, Hippocampal
- Interneurons
- Long-Term Synaptic Depression
- Male
- Memory
- Mice
- Mice, Inbred C57BL
- Neural Inhibition
- Neuregulin-1
- Neuronal Plasticity
- Parvalbumins
- Receptor, ErbB-4
- Receptors, Opioid, delta
- Signal Transduction
- Social Behavior
- Synapses
- gamma-Aminobutyric Acid
Keywords
- ErbB4
- adolescence
- area CA2
- delta opioid receptors
- hippocampus
- long-term depression
- neuregulin 1
- parvalbumin interneuron
- perineuronal net
- social memory
CA3
Features of Postnatal Hippocampal Development in a Rat Model of Sporadic Alzheimer's Disease.
Age-Related Changes in Synaptic Plasticity Associated with Mossy Fiber Terminal Integration during Adult Neurogenesis.
Metabotropic Glutamate Receptors at the Aged Mossy Fiber - CA3 Synapse of the Hippocampus.
CACNA1S
Increased calcium channel in the lamina propria of aging rat.
CAD
Serum soluble Klotho is inversely related to coronary artery calcification assessed by intravascular ultrasound in patients with stable coronary artery disease.
Shear bond strengths of aged and non-aged CAD/CAM materials after different surface treatments.
Prediction of Early Postoperative Major Cardiac Events and In-Hospital Mortality in Elderly Hip Fracture Patients: The Role of Different Types of Preoperative Cardiac Abnormalities on Echocardiography Report.
MeSH Terms
- Aged
- Aortic Valve Stenosis
- Cardiovascular Diseases
- Comorbidity
- Echocardiography
- Female
- Fracture Fixation
- Hip Fractures
- Hospital Mortality
- Humans
- Male
- Postoperative Complications
- Prognosis
- Risk Factors
Keywords
- aging
- echocardiographic abnormality
- hip fracture surgery
- mortality
- postoperative cardiac complications
[Polymorbidity in elderly patients needing myocardial revascularization (a review article).]
MeSH Terms
- Aged
- Cognitive Dysfunction
- Coronary Artery Disease
- Humans
- Myocardial Revascularization
- Quality of Life
- Risk
Keywords
- aging
- elderly
- ischemic heart disease
- myocardial revascularization
- polymorbidity
Fracture force of CAD/CAM resin composite crowns after in vitro aging.
Clinical performance of chairside monolithic lithium disilicate glass-ceramic CAD-CAM crowns.
Acute resveratrol supplementation in coronary artery disease: towards patient stratification.
MeSH Terms
- Aged
- Biomarkers
- Brachial Artery
- Cardiac Rehabilitation
- Coronary Artery Bypass
- Coronary Artery Disease
- Cross-Over Studies
- Exercise Therapy
- Female
- Humans
- Kinetics
- Male
- Middle Aged
- Oxygen
- Oxygen Consumption
- Percutaneous Coronary Intervention
- Resveratrol
- Single-Blind Method
- Treatment Outcome
- Vasodilation
Keywords
- Antioxidant
- aging
- endothelial dysfunction
- oxygen uptake
CARM1
CARM1 regulates senescence during airway epithelial cell injury in COPD pathogenesis.
MeSH Terms
- Aged
- Animals
- Apoptosis
- Cell Differentiation
- Cell Proliferation
- Cellular Senescence
- Epithelial Cells
- Female
- Humans
- Male
- Mice, Inbred C57BL
- Mice, Knockout
- Middle Aged
- Naphthalenes
- Protein-Arginine N-Methyltransferases
- Pulmonary Disease, Chronic Obstructive
- Respiratory Mucosa
- Wound Healing
Keywords
- CARM1
- COPD
- airway epithelium
- senescence
CASP3
Does cartilage ERα overexpression correlate with osteoarthritic chondrosenescence? Indications from [i]Labisia pumila[/i] OA mitigation.
MeSH Terms
- Aging
- Animals
- Bone Development
- Cartilage
- Chondrocytes
- Diclofenac
- Disease Models, Animal
- Estrogen Receptor alpha
- Flavonoids
- Gallic Acid
- Gene Expression Regulation
- Humans
- Iodoacetates
- Matrix Metalloproteinase 13
- Metabolism
- Osteoarthritis
- Ovariectomy
- Plant Extracts
- Primulaceae
- Rats
CAT
Training improves the handling of inhaler devices and reduces the severity of symptoms in geriatric patients suffering from chronic-obstructive pulmonary disease.
7-chloro-4-(phenylselanyl) quinoline co-treatment prevent oxidative stress in diabetic-like phenotype induced by hyperglycidic diet in Drosophila melanogaster.
Aging influences in the blood-brain barrier permeability and cerebral oxidative stress in sepsis.
2 -Deoxy - d-glucose at chronic low dose acts as a caloric restriction mimetic through a mitohormetic induction of ROS in the brain of accelerated senescence model of rat.
Ceftriaxone improves senile neurocognition damages induced by D-galactose in mice.
Ginsenoside Rg1 protects against d-galactose induced fatty liver disease in a mouse model via FOXO1 transcriptional factor.
MeSH Terms
- Animals
- Antioxidants
- Cellular Senescence
- Disease Models, Animal
- Fatty Liver
- Forkhead Box Protein O1
- Galactose
- Ginsenosides
- Lipid Peroxidation
- Male
- Medicine, Chinese Traditional
- Mice
- Mice, Inbred C57BL
- Oxidative Stress
- Protective Agents
- Transcription Factors
Keywords
- D-galactose
- FOXO1
- Non-alcoholic fatty liver disease
- Rg1
- Senescence
Effects of long-term intermittent versus chronic calorie restriction on oxidative stress in a mouse cancer model.
MeSH Terms
- Aging
- Animals
- Antioxidants
- Caloric Restriction
- Catalase
- Erythrocytes
- Female
- Glutathione
- Lipid Peroxidation
- Malondialdehyde
- Mammary Neoplasms, Experimental
- Mice, Inbred C57BL
- Oxidative Stress
- Superoxide Dismutase
Keywords
- MMTV-TGF-α mice
- breast cancer
- energy restriction
- intermittent calorie restriction
- mammary tumor
- oxidative stress
The Toxicity of Nonaged and Aged Coated Silver Nanoparticles to Freshwater Alga Raphidocelis subcapitata.
MeSH Terms
- Aquatic Organisms
- Chlorophyta
- Fresh Water
- Hydrodynamics
- Lipid Peroxidation
- Metal Nanoparticles
- Particle Size
- Reactive Oxygen Species
- Silver
- Static Electricity
- Toxicity Tests
Keywords
- Aquatic toxicology
- Ecotoxicology
- Environmental fate
- Heavy metals
- Nanoparticle aging
- Nanotoxicology
CBS
Permanent cystathionine-β-Synthase gene knockdown promotes inflammation and oxidative stress in immortalized human adipose-derived mesenchymal stem cells, enhancing their adipogenic capacity.
Cardiovascular phenotype of mice lacking 3-mercaptopyruvate sulfurtransferase.
MeSH Terms
- Animals
- Antioxidants
- Cardiovascular System
- Cystathionine beta-Synthase
- Cystathionine gamma-Lyase
- Gene Expression Regulation, Enzymologic
- Hydrogen Sulfide
- Male
- Mice, Inbred C57BL
- Mice, Knockout
- Myocardial Reperfusion Injury
- Myocytes, Cardiac
- Nitric Oxide
- Phenotype
- Reactive Oxygen Species
- Sulfurtransferases
- Vasodilation
Keywords
- 3-mercaptopyruvate transferase (3-MST)
- Aging
- Blood pressure
- Myocardial infarction
- Nitric Oxide (NO)
- Reactive Oxygen Species (ROS)
CBX3
Biological functions of chromobox (CBX) proteins in stem cell self-renewal, lineage-commitment, cancer and development.
CCK
Senolytic agent Quercetin ameliorates intervertebral disc degeneration via the Nrf2/NF-κB axis.
Astragalus improve aging bone marrow mesenchymal stem cells (BMSCs) vitality and osteogenesis through VD-FGF23-Klotho axis.
Effects of Age on Acute Appetite-Related Responses to Whey-Protein Drinks, Including Energy Intake, Gastric Emptying, Blood Glucose, and Plasma Gut Hormone Concentrations-A Randomized Controlled Trial.
Lactose induced redox-dependent senescence and activated Nrf2 pathway.
Quercetin Suppresses the Progression of Atherosclerosis by Regulating MST1-Mediated Autophagy in ox-LDL-Induced RAW264.7 Macrophage Foam Cells.
MeSH Terms
- Adenine
- Animals
- Atherosclerosis
- Autophagy
- Cell Survival
- Cellular Senescence
- Cyclin-Dependent Kinase Inhibitor p16
- Cyclin-Dependent Kinase Inhibitor p21
- Disease Progression
- Foam Cells
- Hepatocyte Growth Factor
- Lipid Metabolism
- Lipoproteins, LDL
- Mice
- Proto-Oncogene Proteins
- Quercetin
- RAW 264.7 Cells
- Sirolimus
- Up-Regulation
Keywords
- RAW264.7
- atherosclerosis
- autophagy
- quercetin
- senescence
LncRNA AW112010 Promotes Mitochondrial Biogenesis and Hair Cell Survival: Implications for Age-Related Hearing Loss.
Effects of age on feeding response: Focus on the rostral C1 neuron and its glucoregulatory proteins.
Ser-Tyr and Asn-Ala, vasorelaxing dipeptides found by comprehensive screening, reduce blood pressure via different age-dependent mechanisms.
MeSH Terms
- Aging
- Amino Acid Sequence
- Animals
- Antihypertensive Agents
- Blood Pressure
- Cholecystokinin
- Dipeptides
- Drug Evaluation, Preclinical
- Hypertension
- Male
- Mesenteric Arteries
- Nitric Oxide
- Peptide Library
- Proglumide
- Rats
- Rats, Inbred SHR
- Receptors, Cholecystokinin
- Vasodilation
- Vasodilator Agents
Keywords
- aging
- dipeptide library
- nitric oxide
- structure-activity relationship
- vasorelaxation
Fisetin, via CKIP-1/REGγ, limits oxidized LDL-induced lipid accumulation and senescence in RAW264.7 macrophage-derived foam cells.
CCL11
CCL-11 or Eotaxin-1: An Immune Marker for Ageing and Accelerated Ageing in Neuro-Psychiatric Disorders.
CCL17
Aging and chronic high-fat feeding negatively affects kidney size, function, and gene expression in CTRP1-deficient mice.
CCL19
Age-Related Gliosis Promotes Central Nervous System Lymphoma through CCL19-Mediated Tumor Cell Retention.
MeSH Terms
- Adolescent
- Adult
- Aged
- Aging
- Animals
- Astrocytes
- Blood-Brain Barrier
- Cell Line, Tumor
- Central Nervous System Neoplasms
- Chemokine CCL19
- Chemokine CXCL12
- Disease Models, Animal
- Female
- Gliosis
- Humans
- Intravital Microscopy
- Lymphoma
- Male
- Mice
- Mice, Transgenic
- Microscopy, Fluorescence, Multiphoton
- Middle Aged
- NF-kappa B
- Receptors, CCR7
- Time-Lapse Imaging
- Young Adult
Keywords
- CCL19
- CNSL
- CXCL12
- DLBCL
- PCNSL
- SCNSL
- gliosis
- lymphoma
- metastasis
- neuroinflammation
CCL2
β1 Integrin regulates adult lung alveolar epithelial cell inflammation.
MeSH Terms
- Aging
- Alveolar Epithelial Cells
- Animals
- Cell Adhesion
- Chemokine CCL2
- Chemokines
- Disease Models, Animal
- Epithelium
- Integrin beta1
- Lung
- Macrophages
- Mice
- Mice, Inbred C57BL
- Mice, Knockout
- Pneumonia
- Pulmonary Disease, Chronic Obstructive
- Receptors, CCR2
Keywords
- COPD
- Inflammation
- Integrins
- Macrophages
- Pulmonology
CCL20
p53 and p53-related mediators PAI-1 and IGFBP-3 are downregulated in peripheral blood mononuclear cells of HIV-patients exposed to non-nucleoside reverse transcriptase inhibitors.
CCL28
Age-related chemokine alterations affect IgA secretion and gut immunity in female mice.
CCN1
Sodium tanshinone IIA sulfonate restrains fibrogenesis through induction of senescence in mice with induced deep endometriosis.
Inhibition of cellular communication network factor 1 (CCN1)-driven senescence slows down cartilage inflammaging and osteoarthritis.
The senescence-associated matricellular protein CCN1 in plasma of human subjects with idiopathic pulmonary fibrosis.
MeSH Terms
- Aged
- Cellular Senescence
- Cysteine-Rich Protein 61
- Disease Progression
- Enzyme-Linked Immunosorbent Assay
- Female
- Humans
- Idiopathic Pulmonary Fibrosis
- Male
- Middle Aged
- Outcome Assessment, Health Care
- Predictive Value of Tests
- Survival Rate
Keywords
- CCN1
- Cellular senescence
- Idiopathic pulmonary fibrosis
- Transplant-free survival
CCN3
CCN3 Signaling Is Differently Regulated in Placental Diseases Preeclampsia and Abnormally Invasive Placenta.
CCN3 (NOV) Drives Degradative Changes in Aging Articular Cartilage.
CCND1
Effects of hydrogen peroxide, doxorubicin and ultraviolet irradiation on senescence of human dental pulp stem cells.
CCND3
The effect of aging on the biological and immunological characteristics of periodontal ligament stem cells.
CCR2
Hip Fracture Leads to Transitory Immune Imprint in Older Patients.
The CC-chemokine receptor 2 is involved in the control of ovarian folliculogenesis and fertility lifespan in mice.
Deficit of resolution receptor magnifies inflammatory leukocyte directed cardiorenal and endothelial dysfunction with signs of cardiomyopathy of obesity.
Tet2-mediated clonal hematopoiesis in nonconditioned mice accelerates age-associated cardiac dysfunction.
Inflammation and Ectopic Fat Deposition in the Aging Murine Liver Is Influenced by CCR2.
Klotho-mediated targeting of CCL2 suppresses the induction of colorectal cancer progression by stromal cell senescent microenvironments.
MeSH Terms
- Aged
- Cell Line, Tumor
- Cell Movement
- Cell Proliferation
- Cellular Microenvironment
- Cellular Senescence
- Chemokine CCL2
- Colorectal Neoplasms
- Disease Progression
- Down-Regulation
- Doxorubicin
- Female
- Glucuronidase
- Human Umbilical Vein Endothelial Cells
- Humans
- Male
- Middle Aged
- NF-kappa B
- Neoplasm Invasiveness
- Proportional Hazards Models
- Signal Transduction
- Stromal Cells
Keywords
- CCL2
- Klotho
- colorectal cancer
- senescence
CCR3
Low Molecular Weight Hyaluronan Induces an Inflammatory Response in Ovarian Stromal Cells and Impairs Gamete Development In Vitro.
MeSH Terms
- Aging
- Animals
- Extracellular Matrix
- Female
- Germ Cells
- Granulosa Cells
- Hyaluronan Receptors
- Hyaluronic Acid
- Inflammation
- Mice
- Mice, Inbred BALB C
- Mice, Inbred C57BL
- Molecular Weight
- Ovary
- Stromal Cells
Keywords
- hyaluronan fragments
- inflammation
- ovarian biology
- reproductive aging
- stroma
CCR5
[Enhancement can do harm].
CCS
Frailty Significantly Associated with a Risk for Mid-term Outcomes in Elderly Chronic Coronary Syndrome Patients: a Prospective Study.
Microbleeds and Medial Temporal Atrophy Determine Cognitive Trajectories in Normal Aging: A Longitudinal PET-MRI Study.
Hippocampal Volume Loss, Brain Amyloid Accumulation, and APOE Status in Cognitively Intact Elderly Subjects.
Amyloid Load, Hippocampal Volume Loss, and Diffusion Tensor Imaging Changes in Early Phases of Brain Aging.
Lower bone mass is associated with subclinical atherosclerosis, endothelial dysfunction and carotid thickness in the very elderly.
CD14
Human innate immune cell crosstalk induces melanoma cell senescence.
Fusion Potential of Human Osteoclasts In Vitro Reflects Age, Menopause, and In Vivo Bone Resorption Levels of Their Donors-A Possible Involvement of DC-STAMP.
Association of CD14 with incident dementia and markers of brain aging and injury.
Compromised Bone Healing in Aged Rats Is Associated With Impaired M2 Macrophage Function.
MeSH Terms
- Age Factors
- Aging
- Animals
- Antigens, CD
- Antigens, Differentiation, Myelomonocytic
- Biomarkers
- Bone Regeneration
- Bone and Bones
- Female
- Fractures, Bone
- Gene Expression
- Lipopolysaccharide Receptors
- Macrophages
- Osteotomy
- Rats, Sprague-Dawley
- Wound Healing
Keywords
- CD14+ cells
- aging
- angiogenesis
- bone regeneration
- compromised healing
- macrophage
- monocyte
CD19
Sequential treatment with aT19 cells generates memory CAR-T cells and prolongs the lifespan of Raji-B-NDG mice.
MeSH Terms
- Animals
- Antigens, CD19
- Cell Line, Tumor
- Combined Modality Therapy
- Disease-Free Survival
- HEK293 Cells
- Healthy Volunteers
- Humans
- Immunologic Memory
- Immunotherapy, Adoptive
- Longevity
- Lymphoma, B-Cell
- Mice
- Neoplasm Recurrence, Local
- Receptors, Chimeric Antigen
- Recombinant Proteins
- Remission Induction
- T-Lymphocytes
- Time Factors
- Transduction, Genetic
- Transplantation, Autologous
- Xenograft Model Antitumor Assays
Keywords
- Autologous CD19 T cells
- Chimeric antigen receptor
- Memory T cells
- Sequential therapy
CD27
CMV-independent increase in CD27-CD28+ CD8+ EMRA T cells is inversely related to mortality in octogenarians.
Compartmentalized cytotoxic immune response leads to distinct pathogenic roles of natural killer and senescent CD8 T cells in human cutaneous leishmaniasis.
MeSH Terms
- CD56 Antigen
- CD57 Antigens
- Case-Control Studies
- Cellular Senescence
- Cytotoxicity, Immunologic
- Female
- Gene Expression Regulation
- Host-Parasite Interactions
- Humans
- Interferon-gamma
- Killer Cells, Natural
- Lectins, C-Type
- Leishmania braziliensis
- Leishmaniasis, Cutaneous
- Male
- Oligosaccharides
- Receptors, Immunologic
- Severity of Illness Index
- Sialyl Lewis X Antigen
- Signal Transduction
- Skin
- T-Lymphocytes, Cytotoxic
Keywords
Leishmania braziliensis
- CD8+ T cells
- cellular senescence
- cutaneous leishmaniasis
- immunopathology
- natural killer cells
CD27- IgD- B cell memory subset associates with inflammation and frailty in elderly individuals but only in males.
CD28
Premature CD4 T Cells Senescence Induced by Chronic Infection in Patients with Acute Coronary Syndrome.
The IMMENSE Study: The Interplay Between iMMune and ENdothelial Cells in Mediating Cardiovascular Risk in Systemic Lupus Erythematosus.
Emergence of T cell immunosenescence in diabetic chronic kidney disease.
The relationship between Chlamydia pneumoniae infection and CD4/CD8 ratio, lymphocyte subsets in middle-aged and elderly individuals.
Next steps in mechanisms of inflammaging.
A randomized pilot trial to evaluate the benefit of the concomitant use of atorvastatin and Raltegravir on immunological markers in protease-inhibitor-treated subjects living with HIV.
MeSH Terms
- Adult
- Anti-HIV Agents
- Anticholesteremic Agents
- Atorvastatin
- CD4-Positive T-Lymphocytes
- CD8-Positive T-Lymphocytes
- Female
- HIV Infections
- HIV Protease Inhibitors
- Humans
- Immunosenescence
- Inflammation
- Lymphocyte Activation
- Male
- Middle Aged
- Pilot Projects
- Raltegravir Potassium
Aging affects responsiveness of peripheral blood mononuclear cells to immunosuppression of periodontal ligament stem cells.
Comparison of Donepezil, Memantine, Melatonin, and Liuwei Dihuang Decoction on Behavioral and Immune Endocrine Responses of Aged Senescence-Accelerated Mouse Resistant 1 Mice.
Immunosenescent characteristics of T cells in young patients following haploidentical haematopoietic stem cell transplantation from parental donors.
Diagnosis-independent loss of T-cell costimulatory molecules in individuals with cytomegalovirus infection.
Accelerated immunosenescence in rheumatoid arthritis: impact on clinical progression.
Accelerated immune aging was correlated with lupus-associated brain fog in reproductive-age systemic lupus erythematosus patients.
Liver fibrosis and accelerated immune dysfunction (immunosenescence) among HIV-infected Russians with heavy alcohol consumption - an observational cross-sectional study.
MeSH Terms
- Adult
- Alcoholism
- CD28 Antigens
- CD4-Positive T-Lymphocytes
- CD57 Antigens
- CD8-Positive T-Lymphocytes
- Cross-Sectional Studies
- Female
- HIV Infections
- Hepatitis C
- Humans
- Immunologic Memory
- Immunosenescence
- Leukocyte Common Antigens
- Linear Models
- Liver Cirrhosis, Alcoholic
- Male
- Phenotype
- Randomized Controlled Trials as Topic
- Russia
- Zinc
Keywords
- Alcohol
- HIV
- Immune senescence
- Liver fibrosis
- Russia
Effect of Allogenic Bone Marrow Mesenchymal Stem Cell Transplantation on T Cells of Old Mice.
Peripheral antibody concentrations are associated with highly differentiated T cells and inflammatory processes in the human bone marrow.
CD33
Maximum reproductive lifespan correlates with CD33rSIGLEC gene number: Implications for NADPH oxidase-derived reactive oxygen species in aging.
CD34
Comparing the Effect of TGF-β Receptor Inhibition on Human Perivascular Mesenchymal Stromal Cells Derived from Endometrium, Bone Marrow and Adipose Tissues.
ACE2/ACE imbalance and impaired vasoreparative functions of stem/progenitor cells in aging.
Innovative Mind-Body Intervention Day Easy Exercise Increases Peripheral Blood CD34 Cells in Adults.
Human Thymic Involution and Aging in Humanized Mice.
Coinhibition of activated p38 MAPKα and mTORC1 potentiates stemness maintenance of HSCs from SR1-expanded human cord blood CD34 cells via inhibition of senescence.
Bulk and single-cell gene expression analyses reveal aging human choriocapillaris has pro-inflammatory phenotype.
MeSH Terms
- Age Factors
- Aged
- Aged, 80 and over
- Aging
- Choroid
- Endothelial Cells
- Female
- Gene Expression Regulation
- Humans
- Infant
- Infant, Newborn
- Inflammation
- Inflammation Mediators
- Macular Degeneration
- Male
- Middle Aged
- Phenotype
- Sequence Analysis, RNA
- Single-Cell Analysis
Keywords
- Age-related macular degeneration
- Choriocapillaris
- Choroid
- Infant
- Pericytes
- Single-cell
Mesenchymal stem cells repair bone marrow damage of aging rats and regulate autophagy and aging genes.
Immune cell extracellular vesicles and their mitochondrial content decline with ageing.
Young and elderly oral squamous cell carcinoma patients present similar angiogenic profile and predominance of M2 macrophages: Comparative immunohistochemical study.
MeSH Terms
- Adult
- Aged
- Aged, 80 and over
- Antigens, CD
- Antigens, Differentiation, Myelomonocytic
- Carcinoma, Squamous Cell
- Female
- Humans
- Immunohistochemistry
- Immunosenescence
- Macrophages
- Male
- Middle Aged
- Mouth Neoplasms
- Neovascularization, Pathologic
- Receptors, Cell Surface
- Tumor Microenvironment
Keywords
- M1 and M2 macrophages
- angiogenesis
- immunohistochemistry
- immunosenescence
- oral squamous cell carcinoma
CD36
Liver osteopontin is required to prevent the progression of age-related nonalcoholic fatty liver disease.
Reduction of senescence-associated beta-galactosidase activity by vitamin E in human fibroblasts depends on subjects' age and cell passage number.
Niacin-mediated rejuvenation of macrophage/microglia enhances remyelination of the aging central nervous system.
CD38
Re-equilibration of imbalanced NAD metabolism ameliorates the impact of telomere dysfunction.
TNFRSF12A and CD38 Contribute to a Vicious Circle for Chronic Obstructive Pulmonary Disease by Engaging Senescence Pathways.
Aging alters acetylation status in skeletal and cardiac muscles.
CD38 in Neurodegeneration and Neuroinflammation.
CD38, a Receptor with Multifunctional Activities: From Modulatory Functions on Regulatory Cell Subsets and Extracellular Vesicles, to a Target for Therapeutic Strategies.
CD38 Deficiency Alleviates D-Galactose-Induced Myocardial Cell Senescence Through NAD /Sirt1 Signaling Pathway.
CD4
Identification of Key Genes and Potential New Biomarkers for Ovarian Aging: A Study Based on RNA-Sequencing Data.
Distinct Age-Related Epigenetic Signatures in CD4 and CD8 T Cells.
IL-1β-MyD88-mTOR Axis Promotes Immune-Protective IL-17A Foxp3 Cells During Mucosal Infection and Is Dysregulated With Aging.
Thymus involution sets the clock of declined immunity and repair with aging.
Food insecurity and T-cell dysregulation in women living with HIV on antiretroviral therapy.
Rapamycin Eyedrops Increased CD4 Foxp3 Cells and Prevented Goblet Cell Loss in the Aged Ocular Surface.
Antioxidants N-Acetylcysteine and Vitamin C Improve T Cell Commitment to Memory and Long-Term Maintenance of Immunological Memory in Old Mice.
Evolution of comorbidities in people living with HIV between 2004 and 2014: cross-sectional analyses from ANRS CO3 Aquitaine cohort.
Impact of age on CD4 recovery and viral suppression over time among adults living with HIV who initiated antiretroviral therapy in the African Cohort Study.
hPMSCs protects against D-galactose-induced oxidative damage of CD4 T cells through activating Akt-mediated Nrf2 antioxidant signaling.
Substantial gap in primary care: older adults with HIV presenting late to care.
Quantitative Digitography Measures Fine Motor Disturbances in Chronically Treated HIV Similar to Parkinson's Disease.
Monocyte and T Cell Immune Phenotypic Profiles Associated With Age Advancement Differ Between People With HIV, Lifestyle-Comparable Controls and Blood Donors.
HIV and three dimensions of Wisdom: Association with cognitive function and physical and mental well-being: For: Psychiatry Research.
CD8 T cells are present at low levels in the white matter with physiological and pathological aging.
Immunotherapy in older patients with cancer.
Multiple genetic programs contribute to CD4 T cell memory differentiation and longevity by maintaining T cell quiescence.
Conventional Treatment for Multiple Myeloma Drives Premature Aging Phenotypes and Metabolic Dysfunction in T Cells.
Immunosenescence: the role of age in multiple sclerosis.
Umbilical cord mesenchymal stem cells protect thymus structure and function in aged C57 mice by downregulating aging-related genes and upregulating autophagy- and anti-oxidative stress-related genes.
Impaired Cytotoxic CD8 T Cell Response in Elderly COVID-19 Patients.
MeSH Terms
- Aged, 80 and over
- Antigens, CD
- Betacoronavirus
- CD4-Positive T-Lymphocytes
- CD8-Positive T-Lymphocytes
- COVID-19
- Coronavirus Infections
- Cytotoxins
- Female
- Humans
- Immunity, Cellular
- Male
- Middle Aged
- Pandemics
- Pneumonia, Viral
- SARS-CoV-2
- T-Lymphocyte Subsets
- T-Lymphocytes, Cytotoxic
Keywords
- CD4+
- CD8+
- COVID-19
- PD-1
- SARS-CoV-2
- aging
- cytotoxic T cells
- granzyme
- perforin
What are the roles of antibodies versus a durable, high quality T-cell response in protective immunity against SARS-CoV-2?
Per2 Upregulation in Circulating Hematopoietic Progenitor Cells During Chronic HIV Infection.
COVID-19: age, Interleukin-6, C-reactive protein, and lymphocytes as key clues from a multicentre retrospective study.
Immunosenescence profiles are not associated with muscle strength, physical performance and sarcopenia risk in very old adults: The Newcastle 85+ Study.
Homeostasis and the functional roles of CD4 Treg cells in aging.
A Comprehensive Evaluation of the Impact of Bovine Milk Containing Different Beta-Casein Profiles on Gut Health of Ageing Mice.
Premature aging of circulating T cells predicts all-cause mortality in hemodialysis patients.
In-depth immune cellular profiling reveals sex-specific associations with frailty.
CD70 contributes to age-associated T cell defects and overwhelming inflammatory responses.
Comparison of Overall and Comorbidity-Free Life Expectancy Between Insured Adults With and Without HIV Infection, 2000-2016.
Comparative Analysis of Age-Related Changes in Lacrimal Glands and Meibomian Glands of a C57BL/6 Male Mouse Model.
Thymus aging in mice deficient in either EphB2 or EphB3, two master regulators of thymic epithelium development.
CD8 T-cell senescence and skewed lymphocyte subsets in young Dyskeratosis Congenita patients with PARN and DKC1 mutations.
Short-Term Environmental Enrichment is a Stronger Modulator of Brain Glial Cells and Cervical Lymph Node T Cell Subtypes than Exercise or Combined Exercise and Enrichment.
Viral and host factors related to the clinical outcome of COVID-19.
MeSH Terms
- Adolescent
- Adult
- Aged
- Aged, 80 and over
- Aging
- Animals
- Asymptomatic Infections
- Betacoronavirus
- COVID-19
- China
- Cohort Studies
- Coronavirus Infections
- Critical Illness
- Disease Progression
- Evolution, Molecular
- Female
- Genetic Variation
- Genome, Viral
- Hospitalization
- Host-Pathogen Interactions
- Humans
- Inflammation Mediators
- Interleukin-6
- Interleukin-8
- Lymphocyte Count
- Lymphopenia
- Male
- Middle Aged
- Pandemics
- Phylogeny
- Pneumonia, Viral
- Respiratory Distress Syndrome
- SARS-CoV-2
- T-Lymphocytes
- Time Factors
- Treatment Outcome
- Virulence
- Virus Shedding
- Young Adult
- Zoonoses
Use of comedications and potential drug-drug interactions in people living with HIV in China.
CD4 T helper 17 cell response of aged mice promotes prostate cancer cell migration and invasion.
MeSH Terms
- Aging
- Animals
- CD4-Positive T-Lymphocytes
- Cell Differentiation
- Cell Line, Tumor
- Cell Movement
- Humans
- Inflammation
- Male
- Mice
- Mice, Inbred C57BL
- Mice, Knockout
- Models, Animal
- NF-kappa B
- Neoplasm Invasiveness
- PC-3 Cells
- Prostatic Neoplasms
- Th17 Cells
Keywords
- CD4+ T cell-secreted factors
- PCa cells
- Th17 cytokines
- aging
- inflammation
The Rules of Human T Cell Fate [i]in vivo[/i].
CD4/CD8 ratio, comorbidities, and aging in treated HIV infected individuals on viral suppression.
The effects of advanced maternal age on T-cell subsets at the maternal-fetal interface prior to term labor and in the offspring: a mouse study.
Structural and Functional Changes in the Mesenteric Lymph Nodes in Humans during Aging.
Neurocognitive Functioning is Associated with Self-Reported and Performance-Based Treatment Management Abilities in People Living with HIV with Low Health Literacy.
Blockade of Stat3 oncogene addiction induces cellular senescence and reveals a cell-nonautonomous activity suitable for cancer immunotherapy.
Age-related changes in T lymphocytes of patients with head and neck squamous cell carcinoma.
Immunological history governs human stem cell memory CD4 heterogeneity via the Wnt signaling pathway.
Estimating HIV Management and Comorbidity Costs Among Aging HIV Patients in the United States: A Systematic Review.
Sex Differences in People Aging With HIV.
Identification of Differentially Expressed miRNAs in the Response of Spleen CD4 T Cells to Electroacupuncture in Senescence-Accelerated Mice.
MeSH Terms
- Aging
- Animals
- Antagomirs
- CD4-Positive T-Lymphocytes
- Cell Differentiation
- Cytokines
- Down-Regulation
- Electroacupuncture
- Female
- Gene Regulatory Networks
- High-Throughput Nucleotide Sequencing
- Male
- Mice
- Mice, Inbred C57BL
- MicroRNAs
- Sequence Analysis, RNA
- Spleen
- Up-Regulation
Keywords
- CD4+ T cell
- Deep sequencing
- Electroacupuncture
- Immunological aging
- miRNA
Thymus Involution and Intravenous Drug Abuse.
Depletion of CD4 T cells provides therapeutic benefits in aged mice after ischemic stroke.
Immunological and Virological Responses in Older HIV-Infected Adults Receiving Antiretroviral Therapy: An Evidence-Based Meta-Analysis.
African Mitochondrial DNA Haplogroup L2 Is Associated With Slower Decline of β-cell Function and Lower Incidence of Diabetes Mellitus in Non-Hispanic, Black Women Living With Human Immunodeficiency Virus.
DP1 Activation Reverses Age-Related Hypertension Via NEDD4L-Mediated T-Bet Degradation in T Cells.
MeSH Terms
- Aged
- Aging
- Animals
- Antihypertensive Agents
- CD4-Positive T-Lymphocytes
- Cyclic AMP-Dependent Protein Kinases
- Cytokines
- Humans
- Hypertension
- Mice
- Mice, Inbred C57BL
- Nedd4 Ubiquitin Protein Ligases
- Prostaglandin D2
- Receptors, Prostaglandin
- Signal Transduction
- Sp1 Transcription Factor
- Superoxides
- T-Box Domain Proteins
- Th1 Cells
- Ubiquitination
Keywords
- D-prostanoid receptor 1
- aging
- hypertension
- lymphocyte
- prostaglandin (PG) D2
An Emerging Concern-High Rates of Frailty among Middle-aged and Older Individuals Living with HIV.
Higher Acuity Resource Utilization With Older Age and Poorer HIV Control in Adolescents and Young Adults in the HIV Research Network.
Mitochondrial DNA Haplogroups and Frailty in Adults Living with HIV.
Gallic acid attenuates thymic involution in the d-galactose induced accelerated aging mice.
Mitochondrial mass governs the extent of human T cell senescence.
MeSH Terms
- Adenosine Triphosphate
- Adult
- CD4-Positive T-Lymphocytes
- CD8-Positive T-Lymphocytes
- Cell Movement
- Cell Proliferation
- Cellular Senescence
- Glucose
- Glycolysis
- Humans
- Immunosenescence
- Leukocyte Common Antigens
- Microscopy, Electron, Transmission
- Middle Aged
- Mitochondria
- Rotenone
Keywords
- T cell
- aging
- metabolism
- mitochondria
- senescence
T cells and immune functions of plasma extracellular vesicles are differentially modulated from adults to centenarians.
Defects in Antiviral T Cell Responses Inflicted by Aging-Associated miR-181a Deficiency.
MeSH Terms
- Aging
- Animals
- CD4-Positive T-Lymphocytes
- CD8-Positive T-Lymphocytes
- Disease Models, Animal
- Lymphocytic Choriomeningitis
- Lymphocytic choriomeningitis virus
- Mice
- MicroRNAs
Keywords
- CD8 effector T cell
- T cell repertoire
- antiviral response
- immune aging
- immunosenescence
- microRNA
Increased Prevalence of Neurocognitive Impairment in Aging People Living With Human Immunodeficiency Virus: The ANRS EP58 HAND 55-70 Study.
Age-associated changes in human CD4 T cells point to mitochondrial dysfunction consequent to impaired autophagy.
Sex Differences in the Blood Transcriptome Identify Robust Changes in Immune Cell Proportions with Aging and Influenza Infection.
Going Beyond Giving Antiretroviral Therapy: Multimorbidity in Older People Aging with HIV in Nigeria.
Alterations in composition of immune cells and impairment of anti-tumor immune response in aged oral cancer-bearing mice.
LTA1 is a safe, intranasal enterotoxin-based adjuvant that improves vaccine protection against influenza in young, old and B-cell-depleted (μMT) mice.
MeSH Terms
- Adjuvants, Immunologic
- Administration, Intranasal
- Aging
- Animals
- Antibodies
- Antibody Formation
- B-Lymphocytes
- CD4-Positive T-Lymphocytes
- Dose-Response Relationship, Immunologic
- Enterotoxins
- Female
- Immunity, Mucosal
- Immunization
- Inflammation
- Influenza A Virus, H1N1 Subtype
- Lung
- Lymphocyte Activation
- Lymphocyte Depletion
- Mast Cells
- Mice, Inbred C57BL
- Orthomyxoviridae Infections
Thymus Imaging Detection and Size Is Inversely Associated With Metabolic Syndrome and Frailty in People With HIV.
Alterations in peripheral T cell and B cell subsets in patients with osteoarthritis.
Short Communication: Carotid Intima-Media Thickness Is Not Associated with Neurocognitive Impairment Among People Older than 50 Years With and Without HIV Infection from Thailand.
MeSH Terms
- Aging
- Anti-Retroviral Agents
- Cardiovascular Diseases
- Carotid Intima-Media Thickness
- Cross-Sectional Studies
- Depression
- Female
- HIV Infections
- Humans
- Male
- Middle Aged
- Neurocognitive Disorders
- Quality of Life
- Risk Factors
- Thailand
Keywords
- HIV
- aging
- carotid intima-media thickness
- neurocognitive
Implications of Immune Checkpoint Expression During Aging in HIV-Infected People on Antiretroviral Therapy.
MeSH Terms
- Adult
- Aged
- Aging
- Anti-HIV Agents
- Antiretroviral Therapy, Highly Active
- CD4-Positive T-Lymphocytes
- CD8-Positive T-Lymphocytes
- Cytokines
- Female
- Flow Cytometry
- Gene Expression
- HIV Infections
- HIV-1
- Hepatitis A Virus Cellular Receptor 2
- Humans
- Leukocytes, Mononuclear
- Male
- Middle Aged
- Young Adult
- gag Gene Products, Human Immunodeficiency Virus
Keywords
- aging
- immune checkpoint molecules
- virus suppression
Age-related alterations in human gut CD4 T cell phenotype, T helper cell frequencies, and functional responses to enteric bacteria.
Determinants of blood telomere length in antiretroviral treatment-naïve HIV-positive participants enrolled in the NEAT 001/ANRS 143 clinical trial.
MeSH Terms
- Adult
- Aged
- Anti-Retroviral Agents
- Cross-Sectional Studies
- Darunavir
- Emtricitabine
- Female
- HIV Infections
- Humans
- Logistic Models
- Male
- Middle Aged
- RNA, Viral
- Raltegravir Potassium
- Ritonavir
- Telomere
- Tenofovir
Keywords
- HIV infection
- aging
- immunosenescence
- telomere length
- viral load
Human T Cell Differentiation Negatively Regulates Telomerase Expression Resulting in Reduced Activation-Induced Proliferation and Survival.
Short Communication: Getting Older with HIV: Increasing Frequency of Comorbidities and Polypharmacy in Brazilian HIV Patients.
Gait Speed Decline Is Associated with Hemoglobin A1C, Neurocognitive Impairment, and Black Race in Persons with HIV.
MeSH Terms
- Adult
- African Americans
- Aging
- CD4 Lymphocyte Count
- Cohort Studies
- Female
- Glycated Hemoglobin A
- HIV Infections
- Humans
- Longitudinal Studies
- Male
- Middle Aged
- Neurocognitive Disorders
- Odds Ratio
- RNA, Viral
- Risk Factors
- Walking Speed
Keywords
- aging
- gait speed
- hemoglobin A1C
- neurocognitive impairment
Noncommunicable Diseases Burden and Risk Factors in a Cohort of HIV+ Elderly Patients in Malawi.
MeSH Terms
- Adult
- Age Factors
- Aged
- Anti-HIV Agents
- Anti-Retroviral Agents
- CD4 Lymphocyte Count
- Comorbidity
- Cost of Illness
- Cross-Sectional Studies
- Diabetes Mellitus
- Female
- HIV Infections
- Humans
- Hypertension
- Malawi
- Male
- Middle Aged
- Noncommunicable Diseases
- Odds Ratio
- Prevalence
- Retrospective Studies
- Risk Factors
Keywords
- HIV infection
- Malawi
- aging
- noncommunicable diseases
Aging promotes reorganization of the CD4 T cell landscape toward extreme regulatory and effector phenotypes.
Prevalence of hypertension and cardiovascular risk factors among long-term AIDS survivors: A report from the field.
MeSH Terms
- Acquired Immunodeficiency Syndrome
- Adult
- Anti-Retroviral Agents
- CD4 Lymphocyte Count
- Cardiovascular Diseases
- Diabetes Mellitus
- Diagnostic Screening Programs
- Female
- HIV Infections
- HIV-1
- Haiti
- Humans
- Hypercholesterolemia
- Hypertension
- Male
- Middle Aged
- Obesity
- Prevalence
- Retrospective Studies
- Risk Factors
- Smoking
- Survivors
Keywords
- HIV
- aging
- cardiovascular disease
- hypertension
- risk assessment
CD44
Hyaluronan goes to great length.
Naked mole-rat very-high-molecular-mass hyaluronan exhibits superior cytoprotective properties.
MeSH Terms
- Animals
- Apoptosis
- Cell Cycle Checkpoints
- Cell Line
- Cytoprotection
- Gene Expression Regulation
- Gene Knockout Techniques
- Humans
- Hyaluronan Receptors
- Hyaluronic Acid
- Longevity
- Mice
- Mole Rats
- Molecular Weight
- Primary Cell Culture
- Protein Interaction Maps
- RNA-Seq
- Signal Transduction
- Species Specificity
- Stress, Physiological
- Tumor Suppressor Protein p53
Maturity-dependent cartilage cell plasticity and sensitivity to external perturbation.
Aged Mice Exhibit Severe Exacerbations of Dry Eye Disease with an Amplified Memory Th17 Cell Response.
Chronic circadian misalignment accelerates immune senescence and abbreviates lifespan in mice.
Defective induction of the proteasome associated with T-cell receptor signaling underlies T-cell senescence.
MeSH Terms
- Animals
- CD4-Positive T-Lymphocytes
- Cell Proliferation
- Cells, Cultured
- Cellular Senescence
- Cytokines
- Hyaluronan Receptors
- Mice
- Mice, Inbred C57BL
- Phenotype
- Programmed Cell Death 1 Receptor
- Proteasome Endopeptidase Complex
- Receptors, Antigen, T-Cell
- Signal Transduction
Keywords
- T cell receptor signal
- T cell senescence
- aging
- proteasome
CD47
Aging-associated changes in CD47 arrangement and interaction with thrombospondin-1 on red blood cells visualized by super-resolution imaging.
CD47 Promotes Age-Associated Deterioration in Angiogenesis, Blood Flow and Glucose Homeostasis.
Unique Spatial Immune Profiling in Pancreatic Ductal Adenocarcinoma with Enrichment of Exhausted and Senescent T Cells and Diffused CD47-SIRPα Expression.
CD5
Comparative proteomic analysis identifies biomarkers for renal aging.
CD63
Cellular senescence contributes to age-dependent changes in circulating extracellular vesicle cargo and function.
CD68
Insulin activates microglia and increases COX-2/IL-1β expression in young but not in aged hippocampus.
Epigenetic modulation of macrophage polarization prevents lumbar disc degeneration.
Cellular senescence in recurrent tonsillitis and tonsillar hypertrophy in children.
Ginsenoside Rg1 supplementation clears senescence-associated β-galactosidase in exercising human skeletal muscle.
Histopathological, immunohistochemical, and molecular studies for determination of wound age and vitality in rats.
MeSH Terms
- Actins
- Animals
- Antigens, CD
- Antigens, Differentiation, Myelomonocytic
- Cell Movement
- Fibroblasts
- Granulation Tissue
- Immunohistochemistry
- Macrophages
- Models, Animal
- Neovascularization, Physiologic
- RNA, Messenger
- Rats, Wistar
- Re-Epithelialization
- Skin
- Time Factors
- Transforming Growth Factor beta1
- Vascular Endothelial Growth Factor A
- Wound Healing
- Wounds and Injuries
Keywords
- TGFb1
- VEGF
- gene expression
- immunohistochemistry
- wound aging
CD80
The aging common marmoset's immune system: From junior to senior.
CD81
Ovarian aging increases small extracellular vesicle CD81 release in human follicular fluid and influences miRNA profiles.
Older Adults with Physical Frailty and Sarcopenia Show Increased Levels of Circulating Small Extracellular Vesicles with a Specific Mitochondrial Signature.
Increased production of functional small extracellular vesicles in senescent endothelial cells.
CDA
Cumulative Dis/Advantage and Health Pattern in Late Life: A Comparison between Genders and Welfare State Regimes.
MeSH Terms
- Aged
- Aged, 80 and over
- China
- Cross-Sectional Studies
- England
- Female
- Health Behavior
- Health Status Disparities
- Humans
- Longevity
- Male
- Mexico
- Middle Aged
- Regression Analysis
- Self Report
- Sex Factors
- Social Class
- Social Welfare
- United States
Keywords
- Cumulative dis/advantage
- cross-national study
- health retirement study
- welfare state theory
Does numerical similarity alter age-related distractibility in working memory?
CDC20
Premature aging syndrome showing random chromosome number instabilities with CDC20 mutation.
CDC25A
Babam2 Regulates Cell Cycle Progression and Pluripotency in Mouse Embryonic Stem Cells as Revealed by Induced DNA Damage.
CDC42
Effects of age-dependent changes in cell size on endothelial cell proliferation and senescence through YAP1.
MeSH Terms
- Adaptor Proteins, Signal Transducing
- Adult
- Aging
- Animals
- Cell Cycle Proteins
- Cell Size
- Endothelial Cells
- Female
- Humans
- Male
- Mice, Inbred C57BL
- Middle Aged
- Neovascularization, Physiologic
- Primary Cell Culture
- Transcription Factors
- cdc42 GTP-Binding Protein
Keywords
- aging
- angiogenesis
- cell proliferation
- cell size
- senescence
CDH1
Cdc6 as a novel target in cancer: Oncogenic potential, senescence and subcellular localisation.
CDK1
MicroRNAomic Transcriptomic Analysis Reveal Deregulation of Clustered Cellular Functions in Human Mesenchymal Stem Cells During in Vitro Passaging.
MeSH Terms
- CDC2-CDC28 Kinases
- Cell Differentiation
- Cell Proliferation
- Cellular Senescence
- Cyclin B
- Gene Expression Regulation, Developmental
- Humans
- Mesenchymal Stem Cells
- MicroRNAs
- Transcriptome
- Tumor Suppressor Protein p53
- Umbilical Cord
Keywords
- Cell proliferation
- Cell senescence
- Cellular ageing
- Human Mesenchymal stem / stromal cells
- miRNA-mRNA integration
CDK2
p57 is a master regulator of human adipose derived stem cell quiescence and senescence.
CDK4
Emerging Roles for the [i]INK4a/ARF[/i] ([i]CDKN2A[/i]) Locus in Adipose Tissue: Implications for Obesity and Type 2 Diabetes.
Guilu Erxian Glue () Inhibits Chemotherapy-Induced Bone Marrow Hematopoietic Stem Cell Senescence in Mice May via p16 -Rb Signaling Pathway.
CDK5
Age-related hyperinsulinemia leads to insulin resistance in neurons and cell-cycle-induced senescence.
MeSH Terms
- Aging
- Animals
- Cell Cycle
- Cell Death
- Cellular Senescence
- Cyclin-Dependent Kinase 5
- Excitatory Postsynaptic Potentials
- Gene Expression
- Glycolysis
- Hexokinase
- Hyperinsulinism
- Inhibitory Postsynaptic Potentials
- Insulin
- Insulin Resistance
- Liraglutide
- Male
- Maze Learning
- Metformin
- Mice
- Neurons
- Phosphotransferases
- Primary Cell Culture
- Protein-Serine-Threonine Kinases
- Ubiquitination
- beta Catenin
CDK6
Saturated Fatty Acids Promote Hepatocytic Senecence through Regulation of miR-34a/Cyclin-Dependent Kinase 6.
Hepatoprotective effects of hydroxysafflor yellow A in D-galactose-treated aging mice.
Anti-cell growth and anti-cancer stem cell activity of the CDK4/6 inhibitor palbociclib in breast cancer cells.
Compromising the constitutive p16 expression sensitizes human neuroblastoma cells to Hsp90 inhibition and promotes premature senescence.
CDKN1A
Involvement of CDKN1A (p21) in cellular senescence in response to heat and irradiation stress during preimplantation development.
CDKN2A
Association between Nrf2 and CDKN2A expression in patients with end-stage renal disease: a pilot study.
CDKN2B
CFI
Psychosocial Resources for Hedonic Balance, Life Satisfaction and Happiness in the Elderly: A Path Analysis.
Validity and Reliability of the Flourishing Scale in a Sample of Older Adults in Iran.
The decision about retirement: A scale to describe representations and practices of medical doctors and nurses.
Family versus intimate partners: Estimating who matters more for health in a 20-year longitudinal study.
Adapting and validating the Rosenberg Self-Esteem Scale for elderly Spanish population.
CFTR
Exercise Physiology Across the Lifespan in Cystic Fibrosis.
Reduced expression of the Ion channel CFTR contributes to airspace enlargement as a consequence of aging and in response to cigarette smoke in mice.
CGA
Safety and efficacy of preoperative chemoradiotherapy in fit older patients with intermediate or locally advanced rectal cancer evaluated by comprehensive geriatric assessment: A planned interim analysis of a multicenter, phase II trial.
The Protective Effect of Chlorogenic Acid on Vascular Senescence via the Nrf2/HO-1 Pathway.
Association between comprehensive geriatric assessment and short-term outcomes among older adult patients with stroke: A nationwide retrospective cohort study using propensity score and instrumental variable methods.
Interventions to Improve Clinical Outcomes in Older Adults Admitted to a Surgical Service: A Systematic Review and Meta-analysis.
A Computerized Frailty Assessment Tool at Points-of-Care: Development of a Standalone Electronic Comprehensive Geriatric Assessment/Frailty Index (eFI-CGA).
Allocating patients to geriatric medicine wards in a tertiary university hospital in England: A service evaluation of the Specialist Advice for the Frail Elderly (SAFE) team.
Role of Frailty on Risk Stratification in Cardiac Surgery and Procedures.
MeSH Terms
- Aged
- Aged, 80 and over
- Cardiac Surgical Procedures
- Frail Elderly
- Frailty
- Geriatric Assessment
- Humans
- Percutaneous Coronary Intervention
- Risk Assessment
- Transcatheter Aortic Valve Replacement
Keywords
- Cardiac surgery
- Comprehensive geriatric assessment
- Disability
- Elderly
- Frailty
- Geriatrics
- Surgical risk scores
- TAVI
Developing an objective structured clinical examination in comprehensive geriatric assessment - A pilot study.
MeSH Terms
- Aged
- Clinical Competence
- Education, Medical, Graduate
- Educational Measurement
- Female
- Geriatric Assessment
- Geriatrics
- Humans
- Male
- Pilot Projects
- United Kingdom
Keywords
- Comprehensive geriatric assessment
- development
- entrustable professional capabilities
- objective structured clinical examination
- summative assessment
How do doctors choose treatment for older gynecological cancer patients? A Japanese Gynecologic Oncology Group survey of gynecologic oncologists.
Validation of the Pictorial Fit-Frail Scale in a memory clinic setting.
Impact of Resolution of Hyponatremia on Neurocognitive and Motor Performance in Geriatric Patients.
Health outcome of older hospitalized patients in internal medicine environments evaluated by Identification of Seniors at Risk (ISAR) screening and geriatric assessment.
MeSH Terms
- Accidental Falls
- Aged
- Aged, 80 and over
- Cohort Studies
- Emergency Service, Hospital
- Female
- Geriatric Assessment
- Health Status
- Hospitalization
- Humans
- Internal Medicine
- Length of Stay
- Male
- Mass Screening
- Patient Discharge
- Risk Assessment
Keywords
- CGA
- Cutoff
- Geriatrics
- ISAR
- Internal medicine
- Older in-patients
- Risk screening
- Sensitivity
- Specificity
CHI3L1
Postsynaptic damage and microglial activation in AD patients could be linked CXCR4/CXCL12 expression levels.
CHRNA7
Associations between genetic variations and global motion perception.
MeSH Terms
- Adult
- Differential Threshold
- Female
- Genotype
- Humans
- Male
- Motion Perception
- Polymorphism, Single Nucleotide
- Receptors, Nicotinic
- Sensory Thresholds
- Young Adult
- alpha7 Nicotinic Acetylcholine Receptor
Keywords
- Aging
- CHRNA7
- Cholinergic system
- Coherent motion
- Genetic variations
CHSY1
Loss of Chondroitin Sulfate Modification Causes Inflammation and Neurodegeneration in [i]skt[/i] Mice.
MeSH Terms
- Age Factors
- Animals
- Apoptosis
- Chondroitin Sulfates
- Female
- Glucuronosyltransferase
- Inflammation
- Male
- Mice
- Mice, Inbred C57BL
- Mice, Knockout
- Multifunctional Enzymes
- Mutation
- N-Acetylgalactosaminyltransferases
- Neurodegenerative Diseases
- Neurons
- Protein Processing, Post-Translational
- Proteins
- Retinal Degeneration
Keywords
- aging
- chondroitin sulfate synthase
- hippocampus
- inflammation
- mouse
- myeloid cells
- neurodegeneration
- retina
- retinal pigment epithelium
- subretinal space
CISD2
CISD2 Attenuates Inflammation and Regulates Microglia Polarization in EOC Microglial Cells-As a Potential Therapeutic Target for Neurodegenerative Dementia.
CIT
Effect of sex on aging-related decline of dopamine transporter in healthy subjects.
The Relationship Between the Striatal Dopaminergic Neuronal and Cognitive Function With Aging.
CLEC3B
CLEC3B p.S106G Mutant in a Caucasian Population of Successful Neurological Aging.
COL1A1
Remodeling process in bone of aged rats in response to resistance training.
COL3A1
Different expression of Defensin-B gene in the endometrium of mares of different age during the breeding season.
COMT
The geriatric pain experience in mice: intact cutaneous thresholds but altered responses to tonic and chronic pain.
MeSH Terms
- Acetone
- Aging
- Animals
- Behavior
- Biogenic Monoamines
- Capsaicin
- Chronic Pain
- Disease Models, Animal
- Male
- Mice, Inbred C57BL
- Peripheral Nerve Injuries
- Physical Stimulation
- Prefrontal Cortex
- Sensory Thresholds
Keywords
- Geriatric pain
- Healthy aging
- Mice
- Sensory thresholds
- Supraspinal plasticity
- Tonic and chronic pain response
COPE
Patterns and characteristics of cognitive functioning in older patients approaching end stage kidney disease, the COPE-study.
CORT
Sex differences in body composition, metabolism-related hormones, and energy homeostasis during aging in Wistar rats.
Effects of age and social isolation on murine hippocampal biochemistry and behavior.
Interleukin 6 reduces allopregnanolone synthesis in the brain and contributes to age-related cognitive decline in mice.
Sex- and age-dependent differences in the hormone and drinking responses to water deprivation.
Ontogeny of the adrenocortical response in an extremely altricial bird.
MeSH Terms
- Adrenal Glands
- Aging
- Animals
- Corticosterone
- Female
- Hypothalamo-Hypophyseal System
- Male
- Parrots
- Restraint, Physical
- Stress, Physiological
Keywords
- Venezuela
- adrenocortical
- altricial
- birds
- corticosterone
- glucocorticoid
- hypothalamic-pituitary-adrenal axis
- ontogeny
- parrots
- stress
CP
A Life Course Perspective on Growing Older With Cerebral Palsy.
The molecular anatomy and functions of the choroid plexus in healthy and diseased brain.
The effects and mechanism of collagen peptide and elastin peptide on skin aging induced by D-galactose combined with ultraviolet radiation.
Model based strategies towards protein A resin lifetime optimization and supervision.
MeSH Terms
- Algorithms
- Chromatography
- Kinetics
- Least-Squares Analysis
- Ligands
- Models, Theoretical
- Principal Component Analysis
- Resins, Plant
- Staphylococcal Protein A
- Statistics as Topic
Keywords
- Cleaning procedures
- Hybrid modeling
- Multivariate data analysis
- Protein A chromatography
- Resin aging
- Resin lifetime
The influence of age and environmental conditions on supplement intake by beef cattle winter grazing northern mixed-grass rangelands.
Cyclophosphamide, a cancer chemotherapy drug-induced early onset of reproductive senescence and alterations in reproductive performance and their prevention in mice.
Asymptomatic [i]Clostridium perfringens[/i] Inhabitation in Intestine Can Cause Inflammation, Apoptosis, and Disorders in Brain.
MeSH Terms
- Aging
- Animals
- Apoptosis
- Asymptomatic Infections
- Brain
- Brain Diseases
- Clostridium Infections
- Clostridium perfringens
- Disease Models, Animal
- Feces
- Food Microbiology
- Gene Expression
- Humans
- Inflammation
- Intestines
- Liver
- Male
- Mice
- Mice, Inbred C57BL
- Organ Size
- Oxidative Stress
- Risk Factors
- Spleen
Keywords
- Clostridium perfringens
- brain damage
- brain disorder
- gut microbiota
The Role of the Clinical Pharmacist in the Management of People Living with HIV in the Modern Antiretroviral Era.
MeSH Terms
- Aged
- Aged, 80 and over
- Anti-Retroviral Agents
- Disease Management
- Disease Transmission, Infectious
- Female
- HIV Infections
- Humans
- Male
- Medication Adherence
- Middle Aged
- Pharmacists
- Professional Role
- Treatment Outcome
Keywords
- Aging
- Antiretroviral therapy
- Clinical pharmacist
- Comorbidities
- HIV
A clinically feasible method for the assessment and characterization of pain in patients with chronic pancreatitis.
Differences in geometric strength at the contralateral hip between men with hip fracture and non-fractured comparators.
Factors associated with the number of clinical pharmacy recommendations: findings from an observational study in geriatric inpatients.
Protection against oxidative stress and anti-aging effect in Drosophila of royal jelly-collagen peptide.
CPM
Test-Retest Instability of Temporal Summation and Conditioned Pain Modulation Measures in Older Adults.
Age does not affect sex effect of conditioned pain modulation of pressure and thermal pain across 2 conditioning stimuli.
The Decline of Endogenous Pain Modulation With Aging: A Meta-Analysis of Temporal Summation and Conditioned Pain Modulation.
CPNE1
Prevalent intron retention fine-tunes gene expression and contributes to cellular senescence.
CPT1A
Alteration of fatty acid oxidation by increased CPT1A on replicative senescence of placenta-derived mesenchymal stem cells.
CPT1C
Carnitine palmitoyltransferase 1C reverses cellular senescence of MRC-5 fibroblasts via regulating lipid accumulation and mitochondrial function.
Carnitine palmitoyltransferase 1C contributes to progressive cellular senescence.
CPT2
The phytochemical epigallocatechin gallate prolongs the lifespan by improving lipid metabolism, reducing inflammation and oxidative stress in high-fat diet-fed obese rats.
CR1
Single Nucleotide Polymorphisms in Alzheimer's Disease Risk Genes Are Associated with Intrinsic Connectivity in Middle Age.
The whale shark genome reveals how genomic and physiological properties scale with body size.
CRABP2
Preconception resveratrol intake against infertility: Friend or foe?
CRBN
Using proteolysis-targeting chimera technology to reduce navitoclax platelet toxicity and improve its senolytic activity.
CRP
Omega-3 supplementation improves isometric strength but not muscle anabolic and catabolic signaling in response to resistance exercise in healthy older adults.
Circulating angiopoietin-like protein 2 levels and arterial stiffness in patients receiving maintenance hemodialysis: A cross-sectional study.
Cardiovascular rehabilitation in patients aged 70-year-old or older: benefits on functional capacity, physical activity and metabolic profile in younger [i]vs[/i]. older patients.
rRT-PCR Results of a Covid-19 Diagnosed Geriatric Patient.
The Association of Aging Biomarkers, Interstitial Lung Abnormalities, and Mortality.
A Novel Fortified Dairy Product and Sarcopenia Measures in Sarcopenic Older Adults: A Double-Blind Randomized Controlled Trial.
Age-Related Colonic Mucosal Microbiome Community Shifts in Monkeys.
The relationship between frailty and serum alpha klotho levels in geriatric patients.
ZMPSTE24 Is Associated with Elevated Inflammation and Progerin mRNA.
Cultural and life style practices associated with low inflammatory physiology in Japanese adults.
Moderate- to high intensity aerobic and resistance exercise reduces peripheral blood regulatory cell populations in older adults with rheumatoid arthritis.
PTSD and the klotho longevity gene: Evaluation of longitudinal effects on inflammation via DNA methylation.
Bereavement is associated with reduced systemic inflammation: C-reactive protein before and after widowhood.
The Impact of Age on the Prevalence of Sarcopenic Obesity in Bariatric Surgery Candidates.
Intake of dietary advanced glycation end products influences inflammatory markers, immune phenotypes, and antiradical capacity of healthy elderly in a little-studied population.
Intentional Switching Between Bimanual Coordination Patterns in Older Adults: Is It Mediated by Inhibition Processes?
Shorter Telomere Length in Peripheral Blood Leukocytes Is Associated with Post-Traumatic Chronic Osteomyelitis.
Risk Factors of Progression to Frailty: Findings from the Singapore Longitudinal Ageing Study.
MeSH Terms
- Aged
- Aged, 80 and over
- Aging
- Disease Progression
- Female
- Frail Elderly
- Frailty
- Geriatric Assessment
- Humans
- Independent Living
- Longitudinal Studies
- Male
- Nutrition Assessment
- Nutritional Status
- Physical Examination
- Risk Factors
- Singapore
- Socioeconomic Factors
Keywords
- Frailty
- longitudinal
- risk factors
- transition
Physical Function and Strength in Relation to Inflammation in Older Adults with Obesity and Increased Cardiometabolic Risk.
Key diagnostic characteristics of fever of unknown origin in Japanese patients: a prospective multicentre study.
Decrease in Serum Vitamin D Level of Older Patients with Fatigue.
The Association between Frailty Indicators and Blood-Based Biomarkers in Early-Old Community Dwellers of Thailand.
MeSH Terms
- Aged
- Aged, 80 and over
- Biomarkers
- C-Reactive Protein
- CD4-CD8 Ratio
- Cross-Sectional Studies
- Female
- Frail Elderly
- Frailty
- Humans
- Independent Living
- Interleukin-6
- Male
- Middle Aged
- Thailand
Keywords
- C-reactive protein
- Thailand
- aging
- cross-sectional study
- frailty
- frailty biomarkers
- fried’s phenotypes
- interleukin-6
Associations of C-reactive protein and homocysteine concentrations with the impairment of intrinsic capacity domains over a 5-year follow-up among community-dwelling older adults at risk of cognitive decline (MAPT Study).
MeSH Terms
- Activities of Daily Living
- Aged
- Biomarkers
- Body Mass Index
- C-Reactive Protein
- Cognitive Dysfunction
- Depression
- Female
- Follow-Up Studies
- Geriatric Assessment
- Hand Strength
- Homocysteine
- Humans
- Independent Living
- Inflammation
- Male
- Mobility Limitation
- Neuropsychological Tests
- Prospective Studies
- Risk Factors
- Time Factors
Keywords
- Aging
- C-reactive protein
- Homocysteine
- Inflammation
- Intrinsic capacity
- Older adults
Longitudinal analysis of loneliness and inflammation at older ages: English longitudinal study of ageing.
The cortisol burden in elderly subjects with metabolic syndrome and its association with low-grade inflammation.
Recurrent circadian fasting (RCF) improves blood pressure, biomarkers of cardiometabolic risk and regulates inflammation in men.
MeSH Terms
- Adult
- Biomarkers
- Blood Pressure
- C-Reactive Protein
- Cardiovascular Diseases
- Circadian Rhythm
- Diet
- Energy Intake
- Fasting
- Heart Rate
- Humans
- Inflammation
- Male
- Metabolic Diseases
- Middle Aged
- Nutritional Physiological Phenomena
- Regression Analysis
- Risk Factors
- Young Adult
Keywords
- Aging
- Health benefits
- Inflammation
- Recurrent fasting
Characteristics of patients with rheumatoid arthritis undergoing primary total joint replacement: A 14-year trend analysis (2004-2017).
MeSH Terms
- Adult
- Aged
- Antirheumatic Agents
- Arthritis, Rheumatoid
- Arthroplasty, Replacement
- Arthroplasty, Replacement, Knee
- Biological Products
- Drug Utilization
- Female
- Humans
- Japan
- Male
- Middle Aged
- Postoperative Complications
Keywords
- C-reactive protein
- Rheumatoid arthritis
- aging
- arthroplasty
- drug therapy
CS
Acute effect of bodyweight-based strength training on blood pressure of hypertensive older adults: A randomized crossover clinical trial.
Particle growth with photochemical age from new particle formation to haze in the winter of Beijing, China.
Effect of aging on stabilization of Cd and Ni by biochars and enzyme activities in a historically contaminated alkaline agricultural soil simulated with wet-dry and freeze-thaw cycling.
Vision Impairment and Participation in Cognitively Stimulating Activities: The Health ABC Study.
Suspension training vs. traditional resistance training: effects on muscle mass, strength and functional performance in older adults.
Generational Differences in the 10-year Incidence of Impaired Contrast Sensitivity.
Inducible aging in Hydra oligactis implicates sexual reproduction, loss of stem cells, and genome maintenance as major pathways.
Noradrenergic Responsiveness Supports Selective Attention across the Adult Lifespan.
Cellular senescence: from anti-cancer weapon to anti-aging target.
MeSH Terms
- Aging
- Animals
- Antineoplastic Agents
- Breast Neoplasms
- Cell Proliferation
- Cell Transformation, Neoplastic
- Cellular Senescence
- Cyclin-Dependent Kinases
- Drug Discovery
- Female
- Humans
- Piperazines
- Protein Kinase Inhibitors
- Pyridines
Keywords
- cancer
- cellular senescence
- healthy aging
- pro-senescence cancer therapy
- senolytic therapies
Extra-mitochondrial citrate synthase initiates calcium oscillation and suppresses age-dependent sperm dysfunction.
Pathogenesis of chronic obstructive pulmonary disease (COPD) induced by cigarette smoke.
Possible Role of Amyloid Cross-Seeding in Evolvability and Neurodegenerative Disease.
MeSH Terms
- Aging
- Amyloidogenic Proteins
- Animals
- Biological Evolution
- Brain
- Female
- Humans
- Inheritance Patterns
- Models, Neurological
- Neurodegenerative Diseases
- Pregnancy
- Stress, Physiological
Keywords
- Alzheimer’s disease
- Parkinson’s disease
- amyloid cascade hypothesis
- amyloidogenic proteins
- antimicrobial protection model
- cross-seeding
- evolvability hypothesis
Targeting p16-induced senescence prevents cigarette smoke-induced emphysema by promoting IGF1/Akt1 signaling in mice.
MeSH Terms
- Alveolar Epithelial Cells
- Animals
- Cell Proliferation
- Cellular Senescence
- Cyclin-Dependent Kinase Inhibitor p16
- Cytokines
- Emphysema
- Insulin-Like Growth Factor I
- Lung
- Mice, Inbred C57BL
- Models, Biological
- Promoter Regions, Genetic
- Proto-Oncogene Proteins c-akt
- Pulmonary Disease, Chronic Obstructive
- RNA, Messenger
- Signal Transduction
- Smoking
Keywords
- Molecular biology
- Senescence
- Stem cells
CSF1R
CSF1R inhibitor PLX5622 and environmental enrichment additively improve metabolic outcomes in middle-aged female mice.
Modulation of Microglia by Voluntary Exercise or CSF1R Inhibition Prevents Age-Related Loss of Functional Motor Units.
MeSH Terms
- Aging
- Animals
- Cell Line
- Databases, Genetic
- Humans
- Induced Pluripotent Stem Cells
- Macrophages
- Male
- Mice
- Mice, Inbred C57BL
- Microglia
- Motor Neurons
- Muscle, Skeletal
- Neuromuscular Junction
- Neuronal Plasticity
- Physical Conditioning, Animal
- RNA-Seq
- Receptors, Granulocyte-Macrophage Colony-Stimulating Factor
- Spinal Cord
Keywords
- CSF1R inhibition
- aging
- exercise
- innervation
- microglia
- motor unit
- neuroinflammation
- neuromuscular junction
- neuromuscular system
- spinal cord
CTCF
New targeted approaches for epigenetic age predictions.
CTH
Anterior Cingulate Structure and Perfusion is Associated with Cerebrospinal Fluid Tau among Cognitively Normal Older Adult APOEɛ4 Carriers.
CTLA4
Horticultural Therapy Reduces Biomarkers of Immunosenescence and Inflammaging in Community-Dwelling Older Adults: A Feasibility Pilot Randomized Controlled Trial.
CTRL
Aging reduces the maximal level of peripheral fatigue tolerable and impairs exercise capacity.
miR-146a Plasma Levels Are Not Altered in Alzheimer's Disease but Correlate With Age and Illness Severity.
Centrally-mediated regulation of peripheral fatigue during knee extensor exercise and consequences on the force-duration relationship in older men.
CTSA
A CTSA-based consultation service to advance research on special and underserved populations.
CTSB
Myocardial cathepsin D is downregulated in sudden cardiac death.
CX3CL1
CX3CR1
Monocytes present age-related changes in phospholipid concentration and decreased energy metabolism.
Muscle Injury Induces Postoperative Cognitive Dysfunction.
CXCL1
Contusion spinal cord injury upregulates p53 protein expression in rat soleus muscle at multiple timepoints but not key senescence cytokines.
Systemic Inflammation and the Increased Risk of Inflamm-Aging and Age-Associated Diseases in People Living With HIV on Long Term Suppressive Antiretroviral Therapy.
MeSH Terms
- Adult
- Aging
- Anti-HIV Agents
- Antiretroviral Therapy, Highly Active
- Biomarkers
- CD4 Lymphocyte Count
- Computational Biology
- Cross-Sectional Studies
- Disease Susceptibility
- Duration of Therapy
- Female
- HIV Infections
- Humans
- Inflammation
- Male
- Metabolome
- Metabolomics
- Middle Aged
- Proteomics
- Telomere Homeostasis
- Viral Load
Keywords
- HIV
- India
- LMIC (lower middle income country)
- inflammation markers
- long term antiretroviral therapy
CXCL10
Age-related decline of interferon-gamma responses in macrophage impairs satellite cell proliferation and regeneration.
CXCL11
Endothelial cells under therapy-induced senescence secrete CXCL11, which increases aggressiveness of breast cancer cells.
CXCL12
Co-option of Neutrophil Fates by Tissue Environments.
Heme oxygenase-1 deficiency triggers exhaustion of hematopoietic stem cells.
Global Transcriptomic Profiling of the Bone Marrow Stromal Microenvironment during Postnatal Development, Aging, and Inflammation.
MeSH Terms
- Aging
- Animals
- Bone Marrow
- Bone Marrow Cells
- Cell Differentiation
- Cells, Cultured
- Cellular Microenvironment
- Chemokine CXCL12
- Embryonic Development
- Endothelial Cells
- Gene Expression Profiling
- Hematopoiesis
- Hematopoietic Stem Cells
- Inflammation
- Male
- Mesenchymal Stem Cells
- Mice
- Mice, Inbred C57BL
- Stem Cell Niche
- Transcriptome
Keywords
- aging
- bone marrow microenvironment
- hematopoietic stem cells
- inflammation
- niches
- stromal cells
- transcriptomics
CXCL13
RNA-seq data from C-X-C chemokine receptor type 5 (CXCR5) gene knockout aged mice with retinal degeneration phenotype.
CXCL14
Identification of genes associated with endometrial cell aging.
CXCL8
Cerebrovascular Senescence Is Associated With Tau Pathology in Alzheimer's Disease.
CXCL9
CXCL9 and CXCL10 display an age-dependent profile in Chagas patients: a cohort study of aging in Bambui, Brazil.
CXCR2
CXCL5-CXCR2 signaling is a senescence-associated secretory phenotype in preimplantation embryos.
Senescence in Wound Repair: Emerging Strategies to Target Chronic Healing Wounds.
CXCR3
Senescent hepatocytes enhance natural killer cell activity via the CXCL-10/CXCR3 axis.
CXCR4
Aging-Related Reduced Expression of CXCR4 on Bone Marrow Mesenchymal Stromal Cells Contributes to Hematopoietic Stem and Progenitor Cell Defects.
Transfer of a human gene variant associated with exceptional longevity improves cardiac function in obese type 2 diabetic mice through induction of the SDF-1/CXCR4 signalling pathway.
Stromal Cell-Derived Factor 1 Protects Brain Vascular Endothelial Cells from Radiation-Induced Brain Damage.
MeSH Terms
- Animals
- Blood Vessels
- Brain
- Cell Line
- Cellular Senescence
- Chemokine CXCL12
- Cranial Irradiation
- Disease Models, Animal
- Down-Regulation
- Endothelial Cells
- Female
- Gene Expression Regulation
- Humans
- Lipopeptides
- Mice
- Receptors, CXCR4
- Signal Transduction
Keywords
- CXCR4
- SDF-1
- brain disorder
- endothelial dysfunction
- ionizing radiation
- senescence
CYP11B1
Intratumoral heterogeneity of the tumor cells based on in situ cortisol excess in cortisol-producing adenomas; ∼An association among morphometry, genotype and cellular senescence∼.
CYP1A1
Genome-wide scan identified genetic variants associated with skin aging in a Chinese female population.
MeSH Terms
- Adult
- Aged
- Aged, 80 and over
- Asian Continental Ancestry Group
- Cheek
- Cohort Studies
- Cytochrome P-450 CYP1A1
- European Continental Ancestry Group
- Female
- Genome-Wide Association Study
- Humans
- Middle Aged
- Polymorphism, Single Nucleotide
- Risk Factors
- Skin Aging
- Skin Pigmentation
Keywords
- Candidate SNPs
- Chinese Han females
- GWAS
- Skin aging
CYP26B1
Increased Retinoic Acid Catabolism in Olfactory Sensory Neurons Activates Dormant Tissue-Specific Stem Cells and Accelerates Age-Related Metaplasia.
CYP2C19
Physiologically Based Pharmacokinetic Approach Can Successfully Predict Pharmacokinetics of Citalopram in Different Patient Populations.
Longitudinal exposure of English primary care patients to pharmacogenomic drugs: An analysis to inform design of pre-emptive pharmacogenomic testing.
MeSH Terms
- Aged
- Aged, 80 and over
- Aging
- Cytochrome P-450 CYP2C19
- Cytochrome P-450 CYP2D6
- Drug Prescriptions
- Female
- Humans
- Liver-Specific Organic Anion Transporter 1
- Longitudinal Studies
- Male
- Middle Aged
- Pharmaceutical Preparations
- Pharmacogenomic Testing
- Precision Medicine
- Primary Health Care
- United Kingdom
Keywords
- clinical pharmacology
- general practice
- pharmacogenomics
CYP2E1
DNA methylation and histone acetylation changes to cytochrome P450 2E1 regulation in normal aging and impact on rates of drug metabolism in the liver.
CYP7A1
Age-associated changes of cytochrome P450 and related phase-2 gene/proteins in livers of rats.
DBI
Quantifying cumulative anticholinergic and sedative drug load among US Medicare Beneficiaries.
Drug Burden Index and Cognitive and Physical Function in Aged Care Residents: A Longitudinal Study.
Using the Drug Burden Index to identify older adults at highest risk for medication-related falls.
Impact of STEADI-Rx: A Community Pharmacy-Based Fall Prevention Intervention.
DBP
Do baseline blood pressure and type of exercise influence level of reduction induced by training in hypertensive older adults? A meta-analysis of controlled trials.
Attenuated aortic blood pressure responses to metaboreflex activation in older adults with dynapenia.
The Effect of Blood Pressure on Cognitive Performance. An 8-Year Follow-Up of the Tromsø Study, Comprising People Aged 45-74 Years.
Low Diastolic Blood Pressure and Cognitive Decline in Korean Elderly People: The Korean Longitudinal Study on Cognitive Aging and Dementia.
Diastolic Blood Pressure Is Associated With Regional White Matter Lesion Load: The Northern Manhattan Study.
MeSH Terms
- Aged
- Arterial Pressure
- Blood Pressure
- Brain
- Cohort Studies
- Diastole
- Female
- Frontal Lobe
- Humans
- Hypertension
- Linear Models
- Magnetic Resonance Imaging
- Male
- Middle Aged
- Organ Size
- Parietal Lobe
- Prospective Studies
- Systole
- Temporal Lobe
- White Matter
Keywords
- American Heart Association
- blood pressure
- cerebrovascular disease
- cognitive aging
- white matter
Orthostatic Hypotension and Novel Blood Pressure Associated Gene Variants in Older Adults: Data From the TILDA Study.
Blood pressure and hypertension prevalence among oldest-old in China for 16 year: based on CLHLS.
The age-related blood pressure trajectories from young-old adults to centenarians: A cohort study.
DCC
X Chromosome Domain Architecture Regulates Caenorhabditis elegans Lifespan but Not Dosage Compensation.
MeSH Terms
- Adenosine Triphosphatases
- Animals
- Caenorhabditis elegans
- Caenorhabditis elegans Proteins
- DNA-Binding Proteins
- Dosage Compensation, Genetic
- Gene Expression Regulation
- Longevity
- Multiprotein Complexes
- X Chromosome
Keywords
- X chromosome dosage compensation
- aging
- condensin
- gene expression
- higher-order chromosome structure
- lifespan
- proteotoxic stress
- topologically associating domains
DCN
Decorin inhibits the insulin-like growth factor I signaling in bone marrow mesenchymal stem cells of aged humans.
DCX
GSK-3β activation accelerates early-stage consumption of Hippocampal Neurogenesis in senescent mice.
Doublecortin and IGF-1R protein levels are reduced in spite of unchanged DNA methylation in the hippocampus of aged rats.
DDB1
DCAF1 regulates Treg senescence via the ROS axis during immunological aging.
DDC
N-Acetyl Cysteine Attenuates the Sarcopenia and Muscle Apoptosis Induced by Chronic Liver Disease.
DDO
New insights on the influence of free d-aspartate metabolism in the mammalian brain during prenatal and postnatal life.
DDT
Prognostic Value of a Test of Central Auditory Function in Conversion from Mild Cognitive Impairment to Dementia.
Uptake kinetics of four hydrophobic organic pollutants in the earthworm Eisenia andrei in aged laboratory-contaminated natural soils.
Adult exposure to insecticides causes persistent behavioral and neurochemical alterations in zebrafish.
Second generation effects of larval metal pollutant exposure on reproduction, longevity and insecticide tolerance in the major malaria vector Anopheles arabiensis (Diptera: Culicidae).
Protective effect of Pedro-Ximénez must against p,p'-DDE-induced liver damages in aged Mus spretus mice.
MeSH Terms
- Aging
- Animals
- Antioxidants
- Chemical and Drug Induced Liver Injury
- Dichlorodiphenyl Dichloroethylene
- Down-Regulation
- Liver
- Male
- Mice
- Oxidative Stress
- Pesticides
- Plant Extracts
- Polyphenols
- Transcriptome
- Up-Regulation
- Vitis
Keywords
- Aging
- Hepatoprotection
- Mus spretus
- Organochlorine
- Oxidative damage
- Pedro-ximénez grape must
- Transcriptional analysis
- p,p'-DDE
Low-dose endosulfan inhibits proliferation and induces senescence and pro-inflammatory cytokine production in human lymphocytes, preferentially impacting cytotoxic cells.
MeSH Terms
- Adult
- B-Lymphocytes
- Cell Proliferation
- Cells, Cultured
- Cellular Senescence
- Cytokines
- Dose-Response Relationship, Drug
- Endosulfan
- Female
- Healthy Volunteers
- Humans
- Inflammation Mediators
- Insecticides
- Killer Cells, Natural
- Male
- Primary Cell Culture
- T-Lymphocytes, Cytotoxic
- Young Adult
Keywords
- Endosulfan
- Immunosenescence
- NK cells
- PBMC
- cytotoxic cells
- interferon
- organochlorine pesticide
- senescence
DKC1
Successful liver transplantation in short telomere syndromes without bone marrow failure due to DKC1 mutation.
DLD
A preliminary study of cerebral blood flow, aging and dementia in people with Down syndrome.
DLGAP2
Cross-Species Analyses Identify Dlgap2 as a Regulator of Age-Related Cognitive Decline and Alzheimer's Dementia.
DLX5
Inhibition of microRNA-27b-3p relieves osteoarthritis pain via regulation of KDM4B-dependent DLX5.
DMD
Aldehyde dehydrogenases contribute to skeletal muscle homeostasis in healthy, aging, and Duchenne muscular dystrophy patients.
Life expectancy at birth in Duchenne muscular dystrophy: a systematic review and meta-analysis.
Renal dysfunction can occur in advanced-stage Duchenne muscular dystrophy.
MeSH Terms
- Adolescent
- Adult
- Aging
- Child
- Child, Preschool
- Cystatin C
- Disease Progression
- Female
- Heart Diseases
- Heart Function Tests
- Humans
- Kidney Diseases
- Kidney Function Tests
- Male
- Muscular Dystrophy, Duchenne
- Risk Factors
- Young Adult
Keywords
- Duchenne muscular dystrophy
- advanced stage
- cystatin C
- ejection fraction
- fractional shortening
- renal dysfunction
DNAJB9
DNAJB9 Inhibits p53-Dependent Oncogene-Induced Senescence and Induces Cell Transformation.
DNMT1
DNA Methyltransferase 1 (DNMT1) Function Is Implicated in the Age-Related Loss of Cortical Interneurons.
DNMT3A
Epigenetic regulation of miR-29a/miR-30c/DNMT3A axis controls SOD2 and mitochondrial oxidative stress in human mesenchymal stem cells.
Collagens and DNA methyltransferases in mare endometrosis.
Age-related clonal haemopoiesis is associated with increased epigenetic age.
DNMT3L
Transient DNMT3L Expression Reinforces Chromatin Surveillance to Halt Senescence Progression in Mouse Embryonic Fibroblast.
DOCK11
[Immunosenescence: The Forefront of Infection and Trophic Control].
DPP4
Age-Dependent Assessment of Genes Involved in Cellular Senescence, Telomere, and Mitochondrial Pathways in Human Lung Tissue of Smokers, COPD, and IPF: Associations With SARS-CoV-2 COVID-19 ACE2-TMPRSS2-Furin-DPP4 Axis.
Dipeptidyl peptidase-4 inhibition improves endothelial senescence by activating AMPK/SIRT1/Nrf2 signaling pathway.
Molecular crosstalk between Y5 receptor and neuropeptide Y drives liver cancer.
DPP6
A novel structure associated with aging is augmented in the DPP6-KO mouse brain.
DPYSL2
Alcohol drinking exacerbates neural and behavioral pathology in the 3xTg-AD mouse model of Alzheimer's disease.
MeSH Terms
- Alcohol Drinking
- Alzheimer Disease
- Amyloid beta-Protein Precursor
- Animals
- Behavior, Animal
- Brain
- Disease Models, Animal
- Mice, Transgenic
- tau Proteins
Keywords
- Aging
- Amyloid beta
- Ethanol
- GSK
- Immunohistochemistry
- Morris Water Maze
- Prepulse inhibition
- Self-administration
- Tau pathology
- Transgenic mouse model
DRD1
Impact of dopamine-related genetic variants on physical activity in old age - a cohort study.
DRD2
Cortical thickness mediates the relationship between DRD2 C957T polymorphism and executive function across the adult lifespan.
The relationship of age and DRD2 polymorphisms to frontostriatal brain activity and working memory performance.
DSPP
Effects of [i]p[/i]-Cresol on Senescence, Survival, Inflammation, and Odontoblast Differentiation in Canine Dental Pulp Stem Cells.
DST
Ancestral germen/soma distinction in microbes: Expanding the disposable soma theory of aging to all unicellular lineages.
DUSP1
miR-1468-3p Promotes Aging-Related Cardiac Fibrosis.
DUSP8
MiR-21-5p/dual-specificity phosphatase 8 signalling mediates the anti-inflammatory effect of haem oxygenase-1 in aged intracerebral haemorrhage rats.
MeSH Terms
- Aging
- Animals
- Antagomirs
- Anti-Inflammatory Agents
- Cells, Cultured
- Cerebral Hemorrhage
- Dual-Specificity Phosphatases
- HEK293 Cells
- Heme Oxygenase-1
- Hemin
- Humans
- Male
- MicroRNAs
- Rats
- Rats, Sprague-Dawley
- Signal Transduction
Keywords
- aging
- dual-specificity phosphatase 8
- haem oxygenase-1
- intracerebral haemorrhage
- microRNA
DUT
Simultaneous liquefaction, saccharification, and fermentation of L-lactic acid using aging paddy rice with hull by an isolated thermotolerant Enterococcus faecalis DUT1805.
DYRK1A
Altered age-linked regulation of plasma DYRK1A in elderly cognitive complainers (INSIGHT-preAD study) with high brain amyloid load.
E2F1
Regulation of E2F1 activity via PKA-mediated phosphorylations.
Astragaloside IV ameliorates radiation-induced senescence via antioxidative mechanism.
ECD
Outcome of Descemet Membrane Endothelial Keratoplasty Using Corneas from Donors ≥80 Years of Age.
MeSH Terms
- Adolescent
- Adult
- Aged
- Aged, 80 and over
- Aging
- Cell Count
- Cornea
- Descemet Stripping Endothelial Keratoplasty
- Donor Selection
- Endothelium, Corneal
- Female
- Fuchs' Endothelial Dystrophy
- Humans
- Male
- Middle Aged
- Retrospective Studies
- Tissue Donors
- Treatment Outcome
- Visual Acuity
- Young Adult
EDA
Interplay between aging, lung inflammation/remodeling, and fibronectin EDA in lung cancer progression.
Arousal Detection in Elderly People from Electrodermal Activity Using Musical Stimuli.
The structure of agricultural microplastics (PT, PU and UF) and their sorption capacities for PAHs and PHE derivates under various salinity and oxidation treatments.
MeSH Terms
- Adsorption
- Agriculture
- Ecosystem
- Environmental Pollutants
- Hydrogen Peroxide
- Microplastics
- Models, Chemical
- Naphthalenes
- Organic Chemicals
- Phenanthrenes
- Plastics
- Polycyclic Aromatic Hydrocarbons
- Polyethylene
- Polypropylenes
- Polyurethanes
- Polyuria
- Pyrenes
- Salinity
Keywords
- Aging
- Microplastics
- Polycyclic aromatic hydrocarbons
- Salinity
- Sorption
EDARADD
Age prediction in living: Forensic epigenetic age estimation based on blood samples.
MeSH Terms
- Adolescent
- Adult
- Aged
- Aging
- Child
- Child, Preschool
- CpG Islands
- Cyclic Nucleotide Phosphodiesterases, Type 4
- DNA Methylation
- Edar-Associated Death Domain Protein
- Fatty Acid Elongases
- Female
- Forensic Genetics
- Humans
- Infant
- LIM-Homeodomain Proteins
- Male
- Middle Aged
- Muscle Proteins
- Polymerase Chain Reaction
- Transcription Factors
- Young Adult
Keywords
- Age the living
- CpGs
- DNA methylation age
- Forensic epigenetics
- Forensic sciences
EDF1
Silencing of FOREVER YOUNG FLOWER Like Genes from Phalaenopsis Orchids Promotes Flower Senescence and Abscission.
EFS
The aging bladder phenotype is not the direct consequence of bladder aging.
MeSH Terms
- Adrenergic beta-Agonists
- Aging
- Animals
- Carbachol
- Cholinergic Agonists
- Electric Stimulation
- Female
- Isoproterenol
- Male
- Mice
- Mucous Membrane
- Muscle Contraction
- Myography
- Phenotype
- Receptor, Muscarinic M3
- Receptors, Adrenergic, beta-2
- Urinary Bladder
- Urination
Keywords
- aging
- control physiology
- resilience
- urinary dysfunction
EGF
Acute, exercise-induced alterations in cytokines and chemokines in the blood distinguish physically active and sedentary aging.
Proinflammation, profibrosis, and arterial aging.
Hinokitiol induces cell death and inhibits epidermal growth factor-induced cell migration and signaling pathways in human cervical adenocarcinoma.
Activation of epidermal growth factor receptor signaling mediates cellular senescence induced by certain pro-inflammatory cytokines.
Insulin Signaling in Intestinal Stem and Progenitor Cells as an Important Determinant of Physiological and Metabolic Traits in [i]Drosophila[/i].
Different cellular properties and loss of nuclear signalling of porcine epidermal growth factor receptor with aging.
EGFR
Type I Collagen Aging Increases Expression and Activation of EGFR and Induces Resistance to Erlotinib in Lung Carcinoma in 3D Matrix Model.
Comparative effectiveness and cost-effectiveness of three first-line EGFR-tyrosine kinase inhibitors: Analysis of real-world data in a tertiary hospital in Taiwan.
An Optogenetic Method to Study Signal Transduction in Intestinal Stem Cell Homeostasis.
MeSH Terms
- Animals
- Cell Communication
- Cell Proliferation
- Cells, Cultured
- Drosophila Proteins
- Drosophila melanogaster
- Gene Expression Regulation
- Gene Regulatory Networks
- Homeostasis
- Intestinal Mucosa
- Light
- Longevity
- Optogenetics
- Signal Transduction
- Stem Cells
Keywords
- Drosophila
- EGFR
- Toll
- optogenetics
- stem cells
Treatment-Induced Tumor Dormancy through YAP-Mediated Transcriptional Reprogramming of the Apoptotic Pathway.
MeSH Terms
- Adaptor Proteins, Signal Transducing
- Animals
- Apoptosis
- Cell Cycle Proteins
- Cell Line, Tumor
- Cell Proliferation
- Cell Survival
- Cellular Senescence
- Drug Resistance, Neoplasm
- ErbB Receptors
- Female
- Gene Deletion
- Gene Expression Regulation, Neoplastic
- Humans
- Lung Neoplasms
- MAP Kinase Kinase 1
- Male
- Mice
- Mice, Knockout
- Mutation
- Signal Transduction
- Transcription Factors
- Transcription, Genetic
Keywords
- YAP
- dormancy
- drug resistance
- drug tolerance
- epidermal growth factor receptor
- lung cancer
- senescence
Association between EGFR mutation and ageing, history of pneumonia and gastroesophageal reflux disease among patients with advanced lung cancer.
MeSH Terms
- Adult
- Aged
- Aged, 80 and over
- Aging
- Case-Control Studies
- ErbB Receptors
- Female
- Gastroesophageal Reflux
- Humans
- Lung Neoplasms
- Male
- Middle Aged
- Mutation
- Pneumonia
- Republic of Korea
- Retrospective Studies
- Risk Factors
- Young Adult
Keywords
- Ageing
- EGFR mutation
- GERD
- Lung cancer
- Pneumonia
- Risk factors
EHF
Extended high frequency hearing and speech perception implications in adults and children.
EIF4E
Transcriptomic evidence that insulin signalling pathway regulates the ageing of subterranean termite castes.
ELF3
High Ambient Temperature Accelerates Leaf Senescence via PHYTOCHROME-INTERACTING FACTOR 4 and 5 in [i]Arabidopsis[/i].
ELOVL2
ELOVL2: Not just a biomarker of aging.
The lipid elongation enzyme ELOVL2 is a molecular regulator of aging in the retina.
MeSH Terms
- Aging
- Animals
- Cell Line
- DNA Methylation
- Decitabine
- Down-Regulation
- Fatty Acid Elongases
- Fatty Acids, Unsaturated
- Female
- Humans
- Macular Degeneration
- Male
- Mice
- Mice, Transgenic
- Point Mutation
- Promoter Regions, Genetic
- Retina
- Retinal Pigment Epithelium
Keywords
- DNA methylation
- ELOVL2
- PUFA
- age-related macular degeneration
- aging
- retina
EN1
Electrochemically detecting DNA methylation in the EN1 gene promoter: implications for understanding ageing and disease.
ENO1
Reduced expression of enolase-1 correlates with high intracellular glucose levels and increased senescence in cisplatin-resistant ovarian cancer cells.
ENTPD7
Inhibition of lung cancer cells and Ras/Raf/MEK/ERK signal transduction by ectonucleoside triphosphate phosphohydrolase-7 (ENTPD7).
MeSH Terms
- Adult
- Aged
- Animals
- Apoptosis
- Apyrase
- Biomarkers
- Cell Line, Tumor
- Cell Proliferation
- Cells, Cultured
- Female
- Gene Expression Regulation, Neoplastic
- Gene Silencing
- Humans
- Lung Neoplasms
- MAP Kinase Signaling System
- Male
- Mice
- Mice, Inbred BALB C
- Mice, Nude
- Middle Aged
- Mitogen-Activated Protein Kinases
- Plasmids
- Signal Transduction
- Survival Analysis
- raf Kinases
- ras Proteins
Keywords
- Ectonucleoside triphosphate phosphohydrolase-7
- Lung cancer
- Proliferation
- Senescence
EPO
Regulation of muscle and metabolic physiology by hypothalamic erythropoietin independently of its peripheral action.
Red Blood Cell Lifespan Shortening in Patients with Early-Stage Chronic Kidney Disease.
ERCC1
Chronic Sildenafil Treatment Improves Vasomotor Function in a Mouse Model of Accelerated Aging.
Local endothelial DNA repair deficiency causes aging-resembling endothelial-specific dysfunction.
MeSH Terms
- Age Factors
- Aging
- Animals
- Capillary Permeability
- Cellular Senescence
- Cyclin-Dependent Kinase Inhibitor p21
- DNA Damage
- DNA Repair
- DNA-Binding Proteins
- Endonucleases
- Endothelial Cells
- Endothelium, Vascular
- Mice, Inbred C57BL
- Mice, Knockout
- Nitric Oxide
- Nitric Oxide Synthase Type III
- Superoxides
- Vascular Stiffness
- Vasodilation
Keywords
- DNA damage
- aging
- endothelial dysfunction
- endothelium-dependent dilation
- nitric oxide
Tissue specificity of senescent cell accumulation during physiologic and accelerated aging of mice.
Deficiency in the DNA repair protein ERCC1 triggers a link between senescence and apoptosis in human fibroblasts and mouse skin.
ERF
Angiotensin-Converting Enzyme Gene D/I Polymorphism in Relation to Endothelial Function and Endothelial-Released Factors in Chinese Women.
Projections of Ambient Temperature- and Air Pollution-Related Mortality Burden Under Combined Climate Change and Population Aging Scenarios: a Review.
Exome Sequencing Analysis Identifies Rare Variants in [i]ATM[/i] and [i]RPL8[/i] That Are Associated With Shorter Telomere Length.
ERG
Effect of age and sex on neurodevelopment and neurodegeneration in the healthy eye: Longitudinal functional and structural study in the Long-Evans rat.
Mice With a Combined Deficiency of Superoxide Dismutase 1 (Sod1), DJ-1 (Park7), and Parkin (Prkn) Develop Spontaneous Retinal Degeneration With Aging.
MeSH Terms
- Aging
- Animals
- Biomarkers
- Electroretinography
- Enzyme-Linked Immunosorbent Assay
- Immunohistochemistry
- Malondialdehyde
- Mice
- Mice, Inbred C57BL
- Mice, Knockout
- Microscopy, Electron, Transmission
- Mitochondria
- Oxidative Stress
- Protein Deglycase DJ-1
- Retina
- Retinal Degeneration
- Retinal Pigment Epithelium
- Superoxide Dismutase-1
- Tomography, Optical Coherence
- Ubiquitin-Protein Ligases
ESPL1
Identification and genomic analysis of pedigrees with exceptional longevity identifies candidate rare variants.
ETS1
The transcription factor ETS1 promotes apoptosis resistance of senescent cholangiocytes by epigenetically up-regulating the apoptosis suppressor BCL2L1.
MeSH Terms
- ATP Binding Cassette Transporter, Subfamily B
- Animals
- Apoptosis
- Cellular Senescence
- Hepatocytes
- Humans
- Lipopolysaccharides
- Liver
- Mice
- Proto-Oncogene Protein c-ets-1
- Transcription Factors
- bcl-X Protein
Keywords
- BCL2 like 1 (BCL2L1)
- apoptosis
- cholangiocyte
- chromatin modification
- epigenetics
- gene expression
- primary sclerosing cholangitis (PSC)
- senescence
- transcription factor
EVL
Health Years in Total: A New Health Objective Function for Cost-Effectiveness Analysis.
EZH2
Linking gene expression and phenotypic changes in the developmental and evolutionary origins of osteosclerosis in the ribs of bowhead whales (Balaena mysticetus).
EZH2 is involved in vulnerability to neuroinflammation and depression-like behaviors induced by chronic stress in different aged mice.
A positive feedback loop between EZH2 and NOX4 regulates nucleus pulposus cell senescence in age-related intervertebral disc degeneration.
Perinatal exposure to bisphenol A impacts in the mammary gland morphology of adult Mongolian gerbils.
MeSH Terms
- Actins
- Aging
- Animals
- Benzhydryl Compounds
- Cell Proliferation
- Collagen
- Enhancer of Zeste Homolog 2 Protein
- Female
- Gerbillinae
- Histones
- Mammary Glands, Animal
- Phenols
- Pregnancy
- Prenatal Exposure Delayed Effects
Keywords
- BPA
- EZH2
- Environment pollutant
- Estrogen
- Morphologic alterations
- Phospho-histone-h3
F2
Environmental risk assessment of glufosinate-resistant soybean by pollen-mediated gene flow under field conditions in the region of the genetic origin.
Gestational arsenite exposure augments hepatic tumors of C3H mice by promoting senescence in F1 and F2 offspring via different pathways.
Familial Longevity is Associated with an Attenuated Thyroidal Response to Recombinant Human Thyroid Stimulating Hormone.
Conclusions from a behavioral aging study on male and female F2 hybrid mice on age-related behavior, buoyancy in water-based tests, and an ethical method to assess lifespan.
In utero exposure to acetaminophen and ibuprofen leads to intergenerational accelerated reproductive aging in female mice.
MeSH Terms
- Acetaminophen
- Aging
- Animals
- Animals, Newborn
- Cell Proliferation
- Female
- Fertility
- Forkhead Box Protein O3
- Germ Cells
- Ibuprofen
- Luteolysis
- Mice
- Ovary
- Pregnancy
- Prenatal Exposure Delayed Effects
- Proto-Oncogene Proteins c-akt
- Reproduction
- Signal Transduction
Keywords
- Infertility
- Oogenesis
- Risk factors
F3
A Comprehensive Analysis of Age and Gender Effects in European Portuguese Oral Vowels.
Prenatal exposure to an environmentally relevant phthalate mixture accelerates biomarkers of reproductive aging in a multiple and transgenerational manner in female mice.
Combining Frontal Transcranial Direct Current Stimulation With Walking Rehabilitation to Enhance Mobility and Executive Function: A Pilot Clinical Trial.
Multigenerational exposure to TiO nanoparticles in soil stimulates stress resistance and longevity of survived C. elegans via activating insulin/IGF-like signaling.
Co-expression network analysis identified hub genes critical to triglyceride and free fatty acid metabolism as key regulators of age-related vascular dysfunction in mice.
MeSH Terms
- Aging
- Animals
- Fatty Acids, Nonesterified
- Gene Expression Profiling
- Gene Expression Regulation
- Gene Regulatory Networks
- Lipid Metabolism
- Mice
- Microarray Analysis
- Signal Transduction
- Triglycerides
- Vascular Diseases
Keywords
- aging
- co-expression network
- hub gene
- module
- mouse
- vascular dysfunction
F5
Methylation signatures in peripheral blood are associated with marked age acceleration and disease progression in patients with primary sclerosing cholangitis.
Keywords
- ALP, alkaline phosphatase
- ALT, alanine aminotransferase
- Aging
- BMI, body mass index
- DNAm, DNA methylation
- ELF, enhanced liver fibrosis
- FDR, false discovery rate
- GGT, gamma-glutamyltransferase
- IBD, inflammatory bowel disease
- IL, interleukin
- LOXL2, lysyl oxidase-like-2
- NASH, non-alcoholic steatohepatitis
- PSC, primary sclerosing cholangitis
- SMA, smooth muscle actin
- UDCA, ursodeoxycholic acid
- biomarker
- inflammatory bowel disease
- primary sclerosing cholangitis
- prognosis
- ursodeoxycholic acid
Fermentation of Blackberry with [i]L. plantarum[/i] JBMI F5 Enhance the Protection Effect on UVB-Mediated Photoaging in Human Foreskin Fibroblast and Hairless Mice through Regulation of MAPK/NF-κB Signaling.
MeSH Terms
- Animals
- Cell Line
- Cell Survival
- Female
- Fermentation
- Fibroblasts
- Foreskin
- Fruit
- Lactobacillus plantarum
- Male
- Mice
- Mice, Hairless
- Plant Extracts
- Rubus
- Skin Aging
- Ultraviolet Rays
Keywords
- Lactobacillus plantarum
- MMPs
- fermented blackberry
- photoaging
- skin aging
- type I procollagen
F7
The Pattern of Mu Rhythm Modulation During Emotional Destination Memory: Comparison Between Mild Cognitive Impairment Patients and Healthy Controls.
MeSH Terms
- Aged
- Aging
- Cognitive Dysfunction
- Electroencephalography
- Emotions
- Female
- Frontal Lobe
- Humans
- Male
- Memory
- Neurophysiological Monitoring
- Neuropsychological Tests
- Task Performance and Analysis
- Temporal Lobe
Keywords
- Emotional destination memory
- Mu suppression
- fronto-temporal
- mild cognitive impairment
- mirror neurons
FAAH
Endocannabinoid genetic variation enhances vulnerability to THC reward in adolescent female mice.
FABP3
FABP3-mediated membrane lipid saturation alters fluidity and induces ER stress in skeletal muscle with aging.
MeSH Terms
- Aging
- Animals
- Cell Line
- Endoplasmic Reticulum Stress
- Eukaryotic Initiation Factor-2
- Fatty Acid Binding Protein 3
- Female
- Gene Knockdown Techniques
- Lipidomics
- Membrane Fluidity
- Membrane Lipids
- Mice, Inbred C57BL
- Mice, Knockout
- Muscle, Skeletal
- Myoblasts
- Phospholipids
- Protein-Serine-Threonine Kinases
- Sarcopenia
- Up-Regulation
Autophagy receptor OPTN (optineurin) regulates mesenchymal stem cell fate and bone-fat balance during aging by clearing FABP3.
Myokines as biomarkers of frailty and cardiovascular disease risk in females.
FADS1
Aging and FADS1 polymorphisms decrease the biosynthetic capacity of long-chain PUFAs: A human trial using [U- C]linoleic acid.
MeSH Terms
- Adult
- Age Factors
- Aged
- Aging
- Alleles
- Arachidonic Acid
- Area Under Curve
- Fatty Acid Desaturases
- Fatty Acids, Unsaturated
- Female
- Healthy Volunteers
- Humans
- Linoleic Acid
- Male
- Polymorphism, Single Nucleotide
Keywords
- Aging
- Arachidonic acid
- Fatty acid conversion
- Linoleic acid
- Lipid metabolism
- Long-chain polyunsaturated fatty acid
FANCD2
TFG-maintaining stability of overlooked FANCD2 confers early DNA-damage response.
FAP
Rapamycin Extends Life Span in Apc Colon Cancer FAP Model.
Exercise enhances skeletal muscle regeneration by promoting senescence in fibro-adipogenic progenitors.
Control of Muscle Fibro-Adipogenic Progenitors by Myogenic Lineage is Altered in Aging and Duchenne Muscular Dystrophy.
MeSH Terms
- Adipogenesis
- Adolescent
- Adult
- Adult Stem Cells
- Aged
- Aging
- Cells, Cultured
- Child
- Child, Preschool
- Female
- Humans
- Infant
- Male
- Middle Aged
- Muscle Development
- Muscular Dystrophy, Duchenne
- Myoblasts
- Young Adult
Keywords Adipocytes; Myofibroblasts; Muscle progenitors; Myopathies
FAS
Five-year change in maximum tongue pressure and physical function in community-dwelling elderly adults.
Inhibition of USP7 activity selectively eliminates senescent cells in part via restoration of p53 activity.
FES
An outpatient Tai Chi program: Effects on veterans' functional outcomes.
Gait Function in Adults Aged 50 Years and Older With Spina Bifida.
A Single Question as a Screening Tool to Assess Fear of Falling in Young-Old Community-Dwelling Persons.
Fall-related efficacy is a useful and independent index to detect fall risk in Japanese community-dwelling older people: a 1-year longitudinal study.
MeSH Terms
- Accidental Falls
- Activities of Daily Living
- Aged
- Aging
- Female
- Geriatric Assessment
- Humans
- Independent Living
- Japan
- Longitudinal Studies
- Male
- Physical Functional Performance
- Postural Balance
- Risk Factors
- Walking Speed
Keywords
- Accidental falls
- Aged
- Fall-related efficacy
- Japanese
- Physical performance
Investigating Changes in Real-time Conscious Postural Processing by Older Adults during Different Stance Positions Using Electroencephalography Coherence.
FEV
Prediction of Lung Function in Adolescence Using Epigenetic Aging: A Machine Learning Approach.
Effect of Age on the Efficacy and Safety of Once-Daily Single-Inhaler Triple Therapy Fluticasone Furoate/Umeclidinium/Vilanterol in Patients With Chronic Obstructive Pulmonary Disease: A Post Hoc Analysis of the IMPACT Trial.
A comprehensive analysis of factors related to lung function in older adults: Cross-sectional findings from the Canadian Longitudinal Study on Aging.
Risk factors associated with the detection of pulmonary emphysema in older asymptomatic respiratory subjects.
Tiotropium Respimat Efficacy and Safety in Asthma: Relationship to Age.
Current Bronchodilator Responsiveness Criteria Underestimate Asthma in Older Adults.
Physical performances show conflicting associations in aged manual workers.
FEV as a Standalone Spirometric Predictor and the Attributable Fraction for Death in Older Persons.
An Individualized Prediction Model for Long-term Lung Function Trajectory and Risk of COPD in the General Population.
MeSH Terms
- Adult
- Age Factors
- Aging
- Alcohol Drinking
- Algorithms
- Alkaline Phosphatase
- Body Height
- Bronchodilator Agents
- Cigarette Smoking
- Cohort Studies
- Cough
- Dyspnea
- Electrocardiography
- Female
- Forced Expiratory Volume
- Hematocrit
- Humans
- Leukocyte Count
- Longitudinal Studies
- Lung
- Machine Learning
- Male
- Middle Aged
- Pulmonary Disease, Chronic Obstructive
- Risk Assessment
- Serum Albumin
- Serum Globulins
- Sex Factors
- Spirometry
- Triglycerides
- Vital Capacity
Keywords
- COPD
- FEV(1)
- FEV(1)/FVC
- airflow limitation
- lung function
- predictive modeling
Telomere length and lung function in a population-based cohort of children and mid-life adults.
MeSH Terms
- Aged
- Asthma
- Body Mass Index
- Child
- Cohort Studies
- Cross-Sectional Studies
- Exercise
- Female
- Forced Expiratory Volume
- Humans
- Lung
- Male
- Respiratory Function Tests
- Risk Factors
- Smoking
- Spirometry
- Telomere
- Vital Capacity
Keywords
- aging
- cell senescence
- life course
- national cohort
- spirometry
FGA
Goal Pursuit, Goal Adjustment, and Pain in Middle-Aged Adults Aging With Physical Disability.
Tenacious Goal Pursuit, Flexible Goal Adjustment, and Life Satisfaction Among Chinese Older Adult Couples.
FGF19
Bile acid receptor agonists in primary biliary cholangitis: Regulation of the cholangiocyte secretome and downstream T cell differentiation.
FGF2
The influence of fibroblast growth factor 2 on the senescence of human adipose-derived mesenchymal stem cells during long-term culture.
FGF21
Differential effects of sulfur amino acid-restricted and low-calorie diets on gut microbiome profile and bile acid composition in male C57BL6/J mice.
Relationship between physical activity and circulating fibroblast growth factor 21 in middle-aged and older adults.
Exercise and dietary intervention ameliorate high-fat diet-induced NAFLD and liver aging by inducing lipophagy.
Mitochondria, immunosenescence and inflammaging: a role for mitokines?
Age-at-onset-dependent effects of sulfur amino acid restriction on markers of growth and stress in male F344 rats.
Fibroblast growth factor 21 prolongs lifespan and improves stress tolerance in the silkworm, [i]Bombyx mori[/i].
Neurogenesis and prolongevity signaling in young germ-free mice transplanted with the gut microbiota of old mice.
MeSH Terms
- Animals
- Butyrates
- Fecal Microbiota Transplantation
- Fibroblast Growth Factors
- Gastrointestinal Microbiome
- Germ-Free Life
- Hippocampus
- Intestines
- Liver
- Longevity
- Male
- Metabolome
- Mice, Inbred C57BL
- Microtubule-Associated Proteins
- Neurogenesis
- Neurons
- Neuropeptides
- Phenotype
- Proton Magnetic Resonance Spectroscopy
Fibroblast Growth Factor 21 Mediates the Associations between Exercise, Aging, and Glucose Regulation.
Effects of Moderate Chronic Food Restriction on the Development of Postprandial Dyslipidemia with Ageing.
MeSH Terms
- Adiposity
- Aging
- Animals
- Basic Helix-Loop-Helix Leucine Zipper Transcription Factors
- Blood Glucose
- Diet, Fat-Restricted
- Dietary Fats
- Disease Models, Animal
- Dyslipidemias
- Glucagon
- Insulin
- Lipids
- Liver
- Metabolic Syndrome
- Postprandial Period
- Rats
- Rats, Wistar
- Triglycerides
Keywords
- ChREBP
- adipose tissue
- ageing
- oral lipid loading test
- postprandial hypertrigliceridemia
- postprandial thermogenesis
FGF23
Phosphate as a Pathogen of Arteriosclerosis and Aging.
Plasma Soluble αKlotho, Serum Fibroblast Growth Factor 23, and Mobility Disability in Community-Dwelling Older Adults.
Protective effect of Polygonatum sibiricum Polysaccharide on D-galactose-induced aging rats model.
FGF23 expression is stimulated in transgenic α-Klotho longevity mouse model.
MeSH Terms
- Aldosterone
- Animals
- Bone and Bones
- Cardiovascular Diseases
- Disease Models, Animal
- Female
- Fibroblast Growth Factors
- Gene Knockout Techniques
- Glucuronidase
- Kidney
- Longevity
- Male
- Mice
- Mice, Inbred C57BL
- Mice, Transgenic
- Osteoblasts
- Protein Isoforms
- Transcriptome
Keywords
- Bone Biology
- Cardiovascular disease
Fibroblast growth factor 23 and symmetric dimethylarginine concentrations in geriatric cats.
FGFR1
Alignment of Alzheimer's disease amyloid β-peptide and klotho.
Satellite cell-specific ablation of Cdon impairs integrin activation, FGF signalling, and muscle regeneration.
FGFR4
FGFR4 Inhibitor BLU9931 Attenuates Pancreatic Cancer Cell Proliferation and Invasion While Inducing Senescence: Evidence for Senolytic Therapy Potential in Pancreatic Cancer.
FGR
Aurora kinase mRNA expression is reduced with increasing gestational age and in severe early onset fetal growth restriction.
FH
Genetic Factors of Alzheimer's Disease Modulate How Diet is Associated with Long-Term Cognitive Trajectories: A UK Biobank Study.
Volumetric alterations in the hippocampal subfields of subjects at increased risk of dementia.
MeSH Terms
- Adult
- Aging
- Alzheimer Disease
- Apolipoproteins E
- Atrophy
- Dementia
- Diffusion Magnetic Resonance Imaging
- Educational Status
- Female
- Genotype
- Hippocampus
- Humans
- Male
- Middle Aged
- Organ Size
- Risk
Keywords
- Alzheimer's disease
- Dementia
- Hippocampal subfields
- Hippocampus
- Preclinical dementia
Macroscopic hematuria as a risk factor for hypertension in ageing people with hemophilia and a family history of hypertension.
LDL Receptor Deficiency Does not Alter Brain Amyloid-β Levels but Causes an Exacerbation of Apoptosis.
MeSH Terms
- Aging
- Amyloid beta-Protein Precursor
- Animals
- Apoptosis
- Brain Chemistry
- Caspase 3
- Cholesterol
- Gene Expression
- Hippocampus
- Male
- Maze Learning
- Mice
- Mice, Inbred C57BL
- Mice, Knockout
- Prefrontal Cortex
- Receptors, LDL
Keywords
- Familial hypercholesterolemia
- LDLr-/- mice
- amyloid-β
- apoptosis
- memory impairment
FNDC5
Irisin Correlates Positively With BMD in a Cohort of Older Adult Patients and Downregulates the Senescent Marker p21 in Osteoblasts.
[Investigation of signal molecules in saliva: prospects of application for diagnostics of myocardial infarction and the aging rate of different age people.]
MeSH Terms
- Aged
- Aging
- Biomarkers
- Cytokines
- Humans
- Middle Aged
- Myocardial Infarction
- Saliva
- Tumor Necrosis Factor-alpha
Keywords
- aging
- diagnosis
- myocardial infarction
- saliva
- signaling molecules
FOS
Muscle atrophy-related myotube-derived exosomal microRNA in neuronal dysfunction: Targeting both coding and long noncoding RNAs.
FOSL2
LncRNA GUARDIN suppresses cellular senescence through a LRP130-PGC1α-FOXO4-p21-dependent signaling axis.
FOXA1
Analyses of an epigenetic switch involved in the activation of pioneer factor FOXA1 leading to the prognostic value of estrogen receptor and FOXA1 co-expression in breast cancer.
MeSH Terms
- Breast Neoplasms
- Down-Regulation
- Epigenesis, Genetic
- Female
- Gene Expression Regulation, Neoplastic
- Hepatocyte Nuclear Factor 3-alpha
- Humans
- Middle Aged
- Prognosis
- RNA, Messenger
- Receptor, ErbB-2
- Receptors, Estrogen
- Receptors, Progesterone
- Transcriptome
- Up-Regulation
Keywords
- FOXA1
- age-related diseases
- aging
- breast cancer
- hormone receptor
- methylation
- prognosis
FOXM1
Sirtuin 6 deficiency induces endothelial cell senescence via downregulation of forkhead box M1 expression.
FOXN1
Thymic rejuvenation via FOXN1-reprogrammed embryonic fibroblasts (FREFs) to counteract age-related inflammation.
FOXO1
l-Theanine attenuates liver aging by inhibiting advanced glycation end products in d-galactose-induced rats and reversing an imbalance of oxidative stress and inflammation.
FOXO3
The DNA methylation of FOXO3 and TP53 as a blood biomarker of late-onset asthma.
FOXO3 targets are reprogrammed as Huntington's disease neural cells and striatal neurons face senescence with p16 increase.
Astaxanthin as a Putative Geroprotector: Molecular Basis and Focus on Brain Aging.
Inflamma-miR-21 Negatively Regulates Myogenesis during Ageing.
Variable DNA methylation of aging-related genes is associated with male COPD.
MeSH Terms
- Adolescent
- Adult
- Age Factors
- Aged
- Aged, 80 and over
- Aging
- Case-Control Studies
- CpG Islands
- DNA Methylation
- Databases, Genetic
- Female
- Forced Expiratory Volume
- Forkhead Transcription Factors
- Genetic Predisposition to Disease
- Humans
- Lung
- Male
- Middle Aged
- Pulmonary Disease, Chronic Obstructive
- Risk Assessment
- Risk Factors
- Severity of Illness Index
- Sex Factors
- Transcriptome
- Vital Capacity
- Young Adult
Keywords
- Aging
- Aging-related genes
- COPD
- DNA methylation
A conserved role of the insulin-like signaling pathway in diet-dependent uric acid pathologies in Drosophila melanogaster.
MeSH Terms
- Animals
- Animals, Genetically Modified
- Cohort Studies
- Disease Models, Animal
- Drosophila melanogaster
- Feeding Behavior
- Female
- Gene Knockdown Techniques
- Gout
- Humans
- Insulin
- Kidney Calculi
- Longevity
- Male
- Metabolic Networks and Pathways
- Middle Aged
- NADPH Oxidases
- Polymorphism, Single Nucleotide
- Purines
- Signal Transduction
- Urate Oxidase
- Uric Acid
FOXO4
FOXO4-DRI alleviates age-related testosterone secretion insufficiency by targeting senescent Leydig cells in aged mice.
FOXP1
GATA6 regulates aging of human mesenchymal stem/stromal cells.
FSHR
FSHR ablation induces depression-like behaviors.
Direct actions of gonadotropins beyond the reproductive system and their role in human aging and neoplasia [Bezpośrednie działanie gonadotropin poza układem rozrodczym i ich rola w starzeniu się i nowotworzeniu u człowieka].
FTO
Decreased expression of m A demethylase FTO in ovarian aging.
FYN
An inhibitor role of Nrf2 in the regulation of myocardial senescence and dysfunction after myocardial infarction.
MeSH Terms
- Animals
- Cardiomyopathies
- Cellular Senescence
- Echocardiography
- Gene Silencing
- Male
- Mice
- Mice, Inbred C57BL
- Mice, Knockout
- Myocardial Infarction
- Myocardium
- Myocytes, Cardiac
- NF-E2-Related Factor 2
- RNA, Small Interfering
- Ventricular Remodeling
Keywords
- Cellular senescence
- Myocardial infarction
- Nrf2
- Oxidative stress
G6PD
G6PD overexpression protects from oxidative stress and age-related hearing loss.
The Sickle Effect: The Silent Titan Affecting Glycated Hemoglobin Reliability.
DNA damage and synaptic and behavioural disorders in glucose-6-phosphate dehydrogenase-deficient mice.
MeSH Terms
- Animals
- Brain
- DNA Breaks, Double-Stranded
- DNA Breaks, Single-Stranded
- DNA Damage
- Disease Models, Animal
- Enzyme Activation
- Female
- Glucosephosphate Dehydrogenase
- Glucosephosphate Dehydrogenase Deficiency
- Male
- Mental Disorders
- Mice
- Oxidation-Reduction
- Purkinje Cells
Keywords
- 8-Oxo-2′-deoxyguanine (8-oxodG)
- Aging
- Behavioural disorders
- Comet
- DNA damage
- Electrophysiology
- Gamma-H2AX (γH2AX)
- Glucose-6-phosphate dehydrogenase (G6PD)
- Lifespan
- Neurodegeneration
- Reactive oxygen species (ROS)
GAA
Mitochondrial damage and senescence phenotype of cells derived from a novel frataxin G127V point mutation mouse model of Friedreich's ataxia.
Age-Related Changes in Serum Guanidinoacetic Acid in Women.
GABARAP
Age-dependent loss of adipose Rubicon promotes metabolic disorders via excess autophagy.
MeSH Terms
- Adipocytes
- Adipogenesis
- Adipose Tissue
- Adiposity
- Aging
- Animals
- Apoptosis Regulatory Proteins
- Autophagy
- Fatty Liver
- Gene Knockout Techniques
- Glucose
- HEK293 Cells
- Humans
- Intracellular Signaling Peptides and Proteins
- Lipid Metabolism
- Metabolic Diseases
- Mice
- Mice, Inbred C57BL
- Mice, Knockout
- Microtubule-Associated Proteins
- Nuclear Receptor Coactivator 1
- Nuclear Receptor Coactivator 2
- PPAR gamma
GAL
Overexpression of Pitx1 attenuates the senescence of chondrocytes from osteoarthritis degeneration cartilage-A self-controlled model for studying the etiology and treatment of osteoarthritis.
β-Caryophyllene Reduces DNA Oxidation and the Overexpression of Glial Fibrillary Acidic Protein in the Prefrontal Cortex and Hippocampus of d-Galactose-Induced Aged BALB/c Mice.
MeSH Terms
- Aging
- Animals
- Antioxidants
- DNA Damage
- Disease Models, Animal
- Galactose
- Glial Fibrillary Acidic Protein
- Hippocampus
- Male
- Mice
- Mice, Inbred BALB C
- Neuroprotection
- Oxidative Stress
- Polycyclic Sesquiterpenes
- Prefrontal Cortex
Keywords
- CB2 receptor agonist
- biological aging
- cognitive flexibility
- phytocannabinoid
- β-caryophyllene
GAP43
HDAC inhibition leads to age-dependent opposite regenerative effect upon PTEN deletion in rubrospinal axons after SCI.
MeSH Terms
- Aging
- Animals
- Axons
- GAP-43 Protein
- Gene Deletion
- Gene Expression
- Histone Deacetylase Inhibitors
- Histone Deacetylases
- Hydroxamic Acids
- Mice, Transgenic
- Motor Activity
- Nerve Regeneration
- PTEN Phosphohydrolase
- Recovery of Function
- Spinal Cord
- Spinal Cord Injuries
Keywords
- Aging
- Epigenetics
- Histone deacetylase
- Pten
- Regeneration
- Spinal cord injury
GATA4
Epigenetics and Vascular Senescence-Potential New Therapeutic Targets?
Prolonged treatment with Y-27632 promotes the senescence of primary human dermal fibroblasts by increasing the expression of IGFBP-5 and transforming them into a CAF-like phenotype.
GBA
Reduced sphingolipid hydrolase activities, substrate accumulation and ganglioside decline in Parkinson's disease.
GC
Body Size and Cuticular Hydrocarbons as Larval Age Indicators in the Forensic Blow Fly, Chrysomya albiceps (Diptera: Calliphoridae).
Composition of peony petal fatty acids and flavonoids and their effect on Caenorhabditis elegans lifespan.
Photo aging and fragmentation of polypropylene food packaging materials in artificial seawater.
Secretory galectin-3 induced by glucocorticoid stress triggers stemness exhaustion of hepatic progenitor cells.
Optimization of Ethanol Detection by Automatic Headspace Method for Cellulose Insulation Aging of Oil-immersed Transformers.
Sensory, olfactometric and chemical characterization of the aroma potential of Garnacha and Tempranillo winemaking grapes.
MeSH Terms
- Fruit
- Gas Chromatography-Mass Spectrometry
- Hexanols
- Norisoprenoids
- Odorants
- Olfactometry
- Principal Component Analysis
- Sulfhydryl Compounds
- Vitis
- Volatile Organic Compounds
Keywords
- Aging
- Aroma precursors
- Glycosides
- Lipid-derived aroma
- Norisoprenoids
- Sensory properties
- Terpenols
- Volatile phenols
Accelerated Cognitive Ageing in epilepsy: exploring the effective connectivity between resting-state networks and its relation to cognitive decline.
Characterization of Jinhua ham aroma profiles in specific to aging time by gas chromatography-ion mobility spectrometry (GC-IMS).
Quantitative Profiling of Lipid Species in Caenorhabditis elegans with Gas Chromatography-Mass Spectrometry.
Physicochemical characterization of a polysaccharide from Agrocybe aegirita and its anti-ageing activity.
MeSH Terms
- Aging
- Agrocybe
- Antioxidants
- Carbohydrate Sequence
- Cell Line
- Chemical Phenomena
- G1 Phase Cell Cycle Checkpoints
- Humans
- Membrane Potential, Mitochondrial
- Mitochondria
- Polysaccharides
Keywords
- Agrocybe aegirita polysaccharide
- Anti-ageing
- Cell cycle
- Mitochondrial membrane potential
- Structure
Structural characteristics, antioxidant properties and antiaging activities of galactan produced by Mentha haplocalyx Briq.
Contribution of Volatile Odorous Terpenoid Compounds to Aged Cognac Spirits Aroma in a Context of Multicomponent Odor Mixtures.
Plasma Formate Is Greater in Fetal and Neonatal Rats Compared with Their Mothers.
Development of a new strategy for studying the aroma potential of winemaking grapes through the accelerated hydrolysis of phenolic and aromatic fractions (PAFs).
Compromised steady-state germinal center activity with age in nonhuman primates.
Endogenous Glucocorticoid Signaling in the Regulation of Bone and Marrow Adiposity: Lessons from Metabolism and Cross Talk in Other Tissues.
MeSH Terms
- Adipose Tissue
- Adiposity
- Animals
- Bone Marrow
- Energy Metabolism
- Glucocorticoids
- Homeostasis
- Humans
- Liver
- Muscle, Skeletal
- Receptor Cross-Talk
- Receptors, Glucocorticoid
- Signal Transduction
- Stress, Physiological
Keywords
- Adipocyte
- Aging
- Bone marrow
- Corticosterone
- Cortisol
- Cortisone
- Glucocorticoid
- Osteoblast
4,5-Diphenyl-2-methyl picolinate induces cellular senescence by accumulating DNA damage and activating associated signaling pathways in gastric cancer.
MeSH Terms
- Animals
- Antineoplastic Agents
- Apoptosis
- Cell Cycle
- Cell Proliferation
- Cellular Senescence
- DNA Damage
- Humans
- Mice
- Mice, Inbred BALB C
- Mice, Nude
- Picolinic Acids
- Signal Transduction
- Stomach Neoplasms
- Tumor Cells, Cultured
- Xenograft Model Antitumor Assays
Keywords
- Cellular senescence
- DNA damage
- Gastric cancer
- N-heterocyclic compound
Relationship Between the Dose Administered, Target Tissue Dose, and Toxicity Level After Acute Oral Exposure to Bifenthrin and Tefluthrin in Young Adult Rats.
MeSH Terms
- Administration, Oral
- Aging
- Animals
- Body Temperature
- Cerebellum
- Cyclopropanes
- Dose-Response Relationship, Drug
- Hydrocarbons, Fluorinated
- Liver
- Male
- Pyrethrins
- Rats
- Rats, Wistar
- Tissue Distribution
- Toxicokinetics
Keywords
- acute effects
- bifenthrin
- body temperature
- disposition
- rat
- tefluthrin
Sugar Beet Pectin Supplementation Did Not Alter Profiles of Fecal Microbiota and Exhaled Breath in Healthy Young Adults and Healthy Elderly.
MeSH Terms
- Aged
- Beta vulgaris
- Breath Tests
- Dietary Supplements
- Double-Blind Method
- Exhalation
- Fatty Acids, Volatile
- Feces
- Female
- Gastrointestinal Microbiome
- Healthy Volunteers
- Humans
- Male
- Pectins
- Volatile Organic Compounds
- Young Adult
Keywords
- aging
- dietary fiber
- elderly
- exhaled air
- microbiota
- pectin
- young adults
Identification and analysis of new α- and β-hydroxy ketones related to the formation of 3-methyl-2,4-nonanedione in musts and red wines.
MeSH Terms
- Alkanes
- Diacetyl
- Ethanol
- Fruit and Vegetable Juices
- Gas Chromatography-Mass Spectrometry
- Humans
- Hydrogen-Ion Concentration
- Ketones
- Limit of Detection
- Solid Phase Microextraction
- Stereoisomerism
- Time Factors
- Wine
Keywords
- 3-methyl-2,4-nonanedione
- Aroma precursor
- Hydroxy ketones
- Oxidation
- Premature aging
- Wine
Neonatal T Follicular Helper Cells Are Lodged in a Pre-T Follicular Helper Stage Favoring Innate Over Adaptive Germinal Center Responses.
MeSH Terms
- Adaptive Immunity
- Adjuvants, Immunologic
- Aging
- Animals
- Animals, Newborn
- Germinal Center
- Immunity, Innate
- Interleukin-13
- Lymphopoiesis
- Mice, Inbred C57BL
- T-Lymphocytes, Helper-Inducer
- Th2 Cells
- Transcriptome
Keywords
- T follicular helper cells
- adjuvant
- neonates
- transcriptional profile analysis
- vaccines
Identification of Dialkylpyrazines Off-Flavors in Oak Wood.
Metabolomics Coupled with Transcriptomics Approach Deciphering Age Relevance in Sepsis.
GCA
Familial aggregation of longevity in giant cell arteritis and polymyalgia rheumatica.
Interaction between Alcohol Consumption and Apolipoprotein E (ApoE) Genotype with Cognition in Middle-Aged Men.
GCK
The Impact of Biomarker Screening and Cascade Genetic Testing on the Cost-Effectiveness of MODY Genetic Testing.
GCLC
Aerobic exercise training partially reverses the impairment of Nrf2 activation in older humans.
GCLM
Silencing Bach1 alters aging-related changes in the expression of Nrf2-regulated genes in primary human bronchial epithelial cells.
MeSH Terms
- Adult
- Aged
- Aging
- Basic-Leucine Zipper Transcription Factors
- Bronchi
- Epithelial Cells
- Gene Expression
- Gene Silencing
- Glutamate-Cysteine Ligase
- Heme Oxygenase-1
- Humans
- Isothiocyanates
- Middle Aged
- NAD(P)H Dehydrogenase (Quinone)
- NF-E2-Related Factor 2
- RNA, Messenger
- RNA, Small Interfering
- Signal Transduction
- Young Adult
Keywords
- Aging
- Bach1
- Glutamate cysteine ligase
- Heme oxygenase
- Nrf2
- Sulforaphane
GDF11
Growth differentiation factor-11 supplementation improves survival and promotes recovery after ischemic stroke in aged mice.
Anti-Aging Effects of GDF11 on Skin.
Targeted Approach to Distinguish and Determine Absolute Levels of GDF8 and GDF11 in Mouse Serum.
Growth differentiation factor 11 impairs titanium implant healing in the femur and leads to mandibular bone loss.
Systemic GDF11 stimulates the secretion of adiponectin and induces a calorie restriction-like phenotype in aged mice.
Circulating factors in young blood as potential therapeutic agents for age-related neurodegenerative and neurovascular diseases.
MeSH Terms
- Age Factors
- Aging
- Animals
- Blood
- Bone Morphogenetic Proteins
- Chemokine CCL11
- Enzyme Therapy
- Enzymes
- Growth Differentiation Factors
- Mice
- Neurodegenerative Diseases
- Parabiosis
- Vascular Diseases
Keywords
- C-C motif chemokine 11
- Circulating factor
- Growth differentiation factor 11
- Neurodegenerative diseases
- Neurovascular diseases
- Young blood
Effects of Exercise Training on Growth and Differentiation Factor 11 Expression in Aged Mice.
GDF15
Disease-specific plasma levels of mitokines FGF21, GDF15, and Humanin in type II diabetes and Alzheimer's disease in comparison with healthy aging.
Growth differentiation factor 15 protects against the aging-mediated systemic inflammatory response in humans and mice.
Analysis of Epigenetic Age Predictors in Pain-Related Conditions.
GDF15 Plasma Level Is Inversely Associated With Level of Physical Activity and Correlates With Markers of Inflammation and Muscle Weakness.
GDF15 is an epithelial-derived biomarker of idiopathic pulmonary fibrosis.
MeSH Terms
- Aged
- Alveolar Epithelial Cells
- Animals
- Bleomycin
- Bronchoalveolar Lavage Fluid
- Case-Control Studies
- Disease Models, Animal
- Female
- Gene Expression Profiling
- Growth Differentiation Factor 15
- Humans
- Idiopathic Pulmonary Fibrosis
- Lung
- Male
- Mice
- Middle Aged
- Respiratory Function Tests
- Severity of Illness Index
- Survival Analysis
- Telomere
- Transcriptome
Keywords
- MIC-1
- NAG-1
- SASP
- aging
Senescence-associated tissue microenvironment promotes colon cancer formation through the secretory factor GDF15.
GDF5
An embryonic CaVβ1 isoform promotes muscle mass maintenance via GDF5 signaling in adult mouse.
MeSH Terms
- Adult
- Aged
- Aged, 80 and over
- Aging
- Animals
- Atrophy
- Calcium Channels, L-Type
- Denervation
- Embryo, Mammalian
- Exons
- Female
- Gene Expression Regulation, Developmental
- Growth Differentiation Factor 5
- Humans
- Male
- Mice
- Muscles
- Neuromuscular Junction
- Organ Size
- Physical Conditioning, Animal
- Protein Isoforms
- RNA Splicing
- Signal Transduction
- Young Adult
GDNF
GFR-α1 Expression in Substantia Nigra Increases Bilaterally Following Unilateral Striatal GDNF in Aged Rats and Attenuates Nigral Tyrosine Hydroxylase Loss Following 6-OHDA Nigrostriatal Lesion.
MeSH Terms
- Aging
- Animals
- Dopamine
- Glial Cell Line-Derived Neurotrophic Factor
- Glial Cell Line-Derived Neurotrophic Factor Receptors
- Neurons
- Oxidopamine
- Phosphorylation
- Rats
- Substantia Nigra
- Tyrosine 3-Monooxygenase
Keywords
- 6-hydroxydopamine
- Parkinson’s disease
- Substantia nigra
- aging
- nigrostriatal
- tyrosine hydroxylase
GEM
The Impact of Geriatric Emergency Management Nurses on the Care of Frail Older Patients in the Emergency Department: a Systematic Review.
GFAP
Immunohistological Detection of Active Satellite Cellsin Rat Dorsal Root Ganglia after Parenteral Administration of Lipopolysaccharide and during Aging.
Transgenic Mice Expressing Human α-Synuclein in Noradrenergic Neurons Develop Locus Ceruleus Pathology and Nonmotor Features of Parkinson's Disease.
ApoE Genotype-Dependent Response to Antioxidant and Exercise Interventions on Brain Function.
Age-Dependent Heterogeneity of Murine Olfactory Bulb Astrocytes.
Neuroinflammation in Aged Brain: Impact of the Oral Administration of Ellagic Acid Microdispersion.
Long-term treatment with spermidine increases health span of middle-aged Sprague-Dawley male rats.
Meta-analysis of human prefrontal cortex reveals activation of GFAP and decline of synaptic transmission in the aging brain.
Astroglial biotin deprivation under endoplasmic reticulum stress uncouples BCAA-mTORC1 role in lipid synthesis to prolong autophagy inhibition in the aging brain.
Long-lived mice with reduced growth hormone signaling have a constitutive upregulation of hepatic chaperone-mediated autophagy.
Lipopolysaccharide exposure during late embryogenesis triggers and drives Alzheimer-like behavioral and neuropathological changes in CD-1 mice.
Increased levels of Aβ42 decrease the lifespan of ob/ob mice with dysregulation of microglia and astrocytes.
Selective brain neuronal and glial losses without changes in GFAP immunoreactivity: Young versus mature adult Wistar rats.
GGCT
Blockade of γ-Glutamylcyclotransferase Enhances Docetaxel Growth Inhibition of Prostate Cancer Cells.
MeSH Terms
- Antineoplastic Agents
- Apoptosis
- Cell Line, Tumor
- Cell Proliferation
- Cellular Senescence
- Docetaxel
- Enzyme Inhibitors
- Gene Expression
- Humans
- Immunohistochemistry
- Male
- Prostatic Neoplasms
- RNA, Small Interfering
- gamma-Glutamylcyclotransferase
Keywords
- docetaxel
- pro-GA
- prostate cancer cells
- senescence
- γ-glutamylcyclotransferase
GHR
Tissue-Specific GHR Knockout Mice: An Updated Review.
GHRH
Physiological and metabolic features of mice with CRISPR/Cas9-mediated loss-of-function in growth hormone-releasing hormone.
Transcriptomic and metabolomic profiling of long-lived growth hormone releasing hormone knock-out mice: evidence for altered mitochondrial function and amino acid metabolism.
GIP
Absence of GIP secretion alleviates age-related obesity and insulin resistance.
MeSH Terms
- Adiponectin
- Adipose Tissue
- Age Factors
- Animals
- Diet
- Diet, High-Fat
- Enteroendocrine Cells
- Gastric Inhibitory Polypeptide
- Gene Expression
- Glucose Tolerance Test
- Insulin
- Insulin Resistance
- Leptin
- Male
- Mice, Inbred C57BL
- Mice, Knockout
- Mice, Transgenic
- Obesity
Keywords
- GIP
- aging
- incretin
- obesity
GIT2
Multidimensional informatic deconvolution defines gender-specific roles of hypothalamic GIT2 in aging trajectories.
GJC2
Zebrafish brain RNA sequencing reveals that cell adhesion molecules are critical in brain aging.
GK
Progression of diabetic kidney disease in T2DN rats.
MeSH Terms
- Aging
- Albuminuria
- Animals
- Blood Glucose
- Diabetes Mellitus, Type 2
- Diabetic Nephropathies
- Disease Progression
- Hypertrophy
- Kidney Glomerulus
- Male
- Membrane Proteins
- Organ Size
- Polyuria
- Rats
- Rats, Wistar
- Renin-Angiotensin System
- Water-Electrolyte Imbalance
Keywords
- diabetic glomerular disease
- diabetic nephropathy
- podocyte pathology
- renin-angiotensin-aldosterone system
- scanning ion microscopy
- type 2 diabetic nephropathy
GNAQ
GNAQ expression initiated in multipotent neural crest cells drives aggressive melanoma of the central nervous system.
MeSH Terms
- Aging
- Animals
- Central Nervous System Neoplasms
- Disease Models, Animal
- Disease Progression
- Embryonic Development
- Female
- GTP-Binding Protein alpha Subunits, Gq-G11
- Male
- Melanocytes
- Melanoma
- Meningeal Neoplasms
- Mice, Transgenic
- Multipotent Stem Cells
- Mutation
- Neoplasm Invasiveness
- Neural Crest
- Nevus
- Skin Neoplasms
- Uveal Neoplasms
Keywords
- GNAQ
- Plp1
- blue nevus
- leptomeningeal melanocytoma
- uveal melanoma
GNE
Aberrant mitochondrial morphology and function associated with impaired mitophagy and DNM1L-MAPK/ERK signaling are found in aged mutant Parkinsonian LRRK2 mice.
GPC1
Decreased expression of GPC1 in human skin keratinocytes and epidermis during ageing.
MeSH Terms
- Adult
- Aged
- Aged, 80 and over
- Aging
- Cell Proliferation
- Cells, Cultured
- Epidermis
- Female
- Fibroblast Growth Factor 2
- Gene Expression Regulation
- Glypicans
- Humans
- Keratinocytes
- Middle Aged
- RNA, Messenger
- Signal Transduction
- Skin
- Young Adult
Keywords
- Ageing
- Epidermis
- Glypican 1
- Human skin
- Keratinocytes
GPI
Blood factors transfer beneficial effects of exercise on neurogenesis and cognition to the aged brain.
GPR6
Accelerated Epigenetic Aging and Methylation Disruptions Occur in Human Immunodeficiency Virus Infection Prior to Antiretroviral Therapy.
GPT
Brain Structural-Behavioral Correlates Underlying Grooved Pegboard Test Performance Across Lifespan.
GPX1
Glutathione peroxidase-1 overexpression reduces oxidative stress, and improves pathology and proteome remodeling in the kidneys of old mice.
GPX3
Long noncoding RNA glutathione peroxidase 3-antisense inhibits lens epithelial cell apoptosis by upregulating glutathione peroxidase 3 expression in age-related cataract.
GPX4
l-carnitine supplementation during in vitro culture regulates oxidative stress in embryos from bovine aged oocytes.
Dietary Selenium Supplementation Ameliorates Female Reproductive Efficiency in Aging Mice.
GREM1
GREM1 inhibits osteogenic differentiation, senescence and BMP transcription of adipose-derived stem cells.
GREM2
Increase of gremlin 2 with age in human adipose-derived stromal/stem cells and its inhibitory effect on adipogenesis.
Keywords
- Adipogenic differentiation
- Adipose-derived stromal/stem stem cells
- Aging
- DAPI, 4′,6-diamidino-2-phenylindole
- FGF, fibroblast growth factor
- GREM2
- GREM2 knockdown
- HE, hematoxylin eosin
- Individual differences
- PBS, phosphate buffered Solution
- PFA, paraformaldehyde
- TGF-β, transforming growth factor beta
GRID1
Gene discovery for high-density lipoprotein cholesterol level change over time in prospective family studies.
GRIK2
Senescence of Normal Human Fibroblasts Relates to the Expression of Ionotropic Glutamate Receptor GluR6/Grik2.
GRK2
G protein-coupled receptor kinase 2 modifies the ability of Caenorhabditis elegans to survive oxidative stress.
G protein coupled receptor kinases modulate Caenorhabditis elegans reactions to heat stresses.
Loss of dynamic regulation of G protein-coupled receptor kinase 2 by nitric oxide leads to cardiovascular dysfunction with aging.
GRM3
Profiling gene expression in the human dentate gyrus granule cell layer reveals insights into schizophrenia and its genetic risk.
MeSH Terms
- Adolescent
- Adult
- Aged
- Aged, 80 and over
- Aging
- Bipolar Disorder
- Dentate Gyrus
- Depressive Disorder, Major
- Female
- Gene Expression Profiling
- Genetic Predisposition to Disease
- Genome-Wide Association Study
- Humans
- Male
- Middle Aged
- Neurons
- Quantitative Trait Loci
- Schizophrenia
- Transcriptome
- Young Adult
GRN
Stressful development: Integrating endoderm development, stress, and longevity.
A Scoping Review of the Evidence About the Nurses Improving Care for Healthsystem Elders (NICHE) Program.
GSC
[i]mastermind[/i] regulates niche ageing independently of the [i]Notch[/i] pathway in the [i]Drosophila[/i] ovary.
MeSH Terms
- Aging
- Animals
- Cellular Senescence
- Drosophila Proteins
- Drosophila melanogaster
- Female
- Germ Cells
- Nuclear Proteins
- Ovary
- Receptors, Notch
- Signal Transduction
- Stem Cell Niche
- Transcriptome
Keywords
- DE-cadherin
- Drosophila oogenesis
- Hedgehog
- mastermind
- niche ageing
- reactive oxygen species
GSTM1
The effects of everyday-life exposure to polycyclic aromatic hydrocarbons on biological age indicators.
GSTM2
Small Extracellular Vesicles Have GST Activity and Ameliorate Senescence-Related Tissue Damage.
GUK1
Characterization of the impact of GMP/GDP synthesis inhibition on replicative lifespan extension in yeast.
GZMK
Comprehensive Profiling of an Aging Immune System Reveals Clonal GZMK CD8 T Cells as Conserved Hallmark of Inflammaging.
H2AX
Evaluation of GammaH2AX in Buccal Cells as a Molecular Biomarker of DNA Damage in Alzheimer's Disease in the AIBL Study of Ageing.
Cisplatin-induced peripheral neuropathy is associated to neuronal senescence-like response.
Guanine Deaminase Stimulates Ultraviolet-induced Keratinocyte Senescence in Seborrhoeic Keratosis via Guanine Metabolites.
Do BRCA1 and BRCA2 gene mutation carriers have a reduced ovarian reserve? Protocol for a prospective observational study.
MeSH Terms
- Adolescent
- Adult
- Aging
- BRCA1 Protein
- BRCA2 Protein
- Female
- Germ-Line Mutation
- Heterozygote
- Humans
- Immunohistochemistry
- Middle Aged
- Observational Studies as Topic
- Ovarian Follicle
- Ovarian Reserve
- Prospective Studies
- Research Design
- Young Adult
Keywords
- BRCA
- DNA repair
- fertility
- follicle
- germline mutation
- oocyte
Slower rates of accumulation of DNA damage in leukocytes correlate with longer lifespans across several species of birds and mammals.
Phosphoproteomic analysis reveals plant DNA damage signalling pathways with a functional role for histone H2AX phosphorylation in plant growth under genotoxic stress.
MeSH Terms
- ATP-Binding Cassette Transporters
- Aging
- Arabidopsis
- Arabidopsis Proteins
- Cells, Cultured
- DNA Damage
- DNA Repair
- Gene Expression Regulation, Plant
- Gene Ontology
- Germination
- Histones
- Mass Spectrometry
- Phosphorylation
- Proteome
- Seeds
- Serine
- Signal Transduction
- Stress, Physiological
- X-Rays
Keywords
- ATAXIA TELANGIECTASIA MUTATED (ATM)
- DNA damage response
- DNA repair
- phosphorylation
- seed
HBM
The effects of dietary fatty acids on bone, hematopoietic marrow and marrow adipose tissue in a murine model of senile osteoporosis.
HBP1
Suppression of p38/HBP1 pathway alleviates hyperosmotic stress-induced senescent progression of chondrocyte senescence.
HCN1
Protein expression changes of HCN1 and HCN2 in hippocampal subregions of gerbils during the normal aging process.
HDAC1
HDAC1 modulates OGG1-initiated oxidative DNA damage repair in the aging brain and Alzheimer's disease.
MeSH Terms
- Acetylation
- Aging
- Alzheimer Disease
- Animals
- Astrocytes
- Base Sequence
- Benzophenones
- Brain
- Cognition
- Cognition Disorders
- DNA Damage
- DNA Glycosylases
- Down-Regulation
- Gene Ontology
- Guanine
- Histone Deacetylase 1
- Memory
- Mice, Inbred C57BL
- Mice, Knockout
- Neurons
- Oxidative Stress
- Promoter Regions, Genetic
HDAC10
Middle-aged female rats lack changes in histone H3 acetylation in the anterior hypothalamus observed in young females on the day of a luteinizing hormone surge.
HDAC2
EEF1A1 deacetylation enables transcriptional activation of remyelination.
MeSH Terms
- Acetylation
- Aging
- Animals
- Cell Dedifferentiation
- Cell Nucleus
- Histone Deacetylase 1
- Histone Deacetylase 2
- Lysine Acetyltransferase 5
- Mice
- Models, Biological
- Oligodendroglia
- Peptide Elongation Factor 1
- Peripheral Nervous System
- Recovery of Function
- Remyelination
- SOXE Transcription Factors
- STAT3 Transcription Factor
- Schwann Cells
- Theophylline
- Trans-Activators
- Transcriptional Activation
HDAC3
Histone deacetylase-3: Friend and foe of the brain.
Loss of HDAC3 contributes to meiotic defects in aged oocytes.
HDAC4
The posttranslational modification of HDAC4 in cell biology: Mechanisms and potential targets.
HDAC6
Inhibition of HDAC6 Attenuates Diabetes-Induced Retinal Redox Imbalance and Microangiopathy.
HDC
Induced pluripotency and spontaneous reversal of cellular aging in supercentenarian donor cells.
MeSH Terms
- Adult
- Aged, 80 and over
- Cell Differentiation
- Cell Line
- Cellular Reprogramming
- Cellular Senescence
- Child
- Clone Cells
- Gene Expression Regulation
- Humans
- Induced Pluripotent Stem Cells
- Mesenchymal Stem Cells
- Telomere Homeostasis
- Tissue Donors
- Transcriptome
Keywords
- Aging
- Longevity
- Reprogramming
- Supercentenarian
- Telomere
- iPSC
HES1
A Single-Cell Transcriptomic Atlas of Human Skin Aging.
HFE
Polyphenol Characterization and Skin-Preserving Properties of Hydroalcoholic Flower Extract from [i]Himantoglossum robertianum[/i] (Orchidaceae).
HGD
High-glucose diets induce mitochondrial dysfunction in Caenorhabditis elegans.
HGF
Age-related changes in the immunomodulatory effects of human dental pulp derived mesenchymal stem cells on the CD4 T cell subsets.
Hepatocyte growth factor (HGF) and stem cell factor (SCF) maintained the stemness of human bone marrow mesenchymal stem cells (hBMSCs) during long-term expansion by preserving mitochondrial function via the PI3K/AKT, ERK1/2, and STAT3 signaling pathways.
Phenytoin sodium-ameliorated gingival fibroblast aging is associated with autophagy.
Impaired integrin α /β -mediated hepatocyte growth factor release by stellate cells of the aged liver.
HGS
Handgrip strength asymmetry is associated with future falls in older Americans.
Examining Additional Aspects of Muscle Function with a Digital Handgrip Dynamometer and Accelerometer in Older Adults: A Pilot Study.
The Relationship between Muscular Strength and Depression in Older Adults with Chronic Disease Comorbidity.
Handgrip Strength in the Korean Population: Normative Data and Cutoff Values.
Handgrip Strength Asymmetry and Weakness Are Associated with Lower Cognitive Function: A Panel Study.
Handgrip Strength Asymmetry and Weakness are Differentially Associated with Functional Limitations in Older Americans.
Absolute and Body Mass Index Normalized Handgrip Strength Percentiles by Gender, Ethnicity, and Hand Dominance in Americans.
Hand grip strength variability during serial testing as an entropic biomarker of aging: a Poincaré plot analysis.
Physical Activity and Fitness in White- and Blue-Collar Retired Men.
MeSH Terms
- Aged
- Aged, 80 and over
- Aging
- Body Mass Index
- Exercise
- Geriatric Assessment
- Humans
- Longitudinal Studies
- Male
- Men's Health
- Occupations
- Physical Fitness
- Poland
- Retirement
- Social Class
- Surveys and Questionnaires
- Task Performance and Analysis
Keywords
- Retirement
- occupation
- old men
- physical activity
Association between Hand Grip Strength and Self-Rated Health in Middle- and Old-Aged Korean Citizens.
Weakness May Have a Causal Association With Early Mortality in Older Americans: A Matched Cohort Analysis.
Associations Between Dietary Patterns and Handgrip Strength: The Korea National Health and Nutrition Examination Survey 2014-2016.
Effect of relative handgrip strength on cardiovascular disease among Korean adults aged 45 years and older: Results from the Korean Longitudinal Study of Aging (2006-2016).
Weakness and cognitive impairment are independently and jointly associated with functional decline in aging Americans.
Association of phase angle with sarcopenia and its components in physically active older women.
HLA-DRB1
The pathophysiology of polymyalgia rheumatica, small pieces of a big puzzle.
HMGA1
Characterization of [i]HMGA1P6[/i] transgenic mouse embryonic fibroblasts.
HMGA2
4D Genome Rewiring during Oncogene-Induced and Replicative Senescence.
MeSH Terms
- Cells, Cultured
- Cellular Senescence
- Chromatin Assembly and Disassembly
- DNA (Cytosine-5-)-Methyltransferase 1
- DNA Methylation
- Fibroblasts
- Genome, Human
- Heterochromatin
- Humans
- In Situ Hybridization, Fluorescence
- Oncogenes
Keywords
- 3D genome architecture
- DNMT1
- Hi-C
- chromatin compartments
- gene regulation
- oncogene-induced senescence
- replicative senescence
- senescence
The protective effects of HMGA2 in the senescence process of bone marrow-derived mesenchymal stromal cells.
HMGB1
Senescent human melanocytes drive skin ageing via paracrine telomere dysfunction.
MeSH Terms
- Adult
- Aged
- Aged, 80 and over
- Aging
- Atrophy
- Cells, Cultured
- Cellular Senescence
- Cyclin-Dependent Kinase Inhibitor p16
- Epidermis
- Female
- Humans
- Male
- Melanocytes
- Middle Aged
- Paracrine Communication
- Reactive Oxygen Species
- Receptors, CXCR4
- Skin
- Telomere
- Young Adult
Keywords
SASP
- melanocytes
- senescence
- skin ageing
- telomeres
HMGCR
Cholesterol Homeostasis: An In Silico Investigation into How Aging Disrupts Its Key Hepatic Regulatory Mechanisms.
Artesunate inhibits the mevalonate pathway and promotes glioma cell senescence.
HOXD8
Single-Cell Transcriptome Analysis Reveals Six Subpopulations Reflecting Distinct Cellular Fates in Senescent Mouse Embryonic Fibroblasts.
HP
A narrative review of highly processed food addiction across the lifespan.
Beta Human Papillomavirus 8E6 Attenuates LATS Phosphorylation after Failed Cytokinesis.
MeSH Terms
- Apoptosis
- Cell Cycle Proteins
- Cell Line, Tumor
- Cell Proliferation
- Cell Survival
- Cytochalasin B
- Cytokinesis
- DNA Repair
- E1A-Associated p300 Protein
- Gene Expression Regulation
- HCT116 Cells
- Host-Pathogen Interactions
- Humans
- Keratinocytes
- Oncogene Proteins, Viral
- Osteoblasts
- Papillomaviridae
- Phenotype
- Phosphorylation
- Primary Cell Culture
- Protein-Serine-Threonine Kinases
- Signal Transduction
- Transcription Factors
- Tumor Suppressor Protein p53
Keywords
- Hippo signaling pathway
- apoptosis
- cancer
- cytokinesis
- human papillomavirus
- senescence
- skin cancer
HPSE
Distribution of heparan sulfate correlated with the expression of heparanase-1 and matrix metalloproteinase-9 in an ovariectomized rats skin.
HR
Patients with hip fracture and total hip arthroplasty surgery differ in anthropometric, but not cardiovascular screening abnormalities.
Clinical Role of Lung Ultrasound for the Diagnosis and Prognosis of Coronavirus Disease Pneumonia in Elderly Patients: A Pivotal Study.
The Relationship of Accelerometer-Assessed Standing Time With and Without Ambulation and Mortality: The WHI OPACH Study.
Age-related myofiber atrophy in old mice is reversed by ten weeks voluntary high-resistance wheel running.
Predicted Skeletal Muscle Mass and 4-Year Cardiovascular Disease Incidence in Middle-Aged and Elderly Participants of IKARIA Prospective Epidemiological Study: The Mediating Effect of Sex and Cardiometabolic Factors.
Obesity is associated with early hip fracture risk in postmenopausal women: a 25-year follow-up.
ATM inhibition synergizes with fenofibrate in high grade serous ovarian cancer cells.
Effectiveness of adjuvant FOLFOX vs 5FU/LV in adults over age 65 with stage II and III colon cancer using a novel hybrid approach.
Age, Frailty, and Comorbidity as Prognostic Factors for Short-Term Outcomes in Patients With Coronavirus Disease 2019 in Geriatric Care.
MeSH Terms
- Age Factors
- Aged
- Aged, 80 and over
- Betacoronavirus
- COVID-19
- Comorbidity
- Coronavirus Infections
- Female
- Frail Elderly
- Geriatrics
- Humans
- Male
- Models, Statistical
- Outcome Assessment, Health Care
- Pandemics
- Pneumonia, Viral
- Prognosis
- SARS-CoV-2
- Survival Analysis
- Sweden
Keywords
- COVID-19
- aging
- comorbidity
- frailty
- geriatrics
- survival
Clinical and demographic parameters predict the progression from mild cognitive impairment to dementia in elderly patients.
Plasma Dehydroepiandrosterone Sulfate and Cardiovascular Disease Risk in Older Men and Women.
High intensity interval training combined with L-citrulline supplementation: Effects on physical performance in healthy older adults.
Associations of blood pressure with risk of injurious falls in old age vary by functional status: A cohort study.
Epigenetic age acceleration and clinical outcomes in gliomas.
Do Stairs Inhibit Seniors Who Live on Upper Floors From Going Out?
Age-specific acute changes in carotid-femoral pulse wave velocity with head-up tilt.
Pre-frailty status increases the risk of rehospitalization in patients after elective cardiac surgery without complication.
Comparative Performance of Creatinine-Based GFR Estimation Equations in Exceptional Longevity: The Rugao Longevity and Ageing Study.
MeSH Terms
- Aged, 80 and over
- Creatinine
- Female
- Glomerular Filtration Rate
- Humans
- Kidney Function Tests
- Longevity
- Male
- Mortality
- Predictive Value of Tests
- Renal Insufficiency
- Reproducibility of Results
- Risk Factors
Keywords
- equation
- exceptional longevity
- glomerular filtration rate
- kidney function
- mortality
Sex-and race-specific associations of protein intake with change in muscle mass and physical function in older adults: the Health, Aging, and Body Composition (Health ABC) Study.
MeSH Terms
- Aged
- Aged, 80 and over
- Aging
- Biomass
- Body Composition
- Body Weight
- Dietary Proteins
- Female
- Humans
- Independent Living
- Male
- Muscle Development
- Muscle Strength
- Muscles
- Prospective Studies
- Sex Factors
Keywords
- appendicular lean body mass
- community-dwelling
- gait speed
- mobility limitation
- old age
- optimal intake
- physical performance
- spline functions
Deterioration of bone microstructure by aging and menopause in Japanese healthy women: analysis by HR-pQCT.
MeSH Terms
- Absorptiometry, Photon
- Adult
- Aged
- Aging
- Asian Continental Ancestry Group
- Bone Density
- Bone and Bones
- Cancellous Bone
- Cortical Bone
- Female
- Finite Element Analysis
- Humans
- Japan
- Linear Models
- Menopause
- Middle Aged
- Porosity
- Tomography, X-Ray Computed
Keywords
- Bone microstructure
- Estimated bone strength
- High resolution peripheral quantitative CT (HR-pQCT)
- Japanese women
- Non-metric trabecular parameter
Association between Low Protein Intake and Mortality in Patients with Type 2 Diabetes.
CAUSES, mortality rates and risk factors of death in community-dwelling Europeans aged 50 years and over: Results from the Survey of Health, Ageing and Retirement in Europe 2013-2015.
MeSH Terms
- Activities of Daily Living
- Aged
- Aging
- Cohort Studies
- Europe
- Humans
- Independent Living
- Male
- Middle Aged
- Mortality
- Proportional Hazards Models
- Prospective Studies
- Retirement
- Risk Factors
- Surveys and Questionnaires
Keywords
- Aging
- Comorbidity
- Depressive symptoms
- Diseases
- Mortality risk
Estimation of Wave Condition Number From Pressure Waveform Alone and Its Changes With Advancing Age in Healthy Women and Men.
Extended in vitro culture of primary human mesenchymal stem cells downregulates Brca1-related genes and impairs DNA double-strand break recognition.
Effect of artificial dawn light on cardiovascular function, alertness, and balance in middle-aged and older adults.
Heart Rate Performance Curve Is Dependent on Age, Sex, and Performance.
Physical activity trajectories, mortality, hospitalization, and disability in the Toledo Study of Healthy Aging.
U-Shaped Association of Plasma Testosterone, and no Association of Plasma Estradiol, with Incidence of Fractures in Men.
Pregnancy-Related Bone Mineral and Microarchitecture Changes in Women Aged 30 to 45 Years.
Analysis of the world record time for combined father and son marathon.
Age-related reductions in heart rate variability do not worsen during exposure to humid compared to dry heat: A secondary analysis.
Efficacy and Safety of Dapagliflozin in the Elderly: Analysis From the DECLARE-TIMI 58 Study.
MeSH Terms
- Adult
- Age Factors
- Aged
- Aged, 80 and over
- Aging
- Benzhydryl Compounds
- Cardiovascular System
- Diabetes Mellitus, Type 2
- Diabetic Ketoacidosis
- Female
- Glucosides
- Humans
- Hypoglycemia
- Hypoglycemic Agents
- Incidence
- Kidney
- Male
- Middle Aged
- Sodium-Glucose Transporter 2 Inhibitors
- Survival Analysis
- Treatment Outcome
- Urinary Tract Infections
Validity of Prediction Equations of Maximal Heart Rate in Physically Active Female Adolescents and the Role of Maturation.
Base excision repair but not DNA double-strand break repair is impaired in aged human adipose-derived stem cells.
MeSH Terms
- Adipose Tissue
- Adult
- Aging
- DNA Breaks, Double-Stranded
- DNA End-Joining Repair
- DNA Repair
- Humans
- Middle Aged
- Recombinational DNA Repair
- Stem Cells
- Up-Regulation
- X-ray Repair Cross Complementing Protein 1
- Young Adult
Keywords
- XRCC1
- adipose-derived stem cells
- base excision repair
- genome integrity
- human aging
Urban-Rural Differences in Hip Fracture Mortality: A Nationwide NOREPOS Study.
Malnutrition as a Strong Predictor of the Onset of Sarcopenia.
Acclimation to a thermoneutral environment abolishes age-associated alterations in heart rate and heart rate variability in conscious, unrestrained mice.
Long-term dementia risk prediction by the LIBRA score: A 30-year follow-up of the CAIDE study.
MeSH Terms
- Aged
- Apolipoproteins E
- Cognitive Dysfunction
- Dementia
- Female
- Follow-Up Studies
- Genetic Predisposition to Disease
- Humans
- Life Style
- Male
- Protective Factors
- Risk Assessment
- Risk Factors
Keywords
- cognitive aging
- cohort study
- dementia
- epidemiology
- lifestyle
- prevention
- risk factors
Kidney function and its association to imminent, short- and long-term fracture risk-a longitudinal study in older women.
Oxidatively Damaged DNA/RNA and 8-Isoprostane Levels Are Associated With the Development of Type 2 Diabetes at Older Age: Results From a Large Cohort Study.
Associations of vigorous physical activity with all-cause, cardiovascular and cancer mortality among 64 913 adults.
Reduced cerebrovascular and cardioventilatory responses to intermittent hypoxia in elderly.
MeSH Terms
- Adult
- Aged
- Aging
- Blood Pressure
- Brain
- Cerebrovascular Circulation
- Female
- Heart Rate
- Humans
- Hypoxia
- Male
- Pulmonary Ventilation
- Ultrasonography, Doppler, Transcranial
- Young Adult
Keywords
- Aging
- Arterial oxygen saturation
- Cerebral blood flow
- Cerebral tissue oxygenation
- Heart rate
- Hypoxemia
- Ventilation
Vestibulo-sympathetic reflex in patients with bilateral vestibular loss.
Heart rate and blood pressure in male Ts65Dn mice: a model to investigate cardiovascular responses in Down syndrome.
Body weight at 10 years of age and change in body composition between 8 and 10 years of age were related to survival in a longitudinal study of 39 Labrador retriever dogs.
Dietary diversity offsets the adverse mortality risk among older indigenous Taiwanese.
Independent and joint effects of vascular and cardiometabolic risk factor pairs for risk of all-cause dementia: a prospective population-based study.
MeSH Terms
- Aged
- Aged, 80 and over
- Aging
- Apolipoprotein E4
- Cognitive Dysfunction
- Dementia
- Exercise
- Female
- Heart Failure
- Heterozygote
- Humans
- Hypertension
- Male
- Pennsylvania
- Proportional Hazards Models
- Prospective Studies
- Risk Factors
- Stroke
Keywords
- Alzheimer‘s disease (AD)
- apolipoprotein E (APOE)
- cerebral vascular disease (CVD)
- dementia
- epidemiology
Work Ability and Job Survival: Four-Year Follow-Up.
Predictivity of bioimpedance phase angle for incident disability in older adults.
HRAS
How do combinations of unhealthy behaviors relate to attitudinal factors and subjective health among the adult population in the Netherlands?
MeSH Terms
- Adult
- Alcohol Drinking
- Attitude to Health
- Cluster Analysis
- Diagnostic Self Evaluation
- Diet, Healthy
- Exercise
- Female
- Health Risk Behaviors
- Humans
- Life Expectancy
- Life Style
- Logistic Models
- Male
- Middle Aged
- Netherlands
- Prevalence
- Sedentary Behavior
- Smoking
- Surveys and Questionnaires
- Young Adult
Keywords
- Clustering risk attitude
- Health behaviours
- Subjective health
- Time orientation
Elucidating Proteoform Dynamics Underlying the Senescence Associated Secretory Phenotype.
HS2ST1
Whole Genome Analysis of the Red-Crowned Crane Provides Insight into Avian Longevity.
HSF1
A Mitochondrial Stress-Specific Form of HSF1 Protects against Age-Related Proteostasis Collapse.
Heat shock factor 1-mediated transcription activation of Omi/HtrA2 induces myocardial mitochondrial apoptosis in the aging heart.
MeSH Terms
- Aging
- Animals
- Apoptosis
- Heat Shock Transcription Factors
- High-Temperature Requirement A Serine Peptidase 2
- Male
- Mice
- Mice, Inbred C57BL
- Mitochondria, Heart
- Myocytes, Cardiac
- NIH 3T3 Cells
- Transcriptional Activation
- Up-Regulation
Keywords
- Omi/HtrA2
- age-related pathology
- cardiovascular
- mitochondria
- transcriptional regulation
Multifactorial Attenuation of the Murine Heat Shock Response With Age.
HSPA1A
Vitamin D3 treatment regulates apoptosis, antioxidant defense system, and DNA integrity in the epididymal sperm of an aged rat model.
HSPA1L
Melatonin suppresses senescence-derived mitochondrial dysfunction in mesenchymal stem cells via the HSPA1L-mitophagy pathway.
HTT
Biological Aging and the Cellular Pathogenesis of Huntington's Disease.
ICE1
ATBS1-INTERACTING FACTOR 2 negatively regulates dark- and brassinosteroid-induced leaf senescence through interactions with INDUCER OF CBF EXPRESSION 1.
IDE
Dendrobium nobile Lindl. Alkaloids Ameliorate Cognitive Dysfunction in Senescence Accelerated SAMP8 Mice by Decreasing Amyloid-β Aggregation and Enhancing Autophagy Activity.
IDH2
Reactive oxygen species-mediated senescence is accelerated by inhibiting Cdk2 in Idh2-deficient conditions.
MeSH Terms
- Animals
- Cellular Senescence
- Cyclin-Dependent Kinase 2
- Cyclin-Dependent Kinase Inhibitor p21
- Embryo, Mammalian
- Fibroblasts
- Isocitrate Dehydrogenase
- Mice
- Mice, Knockout
- NIH 3T3 Cells
- Reactive Oxygen Species
Keywords
- cell cycle
- cyclin-dependent kinase 2 (Cdk2)
- isocitrate dehydrogenase 2 (IDH2)
- reactive oxygen species (ROS)
- senescence
IDS
Effect of immediate dentine sealing on the aging and fracture strength of lithium disilicate inlays and overlays.
IFI27
Ultraviolet B irradiation-induced keratinocyte senescence and impaired development of 3D epidermal reconstruct.
IGF1
Genetic differences and longevity-related phenotypes influence lifespan and lifespan variation in a sex-specific manner in mice.
17α-estradiol modulates IGF1 and hepatic gene expression in a sex-specific manner.
Pan-mammalian analysis of molecular constraints underlying extended lifespan.
17α-Estradiol promotes ovarian aging in growth hormone receptor knockout mice, but not wild-type littermates.
IGF1R
Comparison of mitochondrial transplantation by using a stamp-type multineedle injector and platelet-rich plasma therapy for hair aging in naturally aging mice.
IGFBP1
Role of IGFBP1 in the senescence of vascular endothelial cells and severity of aging‑related coronary atherosclerosis.
MeSH Terms
- Adult
- Aged
- Aged, 80 and over
- Aging
- Atherosclerosis
- Cells, Cultured
- Cellular Senescence
- Coronary Artery Disease
- Coronary Vessels
- Down-Regulation
- Endothelial Cells
- Female
- Humans
- Insulin-Like Growth Factor Binding Protein 1
- Jagged-1 Protein
- Male
- Middle Aged
- Signal Transduction
- Up-Regulation
IGFBP2
Intracellular Insulin-like growth factor binding protein 2 (IGFBP2) contributes to the senescence of keratinocytes in psoriasis by stabilizing cytoplasmic p21.
IGFBP3
Cellular and Molecular Biomarkers Indicate Premature Aging in Pseudoxanthoma Elasticum Patients.
Paracrine senescence of human endometrial mesenchymal stem cells: a role for the insulin-like growth factor binding protein 3.
IGFBP4
Quantitative iTRAQ-based proteomic analysis of differentially expressed proteins in aging in human and monkey.
IGFBP7
Reprogramming of human fibroblasts into osteoblasts by insulin-like growth factor-binding protein 7.
IHH
Indian Hedgehog regulates senescence in bone marrow-derived mesenchymal stem cell through modulation of ROS/mTOR/4EBP1, p70S6K1/2 pathway.
IL10
The beneficial effect of physical exercise on inflammatory makers in older individuals.
Astrocyte senescence may drive alterations in GFAPα, CDKN2A p14 , and TAU3 transcript expression and contribute to cognitive decline.
MeSH Terms
- Aged
- Alternative Splicing
- Astrocytes
- Cells, Cultured
- Cellular Senescence
- Cognitive Dysfunction
- Cytokines
- Gene Expression
- Glial Fibrillary Acidic Protein
- Humans
- Matrix Metalloproteinases
- Transcription, Genetic
- Tumor Suppressor Protein p14ARF
- tau Proteins
Keywords
- Alternative splicing
- Gene expression
- Neurodegenerative disease
- Senescence
Dietary Spray-Dried Porcine Plasma Prevents Cognitive Decline in Senescent Mice and Reduces Neuroinflammation and Oxidative Stress.
IL15
Moderate physical activity associated with a higher naïve/memory T-cell ratio in healthy old individuals: potential role of IL15.
IL1A
IL1B triggers inflammatory cytokine production in bovine oviduct epithelial cells and induces neutrophil accumulation via CCL2.
IL2
Impact of Aging on the Phenotype of Invariant Natural Killer T Cells in Mouse Thymus.
IL6
Basic immunology may lead to translational therapeutic rationale: SARS-CoV-2 and rheumatic diseases.
MeSH Terms
- Adaptive Immunity
- Aged
- Antirheumatic Agents
- COVID-19
- Comorbidity
- Coronavirus Infections
- Disease Outbreaks
- Female
- Humans
- Hydroxychloroquine
- Immunity, Innate
- Immunologic Factors
- Immunosuppressive Agents
- Italy
- Male
- Middle Aged
- Pandemics
- Pneumonia, Viral
- Rheumatic Diseases
- Risk Assessment
- Severe Acute Respiratory Syndrome
Keywords
- COVID-19
- SARS-CoV-2
- geriatrics
- pathophysiology
- pediatrics
- rheumatology
ATM-deficient neural precursors develop senescence phenotype with disturbances in autophagy.
The microRNA-34a-Induced Senescence-Associated Secretory Phenotype (SASP) Favors Vascular Smooth Muscle Cells Calcification.
Impact of Influenza on Pneumococcal Vaccine Effectiveness during [i]Streptococcus pneumoniae[/i] Infection in Aged Murine Lung.
Patterns of multi-domain cognitive aging in participants of the Long Life Family Study.
Cholest-4,6-Dien-3-One Promote Epithelial-To-Mesenchymal Transition (EMT) in Biliary Tree Stem/Progenitor Cell Cultures In Vitro.
MeSH Terms
- Biliary Tract
- Cell Differentiation
- Cell Proliferation
- Cells, Cultured
- Cellular Senescence
- Cholestenones
- Epithelial-Mesenchymal Transition
- Histone Deacetylase 6
- Humans
- Interleukin-6
- Signal Transduction
- Stem Cells
- Tissue Donors
Keywords
- BMP pathway
- SHH pathway
- biliary tree stem/progenitor cells (BTSCs)
- epithelial-to-mesenchymal transition (EMT)
- primary sclerosing cholangitis (PSC)
- senescence
- telomerase
Single xenotransplant of rat brown adipose tissue prolonged the ovarian lifespan of aging mice by improving follicle survival.
ILDR1
Genome-wide association meta-analysis identifies five novel loci for age-related hearing impairment.
IMPACT
Load-dependent modulation of alpha oscillations during working memory encoding and retention in young and older adults.
Using Video Telehealth to Deliver Patient-Centered Collaborative Care: The G-IMPACT Pilot.
AGING, HEART RATE VARIABILITY AND METABOLIC IMPACT OF OBESITY.
MeSH Terms
- Aging
- Autonomic Nervous System
- Autonomic Nervous System Diseases
- Female
- Heart Rate
- Humans
- Male
- Metabolic Diseases
- Metabolism
- Middle Aged
- Obesity
Keywords
- Aging
- Autonomic nervous system
- Heart rate
- Obesity, metabolically benign
- Parasympathetic nervous system
- Sympathetic nervous system
INS
Melatonin protects INS-1 pancreatic β-cells from apoptosis and senescence induced by glucotoxicity and glucolipotoxicity.
Nicotine triggers islet β cell senescence to facilitate the progression of type 2 diabetes.
MeSH Terms
- Animals
- Blotting, Western
- Calcium
- Cellular Senescence
- Diabetes Mellitus, Type 2
- Disease Progression
- Dose-Response Relationship, Drug
- Enzyme-Linked Immunosorbent Assay
- Glucose
- Insulin-Secreting Cells
- Male
- Mice
- Mice, Inbred C57BL
- Nicotine
- Reactive Oxygen Species
- Real-Time Polymerase Chain Reaction
- beta-Galactosidase
Keywords
- ROS
- islet β cells
- nicotine
- senescence
- type 2 diabetes
INSL3
Effect of Thyroxine Replacement on Leydig Cell and Sertoli Cell Function in Men with Hypothyroidism.
IP6K1
The Role of the IGF-1 Signaling Cascade in Muscle Protein Synthesis and Anabolic Resistance in Aging Skeletal Muscle.
IQGAP1
IQGAP1-dysfunction leads to induction of senescence in human vascular smooth muscle cells.
Hyaluronan-binding protein 1 (HABP1) overexpression triggers induction of senescence in fibroblasts cells.
IRF8
IRF8 induces senescence of lung cancer cells to exert its tumor suppressive function.
MeSH Terms
- A549 Cells
- Animals
- Carcinogenesis
- Carcinoma, Non-Small-Cell Lung
- Cell Movement
- Cell Proliferation
- Cellular Senescence
- Gene Expression Regulation, Neoplastic
- Heterografts
- Humans
- Interferon Regulatory Factors
- Mice
- Prognosis
- Signal Transduction
- Tumor Suppressor Proteins
Keywords
- IRF8
- NSCLC
- cell cycle arrest
- cell senescence
- tumor suppresser gene
IRS1
MicroRNA-34a causes ceramide accumulation and effects insulin signaling pathway by targeting ceramide kinase (CERK) in aging skeletal muscle.
Longevity in response to lowered insulin signaling requires glycine N-methyltransferase-dependent spermidine production.
Serine Phosphorylation of IRS1 Correlates with Aβ-Unrelated Memory Deficits and Elevation in Aβ Level Prior to the Onset of Memory Decline in AD.
MeSH Terms
- Aging
- Alzheimer Disease
- Amyloid beta-Peptides
- Amyloid beta-Protein Precursor
- Animals
- Brain
- Diabetes Mellitus, Type 2
- Humans
- Insulin
- Insulin Receptor Substrate Proteins
- Male
- Memory
- Memory Disorders
- Mice, Inbred C57BL
- Mice, Transgenic
- Phosphorylation
- Serine
- Signal Transduction
Keywords
- AMPK
- Alzheimer’s disease
- Aβ
- IRS1
- aging
- diabetes
- energy depletion
- hippocampus
- memory decline
- serine phosphorylation
IRS2
Effects of Heshouwuyin on gene expression of the insulin/IGF signalling pathway in rat testis and spermatogenic cells.
ITGA3
A transcriptomic analysis of serial-cultured, tonsil-derived mesenchymal stem cells reveals decreased integrin α3 protein as a potential biomarker of senescent cells.
ITGA5
Kaempferol alleviates the reduction of developmental competence during aging of porcine oocytes.
MeSH Terms
- Animals
- Blastocyst
- Cellular Senescence
- Embryo Culture Techniques
- Embryo, Mammalian
- Embryonic Development
- Female
- Integrins
- Kaempferols
- Mitochondria
- Nanog Homeobox Protein
- Octamer Transcription Factor-3
- Oocytes
- Oxidative Stress
- RNA, Messenger
- Reactive Oxygen Species
- Swine
Keywords
- embryonic development
- kaempferol
- oocyte aging
- porcine
ITGAM
Comparative Analysis of Gene Expression Patterns for Oral Epithelium-Related Functions with Aging.
IVD
MicroRNAs in Intervertebral Disc Degeneration, Apoptosis, Inflammation, and Mechanobiology.
A step-by-step protocol for isolation of murine nucleus pulposus cells.
Caspase-3 knockout inhibits intervertebral disc degeneration related to injury but accelerates degeneration related to aging.
Finite element and deformation analyses predict pattern of bone failure in loaded zebrafish spines.
Improvement in determining the risk of damage to the human lumbar functional spinal unit considering age, height, weight and sex using a combination of FEM and RSM.
MeSH Terms
- Adult
- Age Factors
- Aging
- Analysis of Variance
- Biomechanical Phenomena
- Body Height
- Body Mass Index
- Body Weight
- Cortical Bone
- Female
- Finite Element Analysis
- Humans
- Imaging, Three-Dimensional
- Intervertebral Disc
- Lumbar Vertebrae
- Male
- Models, Biological
- Range of Motion, Articular
- Risk Factors
- Sex Characteristics
Keywords
- Age
- Biomechanics
- Body mass index (BMI)
- Finite element method (FEM)
- Functional spinal unit (FSU)
- Height
- Response surface method (RSM)
- Sex
- Weight
In vivo contrast-enhanced microCT for the monitoring of mouse thoracic, lumbar, and coccygeal intervertebral discs.
JAK1
Irradiation-induced senescence of bone marrow mesenchymal stem cells aggravates osteogenic differentiation dysfunction via paracrine signaling.
MeSH Terms
- Bone Resorption
- Cell Cycle Checkpoints
- Cell Differentiation
- Cell Proliferation
- Cellular Senescence
- DNA Damage
- Gene Expression Regulation, Developmental
- Histones
- Humans
- Janus Kinase 1
- Mesenchymal Stem Cells
- Mitochondria
- Osteogenesis
- Paracrine Communication
- Radiation
- Reactive Oxygen Species
- STAT3 Transcription Factor
- Signal Transduction
Keywords
- SASP
- bone marrow mesenchymal stem cells
- cellular senescence
- irradiation
- osteogenic differentiation
The Upregulation of Toll-Like Receptor 3 via Autocrine IFN-β Signaling Drives the Senescence of Human Umbilical Cord Blood-Derived Mesenchymal Stem Cells Through JAK1.
JAK2
Senescence in Monocytes Facilitates Dengue Virus Infection by Increasing Infectivity.
Quercetin Directly Targets JAK2 and PKCδ and Prevents UV-Induced Photoaging in Human Skin.
MeSH Terms
- Antioxidants
- Cell Line
- Cells, Cultured
- Cyclooxygenase 2
- Humans
- Janus Kinase 2
- MAP Kinase Signaling System
- Matrix Metalloproteinase 1
- NF-kappa B
- Protein Kinase C-delta
- Quercetin
- STAT3 Transcription Factor
- Skin
- Skin Aging
- Transcription Factor AP-1
- Ultraviolet Rays
Keywords
- JAK2
- PKC-delta
- quercetin
- skin aging
[Red blood cell lifespan detected by endogenous carbon monoxide breath test in patients with polycythemia vera].
Roles of JAK2 in Aging, Inflammation, Hematopoiesis and Malignant Transformation.
JUN
Age-Onset Phosphorylation of a Minor Actin Variant Promotes Intestinal Barrier Dysfunction.
MeSH Terms
- Actin Cytoskeleton
- Actins
- Aging
- Animals
- Binding Sites
- Caenorhabditis elegans
- Caenorhabditis elegans Proteins
- Intercellular Junctions
- Intestinal Mucosa
- JNK Mitogen-Activated Protein Kinases
- Phosphorylation
- Protein Phosphatase 1
- Transcription Factors
- Troponin
Keywords
- HSF-1
- actin
- aging
- barrier
- intestine
- junctions
- kinase
- pathogenesis
- phosphorylation
- stress
JUNB
Promotion of cellular senescence by THG-1/TSC22D4 knockout through activation of JUNB.
MeSH Terms
- Cell Line, Tumor
- Cell Proliferation
- Cellular Senescence
- Cyclin-Dependent Kinase Inhibitor p21
- Gene Expression Regulation, Neoplastic
- Gene Knockout Techniques
- HEK293 Cells
- Humans
- Transcription Factors
- Transcription, Genetic
- Up-Regulation
Keywords
- Cellular senescence
- JUNB
- P21(CDKN1A)
- THG-1(TSC22D4)
KAT6B
Aging-associated decrease in the histone acetyltransferase KAT6B is linked to altered hematopoietic stem cell differentiation.
KCNK2
Brain age prediction using deep learning uncovers associated sequence variants.
MeSH Terms
- Adolescent
- Adult
- Aged
- Aged, 80 and over
- Aging
- Brain
- Databases, Factual
- Deep Learning
- Genome-Wide Association Study
- Humans
- Iceland
- Magnetic Resonance Imaging
- Middle Aged
- Neural Networks, Computer
- Neuropsychological Tests
- Polymorphism, Single Nucleotide
- United Kingdom
- Young Adult
KCNQ4
Guanylyl Cyclase A/cGMP Signaling Slows Hidden, Age- and Acoustic Trauma-Induced Hearing Loss.
KCTD12
The association between poverty and gene expression within peripheral blood mononuclear cells in a diverse Baltimore City cohort.
KDM2A
SIRT6 mono-ADP ribosylates KDM2A to locally increase H3K36me2 at DNA damage sites to inhibit transcription and promote repair.
KDM2B
Identification of Structural Elements of the Lysine Specific Demethylase 2B CxxC Domain Associated with Replicative Senescence Bypass in Primary Mouse Cells.
KDM3A
KDM3A and KDM4C Regulate Mesenchymal Stromal Cell Senescence and Bone Aging via Condensin-mediated Heterochromatin Reorganization.
KEAP1
NRF2 pathway activation by KEAP1 inhibition attenuates the manifestation of aging phenotypes in salivary glands.
Adaptation of the master antioxidant response connects metabolism, lifespan and feather development pathways in birds.
MeSH Terms
- Adaptation, Physiological
- Animals
- Antioxidants
- Basal Metabolism
- Biological Evolution
- Birds
- Cell Nucleus
- Feathers
- Fibroblasts
- Genomics
- Glutathione Transferase
- HEK293 Cells
- Humans
- Kelch-Like ECH-Associated Protein 1
- Longevity
- NF-E2-Related Factor 2
- Oxidative Stress
- Phylogeny
- Proteasome Endopeptidase Complex
- Protein Binding
- Protein Transport
- Ubiquitination
- Up-Regulation
KIN
The noncanonical small heat shock protein HSP-17 from [i]Caenorhabditis elegans[/i] is a selective protein aggregase.
MeSH Terms
- Animals
- Caenorhabditis elegans
- Caenorhabditis elegans Proteins
- Casein Kinase I
- Heat-Shock Proteins, Small
- Longevity
- Malate Dehydrogenase
- Peptides
- Protein Aggregates
- Protein Folding
- RNA Interference
- RNA, Small Interfering
- Recombinant Proteins
Keywords
- Caenorhabditis elegans (C. elegans)
- chaperone
- protein aggregates
- protein aggregation
- protein folding
- proteostasis
- selective protein aggregase
- small heat shock protein (sHsp)
KIT
Prediction of ovarian aging using ovarian expression of BMP15, GDF9, and C-KIT.
KLF2
KLF2 induces the senescence of pancreatic cancer cells by cooperating with FOXO4 to upregulate p21.
MeSH Terms
- Animals
- Carcinogenesis
- Cell Cycle Proteins
- Cell Line
- Cells, Cultured
- Cellular Senescence
- Cyclin-Dependent Kinase Inhibitor p21
- Forkhead Transcription Factors
- Kruppel-Like Transcription Factors
- Male
- Mice
- Mice, Nude
- Pancreatic Neoplasms
- Protein Binding
- Up-Regulation
Keywords
- FOXO4
- KLF2
- Pancreatic cancer
- Senescence
KLF4
Extracellular Vesicles from Healthy Cells Improves Cell Function and Stemness in Premature Senescent Stem Cells by miR-302b and HIF-1α Activation.
Soluble klotho regulates the function of salivary glands by activating KLF4 pathways.
MeSH Terms
- Animals
- Cells, Cultured
- Down-Regulation
- Gene Expression Regulation
- Glucuronidase
- HEK293 Cells
- Humans
- Kruppel-Like Transcription Factors
- Membrane Proteins
- Mice
- Mice, Knockout
- Nuclear Proteins
- RNA Interference
- RNA, Small Interfering
- Salivary Glands
Keywords
- KLF4
- aging
- salivary gland
- soluble klotho
KLF6
Krüppel-Like Factor 6 Is Required for Oxidative and Oncogene-Induced Cellular Senescence.
KRAS
Chemical Pathology of Homocysteine VIII. Effects of Tocotrienol, Geranylgeraniol, and Squalene on Thioretinaco Ozonide, Mitochondrial Permeability, and Oxidative Phosphorylation in Arteriosclerosis, Cancer, Neurodegeneration and Aging.
Keywords
- adenosine triphosphate
- aging
- antioxidant
- apoptosis
- atherogenesis
- cancer
- carcinogenesis
- cholesterol
- free radical
- geraniol
- geranylgeraniol
- homocysteine
- menoquinone
- mitochondrial dysfunction
- mitochondrial membrane potential
- mitochondrial permeability transition pore
- mitophagy
- neuro-degeneration
- oxidative phosphorylation
- oxidative stress
- squalene
- statin
- stellate cells
- testosterone
- thioretinaco ozonide
- thioretinamide
- tocopherol
- tocotrienol
- ubiquinone
Senescence-Induced Vascular Remodeling Creates Therapeutic Vulnerabilities in Pancreas Cancer.
MeSH Terms
- Aging
- Animals
- CD8-Positive T-Lymphocytes
- Carcinoma, Pancreatic Ductal
- Cell Line, Tumor
- Cell Proliferation
- Cyclin-Dependent Kinase 4
- Cyclin-Dependent Kinase 6
- Gene Expression Regulation, Neoplastic
- Genes, ras
- Humans
- Immunotherapy
- MAP Kinase Signaling System
- Mice
- Pancreatic Neoplasms
- Retinoblastoma Protein
- Signal Transduction
- Tumor Microenvironment
- Vascular Remodeling
Keywords
- T cells
- chemotherapy resistance
- endothelial cell activation
- immunotherapy
- pancreatic cancer
- senescence
- senescence-associated secretory phenotype
- targeted therapy
- tumor microenvironment
- vascular biology
L1CAM
Glioma malignancy is linked to interdependent and inverse AMOG and L1 adhesion molecule expression.
MeSH Terms
- Adenosine Triphosphatases
- Apoptosis
- Biomarkers
- Brain Neoplasms
- Cation Transport Proteins
- Cell Adhesion
- Cell Adhesion Molecules, Neuronal
- Cell Line, Tumor
- Cellular Senescence
- Gene Expression Profiling
- Gene Expression Regulation, Neoplastic
- Glioblastoma
- Humans
- Immunohistochemistry
- Neural Cell Adhesion Molecule L1
- RNA, Small Interfering
- Signal Transduction
Keywords
- AMOG
- Apoptosis
- Glioma
- Human
- L1CAM
- Senescence
- Therapy
LAG3
T Cell Transcriptional Profiling and Immunophenotyping Uncover LAG3 as a Potential Significant Target of Immune Modulation in Multiple Myeloma.
LAMP1
Differential accumulation of storage bodies with aging defines discrete subsets of microglia in the healthy brain.
LBP
Lipopolysaccharide binding protein is associated with CVD risk in older adults.
Aging-related liver degeneration is associated with increased bacterial endotoxin and lipopolysaccharide binding protein levels.
MeSH Terms
- Acute-Phase Proteins
- Aging
- Animals
- Apoptosis
- Biomarkers
- Carrier Proteins
- Endotoxins
- Female
- Gene Expression Regulation
- Glucose
- Inflammation
- Insulin Receptor Substrate Proteins
- Liver
- Liver Cirrhosis
- Malate Dehydrogenase
- Male
- Membrane Glycoproteins
- Mice
- Mice, Inbred C57BL
- Mice, Knockout
- RNA, Messenger
- Receptor, Insulin
- Toll-Like Receptor 4
Keywords
- Tlr-4 signaling
- aging
- bacterial endotoxin
- lipopolysaccharide binding protein
- liver degeneration
Biomarkers of leaky gut are related to inflammation and reduced physical function in older adults with cardiometabolic disease and mobility limitations.
MeSH Terms
- Aged
- Aging
- Biomarkers
- Exercise Therapy
- Female
- Follow-Up Studies
- Humans
- Inflammation
- Male
- Metabolic Syndrome
- Middle Aged
- Mobility Limitation
- Motor Activity
- Obesity
- Retrospective Studies
- Weight Loss
Keywords
- Ageing
- Lipopolysaccharide-binding protein
- Microbial translocation
- Physical function
Needle-shaped amyloid deposition in rat mammary gland: evidence of a novel amyloid fibril protein.
Effects of Lycium barbarum Polysaccharides on Health and Aging of [i]C. elegans[/i] Depend on [i]daf-12/daf-16[/i].
LBR
Lamin B receptor: role on chromatin structure, cellular senescence and possibly aging.
The impact of age beyond ploidy: outcome data from 8175 euploid single embryo transfers.
The role of lamin B receptor in the regulation of senescence-associated secretory phenotype (SASP).
Lamin B receptor plays a key role in cellular senescence induced by inhibition of the proteasome.
LEP
Age- and Sex-Specific Changes in Lower-Limb Muscle Power Throughout the Lifespan.
The Copenhagen Sarcopenia Study: lean mass, strength, power, and physical function in a Danish cohort aged 20-93 years.
LGR6
Effect of defensins-containing eye cream on periocular rhytids and skin quality.
LHCGR
Comparative Study of the Steroidogenic Effects of Human Chorionic Gonadotropin and Thieno[2,3-D]pyrimidine-Based Allosteric Agonist of Luteinizing Hormone Receptor in Young Adult, Aging and Diabetic Male Rats.
LMNA
Metformin alters peripheral blood mononuclear cells (PBMC) senescence biomarkers gene expression in type 2 diabetic patients.
Protein structural and mechanistic basis of progeroid laminopathies.
Progerin Expression Induces Inflammation, Oxidative Stress and Senescence in Human Coronary Endothelial Cells.
The JAK1/2 inhibitor ruxolitinib delays premature aging phenotypes.
Pharmacotherapy to gene editing: potential therapeutic approaches for Hutchinson-Gilford progeria syndrome.
Long term breeding of the Lmna G609G progeric mouse: Characterization of homozygous and heterozygous models.
LMNB1
SIRT1 - a new mammalian substrate of nuclear autophagy.
Cellular senescence as a response to multiwalled carbon nanotube (MWCNT) exposure in human mesothelial cells.
Inflammatory Drivers of Cardiovascular Disease: Molecular Characterization of Senescent Coronary Vascular Smooth Muscle Cells.
LOX
12-LOX catalyzes the oxidation of 2-arachidonoyl-lysolipids in platelets generating eicosanoid-lysolipids that are attenuated by iPLA γ knockout.
LOXL1
A blackberry-dill extract combination synergistically increases skin elasticity.
LOXL2
Lysyl Oxidase-Like 2 Protects against Progressive and Aging Related Knee Joint Osteoarthritis in Mice.
MeSH Terms
- Adenoviridae
- Aging
- Amino Acid Oxidoreductases
- Animals
- Arthritis, Experimental
- Cartilage, Articular
- Disease Models, Animal
- Disease Progression
- Gene Expression
- Gene Transfer Techniques
- Genetic Vectors
- Interleukin-1beta
- Mice
- Mice, Transgenic
- NF-kappa B
- Osteoarthritis, Knee
- Transduction, Genetic
Keywords
- Lysyl oxidase like-2
- adenovirus delivery
- anabolic response
- articular cartilage
- knee joint
- osteoarthritis
- regeneration
LPA
Ginseng gintonin, aging societies, and geriatric brain diseases.
Late-life related subtypes of depression - a data-driven approach on cognitive domains and physical frailty.
Does sedentary time increase in older adults in the days following participation in intense exercise?
Association of Long-term Exposure to Elevated Lipoprotein(a) Levels With Parental Life Span, Chronic Disease-Free Survival, and Mortality Risk: A Mendelian Randomization Analysis.
Elevated Autotaxin and LPA Levels During Chronic Viral Hepatitis and Hepatocellular Carcinoma Associate with Systemic Immune Activation.
Lysophosphatidic acid receptor LPA prevents oxidative stress and cellular senescence in Hutchinson-Gilford progeria syndrome.
Associations of Sedentary and Physically-Active Behaviors With Cognitive-Function Decline in Community-Dwelling Older Adults: Compositional Data Analysis From the NEIGE Study.
Validation and comparison of two automated methods for quantifying brain white matter hyperintensities of presumed vascular origin.
The Sedentary Time and Physical Activity Levels on Physical Fitness in the Elderly: A Comparative Cross Sectional Study.
Light-Intensity Physical Activity in a Large Prospective Cohort of Older US Adults: A 21-Year Follow-Up of Mortality.
MeSH Terms
- Aged
- Cardiovascular Diseases
- Cohort Studies
- Exercise
- Female
- Follow-Up Studies
- Humans
- Leisure Activities
- Male
- Middle Aged
- Mortality
- Neoplasms
- Proportional Hazards Models
- Prospective Studies
- Respiratory Tract Diseases
- Risk Factors
- Surveys and Questionnaires
- United States
Keywords
- Aging
- Cancer prevention study
- Leisure time physical activity
- Light-intensity physical activity
LPL
Survival analyses in Holstein cows considering direct disease diagnoses and specific SNP marker effects.
Influence of common health disorders on the length of productive life and stayability in German Holstein cows.
LPO
[Features of the changes in lipid peroxidation and activity of Na+/K+-ATPase in the brain of the aged rats in the conditions of two-vessel cerebral ischemia/reperfusion.]
MeSH Terms
- Aging
- Animals
- Brain Ischemia
- Disease Models, Animal
- Lipid Peroxidation
- Rats
- Reperfusion Injury
- Sodium-Potassium-Exchanging ATPase
Keywords
- Na+/K+-ATPase
- aging
- brain
- lipid peroxidation
- oxidative stress
- stroke
LRP1
Drug Targeting of Plasminogen Activator Inhibitor-1 Inhibits Metabolic Dysfunction and Atherosclerosis in a Murine Model of Metabolic Syndrome.
MeSH Terms
- Animals
- Atherosclerosis
- Cellular Senescence
- Diet, Western
- Disease Models, Animal
- Indoleacetic Acids
- Macrophages
- Metabolic Syndrome
- Mice
- Mice, Knockout
- Obesity
- Plaque, Atherosclerotic
- Plasminogen Activator Inhibitor 1
- Receptors, LDL
Keywords
- atherosclerosis
- cellular senescence
- fibrinolysis
- metabolic syndrome
- muscle, smooth
- obesity
- plasminogen activator inhibitor-1
LRP4
Multiple MuSK signaling pathways and the aging neuromuscular junction.
LRP6
Low-density lipoprotein receptor-related protein 6-mediated signaling pathways and associated cardiovascular diseases: diagnostic and therapeutic opportunities.
LRRK2
Accelerated telomere shortening independent of LRRK2 variants in Chinese patients with Parkinson's disease.
The effect of LRRK2 loss-of-function variants in humans.
MeSH Terms
- Adult
- Aged
- Aged, 80 and over
- Biological Specimen Banks
- Cell Line
- Embryonic Stem Cells
- Female
- Gain of Function Mutation
- Heterozygote
- Humans
- Leucine-Rich Repeat Serine-Threonine Protein Kinase-2
- Longevity
- Loss of Function Mutation
- Lymphocytes
- Male
- Middle Aged
- Myocytes, Cardiac
- Parkinson Disease
- Phenotype
Parkinson's disease-related Leucine-rich repeat kinase 2 modulates nuclear morphology and genomic stability in striatal projection neurons during aging.
Autophagy and LRRK2 in the Aging Brain.
LSS
Surgical results in older patients with lumbar spinal stenosis according to gait speed in relation to the diagnosis for sarcopenia.
Streamlining an existing hip fracture patient pathway in an acute tertiary adult Irish hospital to improve patient experience and outcomes.
MeSH Terms
- Aged
- Aged, 80 and over
- Delivery of Health Care, Integrated
- Geriatrics
- Hip Fractures
- Hospitals, Teaching
- Humans
- Ireland
- Length of Stay
- Nerve Block
- Orthopedics
- Pain Management
- Total Quality Management
- Treatment Outcome
Keywords
- Lean Six Sigma
- healthcare outcomes
- hip fracture care
- integrated care pathways
- interdisciplinary working
- process improvement
LTA
Lipoteichoic acid from the cell wall of a heat killed Lactobacillus paracasei D3-5 ameliorates aging-related leaky gut, inflammation and improves physical and cognitive functions: from C. elegans to mice.
The change of pain classes over time: a latent transition analysis.
LY6D
LY6D-induced macropinocytosis as a survival mechanism of senescent cells.
MAG
Exploration of life satisfaction of Korean people with sensory impairments across the lifespan.
MALT1
MALT-1 mediates IL-17 neural signaling to regulate C. elegans behavior, immunity and longevity.
MeSH Terms
- Animals
- Behavior, Animal
- Caenorhabditis elegans
- Caenorhabditis elegans Proteins
- Gene Expression Regulation
- Green Fluorescent Proteins
- Immunity
- Interleukin-17
- Interneurons
- Longevity
- Models, Biological
- Mucosa-Associated Lymphoid Tissue Lymphoma Translocation 1 Protein
- Neurons
- Oxygen
- Signal Transduction
- Subcellular Fractions
- Transgenes
MALT1-Deficient Mice Develop Atopic-Like Dermatitis Upon Aging.
MeSH Terms
- Age Factors
- Animals
- CTLA-4 Antigen
- Cytokines
- Dermatitis, Atopic
- Disease Models, Animal
- Disease Susceptibility
- Gene Expression
- Genetic Predisposition to Disease
- Immunoglobulin E
- Lymphocyte Activation
- Mice
- Mice, Knockout
- Mucosa-Associated Lymphoid Tissue Lymphoma Translocation 1 Protein
- Skin
- T-Lymphocyte Subsets
Keywords
- MALT1
- Th2
- Tregs
- aging
- atopic dermatitis
- lymphocytes
- skin inflammation
MAP2
Protective effects of ischemic preconditioning against neuronal apoptosis and dendritic injury in the hippocampus are age-dependent.
MAP4K3
MAP4K3/GLK in autoimmune disease, cancer and aging.
MAPK1
Purified Vitexin Compound 1 Inhibits UVA-Induced Cellular Senescence in Human Dermal Fibroblasts by Binding Mitogen-Activated Protein Kinase 1.
MAPKAPK2
Quantitative In Vivo Proteomics of Metformin Response in Liver Reveals AMPK-Dependent and -Independent Signaling Networks.
MeSH Terms
- AMP-Activated Protein Kinases
- Animals
- Calcium
- Cell Line
- Endocytosis
- HEK293 Cells
- Homeostasis
- Humans
- Intracellular Signaling Peptides and Proteins
- Liver
- Metformin
- Mice
- Phosphorylation
- Protein Kinase C
- Protein-Serine-Threonine Kinases
- Proteomics
- Signal Transduction
Keywords
- AMPK3
- LKB1
- PKD1
- STIM1
- aging
- calcium
- diabetes
- kinases
- liver
- metformin
MAPT
Association of relative brain age with tobacco smoking, alcohol consumption, and genetic variants.
A blood-based nutritional risk index explains cognitive enhancement and decline in the multidomain Alzheimer prevention trial.
Longitudinal associations of physical activity levels with morphological and functional changes related with aging: The MAPT study.
Ageing and amyloidosis underlie the molecular and pathological alterations of tau in a mouse model of familial Alzheimer's disease.
Revisiting the intersection of amyloid, pathologically modified tau and iron in Alzheimer's disease from a ferroptosis perspective.
MATN3
Mice Lacking the Matrilin Family of Extracellular Matrix Proteins Develop Mild Skeletal Abnormalities and Are Susceptible to Age-Associated Osteoarthritis.
MeSH Terms
- Aging
- Animals
- Cell Proliferation
- Cells, Cultured
- Chondrocytes
- Disease Models, Animal
- Female
- Gene Knockout Techniques
- Humans
- Male
- Matrilin Proteins
- Mice
- Mice, Knockout
- Microscopy, Atomic Force
- Muscle, Skeletal
- Osteoarthritis
Keywords
- articular cartilage
- bone development
- cartilage
- matrilin
- osteoarthritis
MB
Probing menstrual bloodstain aging with fluorescence spectroscopy.
Effect of physical exercise and medication on enhancing cognitive function in older adults with vascular risk.
A novel indenone derivative selectively induces senescence in MDA-MB-231 (breast adenocarcinoma) cells.
MeSH Terms
- Antineoplastic Agents
- Breast Neoplasms
- Catalysis
- Cell Line, Tumor
- Cell Survival
- Cellular Senescence
- Cyclin-Dependent Kinase Inhibitor p21
- Down-Regulation
- Female
- G1 Phase Cell Cycle Checkpoints
- Humans
- Palladium
- Sulfonamides
- Survivin
- Tumor Suppressor Protein p53
- Up-Regulation
Keywords
- Cell cycle arrest
- Novel indenone derivative
- Senescence
- Triple-negative breast cancer
Improved Autophagic Flux in Escapers from Doxorubicin-Induced Senescence/Polyploidy of Breast Cancer Cells.
Lifespan regulation in α/β posterior neurons of the fly mushroom bodies by Rab27.
Tailored Functionalized Magnetic Nanoparticles to Target Breast Cancer Cells Including Cancer Stem-Like Cells.
"Mitotic Slippage" and Extranuclear DNA in Cancer Chemoresistance: A Focus on Telomeres.
Diversity of the Senescence Phenotype of Cancer Cells Treated with Chemotherapeutic Agents.
MeSH Terms
- Antineoplastic Agents
- Cell Proliferation
- Cellular Senescence
- Cyclin-Dependent Kinase Inhibitor p21
- Doxorubicin
- Fluorouracil
- Humans
- Irinotecan
- Methotrexate
- Neoplasms
- Oxaliplatin
- Paclitaxel
- Phenotype
- Tumor Cells, Cultured
Keywords
- DNA damage
- SASP
- cancer
- chemotherapy
- senescence
- senescence markers
Downregulation of the inflammatory network in senescent fibroblasts and aging tissues of the long-lived and cancer-resistant subterranean wild rodent, Spalax.
Quantification of the health-status of the Dutch Labrador retriever population.
Conjugated Physiological Resveratrol Metabolites Induce Senescence in Breast Cancer Cells: Role of p53/p21 and p16/Rb Pathways, and ABC Transporters.
MeSH Terms
- ATP-Binding Cassette Transporters
- Breast Neoplasms
- Cell Cycle Checkpoints
- Cellular Senescence
- Cyclin-Dependent Kinase Inhibitor p16
- Cyclin-Dependent Kinase Inhibitor p21
- Female
- Glucuronides
- Humans
- MCF-7 Cells
- Resveratrol
- Retinoblastoma Protein
- Signal Transduction
- Stilbenes
- Tumor Suppressor Protein p53
Keywords
- ABC transporters
- breast cancer
- deconjugation
- resveratrol metabolites
- senescence
MBP
Demyelination associated with chronic arsenic exposure in Wistar rats.
MeSH Terms
- Aging
- Amyloid beta-Protein Precursor
- Animals
- Arsenic Poisoning
- Arsenites
- Axons
- Corpus Callosum
- Demyelinating Diseases
- Diffusion Tensor Imaging
- Drinking Water
- Immunohistochemistry
- Male
- Mitochondria
- Myelin Basic Protein
- Neurofilament Proteins
- Prefrontal Cortex
- Rats
- Rats, Wistar
- Sodium Compounds
- White Matter
Keywords
- Amyloid
- Anisotropy
- Arsenic
- Axonal damage
- DTI
- Demyelination
- Development
- MRI
- Microstructure
- Mitochondria
Natural killer cells as participants in pathogenesis of rat experimental autoimmune encephalomyelitis (EAE): lessons from research on rats with distinct age and strain.
MCC
Multiple chronic conditions and risk of cognitive impairment and dementia among older Americans: findings from the Aging, Demographics, and Memory Study (ADAMS).
Behaviour consistency is a sensitive tool for distinguishing the effects of aging on physical activity.
Burden on Caregivers of Adults with Multiple Chronic Conditions: Intersectionality of Age, Gender, Education level, Employment Status, and Impact on Social Life.
MCM9
MCM8- and MCM9 Deficiencies Cause Lifelong Increased Hematopoietic DNA Damage Driving p53-Dependent Myeloid Tumors.
MeSH Terms
- Aging
- Animals
- Apoptosis
- Bone Marrow
- Cell Differentiation
- Cell Proliferation
- DNA Damage
- Gene Expression Regulation, Leukemic
- Hematologic Neoplasms
- Mice
- Mice, Knockout
- Minichromosome Maintenance Proteins
- Retinoblastoma Protein
- Signal Transduction
- Splenomegaly
- Tumor Suppressor Protein p53
Keywords
- DNA damage
- DNA repair
- MCM8
- MCM9
- cancer
- hematopoiesis
- homologous recombination
- myelodysplastic syndrome
MCU
A rare case of Epstein-Barr virus-positive mucocutaneous ulcer that developed into an intestinal obstruction: a case report.
MeSH Terms
- Aged, 80 and over
- Colon, Transverse
- Epstein-Barr Virus Infections
- Herpesvirus 4, Human
- Humans
- Intestinal Mucosa
- Intestinal Obstruction
- Male
- Ulcer
Keywords
- Aging
- Epstein–Barr virus-positive mucocutaneous ulcer (EBV-MCU)
- Immunosuppression
- Intestinal obstruction
- Surgical resection
Inhibition of Mitochondrial Calcium Overload by SIRT3 Prevents Obesity- or Age-Related Whitening of Brown Adipose Tissue.
MDH1
Oxidative Damage to the TCA Cycle Enzyme MDH1 Dysregulates Bioenergetic Enzymatic Activity in the Aged Murine Brain.
MDM2
SENEBLOC, a long non-coding RNA suppresses senescence via p53-dependent and independent mechanisms.
Disruption of Robo2-Baiap2 integrated signaling drives cystic disease.
MeSH Terms
- Animals
- Cell Differentiation
- Cell Proliferation
- Cellular Senescence
- Cilia
- Disease Models, Animal
- Epithelial Cells
- Humans
- Kidney
- Kidney Diseases, Cystic
- Mice
- Mice, Knockout
- Nerve Tissue Proteins
- Protein Binding
- Protein Domains
- Receptors, Immunologic
- Signal Transduction
- Tumor Suppressor Protein p53
Keywords
- Cellular senescence
- Development
- Genetic diseases
- Nephrology
- Signal transduction
Senescence-induced immunophenotype, gene expression and electrophysiology changes in human amniocytes.
MeSH Terms
- Amniocentesis
- Amnion
- Biomarkers
- Cell Proliferation
- Cells, Cultured
- Cellular Senescence
- Electrophysiological Phenomena
- Female
- Gene Expression Regulation
- Humans
- Immunophenotyping
- Phenotype
Keywords
- amniocyte
- automated patch-clamp
- flow cytometry
- mesenchymal stem cell
- qRT-PCR
- replicative senescence
- senescence-associated secretory phenotype
MED25
The [i]HAC1[/i] histone acetyltransferase promotes leaf senescence and regulates the expression of [i]ERF022[/i].
MEFV
The grandfather's fever.
MEOX2
Reduced expression of microRNA-130a promotes endothelial cell senescence and age-dependent impairment of neovascularization.
MET
Self-rated health in relation to fruit and vegetable consumption and physical activity among older cancer survivors.
Leisure-time physical activity volume, intensity, and duration from mid- to late-life in U.S. subpopulations by race and sex. The Atherosclerosis Risk In Communities (ARIC) Study.
Repressive H3K9me2 protects lifespan against the transgenerational burden of COMPASS activity in [i]C. elegans[/i].
MeSH Terms
- Animals
- Caenorhabditis elegans
- Caenorhabditis elegans Proteins
- Heterochromatin
- Histone-Lysine N-Methyltransferase
- Histones
- Inheritance Patterns
- Jumonji Domain-Containing Histone Demethylases
- Longevity
- Lysine
- Methylation
- Mutation
Keywords
- C. elegans
- COMPASS
- aging
- chromatin
- chromosomes
- epigenetics
- gene expression
- genetics
- genomics
- heterochromatin
- transgenerational inheritance
Influence of Anthropometrics on Step-Rate Thresholds for Moderate and Vigorous Physical Activity in Older Adults: Scientific Modeling Study.
MFI
The Influence of the Accelerated Aging Conditions on the Properties of Polyolefin Geogrids Used for Landfill Slope Reinforcement.
Changes in Physical Meat Traits, Protein Solubility, and the Microstructure of Different Beef Muscles during Post-Mortem Aging.
Effect of a low-voltage electrical stimulation on yak meat tenderness during postmortem aging.
Comparative effects of dry-aging and wet-aging on physicochemical properties and digestibility of Hanwoo beef.
MFN2
Thioredoxin protects mitochondrial structure, function and biogenesis in myocardial ischemia-reperfusion via redox-dependent activation of AKT-CREB- PGC1α pathway in aged mice.
MFN2 contributes to metabolic disorders and inflammation in the aging of rat chondrocytes and osteoarthritis.
MFSD2A
Decreased Blood Level of MFSD2a as a Potential Biomarker of Alzheimer's Disease.
MGMT
Cytotoxic and Senolytic Effects of Methadone in Combination with Temozolomide in Glioblastoma Cells.
MIA
Age, cohort, and period effects on metamemory beliefs.
Memory Age-based Stereotype Threat: Role of Locus of Control and Anxiety.
MIB1
Immunohistochemical detection of senescence markers in human sarcomas.
MIP
Inspiratory muscle training improves cerebrovascular and postural control responses during orthostatic stress in older women.
A novel multi-marker discovery approach identifies new serum biomarkers for Parkinson's disease in older people: an EXosomes in PArkiNson Disease (EXPAND) ancillary study.
Sexual dimorphism of physical activity on cognitive aging: Role of immune functioning.
Comparison of balance changes after inspiratory muscle or Otago exercise training.
MITF
Thymocid , a Standardized Black Cumin ([i]Nigella sativa[/i]) Seed Extract, Modulates Collagen Cross-Linking, Collagenase and Elastase Activities, and Melanogenesis in Murine B16F10 Melanoma Cells.
HuRdling Senescence: HuR Breaks BRAF-Induced Senescence in Melanocytes and Supports Melanoma Growth.
MLH1
The somatic mutation landscape of the human body.
MLKL
Remifentanil preconditioning protects against hypoxia-induced senescence and necroptosis in human cardiac myocytes [i]in vitro[/i].
MLN
Age-Dependent Decrease in the Induction of Regulatory T Cells Is Associated With Decreased Expression of RALDH2 in Mesenteric Lymph Node Dendritic Cells.
MMD
Association between a Deficit Accumulation Frailty Index and Mobility Outcomes in Older Adults: Secondary Analysis of the Lifestyle Interventions and Independence for Elders (LIFE) Study.
Impact of Anticholinergic Medication Burden on Mobility and Falls in the Lifestyle Interventions for Elders (LIFE) Study.
Impact and Lessons From the Lifestyle Interventions and Independence for Elders (LIFE) Clinical Trials of Physical Activity to Prevent Mobility Disability.
MME
Geriatric Opioid Harm Reduction: Interprofessional Student Learning Outcomes.
Effectiveness of local anesthetic injection in geriatric patients following operative management of proximal and diaphyseal femur fracture.
MeSH Terms
- Aged
- Aged, 80 and over
- Analgesics, Opioid
- Anesthetics, Local
- Delirium
- Female
- Femoral Fractures
- Fracture Fixation, Internal
- Geriatrics
- Humans
- Injections, Intra-Articular
- Intraoperative Care
- Male
- Pain Management
- Pain, Postoperative
- Retrospective Studies
Keywords
- Geriatrics
- Hip fracture
- Local anesthetic
- Narcotics
MMP1
Reacquisition of a spindle cell shape does not lead to the restoration of a youthful state in senescent human skin fibroblasts.
A novel multifunctional skin care formulation with a unique blend of antipollution, brightening and antiaging active complexes.
MMP13
Aging aggravates intervertebral disc degeneration by regulating transcription factors toward chondrogenesis.
MeSH Terms
- Aging
- Animals
- Antigens, Differentiation
- Chondrocytes
- Chondrogenesis
- Core Binding Factor Alpha 1 Subunit
- Fetal Proteins
- Gene Expression Regulation
- Intervertebral Disc Degeneration
- Mice
- Mice, Transgenic
- Sp7 Transcription Factor
- T-Box Domain Proteins
Keywords
- Wnt/β-catenin/LRPs
- biomechanics
- genetic animal models
- osterix
MOS
Effect of mannan oligosaccharides on the microbiota and productivity parameters of Litopenaeus vannamei shrimp under intensive cultivation in Ecuador.
Predictors of health-related quality of life among older adults living with HIV in Thailand: results from the baseline and follow-up surveys.
Comparison of health-related quality of life between the Han and Yi ethnicity elderly in the Yi autonomous areas of Yunnan Province.
Mannan oligosaccharide increases the growth performance, immunity and resistance capability against Vibro Parahemolyticus in juvenile abalone Haliotis discus hannai Ino.
MeSH Terms
- Animal Feed
- Animals
- Antioxidants
- Diet
- Dietary Supplements
- Dose-Response Relationship, Drug
- Gastropoda
- Immunity, Innate
- Longevity
- Mannans
- Oligosaccharides
- Vibrio parahaemolyticus
Keywords
- Abalone
- Antioxidation
- Bacterial challenge
- Disease resistance
- Growth
- Immunity
- Mannan oligosaccharide
MPHOSPH6
Genome-wide Association Analysis in Humans Links Nucleotide Metabolism to Leukocyte Telomere Length.
MPI
Age-related decline of lymphatic drainage from the eye: A noninvasive in vivo photoacoustic tomography study.
Interest of the multidimensional prognostic index (MPI) as an assessment tool in hospitalized patients in geriatrics.
MRE11
Chromosomal alterations among age-related haematopoietic clones in Japan.
MeSH Terms
- Aged, 80 and over
- Aging
- Alleles
- Cell Lineage
- Chromosome Aberrations
- Chromosomes, Human
- Clone Cells
- Cohort Studies
- Female
- Genetic Loci
- Genome, Human
- Hematopoiesis
- Hematopoietic Stem Cells
- Humans
- Japan
- Leukemia, Lymphocytic, Chronic, B-Cell
- Leukemia, T-Cell
- Male
- Mosaicism
- Mutation
- United Kingdom
MSC
Rejuvenation of Senescent Endothelial Progenitor Cells by Extracellular Vesicles Derived From Mesenchymal Stromal Cells.
Keywords
- BM, bone marrow
- CVD, cardiovascular disease
- EC, endothelial cell
- EPC, endothelial progenitor cell
- EV, extracellular vesicle
- FBS, fetal bovine serum
- MEM, minimum essential medium
- MI, myocardial infarction
- MSC, mesenchymal stromal cell
- NTA, nanotracking analysis
- PBS, phosphate-buffered saline
- TEV, tailored extracellular vesicle
- VEGF, vascular endothelial growth factor
- acellular
- angiogenesis
- extracellular vesicles
- lin− BMC, lineage negative bone marrow cell
- miR, microRNA
- qPCR, quantitative transcription polymerase chain reaction
- regeneration
- senescence
Extracellular vesicles derived from bone marrow mesenchymal stem cells enhance myelin maintenance after cortical injury in aged rhesus monkeys.
TPP1 Enhances the Therapeutic Effects of Transplanted Aged Mesenchymal Stem Cells in Infarcted Hearts via the MRE11/AKT Pathway.
Aging-Affected MSC Functions and Severity of Periodontal Tissue Destruction in a Ligature-Induced Mouse Periodontitis Model.
Human placenta-derived mesenchymal stem cells stimulate ovarian function via miR-145 and bone morphogenetic protein signaling in aged rats.
Mesenchymal Stromal Cells as Critical Contributors to Tissue Regeneration.
The biology of human hair greying.
[i]Tsc1[/i] Regulates the Proliferation Capacity of Bone-Marrow Derived Mesenchymal Stem Cells.
The role of mitochondrial dysfunction in mesenchymal stem cell senescence.
Metabolic syndrome increases senescence-associated micro-RNAs in extracellular vesicles derived from swine and human mesenchymal stem/stromal cells.
Functional heterogeneity of mesenchymal stem cells from natural niches to culture conditions: implications for further clinical uses.
Functional crosstalk between mTORC1/p70S6K pathway and heterochromatin organization in stress-induced senescence of MSCs.
Increased cellular senescence in the murine and human stenotic kidney: Effect of mesenchymal stem cells.
Intrinsic Type 1 Interferon (IFN1) Profile of Uncultured Human Bone Marrow CD45 CD271 Multipotential Stromal Cells (BM-MSCs): The Impact of Donor Age, Culture Expansion and IFNα and IFNβ Stimulation.
Facial rejuvenation using stem cell conditioned media combined with skin needling: A split-face comparative study.
Mesenchymal Stem Cell Senescence and Rejuvenation: Current Status and Challenges.
The changing epigenetic landscape of Mesenchymal Stem/Stromal Cells during aging.
Dual Role of Autophagy in Regulation of Mesenchymal Stem Cell Senescence.
Molecular Aspects of Adipose-Derived Stromal Cell Senescence in a Long-Term Culture: A Potential Role of Inflammatory Pathways.
Human Obesity Induces Dysfunction and Early Senescence in Adipose Tissue-Derived Mesenchymal Stromal/Stem Cells.
miR-155-5p inhibition rejuvenates aged mesenchymal stem cells and enhances cardioprotection following infarction.
Mesenchymal Stem Cell Derived Extracellular Vesicles in Aging.
Molecular Mechanisms Contributing to Mesenchymal Stromal Cell Aging.
Inhibition of DNA Methyltransferase by RG108 Promotes Pluripotency-Related Character of Porcine Bone Marrow Mesenchymal Stem Cells.
Extracellular Vesicles of Stem Cells to Prevent BRONJ.
Ginsenoside Rg1 as an Effective Regulator of Mesenchymal Stem Cells.
The Importance of Stem Cell Senescence in Regenerative Medicine.
Control of mesenchymal stem cell biology by histone modifications.
Impact of mesenchymal stem cell senescence on inflammaging.
Late Rescue Therapy with Cord-Derived Mesenchymal Stromal Cells for Established Lung Injury in Experimental Bronchopulmonary Dysplasia.
Low-Level Radiofrequency Exposure Does Not Induce Changes in MSC Biology: An in vitro Study for the Prevention of NIR-Related Damage.
Macrophage migration inhibitory factor rejuvenates aged human mesenchymal stem cells and improves myocardial repair.
MeSH Terms
- Adolescent
- Aged
- Aged, 80 and over
- Aging
- Animals
- Animals, Newborn
- Cellular Senescence
- Humans
- Macrophage Migration-Inhibitory Factors
- Mesenchymal Stem Cell Transplantation
- Mesenchymal Stem Cells
- Myocardial Infarction
- Myocardium
- Myocytes, Cardiac
- Rats
- Rats, Sprague-Dawley
- Young Adult
Keywords
- macrophage migration inhibitory factor
- mesenchymal stem cells
- myocardial infarction
- rejuvenation
- senescence
Influence of olive oil and its components on mesenchymal stem cell biology.
Epigenetic Regulation of Mesenchymal Stem Cell Homeostasis.
Effects of high glucose conditions on the expansion and differentiation capabilities of mesenchymal stromal cells derived from rat endosteal niche.
MeSH Terms
- Adipogenesis
- Animals
- Biomarkers
- Bone Regeneration
- Bone and Bones
- Cell Differentiation
- Cell Proliferation
- Cells, Cultured
- Cellular Senescence
- Diabetes Mellitus, Type 2
- Glucose
- Hyperglycemia
- Male
- Mesenchymal Stem Cells
- Osteogenesis
- Rats, Wistar
Keywords
- Bone repair
- Cellular senescence
- Differentiation
- Hyperglycaemia
- Mesenchymal stromal cells; Endosteum
- Type II diabetes
Autophagy inhibits the mesenchymal stem cell aging induced by D-galactose through ROS/JNK/p38 signalling.
Enhancing survival, engraftment, and osteogenic potential of mesenchymal stem cells.
Mesenchymal stem cell senescence alleviates their intrinsic and seno-suppressive paracrine properties contributing to osteoarthritis development.
MeSH Terms
- Animals
- Cell Proliferation
- Cells, Cultured
- Cellular Senescence
- Chondrocytes
- Coculture Techniques
- Collagenases
- Etoposide
- Gene Expression Regulation
- Humans
- Inflammation
- Luciferases
- Male
- Mesenchymal Stem Cells
- Mice
- Mice, Inbred Strains
- Mice, Transgenic
- Osteoarthritis
- Paracrine Communication
Keywords
- mesenchymal stem cell
- osteoarthritis
- senescence
- tissue homeostasis
Embryonic stem cell-derived extracellular vesicles enhance the therapeutic effect of mesenchymal stem cells.
MeSH Terms
- Animals
- Cell- and Tissue-Based Therapy
- Cellular Senescence
- Disease Models, Animal
- Embryonic Stem Cells
- Extracellular Vesicles
- Humans
- Insulin-Like Growth Factor I
- Mesenchymal Stem Cell Transplantation
- Mesenchymal Stem Cells
- Mice
- Mice, Inbred BALB C
- Phosphatidylinositol 3-Kinases
- Wounds and Injuries
Keywords
- Cellular senescence
- Embryonic stem cells
- Extracellular vesicles
- IGF1/PI3K/AKT pathway
- Mesenchymal stem cells
Survival of aging CD264 and CD264 populations of human bone marrow mesenchymal stem cells is independent of colony-forming efficiency.
Differential effects of extracellular vesicles from aging and young mesenchymal stem cells in acute lung injury.
Connexin43 is Dispensable for Early Stage Human Mesenchymal Stem Cell Adipogenic Differentiation But is Protective against Cell Senescence.
MeSH Terms
- Adipogenesis
- Cell Differentiation
- Cellular Senescence
- Connexin 43
- Gene Expression Regulation
- Humans
- Mesenchymal Stem Cells
- Time Factors
Keywords
- CRISPR-Cas9
- adipogenesis
- connexin43
- gap junctional intercellular communication
- mesenchymal stem cells
- oculodentodigital dysplasia
- senescence
Maintained Properties of Aged Dental Pulp Stem Cells for Superior Periodontal Tissue Regeneration.
MTHFR
One-carbon metabolism supplementation improves outcome after stroke in aged male MTHFR-deficient mice.
MeSH Terms
- Aging
- Animals
- Brain
- Choline
- Dietary Supplements
- Male
- Methylenetetrahydrofolate Reductase (NADPH2)
- Mice
- Mice, Inbred C57BL
- Recovery of Function
- Stroke
- Tetrahydrofolates
- Vitamin B 12
Keywords
- Cerebral ischemia
- Homocysteine
- Methylenetetrahydrofolate reductase
- Neurodegeneration
- Sensorimotor cortex
- Supplementation
MTOR
The roles of MTOR and miRNAs in endothelial cell senescence.
Autophagy drives fibroblast senescence through MTORC2 regulation.
The GID ubiquitin ligase complex is a regulator of AMPK activity and organismal lifespan.
MTR
Amide proton transfer-weighted magnetic resonance imaging of human brain aging at 3 Tesla.
MUC7
Reduced Salivary Mucin Binding and Glycosylation in Older Adults Influences Taste in an In Vitro Cell Model.
MYB
Transcriptome profiling of postharvest shoots identifies PheNAP2- and PheNAP3-promoted shoot senescence.
MYC
Enhanced proliferative capacity of human preadipocytes achieved by an optimized cultivating method that induces transient activity of hTERT.
MYCN
Silencing of AURKA augments the antitumor efficacy of the AURKA inhibitor MLN8237 on neuroblastoma cells.
MYSM1
MYSM1 Suppresses Cellular Senescence and the Aging Process to Prolong Lifespan.
MYT1
ESC-sEVs Rejuvenate Aging Hippocampal NSCs by Transferring SMADs to Regulate the MYT1-Egln3-Sirt1 Axis.
NACA
Age and Sex Are Strongly Correlated to the Rate and Type of Mountain Injuries Requiring Search and Rescue Missions.
NAMPT
Over-expression of Nicotinamide phosphoribosyltransferase in mouse cells confers protective effect against oxidative and ER stress-induced premature senescence.
Resistance training increases muscle NAD and NADH concentrations as well as NAMPT protein levels and global sirtuin activity in middle-aged, overweight, untrained individuals.
Differential Expression of Human N-Alpha-Acetyltransferase 40 (hNAA40), Nicotinamide Phosphoribosyltransferase (NAMPT) and Sirtuin-1 (SIRT-1) Pathway in Obesity and T2DM: Modulation by Metformin and Macronutrient Intake.
NDRG2
NDRG2 Expression Correlates with Neurofibrillary Tangles and Microglial Pathology in the Ageing Brain.
MeSH Terms
- Aged
- Aged, 80 and over
- Aging
- Alzheimer Disease
- Antigens, CD
- Antigens, Differentiation, Myelomonocytic
- Astrocytes
- Brain
- DNA Damage
- Excitatory Amino Acid Transporter 2
- Gene Expression Regulation
- Glial Fibrillary Acidic Protein
- Glutamate-Ammonia Ligase
- Humans
- Microglia
- Neurofibrillary Tangles
- Tumor Suppressor Proteins
- tau Proteins
Keywords
- N-myc downstream regulated gene 2 (NDRG2)
- ageing brain
- astrocyte
- neurofibrillary tangles
NDUFS8
Mitochondrial Complex I Mutations Predispose Drosophila to Isoflurane Neurotoxicity.
NEDD8
Targeting Protein Neddylation for Cancer Therapy.
Effective targeting of the ubiquitin-like modifier NEDD8 for lung adenocarcinoma treatment.
Pevonedistat targeted therapy inhibits canine melanoma cell growth through induction of DNA re-replication and senescence.
NEO1
Neogenin-1 distinguishes between myeloid-biased and balanced [i]Hoxb5[/i] mouse long-term hematopoietic stem cells.
NES
Mini-review: Aging of the neuroendocrine system: Insights from nonhuman primate models.
NFKB1
NFKB1 gene single-nucleotide polymorphisms: implications for graft-versus-host disease in allogeneic hematopoietic stem cell transplantation.
MeSH Terms
- Adult
- Allografts
- Disease-Free Survival
- Female
- Graft vs Host Disease
- Hematopoietic Stem Cell Transplantation
- Humans
- Male
- Middle Aged
- NF-kappa B p50 Subunit
- Pilot Projects
- Polymorphism, Single Nucleotide
- Survival Rate
Keywords
- Allogeneic hematopoietic stem cell transplantation
- Cellular senescence
- Graft-versus-host disease
- NFKB1 gene
- Senescence-associated secretory phenotype
- Single-nucleotide polymorphism
NGF
Dietary fish hydrolysate supplementation containing n-3 LC-PUFAs and peptides prevents short-term memory and stress response deficits in aged mice.
Imbalance of nerve growth factor metabolism in aging women with overactive bladder syndrome.
Parity Attenuates Intraepithelial Corneal Sensory Nerve Loss in Female Mice.
Cholinergic System and NGF Receptors: Insights from the Brain of the Short-Lived Fish [i]Nothobranchius furzeri[/i].
Retrograde axonal transport of BDNF and proNGF diminishes with age in basal forebrain cholinergic neurons.
C-SH2 point mutation converts p85β regulatory subunit of phosphoinositide 3-kinase to an anti-aging gene.
MeSH Terms
- Aging
- Animals
- Blood Glucose
- Class I Phosphatidylinositol 3-Kinases
- Class Ia Phosphatidylinositol 3-Kinase
- Female
- Forkhead Transcription Factors
- Insulin
- Male
- Mice
- Mice, Inbred C57BL
- Mice, Transgenic
- Nerve Growth Factor
- Oxidative Stress
- PC12 Cells
- Platelet-Derived Growth Factor
- Point Mutation
- Proto-Oncogene Proteins c-akt
- Rats
- src Homology Domains
NHS
Telomerase Activation to Reverse Immunosenescence in Elderly Patients With Acute Coronary Syndrome: Protocol for a Randomized Pilot Trial.
Factors associated with COVID-19-related death using OpenSAFELY.
MeSH Terms
- Adolescent
- Adult
- African Continental Ancestry Group
- Age Distribution
- Age Factors
- Aged
- Aged, 80 and over
- Aging
- Asian Continental Ancestry Group
- Asthma
- Betacoronavirus
- COVID-19
- Cohort Studies
- Coronavirus Infections
- Diabetes Mellitus
- Female
- Humans
- Hypertension
- Male
- Middle Aged
- Pandemics
- Pneumonia, Viral
- Proportional Hazards Models
- Risk Assessment
- SARS-CoV-2
- Sex Characteristics
- Smoking
- State Medicine
- Young Adult
Advanced ophthalmic nurse practitioners: the potential to improve outcomes for older people with cataracts.
Patient Satisfaction in the Spanish National Health Service: Partial Least Squares Structural Equation Modeling.
MeSH Terms
- Cross-Sectional Studies
- Gross Domestic Product
- Health Care Rationing
- Health Expenditures
- Humans
- Latent Class Analysis
- Least-Squares Analysis
- Life Expectancy
- Patient Safety
- Patient Satisfaction
- Spain
- State Medicine
Keywords
- National Health Service
- health policy
- partial least squares structural equation modeling (PLS-SEM)
- patient satisfaction
- quality of healthcare
Heart failure with preserved ejection fraction (HFpEF) pathophysiology study (IDENTIFY-HF): does increased arterial stiffness associate with HFpEF, in addition to ageing and vascular effects of comorbidities? Rationale and design.
MeSH Terms
- Aged
- Aged, 80 and over
- Aging
- Biomarkers
- Comorbidity
- Diabetes Mellitus
- Echocardiography
- Exercise Tolerance
- Female
- Heart Failure
- Heart Ventricles
- Humans
- Hypertension
- Male
- Observational Studies as Topic
- Prospective Studies
- Pulse Wave Analysis
- Research Design
- Stroke Volume
- Vascular Stiffness
Keywords
- arterial stiffness
- comorbidities
- heart failure with preserved ejection fraction
- pathophysiology
Challenges to concordance: theories that explain variations in patient responses.
Optimism is associated with exceptional longevity in 2 epidemiologic cohorts of men and women.
NKAP
NKAP Regulates Senescence and Cell Death Pathways in Hematopoietic Progenitors.
NKX6-1
The dynamic methylome of islets in health and disease.
NLRC4
Hyperglycemia-induced inflamm-aging accelerates gingival senescence via NLRC4 phosphorylation.
MeSH Terms
- Aging
- Animals
- Apoptosis Regulatory Proteins
- Blotting, Western
- Calcium-Binding Proteins
- Cellular Senescence
- Clustered Regularly Interspaced Short Palindromic Repeats
- Gingiva
- Glucose
- Hyperglycemia
- Immunohistochemistry
- Inflammation
- Interferon Regulatory Factors
- Male
- Mice
- Mice, Inbred C57BL
- RAW 264.7 Cells
- Signal Transduction
Keywords
- NLRC4
- SASP
- aging
- cellular senescence
- diabetes
- gingiva
- hyperglycemia
- inflamm-aging
- inflammasome
- inflammation
NLRP12
Persistent DNA damage-induced NLRP12 improves hematopoietic stem cell function.
NLRP3
Innate and Adaptive Immunity in Aging and Longevity: The Foundation of Resilience.
TET2-Loss-of-Function-Driven Clonal Hematopoiesis Exacerbates Experimental Insulin Resistance in Aging and Obesity.
Repeated propofol exposure-induced neuronal damage and cognitive impairment in aged rats by activation of NF-κB pathway and NLRP3 inflammasome.
A Small Molecule Stabilizer of the MYC G4-Quadruplex Induces Endoplasmic Reticulum Stress, Senescence and Pyroptosis in Multiple Myeloma.
Interleukin-1β Drives Cellular Senescence of Rat Astrocytes Induced by Oligomerized Amyloid β Peptide and Oxidative Stress.
Mechanisms of NLRP3 priming in inflammaging and age related diseases.
Lamivudine Inhibits [i]Alu[/i] RNA-induced Retinal Pigment Epithelium Degeneration via Anti-inflammatory and Anti-senescence Activities.
The NLRP3 Inflammasome: Metabolic Regulation and Contribution to Inflammaging.
Aging aggravated liver ischemia and reperfusion injury by promoting STING-mediated NLRP3 activation in macrophages.
Targeting NLRP3 Inflammasome Reduces Age-Related Experimental Alveolar Bone Loss.
Korean Red Ginseng Suppresses the Expression of Oxidative Stress Response and NLRP3 Inflammasome Genes in Aged C57BL/6 Mouse Ovaries.
Cepharanthine promotes the effect of dexmedetomidine on the deposition of β-amyloid in the old age of the senile dementia rat model by regulating inflammasome expression.
Ginsenoside Rg1 ameliorates glomerular fibrosis during kidney aging by inhibiting NOX4 and NLRP3 inflammasome activation in SAMP8 mice.
Blockade of the NLRP3 inflammasome improves metabolic health and lifespan in obese mice.
Autophagy and NLRP3 inflammasome crosstalk in neuroinflammation in aged bovine brains.
NLRP3 Inflammasome Inhibition by MCC950 in Aged Mice Improves Health via Enhanced Autophagy and PPARα Activity.
NLRP3 inflammasome suppression improves longevity and prevents cardiac aging in male mice.
Reduced NRF2 expression suppresses endothelial progenitor cell function and induces senescence during aging.
MeSH Terms
- Aging
- Animals
- Cellular Senescence
- Endothelial Progenitor Cells
- Mice
- NF-E2-Related Factor 2
- NF-kappa B
- NLR Family, Pyrin Domain-Containing 3 Protein
- Neovascularization, Physiologic
- Oxidative Stress
Keywords
- NLRP3 inflammasome
- NRF2
- aging
- endothelial progenitor cells
- oxidative stress
Effect of Aging on Taurine Transporter (TauT) Expression in the Mouse Brain Cortex.
NMI
Age-Dependent Control of Shoulder Muscles During a Reach-and-Lift Task.
NMS
Uncontrolled Diabetes as an Associated Factor with Dynapenia in Adults Aged 50 Years or Older: Sex Differences.
NMUR1
[Medicinal Chemistry Focused on Mid-sized Peptides Derived from Biomolecules].
MeSH Terms
- Aging
- Chemistry, Pharmaceutical
- Drug Discovery
- Humans
- Life Style
- Molecular Targeted Therapy
- Muscle Weakness
- Muscular Atrophy
- Myostatin
- Neuropeptides
- Obesity
- Peptides
- Receptors, Neurotransmitter
- Structure-Activity Relationship
Keywords
- myostatin inhibitor
- neuromedin U receptor-selective agonist
- peptide
NNT
Yoga, Health-Related Quality of Life and Mental Well-Being: A Re-analysis of a Meta-analysis Using the Quality Effects Model.
Statins After Myocardial Infarction in the Oldest: A Cohort Study in the Clinical Practice Research Datalink Database.
MeSH Terms
- Aged
- Aged, 80 and over
- Case-Control Studies
- Databases, Factual
- Female
- Humans
- Hydroxymethylglutaryl-CoA Reductase Inhibitors
- Male
- Myocardial Infarction
- Proportional Hazards Models
- Retrospective Studies
- Risk Assessment
- Secondary Prevention
- Stroke
Keywords
- geriatrics
- myocardial infarction
- secondary prevention
- statin
- time varying
NOP10
Pseudouridylation defect due to [i]DKC1[/i] and [i]NOP10[/i] mutations causes nephrotic syndrome with cataracts, hearing impairment, and enterocolitis.
MeSH Terms
- Animals
- Cataract
- Cell Cycle Proteins
- Child
- Enterocolitis
- Female
- Genetic Predisposition to Disease
- Hearing Loss, Sensorineural
- Humans
- Longevity
- Male
- Models, Molecular
- Molecular Dynamics Simulation
- Mutation
- Nephrotic Syndrome
- Nuclear Proteins
- Pedigree
- Protein Conformation
- RNA, Ribosomal
- Ribonucleoproteins, Small Nucleolar
- Zebrafish
Keywords
- H/ACA snoRNP
- pediatrics
- pseudouridylation
- rRNA
- telomere
NOS1
Prepubertal overexposure to manganese induce precocious puberty through GABA receptor/nitric oxide pathway in immature female rats.
MeSH Terms
- Aging
- Animals
- Chlorides
- Endocrine Disruptors
- Female
- Gonadotropin-Releasing Hormone
- Manganese Compounds
- Neurons
- Nitric Oxide
- Ovary
- Preoptic Area
- Rats
- Rats, Sprague-Dawley
- Receptors, GABA-A
- Sexual Maturation
- Signal Transduction
- Uterus
- Weaning
Keywords
- GABA(A)R
- GnRH
- Manganese
- Nitric oxide
- Precocious puberty
NOS3
Application of Oxidative Stress to a Tissue-Engineered Vascular Aging Model Induces Endothelial Cell Senescence and Activation.
NOTCH1
[How Does Aging Contribute to Cancer?]
H19 is not hypomethylated or upregulated with age or sex in the aortic valves of mice.
NOTCH4
Age-dependent autophagy induction after injury promotes axon regeneration by limiting NOTCH.
NOX4
Sestrin2 Attenuates Cellular Senescence by Inhibiting NADPH Oxidase 4 Expression.
NPM1
Flow cytometric identification and cell-line establishment of macrophages in naked mole-rats.
NPR1
The NPR1-WRKY46-WRKY6 signaling cascade mediates probenazole/salicylic acid-elicited leaf senescence in Arabidopsis thaliana.
Loss of proton/calcium exchange 1 results in the activation of plant defense and accelerated senescence in Arabidopsis.
NPW
Novel information processing at work across time is associated with cognitive change in later life: A 14-year longitudinal study.
NPY
Neuropeptide Y Enhances Progerin Clearance and Ameliorates the Senescent Phenotype of Human Hutchinson-Gilford Progeria Syndrome Cells.
Effects of rikkunshito supplementation on resistance to oxidative stress and lifespan in mice.
NRAS
Senescent cholangiocytes release extracellular vesicles that alter target cell phenotype via the epidermal growth factor receptor.
STAT3 Relays a Differential Response to Melanoma-Associated [i]NRAS[/i] Mutations.
Cooperation of Dnmt3a R878H with Nras G12D promotes leukemogenesis in knock-in mice: a pilot study.
MeSH Terms
- Animals
- Apoptosis
- Carcinogenesis
- Cell Differentiation
- DNA (Cytosine-5-)-Methyltransferases
- Disease Models, Animal
- Disease Progression
- Gene Expression Regulation, Neoplastic
- Gene Knock-In Techniques
- Leukemia, Myeloid, Acute
- Longevity
- Mice
- Mice, Inbred C57BL
- Mice, Transgenic
- Monomeric GTP-Binding Proteins
- Mutation
- Phenotype
- Pilot Projects
- Proto-Oncogene Proteins c-myc
- RNA-Seq
- Transcription, Genetic
Keywords
- Acute myeloid leukemia
- DNMT3A mutation
- Myc activation
- Nras G12D
NRL
Development of a cyclophosphamide stress test to predict resilience to aging in mice.
NRM
Association between Clonal Hematopoiesis and Late Nonrelapse Mortality after Autologous Hematopoietic Cell Transplantation.
MeSH Terms
- Adult
- Age Factors
- Aged
- Aging
- Autografts
- Female
- Hematopoiesis
- Hematopoietic Stem Cell Transplantation
- Humans
- Lymphoma, Non-Hodgkin
- Male
- Middle Aged
- Multiple Myeloma
- Retrospective Studies
Keywords
- Autologous
- Clonal hematopoiesis
- Lymphoma
- Multiple myeloma
- Nonrelapse mortality
- Survivors
- Transplantation
NSF
Effects of air pollution on children from a socioecological perspective.
MeSH Terms
- Air Pollution
- Child Mortality
- Child, Preschool
- Environment
- Humans
- Income
- Infant
- Life Expectancy
- Retrospective Studies
- Socioeconomic Factors
- Sociological Factors
Keywords
- Deaths of children under age 5
- Electrification rates
- Income
- Inequality in life expectancy
- Natural resource depletion
- Non-solid fuel
- Outdoor and indoor air pollution
- Socioecological perspective
NT5E
The NT5E gene variant strongly affects the degradation rate of inosine 5'-monophosphate under postmortem conditions in Japanese Black beef.
NTHL1
Mitochondrial base excision repair positively correlates with longevity in the liver and heart of mammals.
NUCB2
Ontogenetic Pattern Changes of Nucleobindin-2/Nesfatin-1 in the Brain and Intestinal Bulb of the Short Lived African Turquoise Killifish.
OGA
NPGPx-Mediated Adaptation to Oxidative Stress Protects Motor Neurons from Degeneration in Aging by Directly Modulating O-GlcNAcase.
OGG1
Advanced Age Is Associated with Iron Dyshomeostasis and Mitochondrial DNA Damage in Human Skeletal Muscle.
MeSH Terms
- Adult
- Aged
- Aged, 80 and over
- Aging
- DNA, Mitochondrial
- Female
- Homeostasis
- Humans
- Inflammation
- Iron
- Male
- Mitochondria, Muscle
- Quadriceps Muscle
- Young Adult
Keywords
- ZIP
- ferritin
- hepcidin
- inflammation
- iron overload
- mitochondrial dysfunction
- mtDNA
- muscle aging
- physical performance
- transferrin
OGT
ELT-2 promotes O-GlcNAc transferase OGT-1 expression to modulate Caenorhabditis elegans lifespan.
Neuronal O-GlcNAcylation Improves Cognitive Function in the Aged Mouse Brain.
OSM
Age Differences in Sexual Minority Stress and the Importance of Friendship in Later Life.
OTC
Age and growth of stocked juvenile Shoal Bass in a tailwater: Environmental variation and accuracy of daily age estimates.
P2RY12
Potential caveats of putative microglia-specific markers for assessment of age-related cerebrovascular neuroinflammation.
Microglial changes in the early aging stage in a healthy retina and an experimental glaucoma model.
Patterns of Expression of Purinergic Receptor P2RY12, a Putative Marker for Non-Activated Microglia, in Aged and Alzheimer's Disease Brains.
MeSH Terms
- Aging
- Alzheimer Disease
- Biomarkers
- Brain
- Humans
- Immunohistochemistry
- Inflammation
- Macrophages
- Microglia
- Phenotype
- Plaque, Amyloid
- Receptors, Purinergic P2Y2
Keywords
- Alzheimer’s disease
- activation phenotypes
- amyloid
- immunohistochemistry
- microglia
- neuroinflammation
- temporal cortex
P4HA2
Expanding the Phenotypic and Genotypic Landscape of Nonsyndromic High Myopia: A Cross-Sectional Study in 731 Chinese Patients.
MeSH Terms
- Adolescent
- Adult
- Aged
- Aged, 80 and over
- Aging
- Asian Continental Ancestry Group
- Axial Length, Eye
- Child
- Child, Preschool
- China
- Cross-Sectional Studies
- DNA Mutational Analysis
- Female
- Genetic Association Studies
- Genotype
- Humans
- Male
- Middle Aged
- Myopia, Degenerative
- Phenotype
- Retinal Diseases
- Vision, Low
- Young Adult
P4HA3
Age-associated genes in human mammary gland drive human breast cancer progression.
MeSH Terms
- Adult
- Age Factors
- Aged
- Aged, 80 and over
- Animals
- Biomarkers, Tumor
- Breast
- Breast Neoplasms
- Disease Progression
- Dyneins
- Female
- Gene Expression Regulation, Neoplastic
- Heterografts
- Humans
- Mice
- Mice, Inbred NOD
- Mice, SCID
- Middle Aged
- Procollagen-Proline Dioxygenase
- Prognosis
- Survival Rate
- Tumor Cells, Cultured
Keywords
- ALX4
- Aging
- Breast cancer
- DYNLT3
- Gene expression
- P4HA3
- Relapse-free survival
- Transcriptomics
- Tumor progression
PAH
Changes in light absorption by brown carbon in soot particles due to heterogeneous ozone aging in a smog chamber.
Factors associated with pulmonary arterial hypertension (PAH) in systemic sclerosis (SSc).
Potentially Avoidable Hospitalization among Long-Term Care Insurance Beneficiaries with Dementia.
PAM
Relationship between patient activation measurement and self-rated health in patients with chronic diseases.
Reversal of Age-Related Neuronal Atrophy by α5-GABAA Receptor Positive Allosteric Modulation.
The ratio of prematurely aging to non-prematurely aging mice cohabiting, conditions their behavior, immunity and lifespan.
PAX8
Inadequate control of thyroid hormones sensitizes to hepatocarcinogenesis and unhealthy aging.
PBX1
Internalization of the TAT-PBX1 fusion protein significantly enhances the proliferation of human hair follicle-derived mesenchymal stem cells and delays their senescence.
PC
Blended home-based exercise and dietary protein in community-dwelling older adults: a cluster randomized controlled trial.
Right ventricular diastolic function in aging: a head-to-head comparison between phase-contrast MRI and Doppler echocardiography.
Pulse Width and Implantable Pulse Generator Longevity in Pallidal Deep Brain Stimulation for Dystonia: A Population-Based Comparative Effectiveness Study.
Gemcitabine plus nab-paclitaxel with initial dose reduction for older patients with advanced pancreatic cancer.
Protective effects of 17-β-oestradiol and phytoestrogen on age-induced oxidative stress and inhibition of surfactant synthesis in rat type II pneumocytes.
Pacing During 200-m Competitive Masters Swimming.
Prostate cancer in Pennsylvania: The role of older age at diagnosis, aggressiveness, and environmental risk factors on treatment and mortality using data from the Pennsylvania Cancer Registry.
Extracranial versus intracranial hydro-hemodynamics during aging: a PC-MRI pilot cross-sectional study.
MeSH Terms
- Aged
- Aged, 80 and over
- Brain
- Cerebral Ventricles
- Cerebrospinal Fluid
- Cerebrovascular Circulation
- Cross-Sectional Studies
- Female
- Hemodynamics
- Humans
- Magnetic Resonance Imaging
- Male
- Middle Aged
Keywords
- Aging
- Arterial cerebral blood flow
- CSF flow
- PC-MRI
- Pulsatility
- Venous cerebral blood flow
Age-specific health-related quality of life in disease-free long-term prostate cancer survivors versus male population controls-results from a population-based study.
MeSH Terms
- Adult
- Age Factors
- Aged
- Aging
- Cancer Survivors
- Case-Control Studies
- Disease-Free Survival
- Germany
- Humans
- Male
- Middle Aged
- Prostatic Neoplasms
- Quality of Life
- Surveys and Questionnaires
- Young Adult
Keywords
- Health-related quality of life
- Long-term survivor
- Population-based
- Prostate cancer
Cross-Linked Polyphenol-Based Drug Nano-Self-Assemblies Engineered to Blockade Prostate Cancer Senescence.
MeSH Terms
- Animals
- Antineoplastic Agents
- Apoptosis
- Cell Line, Tumor
- Cellular Senescence
- Docetaxel
- Forkhead Box Protein O1
- Humans
- Male
- Mice
- Mice, Nude
- Nanostructures
- Polyphenols
- Prostatic Neoplasms
- Receptor, Transforming Growth Factor-beta Type I
- Signal Transduction
- Tannins
- Transplantation, Heterologous
Keywords
- DSAs
- apoptosis
- docetaxel
- nanoassemblies
- prostate cancer
- senescence
An Immersive Virtual Reality Platform for Assessing Spatial Navigation Memory in Predementia Screening: Feasibility and Usability Study.
PCNA
Impairment of Pol β-related DNA Base-excision Repair Leads to Ovarian Aging in Mice.
[Heat shock protein 90 (HSP90) in age-dependent changes in the number of fibroblasts in human skin.]
MeSH Terms
- Adolescent
- Adult
- Aging
- Child
- Child, Preschool
- Dermis
- Female
- Fibroblasts
- HSP90 Heat-Shock Proteins
- Humans
- Infant
- Infant, Newborn
- Middle Aged
- Pregnancy
- Young Adult
Keywords
- HSP90
- PCNA
- aging
- fibroblasts
- skin
A Higher Frequency Administration of the Nontoxic Cycloartane-Type Triterpene Argentatin A Improved Its Anti-Tumor Activity.
[Mechanosensitive protein of Hippo regulatory pathway - transcription coactivator with PZD-binding motif (TAZ) in human skin during aging.]
MeSH Terms
- Adolescent
- Adult
- Aged
- Aged, 80 and over
- Aging
- Child
- Child, Preschool
- Dermis
- Female
- Fibroblasts
- Humans
- Infant
- Infant, Newborn
- Middle Aged
- Pregnancy
- Protein-Serine-Threonine Kinases
- Skin Aging
- Trans-Activators
- Young Adult
Keywords
- CD31
- PCNA
- TAZ
- aging
- blood vessels
- fibroblasts
- skin
[Mechanosensitive Yes-associated protein in human skin during aging.]
MeSH Terms
- Adaptor Proteins, Signal Transducing
- Adult
- Aged
- Aged, 80 and over
- Aging
- Dermis
- Endothelial Cells
- Female
- Fibroblasts
- Humans
- Middle Aged
- Pregnancy
- Skin Aging
- Transcription Factors
Keywords
- CD31
- PCNA
- YAP
- aging
- blood vessels
- fibroblasts
- skin
[Role of mechanosensitive protein Piezo1 in human age-dependent changes in the number of fibroblasts and blood vessels in human skin.]
MeSH Terms
- Adolescent
- Adult
- Aged
- Aged, 80 and over
- Blood Vessels
- Child
- Child, Preschool
- Dermis
- Female
- Fibroblasts
- Humans
- Infant
- Ion Channels
- Male
- Middle Aged
- Platelet Endothelial Cell Adhesion Molecule-1
- Pregnancy
- Proliferating Cell Nuclear Antigen
- Skin Aging
Keywords
- CD31
- PCNA
- Piezo1
- aging
- blood vessels
- fibroblasts
- skin
PCSK9
Lipoprotein removal mechanisms and aging: implications for the cardiovascular health of the elderly.
The role of proprotein convertase subtilisin-kexin type 9 (PCSK9) in the vascular aging process - is there a link?
PDCD4
Petal abscission in roses is associated with the activation of a truncated version of the animal PDCD4 homologue, RbPCD1.
PDE2A
TAK-915, a phosphodiesterase 2A inhibitor, ameliorates the cognitive impairment associated with aging in rodent models.
MeSH Terms
- Aging
- Animals
- Brain
- Cognition
- Cognition Disorders
- Cognitive Dysfunction
- Cyclic AMP
- Cyclic GMP
- Cyclic Nucleotide Phosphodiesterases, Type 2
- Male
- Memory Disorders
- Memory, Episodic
- Phosphodiesterase Inhibitors
- Pyrazines
- Pyridines
- Rats
- Rats, Inbred F344
- Rats, Long-Evans
- Rats, Sprague-Dawley
Keywords
- Aging
- Cognition
- PDE2A
- TAK-915
PDE4D
Phosphodiesterase PDE4D Is Decreased in Frontal Cortex of Aged Rats and Positively Correlated With Working Memory Performance and Inversely Correlated With PKA Phosphorylation of Tau.
PDE5A
Repurposing erectile dysfunction drugs tadalafil and vardenafil to increase bone mass.
MeSH Terms
- Aging
- Animals
- Bone Density
- Bone and Bones
- Brain
- Cell Differentiation
- Cyclic Nucleotide Phosphodiesterases, Type 5
- Drug Repositioning
- Erectile Dysfunction
- Humans
- Male
- Mice
- Middle Aged
- Models, Animal
- Models, Molecular
- Neurons
- Osteoblasts
- Osteoclasts
- Osteogenesis
- Osteoporosis
- Osteoporotic Fractures
- Phosphodiesterase 5 Inhibitors
- Primary Cell Culture
- Tadalafil
- Vardenafil Dihydrochloride
Keywords
- PDE5 inhibitor
- computational modeling
- cyclic GMP
- osteoporosis
- resorption
PDK1
Inhibition of 3-phosphoinositide-dependent protein kinase 1 (PDK1) can revert cellular senescence in human dermal fibroblasts.
The Impact of the PI3K/Akt Signaling Pathway in Anxiety and Working Memory in Young and Middle-Aged PDK1 K465E Knock-In Mice.
PER1
Quercetin, caffeic acid and resveratrol regulate circadian clock genes and aging-related genes in young and old human lung fibroblast cells.
MeSH Terms
- ARNTL Transcription Factors
- Age Factors
- Aging
- CLOCK Proteins
- Caffeic Acids
- Cell Line
- Circadian Clocks
- Circadian Rhythm
- Fibroblasts
- Humans
- NF-E2-Related Factor 2
- Polyphenols
- Quercetin
- Receptors, Glucocorticoid
- Resveratrol
- Sirtuin 1
Keywords
- Caffeic acid
- Circadian clock genes
- NR1D1
- NRF2
- Quercetin
- Resveratrol
PER2
NAD Controls Circadian Reprogramming through PER2 Nuclear Translocation to Counter Aging.
MeSH Terms
- ARNTL Transcription Factors
- Age Factors
- Aging
- Animals
- CLOCK Proteins
- Circadian Clocks
- Circadian Rhythm
- Cytokines
- Female
- HEK293 Cells
- Humans
- Male
- Mice
- Mice, Inbred C57BL
- NAD
- Period Circadian Proteins
- Sirtuin 1
- Sirtuins
Keywords
- NAD(+)
- SIRT1
- aging
- circadian
- clock
- heat shock factor 1
- liver
- nicotinamide mononucleotide
- nicotinamide riboside
- transcriptomics
PEX19
A genome-wide screen identifies genes that suppress the accumulation of spontaneous mutations in young and aged yeast cells.
MeSH Terms
- Amino Acid Transport Systems, Basic
- Cellular Senescence
- DNA Replication
- Flap Endonucleases
- Gene Ontology
- Genetic Techniques
- Genomic Instability
- Membrane Proteins
- Mutagenesis
- Mutation
- Mutation Accumulation
- Mutation Rate
- Nuclear Pore Complex Proteins
- Saccharomyces cerevisiae
- Saccharomyces cerevisiae Proteins
- Single-Strand Specific DNA and RNA Endonucleases
Keywords
- genome stability
- high-throughput screen
- mutagenesis
- mutation rate
- replicative aging
- yeast
PEX5
Aging lowers PEX5 levels in cortical neurons in male and female mouse brains.
PFAS
Associations between serum concentrations of perfluoroalkyl substances and DNA methylation in women exposed through drinking water: A pilot study in Ronneby, Sweden.
Perfluorinated alkyl substances impede growth, reproduction, lipid metabolism and lifespan in Daphnia magna.
The effect of weathering on per- and polyfluoroalkyl substances (PFASs) from durable water repellent (DWR) clothing.
MeSH Terms
- Acrylates
- Alcohols
- Clothing
- Environmental Monitoring
- Fluorocarbon Polymers
- Fluorocarbons
- Humidity
- Models, Chemical
- Textiles
- Water
- Water Pollutants, Chemical
- Weather
Keywords
- Aging
- Durable water repellency
- Outdoor clothing
- Per- and polyfluoroalkyl substances
- Textile
- Weathering
PGC
The Aging Stress Response and Its Implication for AMD Pathogenesis.
Constitutive PGC-1α Overexpression in Skeletal Muscle Does Not Contribute to Exercise-Induced Neurogenesis.
Dysregulated Autophagy Mediates Sarcopenic Obesity and Its Complications via AMPK and PGC1α Signaling Pathways: Potential Involvement of Gut Dysbiosis as a Pathological Link.
Resemblance and differences in dietary restriction nephroprotective mechanisms in young and old rats.
Acute and chronic effects of resistance training on skeletal muscle markers of mitochondrial remodeling in older adults.
PGC-1α-mediated regulation of mitochondrial function and physiological implications.
Targeting Mitochondrial Network Architecture in Down Syndrome and Aging.
Colchicine treatment impairs skeletal muscle mitochondrial function and insulin sensitivity in an age-specific manner.
A novel dipeptide from potato protein hydrolysate augments the effects of exercise training against high-fat diet-induced damages in senescence-accelerated mouse-prone 8 by boosting pAMPK / SIRT1/ PGC-1α/ pFOXO3 pathway.
Mitochondrial nucleoid remodeling and biogenesis are regulated by the p53-p21 -PKCζ pathway in p16 -silenced cells.
[Metabolic Alteration in Aging Process: Metabolic Remodeling in White Adipose Tissue by Caloric Restriction].
MeSH Terms
- Adipose Tissue, White
- Aging
- Animals
- Caloric Restriction
- Gene Expression
- Humans
- Longevity
- Mice
- Organelle Biogenesis
- Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha
- Sirtuin 3
- Sterol Regulatory Element Binding Protein 1
- Up-Regulation
Keywords
- caloric restriction (CR)
- fatty acid biosynthesis
- mitochondria
- white adipose tissue (WAT)
Kynurenine aminotransferase isoforms display fiber-type specific expression in young and old human skeletal muscle.
Ubiquinol-10 delays postovulatory oocyte aging by improving mitochondrial renewal in pigs.
Mitochondrial oxidative capacity and NAD biosynthesis are reduced in human sarcopenia across ethnicities.
MicroRNA-34a (miR-34a) Mediates Retinal Endothelial Cell Premature Senescence through Mitochondrial Dysfunction and Loss of Antioxidant Activities.
Constitutive PGC-1α overexpression in skeletal muscle does not protect from age-dependent decline in neurogenesis.
PGK2
Arsenic influences spermatogenesis by disorganizing the elongation of spermatids in adult male mice.
PGLS
547 transcriptomes from 44 brain areas reveal features of the aging brain in non-human primates.
PIEZO1
Niche stiffness underlies the ageing of central nervous system progenitor cells.
PINK1
Spermidine inhibits neurodegeneration and delays aging via the PINK1-PDR1-dependent mitophagy pathway in [i]C. elegans[/i].
Female mice are resilient to age-related decline of substantia nigra dopamine neuron firing parameters.
Attenuation of epigenetic regulator SMARCA4 and ERK-ETS signaling suppresses aging-related dopaminergic degeneration.
SIRT1 alleviates high-magnitude compression-induced senescence in nucleus pulposus cells via PINK1-dependent mitophagy.
Synergistic action of propolis with levodopa in the management of Parkinsonism in Drosophila melanogaster.
Compression-induced senescence of nucleus pulposus cells by promoting mitophagy activation via the PINK1/PARKIN pathway.
Doxorubicin-induced normal breast epithelial cellular aging and its related breast cancer growth through mitochondrial autophagy and oxidative stress mitigated by ginsenoside Rh2.
Mitochondrial DNA heteroplasmy rises in substantial nigra of aged PINK1 KO mice.
PIP
Potentially inappropriate prescriptions according to explicit and implicit criteria in patients with multimorbidity and polypharmacy. MULTIPAP: A cross-sectional study.
Quality of prescribing predicts hospitalisation in octogenarians: life and living in advanced age: a cohort study in New Zealand (LiLACS NZ).
MeSH Terms
- Aged
- Aged, 80 and over
- Aging
- Cohort Studies
- Drug Prescriptions
- Female
- Follow-Up Studies
- Forecasting
- Hospitalization
- Humans
- Inappropriate Prescribing
- Longitudinal Studies
- Male
- New Zealand
- Patient Discharge
- Potentially Inappropriate Medication List
Keywords
- Appropriate prescribing
- Ethnicity
- Longitudinal study
- Older people
PLIN2
Cardiac overexpression of perilipin 2 induces atrial steatosis, connexin 43 remodeling, and atrial fibrillation in aged mice.
MeSH Terms
- Animals
- Atrial Fibrillation
- Connexin 43
- Gene Knock-In Techniques
- Heart Atria
- Isolated Heart Preparation
- Lipid Droplets
- Mice
- Mice, Transgenic
- Microscopy, Electron
- Myocytes, Cardiac
- Perilipin-2
- Sterol Esterase
- Triglycerides
- Voltage-Sensitive Dye Imaging
Keywords
- aging
- cardiac steatosis
- gap junction
- lipid droplets
- lipotoxic arrhythmia
PLK4
A novel lncRNA PLK4 up-regulated by talazoparib represses hepatocellular carcinoma progression by promoting YAP-mediated cell senescence.
Differential expression of AURKA/PLK4 in quiescence and senescence of osteosarcoma U2OS cells.
PLN
An analysis of the costs of treating aged patients in a large clinical hospital in Poland under the pressure of recent demographic trends.
PML
Progressive multifocal leukoencephalopathy in dimethyl fumarate-treated multiple sclerosis patients.
PML2-mediated thread-like nuclear bodies mark late senescence in Hutchinson-Gilford progeria syndrome.
PNN
Hyaluronan degradation and release of a hyaluronan-aggrecan complex from perineuronal nets in the aged mouse brain.
PNP
Temporal Discrimination Thresholds and Proprioceptive Performance: Impact of Age and Nerve Conduction.
POLL
Temporal trends in loss of life expectancy after a cancer diagnosis among the Australian population.
POLR3A
Nucleolar disruption, activation of P53 and premature senescence in POLR3A-mutated Wiedemann-Rautenstrauch syndrome fibroblasts.
POMC
Gpr17 deficiency in POMC neurons ameliorates the metabolic derangements caused by long-term high-fat diet feeding.
POR
The Ventricular System Enlarges Abnormally in the Seventies, Earlier in Men, and First in the Frontal Horn: A Study Based on More Than 3,000 Scans.
POT1
MiR-185 targets POT1 to induce telomere dysfunction and cellular senescence.
Seryl tRNA synthetase cooperates with POT1 to regulate telomere length and cellular senescence.
POU5F1
Cell quality evaluation with gene expression analysis of spheroids (3D) and adherent (2D) adipose stem cells.
PPID
Relationships of inflamm-aging with circulating nutrient levels, body composition, age, and pituitary pars intermedia dysfunction in a senior horse population.
PRDM8
PRDM8 reveals aberrant DNA methylation in aging syndromes and is relevant for hematopoietic and neuronal differentiation.
PRDX1
Active vitamin D supplementation alleviates initiation and progression of nonalcoholic fatty liver disease by repressing the p53 pathway.
MeSH Terms
- Animals
- Apoptosis
- Cellular Senescence
- Diet, High-Fat
- Dietary Supplements
- Fas Ligand Protein
- Hepatocytes
- Metabolic Networks and Pathways
- Mice, Knockout
- Non-alcoholic Fatty Liver Disease
- Oxidative Stress
- Proteins
- Steroid Hydroxylases
- Tumor Suppressor Protein p53
- Vitamin D
- fas Receptor
Keywords
- Active vitamin D
- Apoptosis
- Nonalcoholic fatty liver disease
- Oxidative stress
- Senescence
- p53 pathway
PRDX3
Proteomic analyses reveal that ginsenoside Rg3([i]S[/i]) partially reverses cellular senescence in human dermal fibroblasts by inducing peroxiredoxin.
PRDX6
Dentate Gyrus Peroxiredoxin 6 Levels Discriminate Aged Unimpaired From Impaired Rats in a Spatial Memory Task.
PRKDC
DNA-PKcs modulates progenitor cell proliferation and fibroblast senescence in idiopathic pulmonary fibrosis.
MeSH Terms
- Animals
- Cell Line
- Cell Proliferation
- Cellular Senescence
- Chromones
- DNA Damage
- DNA Repair
- DNA-Activated Protein Kinase
- DNA-Binding Proteins
- Female
- Fibroblasts
- Humans
- Idiopathic Pulmonary Fibrosis
- Lung
- Mesenchymal Stem Cells
- Mice
- Mice, SCID
- Morpholines
Keywords
- DNA-PKcs
- IPF
- Mesenchymal progenitor cells
- Senescence
PRL
Mechanism of PRL2 phosphatase-mediated PTEN degradation and tumorigenesis.
MeSH Terms
- Animals
- Carcinogenesis
- Female
- HEK293 Cells
- Humans
- Immediate-Early Proteins
- Longevity
- Male
- Mice, Inbred C57BL
- Mice, Knockout
- Nedd4 Ubiquitin Protein Ligases
- PTEN Phosphohydrolase
- Protein Tyrosine Phosphatases
- Proto-Oncogene Proteins c-akt
- Ubiquitination
Keywords
- NEDD4
- PRL2
- PTEN
- protein tyrosine phosphatases
- ubiquitination
Prolactin mitigates deficiencies of retinal function associated with aging.
A Spontaneous Aggressive ERα+ Mammary Tumor Model Is Driven by Kras Activation.
MeSH Terms
- Aging
- Animals
- Carcinogenesis
- Datasets as Topic
- Estrogen Receptor alpha
- Female
- Gene Expression Profiling
- Humans
- Mammary Neoplasms, Experimental
- Mice
- Prolactin
- Proto-Oncogene Proteins p21(ras)
- Rats
- Signal Transduction
- Transgenes
Keywords
- ER+ breast cancer
- Ras mutations
- breast cancer
- genomic analyses
- mouse models
- prolactin
PRNP
Spontaneous generation of prions and transmissible PrP amyloid in a humanised transgenic mouse model of A117V GSS.
PROC
Does midlife aging impact women's sleep duration, continuity, and timing?: A longitudinal analysis from the Study of Women's Health Across the Nation.
PSD
Quantitative Immunoblotting Analyses Reveal that the Abundance of Actin, Tubulin, Synaptophysin and EEA1 Proteins is Altered in the Brains of Aged Mice.
Exercise Attenuates Brain Aging by Rescuing Down-Regulated Wnt/β-Catenin Signaling in Aged Rats.
Concurrent nicotine exposure to prenatal alcohol consumption alters the hippocampal and cortical neurotoxicity.
PSEN2
Accelerated brain aging towards transcriptional inversion in a zebrafish model of the K115fs mutation of human PSEN2.
MeSH Terms
- Aging
- Alternative Splicing
- Alzheimer Disease
- Animals
- Animals, Genetically Modified
- Brain
- Datasets as Topic
- Disease Models, Animal
- Down-Regulation
- Female
- Frameshift Mutation
- Gene Editing
- Gene Regulatory Networks
- Heterozygote
- Humans
- Microglia
- Presenilin-1
- Presenilin-2
- Protein Isoforms
- Proteomics
- RNA-Seq
- Up-Regulation
- Zebrafish
- Zebrafish Proteins
Loss of presenilin 2 age-dependently alters susceptibility to acute seizures and kindling acquisition.
PSMD11
The effect and mechanism of 19S proteasome PSMD11/Rpn6 subunit in D-Galactose induced mimetic aging models.
PSMD14
Upregulation of deubiquitinase PSMD14 in lung adenocarcinoma (LUAD) and its prognostic significance.
PTEN
Senescence Reprogramming by TIMP1 Deficiency Promotes Prostate Cancer Metastasis.
Alterations in Mitochondrial Dynamic-related Genes in the Peripheral Blood of Alzheimer's Disease Patients.
Human ESC-sEVs alleviate age-related bone loss by rejuvenating senescent bone marrow-derived mesenchymal stem cells.
The precursor of PI(3,4,5)P alleviates aging by activating daf-18(Pten) and independent of daf-16.
MeSH Terms
- Aging
- Animals
- Animals, Genetically Modified
- Caenorhabditis elegans
- Caenorhabditis elegans Proteins
- Cell Line, Tumor
- Female
- Forkhead Transcription Factors
- Inositol
- Locomotion
- Longevity
- Metabolic Networks and Pathways
- Metabolomics
- Mice
- Mitophagy
- Models, Animal
- PTEN Phosphohydrolase
- Phosphatidylinositol Phosphates
- Protein Kinases
- Protein-Serine-Threonine Kinases
- RNA Interference
- RNA-Seq
Quercetin alleviates kidney fibrosis by reducing renal tubular epithelial cell senescence through the SIRT1/PINK1/mitophagy axis.
Downregulation of PTEN mediates bleomycin-induced premature senescence in lung cancer cells by suppressing autophagy.
miR-155 inhibits mitophagy through suppression of BAG5, a partner protein of PINK1.
Environmental Exposures and Asthma Development: Autophagy, Mitophagy, and Cellular Senescence.
PTEN loss regulates alveolar epithelial cell senescence in pulmonary fibrosis depending on Akt activation.
MeSH Terms
- Aging
- Cellular Senescence
- Epithelial Cells
- Humans
- Idiopathic Pulmonary Fibrosis
- PTEN Phosphohydrolase
- Proto-Oncogene Proteins c-akt
- Pulmonary Alveoli
- Respiratory Mucosa
Keywords
- aging
- cellular senescence
- phosphatase and tension homolog deleted on chromosome ten
- protein kinase B
- pulmonary fibrosis
PTH
Vitamin D Receptor Polymorphisms in Sex-Frailty Paradox.
Parathyroid hormone ameliorates temporomandibular joint osteoarthritic-like changes related to age.
MeSH Terms
- Aging
- Animals
- Calcium-Regulating Hormones and Agents
- Cells, Cultured
- Disease Models, Animal
- Male
- Mice
- Mice, Inbred C57BL
- Osteoarthritis
- Osteogenesis
- Parathyroid Hormone
- Temporomandibular Joint
Keywords
- cellular senescence
- cyclin-dependent kinase inhibitor P16INK4A
- marrow mesenchymal stem cells
- osteoarthritis
- temporomandibular joint disorders
PTP4A3
Transcriptional and Functional Changes of the Human Microvasculature during Physiological Aging and Alzheimer Disease.
PTPN11
Fine mapping genetic variants associated with age at puberty and sow fertility using SowPro90 genotyping array.
PTTG1
[Down-regulated PTTG1 expression promotes the senescence of human prostate cancer LNCaP-AI].
MeSH Terms
- Cell Line, Tumor
- Cell Proliferation
- Humans
- Male
- Prostatic Neoplasms, Castration-Resistant
- RNA, Small Interfering
- Securin
- beta-Galactosidase
Keywords
- LNCaP-AI cell
- castration-resistant prostate cancer
- cellular senescence
- pituitary tumor-transforming gene-1
- prostate cancer
PTX3
Aerobic Training Down-Regulates Pentraxin 3 and Pentraxin 3/Toll-Like Receptor 4 Ratio, Irrespective of Oxidative Stress Response, in Elderly Subjects.
Sex Differences in the Association Between Pentraxin 3 and Cognitive Decline: The Cardiovascular Health Study.
PUM1
Identification of reference genes for RT-qPCR data normalisation in aging studies.
RACK1
Invariable stoichiometry of ribosomal proteins in mouse brain tissues with aging.
RAF1
Circular [i]ANRIL[/i] isoforms switch from repressors to activators of [i]p15/CDKN2B[/i] expression during RAF1 oncogene-induced senescence.
RAG1
T cell senescence accelerates Angiotensin II-induced target organ damage.
RAG2
Phosphate Transporter Profiles in Murine and Human Thymi Identify Thymocytes at Distinct Stages of Differentiation.
RAN
Rapid automatized naming (RAN): effects of aging on a predictor of reading skill.
RELB
New control of the senescence barrier in breast cancer.
REST
[Brain and Neuronal Aging: Aged Brain Controls via Gene Expression Fidelity and Master Regulatory Factors].
Effect of 9 - PAHSA on cognitive dysfunction in diabetic mice and its possible mechanism.
MeSH Terms
- Aging
- Animals
- Behavior, Animal
- Blood Glucose
- Body Weight
- Brain
- Brain-Derived Neurotrophic Factor
- Cognitive Dysfunction
- Diabetes Mellitus, Experimental
- Exploratory Behavior
- Male
- Memory Disorders
- Mice
- Palmitic Acid
- Repressor Proteins
- Social Behavior
- Spatial Memory
- Stearic Acids
Keywords
- 9-PAHSA
- BDNF
- Diabetes mellitus
- REST
Increased REST to Optimize Life Span?
RET
Effects of resistance exercise training on redox homeostasis in older adults. A systematic review and meta-analysis.
Effects of an 8-week resistance training intervention on plantar flexor muscle quality and functional capacity in older women: A randomised controlled trial.
Resistance exercise training promotes fiber type-specific myonuclear adaptations in older adults.
Low skeletal muscle capillarization limits muscle adaptation to resistance exercise training in older adults.
MeSH Terms
- Adaptation, Physiological
- Aged
- Capillaries
- Citrate (si)-Synthase
- Exercise
- Female
- Humans
- Hypertrophy
- Male
- Muscle Fibers, Skeletal
- Muscle Proteins
- Muscle, Skeletal
- Resistance Training
- Sarcopenia
- Ubiquitin-Protein Ligases
Keywords
- Aging
- Capillary
- Fiber cross-sectional area
- Muscle hypertrophy
- Muscle protein synthesis
REV1
REV1 inhibitor JH-RE-06 enhances tumor cell response to chemotherapy by triggering senescence hallmarks.
RHEB
The Rheb-TORC1 signaling axis functions as a developmental checkpoint.
MeSH Terms
- Animals
- Animals, Genetically Modified
- Autophagy
- CRISPR-Cas Systems
- Caenorhabditis elegans
- Caenorhabditis elegans Proteins
- Life Cycle Stages
- Longevity
- Mechanistic Target of Rapamycin Complex 1
- Phosphotransferases (Alcohol Group Acceptor)
- RNA Interference
- RNA, Small Interfering
- Ras Homolog Enriched in Brain Protein
- Signal Transduction
Keywords
- MTOR
- MTORC1
- Ral
- RalGAP
- TSC
- Tuberous sclerosis complex
RHO
Conditional reprogramming: next generation cell culture.
Keywords
- 3T3-J2 fibroblast
- AACR, American Association for Cancer Research
- ACC, adenoid cystic carcinoma
- AR, androgen receptor
- CFTR, cystic fibrosis transmembrane conductance regulators
- CR, conditional reprogramming
- CYPs, cytochrome P450 enzymes
- Conditional reprogramming
- DCIS, ductal carcinoma in situ
- ECM, extracellular matrix
- ESC, embryonic stem cell
- HCMI, human cancer model initiatives
- HGF, hepatocyte growth factor
- HNE, human nasal epithelial
- HPV, human papillomaviruses
- ICD, intracellular domain
- LECs, limbal epithelial cells
- NCI, National Cancer Institute
- NGFR, nerve growth factor receptor
- NSCLC, non-small cell lung cancer
- NSG, NOD/SCID/gamma
- PDAC, pancreatic ductal adenocarcinoma
- PDX, patient derived xenograft
- PP2A, protein phosphatase 2A
- RB, retinoblastoma-associated protein
- ROCK
- ROCK, Rho kinase
- SV40, simian virus 40 large tumor antigen
- Senescence
- UVB, ultraviolet radiation b
- Y-27632
- dECM, decellularized extracellular matrix
- hASC, human adipose stem cells
- hTERT, human telomerase reverse transcriptase
- iPSCs, induction of pluripotent stem cells
- ΔNP63α, N-terminal truncated form of P63α
SARS-CoV-2 receptor ACE2 and TMPRSS2 are primarily expressed in bronchial transient secretory cells.
MeSH Terms
- Adult
- Aging
- Angiotensin-Converting Enzyme 2
- Bronchi
- COVID-19
- Cells, Cultured
- Chronic Disease
- Coronavirus Infections
- Epithelial Cells
- Female
- Gene Expression
- Gene Expression Profiling
- Germany
- Goblet Cells
- Humans
- Lung
- Male
- Middle Aged
- Pandemics
- Peptidyl-Dipeptidase A
- Pneumonia, Viral
- Reference Standards
- Sequence Analysis, RNA
- Serine Endopeptidases
- Sex Characteristics
- Single-Cell Analysis
- Smoking
- Tissue Banks
Keywords
FURIN
- COVID-19
- Human Cell Atlas
- epithelial differentiation
- respiratory tract
RICTOR
Endothelial senescence-associated secretory phenotype (SASP) is regulated by Makorin-1 ubiquitin E3 ligase.
MeSH Terms
- Cellular Senescence
- Endothelial Cells
- Human Umbilical Vein Endothelial Cells
- Humans
- MicroRNAs
- Nerve Tissue Proteins
- Phosphorylation
- Protein Binding
- Rapamycin-Insensitive Companion of mTOR Protein
- Ribonucleoproteins
- Telomeric Repeat Binding Protein 2
- Ubiquitin-Protein Ligases
Keywords
- Inflammation
- MKRN1
- Senescence
- Senescence-associated secretory phenotype (SASP)
- Telomeric repeat binding factor 2-interacting protein (TERF2IP)
- p90RSK
RIF1
53BP1 Enforces Distinct Pre- and Post-resection Blocks on Homologous Recombination.
MeSH Terms
- Aging
- Animals
- BRCA1 Protein
- DNA Breaks, Double-Stranded
- DNA Damage
- Genomic Instability
- Homologous Recombination
- Mice
- Mutation
- Poly(ADP-ribose) Polymerase Inhibitors
- Rad51 Recombinase
- Tumor Suppressor p53-Binding Protein 1
- Ubiquitin-Protein Ligases
Keywords
- 53BP1
- BRCA1
- PARPi
- aging
- cancer
- homologous recombination
- resection
- shieldin
RIPK1
Casein kinase 1G2 suppresses necroptosis-promoted testis aging by inhibiting receptor-interacting kinase 3.
Crucial role of the terminal complement complex in chondrocyte death and hypertrophy after cartilage trauma.
RIPK3
Metformin mediates cardioprotection against aging-induced ischemic necroptosis.
MeSH Terms
- Aging
- Animals
- Autophagy
- GTPase-Activating Proteins
- Humans
- Hypoglycemic Agents
- Imidazoles
- Indoles
- Male
- Metformin
- Mice
- Mice, Inbred C57BL
- Mice, Knockout
- Myocardium
- Myocytes, Cardiac
- Necroptosis
- Protein Binding
- RNA, Small Interfering
- Receptor-Interacting Protein Serine-Threonine Kinases
- Reperfusion Injury
- Sequestosome-1 Protein
Keywords
- aging
- autophagy defect
- cardioprotection
- ischemia/reperfusion injury
- metformin
- myocardial necroptosis
RNF10
Reduced RING finger protein 10 expression in macrophages is associated with aging-related inflammation.
RNF13
The effects of environmental stressors on candidate aging associated genes.
ROCK2
Physical exercise increases ROCK activity in the skeletal muscle of middle-aged rats.
RPE
Transcriptomic Profiling of Human Pluripotent Stem Cell-derived Retinal Pigment Epithelium over Time.
Relationship between Oxygen Uptake, Heart Rate, and Perceived Effort in an Aquatic Incremental Test in Older Women.
Photoreceptor Degeneration in Homozygous Male Per2 Mice During Aging.
An In-Vitro Cell Model of Intracellular Protein Aggregation Provides Insights into RPE Stress Associated with Retinopathy.
Short-Term Effect of Self-Selected Training Intensity on Ambulatory Blood Pressure in Hypertensive Older Women: A Randomized Controlled Trial.
Correlation between brain volume and retinal photoreceptor outer segment volume in normal aging and neurodegenerative diseases.
Oxidative stress in the retina and retinal pigment epithelium (RPE): Role of aging, and DJ-1.
Direct-Coupled Electroretinogram (DC-ERG) for Recording the Light-Evoked Electrical Responses of the Mouse Retinal Pigment Epithelium.
High-density lipoproteins are a potential therapeutic target for age-related macular degeneration.
MTOR-initiated metabolic switch and degeneration in the retinal pigment epithelium.
[i]Lactobacillus paracasei[/i] KW3110 Suppresses Inflammatory Stress-Induced Premature Cellular Senescence of Human Retinal Pigment Epithelium Cells and Reduces Ocular Disorders in Healthy Humans.
Retinal pigment epithelium transcriptome analysis in chronic smoking reveals a suppressed innate immune response and activation of differentiation pathways.
Differences in Intraretinal Pigment Migration Across Inherited Retinal Dystrophies.
Exosomal MiRNA Transfer between Retinal Microglia and RPE.
Functionally validated imaging endpoints in the Alabama study on early age-related macular degeneration 2 (ALSTAR2): design and methods.
Mechanisms of mitochondrial dysfunction and their impact on age-related macular degeneration.
CSF1R blockade induces macrophage ablation and results in mouse choroidal vascular atrophy and RPE disorganization.
Extracellular microparticles exacerbate oxidative damage to retinal pigment epithelial cells.
Water-based continuous and interval training in older women: Cardiorespiratory and neuromuscular outcomes (WATER study).
Retrieval Practice Improves Recollection-Based Memory Over a Seven-Day Period in Younger and Older Adults.
A Comparison of Heart Rate Training Load and Perceptual Effort Between Masters and Young Cyclists
Retinal Pigment Epithelial Cells: The Unveiled Component in the Etiology of Prpf Splicing Factor-Associated Retinitis Pigmentosa.
MeSH Terms
- Animals
- Circadian Rhythm
- Epithelial Cells
- Eye Proteins
- Humans
- Mice
- Phagocytosis
- Photoreceptor Cells, Vertebrate
- RNA Splicing Factors
- Retinal Pigment Epithelium
- Retinitis Pigmentosa
Keywords
- Aging
- Cellular stress
- Circadian rhythm
- Metabolism
- PRPF
- Phagocytosis
- Retinal pigment epithelium
- Retinitis pigmentosa
- Splicing factors
AMPK May Play an Important Role in the Retinal Metabolic Ecosystem.
MeSH Terms
- AMP-Activated Protein Kinases
- Animals
- DNA Damage
- DNA, Mitochondrial
- Disease Models, Animal
- Gene Dosage
- Metformin
- Mice
- Oxidative Stress
- Retina
- Retinal Degeneration
- Retinitis Pigmentosa
Keywords
- AMPK
- Adenosine monophosphate-activated protein kinase
- Aging
- Glycolysis
- Metabolism
- Neuroprotection
- Retina
Stem cell-derived retinal pigment epithelium from patients with age-related macular degeneration exhibit reduced metabolism and matrix interactions.
Elovanoids counteract oligomeric β-amyloid-induced gene expression and protect photoreceptors.
MeSH Terms
- Amyloid beta-Peptides
- Animals
- Apoptosis
- Autophagy
- Cells, Cultured
- Docosahexaenoic Acids
- Extracellular Matrix
- Fatty Acids, Omega-3
- Gene Expression Regulation
- Humans
- Male
- Mice, Inbred C57BL
- Mice, Transgenic
- Photoreceptor Cells
- Retina
- Retinal Pigment Epithelium
- Young Adult
Keywords
- SASP
- age-related macular degeneration
- p16
- retinal pigment epithelial cells
- senescence gene program
Genetic LAMP2 deficiency accelerates the age-associated formation of basal laminar deposits in the retina.
Age, lipofuscin and melanin oxidation affect fundus near-infrared autofluorescence.
MeSH Terms
- Age Factors
- Animals
- Biomarkers
- Choroid
- Disease Models, Animal
- Female
- Fluorescein Angiography
- Fundus Oculi
- Humans
- Lipofuscin
- Macular Degeneration
- Male
- Melanins
- Melanosomes
- Mice
- Mice, Knockout
- Optical Imaging
- Oxidation-Reduction
- Oxidative Stress
- Protein Transport
- Retinal Pigment Epithelium
- Tomography, Optical Coherence
Keywords
- Aging
- Lipofuscin
- Melanin
- Melanolipofuscin
- Oxidative stress
Relevance of working memory for reinforcement learning in older adults varies with timescale of learning.
Expression and Function of Mas-Related G Protein-Coupled Receptor D and Its Ligand Alamandine in Retina.
MeSH Terms
- Aging
- Angiotensin II
- Animals
- Cells, Cultured
- Electroretinography
- Humans
- Ligands
- Lipopolysaccharides
- Mice, Inbred C57BL
- Mice, Knockout
- Oligopeptides
- Rats
- Reactive Oxygen Species
- Receptors, G-Protein-Coupled
- Retina
Keywords
- Alamandine
- Angiotensin-(1–7)
- Mas-related G protein-coupled receptor D
- Rennin-angiotensin system
- Retina
RPIA
Suppression of p16 Induces mTORC1-Mediated Nucleotide Metabolic Reprogramming.
MeSH Terms
- Aldose-Ketose Isomerases
- Animals
- Cell Line
- Cellular Senescence
- Cyclin-Dependent Kinase Inhibitor p16
- Gene Knockdown Techniques
- Humans
- Male
- Mechanistic Target of Rapamycin Complex 1
- Mice, SCID
- Nucleotides
- Pentose Phosphate Pathway
- Protein Biosynthesis
Keywords
- BRAF
- cancer metabolism
- cell cycle
- melanoma
- nevi
- pancreatic cancer
- pentose phosphate pathway
- ribonucleotide reductase M2
- ribose-5-phosphate isomerase A
- senescence
RPS19BP1
Material basis, effect, and mechanism of ethanol extract of Pinellia ternata tubers on oxidative stress-induced cell senescence.
RTEL1
Telomere length and aging-related outcomes in humans: A Mendelian randomization study in 261,000 older participants.
RXFP3
The RXFP3 receptor is functionally associated with cellular responses to oxidative stress and DNA damage.
MeSH Terms
- Camptothecin
- Computational Biology
- DNA Damage
- Felodipine
- GTPase-Activating Proteins
- Gene Expression Regulation
- Gene Regulatory Networks
- HEK293 Cells
- Humans
- Oxidative Stress
- RNA, Messenger
- Receptors, G-Protein-Coupled
- Topoisomerase I Inhibitors
Keywords
- DNA damage
- GPCR
- aging
- relaxin 3
- relaxin family peptide 3 receptor
S100A4
Protective role of mesenchymal stem cells and mesenchymal stem cell-derived exosomes in cigarette smoke-induced mitochondrial dysfunction in mice.
S100A9
Cigarette smoke induction of S100A9 contributes to chronic obstructive pulmonary disease.
Modulation of KDM1A with vafidemstat rescues memory deficit and behavioral alterations.
MeSH Terms
- Aging
- Alzheimer Disease
- Animals
- Behavior, Animal
- Brain
- Disease Models, Animal
- Enzyme Inhibitors
- Epigenesis, Genetic
- Female
- Gene Expression
- Hippocampus
- Histone Demethylases
- Humans
- Male
- Memory Disorders
- Mice
- Mice, Inbred C57BL
- Mice, Mutant Strains
- Monoamine Oxidase Inhibitors
- Oxadiazoles
- Rats
- Rats, Sprague-Dawley
Cellular senescence induced by S100A9 in mesenchymal stromal cells through NLRP3 inflammasome activation.
MeSH Terms
- Adolescent
- Adult
- Aged
- Aged, 80 and over
- Calgranulin B
- Case-Control Studies
- Cell Line
- Cells, Cultured
- Cellular Reprogramming
- Cellular Senescence
- Female
- Humans
- Inflammasomes
- Interleukin-1beta
- Male
- Mesenchymal Stem Cells
- Middle Aged
- Myelodysplastic Syndromes
- NLR Family, Pyrin Domain-Containing 3 Protein
- Reactive Oxygen Species
- Signal Transduction
- Stem Cell Niche
- Toll-Like Receptor 4
- Up-Regulation
- Young Adult
Keywords
- NLRP3
- S100A9
- cellular senescence
- mesenchymal stromal cells
- myelodysplastic syndromes
S100A9 extends lifespan in insulin deficiency.
S100B
Aging protects rat cortical slices against to oxygen-glucose deprivation induced damage.
S1PR1
Aging Suppresses Sphingosine-1-Phosphate Chaperone ApoM in Circulation Resulting in Maladaptive Organ Repair.
SAG
WRKY42 transcription factor positively regulates leaf senescence through modulating SA and ROS synthesis in Arabidopsis thaliana.
Neurogenesis in the inner ear: the zebrafish statoacoustic ganglion provides new neurons from a Neurod/Nestin-positive progenitor pool well into adulthood.
MeSH Terms
- Adult Stem Cells
- Aging
- Animals
- Animals, Genetically Modified
- Basic Helix-Loop-Helix Transcription Factors
- Cell Differentiation
- Ear, Inner
- Embryo, Nonmammalian
- Ganglia, Sensory
- Gene Expression Regulation, Developmental
- Hair Cells, Auditory
- Larva
- Nerve Tissue Proteins
- Nestin
- Neural Stem Cells
- Neurogenesis
- Sensory Receptor Cells
- Stem Cell Niche
- Zebrafish
Keywords
- Inner ear
- Neuronal stem cells
- PNS
- Zebrafish
SAT1
Triethylenetetramine (trientine): a caloric restriction mimetic with a new mode of action.
SATB1
Loss of SATB1 Induces p21-Dependent Cellular Senescence in Post-mitotic Dopaminergic Neurons.
MeSH Terms
- Aging
- Animals
- Cells, Cultured
- Cellular Senescence
- Cyclin-Dependent Kinase Inhibitor p21
- Dopaminergic Neurons
- Epigenetic Repression
- Gene Knockdown Techniques
- Humans
- Matrix Attachment Region Binding Proteins
- Mice
- Mice, Knockout
- Mitosis
- Parkinson Disease
- Protein Binding
Keywords
- Parkinson’s disease
- SATB1
- cellular senescence
- dopamine
- neurodegeneration
- neuroinflammation
- p21
- senolytics
- stem cells
- transcriptomics
SCD
Cognitive training and brain stimulation in prodromal Alzheimer's disease (AD-Stim)-study protocol for a double-blind randomized controlled phase IIb (monocenter) trial.
Blood Pressure in Different Dementia Disorders, Mild Cognitive Impairment, and Subjective Cognitive Decline.
Known-Groups and Convergent Validity of the Telephone Rey Auditory Verbal Learning Test total Learning Scores for Distinguishing Between Older Adults With Amnestic Cognitive Impairment and Subjective Cognitive Decline.
Subjective cognitive decline as a predictor of future cognitive decline: a systematic review.
Geriatric assessment for older adults with sickle cell disease: protocol for a prospective cohort pilot study.
Prevalence and psychosocial correlates of subjectively perceived decline in five cognitive domains: Results from a population-based cohort study in Germany.
SC411 treatment can enhance survival in a mouse model of sickle cell disease.
DNA fragmentation of human spermatozoa: Simple assessment of single- and double-strand DNA breaks and their respective dynamic behavioral response.
Psychometric Cognitive Decline Precedes the Advent of Subjective Cognitive Decline in the Evolution of Alzheimer's Disease.
Serum alkaline phosphatase is elevated and inversely correlated with cognitive functions in subjective cognitive decline: results from the ReGAl 2.0 project.
Changes in Activity Participation Among Older Adults With Subjective Cognitive Decline or Objective Cognitive Deficits.
Age, gender and drug therapy influences on Tpeak-tend interval and on electrical risk score.
Comorbid Chronic Conditions Among Older Adults with Subjective Cognitive Decline, United States, 2015-2017.
Resting State BOLD Variability Is Linked to White Matter Vascular Burden in Healthy Aging but Not in Older Adults With Subjective Cognitive Decline.
Estimated Life Expectancy and Income of Patients With Sickle Cell Disease Compared With Those Without Sickle Cell Disease.
Does Empirically Derived Classification of Individuals with Subjective Cognitive Complaints Predict Dementia?
Spatiotemporal Oscillatory Patterns During Working Memory Maintenance in Mild Cognitive Impairment and Subjective Cognitive Decline.
MeSH Terms
- Aged
- Aging
- Brain Waves
- Cerebral Cortex
- Cognitive Dysfunction
- Cortical Synchronization
- Female
- Humans
- Magnetoencephalography
- Male
- Memory, Short-Term
- Task Performance and Analysis
Keywords
- Alzheimer’s disease (AD)
- Induced oscillatory activity
- magnetoencephalography (MEG)
- mild cognitive impairment (MCI)
- subjective cognitive decline (SCD)
- working memory (WM)
Microstructural Correlates and Laterality Effect of Prospective Memory in Non-Demented Adults with Memory Complaints.
MeSH Terms
- Aged
- Aged, 80 and over
- Corpus Callosum
- Diffusion Tensor Imaging
- Female
- Frontal Lobe
- Functional Laterality
- Humans
- Magnetic Resonance Imaging
- Male
- Memory Disorders
- Middle Aged
- Nerve Fibers
- Neuropsychological Tests
- Retrospective Studies
- Surveys and Questionnaires
- Taiwan
Keywords
- Aging
- Alzheimer’s disease
- Cognitive complaints
- Diffusion tensor imaging
- Lateralization
- Prospective memory
- Tract-based spatial statistics
SCN2A
Na 1.2 haploinsufficiency in Scn2a knock-out mice causes an autistic-like phenotype attenuated with age.
SCN2B
MicroRNA‑449a regulates the progression of brain aging by targeting SCN2B in SAMP8 mice.
SCO1
Real-Time PCR Analysis of Metabolism-Related Genes in a Long-Lived Model of C. elegans.
SDC1
Olmesartan alleviates bleomycin-mediated vascular smooth muscle cell senescence via the miR-665/SDC1 axis.
Sulfated syndecan 1 is critical to preventing cellular senescence by modulating fibroblast growth factor receptor endocytosis.
SDHB
Mitochondrial Signatures in Circulating Extracellular Vesicles of Older Adults with Parkinson's Disease: Results from the EXosomes in PArkiNson's Disease (EXPAND) Study.
SDS
Semiautomatic morphometric analysis of skeletal muscle obtained by needle biopsy in older adults.
Effects of late-onset dietary intake of salidroside on insulin/insulin-like growth factor-1 (IGF-1) signaling pathway of the annual fish Nothobranchius guentheri.
Quantification of Insoluble Protein Aggregation in Caenorhabditis elegans during Aging with a Novel Data-Independent Acquisition Workflow.
Skeletal Muscle Myofibrillar Protein Abundance Is Higher in Resistance-Trained Men, and Aging in the Absence of Training May Have an Opposite Effect.
Characterization, evaluation of nutritional parameters of Radix isatidis protein and its antioxidant activity in D-galactose induced ageing mice.
MeSH Terms
- Aging
- Animals
- Antioxidants
- Catalase
- Drugs, Chinese Herbal
- Galactose
- Humans
- Kidney
- Liver
- Male
- Malondialdehyde
- Mice
- Mice, Inbred ICR
- Molecular Weight
- Oxidative Stress
- Plant Proteins
- Plant Roots
- Superoxide Dismutase
Keywords
- Antioxidant activity
- D-galactose
- Oxidative damage
- Protein composition
- Radix isatidis protein
[Effects of silver nanoparticles on pupation, eclosion, life span, apoptosis and protein expression in Drosophila melanogaster].
Does an Age-Specific Treatment Program Augment the Efficacy of a Cognitive-Behavioral Weight Loss Program in Adolescence and Young Adulthood? Results from a Controlled Study.
SELENBP1
A Caenorhabditis elegans ortholog of human selenium-binding protein 1 is a pro-aging factor protecting against selenite toxicity.
MeSH Terms
- Animals
- Caenorhabditis elegans
- Caenorhabditis elegans Proteins
- Cytoplasm
- Drug Resistance
- Gene Expression Regulation
- Humans
- Longevity
- Membrane Proteins
- Oxidative Stress
- Paraquat
- Selenious Acid
- Selenium-Binding Proteins
- Structural Homology, Protein
Keywords
- Caenorhabditis elegans
- Lifespan
- Selenium-binding protein
- Stress signaling
SELENOK
Dietary selenium deficiency and supplementation differentially modulate the expression of two ER-resident selenoproteins (selenoprotein K and selenoprotein M) in the ovaries of aged mice: Preliminary data.
SENP6
Molecular signature for senile and complicated cataracts derived from analysis of sumoylation enzymes and their substrates in human cataract lenses.
SERPINE1
Elevated circulating HtrA4 in preeclampsia may alter endothelial expression of senescence genes.
SESN2
Copy Number Alterations in Papillary Thyroid Carcinomas: Does Loss of [i]SESN2[/i] Have a Role in Age-related Different Prognoses?
SFN
The phytoprotective agent sulforaphane prevents inflammatory degenerative diseases and age-related pathologies via Nrf2-mediated hormesis.
Multi-Omic Analysis Reveals Different Effects of Sulforaphane on the Microbiome and Metabolome in Old Compared to Young Mice.
Sulforaphane controls the release of paracrine factors by keratinocytes and thus mitigates particulate matter-induced premature skin aging by suppressing melanogenesis and maintaining collagen homeostasis.
Sulforaphane Inhibits Autophagy and Induces Exosome-Mediated Paracrine Senescence via Regulating mTOR/TFE3.
SFPQ
Downregulation of LncRNA NORAD promotes Ox-LDL-induced vascular endothelial cell injury and atherosclerosis.
SGK1
Epigenetic Regulation of KL (Klotho) via H3K27me3 (Histone 3 Lysine [K] 27 Trimethylation) in Renal Tubule Cells.
SHBG
Endogenous Testosterone Levels and the Risk of Incident Cardiovascular Events in Elderly Men: The MrOS Prospective Study.
Associations of Endogenous Sex Hormones with Carotid Plaque Burden and Characteristics in Midlife Women.
Analysis of the Relationship between the Levels of Androgens and Biochemical Bone Markers in Men Aged 60-75 Years.
MeSH Terms
- Absorptiometry, Photon
- Aged
- Aging
- Androgens
- Biomarkers
- Bone Density
- Bone Remodeling
- Bone and Bones
- Collagen Type I
- Dehydroepiandrosterone Sulfate
- Estradiol
- Humans
- Male
- Middle Aged
- Parathyroid Hormone
- Peptide Fragments
- Peptides
- Procollagen
- Sex Hormone-Binding Globulin
- Testosterone
Keywords
- aging men
- biochemical bone markers
- levels of androgens
Testosterone and Estrone Increase From the Age of 70 Years: Findings From the Sex Hormones in Older Women Study.
SHD
Does self-reported hearing difficulty decrease older adults' cognitive and physical functioning? The mediating role of social isolation.
MeSH Terms
- Activities of Daily Living
- Aged
- Aged, 80 and over
- Cognition
- Cognitive Dysfunction
- Cohort Studies
- Disabled Persons
- Female
- Health Status
- Hearing Loss
- Humans
- Longevity
- Longitudinal Studies
- Male
- Mental Status and Dementia Tests
- Odds Ratio
- Self Report
- Social Isolation
Keywords
- Cognitive impairment
- Older people
- Physical disability
- Self-reported hearing difficulty
- Social isolation
SHH
Recent advances in SHH medulloblastoma progression: tumor suppressor mechanisms and the tumor microenvironment.
SI
Microarray Profiling Reveals Distinct Circulating miRNAs in Aged Male and Female Mice Subjected to Post-stroke Social Isolation.
Is Heart Rate a Confounding Factor for Photoplethysmography Markers? A Systematic Review.
MeSH Terms
- Aging
- Cardiovascular Diseases
- Diabetes Mellitus, Type 2
- Female
- Fingers
- Heart Rate
- Humans
- Male
- Microcirculation
- Photoplethysmography
- Vascular Stiffness
Keywords
- cardiovascular disease
- heart rate
- photoplethysmography
- reflection index
- second derivative of photoplethysmography
- stiffness index
Survival time after marked reduction in oral intake in terminally ill noncancer patients: A retrospective study.
Adherence to Mediterranean diet moderates the association between multimorbidity and depressive symptoms in older adults.
Loneliness, Social Isolation, and Objectively Measured Physical Activity in Rural-Living Older Adults.
The associations between social support and negative social interaction with suicidal ideation in US Chinese older adults.
Cell Senescence and Cerebral Small Vessel Disease in the Brains of People Aged 80 Years and Older.
SIK3
Quantitative and Qualitative Role of Antagonistic Heterogeneity in Genetics of Blood Lipids.
SIRT1
Anthocyanins attenuate endothelial dysfunction through regulation of uncoupling of nitric oxide synthase in aged rats.
Sirtuins and Their Implications in Neurodegenerative Diseases from a Drug Discovery Perspective.
Effects of alpha-mangostin on memory senescence induced by high glucose in human umbilical vein endothelial cells.
SIRT1 Activation Using CRISPR/dCas9 Promotes Regeneration of Human Corneal Endothelial Cells through Inhibiting Senescence.
Histone Deacetylase SIRT1, Smooth Muscle Cell Function, and Vascular Diseases.
6,4'-dihydroxy-7-methoxyflavanone protects against H O -induced cellular senescence by inducing SIRT1 and inhibiting phosphatidylinositol 3-kinase/Akt pathway activation.
Isoparvifuran isolated from Dalbergia odorifera attenuates H O -induced senescence of BJ cells through SIRT1 activation and AKT/mTOR pathway inhibition.
SIRT1 Is the Target Gene for 2,3,5,4'-Tetrahydroxystilbene-2-O-β-D-Glucoside Alleviating the HUVEC Senescence.
The Role of Sirtuins in Kidney Diseases.
The effect of 12-week resistance exercise training on serum levels of cellular aging process parameters in elderly men.
Virus-Induced Asthma Exacerbations: SIRT1 Targeted Approach.
Novel resveratrol derivatives have diverse effects on the survival, proliferation and senescence of primary human fibroblasts.
Glucose restriction delays senescence and promotes proliferation of HUVECs via the AMPK/SIRT1-FOXA3-Beclin1 pathway.
Therapeutic Effects of SRT2104 on Lung Injury in Rats with Emphysema via Reduction of Type II Alveolar Epithelial Cell Senescence.
Latifolin Inhibits Oxidative Stress-Induced Senescence via Upregulation of SIRT1 in Human Dermal Fibroblasts.
SRT1720-induced activation of SIRT1 alleviates vascular smooth muscle cell senescence through PKA-dependent phosphorylation of AMPKα at Ser485.
miR-128 plays a critical role in murine osteoclastogenesis and estrogen deficiency-induced bone loss.
Lymphocyte senescence in COPD is associated with decreased sirtuin 1 expression in steroid resistant pro-inflammatory lymphocytes.
Therapeutic effects of hydro-alcoholic leaf extract of Withania somnifera on age-induced changes in daily rhythms of Sirt1, Nrf2 and Rev-erbα in the SCN of male Wistar rats.
The Serum Concentration of Anti-Aging Proteins, Sirtuin1 and αKlotho in Patients with End-Stage Kidney Disease on Maintenance Hemodialysis.
MeSH Terms
- Age Factors
- Aged
- Aging
- Biomarkers
- Blood Pressure
- Cardiovascular Diseases
- Case-Control Studies
- Diabetes Complications
- Echocardiography
- Female
- Glucuronidase
- Heart Ventricles
- Humans
- Kidney
- Kidney Failure, Chronic
- Male
- Middle Aged
- Renal Dialysis
- Sirtuin 1
- Stroke Volume
Keywords
- chronic kidney disease
- hemodialysis
- sirtuin1
- αKlotho
Small extracellular vesicles deliver miR-21 and miR-217 as pro-senescence effectors to endothelial cells.
Spatiotemporal gating of SIRT1 functions by O-GlcNAcylation is essential for liver metabolic switching and prevents hyperglycemia.
MeSH Terms
- Acetylglucosamine
- Aging
- Animals
- Fasting
- Gluconeogenesis
- Glycosylation
- HEK293 Cells
- Homeostasis
- Humans
- Hyperglycemia
- Insulin Resistance
- Liver
- Male
- Mice
- Mice, Inbred C57BL
- Obesity
- Phosphorylation
- Protein Processing, Post-Translational
- Sirtuin 1
- Spatio-Temporal Analysis
Keywords
- PGC1α
- fed–fast cycle
- gluconeogenesis
- insulin signaling
- ubiquitinylation
Hydrogen Sulfide Inhibits Homocysteine-Induced Neuronal Senescence by Up-Regulation of SIRT1.
SIRT1 and aging related signaling pathways.
Tropisetron protects against brain aging via attenuating oxidative stress, apoptosis and inflammation: The role of SIRT1 signaling.
MeSH Terms
- Aging
- Animals
- Antioxidants
- Apoptosis
- Brain
- Drug Administration Schedule
- Galactose
- Gene Expression Regulation
- Inflammation
- Injections, Intraperitoneal
- Injections, Subcutaneous
- Interleukin-6
- Male
- Mice
- Mitochondria
- Neurons
- Nitric Oxide
- Oxidative Stress
- Proto-Oncogene Proteins c-bcl-2
- Reactive Oxygen Species
- Serotonin 5-HT3 Receptor Antagonists
- Sirtuin 1
- Tropisetron
- Tumor Necrosis Factor-alpha
- bcl-2-Associated X Protein
Keywords
- Aging
- Brain
- Neurotoxicity
- Sirtuin 1
- Tropisetron
- d-galactose
Nicotinamide mononucleotide (NMN) supplementation promotes neurovascular rejuvenation in aged mice: transcriptional footprint of SIRT1 activation, mitochondrial protection, anti-inflammatory, and anti-apoptotic effects.
Deacetylation of MRTF-A by SIRT1 defies senescence induced down-regulation of collagen type I in fibroblast cells.
MeSH Terms
- Acetylation
- Animals
- Benzamides
- Carbazoles
- Cellular Senescence
- Collagen Type I
- Down-Regulation
- Embryo, Mammalian
- Fibroblasts
- HEK293 Cells
- Heterocyclic Compounds, 4 or More Rings
- Humans
- Mice
- Mutation
- Naphthols
- Primary Cell Culture
- Promoter Regions, Genetic
- RNA, Small Interfering
- Resveratrol
- Sirtuin 1
- Trans-Activators
Keywords
- Collagen type I
- Fibroblast
- Lysine deacetylation
- Post-translational modification
- Senescence
- Transcriptional regulation
Chronic Polyphenon-60 or Catechin Treatments Increase Brain Monoamines Syntheses and Hippocampal SIRT1 Levels Improving Cognition in Aged Rats.
MeSH Terms
- Age Factors
- Animals
- Behavior, Animal
- Biogenic Monoamines
- Catechin
- Cognition
- Cognitive Aging
- Corpus Striatum
- Hippocampus
- Male
- Memory, Episodic
- Memory, Short-Term
- Neuroprotective Agents
- Rats, Sprague-Dawley
- Sirtuin 1
- Time Factors
Keywords
- NF-κB
- RBAP46/48
- SIRT1
- brain aging
- brain monoamine synthesis
- catechin
- green tea
- memory
Duck Oil-loaded Nanoemulsion Inhibits Senescence of Angiotensin II-treated Vascular Smooth Muscle Cells by Upregulating SIRT1.
Hydrogen sulfide attenuates mitochondrial dysfunction-induced cellular senescence and apoptosis in alveolar epithelial cells by upregulating sirtuin 1.
The protective role of omentin-1 in IL-1β-induced chondrocyte senescence.
MeSH Terms
- Adipokines
- Caveolin 1
- Cell Line, Tumor
- Cellular Senescence
- Chondrocytes
- Cyclin-Dependent Kinase Inhibitor p21
- Cytoprotection
- G1 Phase Cell Cycle Checkpoints
- Humans
- Interleukin-1beta
- Plasminogen Activator Inhibitor 1
- Sirtuin 1
- Transcriptional Activation
Keywords
- IL-1β
- Omentin-1
- SIRT-1
- chondrocyte senescence
The Lifespan Extension Ability of Nicotinic Acid Depends on Whether the Intracellular NAD Level Is Lower than the Sirtuin-Saturating Concentrations.
Alpha-mangostin decreased cellular senescence in human umbilical vein endothelial cells.
Central nervous system SIRT1 expression is required for cued and contextual fear conditioning memory responses in aging mice.
Does education level protect us from rapid ageing? Sirtuin expression versus age and level of education.
MeSH Terms
- Adolescent
- Adult
- Age Factors
- Aging
- Aging, Premature
- Educational Status
- Epigenesis, Genetic
- Female
- Gene Expression Regulation, Enzymologic
- Histones
- Humans
- Learning
- Male
- Middle Aged
- Sirtuins
- Young Adult
CO ameliorates endothelial senescence induced by 5-fluorouracil through SIRT1 activation.
MeSH Terms
- Antioxidants
- Carbon Monoxide
- Cellular Senescence
- Down-Regulation
- Fluorouracil
- Heme Oxygenase-1
- Human Umbilical Vein Endothelial Cells
- Humans
- Nitric Oxide Synthase Type III
- Reactive Oxygen Species
- Sirtuin 1
Keywords
- 5-Fluorouracil
- Carbon monoxide
- Endothelial senescence
- Reactive oxygen species
- SIRT1
Long noncoding RNA GAS5 inhibits cell proliferation and fibrosis in diabetic nephropathy by sponging miR-221 and modulating SIRT1 expression.
MeSH Terms
- Aging
- Animals
- Argonaute Proteins
- Cell Proliferation
- Diabetes Mellitus, Experimental
- Diabetic Nephropathies
- Fibrosis
- Gene Deletion
- Gene Expression Regulation
- Glucose
- Male
- Mesangial Cells
- Mice
- MicroRNAs
- RAW 264.7 Cells
- RNA, Long Noncoding
- Rats
- Rats, Sprague-Dawley
- Sirtuin 1
Keywords
- diabetic nephropathy
- fibrosis
- lncRNA GAS5
- proliferation
The Role of Sirtuin1 in Regulating Endothelial Function, Arterial Remodeling and Vascular Aging.
Deacetylation of LAMP1 drives lipophagy-dependent generation of free fatty acids by Abrus agglutinin to promote senescence in prostate cancer.
Plasma exosomes in OSA patients promote endothelial senescence: effect of long-term adherent continuous positive airway pressure.
Hydrogen Sulfide Inhibits High Glucose-Induced Neuronal Senescence by Improving Autophagic Flux [i]via[/i] Up-regulation of SIRT1.
Activation of the miR-34a-Mediated SIRT1/mTOR Signaling Pathway by Urolithin A Attenuates D-Galactose-Induced Brain Aging in Mice.
SIRT2
Melatonin ameliorates the advanced maternal age-associated meiotic defects in oocytes through the SIRT2-dependent H4K16 deacetylation pathway.
SIRT3
SIRT3 protects endothelial cells from high glucose-induced senescence and dysfunction via the p53 pathway.
Melatonin and Sirtuins in Buccal Epithelium: Potential Biomarkers of Aging and Age-Related Pathologies.
[i]SIRT3[/i] Transfection of Aged Human Bone Marrow-Derived Mesenchymal Stem Cells Improves Cell Therapy-Mediated Myocardial Repair.
17β-estradiol inhibits H O -induced senescence in HUVEC cells through upregulating SIRT3 expression and promoting autophagy.
CR6 interacting factor 1 deficiency induces premature senescence via SIRT3 inhibition in endothelial cells.
Mitochondrial function in skeletal myofibers is controlled by a TRF2-SIRT3 axis over lifetime.
Context-Dependent Roles for SIRT2 and SIRT3 in Tumor Development Upon Calorie Restriction or High Fat Diet.
The yin and yang faces of the mitochondrial deacetylase sirtuin 3 in age-related disorders.
SIRT5
Lysine malonylation and propionylation are prevalent in human lens proteins.
MeSH Terms
- Aging
- Animals
- Blotting, Western
- Chromatography, Liquid
- Crystallins
- Cytoskeletal Proteins
- Cytosol
- Epithelial Cells
- Humans
- Immunohistochemistry
- Lens, Crystalline
- Lysine
- Malonates
- Membrane Proteins
- Mice, Inbred C57BL
- Mice, Knockout
- Middle Aged
- Mitochondrial Proteins
- Organ Culture Techniques
- Paraffin Embedding
- Propionates
- Sirtuin 3
- Sirtuins
- Tandem Mass Spectrometry
Keywords
- Lens proteins
- Malonylation
- Mass spectrometry
- Propionylation
- Sirtuins
SIRT6
Association between SIRT6 Methylation and Human Longevity in a Chinese Population.
The SIRT6 activator MDL-800 improves genomic stability and pluripotency of old murine-derived iPS cells.
Sirtuins as Possible Predictors of Aging and Alzheimer's Disease Development: Verification in the Hippocampus and Saliva.
Age-related epigenetic drift deregulates [i]SIRT6[/i] expression and affects its downstream genes in human peripheral blood mononuclear cells.
Biological and catalytic functions of sirtuin 6 as targets for small-molecule modulators.
Age-dependent role of SIRT6 in jawbone via regulating senescence and autophagy of bone marrow stromal cells.
Mechanism of activation for the sirtuin 6 protein deacylase.
MeSH Terms
- Allosteric Regulation
- Biocatalysis
- Fatty Acids
- HEK293 Cells
- Histones
- Humans
- Hydrophobic and Hydrophilic Interactions
- Kinetics
- Lipids
- Mutagenesis
- Mutation
- NAD
- Peptides
- Protein Binding
- Protein Conformation
- Sirtuins
- Small Molecule Libraries
Keywords
- SIRT6
- activator
- cancer
- chromatin
- deacetylation
- epigenetics
- histone
- histone deacetylase (HDAC)
- lifespan
- long chain acyl substrate
- longevity
- sirtuin
Proteomics of Long-Lived Mammals.
Sirtuins and SIRT6 in Carcinogenesis and in Diet.
SIRT6-mediated transcriptional suppression of MALAT1 is a key mechanism for endothelial to mesenchymal transition.
SIRT7
SIRT7 antagonizes human stem cell aging as a heterochromatin stabilizer.
SLA
Vaccination of aged mice with adjuvanted recombinant influenza nucleoprotein enhances protective immunity.
Mechanical Anisotropy and Surface Roughness in Additively Manufactured Parts Fabricated by Stereolithography (SLA) Using Statistical Analysis.
The Effect of Age of Titanium Dental Implants on Implant Survival and Marginal Bone Resorption: A 5-Year Retrospective Follow-Up Study.
SLC16A7
Genetics of facial telangiectasia in the Rotterdam Study: a genome-wide association study and candidate gene approach.
SLC26A2
Phenotypic characterization of Slc26a2 mutant mice reveals a multifactorial etiology of spondylolysis.
SLC6A4
The Psilocybin-Telomere Hypothesis: An empirically falsifiable prediction concerning the beneficial neuropsychopharmacological effects of psilocybin on genetic aging.
MeSH Terms
- Aging
- Aging, Premature
- Animals
- Anxiety
- Brain-Derived Neurotrophic Factor
- Consciousness
- DNA Methylation
- Depression
- Disease Models, Animal
- Endocrine System
- Humans
- Models, Genetic
- Models, Psychological
- Neurotransmitter Agents
- Oxidative Stress
- Personality
- Psilocybin
- Psychotropic Drugs
- Research Design
- Serotonin Plasma Membrane Transport Proteins
- Stress, Psychological
- Telomere Shortening
Keywords
- Cellular senescence
- Depression
- Epigenetic clock
- Genetic aging
- Life extension
- Neurophenomenology
- Psilocybin
- Rejuvenation
- Rumination
- Senotherapy
- Telomeres
SMAD1
TGFB1-Mediated Gliosis in Multiple Sclerosis Spinal Cords Is Favored by the Regionalized Expression of HOXA5 and the Age-Dependent Decline in Androgen Receptor Ligands.
MeSH Terms
- Age Factors
- Aged
- Aging
- Brain
- Data Mining
- Databases, Genetic
- Disease Progression
- Female
- Gene Expression Profiling
- Gliosis
- Homeodomain Proteins
- Humans
- Ligands
- Male
- Middle Aged
- Multiple Sclerosis
- Proteomics
- Receptors, Androgen
- Sequence Analysis, RNA
- Signal Transduction
- Smad1 Protein
- Spinal Cord
- Transforming Growth Factor beta1
- Up-Regulation
Keywords
- androgen receptor
- astrocytes
- homeobox A5
- multiple sclerosis
- spinal cord
- transforming growth factor beta 1
SMAD2
Prostate epithelial-specific expression of activated PI3K drives stromal collagen production and accumulation.
MeSH Terms
- Aging
- Animals
- Class I Phosphatidylinositol 3-Kinases
- Collagen
- Disease Models, Animal
- Disease Progression
- Epithelium
- Male
- Mice, Mutant Strains
- Phosphorylation
- Prostate
- Prostatic Hyperplasia
- Prostatic Intraepithelial Neoplasia
- Prostatic Neoplasms
- Signal Transduction
- Smad2 Protein
- Stromal Cells
- Transforming Growth Factor beta
Keywords
- PIK3CA
- cancer
- collagen
- fibrosis
- mouse model
- prostate
- stroma
SMAD3
Sirtuin 6 deficiency transcriptionally up-regulates TGF-β signaling and induces fibrosis in mice.
MeSH Terms
- Aging
- Animals
- Fibroblasts
- Fibrosis
- Gene Deletion
- Male
- Mice
- Myocardium
- Myofibroblasts
- Signal Transduction
- Sirtuins
- Smad3 Protein
- Transcriptional Activation
- Transforming Growth Factor beta
Keywords
- SIRT6 deacetylase
- SMAD transcription factor
- SMAD3
- TGF-beta signaling
- aging
- aging-associated fibrosis
- caloric restriction
- cardiac disease
- extracellular matrix (ECM)
- fibrosis
- sirtuin
- transforming growth factor beta (TGF-beta)
SMN2
Age-dependent SMN expression in disease-relevant tissue and implications for SMA treatment.
SMS
Does a Live Performance Impact Synchronization to Musical Rhythm in Cognitively Impaired Elderly?
Testing the effectiveness of physical activity advice delivered via text messaging vs. human phone advisors in a Latino population: The On The Move randomized controlled trial design and methods.
SNAP25
The Biological Foundations of Sarcopenia: Established and Promising Markers.
SNCA
Behavioural and dopaminergic changes in double mutated human A30P*A53T alpha-synuclein transgenic mouse model of Parkinson´s disease.
SND1
[Downregulation of SND1 Expression Accelerates Cell Senescence of Human Diploid Fibroblasts 2BS via Modulating the SASP].
SOD1
SOD1, more than just an antioxidant.
The Exacerbation of Aging and Oxidative Stress in the Epididymis of [i]Sod1[/i] Null Mice.
Alterations in lipid metabolism of spinal cord linked to amyotrophic lateral sclerosis.
MeSH Terms
- Aging
- Amyotrophic Lateral Sclerosis
- Animals
- Cardiolipins
- Cholesterol Esters
- Disease Models, Animal
- Disease Progression
- Fatty Acids, Unsaturated
- Female
- Humans
- Lipid Droplets
- Lipid Metabolism
- Lipidomics
- Male
- Mass Spectrometry
- Motor Cortex
- Motor Neurons
- Mutation
- Oxidative Stress
- Rats
- Rats, Transgenic
- Spinal Cord
- Superoxide Dismutase-1
SOD2
Astaxanthin Counteracts Vascular Calcification In Vitro Through an Early Up-Regulation of SOD2 Based on a Transcriptomic Approach.
Alginate Oligosaccharide Prevents against D-galactose-mediated Cataract in C57BL/6J Mice via Regulating Oxidative Stress and Antioxidant System.
Protoflavones in melanoma therapy: Prooxidant and pro-senescence effect of protoapigenone and its synthetic alkyl derivative in A375 cells.
MeSH Terms
- Antineoplastic Agents, Phytogenic
- Autophagy
- Biomarkers
- Cell Cycle
- Cell Line, Tumor
- Cellular Senescence
- Cyclohexanones
- Flavones
- Humans
- Melanoma
- Reactive Oxygen Species
- Superoxide Dismutase
- beta-Galactosidase
Keywords
- Alkyl protoflavone
- Flavonoid
- Melanoma
- Protoapigenone
- Semi-synthesis
- Senescence
Ginsenoside Rg1 protects against Sca-1 HSC/HPC cell aging by regulating the SIRT1-FOXO3 and SIRT3-SOD2 signaling pathways in a γ-ray irradiation-induced aging mice model.
Almond Skin Extracts and Chlorogenic Acid Delay Chronological Aging and Enhanced Oxidative Stress Response in Yeast.
Opposing p53 and mTOR/AKT promote an in vivo switch from apoptosis to senescence upon telomere shortening in zebrafish.
Bioactive peptides derived from crimson snapper and in vivo anti-aging effects on fat diet-induced high fat Drosophila melanogaster.
Ellagic acid prolongs the lifespan of Drosophila melanogaster.
Chlorella vulgaris modulates the expression of senescence-associated genes in replicative senescence of human diploid fibroblasts.
MeSH Terms
- Antioxidants
- Catalase
- Cell Differentiation
- Cell Proliferation
- Cells, Cultured
- Cellular Senescence
- Chlorella vulgaris
- DNA Damage
- Diploidy
- Fibroblasts
- Gene Expression
- Genes, p53
- Humans
- Male
- Mitogen-Activated Protein Kinase 14
- Molecular Chaperones
- Primary Cell Culture
- Signal Transduction
- Superoxide Dismutase
- Superoxide Dismutase-1
Keywords
- Chlorella vulgaris
- Fibroblasts
- Replicative senescence
- Senescence-associated genes
Age-Associated Changes in Antioxidants and Redox Proteins of Rat Heart.
Impact of curcumin on replicative and chronological aging in the Saccharomyces cerevisiae yeast.
SOX13
In silico analysis of human renin gene-gene interactions and neighborhood topologically associated domains suggests breakdown of insulators contribute to ageing-associated diseases.
SOX2
Multiple nanosecond pulsed electric fields stimulation with conductive poly(l-lactic acid)/carbon nanotubes films maintains the multipotency of mesenchymal stem cells during prolonged in vitro culture.
Subpopulations of miniature pig mesenchymal stromal cells with different differentiation potentials differ in the expression of octamer-binding transcription factor 4 and sex determining region Y-box 2.
Increased Type I and Decreased Type II Hair Cells after Deletion of Sox2 in the Developing Mouse Utricle.
SOX4
Age-induced accumulation of methylmalonic acid promotes tumour progression.
MeSH Terms
- Adult
- Aged
- Aging
- Animals
- Cell Line, Tumor
- Disease Progression
- Female
- Gene Expression Regulation, Neoplastic
- Humans
- Male
- Methylmalonic Acid
- Mice
- Middle Aged
- Neoplasm Invasiveness
- Neoplasm Metastasis
- Neoplasms
- SOXC Transcription Factors
- Signal Transduction
- Transcriptome
- Transforming Growth Factor beta
SOX9
Positive Effects of a Young Systemic Environment and High Growth Differentiation Factor 11 Levels on Chondrocyte Proliferation and Cartilage Matrix Synthesis in Old Mice.
MeSH Terms
- Adolescent
- Aged
- Aging
- Animals
- Arthroplasty, Replacement, Knee
- Bone Morphogenetic Proteins
- Cartilage, Articular
- Cell Proliferation
- Chondrocytes
- Collagen Type II
- Collagen Type X
- Core Binding Factor Alpha 1 Subunit
- Extracellular Matrix
- Female
- Growth Differentiation Factors
- Humans
- In Vitro Techniques
- Knee Joint
- Male
- Matrix Metalloproteinase 13
- Mice
- Osteoarthritis, Knee
- Parabiosis
- Phosphorylation
- RNA, Messenger
- Reverse Transcriptase Polymerase Chain Reaction
- SOX9 Transcription Factor
- Smad2 Protein
- Smad3 Protein
- Stifle
- Young Adult
SPARC
SPARC Metrics Provide Mobility Smoothness Assessment in Oldest-Old With and Without a History of Falls: A Case Control Study.
Reduced fibrillar collagen accumulation in skeletal muscle of secreted protein acidic and rich in cysteine (SPARC)-null mice.
SPR
Regulation of lifespan by neural excitation and REST.
MeSH Terms
- Aging
- Animals
- Brain
- Caenorhabditis elegans
- Caenorhabditis elegans Proteins
- DNA-Binding Proteins
- Forkhead Transcription Factors
- Humans
- Longevity
- Mice
- Mice, 129 Strain
- Mice, Inbred C57BL
- Mice, Knockout
- Mice, Transgenic
- Neurons
- RNA Interference
- RNA-Binding Proteins
- Repressor Proteins
- Transcription Factors
SPRTN
Tandem Deubiquitination and Acetylation of SPRTN Promotes DNA-Protein Crosslink Repair and Protects against Aging.
MeSH Terms
- Acetylation
- Aging
- Animals
- Cell Line
- DNA Damage
- DNA Repair
- DNA-Binding Proteins
- Deubiquitinating Enzymes
- Endopeptidases
- Female
- Genomic Instability
- HEK293 Cells
- Humans
- Male
- Mice, Inbred C57BL
- Mice, Knockout
- Phosphorylation
- Protein Domains
- Protein Processing, Post-Translational
- Ubiquitination
Keywords
- DNA repair
- DNA-protein crosslink
- SPRTN
- Top1cc
- VCPIP1/VCIP135
- acetylation
- aging
- genomic instability
- metalloprotease
- ubiquitination
SPRY1
Sprouty1 Prevents Cellular Senescence Maintaining Proliferation and Differentiation Capacity of Human Adipose Stem/Progenitor Cells.
Mechanism of SPRY1 methylation regulating natural aging of skin epidermal cells.
SQSTM1
The selective autophagy receptor SQSTM1/p62 improves lifespan and proteostasis in an evolutionarily conserved manner.
SRC
Metabolic characteristics of CD8 T cell subsets in young and aged individuals are not predictive of functionality.
MeSH Terms
- Adult
- Aged
- Aging
- Animals
- CD8-Positive T-Lymphocytes
- Cell Differentiation
- Cell Proliferation
- Disease Models, Animal
- Female
- Humans
- Immunologic Memory
- Influenza A virus
- Influenza, Human
- Male
- Mice
- Microscopy, Electron, Transmission
- Mitochondria
- T-Lymphocyte Subsets
- Young Adult
SRD5A2
Extract of Plumbago zeylanica enhances the growth of hair follicle dermal papilla cells with down-regulation of 5α-reductase type II.
SRF
Changes in snail and SRF expression in the kidneys of diabetic rats during ageing.
Mechanosensitive transcriptional coactivators MRTF-A and YAP/TAZ regulate nucleus pulposus cell phenotype through cell shape.
MeSH Terms
- Actins
- Adaptor Proteins, Signal Transducing
- Aging
- Biomechanical Phenomena
- Cells, Cultured
- Cytoskeleton
- Gene Expression Regulation
- Humans
- Hydrogels
- Intervertebral Disc Degeneration
- Nucleus Pulposus
- RNA Interference
- Trans-Activators
- Transcription Factors
- rho-Associated Kinases
Keywords
- F-actin
- SRF
- TEAD
- intervertebral disc
- mechanotransduction
SRL
Income dividends and subjective survival in a Cherokee Indian cohort: a quasi-experiment.
SRM
[Geriatric specificities of localized renal cell carcinoma].
SSB
Modelling the Effects of Beverage Substitution during Adolescence on Later Obesity Outcomes in Early Adulthood: Results from the Raine Study.
SST
The distance to death perceptions of older adults explain why they age in place: A theoretical examination.
Population Segmentation Based on Healthcare Needs: Validation of a Brief Clinician-Administered Tool.
Examination on how emotion regulation mediates the relationship between future time perspective and well-being: a counter-evidence to the socioemotional selectivity theory.
STAT1
STAT1-p53-p21axis-dependent stress-induced progression of chronic nephrosis in adriamycin-induced mouse model.
Age-Dependent and -Independent Effects of Perivascular Adipose Tissue and Its Paracrine Activities during Neointima Formation.
Legumain-deficient macrophages promote senescence of tumor cells by sustaining JAK1/STAT1 activation.
MeSH Terms
- Animals
- Bone Marrow Transplantation
- Breast Neoplasms
- Cell Cycle Proteins
- Cell Line, Tumor
- Cellular Senescence
- Disease Models, Animal
- Female
- Gene Expression Regulation, Neoplastic
- Humans
- Integrin alphaVbeta3
- Interleukin-1beta
- Janus Kinase 1
- Macrophage Activation
- Macrophages
- Mice
- Mice, Knockout
- STAT1 Transcription Factor
- Signal Transduction
Keywords
- Cellular senescence
- Legumain
- M1 polarization
- Tumor-associated macrophage
STAT3
Dietary Restriction Suppresses Steatosis-Associated Hepatic Tumorigenesis in Hepatitis C Virus Core Gene Transgenic Mice.
Skeletal glucocorticoid signalling determines leptin resistance and obesity in aging mice.
AMPK alleviates oxidative stress‑induced premature senescence via inhibition of NF-κB/STAT3 axis-mediated positive feedback loop.
Age-related loss of neural stem cell O-GlcNAc promotes a glial fate switch through STAT3 activation.
MeSH Terms
- Aging
- Animals
- Cell Differentiation
- Cell Proliferation
- Computational Biology
- Gene Expression Regulation
- Glucosamine
- Hippocampus
- Mice
- Neural Stem Cells
- Neurogenesis
- Neuroglia
- STAT3 Transcription Factor
- Sequence Analysis, RNA
Keywords
- O-GlcNAcylation
- aging
- gliogenesis
- neural stem cells
- neurogenesis
Cell Death by Gallotannin Is Associated with Inhibition of the JAK/STAT Pathway in Human Colon Cancer Cells.
The effect of interleukin 6 deficiency on myocardial signal transduction pathways activation induced by bacterial lipopolysaccharide in young and old mice.
Silibinin and SARS-CoV-2: Dual Targeting of Host Cytokine Storm and Virus Replication Machinery for Clinical Management of COVID-19 Patients.
Implication of JAK1/STAT3/SOCS3 Pathway in Aging of Cerebellum of Male Rat: Histological and Molecular study.
MeSH Terms
- Aging
- Animals
- Caspase 3
- Cerebellum
- Glial Fibrillary Acidic Protein
- Glutathione
- Immunohistochemistry
- Janus Kinase 1
- Male
- Malondialdehyde
- Microscopy, Electron
- Rats
- Rats, Wistar
- STAT3 Transcription Factor
- Signal Transduction
- Suppressor of Cytokine Signaling 3 Protein
- Tumor Necrosis Factor-alpha
Atorvastatin-induced senescence of hepatocellular carcinoma is mediated by downregulation of hTERT through the suppression of the IL-6/STAT3 pathway.
Deciphering the Molecular Mechanism of Spontaneous Senescence in Primary Epithelial Ovarian Cancer Cells.
Persistent Activation of STAT3 Pathway in the Retina Induced Vision Impairment and Retinal Degenerative Changes in Ageing Mice.
MeSH Terms
- Aging
- Animals
- Mice
- Mice, Inbred C57BL
- Retina
- Retinal Degeneration
- STAT3 Transcription Factor
- Suppressor of Cytokine Signaling 3 Protein
- Suppressor of Cytokine Signaling Proteins
- Uveitis
Keywords
- EAU
- Experimental autoimmune uveitis
- Retinal dystrophies
- SOCS3
- STAT3
- Transgenic mouse
- Uveitis
Interleukin-10 induces senescence of activated hepatic stellate cells via STAT3-p53 pathway to attenuate liver fibrosis.
STC2
Genome-wide Associations Reveal Human-Mouse Genetic Convergence and Modifiers of Myogenesis, CPNE1 and STC2.
MeSH Terms
- Adult
- Aged
- Aging
- Animals
- Body Composition
- Body Weight
- Calcium-Binding Proteins
- Case-Control Studies
- Female
- Follow-Up Studies
- Genome-Wide Association Study
- Glycoproteins
- Humans
- Intercellular Signaling Peptides and Proteins
- Male
- Mice
- Middle Aged
- Muscle Development
- Muscle, Skeletal
- Quantitative Trait Loci
- Thinness
Keywords
- UK Biobank
- human and mouse GWAS
- sarcopenia
- skeletal muscle
STIM1
Progerin in muscle leads to thermogenic and metabolic defects via impaired calcium homeostasis.
MeSH Terms
- Animals
- Calcium
- Calnexin
- Cell Nucleus
- Disease Models, Animal
- Endoplasmic Reticulum
- Endoplasmic Reticulum Stress
- Lamin Type A
- Mice
- Mice, Knockout
- Microscopy, Electron, Transmission
- Muscle Proteins
- Muscle, Skeletal
- Muscular Dystrophies
- Mutation
- Myoblasts
- ORAI1 Protein
- Progeria
- Proteolipids
- Stromal Interaction Molecule 1
- Thermogenesis
- Up-Regulation
Keywords
- aging
- calcium homeostasis
- lamin A
- muscular dystrophy
- progeria
STS
Delayed Impairment of Postural, Physical, and Muscular Functions Following Downhill Compared to Level Walking in Older People.
Autophagy displays divergent roles during intermittent amino acid starvation and toxic stress-induced senescence in cultured skeletal muscle cells.
The WRKY53 transcription factor enhances stilbene synthesis and disease resistance by interacting with MYB14 and MYB15 in Chinese wild grape.
On the role of ageing and musculoskeletal pain on dynamic balance in manual workers.
SUCNR1
[The effect of Mexidol on cerebral mitochondriogenesis at a young age and during aging].
MeSH Terms
- Age Factors
- Aging
- Animals
- Male
- Mitochondria
- Neurodegenerative Diseases
- Picolines
- Rats
- Receptors, G-Protein-Coupled
- Transcription Factors
Keywords
- Western blot analysis
- aging
- cerebral mitochondriogenesis
- mexidol
- mitochondrial dysfunction
- rats
- respiratory enzyme subunits
- succinate receptor
- transcriptional coactivator PGC-1α
SUGCT
Knockout of the non-essential gene SUGCT creates diet-linked, age-related microbiome disbalance with a diabetes-like metabolic syndrome phenotype.
MeSH Terms
- Aging
- Animals
- Anti-Bacterial Agents
- Bacteria
- Carnitine
- Coenzyme A-Transferases
- Dietary Supplements
- Feces
- Gastrointestinal Microbiome
- Humans
- Kidney
- Lipid Metabolism
- Liver
- Lysine
- Metabolic Syndrome
- Metabolome
- Mice
- Mice, Knockout
- Obesity
- Tryptophan
Keywords
- C7orf10
- Glutaric aciduria type 3 (GA3)
- Gut microflora
- Lipids
- Metabolomics
- Obesity
- Sugct
SUV39H1
Increase in hippocampal histone H3K9me3 is negatively correlated with memory in old male mice.
SYK
miR-25-3p promotes endothelial cell angiogenesis in aging mice via TULA-2/SYK/VEGFR-2 downregulation.
Identification of SYK inhibitor, R406 as a novel senolytic agent.
SYNE1
Nesprin-1 impact on tumorigenic cell phenotypes.
MeSH Terms
- Actins
- Carcinogenesis
- Cell Line, Tumor
- Cell Nucleus
- Cytoskeletal Proteins
- Gene Expression
- Gene Expression Regulation, Neoplastic
- Humans
- Microfilament Proteins
- Nerve Tissue Proteins
- Nuclear Envelope
- Phenotype
Keywords
- Cancer
- Cellular senescence
- Genome stability
- Nesprin-1
- Nuclear envelope
TAAR1
Minimal Age-Related Alterations in Behavioral and Hematological Parameters in Trace Amine-Associated Receptor 1 (TAAR1) Knockout Mice.
TAS2R16
Taste receptor polymorphisms and longevity: a systematic review and meta-analysis.
TAS2R38
TAS2R38 bitter taste receptor and attainment of exceptional longevity.
TAZ
Transcriptional Coactivator TAZ Negatively Regulates Tumor Suppressor p53 Activity and Cellular Senescence.
TBC1D5
TBC1D5-Catalyzed Cycling of Rab7 Is Required for Retromer-Mediated Human Papillomavirus Trafficking during Virus Entry.
Retromer and TBC1D5 maintain late endosomal RAB7 domains to enable amino acid-induced mTORC1 signaling.
TBK1
Parkin overexpression alleviates cardiac aging through facilitating K63-polyubiquitination of TBK1 to facilitate mitophagy.
TCF7L2
A myelin-related transcriptomic profile is shared by Pitt-Hopkins syndrome models and human autism spectrum disorder.
MeSH Terms
- Aging
- Animals
- Autism Spectrum Disorder
- Cell Count
- DNA Fingerprinting
- Facies
- Gene Expression Regulation
- Humans
- Hyperventilation
- Intellectual Disability
- Methyl-CpG-Binding Protein 2
- Mice
- Mice, Knockout
- Myelin Sheath
- Oligodendroglia
- PTEN Phosphohydrolase
- Primary Cell Culture
- Signal Transduction
- Transcription Factor 4
- Transcriptome
TEC
Vestibular function and cortical and sub-cortical alterations in an aging population.
Metabolic Flexibility and Innate Immunity in Renal Ischemia Reperfusion Injury: The Fine Balance Between Adaptive Repair and Tissue Degeneration.
Postnatal Involution and Counter-Involution of the Thymus.
Gender Disparity Impacts on Thymus Aging and LHRH Receptor Antagonist-Induced Thymic Reconstitution Following Chemotherapeutic Damage.
Clonogenic Culture of Mouse Thymic Epithelial Cells.
MeSH Terms
- Aging
- Animals
- Cell Differentiation
- Cell Line
- Coculture Techniques
- Colony-Forming Units Assay
- DNA-Binding Proteins
- Epithelial Cells
- Flow Cytometry
- Fluorescent Antibody Technique, Direct
- Fluorescent Dyes
- Immunomagnetic Separation
- Mice
- Mice, Knockout
- Primary Cell Culture
- Rhodamines
- Self Tolerance
- Staining and Labeling
- Stem Cells
- Thymus Gland
Keywords
- Clonogenic assay
- Thymic epithelial cells
- Thymic epithelial stem cells
- Thymus
TEF
Expression of human HSP27 in yeast extends replicative lifespan and uncovers a hormetic response.
TERT
Telomeres and telomerase in risk assessment of cardiovascular diseases.
A 4-Base-Pair Core-Enclosing Helix in Telomerase RNA Is Essential for Activity and for Binding to the Telomerase Reverse Transcriptase Catalytic Protein Subunit.
Angiotensin inhibition and cellular senescence in the developing rat kidney.
Decreased expression of TERT and telomeric proteins as human ovaries age may cause telomere shortening.
The secrets of telomerase: Retrospective analysis and future prospects.
Gene expression in human mesenchymal stem cell aging cultures: modulation by short peptides.
Unravelling Cellular Mechanisms of Stem Cell Senescence: An Aid from Natural Bioactive Molecules.
Expression of telomerase reverse transcriptase positively correlates with duration of lithium treatment in bipolar disorder.
MeSH Terms
- Adult
- Aging
- Antimanic Agents
- Bipolar Disorder
- Cellular Senescence
- Female
- Humans
- Lithium
- Lithium Compounds
- Male
- Middle Aged
- Mitochondria
- Oxidative Stress
- Polymorphism, Single Nucleotide
- Real-Time Polymerase Chain Reaction
- Telomerase
- Telomere
- Telomere Homeostasis
- Telomere Shortening
Keywords
- Affective disorder
- Aging
- Mitochondria
- Oxidative stress
- TERT
- Telomere
FAM96B inhibits the senescence of dental pulp stem cells.
Aging and biomarkers: Transcriptional levels evaluation of Osteopontin/miRNA-181a axis in hepatic tissue of rats in different age ranges.
Resveratrol inhibits adipocyte differentiation and cellular senescence of human bone marrow stromal stem cells.
Characterization of human telomerase reverse transcriptase immortalized anterior cruciate ligament cell lines.
Mitochondria, Telomeres and Telomerase Subunits.
Towards Therapeutic Alternatives for Mercury Neurotoxicity in the Amazon: Unraveling the Pre-Clinical Effects of the Superfruit Açaí ([i]Euterpe oleracea[/i], Mart.) as Juice for Human Consumption.
Replication Stress at Telomeric and Mitochondrial DNA: Common Origins and Consequences on Ageing.
MeSH Terms
- Aging
- Animals
- Cellular Senescence
- DNA Damage
- DNA Replication
- DNA, Mitochondrial
- Epigenesis, Genetic
- Humans
- Mitochondria
- Oxidative Stress
- Stress, Physiological
- Telomere
- Telomere Homeostasis
- Telomere Shortening
Keywords
- G-quadruplex
- R-loop
- ageing
- helicase
- mitochondria
- replication stress
- senescence
- telomere
Telomerase Biology Associations Offer Keys to Cancer and Aging Therapeutics.
Transient induction of telomerase expression mediates senescence and reduces tumorigenesis in primary fibroblasts.
MeSH Terms
- Animals
- Cell Cycle
- Cell Transformation, Neoplastic
- Cells, Cultured
- Cellular Senescence
- Fibroblasts
- Gene Expression
- Gene Expression Regulation
- Gene Knockdown Techniques
- Humans
- Mice
- Mice, Inbred C57BL
- Mice, Knockout
- Phenotype
- Telomerase
- Telomere
Keywords
- ATM
- senescence
- telomerase
- tumorigenesis
TET2
Non-coding and Loss-of-Function Coding Variants in TET2 are Associated with Multiple Neurodegenerative Diseases.
MeSH Terms
- Aged
- Aged, 80 and over
- Alzheimer Disease
- Animals
- Cognition
- DNA-Binding Proteins
- Female
- Frontotemporal Dementia
- Humans
- Loss of Function Mutation
- Male
- Mice
- Neurodegenerative Diseases
- Proto-Oncogene Proteins
Keywords
- AD
- ALS
- Alzheimer
- FTD
- TET2
- aging
- amyotrophic lateral sclerosis
- frontotemporal dementia
- genome sequencing
- non-coding
60 Years of clonal hematopoiesis research: From X-chromosome inactivation studies to the identification of driver mutations.
MeSH Terms
- Adult
- Aging
- Biomedical Research
- Chromosomes, Human, X
- DNA-Binding Proteins
- Female
- Hematopoiesis
- Hematopoietic Stem Cells
- History, 20th Century
- History, 21st Century
- Humans
- Male
- Mutation
- Proto-Oncogene Proteins
- Receptors, Androgen
- Repressor Proteins
- X Chromosome Inactivation
DNA methylation instability by BRAF-mediated TET silencing and lifestyle-exposure divides colon cancer pathways.
MeSH Terms
- Animals
- Caco-2 Cells
- Cell Line, Tumor
- Colonic Neoplasms
- DNA Methylation
- DNA-Binding Proteins
- Down-Regulation
- Epigenesis, Genetic
- Female
- Gene Regulatory Networks
- HT29 Cells
- Humans
- Male
- Mice
- Mixed Function Oxygenases
- Mutation
- Neoplasms, Experimental
- Proto-Oncogene Proteins
- Proto-Oncogene Proteins B-raf
Keywords
- Aging
- BRAF V600E
- CIMP
- Colon cancer
- DNA methylation
- TET
Clonal haematopoiesis: connecting ageing and inflammation in cardiovascular disease.
MeSH Terms
- Adult
- Age Factors
- Aged
- Aged, 80 and over
- Aging
- Animals
- Cardiovascular Diseases
- DNA (Cytosine-5-)-Methyltransferases
- DNA-Binding Proteins
- Genetic Predisposition to Disease
- Hematopoiesis
- Hematopoietic Stem Cells
- Humans
- Inflammation
- Middle Aged
- Mutation
- Phenotype
- Proto-Oncogene Proteins
- Repressor Proteins
- Risk Assessment
- Risk Factors
TF
A preliminary investigation of the contribution of different tenderness factors to beef loin, tri-tip and heel tenderness.
The transcription factor ZmNAC126 accelerates leaf senescence downstream of the ethylene signalling pathway in maize.
Extensive transcriptome changes during seasonal leaf senescence in field-grown black cottonwood (Populus trichocarpa Nisqually-1).
Expression of Transferrin and Albumin in the Sperm-Storage Tubules of Japanese Quail and their Possible Involvement in Long-Term Sperm Storage.
OsWRKY5 Promotes Rice Leaf Senescence via Senescence-Associated NAC and Abscisic Acid Biosynthesis Pathway.
BrTCP7 Transcription Factor Is Associated with MeJA-Promoted Leaf Senescence by Activating the Expression of [i]BrOPR3[/i] and [i]BrRCCR[/i].
MeSH Terms
- Amino Acid Sequence
- Brassica
- Cellular Senescence
- Cyclopentanes
- Gene Expression Regulation, Plant
- Oxylipins
- Phenotype
- Phylogeny
- Plant Growth Regulators
- Plant Leaves
- Plant Proteins
- Promoter Regions, Genetic
- Protein Binding
- Transcription Factors
Keywords
- Chinese flowering cabbage
- JA
- leaf senescence
- transcriptional activation
Activation of the Transcription of [i]BrGA20ox3[/i] by a BrTCP21 Transcription Factor Is Associated with Gibberellin-Delayed Leaf Senescence in Chinese Flowering Cabbage during Storage.
MeSH Terms
- Aging
- Base Sequence
- Brassica
- Food Preservation
- Gene Expression Regulation, Plant
- Gibberellins
- Phenotype
- Phylogeny
- Plant Leaves
- Plant Proteins
- Promoter Regions, Genetic
- Protein Binding
- Transcription Factors
Keywords
- Chinese flowering cabbage
- GA
- leaf senescence
- transcriptional activation
TFEB
A Novel Lipofuscin-detecting Marker of Senescence Relates With Hypoxia, Dysregulated Autophagy and With Poor Prognosis in Non-small-cell-lung Cancer.
ESC-sEVs Rejuvenate Senescent Hippocampal NSCs by Activating Lysosomes to Improve Cognitive Dysfunction in Vascular Dementia.
Nitrative Stress-Related Autophagic Insufficiency Participates in Hyperhomocysteinemia-Induced Renal Aging.
Polyamines reverse immune senescence via the translational control of autophagy.
Polyamines Control eIF5A Hypusination, TFEB Translation, and Autophagy to Reverse B Cell Senescence.
MeSH Terms
- Adaptive Immunity
- Age Factors
- Aging
- Animals
- Autophagy
- B-Lymphocytes
- Basic Helix-Loop-Helix Leucine Zipper Transcription Factors
- Cellular Senescence
- HEK293 Cells
- Humans
- Immunologic Memory
- Immunosenescence
- Jurkat Cells
- Mice
- Mice, Inbred C57BL
- Mice, Knockout
- NIH 3T3 Cells
- Peptide Initiation Factors
- Protein Processing, Post-Translational
- RNA-Binding Proteins
- Signal Transduction
- Spermidine
Keywords
- B cell
- TFEB
- aging
- autophagy
- eIF5A
- spermidine
TFPI
Identification of cardiovascular health gene variants related to longevity in a Chinese population.
TG
Inhibition of the alternative lengthening of telomeres pathway by subtelomeric sequences in Saccharomyces cerevisiae.
E4orf1, an Adeno-viral protein, attenuates renal lipid accumulation in high fat fed mice: A novel approach to reduce a key risk factor for chronic kidney disease.
Resistance exercise attenuates postprandial metabolic responses to a high-fat meal similarly in younger and older men.
Aging-induced aberrant RAGE/PPARα axis promotes hepatic steatosis via dysfunctional mitochondrial β oxidation.
Fenofibrate impairs liver function and structure more pronounced in old than young rats.
Awareness of major cardiovascular risk factors and its relationship with markers of vascular aging: Data from the Brisighella Heart Study.
MeSH Terms
- Adolescent
- Adult
- Age Factors
- Aged
- Aged, 80 and over
- Aging
- Biomarkers
- Blood Glucose
- Blood Pressure
- Cardiovascular Diseases
- Cholesterol
- Cross-Sectional Studies
- Diabetes Mellitus
- Female
- Humans
- Hypercholesterolemia
- Hypertension
- Hypertriglyceridemia
- Italy
- Male
- Middle Aged
- Risk Assessment
- Risk Factors
- Triglycerides
- Vascular Stiffness
- Young Adult
Keywords
- Arterial aging
- Awareness
- Epidemiology
- Pulse wave velocity
- Risk factors
Characterisation of the dynamic nature of lipids throughout the lifespan of genetically identical female and male Daphnia magna.
Effects of laboratory biotic aging on the characteristics of biochar and its water-soluble organic products.
Using Caenorhabditis elegans for Studying Trans- and Multi-Generational Effects of Toxicants.
TH
Thyroid hormone signaling is associated with physical performance, muscle mass, and strength in a cohort of oldest-old: results from the Mugello study.
Social Environment Ameliorates Behavioral and Immune Impairments in Tyrosine Hydroxylase Haploinsufficient Female Mice.
Mechanism of thyroid hormone signaling in skeletal muscle of aging mice.
Longitudinal changes in bone mineral density and trabecular bone score in Korean adults: a community-based prospective study.
Quantitative proteomic profiling of the rat substantia nigra places glial fibrillary acidic protein at the hub of proteins dysregulated during aging: Implications for idiopathic Parkinson's disease.
Keywords
- RRID:AB_11145309
- RRID:AB_2109791
- RRID:AB_228307
- RRID:AB_228341
- RRID:AB_2336820
- RRID:AB_2631098
- RRID:AB_390204
- RRID:MGI:5651135
- RRID:SCR_001881
- RRID:SCR_002798
- RRID:SCR_003070
- RRID:SCR_004946
- RRID:SCR_005223
- aging
- dopaminergic neuron
- glial fibrillary acidic protein
- proteome
- proteomics
- substantia nigra
Withaferin-A Protects the Nigral Dopamine Neuron and Recovers Motor Activity in Aged Rats.
Effects of physical activity on bone mineral density in older adults: Korea National Health and Nutrition Examination Survey, 2008-2011.
MeSH Terms
- Absorptiometry, Photon
- Aged
- Bone Density
- Cross-Sectional Studies
- Exercise
- Female
- Femur Neck
- Humans
- Lumbar Vertebrae
- Male
- Middle Aged
- Nutrition Surveys
- Osteoporosis
- Republic of Korea
- Surveys and Questionnaires
Keywords
- Aging
- Bone mineral density
- Exercise
- Gender
- Osteoporosis
- Physical activity
Age-Related Resistance to Thyroid Hormone Action.
Age-Dependent Changes in Glucose Homeostasis in Male Deiodinase Type 2 Knockout Zebrafish.
Age effect on thyroid hormone brain response in male mice.
MeSH Terms
- Aging
- Animals
- Brain
- Gene Expression
- Hyperthyroidism
- Hypothyroidism
- Male
- Maze Learning
- Mice, Inbred C57BL
- Monocarboxylic Acid Transporters
- Organic Cation Transport Proteins
- Rotarod Performance Test
- Symporters
- Thyroid Hormones
- Thyrotropin
- Thyrotropin-Releasing Hormone
Keywords
- Ageing
- Hyperthyroidism
- Hypothyroidism
- Male mice
- Thyroid hormones
Aging Is Associated with Low Thyroid State and Organ-Specific Sensitivity to Thyroxine.
TLR1
Effects of aging and lifelong aerobic exercise on expression of innate immune components in human skeletal muscle.
Association of TLR gene variants in a Czech Red Pied cattle population with reproductive traits.
MeSH Terms
- Age Factors
- Animals
- Breeding
- Cattle
- Czech Republic
- Female
- Genotype
- Longevity
- Male
- Phenotype
- Polymorphism, Single Nucleotide
- Reproduction
- Toll-Like Receptor 1
- Toll-Like Receptor 2
- Toll-Like Receptor 6
- Toll-Like Receptors
Keywords
- Cattle
- Diversity
- Effect prediction
- Health traits
- Toll-like receptors
TLR2
Changes in salivary microbial sensing proteins CD14 and TLR2 with aging.
Culture Model for Non-human Primate Choroid Plexus.
TLR4
Age-Dependent Changes of Adipokine and Cytokine Secretion From Rat Adipose Tissue by Endogenous and Exogenous Toll-Like Receptor Agonists.
Role of Toll Like Receptor 4 in Alzheimer's Disease.
Commentary on Some Recent Theses Relevant to Combating Aging: August 2020.
Sialylation and Galectin-3 in Microglia-Mediated Neuroinflammation and Neurodegeneration.
Chemerin facilitates intervertebral disc degeneration via TLR4 and CMKLR1 and activation of NF-kB signaling pathway.
Toll-like receptor 4 differentially regulates adult hippocampal neurogenesis in an age- and sex-dependent manner.
Aging-associated immunosenescence via alterations in splenic immune cell populations in rat.
Leptin induces immunosenescence in human B cells.
Genetic Variation in the Magnitude and Longevity of the IgG Subclass Response to a Diphtheria-Tetanus-Acellular Pertussis (DTaP) Vaccine in Mice.
Rapamycin improves sevoflurane‑induced cognitive dysfunction in aged rats by mediating autophagy through the TLR4/MyD88/NF‑κB signaling pathway.
TLR9
TMEM106B
Genetics of Gene Expression in the Aging Human Brain Reveal TDP-43 Proteinopathy Pathophysiology.
MeSH Terms
- Aged
- Aged, 80 and over
- Aging
- Alzheimer Disease
- Amyloid beta-Peptides
- Apolipoproteins E
- Brain
- Cohort Studies
- DNA-Binding Proteins
- Female
- Gene Expression Regulation
- Haplotypes
- Humans
- Lysosomes
- Male
- Membrane Proteins
- Myelin Sheath
- Nerve Tissue Proteins
- Progranulins
- Quantitative Trait Loci
- RNA Splicing Factors
- TDP-43 Proteinopathies
Keywords
- Alzheimer's disease
- Amyloid-β
- GRN
- RBFOX1
- TDP-43
- TMEM106B
- co-expression module
- cognitive resilience
- eQTL
- expression quantitative trait loci
- sQTL
- splicing quantitative trait loci
TMPRSS2
Susceptibility to COVID-19 in populations with health disparities: Posited involvement of mitochondrial disorder, socioeconomic stress, and pollutants.
Expression of the SARS-CoV-2 Entry Proteins, ACE2 and TMPRSS2, in Cells of the Olfactory Epithelium: Identification of Cell Types and Trends with Age.
MeSH Terms
- Age Factors
- Angiotensin-Converting Enzyme 2
- Animals
- Betacoronavirus
- COVID-19
- Coronavirus Infections
- Gene Expression
- Gene Expression Profiling
- Immunohistochemistry
- In Situ Hybridization
- Mice
- Olfaction Disorders
- Olfactory Mucosa
- Olfactory Receptor Neurons
- Pandemics
- Peptidyl-Dipeptidase A
- Pneumonia, Viral
- RNA-Seq
- Reverse Transcriptase Polymerase Chain Reaction
- SARS-CoV-2
- Serine Endopeptidases
- Virus Internalization
Keywords
- ACE2 expression
- COVID-19
- SARS-CoV-2
- aging
- anosmia
- olfactory epithelium
TNC
Effects of Tenascin C on the Integrity of Extracellular Matrix and Skin Aging.
Tenascin-C expression controls the maturation of articular cartilage in mice.
Effects of hydrothermal aging, thermal cycling, and water storage on the mechanical properties of a machinable resin-based composite containing nano-zirconia fillers.
TNF
Naringenin alleviates nonalcoholic steatohepatitis in middle-aged Apoe mice: role of SIRT1.
Protective role of microglial HO-1 blockade in aging: Implication of iron metabolism.
Anti-aging effect of DL-β-hydroxybutyrate against hepatic cellular senescence induced by D-galactose or γ-irradiation via autophagic flux stimulation in male rats.
Exploring the extensive crosstalk between the antagonistic cytokines- TGF-β and TNF-α in regulating cancer pathogenesis.
Long non-coding RNA SNHG29 regulates cell senescence via p53/p21 signaling in spontaneous preterm birth.
Cognition Is Associated With Peripheral Immune Molecules in Healthy Older Adults: A Cross-Sectional Study.
Anti-aging effects of [i]Ribes meyeri[/i] anthocyanins on neural stem cells and aging mice.
Effects of a four week detraining period on physical, metabolic, and inflammatory profiles of elderly women who regularly participate in a program of strength training.
Contribution of Porphyromonas gingivalis lipopolysaccharide to experimental periodontitis in relation to aging.
New MoDC-Targeting TNF Fusion Proteins Enhance Cyclic Di-GMP Vaccine Adjuvanticity in Middle-Aged and Aged Mice.
Cognitive impairment in elderly patients with rheumatic disease and the effect of disease-modifying anti-rheumatic drugs.
Cotinine ameliorates memory and learning impairment in senescent mice.
Kynurenines link chronic inflammation to functional decline and physical frailty.
Voluntary exercise training attenuated the middle-aged maturity-induced cardiac apoptosis.
Preclinical Evaluation of a Food-Derived Functional Ingredient to Address Skeletal Muscle Atrophy.
Childhood survivors of high-risk neuroblastoma show signs of immune recovery and not immunosenescence.
FK506 induces lung lymphatic endothelial cell senescence and downregulates LYVE-1 expression, with associated decreased hyaluronan uptake.
Late-onset hypogonadism: Reductio ad absurdum of the cardiovascular risk-benefit of testosterone replacement therapy.
Doxorubicin generates senescent microglia that exhibit altered proteomes, higher levels of cytokine secretion, and a decreased ability to internalize amyloid β.
Time restricted feeding provides a viable alternative to alternate day fasting when evaluated in terms of redox homeostasis in rats.
Associations Between Plasma Immunomodulatory and Inflammatory Mediators With VACS Index Scores Among Older HIV-Infected Adults on Antiretroviral Therapy.
Chrysin Impact on Oxidative and Inflammation Damages in the Liver of Aged Male Rats.
Correction of immunosuppression in aged septic rats by human ghrelin and growth hormone through the vagus nerve-dependent inhibition of TGF-β production.
Epigenetics of neuroinflammation: Immune response, inflammatory response and cholinergic synaptic involvement evidenced by genome-wide DNA methylation analysis of delirious inpatients.
[i]Andrographis paniculata[/i] and Its Bioactive Diterpenoids Against Inflammation and Oxidative Stress in Keratinocytes.
Etanercept improves aging-induced cognitive deficits by reducing inflammation and vascular dysfunction in rats.
Bacterial antigen translocation and age as BMI-independent contributing factors on systemic inflammation in NAFLD patients.
Bone marrow mesenchymal stem cells improve thymus and spleen function of aging rats through affecting P21/PCNA and suppressing oxidative stress.
Glycolic acid adjusted to pH 4 stimulates collagen production and epidermal renewal without affecting levels of proinflammatory TNF-alpha in human skin explants.
A20 of nucleus pulposus cells plays a self-protection role via the nuclear factor-kappa B pathway in the inflammatory microenvironment.
Age-associated decline in neural, endocrine, and immune responses in men and women: Involvement of intracellular signaling pathways.
Classical and lectin complement pathways and markers of inflammation for investigation of susceptibility to infections among healthy older adults.
Activation of FoxO1/SIRT1/RANKL/OPG pathway may underlie the therapeutic effects of resveratrol on aging-dependent male osteoporosis.
The senescence-associated secretome as an indicator of age and medical risk.
Exercise Partially Rejuvenates Muscle Stem Cells.
Brazilian berry extract (Myrciaria jaboticaba): A promising therapy to minimize prostatic inflammation and oxidative stress.
MeSH Terms
- Age Factors
- Animals
- Anti-Inflammatory Agents
- Antioxidants
- Cyclooxygenase 2
- Diet, High-Fat
- Dose-Response Relationship, Drug
- Fruit
- Interleukin-1beta
- Interleukin-6
- Lipid Peroxidation
- Male
- Mice
- Myrtaceae
- Oxidative Stress
- Plant Extracts
- Prostatitis
- T-Lymphocytes
Keywords
- aging
- bioactive compounds
- obesity
- overweight
- polyphenols
Potential therapeutic effects of endothelial cells trans-differentiated from Wharton's Jelly-derived mesenchymal stem cells on altered vascular functions in aged diabetic rat model.
[Effect of fragmented sleep on postoperative cognitive function and central neuroinflammation].
Can blocking inflammation enhance immunity during aging?
[FAS- and TNF-dependent ways participation in apoptosis mechanisms in hypotalumus in physiological and pathological aging.]
MeSH Terms
- Aging
- Animals
- Apoptosis
- Female
- Hypothalamus
- Mice
- Mice, Transgenic
- Signal Transduction
- Tumor Necrosis Factor-alpha
- fas Receptor
Keywords
- FAS-, TNF-dependent pathways
- aging
- apoptosis
- hypothalamus
- neurons
Ultrasound-guided continuous thoracic paravertebral block alleviates postoperative delirium in elderly patients undergoing esophagectomy: A randomized controlled trial.
17β-Estradiol improves insulin signalling and insulin resistance in the aged female hearts: Role of inflammatory and anti-inflammatory cytokines.
Synergistic Antitumor Efficacy of Magnetohyperthermia and Poly(lactic-co-glycolic acid)-Encapsulated Selol in Ehrlich Breast Adenocarcinoma Treatment in Elderly Swiss Mice.
Pinitol suppresses TNF-α-induced chondrocyte senescence.
[Aging of skin fibroblasts: genetic and epigenetic factors.]
MeSH Terms
- Cells, Cultured
- Epigenesis, Genetic
- Fibroblasts
- Humans
- Skin Aging
Keywords
- aging
- melatonin
- signal molecules
- skin fibroblasts
Functional and traditional training improve muscle power and reduce proinflammatory cytokines in older women: A randomized controlled trial.
3D TECA hydrogel reduces cellular senescence and enhances fibroblasts migration in wound healing.
Regulatory Effect of Anwulignan on the Immune Function Through Its Antioxidation and Anti-Apoptosis in D-Galactose-Induced Aging Mice.
Pretreatment Frailty Is Independently Associated With Increased Risk of Infections After Immunosuppression in Patients With Inflammatory Bowel Diseases.
The Citrus Flavonoid Naringenin Protects the Myocardium from Ageing-Dependent Dysfunction: Potential Role of SIRT1.
In the Absence of a TCR Signal IL-2/IL-12/18-Stimulated γδ T Cells Demonstrate Potent Anti-Tumoral Function Through Direct Killing and Senescence Induction in Cancer Cells.
Aging is associated with loss of beneficial effects of estrogen on leptin responsiveness in mice fed high fat diet: Role of estrogen receptor α and cytokines.
Mitochondrial Dysfunction and Alpha-Lipoic Acid: Beneficial or Harmful in Alzheimer's Disease?
Design, synthesis and evaluation of diosgenin carbamate derivatives as multitarget anti-Alzheimer's disease agents.
MeSH Terms
- Aging
- Alzheimer Disease
- Amyloid beta-Peptides
- Animals
- Anti-Inflammatory Agents, Non-Steroidal
- Astrocytes
- Carbamates
- Cell Line, Tumor
- Cell Survival
- Diosgenin
- Dose-Response Relationship, Drug
- Drug Design
- Galactose
- Humans
- Inflammation
- Male
- Mice
- Mice, Inbred ICR
- Molecular Structure
- Neuroprotective Agents
- Oxidative Stress
- Protein Aggregates
- Structure-Activity Relationship
Keywords
- Alzheimer’s disease
- Anti-Aβ activity
- Anti-inflammatory
- Antioxidant
- Diosgenin
- Multi-target-directed ligands
Oral Administration of Okara Soybean By-Product Attenuates Cognitive Impairment in a Mouse Model of Accelerated Aging.
Electric vagal nerve stimulation inhibits inflammation and improves early postoperation cognitive dysfunction in aged rats.
MeSH Terms
- Aging
- Anesthesia, General
- Animals
- Behavior, Animal
- Hippocampus
- Inflammation
- Male
- Maze Learning
- NF-kappa B
- Postoperative Cognitive Complications
- Rats
- Rats, Sprague-Dawley
- Splenectomy
- Tumor Necrosis Factor-alpha
- Vagus Nerve Stimulation
Keywords
- Cognitive dysfunction
- General anesthesia
- Inflammation
- Vagus nerve stimulation
Metformin decreases LPS-induced inflammatory response in rabbit annulus fibrosus stem/progenitor cells by blocking HMGB1 release.
MeSH Terms
- Animals
- Annulus Fibrosus
- Anti-Inflammatory Agents
- Cellular Senescence
- HMGB1 Protein
- Inflammation
- Intervertebral Disc Degeneration
- Lipopolysaccharides
- Metformin
- Rabbits
- Stem Cells
Keywords
- HMGB1
- annulus fibrosis stem cells
- cell senescence
- intervertebral disc degeneration
- metformin
The effects of blueberry and strawberry serum metabolites on age-related oxidative and inflammatory signaling in vitro.
Arsenic induces human chondrocyte senescence and accelerates rat articular cartilage aging.
Bone Benefits of Fish Oil Supplementation Depend on its EPA and DHA Content.
MeSH Terms
- Age Factors
- Animals
- Bone Density
- Bone Density Conservation Agents
- Bone Marrow Cells
- Bone Remodeling
- Bone and Bones
- Cells, Cultured
- Cytokines
- Dietary Supplements
- Disease Models, Animal
- Docosahexaenoic Acids
- Eicosapentaenoic Acid
- Female
- JNK Mitogen-Activated Protein Kinases
- Mice, Inbred C57BL
- Osteoporosis
- Signal Transduction
- p38 Mitogen-Activated Protein Kinases
Keywords
- aging
- bone mineral density
- bone resorption
- concentrated fish oil
- cytokines
- inflammation
- omega-3 fatty acids
Inflammaging phenotype in rhesus macaques is associated with a decline in epithelial barrier-protective functions and increased pro-inflammatory function in CD161-expressing cells.
Single-cell transcriptomics reveals expansion of cytotoxic CD4 T cells in supercentenarians.
MeSH Terms
- Adult
- Aged
- Aged, 80 and over
- B-Lymphocytes
- CD4-Positive T-Lymphocytes
- Case-Control Studies
- Cell Differentiation
- Cells, Cultured
- Clonal Evolution
- Gene Expression Profiling
- Humans
- Interferon-gamma
- Leukocytes, Mononuclear
- Middle Aged
- Single-Cell Analysis
- Tumor Necrosis Factor-alpha
Keywords
- CD4 CTL
- aging
- centenarian
- single-cell transcriptome
Gut microbiota combined with metabolomics reveals the metabolic profile of the normal aging process and the anti-aging effect of FuFang Zhenshu TiaoZhi(FTZ) in mice.
Intervertebral disc ageing and degeneration: The antiapoptotic effect of oestrogen.
MeSH Terms
- Aging
- Animals
- Apoptosis
- Cytokines
- Estrogens
- Female
- Humans
- Inflammation
- Intervertebral Disc
- Intervertebral Disc Degeneration
- Intervertebral Disc Displacement
- Male
- Phosphatidylinositol 3-Kinases
- Signal Transduction
Keywords
- Ageing
- Apoptosis
- Intervertebral disc degeneration
- Oestrogen
- Spine
MicroRNA 16-5p is upregulated in calorie-restricted mice and modulates inflammatory cytokines of macrophages.
MeSH Terms
- Aging
- Animals
- Caloric Restriction
- Cytokines
- Diet Therapy
- Inflammation
- Interleukin-1beta
- Macrophages
- Male
- Mice
- Mice, Inbred C57BL
- MicroRNAs
- Models, Animal
- RAW 264.7 Cells
- Transcriptional Activation
- Tumor Necrosis Factor-alpha
- Up-Regulation
Keywords
- Caloric restriction
- Cellular immunology
- Cytokines
- Macrophages
- microRNA
Aerobic exercise modulates cytokine profile and sleep quality in elderly.
Trehalose targets Nrf2 signal to alleviate d-galactose induced aging and improve behavioral ability.
Anti-Inflammatory and Anti-Aging Evaluation of Pigment-Protein Complex Extracted from [i]Chlorella Pyrenoidosa[/i].
MeSH Terms
- Aging
- Animals
- Anti-Inflammatory Agents
- Antioxidants
- Biological Products
- Chlorella
- Cytokines
- Disease Models, Animal
- Galactose
- Inflammation
- Interleukin-6
- Lipopolysaccharides
- Macrophages
- Male
- Mice
- Mice, Inbred C57BL
- NF-kappa B
- Nitric Oxide
- Oxidative Stress
- RAW 264.7 Cells
- Superoxide Dismutase
- Tumor Necrosis Factor-alpha
Keywords
- Chlorella pyrenoidosa
- NF-κB
- PPARs
- anti-aging
- anti-inflammation
- pigment–protein complex
Inflammatory mediators and the risk of falls among older women with acute low back pain: data from Back Complaints in the Elders (BACE)-Brazil.
Acetylcholinesterase inhibitors targeting the cholinergic anti-inflammatory pathway: a new therapeutic perspective in aging-related disorders.
Study on Metabolic Trajectory of Liver Aging and the Effect of Fufang Zhenzhu Tiaozhi on Aging Mice.
Systemic Tumor Necrosis Factor-Alpha Trajectories Relate to Brain Health in Typically Aging Older Adults.
Targeting senescence improves angiogenic potential of adipose-derived mesenchymal stem cells in patients with preeclampsia.
MeSH Terms
- Adipose Tissue
- Adult
- Cell Movement
- Cell Proliferation
- Cell Survival
- Cellular Senescence
- Dasatinib
- Female
- Humans
- Mesenchymal Stem Cells
- Pre-Eclampsia
- Pregnancy
- Protein Kinase Inhibitors
Keywords
- Angiogenesis, Senolytics, Dasatinib
- Mesenchymal stem cells
- Preeclampsia
- Senescence
Suppression of gut dysbiosis by Bifidobacterium longum alleviates cognitive decline in 5XFAD transgenic and aged mice.
Moderate hyperoxia induces senescence in developing human lung fibroblasts.
MeSH Terms
- Autophagy
- CCAAT-Enhancer-Binding Protein-beta
- Cell Proliferation
- Cellular Senescence
- Cyclin-Dependent Kinase Inhibitor p21
- DNA Damage
- Endoplasmic Reticulum Stress
- Etoposide
- Extracellular Matrix
- Fetus
- Fibroblasts
- G2 Phase Cell Cycle Checkpoints
- Gene Expression Regulation
- Humans
- Hyperoxia
- Interleukin-1
- Interleukin-8
- Lung
- Matrix Metalloproteinase 3
- Oxygen
- Plasminogen Activator Inhibitor 1
- Primary Cell Culture
- Tumor Necrosis Factor-alpha
- Tumor Suppressor Protein p53
Keywords
- autophagy
- endoplasmic reticulum stress
- lung development
- oxygen
- senescence
Aging-related carcinoembryonic antigen-related cell adhesion molecule 1 signaling promotes vascular dysfunction.
Microglia Express Insulin-Like Growth Factor-1 in the Hippocampus of Aged APP /PS1 Transgenic Mice.
Age- and diet-specific effects of chronic exposure to chlorpyrifos on hormones, inflammation and gut microbiota in rats.
MeSH Terms
- Aging
- Animals
- Chlorpyrifos
- Diet, High-Fat
- Gastrointestinal Microbiome
- Hypothalamo-Hypophyseal System
- Inflammation
- Male
- Pituitary-Adrenal System
- RNA, Ribosomal, 16S
- Rats
Keywords
- 16S rRNA gene sequencing
- Gut endocrine
- Gut-brain axis
- Hormone
- Hypothalamic-pituitary-adrenal axis
- Inflammation
TOMM20
Effect of aging on mitochondria and metabolism of bovine granulosa cells.
TP53
p53 inhibits the osteogenic differentiation but does not induce senescence in human dental follicle cells.
Mutational spectrum and dynamics of clonal hematopoiesis in anemia of older individuals.
TP53/miR-34a-associated signaling targets [i]SERPINE1[/i] expression in human pancreatic cancer.
Expression of p16 in nodular fasciitis: an implication for self-limited and inflammatory nature of the lesion.
TPH1
[i]Lactobacillus plantarum[/i] DR7 improved brain health in aging rats via the serotonin, inflammatory and apoptosis pathways.
TPO
Megakaryocytes promote osteoclastogenesis in aging.
TPP1
FBW7 Mediates Senescence and Pulmonary Fibrosis through Telomere Uncapping.
TPR
Catalytic Performances of Cu/MCM-22 Zeolites with Different Cu Loadings in NH -SCR.
Do traits of plant species predict the efficacy of species distribution models for finding new occurrences?
In-situ modified the surface of Pt-doped perovskite catalyst for soot oxidation.
TRAF3
TRAF3, a Target of MicroRNA-363-3p, Suppresses Senescence and Regulates the Balance Between Osteoblastic and Adipocytic Differentiation of Rat Bone Marrow-Derived Mesenchymal Stem Cells.
TREM2
Loss of TREM2 Confers Resilience to Synaptic and Cognitive Impairment in Aged Mice.
Triggering Receptor Expressed on Myeloid Cell 2 R47H Exacerbates Immune Response in Alzheimer's Disease Brain.
Knockdown of astrocytic TREM2 in the hippocampus relieves cognitive decline in elderly male mice.
TRIM21
TRIM21 overexpression promotes tumor progression by regulating cell proliferation, cell migration and cell senescence in human glioma.
TRIM27
TRIM27 Functions as a Novel Oncogene in Non-Triple-Negative Breast Cancer by Blocking Cellular Senescence through p21 Ubiquitination.
TRIP13
BubR1 allelic effects drive phenotypic heterogeneity in mosaic-variegated aneuploidy progeria syndrome.
TRPC6
Redox and mTOR-dependent regulation of plasma lamellar calcium influx controls the senescence-associated secretory phenotype.
TRPC7
Nociceptive transient receptor potential canonical 7 (TRPC7) mediates aging-associated tumorigenesis induced by ultraviolet B.
TRPV4
TRPV4 receptor as a functional sensory molecule in bladder urothelium: Stretch-independent, tissue-specific actions and pathological implications.
Exercise restores impaired endothelium-derived hyperpolarizing factor-mediated vasodilation in aged rat aortic arteries via the TRPV4-K 2.3 signaling complex.
TSPO
Age and Sex Influence the Neuro-inflammatory Response to a Peripheral Acute LPS Challenge.
Upregulation of cannabinoid receptor type 2, but not TSPO, in senescence-accelerated neuroinflammation in mice: a positron emission tomography study.
MeSH Terms
- Aging
- Animals
- Brain
- Inflammation
- Mice
- Microglia
- Positron-Emission Tomography
- Radiopharmaceuticals
- Receptor, Cannabinoid, CB2
- Receptors, GABA
- Up-Regulation
Keywords
- Cannabinoid receptor type 2
- Immunostaining
- Microglial activation
- Positron emission tomography
- Senescence-accelerated prone mouse
- Translocator protein
TST
H S Donors Reverse Age-Related Gastric Malfunction Impaired Due to Fructose-Induced Injury [i]via[/i] CBS, CSE, and TST Expression.
Adaptations in mechanical muscle function, muscle morphology, and aerobic power to high-intensity endurance training combined with either traditional or power strength training in older adults: a randomized clinical trial.
Digital phenotyping by consumer wearables identifies sleep-associated markers of cardiovascular disease risk and biological aging.
Objective Sleep Duration in Older Adults: Results From The Irish Longitudinal Study on Ageing.
TTL
Longitudinal Associations of Body Mass Index, Waist Circumference, and Waist-to-Hip Ratio with Biomarkers of Oxidative Stress in Older Adults: Results of a Large Cohort Study.
MeSH Terms
- Aged
- Aged, 80 and over
- Aging
- Biomarkers
- Body Mass Index
- Cohort Studies
- Female
- Germany
- Humans
- Longitudinal Studies
- Male
- Middle Aged
- Oxidative Stress
- Waist Circumference
- Waist-Hip Ratio
Keywords
- Body mass index
- Free radicals
- Oxidative stress
- Reactive oxygen metabolites
- Total thiol levels
- Waist circumference
- Waist-to-hip ratio
TTN
LncRNA TTN-AS1 regulates osteosarcoma cell apoptosis and drug resistance via the miR-134-5p/MBTD1 axis.
MeSH Terms
- Aging
- Apoptosis
- Brain Neoplasms
- Cell Line, Tumor
- Cell Proliferation
- Chromosomal Proteins, Non-Histone
- Computational Biology
- Drug Resistance
- Gene Expression Regulation, Neoplastic
- Humans
- MicroRNAs
- Osteosarcoma
- RNA, Long Noncoding
Keywords
- aging and age-related diseases
- lncRNA TTN-AS1
- malignant brain tumour domain containing protein 1
- miR-134-5p
- osteosarcoma
- resistance
TTR
Cellular secretion and cytotoxicity of transthyretin mutant proteins underlie late-onset amyloidosis and neurodegeneration.
MeSH Terms
- Amyloid Neuropathies, Familial
- Animals
- Cell Death
- Cell Line, Tumor
- Disease Models, Animal
- Drosophila
- HEK293 Cells
- Humans
- Locomotion
- Longevity
- Mutant Proteins
- Mutation
- Nerve Degeneration
- Prealbumin
Keywords
- Amyloidosis
- Drosophila melanogaster
- ERQC
- Endoplasmic reticulum quality control
- Proteostasis
- TTR
- Transthyretin
TXNIP
Panax notoginseng saponins attenuate neuroinflammation through TXNIP-mediated NLRP3 inflammasome activation in aging rats.
Redox homeostasis and cell cycle activation mediate beta-cell mass expansion in aged, diabetes-prone mice under metabolic stress conditions: Role of thioredoxin-interacting protein (TXNIP).
[Effect of diabetic induced thioredoxin interacting protein (TXNIP) on islet cell senescence].
PRMT5-TRIM21 interaction regulates the senescence of osteosarcoma cells by targeting the TXNIP/p21 axis.
TXNRD2
Wogonin induces cellular senescence in breast cancer via suppressing TXNRD2 expression.
U2AF1
Isobaric tags for relative and absolute quantitation (iTRAQ)-based proteomic analysis of mRNA splicing relevant proteins in aging HSPCs.
UACA
Knockdown of [i]UACA[/i] inhibitsproliferation and invasion and promotes senescence of hepatocellular carcinoma cells.
UCHL1
Abolishing UCHL1's hydrolase activity exacerbates TBI-induced axonal injury and neuronal death in mice.
UCP1
Muscle-dependent regulation of adipose tissue function in long-lived growth hormone-mutant mice.
Postnatal leptin surge is critical for the transient induction of the developmental beige adipocytes in mice.
Age-related sex differences in the expression of important disease-linked mitochondrial proteins in mice.
An anti-inflammatory phenotype in visceral adipose tissue of old lean mice, augmented by exercise.
UGT2B28
Ages of hepatocellular carcinoma occurrence and life expectancy are associated with a UGT2B28 genomic variation.
MeSH Terms
- Adult
- Age of Onset
- Aged
- Aged, 80 and over
- Carcinoma, Hepatocellular
- Female
- Genetic Association Studies
- Genetic Predisposition to Disease
- Glucuronosyltransferase
- Humans
- Life Expectancy
- Liver Neoplasms
- Male
- Middle Aged
- Neoplasm Metastasis
- Neoplasm Recurrence, Local
- Odds Ratio
- Polymorphism, Single Nucleotide
- Survival Analysis
- Young Adult
Keywords
- Alcoholism
- Xenobiotic metabolizing enzymes
- Young hepatocellular carcinoma; age of death
USP7
Deubiquitinase USP7 regulates [i]Drosophila[/i] aging through ubiquitination and autophagy.
VCAM1
Sunitinib facilitates metastatic breast cancer spreading by inducing endothelial cell senescence.
VDAC1
Low abundance of NDUFV2 and NDUFS4 subunits of the hydrophilic complex I domain and VDAC1 predicts mammalian longevity.
Changes in the expression of oxidative phosphorylation complexes in the aging intestinal mucosa.
VDR
25-Hydroxyvitamin D positively regulates periodontal inflammaging via SOCS3/STAT signaling in diabetic mice.
1,25-Dihydroxyvitamin D protects against age-related osteoporosis by a novel VDR-Ezh2-p16 signal axis.
MeSH Terms
- 25-Hydroxyvitamin D3 1-alpha-Hydroxylase
- Aging
- Animals
- Bone and Bones
- Cells, Cultured
- Cyclin-Dependent Kinase Inhibitor p16
- Cyclin-Dependent Kinase Inhibitor p19
- DNA Damage
- Enhancer of Zeste Homolog 2 Protein
- Female
- Histones
- Male
- Mesenchymal Stem Cells
- Mice
- Mice, Knockout
- Osteocytes
- Osteogenesis
- Osteoporosis
- Oxidative Stress
- Receptors, Calcitriol
- Vitamin D
Keywords
- Ezh2
- Vitamin D
- cellular senescence
- osteogenesis
- osteoporosis
- p16
Active vitamin D impedes the progression of non-alcoholic fatty liver disease by inhibiting cell senescence in a rat model.
VEGFA
APOE ε4-specific associations of VEGF gene family expression with cognitive aging and Alzheimer's disease.
MeSH Terms
- Aged
- Aged, 80 and over
- Aging
- Apolipoprotein E4
- Cognitive Aging
- Cognitive Dysfunction
- Female
- Gene Expression
- Genetic Association Studies
- Genetic Predisposition to Disease
- Genotype
- Humans
- Male
- Neovascularization, Physiologic
- Neuropilin-1
- Vascular Endothelial Growth Factor A
Keywords
- APOE-ε4
- Aging
- Cognition
- Gene expression
- Vascular endothelial growth factor (VEGF)
VGLL4
The lncRNA MEG3/miR-16-5p/VGLL4 regulatory axis is involved in etoposide-induced senescence of tumor cells.
VHL
Hypoxic response regulators RHY-1 and EGL-9/PHD promote longevity through a VHL-1-independent transcriptional response.
VIM
Establishment and characterization of a fibroblast cell line from postmortem skin of an adult Chinese muntjac (Muntiacus reevesi).
VIP
Alterations in Intrinsic and Synaptic Properties of Hippocampal CA1 VIP Interneurons During Aging.
Nutrition and exercise interventions could ameliorate age-related cognitive decline: a meta-analysis of randomized controlled trials.
VSIG4
Immune checkpoint protein VSIG4 as a biomarker of aging in murine adipose tissue.
WASL
Loss of Wasl improves pancreatic cancer outcome.
WDR5
Inhibition of the H3K4 methyltransferase MLL1/WDR5 complex attenuates renal senescence in ischemia reperfusion mice by reduction of p16 .
MeSH Terms
- Acute Kidney Injury
- Animals
- Biphenyl Compounds
- Cell Line
- Cyclin-Dependent Kinase Inhibitor p16
- Dihydropyridines
- Drug Evaluation, Preclinical
- Fibroblasts
- Histone-Lysine N-Methyltransferase
- Histones
- Intracellular Signaling Peptides and Proteins
- Male
- Mice, Inbred C57BL
- Myeloid-Lymphoid Leukemia Protein
- Rats
- Renal Insufficiency
- Reperfusion Injury
Keywords
- H3K4me3
- MLL1
- WDR5
- acute kidney injury
- p16(INK4a)
- senescence
WFDC2
Differences in biomarkers and molecular pathways according to age for patients with HFrEF.
WIPI2
Neuronal autophagy declines substantially with age and is rescued by overexpression of WIPI2.
WNT1
Plasma proteomic profile of age, health span, and all-cause mortality in older adults.
WNT10A
Dysregulation of the Wnt Signaling Pathway and Synovial Stem Cell Dysfunction in Osteoarthritis Development.
WNT3A
Chronic WNT/β-catenin signaling induces cellular senescence in lung epithelial cells.
WNT7A
Exogenous Expression of WNT7A in Leukemia-Derived Cell Lines Induces Resistance to Chemotherapeutic Agents.
WRN
The Impact of Vitamin C on Different System Models of Werner Syndrome.
WRN modulates translation by influencing nuclear mRNA export in HeLa cancer cells.
MIB1-mediated degradation of WRN promotes cellular senescence in response to camptothecin treatment.
A Case Report of Werner's Syndrome With a Novel Mutation From India.
Evidence for premature aging in a Drosophila model of Werner syndrome.
MeSH Terms
- Aging, Premature
- Animals
- Behavior, Animal
- Body Composition
- Body Weight
- DNA Repair
- Drosophila
- Drosophila Proteins
- Exonucleases
- Female
- Gastrointestinal Neoplasms
- Male
- Motor Activity
- Muscle Weakness
- Mutation
- Phenotype
- Werner Syndrome
Keywords
- Aging
- DNA repair
- Locomotor function
- Tumor
- Werner syndrome
WT1
Age and weight at first mating affects plasma leptin concentration but no effects on reproductive performance of gilts.
WWP1
The ubiquitin ligase WWP1 contributes to shifts in matrix proteolytic profiles and a myocardial aging phenotype with diastolic heart.
MeSH Terms
- Age Factors
- Animals
- Cells, Cultured
- Diastole
- Disease Models, Animal
- Extracellular Matrix
- Female
- Fibroblasts
- Heart Failure
- Hypertrophy, Left Ventricular
- Male
- Mice, Inbred C57BL
- Mice, Transgenic
- Myocardium
- Phenotype
- Proteolysis
- Stroke Volume
- Ubiquitin-Protein Ligases
- Ventricular Dysfunction, Left
- Ventricular Function, Left
- Ventricular Remodeling
Keywords
- aging
- cardiac hypertrophy
- diastolic dysfunction
- heart failure
- ventricular remodeling
XBP1
Age-dependent impairment of adipose-derived stem cells isolated from horses.
XDH
Enhancing xanthine dehydrogenase activity is an effective way to delay leaf senescence and increase rice yield.
ZC3H12A
Keratinocyte-specific ablation of Mcpip1 impairs skin integrity and promotes local and systemic inflammation.
MeSH Terms
- Aging
- Animals
- Calgranulin A
- Cell Differentiation
- Cell Proliferation
- Cells, Cultured
- Cornified Envelope Proline-Rich Proteins
- Epidermis
- Gene Expression Regulation
- Gene Ontology
- Inflammation
- Interleukin-1
- Keratinocytes
- Keratins
- Lymph Nodes
- Mice
- Mice, Inbred C57BL
- Mice, Transgenic
- Proliferating Cell Nuclear Antigen
- Ribonucleases
- Skin
- Spleen
- Transcriptome
Keywords
- MCPIP1
- Regnase-1
- Skin inflammation
- ZC3H12A
ZEB2
miR-200b regulates cellular senescence and inflammatory responses by targeting ZEB2 in pulmonary emphysema.
ZMPSTE24
Bone marrow-derived mesenchymal stem cells in three-dimensional co-culture attenuate degeneration of nucleus pulposus cells.
MeSH Terms
- Bone Marrow Cells
- Cell Cycle
- Cell Proliferation
- Cell Survival
- Cells, Cultured
- Cellular Senescence
- Coculture Techniques
- Collagen Type II
- Female
- Humans
- Intervertebral Disc Degeneration
- Male
- Matrix Metalloproteinase 9
- Membrane Proteins
- Mesenchymal Stem Cells
- Metalloendopeptidases
- Middle Aged
- Nucleus Pulposus
- Signal Transduction
- Transcription Factor RelA
- Up-Regulation
- beta-Galactosidase
Keywords
- 3D co-culture
- ZMPSTE24
- bone marrow-derived mesenchymal stem cells
- nucleus pulposus
- senescence