Aging genes 10-29

CCL2

β1 Integrin regulates adult lung alveolar epithelial cell inflammation. / 30.01.2020 / PubMed / Full text
Neuroprotective effects of targeting BET proteins for degradation with dBET1 in aged mice subjected to ischemic stroke. / 07.2019 / PubMed / Full text
Membrane metallo-endopeptidase mediates cellular senescence induced by oncogenic PIK3CA accompanied with pro-tumorigenic secretome. / 01.08.2019 / PubMed / Full text
Isoflurane anesthesia impairs the expression of immune neuromodulators in the hippocampus of aged mice. / 2018 / PubMed / Full text
Melatonin and inflammation-Story of a double-edged blade. / 11.2018 / PubMed / Full text
Defective autophagy in vascular smooth muscle cells enhances cell death and atherosclerosis. / 2018 / PubMed / Full text
Urine Cytokine and Chemokine Levels Predict Urinary Tract Infection Severity Independent of Uropathogen, Urine Bacterial Burden, Host Genetics, and Host Age. / 09.2018 / PubMed / Full text
Infiltrating macrophages contribute to age-related neuroinflammation in C57/BL6 mice. / 07.2018 / PubMed / Full text
Time-Dependent Changes in Local and Serum Levels of Inflammatory Cytokines as Markers for Incised Wound Aging of Skeletal Muscles. / 05.2018 / PubMed / Full text
Age-related pro-inflammatory and pro-angiogenic changes in human aqueous humor. / 2018 / PubMed / Full text
Immune senescence and biomarkers profile of Bambuí aged population-based cohort. / 03.2018 / PubMed / Full text
Selected life-extending interventions reduce arterial CXCL10 and macrophage colony-stimulating factor in aged mouse arteries. / 08.2017 / PubMed / Full text
Strain specificities in cellular and molecular immunopathogenic mechanisms underlying development of experimental autoimmune encephalomyelitis in aged rats. / 06.2017 / PubMed / Full text
Advanced atherosclerosis is associated with inflammation, vascular dysfunction and oxidative stress, but not hypertension. / 02.2017 / PubMed / Full text
An attenuated immune response by Schwann cells and macrophages inhibits nerve regeneration in aged rats. / 09.2016 / PubMed / Full text
Enhanced Ccl2-Ccr2 signaling drives more severe choroidal neovascularization with aging. / 04.2016 / PubMed / Full text
Agmatine Ameliorates High Glucose-Induced Neuronal Cell Senescence by Regulating the p21 and p53 Signaling. / 02.2016 / PubMed / Full text
Alterations in Monocyte Phenotypes and Functions after a Hip Fracture in Elderly Individuals: A 6-Month Longitudinal Study. / 2016 / PubMed / Full text
Elevated Levels of Microbial Translocation Markers and CCL2 Among Older HIV-1-Infected Men. / 01.03.2016 / PubMed / Full text
APOE Isoforms Control Pathogenic Subretinal Inflammation in Age-Related Macular Degeneration. / 07.10.2015 / PubMed / Full text
Colorectal cancer-promoting activity of the senescent peritoneal mesothelium. / 06.10.2015 / PubMed / Full text
Nilotinib and bosutinib modulate pre-plaque alterations of blood immune markers and neuro-inflammation in Alzheimer's disease models. / 24.09.2015 / PubMed / Full text
Neuroimmune and Neuropathic Responses of Spinal Cord and Dorsal Root Ganglia in Middle Age. / 2015 / PubMed / Full text
Microglial Kv1.3 Channels and P2Y12 Receptors Differentially Regulate Cytokine and Chemokine Release from Brain Slices of Young Adult and Aged Mice. / 2015 / PubMed / Full text
CCL2, CXCL8, CXCL9 and CXCL10 serum levels increase with age but are not altered by treatment with hydroxychloroquine in patients with osteoarthritis of the knees. / 12.2017 / PubMed / Full text
Senescent dermal fibroblasts enhance stem cell migration through CCL2/CCR2 axis. / 07.2015 / PubMed / Full text
Age-associated changes in basal NF-κB function in human CD4 T lymphocytes via dysregulation of PI3 kinase. / 11.2014 / PubMed / Full text
IL-4 signaling drives a unique arginase /IL-1β microglia phenotype and recruits macrophages to the inflammatory CNS: consequences of age-related deficits in IL-4Rα after traumatic spinal cord injury. / 25.06.2014 / PubMed / Full text
Systemic inflammation impairs attention and cognitive flexibility but not associative learning in aged rats: possible implications for delirium. / 2014 / PubMed / Full text

EGFR

Type I Collagen Aging Increases Expression and Activation of EGFR and Induces Resistance to Erlotinib in Lung Carcinoma in 3D Matrix Model. / 2020 / PubMed / Full text
Comparative effectiveness and cost-effectiveness of three first-line EGFR-tyrosine kinase inhibitors: Analysis of real-world data in a tertiary hospital in Taiwan. / 2020 / PubMed / Full text
An Optogenetic Method to Study Signal Transduction in Intestinal Stem Cell Homeostasis. / 01.05.2020 / PubMed / Full text
Treatment-Induced Tumor Dormancy through YAP-Mediated Transcriptional Reprogramming of the Apoptotic Pathway. / 13.01.2020 / PubMed / Full text
Association between EGFR mutation and ageing, history of pneumonia and gastroesophageal reflux disease among patients with advanced lung cancer. / 11.2019 / PubMed / Full text
Systems biology and network pharmacology of frailty reveal novel epigenetic targets and mechanisms. / 22.07.2019 / PubMed / Full text
The role of EGFR signaling in age-related osteoporosis in mouse cortical bone. / 10.2019 / PubMed / Full text
Regulation of RhoB Gene Expression during Tumorigenesis and Aging Process and Its Potential Applications in These Processes. / 13.06.2019 / PubMed / Full text
EGF/EGFR upregulates and cooperates with Netrin-4 to protect glioblastoma cells from DNA damage-induced senescence. / 04.12.2018 / PubMed / Full text
An Adult Drosophila Glioma Model for Studying Pathometabolic Pathways of Gliomagenesis. / 06.2019 / PubMed / Full text
Quantum Modeling: A Bridge between the Pumping and Signaling Functions of Na/K-ATPase. / 09.08.2018 / PubMed / Full text
Novel drug-resistance mechanisms of pemetrexed-treated non-small cell lung cancer. / 30.03.2018 / PubMed / Full text
Withanolide A extends the lifespan in human EGFR-driven cancerous Caenorhabditis elegans. / 04.2018 / PubMed / Full text
30 YEARS OF THE MINERALOCORTICOID RECEPTOR: Nongenomic effects via the mineralocorticoid receptor. / 07.2017 / PubMed / Full text
Inverse relationship between Alzheimer's disease and cancer, and other factors contributing to Alzheimer's disease: a systematic review. / 22.11.2016 / PubMed / Full text
Low-frequency [i]KRAS[/i] mutations are prevalent in lung adenocarcinomas. / 03.2015 / PubMed / Full text
Association of Polymorphisms in Connective Tissue Growth Factor and Epidermal Growth Factor Receptor Genes With Human Longevity. / 01.08.2017 / PubMed / Full text
sPLA2 -IIA Overexpression in Mice Epidermis Depletes Hair Follicle Stem Cells and Induces Differentiation Mediated Through Enhanced JNK/c-Jun Activation. / 09.2016 / PubMed / Full text
Mechanisms of skin aging induced by EGFR inhibitors. / 10.2016 / PubMed / Full text
Prolactin, EGFR, vimentin and α-actin profiles in elderly rat prostate subjected to steroid hormonal imbalance. / 06.2016 / PubMed / Full text
Loss of Maspardin Attenuates the Growth and Maturation of Mouse Cortical Neurons. / 2016 / PubMed / Full text
Expression profile analysis of new candidate genes for the therapy of primary osteoporosis. / 2016 / PubMed
Selective coexpression of VEGF receptor 2 in EGFRvIII-positive glioblastoma cells prevents cellular senescence and contributes to their aggressive nature. / 05.2016 / PubMed / Full text
Bradykinin inhibits oxidative stress-induced senescence of endothelial progenitor cells through the B2R/AKT/RB and B2R/EGFR/RB signal pathways. / 22.09.2015 / PubMed / Full text
First-line gefitinib treatment in elderly patients (aged ≥75 years) with non-small cell lung cancer harboring EGFR mutations. / 10.2015 / PubMed / Full text
Increased centrosome amplification in aged stem cells of the Drosophila midgut. / 25.07.2014 / PubMed / Full text
Prospective identification of functionally distinct stem cells and neurosphere-initiating cells in adult mouse forebrain. / 07.05.2014 / PubMed / Full text
Thiamin concentration in geriatric hospitalized patients using frusemide. / 2014 / PubMed / Full text
4-Hydroxynonenal impairs transforming growth factor-β1-induced elastin synthesis via epidermal growth factor receptor activation in human and murine fibroblasts. / 06.2014 / PubMed / Full text

LBP

Lipopolysaccharide binding protein is associated with CVD risk in older adults. / 08.09.2020 / PubMed / Full text
Aging-related liver degeneration is associated with increased bacterial endotoxin and lipopolysaccharide binding protein levels. / 01.04.2020 / PubMed / Full text
Biomarkers of leaky gut are related to inflammation and reduced physical function in older adults with cardiometabolic disease and mobility limitations. / 12.2019 / PubMed / Full text
Needle-shaped amyloid deposition in rat mammary gland: evidence of a novel amyloid fibril protein. / 03.2020 / PubMed / Full text
Effects of Lycium barbarum Polysaccharides on Health and Aging of [i]C. elegans[/i] Depend on [i]daf-12/daf-16[/i]. / 2019 / PubMed / Full text
Structural characterization of life-extending Caenorhabditis elegans Lipid Binding Protein 8. / 10.07.2019 / PubMed / Full text
Lycium barbarum polysaccharides extend the mean lifespan of Drosophila melanogaster. / 17.07.2019 / PubMed / Full text
Height loss but not body composition is related to low back pain in community-dwelling elderlies: Shimane CoHRE study. / 10.05.2019 / PubMed / Full text
Aging of mouse intervertebral disc and association with back pain. / 06.2019 / PubMed / Full text
A comparison of the mitochondrial proteome and lipidome in the mouse and long-lived Pipistrelle bats. / 19.03.2019 / PubMed / Full text
Chen-Style Tai Chi for Individuals (Aged 50 Years Old or Above) with Chronic Non-Specific Low Back Pain: A Randomized Controlled Trial. / 12.02.2019 / PubMed / Full text
Lysosomal Signaling Promotes Longevity by Adjusting Mitochondrial Activity. / 11.03.2019 / PubMed / Full text
Factors associated with lumbar disc high-intensity zone (HIZ) on T2-weighted magnetic resonance image: a retrospective study of 3185 discs in 637 patients. / 04.12.2018 / PubMed / Full text
Urolithin A Inhibits the Catabolic Effect of TNFα on Nucleus Pulposus Cell and Alleviates Intervertebral Disc Degeneration [i]in vivo[/i]. / 2018 / PubMed / Full text
Use of trunk muscle training and neuromuscular electrical stimulation to reduce pain and disability in an older adult with chronic low back pain: A case report. / 08.2019 / PubMed / Full text
Endotoxemia is modulated by quantity and quality of dietary fat in older adults. / 08.2018 / PubMed / Full text
Correlates of a Recent History of Disabling Low Back Pain in Community-dwelling Older Persons: The Pain in the Elderly (PAINEL) Study. / 06.2018 / PubMed / Full text
The Effectiveness and Safety of Manual Therapy on Pain and Disability in Older Persons With Chronic Low Back Pain: A Systematic Review. / 09.2017 / PubMed / Full text
De-educate to re-educate: aging and low back pain. / 12.2017 / PubMed / Full text
Activity of Erector Spinae During Trunk Forward Bending and Backward Return: The Effects of Age. / 06.2017 / PubMed / Full text
Global Cysteine-Reactivity Profiling during Impaired Insulin/IGF-1 Signaling in C. elegans Identifies Uncharacterized Mediators of Longevity. / 18.08.2016 / PubMed / Full text
Age- and brain region-dependent α-synuclein oligomerization is attributed to alterations in intrinsic enzymes regulating α-synuclein phosphorylation in aging monkey brains. / 23.02.2016 / PubMed / Full text
Association of Lipopolysaccharide-Binding Protein With Aging-Related Adiposity Change and Prediabetes Among African Ancestry Men. / 03.2016 / PubMed / Full text
Age-related differences in trunk intrinsic stiffness. / 11.04.2016 / PubMed / Full text
Probiotics Reduce Inflammation in Antiretroviral Treated, HIV-Infected Individuals: Results of the "Probio-HIV" Clinical Trial. / 2015 / PubMed / Full text
The effects of age and gender on the lumbopelvic rhythm in the sagittal plane in 309 subjects. / 18.09.2015 / PubMed / Full text
Does physical activity moderate the relationship between depression symptomatology and low back pain? Cohort and co-twin control analyses nested in the longitudinal study of aging Danish twins (LSADT). / 04.2016 / PubMed / Full text
Aging. Lysosomal signaling molecules regulate longevity in Caenorhabditis elegans. / 02.01.2015 / PubMed / Full text
Comparative study of human age estimation with or without preclassification of gender and facial expression. / 2014 / PubMed / Full text

LPA

Ginseng gintonin, aging societies, and geriatric brain diseases. / 03.2021 / PubMed / Full text
Late-life related subtypes of depression - a data-driven approach on cognitive domains and physical frailty. / 22.05.2020 / PubMed / Full text
Does sedentary time increase in older adults in the days following participation in intense exercise? / 12.2020 / PubMed / Full text
Association of Long-term Exposure to Elevated Lipoprotein(a) Levels With Parental Life Span, Chronic Disease-Free Survival, and Mortality Risk: A Mendelian Randomization Analysis. / 05.02.2020 / PubMed / Full text
Elevated Autotaxin and LPA Levels During Chronic Viral Hepatitis and Hepatocellular Carcinoma Associate with Systemic Immune Activation. / 25.11.2019 / PubMed / Full text
Lysophosphatidic acid receptor LPA prevents oxidative stress and cellular senescence in Hutchinson-Gilford progeria syndrome. / 01.2020 / PubMed / Full text
Associations of Sedentary and Physically-Active Behaviors With Cognitive-Function Decline in Community-Dwelling Older Adults: Compositional Data Analysis From the NEIGE Study. / 05.11.2020 / PubMed / Full text
Validation and comparison of two automated methods for quantifying brain white matter hyperintensities of presumed vascular origin. / 02.2020 / PubMed / Full text
The Sedentary Time and Physical Activity Levels on Physical Fitness in the Elderly: A Comparative Cross Sectional Study. / 01.10.2019 / PubMed / Full text
Light-Intensity Physical Activity in a Large Prospective Cohort of Older US Adults: A 21-Year Follow-Up of Mortality. / 2020 / PubMed / Full text
The Impact of Movement Behaviors on Bone Health in Elderly with Adequate Nutritional Status: Compositional Data Analysis Depending on the Frailty Status. / 09.03.2019 / PubMed / Full text
Compositional Influence of Movement Behaviors on Bone Health during Aging. / 08.2019 / PubMed / Full text
Duration-Response of Light-Intensity Physical Activity and Glucose Dynamics in Older Adults. / 01.01.2019 / PubMed / Full text
Accelerometer-Measured Physical Activity and Sedentary Behavior: A Cross-Sectional Study of Brazilian Older Adults. / 01.11.2018 / PubMed / Full text
The Association Between Physical Activity, Including Physical Activity Intensity, and Fear of Falling Differs by Fear Severity in Older Adults Living in the Community. / 16.04.2020 / PubMed / Full text
Gintonin Attenuates D-Galactose-Induced Hippocampal Senescence by Improving Long-Term Hippocampal Potentiation, Neurogenesis, and Cognitive Functions. / 2018 / PubMed / Full text
Associations of distinct levels of physical activity with mobility in independent healthy older women. / 09.2018 / PubMed / Full text
Reallocating Accelerometer-Assessed Sedentary Time to Light or Moderate- to Vigorous-Intensity Physical Activity Reduces Frailty Levels in Older Adults: An Isotemporal Substitution Approach in the TSHA Study. / 02.2018 / PubMed / Full text
Lean psoas area does not correlate with clinical outcomes in moderately to severely injured older people. / 03.2018 / PubMed / Full text
Genome-wide meta-analysis associates HLA-DQA1/DRB1 and LPA and lifestyle factors with human longevity. / 13.10.2017 / PubMed / Full text
Stress, Depression, Resilience and Ageing: A Role for the LPA-LPA1 Pathway. / 05.03.2018 / PubMed / Full text
A New Anti-Aging Lysophosphatidic Acid from Arabidopsis thaliana. / 2017 / PubMed / Full text
Short-duration increases in intraluminal pressure improve vasoconstrictor responses in aged skeletal muscle feed arteries. / 05.2016 / PubMed / Full text
Hearing loss and cognition in the Busselton Baby Boomer cohort: An epidemiological study. / 10.2016 / PubMed / Full text
The Bulk of Autotaxin Activity Is Dispensable for Adult Mouse Life. / 2015 / PubMed / Full text
Cognitive function in midlife and beyond: physical and cognitive activity related to episodic memory and executive functions. / 2014 / PubMed / Full text
Effect of light and vigorous physical activity on balance and gait of older adults. / 11-12.2014 / PubMed / Full text
Inverse effects of midlife occupational and leisure time physical activity on mobility limitation in old age--a 28-year prospective follow-up study. / 05.2014 / PubMed / Full text

NPY

Neuropeptide Y Enhances Progerin Clearance and Ameliorates the Senescent Phenotype of Human Hutchinson-Gilford Progeria Syndrome Cells. / 22.05.2020 / PubMed / Full text
Effects of rikkunshito supplementation on resistance to oxidative stress and lifespan in mice. / 03.2020 / PubMed / Full text
Autophagy within the mushroom body protects from synapse aging in a non-cell autonomous manner. / 21.03.2019 / PubMed / Full text
β-Alanine supplementation reduces anxiety and increases neurotrophin expression in both young and older rats. / 02.2019 / PubMed / Full text
Age-related central regulation of orexin and NPY in the short-lived African killifish Nothobranchius furzeri. / 15.05.2019 / PubMed / Full text
Chronic treatment with tributyltin induces sexually dimorphic alterations in the hypothalamic POMC system of adult mice. / 12.2018 / PubMed / Full text
Expression of CGRP neurotransmitter and vascular genesis marker mRNA is age-dependent in superior cervical ganglia of senescence-accelerated prone mice. / 18.01.2018 / PubMed / Full text
Comparing the Effects of Melatonin with Caloric Restriction in the Hippocampus of Aging Mice: Involvement of Sirtuin1 and the FOXOs Pathway. / 01.2018 / PubMed / Full text
Bioactive growth hormone in older men and women: It's relationship to immune markers and healthspan. / 06.2017 / PubMed / Full text
Retinal, NPY- and 5ht- inputs to the aged suprachiasmatic nucleus in common marmosets (Callithrix jacchus). / 08.2017 / PubMed / Full text
Long-lasting memory deficits in mice withdrawn from cocaine are concomitant with neuroadaptations in hippocampal basal activity, GABAergic interneurons and adult neurogenesis. / 01.03.2017 / PubMed / Full text
Neuropeptide Y resists excess loss of fat by lipolysis in calorie-restricted mice: a trait potential for the life-extending effect of calorie restriction. / 04.2017 / PubMed / Full text
Nerve growth factor-induced plasticity in medial prefrontal cortex interneurons of aged Wistar rats. / 01.12.2016 / PubMed / Full text
Age Impaired endothelium-dependent vasodilation is improved by resveratrol in rat mesenteric arteries. / 31.03.2016 / PubMed / Full text
Age-related changes in neurochemical components and retinal projections of rat intergeniculate leaflet. / 02.2016 / PubMed / Full text
Short photoperiod condition increases susceptibility to stress in adolescent male rats. / 01.03.2016 / PubMed / Full text
Neuropeptide Y: An Anti-Aging Player? / 11.2015 / PubMed / Full text
Influence of Aging and Gender Differences on Feeding Behavior and Ghrelin-Related Factors during Social Isolation in Mice. / 2015 / PubMed / Full text
Reduction in NPY-positive neurons and dysregulation of excitability in young senescence-accelerated mouse prone 8 (SAMP8) hippocampus precede the onset of cognitive impairment. / 10.2015 / PubMed / Full text
Age effects on the nucleus of the lateral olfactory tract of the rat. / 01.03.2016 / PubMed / Full text
NPY/neuropeptide Y enhances autophagy in the hypothalamus: a mechanism to delay aging? / 2015 / PubMed / Full text
Analysis of gene expression during aging of CGNs in culture: implication of SLIT2 and NPY in senescence. / 06.2015 / PubMed / Full text
Neuropeptide Y stimulates autophagy in hypothalamic neurons. / 31.03.2015 / PubMed / Full text
Effect of IP3R3 and NPY on age-related declines in olfactory stem cell proliferation. / 02.2015 / PubMed / Full text
Old-onset caloric restriction effects on neuropeptide Y- and somatostatin-containing neurons and on cholinergic varicosities in the rat hippocampal formation. / 2014 / PubMed / Full text
Orally administered δ opioid agonist peptide rubiscolin-6 stimulates food intake in aged mice with ghrelin resistance. / 10.2014 / PubMed / Full text
Ghrelin receptor regulates appetite and satiety during aging in mice by regulating meal frequency and portion size but not total food intake. / 09.2014 / PubMed / Full text
Distribution of peptidergic populations in the human dentate gyrus (somatostatin [SOM-28, SOM-12] and neuropeptide Y [[[NPY]]]) during postnatal development. / 10.2014 / PubMed / Full text

ATF4

Endoplasmic Reticulum Stress Mediates Vascular Smooth Muscle Cell Calcification via Increased Release of Grp78-Loaded Extracellular Vesicles. / 10.12.2020 / PubMed / Full text
Extracellular acidosis triggers a senescence-like phenotype in human melanoma cells. / 01.2020 / PubMed / Full text
Chronic and age-dependent effects of the spongiform neurodegeneration-associated MGRN1 E3 ubiquitin ligase on mitochondrial homeostasis. / 06.2019 / PubMed / Full text
Expression of lipogenic markers is decreased in subcutaneous adipose tissue and adipocytes of older women and is negatively linked to GDF15 expression. / 08.2019 / PubMed / Full text
Effects of a resistance-training programme on endoplasmic reticulum unfolded protein response and mitochondrial functions in PBMCs from elderly subjects. / 08.2019 / PubMed / Full text
[Protective effect of Wuzi Yanzong recipe on testicular germ cell apoptosis in natural ageing rats through endoplasmic reticulum stress]. / 10.2018 / PubMed / Full text
Protective effect of Wuzi Yanzong recipe on testicular dysfunction through inhibition of germ cell apoptosis in ageing rats via endoplasmic reticulum stress. / 03.2019 / PubMed / Full text
Loss of NRF-2 and PGC-1α genes leads to retinal pigment epithelium damage resembling dry age-related macular degeneration. / 01.2019 / PubMed / Full text
Inhibition of glioma growth by flavokawain B is mediated through endoplasmic reticulum stress induced autophagy. / 2018 / PubMed / Full text
De-silencing [i]Grb10[/i] contributes to acute ER stress-induced steatosis in mouse liver. / 05.2018 / PubMed / Full text
Resveratrol modulates response against acute inflammatory stimuli in aged mouse brain. / 02.2018 / PubMed / Full text
Integrated stress response stimulates FGF21 expression: Systemic enhancer of longevity. / 12.2017 / PubMed / Full text
Role of ATF4 in skeletal muscle atrophy. / 05.2017 / PubMed / Full text
4E-BP is a target of the GCN2-ATF4 pathway during Drosophila development and aging. / 02.01.2017 / PubMed / Full text
Diaminodiphenyl sulfone-induced parkin ameliorates age-dependent dopaminergic neuronal loss. / 05.2016 / PubMed / Full text
Different Roles of Negative and Positive Components of the Circadian Clock in Oncogene-induced Neoplastic Transformation. / 13.05.2016 / PubMed / Full text
Differentiated embryo chondrocyte 1 (DEC1) is a novel negative regulator of hepatic fibroblast growth factor 21 (FGF21) in aging mice. / 15.01.2016 / PubMed / Full text
Unfolded protein response is activated in aged retinas. / 16.11.2015 / PubMed / Full text
Identification and Small Molecule Inhibition of an Activating Transcription Factor 4 (ATF4)-dependent Pathway to Age-related Skeletal Muscle Weakness and Atrophy. / 16.10.2015 / PubMed / Full text
Effect of mitochondrial stress on systemic metabolism. / 09.2015 / PubMed / Full text
Senescence may mediate conversion of tau phosphorylation-induced apoptotic escape to neurodegeneration. / 08.2015 / PubMed / Full text
Impact of ER stress-regulated ATF4/p16 signaling on the premature senescence of renal tubular epithelial cells in diabetic nephropathy. / 15.04.2015 / PubMed / Full text
ATF4 activity: a common feature shared by many kinds of slow-aging mice. / 12.2014 / PubMed / Full text
The unfolded protein response is triggered following a single, unaccustomed resistance-exercise bout. / 15.09.2014 / PubMed / Full text
Methionine restriction restores a younger metabolic phenotype in adult mice with alterations in fibroblast growth factor 21. / 10.2014 / PubMed / Full text
The first international mini-symposium on methionine restriction and lifespan. / 2014 / PubMed / Full text
Elevated ATF4 function in fibroblasts and liver of slow-aging mutant mice. / 03.2015 / PubMed / Full text

DDT

Prognostic Value of a Test of Central Auditory Function in Conversion from Mild Cognitive Impairment to Dementia. / 2020 / PubMed / Full text
Uptake kinetics of four hydrophobic organic pollutants in the earthworm Eisenia andrei in aged laboratory-contaminated natural soils. / 01.04.2020 / PubMed / Full text
Adult exposure to insecticides causes persistent behavioral and neurochemical alterations in zebrafish. / 03-04.2020 / PubMed / Full text
Second generation effects of larval metal pollutant exposure on reproduction, longevity and insecticide tolerance in the major malaria vector Anopheles arabiensis (Diptera: Culicidae). / 07.01.2020 / PubMed / Full text
Protective effect of Pedro-Ximénez must against p,p'-DDE-induced liver damages in aged Mus spretus mice. / 02.2020 / PubMed / Full text
Low-dose endosulfan inhibits proliferation and induces senescence and pro-inflammatory cytokine production in human lymphocytes, preferentially impacting cytotoxic cells. / 12.2019 / PubMed / Full text
DNA damage tolerance in stem cells, ageing, mutagenesis, disease and cancer therapy. / 22.08.2019 / PubMed / Full text
The contribution of gut bacteria to insecticide resistance and the life histories of the major malaria vector Anopheles arabiensis (Diptera: Culicidae). / 24.06.2019 / PubMed / Full text
Exposure to the insecticide-treated bednet PermaNet 2.0 reduces the longevity of the wild African malaria vector Anopheles funestus but GSTe2-resistant mosquitoes live longer. / 2019 / PubMed / Full text
The occurrence and dynamics of polychlorinated hydrocarbons in roe deer ([i]Capreolus capreolus[/i]) in South-western Slovakia. / 2019 / PubMed / Full text
Insecticide resistance status of three vectors of Japanese encephalitis in east central India. / 06.2019 / PubMed / Full text
Effect of aging on bioaccessibility of DDTs and PCBs in marine sediment. / 02.2019 / PubMed / Full text
The effect of commercial herbicide exposure on the life history and insecticide resistance phenotypes of the major malaria vector Anopheles arabiensis (Diptera: culicidae). / 12.2018 / PubMed / Full text
Is Chronic Exposure to Low-Dose Organochlorine Pesticides a New Risk Factor of T-cell Immunosenescence? / 10.2018 / PubMed / Full text
The influence of age on insecticide susceptibility of Anopheles arabiensis during dry and rainy seasons in rice irrigation schemes of Northern Tanzania. / 11.09.2017 / PubMed / Full text
DNA damage tolerance in hematopoietic stem and progenitor cells in mice. / 15.08.2017 / PubMed / Full text
The effects of ingestion of hormonal host factors on the longevity and insecticide resistance phenotype of the major malaria vector Anopheles arabiensis (Diptera: Culicidae). / 2017 / PubMed / Full text
Bioavailability of five hydrophobic organic compounds to earthworms from sterile and non-sterile artificial soils. / 07.2017 / PubMed / Full text
The effect of elevated temperatures on the life history and insecticide resistance phenotype of the major malaria vector Anopheles arabiensis (Diptera: Culicidae). / 14.02.2017 / PubMed / Full text
Dichotic Digits Test Performance Across the Ages: Results From Two Large Epidemiologic Cohort Studies. / 05-06.2017 / PubMed / Full text
The Role of Oxidative Stress in the Longevity and Insecticide Resistance Phenotype of the Major Malaria Vectors Anopheles arabiensis and Anopheles funestus. / 2016 / PubMed / Full text
Nuclear hormone receptor DHR96 mediates the resistance to xenobiotics but not the increased lifespan of insulin-mutant Drosophila. / 02.02.2016 / PubMed / Full text
Influence of feeding and earthworm density on compound bioaccumulation in earthworms Eisenia andrei. / 12.2015 / PubMed / Full text
Greater cognitive decline with aging among elders with high serum concentrations of organochlorine pesticides. / 2015 / PubMed / Full text
The effect of multiple blood-feeding on the longevity and insecticide resistant phenotype in the major malaria vector Anopheles arabiensis (Diptera: Culicidae). / 23.08.2014 / PubMed / Full text
The role of canine distemper virus and persistent organic pollutants in mortality patterns of Caspian seals (Pusa caspica). / 2014 / PubMed / Full text
Solid phase microextraction of organic pollutants from natural and artificial soils and comparison with bioaccumulation in earthworms. / 02.2014 / PubMed / Full text

FOXO1

l-Theanine attenuates liver aging by inhibiting advanced glycation end products in d-galactose-induced rats and reversing an imbalance of oxidative stress and inflammation. / 03.2020 / PubMed / Full text
Establishment of a Mouse Model of Premature Ovarian Failure Using Consecutive Superovulation. / 2018 / PubMed / Full text
Functional pathways regulated by microRNA networks in CD8 T-cell aging. / 02.2019 / PubMed / Full text
Introduction to FOXO Biology. / 2019 / PubMed / Full text
Antioxidant modifications induced by the new metformin derivative HL156A regulate metabolic reprogramming in SAMP1/kl (-/-) mice. / 16.09.2018 / PubMed / Full text
Master athletes have higher miR-7, SIRT3 and SOD2 expression in skeletal muscle than age-matched sedentary controls. / 10.2018 / PubMed / Full text
FOXO1 and ETV6 genes may represent novel regulators of splicing factor expression in cellular senescence. / 01.2019 / PubMed / Full text
Autophagy mediators (FOXO1, SESN3 and TSC2) in Lewy body disease and aging. / 25.09.2018 / PubMed / Full text
FOXO are required for intervertebral disk homeostasis during aging and their deficiency promotes disk degeneration. / 10.2018 / PubMed / Full text
Senescence Alters PPARγ (Peroxisome Proliferator-Activated Receptor Gamma)-Dependent Fatty Acid Handling in Human Adipose Tissue Microvascular Endothelial Cells and Favors Inflammation. / 05.2018 / PubMed / Full text
HGF and BFGF Secretion by Human Adipose-Derived Stem Cells Improves Ovarian Function During Natural Aging via Activation of the SIRT1/FOXO1 Signaling Pathway. / 2018 / PubMed / Full text
Role of Forkhead Box O (FOXO) transcription factor in aging and diseases. / 30.03.2018 / PubMed / Full text
FOXO in Neural Cells and Diseases of the Nervous System. / 2018 / PubMed / Full text
Clearance of senescent decidual cells by uterine natural killer cells in cycling human endometrium. / 11.12.2017 / PubMed / Full text
FOXO Transcriptional Factors and Long-Term Living. / 2017 / PubMed / Full text
Aquatide Activation of SIRT1 Reduces Cellular Senescence through a SIRT1-FOXO1-Autophagy Axis. / 01.09.2017 / PubMed / Full text
The protein kinase MBK-1 contributes to lifespan extension in [i]daf-2[/i] mutant and germline-deficient [i]Caenorhabditis elegans[/i]. / 25.05.2017 / PubMed / Full text
Melatonin regulates the aging mouse hippocampal homeostasis via the sirtuin1-FOXO1 pathway. / 2017 / PubMed / Full text
Caloric restriction delays early phases of carcinogenesis via effects on the tissue microenvironment. / 30.05.2017 / PubMed / Full text
Age-related reduction in the expression of FOXO transcription factors and correlations with intervertebral disc degeneration. / 12.2017 / PubMed / Full text
Oxidative Stress-Induced miR-200c Disrupts the Regulatory Loop Among SIRT1, FOXO1, and eNOS. / 20.08.2017 / PubMed / Full text
miR-96, miR-145 and miR-9 expression increases, and IGF-1R and FOXO1 expression decreases in peripheral blood mononuclear cells of aging humans. / 30.11.2016 / PubMed / Full text
Cone Viability Is Affected by Disruption of Melatonin Receptors Signaling. / 01.01.2016 / PubMed / Full text
Effect of Aging on Periodontal Inflammation, Microbial Colonization, and Disease Susceptibility. / 04.2016 / PubMed / Full text
Long live FOXO: unraveling the role of FOXO proteins in aging and longevity. / 04.2016 / PubMed / Full text
Abrogation of Age-Induced MicroRNA-195 Rejuvenates the Senescent Mesenchymal Stem Cells by Reactivating Telomerase. / 01.2016 / PubMed / Full text
Endogenous ROS levels are increased in replicative senescence in human bone marrow mesenchymal stromal cells. / 15.05.2015 / PubMed / Full text

HMGB1

Senescent human melanocytes drive skin ageing via paracrine telomere dysfunction. / 02.12.2019 / PubMed / Full text
Targeting HMGB1 by ethyl pyruvate ameliorates systemic lupus erythematosus and reverses the senescent phenotype of bone marrow-mesenchymal stem cells. / 14.07.2019 / PubMed / Full text
HMGB1 and Caveolin-1 related to RPE cell senescence in age-related macular degeneration. / 07.07.2019 / PubMed / Full text
Dual faced HMGB1 plays multiple roles in cardiomyocyte senescence and cardiac inflammatory injury. / 06.2019 / PubMed / Full text
Neuroprotective Effect of Dioscin on the Aging Brain. / 30.03.2019 / PubMed / Full text
Modulation of soluble receptor for advanced glycation end-products (RAGE) isoforms and their ligands in healthy aging. / 23.03.2019 / PubMed / Full text
Cellular senescence in progenitor cells contributes to diminished remyelination potential in progressive multiple sclerosis. / 30.04.2019 / PubMed / Full text
Serum and nutrient deprivation increase autophagic flux in intervertebral disc annulus fibrosus cells: an in vitro experimental study. / 05.2019 / PubMed / Full text
Sirt3 mediates the protective effect of hydrogen in inhibiting ROS-induced retinal senescence. / 01.05.2019 / PubMed / Full text
Towards frailty biomarkers: Candidates from genes and pathways regulated in aging and age-related diseases. / 11.2018 / PubMed / Full text
Repeated abortion in adulthood induces cognition impairment in aged mice. / 30.07.2018 / PubMed / Full text
Loss of DNA polymerase β induces cellular senescence. / 08.2018 / PubMed / Full text
Nicotine-Induced Neuroprotection against Cognitive Dysfunction after Partial Hepatectomy Involves Activation of BDNF/TrkB Signaling Pathway and Inhibition of NF-κB Signaling Pathway in Aged Rats. / 06.03.2018 / PubMed / Full text
Intestinal Permeability Biomarker Zonulin is Elevated in Healthy Aging. / 01.09.2017 / PubMed / Full text
Disruption of the Cx43/miR21 pathway leads to osteocyte apoptosis and increased osteoclastogenesis with aging. / 06.2017 / PubMed / Full text
Changes in pro-inflammatory markers and leucine concentrations in response to Nordic Walking training combined with vitamin D supplementation in elderly women. / 08.2017 / PubMed / Full text
Systemic HMGB1 Neutralization Prevents Postoperative Neurocognitive Dysfunction in Aged Rats. / 2016 / PubMed / Full text
The Alarmin HMGB1 Mediates Age-Induced Neuroinflammatory Priming. / 27.07.2016 / PubMed / Full text
Human fetal membranes at term: Dead tissue or signalers of parturition? / 08.2016 / PubMed / Full text
Modulation of Macrophage Polarization and HMGB1-TLR2/TLR4 Cascade Plays a Crucial Role for Cardiac Remodeling in Senescence-Accelerated Prone Mice. / 2016 / PubMed / Full text
DAMPs and influenza virus infection in ageing. / 11.2015 / PubMed / Full text
Decreased serum level of HMGB1 and MyD88 during human aging progress in healthy individuals. / 04.2016 / PubMed / Full text
[Peptides and [[CCL11]] and HMGB1 as molecular markers of aging: literature review and own data]. / 2014 / PubMed
HMGB1 facilitates repair of mitochondrial DNA damage and extends the lifespan of mutant ataxin-1 knock-in mice. / 01.2015 / PubMed / Full text
Secondhand smoke exposure-induced nucleocytoplasmic shuttling of HMGB1 in a rat premature skin aging model. / 02.01.2015 / PubMed / Full text
Changes in the expression of the Toll-like receptor system in the aging rat kidneys. / 2014 / PubMed / Full text
Brain innate immunity in the regulation of neuroinflammation: therapeutic strategies by modulating CD200-CD200R interaction involve the cannabinoid system. / 2014 / PubMed / Full text

KL

The goddess who spins the thread of life: Klotho, psychiatric stress, and accelerated aging. / 08.2019 / PubMed / Full text
[i]KLOTHO[/i] heterozygosity attenuates [i]APOE4[/i]-related amyloid burden in preclinical AD. / 16.04.2019 / PubMed / Full text
Utilizing Atlas-Based Modeling to Predict Knee Joint Cartilage Degeneration: Data from the Osteoarthritis Initiative. / 03.2019 / PubMed / Full text
Impaired proteostasis in senescent vascular endothelial cells: a perspective on estrogen and oxidative stress in the aging vasculature. / 01.02.2019 / PubMed / Full text
Leukocyte Telomere Length in Patients with Radiographic Knee Osteoarthritis. / 04.2019 / PubMed / Full text
Klotho at the Edge of Alzheimer's Disease and Senile Depression. / 03.2019 / PubMed / Full text
Review and meta-analysis of genetic polymorphisms associated with exceptional human longevity. / 10.2018 / PubMed / Full text
G-395A polymorphism in the promoter region of the KLOTHO gene associates with frailty among the oldest-old. / 30.04.2018 / PubMed / Full text
Protective Effect of Klotho against Ischemic Brain Injury Is Associated with Inhibition of RIG-I/NF-κB Signaling. / 2017 / PubMed / Full text
Changes in expression of klotho affect physiological processes, diseases, and cancer. / 01.2018 / PubMed / Full text
Anti-aging factor, serum alpha-Klotho, as a marker of acute physiological stress, and a predictor of ICU mortality, in patients with septic shock. / 04.2018 / PubMed / Full text
Secreted αKlotho isoform protects against age-dependent memory deficits. / 09.2018 / PubMed / Full text
Induction of anti-aging gene klotho with a small chemical compound that demethylates CpG islands. / 18.07.2017 / PubMed / Full text
Longevity Klotho gene polymorphism and the risk of dementia in older men. / 07.2017 / PubMed / Full text
Klotho, APOEε4, cognitive ability, brain size, atrophy, and survival: a study in the Aberdeen Birth Cohort of 1936. / 07.2017 / PubMed / Full text
The relevance of α-KLOTHO to the central nervous system: Some key questions. / 07.2017 / PubMed / Full text
Systemic klotho is associated with KLOTHO variation and predicts intrinsic cortical connectivity in healthy human aging. / 04.2017 / PubMed / Full text
Activation of SIRT1 Attenuates Klotho Deficiency-Induced Arterial Stiffness and Hypertension by Enhancing AMP-Activated Protein Kinase Activity. / 11.2016 / PubMed / Full text
The FGF23/KLOTHO Regulatory Network and Its Roles in Human Disorders. / 2016 / PubMed / Full text
Antiaging Gene Klotho Deficiency Promoted High-Fat Diet-Induced Arterial Stiffening via Inactivation of AMP-Activated Protein Kinase. / 03.2016 / PubMed / Full text
KL-optimal experimental design for discriminating between two growth models applied to a beef farm. / 02.2016 / PubMed / Full text
Secreted and Transmembrane αKlotho Isoforms Have Different Spatio-Temporal Profiles in the Brain during Aging and Alzheimer's Disease Progression. / 2015 / PubMed / Full text
Genetic Variants in KLOTHO Associate With Cognitive Function in the Oldest Old Group. / 09.2016 / PubMed / Full text
N-ethyl-N-Nitrosourea (ENU) induced mutations within the klotho gene lead to ectopic calcification and reduced lifespan in mouse models. / 2015 / PubMed / Full text
Senescence-inducible LEC2 enhances triacylglycerol accumulation in leaves without negatively affecting plant growth. / 12.2015 / PubMed / Full text
Molecular basis of Klotho: from gene to function in aging. / 04.2015 / PubMed / Full text
Life extension factor klotho enhances cognition. / 22.05.2014 / PubMed / Full text

TFAM

Late life maintenance and enhancement of functional exercise capacity in low and high responding rats after low intensity treadmill training. / 01.10.2019 / PubMed / Full text
Maternal ageing impairs mitochondrial DNA kinetics during early embryogenesis in mice. / 08.07.2019 / PubMed / Full text
Differences in Liver TFAM Binding to mtDNA and mtDNA Damage between Aged and Extremely Aged Rats. / 27.05.2019 / PubMed / Full text
Photobiomodulation and Coenzyme Q Treatments Attenuate Cognitive Impairment Associated With Model of Transient Global Brain Ischemia in Artificially Aged Mice. / 2019 / PubMed / Full text
[A study on alterations in mitochondrial biological characteristics during cellular senescence of human embryonic lung fibroblasts]. / 06.03.2019 / PubMed / Full text
Changes in Stemness Properties, Differentiation Potential, Oxidative Stress, Senescence and Mitochondrial Function in Wharton's Jelly Stem Cells of Umbilical Cords of Mothers with Gestational Diabetes Mellitus. / 06.2019 / PubMed / Full text
Cycling CD4 T cells in HIV-infected immune nonresponders have mitochondrial dysfunction. / 01.11.2018 / PubMed / Full text
Increased TFAM binding to mtDNA damage hot spots is associated with mtDNA loss in aged rat heart. / 20.08.2018 / PubMed / Full text
Restoring mitochondrial DNA copy number preserves mitochondrial function and delays vascular aging in mice. / 08.2018 / PubMed / Full text
Sestrin2 prevents age-related intolerance to post myocardial infarction via AMPK/PGC-1α pathway. / 02.2018 / PubMed / Full text
Skeletal muscle from aged American Quarter Horses shows impairments in mitochondrial biogenesis and expression of autophagy markers. / 02.2018 / PubMed / Full text
Dietary supplementation with acetyl-l-carnitine counteracts age-related alterations of mitochondrial biogenesis, dynamics and antioxidant defenses in brain of old rats. / 11.2017 / PubMed / Full text
Effect of lifelong football training on the expression of muscle molecular markers involved in healthy longevity. / 04.2017 / PubMed / Full text
Regulation of mitochondrial gene expression, the epigenetic enigma. / 01.03.2017 / PubMed / Full text
Poor embryo development in post-ovulatory in vivo-aged mouse oocytes is associated with mitochondrial dysfunction, but mitochondrial transfer from somatic cells is not sufficient for rejuvenation. / 10.2016 / PubMed / Full text
Disentangling the effect of dietary restriction on mitochondrial function using recombinant inbred mice. / 05.11.2017 / PubMed / Full text
"What makes some rats live so long?" The mitochondrial contribution to longevity through balance of mitochondrial dynamics and mtDNA content. / 01.12.2016 / PubMed / Full text
Response of BAX, Bcl-2 Proteins, and SIRT1/PGC-1α mRNA Expression to 8-Week Treadmill Running in the Aging Rat Skeletal Muscle. / 2016 / PubMed / Full text
Methylene blue improves sensorimotor phenotype and decreases anxiety in parallel with activating brain mitochondria biogenesis in mid-age mice. / 12.2016 / PubMed / Full text
HIF-1 regulates insect lifespan extension by inhibiting c-Myc-TFAM signaling and mitochondrial biogenesis. / 11.2016 / PubMed / Full text
Resistance exercise training and in vitro skeletal muscle oxidative capacity in older adults. / 07.2016 / PubMed / Full text
Mitochondrial Lon protease in human disease and aging: Including an etiologic classification of Lon-related diseases and disorders. / 11.2016 / PubMed / Full text
Resveratrol attenuates senescence of adipose-derived mesenchymal stem cells and restores their paracrine effects on promoting insulin secretion of INS-1 cells through Pim-1. / 2016 / PubMed
Regulation of mitochondrial biogenesis through TFAM-mitochondrial DNA interactions: Useful insights from aging and calorie restriction studies. / 11.2015 / PubMed / Full text
Dietary Tocotrienol/γ-Cyclodextrin Complex Increases Mitochondrial Membrane Potential and ATP Concentrations in the Brains of Aged Mice. / 2015 / PubMed / Full text
A comparison among the tissue-specific effects of aging and calorie restriction on TFAM amount and TFAM-binding activity to mtDNA in rat. / 07.2014 / PubMed / Full text
Partial reversal of skeletal muscle aging by restoration of normal NAD⁺ levels. / 02.2014 / PubMed / Full text

ASL

Increased blood-brain barrier permeability to water in the aging brain detected using noninvasive multi-TE ASL MRI. / 01.2021 / PubMed / Full text
Quantitative Cerebrovascular Reactivity in Normal Aging: Comparison Between Phase-Contrast and Arterial Spin Labeling MRI. / 2020 / PubMed / Full text
Correcting Task fMRI Signals for Variability in Baseline CBF Improves BOLD-Behavior Relationships: A Feasibility Study in an Aging Model. / 2020 / PubMed / Full text
Cerebral Blood Flow in Community-Based Older Twins Is Moderately Heritable: An Arterial Spin Labeling Perfusion Imaging Study. / 2019 / PubMed / Full text
A longitudinal characterization of perfusion in the aging brain and associations with cognition and neural structure. / 15.08.2019 / PubMed / Full text
Cortical cerebral blood flow in ageing: effects of haematocrit, sex, ethnicity and diabetes. / 10.2019 / PubMed / Full text
Exercise-stimulated arterial transit time in calf muscles measured by dynamic contrast-enhanced magnetic resonance imaging. / 01.2019 / PubMed / Full text
Impact of Coffee, Wine, and Chocolate Consumption on Cognitive Outcome and MRI Parameters in Old Age. / 01.10.2018 / PubMed / Full text
Potential Role of OERP as Early Marker of Mild Cognitive Impairment. / 2018 / PubMed / Full text
Reduced Regional Cerebral Blood Flow Relates to Poorer Cognition in Older Adults With Type 2 Diabetes. / 2018 / PubMed / Full text
The Age-Related Perfusion Pattern Measured With Arterial Spin Labeling MRI in Healthy Subjects. / 2018 / PubMed / Full text
Resilience and amygdala function in older healthy and depressed adults. / 09.2018 / PubMed / Full text
Does Aerobic Exercise Influence Intrinsic Brain Activity? An Aerobic Exercise Intervention among Healthy Old Adults. / 2017 / PubMed / Full text
Cerebral blood flow and vasoreactivity in aging: an arterial spin labeling study. / 23.03.2017 / PubMed / Full text
Cerebral blood flow measured by arterial spin labeling MRI at resting state in normal aging and Alzheimer's disease. / 01.2017 / PubMed / Full text
Cerebral blood flow MRI in the nondemented elderly is not predictive of post-operative delirium but is correlated with cognitive performance. / 04.2017 / PubMed / Full text
Improving drug retention in liposomes by aging with the aid of glucose. / 30.05.2016 / PubMed / Full text
The Utility of Cerebral Blood Flow as a Biomarker of Preclinical Alzheimer's Disease. / 03.2016 / PubMed / Full text
Long-term effect of orthokeratology on the anterior segment length. / 08.2016 / PubMed / Full text
Comparison of long-labeled pseudo-continuous arterial spin labeling (ASL) features between young and elderly adults: special reference to parameter selection. / 01.2017 / PubMed / Full text
Assessing intracranial vascular compliance using dynamic arterial spin labeling. / 01.01.2016 / PubMed / Full text
Lens Position and Age: The Central India Eye and Medical Study. / 08.2015 / PubMed / Full text
Age-related changes in brain hemodynamics; A calibrated MRI study. / 10.2015 / PubMed / Full text
Characterizing the white matter hyperintensity penumbra with cerebral blood flow measures. / 2015 / PubMed / Full text
Tissue specific arterial spin labeling fMRI: a superior method for imaging cerebral blood flow in aging and disease. / 2014 / PubMed / Full text
Metabolic and transcriptional response to a high-fat diet in Drosophila melanogaster. / 02.2014 / PubMed / Full text

BRCA1

Epigenome-wide exploratory study of monozygotic twins suggests differentially methylated regions to associate with hand grip strength. / 10.2019 / PubMed / Full text
PML nuclear bodies are recruited to persistent DNA damage lesions in an RNF168-53BP1 dependent manner and contribute to DNA repair. / 06.2019 / PubMed / Full text
Mechanistic link between DNA damage sensing, repairing and signaling factors and immune signaling. / 2019 / PubMed / Full text
Klotho gene polymorphisms are associated with healthy aging and longevity: Evidence from a meta-analysis. / 03.2019 / PubMed / Full text
High expression of the breast cancer susceptibility gene BRCA1 in long-lived termite kings. / 11.10.2018 / PubMed / Full text
The activated DNA double-strand break repair pathway in cumulus cells from aging patients may be used as a convincing predictor of poor outcomes after in vitro fertilization-embryo transfer treatment. / 2018 / PubMed / Full text
Cost effectiveness of population based BRCA1 founder mutation testing in Sephardi Jewish women. / 04.2018 / PubMed / Full text
Replication Stress Shapes a Protective Chromatin Environment across Fragile Genomic Regions. / 04.01.2018 / PubMed / Full text
Faulty BRCA1, BRCA2 genes: how poor is the prognosis? / 10.2017 / PubMed / Full text
Ovarian Aging in Women With BRCA Germline Mutations. / 01.10.2017 / PubMed / Full text
The expected benefit of preventive mastectomy on breast cancer incidence and mortality in BRCA mutation carriers, by age at mastectomy. / 01.2018 / PubMed / Full text
A BRCA1-Dependent DNA Damage Response in the Regenerating Adult Peripheral Nerve Milieu. / 05.2018 / PubMed / Full text
The Histone Variant MacroH2A1 Is a BRCA1 Ubiquitin Ligase Substrate. / 30.05.2017 / PubMed / Full text
A Multigene Test Could Cost-Effectively Help Extend Life Expectancy for Women at Risk of Hereditary Breast Cancer. / 04.2017 / PubMed / Full text
Serum AMH levels in healthy women from BRCA1/2 mutated families: are they reduced? / 11.2016 / PubMed / Full text
p16INK4a suppresses BRCA1-deficient mammary tumorigenesis. / 20.12.2016 / PubMed / Full text
BRCA-1 Gene Expression and Comparative Proteomic Profile of Primordial Follicles from Young and Adult Buffalo (Bubalus bubalis) Ovaries. / 03.04.2017 / PubMed / Full text
Women's preferences for contralateral prophylactic mastectomy: An investigation using protection motivation theory. / 05.2016 / PubMed / Full text
Accelerated geroncogenesis in hereditary breast-ovarian cancer syndrome. / 15.03.2016 / PubMed / Full text
Genetic suppression reveals DNA repair-independent antagonism between BRCA1 and COBRA1 in mammary gland development. / 04.03.2016 / PubMed / Full text
Large-scale genomic analyses link reproductive aging to hypothalamic signaling, breast cancer susceptibility and BRCA1-mediated DNA repair. / 11.2015 / PubMed / Full text
Comparative proteomic analysis of primordial follicles from ovaries of immature and aged rats. / 2015 / PubMed / Full text
BRCA Mutations, DNA Repair Deficiency, and Ovarian Aging. / 09.2015 / PubMed / Full text
Increased DNA damage and repair deficiency in granulosa cells are associated with ovarian aging in rhesus monkey. / 07.2015 / PubMed / Full text
Conservation of pro-longevity genes among mammals. / 03.2015 / PubMed / Full text
Targeting of DNA Damage Signaling Pathway Induced Senescence and Reduced Migration of Cancer cells. / 06.2015 / PubMed / Full text

C5

The C5-75 Program: Meeting the Need for Efficient, Pragmatic Frailty Screening and Management in Primary Care. / 23.06.2020 / PubMed / Full text
Can a relatively large spinal cord for the dural sac influence severity of paralysis in elderly patients with cervical spinal cord injury caused by minor trauma? / 26.06.2020 / PubMed / Full text
Age and Sex-Associated Changes of Complement Activity and Complement Levels in a Healthy Caucasian Population. / 2018 / PubMed / Full text
Longevity of adenovirus vector immunity in mice and its implications for vaccine efficacy. / 29.10.2018 / PubMed / Full text
Generating Rasch-based activity of daily living measures from the Spinal Cord Injury Longitudinal Aging Study. / 01.2018 / PubMed / Full text
A Large Cohort Study of 18F Fluoro-Deoxy-Glucose Uptake in Normal Spinal Cord: Quantitative Assessment of the Contamination From Adjacent Vertebral Marrow Uptake and Validity of Normalizing the Cord Uptake Against the Lumbar Thecal Sac. / 01.2017 / PubMed / Full text
Demographic aspects in cervical vertebral bodies' size and shape (C3-C7): a skeletal study. / 01.2017 / PubMed / Full text
Tract-specific and age-related variations of the spinal cord microstructure: a multi-parametric MRI study using diffusion tensor imaging (DTI) and inhomogeneous magnetization transfer (ihMT). / 06.2016 / PubMed / Full text
Age-related brain atrophy may be mitigated by internal jugular vein enlargement in male individuals without neurologic disease. / 03.2017 / PubMed / Full text
The incidence of cervical spondylosis decreases with aging in the elderly, and increases with aging in the young and adult population: a hospital-based clinical analysis. / 2016 / PubMed / Full text
Signal intensity loss of the intervertebral discs in the cervical spine of young patients on fluid sensitive sequences. / 03.2016 / PubMed / Full text
Are the standard parameters of cervical spine alignment and range of motion related to age, sex, and cervical disc degeneration? / 09.2015 / PubMed / Full text
DBA/2J genetic background exacerbates spontaneous lethal seizures but lessens amyloid deposition in a mouse model of Alzheimer's disease. / 2015 / PubMed / Full text
Permeability and shear modulus of articular cartilage in growing mice. / 02.2016 / PubMed / Full text
Acute exercise increases hippocampal TNF-α, Caspase-3 and Caspase-7 expression in healthy young and older mice. / 04.2015 / PubMed
Age influences inflammatory responses, hemodynamics, and cardiac proteasome activation during acute lung injury. / 05.2015 / PubMed / Full text
Minocycline enhances hippocampal memory, neuroplasticity and synapse-associated proteins in aged C57 BL/6 mice. / 05.2015 / PubMed / Full text
Presence of rd8 mutation does not alter the ocular phenotype of late-onset retinal degeneration mouse model. / 2015 / PubMed / Full text
Concentration- and age-dependent effects of chronic caffeine on contextual fear conditioning in C57BL/6J mice. / 01.02.2016 / PubMed / Full text
Miglitol protects against age-dependent weight gain in mice: A potential role of increased UCP1 content in brown adipose tissue. / 2015 / PubMed / Full text
Cathelicidin related antimicrobial peptide, laminin, Toll-like receptors and chemokines levels in experimental hypersensitivity pneumonitis in mice. / 06.2015 / PubMed / Full text
A mutation in the NADH-dehydrogenase subunit 2 suppresses fibroblast aging. / 20.04.2015 / PubMed / Full text
Anti-skin ageing activity of napthoquinones from Arnebia nobilis Reichb.f. / 2016 / PubMed / Full text
Altered neutrophil functions in elderly patients during a 6-month follow-up period after a hip fracture. / 05.2015 / PubMed / Full text
Age-associated oxidative modifications of mitochondrial α-subunit of F1 ATP synthase from mouse skeletal muscles. / 2015 / PubMed / Full text
Videofluoroscopic Validation of a Translational Murine Model of Presbyphagia. / 06.2015 / PubMed / Full text

COMT

The geriatric pain experience in mice: intact cutaneous thresholds but altered responses to tonic and chronic pain. / 05.2020 / PubMed / Full text
A candidate gene study of risk for dementia in older, postmenopausal women: Results from the Women's Health Initiative Memory Study. / 05.2019 / PubMed / Full text
Frontoparietal cortical thickness mediates the effect of COMT Val Met polymorphism on age-associated executive function. / 01.2019 / PubMed / Full text
[MELATONIN: THE POSSIBILITY TO ANALYSE THE MARKER OF AGE-RELATED PATHOLOGY IN THE BUCCAL EPITHELIUM AND URINE]. / 2017 / PubMed
The Moderating Role of COMT and BDNF Polymorphisms on Transfer Effects Following Multi- and Single-Domain Cognitive Training Among Community-Dwelling Shanghainese Older Adults. / 2018 / PubMed / Full text
Genetic Risk for Age-Related Cognitive Impairment Does Not Predict Cognitive Performance in Middle Age. / 2018 / PubMed / Full text
Dopamine-Related Genotypes and Physical Activity Change During an Intervention: The Lifestyle Interventions and Independence for Elders Study. / 07.2018 / PubMed / Full text
Genetic Biomarkers on Age-Related Cognitive Decline. / 2017 / PubMed / Full text
A genetic variant in the catechol-O-methyl transferase (COMT) gene is related to age-dependent differences in the therapeutic effect of calcium-channel blockers. / 07.2017 / PubMed / Full text
Catechol-O-Methyltransferase Genotype and Gait Speed Changes over 10 Years in Older Adults. / 09.2017 / PubMed / Full text
[Melatonin as a molecular marker of age-related pathologies]. / 2017 / PubMed
Chloroplast overexpression of rice caffeic acid O-methyltransferase increases melatonin production in chloroplasts via the 5-methoxytryptamine pathway in transgenic rice plants. / 08.2017 / PubMed / Full text
Age-dependent role of pre- and perinatal factors in interaction with genes on ADHD symptoms across adolescence. / 07.2017 / PubMed / Full text
Age differences in arterial and venous extra-cerebral blood flow in healthy adults: contributions of vascular risk factors and genetic variants. / 08.2017 / PubMed / Full text
Executive function performance and change in aging is predicted by apolipoprotein E, intensified by catechol-O-methyltransferase and brain-derived neurotrophic factor, and moderated by age and lifestyle. / 04.2017 / PubMed / Full text
Age-Dependent Effects of Catechol-O-Methyltransferase (COMT) Gene Val158Met Polymorphism on Language Function in Developing Children. / 01.01.2017 / PubMed / Full text
Aging and the genetic road towards the positivity effect in memory. / 09.2016 / PubMed / Full text
Older age may offset genetic influence on affect: The COMT polymorphism and affective well-being across the life span. / 05.2016 / PubMed / Full text
Differential effect of age on posterior and anterior hippocampal functional connectivity. / 06.2016 / PubMed / Full text
Pulse Pressure Magnifies the Effect of COMT Val(158)Met on 15 Years Episodic Memory Trajectories. / 2016 / PubMed / Full text
Modulative effects of COMT haplotype on age-related associations with brain morphology. / 06.2016 / PubMed / Full text
COMT Val158Met polymorphism is associated with blood pressure and lipid levels in general families of Bama longevous area in China. / 2015 / PubMed / Full text
Genetic Basis of the Relationship Between Reproduction and Longevity: A Study on Common Variants of Three Genes in Steroid Hormone Metabolism--CYP17, HSD17B1, and COMT. / 10.2015 / PubMed / Full text
Cognitive ability, intraindividual variability, and common genetic variants of catechol-O-methyltransferase and brain-derived neurotrophic factor: a longitudinal study in a population-based sample of older adults. / 06.2014 / PubMed / Full text
Healthy aging increases the cognitive effects of two genes that influence extracellular dopamine. / 06.2014 / PubMed / Full text
BDNF and COMT polymorphisms have a limited association with episodic memory performance or engagement in complex cognitive activity in healthy older adults. / 04.2014 / PubMed / Full text

LRRK2

Accelerated telomere shortening independent of LRRK2 variants in Chinese patients with Parkinson's disease. / 29.10.2020 / PubMed / Full text
The effect of LRRK2 loss-of-function variants in humans. / 06.2020 / PubMed / Full text
Parkinson's disease-related Leucine-rich repeat kinase 2 modulates nuclear morphology and genomic stability in striatal projection neurons during aging. / 19.02.2020 / PubMed / Full text
Autophagy and LRRK2 in the Aging Brain. / 2019 / PubMed / Full text
SerThr-PhosphoProteome of Brain from Aged PINK1-KO A53T-SNCA Mice Reveals pT1928-MAP1B and pS3781-ANK2 Deficits, as Hub between Autophagy and Synapse Changes. / 04.07.2019 / PubMed / Full text
Age-dependent accumulation of oligomeric SNCA/α-synuclein from impaired degradation in mutant LRRK2 knockin mouse model of Parkinson disease: role for therapeutic activation of chaperone-mediated autophagy (CMA). / 02.2020 / PubMed / Full text
A Neuron-Glial Trans-Signaling Cascade Mediates LRRK2-Induced Neurodegeneration. / 12.02.2019 / PubMed / Full text
Upregulation of the p53-p21 pathway by G2019S LRRK2 contributes to the cellular senescence and accumulation of α-synuclein. / 02.2019 / PubMed / Full text
G2019S LRRK2 mutation facilitates α-synuclein neuropathology in aged mice. / 12.2018 / PubMed / Full text
The Enzymatic Core of the Parkinson's Disease-Associated Protein LRRK2 Impairs Mitochondrial Biogenesis in Aging Yeast. / 2018 / PubMed / Full text
Age-related pathology after adenoviral overexpression of the leucine-rich repeat kinase 2 in the mouse striatum. / 06.2018 / PubMed / Full text
LRRK2 G2019S Induces Anxiety/Depression-like Behavior before the Onset of Motor Dysfunction with 5-HT Receptor Upregulation in Mice. / 14.02.2018 / PubMed / Full text
Age-Dependent Dopaminergic Neurodegeneration and Impairment of the Autophagy-Lysosomal Pathway in LRRK-Deficient Mice. / 15.11.2017 / PubMed / Full text
Initial elevations in glutamate and dopamine neurotransmission decline with age, as does exploratory behavior, in LRRK2 G2019S knock-in mice. / 20.09.2017 / PubMed / Full text
Suppression of neuroinflammation by matrix metalloproteinase-8 inhibitor in aged normal and LRRK2 G2019S Parkinson's disease model mice challenged with lipopolysaccharide. / 18.11.2017 / PubMed / Full text
Progression of pathology in PINK1-deficient mouse brain from splicing via ubiquitination, ER stress, and mitophagy changes to neuroinflammation. / 02.08.2017 / PubMed / Full text
Age-dependent dopamine transporter dysfunction and Serine129 phospho-α-synuclein overload in G2019S LRRK2 mice. / 14.03.2017 / PubMed / Full text
Combined LRRK2 mutation, aging and chronic low dose oral rotenone as a model of Parkinson's disease. / 18.01.2017 / PubMed / Full text
LRRK2 BAC transgenic rats develop progressive, L-DOPA-responsive motor impairment, and deficits in dopamine circuit function. / 01.03.2016 / PubMed / Full text
Functional and Morphological Correlates in the Drosophila LRRK2 loss-of-function Model of Parkinson's Disease: Drug Effects of Withania somnifera (Dunal) Administration. / 2016 / PubMed / Full text
G2019S LRRK2 and aging confer susceptibility to proteasome inhibitor-induced neurotoxicity in nigrostriatal dopaminergic system. / 12.2015 / PubMed / Full text
An early axonopathy in a hLRRK2(R1441G) transgenic model of Parkinson disease. / 10.2015 / PubMed / Full text
Mutations in LRRK2 potentiate age-related impairment of autophagic flux. / 11.07.2015 / PubMed / Full text
[11C]PBR28 PET imaging is sensitive to neuroinflammation in the aged rat. / 08.2015 / PubMed / Full text
Changes in actin dynamics and F-actin structure both in synaptoneurosomes of LRRK2(R1441G) mutant mice and in primary human fibroblasts of LRRK2(G2019S) mutation carriers. / 22.01.2015 / PubMed / Full text
Genetic and pharmacological evidence that G2019S LRRK2 confers a hyperkinetic phenotype, resistant to motor decline associated with aging. / 11.2014 / PubMed / Full text

MDM2

SENEBLOC, a long non-coding RNA suppresses senescence via p53-dependent and independent mechanisms. / 06.04.2020 / PubMed / Full text
Disruption of Robo2-Baiap2 integrated signaling drives cystic disease. / 19.09.2019 / PubMed / Full text
Senescence-induced immunophenotype, gene expression and electrophysiology changes in human amniocytes. / 11.2019 / PubMed / Full text
Hsp90β interacts with MDM2 to suppress p53-dependent senescence during skeletal muscle regeneration. / 10.2019 / PubMed / Full text
TZAP plays an inhibitory role in the self-renewal of porcine mesenchymal stromal cells and is implicated the regulation of premature senescence via the p53 pathway. / 07.03.2019 / PubMed / Full text
Synaptotagmin-7, a binding protein of P53, inhibits the senescence and promotes the tumorigenicity of lung cancer cells. / 28.02.2019 / PubMed / Full text
The SCF ubiquitin ligase complex mediates degradation of the tumor suppressor FBXO31 and thereby prevents premature cellular senescence. / 19.10.2018 / PubMed / Full text
The Dysfunctional MDM2-p53 Axis in Adipocytes Contributes to Aging-Related Metabolic Complications by Induction of Lipodystrophy. / 11.2018 / PubMed / Full text
Effect of CCNB1 silencing on cell cycle, senescence, and apoptosis through the p53 signaling pathway in pancreatic cancer. / 01.2018 / PubMed / Full text
Boosting ATM activity alleviates aging and extends lifespan in a mouse model of progeria. / 02.05.2018 / PubMed / Full text
Acute HSF1 depletion induces cellular senescence through the MDM2-p53-p21 pathway in human diploid fibroblasts. / 08.05.2018 / PubMed / Full text
Relevance of the p53-MDM2 axis to aging. / 01.2018 / PubMed / Full text
Pomegranate peel extract attenuates D-galactose-induced oxidative stress and hearing loss by regulating PNUTS/PP1 activity in the mouse cochlea. / 11.2017 / PubMed / Full text
Melatonin regulates the aging mouse hippocampal homeostasis via the sirtuin1-FOXO1 pathway. / 2017 / PubMed / Full text
Monitoring p53 by MDM2 and MDMX is required for endocrine pancreas development and function in a spatio-temporal manner. / 01.03.2017 / PubMed / Full text
Protection against High-Fat-Diet-Induced Obesity in MDM2 Mice Due to Reduced p53 Activity and Enhanced Energy Expenditure. / 24.01.2017 / PubMed / Full text
Pathways of aging: comparative analysis of gene signatures in replicative senescence and stress induced premature senescence. / 28.12.2016 / PubMed / Full text
Roles of TP53 in determining therapeutic sensitivity, growth, cellular senescence, invasion and metastasis. / 01.2017 / PubMed / Full text
Dynamics of ARF regulation that control senescence and cancer. / 11.2016 / PubMed / Full text
Breaking a paradigm: IL-6/STAT3 signaling suppresses metastatic prostate cancer upon ARF expression. / 03.2016 / PubMed / Full text
Combined therapies that induce senescence and stabilize p53 block melanoma growth and prompt antitumor immune responses. / 08.2015 / PubMed / Full text
BI2536--A PLK inhibitor augments paclitaxel efficacy in suppressing tamoxifen induced senescence and resistance in breast cancer cells. / 08.2015 / PubMed / Full text
NQO1 Stabilizes p53 in Response to Oncogene-Induced Senescence. / 2015 / PubMed / Full text
MDM2 turnover and expression of ATRX determine the choice between quiescence and senescence in response to CDK4 inhibition. / 10.04.2015 / PubMed / Full text
Senescence induction in renal carcinoma cells by Nutlin-3: a potential therapeutic strategy based on MDM2 antagonism. / 28.10.2014 / PubMed / Full text
Germline genetics of the p53 pathway affect longevity in a gender specific manner. / 2014 / PubMed / Full text

SIRT2

Melatonin ameliorates the advanced maternal age-associated meiotic defects in oocytes through the SIRT2-dependent H4K16 deacetylation pathway. / 24.01.2020 / PubMed / Full text
SIRT2 functions in aging, autophagy, and apoptosis in post-maturation bovine oocytes. / 01.09.2019 / PubMed / Full text
Lifelong Football Training: Effects on Autophagy and Healthy Longevity Promotion. / 2019 / PubMed / Full text
Mitochondrial Stress-Initiated Aberrant Activation of the NLRP3 Inflammasome Regulates the Functional Deterioration of Hematopoietic Stem Cell Aging. / 22.01.2019 / PubMed / Full text
Hsp90 Stabilizes SIRT1 Orthologs in Mammalian Cells and [i]C. elegans[/i]. / 20.11.2018 / PubMed / Full text
Tenovin-1 Induces Senescence and Decreases Wound-Healing Activity in Cultured Rat Primary Astrocytes. / 01.05.2019 / PubMed / Full text
High expression of CPT1b in skeletal muscle in metabolically healthy older subjects. / 04.2019 / PubMed / Full text
Expression of Sirtuins in the Retinal Neurons of Mice, Rats, and Humans. / 2017 / PubMed / Full text
Loss of SIRT2 leads to axonal degeneration and locomotor disability associated with redox and energy imbalance. / 12.2017 / PubMed / Full text
SIRT2 Acts as a Cardioprotective Deacetylase in Pathological Cardiac Hypertrophy. / 21.11.2017 / PubMed / Full text
Molecular evolutionary patterns of NAD /Sirtuin aging signaling pathway across taxa. / 2017 / PubMed / Full text
Sirtuins and Their Roles in Brain Aging and Neurodegenerative Disorders. / 03.2017 / PubMed / Full text
Resistance training and redox homeostasis: Correlation with age-associated genomic changes. / 12.2016 / PubMed / Full text
Aging-related 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-induced neurochemial and behavioral deficits and redox dysfunction: improvement by AK-7. / 09.2016 / PubMed / Full text
Increased expression of SIRT2 is a novel marker of cellular senescence and is dependent on wild type p53 status. / 17.07.2016 / PubMed / Full text
Effects of intrinsic aerobic capacity, aging and voluntary running on skeletal muscle sirtuins and heat shock proteins. / 15.06.2016 / PubMed / Full text
Sirtuins, Cell Senescence, and Vascular Aging. / 05.2016 / PubMed / Full text
The expression levels of the sirtuins in patients with BCC. / 05.2016 / PubMed / Full text
Effects of Aging and Cardiovascular Disease Risk Factors on the Expression of Sirtuins in the Human Corpus Cavernosum. / 11.2015 / PubMed / Full text
Localization of sirtuins (SIRT1-7) in the aged mouse inner ear. / 2016 / PubMed / Full text
Aging-related rotenone-induced neurochemical and behavioral deficits: role of SIRT2 and redox imbalance, and neuroprotection by AK-7. / 2015 / PubMed / Full text
Differential expression of sirtuins in the aging rat brain. / 2015 / PubMed / Full text
Polymorphisms Falling Within Putative miRNA Target Sites in the 3'UTR Region of SIRT2 and DRD2 Genes Are Correlated With Human Longevity. / 05.2016 / PubMed / Full text
The role of melatonin, sirtuin2 and FoXO1 transcription factor in the aging process of colon in male rats. / 02.2015 / PubMed / Full text
[[[SIRT2]], a multi-talented deacetylase]. / 05.2014 / PubMed / Full text
SIRT2 induces the checkpoint kinase BubR1 to increase lifespan. / 01.07.2014 / PubMed / Full text

APC

Differences between blacks and whites in well-being, beliefs, emotional states, behaviors and survival, 1978-2014. / 2020 / PubMed / Full text
Wnt-induced, TRP53-mediated Cell Cycle Arrest of Precursors Underlies Interstitial Cell of Cajal Depletion During Aging. / 07.08.2020 / PubMed / Full text
Burden of musculoskeletal disorders in Iran during 1990-2017: estimates from the Global Burden of Disease Study 2017. / 10.07.2020 / PubMed / Full text
Fall-related mortality trends in older Japanese adults aged ≥65 years: a nationwide observational study. / 11.12.2019 / PubMed / Full text
Stroke Mortality Rates and Trends in Romania, 1994-2017. / 12.2019 / PubMed / Full text
A new approach to quantifying the EEG during walking: Initial evidence of gait related potentials and their changes with aging and dual tasking. / 15.10.2019 / PubMed / Full text
Risk-period-cohort approach for averting identification problems in longitudinal models. / 2019 / PubMed / Full text
Wnt Signaling Mediates the Aging-Induced Differentiation Impairment of Intestinal Stem Cells. / 06.2019 / PubMed / Full text
Biased estimation of trends in cohort effects: the problems with age-period-cohort models in ecology. / 12.2018 / PubMed / Full text
[Gender Differences in Projected Life Expectancy in Japan (2023-2047) Determined by Bayesian Age-Period-Cohort Analysis]. / 2018 / PubMed / Full text
Activated Yes-Associated Protein Accelerates Cell Cycle, Inhibits Apoptosis, and Delays Senescence in Human Periodontal Ligament Stem Cells. / 2018 / PubMed / Full text
Activating the Anaphase Promoting Complex to Enhance Genomic Stability and Prolong Lifespan. / 27.06.2018 / PubMed / Full text
Effect of senescence marker protein 30 on the proliferation and apoptosis of human lens epithelial cells SRA01/04. / 2018 / PubMed / Full text
[Role and alterations of DNA methylation during the aging and cancer]. / 01.2018 / PubMed / Full text
MicroRNA-210-mediated proliferation, survival, and angiogenesis promote cardiac repair post myocardial infarction in rodents. / 12.2017 / PubMed / Full text
IL-6 Production by TLR-Activated APC Broadly Enhances Aged Cognate CD4 Helper and B Cell Antibody Responses In Vivo. / 01.04.2017 / PubMed / Full text
Standard expected years of life lost due to tuberculosis in Poland. / 01.02.2017 / PubMed / Full text
The effects of New York City's coordinated public health programmes on mortality through 2011. / 01.08.2017 / PubMed / Full text
Regional variation in coronary heart disease mortality trends in Portugal, 1981-2012. / 01.12.2016 / PubMed / Full text
Mitotic degradation of yeast Fkh1 by the Anaphase Promoting Complex is required for normal longevity, genomic stability and stress resistance. / 04.2016 / PubMed / Full text
Breast Cancer Trend in Iran from 2000 to 2009 and Prediction till 2020 using a Trend Analysis Method. / 2016 / PubMed / Full text
Secular trend analysis of lung cancer incidence in Sihui city, China between 1987 and 2011. / 31.07.2015 / PubMed / Full text
Black-white disparity in disability among U.S. older adults: age, period, and cohort trends. / 09.2014 / PubMed / Full text
Conserved mechanisms of tumorigenesis in the Drosophila adult midgut. / 2014 / PubMed / Full text
CD4 T cell defects in the aged: causes, consequences and strategies to circumvent. / 06.2014 / PubMed / Full text

CA2

Maintaining Aging Hippocampal Function with Safe and Feasible Shaking Exercise in SAMP10 Mice. / 2020 / PubMed / Full text
One-year Follow-up Study of Hippocampal Subfield Atrophy in Alzheimer's Disease and Normal Aging. / 2019 / PubMed / Full text
Maturation of PNN and ErbB4 Signaling in Area CA2 during Adolescence Underlies the Emergence of PV Interneuron Plasticity and Social Memory. / 29.10.2019 / PubMed / Full text
Early disruption of parvalbumin expression and perineuronal nets in the hippocampus of the Tg2576 mouse model of Alzheimer's disease can be rescued by enriched environment. / 12.2018 / PubMed / Full text
Protracted hippocampal development is associated with age-related improvements in memory during early childhood. / 01.07.2018 / PubMed / Full text
Neurodevelopment and behavior in neonatal OXYS rats with genetically determined accelerated senescence. / 15.02.2018 / PubMed / Full text
Effect of Chronic Administration of Resveratrol on Cognitive Performance during Aging Process in Rats. / 2017 / PubMed / Full text
Time of day but not aging regulates 5-HT receptor binding sites in the hamster hippocampus. / 01.01.2018 / PubMed / Full text
Cytoarchitectonically-driven MRI atlas of nonhuman primate hippocampus: Preservation of subfield volumes in aging. / 05.2019 / PubMed / Full text
Hippocampal sclerosis, hippocampal neuron loss patterns and TDP-43 in the aged population. / 07.2018 / PubMed / Full text
Aging Does Not Affect Axon Initial Segment Structure and Somatic Localization of Tau Protein in Hippocampal Neurons of Fischer 344 Rats. / 07-08.2017 / PubMed / Full text
Dancing or Fitness Sport? The Effects of Two Training Programs on Hippocampal Plasticity and Balance Abilities in Healthy Seniors. / 2017 / PubMed / Full text
Comparison of the influence of two models of mild stress on hippocampal brain-derived neurotrophin factor (BDNF) immunoreactivity in old age rats. / 2017 / PubMed / Full text
Protective effects of high Tryptophan diet on aging-induced passive avoidance impairment and hippocampal apoptosis. / 01.2017 / PubMed / Full text
Depressive symptoms modify age effects on hippocampal subfields in older adults. / 10.2017 / PubMed / Full text
Roles of hippocampal subfields in verbal and visual episodic memory. / 15.01.2017 / PubMed / Full text
Age-Dependent Specific Changes in Area CA2 of the Hippocampus and Social Memory Deficit in a Mouse Model of the 22q11.2 Deletion Syndrome. / 06.01.2016 / PubMed / Full text
Changes in serotonin (5-HT) and brain-derived neurotrophic factor (BDFN) expression in frontal cortex and hippocampus of aged rat treated with high tryptophan diet. / 10.2015 / PubMed / Full text
Hippocampal cytogenesis and spatial learning in senile rats exposed to chronic variable stress: effects of previous early life exposure to mild stress. / 2015 / PubMed / Full text
Longitudinal reproducibility of automatically segmented hippocampal subfields: A multisite European 3T study on healthy elderly. / 09.2015 / PubMed / Full text
Fluid percussion injury device for the precise control of injury parameters. / 15.06.2015 / PubMed / Full text
Characterization of Periodic Acid-Schiff-Positive Granular Deposits in the Hippocampus of SJL/J Mice. / 07.2015 / PubMed / Full text
Peripheral antioxidant markers are associated with total hippocampal and CA3/dentate gyrus volume in MDD and healthy controls-preliminary findings. / 30.12.2014 / PubMed / Full text
Hippocampal subfield volumes at 7T in early Alzheimer's disease and normal aging. / 09.2014 / PubMed / Full text
Moringa oleifera mitigates memory impairment and neurodegeneration in animal model of age-related dementia. / 2013 / PubMed / Full text

TLR2

Changes in salivary microbial sensing proteins CD14 and TLR2 with aging. / 07.2020 / PubMed / Full text
Culture Model for Non-human Primate Choroid Plexus. / 2019 / PubMed / Full text
Changes in fetal membrane histology with cervical insufficiency and transabdominal cerclage. / 08.2019 / PubMed / Full text
Aging leads to dysfunctional innate immune responses to TLR2 and TLR4 agonists. / 09.2019 / PubMed / Full text
The Synergy of Aging and LPS Exposure in a Mouse Model of Parkinson's Disease. / 10.2018 / PubMed / Full text
Aging modulates microglia phenotypes in neuroinflammation of MPTP-PD mice. / 01.10.2018 / PubMed / Full text
Toll-like receptor 2 deficiency hyperactivates the FoxO1 transcription factor and induces aging-associated cardiac dysfunction in mice. / 24.08.2018 / PubMed / Full text
Cryopreserved whole blood for the quantification of monocyte, T-cell and NK-cell subsets, and monocyte receptor expression by multi-color flow cytometry: A methodological study based on participants from the canadian longitudinal study on aging. / 05.2018 / PubMed / Full text
TLR4 and TLR2 activation is differentially associated with age during Parkinson's disease. / 01.2018 / PubMed / Full text
Role of pattern recognition receptors of the neurovascular unit in inflamm-aging. / 01.11.2017 / PubMed / Full text
Ionizing radiation reduces ADAM10 expression in brain microvascular endothelial cells undergoing stress-induced senescence. / 04.2017 / PubMed / Full text
Aging-related Atg5 defect impairs neutrophil extracellular traps formation. / 08.2017 / PubMed / Full text
Chronoinflammaging in Alzheimer; A systematic review on the roles of toll like receptor 2. / 15.02.2017 / PubMed / Full text
Aged B cells alter immune regulation of allografts in mice. / 11.2016 / PubMed / Full text
Estrogen receptors alpha mediates postischemic inflammation in chronically estrogen-deprived mice. / 04.2016 / PubMed / Full text
Effects of aerobic training on markers of autophagy in the elderly. / 04.2016 / PubMed / Full text
Reduced levels of cytosolic DNA sensor AIM2 are associated with impaired cytokine responses in healthy elderly. / 06.2016 / PubMed / Full text
Immune ageing and susceptibility to Streptococcus pneumoniae. / 06.2016 / PubMed / Full text
Monocyte Phenotype and Polyfunctionality Are Associated With Elevated Soluble Inflammatory Markers, Cytomegalovirus Infection, and Functional and Cognitive Decline in Elderly Adults. / 05.2016 / PubMed / Full text
Cathelicidin related antimicrobial peptide, laminin, Toll-like receptors and chemokines levels in experimental hypersensitivity pneumonitis in mice. / 06.2015 / PubMed / Full text
Prophylactic lithium alleviates splenectomy-induced cognitive dysfunction possibly by inhibiting hippocampal TLR4 activation in aged rats. / 05.2015 / PubMed / Full text
Altered neutrophil functions in elderly patients during a 6-month follow-up period after a hip fracture. / 05.2015 / PubMed / Full text
Aging does not affect the ability of human monocyte-derived dendritic cells to phagocytose Candida albicans. / 12.2015 / PubMed / Full text
Cardiac autonomic dysfunction: particulate air pollution effects are modulated by epigenetic immunoregulation of Toll-like receptor 2 and dietary flavonoid intake. / 27.01.2015 / PubMed / Full text
Bacteria and Toll-like receptor and cytokine mRNA expression profiles associated with canine arthritis. / 15.08.2014 / PubMed / Full text

AFM

Photocatalytic aging process of Nano-TiO coated polypropylene microplastics: Combining atomic force microscopy and infrared spectroscopy (AFM-IR) for nanoscale chemical characterization. / 15.02.2021 / PubMed / Full text
Nanoscale infrared, thermal and mechanical properties of aged microplastics revealed by an atomic force microscopy coupled with infrared spectroscopy (AFM-IR) technique. / 20.11.2020 / PubMed / Full text
Detecting zeta potential of polydimethylsiloxane (PDMS) in electrolyte solutions with atomic force microscope. / 15.10.2020 / PubMed / Full text
Recent Applications of Advanced Atomic Force Microscopy in Polymer Science: A Review. / 17.05.2020 / PubMed / Full text
Active fractions of mannoproteins derived from yeast cell wall stimulate innate and acquired immunity of adult and elderly dogs. / 03.2020 / PubMed / Full text
The Effect of Waste Engine Oil and Waste Polyethylene on UV Aging Resistance of Asphalt. / 06.03.2020 / PubMed / Full text
Mechanical properties measured by atomic force microscopy define health biomarkers in ageing C. elegans. / 25.02.2020 / PubMed / Full text
Nanomechanical insights: Amyloid beta oligomer-induced senescent brain endothelial cells. / 01.12.2019 / PubMed / Full text
Application of atomic force microscopy in the analysis of time since deposition (TSD) of red blood cells in bloodstains: A forensic analysis. / 08.2019 / PubMed / Full text
Iceland spar calcite: Humidity and time effects on surface properties and their reversibility. / 01.04.2019 / PubMed / Full text
Zebrafish as a model to study bone maturation: Nanoscale structural and mechanical characterization of age-related changes in the zebrafish vertebral column. / 08.2018 / PubMed / Full text
Multiscale Poroviscoelastic Compressive Properties of Mouse Supraspinatus Tendons Are Altered in Young and Aged Mice. / 01.05.2018 / PubMed / Full text
Proteomic Alterations Associated with Biomechanical Dysfunction are Early Processes in the Emilin1 Deficient Mouse Model of Aortic Valve Disease. / 11.2017 / PubMed / Full text
Effect of intra-oral aging on t→m phase transformation, microstructure, and mechanical properties of Y-TZP dental ceramics. / 08.2017 / PubMed / Full text
The Effect of Brushing and Aging on the Staining and Smoothness of Resin Composites. / 04.2017 / PubMed / Full text
Frequency-modulated atomic force microscopy localises viscoelastic remodelling in the ageing sheep aorta. / 12.2016 / PubMed / Full text
Changes in surface characteristics of two different resin composites after 1 year water storage: An SEM and AFM study. / 11.2016 / PubMed / Full text
Wide bandwidth nanomechanical assessment of murine cartilage reveals protection of aggrecan knock-in mice from joint-overuse. / 14.06.2016 / PubMed / Full text
Effect of at-home bleaching with different thickeners and aging on physical properties of a nanocomposite. / 01-03.2016 / PubMed / Full text
Interaction of intraocular lenses with fibronectin and human lens epithelial cells: Effect of chemical composition and aging. / 12.2015 / PubMed / Full text
β-Hydroxy-β-methylbutyrate (HMB) supplementation and resistance exercise significantly reduce abdominal adiposity in healthy elderly men. / 04.2015 / PubMed / Full text
Atomic force microscopy reveals age-dependent changes in nanomechanical properties of the extracellular matrix of native human menisci: implications for joint degeneration and osteoarthritis. / 11.2014 / PubMed / Full text
In situ atomic force microscopy analysis of morphology and particle size changes in lithium iron phosphate cathode during discharge. / 01.06.2014 / PubMed / Full text
Load cycling enhances bioactivity at the resin-dentin interface. / 07.2014 / PubMed / Full text

GSC

[i]mastermind[/i] regulates niche ageing independently of the [i]Notch[/i] pathway in the [i]Drosophila[/i] ovary. / 29.11.2019 / PubMed / Full text
Germline stem cell homeostasis. / 2019 / PubMed / Full text
Endocrine regulation of female germline stem cells in the fruit fly Drosophila melanogaster. / 02.2019 / PubMed / Full text
Generation of Inducible Gene-Switched GAL4 Expressed in the [i]Drosophila[/i] Female Germline Stem Cell Niche. / 05.06.2019 / PubMed / Full text
YAP/Yorkie in the germline modulates the age-related decline of germline stem cells and niche cells. / 2019 / PubMed / Full text
Diminished Jak/STAT Signaling Causes Early-Onset Aging Defects in Stem Cell Cytokinesis. / 21.01.2019 / PubMed / Full text
JNK signaling triggers spermatogonial dedifferentiation during chronic stress to maintain the germline stem cell pool in the [i]Drosophila[/i] testis. / 09.07.2018 / PubMed / Full text
Age-related differences in BOLD modulation to cognitive control costs in a multitasking paradigm: Global switch, local switch, and compatibility-switch costs. / 15.05.2018 / PubMed / Full text
Modelling glioblastoma tumour-host cell interactions using adult brain organotypic slice co-culture. / 22.02.2018 / PubMed / Full text
Loss of [i]foxo[/i] rescues stem cell aging in [i]Drosophila[/i] germ line. / 19.09.2017 / PubMed / Full text
DAF-18/PTEN signals through AAK-1/AMPK to inhibit MPK-1/MAPK in feedback control of germline stem cell proliferation. / 04.2017 / PubMed / Full text
Antithrombotic agents intake prior to injury does not affect outcome after a traumatic brain injury in hospitalized elderly patients. / 04.2017 / PubMed / Full text
Suberoylanilide hydroxamic acid represses glioma stem-like cells. / 18.11.2016 / PubMed / Full text
Flavonoids and darkness lower PCD in senescing Vitis vinifera suspension cell cultures. / 26.10.2016 / PubMed / Full text
DNA damage-induced Lok/CHK2 activation compromises germline stem cell self-renewal and lineage differentiation. / 01.12.2016 / PubMed / Full text
The Wnt pathway limits BMP signaling outside of the germline stem cell niche in Drosophila ovaries. / 01.09.2016 / PubMed / Full text
Nuclear hormone receptors as mediators of metabolic adaptability following reproductive perturbations. / 01-03.2016 / PubMed / Full text
Senescence from glioma stem cell differentiation promotes tumor growth. / 05.02.2016 / PubMed / Full text
Lipid-mediated regulation of SKN-1/Nrf in response to germ cell absence. / 24.08.2015 / PubMed / Full text
Microglial voltage-gated sodium channels modulate cellular response in Alzheimer's disease--a new perspective on an old problem. / 2015 / PubMed
Y-27632, a ROCK inhibitor, delays senescence of putative murine salivary gland stem cells in culture. / 06.2015 / PubMed / Full text
Notch signaling mediates the age-associated decrease in adhesion of germline stem cells to the niche. / 12.2014 / PubMed / Full text
Aging and insulin signaling differentially control normal and tumorous germline stem cells. / 02.2015 / PubMed / Full text
[The opportunity to use combined stem cells transplantation for haemopoesis activation in the old and mature laboratory animals under the conditions of ionizing radiation]. / 2014 / PubMed

HGF

Age-related changes in the immunomodulatory effects of human dental pulp derived mesenchymal stem cells on the CD4 T cell subsets. / 19.11.2020 / PubMed / Full text
Hepatocyte growth factor (HGF) and stem cell factor (SCF) maintained the stemness of human bone marrow mesenchymal stem cells (hBMSCs) during long-term expansion by preserving mitochondrial function via the PI3K/AKT, ERK1/2, and STAT3 signaling pathways. / 31.07.2020 / PubMed / Full text
Phenytoin sodium-ameliorated gingival fibroblast aging is associated with autophagy. / 10.2020 / PubMed / Full text
Impaired integrin α /β -mediated hepatocyte growth factor release by stellate cells of the aged liver. / 04.2020 / PubMed / Full text
Evaluation of the biological behaviour of various dental implant abutment materials on attachment and viability of human gingival fibroblasts. / 07.2019 / PubMed / Full text
Characterization of aged rat vocal fold fibroblasts. / 03.2019 / PubMed / Full text
Circulating Vascular Growth Factors and Magnetic Resonance Imaging Markers of Small Vessel Disease and Atrophy in Middle-Aged Adults. / 09.2018 / PubMed / Full text
Assessment of Human Skin Gene Expression by Different Blends of Plant Extracts with Implications to Periorbital Skin Aging. / 26.10.2018 / PubMed / Full text
Hepatocyte growth factor is a potential biomarker for osteoproliferation and osteoporosis in ankylosing spondylitis. / 02.2019 / PubMed / Full text
Human amniotic mesenchymal stem cells improve ovarian function in natural aging through secreting hepatocyte growth factor and epidermal growth factor. / 09.03.2018 / PubMed / Full text
HGF and BFGF Secretion by Human Adipose-Derived Stem Cells Improves Ovarian Function During Natural Aging via Activation of the SIRT1/FOXO1 Signaling Pathway. / 2018 / PubMed / Full text
Cell-size-dependent upregulation of HGF expression in dermal fibroblasts: Impact on human skin connective tissue aging. / 12.2017 / PubMed / Full text
Oxidative stress contributes to hepatocyte growth factor-dependent pro-senescence activity of ovarian cancer cells. / 09.2017 / PubMed / Full text
Estrogen modulates mesenchyme-epidermis interactions in the adult nipple. / 15.04.2017 / PubMed / Full text
Enhanced Functional Recovery from Spinal Cord Injury in Aged Mice after Stem Cell Transplantation through HGF Induction. / 14.03.2017 / PubMed / Full text
Necroptosis Induced by Ad-HGF Activates Endogenous C-Kit Cardiac Stem Cells and Promotes Cardiomyocyte Proliferation and Angiogenesis in the Infarcted Aged Heart. / 2016 / PubMed / Full text
Ovarian cancer-derived ascitic fluids induce a senescence-dependent pro-cancerogenic phenotype in normal peritoneal mesothelial cells. / 10.2016 / PubMed / Full text
Influence of aging on the quantity and quality of human cardiac stem cells. / 07.03.2016 / PubMed / Full text
Senescent peritoneal mesothelium induces a pro-angiogenic phenotype in ovarian cancer cells in vitro and in a mouse xenograft model in vivo. / 01.2016 / PubMed / Full text
Macrophage migration inhibitory factor confers resistance to senescence through CD74-dependent AMPK-FOXO3a signaling in mesenchymal stem cells. / 22.04.2015 / PubMed / Full text
Prevention of hair graying by factors that promote the growth and differentiation of melanocytes. / 08.2014 / PubMed / Full text
Low-power laser irradiation fails to improve liver regeneration in elderly rats at 48 h after 70 % resection. / 09.2015 / PubMed / Full text
Effect of AST on age-associated changes of vocal folds in a rat model. / 10.2014 / PubMed / Full text
The role of growth factors in maintenance of stemness in bone marrow-derived mesenchymal stem cells. / 28.02.2014 / PubMed / Full text

SOX2

Multiple nanosecond pulsed electric fields stimulation with conductive poly(l-lactic acid)/carbon nanotubes films maintains the multipotency of mesenchymal stem cells during prolonged in vitro culture. / 08.2020 / PubMed / Full text
Subpopulations of miniature pig mesenchymal stromal cells with different differentiation potentials differ in the expression of octamer-binding transcription factor 4 and sex determining region Y-box 2. / 03.2020 / PubMed / Full text
Increased Type I and Decreased Type II Hair Cells after Deletion of Sox2 in the Developing Mouse Utricle. / 01.12.2019 / PubMed / Full text
'Stemness' and 'senescence' related escape pathways are dose dependent in lung cancer cells surviving post irradiation. / 01.09.2019 / PubMed / Full text
Cellular senescence in progenitor cells contributes to diminished remyelination potential in progressive multiple sclerosis. / 30.04.2019 / PubMed / Full text
The senescent status of endothelial cells affects proliferation, inflammatory profile and SOX2 expression in bone marrow-derived mesenchymal stem cells. / 06.2019 / PubMed / Full text
Isolation, Characterization, and Differentiation of Cardiac Stem Cells from the Adult Mouse Heart. / 07.01.2019 / PubMed / Full text
A stably self-renewing adult blood-derived induced neural stem cell exhibiting patternability and epigenetic rejuvenation. / 02.10.2018 / PubMed / Full text
MicroRNA-338-5p plays a tumor suppressor role in glioma through inhibition of the MAPK-signaling pathway by binding to FOXD1. / 12.2018 / PubMed / Full text
Centenarians Overexpress Pluripotency-Related Genes. / 16.08.2019 / PubMed / Full text
MYC Releases Early Reprogrammed Human Cells from Proliferation Pause via Retinoblastoma Protein Inhibition. / 10.04.2018 / PubMed / Full text
SOX2 expression diminishes with ageing in several tissues in mice and humans. / 01.2019 / PubMed / Full text
Coupling shRNA screens with single-cell RNA-seq identifies a dual role for mTOR in reprogramming-induced senescence. / 15.10.2017 / PubMed / Full text
ZSCAN10 expression corrects the genomic instability of iPSCs from aged donors. / 09.2017 / PubMed / Full text
Induced Pluripotent Stem Cell-Derived Dopaminergic Neurons from Adult Common Marmoset Fibroblasts. / 01.09.2017 / PubMed / Full text
Role of p16 and BMI-1 in oxidative stress-induced premature senescence in human dental pulp stem cells. / 08.2017 / PubMed / Full text
Autophagic homeostasis is required for the pluripotency of cancer stem cells. / 02.2017 / PubMed / Full text
The p53 Pathway Controls SOX2-Mediated Reprogramming in the Adult Mouse Spinal Cord. / 11.10.2016 / PubMed / Full text
Sox2-Deficient Müller Glia Disrupt the Structural and Functional Maturation of the Mammalian Retina. / 03.2016 / PubMed / Full text
mTOR inhibition decreases SOX2-SOX9 mediated glioma stem cell activity and temozolomide resistance. / 2016 / PubMed / Full text
Disentangling the aneuploidy and senescence paradoxes: a study of triploid breast cancers non-responsive to neoadjuvant therapy. / 04.2016 / PubMed / Full text
Role of stress-activated OCT4A in the cell fate decisions of embryonal carcinoma cells treated with etoposide. / 2015 / PubMed / Full text
Critical role of the miR-200 family in regulating differentiation and proliferation of neurons. / 06.2015 / PubMed / Full text
Localization of juxtacrine factor ephrin-B2 in pituitary stem/progenitor cell niches throughout life. / 03.2015 / PubMed / Full text

BRAF

Conditional reprograming culture conditions facilitate growth of lower grade glioma models. / 01.12.2020 / PubMed / Full text
Active notch protects MAPK activated melanoma cell lines from MEK inhibitor cobimetinib. / 14.11.2020 / PubMed / Full text
Mitochondrial metabolic reprograming via BRAF inhibition ameliorates senescence. / 15.10.2019 / PubMed / Full text
Deciphering the genotype and phenotype of hairy cell leukemia: clues for diagnosis and treatment. / 08.2019 / PubMed / Full text
A clinical trial of somatic and germline analyses for healthy longevity in a postoperative cancer patient. / 09.2019 / PubMed / Full text
Aging-like Spontaneous Epigenetic Silencing Facilitates Wnt Activation, Stemness, and Braf -Induced Tumorigenesis. / 11.02.2019 / PubMed / Full text
Acquired resistance to BRAFi reverses senescence-like phenotype in mutant BRAF melanoma. / 07.08.2018 / PubMed / Full text
Cancer modeling by Transgene Electroporation in Adult Zebrafish (TEAZ). / 27.09.2018 / PubMed / Full text
Menopause and adipose tissue: miR-19a-3p is sensitive to hormonal replacement. / 05.01.2018 / PubMed / Full text
Impact of Age on Outcomes with Immunotherapy for Patients with Melanoma. / 08.2017 / PubMed / Full text
Establishment and application of a novel patient-derived KIAA1549:BRAF-driven pediatric pilocytic astrocytoma model for preclinical drug testing. / 14.02.2017 / PubMed / Full text
Detection of Reactive Oxygen Species in Cells Undergoing Oncogene-Induced Senescence. / 2017 / PubMed / Full text
GBM-associated mutations and altered protein expression are more common in young patients. / 25.10.2016 / PubMed / Full text
What makes oncogenes mutually exclusive? / 03.07.2017 / PubMed / Full text
Suppression of Type I Interferon Signaling Overcomes Oncogene-Induced Senescence and Mediates Melanoma Development and Progression. / 05.04.2016 / PubMed / Full text
Combination with γ-secretase inhibitor prolongs treatment efficacy of BRAF inhibitor in BRAF-mutated melanoma cells. / 28.06.2016 / PubMed / Full text
Parthenolide induces MITF-M downregulation and senescence in patient-derived MITF-M(high) melanoma cell populations. / 23.02.2016 / PubMed / Full text
Encorafenib (LGX818), a potent BRAF inhibitor, induces senescence accompanied by autophagy in BRAFV600E melanoma cells. / 28.01.2016 / PubMed / Full text
Novel Therapies for Metastatic Melanoma: An Update on Their Use in Older Patients. / 10.2015 / PubMed / Full text
Expression of tumor-related Rac1b antagonizes B-Raf-induced senescence in colorectal cells. / 28.12.2015 / PubMed / Full text
Trametinib radiosensitises RAS- and BRAF-mutated melanoma by perturbing cell cycle and inducing senescence. / 11.2015 / PubMed / Full text
Near-genomewide RNAi screening for regulators of BRAF(V600E) -induced senescence identifies RASEF, a gene epigenetically silenced in melanoma. / 07.2014 / PubMed / Full text
Oncogene-induced senescence distinguishes indolent from aggressive forms of pulmonary and non-pulmonary Langerhans cell histiocytosis. / 11.2014 / PubMed / Full text

CD36

Liver osteopontin is required to prevent the progression of age-related nonalcoholic fatty liver disease. / 08.2020 / PubMed / Full text
Reduction of senescence-associated beta-galactosidase activity by vitamin E in human fibroblasts depends on subjects' age and cell passage number. / 07.2020 / PubMed / Full text
Niacin-mediated rejuvenation of macrophage/microglia enhances remyelination of the aging central nervous system. / 05.2020 / PubMed / Full text
Human bone marrow adipocytes display distinct immune regulatory properties. / 08.2019 / PubMed / Full text
Expression of digestive enzyme and intestinal transporter genes during chronic heat stress in the thermally manipulated broiler chicken. / 01.09.2019 / PubMed / Full text
Pathophysiological significance of cylindromatosis in the vascular endothelium and macrophages for the initiation of age-related atherogenesis. / 22.01.2019 / PubMed / Full text
The adhesion and migration of microglia to β-amyloid (Aβ) is decreased with aging and inhibited by Nogo/NgR pathway. / 20.07.2018 / PubMed / Full text
Cell-surface phenotyping identifies CD36 and CD97 as novel markers of fibroblast quiescence in lung fibrosis. / 01.11.2018 / PubMed / Full text
An evolutionary transcriptomics approach links CD36 to membrane remodeling in replicative senescence. / 06.08.2018 / PubMed / Full text
Comparative analysis of endothelial cell and sub-endothelial cell elastic moduli in young and aged mice: Role of CD36. / 25.07.2018 / PubMed / Full text
CD36 initiates the secretory phenotype during the establishment of cellular senescence. / 06.2018 / PubMed / Full text
Senescence Alters PPARγ (Peroxisome Proliferator-Activated Receptor Gamma)-Dependent Fatty Acid Handling in Human Adipose Tissue Microvascular Endothelial Cells and Favors Inflammation. / 05.2018 / PubMed / Full text
Developmental differences between neonatal and adult human erythropoiesis. / 08.2018 / PubMed / Full text
Effects of high-fat diet and age on the blood lipidome and circulating endocannabinoids of female C57BL/6 mice. / 01.2018 / PubMed / Full text
Increased White Matter Inflammation in Aging- and Alzheimer's Disease Brain. / 2017 / PubMed / Full text
Thyroid hormone-stimulated increases in PGC-1α and UCP2 promote life history-specific endocrine changes and maintain a lipid-based metabolism. / 01.02.2017 / PubMed / Full text
The Drosophila CD36 Homologue croquemort Is Required to Maintain Immune and Gut Homeostasis during Development and Aging. / 10.2016 / PubMed / Full text
Distinct inflammatory phenotypes of microglia and monocyte-derived macrophages in Alzheimer's disease models: effects of aging and amyloid pathology. / 02.2017 / PubMed / Full text
Modulation of Macrophage Polarization and HMGB1-TLR2/TLR4 Cascade Plays a Crucial Role for Cardiac Remodeling in Senescence-Accelerated Prone Mice. / 2016 / PubMed / Full text
Impact of age and sex on the development of atherosclerosis and expression of the related genes in apoE deficient mice. / 15.01.2016 / PubMed / Full text
Effect of testosterone on markers of mitochondrial oxidative phosphorylation and lipid metabolism in muscle of aging men with subnormal bioavailable testosterone. / 07.2014 / PubMed / Full text
Increased hepatic CD36 expression with age is associated with enhanced susceptibility to nonalcoholic fatty liver disease. / 04.2014 / PubMed / Full text
Long-term vitamin E supplementation reduces atherosclerosis and mortality in Ldlr-/- mice, but not when fed Western style diet. / 03.2014 / PubMed / Full text

CIT

Effect of sex on aging-related decline of dopamine transporter in healthy subjects. / 14.10.2020 / PubMed / Full text
The Relationship Between the Striatal Dopaminergic Neuronal and Cognitive Function With Aging. / 2020 / PubMed / Full text
Initial Dietary Protein Intake Influence Muscle Function Adaptations in Older Men and Women Following High-Intensity Interval Training Combined with Citrulline. / 22.07.2019 / PubMed / Full text
I-FP-CIT striatal binding ratios do not decrease significantly with age in older adults. / 06.2019 / PubMed / Full text
Effect of High-Intensity Interval Training Combined with L-Citrulline Supplementation on Functional Capacities and Muscle Function in Dynapenic-Obese Older Adults. / 17.12.2018 / PubMed / Full text
The Six-Item Cognitive Impairment Test Is Associated with Adverse Outcomes in Acutely Hospitalized Older Patients: A Prospective Cohort Study. / 05-08.2018 / PubMed / Full text
Dopaminergic imaging separates normal pressure hydrocephalus from its mimics. / 10.2018 / PubMed / Full text
Lower Cognitive Function in Older Patients with Lower Muscle Strength and Muscle Mass. / 2018 / PubMed / Full text
Citrulline counteracts overweight- and aging-related effects on adiponectin and leptin gene expression in rat white adipose tissue. / 2015 / PubMed / Full text
Overcoming Barriers of Age to Enhance Efficacy of Cancer Immunotherapy: The Clout of the Extracellular Matrix. / 2018 / PubMed / Full text
Validation of the 6-Item Cognitive Impairment Test and the 4AT test for combined delirium and dementia screening in older Emergency Department attendees. / 01.01.2018 / PubMed / Full text
Octogenarian liver grafts: Is their use for transplant currently justified? / 07.05.2017 / PubMed / Full text
Citrulline stimulates locomotor activity in aged rats: Implication of the dopaminergic pathway. / 06.2017 / PubMed / Full text
Age-related effects and gender differences in Japanese healthy controls for [ I] FP-CIT SPECT. / 06.2017 / PubMed / Full text
The changes of individual carotid artery wall layer by aging and carotid intima-media thickness value for high risk. / 12.2016 / PubMed / Full text
Melodic Contour Identification Reflects the Cognitive Threshold of Aging. / 2016 / PubMed / Full text
Effects of Donor Age and Cold Ischemia on Liver Transplantation Outcomes According to the Severity of Recipient Status. / 02.2016 / PubMed / Full text
Aging and chronic administration of serotonin-selective reuptake inhibitor citalopram upregulate Sirt4 gene expression in the preoptic area of male mice. / 2015 / PubMed / Full text
Effects of aging and gender on striatal and extrastriatal [123I]FP-CIT binding in Parkinson's disease. / 04.2015 / PubMed / Full text
Dopamine transporter imaging in the aged rat: a [¹²³I]FP-CIT SPECT study. / 04.2015 / PubMed / Full text
Uneven age effects of [(18)F]FP-CIT binding in the striatum of Parkinson's disease. / 11.2014 / PubMed / Full text
Citrulline induces fatty acid release selectively in visceral adipose tissue from old rats. / 09.2014 / PubMed / Full text
Prognostic factors for kidney allograft survival in the Eurotransplant Senior Program. / 01.05.2014 / PubMed / Full text

DCX

GSK-3β activation accelerates early-stage consumption of Hippocampal Neurogenesis in senescent mice. / 2020 / PubMed / Full text
Doublecortin and IGF-1R protein levels are reduced in spite of unchanged DNA methylation in the hippocampus of aged rats. / 04.2020 / PubMed / Full text
Human Hippocampal Neurogenesis Persists in Aged Adults and Alzheimer's Disease Patients. / 06.06.2019 / PubMed / Full text
Age-related changes in Ki-67 and DCX expression in the BALB/ c mouse (Mus Musculus) brain. / 02.2019 / PubMed / Full text
Inflammation-induced Gro1 triggers senescence in neuronal progenitors: effects of estradiol. / 11.09.2018 / PubMed / Full text
Neuroprotective Effects of the Multitarget Agent AVCRI104P3 in Brain of Middle-Aged Mice. / 04.09.2018 / PubMed / Full text
Differential effects of adolescent and adult-initiated voluntary exercise on context and cued fear conditioning. / 02.2019 / PubMed / Full text
Hippocampal neurogenesis in the C57BL/6J mice at early adulthood following prenatal alcohol exposure. / 04.2018 / PubMed / Full text
Puerarin and Amlodipine Improvement of D-Galactose-Induced Impairments of Behaviour and Neurogenesis in Mouse Dentate Gyrus: Correlation with Glucocorticoid Receptor Expression. / 11.2017 / PubMed / Full text
Evidence for reduced neurogenesis in the aging human hippocampus despite stable stem cell markers. / 10.2017 / PubMed / Full text
Early-life decline in neurogenesis markers and age-related changes of TrkB splice variant expression in the human subependymal zone. / 07.2017 / PubMed / Full text
Dehydroepiandrosterone increases the number and dendrite maturation of doublecortin cells in the dentate gyrus of middle age male Wistar rats exposed to chronic mild stress. / 15.03.2017 / PubMed / Full text
Neurogenesis upregulation on the healthy hemisphere after stroke enhances compensation for age-dependent decrease of basal neurogenesis. / 03.2017 / PubMed / Full text
Postnatal maturation of mouse medullo-spinal cerebrospinal fluid-contacting neurons. / 20.02.2017 / PubMed / Full text
Topiramate Improves Neuroblast Differentiation of Hippocampal Dentate Gyrus in the D-Galactose-Induced Aging Mice via Its Antioxidant Effects. / 07.2017 / PubMed / Full text
Adenosine A1 receptor antagonist mitigates deleterious effects of sleep deprivation on adult neurogenesis and spatial reference memory in rats. / 19.11.2016 / PubMed / Full text
Sex-Specific Effects of Prenatal Stress on Memory and Markers of Neuronal Activity in Juvenile Rats. / 2016 / PubMed / Full text
MeHg Suppressed Neuronal Potency of Hippocampal NSCs Contributing to the Puberal Spatial Memory Deficits. / 08.2016 / PubMed / Full text
Hypercrosslinked Additives for Ageless Gas-Separation Membranes. / 05.02.2016 / PubMed / Full text
Fibroblast Growth Factor 14 Modulates the Neurogenesis of Granule Neurons in the Adult Dentate Gyrus. / 12.2016 / PubMed / Full text
Effects of Ginko biloba leaf extract on the neurogenesis of the hippocampal dentate gyrus in the elderly mice. / 06.2016 / PubMed / Full text
Persistent loss of hippocampal neurogenesis and increased cell death following adolescent, but not adult, chronic ethanol exposure. / 2014 / PubMed / Full text
Lactobacillus pentosus var. plantarum C29 ameliorates memory impairment and inflammaging in a D-galactose-induced accelerated aging mouse model. / 06.2014 / PubMed / Full text

F3

A Comprehensive Analysis of Age and Gender Effects in European Portuguese Oral Vowels. / 05.12.2020 / PubMed / Full text
Prenatal exposure to an environmentally relevant phthalate mixture accelerates biomarkers of reproductive aging in a multiple and transgenerational manner in female mice. / 28.10.2020 / PubMed / Full text
Combining Frontal Transcranial Direct Current Stimulation With Walking Rehabilitation to Enhance Mobility and Executive Function: A Pilot Clinical Trial. / 18.08.2020 / PubMed / Full text
Multigenerational exposure to TiO nanoparticles in soil stimulates stress resistance and longevity of survived C. elegans via activating insulin/IGF-like signaling. / 08.2020 / PubMed / Full text
Co-expression network analysis identified hub genes critical to triglyceride and free fatty acid metabolism as key regulators of age-related vascular dysfunction in mice. / 12.09.2019 / PubMed / Full text
Transgenerational Effects of Extended Dauer Diapause on Starvation Survival and Gene Expression Plasticity in [i]Caenorhabditis elegans[/i]. / 09.2018 / PubMed / Full text
Influence of Supplemental Protein on the Life Expectancy and Reproduction of the Chinese Citrus Fruit Fly, Bactrocera minax (Enderlein) (Tetradacus minax) (Diptera: Tephritidae). / 01.03.2018 / PubMed / Full text
Early-life exposure to three size-fractionated ultrafine and fine atmospheric particulates in Beijing exacerbates asthma development in mature mice. / 14.03.2018 / PubMed / Full text
Multigenerational effects of 4-methylbenzylidene camphor (4-MBC) on the survival, development and reproduction of the marine copepod Tigriopus japonicus. / 01.2018 / PubMed / Full text
Effects of Aging on Vocal Fundamental Frequency and Vowel Formants in Men and Women. / 09.2018 / PubMed / Full text
Shedding light on gray(ing) areas: Connectivity and task switching dynamics in aging. / 03.2018 / PubMed / Full text
Chronic exposure of zinc oxide nanoparticles causes deviant phenotype in Drosophila melanogaster. / 05.04.2017 / PubMed / Full text
Treatment of Chronic Hepatitis C in the Aged - Does It Impact Life Expectancy? A Decision Analysis. / 2016 / PubMed / Full text
Transgenerational programming of longevity and reproduction by post-eclosion dietary manipulation in Drosophila. / 05.2016 / PubMed / Full text
Spectrographic Acoustic Vocal Characteristics of Elderly Women Engaged in Aerobics. / 09.2016 / PubMed / Full text
Fat and carbohydrate intake over three generations modify growth, metabolism and cardiovascular phenotype in female mice in an age-related manner. / 2015 / PubMed / Full text
Effect of semolina-jaggery diet on survival and development of Drosophila melanogaster. / 2015 / PubMed / Full text
Differential regulation of apoptosis in slow and fast twitch muscles of aged female F344BN rats. / 2015 / PubMed / Full text
Dexmedetomidine and regulation of splenic sympathetic nerve discharge in aged F344 rats. / 07.2015 / PubMed / Full text
Comprehensive analysis of the ubiquitinome during oncogene-induced senescence in human fibroblasts. / 2015 / PubMed / Full text
Docosahexaenoic acid in Arctic charr (Salvelinus alpinus): the importance of dietary supply and physiological response during the entire growth period. / 03.2015 / PubMed / Full text
Starvation-induced transgenerational inheritance of small RNAs in C. elegans. / 17.07.2014 / PubMed / Full text
Air pollution and gene-specific methylation in the Normative Aging Study: association, effect modification, and mediation analysis. / 03.2014 / PubMed / Full text

GHR

Tissue-Specific GHR Knockout Mice: An Updated Review. / 2020 / PubMed / Full text
The mir-465 family is upregulated with age and attenuates growth hormone signaling in mouse liver. / 04.2019 / PubMed / Full text
Growth hormone during in vitro fertilization in older women modulates the density of receptors in granulosa cells, with improved pregnancy outcomes. / 12.2018 / PubMed / Full text
Effects of rapamycin on growth hormone receptor knockout mice. / 13.02.2018 / PubMed / Full text
Disruption of the GH receptor gene in adult mice and in insulin sensitive tissues. / 02.2018 / PubMed / Full text
The GH receptor exon 3 deletion is a marker of male-specific exceptional longevity associated with increased GH sensitivity and taller stature. / 06.2017 / PubMed / Full text
Differential effects of early-life nutrient restriction in long-lived GHR-KO and normal mice. / 06.2017 / PubMed / Full text
Brain Structure and Function Associated with Younger Adults in Growth Hormone Receptor-Deficient Humans. / 15.02.2017 / PubMed / Full text
Enhanced Cognition and Hypoglutamatergic Signaling in a Growth Hormone Receptor Knockout Mouse Model of Successful Aging. / 01.03.2017 / PubMed / Full text
Growth hormone receptor expression in human gluteal versus abdominal subcutaneous adipose tissue: Association with body shape. / 05.2016 / PubMed / Full text
The somatotropic axis and aging: Benefits of endocrine defects. / 04.2016 / PubMed / Full text
Growth factors, aging and age-related diseases. / 06.2016 / PubMed / Full text
Correlation Analysis Between Expression Levels of Hepatic Growth Hormone Receptor, Janus Kinase 2, Insulin-Like Growth Factor-I Genes and Dwarfism Phenotype in Bama Minipig. / 02.2015 / PubMed / Full text
Growth hormone modulates hypothalamic inflammation in long-lived pituitary dwarf mice. / 12.2015 / PubMed / Full text
Removal of growth hormone receptor (GHR) in muscle of male mice replicates some of the health benefits seen in global GHR-/- mice. / 07.2015 / PubMed / Full text
Gene expression of key regulators of mitochondrial biogenesis is sex dependent in mice with growth hormone receptor deletion in liver. / 03.2015 / PubMed / Full text
Conservation of pro-longevity genes among mammals. / 03.2015 / PubMed / Full text
Interaction of growth hormone receptor/binding protein gene disruption and caloric restriction for insulin sensitivity and attenuated aging. / 2014 / PubMed / Full text
Inflammatory and Glutamatergic Homeostasis Are Involved in Successful Aging. / 03.2016 / PubMed / Full text
Specific suppression of insulin sensitivity in growth hormone receptor gene-disrupted (GHR-KO) mice attenuates phenotypic features of slow aging. / 12.2014 / PubMed / Full text
Molecular evolution of growth hormone and insulin-like growth factor 1 receptors in long-lived, small-bodied mammals. / 10.10.2014 / PubMed / Full text
Low protein intake is associated with a major reduction in IGF-1, cancer, and overall mortality in the 65 and younger but not older population. / 04.03.2014 / PubMed / Full text
Expression of apoptosis-related genes in liver-specific growth hormone receptor gene-disrupted mice is sex dependent. / 01.2015 / PubMed / Full text

VDR

25-Hydroxyvitamin D positively regulates periodontal inflammaging via SOCS3/STAT signaling in diabetic mice. / 04.2020 / PubMed / Full text
1,25-Dihydroxyvitamin D protects against age-related osteoporosis by a novel VDR-Ezh2-p16 signal axis. / 02.2020 / PubMed / Full text
Active vitamin D impedes the progression of non-alcoholic fatty liver disease by inhibiting cell senescence in a rat model. / 09.2020 / PubMed / Full text
Age-dependent expression of the vitamin D receptor and the protective effect of vitamin D receptor activation on H O -induced apoptosis in rat intervertebral disc cells. / 06.2019 / PubMed / Full text
Vitamin D Receptor in Muscle Atrophy of Elderly Patients: A Key Element of Osteoporosis-Sarcopenia Connection. / 12.2018 / PubMed / Full text
Reduced vitamin D receptor (VDR) expression and plasma vitamin D levels are associated with aging-related prostate lesions. / 05.2018 / PubMed / Full text
VDR Activation Reduces Proteinuria and High-Glucose-Induced Injury of Kidneys and Podocytes by Regulating Wnt Signaling Pathway. / 2017 / PubMed / Full text
Vitamin D and the brain: Genomic and non-genomic actions. / 15.09.2017 / PubMed / Full text
Targeted next generation sequencing of the entire vitamin D receptor gene reveals polymorphisms correlated with vitamin D deficiency among older Filipino women with and without fragility fracture. / 03.2017 / PubMed / Full text
Using Hyperpolarized Xe MRI to Quantify the Pulmonary Ventilation Distribution. / 12.2016 / PubMed / Full text
Lead-Related Genetic Loci, Cumulative Lead Exposure and Incident Coronary Heart Disease: The Normative Aging Study. / 2016 / PubMed / Full text
Relationship between cardiometabolic profile, vitamin D status and BsmI polymorphism of the VDR gene in non-institutionalized elderly subjects: Cardiometabolic profile, vitamin D status and BsmI polymorphism of the VDR gene in non-institutionalized elderly subjects. / 08.2016 / PubMed / Full text
Impact of vitamin D receptor polymorphisms in centenarians. / 08.2016 / PubMed / Full text
Aging and a long-term diabetes mellitus increase expression of 1 α-hydroxylase and vitamin D receptors in the rat liver. / 12.2015 / PubMed / Full text
Nuclear hormone receptors: Roles of xenobiotic detoxification and sterol homeostasis in healthy aging. / 2015 / PubMed / Full text
Vitamin D Receptor Ablation and Vitamin D Deficiency Result in Reduced Grip Strength, Altered Muscle Fibers, and Increased Myostatin in Mice. / 12.2015 / PubMed / Full text
Extra-intestinal calcium handling contributes to normal serum calcium levels when intestinal calcium absorption is suboptimal. / 12.2015 / PubMed / Full text
Vitamin D Receptor Genotype Modulates the Correlation between Vitamin D and Circulating Levels of let-7a/b and Vitamin D Intake in an Elderly Cohort. / 2014 / PubMed / Full text
Vitamin D, muscle and bone: Integrating effects in development, aging and injury. / 15.07.2015 / PubMed / Full text
Association between vitamin D concentration and levels of sex hormones in an elderly Polish population with different genotypes of VDR polymorphisms (rs10735810, rs1544410, rs7975232, rs731236). / 15.03.2015 / PubMed / Full text
Effect modification by vitamin D receptor genetic polymorphisms in the association between cumulative lead exposure and pulse pressure: a longitudinal study. / 13.01.2015 / PubMed / Full text
Vitamin D receptor and megalin gene polymorphisms are associated with central adiposity status and changes among US adults. / 2013 / PubMed / Full text
Vitamin D signaling in myogenesis: potential for treatment of sarcopenia. / 2014 / PubMed / Full text

EZH2

Linking gene expression and phenotypic changes in the developmental and evolutionary origins of osteosclerosis in the ribs of bowhead whales (Balaena mysticetus). / 09.2020 / PubMed / Full text
EZH2 is involved in vulnerability to neuroinflammation and depression-like behaviors induced by chronic stress in different aged mice. / 01.07.2020 / PubMed / Full text
A positive feedback loop between EZH2 and NOX4 regulates nucleus pulposus cell senescence in age-related intervertebral disc degeneration. / 2020 / PubMed / Full text
Perinatal exposure to bisphenol A impacts in the mammary gland morphology of adult Mongolian gerbils. / 04.2020 / PubMed / Full text
Long noncoding RNA MALAT1 potentiates growth and inhibits senescence by antagonizing ABI3BP in gallbladder cancer cells. / 07.06.2019 / PubMed / Full text
Epigenetic Co-Deregulation of EZH2/TET1 is a Senescence-Countering, Actionable Vulnerability in Triple-Negative Breast Cancer. / 2019 / PubMed / Full text
Improving Treatment for Myelodysplastic Syndromes Patients. / 25.10.2018 / PubMed / Full text
Aging Suppresses Skin-Derived Circulating SDF1 to Promote Full-Thickness Tissue Regeneration. / 25.09.2018 / PubMed / Full text
Epigallocatechin-3-gallate and BIX-01294 have different impact on epigenetics and senescence modulation in acute and chronic myeloid leukemia cells. / 05.11.2018 / PubMed / Full text
Selective molecular biomarkers to predict biologic behavior in pituitary tumors. / 05.2017 / PubMed / Full text
Regulation of Cellular Senescence by Polycomb Chromatin Modifiers through Distinct DNA Damage- and Histone Methylation-Dependent Pathways. / 27.03.2018 / PubMed / Full text
Region specific knock-out reveals distinct roles of chromatin modifiers in adult neurogenic niches. / 2018 / PubMed / Full text
Conserved effect of aging on DNA methylation and association with EZH2 polycomb protein in mice and humans. / 03.2017 / PubMed / Full text
The Ubiquitin-like with PHD and Ring Finger Domains 1 (UHRF1)/DNA Methyltransferase 1 (DNMT1) Axis Is a Primary Regulator of Cell Senescence. / 03.03.2017 / PubMed / Full text
Enhancer of Zeste Homolog 2 and Histone Deacetylase 9c Regulate Age-Dependent Mesenchymal Stem Cell Differentiation into Osteoblasts and Adipocytes. / 08.2016 / PubMed / Full text
Insight into the molecular pathophysiology of myelodysplastic syndromes: targets for novel therapy. / 10.2016 / PubMed / Full text
HBP1-mediated Regulation of p21 Protein through the Mdm2/p53 and TCF4/EZH2 Pathways and Its Impact on Cell Senescence and Tumorigenesis. / 10.06.2016 / PubMed / Full text
New concept: cellular senescence in pathophysiology of cholangiocarcinoma. / 2016 / PubMed / Full text
SIRT1 affects DNA methylation of polycomb group protein target genes, a hotspot of the epigenetic shift observed in ageing. / 24.06.2015 / PubMed / Full text
Enhancer of zeste homolog 2 depletion induces cellular senescence via histone demethylation along the INK4/ARF locus. / 08.2015 / PubMed / Full text
Polycomb repressive complex 2 epigenomic signature defines age-associated hypermethylation and gene expression changes. / 2015 / PubMed / Full text
Luotonin-A based quinazolinones cause apoptosis and senescence via HDAC inhibition and activation of tumor suppressor proteins in HeLa cells. / 13.04.2015 / PubMed / Full text

MAPT

Association of relative brain age with tobacco smoking, alcohol consumption, and genetic variants. / 30.01.2020 / PubMed / Full text
A blood-based nutritional risk index explains cognitive enhancement and decline in the multidomain Alzheimer prevention trial. / 2019 / PubMed / Full text
Longitudinal associations of physical activity levels with morphological and functional changes related with aging: The MAPT study. / 12.2019 / PubMed / Full text
Ageing and amyloidosis underlie the molecular and pathological alterations of tau in a mouse model of familial Alzheimer's disease. / 31.10.2019 / PubMed / Full text
Revisiting the intersection of amyloid, pathologically modified tau and iron in Alzheimer's disease from a ferroptosis perspective. / 01.2020 / PubMed / Full text
Factors associated with changes of the frailty status after age 70: Findings in the MAPT study. / 06.2019 / PubMed / Full text
Mitophagy and NAD inhibit Alzheimer disease. / 06.2019 / PubMed / Full text
Cognitive changes of older adults with an equivocal amyloid load. / 04.2019 / PubMed / Full text
Tauopathy: A common mechanism for neurodegeneration and brain aging. / 03.2019 / PubMed / Full text
Cinnamaldehyde Improves Lifespan and Healthspan in [i]Drosophila melanogaster[/i] Models for Alzheimer's Disease. / 2018 / PubMed / Full text
Sex and age interact to determine clinicopathologic differences in Alzheimer's disease. / 12.2018 / PubMed / Full text
Effects of a 3-Year Multi-Domain Intervention with or without Omega-3 Supplementation on Cognitive Functions in Older Subjects with Increased CAIDE Dementia Scores. / 2018 / PubMed / Full text
Whole-Exome Sequencing of an Exceptional Longevity Cohort. / 16.08.2019 / PubMed / Full text
Interaction between a MAPT variant causing frontotemporal dementia and mutant APP affects axonal transport. / 08.2018 / PubMed / Full text
Evaluating the Patterns of Aging-Related Tau Astrogliopathy Unravels Novel Insights Into Brain Aging and Neurodegenerative Diseases. / 01.04.2017 / PubMed / Full text
CSF protein changes associated with hippocampal sclerosis risk gene variants highlight impact of GRN/PGRN. / 04.2017 / PubMed / Full text
Koolen-de Vries Syndrome: Clinical Report of an Adult and Literature Review. / 2016 / PubMed / Full text
Presymptomatic cognitive decline in familial frontotemporal dementia: A longitudinal study. / 26.07.2016 / PubMed / Full text
Frontotemporal dementia: insights into the biological underpinnings of disease through gene co-expression network analysis. / 24.02.2016 / PubMed / Full text
Cellular and molecular modifier pathways in tauopathies: the big picture from screening invertebrate models. / 04.2016 / PubMed / Full text
Drosophila models of Alzheimer's disease: advances, limits, and perspectives. / 2015 / PubMed / Full text
Association between MAPT haplotype and memory function in patients with Parkinson's disease and healthy aging individuals. / 03.2015 / PubMed / Full text

MBP

Demyelination associated with chronic arsenic exposure in Wistar rats. / 15.04.2020 / PubMed / Full text
Natural killer cells as participants in pathogenesis of rat experimental autoimmune encephalomyelitis (EAE): lessons from research on rats with distinct age and strain. / 2019 / PubMed / Full text
Whey protein concentrate supplementation protects rat brain against aging-induced oxidative stress and neurodegeneration. / 05.2018 / PubMed / Full text
Strain specificities in age-related changes in mechanisms promoting and controlling rat spinal cord damage in experimental autoimmune encephalomyelitis. / 01.2018 / PubMed / Full text
Age-dependent differences in myelin basic protein expression in the hippocampus of young, adult and aged gerbils. / 09.2017 / PubMed / Full text
Schwann Cell Phenotype Changes in Aging Human Dental Pulp. / 03.2018 / PubMed / Full text
Blood pressure reactivity to mental stress is attenuated following resistance exercise in older hypertensive women. / 2017 / PubMed / Full text
Higher levels of myelin phospholipids in brains of neuronal α-Synuclein transgenic mice precede myelin loss. / 08.05.2017 / PubMed / Full text
Traffic-related air pollution impact on mouse brain accelerates myelin and neuritic aging changes with specificity for CA1 neurons. / 05.2017 / PubMed / Full text
Postnatal alteration of monocarboxylate transporter 1 expression in the rat corpus callosum. / 04.05.2017 / PubMed / Full text
Bowel Preparation Is Associated with Reduced Morbidity in Elderly Patients Undergoing Elective Colectomy. / 02.2017 / PubMed / Full text
Myelin Basic Protein Regulates Primitive and Definitive Neural Stem Cell Proliferation from the Adult Spinal Cord. / 02.2017 / PubMed / Full text
Isoaspartic acid is present at specific sites in myelin basic protein from multiple sclerosis patients: could this represent a trigger for disease onset? / 12.08.2016 / PubMed / Full text
Generation of a LacZ reporter transgenic mouse line for the stereological analysis of oligodendrocyte loss in galactosylceramidase deficiency. / 12.2016 / PubMed / Full text
Loss of Hippocampal Oligodendrocytes Contributes to the Deficit of Contextual Fear Learning in Adult Rats Experiencing Early Bisphenol A Exposure. / 08.2017 / PubMed / Full text
Aging diminishes the resistance of AO rats to EAE: putative role of enhanced generation of GM-CSF Expressing CD4 T cells in aged rats. / 2015 / PubMed / Full text
Sleeve Gastrectomy Decreases Body Weight, Whole-Body Adiposity, and Blood Pressure Even in Aged Diet-Induced Obese Rats. / 07.2016 / PubMed / Full text
Classic and Golli Myelin Basic Protein have distinct developmental trajectories in human visual cortex. / 2015 / PubMed / Full text
Defective renal dopamine function and sodium-sensitive hypertension in adult ovariectomized Wistar rats: role of the cytochrome P-450 pathway. / 15.06.2015 / PubMed / Full text
White matter injury and microglia/macrophage polarization are strongly linked with age-related long-term deficits in neurological function after stroke. / 10.2015 / PubMed / Full text
Age-related changes in spleen of Dark Agouti rats immunized for experimental autoimmune encephalomyelitis. / 15.01.2015 / PubMed / Full text
Phase separation of myelin sheath in Triton X-114 solution: predominant localization of the 21.5-kDa isoform of myelin basic protein in the lipid raft-associated domain. / 04.2014 / PubMed / Full text

PAH

Changes in light absorption by brown carbon in soot particles due to heterogeneous ozone aging in a smog chamber. / 11.2020 / PubMed / Full text
Factors associated with pulmonary arterial hypertension (PAH) in systemic sclerosis (SSc). / 09.2020 / PubMed / Full text
Potentially Avoidable Hospitalization among Long-Term Care Insurance Beneficiaries with Dementia. / 09.2020 / PubMed / Full text
Burden of disease at the same limit of exposure to airborne polycyclic aromatic hydrocarbons varies significantly across countries depending on the gap in longevity. / 30.09.2019 / PubMed / Full text
Converging Paths of Pulmonary Arterial Hypertension and Cellular Senescence. / 07.2019 / PubMed / Full text
Furanoflavones pongapin and lanceolatin B blocks the cell cycle and induce senescence in CYP1A1-overexpressing breast cancer cells. / 15.12.2018 / PubMed / Full text
Exposure to Polycyclic Aromatic Hydrocarbons and Accelerated DNA Methylation Aging. / 06.2018 / PubMed / Full text
Arrhythmias in adult patients with congenital heart disease and pulmonary arterial hypertension. / 12.2018 / PubMed / Full text
Reduced bioavailability and plant uptake of polycyclic aromatic hydrocarbons from soil slurry amended with biochars pyrolyzed under various temperatures. / 06.2018 / PubMed / Full text
Early-life exposure to three size-fractionated ultrafine and fine atmospheric particulates in Beijing exacerbates asthma development in mature mice. / 14.03.2018 / PubMed / Full text
Changes of total and freely dissolved polycyclic aromatic hydrocarbons and toxicity of biochars treated with various aging processes. / 06.2018 / PubMed / Full text
Bioaccessibility of PAHs and PAH derivatives in a fuel soot assessed by an in vitro digestive model with absorptive sink: Effects of aging the soot in a soil-water mixture. / 15.02.2018 / PubMed / Full text
Airborne polycyclic aromatic hydrocarbons trigger human skin cells aging through aryl hydrocarbon receptor. / 01.07.2017 / PubMed / Full text
DNA integrity-protecting and survival-promoting activity of serotonergic system in sturgeon juveniles and sazans. / 08.2017 / PubMed / Full text
Disruption of phenylalanine hydroxylase reduces adult lifespan and fecundity, and impairs embryonic development in parthenogenetic pea aphids. / 03.10.2016 / PubMed / Full text
Hepatic Responses of Juvenile Fundulus heteroclitus from Pollution-adapted and Nonadapted Populations Exposed to Elizabeth River Sediment Extract. / 07.2016 / PubMed / Full text
Non-muscle myosin light chain promotes endothelial progenitor cells senescence and dysfunction in pulmonary hypertensive rats through up-regulation of NADPH oxidase. / 15.03.2016 / PubMed / Full text
Maintaining lung health with longstanding HIV. / 02.2016 / PubMed / Full text
Selective enhancement of endothelial BMPR-II with BMP9 reverses pulmonary arterial hypertension. / 07.2015 / PubMed / Full text
Pulmonary arterial hypertension in rats due to age-related arginase activation in intermittent hypoxia. / 08.2015 / PubMed / Full text
Symptom Prevalence, Symptom Severity, and Health-Related Quality of Life Among Young, Middle, and Older Adults With Pulmonary Arterial Hypertension. / 04.2016 / PubMed / Full text
Plasma concentrations of tadalafil in children with pulmonary arterial hypertension. / 10.2014 / PubMed / Full text

TST

H S Donors Reverse Age-Related Gastric Malfunction Impaired Due to Fructose-Induced Injury [i]via[/i] CBS, CSE, and TST Expression. / 2020 / PubMed / Full text
Adaptations in mechanical muscle function, muscle morphology, and aerobic power to high-intensity endurance training combined with either traditional or power strength training in older adults: a randomized clinical trial. / 05.2020 / PubMed / Full text
Digital phenotyping by consumer wearables identifies sleep-associated markers of cardiovascular disease risk and biological aging. / 2019 / PubMed / Full text
Objective Sleep Duration in Older Adults: Results From The Irish Longitudinal Study on Ageing. / 01.2020 / PubMed / Full text
Subjective Cognitive Decline and Nighttime Sleep Alterations, a Longitudinal Analysis. / 2019 / PubMed / Full text
Validity Evaluation of the Fitbit Charge2 and the Garmin vivosmart HR in Free-Living Environments in an Older Adult Cohort. / 19.06.2019 / PubMed / Full text
Paradoxical effect of testosterone supplementation therapy on cardiac ischemia/reperfusion injury in aged rats. / 07.2019 / PubMed / Full text
Sleep Disturbances and Risk of Hospitalization and Inpatient Days Among Older Women. / 01.04.2017 / PubMed / Full text
Relationships between [i]FTO[/i] rs9939609, [i]MC4R[/i] rs17782313, and [i]PPARγ[/i] rs1801282 polymorphisms and the occurrence of selected metabolic and hormonal disorders in middle-aged and elderly men - a preliminary study. / 2016 / PubMed / Full text
Rest-Activity Patterns in Older Adults with Heart Failure and Healthy Older Adults. / 01.2017 / PubMed / Full text
The impact of BCG vaccination on tuberculin skin test responses in children is age dependent: evidence to be considered when screening children for tuberculosis infection. / 10.2016 / PubMed / Full text
The relation between polysomnography and subjective sleep and its dependence on age - poor sleep may become good sleep. / 10.2016 / PubMed / Full text
Association between physiological falls risk and physical performance tests among community-dwelling older adults. / 2015 / PubMed / Full text
Anthropometric reference data for elderly Swedes and its disease-related pattern. / 09.2015 / PubMed / Full text
Impact of maternal melatonin suppression on forced swim and tail suspension behavioral despair tests in adult offspring. / 04-06.2015 / PubMed / Full text
Controversies in testosterone supplementation therapy. / 03-04.2015 / PubMed / Full text
Diagnosis and management of testosterone deficiency. / 03-04.2015 / PubMed / Full text
Testosterone replacement therapy: who to evaluate, what to use, how to follow, and who is at risk? / 12.2014 / PubMed / Full text
An Overview of Testosterone Therapy. / 01.2016 / PubMed / Full text
Associations of objectively and subjectively measured sleep quality with subsequent cognitive decline in older community-dwelling men: the MrOS sleep study. / 01.04.2014 / PubMed / Full text
Chronotype, bed timing and total sleep time in seniors. / 06.2014 / PubMed / Full text
Telomere length is associated with sleep duration but not sleep quality in adults with human immunodeficiency virus. / 01.01.2014 / PubMed / Full text

BAX

Clearance of therapy-induced senescent tumor cells by the senolytic ABT-263 via interference with BCL-X -BAX interaction. / 10.2020 / PubMed / Full text
CREB Signaling Mediates Dose-Dependent Radiation Response in the Murine Hippocampus Two Years after Total Body Exposure. / 03.01.2020 / PubMed / Full text
Reduced sucrose nonfermenting AMPK-related kinase (SNARK) activity aggravates cancer-induced skeletal muscle wasting. / 09.2019 / PubMed / Full text
Modulated electro-hyperthermia induced p53 driven apoptosis and cell cycle arrest additively support doxorubicin chemotherapy of colorectal cancer in vitro. / 08.2019 / PubMed / Full text
The Clearance Effect of Tetrahedral DNA Nanostructures on Senescent Human Dermal Fibroblasts. / 16.01.2019 / PubMed / Full text
Premature placental aging in term small-for-gestational-age and growth-restricted fetuses. / 05.2019 / PubMed / Full text
Regulation of apoptosis and autophagy in mouse and human skeletal muscle with aging and lifelong exercise training. / 01.10.2018 / PubMed / Full text
Xanthohumol exerts protective effects in liver alterations associated with aging. / 03.2019 / PubMed / Full text
Protective effect of xanthohumol against age-related brain damage. / 11.2017 / PubMed / Full text
[Inula Britannica flower total flavonoids reduces the apoptosis of aging bone marrow mesenchymal stem cells by anti-oxidation]. / 05.2017 / PubMed
Hilar granule cells of the mouse dentate gyrus: effects of age, septotemporal location, strain, and selective deletion of the proapoptotic gene BAX. / 09.2017 / PubMed / Full text
p16 enhances the transcriptional and the apoptotic functions of p53 through DNA-dependent interaction. / 07.2017 / PubMed / Full text
Protective effects of high Tryptophan diet on aging-induced passive avoidance impairment and hippocampal apoptosis. / 01.2017 / PubMed / Full text
Mechanisms of Heshouwuyin in regulating apoptosis of testicular cells in aging rats through mitochondrial pathway. / 01.09.2016 / PubMed / Full text
Response of BAX, Bcl-2 Proteins, and SIRT1/PGC-1α mRNA Expression to 8-Week Treadmill Running in the Aging Rat Skeletal Muscle. / 2016 / PubMed / Full text
Sperm-associated antigen 9 (SPAG9) promotes the survival and tumor growth of triple-negative breast cancer cells. / 10.2016 / PubMed / Full text
Apoptosis in young and old denervated rat skeletal muscle. / 02.2017 / PubMed / Full text
Amelioration of neuronal cell death in a spontaneous obese rat model by dietary restriction through modulation of ubiquitin proteasome system. / 07.2016 / PubMed / Full text
Melatonin decreases the expression of inflammation and apoptosis markers in the lung of a senescence-accelerated mice model. / 03.2016 / PubMed / Full text
Melatonin Counteracts at a Transcriptional Level the Inflammatory and Apoptotic Response Secondary to Ischemic Brain Injury Induced by Middle Cerebral Artery Blockade in Aging Rats. / 2015 / PubMed / Full text
The effect of aging on mitochondrial and cytosolic hepatic intrinsic death pathway and apoptosis associated proteins in Fischer 344 rats. / 07.2015 / PubMed / Full text

CCR2

Hip Fracture Leads to Transitory Immune Imprint in Older Patients. / 2020 / PubMed / Full text
The CC-chemokine receptor 2 is involved in the control of ovarian folliculogenesis and fertility lifespan in mice. / 09.2020 / PubMed / Full text
Deficit of resolution receptor magnifies inflammatory leukocyte directed cardiorenal and endothelial dysfunction with signs of cardiomyopathy of obesity. / 08.2020 / PubMed / Full text
Tet2-mediated clonal hematopoiesis in nonconditioned mice accelerates age-associated cardiac dysfunction. / 26.03.2020 / PubMed / Full text
Inflammation and Ectopic Fat Deposition in the Aging Murine Liver Is Influenced by CCR2. / 02.2020 / PubMed / Full text
Klotho-mediated targeting of CCL2 suppresses the induction of colorectal cancer progression by stromal cell senescent microenvironments. / 11.2019 / PubMed / Full text
Aging induces cardiac mesenchymal stromal cell senescence and promotes endothelial cell fate of the CD90 subset. / 10.2019 / PubMed / Full text
Commensal bacteria contribute to insulin resistance in aging by activating innate B1a cells. / 14.11.2018 / PubMed / Full text
Persistent Infiltration and Impaired Response of Peripherally-Derived Monocytes after Traumatic Brain Injury in the Aged Brain. / 30.05.2018 / PubMed / Full text
Cryopreserved whole blood for the quantification of monocyte, T-cell and NK-cell subsets, and monocyte receptor expression by multi-color flow cytometry: A methodological study based on participants from the canadian longitudinal study on aging. / 05.2018 / PubMed / Full text
Inhibition of Radiation-Induced Ccl2 Signaling Protects Lungs from Vascular Dysfunction and Endothelial Cell Loss. / 10.01.2019 / PubMed / Full text
Attenuated Macrophage Infiltration in Glomeruli of Aged Mice Resulting in Ameliorated Kidney Injury in Nephrotoxic Serum Nephritis. / 10.08.2018 / PubMed / Full text
Distinct Functions of Senescence-Associated Immune Responses in Liver Tumor Surveillance and Tumor Progression. / 10.10.2016 / PubMed / Full text
Absence of CCR2 results in an inflammaging environment in young mice with age-independent impairments in muscle regeneration. / 11.2016 / PubMed / Full text
Long-lived self-renewing bone marrow-derived macrophages displace embryo-derived cells to inhabit adult serous cavities. / 13.06.2016 / PubMed / Full text
Age exacerbates the CCR2/5-mediated neuroinflammatory response to traumatic brain injury. / 18.04.2016 / PubMed / Full text
Enhanced Ccl2-Ccr2 signaling drives more severe choroidal neovascularization with aging. / 04.2016 / PubMed / Full text
Alterations in Monocyte Phenotypes and Functions after a Hip Fracture in Elderly Individuals: A 6-Month Longitudinal Study. / 2016 / PubMed / Full text
TNF Drives Monocyte Dysfunction with Age and Results in Impaired Anti-pneumococcal Immunity. / 01.2016 / PubMed / Full text
Senescent dermal fibroblasts enhance stem cell migration through CCL2/CCR2 axis. / 07.2015 / PubMed / Full text
Differential expression of monocyte surface markers among TB patients with diabetes co-morbidity. / 12.2013 / PubMed / Full text

CD40

The Regulatory Status Adopted by Lymph Node Dendritic Cells and T Cells During Healthy Aging Is Maintained During Cancer and May Contribute to Reduced Responses to Immunotherapy. / 2018 / PubMed / Full text
Age-Related Changes on CD40 Promotor Methylation and Immune Gene Expressions in Thymus of Chicken. / 2018 / PubMed / Full text
Macrophage Depletion in Elderly Mice Improves Response to Tumor Immunotherapy, Increases Anti-tumor T Cell Activity and Reduces Treatment-Induced Cachexia. / 2018 / PubMed / Full text
One-Year Consumption of a Mediterranean-Like Dietary Pattern With Vitamin D3 Supplements Induced Small Scale but Extensive Changes of Immune Cell Phenotype, Co-receptor Expression and Innate Immune Responses in Healthy Elderly Subjects: Results From the United Kingdom Arm of the NU-AGE Trial. / 2018 / PubMed / Full text
Membrane-Bound CD40L Promotes Senescence and Initiates Senescence-Associated Secretory Phenotype via NF-κB Activation in Lung Adenocarcinoma. / 2018 / PubMed / Full text
Effects of Immunosenescence on the Lower Expression of Surface Molecules in Neutrophils and Lymphocytes. / 2018 / PubMed / Full text
Aerobic Exercise Protects from Pseudomonas aeruginosa-Induced Pneumonia in Elderly Mice. / 2018 / PubMed / Full text
Elderly dendritic cells respond to LPS/IFN-γ and CD40L stimulation despite incomplete maturation. / 2018 / PubMed / Full text
C-Reactive Protein Impairs Dendritic Cell Development, Maturation, and Function: Implications for Peripheral Tolerance. / 2018 / PubMed / Full text
Immunoglobulin therapy ameliorates the phenotype and increases lifespan in the severely affected dystrophin-utrophin double knockout mice. / 12.2017 / PubMed / Full text
Age-Associated B Cells Express a Diverse Repertoire of V and Vκ Genes with Somatic Hypermutation. / 01.03.2017 / PubMed / Full text
Autoimmune manifestations in aged mice arise from early-life immune dysregulation. / 19.10.2016 / PubMed / Full text
The age-related neuroinflammatory environment promotes macrophage activation, which negatively impacts synaptic function. / 07.2016 / PubMed / Full text
Combinatorial approach to cancer immunotherapy: strength in numbers. / 08.2016 / PubMed / Full text
Human mesothelioma induces defects in dendritic cell numbers and antigen-processing function which predict survival outcomes. / 02.2016 / PubMed / Full text
Skewing of peritoneal resident macrophages toward M1-like is involved in enhancement of inflammatory responses induced by secondary necrotic neutrophils in aged mice. / 06-07.2016 / PubMed / Full text
Blood-borne biomarkers of mortality risk: systematic review of cohort studies. / 2015 / PubMed / Full text
Age-associated modifications of intestinal permeability and innate immunity in human small intestine. / 10.2015 / PubMed / Full text
Obesity superimposed on aging magnifies inflammation and delays the resolving response after myocardial infarction. / 15.02.2015 / PubMed / Full text
Maturation of innate responses to mycobacteria over the first nine months of life. / 15.05.2014 / PubMed / Full text
IL-2/CD40-activated macrophages rescue age and tumor-induced T cell dysfunction in elderly mice. / 06.2014 / PubMed / Full text

ELOVL2

ELOVL2: Not just a biomarker of aging. / 2020 / PubMed / Full text
The lipid elongation enzyme ELOVL2 is a molecular regulator of aging in the retina. / 02.2020 / PubMed / Full text
Human aging DNA methylation signatures are conserved but accelerated in cultured fibroblasts. / 10.2019 / PubMed / Full text
Cell and tissue type independent age-associated DNA methylation changes are not rare but common. / 27.11.2018 / PubMed / Full text
DNA methylation of the ELOVL2, FHL2, KLF14, C1orf132/MIR29B2C, and TRIM59 genes for age prediction from blood, saliva, and buccal swab samples. / 01.2019 / PubMed / Full text
Proof of concept study of age-dependent DNA methylation markers across different tissues by massive parallel sequencing. / 09.2018 / PubMed / Full text
Age-related DNA methylation changes are tissue-specific with ELOVL2 promoter methylation as exception. / 30.05.2018 / PubMed / Full text
DNA methylation levels in candidate genes associated with chronological age in mammals are not conserved in a long-lived seabird. / 2017 / PubMed / Full text
Chronological age prediction based on DNA methylation: Massive parallel sequencing and random forest regression. / 11.2017 / PubMed / Full text
DNA methylation in ELOVL2 and C1orf132 correctly predicted chronological age of individuals from three disease groups. / 01.2018 / PubMed / Full text
Independent validation of DNA-based approaches for age prediction in blood. / 07.2017 / PubMed / Full text
Genome-wide DNA methylation analysis reveals hypomethylation in the low-CpG promoter regions in lymphoblastoid cell lines. / 12.05.2017 / PubMed / Full text
Systemic Age-Associated DNA Hypermethylation of ELOVL2 Gene: In Vivo and In Vitro Evidences of a Cell Replication Process. / 01.08.2017 / PubMed / Full text
Donor age and C1orf132/MIR29B2C determine age-related methylation signature of blood after allogeneic hematopoietic stem cell transplantation. / 2016 / PubMed / Full text
Forensic age prediction for dead or living samples by use of methylation-sensitive high resolution melting. / 07.2016 / PubMed / Full text
Development of a methylation marker set for forensic age estimation using analysis of public methylation data and the Agena Bioscience EpiTYPER system. / 09.2016 / PubMed / Full text
Age-associated changes in DNA methylation across multiple tissues in an inbred mouse model. / 03.2016 / PubMed / Full text
Aging-associated DNA methylation changes in middle-aged individuals: the Young Finns study. / 09.02.2016 / PubMed / Full text
Improved age determination of blood and teeth samples using a selected set of DNA methylation markers. / 2015 / PubMed / Full text
Development of a forensically useful age prediction method based on DNA methylation analysis. / 07.2015 / PubMed / Full text
Genome-wide age-related changes in DNA methylation and gene expression in human PBMCs. / 06.2014 / PubMed / Full text

REST

[Brain and Neuronal Aging: Aged Brain Controls via Gene Expression Fidelity and Master Regulatory Factors]. / 2020 / PubMed / Full text
Effect of 9 - PAHSA on cognitive dysfunction in diabetic mice and its possible mechanism. / 09.04.2020 / PubMed / Full text
Increased REST to Optimize Life Span? / 12.2019 / PubMed / Full text
Cardiac baroreflex hysteresis is one of the determinants of the heart period variability asymmetry. / 01.10.2019 / PubMed / Full text
Pterostilbene Improves Cognitive Performance in Aged Rats: An in Vivo Study. / 2019 / PubMed / Full text
Comparison between probabilistic and Wiener-Granger causality in assessing modifications of the cardiac baroreflex control with age. / 22.10.2018 / PubMed / Full text
Fast-Evolving Human-Specific Neural Enhancers Are Associated with Aging-Related Diseases. / 23.05.2018 / PubMed / Full text
Influence of age and gender on the phase and strength of the relation between heart period and systolic blood pressure spontaneous fluctuations. / 01.03.2018 / PubMed / Full text
Genetic Biomarkers on Age-Related Cognitive Decline. / 2017 / PubMed / Full text
MicroRNA Expression Analysis of Centenarians and Rheumatoid Arthritis Patients Reveals a Common Expression Pattern. / 2017 / PubMed / Full text
The rs1277306 Variant of the REST Gene Confers Susceptibility to Cognitive Aging in an Elderly Taiwanese Population. / 2017 / PubMed / Full text
Assessing the evolution of redundancy/synergy of spontaneous variability regulation with age. / 05.2017 / PubMed / Full text
Sixty years old is the breakpoint of human frontal cortex aging. / 02.2017 / PubMed / Full text
Is senescence-associated β-galactosidase a marker of neuronal senescence? / 06.12.2016 / PubMed / Full text
Running for REST: Physical activity attenuates neuroinflammation in the hippocampus of aged mice. / 03.2017 / PubMed / Full text
Hippocampal proteomics defines pathways associated with memory decline and resilience in normal aging and Alzheimer's disease mouse models. / 30.03.2017 / PubMed / Full text
A gain-of-function senescence bypass screen identifies the homeobox transcription factor DLX2 as a regulator of ATM-p53 signaling. / 01.02.2016 / PubMed / Full text
An integrative multi-scale analysis of the dynamic DNA methylation landscape in aging. / 02.2015 / PubMed / Full text
MicroRNA-9 controls dendritic development by targeting REST. / 18.11.2014 / PubMed / Full text
Rcor2 underexpression in senescent mice: a target for inflammaging? / 23.07.2014 / PubMed / Full text
REST and stress resistance in ageing and Alzheimer's disease. / 27.03.2014 / PubMed / Full text

SIRT7

SIRT7 antagonizes human stem cell aging as a heterochromatin stabilizer. / 07.2020 / PubMed / Full text
Spatio-temporal expression profile of sirtuins during aging of the annual fish Nothobranchius furzeri. / 09.2019 / PubMed / Full text
Advances in Cellular Characterization of the Sirtuin Isoform, SIRT7. / 2018 / PubMed / Full text
The epigenetic regulator SIRT7 guards against mammalian cellular senescence induced by ribosomal DNA instability. / 13.07.2018 / PubMed / Full text
Differential gene expression of sirtuins between somatotropinomas and nonfunctioning pituitary adenomas. / 08.2018 / PubMed / Full text
Analysis of Polymorphisms in 59 Potential Candidate Genes for Association With Human Longevity. / 08.10.2018 / PubMed / Full text
The effects of graded levels of calorie restriction: XI. Evaluation of the main hypotheses underpinning the life extension effects of CR using the hepatic transcriptome. / 31.07.2017 / PubMed / Full text
Sirtuin 7 is decreased in pulmonary fibrosis and regulates the fibrotic phenotype of lung fibroblasts. / 01.06.2017 / PubMed / Full text
The protein-interaction network with functional roles in tumorigenesis, neurodegeneration, and aging. / 12.2016 / PubMed / Full text
Molecular, Cellular, and Physiological Characterization of Sirtuin 7 (SIRT7). / 2016 / PubMed / Full text
miR-152 induces human dental pulp stem cell senescence by inhibiting SIRT7 expression. / 04.2016 / PubMed / Full text
Sirtuins, Cell Senescence, and Vascular Aging. / 05.2016 / PubMed / Full text
The expression levels of the sirtuins in patients with BCC. / 05.2016 / PubMed / Full text
Age-Related Changes in Sirtuin 7 Expression in Calorie-Restricted and Refed Rats. / 2016 / PubMed / Full text
Effects of Aging and Cardiovascular Disease Risk Factors on the Expression of Sirtuins in the Human Corpus Cavernosum. / 11.2015 / PubMed / Full text
Novel protein-protein interactions of TPPII, p53, and SIRT7. / 11.2015 / PubMed / Full text
Differential expression of sirtuins in the aging rat brain. / 2015 / PubMed / Full text
Stressed SIRT7: facing a crossroad of senescence and immortality. / 06.2015 / PubMed / Full text
Sirtuin 7 promotes cellular survival following genomic stress by attenuation of DNA damage, SAPK activation and p53 response. / 01.02.2015 / PubMed / Full text
A SIRT7-dependent acetylation switch of GABPβ1 controls mitochondrial function. / 04.11.2014 / PubMed / Full text
Comparative interactomes of SIRT6 and SIRT7: Implication of functional links to aging. / 07.2014 / PubMed / Full text

TEC

Vestibular function and cortical and sub-cortical alterations in an aging population. / 08.2020 / PubMed / Full text
Metabolic Flexibility and Innate Immunity in Renal Ischemia Reperfusion Injury: The Fine Balance Between Adaptive Repair and Tissue Degeneration. / 2020 / PubMed / Full text
Postnatal Involution and Counter-Involution of the Thymus. / 2020 / PubMed / Full text
Gender Disparity Impacts on Thymus Aging and LHRH Receptor Antagonist-Induced Thymic Reconstitution Following Chemotherapeutic Damage. / 2020 / PubMed / Full text
Clonogenic Culture of Mouse Thymic Epithelial Cells. / 2019 / PubMed / Full text
TREM1/3 Deficiency Impairs Tissue Repair After Acute Kidney Injury and Mitochondrial Metabolic Flexibility in Tubular Epithelial Cells. / 2019 / PubMed / Full text
Interplay between Follistatin, Activin A, and BMP4 Signaling Regulates Postnatal Thymic Epithelial Progenitor Cell Differentiation during Aging. / 25.06.2019 / PubMed / Full text
Transgenic Exosomes for Thymus Regeneration. / 2019 / PubMed / Full text
Cell-type-specific role of lamin-B1 in thymus development and its inflammation-driven reduction in thymus aging. / 08.2019 / PubMed / Full text
Comparison of the Shear Bond Strength of Metal Orthodontic Brackets Bonded to Long-term Water-aged and Fresh Porcelain and Composite Surfaces. / 03.2019 / PubMed / Full text
Epithelial innate immunity mediates tubular cell senescence after kidney injury. / 24.01.2019 / PubMed / Full text
Thymic Epithelial Cell Support of Thymopoiesis Does Not Require [i]Klotho[/i]. / 01.12.2018 / PubMed / Full text
MicroRNAs Regulate Thymic Epithelium in Age-Related Thymic Involution via Down- or Upregulation of Transcription Factors. / 2017 / PubMed / Full text
A Fine-Tune Role of Mir-125a-5p on [i]Foxn1[/i] During Age-Associated Changes in the Thymus. / 05.2017 / PubMed / Full text
Mechanisms and kinetics of proliferation and fibrosis development in a mouse model of thyrocyte hyperplasia. / 06-07.2016 / PubMed / Full text
Foxn1 Is Dynamically Regulated in Thymic Epithelial Cells during Embryogenesis and at the Onset of Thymic Involution. / 2016 / PubMed / Full text
Foxn1 Protein Expression in the Developing, Aging, and Regenerating Thymus. / 15.12.2015 / PubMed / Full text
Young, proliferative thymic epithelial cells engraft and function in aging thymuses. / 15.05.2015 / PubMed / Full text
Regeneration of the aged thymus by a single transcription factor. / 04.2014 / PubMed / Full text
Meis1 is required for the maintenance of postnatal thymic epithelial cells. / 2014 / PubMed / Full text
Identification of novel thymic epithelial cell subsets whose differentiation is regulated by RANKL and Traf6. / 2014 / PubMed / Full text

C6

Evolution of the Aroma of Treixadura Wines during Bottle Aging. / 08.10.2020 / PubMed / Full text
D-galactose induces senescence of glioblastoma cells through YAP-CDK6 pathway. / 29.09.2020 / PubMed / Full text
Alcohol Extracts From [i]Ganoderma lucidum[/i] Delay the Progress of Alzheimer's Disease by Regulating DNA Methylation in Rodents. / 2019 / PubMed / Full text
Age and Sex-Associated Changes of Complement Activity and Complement Levels in a Healthy Caucasian Population. / 2018 / PubMed / Full text
Population-Stratified Analysis of Bone Mineral Density Distribution in Cervical and Lumbar Vertebrae of Chinese from Quantitative Computed Tomography. / 09-10.2016 / PubMed / Full text
Demographic aspects in cervical vertebral bodies' size and shape (C3-C7): a skeletal study. / 01.2017 / PubMed / Full text
Neonatal Benzo[a]pyrene Exposure Induces Oxidative Stress and DNA Damage Causing Neurobehavioural Changes during the Early Adolescence Period in Rats. / 2016 / PubMed / Full text
Variations in Occipitocervical and Cervicothoracic Alignment Parameters Based on Age: A Prospective Study of Asymptomatic Volunteers Using Full-Body Radiographs. / 01.12.2016 / PubMed / Full text
Age-related brain atrophy may be mitigated by internal jugular vein enlargement in male individuals without neurologic disease. / 03.2017 / PubMed / Full text
The incidence of cervical spondylosis decreases with aging in the elderly, and increases with aging in the young and adult population: a hospital-based clinical analysis. / 2016 / PubMed / Full text
Depletion of B cell CLL/Lymphoma 11B Gene Expression Represses Glioma Cell Growth. / 08.2016 / PubMed / Full text
Are the standard parameters of cervical spine alignment and range of motion related to age, sex, and cervical disc degeneration? / 09.2015 / PubMed / Full text
Age-related morphologic changes of the vertebral artery in the transverse process. Analysis by multidetector computed tomography angiography. / 01.09.2015 / PubMed / Full text
Role of the serotonin transporter gene locus in the response to SSRI treatment of major depressive disorder in late life. / 05.2015 / PubMed / Full text
The Impact of Genetics on Physical Resilience and Successful Aging. / 09.2015 / PubMed / Full text
Intake of low-dose leucine-rich essential amino acids stimulates muscle anabolism equivalently to bolus whey protein in older women at rest and after exercise. / 15.06.2015 / PubMed / Full text
Non-sirtuin histone deacetylases in the control of cardiac aging. / 06.2015 / PubMed / Full text
Engineering temporal accumulation of a low recalcitrance polysaccharide leads to increased C6 sugar content in plant cell walls. / 09.2015 / PubMed / Full text
The effects of age on the morphometry of the cervical spinal cord and spinal column in adult rats: an MRI-based study. / 10.2014 / PubMed / Full text
Spontaneous age-related cervical disc degeneration in the sand rat. / 06.2014 / PubMed / Full text

C7

The Vertebral Artery Convergence to the Cervical Spine in Elders. / 30.09.2019 / PubMed / Full text
Age-related Changes in Cervical Sagittal Alignment: A Radiographic Analysis. / 01.10.2019 / PubMed / Full text
Early Intravenous Infusion of Mesenchymal Stromal Cells Exerts a Tissue Source Age-Dependent Beneficial Effect on Neurovascular Integrity and Neurobehavioral Recovery After Traumatic Cervical Spinal Cord Injury. / 07.2019 / PubMed / Full text
Age and Sex-Associated Changes of Complement Activity and Complement Levels in a Healthy Caucasian Population. / 2018 / PubMed / Full text
Twenty-year Longitudinal Follow-up MRI Study of Asymptomatic Volunteers: The Impact of Cervical Alignment on Disk Degeneration. / 12.2018 / PubMed / Full text
The change of cervical spine alignment along with aging in asymptomatic population: a preliminary analysis. / 09.2017 / PubMed / Full text
Lumbar Retrolisthesis in Aging Spine: What are the Associated Factors? / 07.2017 / PubMed / Full text
Three types of sagittal alignment regarding compensation in asymptomatic adults: the contribution of the spine and lower limbs. / 02.2018 / PubMed / Full text
Age-related variations in global spinal alignment and sagittal balance in asymptomatic Japanese adults. / 05.2017 / PubMed / Full text
Standing sagittal alignment of the whole axial skeleton with reference to the gravity line in humans. / 05.2017 / PubMed / Full text
Population-Stratified Analysis of Bone Mineral Density Distribution in Cervical and Lumbar Vertebrae of Chinese from Quantitative Computed Tomography. / 09-10.2016 / PubMed / Full text
Demographic aspects in cervical vertebral bodies' size and shape (C3-C7): a skeletal study. / 01.2017 / PubMed / Full text
Prediction of Cervical Endplate Size: One Size Does Not Fit All. / 01.05.2016 / PubMed / Full text
Variations in Occipitocervical and Cervicothoracic Alignment Parameters Based on Age: A Prospective Study of Asymptomatic Volunteers Using Full-Body Radiographs. / 01.12.2016 / PubMed / Full text
Age-related brain atrophy may be mitigated by internal jugular vein enlargement in male individuals without neurologic disease. / 03.2017 / PubMed / Full text
The incidence of cervical spondylosis decreases with aging in the elderly, and increases with aging in the young and adult population: a hospital-based clinical analysis. / 2016 / PubMed / Full text
Signal intensity loss of the intervertebral discs in the cervical spine of young patients on fluid sensitive sequences. / 03.2016 / PubMed / Full text
The Cervical Spinal Canal Tapers Differently in Patients with Chiari I with and without Syringomyelia. / 04.2016 / PubMed / Full text
Corticospinal tract development and spinal cord innervation differ between cervical and lumbar targets. / 21.01.2015 / PubMed / Full text
Spontaneous age-related cervical disc degeneration in the sand rat. / 06.2014 / PubMed / Full text

CDKN2A

Association between Nrf2 and CDKN2A expression in patients with end-stage renal disease: a pilot study. / 13.07.2020 / PubMed / Full text
Analysis of somatic mutations identifies signs of selection during in vitro aging of primary dermal fibroblasts. / 12.2019 / PubMed / Full text
Analysis of the putative tumor suppressor gene cdkn2ab in pigment cells and melanoma of Xiphophorus and medaka. / 03.2019 / PubMed / Full text
In vitro behavior and UV response of melanocytes derived from carriers of [[CDKN2A]] mutations and MC1R variants. / 03.2019 / PubMed / Full text
Endothelial PPARγ (Peroxisome Proliferator-Activated Receptor-γ) Is Essential for Preventing Endothelial Dysfunction With Aging. / 07.2018 / PubMed / Full text
Upregulation of lactate-inducible snail protein suppresses oncogene-mediated senescence through p16 inactivation. / 26.02.2018 / PubMed / Full text
Cellular aging dynamics after acute malaria infection: A 12-month longitudinal study. / 02.2018 / PubMed / Full text
ARID1A suppresses malignant transformation of human pancreatic cells via mediating senescence-associated miR-503/[[CDKN2A]] regulatory axis. / 18.11.2017 / PubMed / Full text
Cellular Senescence in Mouse Hippocampus After Irradiation and the Role of p53 and p21. / 01.04.2017 / PubMed / Full text
Identification of the activating cytotoxicity receptor NKG2D as a senescence marker in zero-hour kidney biopsies is indicative for clinical outcome. / 06.2017 / PubMed / Full text
ETS Proto-oncogene 1 Transcriptionally Up-regulates the Cholangiocyte Senescence-associated Protein Cyclin-dependent Kinase Inhibitor 2A. / 24.03.2017 / PubMed / Full text
Establishment and application of a novel patient-derived KIAA1549:BRAF-driven pediatric pilocytic astrocytoma model for preclinical drug testing. / 14.02.2017 / PubMed / Full text
Induction of DNA double-strand breaks and cellular senescence by human respiratory syncytial virus. / 18.05.2016 / PubMed / Full text
Targeting genes in insulin-associated signalling pathway, DNA damage, cell proliferation and cell differentiation pathways by tocotrienol-rich fraction in preventing cellular senescence of human diploid fibroblasts. / 11-12.2015 / PubMed / Full text
Alterations of telomere length and DNA methylation in hairdressers: A cross-sectional study. / 03.2016 / PubMed / Full text
Genetics of melanoma progression: the rise and fall of cell senescence. / 03.2016 / PubMed / Full text
Defective autophagy in vascular smooth muscle cells accelerates senescence and promotes neointima formation and atherogenesis. / 02.11.2015 / PubMed / Full text
Genomic regulation of senescence and innate immunity signaling in the retinal pigment epithelium. / 06.2015 / PubMed / Full text
Y-27632, a ROCK inhibitor, delays senescence of putative murine salivary gland stem cells in culture. / 06.2015 / PubMed / Full text
Coordinated control of senescence by lncRNA and a novel T-box3 co-repressor complex. / 29.05.2014 / PubMed / Full text

CXCL1

Contusion spinal cord injury upregulates p53 protein expression in rat soleus muscle at multiple timepoints but not key senescence cytokines. / 02.2020 / PubMed / Full text
Systemic Inflammation and the Increased Risk of Inflamm-Aging and Age-Associated Diseases in People Living With HIV on Long Term Suppressive Antiretroviral Therapy. / 2019 / PubMed / Full text
Inflammatory and Senescent Phenotype of Pancreatic Stellate Cells Induced by Sqstm1 Downregulation Facilitates Pancreatic Cancer Progression. / 2019 / PubMed / Full text
Neuroprotective effects of targeting BET proteins for degradation with dBET1 in aged mice subjected to ischemic stroke. / 07.2019 / PubMed / Full text
Excessive neutrophil levels in the lung underlie the age-associated increase in influenza mortality. / 03.2019 / PubMed / Full text
Prophylactic Palmitoylethanolamide Prolongs Survival and Decreases Detrimental Inflammation in Aged Mice With Bacterial Meningitis. / 2018 / PubMed / Full text
The Role of Pulmonary and Systemic Immunosenescence in Acute Lung Injury. / 08.2018 / PubMed / Full text
Urine Cytokine and Chemokine Levels Predict Urinary Tract Infection Severity Independent of Uropathogen, Urine Bacterial Burden, Host Genetics, and Host Age. / 09.2018 / PubMed / Full text
Aerobic Exercise Protects from Pseudomonas aeruginosa-Induced Pneumonia in Elderly Mice. / 2018 / PubMed / Full text
Infiltrating macrophages contribute to age-related neuroinflammation in C57/BL6 mice. / 07.2018 / PubMed / Full text
Time-Dependent Changes in Local and Serum Levels of Inflammatory Cytokines as Markers for Incised Wound Aging of Skeletal Muscles. / 05.2018 / PubMed / Full text
Age-related decline of the acute local inflammation response: a mitigating role for the adenosine A receptor. / 18.10.2017 / PubMed / Full text
IFN-γ induces senescence-like characteristics in mouse bone marrow mesenchymal stem cells. / 03-04.2017 / PubMed / Full text
Methyl caffeate and some plant constituents inhibit age-related inflammation: effects on senescence-associated secretory phenotype (SASP) formation. / 04.2017 / PubMed / Full text
Adiponectin induces CXCL1 secretion from cancer cells and promotes tumor angiogenesis by inducing stromal fibroblast senescence. / 11.2016 / PubMed / Full text
Senescent peritoneal mesothelium induces a pro-angiogenic phenotype in ovarian cancer cells in vitro and in a mouse xenograft model in vivo. / 01.2016 / PubMed / Full text
CXCL1 Triggers Caspase-3 Dependent Tau Cleavage in Long-Term Neuronal Cultures and in the Hippocampus of Aged Mice: Implications in Alzheimer's Disease. / 2015 / PubMed / Full text
Effects of flavonoids on senescence-associated secretory phenotype formation from bleomycin-induced senescence in BJ fibroblasts. / 15.08.2015 / PubMed / Full text
Microglial Kv1.3 Channels and P2Y12 Receptors Differentially Regulate Cytokine and Chemokine Release from Brain Slices of Young Adult and Aged Mice. / 2015 / PubMed / Full text
Cathelicidin related antimicrobial peptide, laminin, Toll-like receptors and chemokines levels in experimental hypersensitivity pneumonitis in mice. / 06.2015 / PubMed / Full text

CXCR4

Aging-Related Reduced Expression of CXCR4 on Bone Marrow Mesenchymal Stromal Cells Contributes to Hematopoietic Stem and Progenitor Cell Defects. / 08.2020 / PubMed / Full text
Transfer of a human gene variant associated with exceptional longevity improves cardiac function in obese type 2 diabetic mice through induction of the SDF-1/CXCR4 signalling pathway. / 09.2020 / PubMed / Full text
Stromal Cell-Derived Factor 1 Protects Brain Vascular Endothelial Cells from Radiation-Induced Brain Damage. / 10.10.2019 / PubMed / Full text
A Neutrophil Timer Coordinates Immune Defense and Vascular Protection. / 19.02.2019 / PubMed / Full text
Novel molecular mechanisms for the adaptogenic effects of herbal extracts on isolated brain cells using systems biology. / 15.11.2018 / PubMed / Full text
Reducing CXCR4 Resulted in Impairing Proliferation and Promoting Aging. / 2018 / PubMed / Full text
Targeting junctional adhesion molecule-C ameliorates sepsis-induced acute lung injury by decreasing CXCR4 aged neutrophils. / 12.2018 / PubMed / Full text
Tumor microenvironment in functional adrenocortical adenomas: immune cell infiltration in cortisol-producing adrenocortical adenoma. / 07.2018 / PubMed / Full text
Lower resting and exercise-induced circulating angiogenic progenitors and angiogenic T cells in older men. / 01.03.2018 / PubMed / Full text
Adipose-Derived Mesenchymal Stem Cells from the Elderly Exhibit Decreased Migration and Differentiation Abilities with Senescent Properties. / 09.2017 / PubMed / Full text
Conversion of adult endothelium to immunocompetent haematopoietic stem cells. / 25.05.2017 / PubMed / Full text
Chronic Resveratrol Treatment Inhibits MRC5 Fibroblast SASP-Related Protumoral Effects on Melanoma Cells. / 01.09.2017 / PubMed / Full text
The expression of the BPIFB4 and CXCR4 associates with sustained health in long-living individuals from Cilento-Italy. / 22.01.2017 / PubMed / Full text
Age and Human Regenerative Capacity Impact of Cardiovascular Risk Factors. / 16.09.2016 / PubMed / Full text
Effect of age on expression of spermatogonial markers in bovine testis and isolated cells. / 07.2016 / PubMed / Full text
Increased susceptibility of CD4 T cells from elderly individuals to HIV-1 infection and apoptosis is associated with reduced CD4 and enhanced CXCR4 and FAS surface expression levels. / 09.10.2015 / PubMed / Full text
A single fas gene mutation changes lupus onset, severity, location, and molecular abnormalities in mice. / 2015 / PubMed / Full text
Caloric restriction and the adipokine leptin alter the SDF-1 signaling axis in bone marrow and in bone marrow derived mesenchymal stem cells. / 15.07.2015 / PubMed / Full text
CXCR4 blockade induces atherosclerosis by affecting neutrophil function. / 09.2014 / PubMed / Full text
Trafficking phenotype and production of granzyme B by double negative B cells (IgG( )IgD(-)CD27(-)) in the elderly. / 06.2014 / PubMed / Full text

ERG

Effect of age and sex on neurodevelopment and neurodegeneration in the healthy eye: Longitudinal functional and structural study in the Long-Evans rat. / 11.2020 / PubMed / Full text
Mice With a Combined Deficiency of Superoxide Dismutase 1 (Sod1), DJ-1 (Park7), and Parkin (Prkn) Develop Spontaneous Retinal Degeneration With Aging. / 03.09.2019 / PubMed / Full text
Test-retest repeatability of the pattern electroretinogram and flicker electroretinogram. / 12.2019 / PubMed / Full text
Regeneration of Dopaminergic Neurons in Adult Zebrafish Depends on Immune System Activation and Differs for Distinct Populations. / 12.06.2019 / PubMed / Full text
Sirt3 mediates the protective effect of hydrogen in inhibiting ROS-induced retinal senescence. / 01.05.2019 / PubMed / Full text
Further Characterization of the Predominant Inner Retinal Degeneration of Aging Cln3 Knock-In Mice. / 2018 / PubMed / Full text
Two novel forms of ERG oscillation in Drosophila: age and activity dependence. / 03-06.2018 / PubMed / Full text
Loss of XBP1 accelerates age-related decline in retinal function and neurodegeneration. / 04.04.2018 / PubMed / Full text
The Complement System Is Critical in Maintaining Retinal Integrity during Aging. / 2018 / PubMed / Full text
EDI OCT evaluation of choroidal thickness in Stargardt disease. / 2018 / PubMed / Full text
Intensity response function of the photopic negative response (PhNR): effect of age and test-retest reliability. / 08.2017 / PubMed / Full text
Nonamyloidogenic processing of amyloid beta precursor protein is associated with retinal function improvement in aging male APP /PS1ΔE9 mice. / 05.2017 / PubMed / Full text
Absence of DJ-1 causes age-related retinal abnormalities in association with increased oxidative stress. / 03.2017 / PubMed / Full text
Uncoupling neuronal death and dysfunction in Drosophila models of neurodegenerative disease. / 23.06.2016 / PubMed / Full text
Age-related change in fast adaptation mechanisms measured with the scotopic full-field ERG. / 06.2016 / PubMed / Full text
Relation of BAALC and ERG Gene Expression with Overall Survival in Acute Myeloid Leukemia Cases. / 2015 / PubMed / Full text
Differences in Retinal Structure and Function between Aging Male and Female Sprague-Dawley Rats are Strongly Influenced by the Estrus Cycle. / 2015 / PubMed / Full text
Lack of Acid Sphingomyelinase Induces Age-Related Retinal Degeneration. / 2015 / PubMed / Full text
Changes in rod and cone-driven oscillatory potentials in the aging human retina. / 17.07.2014 / PubMed / Full text
The effect of ageing on ocular blood flow, oxygen tension and retinal function during and after intraocular pressure elevation. / 2014 / PubMed / Full text

FES

An outpatient Tai Chi program: Effects on veterans' functional outcomes. / 26.11.2020 / PubMed / Full text
Gait Function in Adults Aged 50 Years and Older With Spina Bifida. / 07.11.2020 / PubMed / Full text
A Single Question as a Screening Tool to Assess Fear of Falling in Young-Old Community-Dwelling Persons. / 09.2020 / PubMed / Full text
Fall-related efficacy is a useful and independent index to detect fall risk in Japanese community-dwelling older people: a 1-year longitudinal study. / 29.10.2019 / PubMed / Full text
Investigating Changes in Real-time Conscious Postural Processing by Older Adults during Different Stance Positions Using Electroencephalography Coherence. / 10-12.2019 / PubMed / Full text
Effectiveness of Daily Use of Bilateral Custom-Made Ankle-Foot Orthoses on Balance, Fear of Falling, and Physical Activity in Older Adults: A Randomized Controlled Trial. / 2019 / PubMed / Full text
Decline in sensorimotor systems explains reduced falls self-efficacy. / 10.2018 / PubMed / Full text
Fear of Falling in Older Adults with Diabetes Mellitus: The IMIAS Study. / 09.2018 / PubMed / Full text
Cross-cultural adaptation and measurement properties testing of the Iconographical Falls Efficacy Scale (Icon-FES). / 07-08.2018 / PubMed / Full text
Binocular Vision Disorders and Visual Attention: Associations With Balance and Mobility in Older Adults. / 01.04.2018 / PubMed / Full text
Genome-wide methylation analysis reveals differentially methylated loci that are associated with an age-dependent increase in bovine fibroblast response to LPS. / 25.05.2017 / PubMed / Full text
FES in Europe and Beyond: Current Translational Research. / 15.09.2016 / PubMed / Full text
Use it or Lose It: Tonic Activity of Slow Motoneurons Promotes Their Survival and Preferentially Increases Slow Fiber-Type Groupings in Muscles of Old Lifelong Recreational Sportsmen. / 15.09.2016 / PubMed / Full text
Recovery from muscle weakness by exercise and FES: lessons from Masters, active or sedentary seniors and SCI patients. / 08.2017 / PubMed / Full text
Biology of Muscle Atrophy and of its Recovery by FES in Aging and Mobility Impairments: Roots and By-Products. / 24.08.2015 / PubMed / Full text
Balance Disorders in the Elderly: Does Instability Increase Over Time? / 07.2016 / PubMed / Full text
Age group classification and gender detection based on forced expiratory spirometry. / 08.2015 / PubMed / Full text
Is there a relationship between short FES-I test scores and objective assessment of balance in the older people with age-induced instability? / 01-02.2016 / PubMed / Full text
Age-associated declines in muscle mass, strength, power, and physical performance: impact on fear of falling and quality of life. / 02.2016 / PubMed / Full text
Effects of functional electric stimulation cycle ergometry training on lower limb musculature in acute sci individuals. / 01.09.2005 / PubMed / Full text

JAK2

Senescence in Monocytes Facilitates Dengue Virus Infection by Increasing Infectivity. / 2020 / PubMed / Full text
Quercetin Directly Targets JAK2 and PKCδ and Prevents UV-Induced Photoaging in Human Skin. / 23.10.2019 / PubMed / Full text
[Red blood cell lifespan detected by endogenous carbon monoxide breath test in patients with polycythemia vera]. / 01.10.2019 / PubMed / Full text
Roles of JAK2 in Aging, Inflammation, Hematopoiesis and Malignant Transformation. / 08.08.2019 / PubMed / Full text
The mir-465 family is upregulated with age and attenuates growth hormone signaling in mouse liver. / 04.2019 / PubMed / Full text
Clonal hematopoiesis: Genes and underlying mechanisms in cardiovascular disease development. / 06.2019 / PubMed / Full text
Distinctive features of polycythaemia vera in New Zealand Polynesians. / 21.09.2018 / PubMed
Immunologic effects of chronic administration of tofacitinib, a Janus kinase inhibitor, in cynomolgus monkeys and rats - Comparison of juvenile and adult responses. / 04.2018 / PubMed / Full text
Molecular Pathogenesis of Myeloproliferative Neoplasms: Influence of Age and Gender. / 10.2017 / PubMed / Full text
Proliferation Drives Aging-Related Functional Decline in a Subpopulation of the Hematopoietic Stem Cell Compartment. / 23.05.2017 / PubMed / Full text
The Dyslexia-susceptibility Protein KIAA0319 Inhibits Axon Growth Through Smad2 Signaling. / 01.03.2017 / PubMed / Full text
JAK-STAT signaling mediates the senescence of bone marrow-mesenchymal stem cells from systemic lupus erythematosus patients. / 01.03.2017 / PubMed / Full text
Oxidative stress induces the decline of brain EPO expression in aging rats. / 10.2016 / PubMed / Full text
Scribble is required for pregnancy-induced alveologenesis in the adult mammary gland. / 15.06.2016 / PubMed / Full text
Type I collagen aging impairs discoidin domain receptor 2-mediated tumor cell growth suppression. / 03.05.2016 / PubMed / Full text
Exogenous H2S contributes to recovery of ischemic post-conditioning-induced cardioprotection by decrease of ROS level via down-regulation of NF-κB and JAK2-STAT3 pathways in the aging cardiomyocytes. / 2016 / PubMed / Full text
Correlation Analysis Between Expression Levels of Hepatic Growth Hormone Receptor, Janus Kinase 2, Insulin-Like Growth Factor-I Genes and Dwarfism Phenotype in Bama Minipig. / 02.2015 / PubMed / Full text
Emerging drugs for the treatment of myelofibrosis. / 2015 / PubMed / Full text
PLA2R1: expression and function in cancer. / 08.2014 / PubMed / Full text
Adipocyte-specific deficiency of Janus kinase (JAK) 2 in mice impairs lipolysis and increases body weight, and leads to insulin resistance with ageing. / 05.2014 / PubMed / Full text

MMP9

EGR1 promotes the cartilage degeneration and hypertrophy by activating the Krüppel-like factor 5 and β-catenin signaling. / 01.09.2019 / PubMed / Full text
[Effect of saponins extracted from Panax japonicas on inhibiting myocardial fibrosis by TGF-β1/Smad3 signaling pathway in aging rats]. / 11.2018 / PubMed / Full text
Retinoic acid promotes in vitro follicle activation in the cat ovary by regulating expression of matrix metalloproteinase 9. / 2018 / PubMed / Full text
Oxidative stress induces p38MAPK-dependent senescence in the feto-maternal interface cells. / 07.2018 / PubMed / Full text
Activation of DNA demethylases attenuates aging-associated arterial stiffening and hypertension. / 08.2018 / PubMed / Full text
Fibronectin Containing Extra Domain A Induces Plaque Destabilization in the Innominate Artery of Aged Apolipoprotein E-Deficient Mice. / 03.2018 / PubMed / Full text
Timing and duration of nursing from birth affect neonatal porcine uterine matrix metalloproteinase 9 and tissue inhibitor of metalloproteinase 1. / 04.2017 / PubMed / Full text
Secondhand Smoke Exposure Enhances Cardiac Fibrosis Effects on the Aging Rat Hearts. / 09.2016 / PubMed / Full text
Transcriptome Analysis of B Cell Immune Functions in Periodontitis: Mucosal Tissue Responses to the Oral Microbiome in Aging. / 2016 / PubMed / Full text
Sperm-associated antigen 9 (SPAG9) promotes the survival and tumor growth of triple-negative breast cancer cells. / 10.2016 / PubMed / Full text
Differential Matrix Metalloprotease (MMP) Expression Profiles Found in Aged Gingiva. / 2016 / PubMed / Full text
Inflammageing assessed by MMP9 in normal Japanese individuals and the patients with Werner syndrome. / 05.2016 / PubMed / Full text
Bone biology-related gingival transcriptome in ageing and periodontitis in non-human primates. / 05.2016 / PubMed / Full text
The Nox1/4 Dual Inhibitor GKT137831 or Nox4 Knockdown Inhibits Angiotensin-II-Induced Adult Mouse Cardiac Fibroblast Proliferation and Migration. AT1 Physically Associates With Nox4. / 05.2016 / PubMed / Full text
Defective autophagy in vascular smooth muscle cells accelerates senescence and promotes neointima formation and atherogenesis. / 02.11.2015 / PubMed / Full text
Correlations between Photodegradation of Bisretinoid Constituents of Retina and Dicarbonyl Adduct Deposition. / 06.11.2015 / PubMed / Full text
Fat and Sucrose Intake Induces Obesity-Related Bone Metabolism Disturbances: Kinetic and Reversibility Studies in Growing and Adult Rats. / 01.2016 / PubMed / Full text
Endothelin-1 critically influences cardiac function via superoxide-MMP9 cascade. / 21.04.2015 / PubMed / Full text
[The expression of differential and matrix remodelling factors in human buccal epithelium in aging]. / 2013 / PubMed
A transcriptional roadmap to the senescence and differentiation of human oral keratinocytes. / 01.2015 / PubMed / Full text

TFEB

A Novel Lipofuscin-detecting Marker of Senescence Relates With Hypoxia, Dysregulated Autophagy and With Poor Prognosis in Non-small-cell-lung Cancer. / 11-12.2020 / PubMed / Full text
ESC-sEVs Rejuvenate Senescent Hippocampal NSCs by Activating Lysosomes to Improve Cognitive Dysfunction in Vascular Dementia. / 05.2020 / PubMed / Full text
Nitrative Stress-Related Autophagic Insufficiency Participates in Hyperhomocysteinemia-Induced Renal Aging. / 2020 / PubMed / Full text
Polyamines reverse immune senescence via the translational control of autophagy. / 01.2020 / PubMed / Full text
Polyamines Control eIF5A Hypusination, TFEB Translation, and Autophagy to Reverse B Cell Senescence. / 03.10.2019 / PubMed / Full text
Insulin-like peptides and the mTOR-TFEB pathway protect [i]Caenorhabditis elegans[/i] hermaphrodites from mating-induced death. / 08.07.2019 / PubMed / Full text
Double knockout of Akt2 and AMPK predisposes cardiac aging without affecting lifespan: Role of autophagy and mitophagy. / 01.07.2019 / PubMed / Full text
TFEB protects nucleus pulposus cells against apoptosis and senescence via restoring autophagic flux. / 02.2019 / PubMed / Full text
Autophagy and mitophagy flux in young and aged skeletal muscle following chronic contractile activity. / 08.2018 / PubMed / Full text
Nuclear Export Inhibition Enhances HLH-30/TFEB Activity, Autophagy, and Lifespan. / 15.05.2018 / PubMed / Full text
Trans-Fats Inhibit Autophagy Induced by Saturated Fatty Acids. / 04.2018 / PubMed / Full text
Small-molecule TFEB pathway agonists that ameliorate metabolic syndrome in mice and extend C. elegans lifespan. / 22.12.2017 / PubMed / Full text
Peroxisomes contribute to oxidative stress in neurons during doxorubicin-based chemotherapy. / 01.2018 / PubMed / Full text
TOR-mediated regulation of metabolism in aging. / 12.2017 / PubMed / Full text
Nuclear AMPK regulated CARM1 stabilization impacts autophagy in aged heart. / 29.04.2017 / PubMed / Full text
TFEB ameliorates the impairment of the autophagy-lysosome pathway in neurons induced by doxorubicin. / 16.12.2016 / PubMed / Full text
Role of TFEB Mediated Autophagy, Oxidative Stress, Inflammation, and Cell Death in Endotoxin Induced Myocardial Toxicity of Young and Aged Mice. / 2016 / PubMed / Full text
Critical role of lysosomes in the dysfunction of human Cardiac Stem Cells obtained from failing hearts. / 01.08.2016 / PubMed / Full text
Mondo complexes regulate TFEB via TOR inhibition to promote longevity in response to gonadal signals. / 22.03.2016 / PubMed / Full text
Transcriptional and epigenetic regulation of autophagy in aging. / 2015 / PubMed / Full text

ACE2

How Does SARS-CoV-2 Affect the Central Nervous System? A Working Hypothesis. / 2020 / PubMed / Full text
Bioinformatic characterization of angiotensin-converting enzyme 2, the entry receptor for SARS-CoV-2. / 2020 / PubMed / Full text
A mouse-adapted model of SARS-CoV-2 to test COVID-19 countermeasures. / 10.2020 / PubMed / Full text
COVID-19 and Senotherapeutics: Any Role for the Naturally-occurring Dipeptide Carnosine? / 07.2020 / PubMed / Full text
The dual impact of ACE2 in COVID-19 and ironical actions in geriatrics and pediatrics with possible therapeutic solutions. / 15.09.2020 / PubMed / Full text
The possible pathophysiology mechanism of cytokine storm in elderly adults with COVID-19 infection: the contribution of "inflame-aging". / 09.2020 / PubMed / Full text
Decoding SARS-CoV-2 hijacking of host mitochondria in COVID-19 pathogenesis. / 01.08.2020 / PubMed / Full text
A Mouse Model of SARS-CoV-2 Infection and Pathogenesis. / 08.07.2020 / PubMed / Full text
COVID-19-associated cardiovascular morbidity in older adults: a position paper from the Italian Society of Cardiovascular Researches. / 08.2020 / PubMed / Full text
Gut microbiota and Covid-19- possible link and implications. / 08.2020 / PubMed / Full text
Inflamm-aging: Why older men are the most susceptible to SARS-CoV-2 complicated outcomes. / 06.2020 / PubMed / Full text
Restoration of the Renin-Angiotensin System Balance Is a Part of the Effect of Fasting on Cardiovascular Rejuvenation: Role of Age and Fasting Models. / 08.2020 / PubMed / Full text
Angiotensin 1-7 alleviates aging-associated muscle weakness and bone loss, but is not associated with accelerated aging in ACE2-knockout mice. / 30.09.2019 / PubMed / Full text
Age-dependent differences in pulmonary host responses in ARDS: a prospective observational cohort study. / 14.05.2019 / PubMed / Full text
The protective effect of resveratrol on vascular aging by modulation of the renin-angiotensin system. / 03.2018 / PubMed / Full text
Sex differences in the aging pattern of renin-angiotensin system serum peptidases. / 2017 / PubMed / Full text
Chymase-dependent production of angiotensin II: an old enzyme in old hearts. / 01.02.2017 / PubMed / Full text
Age-Associated Changes in the Vascular Renin-Angiotensin System in Mice. / 2016 / PubMed / Full text
Angiotensin converting enzyme 2/Ang-(1-7)/mas axis protects brain from ischemic injury with a tendency of age-dependence. / 05.2014 / PubMed / Full text

CFI

Psychosocial Resources for Hedonic Balance, Life Satisfaction and Happiness in the Elderly: A Path Analysis. / 06.08.2020 / PubMed / Full text
Validity and Reliability of the Flourishing Scale in a Sample of Older Adults in Iran. / 2020 / PubMed / Full text
The decision about retirement: A scale to describe representations and practices of medical doctors and nurses. / 07-08.2016 / PubMed / Full text
Family versus intimate partners: Estimating who matters more for health in a 20-year longitudinal study. / 03.2020 / PubMed / Full text
Adapting and validating the Rosenberg Self-Esteem Scale for elderly Spanish population. / 02.2020 / PubMed / Full text
Mediating Role of Fall-related Efficacy in a Fall Prevention Program. / 01.03.2019 / PubMed / Full text
An application of Bayesian measurement invariance to modelling cognition over time in the English Longitudinal Study of Ageing. / 12.2018 / PubMed / Full text
[New semantic-cultural validation and psychometric study of the CASP-19 scale in adult and elderly Brazilians]. / 11.10.2018 / PubMed / Full text
Mental status evaluation in older adults with cancer: Development of the Mental Health Index-13. / 03.2019 / PubMed / Full text
The ACTIVE conceptual framework as a structural equation model. / 01-02.2018 / PubMed / Full text
The Utility of the Cognitive Function Instrument (CFI) to Detect Cognitive Decline in Non-Demented Older Adults. / 2017 / PubMed / Full text
The effect of age on the response of retinal capillary filling to changes in intraocular pressure measured by optical coherence tomography angiography. / 01.2018 / PubMed / Full text
Health, coping and subjective well-being: results of a longitudinal study of elderly Israelis. / 06.2017 / PubMed / Full text
Women's intentions to use fertility preservation to prevent age-related fertility decline. / 01.2016 / PubMed / Full text
Factorial Structure and Measurement Invariance of the PANAS in Spanish Older Adults. / 03.03.2015 / PubMed / Full text
Assessing the factor structure of well-being in older adults: findings from the National Health and Aging Trends Study. / 08.2016 / PubMed / Full text
Measuring frailty using self-report and test-based health measures. / 05.2015 / PubMed / Full text
CASP-19 special section: how does chronic disease status affect CASP quality of life at older ages? Examining the WHO ICF disability domains as mediators of this relationship. / 07.2015 / PubMed / Full text
Differential trajectories of well-being in older adult women: the role of optimism. / 11.2014 / PubMed / Full text

CLU

Expression of Clusterin suppresses Cr(VI)-induced premature senescence through activation of PI3K/AKT pathway. / 15.11.2019 / PubMed / Full text
Informative combination of CLU rs11136000, serum HDL levels, diabetes, and age as a new piece of puzzle-picture of predictive medicine for cognitive disorders. / 02.2019 / PubMed / Full text
Integrative transcriptome analyses of the aging brain implicate altered splicing in Alzheimer's disease susceptibility. / 11.2018 / PubMed / Full text
DNA methylation analysis on purified neurons and glia dissects age and Alzheimer's disease-specific changes in the human cortex. / 25.07.2018 / PubMed / Full text
Recent studies on cellular and molecular mechanisms in Alzheimer's disease: focus on epigenetic factors and histone deacetylase. / 28.03.2018 / PubMed / Full text
Role of CLU, PICALM, and TNK1 Genotypes in Aging With and Without Alzheimer's Disease. / 05.2018 / PubMed / Full text
Late Onset Alzheimer's Disease Risk Variants in Cognitive Decline: The PATH Through Life Study. / 2017 / PubMed / Full text
Association and interaction effects of Alzheimer's disease-associated genes and lifestyle on cognitive aging in older adults in a Taiwanese population. / 11.04.2017 / PubMed / Full text
An Alzheimer's Disease Genetic Risk Score Predicts Longitudinal Thinning of Hippocampal Complex Subregions in Healthy Older Adults. / 05-06.2016 / PubMed / Full text
Genetically-mediated Grey and White Matter Alteration in Normal Elderly Individuals with the CLU-C Allele Gene. / 2016 / PubMed / Full text
Hippocampal proteomics defines pathways associated with memory decline and resilience in normal aging and Alzheimer's disease mouse models. / 30.03.2017 / PubMed / Full text
Risk-reducing Apolipoprotein E and Clusterin genotypes protect against the consequences of poor vascular health on executive function performance and change in nondemented older adults. / 06.2016 / PubMed / Full text
Impact of PICALM and CLU on hippocampal degeneration. / 07.2016 / PubMed / Full text
Gene-based aggregate SNP associations between candidate AD genes and cognitive decline. / 04.2016 / PubMed / Full text
Apolipoprotein E and Clusterin can magnify effects of personality vulnerability on declarative memory performance in non-demented older adults. / 05.2016 / PubMed / Full text
Mesterolone treatment of aging male syndrome improves lower urinary tract symptoms. / 12.2014 / PubMed
Combined effects of Alzheimer risk variants in the CLU and ApoE genes on ventricular expansion patterns in the elderly. / 07.05.2014 / PubMed / Full text
The benefits of staying active in old age: physical activity counteracts the negative influence of PICALM, BIN1, and CLU risk alleles on episodic memory functioning. / 06.2014 / PubMed / Full text
Age-dependent effect of Alzheimer's risk variant of CLU on EEG alpha rhythm in non-demented adults. / 2013 / PubMed / Full text

GDF15

Disease-specific plasma levels of mitokines FGF21, GDF15, and Humanin in type II diabetes and Alzheimer's disease in comparison with healthy aging. / 31.10.2020 / PubMed / Full text
Growth differentiation factor 15 protects against the aging-mediated systemic inflammatory response in humans and mice. / 08.2020 / PubMed / Full text
Analysis of Epigenetic Age Predictors in Pain-Related Conditions. / 2020 / PubMed / Full text
GDF15 Plasma Level Is Inversely Associated With Level of Physical Activity and Correlates With Markers of Inflammation and Muscle Weakness. / 2020 / PubMed / Full text
GDF15 is an epithelial-derived biomarker of idiopathic pulmonary fibrosis. / 01.10.2019 / PubMed / Full text
Senescence-associated tissue microenvironment promotes colon cancer formation through the secretory factor GDF15. / 12.2019 / PubMed / Full text
mTORC1 underlies age-related muscle fiber damage and loss by inducing oxidative stress and catabolism. / 06.2019 / PubMed / Full text
Expression of lipogenic markers is decreased in subcutaneous adipose tissue and adipocytes of older women and is negatively linked to GDF15 expression. / 08.2019 / PubMed / Full text
Growth differentiation factor 15 (GDF15): A survival protein with therapeutic potential in metabolic diseases. / 06.2019 / PubMed / Full text
[The role of «Youth and aging proteins» in essential hypertension pathogenesis.] / 2018 / PubMed
A framework for selection of blood-based biomarkers for geroscience-guided clinical trials: report from the TAME Biomarkers Workgroup. / 12.2018 / PubMed / Full text
Towards frailty biomarkers: Candidates from genes and pathways regulated in aging and age-related diseases. / 11.2018 / PubMed / Full text
Plasma proteomic signature of age in healthy humans. / 10.2018 / PubMed / Full text
Human Aging and Longevity Are Characterized by High Levels of Mitokines. / 23.04.2019 / PubMed / Full text
Induction of Growth Differentiation Factor 15 in Skeletal Muscle of Old Taurine Transporter Knockout Mouse. / 2018 / PubMed / Full text
Cigarette Smoke Induces Human Airway Epithelial Senescence via Growth Differentiation Factor 15 Production. / 09.2016 / PubMed / Full text
Secreted growth differentiation factor 15 as a potential biomarker for mitochondrial dysfunctions in aging and age-related disorders. / 03.2016 / PubMed / Full text
GDF15 contributes to radiation-induced senescence through the ROS-mediated p16 pathway in human endothelial cells. / 01.03.2016 / PubMed / Full text
hNAG-1 increases lifespan by regulating energy metabolism and insulin/IGF-1/mTOR signaling. / 08.2014 / PubMed / Full text

MCC

Multiple chronic conditions and risk of cognitive impairment and dementia among older Americans: findings from the Aging, Demographics, and Memory Study (ADAMS). / 07.07.2020 / PubMed / Full text
Behaviour consistency is a sensitive tool for distinguishing the effects of aging on physical activity. / 01.07.2020 / PubMed / Full text
Burden on Caregivers of Adults with Multiple Chronic Conditions: Intersectionality of Age, Gender, Education level, Employment Status, and Impact on Social Life. / 09.2020 / PubMed / Full text
Using the Technology Acceptance Model to Explore User Experience, Intent to Use, and Use Behavior of a Patient Portal Among Older Adults With Multiple Chronic Conditions: Descriptive Qualitative Study. / 08.04.2019 / PubMed / Full text
Trends in Risk of Limitations in Instrumental Activities of Daily Living Over Age in Older Persons With and Without Multiple Chronic Conditions. / 01.01.2020 / PubMed / Full text
Association between treatment of superficial bladder cancer and 10-year mortality in older adults with multiple chronic conditions. / 01.12.2018 / PubMed / Full text
The AGING Initiative experience: a call for sustained support for team science networks. / 18.05.2018 / PubMed / Full text
Evidence on selection, optimization, and compensation strategies to optimize aging with multiple chronic conditions: A literature review. / 09-10.2018 / PubMed / Full text
Chronic disease burden predicts food insecurity among older adults. / 06.2018 / PubMed / Full text
Differences Between Younger and Older US Adults With Multiple Chronic Conditions. / 07.09.2017 / PubMed / Full text
Prevalence, Correlates, and Time Trends of Multiple Chronic Conditions Among Israeli Adults: Estimates From the Israeli National Health Interview Survey, 2014-2015. / 10.08.2017 / PubMed / Full text
Seed incorporation during vinification and its impact on chemical and organoleptic properties in Syzygium cumini wine. / 15.12.2017 / PubMed / Full text
Research Priorities to Advance the Health and Health Care of Older Adults with Multiple Chronic Conditions. / 07.2017 / PubMed / Full text
The ACHRU-CPP versus usual care for older adults with type-2 diabetes and multiple chronic conditions and their family caregivers: study protocol for a randomized controlled trial. / 06.02.2017 / PubMed / Full text
Changes in Depressive Symptoms among Older Adults with Multiple Chronic Conditions: Role of Positive and Negative Social Support. / 26.12.2016 / PubMed / Full text
Sex-specific effects of cytotoxic chemotherapy agents cyclophosphamide and mitomycin C on gene expression, oxidative DNA damage, and epigenetic alterations in the prefrontal cortex and hippocampus - an aging connection. / 04.2016 / PubMed / Full text
Reduced mucociliary clearance in old mice is associated with a decrease in Muc5b mucin. / 01.05.2016 / PubMed / Full text
Corrupt practices negatively influenced food security and live expectancy in developing countries. / 2015 / PubMed / Full text
Decision-making and cancer screening: a qualitative study of older adults with multiple chronic conditions. / 03.2015 / PubMed / Full text

MMP2

Cellular retinoic acid binding protein-II expression and its potential role in skin aging. / 18.03.2019 / PubMed / Full text
[Effect of saponins extracted from Panax japonicas on inhibiting myocardial fibrosis by TGF-β1/Smad3 signaling pathway in aging rats]. / 11.2018 / PubMed / Full text
TMT-Based Quantitative Proteomic Analysis Reveals Proteomic Changes Involved in Longevity. / 07.2019 / PubMed / Full text
MicroRNA-338-5p plays a tumor suppressor role in glioma through inhibition of the MAPK-signaling pathway by binding to FOXD1. / 12.2018 / PubMed / Full text
PM2.5 promotes abdominal aortic aneurysm formation in angiotensin Ⅱ-infused apoe-/- mice. / 08.2018 / PubMed / Full text
Activation of DNA demethylases attenuates aging-associated arterial stiffening and hypertension. / 08.2018 / PubMed / Full text
MMP2-A2M interaction increases ECM accumulation in aged rat kidney and its modulation by calorie restriction. / 19.01.2018 / PubMed / Full text
Systemic analysis of gene expression profiles in porcine granulosa cells during aging. / 14.11.2017 / PubMed / Full text
Timing and duration of nursing from birth affect neonatal porcine uterine matrix metalloproteinase 9 and tissue inhibitor of metalloproteinase 1. / 04.2017 / PubMed / Full text
Secondhand Smoke Exposure Enhances Cardiac Fibrosis Effects on the Aging Rat Hearts. / 09.2016 / PubMed / Full text
Sperm-associated antigen 9 (SPAG9) promotes the survival and tumor growth of triple-negative breast cancer cells. / 10.2016 / PubMed / Full text
Stimulation of cellular senescent processes, including secretory phenotypes and anti-oxidant responses, after androgen deprivation therapy in human prostate cancer. / 01.2017 / PubMed / Full text
Unbiased analysis of senescence associated secretory phenotype (SASP) to identify common components following different genotoxic stresses. / 07.2016 / PubMed / Full text
Synaptic roles for phosphomannomutase type 2 in a new Drosophila congenital disorder of glycosylation disease model. / 01.05.2016 / PubMed / Full text
Correlations between Photodegradation of Bisretinoid Constituents of Retina and Dicarbonyl Adduct Deposition. / 06.11.2015 / PubMed / Full text
Fat and Sucrose Intake Induces Obesity-Related Bone Metabolism Disturbances: Kinetic and Reversibility Studies in Growing and Adult Rats. / 01.2016 / PubMed / Full text
Differential levels of cathepsin B and L in serum between young and aged healthy people and their association with matrix metalloproteinase 2. / 09-10.2015 / PubMed / Full text
[The expression of differential and matrix remodelling factors in human buccal epithelium in aging]. / 2013 / PubMed
Metzincins and related genes in experimental renal ageing: towards a unifying fibrosis classifier across species. / 06.2014 / PubMed / Full text

NAMPT

Over-expression of Nicotinamide phosphoribosyltransferase in mouse cells confers protective effect against oxidative and ER stress-induced premature senescence. / 08.2020 / PubMed / Full text
Resistance training increases muscle NAD and NADH concentrations as well as NAMPT protein levels and global sirtuin activity in middle-aged, overweight, untrained individuals. / 05.05.2020 / PubMed / Full text
Differential Expression of Human N-Alpha-Acetyltransferase 40 (hNAA40), Nicotinamide Phosphoribosyltransferase (NAMPT) and Sirtuin-1 (SIRT-1) Pathway in Obesity and T2DM: Modulation by Metformin and Macronutrient Intake. / 2019 / PubMed / Full text
Aerobic and resistance exercise training reverses age-dependent decline in NAD salvage capacity in human skeletal muscle. / 07.2019 / PubMed / Full text
Extracellular Vesicle-Contained eNAMPT Delays Aging and Extends Lifespan in Mice. / 06.08.2019 / PubMed / Full text
lncRNA GAS5/miR-223/NAMPT axis modulates the cell proliferation and senescence of endothelial progenitor cells through PI3K/AKT signaling. / 09.2019 / PubMed / Full text
Aged Nicotinamide Riboside Kinase 2 Deficient Mice Present an Altered Response to Endurance Exercise Training. / 2018 / PubMed / Full text
Loss of NAMPT in aging retinal pigment epithelium reduces NAD availability and promotes cellular senescence. / 12.06.2018 / PubMed / Full text
Nicotinamide phosphoribosyltransferase delays cellular senescence by upregulating SIRT1 activity and antioxidant gene expression in mouse cells. / 12.2017 / PubMed / Full text
Deletion of Nampt in Projection Neurons of Adult Mice Leads to Motor Dysfunction, Neurodegeneration, and Death. / 29.08.2017 / PubMed / Full text
Nicotinamide Phosphoribosyltransferase in Smooth Muscle Cells Maintains Genome Integrity, Resists Aortic Medial Degeneration, and Is Suppressed in Human Thoracic Aortic Aneurysm Disease. / 09.06.2017 / PubMed / Full text
Effect of lifelong football training on the expression of muscle molecular markers involved in healthy longevity. / 04.2017 / PubMed / Full text
Aging and caloric restriction impact adipose tissue, adiponectin, and circulating lipids. / 06.2017 / PubMed / Full text
Autophagic homeostasis is required for the pluripotency of cancer stem cells. / 02.2017 / PubMed / Full text
NAMPT regulates senescence, proliferation, and migration of endothelial progenitor cells through the SIRT1 AS lncRNA/miR-22/SIRT1 pathway. / 23.09.2016 / PubMed / Full text
Hepatic NAD( ) deficiency as a therapeutic target for non-alcoholic fatty liver disease in ageing. / 08.2016 / PubMed / Full text
Targeting Nicotinamide Phosphoribosyltransferase as a Potential Therapeutic Strategy to Restore Adult Neurogenesis. / 06.2016 / PubMed / Full text
A critical role of nicotinamide phosphoribosyltransferase in human telomerase reverse transcriptase induction by resveratrol in aortic smooth muscle cells. / 10.05.2015 / PubMed / Full text
Relative importance of redox buffers GSH and NAD(P)H in age-related neurodegeneration and Alzheimer disease-like mouse neurons. / 08.2014 / PubMed / Full text

SST

The distance to death perceptions of older adults explain why they age in place: A theoretical examination. / 09.2020 / PubMed / Full text
Population Segmentation Based on Healthcare Needs: Validation of a Brief Clinician-Administered Tool. / 30.06.2020 / PubMed / Full text
Examination on how emotion regulation mediates the relationship between future time perspective and well-being: a counter-evidence to the socioemotional selectivity theory. / 03.2020 / PubMed / Full text
Shear-Wave and Strain Ultrasound Elastography of the Supraspinatus and Infraspinatus Tendons in Patients with Idiopathic Adhesive Capsulitis of the Shoulder: A Prospective Case-Control Study. / 07.2019 / PubMed / Full text
Counting down while time flies: implications of age-related time acceleration for goal pursuit across adulthood. / 04.2019 / PubMed / Full text
Relative costs and benefits of alternative reproductive phenotypes at different temperatures - genotype-by-environment interactions in a sexually selected trait. / 11.07.2018 / PubMed / Full text
Climate change and functional traits affect population dynamics of a long-lived seabird. / 07.2018 / PubMed / Full text
Influence of season, age and management on scrotal thermal profile in Murrah bulls using scrotal infrared digital thermography. / 12.2017 / PubMed / Full text
The roles of chronological age and time perspective in memory positivity. / 07.2018 / PubMed / Full text
Atypical Red Blood Cells Are Prevalent in California Sea Lion Pups Born during Anomalous Sea Surface Temperature Events. / 09-10.2017 / PubMed / Full text
DNA methylation-based age prediction from saliva: High age predictability by combination of 7 CpG markers. / 07.2017 / PubMed / Full text
Sleep/wake movement velocities, trajectories and micro-arousals during maturation in rats. / 07.02.2017 / PubMed / Full text
When meaning matters more: Media preferences across the adult life span. / 08.2016 / PubMed / Full text
An improved spatial span test of visuospatial memory. / 09.2016 / PubMed / Full text
Hypermethylation of BDNF and SST Genes in the Orbital Frontal Cortex of Older Individuals: A Putative Mechanism for Declining Gene Expression with Age. / 10.2015 / PubMed / Full text
Sleep/Wake Dynamics Changes during Maturation in Rats. / 2015 / PubMed / Full text
Sleep disturbance associated with rotator cuff tear: correction with arthroscopic rotator cuff repair. / 06.2015 / PubMed / Full text
A cortical disinhibitory circuit for enhancing adult plasticity. / 27.01.2015 / PubMed / Full text
Telemetry and random-walk models reveal complex patterns of partial migration in a large marine predator. / 11.2013 / PubMed / Full text

UCP1

Muscle-dependent regulation of adipose tissue function in long-lived growth hormone-mutant mice. / 28.05.2020 / PubMed / Full text
Lack of UCP1 stimulates fatty liver but mediates UCP1-independent action of beige fat to improve hyperlipidemia in Apoe knockout mice. / 01.07.2020 / PubMed / Full text
Postnatal leptin surge is critical for the transient induction of the developmental beige adipocytes in mice. / 01.04.2020 / PubMed / Full text
Age-related sex differences in the expression of important disease-linked mitochondrial proteins in mice. / 05.12.2019 / PubMed / Full text
An anti-inflammatory phenotype in visceral adipose tissue of old lean mice, augmented by exercise. / 19.08.2019 / PubMed / Full text
Brown and Beige Adipose Tissue and Aging. / 2019 / PubMed / Full text
Resveratrol and HIV-protease inhibitors control UCP1 expression through opposite effects on p38 MAPK phosphorylation in human adipocytes. / 02.2020 / PubMed / Full text
Circulating factors present in the sera of naturally skinny people may influence cell commitment and adipocyte differentiation of mesenchymal stromal cells. / 26.03.2019 / PubMed / Full text
Assessment of the Aging of the Brown Adipose Tissue by F-FDG PET/CT Imaging in the Progeria Mouse Model Lmna . / 2018 / PubMed / Full text
Inactivation of the E3 Ubiquitin Ligase IDOL Attenuates Diet-Induced Obesity and Metabolic Dysfunction in Mice. / 08.2018 / PubMed / Full text
Rapamycin Reverses Metabolic Deficits in Lamin A/C-Deficient Mice. / 06.12.2016 / PubMed / Full text
Targeted mitochondrial uncoupling beyond UCP1 - The fine line between death and metabolic health. / 03.2017 / PubMed / Full text
Methionine restriction improves renal insulin signalling in aged kidneys. / 07.2016 / PubMed / Full text
Age-related changes of serum mitochondrial uncoupling 1, rumen and rectal temperature in goats. / 07.2016 / PubMed / Full text
Sestrin2, a Regulator of Thermogenesis and Mitohormesis in Brown Adipose Tissue. / 2015 / PubMed / Full text
[The role of uncoupling proteins in mechanisms of protection from oxidative stress]. / 2015 / PubMed / Full text
Miglitol protects against age-dependent weight gain in mice: A potential role of increased UCP1 content in brown adipose tissue. / 2015 / PubMed / Full text
Shc depletion stimulates brown fat activity in vivo and in vitro. / 12.2014 / PubMed / Full text
Inducible brown adipocytes in subcutaneous inguinal white fat: the role of continuous sympathetic stimulation. / 01.11.2014 / PubMed / Full text

CDKN1A

Involvement of CDKN1A (p21) in cellular senescence in response to heat and irradiation stress during preimplantation development. / 05.2020 / PubMed / Full text
Chromatin remodeling factor BAZ1A regulates cellular senescence in both cancer and normal cells. / 15.07.2019 / PubMed / Full text
Histone demethylase KDM6B regulates 1,25-dihydroxyvitamin D3-induced senescence in glioma cells. / 08.2019 / PubMed / Full text
A Novel [i]Dnmt3a1[/i] Transcript Inhibits Adipogenesis. / 2018 / PubMed / Full text
Altered modulation of lamin A/C-HDAC2 interaction and p21 expression during oxidative stress response in HGPS. / 10.2018 / PubMed / Full text
Conditioned medium from stimulated macrophages inhibits growth but induces an inflammatory phenotype in breast cancer cells. / 10.2018 / PubMed / Full text
DNA damage and neurodegenerative phenotypes in aged Ciz1 null mice. / 02.2018 / PubMed / Full text
Cellular Senescence in Mouse Hippocampus After Irradiation and the Role of p53 and p21. / 01.04.2017 / PubMed / Full text
p16 enhances the transcriptional and the apoptotic functions of p53 through DNA-dependent interaction. / 07.2017 / PubMed / Full text
Establishment and application of a novel patient-derived KIAA1549:BRAF-driven pediatric pilocytic astrocytoma model for preclinical drug testing. / 14.02.2017 / PubMed / Full text
Phosphorylation of MITF by AKT affects its downstream targets and causes TP53-dependent cell senescence. / 11.2016 / PubMed / Full text
Induction of DNA double-strand breaks and cellular senescence by human respiratory syncytial virus. / 18.05.2016 / PubMed / Full text
Docosahexaenoic acid prevented tumor necrosis factor alpha-induced endothelial dysfunction and senescence. / 01.2016 / PubMed / Full text
TP53inp1 Gene Is Implicated in Early Radiation Response in Human Fibroblast Cells. / 23.10.2015 / PubMed / Full text
Genomic regulation of senescence and innate immunity signaling in the retinal pigment epithelium. / 06.2015 / PubMed / Full text
Tocotrienol-rich fraction prevents cellular aging by modulating cell proliferation signaling pathways. / 2015 / PubMed / Full text
Orphan nuclear receptor TLX functions as a potent suppressor of oncogene-induced senescence in prostate cancer via its transcriptional co-regulation of the CDKN1A (p21(WAF1) (/) (CIP1) ) and SIRT1 genes. / 05.2015 / PubMed / Full text
Gene polymorphisms of cellular senescence marker p21 and disease progression in non-alcohol-related fatty liver disease. / 2014 / PubMed / Full text

DNMT1

DNA Methyltransferase 1 (DNMT1) Function Is Implicated in the Age-Related Loss of Cortical Interneurons. / 2020 / PubMed / Full text
Age-related Changes in the Global DNA Methylation Profile of Oligodendrocyte Progenitor Cells Derived from Rat Spinal Cords. / 02.2019 / PubMed / Full text
Epigallocatechin-3-gallate and BIX-01294 have different impact on epigenetics and senescence modulation in acute and chronic myeloid leukemia cells. / 05.11.2018 / PubMed / Full text
Resveratrol promotes oxidative stress to drive DLC1 mediated cellular senescence in cancer cells. / 15.09.2018 / PubMed / Full text
Ultraviolet A irradiation induces senescence in human dermal fibroblasts by down-regulating DNMT1 via ZEB1. / 16.02.2018 / PubMed / Full text
Microrna-217 modulates human skin fibroblast senescence by directly targeting DNA methyltransferase 1. / 16.05.2017 / PubMed / Full text
A positive feedback loop between Pim-1 kinase and HBP1 transcription factor contributes to hydrogen peroxide-induced premature senescence and apoptosis. / 19.05.2017 / PubMed / Full text
miR-377 induces senescence in human skin fibroblasts by targeting DNA methyltransferase 1. / 09.03.2017 / PubMed / Full text
Converting Adult Pancreatic Islet α Cells into β Cells by Targeting Both Dnmt1 and Arx. / 07.03.2017 / PubMed / Full text
The Ubiquitin-like with PHD and Ring Finger Domains 1 (UHRF1)/DNA Methyltransferase 1 (DNMT1) Axis Is a Primary Regulator of Cell Senescence. / 03.03.2017 / PubMed / Full text
Short term methionine restriction increases hepatic global DNA methylation in adult but not young male C57BL/6J mice. / 02.2017 / PubMed / Full text
In vivo and in silico studies to identify mechanisms associated with Nurr1 modulation following early life exposure to permethrin in rats. / 06.01.2017 / PubMed / Full text
Age-Related Changes in DNA Methylation Associated with Shifting Th1/Th2 Balance. / 12.2016 / PubMed / Full text
CDK4-CDK6 inhibitors induce autophagy-mediated degradation of DNMT1 and facilitate the senescence antitumor response. / 02.10.2016 / PubMed / Full text
Developmental lead exposure and lifespan alterations in epigenetic regulators and their correspondence to biomarkers of Alzheimer's disease. / 2016 / PubMed / Full text
Age-dependent expression of DNMT1 and DNMT3B in PBMCs from a large European population enrolled in the MARK-AGE study. / 08.2016 / PubMed / Full text
SIRT1 affects DNA methylation of polycomb group protein target genes, a hotspot of the epigenetic shift observed in ageing. / 24.06.2015 / PubMed / Full text
The Interplay Between miR-148a and DNMT1 Might be Exploited for Pancreatic Cancer Therapy. / 2015 / PubMed / Full text

DNMT3A

Epigenetic regulation of miR-29a/miR-30c/DNMT3A axis controls SOD2 and mitochondrial oxidative stress in human mesenchymal stem cells. / 09.09.2020 / PubMed / Full text
Collagens and DNA methyltransferases in mare endometrosis. / 09.2019 / PubMed / Full text
Age-related clonal haemopoiesis is associated with increased epigenetic age. / 19.08.2019 / PubMed / Full text
Alcohol Extracts From [i]Ganoderma lucidum[/i] Delay the Progress of Alzheimer's Disease by Regulating DNA Methylation in Rodents. / 2019 / PubMed / Full text
Targeted, Amplicon-Based, Next-Generation Sequencing to Detect Age-Related Clonal Hematopoiesis. / 2019 / PubMed / Full text
Clonal hematopoiesis: Genes and underlying mechanisms in cardiovascular disease development. / 06.2019 / PubMed / Full text
Concise Review: Age-Related Clonal Hematopoiesis: Stem Cells Tempting the Devil. / 09.2018 / PubMed / Full text
Effects of Parental Aging During Embryo Development and Adult Life: The Case of Nothobranchius furzeri. / 04.2018 / PubMed / Full text
Genetic Biomarkers on Age-Related Cognitive Decline. / 2017 / PubMed / Full text
An inflammatory environment containing TNFα favors Tet2-mutant clonal hematopoiesis. / 03.2018 / PubMed / Full text
Sequential acquisition of mutations in myelodysplastic syndromes. / 2017 / PubMed / Full text
How stable is repression of disallowed genes in pancreatic islets in response to metabolic stress? / 2017 / PubMed / Full text
miR-194 functions as a novel modulator of cellular senescence in mouse embryonic fibroblasts. / 03.2017 / PubMed / Full text
A primer for epigenetics of hematological malignancies. / 2016 / PubMed / Full text
Methylation of LOXL1 Promoter by DNMT3A in Aged Human Skin Fibroblasts. / 04.2017 / PubMed / Full text
Insight into the molecular pathophysiology of myelodysplastic syndromes: targets for novel therapy. / 10.2016 / PubMed / Full text
No association of the variant rs11887120 in DNMT3A with cognitive decline in individuals with mild cognitive impairment. / 05.2016 / PubMed / Full text
DNMT3A moderates cognitive decline in subjects with mild cognitive impairment: replicated evidence from two mild cognitive impairment cohorts. / 2015 / PubMed / Full text

E2F1

Regulation of E2F1 activity via PKA-mediated phosphorylations. / 2020 / PubMed / Full text
Astragaloside IV ameliorates radiation-induced senescence via antioxidative mechanism. / 08.2020 / PubMed / Full text
E2F1 mediates the downregulation of POLD1 in replicative senescence. / 07.2019 / PubMed / Full text
Low dose Emodin induces tumor senescence for boosting breast cancer chemotherapy via silencing NRARP. / 10.11.2018 / PubMed / Full text
Downregulation of FOXP1 correlates with tendon stem/progenitor cells aging. / 26.09.2018 / PubMed / Full text
Loss of circadian protein TIMELESS accelerates the progression of cellular senescence. / 18.09.2018 / PubMed / Full text
Transcriptional Repression of High-Mobility Group Box 2 by p21 in Radiation-Induced Senescence. / 30.04.2018 / PubMed / Full text
Genome-wide association study and annotating candidate gene networks affecting age at first calving in Nellore cattle. / 12.2017 / PubMed / Full text
Triptolide Promotes Senescence of Prostate Cancer Cells Through Histone Methylation and Heterochromatin Formation / 27.09.2017 / PubMed / Full text
Senescence-associated microRNAs target cell cycle regulatory genes in normal human lung fibroblasts. / 01.10.2017 / PubMed / Full text
Neuronal tetraploidization in the cerebral cortex correlates with reduced cognition in mice and precedes and recapitulates Alzheimer's-associated neuropathology. / 08.2017 / PubMed / Full text
Old age and the associated impairment of bones' adaptation to loading are associated with transcriptomic changes in cellular metabolism, cell-matrix interactions and the cell cycle. / 30.01.2017 / PubMed / Full text
Rac1-Mediated DNA Damage and Inflammation Promote Nf2 Tumorigenesis but Also Limit Cell-Cycle Progression. / 21.11.2016 / PubMed / Full text
The activation of OR51E1 causes growth suppression of human prostate cancer cells. / 26.07.2016 / PubMed / Full text
Foxo3 circular RNA promotes cardiac senescence by modulating multiple factors associated with stress and senescence responses. / 07.05.2017 / PubMed / Full text
CBX8 antagonizes the effect of Sirtinol on premature senescence through the AKT-RB-E2F1 pathway in K562 leukemia cells. / 22.01.2016 / PubMed / Full text
Nucleolar repression facilitates initiation and maintenance of senescence. / 2015 / PubMed / Full text
Targeted gene mutation of E2F1 evokes age-dependent synaptic disruption and behavioral deficits. / 06.2014 / PubMed / Full text

EPO

Regulation of muscle and metabolic physiology by hypothalamic erythropoietin independently of its peripheral action. / 02.2020 / PubMed / Full text
Red Blood Cell Lifespan Shortening in Patients with Early-Stage Chronic Kidney Disease. / 2019 / PubMed / Full text
Age-Dependent Systemic Effects of a Systemic Intermittent Hypoxic Therapy [i]In Vivo[/i]. / 09.2019 / PubMed / Full text
Erythropoietin does not improve fracture healing in aged mice. / 15.07.2019 / PubMed / Full text
Dose-response relationship of intermittent normobaric hypoxia to stimulate erythropoietin in the context of health promotion in young and old people. / 05.2019 / PubMed / Full text
rhEPO Enhances Cellular Anti-oxidant Capacity to Protect Long-Term Cultured Aging Primary Nerve Cells. / 08.2017 / PubMed / Full text
[Effects of recombinant human erythropoietin on brain-derived neurotrophic factor expression in different brain regions of aging rats]. / 20.04.2016 / PubMed / Full text
Warming Up to New Possibilities with the Capsaicin Receptor TRPV1: mTOR, AMPK, and Erythropoietin. / 2017 / PubMed / Full text
The Anti-Aging Effect of Erythropoietin via the ERK/Nrf2-ARE Pathway in Aging Rats. / 03.2017 / PubMed / Full text
Age-associated expression of erythropoietin and its receptor in rat spiral ganglion neurons and its association with neuronal apoptosis and hearing alterations. / 01.2017 / PubMed / Full text
Erythropoietin and mTOR: A "One-Two Punch" for Aging-Related Disorders Accompanied by Enhanced Life Expectancy. / 2016 / PubMed / Full text
Erythropoietin Does Not Enhance Skeletal Muscle Protein Synthesis Following Exercise in Young and Older Adults. / 2016 / PubMed / Full text
Oxidative stress induces the decline of brain EPO expression in aging rats. / 10.2016 / PubMed / Full text
Sub-acute systemic erythropoietin administration reduces ischemic brain injury in an age-dependent manner. / 14.06.2016 / PubMed / Full text
Erythropoietin Attenuates the Memory Deficits in Aging Rats by Rescuing the Oxidative Stress and Inflammation and Promoting BDNF Releasing. / 10.2016 / PubMed / Full text
rhEPO affects apoptosis in hippocampus of aging rats by upregulating SIRT1. / 2015 / PubMed / Full text
Coated dextrin microcapsules of amlodipine incorporable into orally disintegrating tablets for geriatric patients. / 10.2014 / PubMed / Full text
Neocytolysis: none, one or many? A reappraisal and future perspectives. / 2014 / PubMed / Full text

GAL

Overexpression of Pitx1 attenuates the senescence of chondrocytes from osteoarthritis degeneration cartilage-A self-controlled model for studying the etiology and treatment of osteoarthritis. / 02.2020 / PubMed / Full text
β-Caryophyllene Reduces DNA Oxidation and the Overexpression of Glial Fibrillary Acidic Protein in the Prefrontal Cortex and Hippocampus of d-Galactose-Induced Aged BALB/c Mice. / 05.2020 / PubMed / Full text
Senescence-associated β-galactosidase activity in the developing avian retina. / 09.2019 / PubMed / Full text
Zeaxanthin Isolated from [i]Dunaliella salina[/i] Microalgae Ameliorates Age Associated Cardiac Dysfunction in Rats through Stimulation of Retinoid Receptors. / 14.05.2019 / PubMed / Full text
Effects of sulforaphane on D-galactose-induced liver aging in rats: Role of keap-1/nrf-2 pathway. / 15.07.2019 / PubMed / Full text
MYC and RAS are unable to cooperate in overcoming cellular senescence and apoptosis in normal human fibroblasts. / 2018 / PubMed / Full text
Manipulation of molecular pathways and senescence hallmarks by natural compounds in fibroblast cells. / 04.2019 / PubMed / Full text
Ellagic acid reveals promising anti-aging effects against d-galactose-induced aging on human neuroblastoma cell line, SH-SY5Y: A mechanistic study. / 12.2018 / PubMed / Full text
Molecular and biochemical evidence on the protective role of ellagic acid and silybin against oxidative stress-induced cellular aging. / 04.2018 / PubMed / Full text
Hyperphosphatemia induces senescence in human endothelial cells by increasing endothelin-1 production. / 12.2017 / PubMed / Full text
Carnosine Treatment Diminished Oxidative Stress and Glycation Products in Serum and Tissues of D-Galactose-Treated Rats. / 2018 / PubMed / Full text
Oncogene-Induced Senescence in Pituitary Adenomas--an Immunohistochemical Study. / 03.2016 / PubMed / Full text
Carnosine and taurine treatments diminished brain oxidative stress and apoptosis in D-galactose aging model. / 04.2016 / PubMed / Full text
The role of TORC1 in muscle development in Drosophila. / 13.04.2015 / PubMed / Full text
N-ethyl-N-Nitrosourea (ENU) induced mutations within the klotho gene lead to ectopic calcification and reduced lifespan in mouse models. / 2015 / PubMed / Full text
Five years of interdisciplinary research on ageing and technology: Outcomes of the Lower Saxony Research Network Design of Environments for Ageing (GAL)--an introduction to this Special Issue on Ageing and Technology. / 09-12.2014 / PubMed / Full text
Information and communication technologies for promoting and sustaining quality of life, health and self-sufficiency in ageing societies--outcomes of the Lower Saxony Research Network Design of Environments for Ageing (GAL). / 09-12.2014 / PubMed / Full text
Cyanidin-3-O-galactoside and blueberry extracts supplementation improves spatial memory and regulates hippocampal ERK expression in senescence-accelerated mice. / 03.2014 / PubMed / Full text

NQO1

Augmentation of cellular NAD by NQO1 enzymatic action improves age-related hearing impairment. / 10.2019 / PubMed / Full text
Well-aging: A new strategy for skin homeostasis under multi-stressed conditions. / 02.2020 / PubMed / Full text
Limitations to adaptive homeostasis in an hyperoxia-induced model of accelerated ageing. / 06.2019 / PubMed / Full text
Link between cardiac function and the antioxidative defense mechanism in aged rats. / 11.06.2019 / PubMed / Full text
[Protective effect of Wuzi Yanzong recipe on testicular DNA oxidative damage in natural ageing rats]. / 07.2018 / PubMed / Full text
Benefits of Caloric Restriction in Longevity and Chemical-Induced Tumorigenesis Are Transmitted Independent of NQO1. / 16.01.2019 / PubMed / Full text
Overexpression of CYB5R3 and NQO1, two NAD -producing enzymes, mimics aspects of caloric restriction. / 08.2018 / PubMed / Full text
Sargassum fusiforme Polysaccharide Rejuvenat es the Small Intestine in Mice Through Altering its Physiol ogy and Gut Microbiota Composition. / 2017 / PubMed / Full text
Apigenin exhibits protective effects in a mouse model of d-galactose-induced aging via activating the Nrf2 pathway. / 21.06.2017 / PubMed / Full text
The ontogeny and population variability of human hepatic dihydronicotinamide riboside:quinone oxidoreductase (NQO2). / 08.2017 / PubMed / Full text
Gardenia jasminoides extract-capped gold nanoparticles reverse hydrogen peroxide-induced premature senescence. / 11.2016 / PubMed / Full text
Stimulation of cellular senescent processes, including secretory phenotypes and anti-oxidant responses, after androgen deprivation therapy in human prostate cancer. / 01.2017 / PubMed / Full text
Exercise-induced Nrf2-signaling is impaired in aging. / 07.2016 / PubMed / Full text
Abrogation of Nrf2 impairs antioxidant signaling and promotes atrial hypertrophy in response to high-intensity exercise stress. / 05.04.2016 / PubMed / Full text
The Ontogeny and Population Variability of Human Hepatic NADPH Dehydrogenase Quinone Oxido-Reductase 1 (NQO1). / 07.2016 / PubMed / Full text
Acetaminophen hepatotoxicity in mice: Effect of age, frailty and exposure type. / 01.2016 / PubMed / Full text
NQO1 Stabilizes p53 in Response to Oncogene-Induced Senescence. / 2015 / PubMed / Full text
Neophobia, NQO1 and SIRT1 as premorbid and prodromal indicators of AD in 3xTg-AD mice. / 01.09.2014 / PubMed / Full text

TREM2

Loss of TREM2 Confers Resilience to Synaptic and Cognitive Impairment in Aged Mice. / 09.12.2020 / PubMed / Full text
Triggering Receptor Expressed on Myeloid Cell 2 R47H Exacerbates Immune Response in Alzheimer's Disease Brain. / 2020 / PubMed / Full text
Knockdown of astrocytic TREM2 in the hippocampus relieves cognitive decline in elderly male mice. / 15.01.2021 / PubMed / Full text
Immune Signaling in Neurodegeneration. / 16.04.2019 / PubMed / Full text
The Triggering Receptor Expressed on Myeloid Cells-2 (TREM-2) as Expression of the Relationship between Microglia and Alzheimer's Disease: A Novel Marker for a Promising Pathway to Explore. / 2019 / PubMed / Full text
TREM2 triggers microglial density and age-related neuronal loss. / 03.2019 / PubMed / Full text
Differential effects of partial and complete loss of TREM2 on microglial injury response and tauopathy. / 02.10.2018 / PubMed / Full text
Whole-Exome Sequencing of an Exceptional Longevity Cohort. / 16.08.2019 / PubMed / Full text
Differential Phagocytic Properties of CD45 Microglia and CD45 Brain Mononuclear Phagocytes-Activation and Age-Related Effects. / 2018 / PubMed / Full text
Microglia and Aging: The Role of the TREM2-DAP12 and CX3CL1-CX3CR1 Axes. / 22.01.2018 / PubMed / Full text
A Tale of Two Genes: Microglial Apoe and Trem2. / 19.09.2017 / PubMed / Full text
TREM2, Microglia, and Neurodegenerative Diseases. / 06.2017 / PubMed / Full text
Neuroprotective Effect of TREM-2 in Aging and Alzheimer's Disease Model. / 2017 / PubMed / Full text
Cerebrospinal fluid soluble TREM2 in aging and Alzheimer's disease. / 27.04.2016 / PubMed / Full text
Chronic consumption of a western diet induces robust glial activation in aging mice and in a mouse model of Alzheimer's disease. / 18.02.2016 / PubMed / Full text
Dark microglia: A new phenotype predominantly associated with pathological states. / 05.2016 / PubMed / Full text
TREM2 Overexpression has No Improvement on Neuropathology and Cognitive Impairment in Aging APPswe/PS1dE9 Mice. / 03.2017 / PubMed / Full text
TREM2 sustains microglial expansion during aging and response to demyelination. / 05.2015 / PubMed / Full text

TSPO

Age and Sex Influence the Neuro-inflammatory Response to a Peripheral Acute LPS Challenge. / 2019 / PubMed / Full text
Upregulation of cannabinoid receptor type 2, but not TSPO, in senescence-accelerated neuroinflammation in mice: a positron emission tomography study. / 10.11.2019 / PubMed / Full text
Effects of age, BMI and sex on the glial cell marker [[TSPO]] - a multicentre [ C]PBR28 HRRT PET study. / 10.2019 / PubMed / Full text
Concentration, distribution, and influence of aging on the 18 kDa translocator protein in human brain: Implications for brain imaging studies. / 05.2020 / PubMed / Full text
Microglial response to increasing amyloid load saturates with aging: a longitudinal dual tracer in vivo μPET-study. / 06.11.2018 / PubMed / Full text
Age Influences Microglial Activation After Cuprizone-Induced Demyelination. / 2018 / PubMed / Full text
[[TSPO]] ligand PK11195 improves Alzheimer-related outcomes in aged female 3xTg-AD mice. / 14.09.2018 / PubMed / Full text
Imaging studies of the HIV-infected brain. / 2018 / PubMed / Full text
Steroidogenic abnormalities in translocator protein knockout mice and significance in the aging male. / 02.01.2018 / PubMed / Full text
Time Courses of Cortical Glucose Metabolism and Microglial Activity Across the Life Span of Wild-Type Mice: A PET Study. / 12.2017 / PubMed / Full text
Depiction of microglial activation in aging and dementia: Positron emission tomography with [ C]DPA713 versus [ C]( R)PK11195. / 03.2017 / PubMed / Full text
In Vivo Detection of Age- and Disease-Related Increases in Neuroinflammation by 18F-GE180 [[TSPO]] MicroPET Imaging in Wild-Type and Alzheimer's Transgenic Mice. / 25.11.2015 / PubMed / Full text
[[TSPO]] in a murine model of Sandhoff disease: presymptomatic marker of neurodegeneration and disease pathophysiology. / 01.2016 / PubMed / Full text
Translocator protein: pharmacology and steroidogenesis. / 08.2015 / PubMed / Full text
Translocator protein (TSPO) role in aging and Alzheimer's disease. / 2014 / PubMed / Full text
Evaluation of basal ganglia and thalamic inflammation in children with pediatric autoimmune neuropsychiatric disorders associated with streptococcal infection and tourette syndrome: a positron emission tomographic (PET) study using 11C-[R]-PK11195. / 05.2015 / PubMed / Full text
Genetic analysis of d[[TSPO]], an outer mitochondrial membrane protein, reveals its functions in apoptosis, longevity, and Ab42-induced neurodegeneration. / 06.2014 / PubMed / Full text
Comparing amyloid-β deposition, neuroinflammation, glucose metabolism, and mitochondrial complex I activity in brain: a PET study in aged monkeys. / 11.2014 / PubMed / Full text

UCP2

Potential Role of Leptin in Cardiac Steatosis Induced by Highly Saturated Fat Intake during Adolescence. / 10.2019 / PubMed / Full text
Effect of Initial Aging and High-Fat/High-Fructose Diet on Mitochondrial Bioenergetics and Oxidative Status in Rat Brain. / 11.2019 / PubMed / Full text
Decreased uncoupling protein 2 expression in aging retinal pigment epithelial cells. / 2019 / PubMed / Full text
The Role of Genetic Profile in Functional Performance Adaptations to Exercise Training or Physical Activity: A Systematic Review of the Literature. / 01.08.2019 / PubMed / Full text
G-1 exhibit antidepressant effect, increase of hippocampal ERs expression and improve hippocampal redox status in aged female rats. / 01.02.2019 / PubMed / Full text
Rapamycin increases oxidative metabolism and enhances metabolic flexibility in human cardiac fibroblasts. / 21.06.2018 / PubMed / Full text
Sestrin2 prevents age-related intolerance to post myocardial infarction via AMPK/PGC-1α pathway. / 02.2018 / PubMed / Full text
Pleiotropic effects of UCP2-UCP3 variability on leucocyte telomere length and glucose homeostasis. / 06.2017 / PubMed / Full text
Thyroid hormone-stimulated increases in PGC-1α and UCP2 promote life history-specific endocrine changes and maintain a lipid-based metabolism. / 01.02.2017 / PubMed / Full text
Uncoupling protein 2 deficiency results in higher neutrophil counts and lower B-cell counts during aging in mice. / 11.2016 / PubMed / Full text
Voluntary Running Aids to Maintain High Body Temperature in Rats Bred for High Aerobic Capacity. / 2016 / PubMed / Full text
Uncoupling protein 2 protects mice from aging. / 09.2016 / PubMed / Full text
Single nucleotide polymorphisms linked to mitochondrial uncoupling protein genes UCP2 and UCP3 affect mitochondrial metabolism and healthy aging in female nonagenarians. / 08.2016 / PubMed / Full text
Differential modulation of AMPK/PPARα/UCP2 axis in relation to hypertension and aging in the brain, kidneys and heart of two closely related spontaneously hypertensive rat strains. / 07.08.2015 / PubMed / Full text
[Genotype and allele frequencies of UCP and PPAR gene families in residents of besieged Leningrad and in the control group]. / 2014 / PubMed
Activation of PPAR-γ by pioglitazone attenuates oxidative stress in aging rat cerebral arteries through upregulating UCP2. / 12.2014 / PubMed / Full text
Loss of UCP2 attenuates mitochondrial dysfunction without altering ROS production and uncoupling activity. / 06.2014 / PubMed / Full text
Contribution of genetic polymorphisms on functional status at very old age: a gene-based analysis of 38 genes (311 SNPs) in the oxidative stress pathway. / 04.2014 / PubMed / Full text

CXCL10

Age-related decline of interferon-gamma responses in macrophage impairs satellite cell proliferation and regeneration. / 10.2020 / PubMed / Full text
Neuroprotective effects of targeting BET proteins for degradation with dBET1 in aged mice subjected to ischemic stroke. / 07.2019 / PubMed / Full text
Towards frailty biomarkers: Candidates from genes and pathways regulated in aging and age-related diseases. / 11.2018 / PubMed / Full text
Age-related pro-inflammatory and pro-angiogenic changes in human aqueous humor. / 2018 / PubMed / Full text
Aged Chinese-origin rhesus macaques infected with SIV develop marked viremia in absence of clinical disease, inflammation or cognitive impairment. / 01.02.2018 / PubMed / Full text
Immune senescence and biomarkers profile of Bambuí aged population-based cohort. / 03.2018 / PubMed / Full text
Dysregulation of C-X-C motif ligand 10 during aging and association with cognitive performance. / 03.2018 / PubMed / Full text
Selected life-extending interventions reduce arterial CXCL10 and macrophage colony-stimulating factor in aged mouse arteries. / 08.2017 / PubMed / Full text
Interferon-gamma deficiency protects against aging-related goblet cell loss. / 04.10.2016 / PubMed / Full text
Behaviour and cognitive changes correlated with hippocampal neuroinflammaging and neuronal markers in female SAMP8, a model of accelerated senescence. / 07.2016 / PubMed / Full text
In vitro cytokine induction by TLR-activating vaccine adjuvants in human blood varies by age and adjuvant. / 07.2016 / PubMed / Full text
Thinning of the RPE and choroid associated with T lymphocyte recruitment in aged and light-challenged mice. / 2015 / PubMed / Full text
CCL2, CXCL8, CXCL9 and CXCL10 serum levels increase with age but are not altered by treatment with hydroxychloroquine in patients with osteoarthritis of the knees. / 12.2017 / PubMed / Full text
Cathelicidin related antimicrobial peptide, laminin, Toll-like receptors and chemokines levels in experimental hypersensitivity pneumonitis in mice. / 06.2015 / PubMed / Full text
Viremic and Virologically Suppressed HIV Infection Increases Age-Related Changes to Monocyte Activation Equivalent to 12 and 4 Years of Aging, Respectively. / 01.05.2015 / PubMed / Full text
Increased recruitment of bone marrow-derived cells into the brain associated with altered brain cytokine profile in senescence-accelerated mice. / 04.2016 / PubMed / Full text
Dendritic cells from aged subjects contribute to chronic airway inflammation by activating bronchial epithelial cells under steady state. / 11.2014 / PubMed / Full text

FAS

Five-year change in maximum tongue pressure and physical function in community-dwelling elderly adults. / 09.2020 / PubMed / Full text
Inhibition of USP7 activity selectively eliminates senescent cells in part via restoration of p53 activity. / 03.2020 / PubMed / Full text
Application of GFR estimation equations in elderly patients with measured GFR below 60 mL/min/1.73 m . / 03.2020 / PubMed / Full text
Dietary methionine increased the lipid accumulation in juvenile tiger puffer Takifugu rubripes. / 04.2019 / PubMed / Full text
Genetic and Environmental Influences on Language Ability in Older Adults: Findings from the Older Australian Twins Study. / 05.2018 / PubMed / Full text
Effects of aging on fat deposition and meat quality in Sheldrake duck. / 01.06.2018 / PubMed / Full text
Impact of sociodemographic variables on executive functions. / 01-03.2017 / PubMed / Full text
Prevalence of Impaired Kidney Function in the German Elderly: Results from the Berlin Aging Study II (BASE-II). / 2017 / PubMed / Full text
Multiple category verbal fluency in mild cognitive impairment and correlation with CSF biomarkers for Alzheimer's disease. / 06.2017 / PubMed / Full text
Glomerular Filtration Rate in Healthy Living Potential Kidney Donors: A Meta-Analysis Supporting the Construction of the Full Age Spectrum Equation. / 2017 / PubMed / Full text
Life Expectancy of People with Fetal Alcohol Syndrome. / 2016 / PubMed
Increased susceptibility of CD4 T cells from elderly individuals to HIV-1 infection and apoptosis is associated with reduced CD4 and enhanced CXCR4 and FAS surface expression levels. / 09.10.2015 / PubMed / Full text
Systemic Akt1 Deletion after Tumor Onset in p53(-/-) Mice Increases Lifespan and Regresses Thymic Lymphoma Emulating p53 Restoration. / 28.07.2015 / PubMed / Full text
Impact of loss of NF-κB1, NF-κB2 or c-REL on SLE-like autoimmune disease and lymphadenopathy in Fas(lpr/lpr) mutant mice. / 01.2016 / PubMed / Full text
Longitudinal measures of perfluoroalkyl substances (PFAS) in serum of Gullah African Americans in South Carolina: 2003-2013. / 11.2015 / PubMed / Full text
White Adipose Tissue Depot-Specific Activity of Lipogenic Enzymes in Response to Fasting and Refeeding in Young and Old Rats. / 2015 / PubMed / Full text
Short-term calorie restriction and refeeding differently affect lipogenic enzymes in major white adipose tissue depots of young and old rats. / 02.2014 / PubMed

FH

Genetic Factors of Alzheimer's Disease Modulate How Diet is Associated with Long-Term Cognitive Trajectories: A UK Biobank Study. / 2020 / PubMed / Full text
Volumetric alterations in the hippocampal subfields of subjects at increased risk of dementia. / 07.2020 / PubMed / Full text
Macroscopic hematuria as a risk factor for hypertension in ageing people with hemophilia and a family history of hypertension. / 02.2020 / PubMed / Full text
LDL Receptor Deficiency Does not Alter Brain Amyloid-β Levels but Causes an Exacerbation of Apoptosis. / 2020 / PubMed / Full text
Sex differences in cholesterol levels from birth to 19 years of age may lead to increased cholesterol burden in females with FH. / 05-06.2018 / PubMed / Full text
Association between lipoprotein (a) and proprotein convertase substilisin/kexin type 9 in patients with heterozygous familial hypercholesterolemia: A case-control study. / 02.2018 / PubMed / Full text
Longitudinal Assessment of Self- and Informant-Subjective Cognitive Complaints in a Sample of Healthy Late-Middle Aged Adults Enriched with a Family History of Alzheimer's Disease. / 09.2017 / PubMed / Full text
Diffusion Tensor Imaging Predictors of Episodic Memory Decline in Healthy Elders at Genetic Risk for Alzheimer's Disease. / 11.2016 / PubMed / Full text
Familial hypercholesterolaemia reduces the quality of life of patients not reaching treatment targets. / 05.2016 / PubMed
Effect of fetal hypothyroidism on tolerance to ischemia-reperfusion injury in aged male rats: Role of nitric oxide. / 01.05.2016 / PubMed / Full text
Familial hypercholesterolaemia in children and adolescents: gaining decades of life by optimizing detection and treatment. / 21.09.2015 / PubMed / Full text
Impact of family history of alcoholism on glutamine/glutamate ratio in anterior cingulate cortex in substance-naïve adolescents. / 12.2015 / PubMed / Full text
Age-Based Differences in the Genetic Determinants of Glycemic Control: A Case of FOXO3 Variations. / 2015 / PubMed / Full text
The Mechanism of Ligamentum Flavum Hypertrophy: Introducing Angiogenesis as a Critical Link That Couples Mechanical Stress and Hypertrophy. / 08.2015 / PubMed / Full text
Longitudinal measures of perfluoroalkyl substances (PFAS) in serum of Gullah African Americans in South Carolina: 2003-2013. / 11.2015 / PubMed / Full text
FDG and Amyloid PET in Cognitively Normal Individuals at Risk for Late-Onset Alzheimer's Disease. / 04.2014 / PubMed / Full text
Randomized trial of the ForeseeHome monitoring device for early detection of neovascular age-related macular degeneration. The HOme Monitoring of the Eye (HOME) study design - HOME Study report number 1. / 03.2014 / PubMed / Full text

GDNF

GFR-α1 Expression in Substantia Nigra Increases Bilaterally Following Unilateral Striatal GDNF in Aged Rats and Attenuates Nigral Tyrosine Hydroxylase Loss Following 6-OHDA Nigrostriatal Lesion. / 16.10.2019 / PubMed / Full text
The Gender-Biased Effects of Intranasal MPTP Administration on Anhedonic- and Depressive-Like Behaviors in C57BL/6 Mice: the Role of Neurotrophic Factors. / 11.2018 / PubMed / Full text
Analysis of neurotrophic and antioxidant factors related to midbrain dopamine neuronal loss and brain inflammation in the cerebrospinal fluid of the elderly. / 09.2018 / PubMed / Full text
Glial cell line-derived neurotrophic factor (GDNF) attenuates the peripheral neuromuscular dysfunction without inhibiting the activation of spinal microglia/monocyte. / 09.05.2018 / PubMed / Full text
Aging-related limit of exercise efficacy on motor decline. / 2017 / PubMed / Full text
The Noradrenergic System of Aged GDNF Heterozygous Mice. / 04.2003 / PubMed / Full text
Age-associated decrease in GDNF and its cognate receptor GFRα-1 protein expression in human skin. / 06.2016 / PubMed / Full text
Effect of age on expression of spermatogonial markers in bovine testis and isolated cells. / 07.2016 / PubMed / Full text
Human neural progenitors differentiate into astrocytes and protect motor neurons in aging rats. / 06.2016 / PubMed / Full text
Exercise-Mediated Increase in Nigral Tyrosine Hydroxylase Is Accompanied by Increased Nigral GFR-α1 and EAAC1 Expression in Aging Rats. / 17.02.2016 / PubMed / Full text
Mechanisms of Muscle Denervation in Aging: Insights from a Mouse Model of Amyotrophic Lateral Sclerosis. / 09.2015 / PubMed / Full text
The involvement of BDNF, NGF and GDNF in aging and Alzheimer's disease. / 09.2015 / PubMed / Full text
Symptomatic improvement, increased life-span and sustained cell homing in amyotrophic lateral sclerosis after transplantation of human umbilical cord blood cells genetically modified with adeno-viral vectors expressing a neuro-protective factor and a neural cell adhesion molecule. / 2015 / PubMed / Full text
Effects of aging on glutamate neurotransmission in the substantia nigra of Gdnf heterozygous mice. / 03.2015 / PubMed / Full text
Age and lesion-induced increases of GDNF transgene expression in brain following intracerebral injections of DNA nanoparticles. / 22.01.2015 / PubMed / Full text
Astrocytes show reduced support of motor neurons with aging that is accelerated in a rodent model of ALS. / 02.2015 / PubMed / Full text
GDNF and GFRα co-receptor family in the developing feline gut. / 09.2014 / PubMed / Full text

KLF4

Extracellular Vesicles from Healthy Cells Improves Cell Function and Stemness in Premature Senescent Stem Cells by miR-302b and HIF-1α Activation. / 25.06.2020 / PubMed / Full text
Soluble klotho regulates the function of salivary glands by activating KLF4 pathways. / 02.10.2019 / PubMed / Full text
Centenarians Overexpress Pluripotency-Related Genes. / 16.08.2019 / PubMed / Full text
A SIRT1-centered circuitry regulates breast cancer stemness and metastasis. / 12.2018 / PubMed / Full text
miR-10a rejuvenates aged human mesenchymal stem cells and improves heart function after myocardial infarction through KLF4. / 30.05.2018 / PubMed / Full text
MYC Releases Early Reprogrammed Human Cells from Proliferation Pause via Retinoblastoma Protein Inhibition. / 10.04.2018 / PubMed / Full text
Kruppel-like factor 4 regulates keratinocyte senescence. / 05.05.2018 / PubMed / Full text
Role of CD133 Molecule in Wnt Response and Renal Repair. / 03.2018 / PubMed / Full text
Coupling shRNA screens with single-cell RNA-seq identifies a dual role for mTOR in reprogramming-induced senescence. / 15.10.2017 / PubMed / Full text
ZSCAN10 expression corrects the genomic instability of iPSCs from aged donors. / 09.2017 / PubMed / Full text
Induced Pluripotent Stem Cell-Derived Dopaminergic Neurons from Adult Common Marmoset Fibroblasts. / 01.09.2017 / PubMed / Full text
Role of p16 and BMI-1 in oxidative stress-induced premature senescence in human dental pulp stem cells. / 08.2017 / PubMed / Full text
Overexpression of KLF4 promotes cell senescence through microRNA-203-survivin-p21 pathway. / 13.09.2016 / PubMed / Full text
Adipose-derived stem cells from lean and obese humans show depot specific differences in their stem cell markers, exosome contents and senescence: role of protein kinase C delta (PKCδ) in adipose stem cell niche. / 2016 / PubMed / Full text
KLF4 deletion alters gastric cell lineage and induces MUC2 expression. / 09.06.2016 / PubMed / Full text
Critical role of the miR-200 family in regulating differentiation and proliferation of neurons. / 06.2015 / PubMed / Full text
Oxidative DNA damage causes premature senescence in mouse embryonic fibroblasts deficient for Krüppel-like factor 4. / 09.2015 / PubMed / Full text

LPO

[Features of the changes in lipid peroxidation and activity of Na /K -ATPase in the brain of the aged rats in the conditions of two-vessel cerebral ischemia/reperfusion.] / 2019 / PubMed
Exercise training initiated at old stage of lifespan attenuates aging-and ovariectomy-induced cardiac and renal oxidative stress: Role of baroreflex. / 09.2019 / PubMed / Full text
Tris(1,3-dichloro-2-propyl) phosphate accelerated the aging process induced by the 4-hydroxynon-2-enal response to reactive oxidative species in Caenorhabditis elegans. / 03.2019 / PubMed / Full text
Physical Exercise Attenuates Oxidative Stress and Morphofunctional Cerebellar Damages Induced by the Ethanol Binge Drinking Paradigm from Adolescence to Adulthood in Rats. / 2019 / PubMed / Full text
[Effect of cryopreserved cord blood nucleated cells on course of pathological processes in progressive aging of brain (experimental study).] / 2018 / PubMed
Analysis of Plasma MicroRNAs as Predictors and Biomarkers of Aging and Frailty in Humans. / 2018 / PubMed / Full text
ERCC1-deficient cells and mice are hypersensitive to lipid peroxidation. / 20.08.2018 / PubMed / Full text
Antioxidant action of grape seed polyphenols and aerobic exercise in improving neuronal number in the hippocampus is associated with decrease in lipid peroxidation and hydrogen peroxide in adult and middle-aged rats. / 01.2018 / PubMed / Full text
The antioxidative and anti-aging effects of acidic- and alkalic-extractable mycelium polysaccharides by Agrocybe aegerita (Brig.) Sing. / 01.2018 / PubMed / Full text
Aging modifies daily variation of antioxidant enzymes and oxidative status in the hippocampus. / 02.2017 / PubMed / Full text
Lipid peroxidation in face of DNA damage, DNA repair and other cellular processes. / 06.2017 / PubMed / Full text
An iron-deficient diet during development induces oxidative stress in relation to age and gender in Wistar rats. / 02.2017 / PubMed / Full text
Age-Dependent Changes in Na( ),K( )-ATPase Activity and Lipid Peroxidation in Membranes of Erythrocytes during Cardiosclerosis Development in Rats. / 06.2016 / PubMed / Full text
Purple sweet potato anthocyanin attenuates fat-induced mortality in Drosophila melanogaster. / 09.2016 / PubMed / Full text
n-3 fatty acids effectively improve the reference memory-related learning ability associated with increased brain docosahexaenoic acid-derived docosanoids in aged rats. / 02.2015 / PubMed / Full text
Pectinase-treated Panax ginseng extract (GINST) rescues testicular dysfunction in aged rats via redox-modulating proteins. / 05.2014 / PubMed / Full text
Antioxidant role of oleuropein on midbrain and dopaminergic neurons of substantia nigra in aged rats. / 2014 / PubMed / Full text

MTR

Amide proton transfer-weighted magnetic resonance imaging of human brain aging at 3 Tesla. / 03.2020 / PubMed / Full text
One-carbon metabolism gene polymorphisms are associated with cognitive trajectory among African-American adults. / 12.2019 / PubMed / Full text
Test-retest reliability of myelin imaging in the human spinal cord: Measurement errors versus region- and aging-induced variations. / 2018 / PubMed / Full text
Alterations in brain white matter contributing to age-related slowing of task switching performance: The role of radial diffusivity and magnetization transfer ratio. / 11.2016 / PubMed / Full text
Development and aging of superficial white matter myelin from young adulthood to old age: Mapping by vertex-based surface statistics (VBSS). / 05.2016 / PubMed / Full text
Moderate treadmill running exercise prior to tendon injury enhances wound healing in aging rats. / 23.02.2016 / PubMed / Full text
Nutritional habits, lifestyle, and genetic predisposition in cardiovascular and metabolic traits in Turkish population. / 06.2016 / PubMed / Full text
Age-effects in white matter using associated diffusion tensor imaging and magnetization transfer ratio during late childhood and early adolescence. / 05.2016 / PubMed / Full text
Associations between insulin action and integrity of brain microstructure differ with familial longevity and with age. / 2015 / PubMed / Full text
An in vivo study on brain microstructure in biological and chronological ageing. / 2015 / PubMed / Full text
White matter hyperintensities and normal-appearing white matter integrity in the aging brain. / 02.2015 / PubMed / Full text
Structural covariance of superficial white matter in mild Alzheimer's disease compared to normal aging. / 09.2014 / PubMed / Full text
Magnetization transfer ratio relates to cognitive impairment in normal elderly. / 2014 / PubMed / Full text
Gender, age-related, and regional differences of the magnetization transfer ratio of the cortical and subcortical brain gray matter. / 08.2014 / PubMed / Full text
Age independently affects myelin integrity as detected by magnetization transfer magnetic resonance imaging in multiple sclerosis. / 2014 / PubMed / Full text
Magnetization transfer imaging for in vivo detection of microstructural tissue changes in aging and dementia: a short literature review. / 2014 / PubMed / Full text
Quantitative multi-modal MRI of the Hippocampus and cognitive ability in community-dwelling older subjects. / 04.2014 / PubMed / Full text

NOX4

Sestrin2 Attenuates Cellular Senescence by Inhibiting NADPH Oxidase 4 Expression. / 24.11.2020 / PubMed / Full text
NADPH Oxidases and Aging Models of Lung Fibrosis. / 2019 / PubMed / Full text
Age-related distribution and potential role of SNCB in topographically different retinal areas of the common marmoset Callithrix jacchus, including the macula. / 08.2019 / PubMed / Full text
Expression of lipogenic markers is decreased in subcutaneous adipose tissue and adipocytes of older women and is negatively linked to GDF15 expression. / 08.2019 / PubMed / Full text
Redox Imbalance in Idiopathic Pulmonary Fibrosis: A Role for Oxidant Cross-Talk Between NADPH Oxidase Enzymes and Mitochondria. / 10.11.2019 / PubMed / Full text
NADPH oxidase 4 mediates ROS production in radiation-induced senescent cells and promotes migration of inflammatory cells. / 01.2018 / PubMed / Full text
Alternative Splicing of NOX4 in the Failing Human Heart. / 2017 / PubMed / Full text
Cooperation between p21 and Akt is required for p53-dependent cellular senescence. / 10.2017 / PubMed / Full text
Mcl-1 regulates reactive oxygen species via NOX4 during chemotherapy-induced senescence. / 25.04.2017 / PubMed / Full text
PPARα activation by MHY908 attenuates age-related renal inflammation through modulation of the ROS/Akt/FoxO1 pathway. / 06.2017 / PubMed / Full text
NADPH oxidase 4 regulates vascular inflammation in aging and atherosclerosis. / 01.2017 / PubMed / Full text
NOX4 downregulation leads to senescence of human vascular smooth muscle cells. / 11.10.2016 / PubMed / Full text
Reactive oxygen species: The good, the bad, and the enigma. / 07-09.2014 / PubMed / Full text
Interferon gamma/NADPH oxidase defense system in immunity and cancer. / 02.2016 / PubMed / Full text
NOS1 induces NADPH oxidases and impairs contraction kinetics in aged murine ventricular myocytes. / 09.2015 / PubMed / Full text
NOX4 NADPH Oxidase-Dependent Mitochondrial Oxidative Stress in Aging-Associated Cardiovascular Disease. / 20.12.2015 / PubMed / Full text
The imbalanced redox status in senescent endothelial cells is due to dysregulated Thioredoxin-1 and NADPH oxidase 4. / 08.2014 / PubMed / Full text

PARP1

Topological DNA damage, telomere attrition and T cell senescence during chronic viral infections. / 2019 / PubMed / Full text
PARP1 inhibitor (PJ34) improves the function of aging-induced endothelial progenitor cells by preserving intracellular NAD levels and increasing SIRT1 activity. / 23.08.2018 / PubMed / Full text
Maternal high calorie diet induces mitochondrial dysfunction and senescence phenotype in subcutaneous fat of newborn mice. / 13.10.2017 / PubMed / Full text
Acute telomerase components depletion triggers oxidative stress as an early event previous to telomeric shortening. / 04.2018 / PubMed / Full text
Molecular evolutionary patterns of NAD /Sirtuin aging signaling pathway across taxa. / 2017 / PubMed / Full text
The NAD /PARP1/SIRT1 Axis in Aging. / 06.2017 / PubMed / Full text
A conserved NAD binding pocket that regulates protein-protein interactions during aging. / 24.03.2017 / PubMed / Full text
Melatonin regulates PARP1 to control the senescence-associated secretory phenotype (SASP) in human fetal lung fibroblast cells. / 08.2017 / PubMed / Full text
The Ubiquitin-like with PHD and Ring Finger Domains 1 (UHRF1)/DNA Methyltransferase 1 (DNMT1) Axis Is a Primary Regulator of Cell Senescence. / 03.03.2017 / PubMed / Full text
A serum miRNA profile of human longevity: findings from the Baltimore Longitudinal Study of Aging (BLSA). / 07.11.2016 / PubMed / Full text
Cockayne syndrome group A and B proteins converge on transcription-linked resolution of non-B DNA. / 01.11.2016 / PubMed / Full text
Sperm-associated antigen 9 (SPAG9) promotes the survival and tumor growth of triple-negative breast cancer cells. / 10.2016 / PubMed / Full text
Differential cytotoxicity induced by the Titanium(IV)Salan complex Tc52 in G2-phase independent of DNA damage. / 13.07.2016 / PubMed / Full text
All-trans retinoic acid and rapamycin normalize Hutchinson Gilford progeria fibroblast phenotype. / 06.10.2015 / PubMed / Full text
SIRT6 rescues the age related decline in base excision repair in a PARP1-dependent manner. / 2015 / PubMed / Full text
RecQ helicases and PARP1 team up in maintaining genome integrity. / 09.2015 / PubMed / Full text
Mechanisms controlling the smooth muscle cell death in progeria via down-regulation of poly(ADP-ribose) polymerase 1. / 03.06.2014 / PubMed / Full text

ADAM10

NKG2D Ligand Shedding in Response to Stress: Role of ADAM10. / 2020 / PubMed / Full text
Chronic Mild Stress Modified Epigenetic Mechanisms Leading to Accelerated Senescence and Impaired Cognitive Performance in Mice. / 10.02.2020 / PubMed / Full text
Removal of p75 Neurotrophin Receptor Expression from Cholinergic Basal Forebrain Neurons Reduces Amyloid-β Plaque Deposition and Cognitive Impairment in Aged APP/PS1 Mice. / 07.2019 / PubMed / Full text
11β-HSD1 Inhibition by RL-118 Promotes Autophagy and Correlates with Reduced Oxidative Stress and Inflammation, Enhancing Cognitive Performance in SAMP8 Mouse Model. / 12.2018 / PubMed / Full text
Effects of senescence and angiotensin II on expression and processing of amyloid precursor protein in human cerebral microvascular endothelial cells. / 15.01.2018 / PubMed / Full text
microRNA 221 Targets ADAM10 mRNA and is Downregulated in Alzheimer's Disease. / 2018 / PubMed / Full text
Human Plasma Thioredoxin-80 Increases With Age and in ApoE Mice Induces Inflammation, Angiogenesis, and Atherosclerosis. / 01.08.2017 / PubMed / Full text
Ionizing radiation reduces ADAM10 expression in brain microvascular endothelial cells undergoing stress-induced senescence. / 04.2017 / PubMed / Full text
Regulation of Alpha-Secretase ADAM10 [i]In vitro[/i] and [i]In vivo[/i]: Genetic, Epigenetic, and Protein-Based Mechanisms. / 2017 / PubMed / Full text
Sideritis spp. Extracts Enhance Memory and Learning in Alzheimer's β-Amyloidosis Mouse Models and Aged C57Bl/6 Mice. / 31.05.2016 / PubMed / Full text
Effects of Sesaminol Feeding on Brain Aβ Accumulation in a Senescence-Accelerated Mouse-Prone 8. / 22.06.2016 / PubMed / Full text
Behaviour and cognitive changes correlated with hippocampal neuroinflammaging and neuronal markers in female SAMP8, a model of accelerated senescence. / 07.2016 / PubMed / Full text
Epigenetic mechanisms underlying cognitive impairment and Alzheimer disease hallmarks in 5XFAD mice. / 04.2016 / PubMed / Full text
Increase of α-Secretase ADAM10 in Platelets Along Cognitively Healthy Aging. / 2016 / PubMed / Full text
ADAM10 gene expression in the blood cells of Alzheimer's disease patients and mild cognitive impairment subjects. / 2015 / PubMed / Full text
Serum Fragments of Tau for the Differential Diagnosis of Alzheimer's Disease. / 2015 / PubMed / Full text

ALDH2

Aldehyde Dehydrogenase 2 (ALDH2) and Aging: Is There a Sensible Link? / 2019 / PubMed / Full text
Appropriate dose of ethanol exerts anti-senescence and anti-atherosclerosis protective effects by activating ALDH2. / 30.04.2019 / PubMed / Full text
Impaired enzymatic reactive aldehyde-detoxifying capacity and glutathione peroxidase activity in the aged human arterial tissue. / 02.2019 / PubMed / Full text
Telomere shortening in alcohol dependence: Roles of alcohol and acetaldehyde. / 02.2019 / PubMed / Full text
Aldehyde dehydrogenase 2 deficiency promotes atherosclerotic plaque instability through accelerating mitochondrial ROS-mediated vascular smooth muscle cell senescence. / 01.07.2019 / PubMed / Full text
ALDH2 mediates the dose-response protection of chronic ethanol against endothelial senescence through SIRT1/p53 pathway. / 12.10.2018 / PubMed / Full text
Effects of the common polymorphism in the human aldehyde dehydrogenase 2 (ALDH2) gene on the lung. / 21.04.2017 / PubMed / Full text
Complex inhibition of autophagy by mitochondrial aldehyde dehydrogenase shortens lifespan and exacerbates cardiac aging. / 08.2017 / PubMed / Full text
Behaviour and cognitive changes correlated with hippocampal neuroinflammaging and neuronal markers in female SAMP8, a model of accelerated senescence. / 07.2016 / PubMed / Full text
Associations Between Alcohol Consumption and Leukocyte Telomere Length Modified by a Common Polymorphism of ALDH2. / 04.2016 / PubMed / Full text
Relationships of alcohol dehydrogenase 1B (ADH1B) and aldehyde dehydrogenase 2 (ALDH2) genotypes with alcohol sensitivity, drinking behavior and problem drinking in Japanese older men. / 05.2016 / PubMed / Full text
Aldehyde dehydrogenase 2 activation in aged heart improves the autophagy by reducing the carbonyl modification on SIRT1. / 19.01.2016 / PubMed / Full text
Characterization of Aldh2 (-/-) mice as an age-related model of cognitive impairment and Alzheimer's disease. / 25.04.2015 / PubMed / Full text
Ethanol reduces lifespan, body weight, and serum alanine aminotransferase level of aldehyde dehydrogenase 2 knockout mouse. / 07.2014 / PubMed / Full text
Mitochondrial aldehyde dehydrogenase 2 accentuates aging-induced cardiac remodeling and contractile dysfunction: role of AMPK, Sirt1, and mitochondrial function. / 06.2014 / PubMed / Full text
Targeting aldehyde dehydrogenase 2: new therapeutic opportunities. / 01.2014 / PubMed / Full text

BCR

The presence of CLL-associated stereotypic B cell receptors in the normal BCR repertoire from healthy individuals increases with age. / 2019 / PubMed / Full text
Crucial Role of Increased Arid3a at the Pre-B and Immature B Cell Stages for B1a Cell Generation. / 2019 / PubMed / Full text
Effect of Age on NK Cell Compartment in Chronic Myeloid Leukemia Patients Treated With Tyrosine Kinase Inhibitors. / 2018 / PubMed / Full text
B cell responses to apoptotic cells in MFG-E8-/- mice. / 2018 / PubMed / Full text
Early Generated B-1-Derived B Cells Have the Capacity To Progress To Become Mantle Cell Lymphoma-like Neoplasia in Aged Mice. / 15.07.2018 / PubMed / Full text
Mean residual life regression with functional principal component analysis on longitudinal data for dynamic prediction. / 12.2018 / PubMed / Full text
NLR Nod1 signaling promotes survival of BCR-engaged mature B cells through up-regulated Nod1 as a positive outcome. / 02.10.2017 / PubMed / Full text
Phylogenetic analysis of the human antibody repertoire reveals quantitative signatures of immune senescence and aging. / 31.01.2017 / PubMed / Full text
Immunosenescence-Related Transcriptomic and Immunologic Changes in Older Individuals Following Influenza Vaccination. / 2016 / PubMed / Full text
4-methylumbelliferone and imatinib combination enhances senescence induction in chronic myeloid leukemia cell lines. / 02.2017 / PubMed / Full text
Hyaluronan oligomers sensitize chronic myeloid leukemia cell lines to the effect of Imatinib. / 04.2016 / PubMed / Full text
Aging-associated inflammation promotes selection for adaptive oncogenic events in B cell progenitors. / 12.2015 / PubMed / Full text
The ageing human B cell repertoire: a failure of selection? / 01.2016 / PubMed / Full text
Age stratified comparative analysis of perioperative, functional and oncologic outcomes in patients after robot assisted radical prostatectomy--A propensity score matched study. / 07.2015 / PubMed / Full text
Double negative (CD19 IgG IgD-CD27-) B lymphocytes: a new insight from telomerase in healthy elderly, in centenarian offspring and in Alzheimer's disease patients. / 11.2014 / PubMed / Full text
Memory B cells form in aged mice despite impaired affinity maturation and germinal center kinetics. / 06.2014 / PubMed / Full text

CD19

Sequential treatment with aT19 cells generates memory CAR-T cells and prolongs the lifespan of Raji-B-NDG mice. / 28.01.2020 / PubMed / Full text
Stress-Induced Premature Senescence Promotes Proliferation by Activating the [i]SENEX[/i] and p16 /Retinoblastoma (Rb) Pathway in Diffuse Large B-Cell Lymphoma / 18.11.2019 / PubMed / Full text
Effects of pepsin and pepstatin on reflux tonsil hypertrophy in vitro. / 2018 / PubMed / Full text
Innate and adaptive immune dysregulation in critically ill ICU patients. / 05.07.2018 / PubMed / Full text
Vitamin D levels correlate with lymphocyte subsets in elderly patients with age-related diseases. / 16.05.2018 / PubMed / Full text
Normal variation of bone marrow B-cell precursors according to age - reference ranges for studies in myelodysplastic syndromes in Brazil. / 09.2018 / PubMed / Full text
Altered marginal zone and innate-like B cells in aged senescence-accelerated SAMP8 mice with defective IgG1 responses. / 17.08.2017 / PubMed / Full text
Different therapeutic effects of cells derived from human amniotic membrane on premature ovarian aging depend on distinct cellular biological characteristics. / 27.07.2017 / PubMed / Full text
Immune biomarkers in older adults: Role of physical activity. / 2017 / PubMed / Full text
A lifetime aging study of human CD19 transgenic mice. / 06.2017 / PubMed / Full text
Age-related arterial immune cell infiltration in mice is attenuated by caloric restriction or voluntary exercise. / 08.2018 / PubMed / Full text
Alterations in B-cell subsets in pediatric patients with early atopic dermatitis. / 07.2017 / PubMed / Full text
Perturbed hematopoiesis in mice lacking ATMIN. / 20.10.2016 / PubMed / Full text
Effects of Ageing on the Immune System: Infants to Elderly. / 04.2016 / PubMed / Full text
Exome sequencing analysis reveals variants in primary immunodeficiency genes in patients with very early onset inflammatory bowel disease. / 11.2015 / PubMed / Full text
[Effects of soluble egg antigen and adult worm antigen of Schistosoma japonicum on differentiation of effector B cells of mice]. / 10.2013 / PubMed

CDK2

p57 is a master regulator of human adipose derived stem cell quiescence and senescence. / 04.2020 / PubMed / Full text
Induction of Senescence in Cancer Cells by a Novel Combination of Cucurbitacin B and Withanone: Molecular Mechanism and Therapeutic Potential. / 22.05.2020 / PubMed / Full text
Cyclin-Dependent Kinase 2 in Cellular Senescence and Cancer. A Structural and Functional Review. / 2019 / PubMed / Full text
Tenovin-1 Induces Senescence and Decreases Wound-Healing Activity in Cultured Rat Primary Astrocytes. / 01.05.2019 / PubMed / Full text
Relationship between intermuscular adipose tissue infiltration and myostatin before and after aerobic exercise training. / 01.09.2018 / PubMed / Full text
Carvacrol nanoemulsion evokes cell cycle arrest, apoptosis induction and autophagy inhibition in doxorubicin resistant-A549 cell line. / 2018 / PubMed / Full text
Gut flora-dependent metabolite Trimethylamine-N-oxide accelerates endothelial cell senescence and vascular aging through oxidative stress. / 20.02.2018 / PubMed / Full text
Inhibition of CIP2A attenuates tumor progression by inducing cell cycle arrest and promoting cellular senescence in hepatocellular carcinoma. / 08.01.2018 / PubMed / Full text
G protein-coupled receptor kinase 4-induced cellular senescence and its senescence-associated gene expression profiling. / 15.11.2017 / PubMed / Full text
Pneumolysin induces cellular senescence by increasing ROS production and activation of MAPK/NF-κB signal pathway in glial cells. / 04.2017 / PubMed / Full text
The protein-interaction network with functional roles in tumorigenesis, neurodegeneration, and aging. / 12.2016 / PubMed / Full text
A steroid like phytochemical Antcin M is an anti-aging reagent that eliminates hyperglycemia-accelerated premature senescence in dermal fibroblasts by direct activation of Nrf2 and SIRT-1. / 27.09.2016 / PubMed / Full text
Hyaluronan synthase 2 regulates fibroblast senescence in pulmonary fibrosis. / 09.2016 / PubMed / Full text
Double staining of β-galactosidase with fibrosis and cancer markers reveals the chronological appearance of senescence in liver carcinogenesis induced by diethylnitrosamine. / 22.01.2016 / PubMed / Full text
Proton irradiation impacts age-driven modulations of cancer progression influenced by immune system transcriptome modifications from splenic tissue. / 09.2015 / PubMed / Full text
Age and the means of bypassing stasis influence the intrinsic subtype of immortalized human mammary epithelial cells. / 2015 / PubMed / Full text

CDK6

Saturated Fatty Acids Promote Hepatocytic Senecence through Regulation of miR-34a/Cyclin-Dependent Kinase 6. / 24.09.2020 / PubMed / Full text
Hepatoprotective effects of hydroxysafflor yellow A in D-galactose-treated aging mice. / 15.08.2020 / PubMed / Full text
Anti-cell growth and anti-cancer stem cell activity of the CDK4/6 inhibitor palbociclib in breast cancer cells. / 05.2020 / PubMed / Full text
Compromising the constitutive p16 expression sensitizes human neuroblastoma cells to Hsp90 inhibition and promotes premature senescence. / 04.2020 / PubMed / Full text
Palbociclib Effectively Halts Proliferation but Fails to Induce Senescence in Patient-Derived Glioma Stem Cells. / 11.2019 / PubMed / Full text
Avenanthramide A Induces Cellular Senescence via miR-129-3p/Pirh2/p53 Signaling Pathway To Suppress Colon Cancer Growth. / 01.05.2019 / PubMed / Full text
Carvacrol nanoemulsion evokes cell cycle arrest, apoptosis induction and autophagy inhibition in doxorubicin resistant-A549 cell line. / 2018 / PubMed / Full text
Preclinical characterization of abemaciclib in hormone receptor positive breast cancer. / 19.09.2017 / PubMed / Full text
G protein-coupled receptor kinase 4-induced cellular senescence and its senescence-associated gene expression profiling. / 15.11.2017 / PubMed / Full text
Genome-Wide Overexpression Screen Identifies Genes Able to Bypass p16-Mediated Senescence in Melanoma. / 03.2017 / PubMed / Full text
p16INK4a suppresses BRCA1-deficient mammary tumorigenesis. / 20.12.2016 / PubMed / Full text
A steroid like phytochemical Antcin M is an anti-aging reagent that eliminates hyperglycemia-accelerated premature senescence in dermal fibroblasts by direct activation of Nrf2 and SIRT-1. / 27.09.2016 / PubMed / Full text
CDK4-CDK6 inhibitors induce autophagy-mediated degradation of DNMT1 and facilitate the senescence antitumor response. / 02.10.2016 / PubMed / Full text
Sperm-associated antigen 9 (SPAG9) promotes the survival and tumor growth of triple-negative breast cancer cells. / 10.2016 / PubMed / Full text
MicroRNA-33 promotes the replicative senescence of mouse embryonic fibroblasts by suppressing CDK6. / 13.05.2016 / PubMed / Full text
MiR-506 suppresses proliferation and induces senescence by directly targeting the CDK4/6-FOXM1 axis in ovarian cancer. / 07.2014 / PubMed / Full text

CX3CR1

Monocytes present age-related changes in phospholipid concentration and decreased energy metabolism. / 04.2020 / PubMed / Full text
Muscle Injury Induces Postoperative Cognitive Dysfunction. / 17.02.2020 / PubMed / Full text
Dexamethasone Induces a Specific Form of Ramified Dysfunctional Microglia. / 02.2019 / PubMed / Full text
Surgical Trauma Exacerbates Cognitive Deficits and Neuroinflammation in Aged Rats: The Role of CX3CL1-CX3CR1 Signaling. / 01.08.2018 / PubMed / Full text
Repopulating retinal microglia restore endogenous organization and function under CX3CL1-CX3CR1 regulation. / 03.2018 / PubMed / Full text
Cryopreserved whole blood for the quantification of monocyte, T-cell and NK-cell subsets, and monocyte receptor expression by multi-color flow cytometry: A methodological study based on participants from the canadian longitudinal study on aging. / 05.2018 / PubMed / Full text
Microglia and Aging: The Role of the TREM2-DAP12 and CX3CL1-CX3CR1 Axes. / 22.01.2018 / PubMed / Full text
Strain specificities in age-related changes in mechanisms promoting and controlling rat spinal cord damage in experimental autoimmune encephalomyelitis. / 01.2018 / PubMed / Full text
Sex as a determinant of age-related changes in rat spinal cord inflammation-oxidation state. / 10.2017 / PubMed / Full text
Human Monocyte Subsets Are Transcriptionally and Functionally Altered in Aging in Response to Pattern Recognition Receptor Agonists. / 15.08.2017 / PubMed / Full text
Transcriptomic analysis of purified human cortical microglia reveals age-associated changes. / 08.2017 / PubMed / Full text
Phenotypic characteristics of aged CD4 CD28 T lymphocytes are determined by changes in the whole-genome DNA methylation pattern. / 04.2017 / PubMed / Full text
Age exacerbates the CCR2/5-mediated neuroinflammatory response to traumatic brain injury. / 18.04.2016 / PubMed / Full text
Alterations in Monocyte Phenotypes and Functions after a Hip Fracture in Elderly Individuals: A 6-Month Longitudinal Study. / 2016 / PubMed / Full text
Microglia constitute a barrier that prevents neurotoxic protofibrillar Aβ42 hotspots around plaques. / 29.01.2015 / PubMed / Full text
Alterations to the frequency and function of peripheral blood monocytes and associations with chronic disease in the advanced-age, frail elderly. / 2014 / PubMed / Full text

ECD

Outcome of Descemet Membrane Endothelial Keratoplasty Using Corneas from Donors ≥80 Years of Age. / 03.2020 / PubMed / Full text
The occurrence and dynamics of polychlorinated hydrocarbons in roe deer ([i]Capreolus capreolus[/i]) in South-western Slovakia. / 2019 / PubMed / Full text
Corneal thickness, endothelial cell density, and morphological and morphometric features of corneal endothelial cells in goats. / 10.2018 / PubMed / Full text
Endothelial cell density and characterization of corneal endothelial cells in the Tawny Owl (Strix aluco) using specular microscopy. / 03.2019 / PubMed / Full text
An autopsy case report: Differences in radiological images correlate with histology in Erdheim-Chester disease. / 06.2018 / PubMed / Full text
Community-based trials of mobile solutions for the detection and management of cognitive decline. / 06.2017 / PubMed / Full text
Evaluating age-related change in lip somatosensation using somatosensory evoked magnetic fields. / 2017 / PubMed / Full text
A novel method for examining corneal endothelial cell morphology in infants. / 06.2017 / PubMed / Full text
Analyses of Factors Affecting Endothelial Cell Density in an Eye Bank Corneal Donor Database. / 09.2016 / PubMed / Full text
Morphological Abnormalities of Schlemm's Canal in Primary Open-Angle Glaucoma From the Aspect of Aging. / 02.2016 / PubMed / Full text
[TEMPORAL ORDER DETERIORATION AND CIRCADIAN DISRUPTION WITH AGE]. / 2015 / PubMed
Age-Dependent Changes of the Temporal Order--Causes and Treatment. / 2016 / PubMed / Full text
Pathogenesis of endothelial cell dysfunction in chronic kidney disease: a retrospective and what the future may hold. / 06.2015 / PubMed / Full text
Specular microscopy to determine corneal endothelial cell morphology and morphometry in chinchillas (Chinchilla lanigera) in vivo. / 01.2015 / PubMed / Full text
Oncogene-induced senescence as a new mechanism of disease: the paradigm of erdheim-chester disease. / 2014 / PubMed / Full text
Comparison of endothelial cell density of organ cultured corneas with cornea donor study. / 06.2014 / PubMed / Full text

HDAC1

HDAC1 modulates OGG1-initiated oxidative DNA damage repair in the aging brain and Alzheimer's disease. / 18.05.2020 / PubMed / Full text
Loss of genomic integrity induced by lysosphingolipid imbalance drives ageing in the heart. / 04.2019 / PubMed / Full text
Re-exploring the core genes and modules in the human frontal cortex during chronological aging: insights from network-based analysis of transcriptomic studies. / 20.10.2018 / PubMed / Full text
Acetylation of PGC1α by Histone Deacetylase 1 Downregulation Is Implicated in Radiation-Induced Senescence of Brain Endothelial Cells. / 16.05.2019 / PubMed / Full text
Histone deacetylase 1 expression is inversely correlated with age in the short-lived fish Nothobranchius furzeri. / 09.2018 / PubMed / Full text
Ablation of toll-like receptor 4 attenuates aging-induced myocardial remodeling and contractile dysfunction through NCoRI-HDAC1-mediated regulation of autophagy. / 06.2018 / PubMed / Full text
Caloric restriction delays early phases of carcinogenesis via effects on the tissue microenvironment. / 30.05.2017 / PubMed / Full text
Epigallocatechin gallate reverses cTnI-low expression-induced age-related heart diastolic dysfunction through histone acetylation modification. / 10.2017 / PubMed / Full text
Emerging roles for histone deacetylases in age-related muscle atrophy. / 27.10.2016 / PubMed / Full text
[i]Rpd3[/i] interacts with insulin signaling in [i]Drosophila[/i] longevity extension. / 14.11.2016 / PubMed / Full text
Expression of non-secreted IL-4 is associated with HDAC inhibitor-induced cell death, histone acetylation and c-Jun regulation in human gamma/delta T-cells. / 04.10.2016 / PubMed / Full text
The effects of Rpd3 on fly metabolism, health, and longevity. / 15.12.2016 / PubMed / Full text
Parthenolide induces MITF-M downregulation and senescence in patient-derived MITF-M(high) melanoma cell populations. / 23.02.2016 / PubMed / Full text
Scopoletin has a potential activity for anti-aging via autophagy in human lung fibroblasts. / 15.03.2015 / PubMed / Full text
De-regulated expression of the BRG1 chromatin remodeling factor in bone marrow mesenchymal stromal cells induces senescence associated with the silencing of NANOG and changes in the levels of chromatin proteins. / 2015 / PubMed / Full text
Lysine deacetylases regulate the heat shock response including the age-associated impairment of HSF1. / 10.04.2015 / PubMed / Full text

IL10

The beneficial effect of physical exercise on inflammatory makers in older individuals. / 06.06.2020 / PubMed / Full text
Astrocyte senescence may drive alterations in GFAPα, CDKN2A p14 , and TAU3 transcript expression and contribute to cognitive decline. / 10.2019 / PubMed / Full text
Dietary Spray-Dried Porcine Plasma Prevents Cognitive Decline in Senescent Mice and Reduces Neuroinflammation and Oxidative Stress. / 01.02.2020 / PubMed / Full text
Age-dependent hepatic alterations induced by a high-fat high-fructose diet. / 05.2019 / PubMed / Full text
[i]Lactobacillus paracasei[/i] PS23 decelerated age-related muscle loss by ensuring mitochondrial function in SAMP8 mice. / 29.01.2019 / PubMed / Full text
Inflammatory cytokines and immune system modulation by aerobic versus resisted exercise training for elderly. / 03.2018 / PubMed / Full text
Pentoxifylline, dexamethasone and azithromycin demonstrate distinct age-dependent and synergistic inhibition of TLR- and inflammasome-mediated cytokine production in human newborn and adult blood in vitro. / 2018 / PubMed / Full text
Deficiency in Protein Tyrosine Phosphatase PTP1B Shortens Lifespan and Leads to Development of Acute Leukemia. / 01.01.2018 / PubMed / Full text
The role of gender and labour status in immunosenescence of 65 Polish population. / 08.2017 / PubMed / Full text
Serum Immune Mediators Independently Associate with Atherosclerosis in the Left (But Not Right) Carotid Territory of Older Individuals. / 12.2016 / PubMed / Full text
IL10-driven STAT3 signalling in senescent macrophages promotes pathological eye angiogenesis. / 11.08.2015 / PubMed / Full text
Development of depressive symptoms post hip fracture is associated with altered immunosuppressive phenotype in regulatory T and B lymphocytes. / 02.2016 / PubMed / Full text
LIPID PROFILE AND CYTOKINES INTERACTIONS DURING SUCCESSFUL AGING. / 06.2015 / PubMed
The effect of astaxanthin on the aging rat brain: gender-related differences in modulating inflammation. / 30.01.2016 / PubMed / Full text
Candidate SNP associations of optimism and resilience in older adults: exploratory study of 935 community-dwelling adults. / 10.2014 / PubMed / Full text
Oral delivery of glutamic acid decarboxylase (GAD)-65 and IL10 by Lactococcus lactis reverses diabetes in recent-onset NOD mice. / 08.2014 / PubMed / Full text

INS

Melatonin protects INS-1 pancreatic β-cells from apoptosis and senescence induced by glucotoxicity and glucolipotoxicity. / 03.07.2020 / PubMed / Full text
Nicotine triggers islet β cell senescence to facilitate the progression of type 2 diabetes. / 08.2020 / PubMed / Full text
Reducing INS-IGF1 signaling protects against non-cell autonomous vesicle rupture caused by SNCA spreading. / 05.2020 / PubMed / Full text
Insulin-like peptides and the mTOR-TFEB pathway protect [i]Caenorhabditis elegans[/i] hermaphrodites from mating-induced death. / 08.07.2019 / PubMed / Full text
The Maghreb demographic transition: Tunisia case study. / 10-11.2018 / PubMed
Temporal pattern of neuronal insulin release during Caenorhabditis elegans aging: Role of redox homeostasis. / 02.2019 / PubMed / Full text
A functional study of all 40 [i]Caenorhabditis elegans[/i] insulin-like peptides. / 26.10.2018 / PubMed / Full text
The anti-aging protein Klotho is induced by GABA therapy and exerts protective and stimulatory effects on pancreatic beta cells. / 02.12.2017 / PubMed / Full text
Increase of Calcium Sensing Receptor Expression Is Related to Compensatory Insulin Secretion during Aging in Mice. / 2016 / PubMed / Full text
Food-derived sensory cues modulate longevity via distinct neuroendocrine insulin-like peptides. / 01.05.2016 / PubMed / Full text
Resveratrol attenuates senescence of adipose-derived mesenchymal stem cells and restores their paracrine effects on promoting insulin secretion of INS-1 cells through Pim-1. / 2016 / PubMed
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|title=Accommodative movements of the lens/capsule and the strand that extends between the posterior vitreous zonule insertion zone