FEV

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Protein FEV (Fifth Ewing variant protein) (PC12 ETS domain-containing transcription factor 1) (PC12 ETS factor 1) (Pet-1) [PET1]

Publications[править]

Prediction of Lung Function in Adolescence Using Epigenetic Aging: A Machine Learning Approach.


Effect of Age on the Efficacy and Safety of Once-Daily Single-Inhaler Triple Therapy Fluticasone Furoate/Umeclidinium/Vilanterol in Patients With Chronic Obstructive Pulmonary Disease: A Post Hoc Analysis of the IMPACT Trial.


A comprehensive analysis of factors related to lung function in older adults: Cross-sectional findings from the Canadian Longitudinal Study on Aging.


Cigarette smoke induction of S100A9 contributes to chronic obstructive pulmonary disease.


Risk factors associated with the detection of pulmonary emphysema in older asymptomatic respiratory subjects.


Tiotropium Respimat Efficacy and Safety in Asthma: Relationship to Age.


Current Bronchodilator Responsiveness Criteria Underestimate Asthma in Older Adults.


Physical performances show conflicting associations in aged manual workers.


FEV as a Standalone Spirometric Predictor and the Attributable Fraction for Death in Older Persons.


An Individualized Prediction Model for Long-term Lung Function Trajectory and Risk of COPD in the General Population.


Telomere length and lung function in a population-based cohort of children and mid-life adults.


Rate of normal lung function decline in ageing adults: a systematic review of prospective cohort studies.


The moderating effect of childhood disadvantage on the associations between smoking and occupational exposure and lung function; a cross sectional analysis of the UK Household Longitudinal Study (UKHLS).


Occupational exposure to solvents and lung function decline: A population based study.


Disease-Specific Comorbidity Clusters in COPD and Accelerated Aging.


The Effect of the Stretch-Shortening Cycle in the Force-Velocity Relationship and Its Association With Physical Function in Older Adults With COPD.


Socioeconomic status and pulmonary function, transition from childhood to adulthood: cross-sectional results from the polish part of the HAPIEE study.


Benefits of improved air quality on ageing lungs: impacts of genetics and obesity.


The Effects of Aging on Exhaled Nitric Oxide (FeNO) in a North African Population.


Exogenous female sex steroids may reduce lung ageing after menopause: A 20-year follow-up study of a general population sample (ECRHS).


Metastable DNA methylation sites associated with longitudinal lung function decline and aging in humans: an epigenome-wide study in the NAS and KORA cohorts.

{{medline-entry |title=Contribution of peripheral airway function to changes in FEV /FVC and RV/TLC with aging. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/30138079 |abstract=Multiple breath nitrogen washout (MBNW) indices provide insight into ventilation heterogeneity globally [lung clearance index (LCI)] and within acinar (S ) and conducting (S ) airways. Normal aging leads to an accelerated deterioration of S in older adults, but little is known about the contribution of peripheral airway function to changes in pulmonary function indices reflecting expiratory airflow [forced expiratory volume in one second (FEV )/forced vital capacity (FVC)] and gas trapping [residual volume (RV)/total lung capacity (TLC)] with aging. We aimed to examine associations between MBNW and FEV /FVC as well as RV/TLC in healthy adults, and to determine if these relationships differ in older (≥50 yr) versus younger subjects (<50 yr). Seventy-nine healthy adult volunteers aged 23-89 yr with no cardiac or respiratory disease and a smoking history of <5 pack-years underwent spirometry, plethysmography, and MBNW. After adjustment for sex, height, and body mass index, the following relationships were present across the entire cohort: S was inversely related to FEV /FVC (R  = 0.22, P < 0.001); S and S were positively related to RV/TLC (R  = 0.53, P < 0.001); on separate analyses, the relationship between S and FEV /FVC was strongest in the older group (R  = 0.20, P = 0.003) but markedly weaker in the younger group (R  = 0.09, P = 0.04); and S and S were related to RV/TLC in older (R  = 0.20, P = 0.003) but not younger subgroups. No relationships were observed between LCI and FEV /FVC or RV/TLC. Changes in FEV /FVC and RV/TLC are at least in part due to changes in peripheral airway function with aging. Further studies of the relationships between MBNW and standard pulmonary function indices may prove useful for their combined application and interpretation in obstructive airways disease. NEW