Публикации о генах и старении (titles)

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A2M

Age-Dependent Variation in Glycosylation Features of Alpha-2-Macroglobulin.


MeSH Terms

  • Adult
  • Aging
  • Electrophoresis, Gel, Two-Dimensional
  • Glycosylation
  • Humans
  • Infant, Newborn
  • Polysaccharides
  • Pregnancy-Associated alpha 2-Macroglobulins
  • Protein Isoforms
  • Umbilical Cord

Keywords

  • Alpha-2-macroglobulin
  • Glycosylation
  • Newborn
  • Plasma

AACS

Sex differences in subjective age-associated changes in sleep: a prospective elderly cohort study.


Keywords

  • aging
  • longitudinal studies
  • normative
  • self-report
  • sex characteristics

ABCG2

Contribution of senescence in human endometrial stromal cells during proliferative phase to embryo receptivity†.


Keywords

  • cellular senescence
  • embryo receptivity
  • endometrial stem cell
  • human endometrial stromal cell
  • infertility


ABCG2 rs2231142 variant in hyperuricemia is modified by SLC2A9 and SLC22A12 polymorphisms and cardiovascular risk factors in an elderly community-dwelling population.


MeSH Terms

  • ATP Binding Cassette Transporter, Subfamily G, Member 2
  • Aged
  • Aged, 80 and over
  • Aging
  • Cardiovascular Diseases
  • China
  • Cohort Studies
  • Effect Modifier, Epidemiologic
  • Epistasis, Genetic
  • Female
  • Genes, Modifier
  • Genetic Predisposition to Disease
  • Genome-Wide Association Study
  • Glucose Transport Proteins, Facilitative
  • Humans
  • Hyperuricemia
  • Independent Living
  • Male
  • Neoplasm Proteins
  • Organic Anion Transporters
  • Organic Cation Transport Proteins
  • Polymorphism, Single Nucleotide
  • Risk Factors
  • Uric Acid

Keywords

  • ABCG2
  • Hypertension
  • Polymorphisms
  • Triglyceridemia
  • Uric acid

ABL1

European LeukemiaNet 2020 recommendations for treating chronic myeloid leukemia.


MeSH Terms

  • Aniline Compounds
  • Antineoplastic Agents
  • Clinical Decision-Making
  • Consensus Development Conferences as Topic
  • Dasatinib
  • Disease Management
  • Fusion Proteins, bcr-abl
  • Gene Expression
  • Humans
  • Imatinib Mesylate
  • Leukemia, Myelogenous, Chronic, BCR-ABL Positive
  • Life Expectancy
  • Monitoring, Physiologic
  • Nitriles
  • Protein Kinase Inhibitors
  • Pyrimidines
  • Quality of Life
  • Quinolines
  • Survival Analysis

ABO

Allelic distribution of [i]ABO[/i] gene in Chinese centenarians.


Keywords

  • ABO gene
  • centenarian
  • longevity
  • single nucleotide polymorphisms


Genetically Determined ABO Blood Group and its Associations With Health and Disease.


MeSH Terms

  • ABO Blood-Group System
  • Adult
  • Age Factors
  • Aged
  • Cardiovascular Diseases
  • Female
  • Gene Frequency
  • Genetic Predisposition to Disease
  • Health Status
  • Healthy Aging
  • Humans
  • Incidence
  • Male
  • Middle Aged
  • Phenotype
  • Polymorphism, Single Nucleotide
  • Prevalence
  • Risk Assessment
  • Risk Factors
  • United Kingdom

Keywords

  • ABO
  • aging
  • blood
  • genetics
  • hypertension
  • phenotype

ABR

[Hidden hearing loss and early identification].


MeSH Terms

  • Acoustic Stimulation
  • Audiometry, Pure-Tone
  • Auditory Threshold
  • Evoked Potentials, Auditory, Brain Stem
  • Hearing Loss, Noise-Induced
  • Humans
  • Noise

Keywords

  • aging
  • drug damage
  • hidden hearing loss
  • noise exposure


Aging But Not Age-Related Hearing Loss Dominates the Decrease of Parvalbumin Immunoreactivity in the Primary Auditory Cortex of Mice.


Keywords

  • age-related hearing loss
  • aging
  • mouse primary auditoy cortex
  • parvalbumin


Hearing loss through apoptosis of the spiral ganglion neurons in apolipoprotein E knockout mice fed with a western diet.


MeSH Terms

  • Aging
  • Animals
  • Apolipoproteins E
  • Apoptosis
  • Diet, Western
  • Disease Models, Animal
  • Hearing Loss
  • Male
  • Mice
  • Mice, Inbred C57BL
  • Mice, Knockout
  • Neurons
  • Spiral Ganglion

Keywords

  • Apoptosis
  • Atherosclerosis
  • Hearing loss
  • Reactive oxygen specie
  • Spiral ganglion neurons


Effects of enriched endogenous omega-3 fatty acids on age-related hearing loss in mice.


MeSH Terms

  • Aging
  • Animals
  • Body Weight
  • Caenorhabditis elegans Proteins
  • Cochlea
  • Evoked Potentials, Auditory, Brain Stem
  • Fatty Acid Desaturases
  • Fatty Acids, Omega-3
  • Male
  • Mice
  • Mice, Inbred C57BL
  • Mice, Transgenic
  • Neurons
  • Presbycusis
  • Spiral Ganglion

Keywords

  • Age-related hearing loss
  • C57BL/6 mouse
  • Cochlea
  • Omega-3 (n-3) fatty acids


Hearing impairment and associated morphological changes in pituitary adenylate cyclase activating polypeptide (PACAP)-deficient mice.


MeSH Terms

  • Aging
  • Animals
  • Cochlea
  • Evoked Potentials, Auditory, Brain Stem
  • Genotype
  • Hearing
  • Hearing Loss
  • Inflammation
  • Male
  • Mice
  • Mice, Knockout
  • Models, Animal
  • Neovascularization, Pathologic
  • Neurons
  • Pituitary Adenylate Cyclase-Activating Polypeptide
  • Proteome
  • Proto-Oncogene Proteins c-fos


Global nurse/midwife workforce and reproductive health through social ecology lens.


MeSH Terms

  • Adolescent
  • Cross-Sectional Studies
  • Employment
  • Female
  • Global Health
  • Health Education
  • Humans
  • Income
  • Life Expectancy
  • Male
  • Midwifery
  • Pregnancy
  • Reproductive Health
  • Social Environment
  • Socioeconomic Factors
  • Workforce

Keywords

  • global health
  • nurse/midwife workforce
  • reproductive health
  • social ecology

ACD

Genetics of cognitive trajectory in Brazilians: 15 years of follow-up from the Bambuí-Epigen Cohort Study of Aging.


MeSH Terms

  • Age Factors
  • Aged
  • Aging
  • Brazil
  • Cognition
  • Cognitive Dysfunction
  • Cohort Studies
  • Female
  • Follow-Up Studies
  • Genetic Predisposition to Disease
  • Genome-Wide Association Study
  • Humans
  • Male
  • Middle Aged
  • Polymorphism, Single Nucleotide

ACE

Elite swimmers possess shorter telomeres than recreationally active controls.


Keywords

  • Aging
  • Athlete
  • Exercise
  • Genetics


Coronavirus Disease-2019 Conundrum: RAS Blockade and Geriatric-Associated Neuropsychiatric Disorders.


Keywords

  • ACE2
  • ACEIs
  • ARBs
  • COVID-19
  • RAS
  • SARS-CoV-2
  • geriatrics
  • neuropsychiatric disorders


Pregnancy Protects Hyperandrogenemic Female Rats From Postmenopausal Hypertension.


Keywords

  • aging
  • endothelin
  • menopause
  • nitric oxide
  • renin-angiotensin system


Heart failure is associated with accelerated age related metabolic bone disease.


Keywords

  • Heart failure
  • comorbidities
  • geriatrics
  • metabolic bone disease
  • osteoporosis


Management of heart failure: an Italian national survey on fellows/specialists in geriatrics.


MeSH Terms

  • Aged
  • Geriatrics
  • Heart Failure
  • Humans
  • Italy
  • Specialization
  • Stroke Volume
  • Surveys and Questionnaires

Keywords

  • Aged, 65 years or over
  • Care survey
  • Health
  • Heart failure


Angiotensin-Converting Enzyme (ACE) genetic variation and longevity in Peruvian older people: a cross-sectional study.


MeSH Terms

  • Aged
  • Aged, 80 and over
  • Cross-Sectional Studies
  • Female
  • Genetic Variation
  • Humans
  • Longevity
  • Male
  • Middle Aged
  • Peptidyl-Dipeptidase A
  • Peru
  • Polymorphism, Genetic

Keywords

  • ACE gene
  • Longevity
  • Perú
  • ageing


COVID-19 and chronological aging: senolytics and other anti-aging drugs for the treatment or prevention of corona virus infection?


MeSH Terms

  • Age Factors
  • Aged
  • Aged, 80 and over
  • Aging
  • Angiotensin-Converting Enzyme 2
  • Antiviral Agents
  • Azithromycin
  • Betacoronavirus
  • COVID-19
  • Coronavirus Infections
  • Dipeptidyl Peptidase 4
  • Humans
  • Hydroxychloroquine
  • Pandemics
  • Peptidyl-Dipeptidase A
  • Pneumonia, Viral
  • Quercetin
  • Receptors, Virus
  • SARS-CoV-2

Keywords

  • Azithromycin
  • COVID-19
  • Doxycycline
  • Hydroxy-chloroquine
  • Quercetin
  • Rapamycin
  • aging
  • antibiotic
  • corona virus
  • drug repurposing
  • prevention
  • senescence
  • senolytic drug therapy
  • viral replication


[i]A[/i]ngiotensin Converting Enzyme Inhibitors [i]C[/i]ombined with [i]E[/i]xercise for Hypertensive [i]S[/i]eniors (The ACES Trial): Study Protocol of a Randomized Controlled Trial.


Keywords

  • aging
  • antihypertensive
  • exercise
  • functional status
  • hypertension


Vascular age.


MeSH Terms

  • Adolescent
  • Adult
  • Aged
  • Aging
  • Angiotensin-Converting Enzyme Inhibitors
  • Atherosclerosis
  • Child
  • Elasticity
  • Humans
  • Middle Aged
  • Perindopril
  • Pulse Wave Analysis
  • Vascular Stiffness
  • Young Adult

Keywords

  • ACE inhibitors
  • CT angiography
  • atorvastatin
  • dyslipidemia
  • hypertension
  • intima media thickness (IMT)
  • perindopril
  • pulse wave velocity (PWV)
  • statins
  • vascular age

ACE2

How Does SARS-CoV-2 Affect the Central Nervous System? A Working Hypothesis.


Keywords

  • ACE2
  • Alzheimer disease
  • Ang(1-7)/Mas
  • COVID-19
  • RAAS
  • SARS-CoV
  • brain aging
  • neurodegenerative and psychiatric disorders abstract


Bioinformatic characterization of angiotensin-converting enzyme 2, the entry receptor for SARS-CoV-2.


MeSH Terms

  • Aging
  • Angiotensin-Converting Enzyme 2
  • Betacoronavirus
  • Binding Sites
  • COVID-19
  • Carrier Proteins
  • Computational Biology
  • Coronavirus Infections
  • Female
  • Gene Expression Regulation, Enzymologic
  • Gene Ontology
  • Humans
  • Interferons
  • Lung
  • Male
  • Metalloproteases
  • Neovascularization, Physiologic
  • Organ Specificity
  • Pandemics
  • Peptidyl-Dipeptidase A
  • Pneumonia, Viral
  • Promoter Regions, Genetic
  • RNA, Messenger
  • Receptors, Virus
  • Renin-Angiotensin System
  • SARS-CoV-2
  • Sex Characteristics
  • Single-Cell Analysis
  • Transcription Factors
  • Transcription Initiation Site
  • Virus Attachment


A mouse-adapted model of SARS-CoV-2 to test COVID-19 countermeasures.


MeSH Terms

  • Aging
  • Angiotensin-Converting Enzyme 2
  • Animals
  • Betacoronavirus
  • COVID-19
  • COVID-19 Vaccines
  • Coronavirus Infections
  • Disease Models, Animal
  • Female
  • Forkhead Transcription Factors
  • Humans
  • Interferon-alpha
  • Interferons
  • Interleukins
  • Male
  • Mice
  • Mice, Inbred BALB C
  • Mice, Transgenic
  • Models, Molecular
  • Pandemics
  • Peptidyl-Dipeptidase A
  • Pneumonia, Viral
  • Receptors, Virus
  • SARS-CoV-2
  • Viral Vaccines


COVID-19 and Senotherapeutics: Any Role for the Naturally-occurring Dipeptide Carnosine?


Keywords

  • acetyl-carnosine
  • aging
  • carnosine
  • inflammation
  • lungs
  • olfaction
  • virus


The dual impact of ACE2 in COVID-19 and ironical actions in geriatrics and pediatrics with possible therapeutic solutions.


MeSH Terms

  • Age Factors
  • Aged
  • Aged, 80 and over
  • Angiotensin-Converting Enzyme 2
  • Anti-Inflammatory Agents
  • Betacoronavirus
  • COVID-19
  • Child
  • Child, Preschool
  • Coronavirus
  • Coronavirus Infections
  • Female
  • Geriatrics
  • Humans
  • Infant
  • Infant, Newborn
  • Male
  • Pandemics
  • Pediatrics
  • Peptidyl-Dipeptidase A
  • Pneumonia, Viral
  • Protein Binding
  • Receptors, Virus
  • Renin-Angiotensin System
  • SARS-CoV-2
  • Severe Acute Respiratory Syndrome
  • Virus Internalization

Keywords

  • ACE2
  • Angiotensin 2
  • Angiotensin-(1–7)
  • Corona virus
  • Glycoprotein spikes
  • RAAS system


The possible pathophysiology mechanism of cytokine storm in elderly adults with COVID-19 infection: the contribution of "inflame-aging".


MeSH Terms

  • Adipocytes
  • Age Factors
  • Aged
  • Aging
  • Angiotensin II Type 2 Receptor Blockers
  • Autophagy
  • Betacoronavirus
  • COVID-19
  • Cellular Senescence
  • Coronavirus Infections
  • Cytokine Release Syndrome
  • Cytokines
  • Humans
  • Immune System
  • Inflammation
  • Pandemics
  • Pneumonia, Viral
  • Reactive Oxygen Species
  • Receptor, Angiotensin, Type 2
  • SARS-CoV-2
  • Vitamin D
  • Vitamin D Deficiency

Keywords

  • ACE2 receptor
  • Autophagy
  • COVID-19
  • Cytokine storm
  • Senescent cell
  • Vitamin D


Decoding SARS-CoV-2 hijacking of host mitochondria in COVID-19 pathogenesis.


MeSH Terms

  • Adaptive Immunity
  • Angiotensin-Converting Enzyme 2
  • Animals
  • Betacoronavirus
  • COVID-19
  • Coronavirus Infections
  • DNA, Mitochondrial
  • Gene Expression Regulation, Viral
  • Host Microbial Interactions
  • Humans
  • Immunity, Innate
  • Mitochondria
  • Pandemics
  • Peptidyl-Dipeptidase A
  • Pneumonia, Viral
  • RNA, Viral
  • SARS-CoV-2
  • Virus Replication

Keywords

  • COVID-19
  • SARS-CoV
  • aging
  • coronavirus
  • mitochondria
  • mitochondrial DNA


A Mouse Model of SARS-CoV-2 Infection and Pathogenesis.


MeSH Terms

  • Aging
  • Angiotensin-Converting Enzyme 2
  • Animals
  • Betacoronavirus
  • Brain
  • COVID-19
  • CRISPR-Cas Systems
  • Coronavirus Infections
  • Cytokines
  • Disease Models, Animal
  • Gene Knock-In Techniques
  • Lung
  • Lung Diseases, Interstitial
  • Mice, Inbred C57BL
  • Nose
  • Pandemics
  • Peptidyl-Dipeptidase A
  • Pneumonia, Viral
  • RNA, Viral
  • SARS-CoV-2
  • Stomach
  • Trachea
  • Viral Load
  • Virus Replication

Keywords

  • SARS-CoV-2
  • angiotensin-converting enzyme II
  • hACE2-KI/NIFDC
  • mouse model
  • pathogenesis


COVID-19-associated cardiovascular morbidity in older adults: a position paper from the Italian Society of Cardiovascular Researches.


MeSH Terms

  • Age Factors
  • Aged
  • Betacoronavirus
  • COVID-19
  • Cardiovascular Diseases
  • Coronavirus Infections
  • Female
  • Humans
  • Italy
  • Male
  • Middle Aged
  • Pandemics
  • Pneumonia, Viral
  • Risk Factors
  • SARS-CoV-2

Keywords

  • Acute myocardial injury
  • Aging
  • COVID-19
  • Cardiovascular system
  • Frailty
  • SARS-CoV-2


Gut microbiota and Covid-19- possible link and implications.


MeSH Terms

  • Aging
  • Betacoronavirus
  • COVID-19
  • Coronavirus Infections
  • Diet
  • Dysbiosis
  • Gastrointestinal Microbiome
  • Gastrointestinal Tract
  • Homeostasis
  • Humans
  • Immunity
  • Lung
  • Pandemics
  • Pneumonia, Viral
  • SARS-CoV-2

Keywords

  • Covid-19
  • Diet
  • Dysbiosis
  • Gut microbiome
  • Immunity
  • Lung microbiota
  • SARS-CoV-2


Inflamm-aging: Why older men are the most susceptible to SARS-CoV-2 complicated outcomes.


MeSH Terms

  • Aged
  • Aged, 80 and over
  • Aging
  • Angiotensin-Converting Enzyme 2
  • Antibodies, Monoclonal, Humanized
  • Betacoronavirus
  • COVID-19
  • Comorbidity
  • Coronavirus Infections
  • Female
  • Humans
  • Inflammation
  • Interferon Type I
  • Interleukin-6
  • Male
  • Pandemics
  • Peptidyl-Dipeptidase A
  • Pneumonia, Viral
  • SARS-CoV-2
  • Severe Acute Respiratory Syndrome

Keywords

  • COVID-19
  • Cardiovascular diseases
  • Host-directed therapies
  • Inflamm-aging
  • SARS-CoV-2
  • interleukin-6


Restoration of the Renin-Angiotensin System Balance Is a Part of the Effect of Fasting on Cardiovascular Rejuvenation: Role of Age and Fasting Models.


Keywords

  • aging
  • cardiac hypertrophy index
  • intermittent fasting
  • renin–angiotensin system (RAS)


Angiotensin 1-7 alleviates aging-associated muscle weakness and bone loss, but is not associated with accelerated aging in ACE2-knockout mice.


MeSH Terms

  • Adipose Tissue
  • Aging
  • Angiotensin I
  • Angiotensin-Converting Enzyme 2
  • Animals
  • Body Weight
  • Bone Resorption
  • Cyclin-Dependent Kinase Inhibitor p16
  • Forelimb
  • Gene Deletion
  • Hand Strength
  • Male
  • Mice, Inbred C57BL
  • Mice, Knockout
  • Muscle Weakness
  • Muscles
  • Organ Size
  • PAX3 Transcription Factor
  • Peptide Fragments
  • Peptidyl-Dipeptidase A
  • Proto-Oncogene Proteins
  • Receptors, G-Protein-Coupled
  • Renin-Angiotensin System
  • Time Factors

Keywords

  • Angiotensin 1-7
  • Angiotensin Converting Enzyme 2
  • Mas receptor
  • Muscle weakness
  • osteoporosis

ACLY

In S. cerevisiae hydroxycitric acid antagonizes chronological aging and apoptosis regardless of citrate lyase.


Keywords

  • Aging
  • Apoptosis/necrosis
  • Caloric restriction mimetics
  • Hydroxycitric acid
  • Oxidative stress
  • Sch9 and Ras2 pathways

ACR

Progenitor cell niche senescence reflects pathology of the parotid salivary gland in primary Sjögren's syndrome.


Keywords

  • p16
  • primary Sjögren’s syndrome
  • salivary gland
  • salivary gland progenitor cells
  • senescence


Jumping Joints: The Complex Relationship Between Osteoarthritis and Jumping Mechanography.


Keywords

  • Aging
  • Jumping mechanography
  • Muscle
  • Osteoarthritis
  • Sarcopenia

ACVR1

Fibrodysplasia Ossificans Progressiva (FOP): A Segmental Progeroid Syndrome.


Keywords

  • ACVR1
  • activin A
  • cell senescence
  • fibrodysplasia ossificans progressiva
  • progeroid syndrome

ADA

Adenosine Metabolism in the Cerebral Cortex from Several Mice Models during Aging.


Keywords

  • adenosine metabolism
  • aging
  • animal models
  • glutamate
  • purinergic signaling

ADAM10

NKG2D Ligand Shedding in Response to Stress: Role of ADAM10.


Keywords

  • ADAM10
  • NKG2D
  • NKG2D ligands
  • cancer
  • chemotherapy
  • senescence
  • shedding


Chronic Mild Stress Modified Epigenetic Mechanisms Leading to Accelerated Senescence and Impaired Cognitive Performance in Mice.


MeSH Terms

  • ADAM10 Protein
  • Aging
  • Amyloid Precursor Protein Secretases
  • Animals
  • Cognition
  • Epigenesis, Genetic
  • Female
  • Glial Fibrillary Acidic Protein
  • Glycogen Synthase Kinase 3 beta
  • Mechanistic Target of Rapamycin Complex 1
  • Membrane Proteins
  • Mice
  • MicroRNAs
  • NF-kappa B
  • Reactive Oxygen Species
  • Signal Transduction
  • Stress, Psychological

Keywords

  • Alzheimer’s disease
  • SAMP8
  • SAMR1
  • age-related cognitive decline
  • autophagy
  • cognition
  • epigenetics
  • inflammation
  • oxidative stress
  • senescence
  • stress

ADAM17

ACE2/ADAM17/TMPRSS2 Interplay May Be the Main Risk Factor for COVID-19.


MeSH Terms

  • ADAM17 Protein
  • Aged
  • Aging
  • Angiotensin-Converting Enzyme 2
  • Betacoronavirus
  • COVID-19
  • Comorbidity
  • Coronavirus Infections
  • Female
  • Humans
  • Male
  • Pandemics
  • Peptidyl-Dipeptidase A
  • Pneumonia, Viral
  • Receptors, Interleukin-6
  • Risk Factors
  • SARS-CoV-2
  • Serine Endopeptidases
  • Tumor Necrosis Factor-alpha

Keywords

  • ACE2
  • ADAM17
  • COVID-19 pathophysiology
  • SARS-CoV-2
  • TMPRSS2

ADH5

Can Serum Nitrosoproteome Predict Longevity of Aged Women?


Keywords

  • aging
  • cardiovascular disease
  • muscle atrophy
  • nitrosative stress
  • proteomics

ADM

Assessment of age-related differences in decomposition-based quantitative EMG in the intrinsic hand muscles: A multivariate approach.


Keywords

  • Aging
  • Decomposition-based quantitative electromyography (DQEMG)
  • Hand muscle
  • Jiggle
  • Motor unit potential (MUP)
  • Multivariate


Evaluation of transcriptional levels of the natriuretic peptides, endothelin-1, adrenomedullin, their receptors and long non-coding RNAs in rat cardiac tissue as cardiovascular biomarkers of aging.


Keywords

  • ADM system
  • Aging
  • Biomarkers
  • ET-1system
  • LncRNA
  • NP system

ADORA2B

Adenosine A2B receptor: A pathogenic factor and a therapeutic target for sensorineural hearing loss.


Keywords

  • ADA-deficiency
  • adenosine deaminase deficiency
  • aging
  • myelin protein zero
  • myelination

ADRA2A

α2A-Adrenergic Receptor Inhibits the Progression of Cervical Cancer Through Blocking PI3K/AKT/mTOR Pathway.


Keywords

  • ADRA2A
  • PI3K/Akt/mTOR pathway
  • cervical cancer
  • metastasis
  • proliferation
  • senescence

AFM

Photocatalytic aging process of Nano-TiO coated polypropylene microplastics: Combining atomic force microscopy and infrared spectroscopy (AFM-IR) for nanoscale chemical characterization.


Keywords

  • AFM-IR
  • Aging process
  • Microplastics
  • Nanoscale characterization
  • Polypropylene


Nanoscale infrared, thermal and mechanical properties of aged microplastics revealed by an atomic force microscopy coupled with infrared spectroscopy (AFM-IR) technique.


Keywords

  • AFM-IR
  • Aging process
  • Mechanical properties
  • Microplastics (MPs)
  • Thermal analysis


Detecting zeta potential of polydimethylsiloxane (PDMS) in electrolyte solutions with atomic force microscope.


Keywords

  • AFM
  • Air plasma treatment
  • Liquid aging
  • PDMS
  • Zeta potential


Recent Applications of Advanced Atomic Force Microscopy in Polymer Science: A Review.


Keywords

  • AFM-IR
  • blends
  • nanoscale characterization
  • polymer aging
  • polymer composites
  • polymers


Active fractions of mannoproteins derived from yeast cell wall stimulate innate and acquired immunity of adult and elderly dogs.


Keywords

  • AFM, active fraction of mannoproteins
  • ALP, alkaline phosphatase
  • ALT, alanine aminotransferase
  • Ageing
  • CBC, complete blood count
  • CD21+, B lymphocyte
  • CD4+, auxiliary T lymphocyte
  • CD5+, total T lymphocyte
  • CD8+, cytotoxic lymphocyte
  • CO, cells only
  • Canine
  • DCHT, delayed cutaneous hypersensitivity test
  • FOSs, fructooligosaccharides
  • GALT, gut-associated lymphoid tissue
  • IL-12, interleukin 12
  • IgA, immunoglobulin A
  • Immunosenescence
  • LPS, bacterial lipopolysaccharide
  • MOSs, mannanoligosaccharides
  • NADPH, reduced nicotinamide adenine dinucleotide phosphate
  • NO, nitrogen monoxide
  • NOS, nitric oxide synthase
  • OD, optical density
  • PMA, phorbol myristate acetate
  • Saccharomyces cerevisiae
  • Senescence
  • TNF-α, tumour necrosis factor alpha
  • Th1, helper T lymphocyte


The Effect of Waste Engine Oil and Waste Polyethylene on UV Aging Resistance of Asphalt.


Keywords

  • Fourier transform infrared spectroscopy
  • atomic force microscopy
  • gel permeation chromatography
  • ultraviolet aging
  • waste engine oil
  • waste polyethylene


Mechanical properties measured by atomic force microscopy define health biomarkers in ageing C. elegans.


MeSH Terms

  • Aging
  • Animal Feed
  • Animals
  • Bacillus subtilis
  • Biomarkers
  • Caenorhabditis elegans
  • Caenorhabditis elegans Proteins
  • Comamonas
  • Escherichia coli
  • Forkhead Transcription Factors
  • Hot Temperature
  • Insulin
  • Microbiota
  • Microscopy, Atomic Force
  • Mutation
  • Receptor, Insulin
  • Signal Transduction
  • Ultraviolet Rays


Nanomechanical insights: Amyloid beta oligomer-induced senescent brain endothelial cells.


MeSH Terms

  • Alzheimer Disease
  • Amyloid beta-Peptides
  • Biomechanical Phenomena
  • Brain
  • Cell Culture Techniques
  • Cell Membrane
  • Cellular Senescence
  • Endothelial Cells
  • Endothelium, Vascular
  • Humans
  • Microscopy, Atomic Force
  • Vascular Endothelial Growth Factor A

Keywords

  • Amyloid beta oligomer
  • Atomic force microscopy
  • Brain endothelial cells
  • Nanoindentation
  • Nanomechanical properties
  • Senescence

AGER

Vitamin D3 regulates apoptosis and proliferation in the testis of D-galactose-induced aged rat model.


MeSH Terms

  • Aging
  • Animals
  • Antioxidants
  • Apoptosis
  • Cell Proliferation
  • Cholecalciferol
  • Down-Regulation
  • Galactose
  • Male
  • Oxidative Stress
  • Rats
  • Spermatogenesis
  • Testis

AGT

SQSTM1/p62 and PPARGC1A/PGC-1alpha at the interface of autophagy and vascular senescence.


Keywords

  • Aging
  • SQSTM1
  • autophagy
  • oxidative stress
  • senescence
  • vascular biology

AHR

Indoles from the commensal microbiota act via the AHR and IL-10 to tune the cellular composition of the colonic epithelium during aging.


MeSH Terms

  • Aging
  • Animals
  • Bacteria
  • Cell Differentiation
  • Epithelial Cells
  • Female
  • Goblet Cells
  • Indoles
  • Interleukin-10
  • Interleukins
  • Male
  • Mice
  • Mice, Inbred BALB C
  • Mice, Inbred C57BL
  • Mice, Knockout
  • Microbiota
  • Mucus
  • Receptors, Aryl Hydrocarbon
  • Signal Transduction

Keywords

  • aging
  • goblet cell
  • intestinal homeostasis
  • mucus


Role of the Aryl Hydrocarbon Receptor in Environmentally Induced Skin Aging and Skin Carcinogenesis.


MeSH Terms

  • Animals
  • Environmental Exposure
  • Extracellular Matrix
  • Humans
  • Receptors, Aryl Hydrocarbon
  • Skin Aging
  • Skin Neoplasms

Keywords

  • DNA damage
  • UV radiation
  • extracellular matrix
  • extrinsic skin aging
  • melanoma
  • particulate matter
  • pigmentation
  • polycyclic aromatic hydrocarbons
  • squamous cell carcinoma

AIP

[Aryl hydrocarbon receptor interacting protein (AIP) in human dermis during aging.]


Keywords

  • AIP
  • PCNA
  • aging
  • fibroblasts
  • skin


Sex-Specific Association between Serum Vitamin D Status and Lipid Profiles: A Cross-Sectional Study of a Middle-Aged and Elderly Chinese Population.


Keywords

  • atherogenic index of plasma
  • dyslipidaemia
  • gerontology
  • sex difference
  • vitamin D


The oblique effect: The relationship between profiles of visuospatial preference, cognition, and brain connectomics in older adults.


MeSH Terms

  • Aged
  • Brain
  • Cognition
  • Connectome
  • Diffusion Tensor Imaging
  • Executive Function
  • Female
  • Humans
  • Judgment
  • Male
  • Middle Aged
  • Neuropsychological Tests
  • Pattern Recognition, Visual
  • Spatial Processing

Keywords

  • Aging
  • Executive function
  • Oblique effect
  • Perception
  • Structural connectivity
  • Visuospatial processing

ALAS1

Heterozygous disruption of ALAS1 in mice causes an accelerated age-dependent reduction in free heme, but not total heme, in skeletal muscle and liver.


Keywords

  • 5-Aminolevulinate synthase 1 (ALAS1)
  • 5-Aminolevulinic acid (ALA)
  • Aging
  • Free heme
  • Liver
  • Skeletal muscle

ALB

Effects of Age on Inflammatory Profiles and Nutrition/Energy Metabolism in Domestic Cats.


Keywords

  • M/L ratio
  • SAA
  • aging
  • domestic cats
  • obesity

ALK

Catalog of Lung Cancer Gene Mutations Among Chinese Patients.


Keywords

  • China
  • aging
  • gene mutation
  • lung cancer
  • pathology
  • tobacco smoking

ALKBH8

Loss of epitranscriptomic control of selenocysteine utilization engages senescence and mitochondrial reprogramming .


MeSH Terms

  • AlkB Homolog 8, tRNA Methyltransferase
  • Animals
  • Cells, Cultured
  • Cellular Senescence
  • Epigenesis, Genetic
  • Gene Deletion
  • Gene Expression Profiling
  • Humans
  • Mice
  • Mitochondria
  • Oxygen Consumption
  • Selenocysteine
  • Uncoupling Protein 2

Keywords

  • Epitranscriptome
  • Mitochondria
  • Selenium
  • Senescence
  • Uncoupling protein

ALOX12

Arachidonate 12-lipoxygenase and 12-hydroxyeicosatetraenoic acid contribute to stromal aging-induced progression of pancreatic cancer.


Keywords

  • aging
  • arachidonic acid (AA) (ARA)
  • cancer biology
  • cell proliferation
  • fibroblast
  • pancreatic cancer
  • stromal cell

ALOX5

Functional Characterization of Knock-In Mice Expressing a 12/15-Lipoxygenating Alox5 Mutant Instead of the 5-Lipoxygenating Wild-Type Enzyme.


MeSH Terms

  • Aging
  • Alanine
  • Animals
  • Arachidonate 5-Lipoxygenase
  • Asparagine
  • Body Weight
  • Female
  • Gene Knock-In Techniques
  • Leukotrienes
  • Linoleic Acid
  • Male
  • Mice
  • Mutation
  • PPAR gamma
  • Phenylalanine

Keywords

  • eicosanoids
  • inflammation
  • leukotrienes
  • lipoxygenase
  • resolvins

AMH

Beyond premature ovarian insufficiency: Staging reproductive aging in adolescent and young adult cancer survivors.


Keywords

  • STRAW
  • adolescent and young adult cancer
  • menopausal transition
  • premature ovarian insufficiency
  • reproductive aging


Correlates and Timing of Reproductive Aging Transitions in a Global Cohort of Midlife Women With Human Immunodeficiency Virus: Insights From the REPRIEVE Trial.


Keywords

  • Cardiometabolic Risk
  • HIV
  • Menopause
  • Reproductive Aging
  • Sex
  • Women


Epigenetic clock measuring age acceleration via DNA methylation levels in blood is associated with decreased oocyte yield.


Keywords

  • Aging
  • DNA methylation
  • Epigenetic clock
  • Epigenetics
  • Infertility
  • Methylome
  • Ovarian aging


Modeling Variation in the Reproductive Lifespan of Female Adolescent and Young Adult Cancer Survivors Using AMH.


Keywords

  • AMH
  • adolescent and young adult cancer
  • functional principal components analysis
  • ovarian reserve
  • reproductive lifespan


Improving Prediction of Age at Menopause Using Multiple Anti-Müllerian Hormone Measurements: the Tehran Lipid-Glucose Study.


Keywords

  • Tehran Lipid and Glucose Study (TLGS)
  • anti-müllerian hormone (AMH)
  • menopause
  • reproductive aging


Antimullerian Hormone and Impending Menopause in Late Reproductive Age: The Study of Women's Health Across the Nation.


Keywords

  • aging
  • female reproductive endocrinology
  • gonadotropins
  • inhibin/activin/follistatin/AMH
  • menopause
  • ovaries


Basal characterization and in vitro differentiation of putative stem cells derived from the adult mouse ovary.


MeSH Terms

  • Aging
  • Animals
  • Anti-Mullerian Hormone
  • Antigens, Ly
  • Cell Differentiation
  • Cell Shape
  • Female
  • Lewis X Antigen
  • Membrane Proteins
  • Mice, Inbred C57BL
  • Ovary
  • Stem Cells

Keywords

  • BMP-4
  • Multipotent
  • Ovary
  • Retinoic acid
  • Stem cells


Serum anti-Müllerian hormone concentration and follicle density throughout reproductive life and in different diseases-implications in fertility preservation.


MeSH Terms

  • Adolescent
  • Adult
  • Aging
  • Anti-Mullerian Hormone
  • Child
  • Child, Preschool
  • Female
  • Fertility Preservation
  • Humans
  • Ovarian Follicle
  • Retrospective Studies
  • Young Adult

Keywords

  • anti-Müllerian hormone
  • cancer
  • fertility preservation
  • ovarian reserve
  • ovarian tissue
  • primary follicle
  • primordial follicle


Associations Between Anti-Mullerian Hormone and Cardiometabolic Health in Reproductive Age Women Are Explained by Body Mass Index.


MeSH Terms

  • Adult
  • Anti-Mullerian Hormone
  • Biomarkers
  • Body Mass Index
  • Cardiovascular Diseases
  • Case-Control Studies
  • Cross-Sectional Studies
  • Female
  • Follow-Up Studies
  • Humans
  • Incidence
  • Infertility, Female
  • Polycystic Ovary Syndrome
  • Prognosis
  • United States

Keywords

  • anti-mullerian hormone (AMH)
  • cardiometabolic health
  • cardiovascular risk
  • ovarian aging
  • ovarian reserve markers
  • reproductive aging


Relationships between antral follicle count, blood serum concentration of anti-Müllerian hormone and fertility in mares.


MeSH Terms

  • Aging
  • Animals
  • Anti-Mullerian Hormone
  • Female
  • Fertility
  • Horses
  • Ovarian Follicle
  • Ovulation

Keywords

  • AMH
  • Anzahl Follikel
  • Ovar
  • Pferd
  • Ultraschall
  • compte folliculaire
  • conta dei follicoli
  • ecografia
  • equine
  • equini
  • follicle count
  • ovaia
  • ovaire
  • ovary
  • reproductive status
  • stato riproduttivo
  • ultrasonography
  • ­Reproduktionsstatus
  • échographie
  • équin
  • état reproducteur

AMT

A multi-method comparison of autobiographical memory impairments amongst younger and older adults.


Keywords

  • Depression
  • aging
  • episodic memory
  • overgeneral
  • specificity

ANGPTL2

Circulating angiopoietin-like protein 2 levels and mortality risk in patients receiving maintenance hemodialysis: a prospective cohort study.


MeSH Terms

  • Aged
  • Angiopoietin-like Proteins
  • Biomarkers
  • C-Reactive Protein
  • Disease Progression
  • Female
  • Humans
  • Kidney Diseases
  • Male
  • Middle Aged
  • Prognosis
  • Prospective Studies
  • Renal Dialysis
  • Risk Factors
  • Survival Rate

Keywords

  • aging
  • angiopoietin-like protein (ANGPTL) 2
  • chronic inflammation
  • hemodialysis
  • mortality risk

ANK3

Age-related atrophy of cortical thickness and genetic effect of ANK3 gene in first episode MDD patients.


Keywords

  • ANK3
  • Aging
  • Cortical thickness
  • Major depressive disorder
  • Neuroimage

AOX1

N1-Methylnicotinamide: An Anti-Ovarian Aging Hormetin?


Keywords

  • AMPK
  • MNAM
  • Ovarian Aging
  • ROS

AP2B1

Circular RNA NF1-419 enhances autophagy to ameliorate senile dementia by binding Dynamin-1 and Adaptor protein 2 B1 in AD-like mice.


MeSH Terms

  • Adaptor Protein Complex beta Subunits
  • Aging
  • Alzheimer Disease
  • Animals
  • Astrocytes
  • Autophagy
  • Cellular Senescence
  • Dynamin I
  • Genes, Neurofibromatosis 1
  • Mice
  • RNA, Circular
  • Rats
  • Rats, Sprague-Dawley

Keywords

  • aging
  • astrocyte
  • autophagy
  • biological function
  • circular RNA

APC

Differences between blacks and whites in well-being, beliefs, emotional states, behaviors and survival, 1978-2014.


MeSH Terms

  • Adult
  • African Americans
  • Aged
  • Behavior
  • Cohort Studies
  • Emotions
  • European Continental Ancestry Group
  • Female
  • Hispanic Americans
  • Humans
  • Longevity
  • Male
  • Middle Aged
  • Socioeconomic Factors
  • Survival Analysis
  • United States


Wnt-induced, TRP53-mediated Cell Cycle Arrest of Precursors Underlies Interstitial Cell of Cajal Depletion During Aging.


Keywords

  • Compliance
  • Senescence
  • Stem Cell


Burden of musculoskeletal disorders in Iran during 1990-2017: estimates from the Global Burden of Disease Study 2017.


MeSH Terms

  • Female
  • Global Burden of Disease
  • Global Health
  • Humans
  • Iran
  • Life Expectancy
  • Male
  • Musculoskeletal Diseases
  • Quality-Adjusted Life Years

Keywords

  • Burden
  • DALY
  • Decomposition
  • Global burden of diseases
  • Iran
  • Musculoskeletal diseases


Fall-related mortality trends in older Japanese adults aged ≥65 years: a nationwide observational study.


MeSH Terms

  • Accidental Falls
  • Aged
  • Aged, 80 and over
  • Female
  • Geriatrics
  • Health Policy
  • Health Services Needs and Demand
  • Humans
  • Japan
  • Male
  • Mortality
  • Public Health

Keywords

  • adult intensive & critical care
  • epidemiology
  • geriatric medicine
  • health & safety
  • health policy
  • public health


Stroke Mortality Rates and Trends in Romania, 1994-2017.


MeSH Terms

  • Adult
  • Age Distribution
  • Aged
  • Aged, 80 and over
  • Cause of Death
  • Female
  • Humans
  • Life Expectancy
  • Male
  • Middle Aged
  • Prognosis
  • Registries
  • Risk Assessment
  • Risk Factors
  • Romania
  • Sex Distribution
  • Stroke
  • Time Factors

Keywords

  • Mortality
  • age-standardized mortality rates
  • life expectancy
  • stroke


A new approach to quantifying the EEG during walking: Initial evidence of gait related potentials and their changes with aging and dual tasking.


MeSH Terms

  • Accelerometry
  • Adult
  • Aged
  • Aging
  • Electroencephalography
  • Evoked Potentials
  • Exercise Test
  • Female
  • Gait
  • Humans
  • Male
  • Middle Aged
  • Multitasking Behavior
  • Reaction Time
  • Walking

Keywords

  • Dual task
  • EEG
  • Gait cycle
  • Gait related potentials (GRP)

APOC3

Positional Obstructive Sleep Apnea Syndrome in Elderly Patients.


MeSH Terms

  • Adult
  • Aged
  • Humans
  • Middle Aged
  • Polysomnography
  • Posture
  • Prospective Studies
  • Sleep Apnea, Obstructive
  • Supine Position
  • Young Adult

Keywords

  • aging effects
  • obstructive sleep apnea
  • polysomnography
  • positional sleep apnea

APOE

Polygenic risk score of longevity predicts longer survival across an age-continuum.


Keywords

  • centenarians
  • cognitive health
  • genetics
  • healthy aging
  • longevity


Association Between APOE Alleles and Change of Neuropsychological Tests in the Long Life Family Study.


Keywords

  • APOE
  • cognition
  • longevity
  • longitudinal studies


The APOE gene cluster responds to air pollution factors in mice with coordinated expression of genes that differs by age in humans.


Keywords

  • Alzheimer's disease
  • aging
  • air pollution
  • apolipoprotein E
  • chromosome 19q13


Homozygosity in the [i]APOE[/i] 3 Polymorphism Is Associated With Less Depression and Higher Serum Low-Density Lipoprotein in Chinese Elderly Schizophrenics.


Keywords

  • APOE E3
  • Chinese
  • aging
  • depressive symptom
  • schizophrenia


Effect of apolipoprotein E polymorphism on cognition and brain in the Cambridge Centre for Ageing and Neuroscience cohort.


Keywords

  • Cognition
  • ageing
  • apolipoprotein E
  • brain
  • lifespan


Cardiovascular risk factors and APOE-ε4 status affect memory functioning in aging via changes to temporal stem diffusion.


Keywords

  • APOE
  • BMI
  • RRID:SCR_001398
  • RRID:SCR_002403
  • RRID:SCR_002823
  • RRID:SCR_002865
  • RRID:SCR_007037
  • aging
  • diffusion tensor imaging
  • hypertension
  • memory
  • path modeling


APOE [i]ε[/i]4 and resting-state functional connectivity in racially/ethnically diverse older adults.


Keywords

  • APOE ε4 differences
  • brain aging
  • dementia
  • neuroimaging
  • racial/ethnic differences
  • resting‐state functional connectivity


Predictors of Olfactory Decline in Aging: A Longitudinal Population-Based Study.


Keywords

  • Cognitive aging
  • Epidemiology
  • Olfactory
  • Olfactory impairment


When Culture Influences Genes: Positive Age Beliefs Amplify the Cognitive-Aging Benefit of APOE ε2.


Keywords

         APOE
       
  • Age beliefs
  • Cognition
  • Gene
  • Health and Retirement Study
  • Self-perceptions of aging


Age and the association between apolipoprotein E genotype and Alzheimer disease: A cerebrospinal fluid biomarker-based case-control study.


MeSH Terms

  • Adult
  • Aged
  • Aged, 80 and over
  • Aging
  • Alzheimer Disease
  • Apolipoprotein E4
  • Biomarkers
  • Case-Control Studies
  • Cohort Studies
  • Female
  • Genotype
  • Humans
  • Male
  • Middle Aged


Estimating the potential for dementia prevention through modifiable risk factors elimination in the real-world setting: a population-based study.


Keywords

  • Aging
  • Alzheimer’s disease
  • Dementia
  • Dementia prevention
  • Modifiable risk factors
  • Population attributable fraction
  • Public health


Machine learning-based estimation of cognitive performance using regional brain MRI markers: the Northern Manhattan Study.


Keywords

  • Biomarkers
  • Brain aging
  • Cognitive aging
  • Machine learning


Effects of an APOE Promoter Polymorphism on Fronto-Parietal Functional Connectivity During Nondemented Aging.


Keywords

  • APOE promoter
  • aging
  • brain connectome
  • fronto-parietal network
  • working memory


The relationship of parental longevity with the aging brain-results from UK Biobank.


Keywords

  • Aging
  • Brain structure
  • DTI
  • MRI
  • Neuroimaging
  • Parental longevity


Alzheimer's Patient Microglia Exhibit Enhanced Aging and Unique Transcriptional Activation.


Keywords

  • Alzheimer’s disease
  • aging
  • microglia
  • neurodegenerative diseases
  • neuroinflammation
  • transcriptomics


Relationships Between Plasma Lipids Species, Gender, Risk Factors, and Alzheimer's Disease.


Keywords

  • APOEɛ4
  • Aging
  • Alzheimer’s disease
  • gender
  • lipid

species


Effects of sex, age, and apolipoprotein E genotype on hippocampal parenchymal fraction in cognitively normal older adults.


MeSH Terms

  • Age Factors
  • Aged
  • Aged, 80 and over
  • Apolipoproteins E
  • Biomarkers
  • Cognition
  • Databases, Factual
  • Female
  • Genotype
  • Hippocampus
  • Humans
  • Linear Models
  • Male
  • Middle Aged
  • Neuroimaging
  • Organ Size
  • Parenchymal Tissue
  • Reference Values
  • Sex Factors

Keywords

  • Alzheimer’s disease
  • Apolipoprotein E ϵ4
  • Atrophy
  • Brain
  • Healthy aging
  • Hippocampal parenchymal fraction
  • Hippocampal volumetric integrity
  • Hippocampus
  • MRI
  • Mild cognitive impairment
  • Neurodegeneration
  • Sex


Cognitive Health of Nonagenarians in Southern Italy: A Descriptive Analysis from a Cross-Sectional, Home-Based Pilot Study of Exceptional Longevity (Cilento Initiative on Aging Outcomes Or CIAO).


Keywords

  • Cilento Region
  • cognitive health
  • lifestyle
  • longevity


Apolipoprotein E and Health in Older Men: The Concord Health and Ageing in Men Project.


Keywords

  • Aging
  • Alzheimer’s disease
  • Apolipoprotein E
  • Cognition
  • Cognitive frailty
  • Frailty
  • Male


CSF amyloid is a consistent predictor of white matter hyperintensities across the disease course from aging to Alzheimer's disease.


MeSH Terms

  • Aged
  • Aged, 80 and over
  • Aging
  • Alzheimer Disease
  • Amyloid beta-Peptides
  • Biomarkers
  • Cerebrovascular Disorders
  • Cognitive Dysfunction
  • Female
  • Humans
  • Magnetic Resonance Imaging
  • Male
  • Peptide Fragments
  • White Matter
  • tau Proteins

Keywords

  • Alzheimer's disease
  • Amyloid
  • Cerebrospinal fluid
  • Tau
  • Vascular disease
  • White matter hyperintensities


Association of Cardiovascular Risk Factors with Cerebral Perfusion in Whites and African Americans.


Keywords

  • Aging
  • Alzheimer’s disease
  • blood pressure
  • cerebrovascular circulation
  • neuroimaging
  • obesity


Alzheimer's Risk Factors Age, APOE Genotype, and Sex Drive Distinct Molecular Pathways.


MeSH Terms

  • Adaptor Proteins, Signal Transducing
  • Age Factors
  • Aging
  • Alzheimer Disease
  • Animals
  • Apolipoprotein E2
  • Apolipoprotein E3
  • Apolipoprotein E4
  • Apolipoproteins E
  • Brain
  • Female
  • Gene Expression
  • Gene Expression Profiling
  • Gene Regulatory Networks
  • Genotype
  • Humans
  • Male
  • Membrane Glycoproteins
  • Membrane Proteins
  • Metabolome
  • Mice
  • Mice, Transgenic
  • Protective Factors
  • Receptors, Immunologic
  • Risk Factors
  • Serpins
  • Sex Factors
  • Unfolded Protein Response

Keywords

  • APOE
  • Alzheimer’s disease
  • Serpina3
  • age
  • extracellular vesicles
  • inflammation
  • lipid metabolism
  • metabolomics
  • sex
  • transcriptomics


Less agreeable, better preserved? A PET amyloid and MRI study in a community-based cohort.


MeSH Terms

  • Aged
  • Aged, 80 and over
  • Amyloidogenic Proteins
  • Apolipoproteins E
  • Brain
  • Cognition
  • Cohort Studies
  • Female
  • Follow-Up Studies
  • Humans
  • Magnetic Resonance Imaging
  • Male
  • Neuroimaging
  • Organ Size
  • Personality
  • Positron-Emission Tomography

Keywords

  • Amyloid load
  • Cognitive aging
  • Cohort studies
  • Personality
  • Structural MRI


Physical Activity as Moderator of the Association Between APOE and Cognitive Decline in Older Adults: Results from Three Longitudinal Cohort Studies.


Keywords

  • Gene–environment interaction
  • InCHIANTI
  • Longitudinal Aging Study Amsterdam
  • Rotterdam Study


Longitudinal Maintenance of Cognitive Health in Centenarians in the 100-plus Study.


MeSH Terms

  • Aged, 80 and over
  • Aging
  • Apolipoprotein E4
  • Cognition
  • Female
  • Humans
  • Longitudinal Studies
  • Male
  • Mental Status and Dementia Tests
  • Prospective Studies


Interaction of APOE, cerebral blood flow, and cortical thickness in the entorhinal cortex predicts memory decline.


Keywords

  • APOE ε4
  • Aging
  • Cerebral blood flow
  • Cognitive decline
  • Cortical thickness


Determinants of mesial temporal lobe volume loss in older individuals with preserved cognition: a longitudinal PET amyloid study.


MeSH Terms

  • Aged
  • Aged, 80 and over
  • Aging
  • Alleles
  • Amyloidogenic Proteins
  • Apolipoprotein E4
  • Cognitive Reserve
  • Female
  • Follow-Up Studies
  • Genotype
  • Humans
  • Longitudinal Studies
  • Male
  • Neuropsychological Tests
  • Organ Size
  • Positron-Emission Tomography
  • Sex Factors
  • Temporal Lobe

Keywords

  • APOE
  • Amyloid load
  • Cognitive changes
  • Mesial temporal lobe
  • Normal aging
  • Structural MRI


Long-term exposure to ambient air pollution, APOE-ε4 status, and cognitive decline in a cohort of older adults in northern Manhattan.


MeSH Terms

  • Aged
  • Air Pollutants
  • Air Pollution
  • Apolipoprotein E4
  • Apolipoproteins E
  • Cognitive Dysfunction
  • Female
  • Genotype
  • Humans
  • Male
  • Prospective Studies
  • Washington

Keywords

  • APOE-ε4 allele
  • Aging
  • Air pollution
  • Cognitive decline
  • Cognitive risk factors
  • Epidemiology


Evidence in support of chromosomal sex influencing plasma based metabolome vs APOE genotype influencing brain metabolome profile in humanized APOE male and female mice.


MeSH Terms

  • Age of Onset
  • Aging
  • Alzheimer Disease
  • Amyloid beta-Peptides
  • Animals
  • Apolipoprotein E4
  • Apolipoproteins E
  • Brain
  • Disease Models, Animal
  • Female
  • Genotype
  • Humans
  • Magnetic Resonance Imaging
  • Male
  • Metabolome
  • Mice
  • Mice, Transgenic
  • Sex Characteristics
  • Sex Chromosomes


APOE region molecular signatures of Alzheimer's disease across races/ethnicities.


MeSH Terms

  • Alleles
  • Alzheimer Disease
  • Apolipoproteins E
  • Continental Population Groups
  • Haplotypes
  • Heterozygote
  • Homozygote
  • Humans
  • Linkage Disequilibrium
  • Polymorphism, Single Nucleotide
  • Risk Factors

Keywords

  • APOE polymorphism
  • Aging
  • Alzheimer's disease
  • Health span
  • Life span
  • Neurodegenerative disorders


Varying Effects of APOE Alleles on Extreme Longevity in European Ethnicities.


MeSH Terms

  • Aged, 80 and over
  • Alleles
  • Apolipoproteins E
  • Ethnic Groups
  • Europe
  • European Continental Ancestry Group
  • Female
  • Humans
  • Longevity
  • Male

Keywords

  • APOE
  • Bioinformatics
  • Human genetics
  • Longevity


Prospective Evaluation of Cognitive Health and Related Factors in Elderly at Risk for Developing Alzheimer's Dementia: A Longitudinal Cohort Study.


MeSH Terms

  • Aged
  • Aged, 80 and over
  • Alzheimer Disease
  • Anxiety
  • Apolipoprotein E4
  • Cognition
  • Cognitive Dysfunction
  • Cohort Studies
  • Depression
  • Efficiency
  • Female
  • Healthy Volunteers
  • Humans
  • Longitudinal Studies
  • Male
  • Mental Status and Dementia Tests
  • Middle Aged
  • Neuropsychological Tests
  • Prospective Studies
  • Risk Factors
  • Sleep
  • United Kingdom
  • Work

Keywords

  • Alzheimer Disease
  • CHARIOT
  • aging registry
  • cognitive health
  • pre-clinical


Association of Cardiovascular and Alzheimer's Disease Risk Factors with Intracranial Arterial Blood Flow in Whites and African Americans.


MeSH Terms

  • African Americans
  • Aged
  • Alzheimer Disease
  • Biomarkers
  • Blood Flow Velocity
  • Cardiovascular Diseases
  • Cerebrovascular Circulation
  • European Continental Ancestry Group
  • Female
  • Humans
  • Male
  • Middle Aged
  • Risk Factors

Keywords

  • African Americans
  • Alzheimer’s disease
  • Apolipoprotein E4
  • aging
  • cerebrovascular circulation
  • glucose
  • metabolic syndrome
  • neuroimaging
  • risk factors


Is Ongoing Anticholinergic Burden Associated With Greater Cognitive Decline and Dementia Severity in Mild to Moderate Alzheimer's Disease?


Keywords

  • Alzheimers
  • Cognitive aging
  • Drug related
  • Medication


Multicenter Alzheimer's and Parkinson's disease immune biomarker verification study.


MeSH Terms

  • Age Factors
  • Aged
  • Aged, 80 and over
  • Alzheimer Disease
  • Amyloid
  • Biomarkers
  • Cohort Studies
  • Europe
  • Female
  • Humans
  • Inflammation
  • Male
  • Middle Aged
  • Parkinson Disease
  • Sex Factors
  • tau Proteins

Keywords

  • Aging
  • Alzheimer's disease
  • Amyloid
  • Biomarker
  • Cerebrospinal fluid
  • Inflammation
  • Mild cognitive impairment
  • Multicenter
  • Parkinson's disease
  • Tau


Prospective Memory: Age related change is influenced by APOE genotype.


Keywords

  • APOE
  • Alzheimer’s disease
  • aging
  • mid-adulthood
  • prospective memory


Education Moderates the Relation Between APOE ɛ4 and Memory in Nondemented Non-Hispanic Black Older Adults.


MeSH Terms

  • Adult
  • African Americans
  • Aged
  • Aged, 80 and over
  • Aging
  • Alzheimer Disease
  • Apolipoprotein E4
  • Cognitive Reserve
  • Educational Status
  • Executive Function
  • Female
  • Humans
  • Male
  • Memory
  • Memory, Episodic
  • Memory, Short-Term
  • Middle Aged
  • Neuropsychological Tests
  • Sex Characteristics

Keywords

  • APOE
  • African American
  • Alzheimer’s disease
  • cognitive reserve
  • educational attainment
  • episodic memory
  • genetic risk
  • neuropsychological evaluation


Apolipoprotein E ε4 allele effects on longitudinal cognitive trajectories are sex and age dependent.


MeSH Terms

  • Age Factors
  • Aged
  • Alleles
  • Apolipoprotein E4
  • Cognition Disorders
  • European Continental Ancestry Group
  • Executive Function
  • Female
  • Humans
  • Longitudinal Studies
  • Male
  • Memory
  • Neuropsychological Tests
  • Sex Factors

Keywords

  • Aging
  • Alzheimer's disease
  • Apolipoprotein E ε4
  • Cognitive decline
  • Sex


Interactive effect of age and APOE-ε4 allele load on white matter myelin content in cognitively normal middle-aged subjects.


MeSH Terms

  • Age Factors
  • Aged
  • Aging
  • Apolipoprotein E4
  • Female
  • Humans
  • Magnetic Resonance Imaging
  • Male
  • Middle Aged
  • Myelin Sheath
  • White Matter

Keywords

  • Aging
  • Alzheimer
  • Apolipoprotein E
  • Cognitively normal subjects
  • Myelination
  • T1w/T2w ratio
  • White matter integrity


APOE modifies the interaction of entorhinal cerebral blood flow and cortical thickness on memory function in cognitively normal older adults.


MeSH Terms

  • Aged
  • Aged, 80 and over
  • Apolipoproteins E
  • Cerebral Cortex
  • Cerebrovascular Circulation
  • Entorhinal Cortex
  • Female
  • Genotype
  • Humans
  • Linear Models
  • Male
  • Memory
  • Middle Aged

Keywords

  • APOE ε4
  • Aging
  • Alzheimer’s disease
  • Cerebral blood flow
  • Cognitive decline
  • Cortical thickness


When time's arrow doesn't bend: APOE-ε4 influences episodic memory before old age.


MeSH Terms

  • Adult
  • Alleles
  • Alzheimer Disease
  • Apolipoprotein E4
  • Cognition
  • Cognitive Aging
  • Female
  • Genotype
  • Humans
  • Linear Models
  • Male
  • Memory
  • Memory, Episodic
  • Middle Aged
  • Young Adult

Keywords

  • Alzheimer's diseas
  • Apolipoprotein E
  • Cognition
  • Episodic memory
  • Semantic memory


Cognitive-Motor Integration Performance Is Affected by Sex, APOE Status, and Family History of Dementia.


MeSH Terms

  • Aged
  • Apolipoproteins E
  • Cognition
  • Cognitive Dysfunction
  • Cross-Sectional Studies
  • Dementia
  • Female
  • Humans
  • Male
  • Medical History Taking
  • Middle Aged
  • Photic Stimulation
  • Psychomotor Performance
  • Sex Characteristics
  • Surveys and Questionnaires

Keywords

  • Aging
  • alzheimer’s disease
  • apolipoprotein E4
  • dementia risk
  • geriatric

assessment

  • motor skills
  • movement
  • visuomotor integration


Associations among amyloid status, age, and longitudinal regional brain atrophy in cognitively unimpaired older adults.


MeSH Terms

  • Aged
  • Aged, 80 and over
  • Aging
  • Amyloid beta-Peptides
  • Atrophy
  • Brain
  • Cognition
  • Cognitive Dysfunction
  • Databases, Factual
  • Female
  • Humans
  • Longitudinal Studies
  • Male
  • Middle Aged

Keywords

  • Aging
  • Alzheimer's disease
  • Amyloid-β
  • Brain atrophy


Cognitive function and neuropathological outcomes: a forward-looking approach.


MeSH Terms

  • Aged
  • Aged, 80 and over
  • Aging
  • Alzheimer Disease
  • Cognitive Dysfunction
  • Female
  • Humans
  • Male
  • Middle Aged

Keywords

  • Alzheimer’s disease
  • Cognition
  • Multi-state model
  • Neuropathology


APOE gene-dependent BOLD responses to a breath-hold across the adult lifespan.


MeSH Terms

  • Adult
  • Aged
  • Aging
  • Apolipoprotein E3
  • Apolipoprotein E4
  • Apolipoproteins E
  • Breath Holding
  • Cerebrovascular Circulation
  • Cross-Over Studies
  • Double-Blind Method
  • Female
  • Genotype
  • Hemodynamics
  • Humans
  • Longevity
  • Magnetic Resonance Imaging
  • Male
  • Middle Aged
  • Nitrates

Keywords

  • Ageing
  • Alzheimer's disease
  • Apolipoprotein E
  • BOLD fMRI
  • Breath-hold
  • Cerebrovascular reactivity

APP

Pre-symptomatic Caspase-1 inhibitor delays cognitive decline in a mouse model of Alzheimer disease and aging.


MeSH Terms

  • Aging
  • Alzheimer Disease
  • Amyloid beta-Peptides
  • Animals
  • Behavior, Animal
  • Cognitive Dysfunction
  • Cytokines
  • Dipeptides
  • Disease Models, Animal
  • Encephalitis
  • Female
  • Humans
  • Inflammation
  • Male
  • Memory Disorders
  • Mice
  • Mice, Inbred C57BL
  • Mice, Transgenic
  • Serpins
  • Spatial Memory
  • Viral Proteins
  • para-Aminobenzoates


Regorafenib Regulates AD Pathology, Neuroinflammation, and Dendritic Spinogenesis in Cells and a Mouse Model of AD.


Keywords

  • aging
  • amyloid beta
  • dendritic spine
  • neuroinflammation
  • regorafenib
  • tau


An agnostic reevaluation of the amyloid cascade hypothesis of Alzheimer's disease pathogenesis: The role of APP homeostasis.


Keywords

  • aging
  • amyloid hypothesis
  • amyloid precursor protein homeostasis
  • late onset Alzheimer's disease
  • young onset Alzheimer's disease


Transcriptomic profiling of microglia and astrocytes throughout aging.


Keywords

  • Aging
  • Alzheimer’s disease (AD)
  • Astrocyte
  • Microglia
  • RNA-seq


Platelets in Amyloidogenic Mice Are Activated and Invade the Brain.


Keywords

  • Alzheimer’s disease
  • aging
  • astrocytes
  • platelets
  • vascular pathology


CHIP modulates APP-induced autophagy-dependent pathological symptoms in Drosophila.


MeSH Terms

  • Alzheimer Disease
  • Amyloid beta-Protein Precursor
  • Animals
  • Aspartic Acid Endopeptidases
  • Autophagy
  • Brain
  • Cognitive Dysfunction
  • Disease Models, Animal
  • Dopaminergic Neurons
  • Down-Regulation
  • Drosophila
  • Drosophila Proteins
  • Eye
  • Learning Disabilities
  • Locomotion
  • Longevity
  • Nuclear Proteins
  • Presenilins
  • RNA Interference
  • Wings, Animal

Keywords

CHIP

  • APP
  • Alzheimer’s disease
  • autophagy


Studies on APP metabolism related to age-associated mitochondrial dysfunction in APP/PS1 transgenic mice.


MeSH Terms

  • Adenosine Triphosphate
  • Aging
  • Alzheimer Disease
  • Amyloid beta-Protein Precursor
  • Animals
  • Blood Platelets
  • Disease Models, Animal
  • Hippocampus
  • Mice
  • Mice, Inbred C57BL
  • Mice, Transgenic
  • Mitochondria
  • Presenilin-1

Keywords

  • APP/PS1 mice
  • Amyloid-beta
  • adenosine 5’-triphosphate
  • mitochondria dysfunction
  • platelets


Intermittent Hypoxia-Hyperoxia Training Improves Cognitive Function and Decreases Circulating Biomarkers of Alzheimer's Disease in Patients with Mild Cognitive Impairment: A Pilot Study.


MeSH Terms

  • Aged
  • Alzheimer Disease
  • Biomarkers
  • Case-Control Studies
  • Cognition
  • Cognitive Dysfunction
  • Female
  • Humans
  • Hyperoxia
  • Hypoxia
  • Male
  • Middle Aged
  • Pilot Projects
  • Respiratory Therapy
  • Treatment Outcome

Keywords

  • Alzheimer’s disease
  • adaptation
  • aging
  • amyloid beta
  • biomarker
  • cognitive function
  • hyperoxia
  • intermittent hypoxia
  • platelets


The Implication of Androgens in the Presence of Protein Kinase C to Repair Alzheimer’s Disease-Induced Cognitive Dysfunction


MeSH Terms

  • Adult
  • Aged
  • Aged, 80 and over
  • Aging
  • Alzheimer Disease
  • Amyloid Precursor Protein Secretases
  • Amyloid beta-Peptides
  • Androgens
  • Aspartic Acid Endopeptidases
  • Cognition
  • Cognitive Dysfunction
  • Cyclic AMP Response Element-Binding Protein
  • Female
  • Hippocampus
  • Humans
  • Learning
  • MAP Kinase Signaling System
  • Male
  • Middle Aged
  • Neoplasm Proteins
  • Phosphorylation
  • Protein Kinase C
  • Receptors for Activated C Kinase
  • tau Proteins

Keywords

  • Androgens
  • Cognition
  • Hippocampus
  • Protein kinase C
  • Spatial memory


Modulation of Neural and Muscular Adaptation Processes During Resistance Training by Fish Protein Ingestions in Older Adults.


Keywords

  • Aging
  • Alaska pollack protein
  • Motor unit identification
  • Multichannel surface electromyography
  • Nutritional supplementation


Antipsychotic Polypharmacy in Older Adult Asian Patients With Schizophrenia: Research on Asian Psychotropic Prescription Pattern.


MeSH Terms

  • Aged
  • Aged, 80 and over
  • Aging
  • Antipsychotic Agents
  • Asian Continental Ancestry Group
  • Female
  • Humans
  • Male
  • Middle Aged
  • Polypharmacy
  • Schizophrenia

Keywords

  • Asian
  • antipsychotic polypharmacy
  • older adult patients
  • schizophrenia


A pleiotropic role for exosomes loaded with the amyloid β precursor protein carboxyl-terminal fragments in the brain of Down syndrome patients.


MeSH Terms

  • Amyloid beta-Protein Precursor
  • Brain
  • Down Syndrome
  • Exosomes
  • Humans

Keywords

  • APP
  • APP-CTFs
  • Aging
  • Brain
  • Down syndrome
  • Exosomes
  • Extracellular vesicles

APPL1

Insulin and adipokine signaling and their cross-regulation in postmortem human brain.


MeSH Terms

  • Adipokines
  • Aging
  • Brain
  • Humans
  • Insulin
  • Leptin
  • Postmortem Changes
  • Signal Transduction

Keywords

  • Adipokine
  • Adiponectin receptors
  • Alzheimer's disease–related dementias
  • Leptin receptors
  • Postmortem brain
  • Type 2 diabetes
  • insulin signaling

AQP3

Transbuccal platform for delivery of lipogenic actives to facial skin: Because fat matters.


Keywords

  • adipocytes
  • aging
  • cosmetics
  • face
  • fat pads
  • integument
  • subcutis
  • wrinkles

AR

Mechanisms of Androgen Receptor Agonist- and Antagonist-Mediated Cellular Senescence in Prostate Cancer.


Keywords

  • PKB/Akt
  • Src
  • androgen receptor antagonist
  • antiandrogen
  • bipolar androgen therapy
  • cellular senescence
  • prostate cancer
  • supraphysiological androgen levels


Interleukin-23 Represses the Level of Cell Senescence Induced by the Androgen Receptor Antagonists Enzalutamide and Darolutamide in Castration-Resistant Prostate Cancer Cells.


Keywords

  • Androgen receptor antagonists
  • Cellular senescence
  • Interleukin-23
  • Prostate cancer spheroids


A Landscape of Murine Long Non-Coding RNAs Reveals the Leading Transcriptome Alterations in Adipose Tissue during Aging.


Keywords

  • adipocyte
  • adipose tissue
  • aging
  • lncRNA
  • long non-coding RNA
  • non-coding RNA
  • transcriptome


Senolytic compounds control a distinct fate of androgen receptor agonist- and antagonist-induced cellular senescent LNCaP prostate cancer cells.


Keywords

  • Akt inhibitor
  • Antiandrogen
  • Bcl-2 family inhibitor
  • Bipolar androgen therapy
  • Cellular senescence
  • HSP90 inhibitor
  • Prostate cancer
  • Senolytic compounds


Role of gut microbiota in sex- and diet-dependent metabolic disorders that lead to early mortality of androgen receptor-deficient male mice.


MeSH Terms

  • Adipocytes
  • Adipose Tissue
  • Animals
  • Anti-Bacterial Agents
  • Diet
  • Diet, High-Fat
  • Feces
  • Female
  • Gastrointestinal Microbiome
  • Lipid Metabolism
  • Longevity
  • Male
  • Metabolic Diseases
  • Mice
  • Mice, Inbred C57BL
  • Mice, Knockout
  • Obesity
  • Receptors, Androgen
  • Sex Characteristics

Keywords

  • androgen-insensitive syndrome
  • longevity
  • metabolic syndrome
  • testosterone
  • type 2 diabetes


A jaboticaba extract prevents prostatic damage associated with aging and high-fat diet intake.


MeSH Terms

  • Aging
  • Animals
  • Cell Proliferation
  • Diet, High-Fat
  • Male
  • Mice
  • Myrtaceae
  • Plant Extracts
  • Prostate


Identifying blood-specific age-related DNA methylation markers on the Illumina MethylationEPIC® BeadChip.


MeSH Terms

  • Adolescent
  • Adult
  • Aged
  • Aged, 80 and over
  • Aging
  • Child
  • Child, Preschool
  • Cohort Studies
  • CpG Islands
  • DNA Methylation
  • Forensic Genetics
  • Genetic Markers
  • Humans
  • Infant
  • Infant, Newborn
  • Linear Models
  • Middle Aged
  • Oligonucleotide Array Sequence Analysis
  • Young Adult

Keywords

  • Age
  • CpG sites
  • DNA methylation
  • Forensic age estimation
  • Forensic epigenetics
  • Illumina MethylationEPIC

ARC

The Polymorphism rs2968 of [i]LSS[/i] Gene Confers Susceptibility to Age-Related Cataract.


MeSH Terms

  • Aged
  • Aging
  • Alleles
  • Cataract
  • Female
  • Gene Expression Regulation
  • Genetic Association Studies
  • Genetic Predisposition to Disease
  • Genotype
  • Haplotypes
  • Humans
  • Hydroxymethylglutaryl CoA Reductases
  • Intramolecular Transferases
  • Lens, Crystalline
  • Male
  • Middle Aged
  • Polymorphism, Single Nucleotide

Keywords

  • ARC
  • HMGCR
  • LSS
  • SNPs
  • lanosterol


Decreased Anti-Müllerian hormone and Anti-Müllerian hormone receptor type 2 in hypothalami of old Japanese Black cows.


Keywords

  • Müllerian inhibiting substance
  • female reproductive senescence
  • gonadotropin-releasing hormone neuron
  • preoptic area
  • ruminant


Resveratrol delay the cataract formation against naphthalene-induced experimental cataract in the albino rats.


MeSH Terms

  • Animals
  • Cataract
  • Dose-Response Relationship, Drug
  • Male
  • Naphthalenes
  • Rats
  • Rats, Sprague-Dawley
  • Resveratrol

Keywords

  • age-related cataracts
  • aging
  • oxidative stress
  • resveratrol

AREG

Targeting amphiregulin (AREG) derived from senescent stromal cells diminishes cancer resistance and averts programmed cell death 1 ligand (PD-L1)-mediated immunosuppression.


MeSH Terms

  • Amphiregulin
  • Animals
  • Antineoplastic Agents
  • B7-H1 Antigen
  • Cells, Cultured
  • Cellular Senescence
  • Drug Resistance, Neoplasm
  • Humans
  • Mice
  • Mice, Inbred NOD
  • Mice, SCID
  • Stromal Cells
  • Tumor Microenvironment

Keywords

  • aging
  • amphiregulin
  • cancer resistance
  • clinical biomarker
  • combinational treatment
  • programmed cell death 1 ligand
  • senescence-associated secretory phenotype
  • stroma

ARNT

Loss of ARNT in skeletal muscle limits muscle regeneration in aging.


Keywords

  • aging
  • hypoxia signaling
  • muscle regeneration


[Arylhydrocarbon receptor nuclear translocator (ARNT) in human skin during aging.]


MeSH Terms

  • Adolescent
  • Adult
  • Aged
  • Aged, 80 and over
  • Aging
  • Aryl Hydrocarbon Receptor Nuclear Translocator
  • Child
  • Child, Preschool
  • Dermis
  • Fetus
  • Fibroblasts
  • Humans
  • Infant
  • Infant, Newborn
  • Skin
  • Skin Aging
  • Young Adult

Keywords

  • ARNT
  • PCNA
  • aging
  • fibroblasts
  • skin


The E3 ubiquitin ligase STUB1 attenuates cell senescence by promoting the ubiquitination and degradation of the core circadian regulator BMAL1.


Keywords

  • E3 ubiquitin ligase
  • STIP1 homology and U-box-containing protein 1 (STUB1)
  • brain and muscle ARNT-like 1 (BMAL1, ARNTL, MOP3)
  • cell cycle regulation
  • circadian clock
  • hydrogen peroxide
  • proteasome
  • protein degradation
  • senescence
  • ubiquitylation (ubiquitination)

ASB7

ASB7 Is a Novel Regulator of Cytoskeletal Organization During Oocyte Maturation.


Keywords

  • ASBs
  • maternal aging
  • meiosis
  • oocyte
  • reproduction

ASL

Increased blood-brain barrier permeability to water in the aging brain detected using noninvasive multi-TE ASL MRI.


Keywords

  • aging
  • aquaporin-4
  • arterial spin labeling
  • blood-brain barrier
  • blood-brain interface
  • water permeability


Quantitative Cerebrovascular Reactivity in Normal Aging: Comparison Between Phase-Contrast and Arterial Spin Labeling MRI.


Keywords

  • MRI
  • aging
  • arterial spin labeling
  • cerebrovascular reactivity
  • phase-contrast


Correcting Task fMRI Signals for Variability in Baseline CBF Improves BOLD-Behavior Relationships: A Feasibility Study in an Aging Model.


Keywords

  • BOLD deactivation
  • aging
  • cerebral blood flow
  • domain-general
  • language fMRI
  • semantic fluency
  • sensitization

ASXL1

ASXL1 mutation in clonal hematopoiesis.


MeSH Terms

  • Aged
  • Aging
  • Animals
  • Clonal Evolution
  • Codon, Nonsense
  • Hematologic Neoplasms
  • Hematopoiesis
  • Humans
  • Myeloproliferative Disorders
  • Neoplasm Proteins
  • Repressor Proteins

ATF4

Endoplasmic Reticulum Stress Mediates Vascular Smooth Muscle Cell Calcification via Increased Release of Grp78-Loaded Extracellular Vesicles.


Keywords

  • aging
  • arteries
  • endoplasmic reticulum
  • vascular calcification
  • warfarin

ATF6

Cellular proteostasis decline in human senescence.


Keywords

  • UPR
  • chaperones
  • heat shock response
  • protein homeostasis
  • senescence


Impact of endoplasmic reticulum stress on oocyte aging mechanisms.


Keywords

  • ER stress
  • GRP78
  • PERK
  • eIF2α
  • endoplasmic reticulum
  • mouse oocyte
  • oocyte aging
  • salubrinal


ER stress activates immunosuppressive network: implications for aging and Alzheimer's disease.


Keywords

  • Ageing
  • Immunometabolism
  • Immunosenescence
  • Immunosuppression
  • Inflammaging
  • Neurodegeneration


Towards Age-Related Anti-Inflammatory Therapy: Klotho Suppresses Activation of ER and Golgi Stress Response in Senescent Monocytes.


Keywords

  • ER stress response
  • Golgi apparatus/complex stress response
  • SASP
  • immunosenescence
  • klotho
  • monocytes

ATG3

Estrogen Signaling Induces Mitochondrial Dysfunction-Associated Autophagy and Senescence in Breast Cancer Cells.


Keywords

  • Estrogen
  • MCF-7
  • MDA-MB-231
  • autophagy
  • mitochondria
  • senescence

ATG5

Autophagy and heat-shock response impair stress granule assembly during cellular senescence.


Keywords

  • Ageing
  • Cellular senescence
  • Molecular biology
  • Oxidative stress
  • Stress granules

ATG7

Age-related impairment of autophagy in cervical motor neurons.


Keywords

  • Aging
  • Autophagy
  • Motor neuron
  • Neuromuscular dysfunction
  • Spinal cord


Comprehensive Bioinformatics Identifies Key microRNA Players in ATG7-Deficient Lung Fibroblasts.


Keywords

  • autophagy
  • bioinformatics
  • functional network analysis
  • lung fibrosis
  • miR
  • proteomics
  • senescence


Regulation of autophagy by DNA G-quadruplexes.


Keywords

  • G-quadruplex
  • aging
  • astrocytes
  • autophagy
  • neurodegeneration
  • neurons


ATG7 is essential for secretion of iron from ameloblasts and normal growth of murine incisors during aging.


Keywords

  • ATG7
  • Aging
  • ameloblast
  • autophagy
  • epithelium
  • ferritin
  • hyperplasia
  • iron
  • secretion
  • tooth


Enhancing Autophagy Diminishes Aberrant Ca Homeostasis and Arrhythmogenesis in Aging Rabbit Hearts.


Keywords

  • aging
  • autophagy
  • calcium
  • cardiac physiology
  • ryanodine receptor

ATM

SATMF Suppresses the Premature Senescence Phenotype of the ATM Loss-of-Function Mutant and Improves Its Fertility in [i]Arabidopsis[/i].


Keywords

  • ATM
  • DNA damage
  • SATMF
  • fertility
  • leaf senescence


ATM mediated-p53 signaling pathway forms a novel axis for senescence control.


Keywords

  • ATM inhibition
  • Metabolic reprogrammer
  • Mitochondria
  • P53
  • Senescence alleviation


Non-canonical ATM/MRN activities temporally define the senescence secretory program.


Keywords

  • DNA damage response
  • MRN complex
  • NF-κB
  • chromatin
  • senescence secretome


ATM is a key driver of NF-κB-dependent DNA-damage-induced senescence, stem cell dysfunction and aging.


Keywords

  • ATM
  • DNA damage response
  • NF-κB
  • aging
  • cellular senescence


ATM suppresses leaf senescence triggered by DNA double-strand break through epigenetic control of senescence-associated genes in Arabidopsis.


Keywords

Arabidopsis thaliana

  • ATM
  • DNA repair
  • double-strand breaks
  • histone methylation
  • leaf senescence


Glioblastoma Cells Do Not Affect Axitinib-Dependent Senescence of HUVECs in a Transwell Coculture Model.


MeSH Terms

  • Ataxia Telangiectasia Mutated Proteins
  • Axitinib
  • Cell Line, Tumor
  • Cellular Senescence
  • Coculture Techniques
  • Gene Expression Profiling
  • Glioblastoma
  • Human Umbilical Vein Endothelial Cells
  • Humans
  • Phosphorylation

Keywords

  • Axitinib
  • endothelial cells
  • glioblastoma
  • senescence


Declining BRCA-Mediated DNA Repair in Sperm Aging and its Prevention by Sphingosine-1-Phosphate.


Keywords

  • Aging
  • DNA fragmentation
  • Gene expression
  • Sperm


BRCA-related ATM-mediated DNA double-strand break repair and ovarian aging.


MeSH Terms

  • Aging
  • Animals
  • Ataxia Telangiectasia
  • BRCA1 Protein
  • BRCA2 Protein
  • DNA Breaks, Double-Stranded
  • DNA Repair
  • Female
  • Fertility
  • Fertility Preservation
  • Humans
  • Mice
  • Oocytes
  • Ovarian Follicle
  • Ovarian Reserve
  • Ovary

Keywords

         BRCA
       
         BRCA1/2
       
  • DNA repair
  • anti-Mullerian hormone
  • chemotherapy
  • mutations
  • oocyte
  • ovarian aging
  • ovarian reserve
  • ovarian response


ATM Deficiency Accelerates DNA Damage, Telomere Erosion, and Premature T Cell Aging in HIV-Infected Individuals on Antiretroviral Therapy.


MeSH Terms

  • Anti-Retroviral Agents
  • Ataxia Telangiectasia Mutated Proteins
  • Cellular Senescence
  • DNA Damage
  • HIV Infections
  • Humans
  • T-Lymphocytes
  • Telomere

Keywords

  • ATM
  • DNA damage repair
  • HIV
  • T cell homeostasis
  • apoptosis
  • immune aging


SMG1 heterozygosity exacerbates haematopoietic cancer development in Atm null mice by increasing persistent DNA damage and oxidative stress.


MeSH Terms

  • Animals
  • Ataxia Telangiectasia Mutated Proteins
  • Carcinogenesis
  • Cells, Cultured
  • DNA Damage
  • Embryo, Mammalian
  • Fibroblasts
  • Gamma Rays
  • Hematologic Neoplasms
  • Heterozygote
  • Kaplan-Meier Estimate
  • Longevity
  • Lymphoma
  • Mice, Inbred C57BL
  • Mice, Knockout
  • Oxidative Stress
  • Protein-Serine-Threonine Kinases

Keywords

  • DNA damage
  • cancer
  • inflammation
  • lymphoma
  • oxidative stress


LncRNA RP11-670E13.6, interacted with hnRNPH, delays cellular senescence by sponging microRNA-663a in UVB damaged dermal fibroblasts.


MeSH Terms

  • Cell Proliferation
  • Cellular Senescence
  • Fibroblasts
  • Heterogeneous-Nuclear Ribonucleoprotein Group F-H
  • Humans
  • MicroRNAs
  • RNA, Long Noncoding
  • Skin
  • Skin Aging
  • Ultraviolet Rays

Keywords

  • cellular senescence
  • dermal fibroblast
  • lncRNA
  • microRNA
  • ultraviolet B


Tel1/ATM Signaling to the Checkpoint Contributes to Replicative Senescence in the Absence of Telomerase.


MeSH Terms

  • Amino Acid Substitution
  • Ataxia Telangiectasia Mutated Proteins
  • Cell Cycle Checkpoints
  • Cell Division
  • Cellular Senescence
  • DNA Damage
  • DNA Replication
  • DNA, Single-Stranded
  • DNA-Binding Proteins
  • Intracellular Signaling Peptides and Proteins
  • Mutant Proteins
  • Protein-Serine-Threonine Kinases
  • Saccharomyces cerevisiae
  • Saccharomyces cerevisiae Proteins
  • Telomerase
  • Telomere
  • Telomere Shortening

Keywords

  • Tel1
  • checkpoint
  • replicative senescence
  • telomere

ATP7A

Adipocyte-specific disruption of ATPase copper transporting α in mice accelerates lipoatrophy.


MeSH Terms

  • 3T3-L1 Cells
  • Adipocytes
  • Adipose Tissue, White
  • Aging
  • Animals
  • Body Weight
  • Copper
  • Copper-Transporting ATPases
  • Diet, High-Fat
  • Energy Metabolism
  • Insulin Resistance
  • Lipid Metabolism
  • Lipodystrophy
  • Lipolysis
  • Mice
  • Mice, Knockout

Keywords

  • ATP7A
  • Adipose tissues
  • Copper
  • Insulin resistance
  • Lipoatrophy

ATR

Bloodstain age estimation through infrared spectroscopy and Chemometric models.


Keywords

  • Aging
  • Bloodstains
  • Chemometric
  • Forensic chemistry
  • MLR
  • PLSR


Artificial Intelligence and fourier-transform infrared spectroscopy for evaluating water-mediated degradation of lubricant oils.


Keywords

  • ANN
  • Artificial neural networks
  • FTIR
  • LDA
  • Linear discriminant analysis
  • Lubricant oil aging


Senescence Induction by Combined Ionizing Radiation and DNA Damage Response Inhibitors in Head and Neck Squamous Cell Carcinoma Cells.


Keywords

  • ATM
  • ATR
  • DNA damage response inhibitor
  • DNAPK
  • HNSCC
  • homologous recombination
  • ionizing radiation
  • kinase inhibitor
  • radiosensitivity
  • senescence


Kinetics of thermal degradation and lifetime study of poly(vinylidene fluoride) (PVDF) subjected to bioethanol fuel accelerated aging.


Keywords

  • Activation energy
  • Aging
  • Bioethanol fuel
  • Kinetics analysis
  • Lifetime prediction
  • Materials chemistry
  • Materials science
  • Poly(vinylidene fluoride)


Supraphysiological protection from replication stress does not extend mammalian lifespan.


Keywords

  • DNA damage
  • aging
  • cancer
  • mouse models
  • replication stress


Assessing the Retest Reliability of Prefrontal EEG Markers of Brain Rhythm Slowing in the Eyes-Closed Resting State.


Keywords

  • EEG
  • EEG slowing
  • brain aging
  • dominant frequency
  • prefrontal


Effects of Hydrogen Peroxide and Sodium Hypochlorite Aging on Properties and Performance of Polyethersulfone Ultrafiltration Membrane.


MeSH Terms

  • Humic Substances
  • Hydrogen Peroxide
  • Hydrophobic and Hydrophilic Interactions
  • Membranes, Artificial
  • Polymers
  • Sodium Hypochlorite
  • Sulfones
  • Ultrafiltration

Keywords

  • chemical cleaning
  • hydrogen peroxide (H2O2)
  • membrane aging
  • polyethersulfone (PES) ultrafiltration (UF) membrane
  • sodium hypochlorite (NaClO)


NF-κB signaling in skin aging.


MeSH Terms

  • Animals
  • Cellular Senescence
  • Humans
  • NF-kappa B
  • Phenotype
  • Signal Transduction
  • Skin Aging
  • Skin Neoplasms

Keywords

  • NF-κB
  • Senescence-associated secretory phenotype
  • Skin aging


Development of a w/o emulsion using ionic liquid strategy for transdermal delivery of anti - aging component α - lipoic acid: Mechanism of different ionic liquids on skin retention and efficacy evaluation.


MeSH Terms

  • Administration, Cutaneous
  • Animals
  • Emulsions
  • Hydroxyproline
  • Ionic Liquids
  • Male
  • Rats, Wistar
  • Skin
  • Skin Absorption
  • Skin Aging
  • Thioctic Acid
  • Ultraviolet Rays

Keywords

  • Anti – aging efficacy
  • Ionic liquids
  • Skin retention
  • Solubility
  • Α – lipoic acid


Effect of Nitrogen-Doped Graphene Oxide on the Aging Behavior of Nitrile-Butadiene Rubber.


Keywords

  • aging resistance
  • graphene oxide
  • nitrile-butadiene rubber
  • nitrogen-doped

AVP

Plasma oxytocin and vasopressin levels in young and older men and women: Functional relationships with attachment and cognition.


MeSH Terms

  • Adolescent
  • Adult
  • Age Factors
  • Aged
  • Aged, 80 and over
  • Aging
  • Anxiety
  • Avoidance Learning
  • Cognition
  • Cohort Studies
  • Female
  • Humans
  • Male
  • Middle Aged
  • Object Attachment
  • Oxytocin
  • Sex Factors
  • Vasopressins
  • Young Adult

Keywords

  • Age
  • Attachment anxiety
  • Oxytocin
  • Processing speed
  • Sex
  • Vasopressin

B4GALT1

Expression of β-1,4-galactosyltransferases during Aging in Caenorhabditis elegans.


Keywords

  • Biomarker
  • Glycosylation
  • Lifespan regulation
  • bre-4
  • sqv-3

BACE1

Electric Stimulation of Neurogenesis Improves Behavioral Recovery After Focal Ischemia in Aged Rats.


Keywords

  • aging
  • behavior
  • electrical stimulation
  • neurogenesis
  • rats
  • stroke


Disruption of synaptic expression pattern and age-related DNA oxidation in a neuronal model of lead-induced toxicity.


Keywords

  • Aging mice
  • Brain-derived neurotrophic factor precursor
  • Latent expression pattern
  • Lead
  • Pubertal exposure
  • Synaptic deficits
  • Tau phosphorylation

BAD

I imidazoline receptor modulation protects aged SAMP8 mice against cognitive decline by suppressing the calcineurin pathway.


Keywords

  • Aging
  • Alzheimer’s disease
  • Behavior
  • I2 imidazoline receptors
  • NFAT
  • Neuroinflammation
  • Neuroprotection

BAK1

Developmental Attenuation of Neuronal Apoptosis by Neural-Specific Splicing of Bak1 Microexon.


MeSH Terms

  • Animals
  • Apoptosis
  • Brain
  • Cell Line, Tumor
  • Cells, Cultured
  • Female
  • Heterogeneous-Nuclear Ribonucleoproteins
  • Male
  • Mice
  • Mice, Inbred C57BL
  • Mutation
  • Neural Stem Cells
  • Neurogenesis
  • Nonsense Mediated mRNA Decay
  • Polypyrimidine Tract-Binding Protein
  • RNA Splicing
  • bcl-2 Homologous Antagonist-Killer Protein

Keywords

  • AS-NMD
  • BAK
  • BCL2 family proteins
  • NMD
  • PTB
  • PTBP
  • PTBP2
  • UPF2
  • alternative splicing
  • cell death
  • neural development
  • neurogenesis
  • neuronal lifespan

BANF1

An additional case of Néstor-Guillermo progeria syndrome diagnosed in early childhood.


Keywords

  • BANF1
  • Néstor-Guillermo progeria syndrome
  • premature aging
  • progeria
  • whole exome sequencing

BATF

LncRNA-ES3 inhibition by Bhlhe40 is involved in high glucose-induced calcification/senescence of vascular smooth muscle cells.


Keywords

  • Bhlhe40
  • VSMC calcification/senescence
  • diabetes
  • lncRNA-ES3
  • microRNA
  • vascular aging

BAX

Clearance of therapy-induced senescent tumor cells by the senolytic ABT-263 via interference with BCL-X -BAX interaction.


Keywords

  • ABT-263
  • BCL-XL
  • chemotherapy
  • radiation
  • senescence
  • senolytic


CREB Signaling Mediates Dose-Dependent Radiation Response in the Murine Hippocampus Two Years after Total Body Exposure.


Keywords

  • CREB signaling
  • aging
  • brain
  • hippocampus
  • ionizing radiation
  • label-free proteomics

BAZ2B

Two conserved epigenetic regulators prevent healthy ageing.


MeSH Terms

  • Aging
  • Animals
  • Caenorhabditis elegans
  • Caenorhabditis elegans Proteins
  • Cognition
  • Cognitive Dysfunction
  • Epigenesis, Genetic
  • Healthy Aging
  • Histone-Lysine N-Methyltransferase
  • Histones
  • Humans
  • Longevity
  • Lysine
  • Male
  • Memory
  • Methylation
  • Mice
  • Mitochondria
  • Neurons
  • Proteins
  • RNA Interference
  • Spatial Learning
  • Transcription Factors, General

BCL6

Ecto-NTPDase CD39 is a negative checkpoint that inhibits follicular helper cell generation.


Keywords

  • Adaptive immunity
  • Aging
  • Cellular senescence
  • T cells
  • Vaccines

BCR

The presence of CLL-associated stereotypic B cell receptors in the normal BCR repertoire from healthy individuals increases with age.


Keywords

  • Aging
  • B-lymphocyte
  • BCR repertoire
  • CLL
  • Stereotypic BCR

BDNF

Influence of [i]BDNF[/i] Genetic Polymorphisms in the Pathophysiology of Aging-related Diseases.


Keywords

  • Aging
  • BDNF gene
  • aging-related diseases
  • polymorphism


Moderators of the Impact of (Poly)Phenols Interventions on Psychomotor Functions and BDNF: Insights from Subgroup Analysis and Meta-Regression.


Keywords

  • aging
  • antioxidant
  • brain functions
  • brain plasticity
  • cognition
  • psychomotor functions


Astroglia-Derived BDNF and MSK-1 Mediate Experience- and Diet-Dependent Synaptic Plasticity.


Keywords

  • AMPA receptors
  • Arc/Arg3.1
  • GABA receptors
  • TrkB receptors
  • aging
  • calcium signalling
  • dendritic spines
  • diet
  • enriched environment
  • glia-neuron interactions
  • ion conductance microscopy
  • synaptic scaling
  • synaptic strength


BDNF reverses aging-related microglial activation.


Keywords

  • Aging
  • BDNF
  • CREB
  • Microglial activation
  • NF-кB
  • TrkB


High Supervised Resistance Training in Elderly Women: The Role of Supervision Ratio.


Keywords

  • Aging
  • exercise
  • functional capacity
  • muscle strength


Metformin regulates astrocyte reactivity in Parkinson's disease and normal aging.


Keywords

  • Aging
  • Dorsal striatum
  • Metformin
  • Parkinson's disease
  • Reactive astrocyte


Aging-Induced Brain-Derived Neurotrophic Factor in Adipocyte Progenitors Contributes to Adipose Tissue Dysfunction.


Keywords

  • BDNF
  • adipocyte progenitors
  • adipose tissue
  • aging
  • sympathetic innervation


The Role of BDNF on Aging-Modulation Markers.


Keywords

  • BBB
  • astrocytes
  • brain aging
  • in vivo model
  • low dose BDNF


Spermidine and spermine delay brain aging by inducing autophagy in SAMP8 mice.


Keywords

  • aging
  • autophagy
  • mitochondrial dysfunction
  • polyamine


Microglia senescence occurs in both substantia nigra and ventral tegmental area.


Keywords

  • Parkinson's disease
  • aging-dependent neurodegeneration
  • dopamine neurons
  • microglia complexity
  • stereological analyses
  • tyrosine hydroxylase; microglia senescence


Towards an understanding of the physical activity-BDNF-cognition triumvirate: A review of associations and dosage.


MeSH Terms

  • Aging
  • Brain-Derived Neurotrophic Factor
  • Cognition
  • Exercise
  • Healthy Aging
  • Humans

Keywords

  • Ageing
  • BDNF
  • Brain
  • Physical activity


Impact of BDNF and sex on maintaining intact memory function in early midlife.


MeSH Terms

  • Brain
  • Brain-Derived Neurotrophic Factor
  • Cognition
  • Female
  • Humans
  • Magnetic Resonance Imaging
  • Male
  • Memory
  • Memory, Short-Term
  • Menopause
  • Middle Aged
  • Neuroprotective Agents
  • Neuropsychological Tests
  • Reproduction
  • Sex Characteristics

Keywords

  • Aging
  • BDNF
  • Hormones
  • Memory
  • Menopause
  • Sex differences


Testosterone replacement causes dose-dependent improvements in spatial memory among aged male rats.


Keywords

  • Aging
  • BDNF
  • Object location memory
  • Radial arm maze
  • Spatial memory
  • Testosterone


The effects of aerobic exercise intensity on memory in older adults.


Keywords

  • BDNF
  • activité physique
  • aging
  • cognition
  • entraînement par intervalles de haute intensité
  • executive functions
  • exercice
  • exercise
  • fonctions exécutives
  • high-intensity interval training
  • memory
  • mémoire
  • physical activity
  • vieillissement


Protective effects of vitamin D on neurophysiologic alterations in brain aging: role of brain-derived neurotrophic factor (BDNF).


Keywords

  • BDNF
  • Brain aging
  • neurophysiologic alterations
  • neuroprotection
  • vitamin D supplementation


Differential Effects of Physical Exercise, Cognitive Training, and Mindfulness Practice on Serum BDNF Levels in Healthy Older Adults: A Randomized Controlled Intervention Study.


MeSH Terms

  • Aged
  • Brain-Derived Neurotrophic Factor
  • Cognition
  • Correlation of Data
  • Exercise
  • Female
  • Healthy Aging
  • Healthy Lifestyle
  • Humans
  • Learning
  • Male
  • Mindfulness
  • Neuropsychological Tests
  • Outcome Assessment, Health Care

Keywords

  • Aging
  • brain-derived neurotrophic factor
  • cognitive training
  • mindfulness
  • physical exercise


Dietary Supplementation with Fish Oil or Conjugated Linoleic Acid Relieves Depression Markers in Mice by Modulation of the Nrf2 Pathway.


MeSH Terms

  • Aging
  • Animals
  • Antidepressive Agents
  • Autoimmunity
  • Biomarkers
  • Brain
  • Brain-Derived Neurotrophic Factor
  • Depression
  • Dietary Supplements
  • Docosahexaenoic Acids
  • Fatty Acid Elongases
  • Fatty Acids
  • Fish Oils
  • Inflammation
  • Linoleic Acids, Conjugated
  • Liver
  • Male
  • Mice, Inbred MRL lpr
  • NF-E2-Related Factor 2
  • Oxidative Stress
  • Stearoyl-CoA Desaturase
  • Tumor Necrosis Factor-alpha

Keywords

  • brain derived neurotrophic factor
  • brain fatty acid profile
  • conjugated linoleic acid
  • depression
  • fish oil
  • nuclear erythroid related factor-2

BGN

Alterations of local functional connectivity in lifespan: A resting-state fMRI study.


Keywords

  • four-dimensional spatial-temporal consistency of local neural activity
  • lifespan
  • local functional connectivity
  • local functional connectivity density
  • resting-state fMRI

BHLHE40

Thyroid hormone induces cellular senescence in prostate cancer cells through induction of DEC1.


MeSH Terms

  • Basic Helix-Loop-Helix Transcription Factors
  • Cell Line, Tumor
  • Cell Proliferation
  • Cellular Senescence
  • Cyclin-Dependent Kinase Inhibitor p15
  • Homeodomain Proteins
  • Humans
  • Male
  • Prostatic Neoplasms
  • Thyroid Hormones

Keywords

  • BHLHE40
  • Cellular senescence
  • DEC1
  • Prostate cancer
  • Thyroid hormone

BLM

[Olmesartan inhibits age-associated migration and invasion of human aortic vascular smooth muscle cells by upregulating miR-3133 axis].


MeSH Terms

  • Cell Movement
  • Cell Proliferation
  • Cells, Cultured
  • Humans
  • Imidazoles
  • Matrix Metalloproteinase 2
  • MicroRNAs
  • Muscle, Smooth, Vascular
  • Myocytes, Smooth Muscle
  • Tetrazoles

Keywords

  • aging
  • invasion
  • microRNA
  • migration
  • olmesartan
  • vascular smooth muscle cells

BMI1

Senescence Induced by BMI1 Inhibition Is a Therapeutic Vulnerability in H3K27M-Mutant DIPG.


Keywords

  • BH3 mimetics
  • BMI1
  • DIPG
  • H3K27M mutant
  • H3WT
  • PTC 028
  • RNAi screen
  • SASP
  • senescence

BMP2

Interleukin-1β-Induced Senescence Promotes Osteoblastic Transition of Vascular Smooth Muscle Cells.


MeSH Terms

  • Adult
  • Aged
  • Aged, 80 and over
  • Female
  • Humans
  • Interleukin-1beta
  • Male
  • Middle Aged
  • Muscle, Smooth, Vascular
  • Osteoblasts

Keywords

  • Interleukin-1β
  • Osteoblastic transition
  • Senescence
  • Vascular calcification

BMP4

Direct reprogramming of human smooth muscle and vascular endothelial cells reveals defects associated with aging and Hutchinson-Gilford progeria syndrome.


Keywords

  • aging
  • direct reprogramming
  • endothelial cell
  • human
  • hutchinson-gilford progeria syndrome
  • medicine
  • mouse
  • smooth muscle cell
  • vascular barrier

BMP7

Downregulation of miR-542-3p promotes osteogenic transition of vascular smooth muscle cells in the aging rat by targeting BMP7.


MeSH Terms

  • Aging
  • Animals
  • Base Sequence
  • Bone Morphogenetic Protein 7
  • Down-Regulation
  • Glycerophosphates
  • MicroRNAs
  • Models, Biological
  • Muscle, Smooth, Vascular
  • Myocytes, Smooth Muscle
  • Osteogenesis
  • Rats

Keywords

  • Aging
  • Mir-542-3p
  • Osteogenic differentiation
  • Vascular smooth muscle cells

BOC

Protein Requirements of Elderly Chinese Adults Are Higher than Current Recommendations.


MeSH Terms

  • Aged
  • Aging
  • Amino Acids
  • Body Weight
  • China
  • Dietary Proteins
  • Energy Intake
  • Energy Metabolism
  • Female
  • Humans
  • Male
  • Nutritional Requirements
  • Oxidation-Reduction
  • Phenylalanine
  • Recommended Dietary Allowances
  • Tyrosine

Keywords

  • indicator amino acid oxidation
  • older adults
  • phenylalanine oxidation
  • protein requirement
  • stable isotope

BPI

High TARC plasma levels confer protection to long living individuals by inducing M2 profile.


Keywords

  • FACS
  • Longevity
  • M2 macrophages
  • Plasma profile
  • TARC


Circulating BPIFB4 Levels Associate With and Influence the Abundance of Reparative Monocytes and Macrophages in Long Living Individuals.


Keywords

  • FACS
  • M2 macrophages
  • immunity
  • longevity
  • patrolling-monocytes
  • plasma

BPIFB4

New Insights for BPIFB4 in Cardiovascular Therapy.


Keywords

  • BPIFB4
  • aging
  • cardiovascular disease


LAV-BPIFB4 associates with reduced frailty in humans and its transfer prevents frailty progression in old mice.


MeSH Terms

  • Aged
  • Aged, 80 and over
  • Aging
  • Animals
  • Female
  • Frailty
  • Gene Expression Regulation
  • Genotype
  • Humans
  • Longevity
  • Male
  • Mice
  • Mice, Inbred C57BL
  • Mice, Transgenic
  • Phosphoproteins
  • Specific Pathogen-Free Organisms

Keywords

  • BPIFB4
  • aging
  • frailty
  • longevity-associated variant-lav
  • survival

BRAF

Conditional reprograming culture conditions facilitate growth of lower grade glioma models.


Keywords

  • BRAFV600E
  • Conditional reprogramming
  • NF1
  • Senescence
  • low grade glioma


Active notch protects MAPK activated melanoma cell lines from MEK inhibitor cobimetinib.


Keywords

  • Cobimetinib (PubChem CID: 16222096)
  • MEK
  • Nirogacestat (PubChem CID:46224413)
  • Notch
  • Senescence
  • Uveal melanoma


Mitochondrial metabolic reprograming via BRAF inhibition ameliorates senescence.


MeSH Terms

  • Cell Proliferation
  • Cells, Cultured
  • Cellular Reprogramming
  • Cellular Senescence
  • Drug Evaluation, Preclinical
  • Humans
  • Mitochondria
  • Proto-Oncogene Proteins B-raf

Keywords

  • BRAF
  • Metabolic reprogramming
  • Mitochondrial function
  • SB590885
  • Senescence

BRD2

Brd2 haploinsufficiency extends lifespan and healthspan in C57B6/J mice.


MeSH Terms

  • Animals
  • Female
  • Fertility
  • Grooming
  • Haploinsufficiency
  • Kidney
  • Longevity
  • Male
  • Mice
  • Mice, Inbred C57BL
  • Transcription Factors

BRD4

Inhibition of BRD4 triggers cellular senescence through suppressing aurora kinases in oesophageal cancer cells.


Keywords

  • BRD4
  • aurora kinase
  • cellular senescence
  • oesophageal cancer


BRD4 contributes to LPS-induced macrophage senescence and promotes progression of atherosclerosis-associated lipid uptake.


Keywords

  • BRD4
  • gene expression
  • inflammation
  • macrophage
  • senescence


BET Proteins Are Required for Transcriptional Activation of the Senescent Islet Cell Secretome in Type 1 Diabetes.


MeSH Terms

  • Animals
  • Cell Cycle Proteins
  • Cellular Senescence
  • Diabetes Mellitus, Type 1
  • Female
  • Humans
  • Insulin-Secreting Cells
  • Islets of Langerhans
  • Mice
  • Mice, Inbred NOD
  • Paracrine Communication
  • Protein Binding
  • Transcription Factors
  • Transcriptional Activation

Keywords

  • BET proteins
  • beta cells
  • senescence and SASP
  • type 1 diabetes

BTK

Amelioration of age-related brain function decline by Bruton's tyrosine kinase inhibition.


Keywords

  • BTK
  • cellular senescence
  • healthspan
  • p53
  • progeria

C2

[Effects of resistance training on mitochondrial function in skeletal muscle of aging rats].


MeSH Terms

  • Aging
  • Animals
  • Male
  • Membrane Potential, Mitochondrial
  • Mitochondria, Muscle
  • Muscle, Skeletal
  • Physical Conditioning, Animal
  • Rats
  • Rats, Sprague-Dawley
  • Resistance Training

Keywords

  • fusion protein 2
  • mitochondria
  • quadriceps
  • rats
  • resistance training


Structural and functional characterization of Solanum lycopersicum phosphatidylinositol 3-kinase C2 domain.


MeSH Terms

  • Animals
  • C2 Domains
  • Lycopersicon esculentum
  • Phosphatidylinositol 3-Kinase
  • Plants, Genetically Modified
  • Protein Binding
  • Tobacco

Keywords

  • C2 domain
  • Membrane binding
  • Phosphatidylinositol 3-kinase
  • Senescence

C3

Inverse association between periumbilical fat and longevity mediated by complement C3 and cardiac structure.


Keywords

  • abdominal obesity
  • cardiac structure
  • complement C3
  • longevity
  • periumbilical fat


Complement C3 deficiency ameliorates aging related changes in the kidney.


MeSH Terms

  • Aging
  • Animals
  • Complement C3
  • Inflammation
  • Kidney
  • Kidney Diseases
  • Male
  • Mice
  • Mice, Inbred C57BL
  • Mice, Knockout

Keywords

  • Complement component 3
  • Kidney disorder
  • Senescence


Reduced sialylation triggers homeostatic synapse and neuronal loss in middle-aged mice.


MeSH Terms

  • Aging
  • Animals
  • Brain
  • Homeostasis
  • Immunity, Innate
  • Mice, Transgenic
  • Neurons
  • Racemases and Epimerases
  • Sialic Acid Binding Immunoglobulin-like Lectins
  • Sialic Acids
  • Synapses

Keywords

  • Aging
  • GNE
  • Glycocalyx
  • Microglia
  • Neurodegeneration
  • Neuroinflammation
  • Sialic acid


[Comparative analysis of experimental data about the effects of various polyphenols on lifespan and aging.]


MeSH Terms

  • Animals
  • Antioxidants
  • Female
  • Longevity
  • Male
  • Mice
  • Mice, Inbred BALB C
  • Polyphenols
  • Survival Analysis

Keywords

  • BP-C3
  • Gompertz model
  • SkQ1
  • aging
  • herbal extracts
  • lifespan
  • metformin
  • polyphenols
  • resveratrol
  • tocopherol

C5

The C5-75 Program: Meeting the Need for Efficient, Pragmatic Frailty Screening and Management in Primary Care.


Keywords

  • aging
  • case-finding
  • co-morbid conditions
  • comorbidité
  • dépistage
  • fragilité
  • frailty
  • primary care
  • recherche de cas
  • screening
  • soins de première ligne
  • vieillissement


Can a relatively large spinal cord for the dural sac influence severity of paralysis in elderly patients with cervical spinal cord injury caused by minor trauma?


MeSH Terms

  • Aged
  • Aged, 80 and over
  • Cervical Vertebrae
  • Female
  • Geriatrics
  • Humans
  • Japan
  • Magnetic Resonance Imaging
  • Male
  • Paralysis
  • Severity of Illness Index
  • Spinal Canal
  • Spinal Cord
  • Spinal Cord Injuries
  • Tomography, X-Ray Computed
  • Wounds and Injuries

C6

Evolution of the Aroma of Treixadura Wines during Bottle Aging.


Keywords

  • bottle aging
  • flavor profile
  • sensory evaluation
  • volatile composition
  • white wine


D-galactose induces senescence of glioblastoma cells through YAP-CDK6 pathway.


Keywords

  • CDK6
  • D-galatose
  • YAP
  • cellular senescence
  • glioblastoma

C7

The Vertebral Artery Convergence to the Cervical Spine in Elders.


MeSH Terms

  • Aged
  • Aged, 80 and over
  • Aging
  • Cervical Vertebrae
  • Computed Tomography Angiography
  • Cross-Sectional Studies
  • Female
  • Humans
  • Male
  • Middle Aged
  • Retrospective Studies
  • Vertebral Artery

Keywords

  • angiography
  • computed tomography
  • osteoarthritis
  • spine
  • vertebral artery
  • aging

C9

C9orf72 in myeloid cells suppresses STING-induced inflammation.


MeSH Terms

  • Aging
  • Amyotrophic Lateral Sclerosis
  • Animals
  • C9orf72 Protein
  • Dendritic Cells
  • Encephalomyelitis, Autoimmune, Experimental
  • Female
  • Humans
  • Inflammation
  • Interferon Type I
  • Membrane Proteins
  • Mice
  • Myeloid Cells
  • Neoplasms
  • T-Lymphocytes


Glycine-alanine dipeptide repeats spread rapidly in a repeat length- and age-dependent manner in the fly brain.


MeSH Terms

  • Aging
  • Alanine
  • Animals
  • Animals, Genetically Modified
  • Brain
  • C9orf72 Protein
  • DNA Repeat Expansion
  • Dipeptides
  • Drosophila
  • Female
  • Glycine

Keywords

  • Ageing
  • C9orf72
  • Dipeptide repeat proteins
  • Drosophila
  • PolyGA
  • Repeat size
  • Spread


Human iPSC-derived astrocytes from ALS patients with mutated C9ORF72 show increased oxidative stress and neurotoxicity.


MeSH Terms

  • Amyotrophic Lateral Sclerosis
  • Animals
  • Astrocytes
  • Biomarkers
  • C9orf72 Protein
  • Cells, Cultured
  • Cellular Reprogramming
  • Cellular Senescence
  • Cerebral Cortex
  • Disease Models, Animal
  • Gene Expression Profiling
  • Glutamic Acid
  • Humans
  • Induced Pluripotent Stem Cells
  • Mice
  • Motor Neurons
  • Mutation
  • Oxidative Stress
  • Proteomics
  • Reactive Oxygen Species

Keywords

  • Amyotrophic lateral sclerosis
  • Astrocytes
  • Neurotoxicity
  • Oxidative stress
  • Senescence
  • iPSC

C9orf72

Carriership of two copies of C9orf72 hexanucleotide repeat intermediate-length alleles is a risk factor for ALS in the Finnish population.


Keywords

  • ALS
  • Aging
  • C9orf72
  • Case-control analysis
  • Intermediate repeats

CA1

The relation between tau pathology and granulovacuolar degeneration of neurons.


Keywords

  • AT8
  • Aging
  • CA1
  • Casein kinase 1δ
  • Congo red
  • Dorsal raphe nucleus
  • Locus coeruleus
  • Neurodegeneration
  • Tau pathology


Memory and dendritic spines loss, and dynamic dendritic spines changes are age-dependent in the rat.


Keywords

  • Aging
  • Hippocampus
  • Locomotor activity
  • Memory and learning
  • Prefrontal cortex
  • Pyramidal neurons
  • dendritic spines


Deregulated expression of a longevity gene, Klotho, in the C9orf72 deletion mice with impaired synaptic plasticity and adult hippocampal neurogenesis.


Keywords

  • Amyotrophic lateral sclerosis (ALS)
  • C9ORF72
  • Dentate gyrus, adult neurogenesis
  • Frontotemporal dementia (FTD)
  • Klotho
  • Long-term depression (LTD)
  • Long-term potentiation (LTP)
  • Longevity


COX5A Plays a Vital Role in Memory Impairment Associated With Brain Aging [i]via[/i] the BDNF/ERK1/2 Signaling Pathway.


Keywords

  • BDNF
  • COX5A
  • ERK1/2
  • brain senescence
  • memory impairment
  • mitochondria


Changes of fat-mass and obesity-associated protein expression in the hippocampus in animal models of high-fat diet-induced obesity and D-galactose-induced aging.


Keywords

  • Aging
  • Fto
  • Hippocampus
  • Mice
  • Obesity


Phenylbutyrate ameliorates prefrontal cortex, hippocampus, and nucleus accumbens neural atrophy as well as synaptophysin and GFAP stress in aging mice.


Keywords

  • aging
  • dendrites
  • hippocampus
  • memory and learning
  • nucleus accumbens
  • prefrontal cortex
  • sodium phenylbutyrate


Heterogeneity in brain distribution of activated microglia and astrocytes in a rat ischemic model of Alzheimer's disease after 2 years of survival.


Keywords

  • Alzheimer’s disease
  • aging
  • brain ischemia
  • glia
  • neuroinflammation


Hippocampal Subregion Transcriptomic Profiles Reflect Strategy Selection during Cognitive Aging.


MeSH Terms

  • Animals
  • Cognitive Aging
  • Dentate Gyrus
  • Hippocampus
  • Maze Learning
  • Rats
  • Rats, Inbred F344
  • Spatial Memory
  • Transcriptome

Keywords

  • aging
  • hippocampus
  • pattern separation
  • reference memory
  • spatial discrimination
  • transcription


Associations between pattern separation and hippocampal subfield structure and function vary along the lifespan: A 7 T imaging study.


MeSH Terms

  • Adult
  • Age Factors
  • Aged
  • Brain Mapping
  • Female
  • Hippocampus
  • Humans
  • Longevity
  • Magnetic Resonance Imaging
  • Male
  • Middle Aged
  • Young Adult


Laminarin Pretreatment Provides Neuroprotection against Forebrain Ischemia/Reperfusion Injury by Reducing Oxidative Stress and Neuroinflammation in Aged Gerbils.


Keywords

  • aging
  • laminarin
  • neuroinflammation
  • neuroprotection
  • oxidative stress
  • transient cerebral ischemia


Age-dependent Alteration in Mitochondrial Dynamics and Autophagy in Hippocampal Neuron of Cannabinoid CB1 Receptor-deficient Mice.


Keywords

  • Aging
  • CB1 receptor
  • Hippocampus
  • Mitochondria
  • Mitophagy


Functional Connectivity of Hippocampal CA3 Predicts Neurocognitive Aging via CA1-Frontal Circuit.


Keywords

  • aging
  • functional connectivity
  • hippocampus
  • spatial memory


Integration of qRT-PCR and Immunohistochemical Techniques for mRNA Expression and Localization of m1AChR in the Brain of Aging Rat.


Keywords

  • Acetylcholine
  • Aging
  • Brain
  • Immunohistochemistry
  • m1AChR
  • qRT-PCR


Role of Eclipta prostrata extract in improving spatial learning and memory deficits in D-galactose-induced aging in rats.


MeSH Terms

  • Aging
  • Animals
  • Behavior, Animal
  • CA1 Region, Hippocampal
  • Catalase
  • Dopamine
  • Eclipta
  • Galactose
  • Gene Expression Regulation, Enzymologic
  • Glutathione Peroxidase
  • Glutathione Reductase
  • Male
  • Memory Disorders
  • Nitric Oxide
  • Nitric Oxide Synthase Type II
  • Norepinephrine
  • Plant Extracts
  • RNA, Messenger
  • Rats
  • Rats, Sprague-Dawley
  • Serotonin
  • Spatial Learning
  • Superoxide Dismutase

Keywords

  • Antioxidants
  • Eclipta
  • Galactose
  • Memory disorders
  • Spatial learning


Differential annualized rates of hippocampal subfields atrophy in aging and future Alzheimer's clinical syndrome.


MeSH Terms

  • Aged
  • Aging
  • Alzheimer Disease
  • Atrophy
  • Cohort Studies
  • Cross-Sectional Studies
  • Dentate Gyrus
  • Female
  • Hippocampus
  • Humans
  • Magnetic Resonance Imaging
  • Male
  • Neuropsychological Tests
  • Risk

Keywords

  • Aging
  • Alzheimer's disease
  • Hippocampal subfields
  • MRI


Rectification of radiotherapy-induced cognitive impairments in aged mice by reconstituted Sca-1 stem cells from young donors.


MeSH Terms

  • Animals
  • Behavior, Animal
  • Cognitive Dysfunction
  • Dendritic Spines
  • Hematopoietic Stem Cell Transplantation
  • Hippocampus
  • Humans
  • Long-Term Potentiation
  • Maze Learning
  • Memory
  • Mice
  • Neurons
  • Radiotherapy
  • Recovery of Function
  • Spinocerebellar Ataxias
  • Treatment Outcome

Keywords

  • Aging
  • Bone marrow stem cells
  • Learning and memory
  • Microglia
  • Radiotherapy


Increasing neurogenesis refines hippocampal activity rejuvenating navigational learning strategies and contextual memory throughout life.


MeSH Terms

  • Aging
  • Animals
  • Cyclin D1
  • Cyclin-Dependent Kinase 4
  • Female
  • Hippocampus
  • Learning
  • Memory
  • Memory Consolidation
  • Mice
  • Mice, Inbred C57BL
  • Neural Stem Cells
  • Neurogenesis


Memory Performance Correlates of Hippocampal Subfield Volume in Mild Cognitive Impairment Subtype.


Keywords

  • aging
  • hippocampus
  • memory
  • mild cognitive impairment
  • neuroimaging
  • subfields


Spermidine protects from age-related synaptic alterations at hippocampal mossy fiber-CA3 synapses.


MeSH Terms

  • Aging
  • Animals
  • CA3 Region, Hippocampal
  • Long-Term Potentiation
  • Mice
  • Mossy Fibers, Hippocampal
  • Spermidine
  • Synaptic Transmission
  • Synaptic Vesicles


Methylene blue inhibits Caspase-6 activity, and reverses Caspase-6-induced cognitive impairment and neuroinflammation in aged mice.


MeSH Terms

  • Aging
  • Animals
  • Caspase 6
  • Caspase Inhibitors
  • Cognitive Dysfunction
  • Female
  • Humans
  • Inflammation
  • Male
  • Methylene Blue
  • Mice
  • Mice, Inbred C57BL
  • Mice, Knockout
  • Mice, Transgenic

Keywords

  • Alzheimer disease
  • Axonal degeneration
  • Caspase-6
  • Caspase-6 inhibitor
  • Hippocampal CA1
  • Hippocampal fibres
  • Methylene blue
  • Synaptic plasticity
  • White matter


Long-term Memory Upscales Volume of Postsynaptic Densities in the Process that Requires Autophosphorylation of αCaMKII.


Keywords

  • CA1 area
  • CaMKII
  • IntelliCages
  • aging
  • dendritic spines
  • memory
  • postsynaptic density


PACAP27 mitigates an age-dependent hippocampal vulnerability to PGJ2-induced spatial learning deficits and neuroinflammation in mice.


Keywords

  • CA1
  • CA3
  • Fluoro-Jade C
  • aging
  • microglia
  • radial arm maze


Inhibition of oxidative stress by testosterone improves synaptic plasticity in senescence accelerated mice.


MeSH Terms

  • Aging
  • Animals
  • Male
  • Mice
  • Neuronal Plasticity
  • Oxidative Stress
  • Random Allocation
  • Receptors, N-Methyl-D-Aspartate
  • Testosterone

Keywords

  • Alzheimer’s disease
  • N-methyl-D-aspartate receptor-1
  • Senescence accelerated mouse
  • Testosterone
  • oxidative stress


Restored presynaptic synaptophysin and cholinergic inputs contribute to the protective effects of physical running on spatial memory in aged mice.


MeSH Terms

  • Aging
  • Animals
  • Cholinergic Neurons
  • Hippocampus
  • Mice
  • Mice, Inbred C57BL
  • Physical Conditioning, Animal
  • Presynaptic Terminals
  • Spatial Memory
  • Synaptophysin

Keywords

  • Aging
  • Cholinergic cells
  • Hippocampus
  • Memory
  • Physical training
  • Presynaptic terminals
  • Synaptophysin


Senescent neurophysiology: Ca signaling from the membrane to the nucleus.


MeSH Terms

  • Aging
  • Animals
  • CA1 Region, Hippocampal
  • Calcium Signaling
  • Cell Nucleus
  • Epigenesis, Genetic
  • Excitatory Postsynaptic Potentials
  • Humans
  • Membrane Potentials
  • Neuronal Plasticity
  • Pyramidal Cells
  • Receptors, N-Methyl-D-Aspartate

Keywords

  • Afterhyperpolarization
  • Aging
  • Epigenetics
  • Hippocampus
  • N-methyl-D-aspartate receptor
  • Synaptic plasticity
  • Transcription

CA2

Maintaining Aging Hippocampal Function with Safe and Feasible Shaking Exercise in SAMP10 Mice.


Keywords

  • Aging
  • Behavior analysis
  • Hippocampus
  • Shaking exercise
  • Spatial cognition


One-year Follow-up Study of Hippocampal Subfield Atrophy in Alzheimer's Disease and Normal Aging.


MeSH Terms

  • Aged
  • Aged, 80 and over
  • Aging
  • Alzheimer Disease
  • Atrophy
  • Case-Control Studies
  • Cognitive Dysfunction
  • Disease Progression
  • Female
  • Follow-Up Studies
  • Hippocampus
  • Humans
  • Magnetic Resonance Imaging
  • Male
  • Neuroimaging

Keywords

  • Alzheimer's disease
  • biomarker
  • hippocampal
  • mild cognitive impairment
  • neurodegenerative diseases
  • normal aging
  • radial distance
  • subfield atrophy


Maturation of PNN and ErbB4 Signaling in Area CA2 during Adolescence Underlies the Emergence of PV Interneuron Plasticity and Social Memory.


MeSH Terms

  • Aging
  • Animals
  • Animals, Newborn
  • CA2 Region, Hippocampal
  • Interneurons
  • Long-Term Synaptic Depression
  • Male
  • Memory
  • Mice
  • Mice, Inbred C57BL
  • Neural Inhibition
  • Neuregulin-1
  • Neuronal Plasticity
  • Parvalbumins
  • Receptor, ErbB-4
  • Receptors, Opioid, delta
  • Signal Transduction
  • Social Behavior
  • Synapses
  • gamma-Aminobutyric Acid

Keywords

  • ErbB4
  • adolescence
  • area CA2
  • delta opioid receptors
  • hippocampus
  • long-term depression
  • neuregulin 1
  • parvalbumin interneuron
  • perineuronal net
  • social memory

CA3

Features of Postnatal Hippocampal Development in a Rat Model of Sporadic Alzheimer's Disease.


Keywords

  • Alzheimer’s disease
  • OXYS rats
  • aging
  • hippocampal mossy fibers
  • hippocampus
  • neurogenesis
  • postnatal development


Age-Related Changes in Synaptic Plasticity Associated with Mossy Fiber Terminal Integration during Adult Neurogenesis.


Keywords

  • aging
  • conditional transgenic
  • giant synapse
  • stratum lucidum
  • synaptogenesis


Metabotropic Glutamate Receptors at the Aged Mossy Fiber - CA3 Synapse of the Hippocampus.


Keywords

  • aging
  • hippocampal area CA3
  • mGluRs
  • mossy fibers
  • synaptic transmission

CACNA1S

Increased calcium channel in the lamina propria of aging rat.


MeSH Terms

  • Aging
  • Animals
  • Calcium Channel Blockers
  • Calcium Channels
  • Cell Line
  • Fibroblasts
  • Gene Expression Regulation
  • Humans
  • Larynx
  • Male
  • Mucous Membrane
  • Rats
  • Rats, Sprague-Dawley
  • Verapamil

Keywords

  • aging
  • calcium channel
  • extracellular matrix
  • vocal fold

CAD

Serum soluble Klotho is inversely related to coronary artery calcification assessed by intravascular ultrasound in patients with stable coronary artery disease.


Keywords

  • Aging
  • Coronary artery calcification
  • Intravascular ultrasound
  • Klotho


Shear bond strengths of aged and non-aged CAD/CAM materials after different surface treatments.


Keywords

  • Bond strength
  • Computer-aided design and computer-aided manufacturing (CAD/CAM)
  • Laser
  • Repair
  • Surface treatment
  • Thermal aging


Prediction of Early Postoperative Major Cardiac Events and In-Hospital Mortality in Elderly Hip Fracture Patients: The Role of Different Types of Preoperative Cardiac Abnormalities on Echocardiography Report.


MeSH Terms

  • Aged
  • Aortic Valve Stenosis
  • Cardiovascular Diseases
  • Comorbidity
  • Echocardiography
  • Female
  • Fracture Fixation
  • Hip Fractures
  • Hospital Mortality
  • Humans
  • Male
  • Postoperative Complications
  • Prognosis
  • Risk Factors

Keywords

  • aging
  • echocardiographic abnormality
  • hip fracture surgery
  • mortality
  • postoperative cardiac complications


[Polymorbidity in elderly patients needing myocardial revascularization (a review article).]


MeSH Terms

  • Aged
  • Cognitive Dysfunction
  • Coronary Artery Disease
  • Humans
  • Myocardial Revascularization
  • Quality of Life
  • Risk

Keywords

  • aging
  • elderly
  • ischemic heart disease
  • myocardial revascularization
  • polymorbidity


Fracture force of CAD/CAM resin composite crowns after in vitro aging.


MeSH Terms

  • Ceramics
  • Composite Resins
  • Computer-Aided Design
  • Crowns
  • Dental Porcelain
  • Dental Restoration Failure
  • Dental Stress Analysis
  • Humans
  • Materials Testing

Keywords

  • Aging
  • CAD/CAM
  • CAD/CAM bloc
  • Dental material
  • Fit
  • Preparation
  • Resin composite
  • Resin-based material
  • Storage
  • TCML


Clinical performance of chairside monolithic lithium disilicate glass-ceramic CAD-CAM crowns.


MeSH Terms

  • Ceramics
  • Computer-Aided Design
  • Crowns
  • Dental Porcelain
  • Dental Prosthesis Design
  • Humans
  • Materials Testing

Keywords

  • CAD-CAM
  • chairside
  • dental crowns
  • lithium disilicate
  • longevity
  • survival


Acute resveratrol supplementation in coronary artery disease: towards patient stratification.


MeSH Terms

  • Aged
  • Biomarkers
  • Brachial Artery
  • Cardiac Rehabilitation
  • Coronary Artery Bypass
  • Coronary Artery Disease
  • Cross-Over Studies
  • Exercise Therapy
  • Female
  • Humans
  • Kinetics
  • Male
  • Middle Aged
  • Oxygen
  • Oxygen Consumption
  • Percutaneous Coronary Intervention
  • Resveratrol
  • Single-Blind Method
  • Treatment Outcome
  • Vasodilation

Keywords

  • Antioxidant
  • aging
  • endothelial dysfunction
  • oxygen uptake

CARM1

CARM1 regulates senescence during airway epithelial cell injury in COPD pathogenesis.


MeSH Terms

  • Aged
  • Animals
  • Apoptosis
  • Cell Differentiation
  • Cell Proliferation
  • Cellular Senescence
  • Epithelial Cells
  • Female
  • Humans
  • Male
  • Mice, Inbred C57BL
  • Mice, Knockout
  • Middle Aged
  • Naphthalenes
  • Protein-Arginine N-Methyltransferases
  • Pulmonary Disease, Chronic Obstructive
  • Respiratory Mucosa
  • Wound Healing

Keywords

  • CARM1
  • COPD
  • airway epithelium
  • senescence

CASP3

Does cartilage ERα overexpression correlate with osteoarthritic chondrosenescence? Indications from [i]Labisia pumila[/i] OA mitigation.


MeSH Terms

  • Aging
  • Animals
  • Bone Development
  • Cartilage
  • Chondrocytes
  • Diclofenac
  • Disease Models, Animal
  • Estrogen Receptor alpha
  • Flavonoids
  • Gallic Acid
  • Gene Expression Regulation
  • Humans
  • Iodoacetates
  • Matrix Metalloproteinase 13
  • Metabolism
  • Osteoarthritis
  • Ovariectomy
  • Plant Extracts
  • Primulaceae
  • Rats

CAT

Training improves the handling of inhaler devices and reduces the severity of symptoms in geriatric patients suffering from chronic-obstructive pulmonary disease.


Keywords

  • Chronic-obstructive pulmonary disease - Inhaler devices
  • Compliance
  • Geriatrics


7-chloro-4-(phenylselanyl) quinoline co-treatment prevent oxidative stress in diabetic-like phenotype induced by hyperglycidic diet in Drosophila melanogaster.


Keywords

  • 4-PSQ
  • 7-chloro-4-(phenylselanyl) quinolone
  • Antioxidant effect
  • Diabetic-like phenotype
  • Hyperglycidic diet
  • Longevity
  • Oxidative stress


Aging influences in the blood-brain barrier permeability and cerebral oxidative stress in sepsis.


Keywords

  • Aging
  • Blood-brain barrier
  • Brain
  • Oxidative stress
  • Sepsis


2 -Deoxy - d-glucose at chronic low dose acts as a caloric restriction mimetic through a mitohormetic induction of ROS in the brain of accelerated senescence model of rat.


Keywords

  • 2-Deoxy- d-glucose
  • Aging
  • Brain
  • CRM
  • Mitohormosis
  • ROS


Ceftriaxone improves senile neurocognition damages induced by D-galactose in mice.


Keywords

  • Aging
  • Ceftriaxone
  • D-galactose
  • Mice
  • Oxidative stress


Ginsenoside Rg1 protects against d-galactose induced fatty liver disease in a mouse model via FOXO1 transcriptional factor.


MeSH Terms

  • Animals
  • Antioxidants
  • Cellular Senescence
  • Disease Models, Animal
  • Fatty Liver
  • Forkhead Box Protein O1
  • Galactose
  • Ginsenosides
  • Lipid Peroxidation
  • Male
  • Medicine, Chinese Traditional
  • Mice
  • Mice, Inbred C57BL
  • Oxidative Stress
  • Protective Agents
  • Transcription Factors

Keywords

  • D-galactose
  • FOXO1
  • Non-alcoholic fatty liver disease
  • Rg1
  • Senescence


Effects of long-term intermittent versus chronic calorie restriction on oxidative stress in a mouse cancer model.


MeSH Terms

  • Aging
  • Animals
  • Antioxidants
  • Caloric Restriction
  • Catalase
  • Erythrocytes
  • Female
  • Glutathione
  • Lipid Peroxidation
  • Malondialdehyde
  • Mammary Neoplasms, Experimental
  • Mice, Inbred C57BL
  • Oxidative Stress
  • Superoxide Dismutase

Keywords

  • MMTV-TGF-α mice
  • breast cancer
  • energy restriction
  • intermittent calorie restriction
  • mammary tumor
  • oxidative stress


The Toxicity of Nonaged and Aged Coated Silver Nanoparticles to Freshwater Alga Raphidocelis subcapitata.


MeSH Terms

  • Aquatic Organisms
  • Chlorophyta
  • Fresh Water
  • Hydrodynamics
  • Lipid Peroxidation
  • Metal Nanoparticles
  • Particle Size
  • Reactive Oxygen Species
  • Silver
  • Static Electricity
  • Toxicity Tests

Keywords

  • Aquatic toxicology
  • Ecotoxicology
  • Environmental fate
  • Heavy metals
  • Nanoparticle aging
  • Nanotoxicology

CBS

Permanent cystathionine-β-Synthase gene knockdown promotes inflammation and oxidative stress in immortalized human adipose-derived mesenchymal stem cells, enhancing their adipogenic capacity.


Keywords

  • Cellular senescence
  • Cystathionine β-synthase
  • Human adipose-derived mesenchymal stem cells
  • Inflammation
  • Oxidative stress and adipogenesis


Cardiovascular phenotype of mice lacking 3-mercaptopyruvate sulfurtransferase.


MeSH Terms

  • Animals
  • Antioxidants
  • Cardiovascular System
  • Cystathionine beta-Synthase
  • Cystathionine gamma-Lyase
  • Gene Expression Regulation, Enzymologic
  • Hydrogen Sulfide
  • Male
  • Mice, Inbred C57BL
  • Mice, Knockout
  • Myocardial Reperfusion Injury
  • Myocytes, Cardiac
  • Nitric Oxide
  • Phenotype
  • Reactive Oxygen Species
  • Sulfurtransferases
  • Vasodilation

Keywords

  • 3-mercaptopyruvate transferase (3-MST)
  • Aging
  • Blood pressure
  • Myocardial infarction
  • Nitric Oxide (NO)
  • Reactive Oxygen Species (ROS)

CBX3

Biological functions of chromobox (CBX) proteins in stem cell self-renewal, lineage-commitment, cancer and development.


Keywords

  • Aging
  • Bone
  • CBX1
  • CBX2
  • CBX3
  • CBX4
  • CBX5
  • CBX6
  • CBX7
  • CBX8
  • Cancer
  • Chromatin
  • Development
  • Epigenetics
  • H3K27me3
  • H3K9me3
  • Lineage-commitment
  • Osteoblast
  • Senescence
  • Stem cell

CCK

Senolytic agent Quercetin ameliorates intervertebral disc degeneration via the Nrf2/NF-κB axis.


Keywords

  • Intervertebral disc degeneration
  • NF-κB pathway
  • Nrf2
  • Quercetin
  • Senescence


Astragalus improve aging bone marrow mesenchymal stem cells (BMSCs) vitality and osteogenesis through VD-FGF23-Klotho axis.


Keywords

  • Astragalus
  • BMSCs
  • VD-FGF23-Klotho axis
  • aging
  • osteogenesis differentiation


Effects of Age on Acute Appetite-Related Responses to Whey-Protein Drinks, Including Energy Intake, Gastric Emptying, Blood Glucose, and Plasma Gut Hormone Concentrations-A Randomized Controlled Trial.


Keywords

  • aging
  • appetite
  • energy intake
  • gastric emptying
  • glucose
  • gut hormones
  • whey protein


Lactose induced redox-dependent senescence and activated Nrf2 pathway.


Keywords

  • Lactose
  • Nrf2
  • ROS
  • cellular senescence
  • oxidative stress


Quercetin Suppresses the Progression of Atherosclerosis by Regulating MST1-Mediated Autophagy in ox-LDL-Induced RAW264.7 Macrophage Foam Cells.


MeSH Terms

  • Adenine
  • Animals
  • Atherosclerosis
  • Autophagy
  • Cell Survival
  • Cellular Senescence
  • Cyclin-Dependent Kinase Inhibitor p16
  • Cyclin-Dependent Kinase Inhibitor p21
  • Disease Progression
  • Foam Cells
  • Hepatocyte Growth Factor
  • Lipid Metabolism
  • Lipoproteins, LDL
  • Mice
  • Proto-Oncogene Proteins
  • Quercetin
  • RAW 264.7 Cells
  • Sirolimus
  • Up-Regulation

Keywords

  • RAW264.7
  • atherosclerosis
  • autophagy
  • quercetin
  • senescence


LncRNA AW112010 Promotes Mitochondrial Biogenesis and Hair Cell Survival: Implications for Age-Related Hearing Loss.


MeSH Terms

  • Adenosine Triphosphate
  • Aging
  • Animals
  • Cell Survival
  • DNA-Binding Proteins
  • Gene Silencing
  • Hair Cells, Auditory
  • Hearing Loss
  • Mice
  • Mitochondria
  • Organelle Biogenesis
  • RNA, Long Noncoding
  • Resveratrol
  • Signal Transduction
  • Transcription Factors


Effects of age on feeding response: Focus on the rostral C1 neuron and its glucoregulatory proteins.


Keywords

  • Aging
  • Catecholaminergic neurons
  • Feeding response
  • Glucoprivation
  • Rostral ventrolateral medulla


Ser-Tyr and Asn-Ala, vasorelaxing dipeptides found by comprehensive screening, reduce blood pressure via different age-dependent mechanisms.


MeSH Terms

  • Aging
  • Amino Acid Sequence
  • Animals
  • Antihypertensive Agents
  • Blood Pressure
  • Cholecystokinin
  • Dipeptides
  • Drug Evaluation, Preclinical
  • Hypertension
  • Male
  • Mesenteric Arteries
  • Nitric Oxide
  • Peptide Library
  • Proglumide
  • Rats
  • Rats, Inbred SHR
  • Receptors, Cholecystokinin
  • Vasodilation
  • Vasodilator Agents

Keywords

  • aging
  • dipeptide library
  • nitric oxide
  • structure-activity relationship
  • vasorelaxation


Fisetin, via CKIP-1/REGγ, limits oxidized LDL-induced lipid accumulation and senescence in RAW264.7 macrophage-derived foam cells.


MeSH Terms

  • Animals
  • Autoantigens
  • Carrier Proteins
  • Cellular Senescence
  • Flavonoids
  • Foam Cells
  • Lipid Metabolism
  • Lipoproteins, LDL
  • Mice
  • Proteasome Endopeptidase Complex
  • RAW 264.7 Cells
  • Signal Transduction

Keywords

  • CKIP-1/REGγ signaling
  • Fisetin
  • Lipid accumulation
  • RAW264.7
  • Senescence

CCL11

CCL-11 or Eotaxin-1: An Immune Marker for Ageing and Accelerated Ageing in Neuro-Psychiatric Disorders.


Keywords

  • Alzheimer’s disease
  • CCL-11
  • aging
  • behaviour
  • biomarkers
  • brain
  • cytokines
  • eotaxin
  • prevention
  • schizophrenia
  • stroke

CCL17

Aging and chronic high-fat feeding negatively affects kidney size, function, and gene expression in CTRP1-deficient mice.


Keywords

  • aging
  • heart
  • kidney
  • metabolism
  • obesity

CCL19

Age-Related Gliosis Promotes Central Nervous System Lymphoma through CCL19-Mediated Tumor Cell Retention.


MeSH Terms

  • Adolescent
  • Adult
  • Aged
  • Aging
  • Animals
  • Astrocytes
  • Blood-Brain Barrier
  • Cell Line, Tumor
  • Central Nervous System Neoplasms
  • Chemokine CCL19
  • Chemokine CXCL12
  • Disease Models, Animal
  • Female
  • Gliosis
  • Humans
  • Intravital Microscopy
  • Lymphoma
  • Male
  • Mice
  • Mice, Transgenic
  • Microscopy, Fluorescence, Multiphoton
  • Middle Aged
  • NF-kappa B
  • Receptors, CCR7
  • Time-Lapse Imaging
  • Young Adult

Keywords

  • CCL19
  • CNSL
  • CXCL12
  • DLBCL
  • PCNSL
  • SCNSL
  • gliosis
  • lymphoma
  • metastasis
  • neuroinflammation

CCL2

β1 Integrin regulates adult lung alveolar epithelial cell inflammation.


MeSH Terms

  • Aging
  • Alveolar Epithelial Cells
  • Animals
  • Cell Adhesion
  • Chemokine CCL2
  • Chemokines
  • Disease Models, Animal
  • Epithelium
  • Integrin beta1
  • Lung
  • Macrophages
  • Mice
  • Mice, Inbred C57BL
  • Mice, Knockout
  • Pneumonia
  • Pulmonary Disease, Chronic Obstructive
  • Receptors, CCR2

Keywords

  • COPD
  • Inflammation
  • Integrins
  • Macrophages
  • Pulmonology

CCL20

p53 and p53-related mediators PAI-1 and IGFBP-3 are downregulated in peripheral blood mononuclear cells of HIV-patients exposed to non-nucleoside reverse transcriptase inhibitors.


Keywords

  • Aging
  • Antiretroviral drugs
  • HIV
  • Inflammation
  • NNRTI
  • Senescence
  • p53

CCL28

Age-related chemokine alterations affect IgA secretion and gut immunity in female mice.


Keywords

  • Aging
  • CCL25
  • CCL28
  • Gut immunity
  • IgA

CCN1

Sodium tanshinone IIA sulfonate restrains fibrogenesis through induction of senescence in mice with induced deep endometriosis.


Keywords

  • Deep endometriosis
  • Fibrogenesis
  • Mouse
  • Senescence
  • Sodium tanshinone IIA sulfonate


Inhibition of cellular communication network factor 1 (CCN1)-driven senescence slows down cartilage inflammaging and osteoarthritis.


Keywords

  • CCN1
  • Cartilage inflammaging
  • Chondrocyte cluster
  • Osteoarthritis
  • Senescence


The senescence-associated matricellular protein CCN1 in plasma of human subjects with idiopathic pulmonary fibrosis.


MeSH Terms

  • Aged
  • Cellular Senescence
  • Cysteine-Rich Protein 61
  • Disease Progression
  • Enzyme-Linked Immunosorbent Assay
  • Female
  • Humans
  • Idiopathic Pulmonary Fibrosis
  • Male
  • Middle Aged
  • Outcome Assessment, Health Care
  • Predictive Value of Tests
  • Survival Rate

Keywords

  • CCN1
  • Cellular senescence
  • Idiopathic pulmonary fibrosis
  • Transplant-free survival

CCN3

CCN3 Signaling Is Differently Regulated in Placental Diseases Preeclampsia and Abnormally Invasive Placenta.


Keywords

  • CCN3
  • abnormally invasive placenta
  • invasion
  • preeclampsia
  • senescence
  • trophoblast


CCN3 (NOV) Drives Degradative Changes in Aging Articular Cartilage.


Keywords

  • CCN3
  • NOV
  • SASP
  • aging
  • cellular communication network factor 3
  • oxidative stress
  • p21
  • p53
  • primary chondrocytes
  • senescence

CCND1

Effects of hydrogen peroxide, doxorubicin and ultraviolet irradiation on senescence of human dental pulp stem cells.


MeSH Terms

  • Cells, Cultured
  • Cellular Senescence
  • Dental Pulp
  • Doxorubicin
  • Humans
  • Hydrogen Peroxide
  • Stem Cells
  • Ultraviolet Rays

Keywords

  • Cell cycle
  • ROS
  • Stress induced senescence
  • Ultraviolet irradiation
  • p21

CCND3

The effect of aging on the biological and immunological characteristics of periodontal ligament stem cells.


Keywords

  • Aging
  • Immunosuppression
  • Osteogenic differentiation
  • Periodontal ligament stem cells
  • Peripheral blood mononuclear cells
  • Tissue engineering

CCR2

Hip Fracture Leads to Transitory Immune Imprint in Older Patients.


Keywords

  • acute stress
  • aging
  • immune response
  • inflammation
  • regulation loop


The CC-chemokine receptor 2 is involved in the control of ovarian folliculogenesis and fertility lifespan in mice.


Keywords

  • Aging
  • CCR2
  • Fertility
  • Follicle
  • Ovary


Deficit of resolution receptor magnifies inflammatory leukocyte directed cardiorenal and endothelial dysfunction with signs of cardiomyopathy of obesity.


Keywords

  • inflammatory macrophage
  • kidney function
  • non-resolving inflammation
  • obesogenic aging


Tet2-mediated clonal hematopoiesis in nonconditioned mice accelerates age-associated cardiac dysfunction.


Keywords

  • Aging
  • Bone marrow transplantation
  • Cardiology
  • Hematopoietic stem cells
  • Macrophages


Inflammation and Ectopic Fat Deposition in the Aging Murine Liver Is Influenced by CCR2.


MeSH Terms

  • Aging
  • Animals
  • Body Weight
  • Chemokine CCL2
  • Disease Models, Animal
  • Female
  • Gene Expression Profiling
  • Inflammation
  • Macrophages
  • Male
  • Mice
  • Mice, Inbred C57BL
  • Non-alcoholic Fatty Liver Disease
  • Organ Size
  • Receptors, CCR2


Klotho-mediated targeting of CCL2 suppresses the induction of colorectal cancer progression by stromal cell senescent microenvironments.


MeSH Terms

  • Aged
  • Cell Line, Tumor
  • Cell Movement
  • Cell Proliferation
  • Cellular Microenvironment
  • Cellular Senescence
  • Chemokine CCL2
  • Colorectal Neoplasms
  • Disease Progression
  • Down-Regulation
  • Doxorubicin
  • Female
  • Glucuronidase
  • Human Umbilical Vein Endothelial Cells
  • Humans
  • Male
  • Middle Aged
  • NF-kappa B
  • Neoplasm Invasiveness
  • Proportional Hazards Models
  • Signal Transduction
  • Stromal Cells

Keywords

  • CCL2
  • Klotho
  • colorectal cancer
  • senescence

CCR3

Low Molecular Weight Hyaluronan Induces an Inflammatory Response in Ovarian Stromal Cells and Impairs Gamete Development In Vitro.


MeSH Terms

  • Aging
  • Animals
  • Extracellular Matrix
  • Female
  • Germ Cells
  • Granulosa Cells
  • Hyaluronan Receptors
  • Hyaluronic Acid
  • Inflammation
  • Mice
  • Mice, Inbred BALB C
  • Mice, Inbred C57BL
  • Molecular Weight
  • Ovary
  • Stromal Cells

Keywords

  • hyaluronan fragments
  • inflammation
  • ovarian biology
  • reproductive aging
  • stroma

CCR5

[Enhancement can do harm].


MeSH Terms

  • Adult
  • Aged
  • CRISPR-Cas Systems
  • China
  • Embryo Research
  • Gene Editing
  • Gene Silencing
  • Genetic Enhancement
  • Genome-Wide Association Study
  • HIV Infections
  • HIV-1
  • Humans
  • Longevity
  • Middle Aged
  • Receptors, CCR5

CCS

Frailty Significantly Associated with a Risk for Mid-term Outcomes in Elderly Chronic Coronary Syndrome Patients: a Prospective Study.


Keywords

  • Aging
  • Canada
  • Confidence Intervals
  • Death
  • Frail Elderly
  • Frailty
  • Heart
  • Multivariate Analysis
  • Prognosis
  • Risk Factors


Microbleeds and Medial Temporal Atrophy Determine Cognitive Trajectories in Normal Aging: A Longitudinal PET-MRI Study.


Keywords

  • Atrophy
  • cognition
  • imaging markers
  • medial temporal lobe
  • microbleeds
  • normal aging


Hippocampal Volume Loss, Brain Amyloid Accumulation, and APOE Status in Cognitively Intact Elderly Subjects.


MeSH Terms

  • Aged
  • Aged, 80 and over
  • Amyloid beta-Peptides
  • Apolipoprotein E4
  • Brain
  • Cognitive Aging
  • Female
  • Hippocampus
  • Humans
  • Longitudinal Studies
  • Magnetic Resonance Imaging
  • Male
  • Positron-Emission Tomography

Keywords

  • APOE
  • Aging
  • Amyloid
  • Hippocampus


Amyloid Load, Hippocampal Volume Loss, and Diffusion Tensor Imaging Changes in Early Phases of Brain Aging.


Keywords

  • APOE genotyping
  • amyloid deposition
  • magnetic resonance imaging
  • normal aging
  • positron emission tomography


Lower bone mass is associated with subclinical atherosclerosis, endothelial dysfunction and carotid thickness in the very elderly.


Keywords

  • Aging
  • Endothelial dysfunction
  • Osteoporosis
  • Subclinical atherosclerosis

CD14

Human innate immune cell crosstalk induces melanoma cell senescence.


Keywords

  • NK cell
  • cytokines
  • melanoma
  • senescence
  • slanMo


Fusion Potential of Human Osteoclasts In Vitro Reflects Age, Menopause, and In Vivo Bone Resorption Levels of Their Donors-A Possible Involvement of DC-STAMP.


Keywords

  • CTX
  • DC-STAMP
  • DNA methylation
  • aging
  • cell fusion
  • epigenetics
  • menopause
  • multinucleation
  • osteoclast
  • osteoclastogenesis


Association of CD14 with incident dementia and markers of brain aging and injury.


MeSH Terms

  • Aged
  • Aged, 80 and over
  • Aging
  • Atrophy
  • Biomarkers
  • Brain
  • Cognitive Dysfunction
  • Dementia
  • Female
  • Humans
  • Incidence
  • Lipopolysaccharide Receptors
  • Longitudinal Studies
  • Male
  • Middle Aged


Compromised Bone Healing in Aged Rats Is Associated With Impaired M2 Macrophage Function.


MeSH Terms

  • Age Factors
  • Aging
  • Animals
  • Antigens, CD
  • Antigens, Differentiation, Myelomonocytic
  • Biomarkers
  • Bone Regeneration
  • Bone and Bones
  • Female
  • Fractures, Bone
  • Gene Expression
  • Lipopolysaccharide Receptors
  • Macrophages
  • Osteotomy
  • Rats, Sprague-Dawley
  • Wound Healing

Keywords

  • CD14+ cells
  • aging
  • angiogenesis
  • bone regeneration
  • compromised healing
  • macrophage
  • monocyte

CD19

Sequential treatment with aT19 cells generates memory CAR-T cells and prolongs the lifespan of Raji-B-NDG mice.


MeSH Terms

  • Animals
  • Antigens, CD19
  • Cell Line, Tumor
  • Combined Modality Therapy
  • Disease-Free Survival
  • HEK293 Cells
  • Healthy Volunteers
  • Humans
  • Immunologic Memory
  • Immunotherapy, Adoptive
  • Longevity
  • Lymphoma, B-Cell
  • Mice
  • Neoplasm Recurrence, Local
  • Receptors, Chimeric Antigen
  • Recombinant Proteins
  • Remission Induction
  • T-Lymphocytes
  • Time Factors
  • Transduction, Genetic
  • Transplantation, Autologous
  • Xenograft Model Antitumor Assays

Keywords

  • Autologous CD19 T cells
  • Chimeric antigen receptor
  • Memory T cells
  • Sequential therapy

CD27

The Interplay between CD27 and CD27 B Cells Ensures the Flexibility, Stability, and Resilience of Human B Cell Memory.


Keywords

  • CD27
  • VH repertoire
  • aging
  • germinal center
  • immunodeficiency
  • immunological memory
  • memory B cells
  • pregnancy
  • spleen
  • vaccine


CMV-independent increase in CD27-CD28+ CD8+ EMRA T cells is inversely related to mortality in octogenarians.


Keywords

  • Biomarkers
  • Senescence


Compartmentalized cytotoxic immune response leads to distinct pathogenic roles of natural killer and senescent CD8 T cells in human cutaneous leishmaniasis.


MeSH Terms

  • CD56 Antigen
  • CD57 Antigens
  • Case-Control Studies
  • Cellular Senescence
  • Cytotoxicity, Immunologic
  • Female
  • Gene Expression Regulation
  • Host-Parasite Interactions
  • Humans
  • Interferon-gamma
  • Killer Cells, Natural
  • Lectins, C-Type
  • Leishmania braziliensis
  • Leishmaniasis, Cutaneous
  • Male
  • Oligosaccharides
  • Receptors, Immunologic
  • Severity of Illness Index
  • Sialyl Lewis X Antigen
  • Signal Transduction
  • Skin
  • T-Lymphocytes, Cytotoxic

Keywords

Leishmania braziliensis

  • CD8+ T cells
  • cellular senescence
  • cutaneous leishmaniasis
  • immunopathology
  • natural killer cells


CD27- IgD- B cell memory subset associates with inflammation and frailty in elderly individuals but only in males.


Keywords

  • Aging
  • B cell
  • Frailty
  • Immunosenescence

CD28

Premature CD4 T Cells Senescence Induced by Chronic Infection in Patients with Acute Coronary Syndrome.


Keywords

  • CD28null T cells
  • CD4+ T cells
  • acute coronary syndrome
  • immunosenescence
  • infection


The IMMENSE Study: The Interplay Between iMMune and ENdothelial Cells in Mediating Cardiovascular Risk in Systemic Lupus Erythematosus.


Keywords

  • angiogenic T cells
  • cardiovascular risk
  • endothelial progenitor cells
  • immunosenescence
  • systemic lupus erythematosus


Emergence of T cell immunosenescence in diabetic chronic kidney disease.


Keywords

  • BMI
  • CKD
  • Diabetes
  • Immunosenescence
  • T cell


The relationship between Chlamydia pneumoniae infection and CD4/CD8 ratio, lymphocyte subsets in middle-aged and elderly individuals.


Keywords

  • CD4/CD8 ratio
  • Chlamydia pneumoniae
  • Immune profile
  • Immunosenescence
  • Lymphocyte subsets


Next steps in mechanisms of inflammaging.


Keywords

  • Aging
  • autophagy
  • glutathione
  • membrane potential
  • mitochondria
  • oxidative stress


A randomized pilot trial to evaluate the benefit of the concomitant use of atorvastatin and Raltegravir on immunological markers in protease-inhibitor-treated subjects living with HIV.


MeSH Terms

  • Adult
  • Anti-HIV Agents
  • Anticholesteremic Agents
  • Atorvastatin
  • CD4-Positive T-Lymphocytes
  • CD8-Positive T-Lymphocytes
  • Female
  • HIV Infections
  • HIV Protease Inhibitors
  • Humans
  • Immunosenescence
  • Inflammation
  • Lymphocyte Activation
  • Male
  • Middle Aged
  • Pilot Projects
  • Raltegravir Potassium


Aging affects responsiveness of peripheral blood mononuclear cells to immunosuppression of periodontal ligament stem cells.


Keywords

  • Periodontal ligament stem cells
  • T lymphocytes
  • age
  • coculture
  • cytokines
  • immunophenotyping
  • immunosenescence
  • immunosuppression
  • peripheral blood mononuclear cells


Comparison of Donepezil, Memantine, Melatonin, and Liuwei Dihuang Decoction on Behavioral and Immune Endocrine Responses of Aged Senescence-Accelerated Mouse Resistant 1 Mice.


Keywords

  • Liuwei Dihuang decoction
  • aging
  • cognition
  • immune response
  • inflammation


Immunosenescent characteristics of T cells in young patients following haploidentical haematopoietic stem cell transplantation from parental donors.


Keywords

  • CD28− T cells
  • HaploSCT
  • immune monitoring
  • immunosenescence
  • telomere length


Diagnosis-independent loss of T-cell costimulatory molecules in individuals with cytomegalovirus infection.


Keywords

  • Biological aging
  • Cytomegalovirus
  • Depression
  • Immunosenescence
  • Major depressive disorder
  • Sex differences
  • T-cells


Accelerated immunosenescence in rheumatoid arthritis: impact on clinical progression.


Keywords

  • Ageing
  • Cell senescence
  • Cognitive impairment
  • Immune ageing
  • Rheumatoid arthritis


Accelerated immune aging was correlated with lupus-associated brain fog in reproductive-age systemic lupus erythematosus patients.


Keywords

  • immunosenescence
  • lupus-associated brain fog
  • systemic lupus erythematosus


T cells, aging and senescence.


Keywords

  • Aging
  • Senescence
  • T cells


Liver fibrosis and accelerated immune dysfunction (immunosenescence) among HIV-infected Russians with heavy alcohol consumption - an observational cross-sectional study.


MeSH Terms

  • Adult
  • Alcoholism
  • CD28 Antigens
  • CD4-Positive T-Lymphocytes
  • CD57 Antigens
  • CD8-Positive T-Lymphocytes
  • Cross-Sectional Studies
  • Female
  • HIV Infections
  • Hepatitis C
  • Humans
  • Immunologic Memory
  • Immunosenescence
  • Leukocyte Common Antigens
  • Linear Models
  • Liver Cirrhosis, Alcoholic
  • Male
  • Phenotype
  • Randomized Controlled Trials as Topic
  • Russia
  • Zinc

Keywords

  • Alcohol
  • HIV
  • Immune senescence
  • Liver fibrosis
  • Russia


Effect of Allogenic Bone Marrow Mesenchymal Stem Cell Transplantation on T Cells of Old Mice.


Keywords

  • aging
  • cellular senescence
  • memory T cells
  • stem cell


Peripheral antibody concentrations are associated with highly differentiated T cells and inflammatory processes in the human bone marrow.


Keywords

  • Aging
  • Antibodies
  • B cells
  • Bone marrow
  • Exhaustion
  • Immunosenescence
  • Inflammation
  • Pro-inflammatory
  • Senescence

CD33

Maximum reproductive lifespan correlates with CD33rSIGLEC gene number: Implications for NADPH oxidase-derived reactive oxygen species in aging.


MeSH Terms

  • Animals
  • Gene Dosage
  • Humans
  • Longevity
  • NADPH Oxidases
  • Neutrophils
  • Reactive Oxygen Species
  • Sialic Acid Binding Ig-like Lectin 3
  • Whale, Killer

Keywords

CD33rSIGLEC

  • NADPH-oxidase
  • prolonged post-reproductive lifespan
  • reactive oxygen species

CD34

Comparing the Effect of TGF-β Receptor Inhibition on Human Perivascular Mesenchymal Stromal Cells Derived from Endometrium, Bone Marrow and Adipose Tissues.


Keywords

  • SUSD2
  • adipose tissue
  • apoptosis
  • bone marrow
  • clonogenicity
  • endometrium
  • menstrual fluid
  • perivascular mesenchymal stromal cells
  • placenta
  • senescence


ACE2/ACE imbalance and impaired vasoreparative functions of stem/progenitor cells in aging.


Keywords

  • ACE2
  • Aging
  • Angiotensin-(1-7)
  • Hematopoietic stem/progenitor cells
  • Ischemia


Innovative Mind-Body Intervention Day Easy Exercise Increases Peripheral Blood CD34 Cells in Adults.


Keywords

  • CD34+ cells
  • aging
  • day easy exercise
  • mind–body intervention


Human Thymic Involution and Aging in Humanized Mice.


Keywords

  • aging
  • human
  • humanized mouse
  • recent thymic emigrants
  • thymus involution


Coinhibition of activated p38 MAPKα and mTORC1 potentiates stemness maintenance of HSCs from SR1-expanded human cord blood CD34 cells via inhibition of senescence.


Keywords

  • HSC stemness maintenance
  • Stem Regenin 1
  • cellular senescence
  • ex vivo expansion
  • human cord blood CD34+ cells
  • mammalian target of rapamycin complex 1
  • p38 mitogen-activated protein kinase α


Bulk and single-cell gene expression analyses reveal aging human choriocapillaris has pro-inflammatory phenotype.


MeSH Terms

  • Age Factors
  • Aged
  • Aged, 80 and over
  • Aging
  • Choroid
  • Endothelial Cells
  • Female
  • Gene Expression Regulation
  • Humans
  • Infant
  • Infant, Newborn
  • Inflammation
  • Inflammation Mediators
  • Macular Degeneration
  • Male
  • Middle Aged
  • Phenotype
  • Sequence Analysis, RNA
  • Single-Cell Analysis

Keywords

  • Age-related macular degeneration
  • Choriocapillaris
  • Choroid
  • Infant
  • Pericytes
  • Single-cell


Mesenchymal stem cells repair bone marrow damage of aging rats and regulate autophagy and aging genes.


Keywords

  • aging
  • autophagy
  • bone marrow injury
  • mesenchymal stem cells
  • repair


Immune cell extracellular vesicles and their mitochondrial content decline with ageing.


Keywords

  • Ageing
  • Apoptotic bodies
  • Exosomes
  • Extracellular vesicles
  • Immune cells
  • Immunosenescence
  • Inflammageing
  • Microvesicles
  • Mitochondria


Young and elderly oral squamous cell carcinoma patients present similar angiogenic profile and predominance of M2 macrophages: Comparative immunohistochemical study.


MeSH Terms

  • Adult
  • Aged
  • Aged, 80 and over
  • Antigens, CD
  • Antigens, Differentiation, Myelomonocytic
  • Carcinoma, Squamous Cell
  • Female
  • Humans
  • Immunohistochemistry
  • Immunosenescence
  • Macrophages
  • Male
  • Middle Aged
  • Mouth Neoplasms
  • Neovascularization, Pathologic
  • Receptors, Cell Surface
  • Tumor Microenvironment

Keywords

  • M1 and M2 macrophages
  • angiogenesis
  • immunohistochemistry
  • immunosenescence
  • oral squamous cell carcinoma

CD36

Liver osteopontin is required to prevent the progression of age-related nonalcoholic fatty liver disease.


Keywords

  • Osteopontin
  • aging
  • lipid metabolism
  • nonalcoholic fatty liver disease
  • p53
  • senescence


Reduction of senescence-associated beta-galactosidase activity by vitamin E in human fibroblasts depends on subjects' age and cell passage number.


Keywords

  • CD36 scavenger receptor
  • alpha-tocopherol
  • exosomes
  • extracellular vesicles
  • gene expression
  • lysosome
  • senescence
  • signal transduction
  • vitamin E


Niacin-mediated rejuvenation of macrophage/microglia enhances remyelination of the aging central nervous system.


Keywords

  • Aging
  • Macrophages
  • Microglia
  • Oligodendrocyte progenitor cells
  • Phagocytosis
  • Remyelination

CD38

Re-equilibration of imbalanced NAD metabolism ameliorates the impact of telomere dysfunction.


Keywords

  • CD38 NADase
  • NAD metabolism
  • mitochondrial impairment
  • replicative senescence
  • telomere biology disorders


TNFRSF12A and CD38 Contribute to a Vicious Circle for Chronic Obstructive Pulmonary Disease by Engaging Senescence Pathways.


Keywords

  • aging
  • chronic inflammation
  • lung
  • network analysis
  • senescence
  • tissue remodeling


Aging alters acetylation status in skeletal and cardiac muscles.


Keywords

  • Aging
  • CD38
  • Deacetylation
  • NAD+
  • PARP
  • SIRT
  • Skeletal muscle


CD38 in Neurodegeneration and Neuroinflammation.


Keywords

  • ALS.
  • Alzheimer’s disease
  • CD38
  • NAD
  • Parkinson’s disease
  • aging
  • neurodegeneration
  • neuroinflammation


CD38, a Receptor with Multifunctional Activities: From Modulatory Functions on Regulatory Cell Subsets and Extracellular Vesicles, to a Target for Therapeutic Strategies.


MeSH Terms

  • ADP-ribosyl Cyclase 1
  • Aging
  • Animals
  • Antibodies, Monoclonal
  • B-Lymphocytes, Regulatory
  • Cell Line
  • Extracellular Vesicles
  • Humans
  • Infections
  • Membrane Glycoproteins
  • Mice
  • Neoplasms
  • T-Lymphocytes, Regulatory

Keywords

  • CD38
  • adenosine
  • immune-modulation
  • regulatory cells


CD38 Deficiency Alleviates D-Galactose-Induced Myocardial Cell Senescence Through NAD /Sirt1 Signaling Pathway.


Keywords

  • CD38
  • D-galactose
  • NAD+
  • heart senescence
  • oxidative stress

CD4

Identification of Key Genes and Potential New Biomarkers for Ovarian Aging: A Study Based on RNA-Sequencing Data.


Keywords

  • GEO database
  • bioinformatics
  • biomarker
  • immune cell infiltration
  • ovarian aging


Distinct Age-Related Epigenetic Signatures in CD4 and CD8 T Cells.


Keywords

  • T-cell
  • T-cell homeostasis
  • aging
  • chromatin accessibility
  • epigenetics
  • ribosomal proteins


IL-1β-MyD88-mTOR Axis Promotes Immune-Protective IL-17A Foxp3 Cells During Mucosal Infection and Is Dysregulated With Aging.


Keywords

  • Candida
  • Foxp3
  • IL-1β
  • Treg
  • Treg17
  • aging
  • fungal infection
  • senescence


Thymus involution sets the clock of declined immunity and repair with aging.


Keywords

  • Aging
  • Chronic systemic inflammation
  • Dysregulated CD4 T cells
  • Immune-mediated repair
  • Thymus


Food insecurity and T-cell dysregulation in women living with HIV on antiretroviral therapy.


Keywords

  • HIV
  • exhaustion
  • food insecurity
  • immune activation
  • senescence


Rapamycin Eyedrops Increased CD4 Foxp3 Cells and Prevented Goblet Cell Loss in the Aged Ocular Surface.


Keywords

  • aging
  • dry eye
  • goblet cell
  • inflammation
  • lacrimal gland
  • ocular surface
  • rapamycin


Antioxidants N-Acetylcysteine and Vitamin C Improve T Cell Commitment to Memory and Long-Term Maintenance of Immunological Memory in Old Mice.


Keywords

  • NAC
  • T cells
  • aging
  • antioxidants
  • immunosenescence
  • vaccination
  • vitamin C


Evolution of comorbidities in people living with HIV between 2004 and 2014: cross-sectional analyses from ANRS CO3 Aquitaine cohort.


Keywords

  • Aging
  • Cardiovascular events
  • Chronic kidney disease
  • Comorbidities
  • HIV


Impact of age on CD4 recovery and viral suppression over time among adults living with HIV who initiated antiretroviral therapy in the African Cohort Study.


Keywords

  • Elders on antiretroviral drugs
  • HIV and aging
  • HIV treatment outcomes
  • Sub-saharan Africa


hPMSCs protects against D-galactose-induced oxidative damage of CD4 T cells through activating Akt-mediated Nrf2 antioxidant signaling.


Keywords

  • Aging
  • CD4+ T cells
  • Nrf2
  • Oxidative stress
  • Senescence-associated secretoryphenotype
  • hPMSC


Substantial gap in primary care: older adults with HIV presenting late to care.


Keywords

  • Aging population
  • HIV
  • Older adults
  • Risk
  • Stigma
  • Testing


Quantitative Digitography Measures Fine Motor Disturbances in Chronically Treated HIV Similar to Parkinson's Disease.


Keywords

  • HIV—human immunodeficiency virus
  • Parkinson’s disease
  • aging
  • fine motor activities
  • motor control


Monocyte and T Cell Immune Phenotypic Profiles Associated With Age Advancement Differ Between People With HIV, Lifestyle-Comparable Controls and Blood Donors.


Keywords

  • HIV
  • T cell
  • aging
  • immune activation
  • immune dysfunction
  • inflammation
  • monocyte


HIV and three dimensions of Wisdom: Association with cognitive function and physical and mental well-being: For: Psychiatry Research.


Keywords

  • Affective
  • Aging
  • Aids
  • Compassion
  • Reflective


CD8 T cells are present at low levels in the white matter with physiological and pathological aging.


Keywords

  • aging
  • neuroscience
  • pathology


Immunotherapy in older patients with cancer.


Keywords

  • Ageing
  • Cancer
  • Elderly
  • Immunosenescence
  • Immunotherapy
  • Old people
  • Oncogeriatry


Multiple genetic programs contribute to CD4 T cell memory differentiation and longevity by maintaining T cell quiescence.


Keywords

  • CD4 T cell
  • Cell longevity
  • Gene
  • Genetic programs
  • Memory T cell
  • Memory cell markers


Conventional Treatment for Multiple Myeloma Drives Premature Aging Phenotypes and Metabolic Dysfunction in T Cells.


Keywords

  • T cell
  • aging
  • autologous stem cell transplant
  • metabolism
  • myeloma


Immunosenescence: the role of age in multiple sclerosis.


Keywords

  • Ageing
  • Envejecimiento
  • Esclerosis múltiple
  • Esclerosis múltiple de comienzo tardío
  • Immunosenescence
  • Inmunosenescencia
  • Late-onset multiple sclerosis
  • Multiple sclerosis


Umbilical cord mesenchymal stem cells protect thymus structure and function in aged C57 mice by downregulating aging-related genes and upregulating autophagy- and anti-oxidative stress-related genes.


Keywords

  • aged
  • senescence
  • thymus
  • transplantation
  • umbilical cord mesenchymal stem cells


Impaired Cytotoxic CD8 T Cell Response in Elderly COVID-19 Patients.


MeSH Terms

  • Aged, 80 and over
  • Antigens, CD
  • Betacoronavirus
  • CD4-Positive T-Lymphocytes
  • CD8-Positive T-Lymphocytes
  • COVID-19
  • Coronavirus Infections
  • Cytotoxins
  • Female
  • Humans
  • Immunity, Cellular
  • Male
  • Middle Aged
  • Pandemics
  • Pneumonia, Viral
  • SARS-CoV-2
  • T-Lymphocyte Subsets
  • T-Lymphocytes, Cytotoxic

Keywords

  • CD4+
  • CD8+
  • COVID-19
  • PD-1
  • SARS-CoV-2
  • aging
  • cytotoxic T cells
  • granzyme
  • perforin


What are the roles of antibodies versus a durable, high quality T-cell response in protective immunity against SARS-CoV-2?


Keywords

  • Antibodies
  • Antibody-dependent enhancement
  • CD8 T-cells
  • COVID-19
  • Durable immunity
  • Protective immunity
  • SARS
  • SARS-CoV-2
  • T cell lifespan
  • T-cell epitopes
  • T-cells
  • Vaccines
  • Yellow Fever Vaccine


Per2 Upregulation in Circulating Hematopoietic Progenitor Cells During Chronic HIV Infection.


Keywords

  • HIV
  • Sirtuin 1
  • hematopoietic progenitor cells
  • period circadian clock 2
  • senescence
  • telomere length


COVID-19: age, Interleukin-6, C-reactive protein, and lymphocytes as key clues from a multicentre retrospective study.


Keywords

  • ACE2
  • C-reactive protein
  • COVID-19
  • Immunity
  • Immunosenescence
  • Interleukin-6
  • Lymphocytes
  • Renin-angiotensin system
  • Severe acute respiratory syndrome coronavirus 2
  • Spain


Immunosenescence profiles are not associated with muscle strength, physical performance and sarcopenia risk in very old adults: The Newcastle 85+ Study.


Keywords

  • immunosenescence
  • lymphocyte compartments
  • physical performance
  • sarcopenia
  • very old adults


Homeostasis and the functional roles of CD4 Treg cells in aging.


Keywords

  • Aging
  • Autoimmunity
  • Cancer
  • FOXP3
  • Immune senescence
  • Immune suppression
  • Inflammaging
  • Regulatory T cells
  • T helper 17
  • Treg


A Comprehensive Evaluation of the Impact of Bovine Milk Containing Different Beta-Casein Profiles on Gut Health of Ageing Mice.


Keywords

  • A2 beta-casein
  • SCFAs
  • elderly
  • gut inflammation
  • gut microbiota
  • gut morphology
  • immunosenescence


Premature aging of circulating T cells predicts all-cause mortality in hemodialysis patients.


Keywords

  • Hemodialysis
  • Inflammation
  • Mortality
  • T cell aging
  • naïve T cells


In-depth immune cellular profiling reveals sex-specific associations with frailty.


Keywords

  • Frailty
  • Healthy aging
  • Immune cellular profiling
  • Immune homeostasis
  • Immunosenescence
  • Sex-specific immune profile


CD70 contributes to age-associated T cell defects and overwhelming inflammatory responses.


Keywords

  • CD70
  • T cell aging
  • co-inhibitory molecules
  • immunosenescence
  • overwhelming inflammatory responses


Comparison of Overall and Comorbidity-Free Life Expectancy Between Insured Adults With and Without HIV Infection, 2000-2016.


MeSH Terms

  • Adult
  • Chronic Disease
  • Cohort Studies
  • Comorbidity
  • Female
  • HIV Infections
  • Humans
  • Insurance, Health
  • Life Expectancy
  • Male
  • Middle Aged


Comparative Analysis of Age-Related Changes in Lacrimal Glands and Meibomian Glands of a C57BL/6 Male Mouse Model.


Keywords

  • aging
  • dry eye
  • inflammation
  • lacrimal glands
  • meibomian glands
  • oxidative stress
  • senescence


Thymus aging in mice deficient in either EphB2 or EphB3, two master regulators of thymic epithelium development.


Keywords

  • senescence
  • thymic epithelial cells
  • thymocytes


CD8 T-cell senescence and skewed lymphocyte subsets in young Dyskeratosis Congenita patients with PARN and DKC1 mutations.


Keywords

DKC1

PARN

  • Dyskeratosis Congenita
  • primary immunodeficiency
  • senescence
  • telomere


Short-Term Environmental Enrichment is a Stronger Modulator of Brain Glial Cells and Cervical Lymph Node T Cell Subtypes than Exercise or Combined Exercise and Enrichment.


Keywords

  • Aging
  • Astrocytes
  • Environmental enrichment
  • Microglia
  • Physical exercise
  • T cells


Viral and host factors related to the clinical outcome of COVID-19.


MeSH Terms

  • Adolescent
  • Adult
  • Aged
  • Aged, 80 and over
  • Aging
  • Animals
  • Asymptomatic Infections
  • Betacoronavirus
  • COVID-19
  • China
  • Cohort Studies
  • Coronavirus Infections
  • Critical Illness
  • Disease Progression
  • Evolution, Molecular
  • Female
  • Genetic Variation
  • Genome, Viral
  • Hospitalization
  • Host-Pathogen Interactions
  • Humans
  • Inflammation Mediators
  • Interleukin-6
  • Interleukin-8
  • Lymphocyte Count
  • Lymphopenia
  • Male
  • Middle Aged
  • Pandemics
  • Phylogeny
  • Pneumonia, Viral
  • Respiratory Distress Syndrome
  • SARS-CoV-2
  • T-Lymphocytes
  • Time Factors
  • Treatment Outcome
  • Virulence
  • Virus Shedding
  • Young Adult
  • Zoonoses


Use of comedications and potential drug-drug interactions in people living with HIV in China.


Keywords

  • Aging
  • China
  • Co-medication
  • Drug-drug interaction
  • HIV


CD4 T helper 17 cell response of aged mice promotes prostate cancer cell migration and invasion.


MeSH Terms

  • Aging
  • Animals
  • CD4-Positive T-Lymphocytes
  • Cell Differentiation
  • Cell Line, Tumor
  • Cell Movement
  • Humans
  • Inflammation
  • Male
  • Mice
  • Mice, Inbred C57BL
  • Mice, Knockout
  • Models, Animal
  • NF-kappa B
  • Neoplasm Invasiveness
  • PC-3 Cells
  • Prostatic Neoplasms
  • Th17 Cells

Keywords

  • CD4+ T cell-secreted factors
  • PCa cells
  • Th17 cytokines
  • aging
  • inflammation


The Rules of Human T Cell Fate [i]in vivo[/i].


Keywords

  • decision
  • fate
  • half-life
  • labeling
  • lifespan
  • lymphocyte
  • mathematical model
  • proliferation


CD4/CD8 ratio, comorbidities, and aging in treated HIV infected individuals on viral suppression.


Keywords

  • CD4/CD8 ratio
  • HIV
  • aging
  • comorbidities


The effects of advanced maternal age on T-cell subsets at the maternal-fetal interface prior to term labor and in the offspring: a mouse study.


MeSH Terms

  • Adult
  • Aging
  • Animals
  • Female
  • Humans
  • Live Birth
  • Mice
  • Mice, Transgenic
  • Placenta
  • Pregnancy
  • T-Lymphocyte Subsets

Keywords

  • birth weight
  • neonate
  • offspring
  • pregnancy
  • preterm labor


Structural and Functional Changes in the Mesenteric Lymph Nodes in Humans during Aging.


Keywords

  • age-related involution
  • aging
  • immune system
  • immunomorphology
  • mesenteric lymph nodes


Neurocognitive Functioning is Associated with Self-Reported and Performance-Based Treatment Management Abilities in People Living with HIV with Low Health Literacy.


MeSH Terms

  • Adult
  • Cognition
  • Cross-Sectional Studies
  • HIV Infections
  • Health Literacy
  • Humans
  • Neuropsychological Tests
  • Self Report

Keywords

  • Adherence
  • Aging
  • Cognitive impairment
  • HIV/AIDS
  • Health illiteracy
  • Observational study


Blockade of Stat3 oncogene addiction induces cellular senescence and reveals a cell-nonautonomous activity suitable for cancer immunotherapy.


Keywords

  • Stat3
  • immune checkpoint blockade
  • immunotherapy
  • oncogene addiction
  • senescence


Age-related changes in T lymphocytes of patients with head and neck squamous cell carcinoma.


Keywords

  • Aging
  • Head and neck cancer
  • Immune escape
  • Immunosenescence
  • T cells


Immunological history governs human stem cell memory CD4 heterogeneity via the Wnt signaling pathway.


MeSH Terms

  • Aging
  • Animals
  • Antigens, CD
  • CD4-Positive T-Lymphocytes
  • Gene Expression Profiling
  • HIV Infections
  • Humans
  • Immunologic Memory
  • Intercellular Signaling Peptides and Proteins
  • Mice
  • Precursor Cells, T-Lymphoid
  • Thymus Gland
  • Wnt Signaling Pathway
  • beta Catenin


Estimating HIV Management and Comorbidity Costs Among Aging HIV Patients in the United States: A Systematic Review.


MeSH Terms

  • Anti-HIV Agents
  • CD4 Lymphocyte Count
  • Comorbidity
  • Cost-Benefit Analysis
  • HIV Infections
  • Health Care Costs
  • Humans
  • Life Expectancy
  • United States


Sex Differences in People Aging With HIV.


MeSH Terms

  • Aged
  • Aging
  • Alcohol Drinking
  • Body Composition
  • CD4 Lymphocyte Count
  • CD4-CD8 Ratio
  • CD4-Positive T-Lymphocytes
  • Cohort Studies
  • Cross-Sectional Studies
  • Female
  • Frailty
  • HIV Infections
  • Humans
  • Male
  • Middle Aged
  • Muscle Strength
  • Prospective Studies


Identification of Differentially Expressed miRNAs in the Response of Spleen CD4 T Cells to Electroacupuncture in Senescence-Accelerated Mice.


MeSH Terms

  • Aging
  • Animals
  • Antagomirs
  • CD4-Positive T-Lymphocytes
  • Cell Differentiation
  • Cytokines
  • Down-Regulation
  • Electroacupuncture
  • Female
  • Gene Regulatory Networks
  • High-Throughput Nucleotide Sequencing
  • Male
  • Mice
  • Mice, Inbred C57BL
  • MicroRNAs
  • Sequence Analysis, RNA
  • Spleen
  • Up-Regulation

Keywords

  • CD4+ T cell
  • Deep sequencing
  • Electroacupuncture
  • Immunological aging
  • miRNA


Thymus Involution and Intravenous Drug Abuse.


MeSH Terms

  • Adolescent
  • Adult
  • Aging
  • Atrophy
  • CD4-Positive T-Lymphocytes
  • CD8-Positive T-Lymphocytes
  • Calcinosis
  • Case-Control Studies
  • Drug Users
  • Female
  • Forensic Pathology
  • Hepatitis C, Chronic
  • Humans
  • Male
  • Middle Aged
  • Substance Abuse, Intravenous
  • Thymus Gland
  • Young Adult


Depletion of CD4 T cells provides therapeutic benefits in aged mice after ischemic stroke.


MeSH Terms

  • Aging
  • Animals
  • Behavior, Animal
  • Brain Chemistry
  • Brain Ischemia
  • CD4-Positive T-Lymphocytes
  • Chemokines
  • Cytokines
  • Female
  • Infarction, Middle Cerebral Artery
  • Inflammation
  • Male
  • Mice
  • Mice, Inbred C57BL
  • Stroke
  • Treatment Outcome

Keywords

  • Age
  • CD4 T cells
  • CXCL10
  • Inflammation
  • Stroke


Immunological and Virological Responses in Older HIV-Infected Adults Receiving Antiretroviral Therapy: An Evidence-Based Meta-Analysis.


MeSH Terms

  • Aged
  • Aging
  • Anti-HIV Agents
  • HIV Infections
  • Humans
  • Middle Aged


African Mitochondrial DNA Haplogroup L2 Is Associated With Slower Decline of β-cell Function and Lower Incidence of Diabetes Mellitus in Non-Hispanic, Black Women Living With Human Immunodeficiency Virus.


Keywords

  • HIV
  • aging
  • diabetes mellitus
  • mitochondrial genetics


DP1 Activation Reverses Age-Related Hypertension Via NEDD4L-Mediated T-Bet Degradation in T Cells.


MeSH Terms

  • Aged
  • Aging
  • Animals
  • Antihypertensive Agents
  • CD4-Positive T-Lymphocytes
  • Cyclic AMP-Dependent Protein Kinases
  • Cytokines
  • Humans
  • Hypertension
  • Mice
  • Mice, Inbred C57BL
  • Nedd4 Ubiquitin Protein Ligases
  • Prostaglandin D2
  • Receptors, Prostaglandin
  • Signal Transduction
  • Sp1 Transcription Factor
  • Superoxides
  • T-Box Domain Proteins
  • Th1 Cells
  • Ubiquitination

Keywords

  • D-prostanoid receptor 1
  • aging
  • hypertension
  • lymphocyte
  • prostaglandin (PG) D2


An Emerging Concern-High Rates of Frailty among Middle-aged and Older Individuals Living with HIV.


Keywords

  • accelerated aging
  • anti-retroviral therapy
  • frailty
  • frailty index
  • geriatric syndrome
  • human immunodeficiency virus (HIV)
  • multimorbidity
  • vulnerability


Higher Acuity Resource Utilization With Older Age and Poorer HIV Control in Adolescents and Young Adults in the HIV Research Network.


MeSH Terms

  • Adolescent
  • Adult
  • Aging
  • Anti-Retroviral Agents
  • CD4 Lymphocyte Count
  • Drug Administration Schedule
  • Female
  • HIV Infections
  • HIV-1
  • Humans
  • Male
  • Medication Adherence
  • Viral Load
  • Young Adult


Mitochondrial DNA Haplogroups and Frailty in Adults Living with HIV.


Keywords

  • HIV
  • aging
  • frailty
  • haplotypes
  • mitochondria
  • sarcopenia


Gallic acid attenuates thymic involution in the d-galactose induced accelerated aging mice.


Keywords

  • Aging
  • FoxN1
  • Gallic acid
  • Thymus
  • d-galactose


Mitochondrial mass governs the extent of human T cell senescence.


MeSH Terms

  • Adenosine Triphosphate
  • Adult
  • CD4-Positive T-Lymphocytes
  • CD8-Positive T-Lymphocytes
  • Cell Movement
  • Cell Proliferation
  • Cellular Senescence
  • Glucose
  • Glycolysis
  • Humans
  • Immunosenescence
  • Leukocyte Common Antigens
  • Microscopy, Electron, Transmission
  • Middle Aged
  • Mitochondria
  • Rotenone

Keywords

  • T cell
  • aging
  • metabolism
  • mitochondria
  • senescence


T cells and immune functions of plasma extracellular vesicles are differentially modulated from adults to centenarians.


MeSH Terms

  • Adult
  • Aged
  • Aged, 80 and over
  • Extracellular Vesicles
  • Female
  • Humans
  • Immunosenescence
  • Lymphocyte Activation
  • Male
  • Middle Aged
  • T-Lymphocytes

Keywords

  • T cells
  • aging
  • centenarians
  • extracellular vesicles (EVs)
  • immunosenescence


Defects in Antiviral T Cell Responses Inflicted by Aging-Associated miR-181a Deficiency.


MeSH Terms

  • Aging
  • Animals
  • CD4-Positive T-Lymphocytes
  • CD8-Positive T-Lymphocytes
  • Disease Models, Animal
  • Lymphocytic Choriomeningitis
  • Lymphocytic choriomeningitis virus
  • Mice
  • MicroRNAs

Keywords

  • CD8 effector T cell
  • T cell repertoire
  • antiviral response
  • immune aging
  • immunosenescence
  • microRNA


Increased Prevalence of Neurocognitive Impairment in Aging People Living With Human Immunodeficiency Virus: The ANRS EP58 HAND 55-70 Study.


Keywords

  • Frascati criteria
  • HAND
  • HIV
  • aging
  • neurocognitive impairment


Age-associated changes in human CD4 T cells point to mitochondrial dysfunction consequent to impaired autophagy.


MeSH Terms

  • Adult
  • Aged
  • CD4-Positive T-Lymphocytes
  • Cell Respiration
  • Humans
  • Immunosenescence
  • Longitudinal Studies
  • Mitochondria
  • Mitophagy
  • Young Adult

Keywords

  • CD4+ T cells
  • aging
  • autophagy
  • mitochondria
  • proteomics


Sex Differences in the Blood Transcriptome Identify Robust Changes in Immune Cell Proportions with Aging and Influenza Infection.


MeSH Terms

  • Aging
  • CD4-Positive T-Lymphocytes
  • Female
  • Humans
  • Influenza, Human
  • Male
  • Monocytes
  • Sex Characteristics
  • Transcriptome

Keywords

  • CD4(+) T cells
  • aging
  • immune system
  • immunology
  • influenza
  • meta-analysis
  • monocytes
  • multi-cohort analysis
  • sex differences
  • transcriptome


Going Beyond Giving Antiretroviral Therapy: Multimorbidity in Older People Aging with HIV in Nigeria.


Keywords

  • ART
  • PLWH
  • aging
  • multimorbidity
  • quality of life


Alterations in composition of immune cells and impairment of anti-tumor immune response in aged oral cancer-bearing mice.


MeSH Terms

  • Aged
  • Animals
  • Cell Line, Tumor
  • Cell Proliferation
  • Female
  • Humans
  • Immunotherapy
  • Mice

Keywords

  • Aging
  • Immune check-point molecules
  • Immunosenescence
  • Immunotherapy
  • Myeloid derived suppressor cells
  • Oral cancer
  • Regulatory T cells


LTA1 is a safe, intranasal enterotoxin-based adjuvant that improves vaccine protection against influenza in young, old and B-cell-depleted (μMT) mice.


MeSH Terms

  • Adjuvants, Immunologic
  • Administration, Intranasal
  • Aging
  • Animals
  • Antibodies
  • Antibody Formation
  • B-Lymphocytes
  • CD4-Positive T-Lymphocytes
  • Dose-Response Relationship, Immunologic
  • Enterotoxins
  • Female
  • Immunity, Mucosal
  • Immunization
  • Inflammation
  • Influenza A Virus, H1N1 Subtype
  • Lung
  • Lymphocyte Activation
  • Lymphocyte Depletion
  • Mast Cells
  • Mice, Inbred C57BL
  • Orthomyxoviridae Infections


Thymus Imaging Detection and Size Is Inversely Associated With Metabolic Syndrome and Frailty in People With HIV.


Keywords

  • HIV
  • aging
  • frailty
  • metabolic syndrome
  • thymus


Alterations in peripheral T cell and B cell subsets in patients with osteoarthritis.


MeSH Terms

  • Aged
  • Aging
  • B-Lymphocyte Subsets
  • Case-Control Studies
  • Female
  • Humans
  • Male
  • Middle Aged
  • Osteoarthritis, Knee
  • T-Lymphocyte Subsets

Keywords

  • B cell
  • Lymphocyte
  • Osteoarthritis
  • T cell


Short Communication: Carotid Intima-Media Thickness Is Not Associated with Neurocognitive Impairment Among People Older than 50 Years With and Without HIV Infection from Thailand.


MeSH Terms

  • Aging
  • Anti-Retroviral Agents
  • Cardiovascular Diseases
  • Carotid Intima-Media Thickness
  • Cross-Sectional Studies
  • Depression
  • Female
  • HIV Infections
  • Humans
  • Male
  • Middle Aged
  • Neurocognitive Disorders
  • Quality of Life
  • Risk Factors
  • Thailand

Keywords

  • HIV
  • aging
  • carotid intima-media thickness
  • neurocognitive


Implications of Immune Checkpoint Expression During Aging in HIV-Infected People on Antiretroviral Therapy.


MeSH Terms

  • Adult
  • Aged
  • Aging
  • Anti-HIV Agents
  • Antiretroviral Therapy, Highly Active
  • CD4-Positive T-Lymphocytes
  • CD8-Positive T-Lymphocytes
  • Cytokines
  • Female
  • Flow Cytometry
  • Gene Expression
  • HIV Infections
  • HIV-1
  • Hepatitis A Virus Cellular Receptor 2
  • Humans
  • Leukocytes, Mononuclear
  • Male
  • Middle Aged
  • Young Adult
  • gag Gene Products, Human Immunodeficiency Virus

Keywords

  • aging
  • immune checkpoint molecules
  • virus suppression


Age-related alterations in human gut CD4 T cell phenotype, T helper cell frequencies, and functional responses to enteric bacteria.


MeSH Terms

  • Adolescent
  • Adult
  • Age Factors
  • Aged
  • Aged, 80 and over
  • CD4-Positive T-Lymphocytes
  • Female
  • Gastrointestinal Microbiome
  • Humans
  • Interleukin-17
  • Intestinal Mucosa
  • Male
  • Middle Aged
  • Phenotype
  • Th1 Cells
  • Th17 Cells
  • Young Adult

Keywords

  • T helper cells
  • aging
  • gut
  • human


Determinants of blood telomere length in antiretroviral treatment-naïve HIV-positive participants enrolled in the NEAT 001/ANRS 143 clinical trial.


MeSH Terms

  • Adult
  • Aged
  • Anti-Retroviral Agents
  • Cross-Sectional Studies
  • Darunavir
  • Emtricitabine
  • Female
  • HIV Infections
  • Humans
  • Logistic Models
  • Male
  • Middle Aged
  • RNA, Viral
  • Raltegravir Potassium
  • Ritonavir
  • Telomere
  • Tenofovir

Keywords

  • HIV infection
  • aging
  • immunosenescence
  • telomere length
  • viral load


Human T Cell Differentiation Negatively Regulates Telomerase Expression Resulting in Reduced Activation-Induced Proliferation and Survival.


MeSH Terms

  • Adult
  • Cell Differentiation
  • Cell Proliferation
  • Cell Survival
  • Humans
  • T-Lymphocytes
  • Telomerase

Keywords

  • T cell subsets
  • T lymphocytes
  • aging
  • alternative splicing
  • differentiation
  • hTERT
  • proliferation
  • telomerase


Short Communication: Getting Older with HIV: Increasing Frequency of Comorbidities and Polypharmacy in Brazilian HIV Patients.


MeSH Terms

  • Aged
  • Aging
  • Brazil
  • CD4 Lymphocyte Count
  • Cardiovascular Diseases
  • Comorbidity
  • Diabetes Mellitus
  • Female
  • HIV Infections
  • Humans
  • Life Expectancy
  • Male
  • Middle Aged
  • Neoplasms
  • Polypharmacy

Keywords

  • Brazil
  • HIV
  • aging
  • noncommunicable diseases


Gait Speed Decline Is Associated with Hemoglobin A1C, Neurocognitive Impairment, and Black Race in Persons with HIV.


MeSH Terms

  • Adult
  • African Americans
  • Aging
  • CD4 Lymphocyte Count
  • Cohort Studies
  • Female
  • Glycated Hemoglobin A
  • HIV Infections
  • Humans
  • Longitudinal Studies
  • Male
  • Middle Aged
  • Neurocognitive Disorders
  • Odds Ratio
  • RNA, Viral
  • Risk Factors
  • Walking Speed

Keywords

  • aging
  • gait speed
  • hemoglobin A1C
  • neurocognitive impairment


Noncommunicable Diseases Burden and Risk Factors in a Cohort of HIV+ Elderly Patients in Malawi.


MeSH Terms

  • Adult
  • Age Factors
  • Aged
  • Anti-HIV Agents
  • Anti-Retroviral Agents
  • CD4 Lymphocyte Count
  • Comorbidity
  • Cost of Illness
  • Cross-Sectional Studies
  • Diabetes Mellitus
  • Female
  • HIV Infections
  • Humans
  • Hypertension
  • Malawi
  • Male
  • Middle Aged
  • Noncommunicable Diseases
  • Odds Ratio
  • Prevalence
  • Retrospective Studies
  • Risk Factors

Keywords

  • HIV infection
  • Malawi
  • aging
  • noncommunicable diseases


Aging promotes reorganization of the CD4 T cell landscape toward extreme regulatory and effector phenotypes.


MeSH Terms

  • Aging
  • Animals
  • CD4-Positive T-Lymphocytes
  • High-Throughput Nucleotide Sequencing
  • Immunomodulation
  • Mice
  • Phenotype
  • Sequence Analysis, RNA
  • Single-Cell Analysis
  • T-Lymphocyte Subsets


Prevalence of hypertension and cardiovascular risk factors among long-term AIDS survivors: A report from the field.


MeSH Terms

  • Acquired Immunodeficiency Syndrome
  • Adult
  • Anti-Retroviral Agents
  • CD4 Lymphocyte Count
  • Cardiovascular Diseases
  • Diabetes Mellitus
  • Diagnostic Screening Programs
  • Female
  • HIV Infections
  • HIV-1
  • Haiti
  • Humans
  • Hypercholesterolemia
  • Hypertension
  • Male
  • Middle Aged
  • Obesity
  • Prevalence
  • Retrospective Studies
  • Risk Factors
  • Smoking
  • Survivors

Keywords

  • HIV
  • aging
  • cardiovascular disease
  • hypertension
  • risk assessment

CD44

Hyaluronan goes to great length.


Keywords

  • aging
  • hyaluronan
  • longevity
  • naked mole rat
  • very high molecular weight hyaluronan


Naked mole-rat very-high-molecular-mass hyaluronan exhibits superior cytoprotective properties.


MeSH Terms

  • Animals
  • Apoptosis
  • Cell Cycle Checkpoints
  • Cell Line
  • Cytoprotection
  • Gene Expression Regulation
  • Gene Knockout Techniques
  • Humans
  • Hyaluronan Receptors
  • Hyaluronic Acid
  • Longevity
  • Mice
  • Mole Rats
  • Molecular Weight
  • Primary Cell Culture
  • Protein Interaction Maps
  • RNA-Seq
  • Signal Transduction
  • Species Specificity
  • Stress, Physiological
  • Tumor Suppressor Protein p53


Maturity-dependent cartilage cell plasticity and sensitivity to external perturbation.


Keywords

  • Aging
  • Articular cartilage
  • Osteoarthritis
  • Plasticity
  • Progenitor cells


Aged Mice Exhibit Severe Exacerbations of Dry Eye Disease with an Amplified Memory Th17 Cell Response.


MeSH Terms

  • Aging
  • Animals
  • Dry Eye Syndromes
  • Female
  • Immunologic Memory
  • Mice
  • Mice, Inbred C57BL
  • Th17 Cells


Chronic circadian misalignment accelerates immune senescence and abbreviates lifespan in mice.


MeSH Terms

  • Animals
  • B-Lymphocytes
  • Cellular Senescence
  • Circadian Rhythm
  • Disease Models, Animal
  • Humans
  • Hyaluronan Receptors
  • Inflammation
  • Jet Lag Syndrome
  • Longevity
  • Mice
  • Programmed Cell Death 1 Receptor
  • Sequence Analysis, RNA
  • T-Lymphocytes


Defective induction of the proteasome associated with T-cell receptor signaling underlies T-cell senescence.


MeSH Terms

  • Animals
  • CD4-Positive T-Lymphocytes
  • Cell Proliferation
  • Cells, Cultured
  • Cellular Senescence
  • Cytokines
  • Hyaluronan Receptors
  • Mice
  • Mice, Inbred C57BL
  • Phenotype
  • Programmed Cell Death 1 Receptor
  • Proteasome Endopeptidase Complex
  • Receptors, Antigen, T-Cell
  • Signal Transduction

Keywords

  • T cell receptor signal
  • T cell senescence
  • aging
  • proteasome

CD47

Aging-associated changes in CD47 arrangement and interaction with thrombospondin-1 on red blood cells visualized by super-resolution imaging.


Keywords

  • CD47
  • aging
  • dSTORM
  • red blood cells
  • thrombospondin-1


CD47 Promotes Age-Associated Deterioration in Angiogenesis, Blood Flow and Glucose Homeostasis.


Keywords

  • CD47
  • aging
  • angiogenesis
  • blood flow
  • endothelial cells
  • glucose homeostasis
  • metabolism
  • self-renewal
  • thrombospondin-1


Unique Spatial Immune Profiling in Pancreatic Ductal Adenocarcinoma with Enrichment of Exhausted and Senescent T Cells and Diffused CD47-SIRPα Expression.


Keywords

  • CD47
  • T cell exhaustion
  • T cell senescence
  • draining lymph nodes
  • macrophage checkpoint
  • neoadjuvant chemotherapy
  • pancreatic ductal adenocarcinoma
  • signal regulatory protein alpha (SIRPα)
  • spatial heterogeneity
  • tumor microenvironment

CD5

Comparative proteomic analysis identifies biomarkers for renal aging.


Keywords

  • NMN
  • biomarkers
  • glutathionylation
  • proteomics
  • renal aging

CD63

Cellular senescence contributes to age-dependent changes in circulating extracellular vesicle cargo and function.


Keywords

  • aging
  • extracellular vesicles
  • microRNA
  • plasma
  • senescence
  • senolytic

CD68

Insulin activates microglia and increases COX-2/IL-1β expression in young but not in aged hippocampus.


Keywords

  • Aging
  • Hippocampus
  • Insulin
  • Memory
  • Microglia
  • Neuroinflammation


Epigenetic modulation of macrophage polarization prevents lumbar disc degeneration.


Keywords

  • DNA methyltransferase 1 (DNMT1)
  • aging
  • lumbar disc degeneration (LDD)
  • macrophage polarization
  • transforming growth factor beta 1 (TGFβ1)


Cellular senescence in recurrent tonsillitis and tonsillar hypertrophy in children.


MeSH Terms

  • Antigens, CD
  • Antigens, Differentiation, Myelomonocytic
  • Cellular Senescence
  • Child
  • Germinal Center
  • Humans
  • Hypertrophy
  • Macrophages
  • Palatine Tonsil
  • Recurrence
  • Tonsillectomy
  • Tonsillitis

Keywords

  • Cellular senescence
  • Recurrent tonsillitis
  • Tonsillar hypertrophy


Ginsenoside Rg1 supplementation clears senescence-associated β-galactosidase in exercising human skeletal muscle.


Keywords

  • Cellular senescence
  • Endurance
  • Ergogenic aid
  • Inflammation
  • Macrophage


Histopathological, immunohistochemical, and molecular studies for determination of wound age and vitality in rats.


MeSH Terms

  • Actins
  • Animals
  • Antigens, CD
  • Antigens, Differentiation, Myelomonocytic
  • Cell Movement
  • Fibroblasts
  • Granulation Tissue
  • Immunohistochemistry
  • Macrophages
  • Models, Animal
  • Neovascularization, Physiologic
  • RNA, Messenger
  • Rats, Wistar
  • Re-Epithelialization
  • Skin
  • Time Factors
  • Transforming Growth Factor beta1
  • Vascular Endothelial Growth Factor A
  • Wound Healing
  • Wounds and Injuries

Keywords

  • TGFb1
  • VEGF
  • gene expression
  • immunohistochemistry
  • wound aging

CD80

The aging common marmoset's immune system: From junior to senior.


MeSH Terms

  • Aging
  • Animals
  • CD4-CD8 Ratio
  • Callithrix
  • Female
  • Flow Cytometry
  • Immune System
  • Longevity
  • Male
  • Models, Animal
  • Sex Factors

Keywords

  • aging
  • common marmoset
  • immune system
  • immunosenescence
  • innate and adaptive immunity
  • sex

CD81

Ovarian aging increases small extracellular vesicle CD81 release in human follicular fluid and influences miRNA profiles.


Keywords

  • extracellular vesicles
  • follicular fluid
  • microRNAs
  • reproductive aging


Older Adults with Physical Frailty and Sarcopenia Show Increased Levels of Circulating Small Extracellular Vesicles with a Specific Mitochondrial Signature.


Keywords

  • aging
  • biomarkers
  • exosomes
  • mitochondrial dynamics
  • mitochondrial quality control
  • mitochondrial-derived vesicles (MDVs)
  • mitochondrial-lysosomal axis
  • mitophagy


Increased production of functional small extracellular vesicles in senescent endothelial cells.


Keywords

  • endothelium
  • exosomes
  • extracellular vesicles
  • senescence

CDA

Cumulative Dis/Advantage and Health Pattern in Late Life: A Comparison between Genders and Welfare State Regimes.


MeSH Terms

  • Aged
  • Aged, 80 and over
  • China
  • Cross-Sectional Studies
  • England
  • Female
  • Health Behavior
  • Health Status Disparities
  • Humans
  • Longevity
  • Male
  • Mexico
  • Middle Aged
  • Regression Analysis
  • Self Report
  • Sex Factors
  • Social Class
  • Social Welfare
  • United States

Keywords

  • Cumulative dis/advantage
  • cross-national study
  • health retirement study
  • welfare state theory


Does numerical similarity alter age-related distractibility in working memory?


MeSH Terms

  • Adult
  • Aged
  • Aging
  • Alpha Rhythm
  • Attention
  • Evoked Potentials
  • Female
  • Healthy Volunteers
  • Humans
  • Male
  • Memory, Short-Term
  • Young Adult

CDC20

Premature aging syndrome showing random chromosome number instabilities with CDC20 mutation.


Keywords

  • Cdc20 proteins
  • M phase cell cycle checkpoints
  • aging
  • chromosomal instability
  • chromosome segregation
  • genomic instability
  • premature

CDC25A

Babam2 Regulates Cell Cycle Progression and Pluripotency in Mouse Embryonic Stem Cells as Revealed by Induced DNA Damage.


Keywords

  • Babam2
  • DNA damage
  • cell cycle
  • embryonic stem cells
  • pluripotency
  • senescence

CDC42

Effects of age-dependent changes in cell size on endothelial cell proliferation and senescence through YAP1.


MeSH Terms

  • Adaptor Proteins, Signal Transducing
  • Adult
  • Aging
  • Animals
  • Cell Cycle Proteins
  • Cell Size
  • Endothelial Cells
  • Female
  • Humans
  • Male
  • Mice, Inbred C57BL
  • Middle Aged
  • Neovascularization, Physiologic
  • Primary Cell Culture
  • Transcription Factors
  • cdc42 GTP-Binding Protein

Keywords

  • aging
  • angiogenesis
  • cell proliferation
  • cell size
  • senescence

CDH1

Cdc6 as a novel target in cancer: Oncogenic potential, senescence and subcellular localisation.


Keywords

  • Cdc6
  • cytoplasmic Cdc6
  • pancreatic cancer
  • senescence
  • subcellular localisation

CDK1

MicroRNAomic Transcriptomic Analysis Reveal Deregulation of Clustered Cellular Functions in Human Mesenchymal Stem Cells During in Vitro Passaging.


MeSH Terms

  • CDC2-CDC28 Kinases
  • Cell Differentiation
  • Cell Proliferation
  • Cellular Senescence
  • Cyclin B
  • Gene Expression Regulation, Developmental
  • Humans
  • Mesenchymal Stem Cells
  • MicroRNAs
  • Transcriptome
  • Tumor Suppressor Protein p53
  • Umbilical Cord

Keywords

  • Cell proliferation
  • Cell senescence
  • Cellular ageing
  • Human Mesenchymal stem / stromal cells
  • miRNA-mRNA integration

CDK2

p57 is a master regulator of human adipose derived stem cell quiescence and senescence.


Keywords

  • Human adipose derived stem cells
  • Quiescence
  • Senescence
  • p57(Kip2)

CDK4

Emerging Roles for the [i]INK4a/ARF[/i] ([i]CDKN2A[/i]) Locus in Adipose Tissue: Implications for Obesity and Type 2 Diabetes.


Keywords

  • adipogenesis
  • inflammation
  • insulin sensitivity
  • obesity
  • oxidative activity
  • senescence
  • type 2 diabetes


Guilu Erxian Glue () Inhibits Chemotherapy-Induced Bone Marrow Hematopoietic Stem Cell Senescence in Mice May via p16 -Rb Signaling Pathway.


Keywords

  • Chinese medicine
  • Guilu Erxian Glue
  • bone marrow suppression
  • hematopoietic stem cell senescence
  • p16INK4a

CDK5

Age-related hyperinsulinemia leads to insulin resistance in neurons and cell-cycle-induced senescence.


MeSH Terms

  • Aging
  • Animals
  • Cell Cycle
  • Cell Death
  • Cellular Senescence
  • Cyclin-Dependent Kinase 5
  • Excitatory Postsynaptic Potentials
  • Gene Expression
  • Glycolysis
  • Hexokinase
  • Hyperinsulinism
  • Inhibitory Postsynaptic Potentials
  • Insulin
  • Insulin Resistance
  • Liraglutide
  • Male
  • Maze Learning
  • Metformin
  • Mice
  • Neurons
  • Phosphotransferases
  • Primary Cell Culture
  • Protein-Serine-Threonine Kinases
  • Ubiquitination
  • beta Catenin

CDK6

Saturated Fatty Acids Promote Hepatocytic Senecence through Regulation of miR-34a/Cyclin-Dependent Kinase 6.


Keywords

  • cyclin-dependent kinase 6 (CDK6)
  • high-fat diet (HFD)
  • miR-34a
  • palmitate acid (PA)
  • senescence


Hepatoprotective effects of hydroxysafflor yellow A in D-galactose-treated aging mice.


Keywords

  • D-galactose
  • Hydroxysafflor yellow A
  • Oxidative stress
  • Replicative senescence
  • p16


Anti-cell growth and anti-cancer stem cell activity of the CDK4/6 inhibitor palbociclib in breast cancer cells.


Keywords

  • Breast cancer
  • CDK4
  • Cancer stem cells
  • Palbociclib
  • Senescence


Compromising the constitutive p16 expression sensitizes human neuroblastoma cells to Hsp90 inhibition and promotes premature senescence.


Keywords

  • 17AAG
  • Hsp90
  • cancer
  • p16INK4a
  • senescence
  • tumor suppressor

CDKN1A

Involvement of CDKN1A (p21) in cellular senescence in response to heat and irradiation stress during preimplantation development.


Keywords

  • Cdkn1a
  • Heat stress
  • Irradiation
  • Preimplantation
  • Senescence
  • p21

CDKN2A

Association between Nrf2 and CDKN2A expression in patients with end-stage renal disease: a pilot study.


Keywords

  • CDKN2A
  • Nrf2
  • aging
  • end-stage renal disease
  • inflammation

CDKN2B

Molecular Genetics and Functional Analysis Implicate [i]CDKN2BAS1-CDKN2B[/i] Involvement in POAG Pathogenesis.


Keywords

  • African Americans
  • CDKN2B-AS1
  • Primary open-angle glaucoma (POAG)
  • senescence
  • trabecular meshwork cells

CFI

Psychosocial Resources for Hedonic Balance, Life Satisfaction and Happiness in the Elderly: A Path Analysis.


MeSH Terms

  • Adult
  • Aged
  • Aged, 80 and over
  • Aging
  • Cross-Sectional Studies
  • Female
  • Happiness
  • Health Status
  • Humans
  • Male
  • Personal Satisfaction
  • Quality of Life

Keywords

  • happiness
  • older adults
  • path analysis
  • psychosocial resources
  • subjective well-being


Validity and Reliability of the Flourishing Scale in a Sample of Older Adults in Iran.


MeSH Terms

  • Aged
  • Aging
  • Cross-Sectional Studies
  • Female
  • Geriatric Assessment
  • Health Status Disparities
  • Humans
  • Iran
  • Male
  • Mental Health
  • Psychometrics
  • Reproducibility of Results
  • Surveys and Questionnaires

Keywords

  • aging
  • factor analysis
  • flourishing
  • reliability
  • validity


The decision about retirement: A scale to describe representations and practices of medical doctors and nurses.


Keywords

  • Aging
  • Job satisfaction
  • Retirement
  • Scale


Family versus intimate partners: Estimating who matters more for health in a 20-year longitudinal study.


MeSH Terms

  • Adult
  • Aged
  • Aging
  • Emotions
  • Family Relations
  • Female
  • Health Status
  • Humans
  • Interpersonal Relations
  • Longitudinal Studies
  • Male
  • Middle Aged
  • Sexual Partners
  • United States


Adapting and validating the Rosenberg Self-Esteem Scale for elderly Spanish population.


Keywords

  • aging
  • life span
  • self-esteem
  • structural equation model
  • validity

CFTR

Exercise Physiology Across the Lifespan in Cystic Fibrosis.


Keywords

  • aging
  • cystic fibrosis
  • exercise capacity
  • exercise prescription
  • pediatric


Reduced expression of the Ion channel CFTR contributes to airspace enlargement as a consequence of aging and in response to cigarette smoke in mice.


MeSH Terms

  • Aging
  • Animals
  • Cystic Fibrosis Transmembrane Conductance Regulator
  • Gene Expression
  • Inhalation Exposure
  • Mice
  • Mice, Knockout
  • Pulmonary Emphysema
  • Tobacco Smoke Pollution

Keywords

  • Aging
  • CFTR
  • Emphysema
  • Smoking

CGA

Safety and efficacy of preoperative chemoradiotherapy in fit older patients with intermediate or locally advanced rectal cancer evaluated by comprehensive geriatric assessment: A planned interim analysis of a multicenter, phase II trial.


Keywords

  • Comprehensive geriatric assessment
  • Geriatrics
  • Preoperative chemoradiotherapy
  • Rectal cancer


The Protective Effect of Chlorogenic Acid on Vascular Senescence via the Nrf2/HO-1 Pathway.


Keywords

  • chlorogenic acid
  • heme oxygenase-1
  • nuclear factor erythroid 2-related factor 2
  • vascular senescence


Association between comprehensive geriatric assessment and short-term outcomes among older adult patients with stroke: A nationwide retrospective cohort study using propensity score and instrumental variable methods.


Keywords

  • Comprehensive geriatric assessment
  • Geriatrics
  • Japanese diagnosis procedure combination database
  • Length of stay
  • Mortality
  • Stroke


Interventions to Improve Clinical Outcomes in Older Adults Admitted to a Surgical Service: A Systematic Review and Meta-analysis.


Keywords

  • Aging
  • comprehensive geriatric assessment
  • delirium
  • functional status
  • outcomes
  • surgery


A Computerized Frailty Assessment Tool at Points-of-Care: Development of a Standalone Electronic Comprehensive Geriatric Assessment/Frailty Index (eFI-CGA).


Keywords

  • aging
  • comprehensive geriatric assessment (CGA)
  • electronic assessment tools
  • frailty
  • frailty index
  • healthcare
  • older adults


Allocating patients to geriatric medicine wards in a tertiary university hospital in England: A service evaluation of the Specialist Advice for the Frail Elderly (SAFE) team.


Keywords

  • clinical frailty scale
  • frail older adults
  • geriatrics
  • hospital medicine


Role of Frailty on Risk Stratification in Cardiac Surgery and Procedures.


MeSH Terms

  • Aged
  • Aged, 80 and over
  • Cardiac Surgical Procedures
  • Frail Elderly
  • Frailty
  • Geriatric Assessment
  • Humans
  • Percutaneous Coronary Intervention
  • Risk Assessment
  • Transcatheter Aortic Valve Replacement

Keywords

  • Cardiac surgery
  • Comprehensive geriatric assessment
  • Disability
  • Elderly
  • Frailty
  • Geriatrics
  • Surgical risk scores
  • TAVI


Developing an objective structured clinical examination in comprehensive geriatric assessment - A pilot study.


MeSH Terms

  • Aged
  • Clinical Competence
  • Education, Medical, Graduate
  • Educational Measurement
  • Female
  • Geriatric Assessment
  • Geriatrics
  • Humans
  • Male
  • Pilot Projects
  • United Kingdom

Keywords

  • Comprehensive geriatric assessment
  • development
  • entrustable professional capabilities
  • objective structured clinical examination
  • summative assessment


How do doctors choose treatment for older gynecological cancer patients? A Japanese Gynecologic Oncology Group survey of gynecologic oncologists.


MeSH Terms

  • Aged
  • Aged, 80 and over
  • Comorbidity
  • Female
  • Genital Neoplasms, Female
  • Geriatric Assessment
  • Gynecology
  • Humans
  • Hysterectomy
  • Japan
  • Lymph Node Excision
  • Oncologists
  • Surveys and Questionnaires

Keywords

  • Comprehensive geriatric assessment
  • Elderly
  • Geriatrics
  • Gynecologic cancer


Validation of the Pictorial Fit-Frail Scale in a memory clinic setting.


Keywords

  • aging
  • dementia
  • frail elderly
  • frailty
  • psychometrics


Impact of Resolution of Hyponatremia on Neurocognitive and Motor Performance in Geriatric Patients.


MeSH Terms

  • Activities of Daily Living
  • Aged
  • Aged, 80 and over
  • Aging
  • Cognition
  • Female
  • Geriatrics
  • Humans
  • Hyponatremia
  • Male
  • Mental Status and Dementia Tests
  • Middle Aged
  • Motor Activity
  • Sodium


Health outcome of older hospitalized patients in internal medicine environments evaluated by Identification of Seniors at Risk (ISAR) screening and geriatric assessment.


MeSH Terms

  • Accidental Falls
  • Aged
  • Aged, 80 and over
  • Cohort Studies
  • Emergency Service, Hospital
  • Female
  • Geriatric Assessment
  • Health Status
  • Hospitalization
  • Humans
  • Internal Medicine
  • Length of Stay
  • Male
  • Mass Screening
  • Patient Discharge
  • Risk Assessment

Keywords

  • CGA
  • Cutoff
  • Geriatrics
  • ISAR
  • Internal medicine
  • Older in-patients
  • Risk screening
  • Sensitivity
  • Specificity

CHI3L1

Postsynaptic damage and microglial activation in AD patients could be linked CXCR4/CXCL12 expression levels.


Keywords

  • Aging
  • Alzheimer’s disease
  • Bioinformatics
  • CHI3L1
  • Chitinase
  • NRGN

CHRNA7

Associations between genetic variations and global motion perception.


MeSH Terms

  • Adult
  • Differential Threshold
  • Female
  • Genotype
  • Humans
  • Male
  • Motion Perception
  • Polymorphism, Single Nucleotide
  • Receptors, Nicotinic
  • Sensory Thresholds
  • Young Adult
  • alpha7 Nicotinic Acetylcholine Receptor

Keywords

  • Aging
  • CHRNA7
  • Cholinergic system
  • Coherent motion
  • Genetic variations

CHSY1

Loss of Chondroitin Sulfate Modification Causes Inflammation and Neurodegeneration in [i]skt[/i] Mice.


MeSH Terms

  • Age Factors
  • Animals
  • Apoptosis
  • Chondroitin Sulfates
  • Female
  • Glucuronosyltransferase
  • Inflammation
  • Male
  • Mice
  • Mice, Inbred C57BL
  • Mice, Knockout
  • Multifunctional Enzymes
  • Mutation
  • N-Acetylgalactosaminyltransferases
  • Neurodegenerative Diseases
  • Neurons
  • Protein Processing, Post-Translational
  • Proteins
  • Retinal Degeneration

Keywords

  • aging
  • chondroitin sulfate synthase
  • hippocampus
  • inflammation
  • mouse
  • myeloid cells
  • neurodegeneration
  • retina
  • retinal pigment epithelium
  • subretinal space

CISD2

CISD2 Attenuates Inflammation and Regulates Microglia Polarization in EOC Microglial Cells-As a Potential Therapeutic Target for Neurodegenerative Dementia.


Keywords

  • CISD2
  • M1/M2 microglia polarization
  • aging
  • anti-inflammatory effects
  • neurodegenerative disease and dementia

CIT

Effect of sex on aging-related decline of dopamine transporter in healthy subjects.


Keywords

  • 123I-FP-CIT
  • Aging
  • Dopamine plasma membrane transport proteins
  • SPECT
  • Sex


The Relationship Between the Striatal Dopaminergic Neuronal and Cognitive Function With Aging.


Keywords

  • SPECT
  • Wechsler Adult Intelligence Scale
  • aging
  • cognitive function
  • dopamine transporter
  • verbal function

CLEC3B

CLEC3B p.S106G Mutant in a Caucasian Population of Successful Neurological Aging.


Keywords

         APOE
       
         CLEC3B
       
  • Aging
  • Human genetics
  • Human health

COL1A1

Remodeling process in bone of aged rats in response to resistance training.


MeSH Terms

  • Age Factors
  • Aging
  • Animals
  • Bone Remodeling
  • Gene Expression Regulation
  • Male
  • Physical Conditioning, Animal
  • RNA, Messenger
  • Random Allocation
  • Rats
  • Rats, Wistar
  • Resistance Training

Keywords

  • Aging
  • Bone homeostasis
  • Function
  • Resistance training

COL3A1

Different expression of Defensin-B gene in the endometrium of mares of different age during the breeding season.


MeSH Terms

  • Aging
  • Animals
  • Breeding
  • Defensins
  • Endometrium
  • Female
  • Fibrosis
  • Gene Expression
  • Horses
  • Inflammation
  • Reverse Transcriptase Polymerase Chain Reaction

Keywords

  • Defensin-β
  • Endometrium
  • Gene expression
  • Immune-modulation
  • Mare

COMT

The geriatric pain experience in mice: intact cutaneous thresholds but altered responses to tonic and chronic pain.


MeSH Terms

  • Acetone
  • Aging
  • Animals
  • Behavior
  • Biogenic Monoamines
  • Capsaicin
  • Chronic Pain
  • Disease Models, Animal
  • Male
  • Mice, Inbred C57BL
  • Peripheral Nerve Injuries
  • Physical Stimulation
  • Prefrontal Cortex
  • Sensory Thresholds

Keywords

  • Geriatric pain
  • Healthy aging
  • Mice
  • Sensory thresholds
  • Supraspinal plasticity
  • Tonic and chronic pain response

COPE

Patterns and characteristics of cognitive functioning in older patients approaching end stage kidney disease, the COPE-study.


Keywords

  • Cognitive function
  • End stage renal disease
  • Geriatric assessment
  • Geriatrics
  • Older patients

CORT

Sex differences in body composition, metabolism-related hormones, and energy homeostasis during aging in Wistar rats.


Keywords

  • aging
  • body composition
  • energy metabolism
  • metabolism-related hormone
  • sex differences


Effects of age and social isolation on murine hippocampal biochemistry and behavior.


Keywords

  • Aging
  • Hippocampus
  • Inflammation
  • Memory
  • Serotonin
  • Social isolation
  • Stress


Interleukin 6 reduces allopregnanolone synthesis in the brain and contributes to age-related cognitive decline in mice.


Keywords

  • Alzheimer’s disease
  • aging
  • cognitive function
  • enzyme regulation
  • inflammation
  • neurosteroid
  • progesterone
  • steroid hormones


Sex- and age-dependent differences in the hormone and drinking responses to water deprivation.


MeSH Terms

  • Age Factors
  • Animals
  • Arginine Vasopressin
  • Behavior, Animal
  • Dehydration
  • Drinking
  • Female
  • Male
  • Rats, Wistar
  • Sex Factors
  • Sodium Chloride
  • Subfornical Organ
  • Water Deprivation

Keywords

  • aging
  • hormonal response
  • sex differences
  • sodium appetite
  • thirst


Ontogeny of the adrenocortical response in an extremely altricial bird.


MeSH Terms

  • Adrenal Glands
  • Aging
  • Animals
  • Corticosterone
  • Female
  • Hypothalamo-Hypophyseal System
  • Male
  • Parrots
  • Restraint, Physical
  • Stress, Physiological

Keywords

  • Venezuela
  • adrenocortical
  • altricial
  • birds
  • corticosterone
  • glucocorticoid
  • hypothalamic-pituitary-adrenal axis
  • ontogeny
  • parrots
  • stress

CP

A Life Course Perspective on Growing Older With Cerebral Palsy.


Keywords

  • aging
  • cerebral palsy
  • midlife
  • neurological disorders
  • neurology
  • qualitative descriptive


The molecular anatomy and functions of the choroid plexus in healthy and diseased brain.


Keywords

  • Aging
  • Alzheimer's disease
  • Choroid plexus
  • Development
  • Multiple sclerosis
  • Neuroprotection


The effects and mechanism of collagen peptide and elastin peptide on skin aging induced by D-galactose combined with ultraviolet radiation.


Keywords

  • Collagen
  • D-galactose
  • Elastin
  • Skin aging
  • Ultraviolet


Model based strategies towards protein A resin lifetime optimization and supervision.


MeSH Terms

  • Algorithms
  • Chromatography
  • Kinetics
  • Least-Squares Analysis
  • Ligands
  • Models, Theoretical
  • Principal Component Analysis
  • Resins, Plant
  • Staphylococcal Protein A
  • Statistics as Topic

Keywords

  • Cleaning procedures
  • Hybrid modeling
  • Multivariate data analysis
  • Protein A chromatography
  • Resin aging
  • Resin lifetime


The influence of age and environmental conditions on supplement intake by beef cattle winter grazing northern mixed-grass rangelands.


MeSH Terms

  • Aging
  • Animal Feed
  • Animal Husbandry
  • Animals
  • Cattle
  • Diet
  • Dietary Supplements
  • Ecosystem
  • Female
  • Poaceae
  • Seasons
  • Weather

Keywords

  • beef cattle
  • cow age
  • environment
  • supplement intake
  • winter grazing


Cyclophosphamide, a cancer chemotherapy drug-induced early onset of reproductive senescence and alterations in reproductive performance and their prevention in mice.


Keywords

  • Cyclophosphamide
  • Decalepis hamiltonii
  • premature ovarian failure
  • reproductive performance
  • reproductive senescence
  • uterus


Asymptomatic [i]Clostridium perfringens[/i] Inhabitation in Intestine Can Cause Inflammation, Apoptosis, and Disorders in Brain.


MeSH Terms

  • Aging
  • Animals
  • Apoptosis
  • Asymptomatic Infections
  • Brain
  • Brain Diseases
  • Clostridium Infections
  • Clostridium perfringens
  • Disease Models, Animal
  • Feces
  • Food Microbiology
  • Gene Expression
  • Humans
  • Inflammation
  • Intestines
  • Liver
  • Male
  • Mice
  • Mice, Inbred C57BL
  • Organ Size
  • Oxidative Stress
  • Risk Factors
  • Spleen

Keywords

  • Clostridium perfringens
  • brain damage
  • brain disorder
  • gut microbiota


The Role of the Clinical Pharmacist in the Management of People Living with HIV in the Modern Antiretroviral Era.


MeSH Terms

  • Aged
  • Aged, 80 and over
  • Anti-Retroviral Agents
  • Disease Management
  • Disease Transmission, Infectious
  • Female
  • HIV Infections
  • Humans
  • Male
  • Medication Adherence
  • Middle Aged
  • Pharmacists
  • Professional Role
  • Treatment Outcome

Keywords

  • Aging
  • Antiretroviral therapy
  • Clinical pharmacist
  • Comorbidities
  • HIV


A clinically feasible method for the assessment and characterization of pain in patients with chronic pancreatitis.


MeSH Terms

  • Adult
  • Aging
  • Case-Control Studies
  • Cross-Sectional Studies
  • Humans
  • Middle Aged
  • Pain
  • Pain Measurement
  • Pancreatitis, Chronic
  • Sex Factors

Keywords

  • Central sensitization
  • Chronic pancreatitis
  • Nociception
  • Pain


Differences in geometric strength at the contralateral hip between men with hip fracture and non-fractured comparators.


Keywords

  • Aging
  • DXA
  • Fracture prevention
  • Injury/fracture healing
  • Osteoporosis


Factors associated with the number of clinical pharmacy recommendations: findings from an observational study in geriatric inpatients.


Keywords

  • Clinical pharmacy
  • geriatrics
  • inpatients
  • polypharmacy
  • risk stratification


Protection against oxidative stress and anti-aging effect in Drosophila of royal jelly-collagen peptide.


MeSH Terms

  • Aging
  • Amino Acids
  • Animals
  • Body Weight
  • Collagen
  • Drosophila
  • Fatty Acids
  • Feeding Behavior
  • Hydrogen Peroxide
  • Longevity
  • Molecular Weight
  • Oxidative Stress
  • Paraquat

Keywords

  • Anti-aging
  • Antioxidant activity
  • Collagen
  • Drosophila
  • Royal jelly

CPM

Test-Retest Instability of Temporal Summation and Conditioned Pain Modulation Measures in Older Adults.


Keywords

  • Aging
  • Anxiety
  • Conditioned Pain Modulation
  • Pain Catastrophizing
  • Reliability
  • Temporal Summation of Pain


Age does not affect sex effect of conditioned pain modulation of pressure and thermal pain across 2 conditioning stimuli.


Keywords

  • Aging
  • CPM duration
  • Conditioned pain modulation
  • Conditioning stimulus
  • Sex differences
  • Test stimulus


The Decline of Endogenous Pain Modulation With Aging: A Meta-Analysis of Temporal Summation and Conditioned Pain Modulation.


Keywords

  • Aging
  • conditioned pain modulation
  • meta-analysis
  • pain modulation
  • temporal summation

CPNE1

Prevalent intron retention fine-tunes gene expression and contributes to cellular senescence.


Keywords

  • CPNE1
  • U2AF1
  • intron retention
  • senescence
  • splicing factor

CPT1A

Alteration of fatty acid oxidation by increased CPT1A on replicative senescence of placenta-derived mesenchymal stem cells.


Keywords

  • CPT1A
  • Fatty acid
  • Mitochondria
  • Placenta-derived mesenchymal stem cell
  • Senescence

CPT1C

Carnitine palmitoyltransferase 1C reverses cellular senescence of MRC-5 fibroblasts via regulating lipid accumulation and mitochondrial function.


Keywords

  • MRC-5 fibroblasts
  • carnitine palmitoyltransferase 1C (CPT1C)
  • cellular senescence
  • lipidomics
  • mitochondrial function


Carnitine palmitoyltransferase 1C contributes to progressive cellular senescence.


Keywords

  • carnitine palmitoyltransferase 1C
  • metabolic reprogramming
  • mitochondria
  • senescence
  • stable transfection

CPT2

The phytochemical epigallocatechin gallate prolongs the lifespan by improving lipid metabolism, reducing inflammation and oxidative stress in high-fat diet-fed obese rats.


Keywords

  • EGCG
  • free fatty acid
  • high-fat dietary
  • lifespan
  • proteomics
  • transcriptome

CR1

Single Nucleotide Polymorphisms in Alzheimer's Disease Risk Genes Are Associated with Intrinsic Connectivity in Middle Age.


Keywords

  • Aging
  • Alzheimer’s disease
  • middle aged
  • neuroimaging
  • single nucleotide

polymorphism


The whale shark genome reveals how genomic and physiological properties scale with body size.


MeSH Terms

  • Adaptation, Physiological
  • Animals
  • Base Sequence
  • Body Size
  • Genome
  • Genomics
  • Longevity
  • Sharks
  • Temperature

Keywords

  • body size
  • lifespan
  • metabolic rate
  • neural genes
  • whale shark

CRABP2

Preconception resveratrol intake against infertility: Friend or foe?


Keywords

  • aging
  • assisted reproductive technology
  • infertility
  • resveratrol
  • sirtuin

CRBN

Using proteolysis-targeting chimera technology to reduce navitoclax platelet toxicity and improve its senolytic activity.


MeSH Terms

  • Adaptor Proteins, Signal Transducing
  • Aging
  • Aniline Compounds
  • Animals
  • Blood Platelets
  • Cell Line
  • Cellular Senescence
  • Female
  • Humans
  • Male
  • Mice
  • Mice, Transgenic
  • Models, Animal
  • Primary Cell Culture
  • Proteolysis
  • Sulfonamides
  • Ubiquitin-Protein Ligases
  • bcl-X Protein

CRP

Omega-3 supplementation improves isometric strength but not muscle anabolic and catabolic signaling in response to resistance exercise in healthy older adults.


Keywords

  • Muscle wasting
  • aging
  • anabolic resistance
  • inflammation
  • resistance training
  • sarcopenia


Circulating angiopoietin-like protein 2 levels and arterial stiffness in patients receiving maintenance hemodialysis: A cross-sectional study.


Keywords

  • Angiopoietin-like protein (ANGPTL) 2
  • Cardio-ankle vascular index (CAVI)
  • Chronic inflammation
  • Hemodialysis
  • Senescence


Cardiovascular rehabilitation in patients aged 70-year-old or older: benefits on functional capacity, physical activity and metabolic profile in younger [i]vs[/i]. older patients.


Keywords

  • Aging
  • Cardiovascular prevention
  • Exercise-based cardiac rehabilitation


rRT-PCR Results of a Covid-19 Diagnosed Geriatric Patient.


Keywords

  • COVID-19
  • False negative reactions
  • Geriatrics
  • Mass screening
  • Reverse transcriptase polymerase chain reaction
  • SARS-CoV-2
  • Tomography


The Association of Aging Biomarkers, Interstitial Lung Abnormalities, and Mortality.


Keywords

  • aging
  • growth differentiation factor 15
  • idiopathic pulmonary fibrosis
  • interstitial lung abnormalities
  • mortality


A Novel Fortified Dairy Product and Sarcopenia Measures in Sarcopenic Older Adults: A Double-Blind Randomized Controlled Trial.


Keywords

  • Functional food
  • aging
  • beta-hydroxy beta-methylbutyrate
  • muscle strength
  • sarcopenia
  • vitamin D


Age-Related Colonic Mucosal Microbiome Community Shifts in Monkeys.


Keywords

  • Aging
  • Microbial co-occurrences
  • Mucosal microbiome
  • Systemic inflammation


The relationship between frailty and serum alpha klotho levels in geriatric patients.


Keywords

  • Aging
  • Biomarkers
  • Frailty syndrome
  • Geriatric syndrome
  • Sarcopenia


ZMPSTE24 Is Associated with Elevated Inflammation and Progerin mRNA.


Keywords

  • ZMPSTE24
  • aging
  • inflammation
  • lamin A/C
  • progerin


Cultural and life style practices associated with low inflammatory physiology in Japanese adults.


Keywords

  • Aging
  • Bathing
  • C-reactive protein
  • Diet
  • Inflammation
  • Interleukin-6
  • Japan
  • Tea


Moderate- to high intensity aerobic and resistance exercise reduces peripheral blood regulatory cell populations in older adults with rheumatoid arthritis.


Keywords

  • Aging
  • Breg cells
  • Exercise
  • IL-10
  • Rheumatoid arthritis
  • T cells
  • Treg cells


PTSD and the klotho longevity gene: Evaluation of longitudinal effects on inflammation via DNA methylation.


Keywords

  • Accelerated aging
  • Inflammation
  • Klotho
  • Methylation
  • PTSD


Bereavement is associated with reduced systemic inflammation: C-reactive protein before and after widowhood.


Keywords

  • Aging
  • Bereavement
  • C-reactive protein
  • Health
  • Inflammation
  • Widowhood


The Impact of Age on the Prevalence of Sarcopenic Obesity in Bariatric Surgery Candidates.


Keywords

  • Aging
  • Bariatric surgery
  • Elderly
  • Obesity
  • Sarcopenia


Intake of dietary advanced glycation end products influences inflammatory markers, immune phenotypes, and antiradical capacity of healthy elderly in a little-studied population.


Keywords

  • CRP
  • advanced glycationed end products
  • aging
  • dAGE
  • immunity
  • inflammation


Intentional Switching Between Bimanual Coordination Patterns in Older Adults: Is It Mediated by Inhibition Processes?


Keywords

  • Stroop task
  • aging
  • bimanual coordination
  • inhibition
  • mediation analysis
  • switching


Shorter Telomere Length in Peripheral Blood Leukocytes Is Associated with Post-Traumatic Chronic Osteomyelitis.


Keywords

  • aging
  • post-traumatic chronic osteomyelitis
  • telomere


Risk Factors of Progression to Frailty: Findings from the Singapore Longitudinal Ageing Study.


MeSH Terms

  • Aged
  • Aged, 80 and over
  • Aging
  • Disease Progression
  • Female
  • Frail Elderly
  • Frailty
  • Geriatric Assessment
  • Humans
  • Independent Living
  • Longitudinal Studies
  • Male
  • Nutrition Assessment
  • Nutritional Status
  • Physical Examination
  • Risk Factors
  • Singapore
  • Socioeconomic Factors

Keywords

  • Frailty
  • longitudinal
  • risk factors
  • transition


Physical Function and Strength in Relation to Inflammation in Older Adults with Obesity and Increased Cardiometabolic Risk.


MeSH Terms

  • Aged
  • Aging
  • Cardiovascular Diseases
  • Female
  • Humans
  • Inflammation
  • Male
  • Muscle Strength
  • Obesity
  • Physical Exertion

Keywords

  • Inflammation
  • cardiovascular disease risk factors
  • obesity
  • physical activity
  • physical function


Key diagnostic characteristics of fever of unknown origin in Japanese patients: a prospective multicentre study.


MeSH Terms

  • Adult
  • Aged
  • Aged, 80 and over
  • Female
  • Fever of Unknown Origin
  • Humans
  • Japan
  • Male
  • Middle Aged
  • Prospective Studies
  • Young Adult

Keywords

  • Japan
  • aging population
  • elderly
  • erythrocyte sedimentation rate
  • fever of unknown origin
  • prospective studies


Decrease in Serum Vitamin D Level of Older Patients with Fatigue.


MeSH Terms

  • Aged
  • Cohort Studies
  • Fatigue
  • Female
  • Humans
  • Male
  • Middle Aged
  • Vitamin D
  • Vitamin D Deficiency

Keywords

  • aging
  • mental fatigue
  • older
  • physical fatigue
  • sex differences
  • vitamin D


The Association between Frailty Indicators and Blood-Based Biomarkers in Early-Old Community Dwellers of Thailand.


MeSH Terms

  • Aged
  • Aged, 80 and over
  • Biomarkers
  • C-Reactive Protein
  • CD4-CD8 Ratio
  • Cross-Sectional Studies
  • Female
  • Frail Elderly
  • Frailty
  • Humans
  • Independent Living
  • Interleukin-6
  • Male
  • Middle Aged
  • Thailand

Keywords

  • C-reactive protein
  • Thailand
  • aging
  • cross-sectional study
  • frailty
  • frailty biomarkers
  • fried’s phenotypes
  • interleukin-6


Associations of C-reactive protein and homocysteine concentrations with the impairment of intrinsic capacity domains over a 5-year follow-up among community-dwelling older adults at risk of cognitive decline (MAPT Study).


MeSH Terms

  • Activities of Daily Living
  • Aged
  • Biomarkers
  • Body Mass Index
  • C-Reactive Protein
  • Cognitive Dysfunction
  • Depression
  • Female
  • Follow-Up Studies
  • Geriatric Assessment
  • Hand Strength
  • Homocysteine
  • Humans
  • Independent Living
  • Inflammation
  • Male
  • Mobility Limitation
  • Neuropsychological Tests
  • Prospective Studies
  • Risk Factors
  • Time Factors

Keywords

  • Aging
  • C-reactive protein
  • Homocysteine
  • Inflammation
  • Intrinsic capacity
  • Older adults


Longitudinal analysis of loneliness and inflammation at older ages: English longitudinal study of ageing.


MeSH Terms

  • Age Factors
  • Aged
  • Aged, 80 and over
  • Aging
  • C-Reactive Protein
  • England
  • Female
  • Ferritins
  • Fibrinogen
  • Humans
  • Inflammation
  • Loneliness
  • Longitudinal Studies
  • Male
  • Middle Aged

Keywords

  • C-reactive protein
  • Ferritin
  • Fibrinogen
  • Inflammation
  • Loneliness


The cortisol burden in elderly subjects with metabolic syndrome and its association with low-grade inflammation.


MeSH Terms

  • Aged
  • Aged, 80 and over
  • Echocardiography
  • Female
  • Humans
  • Hydrocortisone
  • Inflammation
  • Male
  • Metabolic Syndrome

Keywords

  • Aging
  • Cortisol
  • Inflammation
  • Metabolic syndrome


Recurrent circadian fasting (RCF) improves blood pressure, biomarkers of cardiometabolic risk and regulates inflammation in men.


MeSH Terms

  • Adult
  • Biomarkers
  • Blood Pressure
  • C-Reactive Protein
  • Cardiovascular Diseases
  • Circadian Rhythm
  • Diet
  • Energy Intake
  • Fasting
  • Heart Rate
  • Humans
  • Inflammation
  • Male
  • Metabolic Diseases
  • Middle Aged
  • Nutritional Physiological Phenomena
  • Regression Analysis
  • Risk Factors
  • Young Adult

Keywords

  • Aging
  • Health benefits
  • Inflammation
  • Recurrent fasting


Characteristics of patients with rheumatoid arthritis undergoing primary total joint replacement: A 14-year trend analysis (2004-2017).


MeSH Terms

  • Adult
  • Aged
  • Antirheumatic Agents
  • Arthritis, Rheumatoid
  • Arthroplasty, Replacement
  • Arthroplasty, Replacement, Knee
  • Biological Products
  • Drug Utilization
  • Female
  • Humans
  • Japan
  • Male
  • Middle Aged
  • Postoperative Complications

Keywords

  • C-reactive protein
  • Rheumatoid arthritis
  • aging
  • arthroplasty
  • drug therapy

CS

Acute effect of bodyweight-based strength training on blood pressure of hypertensive older adults: A randomized crossover clinical trial.


Keywords

  • Exercise
  • aging
  • hypertension
  • hypotension
  • resistance training


Particle growth with photochemical age from new particle formation to haze in the winter of Beijing, China.


Keywords

  • Condensation sink
  • Haze
  • New particle formation
  • Photochemical aging
  • Pollution evolution


Effect of aging on stabilization of Cd and Ni by biochars and enzyme activities in a historically contaminated alkaline agricultural soil simulated with wet-dry and freeze-thaw cycling.


Keywords

  • Accelerated aging
  • Biochar
  • Cadmium
  • Enzyme activity
  • Heavy metal stabilization
  • Soil remediation


Cockayne syndrome proteins CSA and CSB maintain mitochondrial homeostasis through NAD signaling.


Keywords

  • AMPK
  • Cockayne syndrome
  • NAD+
  • accelerated ageing
  • aging
  • mitochondrial maintenance
  • mitophagy


Vision Impairment and Participation in Cognitively Stimulating Activities: The Health ABC Study.


Keywords

  • Cognition
  • Cognitive Aging
  • Sensory
  • Vision loss


Suspension training vs. traditional resistance training: effects on muscle mass, strength and functional performance in older adults.


Keywords

  • Aging
  • Functionality
  • Instability resistance training
  • Muscle hypertrophy
  • TRX training


Generational Differences in the 10-year Incidence of Impaired Contrast Sensitivity.


Keywords

  • Aging
  • Birth Cohort Effect
  • Contrast Sensitivity
  • Epidemiology
  • Visual Function


Inducible aging in Hydra oligactis implicates sexual reproduction, loss of stem cells, and genome maintenance as major pathways.


Keywords

  • Aging
  • Cold-sensitive
  • DNA repair
  • Gametogenesis
  • Hydra oligactis
  • Transcriptome


Noradrenergic Responsiveness Supports Selective Attention across the Adult Lifespan.


MeSH Terms

  • Adult
  • Aged
  • Aging
  • Attention
  • Brain Waves
  • Cortical Synchronization
  • Humans
  • Male
  • Norepinephrine
  • Reflex, Pupillary

Keywords

  • cognitive aging
  • locus coeruleus
  • noradrenaline
  • norepinephrine
  • rhythmic neural activity
  • selective attention


Cellular senescence: from anti-cancer weapon to anti-aging target.


MeSH Terms

  • Aging
  • Animals
  • Antineoplastic Agents
  • Breast Neoplasms
  • Cell Proliferation
  • Cell Transformation, Neoplastic
  • Cellular Senescence
  • Cyclin-Dependent Kinases
  • Drug Discovery
  • Female
  • Humans
  • Piperazines
  • Protein Kinase Inhibitors
  • Pyridines

Keywords

  • cancer
  • cellular senescence
  • healthy aging
  • pro-senescence cancer therapy
  • senolytic therapies


Extra-mitochondrial citrate synthase initiates calcium oscillation and suppresses age-dependent sperm dysfunction.


MeSH Terms

  • Aging
  • Animals
  • Calcium Signaling
  • Citrate (si)-Synthase
  • Citric Acid Cycle
  • Female
  • Infertility, Male
  • Male
  • Metabolome
  • Mice
  • Ovum
  • Spermatozoa


Pathogenesis of chronic obstructive pulmonary disease (COPD) induced by cigarette smoke.


Keywords

  • Airway inflammation
  • autophagy
  • cellular senescence
  • chronic obstructive pulmonary disease (COPD)
  • necroptosis
  • oxidative stress


Possible Role of Amyloid Cross-Seeding in Evolvability and Neurodegenerative Disease.


MeSH Terms

  • Aging
  • Amyloidogenic Proteins
  • Animals
  • Biological Evolution
  • Brain
  • Female
  • Humans
  • Inheritance Patterns
  • Models, Neurological
  • Neurodegenerative Diseases
  • Pregnancy
  • Stress, Physiological

Keywords

  • Alzheimer’s disease
  • Parkinson’s disease
  • amyloid cascade hypothesis
  • amyloidogenic proteins
  • antimicrobial protection model
  • cross-seeding
  • evolvability hypothesis


Targeting p16-induced senescence prevents cigarette smoke-induced emphysema by promoting IGF1/Akt1 signaling in mice.


MeSH Terms

  • Alveolar Epithelial Cells
  • Animals
  • Cell Proliferation
  • Cellular Senescence
  • Cyclin-Dependent Kinase Inhibitor p16
  • Cytokines
  • Emphysema
  • Insulin-Like Growth Factor I
  • Lung
  • Mice, Inbred C57BL
  • Models, Biological
  • Promoter Regions, Genetic
  • Proto-Oncogene Proteins c-akt
  • Pulmonary Disease, Chronic Obstructive
  • RNA, Messenger
  • Signal Transduction
  • Smoking

Keywords

  • Molecular biology
  • Senescence
  • Stem cells

CSF1R

CSF1R inhibitor PLX5622 and environmental enrichment additively improve metabolic outcomes in middle-aged female mice.


Keywords

  • CSF1R
  • adipose
  • aging
  • environmental enrichment
  • microglia


Modulation of Microglia by Voluntary Exercise or CSF1R Inhibition Prevents Age-Related Loss of Functional Motor Units.


MeSH Terms

  • Aging
  • Animals
  • Cell Line
  • Databases, Genetic
  • Humans
  • Induced Pluripotent Stem Cells
  • Macrophages
  • Male
  • Mice
  • Mice, Inbred C57BL
  • Microglia
  • Motor Neurons
  • Muscle, Skeletal
  • Neuromuscular Junction
  • Neuronal Plasticity
  • Physical Conditioning, Animal
  • RNA-Seq
  • Receptors, Granulocyte-Macrophage Colony-Stimulating Factor
  • Spinal Cord

Keywords

  • CSF1R inhibition
  • aging
  • exercise
  • innervation
  • microglia
  • motor unit
  • neuroinflammation
  • neuromuscular junction
  • neuromuscular system
  • spinal cord

CTCF

New targeted approaches for epigenetic age predictions.


Keywords

  • Aging
  • Amplicon sequencing
  • Blood
  • Buccal swabs
  • CTCF
  • DNA methylation
  • Droplet digital PCR
  • Epigenetic
  • Human

CTH

Anterior Cingulate Structure and Perfusion is Associated with Cerebrospinal Fluid Tau among Cognitively Normal Older Adult APOEɛ4 Carriers.


Keywords

  • APOE
  • Aging
  • Alzheimer’s disease
  • cerebral blood flow
  • cognition
  • cognitive decline
  • grey matter
  • magnetic resonance imaging
  • tau proteins

CTLA4

Horticultural Therapy Reduces Biomarkers of Immunosenescence and Inflammaging in Community-Dwelling Older Adults: A Feasibility Pilot Randomized Controlled Trial.


Keywords

  • CTLA-4
  • Geroscience
  • IL-6
  • Immunosenescence
  • Inflammaging

CTRL

Aging reduces the maximal level of peripheral fatigue tolerable and impairs exercise capacity.


Keywords

  • aging
  • critical torque
  • exercise performance
  • group III/IV muscle afferents
  • neuromuscular fatigue


miR-146a Plasma Levels Are Not Altered in Alzheimer's Disease but Correlate With Age and Illness Severity.


Keywords

  • Alzheimer’s disease
  • aging
  • blood
  • miR-146a
  • microRNA
  • plasma


Centrally-mediated regulation of peripheral fatigue during knee extensor exercise and consequences on the force-duration relationship in older men.


Keywords

  • Aging
  • critical torque
  • group III/IV muscle afferents

CTSA

A CTSA-based consultation service to advance research on special and underserved populations.


Keywords

  • faculty development
  • geriatrics
  • grant review
  • grant studio
  • pediatrics
  • peer review
  • research consultation service
  • special populations
  • underrepresented minorities

CTSB

Myocardial cathepsin D is downregulated in sudden cardiac death.


MeSH Terms

  • Adult
  • Aged
  • Aged, 80 and over
  • Aging
  • Cathepsin D
  • Death, Sudden, Cardiac
  • Down-Regulation
  • Female
  • Humans
  • Male
  • Middle Aged
  • Myocardium
  • Substrate Specificity

CX3CL1

Two forms of CX3CL1 display differential activity and rescue cognitive deficits in CX3CL1 knockout mice.


Keywords

  • Aging
  • CX3CL1
  • Cognition
  • Fractalkine
  • Long-term potentiation
  • Microglia
  • Neurodegeneration
  • Neurogenesis
  • Neuroinflammation

CX3CR1

Monocytes present age-related changes in phospholipid concentration and decreased energy metabolism.


Keywords

  • DNA methylation
  • aging
  • glucose metabolism
  • monocytes
  • phosphatidylcholines
  • transcriptome


Muscle Injury Induces Postoperative Cognitive Dysfunction.


MeSH Terms

  • Aging
  • Animals
  • Brain
  • Brain-Derived Neurotrophic Factor
  • CX3C Chemokine Receptor 1
  • Cytokines
  • Disease Models, Animal
  • Hippocampus
  • Humans
  • Male
  • Mice
  • Microglia
  • Muscle, Skeletal
  • Nerve Growth Factor
  • Postoperative Cognitive Complications
  • Postoperative Complications

CXCL1

Contusion spinal cord injury upregulates p53 protein expression in rat soleus muscle at multiple timepoints but not key senescence cytokines.


Keywords

  • SASP
  • cytokines
  • inflammation
  • paralysis
  • senescence
  • spinal cord injury


Systemic Inflammation and the Increased Risk of Inflamm-Aging and Age-Associated Diseases in People Living With HIV on Long Term Suppressive Antiretroviral Therapy.


MeSH Terms

  • Adult
  • Aging
  • Anti-HIV Agents
  • Antiretroviral Therapy, Highly Active
  • Biomarkers
  • CD4 Lymphocyte Count
  • Computational Biology
  • Cross-Sectional Studies
  • Disease Susceptibility
  • Duration of Therapy
  • Female
  • HIV Infections
  • Humans
  • Inflammation
  • Male
  • Metabolome
  • Metabolomics
  • Middle Aged
  • Proteomics
  • Telomere Homeostasis
  • Viral Load

Keywords

  • HIV
  • India
  • LMIC (lower middle income country)
  • inflammation markers
  • long term antiretroviral therapy

CXCL10

Age-related decline of interferon-gamma responses in macrophage impairs satellite cell proliferation and regeneration.


Keywords

  • Aging
  • CXCL10
  • IFN-γ
  • Macrophage
  • Muscle regeneration
  • Single-cell RNA sequence

CXCL11

Endothelial cells under therapy-induced senescence secrete CXCL11, which increases aggressiveness of breast cancer cells.


Keywords

  • CXCL11
  • Endothelial cells
  • Therapy-induced senescence
  • Tumor microenvironment

CXCL12

Co-option of Neutrophil Fates by Tissue Environments.


Keywords

  • angiogenesis
  • immune heterogeneity
  • immune niche
  • innate immunity
  • neutrophil lifespan
  • neutrophils
  • single-cell analysis
  • tissue-resident cells


Heme oxygenase-1 deficiency triggers exhaustion of hematopoietic stem cells.


Keywords

  • aging
  • bone marrow
  • cxcl12-abudant reticular cells
  • endothelial cells
  • niche


Global Transcriptomic Profiling of the Bone Marrow Stromal Microenvironment during Postnatal Development, Aging, and Inflammation.


MeSH Terms

  • Aging
  • Animals
  • Bone Marrow
  • Bone Marrow Cells
  • Cell Differentiation
  • Cells, Cultured
  • Cellular Microenvironment
  • Chemokine CXCL12
  • Embryonic Development
  • Endothelial Cells
  • Gene Expression Profiling
  • Hematopoiesis
  • Hematopoietic Stem Cells
  • Inflammation
  • Male
  • Mesenchymal Stem Cells
  • Mice
  • Mice, Inbred C57BL
  • Stem Cell Niche
  • Transcriptome

Keywords

  • aging
  • bone marrow microenvironment
  • hematopoietic stem cells
  • inflammation
  • niches
  • stromal cells
  • transcriptomics

CXCL13

RNA-seq data from C-X-C chemokine receptor type 5 (CXCR5) gene knockout aged mice with retinal degeneration phenotype.


Keywords

  • CXCR5
  • FastQC
  • RNA-Seq
  • aging
  • choroid
  • mice
  • retina
  • retinal degeneration

CXCL14

Identification of genes associated with endometrial cell aging.


Keywords

  • CXCL12
  • CXCL14
  • IL17RB
  • endometrial cell aging
  • infertility
  • quantitative

immunohistochemistry

CXCL8

Cerebrovascular Senescence Is Associated With Tau Pathology in Alzheimer's Disease.


Keywords

  • Alzheimer's disease
  • endothelial senescence
  • gene expression
  • neurofibrillary tangles
  • plasma biomarkers
  • tau pathology
  • vascular dysfunction

CXCL9

CXCL9 and CXCL10 display an age-dependent profile in Chagas patients: a cohort study of aging in Bambui, Brazil.


MeSH Terms

  • Aged
  • Aged, 80 and over
  • Aging
  • Biomarkers
  • Brazil
  • Chagas Disease
  • Chemokine CXCL10
  • Chemokine CXCL9
  • Cohort Studies
  • Electrocardiography
  • Female
  • Humans
  • Male
  • Middle Aged
  • Trypanosoma cruzi

Keywords

  • Chagas disease
  • Chemokines
  • Cohort
  • Cytokines
  • Immune biomarkers

CXCR2

CXCL5-CXCR2 signaling is a senescence-associated secretory phenotype in preimplantation embryos.


Keywords

  • CXCL5
  • CXCR2
  • SASP
  • aging
  • infertility
  • preimplantation embryo


Senescence in Wound Repair: Emerging Strategies to Target Chronic Healing Wounds.


Keywords

  • ageing
  • diabetes
  • senescence
  • senolytics
  • wound healing

CXCR3

Senescent hepatocytes enhance natural killer cell activity via the CXCL-10/CXCR3 axis.


Keywords

  • chemokine
  • hepatocyte
  • natural killer cell
  • senescence

CXCR4

Aging-Related Reduced Expression of CXCR4 on Bone Marrow Mesenchymal Stromal Cells Contributes to Hematopoietic Stem and Progenitor Cell Defects.


Keywords

  • Aging
  • CXCR4 and ROS
  • HSPC
  • MSC


Transfer of a human gene variant associated with exceptional longevity improves cardiac function in obese type 2 diabetic mice through induction of the SDF-1/CXCR4 signalling pathway.


Keywords

  • BPIFB4
  • Cardiomyopathy
  • Diabetes
  • Gene therapy
  • Longevity


Stromal Cell-Derived Factor 1 Protects Brain Vascular Endothelial Cells from Radiation-Induced Brain Damage.


MeSH Terms

  • Animals
  • Blood Vessels
  • Brain
  • Cell Line
  • Cellular Senescence
  • Chemokine CXCL12
  • Cranial Irradiation
  • Disease Models, Animal
  • Down-Regulation
  • Endothelial Cells
  • Female
  • Gene Expression Regulation
  • Humans
  • Lipopeptides
  • Mice
  • Receptors, CXCR4
  • Signal Transduction

Keywords

  • CXCR4
  • SDF-1
  • brain disorder
  • endothelial dysfunction
  • ionizing radiation
  • senescence

CYP11B1

Intratumoral heterogeneity of the tumor cells based on in situ cortisol excess in cortisol-producing adenomas; ∼An association among morphometry, genotype and cellular senescence∼.


Keywords

  • CYP11B1
  • CYP17A
  • Cellular senescence
  • Compact and clear cells
  • Cortisol-producing adenoma
  • PRKACA

CYP1A1

Genome-wide scan identified genetic variants associated with skin aging in a Chinese female population.


MeSH Terms

  • Adult
  • Aged
  • Aged, 80 and over
  • Asian Continental Ancestry Group
  • Cheek
  • Cohort Studies
  • Cytochrome P-450 CYP1A1
  • European Continental Ancestry Group
  • Female
  • Genome-Wide Association Study
  • Humans
  • Middle Aged
  • Polymorphism, Single Nucleotide
  • Risk Factors
  • Skin Aging
  • Skin Pigmentation

Keywords

  • Candidate SNPs
  • Chinese Han females
  • GWAS
  • Skin aging

CYP26B1

Increased Retinoic Acid Catabolism in Olfactory Sensory Neurons Activates Dormant Tissue-Specific Stem Cells and Accelerates Age-Related Metaplasia.


MeSH Terms

  • Aging
  • Animals
  • Female
  • Isotretinoin
  • Male
  • Metaplasia
  • Mice
  • Neural Stem Cells
  • Neurogenesis
  • Olfactory Mucosa
  • Olfactory Receptor Neurons
  • Retinoic Acid 4-Hydroxylase

Keywords

  • aging
  • inositol-1,4,5-triphosphate
  • metaplasia
  • olfactory epithelium
  • retinoic acid
  • stem cells

CYP2C19

Physiologically Based Pharmacokinetic Approach Can Successfully Predict Pharmacokinetics of Citalopram in Different Patient Populations.


Keywords

  • citalopram
  • genetic polymorphism
  • geriatrics
  • physiologically based pharmacokinetic modeling


Longitudinal exposure of English primary care patients to pharmacogenomic drugs: An analysis to inform design of pre-emptive pharmacogenomic testing.


MeSH Terms

  • Aged
  • Aged, 80 and over
  • Aging
  • Cytochrome P-450 CYP2C19
  • Cytochrome P-450 CYP2D6
  • Drug Prescriptions
  • Female
  • Humans
  • Liver-Specific Organic Anion Transporter 1
  • Longitudinal Studies
  • Male
  • Middle Aged
  • Pharmaceutical Preparations
  • Pharmacogenomic Testing
  • Precision Medicine
  • Primary Health Care
  • United Kingdom

Keywords

  • clinical pharmacology
  • general practice
  • pharmacogenomics

CYP2E1

DNA methylation and histone acetylation changes to cytochrome P450 2E1 regulation in normal aging and impact on rates of drug metabolism in the liver.


Keywords

  • Aging
  • Cyp2e1
  • DNA methylation
  • Drug metabolism
  • Histone acetylation
  • Pharmacokinetics

CYP7A1

Age-associated changes of cytochrome P450 and related phase-2 gene/proteins in livers of rats.


Keywords

  • Aging
  • Cytochrome P450’s
  • Nuclear receptors
  • Ontogeny
  • Rat liver
  • mRNA/protein expression

DBI

Quantifying cumulative anticholinergic and sedative drug load among US Medicare Beneficiaries.


Keywords

  • aging
  • cholinergic antagonists
  • drug burden index
  • drug utilization
  • hypnotics and sedatives
  • inappropriate prescribing
  • pharmacoepidemiology


Drug Burden Index and Cognitive and Physical Function in Aged Care Residents: A Longitudinal Study.


Keywords

  • Cognitive function
  • anti-muscarinics
  • benzodiazepines
  • geriatrics
  • longitudinal
  • mobility impairment
  • physical function
  • polypharmacy


Using the Drug Burden Index to identify older adults at highest risk for medication-related falls.


Keywords

  • Accidental falls
  • Aging
  • Health services
  • Medication
  • Medication therapy management


Impact of STEADI-Rx: A Community Pharmacy-Based Fall Prevention Intervention.


Keywords

  • aging
  • community pharmacy
  • falls
  • health services
  • medication

DBP

Do baseline blood pressure and type of exercise influence level of reduction induced by training in hypertensive older adults? A meta-analysis of controlled trials.


Keywords

  • Aged
  • Aging
  • Exercise
  • Exercise therapy
  • High blood pressure
  • Hypertension
  • Resistance training


Attenuated aortic blood pressure responses to metaboreflex activation in older adults with dynapenia.


Keywords

  • Aging
  • Diastolic pressure
  • Handgrip strength
  • Post-exercise muscle ischemia
  • Walking performance


The Effect of Blood Pressure on Cognitive Performance. An 8-Year Follow-Up of the Tromsø Study, Comprising People Aged 45-74 Years.


Keywords

  • aging
  • blood pressure
  • cognitive performance
  • dementia
  • sex differences


Low Diastolic Blood Pressure and Cognitive Decline in Korean Elderly People: The Korean Longitudinal Study on Cognitive Aging and Dementia.


Keywords

  • Cognition
  • Diastolic blood pressure
  • Senility


Diastolic Blood Pressure Is Associated With Regional White Matter Lesion Load: The Northern Manhattan Study.


MeSH Terms

  • Aged
  • Arterial Pressure
  • Blood Pressure
  • Brain
  • Cohort Studies
  • Diastole
  • Female
  • Frontal Lobe
  • Humans
  • Hypertension
  • Linear Models
  • Magnetic Resonance Imaging
  • Male
  • Middle Aged
  • Organ Size
  • Parietal Lobe
  • Prospective Studies
  • Systole
  • Temporal Lobe
  • White Matter

Keywords

  • American Heart Association
  • blood pressure
  • cerebrovascular disease
  • cognitive aging
  • white matter


Orthostatic Hypotension and Novel Blood Pressure Associated Gene Variants in Older Adults: Data From the TILDA Study.


Keywords

  • Aging
  • Blood pressure
  • Cardiovascular
  • Genetics
  • Single-nucleotide polymorphism


Blood pressure and hypertension prevalence among oldest-old in China for 16 year: based on CLHLS.


MeSH Terms

  • Aged, 80 and over
  • Blood Pressure
  • Blood Pressure Determination
  • China
  • Female
  • Health Surveys
  • Humans
  • Hypertension
  • Longevity
  • Longitudinal Studies
  • Male
  • Prevalence

Keywords

  • Blood pressure
  • Epidemiology
  • Hypertension
  • Oldest-old
  • Prevalence


The age-related blood pressure trajectories from young-old adults to centenarians: A cohort study.


MeSH Terms

  • Age Factors
  • Aged
  • Aged, 80 and over
  • Aging
  • Blood Pressure
  • Cohort Studies
  • Female
  • Humans
  • Male
  • Middle Aged

Keywords

  • Antihypertensive therapy
  • Birth cohort effect
  • Blood pressure
  • Cohort study
  • Heart disease
  • Survival

DCC

X Chromosome Domain Architecture Regulates Caenorhabditis elegans Lifespan but Not Dosage Compensation.


MeSH Terms

  • Adenosine Triphosphatases
  • Animals
  • Caenorhabditis elegans
  • Caenorhabditis elegans Proteins
  • DNA-Binding Proteins
  • Dosage Compensation, Genetic
  • Gene Expression Regulation
  • Longevity
  • Multiprotein Complexes
  • X Chromosome

Keywords

  • X chromosome dosage compensation
  • aging
  • condensin
  • gene expression
  • higher-order chromosome structure
  • lifespan
  • proteotoxic stress
  • topologically associating domains

DCN

Decorin inhibits the insulin-like growth factor I signaling in bone marrow mesenchymal stem cells of aged humans.


Keywords

  • IGF-I
  • aging
  • bone marrow mesenchymal stem cell
  • osteoporosis
  • small leucine-rich proteoglycan

DCX

GSK-3β activation accelerates early-stage consumption of Hippocampal Neurogenesis in senescent mice.


Keywords

  • Adult hippocampal neurogenesis
  • Glycogen synthase kinase-3β
  • Senescence


Doublecortin and IGF-1R protein levels are reduced in spite of unchanged DNA methylation in the hippocampus of aged rats.


Keywords

  • Aging
  • DNA methylation
  • Doublecortin
  • Hippocampus
  • IGF-1R
  • mGluR5

DDB1

DCAF1 regulates Treg senescence via the ROS axis during immunological aging.


Keywords

  • Aging
  • Cellular senescence
  • Immunology
  • Inflammatory bowel disease
  • T cells

DDC

N-Acetyl Cysteine Attenuates the Sarcopenia and Muscle Apoptosis Induced by Chronic Liver Disease.


MeSH Terms

  • Acetylcysteine
  • Aging
  • Animals
  • Apoptosis
  • Disease Models, Animal
  • End Stage Liver Disease
  • Humans
  • Mice
  • Muscle Fibers, Skeletal
  • Muscular Atrophy
  • Oxidative Stress
  • Pyridines
  • Sarcopenia

Keywords

  • Sarcopenia
  • UPP oxidative stress
  • apoptosis
  • chronic liver disease
  • hepatotoxin.

DDO

New insights on the influence of free d-aspartate metabolism in the mammalian brain during prenatal and postnatal life.


Keywords

  • Brain aging
  • Cell death
  • L-Glutamate
  • NMDA receptors
  • d-Aspartate
  • d-Aspartate oxidase

DDT

Prognostic Value of a Test of Central Auditory Function in Conversion from Mild Cognitive Impairment to Dementia.


Keywords

  • Aging
  • Alzheimer’s disease
  • Auditory processing
  • Cognition
  • Dichotic Digits Test


Uptake kinetics of four hydrophobic organic pollutants in the earthworm Eisenia andrei in aged laboratory-contaminated natural soils.


MeSH Terms

  • Animals
  • DDT
  • Hexachlorocyclohexane
  • Hydrophobic and Hydrophilic Interactions
  • Kinetics
  • Oligochaeta
  • Polychlorinated Biphenyls
  • Pyrenes
  • Soil Pollutants

Keywords

  • Aging
  • BAFs
  • Bioaccumulation
  • HOCs
  • Laboratory-contaminated soils


Adult exposure to insecticides causes persistent behavioral and neurochemical alterations in zebrafish.


Keywords

  • Aging
  • Anxiety-related behavior
  • DDT
  • Neurobehavioral toxicology
  • Zebrafish


Second generation effects of larval metal pollutant exposure on reproduction, longevity and insecticide tolerance in the major malaria vector Anopheles arabiensis (Diptera: Culicidae).


MeSH Terms

  • Animals
  • Anopheles
  • Drug Resistance
  • Female
  • Fertility
  • Insecticides
  • Larva
  • Male
  • Metals
  • Reproduction
  • Water Pollutants

Keywords

  • Anopheles arabiensis
  • Insecticide resistance
  • Longevity
  • Transgenerational effects


Protective effect of Pedro-Ximénez must against p,p'-DDE-induced liver damages in aged Mus spretus mice.


MeSH Terms

  • Aging
  • Animals
  • Antioxidants
  • Chemical and Drug Induced Liver Injury
  • Dichlorodiphenyl Dichloroethylene
  • Down-Regulation
  • Liver
  • Male
  • Mice
  • Oxidative Stress
  • Pesticides
  • Plant Extracts
  • Polyphenols
  • Transcriptome
  • Up-Regulation
  • Vitis

Keywords

  • Aging
  • Hepatoprotection
  • Mus spretus
  • Organochlorine
  • Oxidative damage
  • Pedro-ximénez grape must
  • Transcriptional analysis
  • p,p'-DDE


Low-dose endosulfan inhibits proliferation and induces senescence and pro-inflammatory cytokine production in human lymphocytes, preferentially impacting cytotoxic cells.


MeSH Terms

  • Adult
  • B-Lymphocytes
  • Cell Proliferation
  • Cells, Cultured
  • Cellular Senescence
  • Cytokines
  • Dose-Response Relationship, Drug
  • Endosulfan
  • Female
  • Healthy Volunteers
  • Humans
  • Inflammation Mediators
  • Insecticides
  • Killer Cells, Natural
  • Male
  • Primary Cell Culture
  • T-Lymphocytes, Cytotoxic
  • Young Adult

Keywords

  • Endosulfan
  • Immunosenescence
  • NK cells
  • PBMC
  • cytotoxic cells
  • interferon
  • organochlorine pesticide
  • senescence

DKC1

Successful liver transplantation in short telomere syndromes without bone marrow failure due to DKC1 mutation.


Keywords

  • DKC1
  • cell death: senescence
  • cirrhosis
  • hepatopulmonary syndrome
  • liver transplantation
  • short telomere syndromes

DLD

A preliminary study of cerebral blood flow, aging and dementia in people with Down syndrome.


Keywords

  • Alzheimer's disease
  • Down syndrome
  • aging
  • cerebral blood flow
  • neuroimaging

DLGAP2

Cross-Species Analyses Identify Dlgap2 as a Regulator of Age-Related Cognitive Decline and Alzheimer's Dementia.


Keywords

  • Alzheimer’s
  • Diversity Outbred
  • Dlgap2
  • GWAS
  • aging
  • cognition
  • genetic diversity
  • resilience
  • spines
  • susceptibility
  • translational

DLX5

Inhibition of microRNA-27b-3p relieves osteoarthritis pain via regulation of KDM4B-dependent DLX5.


Keywords

  • adipogenic differentiation
  • cell senescence
  • distal-less homeobox 5
  • lysine demethylase 4B
  • mesenchymal stem cells
  • microRNA-27b-3p
  • osteoarthritis pain
  • osteogenic differentiation

DMD

Aldehyde dehydrogenases contribute to skeletal muscle homeostasis in healthy, aging, and Duchenne muscular dystrophy patients.


Keywords

  • Aging
  • Aldehyde dehydrogenase
  • Dog model
  • Duchenne muscular dystrophy
  • Human
  • Myogenic
  • Non-human primate
  • Skeletal muscle


Life expectancy at birth in Duchenne muscular dystrophy: a systematic review and meta-analysis.


MeSH Terms

  • Female
  • Humans
  • Life Expectancy
  • Male
  • Muscular Dystrophy, Duchenne
  • Parturition
  • Pregnancy
  • Prognosis
  • Quality of Life
  • Respiration, Artificial
  • Survival

Keywords

  • Mechanical ventilation
  • Mortality
  • Prognosis
  • Survival


Renal dysfunction can occur in advanced-stage Duchenne muscular dystrophy.


MeSH Terms

  • Adolescent
  • Adult
  • Aging
  • Child
  • Child, Preschool
  • Cystatin C
  • Disease Progression
  • Female
  • Heart Diseases
  • Heart Function Tests
  • Humans
  • Kidney Diseases
  • Kidney Function Tests
  • Male
  • Muscular Dystrophy, Duchenne
  • Risk Factors
  • Young Adult

Keywords

  • Duchenne muscular dystrophy
  • advanced stage
  • cystatin C
  • ejection fraction
  • fractional shortening
  • renal dysfunction

DNAJB9

DNAJB9 Inhibits p53-Dependent Oncogene-Induced Senescence and Induces Cell Transformation.


Keywords

  • DNAJB9
  • RAS
  • p53
  • senescence
  • transformation

DNMT1

DNA Methyltransferase 1 (DNMT1) Function Is Implicated in the Age-Related Loss of Cortical Interneurons.


Keywords

  • DNA methylation
  • GABA
  • aging
  • cerebral cortex
  • inhibitory interneurons
  • proteostasis
  • synapse
  • transcriptional control

DNMT3A

Epigenetic regulation of miR-29a/miR-30c/DNMT3A axis controls SOD2 and mitochondrial oxidative stress in human mesenchymal stem cells.


Keywords

  • Cellular senescence
  • DNMT3A
  • Human mesenchymal stem cells
  • Mitochondrial oxidative stress
  • SOD2
  • microRNAs


Collagens and DNA methyltransferases in mare endometrosis.


MeSH Terms

  • Aging
  • Animals
  • Collagen
  • DNA (Cytosine-5-)-Methyltransferases
  • DNA Methylation
  • Endometritis
  • Endometrium
  • Female
  • Fibrosis
  • Horse Diseases
  • Horses
  • RNA, Messenger

Keywords

  • DNA methylation
  • collagen
  • endometrium
  • epigenetic
  • fibrosis
  • mare


Age-related clonal haemopoiesis is associated with increased epigenetic age.


MeSH Terms

  • Aged
  • Aged, 80 and over
  • Aging
  • Epigenesis, Genetic
  • Female
  • Hematopoiesis
  • Humans
  • Longitudinal Studies
  • Male
  • Risk Factors
  • Scotland

DNMT3L

Transient DNMT3L Expression Reinforces Chromatin Surveillance to Halt Senescence Progression in Mouse Embryonic Fibroblast.


Keywords

  • DNA methyltransferase 3-like (DNMT3L)
  • chromatin surveillance
  • epigenetics
  • polycomb repressive complex 2 (PRC2)
  • senescence
  • transposable element (TE)

DOCK11

[Immunosenescence: The Forefront of Infection and Trophic Control].


MeSH Terms

  • Aging
  • Animals
  • B-Lymphocytes
  • Cytokinesis
  • Gene Expression
  • Guanine Nucleotide Exchange Factors
  • Humans
  • Immunoglobulin M
  • Immunosenescence
  • Mice
  • Nutritional Status
  • Streptococcus pneumoniae

Keywords

  • B-1a B cell
  • dedicator of cytokinesis 11
  • immunosenescence

DPP4

Age-Dependent Assessment of Genes Involved in Cellular Senescence, Telomere, and Mitochondrial Pathways in Human Lung Tissue of Smokers, COPD, and IPF: Associations With SARS-CoV-2 COVID-19 ACE2-TMPRSS2-Furin-DPP4 Axis.


Keywords

  • DNA damage
  • aging
  • cellular senescence
  • chronic obstructive pulmonary diseases
  • idiopathic pulmonary fibrosis
  • mitochondria
  • smokers
  • telomere


Dipeptidyl peptidase-4 inhibition improves endothelial senescence by activating AMPK/SIRT1/Nrf2 signaling pathway.


Keywords

  • Aging
  • Dipeptidyl peptidase-4
  • Endothelium
  • Oxidative stress
  • Vascular


Molecular crosstalk between Y5 receptor and neuropeptide Y drives liver cancer.


Keywords

  • Aging
  • Cancer
  • Hepatology

DPP6

A novel structure associated with aging is augmented in the DPP6-KO mouse brain.


Keywords

  • Aging dementia
  • Alzheimer’s disease
  • DPP6
  • Presynaptic terminals

DPYSL2

Alcohol drinking exacerbates neural and behavioral pathology in the 3xTg-AD mouse model of Alzheimer's disease.


MeSH Terms

  • Alcohol Drinking
  • Alzheimer Disease
  • Amyloid beta-Protein Precursor
  • Animals
  • Behavior, Animal
  • Brain
  • Disease Models, Animal
  • Mice, Transgenic
  • tau Proteins

Keywords

  • Aging
  • Amyloid beta
  • Ethanol
  • GSK
  • Immunohistochemistry
  • Morris Water Maze
  • Prepulse inhibition
  • Self-administration
  • Tau pathology
  • Transgenic mouse model

DRD1

Impact of dopamine-related genetic variants on physical activity in old age - a cohort study.


MeSH Terms

  • Aged
  • Aged, 80 and over
  • Aging
  • Cohort Studies
  • Exercise
  • Humans
  • Receptors, Dopamine
  • Sedentary Behavior
  • Sweden

Keywords

  • Accelerometery
  • Aging
  • Dopamine
  • Genes
  • Physical activity
  • Sedentary behaviour

DRD2

Cortical thickness mediates the relationship between DRD2 C957T polymorphism and executive function across the adult lifespan.


Keywords

  • Aging
  • Cortical thickness
  • DRD2
  • Dopamine
  • Executive function


The relationship of age and DRD2 polymorphisms to frontostriatal brain activity and working memory performance.


MeSH Terms

  • Aging
  • Brain
  • Humans
  • Memory, Short-Term
  • Polymorphism, Genetic
  • Receptors, Dopamine D2

Keywords

  • Aging
  • C957T
  • DRD2
  • Dopamine
  • Working memory
  • fMRI

DSPP

Effects of [i]p[/i]-Cresol on Senescence, Survival, Inflammation, and Odontoblast Differentiation in Canine Dental Pulp Stem Cells.


Keywords

  • aged teeth
  • apoptosis
  • dental pulp stem cells
  • differentiation
  • pulp regeneration
  • senescence

DST

Ancestral germen/soma distinction in microbes: Expanding the disposable soma theory of aging to all unicellular lineages.


MeSH Terms

  • Aging
  • Animals
  • Biological Evolution
  • DNA Replication
  • Humans
  • Phylogeny

Keywords

  • Aging
  • Asymmetric cell division
  • DNA replication
  • Disposable Soma Theory
  • Epigenetics
  • Evolution
  • Germen/Soma
  • Prokaryotes
  • Protists
  • Rejuvenation
  • Unicellular

DUSP1

miR-1468-3p Promotes Aging-Related Cardiac Fibrosis.


Keywords

  • aging
  • cardiac fibrosis
  • dual-specificity phosphatases
  • extracellular matrix
  • miR-1468-3p
  • microRNA
  • p38
  • senescence

DUSP8

MiR-21-5p/dual-specificity phosphatase 8 signalling mediates the anti-inflammatory effect of haem oxygenase-1 in aged intracerebral haemorrhage rats.


MeSH Terms

  • Aging
  • Animals
  • Antagomirs
  • Anti-Inflammatory Agents
  • Cells, Cultured
  • Cerebral Hemorrhage
  • Dual-Specificity Phosphatases
  • HEK293 Cells
  • Heme Oxygenase-1
  • Hemin
  • Humans
  • Male
  • MicroRNAs
  • Rats
  • Rats, Sprague-Dawley
  • Signal Transduction

Keywords

  • aging
  • dual-specificity phosphatase 8
  • haem oxygenase-1
  • intracerebral haemorrhage
  • microRNA

DUT

Simultaneous liquefaction, saccharification, and fermentation of L-lactic acid using aging paddy rice with hull by an isolated thermotolerant Enterococcus faecalis DUT1805.


Keywords

  • Aging paddy rice with hull (APRH)
  • Corn steep liquor powder (CSLP)
  • High-thermotolerance
  • Lactic acid
  • Saccharification and fermentation (SLSF)
  • Simultaneous liquification

DYRK1A

Altered age-linked regulation of plasma DYRK1A in elderly cognitive complainers (INSIGHT-preAD study) with high brain amyloid load.


Keywords

  • Alzheimer's disease
  • aging
  • blood marker
  • immunometric test

E2F1

Regulation of E2F1 activity via PKA-mediated phosphorylations.


Keywords

  • E2F1
  • PKA
  • cell cycle
  • forskolin
  • proliferation
  • senescence


Astragaloside IV ameliorates radiation-induced senescence via antioxidative mechanism.


Keywords

  • cell signal pathway
  • nerve cells
  • radiation
  • senescence

ECD

Outcome of Descemet Membrane Endothelial Keratoplasty Using Corneas from Donors ≥80 Years of Age.


MeSH Terms

  • Adolescent
  • Adult
  • Aged
  • Aged, 80 and over
  • Aging
  • Cell Count
  • Cornea
  • Descemet Stripping Endothelial Keratoplasty
  • Donor Selection
  • Endothelium, Corneal
  • Female
  • Fuchs' Endothelial Dystrophy
  • Humans
  • Male
  • Middle Aged
  • Retrospective Studies
  • Tissue Donors
  • Treatment Outcome
  • Visual Acuity
  • Young Adult

EDA

Interplay between aging, lung inflammation/remodeling, and fibronectin EDA in lung cancer progression.


Keywords

  • Lung cancer
  • aging
  • fibronectin EDA
  • fibrosis
  • inflammation
  • lewis lung carcinoma
  • metastasis


Arousal Detection in Elderly People from Electrodermal Activity Using Musical Stimuli.


Keywords

  • aging adults
  • arousal
  • electrodermal activity
  • musical genres


The structure of agricultural microplastics (PT, PU and UF) and their sorption capacities for PAHs and PHE derivates under various salinity and oxidation treatments.


MeSH Terms

  • Adsorption
  • Agriculture
  • Ecosystem
  • Environmental Pollutants
  • Hydrogen Peroxide
  • Microplastics
  • Models, Chemical
  • Naphthalenes
  • Organic Chemicals
  • Phenanthrenes
  • Plastics
  • Polycyclic Aromatic Hydrocarbons
  • Polyethylene
  • Polypropylenes
  • Polyurethanes
  • Polyuria
  • Pyrenes
  • Salinity

Keywords

  • Aging
  • Microplastics
  • Polycyclic aromatic hydrocarbons
  • Salinity
  • Sorption

EDARADD

Age prediction in living: Forensic epigenetic age estimation based on blood samples.


MeSH Terms

  • Adolescent
  • Adult
  • Aged
  • Aging
  • Child
  • Child, Preschool
  • CpG Islands
  • Cyclic Nucleotide Phosphodiesterases, Type 4
  • DNA Methylation
  • Edar-Associated Death Domain Protein
  • Fatty Acid Elongases
  • Female
  • Forensic Genetics
  • Humans
  • Infant
  • LIM-Homeodomain Proteins
  • Male
  • Middle Aged
  • Muscle Proteins
  • Polymerase Chain Reaction
  • Transcription Factors
  • Young Adult

Keywords

  • Age the living
  • CpGs
  • DNA methylation age
  • Forensic epigenetics
  • Forensic sciences

EDF1

Silencing of FOREVER YOUNG FLOWER Like Genes from Phalaenopsis Orchids Promotes Flower Senescence and Abscission.


Keywords

         FOREVER YOUNG FLOWER
       
         Phalaenopsis orchids
  • Abscission
  • Ethylene responses
  • MADS-box gene
  • Senescence

EFS

The aging bladder phenotype is not the direct consequence of bladder aging.


MeSH Terms

  • Adrenergic beta-Agonists
  • Aging
  • Animals
  • Carbachol
  • Cholinergic Agonists
  • Electric Stimulation
  • Female
  • Isoproterenol
  • Male
  • Mice
  • Mucous Membrane
  • Muscle Contraction
  • Myography
  • Phenotype
  • Receptor, Muscarinic M3
  • Receptors, Adrenergic, beta-2
  • Urinary Bladder
  • Urination

Keywords

  • aging
  • control physiology
  • resilience
  • urinary dysfunction

EGF

Acute, exercise-induced alterations in cytokines and chemokines in the blood distinguish physically active and sedentary aging.


Keywords

  • growth factors
  • human aging
  • inflammation
  • physical activity


Proinflammation, profibrosis, and arterial aging.


Keywords

  • aging
  • artery
  • collagen
  • profibrosis
  • proinflammation
  • stiffening


Hinokitiol induces cell death and inhibits epidermal growth factor-induced cell migration and signaling pathways in human cervical adenocarcinoma.


Keywords

  • Autophagy
  • Epidermal growth factor
  • Hinokitiol
  • Senescence
  • c-Jun N-Terminal kinase


Activation of epidermal growth factor receptor signaling mediates cellular senescence induced by certain pro-inflammatory cytokines.


Keywords

  • EGFR
  • HUVEC
  • IMR90
  • Ras signaling
  • pro-inflammatory cytokine
  • senescence


Insulin Signaling in Intestinal Stem and Progenitor Cells as an Important Determinant of Physiological and Metabolic Traits in [i]Drosophila[/i].


Keywords

  • ISC
  • fruit fly
  • insulin signaling pathway
  • lifespan
  • metabolism
  • midgut
  • progenitor cells


Different cellular properties and loss of nuclear signalling of porcine epidermal growth factor receptor with aging.


MeSH Terms

  • Animals
  • ErbB Receptors
  • Signal Transduction
  • Swine

Keywords

  • Aging
  • Cell behaviour
  • EGF
  • EGFR
  • Signalling pathway

EGFR

Type I Collagen Aging Increases Expression and Activation of EGFR and Induces Resistance to Erlotinib in Lung Carcinoma in 3D Matrix Model.


Keywords

  • EGFR
  • Erlotinib
  • Type I collagen
  • aging
  • resistance


Comparative effectiveness and cost-effectiveness of three first-line EGFR-tyrosine kinase inhibitors: Analysis of real-world data in a tertiary hospital in Taiwan.


MeSH Terms

  • Afatinib
  • Aged
  • Carcinoma, Non-Small-Cell Lung
  • Cost-Benefit Analysis
  • Erlotinib Hydrochloride
  • Female
  • Gefitinib
  • Humans
  • Life Expectancy
  • Lung Neoplasms
  • Male
  • Propensity Score
  • Protein Kinase Inhibitors
  • Quality of Life
  • Survival Rate
  • Taiwan
  • Tertiary Care Centers


An Optogenetic Method to Study Signal Transduction in Intestinal Stem Cell Homeostasis.


MeSH Terms

  • Animals
  • Cell Communication
  • Cell Proliferation
  • Cells, Cultured
  • Drosophila Proteins
  • Drosophila melanogaster
  • Gene Expression Regulation
  • Gene Regulatory Networks
  • Homeostasis
  • Intestinal Mucosa
  • Light
  • Longevity
  • Optogenetics
  • Signal Transduction
  • Stem Cells

Keywords

  • Drosophila
  • EGFR
  • Toll
  • optogenetics
  • stem cells


Treatment-Induced Tumor Dormancy through YAP-Mediated Transcriptional Reprogramming of the Apoptotic Pathway.


MeSH Terms

  • Adaptor Proteins, Signal Transducing
  • Animals
  • Apoptosis
  • Cell Cycle Proteins
  • Cell Line, Tumor
  • Cell Proliferation
  • Cell Survival
  • Cellular Senescence
  • Drug Resistance, Neoplasm
  • ErbB Receptors
  • Female
  • Gene Deletion
  • Gene Expression Regulation, Neoplastic
  • Humans
  • Lung Neoplasms
  • MAP Kinase Kinase 1
  • Male
  • Mice
  • Mice, Knockout
  • Mutation
  • Signal Transduction
  • Transcription Factors
  • Transcription, Genetic

Keywords

  • YAP
  • dormancy
  • drug resistance
  • drug tolerance
  • epidermal growth factor receptor
  • lung cancer
  • senescence


Association between EGFR mutation and ageing, history of pneumonia and gastroesophageal reflux disease among patients with advanced lung cancer.


MeSH Terms

  • Adult
  • Aged
  • Aged, 80 and over
  • Aging
  • Case-Control Studies
  • ErbB Receptors
  • Female
  • Gastroesophageal Reflux
  • Humans
  • Lung Neoplasms
  • Male
  • Middle Aged
  • Mutation
  • Pneumonia
  • Republic of Korea
  • Retrospective Studies
  • Risk Factors
  • Young Adult

Keywords

  • Ageing
  • EGFR mutation
  • GERD
  • Lung cancer
  • Pneumonia
  • Risk factors

EHF

Extended high frequency hearing and speech perception implications in adults and children.


Keywords

  • Aging
  • Development
  • Extended high frequency audiometry
  • Otitis media
  • Ototoxicity
  • Speech in noise
  • Speech perception
  • Tinnitus

EIF4E

Transcriptomic evidence that insulin signalling pathway regulates the ageing of subterranean termite castes.


MeSH Terms

  • Aging
  • Animals
  • Insulin
  • Isoptera
  • Molecular Sequence Annotation
  • Signal Transduction
  • Transcriptome

ELF3

High Ambient Temperature Accelerates Leaf Senescence via PHYTOCHROME-INTERACTING FACTOR 4 and 5 in [i]Arabidopsis[/i].


Keywords

  • Arabidopsis
  • PIF4
  • phytochrome
  • senescence
  • temperature

ELOVL2

ELOVL2: Not just a biomarker of aging.


Keywords

  • Aging
  • Macular degeneration
  • Membrane structure
  • Polyunsaturated fatty acids


The lipid elongation enzyme ELOVL2 is a molecular regulator of aging in the retina.


MeSH Terms

  • Aging
  • Animals
  • Cell Line
  • DNA Methylation
  • Decitabine
  • Down-Regulation
  • Fatty Acid Elongases
  • Fatty Acids, Unsaturated
  • Female
  • Humans
  • Macular Degeneration
  • Male
  • Mice
  • Mice, Transgenic
  • Point Mutation
  • Promoter Regions, Genetic
  • Retina
  • Retinal Pigment Epithelium

Keywords

  • DNA methylation
  • ELOVL2
  • PUFA
  • age-related macular degeneration
  • aging
  • retina

EN1

Electrochemically detecting DNA methylation in the EN1 gene promoter: implications for understanding ageing and disease.


Keywords

  • Aging
  • biosensor
  • electrochemistry
  • methylation

ENO1

Reduced expression of enolase-1 correlates with high intracellular glucose levels and increased senescence in cisplatin-resistant ovarian cancer cells.


Keywords

  • ENO1
  • Enolase
  • beta-Gal
  • cisplatin resistance
  • glucose
  • ovarian cancer
  • p21
  • p53
  • senescence

ENTPD7

Inhibition of lung cancer cells and Ras/Raf/MEK/ERK signal transduction by ectonucleoside triphosphate phosphohydrolase-7 (ENTPD7).


MeSH Terms

  • Adult
  • Aged
  • Animals
  • Apoptosis
  • Apyrase
  • Biomarkers
  • Cell Line, Tumor
  • Cell Proliferation
  • Cells, Cultured
  • Female
  • Gene Expression Regulation, Neoplastic
  • Gene Silencing
  • Humans
  • Lung Neoplasms
  • MAP Kinase Signaling System
  • Male
  • Mice
  • Mice, Inbred BALB C
  • Mice, Nude
  • Middle Aged
  • Mitogen-Activated Protein Kinases
  • Plasmids
  • Signal Transduction
  • Survival Analysis
  • raf Kinases
  • ras Proteins

Keywords

  • Ectonucleoside triphosphate phosphohydrolase-7
  • Lung cancer
  • Proliferation
  • Senescence

EPO

Regulation of muscle and metabolic physiology by hypothalamic erythropoietin independently of its peripheral action.


Keywords

  • Aging
  • Brain
  • Erythropoietin
  • Glucose tolerance
  • Hypothalamus
  • Metabolism
  • Muscle
  • Obesity


Red Blood Cell Lifespan Shortening in Patients with Early-Stage Chronic Kidney Disease.


MeSH Terms

  • Anemia
  • Erythrocytes
  • Female
  • Humans
  • Male
  • Middle Aged
  • Renal Insufficiency, Chronic

Keywords

  • Chronic kidney disease
  • Erythropoietin
  • Levitt’s CO breath test
  • Red blood cell lifespan
  • Renal anemia

ERCC1

Chronic Sildenafil Treatment Improves Vasomotor Function in a Mouse Model of Accelerated Aging.


Keywords

  • aging
  • cGMP
  • guanylate cyclase
  • hypertension
  • nitric oxide
  • phosphodiesterase
  • sildenafil
  • vascular dysfunction


Local endothelial DNA repair deficiency causes aging-resembling endothelial-specific dysfunction.


MeSH Terms

  • Age Factors
  • Aging
  • Animals
  • Capillary Permeability
  • Cellular Senescence
  • Cyclin-Dependent Kinase Inhibitor p21
  • DNA Damage
  • DNA Repair
  • DNA-Binding Proteins
  • Endonucleases
  • Endothelial Cells
  • Endothelium, Vascular
  • Mice, Inbred C57BL
  • Mice, Knockout
  • Nitric Oxide
  • Nitric Oxide Synthase Type III
  • Superoxides
  • Vascular Stiffness
  • Vasodilation

Keywords

  • DNA damage
  • aging
  • endothelial dysfunction
  • endothelium-dependent dilation
  • nitric oxide


Tissue specificity of senescent cell accumulation during physiologic and accelerated aging of mice.


Keywords

  • DNA repair
  • ERCC1-XPF
  • aging
  • cellular senescence
  • endogenous DNA damage
  • progeria


Deficiency in the DNA repair protein ERCC1 triggers a link between senescence and apoptosis in human fibroblasts and mouse skin.


Keywords

  • DNA damage repair
  • aging
  • cell death
  • senescence-associated secretory phenotype
  • tumor necrosis factor α

ERF

Angiotensin-Converting Enzyme Gene D/I Polymorphism in Relation to Endothelial Function and Endothelial-Released Factors in Chinese Women.


Keywords

  • ACE D/I gene polymorphism
  • Chinese women
  • aging
  • endothelial function
  • endothelial-released factors
  • menopause


Projections of Ambient Temperature- and Air Pollution-Related Mortality Burden Under Combined Climate Change and Population Aging Scenarios: a Review.


Keywords

  • Air pollution
  • Climate change
  • Mortality
  • Population aging
  • Projection
  • Temperature


Exome Sequencing Analysis Identifies Rare Variants in [i]ATM[/i] and [i]RPL8[/i] That Are Associated With Shorter Telomere Length.


Keywords

  • ATM
  • RPL8
  • aging
  • meta-analysis
  • telomere
  • whole exome sequencing

ERG

Effect of age and sex on neurodevelopment and neurodegeneration in the healthy eye: Longitudinal functional and structural study in the Long-Evans rat.


Keywords

  • Aging
  • Electroretinography
  • Neurodegeneration
  • Neurodevelopment
  • Optical coherence tomography
  • Retina
  • Sex


Mice With a Combined Deficiency of Superoxide Dismutase 1 (Sod1), DJ-1 (Park7), and Parkin (Prkn) Develop Spontaneous Retinal Degeneration With Aging.


MeSH Terms

  • Aging
  • Animals
  • Biomarkers
  • Electroretinography
  • Enzyme-Linked Immunosorbent Assay
  • Immunohistochemistry
  • Malondialdehyde
  • Mice
  • Mice, Inbred C57BL
  • Mice, Knockout
  • Microscopy, Electron, Transmission
  • Mitochondria
  • Oxidative Stress
  • Protein Deglycase DJ-1
  • Retina
  • Retinal Degeneration
  • Retinal Pigment Epithelium
  • Superoxide Dismutase-1
  • Tomography, Optical Coherence
  • Ubiquitin-Protein Ligases

ESPL1

Identification and genomic analysis of pedigrees with exceptional longevity identifies candidate rare variants.


Keywords

  • Genomics
  • Longevity
  • Pedigree
  • Rare variant sharing
  • Utah population database

ETS1

The transcription factor ETS1 promotes apoptosis resistance of senescent cholangiocytes by epigenetically up-regulating the apoptosis suppressor BCL2L1.


MeSH Terms

  • ATP Binding Cassette Transporter, Subfamily B
  • Animals
  • Apoptosis
  • Cellular Senescence
  • Hepatocytes
  • Humans
  • Lipopolysaccharides
  • Liver
  • Mice
  • Proto-Oncogene Protein c-ets-1
  • Transcription Factors
  • bcl-X Protein

Keywords

  • BCL2 like 1 (BCL2L1)
  • apoptosis
  • cholangiocyte
  • chromatin modification
  • epigenetics
  • gene expression
  • primary sclerosing cholangitis (PSC)
  • senescence
  • transcription factor

EVL

Health Years in Total: A New Health Objective Function for Cost-Effectiveness Analysis.


MeSH Terms

  • Cost-Benefit Analysis
  • Health Care Costs
  • Health Status
  • Health Status Indicators
  • Humans
  • Life Expectancy
  • Quality of Life
  • Quality-Adjusted Life Years
  • Time Factors

Keywords

  • cost-effectiveness
  • equal value of life
  • health years in total
  • quality-adjusted life-year
  • thresholds

EZH2

Linking gene expression and phenotypic changes in the developmental and evolutionary origins of osteosclerosis in the ribs of bowhead whales (Balaena mysticetus).


Keywords

  • Cetacea
  • aging
  • bone
  • hyperostosis
  • osteoblasts
  • whales


EZH2 is involved in vulnerability to neuroinflammation and depression-like behaviors induced by chronic stress in different aged mice.


Keywords

  • Aging
  • CUMS
  • Cytokines
  • Depresion
  • EZH2
  • Microglia


A positive feedback loop between EZH2 and NOX4 regulates nucleus pulposus cell senescence in age-related intervertebral disc degeneration.


Keywords

  • Epigenetic histone modification
  • Intervertebral disc degeneration
  • Nucleus pulposus cell senescence
  • Wnt/β-catenin signaling pathway


Perinatal exposure to bisphenol A impacts in the mammary gland morphology of adult Mongolian gerbils.


MeSH Terms

  • Actins
  • Aging
  • Animals
  • Benzhydryl Compounds
  • Cell Proliferation
  • Collagen
  • Enhancer of Zeste Homolog 2 Protein
  • Female
  • Gerbillinae
  • Histones
  • Mammary Glands, Animal
  • Phenols
  • Pregnancy
  • Prenatal Exposure Delayed Effects

Keywords

  • BPA
  • EZH2
  • Environment pollutant
  • Estrogen
  • Morphologic alterations
  • Phospho-histone-h3

F2

Environmental risk assessment of glufosinate-resistant soybean by pollen-mediated gene flow under field conditions in the region of the genetic origin.


Keywords

  • Glufosinate resistance
  • Relative fitness
  • Seed longevity
  • Transgene flow
  • Weed risk


Gestational arsenite exposure augments hepatic tumors of C3H mice by promoting senescence in F1 and F2 offspring via different pathways.


Keywords

  • Arsenic
  • Liver
  • Multigenerational Effect
  • SASP
  • Senescence
  • Tumor


Familial Longevity is Associated with an Attenuated Thyroidal Response to Recombinant Human Thyroid Stimulating Hormone.


Keywords

  • Thyroid
  • longevity
  • recombinant human TSH
  • responsivity


Conclusions from a behavioral aging study on male and female F2 hybrid mice on age-related behavior, buoyancy in water-based tests, and an ethical method to assess lifespan.


MeSH Terms

  • Adiposity
  • Aging
  • Animals
  • Exploratory Behavior
  • Female
  • Male
  • Memory
  • Mice, Inbred BALB C
  • Mice, Inbred C57BL
  • Swimming

Keywords

  • F2 hybrid mice
  • aging
  • exploratory activity
  • sex comparison
  • water-based behavioral tests


In utero exposure to acetaminophen and ibuprofen leads to intergenerational accelerated reproductive aging in female mice.


MeSH Terms

  • Acetaminophen
  • Aging
  • Animals
  • Animals, Newborn
  • Cell Proliferation
  • Female
  • Fertility
  • Forkhead Box Protein O3
  • Germ Cells
  • Ibuprofen
  • Luteolysis
  • Mice
  • Ovary
  • Pregnancy
  • Prenatal Exposure Delayed Effects
  • Proto-Oncogene Proteins c-akt
  • Reproduction
  • Signal Transduction

Keywords

  • Infertility
  • Oogenesis
  • Risk factors

F3

A Comprehensive Analysis of Age and Gender Effects in European Portuguese Oral Vowels.


Keywords

  • Acoustic
  • Aging voice
  • European Portuguese
  • Oral vowel


Prenatal exposure to an environmentally relevant phthalate mixture accelerates biomarkers of reproductive aging in a multiple and transgenerational manner in female mice.


Keywords

  • cyclicity
  • hormone
  • mixture
  • ovary
  • phthalates
  • reproductive aging
  • transgenerational


Combining Frontal Transcranial Direct Current Stimulation With Walking Rehabilitation to Enhance Mobility and Executive Function: A Pilot Clinical Trial.


Keywords

  • Aging
  • cognition
  • rehabilitation
  • transcranial direct current stimulation
  • walking


Multigenerational exposure to TiO nanoparticles in soil stimulates stress resistance and longevity of survived C. elegans via activating insulin/IGF-like signaling.


MeSH Terms

  • Animals
  • Caenorhabditis elegans
  • Caenorhabditis elegans Proteins
  • Insulin
  • Longevity
  • Nanoparticles
  • Oxidative Stress
  • Soil
  • Titanium

Keywords

  • Insulin/IGF-like signaling
  • Longevity
  • Multigenerational toxicity
  • Nanomaterial
  • Soil nematode


Co-expression network analysis identified hub genes critical to triglyceride and free fatty acid metabolism as key regulators of age-related vascular dysfunction in mice.


MeSH Terms

  • Aging
  • Animals
  • Fatty Acids, Nonesterified
  • Gene Expression Profiling
  • Gene Expression Regulation
  • Gene Regulatory Networks
  • Lipid Metabolism
  • Mice
  • Microarray Analysis
  • Signal Transduction
  • Triglycerides
  • Vascular Diseases

Keywords

  • aging
  • co-expression network
  • hub gene
  • module
  • mouse
  • vascular dysfunction

F5

Methylation signatures in peripheral blood are associated with marked age acceleration and disease progression in patients with primary sclerosing cholangitis.


Keywords

  • ALP, alkaline phosphatase
  • ALT, alanine aminotransferase
  • Aging
  • BMI, body mass index
  • DNAm, DNA methylation
  • ELF, enhanced liver fibrosis
  • FDR, false discovery rate
  • GGT, gamma-glutamyltransferase
  • IBD, inflammatory bowel disease
  • IL, interleukin
  • LOXL2, lysyl oxidase-like-2
  • NASH, non-alcoholic steatohepatitis
  • PSC, primary sclerosing cholangitis
  • SMA, smooth muscle actin
  • UDCA, ursodeoxycholic acid
  • biomarker
  • inflammatory bowel disease
  • primary sclerosing cholangitis
  • prognosis
  • ursodeoxycholic acid


Fermentation of Blackberry with [i]L. plantarum[/i] JBMI F5 Enhance the Protection Effect on UVB-Mediated Photoaging in Human Foreskin Fibroblast and Hairless Mice through Regulation of MAPK/NF-κB Signaling.


MeSH Terms

  • Animals
  • Cell Line
  • Cell Survival
  • Female
  • Fermentation
  • Fibroblasts
  • Foreskin
  • Fruit
  • Lactobacillus plantarum
  • Male
  • Mice
  • Mice, Hairless
  • Plant Extracts
  • Rubus
  • Skin Aging
  • Ultraviolet Rays

Keywords

  • Lactobacillus plantarum
  • MMPs
  • fermented blackberry
  • photoaging
  • skin aging
  • type I procollagen

F7

The Pattern of Mu Rhythm Modulation During Emotional Destination Memory: Comparison Between Mild Cognitive Impairment Patients and Healthy Controls.


MeSH Terms

  • Aged
  • Aging
  • Cognitive Dysfunction
  • Electroencephalography
  • Emotions
  • Female
  • Frontal Lobe
  • Humans
  • Male
  • Memory
  • Neurophysiological Monitoring
  • Neuropsychological Tests
  • Task Performance and Analysis
  • Temporal Lobe

Keywords

  • Emotional destination memory
  • Mu suppression
  • fronto-temporal
  • mild cognitive impairment
  • mirror neurons

FAAH

Endocannabinoid genetic variation enhances vulnerability to THC reward in adolescent female mice.


MeSH Terms

  • Aging
  • Amidohydrolases
  • Animals
  • Axons
  • Choice Behavior
  • Dronabinol
  • Endocannabinoids
  • Female
  • Genetic Variation
  • Male
  • Mice, Inbred C57BL
  • Nerve Net
  • Nucleus Accumbens
  • Polymorphism, Single Nucleotide
  • Receptor, Cannabinoid, CB1
  • Reward
  • Tyrosine 3-Monooxygenase
  • Ventral Tegmental Area

FABP3

FABP3-mediated membrane lipid saturation alters fluidity and induces ER stress in skeletal muscle with aging.


MeSH Terms

  • Aging
  • Animals
  • Cell Line
  • Endoplasmic Reticulum Stress
  • Eukaryotic Initiation Factor-2
  • Fatty Acid Binding Protein 3
  • Female
  • Gene Knockdown Techniques
  • Lipidomics
  • Membrane Fluidity
  • Membrane Lipids
  • Mice, Inbred C57BL
  • Mice, Knockout
  • Muscle, Skeletal
  • Myoblasts
  • Phospholipids
  • Protein-Serine-Threonine Kinases
  • Sarcopenia
  • Up-Regulation


Autophagy receptor OPTN (optineurin) regulates mesenchymal stem cell fate and bone-fat balance during aging by clearing FABP3.


Keywords

  • Adipogenesis
  • autophagy
  • bone metabolism
  • fabp3
  • mesenchymal stem cell
  • optineurin
  • osteogenesis
  • osteoporosis
  • senescence


Myokines as biomarkers of frailty and cardiovascular disease risk in females.


Keywords

  • Aging
  • Biomarkers
  • Cardiovascular disease
  • Females
  • Frailty
  • Myokines

FADS1

Aging and FADS1 polymorphisms decrease the biosynthetic capacity of long-chain PUFAs: A human trial using [U- C]linoleic acid.


MeSH Terms

  • Adult
  • Age Factors
  • Aged
  • Aging
  • Alleles
  • Arachidonic Acid
  • Area Under Curve
  • Fatty Acid Desaturases
  • Fatty Acids, Unsaturated
  • Female
  • Healthy Volunteers
  • Humans
  • Linoleic Acid
  • Male
  • Polymorphism, Single Nucleotide

Keywords

  • Aging
  • Arachidonic acid
  • Fatty acid conversion
  • Linoleic acid
  • Lipid metabolism
  • Long-chain polyunsaturated fatty acid

FANCD2

TFG-maintaining stability of overlooked FANCD2 confers early DNA-damage response.


Keywords

  • DNA damage response
  • FANCD2
  • TFG
  • aging and cancer

FAP

Rapamycin Extends Life Span in Apc Colon Cancer FAP Model.


Keywords

  • Aging
  • Crypt stem cells
  • eEF2K
  • mTORC1
  • rpS6


Exercise enhances skeletal muscle regeneration by promoting senescence in fibro-adipogenic progenitors.


MeSH Terms

  • Aging
  • Animals
  • Apoptosis
  • Exercise Therapy
  • Female
  • Humans
  • Mesenchymal Stem Cells
  • Mice
  • Mice, Inbred BALB C
  • Mice, Inbred C57BL
  • Muscle, Skeletal
  • Muscular Diseases
  • Regeneration


Control of Muscle Fibro-Adipogenic Progenitors by Myogenic Lineage is Altered in Aging and Duchenne Muscular Dystrophy.


MeSH Terms

  • Adipogenesis
  • Adolescent
  • Adult
  • Adult Stem Cells
  • Aged
  • Aging
  • Cells, Cultured
  • Child
  • Child, Preschool
  • Female
  • Humans
  • Infant
  • Male
  • Middle Aged
  • Muscle Development
  • Muscular Dystrophy, Duchenne
  • Myoblasts
  • Young Adult

Keywords Adipocytes; Myofibroblasts; Muscle progenitors; Myopathies

FAS

Five-year change in maximum tongue pressure and physical function in community-dwelling elderly adults.


Keywords

  • Aging
  • Biological age
  • Elderly
  • Physical function
  • Tongue pressure


Inhibition of USP7 activity selectively eliminates senescent cells in part via restoration of p53 activity.


Keywords

  • MDM2
  • Senescence
  • USP7
  • apoptosis
  • p53
  • senolytics

FES

An outpatient Tai Chi program: Effects on veterans' functional outcomes.


Keywords

  • Tai Chi
  • balance
  • exercise
  • gait
  • geriatrics


Gait Function in Adults Aged 50 Years and Older With Spina Bifida.


Keywords

  • Adult
  • Aging
  • Gait analysis
  • Myelomeningocele
  • Rehabilitation


A Single Question as a Screening Tool to Assess Fear of Falling in Young-Old Community-Dwelling Persons.


Keywords

  • FES-I
  • elderly
  • fear of falling
  • healthy aging
  • older adults


Fall-related efficacy is a useful and independent index to detect fall risk in Japanese community-dwelling older people: a 1-year longitudinal study.


MeSH Terms

  • Accidental Falls
  • Activities of Daily Living
  • Aged
  • Aging
  • Female
  • Geriatric Assessment
  • Humans
  • Independent Living
  • Japan
  • Longitudinal Studies
  • Male
  • Physical Functional Performance
  • Postural Balance
  • Risk Factors
  • Walking Speed

Keywords

  • Accidental falls
  • Aged
  • Fall-related efficacy
  • Japanese
  • Physical performance


Investigating Changes in Real-time Conscious Postural Processing by Older Adults during Different Stance Positions Using Electroencephalography Coherence.


MeSH Terms

  • Accidental Falls
  • Aged
  • Aging
  • Brain
  • Electroencephalography
  • Fear
  • Female
  • Humans
  • Male
  • Movement
  • Postural Balance
  • Posture

FEV

Prediction of Lung Function in Adolescence Using Epigenetic Aging: A Machine Learning Approach.


Keywords

  • epigenetic aging
  • feature selection
  • hyperparameter tuning
  • lung function
  • machine learning


Effect of Age on the Efficacy and Safety of Once-Daily Single-Inhaler Triple Therapy Fluticasone Furoate/Umeclidinium/Vilanterol in Patients With Chronic Obstructive Pulmonary Disease: A Post Hoc Analysis of the IMPACT Trial.


Keywords

  • COPD
  • aging
  • exacerbations
  • safety
  • single-inhaler triple therapy


A comprehensive analysis of factors related to lung function in older adults: Cross-sectional findings from the Canadian Longitudinal Study on Aging.


Keywords

  • Aging
  • Determinants
  • Lung function
  • Sex
  • Spirometry


Risk factors associated with the detection of pulmonary emphysema in older asymptomatic respiratory subjects.


Keywords

  • Aging
  • COPD
  • Klotho
  • Pulmonary emphysema
  • Risk factors
  • Telomere length


Tiotropium Respimat Efficacy and Safety in Asthma: Relationship to Age.


Keywords

  • Aging
  • Asthma
  • Long-acting muscarinic antagonist
  • Long-acting β(2)-agonists
  • Pharmacotherapy


Current Bronchodilator Responsiveness Criteria Underestimate Asthma in Older Adults.


Keywords

  • aging
  • albuterol
  • asthma
  • bronchodilator effect
  • lung diseases
  • older adult
  • spirometry


Physical performances show conflicting associations in aged manual workers.


MeSH Terms

  • Aged
  • Aging
  • Body Composition
  • Body Mass Index
  • Cardiorespiratory Fitness
  • Cross-Sectional Studies
  • Hand Strength
  • Humans
  • Lung
  • Male
  • Middle Aged
  • Physical Functional Performance


FEV as a Standalone Spirometric Predictor and the Attributable Fraction for Death in Older Persons.


Keywords

  • aging
  • average attributable fraction
  • death
  • relative risk
  • spirometry


An Individualized Prediction Model for Long-term Lung Function Trajectory and Risk of COPD in the General Population.


MeSH Terms

  • Adult
  • Age Factors
  • Aging
  • Alcohol Drinking
  • Algorithms
  • Alkaline Phosphatase
  • Body Height
  • Bronchodilator Agents
  • Cigarette Smoking
  • Cohort Studies
  • Cough
  • Dyspnea
  • Electrocardiography
  • Female
  • Forced Expiratory Volume
  • Hematocrit
  • Humans
  • Leukocyte Count
  • Longitudinal Studies
  • Lung
  • Machine Learning
  • Male
  • Middle Aged
  • Pulmonary Disease, Chronic Obstructive
  • Risk Assessment
  • Serum Albumin
  • Serum Globulins
  • Sex Factors
  • Spirometry
  • Triglycerides
  • Vital Capacity

Keywords

  • COPD
  • FEV(1)
  • FEV(1)/FVC
  • airflow limitation
  • lung function
  • predictive modeling


Telomere length and lung function in a population-based cohort of children and mid-life adults.


MeSH Terms

  • Aged
  • Asthma
  • Body Mass Index
  • Child
  • Cohort Studies
  • Cross-Sectional Studies
  • Exercise
  • Female
  • Forced Expiratory Volume
  • Humans
  • Lung
  • Male
  • Respiratory Function Tests
  • Risk Factors
  • Smoking
  • Spirometry
  • Telomere
  • Vital Capacity

Keywords

  • aging
  • cell senescence
  • life course
  • national cohort
  • spirometry

FGA

Goal Pursuit, Goal Adjustment, and Pain in Middle-Aged Adults Aging With Physical Disability.


MeSH Terms

  • Adaptation, Psychological
  • Aged
  • Aging
  • Depression
  • Disabled Persons
  • Female
  • Goals
  • Humans
  • Male
  • Middle Aged
  • Multiple Sclerosis
  • Muscular Dystrophies
  • Pain
  • Postpoliomyelitis Syndrome
  • Spinal Cord Injuries

Keywords

  • aging
  • disability
  • goal management
  • pain
  • psychological adaptation


Tenacious Goal Pursuit, Flexible Goal Adjustment, and Life Satisfaction Among Chinese Older Adult Couples.


Keywords

  • flexible goal adjustment
  • life satisfaction
  • older couples
  • self-perceptions of aging
  • tenacious goal pursuit

FGF19

Bile acid receptor agonists in primary biliary cholangitis: Regulation of the cholangiocyte secretome and downstream T cell differentiation.


Keywords

  • FGF19
  • FXR
  • TGR5
  • autoimmunity
  • senescence

FGF2

The influence of fibroblast growth factor 2 on the senescence of human adipose-derived mesenchymal stem cells during long-term culture.


Keywords

  • cell proliferation
  • cellular senescence
  • fibroblast growth factor 2
  • long-term culture
  • mesenchymal stem cell

FGF21

Differential effects of sulfur amino acid-restricted and low-calorie diets on gut microbiome profile and bile acid composition in male C57BL6/J mice.


Keywords

  • Clostridales
  • firmicutes
  • lifespan
  • methionine restriction
  • sulfur metabolism


Relationship between physical activity and circulating fibroblast growth factor 21 in middle-aged and older adults.


Keywords

  • Accelerometer
  • Activity intensity
  • Aging
  • FGF21
  • Physical activity


Exercise and dietary intervention ameliorate high-fat diet-induced NAFLD and liver aging by inducing lipophagy.


Keywords

  • Aging
  • Exercise
  • FGF21
  • Lipophagy
  • Nonalcoholic fatty liver disease (NAFLD)


Mitochondria, immunosenescence and inflammaging: a role for mitokines?


Keywords

  • Human ageing
  • Immunosenescence
  • Inflammaging
  • Mitochondrial metabolism
  • Mitokines


Age-at-onset-dependent effects of sulfur amino acid restriction on markers of growth and stress in male F344 rats.


Keywords

  • ER stress
  • cysteine
  • glutathione
  • hormesis
  • lifespan
  • methionine
  • trade-offs
  • translational


Fibroblast growth factor 21 prolongs lifespan and improves stress tolerance in the silkworm, [i]Bombyx mori[/i].


Keywords

  • Bombyx mori
  • fibroblast growth factor 21 (FGF21)
  • lifespan
  • oxidation resistance
  • stress tolerance


Neurogenesis and prolongevity signaling in young germ-free mice transplanted with the gut microbiota of old mice.


MeSH Terms

  • Animals
  • Butyrates
  • Fecal Microbiota Transplantation
  • Fibroblast Growth Factors
  • Gastrointestinal Microbiome
  • Germ-Free Life
  • Hippocampus
  • Intestines
  • Liver
  • Longevity
  • Male
  • Metabolome
  • Mice, Inbred C57BL
  • Microtubule-Associated Proteins
  • Neurogenesis
  • Neurons
  • Neuropeptides
  • Phenotype
  • Proton Magnetic Resonance Spectroscopy


Fibroblast Growth Factor 21 Mediates the Associations between Exercise, Aging, and Glucose Regulation.


MeSH Terms

  • Adiponectin
  • Adult
  • Aging
  • Blood Glucose
  • Blood Pressure
  • Body Mass Index
  • Diabetes Mellitus, Type 2
  • Exercise
  • Female
  • Fibroblast Growth Factors
  • Glucose Tolerance Test
  • Humans
  • Insulin
  • Lipids
  • Male
  • Middle Aged
  • Risk Factors


Effects of Moderate Chronic Food Restriction on the Development of Postprandial Dyslipidemia with Ageing.


MeSH Terms

  • Adiposity
  • Aging
  • Animals
  • Basic Helix-Loop-Helix Leucine Zipper Transcription Factors
  • Blood Glucose
  • Diet, Fat-Restricted
  • Dietary Fats
  • Disease Models, Animal
  • Dyslipidemias
  • Glucagon
  • Insulin
  • Lipids
  • Liver
  • Metabolic Syndrome
  • Postprandial Period
  • Rats
  • Rats, Wistar
  • Triglycerides

Keywords

  • ChREBP
  • adipose tissue
  • ageing
  • oral lipid loading test
  • postprandial hypertrigliceridemia
  • postprandial thermogenesis

FGF23

Phosphate as a Pathogen of Arteriosclerosis and Aging.


Keywords

  • Aging
  • Calciprotein particles (CPPs)
  • Fibroblast growth factor-23 (FGF23)
  • Inflammation
  • Klotho
  • Phosphate
  • Vascular calcification


Plasma Soluble αKlotho, Serum Fibroblast Growth Factor 23, and Mobility Disability in Community-Dwelling Older Adults.


Keywords

  • aging
  • chronic kidney disease
  • fibroblast growth factor 23
  • mobility disability
  • αKlotho


Protective effect of Polygonatum sibiricum Polysaccharide on D-galactose-induced aging rats model.


MeSH Terms

  • Aging
  • Animals
  • Calcium
  • Dietary Carbohydrates
  • Fibroblast Growth Factors
  • Galactose
  • Glucuronidase
  • Male
  • Oxidative Stress
  • Phosphorus
  • Phytochemicals
  • Polygonatum
  • Polysaccharides
  • Protective Agents
  • Rats
  • Rats, Sprague-Dawley


FGF23 expression is stimulated in transgenic α-Klotho longevity mouse model.


MeSH Terms

  • Aldosterone
  • Animals
  • Bone and Bones
  • Cardiovascular Diseases
  • Disease Models, Animal
  • Female
  • Fibroblast Growth Factors
  • Gene Knockout Techniques
  • Glucuronidase
  • Kidney
  • Longevity
  • Male
  • Mice
  • Mice, Inbred C57BL
  • Mice, Transgenic
  • Osteoblasts
  • Protein Isoforms
  • Transcriptome

Keywords

  • Bone Biology
  • Cardiovascular disease


Fibroblast growth factor 23 and symmetric dimethylarginine concentrations in geriatric cats.


MeSH Terms

  • Aging
  • Animals
  • Arginine
  • Biomarkers
  • Cats
  • Cross-Sectional Studies
  • Female
  • Fibroblast Growth Factors
  • Male
  • Reference Values
  • Retrospective Moral Judgment

Keywords

  • azotemia
  • feline
  • phosphate
  • renal

FGFR1

Alignment of Alzheimer's disease amyloid β-peptide and klotho.


Keywords

  • Alzheimer’s disease
  • HSV-1
  • aging
  • alignment
  • klotho
  • neurodegeneration
  • neuroinflammation
  • protein
  • ubiquitin
  • β-amyloid


Satellite cell-specific ablation of Cdon impairs integrin activation, FGF signalling, and muscle regeneration.


Keywords

  • Cdon
  • Cellular senescence
  • FGFR
  • Growth factor signalling
  • Muscle regeneration
  • Satellite cell

FGFR4

FGFR4 Inhibitor BLU9931 Attenuates Pancreatic Cancer Cell Proliferation and Invasion While Inducing Senescence: Evidence for Senolytic Therapy Potential in Pancreatic Cancer.


Keywords

  • FGFR4
  • FGFR4 inhibitor
  • growth
  • invasion
  • pancreatic cancer
  • senescence
  • senolytic therapy

FGR

Aurora kinase mRNA expression is reduced with increasing gestational age and in severe early onset fetal growth restriction.


Keywords

  • Aurora kinase
  • Cellular senescence
  • FGR
  • Preeclampsia

FH

Genetic Factors of Alzheimer's Disease Modulate How Diet is Associated with Long-Term Cognitive Trajectories: A UK Biobank Study.


Keywords

  • APOE4
  • Aging
  • Mediterranean diet
  • cognitive decline
  • functional food
  • lamb
  • nutrition policy
  • preventive medicine
  • red wine
  • salt


Volumetric alterations in the hippocampal subfields of subjects at increased risk of dementia.


MeSH Terms

  • Adult
  • Aging
  • Alzheimer Disease
  • Apolipoproteins E
  • Atrophy
  • Dementia
  • Diffusion Magnetic Resonance Imaging
  • Educational Status
  • Female
  • Genotype
  • Hippocampus
  • Humans
  • Male
  • Middle Aged
  • Organ Size
  • Risk

Keywords

  • Alzheimer's disease
  • Dementia
  • Hippocampal subfields
  • Hippocampus
  • Preclinical dementia


Macroscopic hematuria as a risk factor for hypertension in ageing people with hemophilia and a family history of hypertension.


MeSH Terms

  • Adult
  • Aged
  • Aged, 80 and over
  • Aging
  • Cross-Sectional Studies
  • Female
  • Hematuria
  • Hemophilia A
  • Humans
  • Hypertension
  • Israel
  • Logistic Models
  • Male
  • Middle Aged
  • Risk Factors


LDL Receptor Deficiency Does not Alter Brain Amyloid-β Levels but Causes an Exacerbation of Apoptosis.


MeSH Terms

  • Aging
  • Amyloid beta-Protein Precursor
  • Animals
  • Apoptosis
  • Brain Chemistry
  • Caspase 3
  • Cholesterol
  • Gene Expression
  • Hippocampus
  • Male
  • Maze Learning
  • Mice
  • Mice, Inbred C57BL
  • Mice, Knockout
  • Prefrontal Cortex
  • Receptors, LDL

Keywords

  • Familial hypercholesterolemia
  • LDLr-/- mice
  • amyloid-β
  • apoptosis
  • memory impairment

FNDC5

Irisin Correlates Positively With BMD in a Cohort of Older Adult Patients and Downregulates the Senescent Marker p21 in Osteoblasts.


Keywords

  • BONE-MUSCLE INTERACTIONS
  • IRISIN
  • OSTEOPOROSIS
  • SARCOPENIA
  • SENESCENCE


[Investigation of signal molecules in saliva: prospects of application for diagnostics of myocardial infarction and the aging rate of different age people.]


MeSH Terms

  • Aged
  • Aging
  • Biomarkers
  • Cytokines
  • Humans
  • Middle Aged
  • Myocardial Infarction
  • Saliva
  • Tumor Necrosis Factor-alpha

Keywords

  • aging
  • diagnosis
  • myocardial infarction
  • saliva
  • signaling molecules

FOS

Muscle atrophy-related myotube-derived exosomal microRNA in neuronal dysfunction: Targeting both coding and long noncoding RNAs.


Keywords

  • HIF-1α-AS2
  • aging
  • lncRNAs
  • miR-29b-3p
  • muscle atrophy

FOSL2

LncRNA GUARDIN suppresses cellular senescence through a LRP130-PGC1α-FOXO4-p21-dependent signaling axis.


Keywords

GUARDIN

  • LRP130-PGC1α
  • cellular senescence
  • lncRNAs
  • p21

FOXA1

Analyses of an epigenetic switch involved in the activation of pioneer factor FOXA1 leading to the prognostic value of estrogen receptor and FOXA1 co-expression in breast cancer.


MeSH Terms

  • Breast Neoplasms
  • Down-Regulation
  • Epigenesis, Genetic
  • Female
  • Gene Expression Regulation, Neoplastic
  • Hepatocyte Nuclear Factor 3-alpha
  • Humans
  • Middle Aged
  • Prognosis
  • RNA, Messenger
  • Receptor, ErbB-2
  • Receptors, Estrogen
  • Receptors, Progesterone
  • Transcriptome
  • Up-Regulation

Keywords

  • FOXA1
  • age-related diseases
  • aging
  • breast cancer
  • hormone receptor
  • methylation
  • prognosis

FOXM1

Sirtuin 6 deficiency induces endothelial cell senescence via downregulation of forkhead box M1 expression.


Keywords

  • FOXM1
  • SIRT6
  • cell cycle
  • endothelial cell
  • senescence

FOXN1

Thymic rejuvenation via FOXN1-reprogrammed embryonic fibroblasts (FREFs) to counteract age-related inflammation.


Keywords

  • Aging
  • Immunology
  • Immunotherapy
  • T cell development

FOXO1

l-Theanine attenuates liver aging by inhibiting advanced glycation end products in d-galactose-induced rats and reversing an imbalance of oxidative stress and inflammation.


Keywords

  • AGEs
  • Inflammatory response
  • Liver aging
  • Oxidative stress
  • l-Theanine

FOXO3

The DNA methylation of FOXO3 and TP53 as a blood biomarker of late-onset asthma.


Keywords

  • Aging
  • DNA methylation
  • FOXO3
  • Late-onset asthma
  • TP53


FOXO3 targets are reprogrammed as Huntington's disease neural cells and striatal neurons face senescence with p16 increase.


Keywords

  • neurodegenerative disease
  • neuronal differentiation
  • neuronal senescence
  • response mechanisms
  • temporal dynamics


Astaxanthin as a Putative Geroprotector: Molecular Basis and Focus on Brain Aging.


Keywords

  • FOXO3
  • NRF2
  • SIRT1
  • astaxanthin
  • geroprotector
  • longevity
  • neuroprotection


Inflamma-miR-21 Negatively Regulates Myogenesis during Ageing.


Keywords

  • IL6
  • IL6R
  • aging
  • cachexia
  • miR-21
  • microRNA
  • muscle
  • regeneration
  • sarcopenia


Variable DNA methylation of aging-related genes is associated with male COPD.


MeSH Terms

  • Adolescent
  • Adult
  • Age Factors
  • Aged
  • Aged, 80 and over
  • Aging
  • Case-Control Studies
  • CpG Islands
  • DNA Methylation
  • Databases, Genetic
  • Female
  • Forced Expiratory Volume
  • Forkhead Transcription Factors
  • Genetic Predisposition to Disease
  • Humans
  • Lung
  • Male
  • Middle Aged
  • Pulmonary Disease, Chronic Obstructive
  • Risk Assessment
  • Risk Factors
  • Severity of Illness Index
  • Sex Factors
  • Transcriptome
  • Vital Capacity
  • Young Adult

Keywords

  • Aging
  • Aging-related genes
  • COPD
  • DNA methylation


A conserved role of the insulin-like signaling pathway in diet-dependent uric acid pathologies in Drosophila melanogaster.


MeSH Terms

  • Animals
  • Animals, Genetically Modified
  • Cohort Studies
  • Disease Models, Animal
  • Drosophila melanogaster
  • Feeding Behavior
  • Female
  • Gene Knockdown Techniques
  • Gout
  • Humans
  • Insulin
  • Kidney Calculi
  • Longevity
  • Male
  • Metabolic Networks and Pathways
  • Middle Aged
  • NADPH Oxidases
  • Polymorphism, Single Nucleotide
  • Purines
  • Signal Transduction
  • Urate Oxidase
  • Uric Acid

FOXO4

FOXO4-DRI alleviates age-related testosterone secretion insufficiency by targeting senescent Leydig cells in aged mice.


Keywords

  • FOXO4-DRI
  • Leydig cell
  • male late-onset hypogonadism
  • senescence
  • senolytics

FOXP1

GATA6 regulates aging of human mesenchymal stem/stromal cells.


Keywords

  • aging
  • cell signaling
  • mesenchymal stem cells
  • reprogramming
  • transcription factors

FSHR

FSHR ablation induces depression-like behaviors.


Keywords

  • FSH
  • ROS
  • aging
  • antioxidants
  • depression
  • metabolism


Direct actions of gonadotropins beyond the reproductive system and their role in human aging and neoplasia [Bezpośrednie działanie gonadotropin poza układem rozrodczym i ich rola w starzeniu się i nowotworzeniu u człowieka].


MeSH Terms

  • Aging
  • Female
  • Gonadotropin-Releasing Hormone
  • Gonadotropins
  • Humans
  • Hypothalamo-Hypophyseal System
  • Luteinizing Hormone
  • Male
  • Receptors, FSH
  • Receptors, LH

Keywords

  • aging
  • folitropin
  • lutropin
  • neoplasia

FTO

Decreased expression of m A demethylase FTO in ovarian aging.


Keywords

  • Epigenetics
  • FTO
  • Ovarian aging
  • Ovarian reserve
  • m6A

FYN

An inhibitor role of Nrf2 in the regulation of myocardial senescence and dysfunction after myocardial infarction.


MeSH Terms

  • Animals
  • Cardiomyopathies
  • Cellular Senescence
  • Echocardiography
  • Gene Silencing
  • Male
  • Mice
  • Mice, Inbred C57BL
  • Mice, Knockout
  • Myocardial Infarction
  • Myocardium
  • Myocytes, Cardiac
  • NF-E2-Related Factor 2
  • RNA, Small Interfering
  • Ventricular Remodeling

Keywords

  • Cellular senescence
  • Myocardial infarction
  • Nrf2
  • Oxidative stress

G6PD

G6PD overexpression protects from oxidative stress and age-related hearing loss.


Keywords

  • ARHL
  • NADPH
  • TrxR
  • aging
  • glutathione


The Sickle Effect: The Silent Titan Affecting Glycated Hemoglobin Reliability.


Keywords

  • diabetes
  • genetics
  • glycosylated hemoglobin
  • hba1c
  • hbas
  • race
  • rbc lifespan
  • sickle cell trait


DNA damage and synaptic and behavioural disorders in glucose-6-phosphate dehydrogenase-deficient mice.


MeSH Terms

  • Animals
  • Brain
  • DNA Breaks, Double-Stranded
  • DNA Breaks, Single-Stranded
  • DNA Damage
  • Disease Models, Animal
  • Enzyme Activation
  • Female
  • Glucosephosphate Dehydrogenase
  • Glucosephosphate Dehydrogenase Deficiency
  • Male
  • Mental Disorders
  • Mice
  • Oxidation-Reduction
  • Purkinje Cells

Keywords

  • 8-Oxo-2′-deoxyguanine (8-oxodG)
  • Aging
  • Behavioural disorders
  • Comet
  • DNA damage
  • Electrophysiology
  • Gamma-H2AX (γH2AX)
  • Glucose-6-phosphate dehydrogenase (G6PD)
  • Lifespan
  • Neurodegeneration
  • Reactive oxygen species (ROS)

GAA

Mitochondrial damage and senescence phenotype of cells derived from a novel frataxin G127V point mutation mouse model of Friedreich's ataxia.


Keywords

  • Frataxin
  • Friedreich's ataxia
  • Mitochondria
  • Oxidative stress
  • Point mutation
  • Senescence


Age-Related Changes in Serum Guanidinoacetic Acid in Women.


MeSH Terms

  • Adolescent
  • Adult
  • Aged
  • Aging
  • Biomarkers
  • Energy Metabolism
  • Exercise
  • Female
  • Glycine
  • Humans
  • Independent Living
  • Middle Aged
  • Young Adult

GABARAP

Age-dependent loss of adipose Rubicon promotes metabolic disorders via excess autophagy.


MeSH Terms

  • Adipocytes
  • Adipogenesis
  • Adipose Tissue
  • Adiposity
  • Aging
  • Animals
  • Apoptosis Regulatory Proteins
  • Autophagy
  • Fatty Liver
  • Gene Knockout Techniques
  • Glucose
  • HEK293 Cells
  • Humans
  • Intracellular Signaling Peptides and Proteins
  • Lipid Metabolism
  • Metabolic Diseases
  • Mice
  • Mice, Inbred C57BL
  • Mice, Knockout
  • Microtubule-Associated Proteins
  • Nuclear Receptor Coactivator 1
  • Nuclear Receptor Coactivator 2
  • PPAR gamma

GAL

Overexpression of Pitx1 attenuates the senescence of chondrocytes from osteoarthritis degeneration cartilage-A self-controlled model for studying the etiology and treatment of osteoarthritis.


Keywords

  • Osteoarthritis
  • Pitx1
  • Senescence
  • Sirt1


β-Caryophyllene Reduces DNA Oxidation and the Overexpression of Glial Fibrillary Acidic Protein in the Prefrontal Cortex and Hippocampus of d-Galactose-Induced Aged BALB/c Mice.


MeSH Terms

  • Aging
  • Animals
  • Antioxidants
  • DNA Damage
  • Disease Models, Animal
  • Galactose
  • Glial Fibrillary Acidic Protein
  • Hippocampus
  • Male
  • Mice
  • Mice, Inbred BALB C
  • Neuroprotection
  • Oxidative Stress
  • Polycyclic Sesquiterpenes
  • Prefrontal Cortex

Keywords

  • CB2 receptor agonist
  • biological aging
  • cognitive flexibility
  • phytocannabinoid
  • β-caryophyllene

GAP43

HDAC inhibition leads to age-dependent opposite regenerative effect upon PTEN deletion in rubrospinal axons after SCI.


MeSH Terms

  • Aging
  • Animals
  • Axons
  • GAP-43 Protein
  • Gene Deletion
  • Gene Expression
  • Histone Deacetylase Inhibitors
  • Histone Deacetylases
  • Hydroxamic Acids
  • Mice, Transgenic
  • Motor Activity
  • Nerve Regeneration
  • PTEN Phosphohydrolase
  • Recovery of Function
  • Spinal Cord
  • Spinal Cord Injuries

Keywords

  • Aging
  • Epigenetics
  • Histone deacetylase
  • Pten
  • Regeneration
  • Spinal cord injury

GATA4

Epigenetics and Vascular Senescence-Potential New Therapeutic Targets?


Keywords

  • calcification
  • cell senescence
  • epigenetics
  • inflammation
  • oxidation stress
  • vascular aging


Prolonged treatment with Y-27632 promotes the senescence of primary human dermal fibroblasts by increasing the expression of IGFBP-5 and transforming them into a CAF-like phenotype.


Keywords

  • IGFBP-5
  • Rho kinase inhibitor
  • Y-27632
  • dermal fibroblast
  • senescence

GBA

Reduced sphingolipid hydrolase activities, substrate accumulation and ganglioside decline in Parkinson's disease.


MeSH Terms

  • Aged
  • Aging
  • Female
  • Glucosylceramidase
  • Humans
  • Hydrolases
  • Lysosomes
  • Male
  • Mutation
  • Parkinson Disease
  • Risk Factors
  • Substantia Nigra
  • alpha-Synuclein

Keywords

  • Ageing
  • Ganglioside
  • Glucocerebrosidase
  • Glycosphingolipid
  • Lysosome
  • Neurodegeneration
  • Parkinson’s disease

GC

Body Size and Cuticular Hydrocarbons as Larval Age Indicators in the Forensic Blow Fly, Chrysomya albiceps (Diptera: Calliphoridae).


Keywords

         Chrysomya albiceps
       
  • body size
  • cuticular hydrocarbon
  • forensic
  • larval longevity


Composition of peony petal fatty acids and flavonoids and their effect on Caenorhabditis elegans lifespan.


Keywords

  • Caenorhabditis elegans
  • Fatty acid
  • Flavonoid identification and composition
  • Lifespan extension
  • Tree peony petal


Photo aging and fragmentation of polypropylene food packaging materials in artificial seawater.


Keywords

  • Aging
  • Antioxidant
  • Food packaging materials
  • Microplastics
  • Polypropylene
  • seawater


Secretory galectin-3 induced by glucocorticoid stress triggers stemness exhaustion of hepatic progenitor cells.


Keywords

  • AMP-activated kinase (AMPK)
  • Cell senescence
  • cell cycle
  • cellular senescence
  • galectin
  • galectin-3
  • glycoprotein
  • liver injury
  • proliferation
  • protein interaction
  • protein-protein interaction
  • quiescence
  • stem cells
  • stemness exhaustion


Optimization of Ethanol Detection by Automatic Headspace Method for Cellulose Insulation Aging of Oil-immersed Transformers.


Keywords

  • aging
  • cellulose insulation
  • gas chromatography
  • headspace sampling


Sensory, olfactometric and chemical characterization of the aroma potential of Garnacha and Tempranillo winemaking grapes.


MeSH Terms

  • Fruit
  • Gas Chromatography-Mass Spectrometry
  • Hexanols
  • Norisoprenoids
  • Odorants
  • Olfactometry
  • Principal Component Analysis
  • Sulfhydryl Compounds
  • Vitis
  • Volatile Organic Compounds

Keywords

  • Aging
  • Aroma precursors
  • Glycosides
  • Lipid-derived aroma
  • Norisoprenoids
  • Sensory properties
  • Terpenols
  • Volatile phenols


Accelerated Cognitive Ageing in epilepsy: exploring the effective connectivity between resting-state networks and its relation to cognitive decline.


Keywords

  • Accelerated cognitive ageing
  • Ageing
  • Aging
  • Biomarkers
  • Clinical research
  • Cognition
  • Cognitive decline
  • Cognitive neuroscience
  • Effective connectivity
  • Epilepsy
  • Fmri
  • Granger causality
  • Image processing
  • Medical imaging
  • Mental health
  • Nervous system
  • Neuroscience
  • Psychiatry


Characterization of Jinhua ham aroma profiles in specific to aging time by gas chromatography-ion mobility spectrometry (GC-IMS).


Keywords

  • Aging
  • Electronic-nose
  • Gas chromatography-ion mobility spectrometry
  • Jinhua ham
  • Volatiles


Quantitative Profiling of Lipid Species in Caenorhabditis elegans with Gas Chromatography-Mass Spectrometry.


Keywords

  • Aging
  • C. elegans
  • Fat
  • Fatty acids
  • Gas chromatography–mass spectrometry
  • Lipids
  • Phospholipids
  • Solid-phase chromatography
  • Triglycerides


Physicochemical characterization of a polysaccharide from Agrocybe aegirita and its anti-ageing activity.


MeSH Terms

  • Aging
  • Agrocybe
  • Antioxidants
  • Carbohydrate Sequence
  • Cell Line
  • Chemical Phenomena
  • G1 Phase Cell Cycle Checkpoints
  • Humans
  • Membrane Potential, Mitochondrial
  • Mitochondria
  • Polysaccharides

Keywords

  • Agrocybe aegirita polysaccharide
  • Anti-ageing
  • Cell cycle
  • Mitochondrial membrane potential
  • Structure


Structural characteristics, antioxidant properties and antiaging activities of galactan produced by Mentha haplocalyx Briq.


MeSH Terms

  • Aging
  • Animals
  • Antioxidants
  • Biphenyl Compounds
  • Carbohydrate Conformation
  • Galactans
  • Male
  • Mentha
  • Mice
  • Mice, Inbred Strains
  • Particle Size
  • Picrates
  • Surface Properties

Keywords

  • Anti-aging activity
  • Antioxidant activity
  • Mentha haplocalyx Briq
  • Polysaccharides


Contribution of Volatile Odorous Terpenoid Compounds to Aged Cognac Spirits Aroma in a Context of Multicomponent Odor Mixtures.


Keywords

  • Cognac
  • aging aroma
  • lees
  • monoterpenes
  • perceptual synergic effects


Plasma Formate Is Greater in Fetal and Neonatal Rats Compared with Their Mothers.


MeSH Terms

  • Aging
  • Animals
  • Animals, Newborn
  • Female
  • Fetus
  • Formates
  • Liver
  • Maternal-Fetal Exchange
  • Mothers
  • Placenta
  • Pregnancy
  • Rats
  • Rats, Sprague-Dawley

Keywords

  • fetus
  • glycine
  • methionine
  • mitochondria
  • one-carbon metabolism
  • pregnancy
  • serine
  • tetrahydrofolate


Development of a new strategy for studying the aroma potential of winemaking grapes through the accelerated hydrolysis of phenolic and aromatic fractions (PAFs).


Keywords

  • Aging
  • Glycosidic precursors
  • Grape aroma
  • Grape quality
  • Hydrolysis
  • Polyphenols
  • Wine


Compromised steady-state germinal center activity with age in nonhuman primates.


MeSH Terms

  • Aging
  • Animals
  • Antigens, CD
  • B-Lymphocytes
  • CD4-Positive T-Lymphocytes
  • CD8-Positive T-Lymphocytes
  • Forkhead Transcription Factors
  • Germinal Center
  • Granulocytes
  • Immunity, Humoral
  • Inflammation
  • Lymph Nodes
  • Macaca mulatta
  • Monocytes

Keywords

  • B cells
  • Tfh cells
  • aging
  • follicles


Endogenous Glucocorticoid Signaling in the Regulation of Bone and Marrow Adiposity: Lessons from Metabolism and Cross Talk in Other Tissues.


MeSH Terms

  • Adipose Tissue
  • Adiposity
  • Animals
  • Bone Marrow
  • Energy Metabolism
  • Glucocorticoids
  • Homeostasis
  • Humans
  • Liver
  • Muscle, Skeletal
  • Receptor Cross-Talk
  • Receptors, Glucocorticoid
  • Signal Transduction
  • Stress, Physiological

Keywords

  • Adipocyte
  • Aging
  • Bone marrow
  • Corticosterone
  • Cortisol
  • Cortisone
  • Glucocorticoid
  • Osteoblast


4,5-Diphenyl-2-methyl picolinate induces cellular senescence by accumulating DNA damage and activating associated signaling pathways in gastric cancer.


MeSH Terms

  • Animals
  • Antineoplastic Agents
  • Apoptosis
  • Cell Cycle
  • Cell Proliferation
  • Cellular Senescence
  • DNA Damage
  • Humans
  • Mice
  • Mice, Inbred BALB C
  • Mice, Nude
  • Picolinic Acids
  • Signal Transduction
  • Stomach Neoplasms
  • Tumor Cells, Cultured
  • Xenograft Model Antitumor Assays

Keywords

  • Cellular senescence
  • DNA damage
  • Gastric cancer
  • N-heterocyclic compound


Relationship Between the Dose Administered, Target Tissue Dose, and Toxicity Level After Acute Oral Exposure to Bifenthrin and Tefluthrin in Young Adult Rats.


MeSH Terms

  • Administration, Oral
  • Aging
  • Animals
  • Body Temperature
  • Cerebellum
  • Cyclopropanes
  • Dose-Response Relationship, Drug
  • Hydrocarbons, Fluorinated
  • Liver
  • Male
  • Pyrethrins
  • Rats
  • Rats, Wistar
  • Tissue Distribution
  • Toxicokinetics

Keywords

  • acute effects
  • bifenthrin
  • body temperature
  • disposition
  • rat
  • tefluthrin


Sugar Beet Pectin Supplementation Did Not Alter Profiles of Fecal Microbiota and Exhaled Breath in Healthy Young Adults and Healthy Elderly.


MeSH Terms

  • Aged
  • Beta vulgaris
  • Breath Tests
  • Dietary Supplements
  • Double-Blind Method
  • Exhalation
  • Fatty Acids, Volatile
  • Feces
  • Female
  • Gastrointestinal Microbiome
  • Healthy Volunteers
  • Humans
  • Male
  • Pectins
  • Volatile Organic Compounds
  • Young Adult

Keywords

  • aging
  • dietary fiber
  • elderly
  • exhaled air
  • microbiota
  • pectin
  • young adults


Identification and analysis of new α- and β-hydroxy ketones related to the formation of 3-methyl-2,4-nonanedione in musts and red wines.


MeSH Terms

  • Alkanes
  • Diacetyl
  • Ethanol
  • Fruit and Vegetable Juices
  • Gas Chromatography-Mass Spectrometry
  • Humans
  • Hydrogen-Ion Concentration
  • Ketones
  • Limit of Detection
  • Solid Phase Microextraction
  • Stereoisomerism
  • Time Factors
  • Wine

Keywords

  • 3-methyl-2,4-nonanedione
  • Aroma precursor
  • Hydroxy ketones
  • Oxidation
  • Premature aging
  • Wine


Neonatal T Follicular Helper Cells Are Lodged in a Pre-T Follicular Helper Stage Favoring Innate Over Adaptive Germinal Center Responses.


MeSH Terms

  • Adaptive Immunity
  • Adjuvants, Immunologic
  • Aging
  • Animals
  • Animals, Newborn
  • Germinal Center
  • Immunity, Innate
  • Interleukin-13
  • Lymphopoiesis
  • Mice, Inbred C57BL
  • T-Lymphocytes, Helper-Inducer
  • Th2 Cells
  • Transcriptome

Keywords

  • T follicular helper cells
  • adjuvant
  • neonates
  • transcriptional profile analysis
  • vaccines


Identification of Dialkylpyrazines Off-Flavors in Oak Wood.


MeSH Terms

  • Flavoring Agents
  • Gas Chromatography-Mass Spectrometry
  • Odorants
  • Olfactometry
  • Pyrazines
  • Quercus
  • Wood

Keywords

  • aroma
  • barrel aging
  • dialkylpyrazine
  • oak wood
  • off-flavor
  • wine


Metabolomics Coupled with Transcriptomics Approach Deciphering Age Relevance in Sepsis.


Keywords

  • aging
  • biomarker
  • metabolomics
  • sepsis
  • transcriptomics

GCA

Familial aggregation of longevity in giant cell arteritis and polymyalgia rheumatica.


Keywords

  • Giant cell arteritis
  • Longevity
  • Mortality
  • Polymyalgia rheumatica


Interaction between Alcohol Consumption and Apolipoprotein E (ApoE) Genotype with Cognition in Middle-Aged Men.


Keywords

  • Aging
  • Alcohol drinking
  • Apolipoprotein E4 (ApoE)
  • Cognitive abilities
  • Male
  • Middle aged
  • Risk factors

GCK

The Impact of Biomarker Screening and Cascade Genetic Testing on the Cost-Effectiveness of MODY Genetic Testing.


MeSH Terms

  • Biomarkers
  • Child
  • Cost-Benefit Analysis
  • Diabetes Mellitus, Type 2
  • Female
  • Genetic Testing
  • Health Care Costs
  • Humans
  • Life Expectancy
  • Male
  • Mass Screening
  • Pedigree
  • Precision Medicine
  • Quality-Adjusted Life Years

GCLC

Aerobic exercise training partially reverses the impairment of Nrf2 activation in older humans.


Keywords

  • Aging
  • Exercise
  • GCLC
  • NQO1
  • Nrf2 signaling
  • Redox homeostasis

GCLM

Silencing Bach1 alters aging-related changes in the expression of Nrf2-regulated genes in primary human bronchial epithelial cells.


MeSH Terms

  • Adult
  • Aged
  • Aging
  • Basic-Leucine Zipper Transcription Factors
  • Bronchi
  • Epithelial Cells
  • Gene Expression
  • Gene Silencing
  • Glutamate-Cysteine Ligase
  • Heme Oxygenase-1
  • Humans
  • Isothiocyanates
  • Middle Aged
  • NAD(P)H Dehydrogenase (Quinone)
  • NF-E2-Related Factor 2
  • RNA, Messenger
  • RNA, Small Interfering
  • Signal Transduction
  • Young Adult

Keywords

  • Aging
  • Bach1
  • Glutamate cysteine ligase
  • Heme oxygenase
  • Nrf2
  • Sulforaphane

GDF11

Growth differentiation factor-11 supplementation improves survival and promotes recovery after ischemic stroke in aged mice.


Keywords

  • GDF11
  • White matter integrity
  • aging
  • gliosis
  • stroke


Anti-Aging Effects of GDF11 on Skin.


Keywords

  • disease
  • growth factors
  • regeneration
  • skin aging


Targeted Approach to Distinguish and Determine Absolute Levels of GDF8 and GDF11 in Mouse Serum.


Keywords

  • GDF11
  • aging
  • immunoprecipitation
  • myostatin/GDF8
  • serum
  • targeted-quantitative proteomics


Growth differentiation factor 11 impairs titanium implant healing in the femur and leads to mandibular bone loss.


Keywords

  • aging
  • alveolar bone loss
  • dental implants
  • osseointegration
  • transforming growth factors


Systemic GDF11 stimulates the secretion of adiponectin and induces a calorie restriction-like phenotype in aged mice.


Keywords

  • GDF11
  • adiponectin
  • aging
  • calorie restriction
  • heterochronic parabiosis
  • rejuvenation


Circulating factors in young blood as potential therapeutic agents for age-related neurodegenerative and neurovascular diseases.


MeSH Terms

  • Age Factors
  • Aging
  • Animals
  • Blood
  • Bone Morphogenetic Proteins
  • Chemokine CCL11
  • Enzyme Therapy
  • Enzymes
  • Growth Differentiation Factors
  • Mice
  • Neurodegenerative Diseases
  • Parabiosis
  • Vascular Diseases

Keywords

  • C-C motif chemokine 11
  • Circulating factor
  • Growth differentiation factor 11
  • Neurodegenerative diseases
  • Neurovascular diseases
  • Young blood


Effects of Exercise Training on Growth and Differentiation Factor 11 Expression in Aged Mice.


Keywords

  • aging
  • exercise
  • growth and differentiation factor 11
  • sarcopenia
  • skeletal muscle

GDF15

Disease-specific plasma levels of mitokines FGF21, GDF15, and Humanin in type II diabetes and Alzheimer's disease in comparison with healthy aging.


Keywords

  • AD
  • Aging
  • FGF21
  • GDF15
  • Humanin
  • T2D


Growth differentiation factor 15 protects against the aging-mediated systemic inflammatory response in humans and mice.


Keywords

  • T cell
  • aging
  • inflammation
  • mitochondria
  • senescence


Analysis of Epigenetic Age Predictors in Pain-Related Conditions.


Keywords

  • DNA methylation
  • aging biomarker
  • chronic pain
  • epigenetic aging
  • epigenetic clock
  • fibromyalgia
  • headache
  • pain sensitivity


GDF15 Plasma Level Is Inversely Associated With Level of Physical Activity and Correlates With Markers of Inflammation and Muscle Weakness.


Keywords

  • GDF15
  • healthy aging
  • inflammation
  • physical activity
  • sedentarity
  • skeletal muscle


GDF15 is an epithelial-derived biomarker of idiopathic pulmonary fibrosis.


MeSH Terms

  • Aged
  • Alveolar Epithelial Cells
  • Animals
  • Bleomycin
  • Bronchoalveolar Lavage Fluid
  • Case-Control Studies
  • Disease Models, Animal
  • Female
  • Gene Expression Profiling
  • Growth Differentiation Factor 15
  • Humans
  • Idiopathic Pulmonary Fibrosis
  • Lung
  • Male
  • Mice
  • Middle Aged
  • Respiratory Function Tests
  • Severity of Illness Index
  • Survival Analysis
  • Telomere
  • Transcriptome

Keywords

  • MIC-1
  • NAG-1
  • SASP
  • aging


Senescence-associated tissue microenvironment promotes colon cancer formation through the secretory factor GDF15.


MeSH Terms

  • Aging
  • Cells, Cultured
  • Cellular Senescence
  • Colonic Neoplasms
  • Fibroblasts
  • Growth Differentiation Factor 15
  • HEK293 Cells
  • Humans
  • Phenotype
  • RNA, Messenger
  • Tumor Microenvironment

Keywords

  • GDF15
  • colon organoids
  • colorectal cancer
  • microenvironment
  • senescence

GDF5

An embryonic CaVβ1 isoform promotes muscle mass maintenance via GDF5 signaling in adult mouse.


MeSH Terms

  • Adult
  • Aged
  • Aged, 80 and over
  • Aging
  • Animals
  • Atrophy
  • Calcium Channels, L-Type
  • Denervation
  • Embryo, Mammalian
  • Exons
  • Female
  • Gene Expression Regulation, Developmental
  • Growth Differentiation Factor 5
  • Humans
  • Male
  • Mice
  • Muscles
  • Neuromuscular Junction
  • Organ Size
  • Physical Conditioning, Animal
  • Protein Isoforms
  • RNA Splicing
  • Signal Transduction
  • Young Adult

GDNF

GFR-α1 Expression in Substantia Nigra Increases Bilaterally Following Unilateral Striatal GDNF in Aged Rats and Attenuates Nigral Tyrosine Hydroxylase Loss Following 6-OHDA Nigrostriatal Lesion.


MeSH Terms

  • Aging
  • Animals
  • Dopamine
  • Glial Cell Line-Derived Neurotrophic Factor
  • Glial Cell Line-Derived Neurotrophic Factor Receptors
  • Neurons
  • Oxidopamine
  • Phosphorylation
  • Rats
  • Substantia Nigra
  • Tyrosine 3-Monooxygenase

Keywords

  • 6-hydroxydopamine
  • Parkinson’s disease
  • Substantia nigra
  • aging
  • nigrostriatal
  • tyrosine hydroxylase

GEM

The Impact of Geriatric Emergency Management Nurses on the Care of Frail Older Patients in the Emergency Department: a Systematic Review.


Keywords

  • emergency department
  • geriatric emergency management nurses
  • geriatrics

GFAP

Immunohistological Detection of Active Satellite Cellsin Rat Dorsal Root Ganglia after Parenteral Administration of Lipopolysaccharide and during Aging.


Keywords

  • aging
  • dorsal root ganglion
  • satellite cells
  • systemic inflammation


Transgenic Mice Expressing Human α-Synuclein in Noradrenergic Neurons Develop Locus Ceruleus Pathology and Nonmotor Features of Parkinson's Disease.


Keywords

  • Parkinson's disease
  • aging
  • locus ceruleus
  • nonmotor
  • norepinephrine
  • α-synuclein


ApoE Genotype-Dependent Response to Antioxidant and Exercise Interventions on Brain Function.


Keywords

  • Alzheimer’s disease
  • ApoE
  • aging
  • antioxidants
  • cognition
  • exercise
  • motor
  • oxidative stress
  • vitamin C
  • vitamin E


Age-Dependent Heterogeneity of Murine Olfactory Bulb Astrocytes.


Keywords

  • Sholl analysis
  • aging
  • astrocyte
  • cell morphology
  • heterogeneity
  • olfactory bulb


Neuroinflammation in Aged Brain: Impact of the Oral Administration of Ellagic Acid Microdispersion.


Keywords

  • CD45
  • EA microdispersion (EAm)
  • GFAP
  • aging
  • behavioral skills
  • ellagic acid (EA)
  • mice
  • noradrenaline
  • oral administration
  • principal component analysis (PCA)


Long-term treatment with spermidine increases health span of middle-aged Sprague-Dawley male rats.


Keywords

  • Autophagy
  • Behavior
  • Longevity
  • Middle-aged rats
  • Neuroinflammation
  • Spermidine


Meta-analysis of human prefrontal cortex reveals activation of GFAP and decline of synaptic transmission in the aging brain.


Keywords

  • Aging
  • Meta-analysis
  • Prefrontal cortex
  • Sex-specific
  • Transcriptome


Astroglial biotin deprivation under endoplasmic reticulum stress uncouples BCAA-mTORC1 role in lipid synthesis to prolong autophagy inhibition in the aging brain.


Keywords

  • BCAA
  • ER stress
  • aging
  • autophagy
  • lipogenesis
  • mTORC1


Long-lived mice with reduced growth hormone signaling have a constitutive upregulation of hepatic chaperone-mediated autophagy.


Keywords

  • Aging
  • chaperone-mediated autophagy
  • endocrine control of autophagy
  • endocrine signaling
  • growth hormone


Lipopolysaccharide exposure during late embryogenesis triggers and drives Alzheimer-like behavioral and neuropathological changes in CD-1 mice.


Keywords

  • Alzheimer's disease
  • aging
  • lipopolysaccharide
  • memory
  • mice


Increased levels of Aβ42 decrease the lifespan of ob/ob mice with dysregulation of microglia and astrocytes.


MeSH Terms

  • Alzheimer Disease
  • Amyloid beta-Peptides
  • Animals
  • Astrocytes
  • Gene Knock-In Techniques
  • Longevity
  • Mice
  • Mice, Knockout
  • Mice, Obese
  • Microglia
  • Peptide Fragments

Keywords

  • Alzheimer's disease
  • astrocytes
  • diabetes
  • lifespan
  • microglia
  • obesity


Selective brain neuronal and glial losses without changes in GFAP immunoreactivity: Young versus mature adult Wistar rats.


MeSH Terms

  • Aging
  • Animals
  • Brain
  • Glial Fibrillary Acidic Protein
  • Male
  • Neuroglia
  • Neurons
  • Rats
  • Rats, Wistar

Keywords

  • Ageing
  • Astrocytes
  • GFAP
  • Glia
  • Neurons

GGCT

Blockade of γ-Glutamylcyclotransferase Enhances Docetaxel Growth Inhibition of Prostate Cancer Cells.


MeSH Terms

  • Antineoplastic Agents
  • Apoptosis
  • Cell Line, Tumor
  • Cell Proliferation
  • Cellular Senescence
  • Docetaxel
  • Enzyme Inhibitors
  • Gene Expression
  • Humans
  • Immunohistochemistry
  • Male
  • Prostatic Neoplasms
  • RNA, Small Interfering
  • gamma-Glutamylcyclotransferase

Keywords

  • docetaxel
  • pro-GA
  • prostate cancer cells
  • senescence
  • γ-glutamylcyclotransferase

GHR

Tissue-Specific GHR Knockout Mice: An Updated Review.


Keywords

  • aging
  • growth hormone
  • longevity
  • metabolism
  • mice

GHRH

Physiological and metabolic features of mice with CRISPR/Cas9-mediated loss-of-function in growth hormone-releasing hormone.


Keywords

  • CRISPR
  • GHRH
  • aging
  • lifespan
  • metabolism


Transcriptomic and metabolomic profiling of long-lived growth hormone releasing hormone knock-out mice: evidence for altered mitochondrial function and amino acid metabolism.


Keywords

  • aging
  • growth hormone
  • metabolite
  • mouse
  • transcriptomics

GIP

Absence of GIP secretion alleviates age-related obesity and insulin resistance.


MeSH Terms

  • Adiponectin
  • Adipose Tissue
  • Age Factors
  • Animals
  • Diet
  • Diet, High-Fat
  • Enteroendocrine Cells
  • Gastric Inhibitory Polypeptide
  • Gene Expression
  • Glucose Tolerance Test
  • Insulin
  • Insulin Resistance
  • Leptin
  • Male
  • Mice, Inbred C57BL
  • Mice, Knockout
  • Mice, Transgenic
  • Obesity

Keywords

  • GIP
  • aging
  • incretin
  • obesity

GIT2

Multidimensional informatic deconvolution defines gender-specific roles of hypothalamic GIT2 in aging trajectories.


MeSH Terms

  • Aging
  • Animals
  • Cluster Analysis
  • Computational Biology
  • Female
  • GTPase-Activating Proteins
  • Hypothalamus
  • Longevity
  • Male
  • Mice
  • Mice, Inbred C57BL
  • RNA
  • Sex Characteristics
  • Signal Transduction
  • Transcriptome

Keywords

  • Aging
  • Female
  • GIT2
  • Hypothalamus
  • Longevity

GJC2

Zebrafish brain RNA sequencing reveals that cell adhesion molecules are critical in brain aging.


Keywords

  • Brain aging
  • Cell adhesion molecules
  • RNA sequencing
  • Zebrafish

GK

Progression of diabetic kidney disease in T2DN rats.


MeSH Terms

  • Aging
  • Albuminuria
  • Animals
  • Blood Glucose
  • Diabetes Mellitus, Type 2
  • Diabetic Nephropathies
  • Disease Progression
  • Hypertrophy
  • Kidney Glomerulus
  • Male
  • Membrane Proteins
  • Organ Size
  • Polyuria
  • Rats
  • Rats, Wistar
  • Renin-Angiotensin System
  • Water-Electrolyte Imbalance

Keywords

  • diabetic glomerular disease
  • diabetic nephropathy
  • podocyte pathology
  • renin-angiotensin-aldosterone system
  • scanning ion microscopy
  • type 2 diabetic nephropathy

GNAQ

GNAQ expression initiated in multipotent neural crest cells drives aggressive melanoma of the central nervous system.


MeSH Terms

  • Aging
  • Animals
  • Central Nervous System Neoplasms
  • Disease Models, Animal
  • Disease Progression
  • Embryonic Development
  • Female
  • GTP-Binding Protein alpha Subunits, Gq-G11
  • Male
  • Melanocytes
  • Melanoma
  • Meningeal Neoplasms
  • Mice, Transgenic
  • Multipotent Stem Cells
  • Mutation
  • Neoplasm Invasiveness
  • Neural Crest
  • Nevus
  • Skin Neoplasms
  • Uveal Neoplasms

Keywords

  • GNAQ
  • Plp1
  • blue nevus
  • leptomeningeal melanocytoma
  • uveal melanoma

GNE

Aberrant mitochondrial morphology and function associated with impaired mitophagy and DNM1L-MAPK/ERK signaling are found in aged mutant Parkinsonian LRRK2 mice.


Keywords

  • Aging
  • Dnm1l/DRP1
  • SQSTM1/p62
  • knockin mice
  • macroautophagy
  • mitochondria dysfunction
  • mitochondrial fission
  • mitophagy
  • parkinson disease
  • ubiquitination

GPC1

Decreased expression of GPC1 in human skin keratinocytes and epidermis during ageing.


MeSH Terms

  • Adult
  • Aged
  • Aged, 80 and over
  • Aging
  • Cell Proliferation
  • Cells, Cultured
  • Epidermis
  • Female
  • Fibroblast Growth Factor 2
  • Gene Expression Regulation
  • Glypicans
  • Humans
  • Keratinocytes
  • Middle Aged
  • RNA, Messenger
  • Signal Transduction
  • Skin
  • Young Adult

Keywords

  • Ageing
  • Epidermis
  • Glypican 1
  • Human skin
  • Keratinocytes

GPI

Blood factors transfer beneficial effects of exercise on neurogenesis and cognition to the aged brain.


MeSH Terms

  • Aging
  • Animals
  • Blood Circulation
  • Brain
  • Cognition
  • Cognitive Dysfunction
  • Glycosylphosphatidylinositols
  • Liver
  • Mice
  • Neurogenesis
  • Phospholipase D
  • Physical Conditioning, Animal
  • Regeneration
  • Signal Transduction

GPR6

Accelerated Epigenetic Aging and Methylation Disruptions Occur in Human Immunodeficiency Virus Infection Prior to Antiretroviral Therapy.


Keywords

  • HIV
  • aging
  • epigenetics
  • methylation

GPT

Brain Structural-Behavioral Correlates Underlying Grooved Pegboard Test Performance Across Lifespan.


Keywords

  • aging
  • gray matter
  • visuomotor function
  • white matter

GPX1

Glutathione peroxidase-1 overexpression reduces oxidative stress, and improves pathology and proteome remodeling in the kidneys of old mice.


Keywords

  • glutathione peroxidase-1
  • kidney aging
  • mitochondria
  • proteomics
  • reactive oxygen species

GPX3

Long noncoding RNA glutathione peroxidase 3-antisense inhibits lens epithelial cell apoptosis by upregulating glutathione peroxidase 3 expression in age-related cataract.


MeSH Terms

  • Aging
  • Anterior Capsule of the Lens
  • Apoptosis
  • Cataract
  • Cell Line
  • Cell Nucleus
  • Epithelial Cells
  • Glutathione Peroxidase
  • Humans
  • Hydrogen Peroxide
  • Lens, Crystalline
  • RNA, Long Noncoding
  • Up-Regulation

GPX4

l-carnitine supplementation during in vitro culture regulates oxidative stress in embryos from bovine aged oocytes.


MeSH Terms

  • Animals
  • Carnitine
  • Cattle
  • Culture Media
  • Embryo Culture Techniques
  • Female
  • Fertilization in Vitro
  • In Vitro Oocyte Maturation Techniques
  • Oocytes
  • Oxidative Stress

Keywords

  • Bovine
  • Embryo development
  • Oocyte aging
  • l-carnitine


Dietary Selenium Supplementation Ameliorates Female Reproductive Efficiency in Aging Mice.


Keywords

  • GPX4
  • Gpx1
  • Gpx3
  • Selenof
  • apoptosis
  • embryo
  • follicle development
  • ovarian aging
  • selenium
  • selenoprotein

GREM1

GREM1 inhibits osteogenic differentiation, senescence and BMP transcription of adipose-derived stem cells.


Keywords

  • BMP
  • GREM1
  • adipose-derived stem cells (ADSCs)
  • osteogenic differentiation
  • senescence

GREM2

Increase of gremlin 2 with age in human adipose-derived stromal/stem cells and its inhibitory effect on adipogenesis.


Keywords

  • Adipogenic differentiation
  • Adipose-derived stromal/stem stem cells
  • Aging
  • DAPI, 4′,6-diamidino-2-phenylindole
  • FGF, fibroblast growth factor
  • GREM2
  • GREM2 knockdown
  • HE, hematoxylin eosin
  • Individual differences
  • PBS, phosphate buffered Solution
  • PFA, paraformaldehyde
  • TGF-β, transforming growth factor beta

GRID1

Gene discovery for high-density lipoprotein cholesterol level change over time in prospective family studies.


Keywords

  • GWAS
  • HDL-C metabolism
  • Healthy aging
  • Longevity
  • Longitudinal HDL-C change

GRIK2

Senescence of Normal Human Fibroblasts Relates to the Expression of Ionotropic Glutamate Receptor GluR6/Grik2.


Keywords

  • GluR6
  • Grik2
  • Senescence
  • cancer
  • glutamate receptor
  • normal fibroblasts

GRK2

G protein-coupled receptor kinase 2 modifies the ability of Caenorhabditis elegans to survive oxidative stress.


Keywords

  • Aging
  • Caenorhabditis elegans (C. elegans)
  • G protein coupled receptor kinase (GRK)
  • Oxidative stress
  • Resistance
  • Stress response


G protein coupled receptor kinases modulate Caenorhabditis elegans reactions to heat stresses.


Keywords

  • Aging
  • Biological control
  • Caenorhabditis elegans (C. elegans)
  • G protein coupled receptor (GPCR)
  • G protein coupled receptor kinase (GRK)
  • Heat stress
  • Resistance
  • Stress response


Loss of dynamic regulation of G protein-coupled receptor kinase 2 by nitric oxide leads to cardiovascular dysfunction with aging.


MeSH Terms

  • Aging
  • Animals
  • Female
  • G Protein-Coupled Inwardly-Rectifying Potassium Channels
  • Heart
  • Heart Diseases
  • Homeostasis
  • Male
  • Mice
  • Mutation
  • Myocardium
  • Nitric Oxide

Keywords

  • S-nitrosylation
  • cardiac hypertrophy
  • heart disease

GRM3

Profiling gene expression in the human dentate gyrus granule cell layer reveals insights into schizophrenia and its genetic risk.


MeSH Terms

  • Adolescent
  • Adult
  • Aged
  • Aged, 80 and over
  • Aging
  • Bipolar Disorder
  • Dentate Gyrus
  • Depressive Disorder, Major
  • Female
  • Gene Expression Profiling
  • Genetic Predisposition to Disease
  • Genome-Wide Association Study
  • Humans
  • Male
  • Middle Aged
  • Neurons
  • Quantitative Trait Loci
  • Schizophrenia
  • Transcriptome
  • Young Adult

GRN

Stressful development: Integrating endoderm development, stress, and longevity.


Keywords

  • Caenorhabditis elegans
  • Embryonic development
  • Epigenetics inheritance
  • Innate immunity
  • Longevity
  • Pleiotropy
  • Stress


A Scoping Review of the Evidence About the Nurses Improving Care for Healthsystem Elders (NICHE) Program.


Keywords

  • Aging
  • Geriatric nursing
  • Health care professionals
  • Intervention
  • Quality improvement

GSC

[i]mastermind[/i] regulates niche ageing independently of the [i]Notch[/i] pathway in the [i]Drosophila[/i] ovary.


MeSH Terms

  • Aging
  • Animals
  • Cellular Senescence
  • Drosophila Proteins
  • Drosophila melanogaster
  • Female
  • Germ Cells
  • Nuclear Proteins
  • Ovary
  • Receptors, Notch
  • Signal Transduction
  • Stem Cell Niche
  • Transcriptome

Keywords

  • DE-cadherin
  • Drosophila oogenesis
  • Hedgehog
  • mastermind
  • niche ageing
  • reactive oxygen species

GSTM1

The effects of everyday-life exposure to polycyclic aromatic hydrocarbons on biological age indicators.


Keywords

  • Biological aging
  • DNA adduct
  • Mitochondrial DNA copy number
  • Polycyclic aromatic hydrocarbon
  • Structural equation modelling
  • Telomere length

GSTM2

Small Extracellular Vesicles Have GST Activity and Ameliorate Senescence-Related Tissue Damage.


Keywords

  • 4-HNE
  • EV
  • GSH
  • GST
  • ROS
  • SASP
  • aging
  • extracellular vesicles
  • glutathione metabolism
  • glutathione-S-transferase
  • lipid peroxidation
  • rejuvenation
  • senescence
  • senescence-associated secretory phenotype

GUK1

Characterization of the impact of GMP/GDP synthesis inhibition on replicative lifespan extension in yeast.


Keywords

  • Aging
  • GDP
  • GMP
  • Mycophenolic acid
  • Proteasome
  • Replicative lifespan
  • Yeast

GZMK

Comprehensive Profiling of an Aging Immune System Reveals Clonal GZMK CD8 T Cells as Conserved Hallmark of Inflammaging.


Keywords

  • Aging
  • CD8 T cells
  • CITE-seq
  • granzyme K
  • immune system
  • inflammaging
  • single-cell ATAC-sequencing
  • single-cell BCR-sequencing
  • single-cell RNA-sequencing
  • single-cell TCR-sequencing

H2AX

Evaluation of GammaH2AX in Buccal Cells as a Molecular Biomarker of DNA Damage in Alzheimer's Disease in the AIBL Study of Ageing.


Keywords

  • Alzheimer’s disease
  • DNA damage
  • mild cognitive impairment
  • senescence
  • γH2AX


Cisplatin-induced peripheral neuropathy is associated to neuronal senescence-like response.


Keywords

  • cisplatin
  • neuropathy
  • neurotoxicity
  • p21
  • senescence


Guanine Deaminase Stimulates Ultraviolet-induced Keratinocyte Senescence in Seborrhoeic Keratosis via Guanine Metabolites.


Keywords

  • DNA damage
  • UV-induced keratinocyte senescence
  • guanine deaminase
  • reactive oxygen species
  • uric acid
  • seborrhoeic keratosis


Do BRCA1 and BRCA2 gene mutation carriers have a reduced ovarian reserve? Protocol for a prospective observational study.


MeSH Terms

  • Adolescent
  • Adult
  • Aging
  • BRCA1 Protein
  • BRCA2 Protein
  • Female
  • Germ-Line Mutation
  • Heterozygote
  • Humans
  • Immunohistochemistry
  • Middle Aged
  • Observational Studies as Topic
  • Ovarian Follicle
  • Ovarian Reserve
  • Prospective Studies
  • Research Design
  • Young Adult

Keywords

  • BRCA
  • DNA repair
  • fertility
  • follicle
  • germline mutation
  • oocyte


Slower rates of accumulation of DNA damage in leukocytes correlate with longer lifespans across several species of birds and mammals.


MeSH Terms

  • Animals
  • Birds
  • Bottle-Nosed Dolphin
  • Cross-Sectional Studies
  • DNA Damage
  • Goats
  • Leukocytes
  • Longevity
  • Reindeer
  • Turtles
  • Vertebrates

Keywords

  • DNA damage
  • lifespan
  • short telomeres
  • species


Phosphoproteomic analysis reveals plant DNA damage signalling pathways with a functional role for histone H2AX phosphorylation in plant growth under genotoxic stress.


MeSH Terms

  • ATP-Binding Cassette Transporters
  • Aging
  • Arabidopsis
  • Arabidopsis Proteins
  • Cells, Cultured
  • DNA Damage
  • DNA Repair
  • Gene Expression Regulation, Plant
  • Gene Ontology
  • Germination
  • Histones
  • Mass Spectrometry
  • Phosphorylation
  • Proteome
  • Seeds
  • Serine
  • Signal Transduction
  • Stress, Physiological
  • X-Rays

Keywords

  • ATAXIA TELANGIECTASIA MUTATED (ATM)
  • DNA damage response
  • DNA repair
  • phosphorylation
  • seed

HBM

The effects of dietary fatty acids on bone, hematopoietic marrow and marrow adipose tissue in a murine model of senile osteoporosis.


MeSH Terms

  • Adipose Tissue
  • Adiposity
  • Animals
  • Bone Density
  • Bone Marrow
  • Dietary Fats
  • Dietary Supplements
  • Disease Models, Animal
  • Fatty Acids, Omega-3
  • Female
  • Femur
  • Mice
  • Osteoporosis
  • X-Ray Microtomography

Keywords

  • SAMP8 mouse
  • aging
  • fish oil
  • marrow adipose tissue
  • osteoporosis

HBP1

Suppression of p38/HBP1 pathway alleviates hyperosmotic stress-induced senescent progression of chondrocyte senescence.


MeSH Terms

  • Cellular Senescence
  • Chondrocytes
  • Disease Progression
  • High Mobility Group Proteins
  • Humans
  • Osteoarthritis
  • Repressor Proteins
  • Up-Regulation
  • p38 Mitogen-Activated Protein Kinases

Keywords

  • HBP1
  • chondrocyte
  • osmolality stress
  • p38
  • senescence

HCN1

Protein expression changes of HCN1 and HCN2 in hippocampal subregions of gerbils during the normal aging process.


Keywords

  • Aging
  • Dentate gyrus
  • Granule cells
  • HCN channel
  • Hippocampus proper
  • Pyramidal cells

HDAC1

HDAC1 modulates OGG1-initiated oxidative DNA damage repair in the aging brain and Alzheimer's disease.


MeSH Terms

  • Acetylation
  • Aging
  • Alzheimer Disease
  • Animals
  • Astrocytes
  • Base Sequence
  • Benzophenones
  • Brain
  • Cognition
  • Cognition Disorders
  • DNA Damage
  • DNA Glycosylases
  • Down-Regulation
  • Gene Ontology
  • Guanine
  • Histone Deacetylase 1
  • Memory
  • Mice, Inbred C57BL
  • Mice, Knockout
  • Neurons
  • Oxidative Stress
  • Promoter Regions, Genetic

HDAC10

Middle-aged female rats lack changes in histone H3 acetylation in the anterior hypothalamus observed in young females on the day of a luteinizing hormone surge.


MeSH Terms

  • Acetylation
  • Age Factors
  • Animals
  • Estradiol
  • Female
  • Histones
  • Hypothalamus, Anterior
  • Luteinizing Hormone
  • Rats
  • Rats, Sprague-Dawley

Keywords

  • Histone acetylation
  • LH
  • aging
  • histone deacetylases
  • hypothalamus

HDAC2

EEF1A1 deacetylation enables transcriptional activation of remyelination.


MeSH Terms

  • Acetylation
  • Aging
  • Animals
  • Cell Dedifferentiation
  • Cell Nucleus
  • Histone Deacetylase 1
  • Histone Deacetylase 2
  • Lysine Acetyltransferase 5
  • Mice
  • Models, Biological
  • Oligodendroglia
  • Peptide Elongation Factor 1
  • Peripheral Nervous System
  • Recovery of Function
  • Remyelination
  • SOXE Transcription Factors
  • STAT3 Transcription Factor
  • Schwann Cells
  • Theophylline
  • Trans-Activators
  • Transcriptional Activation

HDAC3

Histone deacetylase-3: Friend and foe of the brain.


Keywords

  • Histone deacetylases
  • aging
  • histone deacetylase-3
  • learning and memory
  • neurodegenerative diseases
  • neurodevelopment


Loss of HDAC3 contributes to meiotic defects in aged oocytes.


MeSH Terms

  • Animals
  • Cells, Cultured
  • Cellular Senescence
  • Female
  • Histone Deacetylases
  • Meiosis
  • Mice
  • Mice, Inbred ICR
  • Oocytes

Keywords

  • HDACs
  • aneuploidy
  • maternal aging
  • oocyte quality
  • reproduction

HDAC4

The posttranslational modification of HDAC4 in cell biology: Mechanisms and potential targets.


Keywords

  • HDAC4
  • cell senescence
  • cellular apoptosis and autophagy
  • glucose metabolism
  • inflammation and pathology
  • proliferation and differentiation

HDAC6

Inhibition of HDAC6 Attenuates Diabetes-Induced Retinal Redox Imbalance and Microangiopathy.


Keywords

  • HDAC6
  • diabetic retinopathy
  • oxidative stress
  • retinal endothelial cell senescence
  • retinal endothelial cells
  • tubastatin A

HDC

Induced pluripotency and spontaneous reversal of cellular aging in supercentenarian donor cells.


MeSH Terms

  • Adult
  • Aged, 80 and over
  • Cell Differentiation
  • Cell Line
  • Cellular Reprogramming
  • Cellular Senescence
  • Child
  • Clone Cells
  • Gene Expression Regulation
  • Humans
  • Induced Pluripotent Stem Cells
  • Mesenchymal Stem Cells
  • Telomere Homeostasis
  • Tissue Donors
  • Transcriptome

Keywords

  • Aging
  • Longevity
  • Reprogramming
  • Supercentenarian
  • Telomere
  • iPSC

HES1

A Single-Cell Transcriptomic Atlas of Human Skin Aging.


Keywords

  • HES1
  • KLF6
  • aging
  • fibroblast
  • keratinocyte
  • quercetin
  • senescence
  • single-cell RNA sequencing
  • skin

HFE

Polyphenol Characterization and Skin-Preserving Properties of Hydroalcoholic Flower Extract from [i]Himantoglossum robertianum[/i] (Orchidaceae).


Keywords

  • Himantoglossum robertianum
  • antioxidants
  • collagenase
  • elastase
  • flavonoids
  • keratinocytes
  • skin aging

HGD

High-glucose diets induce mitochondrial dysfunction in Caenorhabditis elegans.


MeSH Terms

  • Animals
  • Caenorhabditis elegans
  • Diet
  • Gene Expression Regulation
  • Glucose
  • Longevity
  • Mitochondria
  • Mitophagy

HGF

Age-related changes in the immunomodulatory effects of human dental pulp derived mesenchymal stem cells on the CD4 T cell subsets.


Keywords

  • Aging
  • CD4 T cell
  • Dental pulp
  • Immunomodulation
  • Mesenchymal stem cell


Hepatocyte growth factor (HGF) and stem cell factor (SCF) maintained the stemness of human bone marrow mesenchymal stem cells (hBMSCs) during long-term expansion by preserving mitochondrial function via the PI3K/AKT, ERK1/2, and STAT3 signaling pathways.


Keywords

  • Hepatocyte growth factor
  • Mitochondrial function
  • Osteogenic differentiation
  • Senescence
  • Stem cell factor
  • Stem cells from human exfoliated deciduous teeth
  • Stemness


Phenytoin sodium-ameliorated gingival fibroblast aging is associated with autophagy.


Keywords

  • aging
  • autophagy
  • gingival fibroblast
  • phenytoin sodium


Impaired integrin α /β -mediated hepatocyte growth factor release by stellate cells of the aged liver.


Keywords

  • aging
  • hepatic stellate cells
  • integrins
  • laminins
  • mechanobiology

HGS

Handgrip strength asymmetry is associated with future falls in older Americans.


Keywords

  • Aging
  • Functional laterality
  • Geriatric assessment
  • Geriatrics
  • Muscle strength dynamometer


Examining Additional Aspects of Muscle Function with a Digital Handgrip Dynamometer and Accelerometer in Older Adults: A Pilot Study.


Keywords

  • aging
  • geriatric assessment
  • muscle strength
  • muscle weakness
  • physical functional performance


The Relationship between Muscular Strength and Depression in Older Adults with Chronic Disease Comorbidity.


Keywords

  • aging
  • depression
  • disease comorbidities
  • muscular strength


Handgrip Strength in the Korean Population: Normative Data and Cutoff Values.


Keywords

  • Aging
  • Hand strength
  • Muscle strength
  • Nutrition surveys
  • Sarcopenia


Handgrip Strength Asymmetry and Weakness Are Associated with Lower Cognitive Function: A Panel Study.


Keywords

  • aging
  • functional laterality
  • geriatric assessment
  • geriatrics
  • muscle strength dynamometer


Handgrip Strength Asymmetry and Weakness are Differentially Associated with Functional Limitations in Older Americans.


MeSH Terms

  • Aged
  • Aged, 80 and over
  • Female
  • Geriatric Assessment
  • Hand Strength
  • Humans
  • Male
  • Middle Aged
  • Muscle Strength
  • Muscle Strength Dynamometer
  • Muscle Weakness
  • Odds Ratio
  • United States

Keywords

  • aging
  • geriatrics
  • muscle strength
  • muscle strength dynamometer
  • nutrition surveys


Absolute and Body Mass Index Normalized Handgrip Strength Percentiles by Gender, Ethnicity, and Hand Dominance in Americans.


Keywords

  • aging
  • epidemiology
  • hand strength
  • human development
  • muscle weakness


Hand grip strength variability during serial testing as an entropic biomarker of aging: a Poincaré plot analysis.


MeSH Terms

  • Aged
  • Aged, 80 and over
  • Aging
  • Biomarkers
  • Cross-Sectional Studies
  • Entropy
  • Female
  • Hand Strength
  • Heart Rate
  • Humans
  • Male

Keywords

  • Aging
  • Entropy
  • Hand grip strength
  • Nonlinear dynamics
  • Poincaré plot
  • Time series


Physical Activity and Fitness in White- and Blue-Collar Retired Men.


MeSH Terms

  • Aged
  • Aged, 80 and over
  • Aging
  • Body Mass Index
  • Exercise
  • Geriatric Assessment
  • Humans
  • Longitudinal Studies
  • Male
  • Men's Health
  • Occupations
  • Physical Fitness
  • Poland
  • Retirement
  • Social Class
  • Surveys and Questionnaires
  • Task Performance and Analysis

Keywords

  • Retirement
  • occupation
  • old men
  • physical activity


Association between Hand Grip Strength and Self-Rated Health in Middle- and Old-Aged Korean Citizens.


Keywords

  • Hand Grip Strength
  • Korean Longitudinal Study of Aging
  • Self-Rated Health


Weakness May Have a Causal Association With Early Mortality in Older Americans: A Matched Cohort Analysis.


Keywords

  • Aging
  • Epidemiology
  • Geriatrics
  • hand strength
  • muscle strength
  • sarcopenia


Associations Between Dietary Patterns and Handgrip Strength: The Korea National Health and Nutrition Examination Survey 2014-2016.


Keywords

  • Dietary patterns
  • Korea National Health and Nutrition Examination Survey
  • aging
  • diet
  • handgrip strength


Effect of relative handgrip strength on cardiovascular disease among Korean adults aged 45 years and older: Results from the Korean Longitudinal Study of Aging (2006-2016).


MeSH Terms

  • Adult
  • Aged
  • Aged, 80 and over
  • Aging
  • Cardiovascular Diseases
  • Female
  • Hand Strength
  • Humans
  • Longitudinal Studies
  • Male
  • Middle Aged
  • Muscle Strength
  • Muscle, Skeletal
  • Republic of Korea
  • Risk Factors

Keywords

  • Cardiovascular disease
  • KLoSA
  • Relative handgrip strength


Weakness and cognitive impairment are independently and jointly associated with functional decline in aging Americans.


MeSH Terms

  • Activities of Daily Living
  • Aged
  • Aging
  • Cognitive Dysfunction
  • Geriatric Assessment
  • Hand Strength
  • Humans
  • Middle Aged

Keywords

  • Dementia
  • Epidemiology
  • Geriatrics
  • Muscle strength
  • Nervous system


Association of phase angle with sarcopenia and its components in physically active older women.


MeSH Terms

  • Aged
  • Cross-Sectional Studies
  • Electric Impedance
  • Female
  • Hand Strength
  • Humans
  • Muscle Strength
  • Sarcopenia
  • Walking Speed

Keywords

  • Aging
  • Bioimpedance
  • Muscle function
  • Muscle mass

HLA-DRB1

The pathophysiology of polymyalgia rheumatica, small pieces of a big puzzle.


Keywords

  • Aging
  • B cell
  • HLA-DR
  • Interleukin-6
  • Polymyalgia rheumatica
  • T cell

HMGA1

Characterization of [i]HMGA1P6[/i] transgenic mouse embryonic fibroblasts.


Keywords

  • CeRNA
  • HMGA1
  • HMGA1P6
  • pseudogenes
  • senescence

HMGA2

4D Genome Rewiring during Oncogene-Induced and Replicative Senescence.


MeSH Terms

  • Cells, Cultured
  • Cellular Senescence
  • Chromatin Assembly and Disassembly
  • DNA (Cytosine-5-)-Methyltransferase 1
  • DNA Methylation
  • Fibroblasts
  • Genome, Human
  • Heterochromatin
  • Humans
  • In Situ Hybridization, Fluorescence
  • Oncogenes

Keywords

  • 3D genome architecture
  • DNMT1
  • Hi-C
  • chromatin compartments
  • gene regulation
  • oncogene-induced senescence
  • replicative senescence
  • senescence


The protective effects of HMGA2 in the senescence process of bone marrow-derived mesenchymal stromal cells.


Keywords

  • bone marrow derived mesenchymal stromal cells (MSCs)
  • high-mobility group AT-hook 2 (HMGA2)
  • regulator of G protein signaling 2 (Rgs2)
  • senescence

HMGB1

Senescent human melanocytes drive skin ageing via paracrine telomere dysfunction.


MeSH Terms

  • Adult
  • Aged
  • Aged, 80 and over
  • Aging
  • Atrophy
  • Cells, Cultured
  • Cellular Senescence
  • Cyclin-Dependent Kinase Inhibitor p16
  • Epidermis
  • Female
  • Humans
  • Male
  • Melanocytes
  • Middle Aged
  • Paracrine Communication
  • Reactive Oxygen Species
  • Receptors, CXCR4
  • Skin
  • Telomere
  • Young Adult

Keywords

SASP

  • melanocytes
  • senescence
  • skin ageing
  • telomeres

HMGCR

Cholesterol Homeostasis: An In Silico Investigation into How Aging Disrupts Its Key Hepatic Regulatory Mechanisms.


Keywords

  • aging
  • cholesterol biosynthesis
  • mathematical model
  • reactive oxygen species
  • systems biology


Artesunate inhibits the mevalonate pathway and promotes glioma cell senescence.


Keywords

  • artesunate
  • distant seeding
  • glioma
  • mevalonate pathway
  • senescence

HOXD8

Single-Cell Transcriptome Analysis Reveals Six Subpopulations Reflecting Distinct Cellular Fates in Senescent Mouse Embryonic Fibroblasts.


Keywords

  • Hoxd8
  • cellular senescence
  • mouse embryonic fibroblasts
  • senescence-associated secretory phenotype
  • single-cell RNA sequencing
  • transcriptomic heterogeneity

HP

A narrative review of highly processed food addiction across the lifespan.


Keywords

  • Adolescence
  • Adulthood
  • Childhood
  • Food addiction
  • Infancy
  • Lifespan
  • Prenatal


Beta Human Papillomavirus 8E6 Attenuates LATS Phosphorylation after Failed Cytokinesis.


MeSH Terms

  • Apoptosis
  • Cell Cycle Proteins
  • Cell Line, Tumor
  • Cell Proliferation
  • Cell Survival
  • Cytochalasin B
  • Cytokinesis
  • DNA Repair
  • E1A-Associated p300 Protein
  • Gene Expression Regulation
  • HCT116 Cells
  • Host-Pathogen Interactions
  • Humans
  • Keratinocytes
  • Oncogene Proteins, Viral
  • Osteoblasts
  • Papillomaviridae
  • Phenotype
  • Phosphorylation
  • Primary Cell Culture
  • Protein-Serine-Threonine Kinases
  • Signal Transduction
  • Transcription Factors
  • Tumor Suppressor Protein p53

Keywords

  • Hippo signaling pathway
  • apoptosis
  • cancer
  • cytokinesis
  • human papillomavirus
  • senescence
  • skin cancer

HPSE

Distribution of heparan sulfate correlated with the expression of heparanase-1 and matrix metalloproteinase-9 in an ovariectomized rats skin.


Keywords

  • aging
  • estrogen
  • extracellular matrix
  • heparan sulfate
  • heparanase-1
  • matrix metalloproteinase-9

HR

Patients with hip fracture and total hip arthroplasty surgery differ in anthropometric, but not cardiovascular screening abnormalities.


Keywords

  • Aging
  • Cardiovascular reactivity
  • Heart rate variability
  • Hip fracture
  • Total hip arthroplasty


Clinical Role of Lung Ultrasound for the Diagnosis and Prognosis of Coronavirus Disease Pneumonia in Elderly Patients: A Pivotal Study.


Keywords

  • Aging
  • Coronavirus disease
  • Elderly
  • Lung ultrasound
  • Severe acute respiratory syndrome-coronavirus-2


The Relationship of Accelerometer-Assessed Standing Time With and Without Ambulation and Mortality: The WHI OPACH Study.


Keywords

  • Accelerometer
  • Longevity
  • Physical activity


Age-related myofiber atrophy in old mice is reversed by ten weeks voluntary high-resistance wheel running.


Keywords

  • Aging
  • Exercise
  • Mouse model
  • Muscle morphology
  • Skeletal muscle
  • Training


Predicted Skeletal Muscle Mass and 4-Year Cardiovascular Disease Incidence in Middle-Aged and Elderly Participants of IKARIA Prospective Epidemiological Study: The Mediating Effect of Sex and Cardiometabolic Factors.


Keywords

  • aging
  • body composition
  • gender
  • heart disease
  • lean mass
  • obesity
  • primary prevention
  • women


Obesity is associated with early hip fracture risk in postmenopausal women: a 25-year follow-up.


Keywords

  • Aging
  • Body mass index
  • Bone mineral density
  • Follow-up study
  • General population
  • Hip fracture
  • Menopause
  • Obesity


ATM inhibition synergizes with fenofibrate in high grade serous ovarian cancer cells.


Keywords

  • Biochemistry
  • Bioinformatics
  • Cancer research
  • Cell biology
  • Cellular metabolism
  • Cellular senescence
  • Drug combinations
  • Homologous recombination
  • Metabolite
  • Molecular biology
  • PPARa


Effectiveness of adjuvant FOLFOX vs 5FU/LV in adults over age 65 with stage II and III colon cancer using a novel hybrid approach.


Keywords

  • aging
  • cancer
  • chemotherapy
  • comparative effectiveness research
  • pharmacoepidemiology


Age, Frailty, and Comorbidity as Prognostic Factors for Short-Term Outcomes in Patients With Coronavirus Disease 2019 in Geriatric Care.


MeSH Terms

  • Age Factors
  • Aged
  • Aged, 80 and over
  • Betacoronavirus
  • COVID-19
  • Comorbidity
  • Coronavirus Infections
  • Female
  • Frail Elderly
  • Geriatrics
  • Humans
  • Male
  • Models, Statistical
  • Outcome Assessment, Health Care
  • Pandemics
  • Pneumonia, Viral
  • Prognosis
  • SARS-CoV-2
  • Survival Analysis
  • Sweden

Keywords

  • COVID-19
  • aging
  • comorbidity
  • frailty
  • geriatrics
  • survival


Clinical and demographic parameters predict the progression from mild cognitive impairment to dementia in elderly patients.


Keywords

  • Aging
  • Cox regression
  • Dementia
  • Follow-up
  • Mild cognitive impairment


Plasma Dehydroepiandrosterone Sulfate and Cardiovascular Disease Risk in Older Men and Women.


Keywords

  • DHEA-S
  • aging
  • heart failure
  • mortality


High intensity interval training combined with L-citrulline supplementation: Effects on physical performance in healthy older adults.


Keywords

  • Aging
  • Body composition
  • Exercise
  • Mobility
  • Nutrition


Associations of blood pressure with risk of injurious falls in old age vary by functional status: A cohort study.


Keywords

  • Aging
  • Blood pressure
  • Falls
  • Injury
  • Swedish National study on Aging and Care in Kungsholmen (SNAC-K)


Epigenetic age acceleration and clinical outcomes in gliomas.


MeSH Terms

  • Adult
  • Aging
  • DNA Methylation
  • Epigenesis, Genetic
  • Female
  • Glioma
  • Humans
  • Male
  • Middle Aged
  • Prognosis
  • Survival Analysis


Do Stairs Inhibit Seniors Who Live on Upper Floors From Going Out?


Keywords

  • active aging
  • activity monitor
  • homebound
  • mobility
  • walk-up buildings


Age-specific acute changes in carotid-femoral pulse wave velocity with head-up tilt.


Keywords

  • arterial function
  • arterial stiffness
  • blood pressure
  • early vascular aging
  • pressure dependence


Pre-frailty status increases the risk of rehospitalization in patients after elective cardiac surgery without complication.


MeSH Terms

  • Aged
  • Cardiac Surgical Procedures
  • Elective Surgical Procedures
  • Female
  • Frailty
  • Humans
  • Male
  • Patient Readmission
  • Postoperative Complications
  • Retrospective Studies
  • Risk

Keywords

  • adverse events
  • aging
  • cardiac surgery
  • frailty
  • rehospitalization


Comparative Performance of Creatinine-Based GFR Estimation Equations in Exceptional Longevity: The Rugao Longevity and Ageing Study.


MeSH Terms

  • Aged, 80 and over
  • Creatinine
  • Female
  • Glomerular Filtration Rate
  • Humans
  • Kidney Function Tests
  • Longevity
  • Male
  • Mortality
  • Predictive Value of Tests
  • Renal Insufficiency
  • Reproducibility of Results
  • Risk Factors

Keywords

  • equation
  • exceptional longevity
  • glomerular filtration rate
  • kidney function
  • mortality


Sex-and race-specific associations of protein intake with change in muscle mass and physical function in older adults: the Health, Aging, and Body Composition (Health ABC) Study.


MeSH Terms

  • Aged
  • Aged, 80 and over
  • Aging
  • Biomass
  • Body Composition
  • Body Weight
  • Dietary Proteins
  • Female
  • Humans
  • Independent Living
  • Male
  • Muscle Development
  • Muscle Strength
  • Muscles
  • Prospective Studies
  • Sex Factors

Keywords

  • appendicular lean body mass
  • community-dwelling
  • gait speed
  • mobility limitation
  • old age
  • optimal intake
  • physical performance
  • spline functions


Deterioration of bone microstructure by aging and menopause in Japanese healthy women: analysis by HR-pQCT.


MeSH Terms

  • Absorptiometry, Photon
  • Adult
  • Aged
  • Aging
  • Asian Continental Ancestry Group
  • Bone Density
  • Bone and Bones
  • Cancellous Bone
  • Cortical Bone
  • Female
  • Finite Element Analysis
  • Humans
  • Japan
  • Linear Models
  • Menopause
  • Middle Aged
  • Porosity
  • Tomography, X-Ray Computed

Keywords

  • Bone microstructure
  • Estimated bone strength
  • High resolution peripheral quantitative CT (HR-pQCT)
  • Japanese women
  • Non-metric trabecular parameter


Association between Low Protein Intake and Mortality in Patients with Type 2 Diabetes.


Keywords

  • aging
  • diabetes
  • mortality
  • nutritional support
  • protein intake


CAUSES, mortality rates and risk factors of death in community-dwelling Europeans aged 50 years and over: Results from the Survey of Health, Ageing and Retirement in Europe 2013-2015.


MeSH Terms

  • Activities of Daily Living
  • Aged
  • Aging
  • Cohort Studies
  • Europe
  • Humans
  • Independent Living
  • Male
  • Middle Aged
  • Mortality
  • Proportional Hazards Models
  • Prospective Studies
  • Retirement
  • Risk Factors
  • Surveys and Questionnaires

Keywords

  • Aging
  • Comorbidity
  • Depressive symptoms
  • Diseases
  • Mortality risk


Estimation of Wave Condition Number From Pressure Waveform Alone and Its Changes With Advancing Age in Healthy Women and Men.


Keywords

  • arterial wave reflection
  • cardiovascular biomarker
  • optimum cardiovascular function
  • vascular aging
  • wave condition number


Extended in vitro culture of primary human mesenchymal stem cells downregulates Brca1-related genes and impairs DNA double-strand break recognition.


Keywords

BRCA1

  • DNA repair
  • cellular aging
  • homologous recombination
  • mesenchymal stem cells


Effect of artificial dawn light on cardiovascular function, alertness, and balance in middle-aged and older adults.


Keywords

  • aging
  • alertness
  • balance
  • blood pressure
  • heart rate
  • heart rate variability
  • light
  • sleep inertia


Heart Rate Performance Curve Is Dependent on Age, Sex, and Performance.


Keywords

  • aging
  • heart rate deflection
  • intensity prescription
  • maximal heart rate
  • sex differences
  • ß1-receptor sensitivity


Physical activity trajectories, mortality, hospitalization, and disability in the Toledo Study of Healthy Aging.


Keywords

  • Adverse outcomes
  • Healthy aging
  • Mortality
  • Older adults
  • Physical activity
  • Trajectories


U-Shaped Association of Plasma Testosterone, and no Association of Plasma Estradiol, with Incidence of Fractures in Men.


Keywords

  • estradiol
  • fracture
  • male aging
  • osteoporosis
  • sex hormone-binding globulin
  • testosterone


Pregnancy-Related Bone Mineral and Microarchitecture Changes in Women Aged 30 to 45 Years.


Keywords

  • AGING
  • ANALYSIS/QUANTITATION OF BONE
  • BONE QCT/μCT
  • EPIDEMIOLOGY
  • GENERAL POPULATION STUDIES


Analysis of the world record time for combined father and son marathon.


Keywords

  • V̇o2max
  • aerobic exercise
  • aging
  • endurance
  • oxygen consumption
  • running


Age-related reductions in heart rate variability do not worsen during exposure to humid compared to dry heat: A secondary analysis.


Keywords

  • Aging
  • autonomic nervous system
  • heat stress
  • parasympathetic nervous system
  • relative humidity
  • sympathetic nervous system


Efficacy and Safety of Dapagliflozin in the Elderly: Analysis From the DECLARE-TIMI 58 Study.


MeSH Terms

  • Adult
  • Age Factors
  • Aged
  • Aged, 80 and over
  • Aging
  • Benzhydryl Compounds
  • Cardiovascular System
  • Diabetes Mellitus, Type 2
  • Diabetic Ketoacidosis
  • Female
  • Glucosides
  • Humans
  • Hypoglycemia
  • Hypoglycemic Agents
  • Incidence
  • Kidney
  • Male
  • Middle Aged
  • Sodium-Glucose Transporter 2 Inhibitors
  • Survival Analysis
  • Treatment Outcome
  • Urinary Tract Infections


Validity of Prediction Equations of Maximal Heart Rate in Physically Active Female Adolescents and the Role of Maturation.


MeSH Terms

  • Adolescent
  • Aging
  • Body Mass Index
  • Exercise
  • Exercise Test
  • Female
  • Heart Rate
  • Humans

Keywords

  • cardiac rate
  • exercise prescription
  • exercise testing
  • prediction equations
  • training zones
  • volleyball


Base excision repair but not DNA double-strand break repair is impaired in aged human adipose-derived stem cells.


MeSH Terms

  • Adipose Tissue
  • Adult
  • Aging
  • DNA Breaks, Double-Stranded
  • DNA End-Joining Repair
  • DNA Repair
  • Humans
  • Middle Aged
  • Recombinational DNA Repair
  • Stem Cells
  • Up-Regulation
  • X-ray Repair Cross Complementing Protein 1
  • Young Adult

Keywords

  • XRCC1
  • adipose-derived stem cells
  • base excision repair
  • genome integrity
  • human aging


Urban-Rural Differences in Hip Fracture Mortality: A Nationwide NOREPOS Study.


Keywords

  • AGING
  • EPIDEMIOLOGY
  • GENERAL POPULATION STUDIES
  • OSTEOPOROSIS
  • STATISTICAL METHODS


Malnutrition as a Strong Predictor of the Onset of Sarcopenia.


MeSH Terms

  • Aged
  • Aging
  • Cohort Studies
  • Female
  • Humans
  • Independent Living
  • Male
  • Malnutrition
  • Proportional Hazards Models
  • Prospective Studies
  • Risk Factors
  • Sarcopenia

Keywords

  • EWGSOP2
  • GLIM
  • SarcoPhAge
  • malnutrition
  • sarcopenia


Acclimation to a thermoneutral environment abolishes age-associated alterations in heart rate and heart rate variability in conscious, unrestrained mice.


Keywords

  • Aging
  • Cardiac autonomic modulation
  • Heart rate
  • Heart rate variability
  • Thermoneutrality


Long-term dementia risk prediction by the LIBRA score: A 30-year follow-up of the CAIDE study.


MeSH Terms

  • Aged
  • Apolipoproteins E
  • Cognitive Dysfunction
  • Dementia
  • Female
  • Follow-Up Studies
  • Genetic Predisposition to Disease
  • Humans
  • Life Style
  • Male
  • Protective Factors
  • Risk Assessment
  • Risk Factors

Keywords

  • cognitive aging
  • cohort study
  • dementia
  • epidemiology
  • lifestyle
  • prevention
  • risk factors


Kidney function and its association to imminent, short- and long-term fracture risk-a longitudinal study in older women.


Keywords

  • Aging
  • Bone mineral density
  • Chronic kidney disease
  • Estimated glomerular filtration rate
  • Fracture
  • Women


Oxidatively Damaged DNA/RNA and 8-Isoprostane Levels Are Associated With the Development of Type 2 Diabetes at Older Age: Results From a Large Cohort Study.


MeSH Terms

  • Age of Onset
  • Aged
  • Aging
  • Biomarkers
  • Cohort Studies
  • DNA
  • DNA Damage
  • Diabetes Mellitus, Type 2
  • Dinoprost
  • Female
  • Follow-Up Studies
  • Germany
  • Humans
  • Incidence
  • Lipid Peroxidation
  • Male
  • Middle Aged
  • Oxidation-Reduction
  • Oxidative Stress
  • RNA


Associations of vigorous physical activity with all-cause, cardiovascular and cancer mortality among 64 913 adults.


Keywords

  • cardio-protection
  • exercise
  • longevity
  • non-communicable diseases
  • physical activity


Reduced cerebrovascular and cardioventilatory responses to intermittent hypoxia in elderly.


MeSH Terms

  • Adult
  • Aged
  • Aging
  • Blood Pressure
  • Brain
  • Cerebrovascular Circulation
  • Female
  • Heart Rate
  • Humans
  • Hypoxia
  • Male
  • Pulmonary Ventilation
  • Ultrasonography, Doppler, Transcranial
  • Young Adult

Keywords

  • Aging
  • Arterial oxygen saturation
  • Cerebral blood flow
  • Cerebral tissue oxygenation
  • Heart rate
  • Hypoxemia
  • Ventilation


Vestibulo-sympathetic reflex in patients with bilateral vestibular loss.


MeSH Terms

  • Aging
  • Bilateral Vestibulopathy
  • Female
  • Humans
  • Male
  • Middle Aged
  • Reflex, Abnormal
  • Sympathetic Nervous System

Keywords

  • bilateral vestibular loss
  • compensation
  • multisensory integration
  • otolithic system
  • vestibulo-sympathetic reflex


Heart rate and blood pressure in male Ts65Dn mice: a model to investigate cardiovascular responses in Down syndrome.


MeSH Terms

  • Animals
  • Autonomic Nervous System
  • Blood Pressure
  • Circadian Rhythm
  • Down Syndrome
  • Heart Rate
  • Male
  • Mice
  • Mice, Inbred C57BL
  • Vascular Stiffness

Keywords

  • Aging
  • arterial stiffness
  • autonomic nervous system
  • circadian
  • pulse wave velocity
  • spectral analysis


Body weight at 10 years of age and change in body composition between 8 and 10 years of age were related to survival in a longitudinal study of 39 Labrador retriever dogs.


MeSH Terms

  • Adipose Tissue
  • Animals
  • Body Composition
  • Body Weight
  • Dogs
  • Longevity
  • Longitudinal Studies
  • Survival Analysis

Keywords

  • Cohort
  • Cox
  • DEXA
  • Dogs
  • Fat mass
  • Healthspan
  • Lean mass
  • Lean to fat ratio
  • Longevity
  • Sarcopenia


Dietary diversity offsets the adverse mortality risk among older indigenous Taiwanese.


MeSH Terms

  • Aged
  • Aged, 80 and over
  • Asian Continental Ancestry Group
  • Diet
  • Female
  • Health Surveys
  • Humans
  • Indigenous Peoples
  • Longevity
  • Male
  • Mortality
  • Nutrition Surveys
  • Nutritional Status
  • Risk Factors
  • Taiwan


Independent and joint effects of vascular and cardiometabolic risk factor pairs for risk of all-cause dementia: a prospective population-based study.


MeSH Terms

  • Aged
  • Aged, 80 and over
  • Aging
  • Apolipoprotein E4
  • Cognitive Dysfunction
  • Dementia
  • Exercise
  • Female
  • Heart Failure
  • Heterozygote
  • Humans
  • Hypertension
  • Male
  • Pennsylvania
  • Proportional Hazards Models
  • Prospective Studies
  • Risk Factors
  • Stroke

Keywords

  • Alzheimer‘s disease (AD)
  • apolipoprotein E (APOE)
  • cerebral vascular disease (CVD)
  • dementia
  • epidemiology


Work Ability and Job Survival: Four-Year Follow-Up.


MeSH Terms

  • Adult
  • Brazil
  • Employment
  • Female
  • Follow-Up Studies
  • Hospitals
  • Humans
  • Male
  • Proportional Hazards Models
  • Work Capacity Evaluation

Keywords

  • aging
  • healthcare worker
  • life course
  • longitudinal studies
  • prolonged work career
  • work ability


Predictivity of bioimpedance phase angle for incident disability in older adults.


Keywords

  • Aging
  • Body composition
  • Cellular health
  • Muscle mass
  • Nutrition

HRAS

How do combinations of unhealthy behaviors relate to attitudinal factors and subjective health among the adult population in the Netherlands?


MeSH Terms

  • Adult
  • Alcohol Drinking
  • Attitude to Health
  • Cluster Analysis
  • Diagnostic Self Evaluation
  • Diet, Healthy
  • Exercise
  • Female
  • Health Risk Behaviors
  • Humans
  • Life Expectancy
  • Life Style
  • Logistic Models
  • Male
  • Middle Aged
  • Netherlands
  • Prevalence
  • Sedentary Behavior
  • Smoking
  • Surveys and Questionnaires
  • Young Adult

Keywords

  • Clustering risk attitude
  • Health behaviours
  • Subjective health
  • Time orientation


Elucidating Proteoform Dynamics Underlying the Senescence Associated Secretory Phenotype.


Keywords

  • proteoform
  • quantitative proteomics
  • secretome
  • senescence
  • top-down proteomics

HS2ST1

Whole Genome Analysis of the Red-Crowned Crane Provides Insight into Avian Longevity.


MeSH Terms

  • Animals
  • Avian Proteins
  • Birds
  • Endangered Species
  • Immunity
  • Longevity
  • Polymorphism, Genetic
  • Species Specificity
  • Transcriptome
  • Whole Genome Sequencing

Keywords

  • genome
  • longevity
  • red-crowned crane

HSF1

A Mitochondrial Stress-Specific Form of HSF1 Protects against Age-Related Proteostasis Collapse.


Keywords

  • HSF1
  • PP2A
  • aging
  • mitochondria
  • molecular chaperones
  • protein aggregation
  • proteostasis
  • stress responses


Heat shock factor 1-mediated transcription activation of Omi/HtrA2 induces myocardial mitochondrial apoptosis in the aging heart.


MeSH Terms

  • Aging
  • Animals
  • Apoptosis
  • Heat Shock Transcription Factors
  • High-Temperature Requirement A Serine Peptidase 2
  • Male
  • Mice
  • Mice, Inbred C57BL
  • Mitochondria, Heart
  • Myocytes, Cardiac
  • NIH 3T3 Cells
  • Transcriptional Activation
  • Up-Regulation

Keywords

  • Omi/HtrA2
  • age-related pathology
  • cardiovascular
  • mitochondria
  • transcriptional regulation


Multifactorial Attenuation of the Murine Heat Shock Response With Age.


Keywords

  • Aging
  • HSF1
  • Stress

HSPA1A

Vitamin D3 treatment regulates apoptosis, antioxidant defense system, and DNA integrity in the epididymal sperm of an aged rat model.


MeSH Terms

  • Aging
  • Animals
  • Antioxidants
  • Apoptosis
  • Cholecalciferol
  • Epididymis
  • Male
  • Rats
  • Rats, Wistar
  • Spermatozoa

Keywords

  • aging
  • apoptosis
  • oxidative stress
  • sperm

HSPA1L

Melatonin suppresses senescence-derived mitochondrial dysfunction in mesenchymal stem cells via the HSPA1L-mitophagy pathway.


Keywords

  • HSPA1L
  • melatonin
  • mesenchymal stem cells
  • mitochondria
  • mitophagy
  • replicative senescence

HTT

Biological Aging and the Cellular Pathogenesis of Huntington's Disease.


Keywords

  • Biological aging
  • DNA damage
  • Huntington’s disease
  • cellular aging
  • microsatellite instability
  • neurodegeneration
  • oxidative stress
  • proteostasis
  • telomere

ICE1

ATBS1-INTERACTING FACTOR 2 negatively regulates dark- and brassinosteroid-induced leaf senescence through interactions with INDUCER OF CBF EXPRESSION 1.


Keywords

  • ATBS1-INTERACTING FACTOR 2 (AIF2)
  • Arabidopsis
  • C-REPEAT BINDING FACTOR (CBF)
  • INDUCER OF CBF EXPRESSION 1 (ICE1)
  • PHYTOCHROME-INTERACTING FACTORS (PIFs)
  • basic helix–loop–helix (bHLH)
  • brassinosteroid (BR)
  • leaf senescence

IDE

Dendrobium nobile Lindl. Alkaloids Ameliorate Cognitive Dysfunction in Senescence Accelerated SAMP8 Mice by Decreasing Amyloid-β Aggregation and Enhancing Autophagy Activity.


Keywords

  • Aging
  • Dendrobium nobile Lindl. alkaloid (DNLA)
  • amyloid-β
  • autophagy
  • metformin
  • senescence accelerated mouse prone 8 (SAMP8)

IDH2

Reactive oxygen species-mediated senescence is accelerated by inhibiting Cdk2 in Idh2-deficient conditions.


MeSH Terms

  • Animals
  • Cellular Senescence
  • Cyclin-Dependent Kinase 2
  • Cyclin-Dependent Kinase Inhibitor p21
  • Embryo, Mammalian
  • Fibroblasts
  • Isocitrate Dehydrogenase
  • Mice
  • Mice, Knockout
  • NIH 3T3 Cells
  • Reactive Oxygen Species

Keywords

  • cell cycle
  • cyclin-dependent kinase 2 (Cdk2)
  • isocitrate dehydrogenase 2 (IDH2)
  • reactive oxygen species (ROS)
  • senescence

IDS

Effect of immediate dentine sealing on the aging and fracture strength of lithium disilicate inlays and overlays.


Keywords

  • Aging
  • Ceramic
  • Fracture strength
  • Immediate dentin sealing
  • Inlay
  • Overlay

IFI27

Ultraviolet B irradiation-induced keratinocyte senescence and impaired development of 3D epidermal reconstruct.


Keywords

  • epidermis
  • keratinocytes
  • reactive oxygen species
  • senescence
  • skin aging
  • ultraviolet radiation

IGF1

Genetic differences and longevity-related phenotypes influence lifespan and lifespan variation in a sex-specific manner in mice.


Keywords

  • IGF1
  • antagonistic gene
  • female sexual maturation
  • lifespan variation
  • maximum lifespan
  • sex difference in lifespan


17α-estradiol modulates IGF1 and hepatic gene expression in a sex-specific manner.


Keywords

  • 17α-estradiol
  • aging
  • growth hormone
  • insulin
  • insulin-like growth factor-1
  • liver


Pan-mammalian analysis of molecular constraints underlying extended lifespan.


Keywords

  • RERconverge
  • computational biology
  • evolution
  • genetics
  • genomics
  • longevity
  • mammals
  • phylogenomics
  • systems biology


17α-Estradiol promotes ovarian aging in growth hormone receptor knockout mice, but not wild-type littermates.


Keywords

  • Follicles
  • Ovarian aging
  • Ovarian reserve
  • Reproductive lifespan

IGF1R

Comparison of mitochondrial transplantation by using a stamp-type multineedle injector and platelet-rich plasma therapy for hair aging in naturally aging mice.


Keywords

  • Aging mice
  • Hair growth
  • Mitochondrial transplantation
  • Pep-1
  • Platelet-rich plasma

IGFBP1

Role of IGFBP1 in the senescence of vascular endothelial cells and severity of aging‑related coronary atherosclerosis.


MeSH Terms

  • Adult
  • Aged
  • Aged, 80 and over
  • Aging
  • Atherosclerosis
  • Cells, Cultured
  • Cellular Senescence
  • Coronary Artery Disease
  • Coronary Vessels
  • Down-Regulation
  • Endothelial Cells
  • Female
  • Humans
  • Insulin-Like Growth Factor Binding Protein 1
  • Jagged-1 Protein
  • Male
  • Middle Aged
  • Signal Transduction
  • Up-Regulation

IGFBP2

Intracellular Insulin-like growth factor binding protein 2 (IGFBP2) contributes to the senescence of keratinocytes in psoriasis by stabilizing cytoplasmic p21.


Keywords

  • insulin-like growth factor binding protein 2
  • keratinocytes
  • p21CIP1/WAF1
  • psoriasis
  • senescence

IGFBP3

Cellular and Molecular Biomarkers Indicate Premature Aging in Pseudoxanthoma Elasticum Patients.


Keywords

  • CCL11
  • GDF11
  • IGF1
  • IGFBP
  • aging
  • pseudoxanthoma elasticum


Paracrine senescence of human endometrial mesenchymal stem cells: a role for the insulin-like growth factor binding protein 3.


Keywords

  • IGFBP3
  • endocytosis
  • endometrial stem cells
  • paracrine senescence
  • secretome

IGFBP4

Quantitative iTRAQ-based proteomic analysis of differentially expressed proteins in aging in human and monkey.


MeSH Terms

  • Adult
  • Aged
  • Aged, 80 and over
  • Aging
  • Animals
  • Cognition
  • Female
  • Gene Expression Regulation
  • Gene Regulatory Networks
  • Haplorhini
  • Humans
  • Insulin-Like Growth Factor Binding Protein 4
  • Male
  • Mice
  • Proteomics

Keywords

  • Cognitive dysfunction
  • IGFBP4
  • Plasma
  • Quantitative proteomics
  • iTRAQ

IGFBP7

Reprogramming of human fibroblasts into osteoblasts by insulin-like growth factor-binding protein 7.


Keywords

  • IGFBP7
  • IL-6
  • human fibroblast
  • osteoblast
  • reprogramming
  • senescence

IHH

Indian Hedgehog regulates senescence in bone marrow-derived mesenchymal stem cell through modulation of ROS/mTOR/4EBP1, p70S6K1/2 pathway.


Keywords

  • Indian hedgehog
  • aging
  • differentiation
  • mammalian target of rapamycin
  • mesenchymal stem cell

IL10

The beneficial effect of physical exercise on inflammatory makers in older individuals.


Keywords

  • IL-6 expression
  • Inflammatory markers
  • aerobic exercise
  • aging
  • plasma IL-6 levels
  • resistance training


Astrocyte senescence may drive alterations in GFAPα, CDKN2A p14 , and TAU3 transcript expression and contribute to cognitive decline.


MeSH Terms

  • Aged
  • Alternative Splicing
  • Astrocytes
  • Cells, Cultured
  • Cellular Senescence
  • Cognitive Dysfunction
  • Cytokines
  • Gene Expression
  • Glial Fibrillary Acidic Protein
  • Humans
  • Matrix Metalloproteinases
  • Transcription, Genetic
  • Tumor Suppressor Protein p14ARF
  • tau Proteins

Keywords

  • Alternative splicing
  • Gene expression
  • Neurodegenerative disease
  • Senescence


Dietary Spray-Dried Porcine Plasma Prevents Cognitive Decline in Senescent Mice and Reduces Neuroinflammation and Oxidative Stress.


MeSH Terms

  • Animals
  • Cognition Disorders
  • Encephalitis
  • Male
  • Mice
  • Oxidative Stress
  • Plasma
  • Swine

Keywords

  • aging
  • cognitive decline
  • dietary supplementation
  • neuroinflammation
  • spray-dried animal plasma

IL15

Moderate physical activity associated with a higher naïve/memory T-cell ratio in healthy old individuals: potential role of IL15.


Keywords

  • T cells
  • ageing
  • immune senescence
  • older people
  • physical activity

IL1A

IL1B triggers inflammatory cytokine production in bovine oviduct epithelial cells and induces neutrophil accumulation via CCL2.


Keywords

  • CCL2
  • cellular senescence
  • inflammaging
  • senescence-associated secretory phenotype

IL2

Impact of Aging on the Phenotype of Invariant Natural Killer T Cells in Mouse Thymus.


Keywords

  • IL2
  • aging
  • invariant natural killer T cells
  • thymus
  • transcriptome

IL6

Basic immunology may lead to translational therapeutic rationale: SARS-CoV-2 and rheumatic diseases.


MeSH Terms

  • Adaptive Immunity
  • Aged
  • Antirheumatic Agents
  • COVID-19
  • Comorbidity
  • Coronavirus Infections
  • Disease Outbreaks
  • Female
  • Humans
  • Hydroxychloroquine
  • Immunity, Innate
  • Immunologic Factors
  • Immunosuppressive Agents
  • Italy
  • Male
  • Middle Aged
  • Pandemics
  • Pneumonia, Viral
  • Rheumatic Diseases
  • Risk Assessment
  • Severe Acute Respiratory Syndrome

Keywords

  • COVID-19
  • SARS-CoV-2
  • geriatrics
  • pathophysiology
  • pediatrics
  • rheumatology


ATM-deficient neural precursors develop senescence phenotype with disturbances in autophagy.


Keywords

  • ATM
  • Ataxia-telangiectasia
  • Autophagy
  • Mitophagy
  • Neural progenitors
  • Oxidative stress
  • Senescence
  • hiPSCs


The microRNA-34a-Induced Senescence-Associated Secretory Phenotype (SASP) Favors Vascular Smooth Muscle Cells Calcification.


Keywords

  • IL6
  • SASP
  • VSMCs
  • inflammaging
  • senescence
  • vascular calcification


Impact of Influenza on Pneumococcal Vaccine Effectiveness during [i]Streptococcus pneumoniae[/i] Infection in Aged Murine Lung.


Keywords

  • Streptococcus pneumoniae
  • aging
  • influenza
  • vaccine effectiveness
  • viral immune imprinting


Patterns of multi-domain cognitive aging in participants of the Long Life Family Study.


Keywords

  • Aging
  • Biomarker
  • Cognition
  • Neuropsychology


Cholest-4,6-Dien-3-One Promote Epithelial-To-Mesenchymal Transition (EMT) in Biliary Tree Stem/Progenitor Cell Cultures In Vitro.


MeSH Terms

  • Biliary Tract
  • Cell Differentiation
  • Cell Proliferation
  • Cells, Cultured
  • Cellular Senescence
  • Cholestenones
  • Epithelial-Mesenchymal Transition
  • Histone Deacetylase 6
  • Humans
  • Interleukin-6
  • Signal Transduction
  • Stem Cells
  • Tissue Donors

Keywords

  • BMP pathway
  • SHH pathway
  • biliary tree stem/progenitor cells (BTSCs)
  • epithelial-to-mesenchymal transition (EMT)
  • primary sclerosing cholangitis (PSC)
  • senescence
  • telomerase


Single xenotransplant of rat brown adipose tissue prolonged the ovarian lifespan of aging mice by improving follicle survival.


MeSH Terms

  • Adipose Tissue, Brown
  • Animals
  • Cellular Senescence
  • Female
  • Longevity
  • Male
  • Mice
  • Ovarian Follicle
  • Ovary
  • Rats
  • Rats, Sprague-Dawley
  • Transplantation, Heterologous

Keywords

  • aging
  • brown adipose tissue (BAT)
  • lifespan
  • mice
  • ovary
  • rat
  • xenotransplant

ILDR1

Genome-wide association meta-analysis identifies five novel loci for age-related hearing impairment.


MeSH Terms

  • Aging
  • Animals
  • Auditory Pathways
  • Female
  • Gene Expression Regulation
  • Genetic Loci
  • Genetic Predisposition to Disease
  • Genome-Wide Association Study
  • Hearing Loss
  • Humans
  • Male
  • Mice
  • Middle Aged
  • Molecular Sequence Annotation
  • Phenotype
  • Reproducibility of Results

IMPACT

Load-dependent modulation of alpha oscillations during working memory encoding and retention in young and older adults.


Keywords

  • EEG
  • alpha oscillations
  • cognitive aging
  • working memory


Using Video Telehealth to Deliver Patient-Centered Collaborative Care: The G-IMPACT Pilot.


Keywords

  • Telehealth
  • aging
  • care coordination
  • home care
  • interdisciplinary
  • medicine
  • older adult
  • video


AGING, HEART RATE VARIABILITY AND METABOLIC IMPACT OF OBESITY.


MeSH Terms

  • Aging
  • Autonomic Nervous System
  • Autonomic Nervous System Diseases
  • Female
  • Heart Rate
  • Humans
  • Male
  • Metabolic Diseases
  • Metabolism
  • Middle Aged
  • Obesity

Keywords

  • Aging
  • Autonomic nervous system
  • Heart rate
  • Obesity, metabolically benign
  • Parasympathetic nervous system
  • Sympathetic nervous system

INS

Melatonin protects INS-1 pancreatic β-cells from apoptosis and senescence induced by glucotoxicity and glucolipotoxicity.


Keywords

  • Melatonin
  • Senescence
  • glucolipotoxicity
  • glucotoxicity
  • pancreatic β-cell


Nicotine triggers islet β cell senescence to facilitate the progression of type 2 diabetes.


MeSH Terms

  • Animals
  • Blotting, Western
  • Calcium
  • Cellular Senescence
  • Diabetes Mellitus, Type 2
  • Disease Progression
  • Dose-Response Relationship, Drug
  • Enzyme-Linked Immunosorbent Assay
  • Glucose
  • Insulin-Secreting Cells
  • Male
  • Mice
  • Mice, Inbred C57BL
  • Nicotine
  • Reactive Oxygen Species
  • Real-Time Polymerase Chain Reaction
  • beta-Galactosidase

Keywords

  • ROS
  • islet β cells
  • nicotine
  • senescence
  • type 2 diabetes

INSL3

Effect of Thyroxine Replacement on Leydig Cell and Sertoli Cell Function in Men with Hypothyroidism.


Keywords

  • Androgen deficiency in aging male
  • arizona sexual experience scale
  • hypothyroidism
  • inhibin B
  • insulin-like factor 3
  • semen analysis
  • sperm motility

IP6K1

The Role of the IGF-1 Signaling Cascade in Muscle Protein Synthesis and Anabolic Resistance in Aging Skeletal Muscle.


Keywords

  • Akt
  • IP6K1
  • aging
  • anabolic resistance
  • mTOR
  • protein
  • resistance exercise
  • sarcopenia

IQGAP1

IQGAP1-dysfunction leads to induction of senescence in human vascular smooth muscle cells.


Keywords

  • Cellular bridges (CBs)
  • IQGAP1
  • Intercellular communication
  • Senescence
  • Tunneling nanotubes (TNTs)
  • Vascular smooth muscle cells (VSMCs)


Hyaluronan-binding protein 1 (HABP1) overexpression triggers induction of senescence in fibroblasts cells.


Keywords

  • F-HABP07
  • HABP1
  • IQGAP1
  • senescence

IRF8

IRF8 induces senescence of lung cancer cells to exert its tumor suppressive function.


MeSH Terms

  • A549 Cells
  • Animals
  • Carcinogenesis
  • Carcinoma, Non-Small-Cell Lung
  • Cell Movement
  • Cell Proliferation
  • Cellular Senescence
  • Gene Expression Regulation, Neoplastic
  • Heterografts
  • Humans
  • Interferon Regulatory Factors
  • Mice
  • Prognosis
  • Signal Transduction
  • Tumor Suppressor Proteins

Keywords

  • IRF8
  • NSCLC
  • cell cycle arrest
  • cell senescence
  • tumor suppresser gene

IRS1

MicroRNA-34a causes ceramide accumulation and effects insulin signaling pathway by targeting ceramide kinase (CERK) in aging skeletal muscle.


Keywords

  • CERK
  • aging muscle
  • insulin signaling pathway
  • miR-34a


Longevity in response to lowered insulin signaling requires glycine N-methyltransferase-dependent spermidine production.


Keywords

  • IGF
  • aging
  • autophagy
  • insulin
  • lifespan
  • metabolism
  • polyamine


Serine Phosphorylation of IRS1 Correlates with Aβ-Unrelated Memory Deficits and Elevation in Aβ Level Prior to the Onset of Memory Decline in AD.


MeSH Terms

  • Aging
  • Alzheimer Disease
  • Amyloid beta-Peptides
  • Amyloid beta-Protein Precursor
  • Animals
  • Brain
  • Diabetes Mellitus, Type 2
  • Humans
  • Insulin
  • Insulin Receptor Substrate Proteins
  • Male
  • Memory
  • Memory Disorders
  • Mice, Inbred C57BL
  • Mice, Transgenic
  • Phosphorylation
  • Serine
  • Signal Transduction

Keywords

  • AMPK
  • Alzheimer’s disease
  • IRS1
  • aging
  • diabetes
  • energy depletion
  • hippocampus
  • memory decline
  • serine phosphorylation

IRS2

Effects of Heshouwuyin on gene expression of the insulin/IGF signalling pathway in rat testis and spermatogenic cells.


Keywords

  • IGF1
  • IGFBP3
  • INSR
  • IRS1
  • IRS2
  • Male reproduction
  • senescence

ITGA3

A transcriptomic analysis of serial-cultured, tonsil-derived mesenchymal stem cells reveals decreased integrin α3 protein as a potential biomarker of senescent cells.


Keywords

  • AKT
  • Culture-aged
  • ECM-receptor protein
  • Integrin α3
  • Senescence
  • Serial passaging
  • Tonsil-derived mesenchymal stem cells
  • Transcriptome

ITGA5

Kaempferol alleviates the reduction of developmental competence during aging of porcine oocytes.


MeSH Terms

  • Animals
  • Blastocyst
  • Cellular Senescence
  • Embryo Culture Techniques
  • Embryo, Mammalian
  • Embryonic Development
  • Female
  • Integrins
  • Kaempferols
  • Mitochondria
  • Nanog Homeobox Protein
  • Octamer Transcription Factor-3
  • Oocytes
  • Oxidative Stress
  • RNA, Messenger
  • Reactive Oxygen Species
  • Swine

Keywords

  • embryonic development
  • kaempferol
  • oocyte aging
  • porcine

ITGAM

Comparative Analysis of Gene Expression Patterns for Oral Epithelium-Related Functions with Aging.


MeSH Terms

  • Aging
  • Animals
  • Disease Models, Animal
  • Epithelial Cells
  • Gingiva
  • Macaca mulatta
  • Oligonucleotide Array Sequence Analysis
  • Transcriptome

IVD

MicroRNAs in Intervertebral Disc Degeneration, Apoptosis, Inflammation, and Mechanobiology.


Keywords

  • ECM
  • MMP
  • annulus fibrosus
  • cartilaginous endplate
  • degenerative disc disease
  • miRNA
  • nucleus pulposus
  • senescence


A step-by-step protocol for isolation of murine nucleus pulposus cells.


Keywords

  • aging
  • gene expression
  • intervertebral disc degeneration
  • nucleus pulposus


Caspase-3 knockout inhibits intervertebral disc degeneration related to injury but accelerates degeneration related to aging.


MeSH Terms

  • Aging
  • Animals
  • Annulus Fibrosus
  • Apoptosis
  • Biomarkers
  • Carcinogenesis
  • Caspase 3
  • Cell Count
  • Extracellular Matrix
  • Intervertebral Disc
  • Intervertebral Disc Degeneration
  • Mice, Inbred C57BL
  • Mice, Knockout
  • Nucleus Pulposus
  • Up-Regulation


Finite element and deformation analyses predict pattern of bone failure in loaded zebrafish spines.


MeSH Terms

  • Aging
  • Animals
  • Back Pain
  • Disease Models, Animal
  • Finite Element Analysis
  • Humans
  • Intervertebral Disc
  • Movement
  • Weight-Bearing
  • Zebrafish

Keywords

  • deformation
  • finite element
  • geometric morphometrics
  • mechanics
  • spine
  • zebrafish


Improvement in determining the risk of damage to the human lumbar functional spinal unit considering age, height, weight and sex using a combination of FEM and RSM.


MeSH Terms

  • Adult
  • Age Factors
  • Aging
  • Analysis of Variance
  • Biomechanical Phenomena
  • Body Height
  • Body Mass Index
  • Body Weight
  • Cortical Bone
  • Female
  • Finite Element Analysis
  • Humans
  • Imaging, Three-Dimensional
  • Intervertebral Disc
  • Lumbar Vertebrae
  • Male
  • Models, Biological
  • Range of Motion, Articular
  • Risk Factors
  • Sex Characteristics

Keywords

  • Age
  • Biomechanics
  • Body mass index (BMI)
  • Finite element method (FEM)
  • Functional spinal unit (FSU)
  • Height
  • Response surface method (RSM)
  • Sex
  • Weight


In vivo contrast-enhanced microCT for the monitoring of mouse thoracic, lumbar, and coccygeal intervertebral discs.


Keywords

  • Contrast‐enhanced microCT
  • aging
  • intervertebral disc
  • mouse model

JAK1

Irradiation-induced senescence of bone marrow mesenchymal stem cells aggravates osteogenic differentiation dysfunction via paracrine signaling.


MeSH Terms

  • Bone Resorption
  • Cell Cycle Checkpoints
  • Cell Differentiation
  • Cell Proliferation
  • Cellular Senescence
  • DNA Damage
  • Gene Expression Regulation, Developmental
  • Histones
  • Humans
  • Janus Kinase 1
  • Mesenchymal Stem Cells
  • Mitochondria
  • Osteogenesis
  • Paracrine Communication
  • Radiation
  • Reactive Oxygen Species
  • STAT3 Transcription Factor
  • Signal Transduction

Keywords

  • SASP
  • bone marrow mesenchymal stem cells
  • cellular senescence
  • irradiation
  • osteogenic differentiation


The Upregulation of Toll-Like Receptor 3 via Autocrine IFN-β Signaling Drives the Senescence of Human Umbilical Cord Blood-Derived Mesenchymal Stem Cells Through JAK1.


MeSH Terms

  • Autocrine Communication
  • Cellular Senescence
  • Fetal Blood
  • Humans
  • Interleukin-6
  • Janus Kinase 1
  • Mesenchymal Stem Cells
  • Toll-Like Receptor 3
  • Up-Regulation

Keywords

  • Janus kinase 1 (JAK1)
  • Toll-like receptor 3 (TLR3)
  • interferon-β (IFN-β)
  • mesenchymal stromal cell (MSC)
  • senescence

JAK2

Senescence in Monocytes Facilitates Dengue Virus Infection by Increasing Infectivity.


Keywords

  • DC-SIGN
  • IL-10
  • dengue virus
  • monocytes
  • senescence


Quercetin Directly Targets JAK2 and PKCδ and Prevents UV-Induced Photoaging in Human Skin.


MeSH Terms

  • Antioxidants
  • Cell Line
  • Cells, Cultured
  • Cyclooxygenase 2
  • Humans
  • Janus Kinase 2
  • MAP Kinase Signaling System
  • Matrix Metalloproteinase 1
  • NF-kappa B
  • Protein Kinase C-delta
  • Quercetin
  • STAT3 Transcription Factor
  • Skin
  • Skin Aging
  • Transcription Factor AP-1
  • Ultraviolet Rays

Keywords

  • JAK2
  • PKC-delta
  • quercetin
  • skin aging


[Red blood cell lifespan detected by endogenous carbon monoxide breath test in patients with polycythemia vera].


MeSH Terms

  • Adult
  • Aged
  • Aged, 80 and over
  • Breath Tests
  • Carbon Monoxide
  • Case-Control Studies
  • Erythrocyte Count
  • Erythrocytes
  • Female
  • Humans
  • Janus Kinase 2
  • Longevity
  • Male
  • Middle Aged
  • Polycythemia Vera

Keywords

  • Carbon monoxide breath test
  • Polycythemia vera
  • Red blood cell lifespan


Roles of JAK2 in Aging, Inflammation, Hematopoiesis and Malignant Transformation.


MeSH Terms

  • Aging
  • Animals
  • Hematopoiesis
  • Humans
  • Inflammation
  • Janus Kinase 2
  • Mice
  • Myeloproliferative Disorders
  • Neoplasms

Keywords

  • JAK2
  • Janus-kinase
  • aging
  • clonal hematopoiesis (CHIP), myeloproliferative neoplasia (MPN)

JUN

Age-Onset Phosphorylation of a Minor Actin Variant Promotes Intestinal Barrier Dysfunction.


MeSH Terms

  • Actin Cytoskeleton
  • Actins
  • Aging
  • Animals
  • Binding Sites
  • Caenorhabditis elegans
  • Caenorhabditis elegans Proteins
  • Intercellular Junctions
  • Intestinal Mucosa
  • JNK Mitogen-Activated Protein Kinases
  • Phosphorylation
  • Protein Phosphatase 1
  • Transcription Factors
  • Troponin

Keywords

  • HSF-1
  • actin
  • aging
  • barrier
  • intestine
  • junctions
  • kinase
  • pathogenesis
  • phosphorylation
  • stress

JUNB

Promotion of cellular senescence by THG-1/TSC22D4 knockout through activation of JUNB.


MeSH Terms

  • Cell Line, Tumor
  • Cell Proliferation
  • Cellular Senescence
  • Cyclin-Dependent Kinase Inhibitor p21
  • Gene Expression Regulation, Neoplastic
  • Gene Knockout Techniques
  • HEK293 Cells
  • Humans
  • Transcription Factors
  • Transcription, Genetic
  • Up-Regulation

Keywords

  • Cellular senescence
  • JUNB
  • P21(CDKN1A)
  • THG-1(TSC22D4)

KAT6B

Aging-associated decrease in the histone acetyltransferase KAT6B is linked to altered hematopoietic stem cell differentiation.


MeSH Terms

  • Aging
  • Animals
  • Cell Differentiation
  • Epigenesis, Genetic
  • Erythroid Cells
  • Gene Expression Profiling
  • Gene Expression Regulation, Enzymologic
  • Gene Knockout Techniques
  • Histone Acetyltransferases
  • Male
  • Mice
  • Mice, Transgenic
  • Myeloid Progenitor Cells
  • Transcriptome

KCNK2

Brain age prediction using deep learning uncovers associated sequence variants.


MeSH Terms

  • Adolescent
  • Adult
  • Aged
  • Aged, 80 and over
  • Aging
  • Brain
  • Databases, Factual
  • Deep Learning
  • Genome-Wide Association Study
  • Humans
  • Iceland
  • Magnetic Resonance Imaging
  • Middle Aged
  • Neural Networks, Computer
  • Neuropsychological Tests
  • Polymorphism, Single Nucleotide
  • United Kingdom
  • Young Adult

KCNQ4

Guanylyl Cyclase A/cGMP Signaling Slows Hidden, Age- and Acoustic Trauma-Induced Hearing Loss.


Keywords

  • KCNQ4
  • PARP-1
  • aging
  • cGMP
  • guanylyl cyclase A
  • hidden hearing loss
  • inner ear
  • otoprotection

KCTD12

The association between poverty and gene expression within peripheral blood mononuclear cells in a diverse Baltimore City cohort.


MeSH Terms

  • Adult
  • Demography
  • Female
  • Gene Expression Profiling
  • Humans
  • Longevity
  • Male
  • Metabolic Networks and Pathways
  • Middle Aged
  • Monocytes
  • Poverty
  • Transcriptome
  • Urban Population

KDM2A

SIRT6 mono-ADP ribosylates KDM2A to locally increase H3K36me2 at DNA damage sites to inhibit transcription and promote repair.


Keywords

  • DNA repair
  • SIRT6
  • genome stability
  • longevity
  • transcription

KDM2B

Identification of Structural Elements of the Lysine Specific Demethylase 2B CxxC Domain Associated with Replicative Senescence Bypass in Primary Mouse Cells.


Keywords

  • Lysine demethylase
  • Non-methylated CpG
  • Oncogene
  • Polycomb repressive complex
  • Replicative senescence
  • Zn-finger

KDM3A

KDM3A and KDM4C Regulate Mesenchymal Stromal Cell Senescence and Bone Aging via Condensin-mediated Heterochromatin Reorganization.


Keywords

  • Cell Biology
  • DNA damage
  • Molecular Mechanism of Gene Regulation
  • Stem Cells Research
  • bone aging
  • condensin
  • epigenetic regulation
  • histone demethylase
  • mesenchymal stromal cells

KEAP1

NRF2 pathway activation by KEAP1 inhibition attenuates the manifestation of aging phenotypes in salivary glands.


Keywords

  • Aging
  • KEAP1
  • Mouse
  • NRF2
  • Salivary glands


Adaptation of the master antioxidant response connects metabolism, lifespan and feather development pathways in birds.


MeSH Terms

  • Adaptation, Physiological
  • Animals
  • Antioxidants
  • Basal Metabolism
  • Biological Evolution
  • Birds
  • Cell Nucleus
  • Feathers
  • Fibroblasts
  • Genomics
  • Glutathione Transferase
  • HEK293 Cells
  • Humans
  • Kelch-Like ECH-Associated Protein 1
  • Longevity
  • NF-E2-Related Factor 2
  • Oxidative Stress
  • Phylogeny
  • Proteasome Endopeptidase Complex
  • Protein Binding
  • Protein Transport
  • Ubiquitination
  • Up-Regulation

KIN

The noncanonical small heat shock protein HSP-17 from [i]Caenorhabditis elegans[/i] is a selective protein aggregase.


MeSH Terms

  • Animals
  • Caenorhabditis elegans
  • Caenorhabditis elegans Proteins
  • Casein Kinase I
  • Heat-Shock Proteins, Small
  • Longevity
  • Malate Dehydrogenase
  • Peptides
  • Protein Aggregates
  • Protein Folding
  • RNA Interference
  • RNA, Small Interfering
  • Recombinant Proteins

Keywords

  • Caenorhabditis elegans (C. elegans)
  • chaperone
  • protein aggregates
  • protein aggregation
  • protein folding
  • proteostasis
  • selective protein aggregase
  • small heat shock protein (sHsp)

KIT

Prediction of ovarian aging using ovarian expression of BMP15, GDF9, and C-KIT.


Keywords

  • BMP15
  • C-KIT
  • GDF9
  • Ovarian aging
  • biomarkers

KLF2

KLF2 induces the senescence of pancreatic cancer cells by cooperating with FOXO4 to upregulate p21.


MeSH Terms

  • Animals
  • Carcinogenesis
  • Cell Cycle Proteins
  • Cell Line
  • Cells, Cultured
  • Cellular Senescence
  • Cyclin-Dependent Kinase Inhibitor p21
  • Forkhead Transcription Factors
  • Kruppel-Like Transcription Factors
  • Male
  • Mice
  • Mice, Nude
  • Pancreatic Neoplasms
  • Protein Binding
  • Up-Regulation

Keywords

  • FOXO4
  • KLF2
  • Pancreatic cancer
  • Senescence

KLF4

Extracellular Vesicles from Healthy Cells Improves Cell Function and Stemness in Premature Senescent Stem Cells by miR-302b and HIF-1α Activation.


Keywords

  • aging
  • extracellular vesicles
  • oxygen
  • physiological oxygen concentration
  • physioxia
  • redox
  • senescence


Soluble klotho regulates the function of salivary glands by activating KLF4 pathways.


MeSH Terms

  • Animals
  • Cells, Cultured
  • Down-Regulation
  • Gene Expression Regulation
  • Glucuronidase
  • HEK293 Cells
  • Humans
  • Kruppel-Like Transcription Factors
  • Membrane Proteins
  • Mice
  • Mice, Knockout
  • Nuclear Proteins
  • RNA Interference
  • RNA, Small Interfering
  • Salivary Glands

Keywords

  • KLF4
  • aging
  • salivary gland
  • soluble klotho

KLF6

Krüppel-Like Factor 6 Is Required for Oxidative and Oncogene-Induced Cellular Senescence.


Keywords

  • DNA damage
  • KLF6
  • cell proliferation
  • cellular senescence
  • ras oncogene

KRAS

Chemical Pathology of Homocysteine VIII. Effects of Tocotrienol, Geranylgeraniol, and Squalene on Thioretinaco Ozonide, Mitochondrial Permeability, and Oxidative Phosphorylation in Arteriosclerosis, Cancer, Neurodegeneration and Aging.


Keywords

  • adenosine triphosphate
  • aging
  • antioxidant
  • apoptosis
  • atherogenesis
  • cancer
  • carcinogenesis
  • cholesterol
  • free radical
  • geraniol
  • geranylgeraniol
  • homocysteine
  • menoquinone
  • mitochondrial dysfunction
  • mitochondrial membrane potential
  • mitochondrial permeability transition pore
  • mitophagy
  • neuro-degeneration
  • oxidative phosphorylation
  • oxidative stress
  • squalene
  • statin
  • stellate cells
  • testosterone
  • thioretinaco ozonide
  • thioretinamide
  • tocopherol
  • tocotrienol
  • ubiquinone


Senescence-Induced Vascular Remodeling Creates Therapeutic Vulnerabilities in Pancreas Cancer.


MeSH Terms

  • Aging
  • Animals
  • CD8-Positive T-Lymphocytes
  • Carcinoma, Pancreatic Ductal
  • Cell Line, Tumor
  • Cell Proliferation
  • Cyclin-Dependent Kinase 4
  • Cyclin-Dependent Kinase 6
  • Gene Expression Regulation, Neoplastic
  • Genes, ras
  • Humans
  • Immunotherapy
  • MAP Kinase Signaling System
  • Mice
  • Pancreatic Neoplasms
  • Retinoblastoma Protein
  • Signal Transduction
  • Tumor Microenvironment
  • Vascular Remodeling

Keywords

  • T cells
  • chemotherapy resistance
  • endothelial cell activation
  • immunotherapy
  • pancreatic cancer
  • senescence
  • senescence-associated secretory phenotype
  • targeted therapy
  • tumor microenvironment
  • vascular biology

L1CAM

Glioma malignancy is linked to interdependent and inverse AMOG and L1 adhesion molecule expression.


MeSH Terms

  • Adenosine Triphosphatases
  • Apoptosis
  • Biomarkers
  • Brain Neoplasms
  • Cation Transport Proteins
  • Cell Adhesion
  • Cell Adhesion Molecules, Neuronal
  • Cell Line, Tumor
  • Cellular Senescence
  • Gene Expression Profiling
  • Gene Expression Regulation, Neoplastic
  • Glioblastoma
  • Humans
  • Immunohistochemistry
  • Neural Cell Adhesion Molecule L1
  • RNA, Small Interfering
  • Signal Transduction

Keywords

  • AMOG
  • Apoptosis
  • Glioma
  • Human
  • L1CAM
  • Senescence
  • Therapy

LAG3

T Cell Transcriptional Profiling and Immunophenotyping Uncover LAG3 as a Potential Significant Target of Immune Modulation in Multiple Myeloma.


Keywords

  • Autologous stem cell transplant
  • Exhaustion
  • LAG3
  • Multiple myeloma
  • Senescence

LAMP1

Differential accumulation of storage bodies with aging defines discrete subsets of microglia in the healthy brain.


Keywords

  • CLN3
  • TREM2
  • aging
  • autofluorescence
  • immunology
  • inflammation
  • lysosomal storage disorder
  • microglia
  • mouse
  • neuroscience
  • rhesus macaque

LBP

Lipopolysaccharide binding protein is associated with CVD risk in older adults.


Keywords

  • Aging
  • Cardiovascular disease risk
  • Intestinal permeability
  • Lipopolysaccharide binding protein


Aging-related liver degeneration is associated with increased bacterial endotoxin and lipopolysaccharide binding protein levels.


MeSH Terms

  • Acute-Phase Proteins
  • Aging
  • Animals
  • Apoptosis
  • Biomarkers
  • Carrier Proteins
  • Endotoxins
  • Female
  • Gene Expression Regulation
  • Glucose
  • Inflammation
  • Insulin Receptor Substrate Proteins
  • Liver
  • Liver Cirrhosis
  • Malate Dehydrogenase
  • Male
  • Membrane Glycoproteins
  • Mice
  • Mice, Inbred C57BL
  • Mice, Knockout
  • RNA, Messenger
  • Receptor, Insulin
  • Toll-Like Receptor 4

Keywords

  • Tlr-4 signaling
  • aging
  • bacterial endotoxin
  • lipopolysaccharide binding protein
  • liver degeneration


Biomarkers of leaky gut are related to inflammation and reduced physical function in older adults with cardiometabolic disease and mobility limitations.


MeSH Terms

  • Aged
  • Aging
  • Biomarkers
  • Exercise Therapy
  • Female
  • Follow-Up Studies
  • Humans
  • Inflammation
  • Male
  • Metabolic Syndrome
  • Middle Aged
  • Mobility Limitation
  • Motor Activity
  • Obesity
  • Retrospective Studies
  • Weight Loss

Keywords

  • Ageing
  • Lipopolysaccharide-binding protein
  • Microbial translocation
  • Physical function


Needle-shaped amyloid deposition in rat mammary gland: evidence of a novel amyloid fibril protein.


MeSH Terms

  • Aging
  • Amyloidogenic Proteins
  • Amyloidosis
  • Animals
  • Antigens, Surface
  • Female
  • Mammary Glands, Animal
  • Milk Proteins
  • Plaque, Amyloid
  • Rats
  • Rats, Sprague-Dawley

Keywords

  • Amyloidosis
  • lipopolysaccharide binding protein
  • mammary gland
  • pathology
  • rat


Effects of Lycium barbarum Polysaccharides on Health and Aging of [i]C. elegans[/i] Depend on [i]daf-12/daf-16[/i].


MeSH Terms

  • Aging
  • Animals
  • Caenorhabditis elegans
  • Caenorhabditis elegans Proteins
  • Drugs, Chinese Herbal
  • Receptors, Cytoplasmic and Nuclear

LBR

Lamin B receptor: role on chromatin structure, cellular senescence and possibly aging.


Keywords

  • Aging
  • cancer
  • cellular senescence
  • chromatine structure
  • nuclear envelop


The impact of age beyond ploidy: outcome data from 8175 euploid single embryo transfers.


Keywords

  • Aneuploidy
  • Pregestational genetic testing
  • Reproductive aging
  • Single embryo transfer


The role of lamin B receptor in the regulation of senescence-associated secretory phenotype (SASP).


Keywords

  • Gene expression
  • LBR
  • SAHF
  • SASP
  • Senescence


Lamin B receptor plays a key role in cellular senescence induced by inhibition of the proteasome.


Keywords

  • LBR
  • autophagy
  • proteasome
  • protein accumulation
  • senescence
  • unbalanced growth

LEP

Age- and Sex-Specific Changes in Lower-Limb Muscle Power Throughout the Lifespan.


Keywords

  • Aging
  • Body mass index
  • Dynapenia
  • Leg extension power
  • Sarcopenia
  • Skeletal muscle


The Copenhagen Sarcopenia Study: lean mass, strength, power, and physical function in a Danish cohort aged 20-93 years.


MeSH Terms

  • Adult
  • Aged
  • Aged, 80 and over
  • Body Composition
  • Cohort Studies
  • Cross-Sectional Studies
  • Denmark
  • Female
  • Hand Strength
  • Humans
  • Leg
  • Longevity
  • Middle Aged
  • Prospective Studies
  • Sarcopenia
  • Young Adult

Keywords

  • Body composition
  • DXA
  • Handgrip strength
  • Lean mass
  • Leg power
  • Sarcopenia

LGR6

Effect of defensins-containing eye cream on periocular rhytids and skin quality.


Keywords

  • aging
  • defensins
  • periocular
  • rhytids
  • skin

LHCGR

Comparative Study of the Steroidogenic Effects of Human Chorionic Gonadotropin and Thieno[2,3-D]pyrimidine-Based Allosteric Agonist of Luteinizing Hormone Receptor in Young Adult, Aging and Diabetic Male Rats.


Keywords

  • aging rats
  • diabetes mellitus
  • human chorionic gonadotropin
  • low-molecular-weight agonist
  • luteinizing hormone receptor
  • spermatogenesis
  • steroidogenesis
  • testes

LMNA

Metformin alters peripheral blood mononuclear cells (PBMC) senescence biomarkers gene expression in type 2 diabetic patients.


Keywords

  • Inflammation and cellular senescence
  • Insulin resistance
  • LMNA/C transcript variants
  • Mononuclear cells
  • Type 2 diabetes mellitus


Protein structural and mechanistic basis of progeroid laminopathies.


Keywords

  • 3D structure
  • aging disorders
  • contact sites
  • lamin
  • nuclear structure


Progerin Expression Induces Inflammation, Oxidative Stress and Senescence in Human Coronary Endothelial Cells.


Keywords

  • Hutchinson–Gilford progeria syndrome
  • LMNA
  • aging
  • atherosclerosis
  • endothelial dysfunction
  • inflammation
  • lamin A
  • prenylation
  • progerin


The JAK1/2 inhibitor ruxolitinib delays premature aging phenotypes.


Keywords

  • JAK/STAT pathway
  • cellular senescence
  • progeria
  • ruxolitinib


Pharmacotherapy to gene editing: potential therapeutic approaches for Hutchinson-Gilford progeria syndrome.


Keywords

  • Aging
  • Extracellular vesicles
  • Hutchinson–Gilford progeria syndrome
  • Progerin
  • Stem cells
  • Therapeutics


Long term breeding of the Lmna G609G progeric mouse: Characterization of homozygous and heterozygous models.


Keywords

  • Aging
  • Animal model breeding
  • Bone strength
  • Hutchinson-Gilford Progeria Syndrome (HGPS)
  • Kyphosis
  • Quality of life

LMNB1

SIRT1 - a new mammalian substrate of nuclear autophagy.


Keywords

  • Aging
  • SIRT1
  • nuclear autophagy
  • senescence
  • sirtuin


Cellular senescence as a response to multiwalled carbon nanotube (MWCNT) exposure in human mesothelial cells.


Keywords

  • alpha tubulin
  • cellular senescence
  • mesothelial cells
  • microarray analysis
  • multiwalled carbon nanotubes
  • γH2A.X


Inflammatory Drivers of Cardiovascular Disease: Molecular Characterization of Senescent Coronary Vascular Smooth Muscle Cells.


Keywords

  • aging
  • cardiovascular
  • inflammation
  • senescence
  • smooth muscle cell

LOX

12-LOX catalyzes the oxidation of 2-arachidonoyl-lysolipids in platelets generating eicosanoid-lysolipids that are attenuated by iPLA γ knockout.


Keywords

  • 2-arachidonoyl-lysophospholipids
  • aging
  • calcium
  • eicosanoid
  • iPLA2γ
  • lysophospholipid
  • myocardium
  • platelet
  • platelet-type 12-lipoxygenase (12-LOX)
  • polyunsaturated fatty acids (PUFAs)

LOXL1

A blackberry-dill extract combination synergistically increases skin elasticity.


Keywords

  • blackberry-dill
  • elasticity
  • skin aging
  • skin physiology/structure
  • skin repair

LOXL2

Lysyl Oxidase-Like 2 Protects against Progressive and Aging Related Knee Joint Osteoarthritis in Mice.


MeSH Terms

  • Adenoviridae
  • Aging
  • Amino Acid Oxidoreductases
  • Animals
  • Arthritis, Experimental
  • Cartilage, Articular
  • Disease Models, Animal
  • Disease Progression
  • Gene Expression
  • Gene Transfer Techniques
  • Genetic Vectors
  • Interleukin-1beta
  • Mice
  • Mice, Transgenic
  • NF-kappa B
  • Osteoarthritis, Knee
  • Transduction, Genetic

Keywords

  • Lysyl oxidase like-2
  • adenovirus delivery
  • anabolic response
  • articular cartilage
  • knee joint
  • osteoarthritis
  • regeneration

LPA

Ginseng gintonin, aging societies, and geriatric brain diseases.


Keywords

  • Brain aging
  • Gintonin
  • Neurodegenerative diseases
  • Panax ginseng
  • Rejuvenation


Late-life related subtypes of depression - a data-driven approach on cognitive domains and physical frailty.


Keywords

  • cognitive aging
  • depression
  • frailty


Does sedentary time increase in older adults in the days following participation in intense exercise?


MeSH Terms

  • Accelerometry
  • Aged
  • Exercise
  • Exercise Test
  • Humans
  • Sedentary Behavior
  • Sleep

Keywords

  • Aging
  • Compensation
  • High intensity
  • Movement behaviours


Association of Long-term Exposure to Elevated Lipoprotein(a) Levels With Parental Life Span, Chronic Disease-Free Survival, and Mortality Risk: A Mendelian Randomization Analysis.


MeSH Terms

  • Aged
  • Case-Control Studies
  • Cross-Sectional Studies
  • Female
  • Humans
  • Lipoprotein(a)
  • Longevity
  • Male
  • Mendelian Randomization Analysis
  • Middle Aged
  • Parents
  • Phenotype
  • Prospective Studies
  • Risk Factors


Elevated Autotaxin and LPA Levels During Chronic Viral Hepatitis and Hepatocellular Carcinoma Associate with Systemic Immune Activation.


Keywords

  • Aging
  • Autotaxin
  • Hepatitis
  • Hepatocellular Carcinoma
  • Immune Activation
  • Immunity
  • Inflammation
  • Liver
  • Lysophosphatidic Acid


Lysophosphatidic acid receptor LPA prevents oxidative stress and cellular senescence in Hutchinson-Gilford progeria syndrome.


Keywords

  • 1-Oleoyl-2-O-methyl-rac-glycerophosphothionate
  • Hutchinson-Gilford progeria syndrome
  • LPA3
  • cell senescence
  • lysophosphatidic acid
  • reactive oxygen species


Associations of Sedentary and Physically-Active Behaviors With Cognitive-Function Decline in Community-Dwelling Older Adults: Compositional Data Analysis From the NEIGE Study.


Keywords

  • accelerometry
  • aging
  • exercise
  • neurocognitive disorders
  • sedentary lifestyle


Validation and comparison of two automated methods for quantifying brain white matter hyperintensities of presumed vascular origin.


Keywords

  • White matter hyperintensity
  • brain aging
  • cerebral small vessel disease
  • lesion segmentation
  • methodology
  • validation


The Sedentary Time and Physical Activity Levels on Physical Fitness in the Elderly: A Comparative Cross Sectional Study.


MeSH Terms

  • Accelerometry
  • Aged
  • Aged, 80 and over
  • Aging
  • Body Mass Index
  • Cross-Sectional Studies
  • Exercise
  • Female
  • Humans
  • Male
  • Physical Fitness
  • Sedentary Behavior

Keywords

  • accelerometry
  • ageing
  • health
  • physical fitness
  • sedentary behaviour


Light-Intensity Physical Activity in a Large Prospective Cohort of Older US Adults: A 21-Year Follow-Up of Mortality.


MeSH Terms

  • Aged
  • Cardiovascular Diseases
  • Cohort Studies
  • Exercise
  • Female
  • Follow-Up Studies
  • Humans
  • Leisure Activities
  • Male
  • Middle Aged
  • Mortality
  • Neoplasms
  • Proportional Hazards Models
  • Prospective Studies
  • Respiratory Tract Diseases
  • Risk Factors
  • Surveys and Questionnaires
  • United States

Keywords

  • Aging
  • Cancer prevention study
  • Leisure time physical activity
  • Light-intensity physical activity

LPL

Survival analyses in Holstein cows considering direct disease diagnoses and specific SNP marker effects.


Keywords

  • SNP effect
  • Weibull hazards model
  • genetic parameter
  • health disorder
  • longevity


Influence of common health disorders on the length of productive life and stayability in German Holstein cows.


MeSH Terms

  • Animals
  • Breeding
  • Cattle
  • Cattle Diseases
  • Dairying
  • Farmers
  • Female
  • Lactation
  • Longevity
  • Phenotype

Keywords

  • genetic parameter
  • health disorder
  • longevity
  • subjective culling reason

LPO

[Features of the changes in lipid peroxidation and activity of Na+/K+-ATPase in the brain of the aged rats in the conditions of two-vessel cerebral ischemia/reperfusion.]


MeSH Terms

  • Aging
  • Animals
  • Brain Ischemia
  • Disease Models, Animal
  • Lipid Peroxidation
  • Rats
  • Reperfusion Injury
  • Sodium-Potassium-Exchanging ATPase

Keywords

  • Na+/K+-ATPase
  • aging
  • brain
  • lipid peroxidation
  • oxidative stress
  • stroke

LRP1

Drug Targeting of Plasminogen Activator Inhibitor-1 Inhibits Metabolic Dysfunction and Atherosclerosis in a Murine Model of Metabolic Syndrome.


MeSH Terms

  • Animals
  • Atherosclerosis
  • Cellular Senescence
  • Diet, Western
  • Disease Models, Animal
  • Indoleacetic Acids
  • Macrophages
  • Metabolic Syndrome
  • Mice
  • Mice, Knockout
  • Obesity
  • Plaque, Atherosclerotic
  • Plasminogen Activator Inhibitor 1
  • Receptors, LDL

Keywords

  • atherosclerosis
  • cellular senescence
  • fibrinolysis
  • metabolic syndrome
  • muscle, smooth
  • obesity
  • plasminogen activator inhibitor-1

LRP4

Multiple MuSK signaling pathways and the aging neuromuscular junction.


Keywords

  • Aging
  • BMP signaling
  • MuSK
  • Neuromuscular junction
  • Synaptic maintenance

LRP6

Low-density lipoprotein receptor-related protein 6-mediated signaling pathways and associated cardiovascular diseases: diagnostic and therapeutic opportunities.


MeSH Terms

  • Aging
  • Animals
  • Cardiovascular Diseases
  • Humans
  • Low Density Lipoprotein Receptor-Related Protein-6
  • Muscle, Smooth, Vascular
  • Myocytes, Smooth Muscle
  • Obesity
  • Signal Transduction
  • Structure-Activity Relationship
  • Vascular Calcification
  • Wnt Signaling Pathway

LRRK2

Accelerated telomere shortening independent of LRRK2 variants in Chinese patients with Parkinson's disease.


Keywords

  • LRRK2 variants
  • Parkinson’s disease
  • aging
  • telomere length


The effect of LRRK2 loss-of-function variants in humans.


MeSH Terms

  • Adult
  • Aged
  • Aged, 80 and over
  • Biological Specimen Banks
  • Cell Line
  • Embryonic Stem Cells
  • Female
  • Gain of Function Mutation
  • Heterozygote
  • Humans
  • Leucine-Rich Repeat Serine-Threonine Protein Kinase-2
  • Longevity
  • Loss of Function Mutation
  • Lymphocytes
  • Male
  • Middle Aged
  • Myocytes, Cardiac
  • Parkinson Disease
  • Phenotype


Parkinson's disease-related Leucine-rich repeat kinase 2 modulates nuclear morphology and genomic stability in striatal projection neurons during aging.


Keywords

  • And aging
  • Dendritic hypotrophy
  • Excitability
  • G2019S
  • GABAA
  • LRRK2
  • Nuclear DNA damage
  • Nuclear hypertrophy
  • Nuclear invagination
  • Parkinson’s disease
  • R1441C
  • Striatal spiny projection neuron


Autophagy and LRRK2 in the Aging Brain.


Keywords

  • LAMP2A
  • LC3
  • LRRK2
  • Parkinson’s disease
  • aging
  • autophagy
  • lysosomes
  • α-synuclein

LSS

Surgical results in older patients with lumbar spinal stenosis according to gait speed in relation to the diagnosis for sarcopenia.


Keywords

  • aging
  • elderly person
  • gait speed
  • lumbar spinal stenosis
  • lumbar spine
  • muscle strength
  • sarcopenia
  • skeletal muscle mass
  • surgical result


Streamlining an existing hip fracture patient pathway in an acute tertiary adult Irish hospital to improve patient experience and outcomes.


MeSH Terms

  • Aged
  • Aged, 80 and over
  • Delivery of Health Care, Integrated
  • Geriatrics
  • Hip Fractures
  • Hospitals, Teaching
  • Humans
  • Ireland
  • Length of Stay
  • Nerve Block
  • Orthopedics
  • Pain Management
  • Total Quality Management
  • Treatment Outcome

Keywords

  • Lean Six Sigma
  • healthcare outcomes
  • hip fracture care
  • integrated care pathways
  • interdisciplinary working
  • process improvement

LTA

Lipoteichoic acid from the cell wall of a heat killed Lactobacillus paracasei D3-5 ameliorates aging-related leaky gut, inflammation and improves physical and cognitive functions: from C. elegans to mice.


Keywords

  • Aging
  • Cell wall
  • Cognition
  • Goblet cell
  • Inflammation
  • Leaky gut
  • Lipoteichoic acid
  • Metabolism
  • Mucin
  • Physical function
  • Probiotics


The change of pain classes over time: a latent transition analysis.


MeSH Terms

  • Aged
  • Aging
  • Humans
  • Life Style
  • Longitudinal Studies
  • Middle Aged
  • Pain
  • Quality of Life

LY6D

LY6D-induced macropinocytosis as a survival mechanism of senescent cells.


Keywords

  • LY6D
  • Ras protein
  • cellular senescence
  • endocytosis
  • lipid raft
  • macropinocytosis
  • vacuole

MAG

Exploration of life satisfaction of Korean people with sensory impairments across the lifespan.


Keywords

  • Across the lifespan
  • Leisure domain
  • Life satisfaction
  • Sensory impairment
  • Social domain

MALT1

MALT-1 mediates IL-17 neural signaling to regulate C. elegans behavior, immunity and longevity.


MeSH Terms

  • Animals
  • Behavior, Animal
  • Caenorhabditis elegans
  • Caenorhabditis elegans Proteins
  • Gene Expression Regulation
  • Green Fluorescent Proteins
  • Immunity
  • Interleukin-17
  • Interneurons
  • Longevity
  • Models, Biological
  • Mucosa-Associated Lymphoid Tissue Lymphoma Translocation 1 Protein
  • Neurons
  • Oxygen
  • Signal Transduction
  • Subcellular Fractions
  • Transgenes


MALT1-Deficient Mice Develop Atopic-Like Dermatitis Upon Aging.


MeSH Terms

  • Age Factors
  • Animals
  • CTLA-4 Antigen
  • Cytokines
  • Dermatitis, Atopic
  • Disease Models, Animal
  • Disease Susceptibility
  • Gene Expression
  • Genetic Predisposition to Disease
  • Immunoglobulin E
  • Lymphocyte Activation
  • Mice
  • Mice, Knockout
  • Mucosa-Associated Lymphoid Tissue Lymphoma Translocation 1 Protein
  • Skin
  • T-Lymphocyte Subsets

Keywords

  • MALT1
  • Th2
  • Tregs
  • aging
  • atopic dermatitis
  • lymphocytes
  • skin inflammation

MAP2

Protective effects of ischemic preconditioning against neuronal apoptosis and dendritic injury in the hippocampus are age-dependent.


Keywords

  • aging
  • diffusion tensor imaging
  • immunohistochemistry
  • ischemic preconditioning

MAP4K3

MAP4K3/GLK in autoimmune disease, cancer and aging.


MeSH Terms

  • Aging
  • Autoimmune Diseases
  • Humans
  • Neoplasms
  • Protein-Serine-Threonine Kinases

Keywords

  • Aging
  • Autoimmune disease
  • Autophagy
  • Cancer metastasis
  • HPK1
  • IL-17A
  • IQGAP1
  • MAP4K3 (GLK)
  • PKCθ
  • Verteporfin

MAPK1

Purified Vitexin Compound 1 Inhibits UVA-Induced Cellular Senescence in Human Dermal Fibroblasts by Binding Mitogen-Activated Protein Kinase 1.


Keywords

  • MAPK1
  • VB1
  • purified vitexin compound 1
  • senescence
  • skin photoaging

MAPKAPK2

Quantitative In Vivo Proteomics of Metformin Response in Liver Reveals AMPK-Dependent and -Independent Signaling Networks.


MeSH Terms

  • AMP-Activated Protein Kinases
  • Animals
  • Calcium
  • Cell Line
  • Endocytosis
  • HEK293 Cells
  • Homeostasis
  • Humans
  • Intracellular Signaling Peptides and Proteins
  • Liver
  • Metformin
  • Mice
  • Phosphorylation
  • Protein Kinase C
  • Protein-Serine-Threonine Kinases
  • Proteomics
  • Signal Transduction

Keywords

  • AMPK3
  • LKB1
  • PKD1
  • STIM1
  • aging
  • calcium
  • diabetes
  • kinases
  • liver
  • metformin

MAPT

Association of relative brain age with tobacco smoking, alcohol consumption, and genetic variants.


MeSH Terms

  • Aged
  • Aged, 80 and over
  • Aging
  • Alcohol Drinking
  • Biological Specimen Banks
  • Brain
  • Cognition
  • Female
  • Humans
  • Magnetic Resonance Imaging
  • Male
  • Middle Aged
  • Neuroimaging
  • Polymorphism, Single Nucleotide
  • Smoking
  • United Kingdom
  • tau Proteins


A blood-based nutritional risk index explains cognitive enhancement and decline in the multidomain Alzheimer prevention trial.


Keywords

  • Aging
  • Biomarkers of diet quality
  • Cognitive decline
  • DHA
  • EPA
  • Elderly
  • Homocysteine
  • Metabolomics
  • Nutrient biomarkers
  • Omega-3 fatty acids
  • Vitamin D


Longitudinal associations of physical activity levels with morphological and functional changes related with aging: The MAPT study.


MeSH Terms

  • Aged
  • Aged, 80 and over
  • Aging
  • Alzheimer Disease
  • Body Composition
  • Brain
  • Cognition
  • Exercise
  • Female
  • Humans
  • Longitudinal Studies
  • Male

Keywords

  • Aging
  • Biomarkers
  • Phenotype
  • Physical activity


Ageing and amyloidosis underlie the molecular and pathological alterations of tau in a mouse model of familial Alzheimer's disease.


MeSH Terms

  • Aging
  • Alzheimer Disease
  • Amyloid beta-Peptides
  • Amyloidosis
  • Animals
  • Disease Models, Animal
  • Mice
  • Mice, Transgenic
  • tau Proteins


Revisiting the intersection of amyloid, pathologically modified tau and iron in Alzheimer's disease from a ferroptosis perspective.


Keywords

  • Alzheimer’s disease
  • Ferroptosis
  • Iron
  • Reactive oxygen species
  • Senescence
  • Tau

MATN3

Mice Lacking the Matrilin Family of Extracellular Matrix Proteins Develop Mild Skeletal Abnormalities and Are Susceptible to Age-Associated Osteoarthritis.


MeSH Terms

  • Aging
  • Animals
  • Cell Proliferation
  • Cells, Cultured
  • Chondrocytes
  • Disease Models, Animal
  • Female
  • Gene Knockout Techniques
  • Humans
  • Male
  • Matrilin Proteins
  • Mice
  • Mice, Knockout
  • Microscopy, Atomic Force
  • Muscle, Skeletal
  • Osteoarthritis

Keywords

  • articular cartilage
  • bone development
  • cartilage
  • matrilin
  • osteoarthritis

MB

Probing menstrual bloodstain aging with fluorescence spectroscopy.


Keywords

  • Aging
  • Analytical methods
  • Blood
  • Fluorescence spectroscopy
  • Forensics


Effect of physical exercise and medication on enhancing cognitive function in older adults with vascular risk.


MeSH Terms

  • Aged
  • Aged, 80 and over
  • Cognition
  • Cross-Sectional Studies
  • Exercise
  • Exercise Therapy
  • Female
  • Humans
  • Male
  • Middle Aged
  • Risk Factors
  • Vascular Diseases

Keywords

  • active aging
  • cognitive preservation
  • exercise habit
  • lifestyle advice
  • vascular care


A novel indenone derivative selectively induces senescence in MDA-MB-231 (breast adenocarcinoma) cells.


MeSH Terms

  • Antineoplastic Agents
  • Breast Neoplasms
  • Catalysis
  • Cell Line, Tumor
  • Cell Survival
  • Cellular Senescence
  • Cyclin-Dependent Kinase Inhibitor p21
  • Down-Regulation
  • Female
  • G1 Phase Cell Cycle Checkpoints
  • Humans
  • Palladium
  • Sulfonamides
  • Survivin
  • Tumor Suppressor Protein p53
  • Up-Regulation

Keywords

  • Cell cycle arrest
  • Novel indenone derivative
  • Senescence
  • Triple-negative breast cancer


Improved Autophagic Flux in Escapers from Doxorubicin-Induced Senescence/Polyploidy of Breast Cancer Cells.


Keywords

  • DNA damage
  • Rubicon
  • SQSTM1/p62
  • TFEB
  • autophagic index
  • autophagy
  • cancer
  • polyploidy
  • senescence
  • senescence escape


Lifespan regulation in α/β posterior neurons of the fly mushroom bodies by Rab27.


Keywords

  • Drosophila
  • Rab27
  • S6K
  • TOR
  • lifespan extension
  • mushroom body


Tailored Functionalized Magnetic Nanoparticles to Target Breast Cancer Cells Including Cancer Stem-Like Cells.


Keywords

  • apoptosis
  • cancer stem-like cells
  • doxorubicin
  • magnetic iron oxide nanoparticles
  • mitotic catastrophe
  • senescence


"Mitotic Slippage" and Extranuclear DNA in Cancer Chemoresistance: A Focus on Telomeres.


Keywords

  • ALT
  • SQSTM1/p62
  • amoeboid conversion
  • budding of mitotic progeny
  • cellular senescence
  • extranuclear DNA
  • genotoxic treatment
  • inverted meiosis
  • mtTP53 cancer
  • polyploidization


Diversity of the Senescence Phenotype of Cancer Cells Treated with Chemotherapeutic Agents.


MeSH Terms

  • Antineoplastic Agents
  • Cell Proliferation
  • Cellular Senescence
  • Cyclin-Dependent Kinase Inhibitor p21
  • Doxorubicin
  • Fluorouracil
  • Humans
  • Irinotecan
  • Methotrexate
  • Neoplasms
  • Oxaliplatin
  • Paclitaxel
  • Phenotype
  • Tumor Cells, Cultured

Keywords

  • DNA damage
  • SASP
  • cancer
  • chemotherapy
  • senescence
  • senescence markers


Downregulation of the inflammatory network in senescent fibroblasts and aging tissues of the long-lived and cancer-resistant subterranean wild rodent, Spalax.


Keywords

Spalax

  • DNA damage
  • DNA repair
  • cellular senescence
  • interleukin-1 alpha (IL1α)
  • nuclear factor κB (NF-κB)
  • senescence-associated secretory phenotype (SASP)


Quantification of the health-status of the Dutch Labrador retriever population.


MeSH Terms

  • Animals
  • Dog Diseases
  • Dogs
  • Female
  • Health Status
  • Insurance
  • Laboratories
  • Longevity
  • Male
  • Netherlands
  • Proportional Hazards Models
  • Risk Factors

Keywords

  • Canine health
  • Data analysis
  • Health parameters
  • Labrador retriever
  • Lifespan
  • Oncology


Conjugated Physiological Resveratrol Metabolites Induce Senescence in Breast Cancer Cells: Role of p53/p21 and p16/Rb Pathways, and ABC Transporters.


MeSH Terms

  • ATP-Binding Cassette Transporters
  • Breast Neoplasms
  • Cell Cycle Checkpoints
  • Cellular Senescence
  • Cyclin-Dependent Kinase Inhibitor p16
  • Cyclin-Dependent Kinase Inhibitor p21
  • Female
  • Glucuronides
  • Humans
  • MCF-7 Cells
  • Resveratrol
  • Retinoblastoma Protein
  • Signal Transduction
  • Stilbenes
  • Tumor Suppressor Protein p53

Keywords

  • ABC transporters
  • breast cancer
  • deconjugation
  • resveratrol metabolites
  • senescence

MBP

Demyelination associated with chronic arsenic exposure in Wistar rats.


MeSH Terms

  • Aging
  • Amyloid beta-Protein Precursor
  • Animals
  • Arsenic Poisoning
  • Arsenites
  • Axons
  • Corpus Callosum
  • Demyelinating Diseases
  • Diffusion Tensor Imaging
  • Drinking Water
  • Immunohistochemistry
  • Male
  • Mitochondria
  • Myelin Basic Protein
  • Neurofilament Proteins
  • Prefrontal Cortex
  • Rats
  • Rats, Wistar
  • Sodium Compounds
  • White Matter

Keywords

  • Amyloid
  • Anisotropy
  • Arsenic
  • Axonal damage
  • DTI
  • Demyelination
  • Development
  • MRI
  • Microstructure
  • Mitochondria


Natural killer cells as participants in pathogenesis of rat experimental autoimmune encephalomyelitis (EAE): lessons from research on rats with distinct age and strain.


Keywords

  • EAE
  • NK cells
  • aging
  • dendritic cells
  • strain differences

MCC

Multiple chronic conditions and risk of cognitive impairment and dementia among older Americans: findings from the Aging, Demographics, and Memory Study (ADAMS).


Keywords

  • Aging
  • and memory study
  • cognitive impairment with no dementia
  • dementia
  • demographics
  • multimorbidity
  • multiple chronic conditions


Behaviour consistency is a sensitive tool for distinguishing the effects of aging on physical activity.


Keywords

  • Aging
  • Behaviour consistency
  • Heart rate
  • Physical activity
  • Treadmill running


Burden on Caregivers of Adults with Multiple Chronic Conditions: Intersectionality of Age, Gender, Education level, Employment Status, and Impact on Social Life.


Keywords

  • aging
  • analyse d’intersectionnalité
  • caregiver burden
  • fardeau de l’aidant
  • gender
  • interférence sociale
  • intersectionality analysis
  • maladies chroniques multiples
  • multiple chronic conditions
  • sexe
  • social interference
  • vieillissement

MCM9

MCM8- and MCM9 Deficiencies Cause Lifelong Increased Hematopoietic DNA Damage Driving p53-Dependent Myeloid Tumors.


MeSH Terms

  • Aging
  • Animals
  • Apoptosis
  • Bone Marrow
  • Cell Differentiation
  • Cell Proliferation
  • DNA Damage
  • Gene Expression Regulation, Leukemic
  • Hematologic Neoplasms
  • Mice
  • Mice, Knockout
  • Minichromosome Maintenance Proteins
  • Retinoblastoma Protein
  • Signal Transduction
  • Splenomegaly
  • Tumor Suppressor Protein p53

Keywords

  • DNA damage
  • DNA repair
  • MCM8
  • MCM9
  • cancer
  • hematopoiesis
  • homologous recombination
  • myelodysplastic syndrome

MCU

A rare case of Epstein-Barr virus-positive mucocutaneous ulcer that developed into an intestinal obstruction: a case report.


MeSH Terms

  • Aged, 80 and over
  • Colon, Transverse
  • Epstein-Barr Virus Infections
  • Herpesvirus 4, Human
  • Humans
  • Intestinal Mucosa
  • Intestinal Obstruction
  • Male
  • Ulcer

Keywords

  • Aging
  • Epstein–Barr virus-positive mucocutaneous ulcer (EBV-MCU)
  • Immunosuppression
  • Intestinal obstruction
  • Surgical resection


Inhibition of Mitochondrial Calcium Overload by SIRT3 Prevents Obesity- or Age-Related Whitening of Brown Adipose Tissue.


MeSH Terms

  • Adipocytes, Brown
  • Adipose Tissue, Brown
  • Aging
  • Animals
  • Calcium
  • Capsaicin
  • Gene Expression Regulation
  • Mice
  • Mice, Knockout
  • Mitochondria
  • Obesity
  • Sirtuin 3

MDH1

Oxidative Damage to the TCA Cycle Enzyme MDH1 Dysregulates Bioenergetic Enzymatic Activity in the Aged Murine Brain.


Keywords

  • DPM
  • MRM
  • TCA cycle
  • aging
  • brain

MDM2

SENEBLOC, a long non-coding RNA suppresses senescence via p53-dependent and independent mechanisms.


MeSH Terms

  • Aging
  • Animals
  • Carcinogenesis
  • Cyclin-Dependent Kinase Inhibitor p21
  • Gene Expression Regulation, Neoplastic
  • HCT116 Cells
  • Heterografts
  • Histone Deacetylases
  • Humans
  • Mice
  • Neoplasms
  • Protein Binding
  • RNA, Long Noncoding
  • Signal Transduction
  • Tumor Suppressor Protein p53


Disruption of Robo2-Baiap2 integrated signaling drives cystic disease.


MeSH Terms

  • Animals
  • Cell Differentiation
  • Cell Proliferation
  • Cellular Senescence
  • Cilia
  • Disease Models, Animal
  • Epithelial Cells
  • Humans
  • Kidney
  • Kidney Diseases, Cystic
  • Mice
  • Mice, Knockout
  • Nerve Tissue Proteins
  • Protein Binding
  • Protein Domains
  • Receptors, Immunologic
  • Signal Transduction
  • Tumor Suppressor Protein p53

Keywords

  • Cellular senescence
  • Development
  • Genetic diseases
  • Nephrology
  • Signal transduction


Senescence-induced immunophenotype, gene expression and electrophysiology changes in human amniocytes.


MeSH Terms

  • Amniocentesis
  • Amnion
  • Biomarkers
  • Cell Proliferation
  • Cells, Cultured
  • Cellular Senescence
  • Electrophysiological Phenomena
  • Female
  • Gene Expression Regulation
  • Humans
  • Immunophenotyping
  • Phenotype

Keywords

  • amniocyte
  • automated patch-clamp
  • flow cytometry
  • mesenchymal stem cell
  • qRT-PCR
  • replicative senescence
  • senescence-associated secretory phenotype

MED25

The [i]HAC1[/i] histone acetyltransferase promotes leaf senescence and regulates the expression of [i]ERF022[/i].


Keywords

  • ERF022
  • H3K9ac
  • HAC1
  • Mediator complex
  • histone acetylation
  • leaf senescence

MEFV

The grandfather's fever.


MeSH Terms

  • Age of Onset
  • Aged, 80 and over
  • Familial Mediterranean Fever
  • Female
  • Humans
  • Male
  • Pedigree
  • Pyrin

Keywords

  • Autoinflammatory diseases
  • FMF
  • Genetics
  • Geriatrics
  • Periodic fever

MEOX2

Reduced expression of microRNA-130a promotes endothelial cell senescence and age-dependent impairment of neovascularization.


Keywords

  • aging
  • angiogenesis
  • microRNA
  • neovascularization
  • senescence

MET

Self-rated health in relation to fruit and vegetable consumption and physical activity among older cancer survivors.


Keywords

  • Cancer survivorship
  • Epidemiology
  • Fruit and vegetable
  • Gerontology
  • Physical activity


Leisure-time physical activity volume, intensity, and duration from mid- to late-life in U.S. subpopulations by race and sex. The Atherosclerosis Risk In Communities (ARIC) Study.


Keywords

  • exercise
  • healthy aging
  • physical activity
  • retirement
  • successful aging


Repressive H3K9me2 protects lifespan against the transgenerational burden of COMPASS activity in [i]C. elegans[/i].


MeSH Terms

  • Animals
  • Caenorhabditis elegans
  • Caenorhabditis elegans Proteins
  • Heterochromatin
  • Histone-Lysine N-Methyltransferase
  • Histones
  • Inheritance Patterns
  • Jumonji Domain-Containing Histone Demethylases
  • Longevity
  • Lysine
  • Methylation
  • Mutation

Keywords

  • C. elegans
  • COMPASS
  • aging
  • chromatin
  • chromosomes
  • epigenetics
  • gene expression
  • genetics
  • genomics
  • heterochromatin
  • transgenerational inheritance


Influence of Anthropometrics on Step-Rate Thresholds for Moderate and Vigorous Physical Activity in Older Adults: Scientific Modeling Study.


Keywords

  • aging
  • cadence
  • physical activity intensity
  • public health
  • walking

MFI

The Influence of the Accelerated Aging Conditions on the Properties of Polyolefin Geogrids Used for Landfill Slope Reinforcement.


Keywords

  • HDPE
  • accelerated aging tests
  • decrease mechanical properties
  • degradation
  • geosynthetics
  • landfill
  • polyolefin


Changes in Physical Meat Traits, Protein Solubility, and the Microstructure of Different Beef Muscles during Post-Mortem Aging.


Keywords

  • aging
  • beef muscle
  • microstructure
  • myofibril fragmentation
  • protein solubility


Effect of a low-voltage electrical stimulation on yak meat tenderness during postmortem aging.


MeSH Terms

  • Animals
  • Cattle
  • Cold Temperature
  • Electric Stimulation
  • Food Handling
  • Food Quality
  • Food Storage
  • Hydrogen-Ion Concentration
  • Male
  • Meat
  • Muscle, Skeletal
  • Polysaccharides
  • Postmortem Changes
  • Time Factors

Keywords

  • Yak
  • electrical stimulation
  • postmortem aging
  • tenderness


Comparative effects of dry-aging and wet-aging on physicochemical properties and digestibility of Hanwoo beef.


Keywords

  • Beef Loin
  • Digestibility
  • Dry Aging
  • Shear Force
  • Wet Aging

MFN2

Thioredoxin protects mitochondrial structure, function and biogenesis in myocardial ischemia-reperfusion via redox-dependent activation of AKT-CREB- PGC1α pathway in aged mice.


Keywords

  • aging
  • heart
  • ischemia-reperfusion
  • mitochondria
  • thioredoxin


MFN2 contributes to metabolic disorders and inflammation in the aging of rat chondrocytes and osteoarthritis.


Keywords

  • Aging
  • Inflammation
  • MFN2
  • Metabolic disorders
  • Osteoarthritis

MFSD2A

Decreased Blood Level of MFSD2a as a Potential Biomarker of Alzheimer's Disease.


MeSH Terms

  • Aged
  • Alzheimer Disease
  • Biomarkers
  • Brain
  • Fatty Acids
  • Female
  • Humans
  • Male
  • Symporters

Keywords

  • Alzheimer’s disease
  • MFSD2a carrier
  • aging
  • neurologic disorders
  • omega-3 PUFA

MGMT

Cytotoxic and Senolytic Effects of Methadone in Combination with Temozolomide in Glioblastoma Cells.


Keywords

  • apoptosis
  • cancer therapy
  • drug resistance
  • glioblastoma
  • methadone
  • senescence
  • temozolomide

MIA

Age, cohort, and period effects on metamemory beliefs.


MeSH Terms

  • Aged
  • Aged, 80 and over
  • Aging
  • Cohort Studies
  • Cross-Sectional Studies
  • Female
  • Humans
  • Longitudinal Studies
  • Male
  • Metacognition
  • Middle Aged


Memory Age-based Stereotype Threat: Role of Locus of Control and Anxiety.


MeSH Terms

  • Aged
  • Aging
  • Anxiety
  • Female
  • Humans
  • Internal-External Control
  • Male
  • Memory, Episodic
  • Metacognition
  • Middle Aged
  • Stereotyping

MIB1

Immunohistochemical detection of senescence markers in human sarcomas.


Keywords

  • SenTraGor
  • Senescence
  • p16
  • p21
  • sarcoma

MIP

Inspiratory muscle training improves cerebrovascular and postural control responses during orthostatic stress in older women.


Keywords

  • Aging
  • Cardiac output
  • Center-of-pressure
  • Middle cerebral artery blood flow velocity
  • Respiratory muscles


A novel multi-marker discovery approach identifies new serum biomarkers for Parkinson's disease in older people: an EXosomes in PArkiNson Disease (EXPAND) ancillary study.


Keywords

  • Aging
  • Amino acids
  • Cytokines
  • Metabolomics
  • Neurodegeneration
  • Personalized medicine


Sexual dimorphism of physical activity on cognitive aging: Role of immune functioning.


Keywords

  • Brain aging
  • Chemokines
  • Cognitive aging
  • Exercise
  • Gender
  • Inflammation
  • Lifestyle


Comparison of balance changes after inspiratory muscle or Otago exercise training.


MeSH Terms

  • Aged
  • Aged, 80 and over
  • Aging
  • Breathing Exercises
  • Exercise
  • Exercise Therapy
  • Female
  • Humans
  • Male
  • Maximal Respiratory Pressures
  • Muscle Strength
  • Physical Endurance
  • Postural Balance
  • Respiratory Muscles
  • Respiratory Therapy

MITF

Thymocid , a Standardized Black Cumin ([i]Nigella sativa[/i]) Seed Extract, Modulates Collagen Cross-Linking, Collagenase and Elastase Activities, and Melanogenesis in Murine B16F10 Melanoma Cells.


Keywords

  • Nigella sativa
  • Thymocid®
  • black cumin
  • collagen
  • collagenase
  • cosmeceutical
  • elastase
  • glycation
  • melanogenesis
  • skin aging


HuRdling Senescence: HuR Breaks BRAF-Induced Senescence in Melanocytes and Supports Melanoma Growth.


Keywords

  • HuR
  • MITF
  • Microphthalmia-associated transcription factor
  • malignant melanoma
  • oncogene induced senescence

MLH1

The somatic mutation landscape of the human body.


MeSH Terms

  • Age Factors
  • Aging
  • Humans
  • Mutation
  • Neoplasms
  • Selection, Genetic
  • Sex Factors

Keywords

  • Aging
  • Cancer
  • Genomic instability
  • Human
  • Somatic evolution
  • Somatic mutation

MLKL

Remifentanil preconditioning protects against hypoxia-induced senescence and necroptosis in human cardiac myocytes [i]in vitro[/i].


Keywords

  • cardiomyocytes
  • hypoxia
  • necroptosis
  • remifentanil
  • senescence

MLN

Age-Dependent Decrease in the Induction of Regulatory T Cells Is Associated With Decreased Expression of RALDH2 in Mesenteric Lymph Node Dendritic Cells.


Keywords

  • RALDH2
  • aging
  • dendritic cells
  • epigenetic regulation
  • regulatory T cells
  • retinoic acid

MMD

Association between a Deficit Accumulation Frailty Index and Mobility Outcomes in Older Adults: Secondary Analysis of the Lifestyle Interventions and Independence for Elders (LIFE) Study.


Keywords

  • LIFE Study
  • deficit accumulation
  • disability
  • frailty
  • healthy aging
  • mobility
  • older adults


Impact of Anticholinergic Medication Burden on Mobility and Falls in the Lifestyle Interventions for Elders (LIFE) Study.


Keywords

  • anticholinergic burden
  • falls
  • mobility
  • physical activity
  • successful aging


Impact and Lessons From the Lifestyle Interventions and Independence for Elders (LIFE) Clinical Trials of Physical Activity to Prevent Mobility Disability.


Keywords

  • aging
  • mobility disability
  • multicenter trialphysical activity

MME

Geriatric Opioid Harm Reduction: Interprofessional Student Learning Outcomes.


Keywords

  • aging
  • older adults
  • opioid harm reduction
  • overdose risk


Effectiveness of local anesthetic injection in geriatric patients following operative management of proximal and diaphyseal femur fracture.


MeSH Terms

  • Aged
  • Aged, 80 and over
  • Analgesics, Opioid
  • Anesthetics, Local
  • Delirium
  • Female
  • Femoral Fractures
  • Fracture Fixation, Internal
  • Geriatrics
  • Humans
  • Injections, Intra-Articular
  • Intraoperative Care
  • Male
  • Pain Management
  • Pain, Postoperative
  • Retrospective Studies

Keywords

  • Geriatrics
  • Hip fracture
  • Local anesthetic
  • Narcotics

MMP1

Reacquisition of a spindle cell shape does not lead to the restoration of a youthful state in senescent human skin fibroblasts.


Keywords

  • Cell shape
  • Fibroblast
  • Lithography
  • SASP
  • Senescence


A novel multifunctional skin care formulation with a unique blend of antipollution, brightening and antiaging active complexes.


Keywords

  • anti-wrinkle
  • pigmentation
  • pollution
  • skin aging
  • skin barrier

MMP13

Aging aggravates intervertebral disc degeneration by regulating transcription factors toward chondrogenesis.


MeSH Terms

  • Aging
  • Animals
  • Antigens, Differentiation
  • Chondrocytes
  • Chondrogenesis
  • Core Binding Factor Alpha 1 Subunit
  • Fetal Proteins
  • Gene Expression Regulation
  • Intervertebral Disc Degeneration
  • Mice
  • Mice, Transgenic
  • Sp7 Transcription Factor
  • T-Box Domain Proteins

Keywords

  • Wnt/β-catenin/LRPs
  • biomechanics
  • genetic animal models
  • osterix

MOS

Effect of mannan oligosaccharides on the microbiota and productivity parameters of Litopenaeus vannamei shrimp under intensive cultivation in Ecuador.


MeSH Terms

  • Actinobacteria
  • Aeromonas
  • Animal Feed
  • Animals
  • Aquaculture
  • Bacterial Adhesion
  • Ecuador
  • Flavobacteriaceae
  • Lactococcus
  • Longevity
  • Mannans
  • Microbiota
  • Oligosaccharides
  • Penaeidae
  • Proteobacteria
  • Seafood
  • Shewanella
  • Verrucomicrobia
  • Vibrio


Predictors of health-related quality of life among older adults living with HIV in Thailand: results from the baseline and follow-up surveys.


Keywords

  • Chiang Mai
  • HIV and aging
  • Older adults living with HIV
  • Thailand
  • health-related quality of life
  • quality of life


Comparison of health-related quality of life between the Han and Yi ethnicity elderly in the Yi autonomous areas of Yunnan Province.


MeSH Terms

  • Activities of Daily Living
  • Aged
  • Aged, 80 and over
  • Aging
  • China
  • Cross-Sectional Studies
  • Ethnic Groups
  • Female
  • Humans
  • Male
  • Middle Aged
  • Quality of Life

Keywords

  • ADL
  • Elderly
  • Health-related quality of life
  • IADL
  • Yi ethnic minority


Mannan oligosaccharide increases the growth performance, immunity and resistance capability against Vibro Parahemolyticus in juvenile abalone Haliotis discus hannai Ino.


MeSH Terms

  • Animal Feed
  • Animals
  • Antioxidants
  • Diet
  • Dietary Supplements
  • Dose-Response Relationship, Drug
  • Gastropoda
  • Immunity, Innate
  • Longevity
  • Mannans
  • Oligosaccharides
  • Vibrio parahaemolyticus

Keywords

  • Abalone
  • Antioxidation
  • Bacterial challenge
  • Disease resistance
  • Growth
  • Immunity
  • Mannan oligosaccharide

MPHOSPH6

Genome-wide Association Analysis in Humans Links Nucleotide Metabolism to Leukocyte Telomere Length.


MeSH Terms

  • Genome-Wide Association Study
  • Humans
  • Leukocytes
  • Nucleotides
  • Telomere

Keywords

  • Mendelian randomisation
  • age-related disease
  • biological aging
  • telomere length

MPI

Age-related decline of lymphatic drainage from the eye: A noninvasive in vivo photoacoustic tomography study.


Keywords

  • Age-related
  • Aging
  • Aqueous humor
  • Drainage
  • Eye
  • Glaucoma
  • Imaging
  • In vivo
  • Lymph node
  • Lymphatic
  • Mice
  • Photoacoustic tomography
  • Uveoscleral


Interest of the multidimensional prognostic index (MPI) as an assessment tool in hospitalized patients in geriatrics.


MeSH Terms

  • Aged, 80 and over
  • Female
  • Geriatric Assessment
  • Hospital Mortality
  • Hospitalization
  • Humans
  • Length of Stay
  • Male
  • Patient Readmission
  • Prognosis

Keywords

  • elderly
  • geriatrics
  • hospitalization
  • multidimensional prognostic index

MRE11

Chromosomal alterations among age-related haematopoietic clones in Japan.


MeSH Terms

  • Aged, 80 and over
  • Aging
  • Alleles
  • Cell Lineage
  • Chromosome Aberrations
  • Chromosomes, Human
  • Clone Cells
  • Cohort Studies
  • Female
  • Genetic Loci
  • Genome, Human
  • Hematopoiesis
  • Hematopoietic Stem Cells
  • Humans
  • Japan
  • Leukemia, Lymphocytic, Chronic, B-Cell
  • Leukemia, T-Cell
  • Male
  • Mosaicism
  • Mutation
  • United Kingdom

MSC

Rejuvenation of Senescent Endothelial Progenitor Cells by Extracellular Vesicles Derived From Mesenchymal Stromal Cells.


Keywords

  • BM, bone marrow
  • CVD, cardiovascular disease
  • EC, endothelial cell
  • EPC, endothelial progenitor cell
  • EV, extracellular vesicle
  • FBS, fetal bovine serum
  • MEM, minimum essential medium
  • MI, myocardial infarction
  • MSC, mesenchymal stromal cell
  • NTA, nanotracking analysis
  • PBS, phosphate-buffered saline
  • TEV, tailored extracellular vesicle
  • VEGF, vascular endothelial growth factor
  • acellular
  • angiogenesis
  • extracellular vesicles
  • lin− BMC, lineage negative bone marrow cell
  • miR, microRNA
  • qPCR, quantitative transcription polymerase chain reaction
  • regeneration
  • senescence


Extracellular vesicles derived from bone marrow mesenchymal stem cells enhance myelin maintenance after cortical injury in aged rhesus monkeys.


Keywords

  • Aging
  • Cortical injury
  • Extracellular vesicles
  • Monkeys
  • Myelin
  • Non-human primates
  • Oligodendrocytes
  • Stroke
  • White matter


TPP1 Enhances the Therapeutic Effects of Transplanted Aged Mesenchymal Stem Cells in Infarcted Hearts via the MRE11/AKT Pathway.


Keywords

  • DNA repair
  • aging
  • myocardial infarction
  • stem cells therapy
  • telomere


Aging-Affected MSC Functions and Severity of Periodontal Tissue Destruction in a Ligature-Induced Mouse Periodontitis Model.


Keywords

  • aging
  • bone resorption
  • immunomodulation
  • mesenchymal stem cell
  • periodontitis
  • tissue destruction


Human placenta-derived mesenchymal stem cells stimulate ovarian function via miR-145 and bone morphogenetic protein signaling in aged rats.


Keywords

  • Aging
  • Follicular development
  • Hormone biosynthesis
  • Primordial follicle activation
  • Stem cell therapy
  • miR-145


Mesenchymal Stromal Cells as Critical Contributors to Tissue Regeneration.


Keywords

  • adult stem cells
  • aging
  • mesenchymal stromal cells (MSC)
  • regenerative medicine
  • stem cell niche


The biology of human hair greying.


Keywords

  • ageing
  • endocrine
  • graying
  • melanin
  • senescence


[i]Tsc1[/i] Regulates the Proliferation Capacity of Bone-Marrow Derived Mesenchymal Stem Cells.


Keywords

  • TSC1
  • mammalian target of rapamycin (mTOR)
  • mesenchymal stem cell
  • senescence
  • stem cell proliferation
  • tuberous sclerosis


The role of mitochondrial dysfunction in mesenchymal stem cell senescence.


Keywords

  • Mesenchymal stem cells
  • Mitochondrial dysfunction
  • Mitophagy
  • Reactive oxygen species
  • Senescence


Metabolic syndrome increases senescence-associated micro-RNAs in extracellular vesicles derived from swine and human mesenchymal stem/stromal cells.


Keywords

  • EV
  • MSC
  • Metabolic syndrome
  • RNA-sequencing
  • Senescence


Functional heterogeneity of mesenchymal stem cells from natural niches to culture conditions: implications for further clinical uses.


Keywords

  • Aging diseases
  • Conditioned medium
  • Diabetes
  • Exosomes
  • Extracellular vesicles
  • Lupus
  • Regenerative medicine
  • Secretome


Functional crosstalk between mTORC1/p70S6K pathway and heterochromatin organization in stress-induced senescence of MSCs.


Keywords

  • Aging
  • Heterochromatin
  • MSC senescence
  • mTORC1/p70S6K


Increased cellular senescence in the murine and human stenotic kidney: Effect of mesenchymal stem cells.


Keywords

  • cellular senescence
  • exosomes
  • kidney
  • mesenchymal stem cells
  • renal artery obstruction


Intrinsic Type 1 Interferon (IFN1) Profile of Uncultured Human Bone Marrow CD45 CD271 Multipotential Stromal Cells (BM-MSCs): The Impact of Donor Age, Culture Expansion and IFNα and IFNβ Stimulation.


Keywords

  • aging
  • bone marrow
  • mesenchymal stromal cells
  • senescence
  • type 1 interferon


Facial rejuvenation using stem cell conditioned media combined with skin needling: A split-face comparative study.


Keywords

  • amniotic fluid stem cells products
  • dermaroller
  • facial aging
  • skin needling


Mesenchymal Stem Cell Senescence and Rejuvenation: Current Status and Challenges.


Keywords

  • autophagy
  • mesenchymal stem cells
  • mitochondrial
  • rejuvenation
  • senescence
  • telomere


The changing epigenetic landscape of Mesenchymal Stem/Stromal Cells during aging.


Keywords

  • Aging
  • DNA methylation
  • Epigenetics
  • Histome modifications
  • MSC
  • Mesenchymal Stem/Stromal Cells
  • Skeleton
  • miRNA


Dual Role of Autophagy in Regulation of Mesenchymal Stem Cell Senescence.


Keywords

  • SASP
  • general autophagy
  • mesenchymal stem cell
  • selective autophagy
  • senescence


Molecular Aspects of Adipose-Derived Stromal Cell Senescence in a Long-Term Culture: A Potential Role of Inflammatory Pathways.


Keywords

  • adipose-derived stromal/stem cell
  • aging
  • gene expression
  • long-term culture
  • senescence


Human Obesity Induces Dysfunction and Early Senescence in Adipose Tissue-Derived Mesenchymal Stromal/Stem Cells.


Keywords

  • adipose tissue
  • cellular dysfunction
  • cellular senescence
  • mesenchymal stem cells
  • obesity


miR-155-5p inhibition rejuvenates aged mesenchymal stem cells and enhances cardioprotection following infarction.


Keywords

  • mesenchymal stem cells
  • miR-155-5p
  • myocardial infarction
  • rejuvenation
  • senescence


Mesenchymal Stem Cell Derived Extracellular Vesicles in Aging.


Keywords

  • aging
  • clinical translation
  • extracellular vesicles
  • mesenchymal stem cells
  • regenerative medicine
  • senescence


Molecular Mechanisms Contributing to Mesenchymal Stromal Cell Aging.


Keywords

  • MSC senescence
  • in vitro aging
  • in vivo aging
  • mesenchymal stem/stromal cells (MSC)
  • rejuvenating strategies


Inhibition of DNA Methyltransferase by RG108 Promotes Pluripotency-Related Character of Porcine Bone Marrow Mesenchymal Stem Cells.


Keywords

  • RG108
  • apoptosis
  • pluripotency
  • porcine bone marrow mesenchymal stem cells
  • senescence


Extracellular Vesicles of Stem Cells to Prevent BRONJ.


Keywords

  • bisphosphonate-associated osteonecrosis of the jaw
  • cellular senescence
  • exosomes
  • mesenchymal stem cells
  • wound healing
  • zoledronic acid


Ginsenoside Rg1 as an Effective Regulator of Mesenchymal Stem Cells.


Keywords

  • apoptosis
  • differentiation
  • ginsenoside Rg1
  • mesenchymal stem cells
  • preclinical study
  • proliferation
  • senescence


The Importance of Stem Cell Senescence in Regenerative Medicine.


Keywords

  • Aging
  • Mesenchymal stem cell
  • Regenerative medicine


Control of mesenchymal stem cell biology by histone modifications.


Keywords

  • Cell biology
  • Cell differentiation
  • Cellular senescence
  • Epigenetics
  • Histone modifications
  • Mesenchymal stem cells


Impact of mesenchymal stem cell senescence on inflammaging.


MeSH Terms

  • Aging
  • Cellular Senescence
  • Cytokines
  • Hematopoiesis
  • Humans
  • Immunomodulation
  • Immunosenescence
  • Inflammation
  • Macrophages
  • Mesenchymal Stem Cells


Late Rescue Therapy with Cord-Derived Mesenchymal Stromal Cells for Established Lung Injury in Experimental Bronchopulmonary Dysplasia.


Keywords

  • COPD
  • aging
  • lung
  • newborn
  • regenerative medicine
  • stem cells


Low-Level Radiofrequency Exposure Does Not Induce Changes in MSC Biology: An in vitro Study for the Prevention of NIR-Related Damage.


Keywords

  • 169 MHz
  • CFU
  • senescence
  • stem cell


Macrophage migration inhibitory factor rejuvenates aged human mesenchymal stem cells and improves myocardial repair.


MeSH Terms

  • Adolescent
  • Aged
  • Aged, 80 and over
  • Aging
  • Animals
  • Animals, Newborn
  • Cellular Senescence
  • Humans
  • Macrophage Migration-Inhibitory Factors
  • Mesenchymal Stem Cell Transplantation
  • Mesenchymal Stem Cells
  • Myocardial Infarction
  • Myocardium
  • Myocytes, Cardiac
  • Rats
  • Rats, Sprague-Dawley
  • Young Adult

Keywords

  • macrophage migration inhibitory factor
  • mesenchymal stem cells
  • myocardial infarction
  • rejuvenation
  • senescence


Influence of olive oil and its components on mesenchymal stem cell biology.


Keywords

  • Aging
  • Cellular differentiation
  • Cellular niche
  • Mediterranean diet
  • Mesenchymal stem cells
  • Olive oil


Epigenetic Regulation of Mesenchymal Stem Cell Homeostasis.


Keywords

  • aging
  • epigenetics
  • fate decision
  • mesenchymal stem cells
  • pathogenesis
  • regeneration


Mesenchymal Stem Cells: Allogeneic MSC May Be Immunosuppressive but Autologous MSC Are Dysfunctional in Lupus Patients.


Keywords

  • dysfunction
  • immunoregulatory
  • mesenchymal stem cells
  • senescence
  • systemic lupus erythematosus


Effects of high glucose conditions on the expansion and differentiation capabilities of mesenchymal stromal cells derived from rat endosteal niche.


MeSH Terms

  • Adipogenesis
  • Animals
  • Biomarkers
  • Bone Regeneration
  • Bone and Bones
  • Cell Differentiation
  • Cell Proliferation
  • Cells, Cultured
  • Cellular Senescence
  • Diabetes Mellitus, Type 2
  • Glucose
  • Hyperglycemia
  • Male
  • Mesenchymal Stem Cells
  • Osteogenesis
  • Rats, Wistar

Keywords

  • Bone repair
  • Cellular senescence
  • Differentiation
  • Hyperglycaemia
  • Mesenchymal stromal cells; Endosteum
  • Type II diabetes


Autophagy inhibits the mesenchymal stem cell aging induced by D-galactose through ROS/JNK/p38 signalling.


Keywords

  • ROS/JNK/p38 signalling
  • autophagy
  • mesenchymal stem cells
  • senescence


Enhancing survival, engraftment, and osteogenic potential of mesenchymal stem cells.


Keywords

  • Anoikis
  • Bioactive scaffolds
  • Bone regeneration
  • Engraftment
  • Homing
  • Hypoxia
  • Mesenchymal stem cells
  • Osteogenesis
  • Preconditioning
  • Senescence


Mesenchymal stem cell senescence alleviates their intrinsic and seno-suppressive paracrine properties contributing to osteoarthritis development.


MeSH Terms

  • Animals
  • Cell Proliferation
  • Cells, Cultured
  • Cellular Senescence
  • Chondrocytes
  • Coculture Techniques
  • Collagenases
  • Etoposide
  • Gene Expression Regulation
  • Humans
  • Inflammation
  • Luciferases
  • Male
  • Mesenchymal Stem Cells
  • Mice
  • Mice, Inbred Strains
  • Mice, Transgenic
  • Osteoarthritis
  • Paracrine Communication

Keywords

  • mesenchymal stem cell
  • osteoarthritis
  • senescence
  • tissue homeostasis


Embryonic stem cell-derived extracellular vesicles enhance the therapeutic effect of mesenchymal stem cells.


MeSH Terms

  • Animals
  • Cell- and Tissue-Based Therapy
  • Cellular Senescence
  • Disease Models, Animal
  • Embryonic Stem Cells
  • Extracellular Vesicles
  • Humans
  • Insulin-Like Growth Factor I
  • Mesenchymal Stem Cell Transplantation
  • Mesenchymal Stem Cells
  • Mice
  • Mice, Inbred BALB C
  • Phosphatidylinositol 3-Kinases
  • Wounds and Injuries

Keywords

  • Cellular senescence
  • Embryonic stem cells
  • Extracellular vesicles
  • IGF1/PI3K/AKT pathway
  • Mesenchymal stem cells


Survival of aging CD264 and CD264 populations of human bone marrow mesenchymal stem cells is independent of colony-forming efficiency.


Keywords

  • aging
  • decoy TRAIL receptor 2 (CD264)
  • mesenchymal stem cells
  • survival


Differential effects of extracellular vesicles from aging and young mesenchymal stem cells in acute lung injury.


MeSH Terms

  • Acute Lung Injury
  • Age Factors
  • Animals
  • Disease Models, Animal
  • Extracellular Vesicles
  • Mesenchymal Stem Cell Transplantation
  • Mesenchymal Stem Cells
  • Mice
  • Treatment Outcome

Keywords

  • ARDS
  • acute lung injury
  • aging
  • extracellular vesicles
  • mesenchymal stem cells


Connexin43 is Dispensable for Early Stage Human Mesenchymal Stem Cell Adipogenic Differentiation But is Protective against Cell Senescence.


MeSH Terms

  • Adipogenesis
  • Cell Differentiation
  • Cellular Senescence
  • Connexin 43
  • Gene Expression Regulation
  • Humans
  • Mesenchymal Stem Cells
  • Time Factors

Keywords

  • CRISPR-Cas9
  • adipogenesis
  • connexin43
  • gap junctional intercellular communication
  • mesenchymal stem cells
  • oculodentodigital dysplasia
  • senescence


Maintained Properties of Aged Dental Pulp Stem Cells for Superior Periodontal Tissue Regeneration.


Keywords

  • inflammation
  • mesenchymal stem cells
  • periodontitis
  • senescence

MTHFR

One-carbon metabolism supplementation improves outcome after stroke in aged male MTHFR-deficient mice.


MeSH Terms

  • Aging
  • Animals
  • Brain
  • Choline
  • Dietary Supplements
  • Male
  • Methylenetetrahydrofolate Reductase (NADPH2)
  • Mice
  • Mice, Inbred C57BL
  • Recovery of Function
  • Stroke
  • Tetrahydrofolates
  • Vitamin B 12

Keywords

  • Cerebral ischemia
  • Homocysteine
  • Methylenetetrahydrofolate reductase
  • Neurodegeneration
  • Sensorimotor cortex
  • Supplementation

MTOR

The roles of MTOR and miRNAs in endothelial cell senescence.


Keywords

  • Endothelium
  • MTOR
  • MicroRNAs
  • Senescence
  • Vascular aging


Autophagy drives fibroblast senescence through MTORC2 regulation.


Keywords

  • Autophagy
  • MTORC2
  • myofibroblast
  • rapamycin
  • senescence


The GID ubiquitin ligase complex is a regulator of AMPK activity and organismal lifespan.


Keywords

  • AMPK
  • GID
  • autophagy
  • longevity
  • primary cilium
  • ubiquitination

MTR

Amide proton transfer-weighted magnetic resonance imaging of human brain aging at 3 Tesla.


Keywords

  • Aging
  • amide proton transfer imaging
  • biomarkers
  • chemical exchange saturation transfer (CEST)
  • molecular imaging

MUC7

Reduced Salivary Mucin Binding and Glycosylation in Older Adults Influences Taste in an In Vitro Cell Model.


MeSH Terms

  • Adolescent
  • Adult
  • Aged
  • Aging
  • Cell Line
  • Epithelial Cells
  • Female
  • Glycosylation
  • Humans
  • Male
  • Middle Aged
  • Mucins
  • N-Acetylneuraminic Acid
  • Plasmids
  • Protein Binding
  • Rheology
  • Saliva
  • Taste
  • Young Adult

Keywords

  • ageing
  • mucin
  • rheology
  • saliva
  • taste

MYB

Transcriptome profiling of postharvest shoots identifies PheNAP2- and PheNAP3-promoted shoot senescence.


MeSH Terms

  • Arabidopsis
  • Arabidopsis Proteins
  • Gene Expression Profiling
  • Gene Expression Regulation, Plant
  • Plant Leaves
  • Transcriptome

Keywords

         Phyllostachys edulis
       
  • NAC
  • postharvest
  • regulatory factors
  • shoot senescence

MYC

Enhanced proliferative capacity of human preadipocytes achieved by an optimized cultivating method that induces transient activity of hTERT.


Keywords

  • Adipogenesis
  • Adipose-derived stromal cells
  • Senescence
  • hTERT
  • mTesR1

MYCN

Silencing of AURKA augments the antitumor efficacy of the AURKA inhibitor MLN8237 on neuroblastoma cells.


Keywords

  • Aurora kinase A
  • Cellular senescence
  • MLN8237
  • Neuroblastoma
  • Small interfering RNA

MYSM1

MYSM1 Suppresses Cellular Senescence and the Aging Process to Prolong Lifespan.


Keywords

  • DNA repair
  • Myb‐like, SWIRM, and MPN domains‐containing protein 1 (MYSM1)
  • aging
  • senescence
  • senescence‐associated secretory phenotype (SASP)

MYT1

ESC-sEVs Rejuvenate Aging Hippocampal NSCs by Transferring SMADs to Regulate the MYT1-Egln3-Sirt1 Axis.


Keywords

  • ESC-sEVs
  • MYT1
  • aging
  • hippocampal NSCs
  • senescence

NACA

Age and Sex Are Strongly Correlated to the Rate and Type of Mountain Injuries Requiring Search and Rescue Missions.


MeSH Terms

  • Adolescent
  • Adult
  • Aged
  • Aged, 80 and over
  • Aging
  • Emergency Medical Services
  • Female
  • Humans
  • Male
  • Middle Aged
  • Mountaineering
  • Rescue Work
  • Sex Factors
  • Young Adult

Keywords

  • MRT
  • NACA ICAR
  • SAR
  • injury
  • mechanism

NAMPT

Over-expression of Nicotinamide phosphoribosyltransferase in mouse cells confers protective effect against oxidative and ER stress-induced premature senescence.


Keywords

  • ER stress
  • NAD+
  • NAMPT
  • oxidative stress
  • premature senescence


Resistance training increases muscle NAD and NADH concentrations as well as NAMPT protein levels and global sirtuin activity in middle-aged, overweight, untrained individuals.


Keywords

  • NAD +
  • NADH
  • aging
  • muscle
  • resistance training


Differential Expression of Human N-Alpha-Acetyltransferase 40 (hNAA40), Nicotinamide Phosphoribosyltransferase (NAMPT) and Sirtuin-1 (SIRT-1) Pathway in Obesity and T2DM: Modulation by Metformin and Macronutrient Intake.


Keywords

  • NAMPT
  • T2DM
  • hNAA40
  • nicotinamide phosphoribosyltransferase
  • obesity
  • senescence
  • sirtuin-1

NDRG2

NDRG2 Expression Correlates with Neurofibrillary Tangles and Microglial Pathology in the Ageing Brain.


MeSH Terms

  • Aged
  • Aged, 80 and over
  • Aging
  • Alzheimer Disease
  • Antigens, CD
  • Antigens, Differentiation, Myelomonocytic
  • Astrocytes
  • Brain
  • DNA Damage
  • Excitatory Amino Acid Transporter 2
  • Gene Expression Regulation
  • Glial Fibrillary Acidic Protein
  • Glutamate-Ammonia Ligase
  • Humans
  • Microglia
  • Neurofibrillary Tangles
  • Tumor Suppressor Proteins
  • tau Proteins

Keywords

  • N-myc downstream regulated gene 2 (NDRG2)
  • ageing brain
  • astrocyte
  • neurofibrillary tangles

NDUFS8

Mitochondrial Complex I Mutations Predispose Drosophila to Isoflurane Neurotoxicity.


MeSH Terms

  • Aging
  • Anesthetics, Inhalation
  • Animals
  • Animals, Genetically Modified
  • Drosophila
  • Electron Transport Complex I
  • Isoflurane
  • Male
  • Mitochondria
  • Mutation
  • Sevoflurane

NEDD8

Targeting Protein Neddylation for Cancer Therapy.


MeSH Terms

  • Animals
  • Apoptosis
  • Autophagy
  • Cyclopentanes
  • Humans
  • NEDD8 Protein
  • Neoplasms
  • Pyrimidines
  • Ubiquitin-Protein Ligases
  • Ubiquitination

Keywords

  • Apoptosis
  • Autophagy
  • Cancer target
  • Inflammatory responses
  • Neddylation
  • Senescence


Effective targeting of the ubiquitin-like modifier NEDD8 for lung adenocarcinoma treatment.


Keywords

  • NEDD8
  • apoptosis
  • cullin-RING ligases
  • neddylation
  • senescence


Pevonedistat targeted therapy inhibits canine melanoma cell growth through induction of DNA re-replication and senescence.


Keywords

  • DNA re-replication
  • MLN4924
  • NAE-inhibitor
  • canine
  • melanoma
  • senescence

NEO1

Neogenin-1 distinguishes between myeloid-biased and balanced [i]Hoxb5[/i] mouse long-term hematopoietic stem cells.


MeSH Terms

  • Aging
  • Animals
  • Female
  • Hematopoietic Stem Cell Transplantation
  • Hematopoietic Stem Cells
  • Homeodomain Proteins
  • Membrane Proteins
  • Mice
  • Mice, Transgenic

Keywords

  • Neogenin-1
  • aging
  • hematopoietic stem cell
  • myeloid bias
  • transplantation

NES

Mini-review: Aging of the neuroendocrine system: Insights from nonhuman primate models.


Keywords

  • Aging
  • Neuroendocrine system
  • Nonhuman primate

NFKB1

NFKB1 gene single-nucleotide polymorphisms: implications for graft-versus-host disease in allogeneic hematopoietic stem cell transplantation.


MeSH Terms

  • Adult
  • Allografts
  • Disease-Free Survival
  • Female
  • Graft vs Host Disease
  • Hematopoietic Stem Cell Transplantation
  • Humans
  • Male
  • Middle Aged
  • NF-kappa B p50 Subunit
  • Pilot Projects
  • Polymorphism, Single Nucleotide
  • Survival Rate

Keywords

  • Allogeneic hematopoietic stem cell transplantation
  • Cellular senescence
  • Graft-versus-host disease
  • NFKB1 gene
  • Senescence-associated secretory phenotype
  • Single-nucleotide polymorphism

NGF

Dietary fish hydrolysate supplementation containing n-3 LC-PUFAs and peptides prevents short-term memory and stress response deficits in aged mice.


Keywords

  • Aging
  • Anxiety-like behaviour
  • Cognitive decline
  • Hydrolysate
  • Low molecular weight peptides
  • Marine by-products
  • Memory
  • Navigation strategies
  • Neuroinflammation
  • Stress response
  • n-3 Long chain polyunsaturated fatty acids (n-3 LC-PUFAs)


Imbalance of nerve growth factor metabolism in aging women with overactive bladder syndrome.


Keywords

  • Aging female
  • MMP-7
  • MMP-9
  • Nerve growth factor
  • Overactive bladder
  • proNGF


Parity Attenuates Intraepithelial Corneal Sensory Nerve Loss in Female Mice.


Keywords

  • aging
  • corneal epithelial cell proliferation
  • corneal sensitivity
  • corneal sensory nerves
  • mouse
  • parity
  • pregnancy


Cholinergic System and NGF Receptors: Insights from the Brain of the Short-Lived Fish [i]Nothobranchius furzeri[/i].


Keywords

  • NTRK1/NTRKA
  • aging
  • cholinergic system
  • fish
  • p75/NGFR


Retrograde axonal transport of BDNF and proNGF diminishes with age in basal forebrain cholinergic neurons.


MeSH Terms

  • Aging
  • Alzheimer Disease
  • Axonal Transport
  • Brain-Derived Neurotrophic Factor
  • Cholinergic Neurons
  • Humans
  • Nerve Growth Factor
  • Prosencephalon

Keywords

  • Alzheimer's disease
  • Axonal transport
  • Basal forebrain
  • Neurodegeneration
  • Neurotrophins
  • Trk receptors


C-SH2 point mutation converts p85β regulatory subunit of phosphoinositide 3-kinase to an anti-aging gene.


MeSH Terms

  • Aging
  • Animals
  • Blood Glucose
  • Class I Phosphatidylinositol 3-Kinases
  • Class Ia Phosphatidylinositol 3-Kinase
  • Female
  • Forkhead Transcription Factors
  • Insulin
  • Male
  • Mice
  • Mice, Inbred C57BL
  • Mice, Transgenic
  • Nerve Growth Factor
  • Oxidative Stress
  • PC12 Cells
  • Platelet-Derived Growth Factor
  • Point Mutation
  • Proto-Oncogene Proteins c-akt
  • Rats
  • src Homology Domains

NHS

Telomerase Activation to Reverse Immunosenescence in Elderly Patients With Acute Coronary Syndrome: Protocol for a Randomized Pilot Trial.


Keywords

  • acute coronary syndrome
  • coronary heart disease
  • immunosenescence
  • telomerase activator


Factors associated with COVID-19-related death using OpenSAFELY.


MeSH Terms

  • Adolescent
  • Adult
  • African Continental Ancestry Group
  • Age Distribution
  • Age Factors
  • Aged
  • Aged, 80 and over
  • Aging
  • Asian Continental Ancestry Group
  • Asthma
  • Betacoronavirus
  • COVID-19
  • Cohort Studies
  • Coronavirus Infections
  • Diabetes Mellitus
  • Female
  • Humans
  • Hypertension
  • Male
  • Middle Aged
  • Pandemics
  • Pneumonia, Viral
  • Proportional Hazards Models
  • Risk Assessment
  • SARS-CoV-2
  • Sex Characteristics
  • Smoking
  • State Medicine
  • Young Adult


Advanced ophthalmic nurse practitioners: the potential to improve outcomes for older people with cataracts.


Keywords

  • advanced practice
  • gerontology
  • older people
  • patient outcomes
  • patients
  • practice development
  • professional
  • professional issues
  • quality of life


Patient Satisfaction in the Spanish National Health Service: Partial Least Squares Structural Equation Modeling.


MeSH Terms

  • Cross-Sectional Studies
  • Gross Domestic Product
  • Health Care Rationing
  • Health Expenditures
  • Humans
  • Latent Class Analysis
  • Least-Squares Analysis
  • Life Expectancy
  • Patient Safety
  • Patient Satisfaction
  • Spain
  • State Medicine

Keywords

  • National Health Service
  • health policy
  • partial least squares structural equation modeling (PLS-SEM)
  • patient satisfaction
  • quality of healthcare


Heart failure with preserved ejection fraction (HFpEF) pathophysiology study (IDENTIFY-HF): does increased arterial stiffness associate with HFpEF, in addition to ageing and vascular effects of comorbidities? Rationale and design.


MeSH Terms

  • Aged
  • Aged, 80 and over
  • Aging
  • Biomarkers
  • Comorbidity
  • Diabetes Mellitus
  • Echocardiography
  • Exercise Tolerance
  • Female
  • Heart Failure
  • Heart Ventricles
  • Humans
  • Hypertension
  • Male
  • Observational Studies as Topic
  • Prospective Studies
  • Pulse Wave Analysis
  • Research Design
  • Stroke Volume
  • Vascular Stiffness

Keywords

  • arterial stiffness
  • comorbidities
  • heart failure with preserved ejection fraction
  • pathophysiology


Challenges to concordance: theories that explain variations in patient responses.


MeSH Terms

  • Aging
  • Benchmarking
  • Communication Barriers
  • Community Health Nursing
  • Humans
  • Nurse-Patient Relations
  • State Medicine
  • United Kingdom

Keywords

  • Concordance
  • Decision making
  • Person-centred care
  • Psychological theories
  • Self-management


Optimism is associated with exceptional longevity in 2 epidemiologic cohorts of men and women.


MeSH Terms

  • Adult
  • Aged
  • Aged, 80 and over
  • Aging
  • Female
  • Health Behavior
  • Humans
  • Logistic Models
  • Longevity
  • Longitudinal Studies
  • Male
  • Middle Aged
  • Odds Ratio

Keywords

  • aging
  • longevity
  • longitudinal study
  • optimism
  • psychological well-being

NKAP

NKAP Regulates Senescence and Cell Death Pathways in Hematopoietic Progenitors.


Keywords

  • NKAP
  • apoptosis
  • cyclin dependent kinase inhibitor
  • hematopoiesis
  • senescence

NKX6-1

The dynamic methylome of islets in health and disease.


MeSH Terms

  • Animals
  • Cell Differentiation
  • DNA Methylation
  • Diabetes Mellitus, Type 2
  • Epigenome
  • Humans
  • Insulin-Secreting Cells

Keywords

  • Aging
  • Beta cells
  • DNA methylation
  • Endocrine pancreas
  • Epigenetics

NLRC4

Hyperglycemia-induced inflamm-aging accelerates gingival senescence via NLRC4 phosphorylation.


MeSH Terms

  • Aging
  • Animals
  • Apoptosis Regulatory Proteins
  • Blotting, Western
  • Calcium-Binding Proteins
  • Cellular Senescence
  • Clustered Regularly Interspaced Short Palindromic Repeats
  • Gingiva
  • Glucose
  • Hyperglycemia
  • Immunohistochemistry
  • Inflammation
  • Interferon Regulatory Factors
  • Male
  • Mice
  • Mice, Inbred C57BL
  • RAW 264.7 Cells
  • Signal Transduction

Keywords

  • NLRC4
  • SASP
  • aging
  • cellular senescence
  • diabetes
  • gingiva
  • hyperglycemia
  • inflamm-aging
  • inflammasome
  • inflammation

NLRP12

Persistent DNA damage-induced NLRP12 improves hematopoietic stem cell function.


Keywords

  • Aging
  • DNA repair
  • Hematology
  • Hematopoietic stem cells

NLRP3

Innate and Adaptive Immunity in Aging and Longevity: The Foundation of Resilience.


Keywords

  • adaptive immunity
  • aging
  • innate immunity
  • longevity
  • resilience


TET2-Loss-of-Function-Driven Clonal Hematopoiesis Exacerbates Experimental Insulin Resistance in Aging and Obesity.


Keywords

  • CHIP
  • IL-1β
  • TET2
  • adipose tissue
  • aging
  • clonal hematopoiesis
  • diabetes
  • insulin resistance
  • obesity
  • somatic mutations


Repeated propofol exposure-induced neuronal damage and cognitive impairment in aged rats by activation of NF-κB pathway and NLRP3 inflammasome.


Keywords

  • Aging
  • Apoptosis
  • NOD-like receptor protein 3 inflammasome
  • Neuroinflammation
  • Postoperative cognitive dysfunction
  • Propofol


A Small Molecule Stabilizer of the MYC G4-Quadruplex Induces Endoplasmic Reticulum Stress, Senescence and Pyroptosis in Multiple Myeloma.


Keywords

  • ASC and pannexin 1
  • MYC G4-quadruplex stabilizer
  • NLRP3
  • caspase 1
  • endoplasmic reticulum stress
  • gasdermin D
  • inflammasome
  • pyroptosis
  • senescence


Interleukin-1β Drives Cellular Senescence of Rat Astrocytes Induced by Oligomerized Amyloid β Peptide and Oxidative Stress.


Keywords

  • Alzheimer's disease
  • amyloid β
  • astrocyte
  • interleukin-1β
  • neuroinflammation
  • senescence
  • tau


Mechanisms of NLRP3 priming in inflammaging and age related diseases.


Keywords

  • Aging
  • Inflammaging
  • Inflammasome
  • NLRP3
  • Priming
  • Senescence


Lamivudine Inhibits [i]Alu[/i] RNA-induced Retinal Pigment Epithelium Degeneration via Anti-inflammatory and Anti-senescence Activities.


Keywords

  • NLRP3 inflammasome
  • age-related macular degeneration
  • lamivudine
  • retinal pigment epithelium
  • senescence


The NLRP3 Inflammasome: Metabolic Regulation and Contribution to Inflammaging.


Keywords

  • NLRP3 inflammasome
  • aging
  • inflammation
  • metabolism
  • mitochondria


Aging aggravated liver ischemia and reperfusion injury by promoting STING-mediated NLRP3 activation in macrophages.


Keywords

  • aging
  • and reperfusion injury
  • leucine-rich repeat containing protein 3
  • liver ischemia
  • macrophage immune response
  • nucleotide-binding domain
  • stimulator of interferon genes


Targeting NLRP3 Inflammasome Reduces Age-Related Experimental Alveolar Bone Loss.


Keywords

  • aging
  • inflammasomes
  • inflammation
  • macrophages
  • osteoclasts
  • periodontitis


Korean Red Ginseng Suppresses the Expression of Oxidative Stress Response and NLRP3 Inflammasome Genes in Aged C57BL/6 Mouse Ovaries.


Keywords

  • Korean ginseng extract
  • NLRP3 inflammasome
  • aging
  • ovary
  • oxidative stress response
  • subfertility


Cepharanthine promotes the effect of dexmedetomidine on the deposition of β-amyloid in the old age of the senile dementia rat model by regulating inflammasome expression.


MeSH Terms

  • Aging
  • Animals
  • Benzylisoquinolines
  • Brain
  • Dexmedetomidine
  • Inflammasomes
  • Inflammation
  • Male
  • Mitochondria
  • Oxidative Stress
  • Rats, Sprague-Dawley
  • Reactive Oxygen Species

Keywords

  • dementia
  • dexmedetomidine
  • inflammasomes
  • β-amyloid
  • cepharanthine


Ginsenoside Rg1 ameliorates glomerular fibrosis during kidney aging by inhibiting NOX4 and NLRP3 inflammasome activation in SAMP8 mice.


Keywords

  • Ginsenoside Rg1
  • Kidney aging
  • NADPH oxidase 4 (NOX4)
  • NLRP3 inflammasome
  • Renal fibrosis


Blockade of the NLRP3 inflammasome improves metabolic health and lifespan in obese mice.


Keywords

  • Aging
  • Autophagy
  • High-fat diet
  • Longevity
  • NLRP3 inflammasome
  • Obesity


Autophagy and NLRP3 inflammasome crosstalk in neuroinflammation in aged bovine brains.


Keywords

  • NLRP3 inflammasome
  • aging
  • autophagy
  • bovine
  • immunosenescence
  • neuroinflammation


NLRP3 Inflammasome Inhibition by MCC950 in Aged Mice Improves Health via Enhanced Autophagy and PPARα Activity.


Keywords

  • Aging
  • Autophagy
  • MCC950
  • NLRP3 inflammasome
  • PPARα


NLRP3 inflammasome suppression improves longevity and prevents cardiac aging in male mice.


Keywords

  • NLRP3-inflammasome
  • autophagy
  • cardiac aging
  • longevity
  • morbidity
  • mortality


Reduced NRF2 expression suppresses endothelial progenitor cell function and induces senescence during aging.


MeSH Terms

  • Aging
  • Animals
  • Cellular Senescence
  • Endothelial Progenitor Cells
  • Mice
  • NF-E2-Related Factor 2
  • NF-kappa B
  • NLR Family, Pyrin Domain-Containing 3 Protein
  • Neovascularization, Physiologic
  • Oxidative Stress

Keywords

  • NLRP3 inflammasome
  • NRF2
  • aging
  • endothelial progenitor cells
  • oxidative stress


Effect of Aging on Taurine Transporter (TauT) Expression in the Mouse Brain Cortex.


MeSH Terms

  • Aging
  • Animals
  • Brain
  • Membrane Glycoproteins
  • Membrane Transport Proteins
  • Mice
  • Mice, Inbred C57BL
  • Taurine

Keywords

  • Age-related diseases
  • Glycine Transporter (GLYT)
  • NLRP3
  • Taurine Transporter (TauT)

NMI

Age-Dependent Control of Shoulder Muscles During a Reach-and-Lift Task.


Keywords

  • activity of daily living
  • aging
  • functional connectivity
  • motor variability
  • muscle fatigue

NMS

Uncontrolled Diabetes as an Associated Factor with Dynapenia in Adults Aged 50 Years or Older: Sex Differences.


Keywords

  • Aging
  • Dynapenia
  • Glycated hemoglobin
  • Hyperglycemia
  • Neuromuscular strength

NMUR1

[Medicinal Chemistry Focused on Mid-sized Peptides Derived from Biomolecules].


MeSH Terms

  • Aging
  • Chemistry, Pharmaceutical
  • Drug Discovery
  • Humans
  • Life Style
  • Molecular Targeted Therapy
  • Muscle Weakness
  • Muscular Atrophy
  • Myostatin
  • Neuropeptides
  • Obesity
  • Peptides
  • Receptors, Neurotransmitter
  • Structure-Activity Relationship

Keywords

  • myostatin inhibitor
  • neuromedin U receptor-selective agonist
  • peptide

NNT

Yoga, Health-Related Quality of Life and Mental Well-Being: A Re-analysis of a Meta-analysis Using the Quality Effects Model.


Keywords

  • Outcomes
  • Physical activity
  • Successful aging
  • Systematic review


Statins After Myocardial Infarction in the Oldest: A Cohort Study in the Clinical Practice Research Datalink Database.


MeSH Terms

  • Aged
  • Aged, 80 and over
  • Case-Control Studies
  • Databases, Factual
  • Female
  • Humans
  • Hydroxymethylglutaryl-CoA Reductase Inhibitors
  • Male
  • Myocardial Infarction
  • Proportional Hazards Models
  • Retrospective Studies
  • Risk Assessment
  • Secondary Prevention
  • Stroke

Keywords

  • geriatrics
  • myocardial infarction
  • secondary prevention
  • statin
  • time varying

NOP10

Pseudouridylation defect due to [i]DKC1[/i] and [i]NOP10[/i] mutations causes nephrotic syndrome with cataracts, hearing impairment, and enterocolitis.


MeSH Terms

  • Animals
  • Cataract
  • Cell Cycle Proteins
  • Child
  • Enterocolitis
  • Female
  • Genetic Predisposition to Disease
  • Hearing Loss, Sensorineural
  • Humans
  • Longevity
  • Male
  • Models, Molecular
  • Molecular Dynamics Simulation
  • Mutation
  • Nephrotic Syndrome
  • Nuclear Proteins
  • Pedigree
  • Protein Conformation
  • RNA, Ribosomal
  • Ribonucleoproteins, Small Nucleolar
  • Zebrafish

Keywords

  • H/ACA snoRNP
  • pediatrics
  • pseudouridylation
  • rRNA
  • telomere

NOS1

Prepubertal overexposure to manganese induce precocious puberty through GABA receptor/nitric oxide pathway in immature female rats.


MeSH Terms

  • Aging
  • Animals
  • Chlorides
  • Endocrine Disruptors
  • Female
  • Gonadotropin-Releasing Hormone
  • Manganese Compounds
  • Neurons
  • Nitric Oxide
  • Ovary
  • Preoptic Area
  • Rats
  • Rats, Sprague-Dawley
  • Receptors, GABA-A
  • Sexual Maturation
  • Signal Transduction
  • Uterus
  • Weaning

Keywords

  • GABA(A)R
  • GnRH
  • Manganese
  • Nitric oxide
  • Precocious puberty

NOS3

Application of Oxidative Stress to a Tissue-Engineered Vascular Aging Model Induces Endothelial Cell Senescence and Activation.


Keywords

  • endothelial cells
  • oxidative stress
  • senescence
  • tissue-engineered blood vessel
  • vascular smooth muscle cells

NOTCH1

[How Does Aging Contribute to Cancer?]


MeSH Terms

  • Aged
  • Aging
  • Carcinogenesis
  • Esophageal Neoplasms
  • Humans
  • Mutation


H19 is not hypomethylated or upregulated with age or sex in the aortic valves of mice.


MeSH Terms

  • Aging
  • Animals
  • Aortic Valve
  • Aortic Valve Stenosis
  • Calcinosis
  • DNA Methylation
  • Female
  • Male
  • Mice
  • Mice, Inbred C57BL
  • RNA, Long Noncoding
  • Sex Factors
  • Up-Regulation

Keywords

H19

  • age
  • calcific aortic valve disease
  • epigenetics

NOTCH4

Age-dependent autophagy induction after injury promotes axon regeneration by limiting NOTCH.


Keywords

  • Aging
  • DLK
  • LC3
  • Notch signaling
  • autophagy
  • axon injury
  • axon regeneration

NOX4

Sestrin2 Attenuates Cellular Senescence by Inhibiting NADPH Oxidase 4 Expression.


Keywords

  • NOX4
  • Reactive oxygen species
  • Senescence
  • Sestrin2

NPM1

Flow cytometric identification and cell-line establishment of macrophages in naked mole-rats.


MeSH Terms

  • Animals
  • Cell Line
  • Cell Proliferation
  • Cell Separation
  • Culture Media
  • Flow Cytometry
  • Longevity
  • Macrophage Colony-Stimulating Factor
  • Macrophages
  • Mole Rats
  • Recombinant Proteins

NPR1

The NPR1-WRKY46-WRKY6 signaling cascade mediates probenazole/salicylic acid-elicited leaf senescence in Arabidopsis thaliana.


Keywords

  • Leaf senescence
  • NPR1
  • Probenazole
  • Salicylic acid
  • WRKY46
  • WRKY6


Loss of proton/calcium exchange 1 results in the activation of plant defense and accelerated senescence in Arabidopsis.


Keywords

  • Early senescence
  • H(+)/Ca(2+)exchanger 1
  • Plant defense
  • Salicylic acid
  • Scopoletin

NPW

Novel information processing at work across time is associated with cognitive change in later life: A 14-year longitudinal study.


MeSH Terms

  • Aged
  • Aging
  • Cognition
  • Cognitive Aging
  • Cognitive Dysfunction
  • Employment
  • Female
  • Humans
  • Longitudinal Studies
  • Male
  • Middle Aged
  • Retirement
  • Time

NPY

Neuropeptide Y Enhances Progerin Clearance and Ameliorates the Senescent Phenotype of Human Hutchinson-Gilford Progeria Syndrome Cells.


Keywords

  • Autophagy
  • Caloric restriction mimetic
  • Cellular senescence
  • Human aging


Effects of rikkunshito supplementation on resistance to oxidative stress and lifespan in mice.


MeSH Terms

  • Animals
  • Caloric Restriction
  • Dietary Supplements
  • Drugs, Chinese Herbal
  • Female
  • Ghrelin
  • Longevity
  • Male
  • Mice
  • Mice, Knockout
  • Oxidative Stress

Keywords

  • calorie restriction
  • ghrelin
  • longevity
  • metabolism
  • oxidative stress

NRAS

Senescent cholangiocytes release extracellular vesicles that alter target cell phenotype via the epidermal growth factor receptor.


Keywords

  • biliary epithelial cell
  • cellular senescence
  • extracellular vesicles
  • primary sclerosing cholangitis
  • senescence-associated secretory phenotype


STAT3 Relays a Differential Response to Melanoma-Associated [i]NRAS[/i] Mutations.


Keywords

  • NRAS
  • STAT3
  • melanoma
  • mutation
  • oncogene-induced senescence


Cooperation of Dnmt3a R878H with Nras G12D promotes leukemogenesis in knock-in mice: a pilot study.


MeSH Terms

  • Animals
  • Apoptosis
  • Carcinogenesis
  • Cell Differentiation
  • DNA (Cytosine-5-)-Methyltransferases
  • Disease Models, Animal
  • Disease Progression
  • Gene Expression Regulation, Neoplastic
  • Gene Knock-In Techniques
  • Leukemia, Myeloid, Acute
  • Longevity
  • Mice
  • Mice, Inbred C57BL
  • Mice, Transgenic
  • Monomeric GTP-Binding Proteins
  • Mutation
  • Phenotype
  • Pilot Projects
  • Proto-Oncogene Proteins c-myc
  • RNA-Seq
  • Transcription, Genetic

Keywords

  • Acute myeloid leukemia
  • DNMT3A mutation
  • Myc activation
  • Nras G12D

NRL

Development of a cyclophosphamide stress test to predict resilience to aging in mice.


Keywords

  • Aging mice
  • Cyclophosphamide
  • Neutrophil lymphocyte ratio
  • Resilience to aging
  • Stress test
  • WBC count

NRM

Association between Clonal Hematopoiesis and Late Nonrelapse Mortality after Autologous Hematopoietic Cell Transplantation.


MeSH Terms

  • Adult
  • Age Factors
  • Aged
  • Aging
  • Autografts
  • Female
  • Hematopoiesis
  • Hematopoietic Stem Cell Transplantation
  • Humans
  • Lymphoma, Non-Hodgkin
  • Male
  • Middle Aged
  • Multiple Myeloma
  • Retrospective Studies

Keywords

  • Autologous
  • Clonal hematopoiesis
  • Lymphoma
  • Multiple myeloma
  • Nonrelapse mortality
  • Survivors
  • Transplantation

NSF

Effects of air pollution on children from a socioecological perspective.


MeSH Terms

  • Air Pollution
  • Child Mortality
  • Child, Preschool
  • Environment
  • Humans
  • Income
  • Infant
  • Life Expectancy
  • Retrospective Studies
  • Socioeconomic Factors
  • Sociological Factors

Keywords

  • Deaths of children under age 5
  • Electrification rates
  • Income
  • Inequality in life expectancy
  • Natural resource depletion
  • Non-solid fuel
  • Outdoor and indoor air pollution
  • Socioecological perspective

NT5E

The NT5E gene variant strongly affects the degradation rate of inosine 5'-monophosphate under postmortem conditions in Japanese Black beef.


MeSH Terms

  • 5'-Nucleotidase
  • Animals
  • Cattle
  • Diaphragm
  • Food Handling
  • Inosine Monophosphate
  • Muscle, Skeletal
  • Polymorphism, Single Nucleotide
  • Postmortem Changes
  • Red Meat
  • Taste

Keywords

  • Inosine 5′-monophosphate
  • Japanese Black beef
  • Meat quality
  • NT5E
  • Postmortem aging

NTHL1

Mitochondrial base excision repair positively correlates with longevity in the liver and heart of mammals.


Keywords

  • AP endonuclease
  • Aging
  • DNA glycosylases
  • DNA repair
  • Mitochondria

NUCB2

Ontogenetic Pattern Changes of Nucleobindin-2/Nesfatin-1 in the Brain and Intestinal Bulb of the Short Lived African Turquoise Killifish.


Keywords

  • Nesf-1
  • Nothobranchius furzeri
  • aging
  • brain-gut axis
  • vertebrate

OGA

NPGPx-Mediated Adaptation to Oxidative Stress Protects Motor Neurons from Degeneration in Aging by Directly Modulating O-GlcNAcase.


MeSH Terms

  • Aging
  • Amyotrophic Lateral Sclerosis
  • Animals
  • Female
  • Humans
  • Mice
  • Mice, Mutant Strains
  • Motor Neurons
  • Muscle Denervation
  • Oxidative Stress
  • Paralysis
  • beta-N-Acetylhexosaminidases

Keywords

  • ALS
  • NPGPx
  • O-GlcNAcylation
  • OGA
  • aging
  • motor neuron
  • oxidative stress

OGG1

Advanced Age Is Associated with Iron Dyshomeostasis and Mitochondrial DNA Damage in Human Skeletal Muscle.


MeSH Terms

  • Adult
  • Aged
  • Aged, 80 and over
  • Aging
  • DNA, Mitochondrial
  • Female
  • Homeostasis
  • Humans
  • Inflammation
  • Iron
  • Male
  • Mitochondria, Muscle
  • Quadriceps Muscle
  • Young Adult

Keywords

  • ZIP
  • ferritin
  • hepcidin
  • inflammation
  • iron overload
  • mitochondrial dysfunction
  • mtDNA
  • muscle aging
  • physical performance
  • transferrin

OGT

ELT-2 promotes O-GlcNAc transferase OGT-1 expression to modulate Caenorhabditis elegans lifespan.


Keywords

  • Caenorhabditis elegans
  • GATA factor ELT-2
  • OGT-1
  • lifespan


Neuronal O-GlcNAcylation Improves Cognitive Function in the Aged Mouse Brain.


MeSH Terms

  • Acetylglucosamine
  • Acylation
  • Aging
  • Animals
  • Cognition
  • Male
  • Mice
  • Mice, Knockout
  • N-Acetylglucosaminyltransferases

Keywords

  • O-GlcNAcylation
  • OGT
  • aging
  • brain
  • cognition
  • hippocampus
  • rejuvenation
  • synaptic plasticity

OSM

Age Differences in Sexual Minority Stress and the Importance of Friendship in Later Life.


Keywords

  • LGBT
  • Sexual minorities
  • cohort differences
  • discrimination
  • friendship aging
  • internalized homonegativity
  • minority stress
  • outness
  • social support

OTC

Age and growth of stocked juvenile Shoal Bass in a tailwater: Environmental variation and accuracy of daily age estimates.


MeSH Terms

  • Aging
  • Animals
  • Bass
  • Ecosystem
  • Environmental Monitoring
  • Population Dynamics
  • Reproduction
  • Rivers

P2RY12

Potential caveats of putative microglia-specific markers for assessment of age-related cerebrovascular neuroinflammation.


Keywords

  • Aging
  • Brain infiltrating myeloid cells
  • CD45
  • Cerebral amyloid angiopathy
  • Microglia
  • Neuroinflammation
  • P2RY12
  • Stroke
  • Tmem119


Microglial changes in the early aging stage in a healthy retina and an experimental glaucoma model.


Keywords

  • Aging
  • CD68
  • Glaucoma
  • Iba-1
  • Inflammation
  • MHCII
  • Microglia
  • Mouse
  • Ocular hypertension
  • P2RY12
  • Retina


Patterns of Expression of Purinergic Receptor P2RY12, a Putative Marker for Non-Activated Microglia, in Aged and Alzheimer's Disease Brains.


MeSH Terms

  • Aging
  • Alzheimer Disease
  • Biomarkers
  • Brain
  • Humans
  • Immunohistochemistry
  • Inflammation
  • Macrophages
  • Microglia
  • Phenotype
  • Plaque, Amyloid
  • Receptors, Purinergic P2Y2

Keywords

  • Alzheimer’s disease
  • activation phenotypes
  • amyloid
  • immunohistochemistry
  • microglia
  • neuroinflammation
  • temporal cortex

P4HA2

Expanding the Phenotypic and Genotypic Landscape of Nonsyndromic High Myopia: A Cross-Sectional Study in 731 Chinese Patients.


MeSH Terms

  • Adolescent
  • Adult
  • Aged
  • Aged, 80 and over
  • Aging
  • Asian Continental Ancestry Group
  • Axial Length, Eye
  • Child
  • Child, Preschool
  • China
  • Cross-Sectional Studies
  • DNA Mutational Analysis
  • Female
  • Genetic Association Studies
  • Genotype
  • Humans
  • Male
  • Middle Aged
  • Myopia, Degenerative
  • Phenotype
  • Retinal Diseases
  • Vision, Low
  • Young Adult

P4HA3

Age-associated genes in human mammary gland drive human breast cancer progression.


MeSH Terms

  • Adult
  • Age Factors
  • Aged
  • Aged, 80 and over
  • Animals
  • Biomarkers, Tumor
  • Breast
  • Breast Neoplasms
  • Disease Progression
  • Dyneins
  • Female
  • Gene Expression Regulation, Neoplastic
  • Heterografts
  • Humans
  • Mice
  • Mice, Inbred NOD
  • Mice, SCID
  • Middle Aged
  • Procollagen-Proline Dioxygenase
  • Prognosis
  • Survival Rate
  • Tumor Cells, Cultured

Keywords

  • ALX4
  • Aging
  • Breast cancer
  • DYNLT3
  • Gene expression
  • P4HA3
  • Relapse-free survival
  • Transcriptomics
  • Tumor progression

PAH

Changes in light absorption by brown carbon in soot particles due to heterogeneous ozone aging in a smog chamber.


MeSH Terms

  • Aerosols
  • Biomass
  • Carbon
  • Ozone
  • Smog
  • Soot

Keywords

  • Absorption Ångström exponent
  • Brown carbon
  • Light absorption
  • Ozone aging
  • Soot particles


Factors associated with pulmonary arterial hypertension (PAH) in systemic sclerosis (SSc).


MeSH Terms

  • Aging
  • Humans
  • Natriuretic Peptide, Brain
  • Pulmonary Arterial Hypertension
  • Risk Factors
  • Scleroderma, Systemic


Potentially Avoidable Hospitalization among Long-Term Care Insurance Beneficiaries with Dementia.


Keywords

  • Aging
  • Dementia
  • Long-Term Care

PAM

Relationship between patient activation measurement and self-rated health in patients with chronic diseases.


Keywords

  • Aging population
  • Chronic diseases
  • Patient activation measurement
  • Primary health care
  • Self-rated health


Reversal of Age-Related Neuronal Atrophy by α5-GABAA Receptor Positive Allosteric Modulation.


Keywords

  • GABA
  • aging
  • cognition
  • neurotrophic effect
  • positive allosteric modulator


The ratio of prematurely aging to non-prematurely aging mice cohabiting, conditions their behavior, immunity and lifespan.


MeSH Terms

  • Aging
  • Aging, Premature
  • Animals
  • Behavior, Animal
  • Female
  • Housing, Animal
  • Longevity
  • Lymphocytes
  • Macrophages
  • Mice
  • Oxidative Stress
  • Social Environment

Keywords

  • Behavior
  • Immunity
  • Mean lifespan
  • Prematurely aging mice
  • Social environmental strategy

PAX8

Inadequate control of thyroid hormones sensitizes to hepatocarcinogenesis and unhealthy aging.


MeSH Terms

  • Aging
  • Animals
  • Fatty Liver
  • Insulin Resistance
  • Liver
  • Liver Neoplasms
  • Male
  • Mice
  • Mice, Knockout
  • PAX8 Transcription Factor
  • Thyroid Hormones

Keywords

  • glucose metabolism
  • healthspan
  • hyperthyroidism
  • hypothyroidism
  • lifespan
  • thyroid hormones

PBX1

Internalization of the TAT-PBX1 fusion protein significantly enhances the proliferation of human hair follicle-derived mesenchymal stem cells and delays their senescence.


Keywords

  • AKT
  • Hair follicle mesenchymal stem cells
  • PBX1
  • Protein purification
  • Senescence
  • TAT

PC

Blended home-based exercise and dietary protein in community-dwelling older adults: a cluster randomized controlled trial.


Keywords

  • Aging
  • Behaviour change
  • Physical functioning
  • Protein
  • Sarcopenia
  • e-Health


Right ventricular diastolic function in aging: a head-to-head comparison between phase-contrast MRI and Doppler echocardiography.


Keywords

  • Aging
  • Diastolic function
  • Phase-contrast MRI
  • Right ventricle


Pulse Width and Implantable Pulse Generator Longevity in Pallidal Deep Brain Stimulation for Dystonia: A Population-Based Comparative Effectiveness Study.


Keywords

  • Deep brain stimulation
  • Dystonia
  • Globus pallidus internus
  • Pulse generator longevity
  • Pulse width


Gemcitabine plus nab-paclitaxel with initial dose reduction for older patients with advanced pancreatic cancer.


Keywords

  • Adverse events
  • Chemotherapy
  • Gemcitabine
  • Geriatrics
  • Nab-paclitaxel
  • Pancreatic cancer


Protective effects of 17-β-oestradiol and phytoestrogen on age-induced oxidative stress and inhibition of surfactant synthesis in rat type II pneumocytes.


Keywords

  • 17-β-Oestradiol
  • aging
  • oxidative stress
  • phytoestrogen
  • surfactant
  • type ii pneumocytes


Pacing During 200-m Competitive Masters Swimming.


MeSH Terms

  • Adult
  • Age Factors
  • Aged
  • Aged, 80 and over
  • Aging
  • Athletes
  • Athletic Performance
  • Competitive Behavior
  • Female
  • Humans
  • Male
  • Middle Aged
  • Sex Factors
  • Swimming


Prostate cancer in Pennsylvania: The role of older age at diagnosis, aggressiveness, and environmental risk factors on treatment and mortality using data from the Pennsylvania Cancer Registry.


Keywords

  • aging
  • behavioral risk factors
  • geriatric oncology
  • healthy aging
  • prostate cancer survivorship


Extracranial versus intracranial hydro-hemodynamics during aging: a PC-MRI pilot cross-sectional study.


MeSH Terms

  • Aged
  • Aged, 80 and over
  • Brain
  • Cerebral Ventricles
  • Cerebrospinal Fluid
  • Cerebrovascular Circulation
  • Cross-Sectional Studies
  • Female
  • Hemodynamics
  • Humans
  • Magnetic Resonance Imaging
  • Male
  • Middle Aged

Keywords

  • Aging
  • Arterial cerebral blood flow
  • CSF flow
  • PC-MRI
  • Pulsatility
  • Venous cerebral blood flow


Age-specific health-related quality of life in disease-free long-term prostate cancer survivors versus male population controls-results from a population-based study.


MeSH Terms

  • Adult
  • Age Factors
  • Aged
  • Aging
  • Cancer Survivors
  • Case-Control Studies
  • Disease-Free Survival
  • Germany
  • Humans
  • Male
  • Middle Aged
  • Prostatic Neoplasms
  • Quality of Life
  • Surveys and Questionnaires
  • Young Adult

Keywords

  • Health-related quality of life
  • Long-term survivor
  • Population-based
  • Prostate cancer


Cross-Linked Polyphenol-Based Drug Nano-Self-Assemblies Engineered to Blockade Prostate Cancer Senescence.


MeSH Terms

  • Animals
  • Antineoplastic Agents
  • Apoptosis
  • Cell Line, Tumor
  • Cellular Senescence
  • Docetaxel
  • Forkhead Box Protein O1
  • Humans
  • Male
  • Mice
  • Mice, Nude
  • Nanostructures
  • Polyphenols
  • Prostatic Neoplasms
  • Receptor, Transforming Growth Factor-beta Type I
  • Signal Transduction
  • Tannins
  • Transplantation, Heterologous

Keywords

  • DSAs
  • apoptosis
  • docetaxel
  • nanoassemblies
  • prostate cancer
  • senescence


An Immersive Virtual Reality Platform for Assessing Spatial Navigation Memory in Predementia Screening: Feasibility and Usability Study.


Keywords

  • cognition
  • dementia
  • healthy aging
  • memory
  • virtual reality

PCNA

Impairment of Pol β-related DNA Base-excision Repair Leads to Ovarian Aging in Mice.


Keywords

  • BER
  • Pol β
  • menopause
  • oocytes
  • ovarian aging


[Heat shock protein 90 (HSP90) in age-dependent changes in the number of fibroblasts in human skin.]


MeSH Terms

  • Adolescent
  • Adult
  • Aging
  • Child
  • Child, Preschool
  • Dermis
  • Female
  • Fibroblasts
  • HSP90 Heat-Shock Proteins
  • Humans
  • Infant
  • Infant, Newborn
  • Middle Aged
  • Pregnancy
  • Young Adult

Keywords

  • HSP90
  • PCNA
  • aging
  • fibroblasts
  • skin


A Higher Frequency Administration of the Nontoxic Cycloartane-Type Triterpene Argentatin A Improved Its Anti-Tumor Activity.


Keywords

  • Argentatin A
  • PCNA
  • antiproliferative
  • antitumor
  • apoptosis
  • cell senescence
  • colon cancer
  • xenografts


[Mechanosensitive protein of Hippo regulatory pathway - transcription coactivator with PZD-binding motif (TAZ) in human skin during aging.]


MeSH Terms

  • Adolescent
  • Adult
  • Aged
  • Aged, 80 and over
  • Aging
  • Child
  • Child, Preschool
  • Dermis
  • Female
  • Fibroblasts
  • Humans
  • Infant
  • Infant, Newborn
  • Middle Aged
  • Pregnancy
  • Protein-Serine-Threonine Kinases
  • Skin Aging
  • Trans-Activators
  • Young Adult

Keywords

  • CD31
  • PCNA
  • TAZ
  • aging
  • blood vessels
  • fibroblasts
  • skin


[Mechanosensitive Yes-associated protein in human skin during aging.]


MeSH Terms

  • Adaptor Proteins, Signal Transducing
  • Adult
  • Aged
  • Aged, 80 and over
  • Aging
  • Dermis
  • Endothelial Cells
  • Female
  • Fibroblasts
  • Humans
  • Middle Aged
  • Pregnancy
  • Skin Aging
  • Transcription Factors

Keywords

  • CD31
  • PCNA
  • YAP
  • aging
  • blood vessels
  • fibroblasts
  • skin


[Role of mechanosensitive protein Piezo1 in human age-dependent changes in the number of fibroblasts and blood vessels in human skin.]


MeSH Terms

  • Adolescent
  • Adult
  • Aged
  • Aged, 80 and over
  • Blood Vessels
  • Child
  • Child, Preschool
  • Dermis
  • Female
  • Fibroblasts
  • Humans
  • Infant
  • Ion Channels
  • Male
  • Middle Aged
  • Platelet Endothelial Cell Adhesion Molecule-1
  • Pregnancy
  • Proliferating Cell Nuclear Antigen
  • Skin Aging

Keywords

  • CD31
  • PCNA
  • Piezo1
  • aging
  • blood vessels
  • fibroblasts
  • skin

PCSK9

Lipoprotein removal mechanisms and aging: implications for the cardiovascular health of the elderly.


MeSH Terms

  • Aged
  • Aged, 80 and over
  • Aging
  • Apolipoproteins B
  • Atherosclerosis
  • Cardiovascular Diseases
  • Cardiovascular System
  • Cholesterol
  • Humans
  • Lipid Metabolism
  • Lipoproteins
  • Lipoproteins, LDL
  • Risk Factors


The role of proprotein convertase subtilisin-kexin type 9 (PCSK9) in the vascular aging process - is there a link?


Keywords

  • PCSK9
  • atherosclerosis
  • cholesterol
  • inflammation
  • vascular aging

PDCD4

Petal abscission in roses is associated with the activation of a truncated version of the animal PDCD4 homologue, RbPCD1.


MeSH Terms

  • Amino Acid Sequence
  • Arabidopsis
  • Gene Expression Regulation, Plant
  • Plant Proteins
  • Plants, Genetically Modified
  • Programmed Cell Death 1 Receptor
  • Rosa
  • Sequence Alignment
  • Transcription Factors

Keywords

  • Ethylene
  • Heat shock
  • Inflorescence
  • MA3 domain
  • PDCD4
  • Repression
  • Senescence

PDE2A

TAK-915, a phosphodiesterase 2A inhibitor, ameliorates the cognitive impairment associated with aging in rodent models.


MeSH Terms

  • Aging
  • Animals
  • Brain
  • Cognition
  • Cognition Disorders
  • Cognitive Dysfunction
  • Cyclic AMP
  • Cyclic GMP
  • Cyclic Nucleotide Phosphodiesterases, Type 2
  • Male
  • Memory Disorders
  • Memory, Episodic
  • Phosphodiesterase Inhibitors
  • Pyrazines
  • Pyridines
  • Rats
  • Rats, Inbred F344
  • Rats, Long-Evans
  • Rats, Sprague-Dawley

Keywords

  • Aging
  • Cognition
  • PDE2A
  • TAK-915

PDE4D

Phosphodiesterase PDE4D Is Decreased in Frontal Cortex of Aged Rats and Positively Correlated With Working Memory Performance and Inversely Correlated With PKA Phosphorylation of Tau.


Keywords

  • Alzheimer’s disease
  • PDE4D
  • aging
  • tau
  • working memory

PDE5A

Repurposing erectile dysfunction drugs tadalafil and vardenafil to increase bone mass.


MeSH Terms

  • Aging
  • Animals
  • Bone Density
  • Bone and Bones
  • Brain
  • Cell Differentiation
  • Cyclic Nucleotide Phosphodiesterases, Type 5
  • Drug Repositioning
  • Erectile Dysfunction
  • Humans
  • Male
  • Mice
  • Middle Aged
  • Models, Animal
  • Models, Molecular
  • Neurons
  • Osteoblasts
  • Osteoclasts
  • Osteogenesis
  • Osteoporosis
  • Osteoporotic Fractures
  • Phosphodiesterase 5 Inhibitors
  • Primary Cell Culture
  • Tadalafil
  • Vardenafil Dihydrochloride

Keywords

  • PDE5 inhibitor
  • computational modeling
  • cyclic GMP
  • osteoporosis
  • resorption

PDK1

Inhibition of 3-phosphoinositide-dependent protein kinase 1 (PDK1) can revert cellular senescence in human dermal fibroblasts.


Keywords

  • PDK1
  • cellular senescence
  • network modeling
  • skin aging
  • systems biology


The Impact of the PI3K/Akt Signaling Pathway in Anxiety and Working Memory in Young and Middle-Aged PDK1 K465E Knock-In Mice.


Keywords

  • PI3K/Akt
  • RDoC
  • aging
  • animal model
  • anxiety
  • cognition
  • fine tuning
  • signaling pathway

PER1

Quercetin, caffeic acid and resveratrol regulate circadian clock genes and aging-related genes in young and old human lung fibroblast cells.


MeSH Terms

  • ARNTL Transcription Factors
  • Age Factors
  • Aging
  • CLOCK Proteins
  • Caffeic Acids
  • Cell Line
  • Circadian Clocks
  • Circadian Rhythm
  • Fibroblasts
  • Humans
  • NF-E2-Related Factor 2
  • Polyphenols
  • Quercetin
  • Receptors, Glucocorticoid
  • Resveratrol
  • Sirtuin 1

Keywords

  • Caffeic acid
  • Circadian clock genes
  • NR1D1
  • NRF2
  • Quercetin
  • Resveratrol

PER2

NAD Controls Circadian Reprogramming through PER2 Nuclear Translocation to Counter Aging.


MeSH Terms

  • ARNTL Transcription Factors
  • Age Factors
  • Aging
  • Animals
  • CLOCK Proteins
  • Circadian Clocks
  • Circadian Rhythm
  • Cytokines
  • Female
  • HEK293 Cells
  • Humans
  • Male
  • Mice
  • Mice, Inbred C57BL
  • NAD
  • Period Circadian Proteins
  • Sirtuin 1
  • Sirtuins

Keywords

  • NAD(+)
  • SIRT1
  • aging
  • circadian
  • clock
  • heat shock factor 1
  • liver
  • nicotinamide mononucleotide
  • nicotinamide riboside
  • transcriptomics

PEX19

A genome-wide screen identifies genes that suppress the accumulation of spontaneous mutations in young and aged yeast cells.


MeSH Terms

  • Amino Acid Transport Systems, Basic
  • Cellular Senescence
  • DNA Replication
  • Flap Endonucleases
  • Gene Ontology
  • Genetic Techniques
  • Genomic Instability
  • Membrane Proteins
  • Mutagenesis
  • Mutation
  • Mutation Accumulation
  • Mutation Rate
  • Nuclear Pore Complex Proteins
  • Saccharomyces cerevisiae
  • Saccharomyces cerevisiae Proteins
  • Single-Strand Specific DNA and RNA Endonucleases

Keywords

  • genome stability
  • high-throughput screen
  • mutagenesis
  • mutation rate
  • replicative aging
  • yeast

PEX5

Aging lowers PEX5 levels in cortical neurons in male and female mouse brains.


Keywords

  • Aging brain
  • PEX5
  • Peroxisomal protein

PFAS

Associations between serum concentrations of perfluoroalkyl substances and DNA methylation in women exposed through drinking water: A pilot study in Ronneby, Sweden.


Keywords

  • EPIC chip
  • Environmental pollutant
  • Epigenetic aging
  • Epigenetics
  • PFAS
  • Perfluoroalkyl substance


Perfluorinated alkyl substances impede growth, reproduction, lipid metabolism and lifespan in Daphnia magna.


MeSH Terms

  • Alkanesulfonic Acids
  • Animals
  • Caprylates
  • Daphnia
  • Fatty Acids
  • Fluorocarbons
  • Humans
  • Lipid Metabolism
  • Longevity
  • Reproduction

Keywords

  • Fatty acid
  • Fecundity
  • Gene expression
  • PFAS toxicity
  • Perfluorooctane sulfonate (PFOS)
  • Perfluorooctanoic acid (PFOA)


The effect of weathering on per- and polyfluoroalkyl substances (PFASs) from durable water repellent (DWR) clothing.


MeSH Terms

  • Acrylates
  • Alcohols
  • Clothing
  • Environmental Monitoring
  • Fluorocarbon Polymers
  • Fluorocarbons
  • Humidity
  • Models, Chemical
  • Textiles
  • Water
  • Water Pollutants, Chemical
  • Weather

Keywords

  • Aging
  • Durable water repellency
  • Outdoor clothing
  • Per- and polyfluoroalkyl substances
  • Textile
  • Weathering

PGC

The Aging Stress Response and Its Implication for AMD Pathogenesis.


Keywords

  • AMD
  • DNA damage response
  • PGC-1α
  • SIRT1
  • age-related macular degeneration
  • aging
  • autophagy
  • insulin/IGF-1
  • mitochondrial quality control
  • the aging stress response


Constitutive PGC-1α Overexpression in Skeletal Muscle Does Not Contribute to Exercise-Induced Neurogenesis.


Keywords

  • Aging
  • Hippocampal neurogenesis
  • Immunohistochemistry
  • PGC-1α
  • Transgenic mice
  • Voluntary running


Dysregulated Autophagy Mediates Sarcopenic Obesity and Its Complications via AMPK and PGC1α Signaling Pathways: Potential Involvement of Gut Dysbiosis as a Pathological Link.


Keywords

  • AMPK signaling pathway
  • PGC-1α signaling pathway
  • aging
  • autophagy
  • gut axis
  • inflammation
  • insulin resistance
  • sarcopenic obesity


Resemblance and differences in dietary restriction nephroprotective mechanisms in young and old rats.


Keywords

  • aging
  • caloric restriction
  • ischemia/reperfusion
  • kidney injury
  • mitochondria


Acute and chronic effects of resistance training on skeletal muscle markers of mitochondrial remodeling in older adults.


Keywords

  • aging
  • mitochondrial dynamics
  • mitochondrial function


PGC-1α-mediated regulation of mitochondrial function and physiological implications.


Keywords

  • aging
  • exercise metabolism
  • insulin resistance
  • mitochondrial metabolism
  • muscle metabolism
  • muscle physiology
  • métabolisme mitochondrial
  • métabolisme musculaire
  • métabolisme à l’effort
  • physiologie musculaire
  • résistance à l’insuline
  • vieillissement


Targeting Mitochondrial Network Architecture in Down Syndrome and Aging.


Keywords

  • Down syndrome
  • PGC-1α/PPARGC1A
  • aging
  • mTOR
  • mitochondrial dynamics
  • mitochondrial function
  • mitochondrial network


Colchicine treatment impairs skeletal muscle mitochondrial function and insulin sensitivity in an age-specific manner.


Keywords

  • ADP sensitivity
  • ROS
  • aging
  • autophagy


A novel dipeptide from potato protein hydrolysate augments the effects of exercise training against high-fat diet-induced damages in senescence-accelerated mouse-prone 8 by boosting pAMPK / SIRT1/ PGC-1α/ pFOXO3 pathway.


Keywords

  • alcalase
  • bioactive peptides
  • cardio-protection
  • hepato-protection
  • longevity


Mitochondrial nucleoid remodeling and biogenesis are regulated by the p53-p21 -PKCζ pathway in p16 -silenced cells.


Keywords

  • mitochondria
  • nucleoid remodeling
  • p16INK4a silence
  • p53-p21-PKCζ activation
  • senescence


[Metabolic Alteration in Aging Process: Metabolic Remodeling in White Adipose Tissue by Caloric Restriction].


MeSH Terms

  • Adipose Tissue, White
  • Aging
  • Animals
  • Caloric Restriction
  • Gene Expression
  • Humans
  • Longevity
  • Mice
  • Organelle Biogenesis
  • Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha
  • Sirtuin 3
  • Sterol Regulatory Element Binding Protein 1
  • Up-Regulation

Keywords

  • caloric restriction (CR)
  • fatty acid biosynthesis
  • mitochondria
  • white adipose tissue (WAT)


Kynurenine aminotransferase isoforms display fiber-type specific expression in young and old human skeletal muscle.


Keywords

  • Aging
  • Kynurenine aminotransferases
  • Mitochondria
  • Muscle fiber-type
  • Skeletal muscle


Ubiquinol-10 delays postovulatory oocyte aging by improving mitochondrial renewal in pigs.


Keywords

  • mitochondria
  • oxidative stress
  • pig
  • postovulatory aging
  • ubiquinol-10


Mitochondrial oxidative capacity and NAD biosynthesis are reduced in human sarcopenia across ethnicities.


MeSH Terms

  • Aged
  • Aged, 80 and over
  • Aging
  • Biopsy
  • Case-Control Studies
  • Energy Metabolism
  • Humans
  • Jamaica
  • Male
  • Middle Aged
  • Mitochondria
  • Muscle, Skeletal
  • NAD
  • Oxidation-Reduction
  • Oxidative Phosphorylation
  • Oxidative Stress
  • Proteostasis
  • Sarcopenia
  • Singapore
  • United Kingdom


MicroRNA-34a (miR-34a) Mediates Retinal Endothelial Cell Premature Senescence through Mitochondrial Dysfunction and Loss of Antioxidant Activities.


Keywords

  • diabetic retinopathy
  • miR-34a
  • mitochondrial dysfunction
  • vascular senescence


Constitutive PGC-1α overexpression in skeletal muscle does not protect from age-dependent decline in neurogenesis.


MeSH Terms

  • Aging
  • Animals
  • Blood Proteins
  • Cytokines
  • Female
  • Hippocampus
  • Male
  • Mice, Inbred C57BL
  • Mice, Transgenic
  • Muscle, Skeletal
  • Neurogenesis
  • Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha
  • Reproducibility of Results

PGK2

Arsenic influences spermatogenesis by disorganizing the elongation of spermatids in adult male mice.


MeSH Terms

  • Aging
  • Animals
  • Arsenic
  • Cell Cycle Proteins
  • DEAD-box RNA Helicases
  • Gene Expression Profiling
  • Male
  • Mice
  • RNA, Messenger
  • Spermatids
  • Spermatogenesis
  • Spermatozoa

Keywords

  • Arsenic
  • Elongation of spermatids
  • Male reproduction
  • Spermatogenesis

PGLS

547 transcriptomes from 44 brain areas reveal features of the aging brain in non-human primates.


MeSH Terms

  • Aging
  • Animals
  • Brain
  • Carboxylic Ester Hydrolases
  • Macaca mulatta
  • Male
  • Mice
  • Transcriptome

Keywords

  • Brain aging
  • Multiple brain regions
  • PGLS
  • Rhesus macaques
  • Transcriptome

PIEZO1

Niche stiffness underlies the ageing of central nervous system progenitor cells.


MeSH Terms

  • Adult Stem Cells
  • Aging
  • Animals
  • Animals, Newborn
  • Cell Count
  • Central Nervous System
  • Extracellular Matrix
  • Female
  • Humans
  • Membrane Proteins
  • Multipotent Stem Cells
  • Oligodendroglia
  • Rats
  • Stem Cell Niche

PINK1

Spermidine inhibits neurodegeneration and delays aging via the PINK1-PDR1-dependent mitophagy pathway in [i]C. elegans[/i].


Keywords

  • aging
  • caenorhabditis elegans
  • mitophagy
  • neurodegenerative diseases
  • spermidine


Female mice are resilient to age-related decline of substantia nigra dopamine neuron firing parameters.


Keywords

  • Aging
  • Dopamine
  • Electrophysiology
  • Firing
  • Mouse
  • Substantia nigra


Attenuation of epigenetic regulator SMARCA4 and ERK-ETS signaling suppresses aging-related dopaminergic degeneration.


Keywords

Drosophila

  • MAPK-ERK-ETS signaling
  • Parkinson's disease
  • SMARCA4/Brahma
  • aging
  • neurodegeneration


SIRT1 alleviates high-magnitude compression-induced senescence in nucleus pulposus cells via PINK1-dependent mitophagy.


Keywords

  • SIRT1
  • compression
  • mitophagy
  • nucleus pulposus
  • senescence


Synergistic action of propolis with levodopa in the management of Parkinsonism in Drosophila melanogaster.


Keywords

  • Drosophila melanogaster
  • Levodopa induced dyskinesia
  • PINK1B9
  • Parkinsonism
  • Parkinson’s disease
  • aging
  • antioxidant activity
  • catalase
  • climbing index
  • lifespan
  • oxidative stress
  • propolis


Compression-induced senescence of nucleus pulposus cells by promoting mitophagy activation via the PINK1/PARKIN pathway.


Keywords

  • PARKIN pathway
  • PINK1
  • compression
  • intervertebral disc
  • mitophagy
  • senescence


Doxorubicin-induced normal breast epithelial cellular aging and its related breast cancer growth through mitochondrial autophagy and oxidative stress mitigated by ginsenoside Rh2.


MeSH Terms

  • Autophagy
  • Breast Neoplasms
  • Cell Culture Techniques
  • Cell Line, Tumor
  • Doxorubicin
  • Drugs, Chinese Herbal
  • Female
  • Ginsenosides
  • Humans
  • Mitochondria
  • Oxidative Stress

Keywords

  • ROS
  • cancer growth
  • cellular senescence
  • chemotherapy
  • ginsenoside Rh2
  • mitophagy


Mitochondrial DNA heteroplasmy rises in substantial nigra of aged PINK1 KO mice.


MeSH Terms

  • Aging
  • Animals
  • Brain
  • DNA Copy Number Variations
  • DNA, Mitochondrial
  • Gene Frequency
  • Mice, Knockout
  • Mutation Rate
  • Protein Kinases
  • Substantia Nigra

Keywords

  • PINK1
  • Parkin
  • Parkinson’s disease
  • mtDNA heteroplasmy

PIP

Potentially inappropriate prescriptions according to explicit and implicit criteria in patients with multimorbidity and polypharmacy. MULTIPAP: A cross-sectional study.


MeSH Terms

  • Aged
  • Cross-Sectional Studies
  • Female
  • Geriatrics
  • Humans
  • Inappropriate Prescribing
  • Independent Living
  • Male
  • Multimorbidity
  • Polypharmacy
  • Potentially Inappropriate Medication List
  • Prevalence
  • Primary Health Care
  • Risk
  • Spain


Quality of prescribing predicts hospitalisation in octogenarians: life and living in advanced age: a cohort study in New Zealand (LiLACS NZ).


MeSH Terms

  • Aged
  • Aged, 80 and over
  • Aging
  • Cohort Studies
  • Drug Prescriptions
  • Female
  • Follow-Up Studies
  • Forecasting
  • Hospitalization
  • Humans
  • Inappropriate Prescribing
  • Longitudinal Studies
  • Male
  • New Zealand
  • Patient Discharge
  • Potentially Inappropriate Medication List

Keywords

  • Appropriate prescribing
  • Ethnicity
  • Longitudinal study
  • Older people

PLIN2

Cardiac overexpression of perilipin 2 induces atrial steatosis, connexin 43 remodeling, and atrial fibrillation in aged mice.


MeSH Terms

  • Animals
  • Atrial Fibrillation
  • Connexin 43
  • Gene Knock-In Techniques
  • Heart Atria
  • Isolated Heart Preparation
  • Lipid Droplets
  • Mice
  • Mice, Transgenic
  • Microscopy, Electron
  • Myocytes, Cardiac
  • Perilipin-2
  • Sterol Esterase
  • Triglycerides
  • Voltage-Sensitive Dye Imaging

Keywords

  • aging
  • cardiac steatosis
  • gap junction
  • lipid droplets
  • lipotoxic arrhythmia

PLK4

A novel lncRNA PLK4 up-regulated by talazoparib represses hepatocellular carcinoma progression by promoting YAP-mediated cell senescence.


Keywords

  • Yes-associated protein
  • cellular senescence
  • hepatocellular carcinoma
  • polo-like kinase 4 associated lncRNA
  • talazoparib


Differential expression of AURKA/PLK4 in quiescence and senescence of osteosarcoma U2OS cells.


Keywords

  • AURKA
  • Osteosarcoma
  • PLK4
  • quiescence
  • senescence

PLN

An analysis of the costs of treating aged patients in a large clinical hospital in Poland under the pressure of recent demographic trends.


Keywords

  • Polish health care system
  • ageing society
  • gerontology
  • healthcare
  • hospital costs
  • length and cost of hospitalization

PML

Progressive multifocal leukoencephalopathy in dimethyl fumarate-treated multiple sclerosis patients.


Keywords

  • Multiple sclerosis
  • PML
  • fumarate
  • immunosenescence
  • lymphopenia


PML2-mediated thread-like nuclear bodies mark late senescence in Hutchinson-Gilford progeria syndrome.


Keywords

  • HGPS
  • PML2
  • senescence
  • thread-like PML NBs

PNN

Hyaluronan degradation and release of a hyaluronan-aggrecan complex from perineuronal nets in the aged mouse brain.


Keywords

  • Brain aging
  • Chondroitin sulfate proteoglycan
  • Extracellular matrix
  • Hyaluronan
  • Perineuronal net

PNP

Temporal Discrimination Thresholds and Proprioceptive Performance: Impact of Age and Nerve Conduction.


Keywords

  • TDMT
  • aging
  • kinesthesia
  • pointing task
  • position estimation
  • somatosensory temporal discrimination
  • temporal discrimination threshold

POLL

Temporal trends in loss of life expectancy after a cancer diagnosis among the Australian population.


MeSH Terms

  • Aged
  • Aged, 80 and over
  • Australia
  • Cancer Survivors
  • Cohort Studies
  • Female
  • Humans
  • Life Expectancy
  • Male
  • Middle Aged
  • Neoplasms

Keywords

  • Australia
  • Cancer
  • Life expectancy
  • Survival
  • Temporal

POLR3A

Nucleolar disruption, activation of P53 and premature senescence in POLR3A-mutated Wiedemann-Rautenstrauch syndrome fibroblasts.


Keywords

  • Cell senescence
  • DNA damage
  • Nucleolus
  • Nucleus
  • RNA polymerase III subunit A (POLR3A)
  • Wiedemann-Rautenstrauch syndrome

POMC

Gpr17 deficiency in POMC neurons ameliorates the metabolic derangements caused by long-term high-fat diet feeding.


MeSH Terms

  • Aging
  • Animals
  • Body Weight
  • Brain
  • Diet, High-Fat
  • Energy Metabolism
  • Female
  • Homeostasis
  • Insulin Resistance
  • Liver
  • Male
  • Mice
  • Mice, Knockout
  • Motor Activity
  • Nerve Tissue Proteins
  • Neurons
  • Pro-Opiomelanocortin
  • Receptors, G-Protein-Coupled
  • Sex Factors

POR

The Ventricular System Enlarges Abnormally in the Seventies, Earlier in Men, and First in the Frontal Horn: A Study Based on More Than 3,000 Scans.


Keywords

  • Evans’ index
  • aging
  • brain
  • enlargement
  • hydrocephalus
  • normal pressure
  • ventricular system

POT1

MiR-185 targets POT1 to induce telomere dysfunction and cellular senescence.


Keywords

  • aging
  • cellular senescence
  • miR-185
  • protection of telomere 1
  • telomere dysfunction


Seryl tRNA synthetase cooperates with POT1 to regulate telomere length and cellular senescence.


Keywords

  • Cancer genomics
  • Senescence

POU5F1

Cell quality evaluation with gene expression analysis of spheroids (3D) and adherent (2D) adipose stem cells.


Keywords

  • ALDH family
  • Adipose stem cells
  • Aging
  • Shelterin complex
  • Spheroid
  • Telomere length

PPID

Relationships of inflamm-aging with circulating nutrient levels, body composition, age, and pituitary pars intermedia dysfunction in a senior horse population.


MeSH Terms

  • Aging
  • Animals
  • Body Composition
  • Cytokines
  • Female
  • Folic Acid
  • Horse Diseases
  • Horses
  • Inflammation
  • Male
  • Nutrients
  • Pituitary Diseases
  • Pituitary Gland, Intermediate

Keywords

  • Horse
  • Inflamm-aging
  • Muscle
  • Nutrition
  • Pituitary pars intermedia dysfunction
  • Senior

PRDM8

PRDM8 reveals aberrant DNA methylation in aging syndromes and is relevant for hematopoietic and neuronal differentiation.


Keywords

  • Aging
  • Aplastic anemia
  • DNA methylation
  • Dyskeratosis congenita
  • Epigenetic clock
  • Hematopoietic differentiation
  • Neuronal differentiation
  • PRDM8
  • Telomere
  • iPSC

PRDX1

Active vitamin D supplementation alleviates initiation and progression of nonalcoholic fatty liver disease by repressing the p53 pathway.


MeSH Terms

  • Animals
  • Apoptosis
  • Cellular Senescence
  • Diet, High-Fat
  • Dietary Supplements
  • Fas Ligand Protein
  • Hepatocytes
  • Metabolic Networks and Pathways
  • Mice, Knockout
  • Non-alcoholic Fatty Liver Disease
  • Oxidative Stress
  • Proteins
  • Steroid Hydroxylases
  • Tumor Suppressor Protein p53
  • Vitamin D
  • fas Receptor

Keywords

  • Active vitamin D
  • Apoptosis
  • Nonalcoholic fatty liver disease
  • Oxidative stress
  • Senescence
  • p53 pathway

PRDX3

Proteomic analyses reveal that ginsenoside Rg3([i]S[/i]) partially reverses cellular senescence in human dermal fibroblasts by inducing peroxiredoxin.


Keywords

  • Ginsenoside Rg3(S)
  • Human dermal fibroblast
  • Label-free quantitative proteomics
  • Restoration
  • Senescence

PRDX6

Dentate Gyrus Peroxiredoxin 6 Levels Discriminate Aged Unimpaired From Impaired Rats in a Spatial Memory Task.


Keywords

  • PRDX6
  • aging
  • dentate gyrus
  • hippocampus
  • hole-board
  • peroxiredoxin
  • proteomics
  • spatial memory

PRKDC

DNA-PKcs modulates progenitor cell proliferation and fibroblast senescence in idiopathic pulmonary fibrosis.


MeSH Terms

  • Animals
  • Cell Line
  • Cell Proliferation
  • Cellular Senescence
  • Chromones
  • DNA Damage
  • DNA Repair
  • DNA-Activated Protein Kinase
  • DNA-Binding Proteins
  • Female
  • Fibroblasts
  • Humans
  • Idiopathic Pulmonary Fibrosis
  • Lung
  • Mesenchymal Stem Cells
  • Mice
  • Mice, SCID
  • Morpholines

Keywords

  • DNA-PKcs
  • IPF
  • Mesenchymal progenitor cells
  • Senescence

PRL

Mechanism of PRL2 phosphatase-mediated PTEN degradation and tumorigenesis.


MeSH Terms

  • Animals
  • Carcinogenesis
  • Female
  • HEK293 Cells
  • Humans
  • Immediate-Early Proteins
  • Longevity
  • Male
  • Mice, Inbred C57BL
  • Mice, Knockout
  • Nedd4 Ubiquitin Protein Ligases
  • PTEN Phosphohydrolase
  • Protein Tyrosine Phosphatases
  • Proto-Oncogene Proteins c-akt
  • Ubiquitination

Keywords

  • NEDD4
  • PRL2
  • PTEN
  • protein tyrosine phosphatases
  • ubiquitination


Prolactin mitigates deficiencies of retinal function associated with aging.


MeSH Terms

  • Aging
  • Animals
  • Apoptosis
  • Electroretinography
  • Mice, Inbred C57BL
  • Nerve Growth Factors
  • Neuroglia
  • Prolactin
  • Retina
  • Retinal Degeneration

Keywords

  • Aging
  • Apoptosis
  • Glia activation
  • Hormone
  • Mesotopic and photopic electroretinogram
  • Retina


A Spontaneous Aggressive ERα+ Mammary Tumor Model Is Driven by Kras Activation.


MeSH Terms

  • Aging
  • Animals
  • Carcinogenesis
  • Datasets as Topic
  • Estrogen Receptor alpha
  • Female
  • Gene Expression Profiling
  • Humans
  • Mammary Neoplasms, Experimental
  • Mice
  • Prolactin
  • Proto-Oncogene Proteins p21(ras)
  • Rats
  • Signal Transduction
  • Transgenes

Keywords

  • ER+ breast cancer
  • Ras mutations
  • breast cancer
  • genomic analyses
  • mouse models
  • prolactin

PRNP

Spontaneous generation of prions and transmissible PrP amyloid in a humanised transgenic mouse model of A117V GSS.


MeSH Terms

  • Adult
  • Aging
  • Amyloid
  • Animals
  • Brain
  • Codon
  • Heterozygote
  • Homozygote
  • Humans
  • Mice, Transgenic
  • Middle Aged
  • Prions

PROC

Does midlife aging impact women's sleep duration, continuity, and timing?: A longitudinal analysis from the Study of Women's Health Across the Nation.


Keywords

  • actigraphy
  • aging
  • sleep duration
  • sleep in women
  • sleep quality

PSD

Quantitative Immunoblotting Analyses Reveal that the Abundance of Actin, Tubulin, Synaptophysin and EEA1 Proteins is Altered in the Brains of Aged Mice.


Keywords

  • aging
  • brain
  • cortex
  • glutamate receptor
  • synapse
  • vesicle


Exercise Attenuates Brain Aging by Rescuing Down-Regulated Wnt/β-Catenin Signaling in Aged Rats.


Keywords

  • DKK-1
  • Wnt
  • brain aging
  • exercise
  • β-catenin


Concurrent nicotine exposure to prenatal alcohol consumption alters the hippocampal and cortical neurotoxicity.


Keywords

  • Aging
  • Mitochondrial function
  • Neuroscience
  • Oxidative stress

PSEN2

Accelerated brain aging towards transcriptional inversion in a zebrafish model of the K115fs mutation of human PSEN2.


MeSH Terms

  • Aging
  • Alternative Splicing
  • Alzheimer Disease
  • Animals
  • Animals, Genetically Modified
  • Brain
  • Datasets as Topic
  • Disease Models, Animal
  • Down-Regulation
  • Female
  • Frameshift Mutation
  • Gene Editing
  • Gene Regulatory Networks
  • Heterozygote
  • Humans
  • Microglia
  • Presenilin-1
  • Presenilin-2
  • Protein Isoforms
  • Proteomics
  • RNA-Seq
  • Up-Regulation
  • Zebrafish
  • Zebrafish Proteins


Loss of presenilin 2 age-dependently alters susceptibility to acute seizures and kindling acquisition.


Keywords

  • Aging
  • Alzheimer's
  • Carbamazepine
  • Corneal kindling
  • Diazepam
  • Epilepsy
  • Lamotrigine
  • Levetiracetam
  • Presenilin
  • Seizures
  • Valproic acid

PSMD11

The effect and mechanism of 19S proteasome PSMD11/Rpn6 subunit in D-Galactose induced mimetic aging models.


Keywords

  • Age-related hearing loss
  • Aging
  • D-galactose
  • PSMD11
  • Proteasome

PSMD14

Upregulation of deubiquitinase PSMD14 in lung adenocarcinoma (LUAD) and its prognostic significance.


Keywords

  • PMSD14
  • apoptosis
  • deubiquitinating enzyme
  • lung adenocarcinoma
  • prognosis
  • senescence

PTEN

Senescence Reprogramming by TIMP1 Deficiency Promotes Prostate Cancer Metastasis.


Keywords

  • FGF1
  • GDF-15
  • MMPs
  • PTEN
  • TIMP1
  • docetaxel
  • prostate cancer metastasis
  • senescence
  • senescence-associated secretory phenotype (SASP)
  • senolytic therapy


Alterations in Mitochondrial Dynamic-related Genes in the Peripheral Blood of Alzheimer's Disease Patients.


Keywords

  • Alzheimer's disease
  • DRP1
  • FIS1
  • aging
  • mitochondrial dynamics
  • mitophagy


Human ESC-sEVs alleviate age-related bone loss by rejuvenating senescent bone marrow-derived mesenchymal stem cells.


Keywords

  • Extracellular vesicle
  • bone loss
  • bone marrow MSCs
  • cellular senescence
  • embryonic stem cells


The precursor of PI(3,4,5)P alleviates aging by activating daf-18(Pten) and independent of daf-16.


MeSH Terms

  • Aging
  • Animals
  • Animals, Genetically Modified
  • Caenorhabditis elegans
  • Caenorhabditis elegans Proteins
  • Cell Line, Tumor
  • Female
  • Forkhead Transcription Factors
  • Inositol
  • Locomotion
  • Longevity
  • Metabolic Networks and Pathways
  • Metabolomics
  • Mice
  • Mitophagy
  • Models, Animal
  • PTEN Phosphohydrolase
  • Phosphatidylinositol Phosphates
  • Protein Kinases
  • Protein-Serine-Threonine Kinases
  • RNA Interference
  • RNA-Seq


Quercetin alleviates kidney fibrosis by reducing renal tubular epithelial cell senescence through the SIRT1/PINK1/mitophagy axis.


MeSH Terms

  • Animals
  • Antioxidants
  • Cell Line
  • Cellular Senescence
  • Epithelium
  • Fibrosis
  • Flow Cytometry
  • Kidney
  • Kidney Tubules, Proximal
  • Mitophagy
  • Protein Kinases
  • Quercetin
  • Rats
  • Sirtuin 1

Keywords

  • Fibrosis
  • Mitochondria
  • Mitophagy
  • Quercetin
  • Senescence


Downregulation of PTEN mediates bleomycin-induced premature senescence in lung cancer cells by suppressing autophagy.


Keywords

  • PI3K/Akt/mTOR pathway
  • PTEN
  • autophagy
  • bleomycin
  • cancer cell
  • premature senescence


miR-155 inhibits mitophagy through suppression of BAG5, a partner protein of PINK1.


MeSH Terms

  • Adaptor Proteins, Signal Transducing
  • Aging
  • Animals
  • Cell Line
  • Cells, Cultured
  • Down-Regulation
  • Humans
  • Male
  • Mesenchymal Stem Cells
  • Mice, Inbred C57BL
  • MicroRNAs
  • Mitophagy
  • Protein Interaction Maps
  • Protein Kinases
  • Up-Regulation

Keywords

  • Aging
  • Bone marrow MSCs
  • Mitophagy
  • miR-155


Environmental Exposures and Asthma Development: Autophagy, Mitophagy, and Cellular Senescence.


MeSH Terms

  • Airway Remodeling
  • Asthma
  • Autophagy
  • Cellular Senescence
  • Disease Susceptibility
  • Environmental Exposure
  • Humans
  • Mitophagy
  • Oxidative Stress
  • Respiratory Mucosa

Keywords

  • asthma
  • autophagy
  • mitophagy
  • oxidative stress
  • senescence


PTEN loss regulates alveolar epithelial cell senescence in pulmonary fibrosis depending on Akt activation.


MeSH Terms

  • Aging
  • Cellular Senescence
  • Epithelial Cells
  • Humans
  • Idiopathic Pulmonary Fibrosis
  • PTEN Phosphohydrolase
  • Proto-Oncogene Proteins c-akt
  • Pulmonary Alveoli
  • Respiratory Mucosa

Keywords

  • aging
  • cellular senescence
  • phosphatase and tension homolog deleted on chromosome ten
  • protein kinase B
  • pulmonary fibrosis

PTH

Vitamin D Receptor Polymorphisms in Sex-Frailty Paradox.


Keywords

  • aging
  • frailty
  • vitamin D
  • vitamin D receptor


Parathyroid hormone ameliorates temporomandibular joint osteoarthritic-like changes related to age.


MeSH Terms

  • Aging
  • Animals
  • Calcium-Regulating Hormones and Agents
  • Cells, Cultured
  • Disease Models, Animal
  • Male
  • Mice
  • Mice, Inbred C57BL
  • Osteoarthritis
  • Osteogenesis
  • Parathyroid Hormone
  • Temporomandibular Joint

Keywords

  • cellular senescence
  • cyclin-dependent kinase inhibitor P16INK4A
  • marrow mesenchymal stem cells
  • osteoarthritis
  • temporomandibular joint disorders

PTP4A3

Transcriptional and Functional Changes of the Human Microvasculature during Physiological Aging and Alzheimer Disease.


Keywords

  • 3D microvascular network
  • blood-brain barrier
  • endothelium
  • human serum
  • vascular aging

PTPN11

Fine mapping genetic variants associated with age at puberty and sow fertility using SowPro90 genotyping array.


Keywords

         SowPro90
       
  • Bayes interval mapping
  • custom genotyping array
  • gilts
  • puberty
  • reproductive longevity

PTTG1

[Down-regulated PTTG1 expression promotes the senescence of human prostate cancer LNCaP-AI].


MeSH Terms

  • Cell Line, Tumor
  • Cell Proliferation
  • Humans
  • Male
  • Prostatic Neoplasms, Castration-Resistant
  • RNA, Small Interfering
  • Securin
  • beta-Galactosidase

Keywords

  • LNCaP-AI cell


  • castration-resistant prostate cancer
  • cellular senescence
  • pituitary tumor-transforming gene-1
  • prostate cancer

PTX3

Aerobic Training Down-Regulates Pentraxin 3 and Pentraxin 3/Toll-Like Receptor 4 Ratio, Irrespective of Oxidative Stress Response, in Elderly Subjects.


Keywords

  • aging
  • endurance training
  • exercise
  • inflammation
  • oxidative stress
  • pentraxin 3
  • toll-like receptor 4


Sex Differences in the Association Between Pentraxin 3 and Cognitive Decline: The Cardiovascular Health Study.


Keywords

  • Biomarkers
  • Cognitive aging
  • Inflammation
  • Sex differences

PUM1

Identification of reference genes for RT-qPCR data normalisation in aging studies.


MeSH Terms

  • Aging
  • Algorithms
  • Gene Expression Profiling
  • Genes, Essential
  • Humans
  • Real-Time Polymerase Chain Reaction
  • Software

RACK1

Invariable stoichiometry of ribosomal proteins in mouse brain tissues with aging.


MeSH Terms

  • Aging
  • Animals
  • Brain
  • Female
  • Gene Expression Regulation, Developmental
  • Male
  • Mice
  • Proteomics
  • Ribosomal Proteins

Keywords

  • aging
  • mass spectrometry
  • neuronal tissues
  • ribosome
  • translation

RAF1

Circular [i]ANRIL[/i] isoforms switch from repressors to activators of [i]p15/CDKN2B[/i] expression during RAF1 oncogene-induced senescence.


Keywords

  • INK4 locus
  • Non-coding RNAs
  • Polycomb proteins
  • circular RNAs
  • gene expression regulation
  • oncogene-induced senescence

RAG1

T cell senescence accelerates Angiotensin II-induced target organ damage.


Keywords

  • T cell
  • angiotensin II
  • cardiorenal dysfunction
  • senescence

RAG2

Phosphate Transporter Profiles in Murine and Human Thymi Identify Thymocytes at Distinct Stages of Differentiation.


Keywords

  • aging
  • glucose transporters
  • human
  • metabolism
  • mice
  • phosphate transporters
  • thymus

RAN

Rapid automatized naming (RAN): effects of aging on a predictor of reading skill.


Keywords

  • Aging
  • RAN
  • individual differences
  • naming
  • reading

RELB

New control of the senescence barrier in breast cancer.


Keywords

  • CEBPB
  • Cellular senescence
  • PAK4
  • RELB
  • p21-activated kinase

REST

[Brain and Neuronal Aging: Aged Brain Controls via Gene Expression Fidelity and Master Regulatory Factors].


MeSH Terms

  • Aged
  • Aged, 80 and over
  • Aging
  • Animals
  • Brain
  • Gene Expression
  • Gene Expression Regulation, Developmental
  • Humans
  • Neurodegenerative Diseases
  • Protein Biosynthesis
  • Repressor Proteins
  • Ribosomes

Keywords

  • aging
  • brain
  • gene expression
  • neurodegeneration
  • ribosome
  • translational fidelity


Effect of 9 - PAHSA on cognitive dysfunction in diabetic mice and its possible mechanism.


MeSH Terms

  • Aging
  • Animals
  • Behavior, Animal
  • Blood Glucose
  • Body Weight
  • Brain
  • Brain-Derived Neurotrophic Factor
  • Cognitive Dysfunction
  • Diabetes Mellitus, Experimental
  • Exploratory Behavior
  • Male
  • Memory Disorders
  • Mice
  • Palmitic Acid
  • Repressor Proteins
  • Social Behavior
  • Spatial Memory
  • Stearic Acids

Keywords

  • 9-PAHSA
  • BDNF
  • Diabetes mellitus
  • REST


Increased REST to Optimize Life Span?


MeSH Terms

  • Animals
  • Caenorhabditis elegans
  • Caenorhabditis elegans Proteins
  • Homeostasis
  • Longevity
  • Repressor Proteins
  • Signal Transduction

Keywords

  • life span
  • neuronal activity
  • neurotoxicity

RET

Effects of resistance exercise training on redox homeostasis in older adults. A systematic review and meta-analysis.


Keywords

  • Aging
  • Antioxidants
  • Exercise
  • Oxidative stress
  • Resistance exercise training


Effects of an 8-week resistance training intervention on plantar flexor muscle quality and functional capacity in older women: A randomised controlled trial.


Keywords

  • Aging
  • Muscle echo intensity
  • Muscle quality
  • Physical function
  • Resistance training


Resistance exercise training promotes fiber type-specific myonuclear adaptations in older adults.


Keywords

  • aging
  • hypertrophy
  • myonuclear domain
  • skeletal muscle


Low skeletal muscle capillarization limits muscle adaptation to resistance exercise training in older adults.


MeSH Terms

  • Adaptation, Physiological
  • Aged
  • Capillaries
  • Citrate (si)-Synthase
  • Exercise
  • Female
  • Humans
  • Hypertrophy
  • Male
  • Muscle Fibers, Skeletal
  • Muscle Proteins
  • Muscle, Skeletal
  • Resistance Training
  • Sarcopenia
  • Ubiquitin-Protein Ligases

Keywords

  • Aging
  • Capillary
  • Fiber cross-sectional area
  • Muscle hypertrophy
  • Muscle protein synthesis

REV1

REV1 inhibitor JH-RE-06 enhances tumor cell response to chemotherapy by triggering senescence hallmarks.


Keywords

  • Rev1
  • cell death
  • chemotherapy
  • senescence
  • translesion synthesis

RHEB

The Rheb-TORC1 signaling axis functions as a developmental checkpoint.


MeSH Terms

  • Animals
  • Animals, Genetically Modified
  • Autophagy
  • CRISPR-Cas Systems
  • Caenorhabditis elegans
  • Caenorhabditis elegans Proteins
  • Life Cycle Stages
  • Longevity
  • Mechanistic Target of Rapamycin Complex 1
  • Phosphotransferases (Alcohol Group Acceptor)
  • RNA Interference
  • RNA, Small Interfering
  • Ras Homolog Enriched in Brain Protein
  • Signal Transduction

Keywords

  • MTOR
  • MTORC1
  • Ral
  • RalGAP
  • TSC
  • Tuberous sclerosis complex

RHO

Conditional reprogramming: next generation cell culture.


Keywords

  • 3T3-J2 fibroblast
  • AACR, American Association for Cancer Research
  • ACC, adenoid cystic carcinoma
  • AR, androgen receptor
  • CFTR, cystic fibrosis transmembrane conductance regulators
  • CR, conditional reprogramming
  • CYPs, cytochrome P450 enzymes
  • Conditional reprogramming
  • DCIS, ductal carcinoma in situ
  • ECM, extracellular matrix
  • ESC, embryonic stem cell
  • HCMI, human cancer model initiatives
  • HGF, hepatocyte growth factor
  • HNE, human nasal epithelial
  • HPV, human papillomaviruses
  • ICD, intracellular domain
  • LECs, limbal epithelial cells
  • NCI, National Cancer Institute
  • NGFR, nerve growth factor receptor
  • NSCLC, non-small cell lung cancer
  • NSG, NOD/SCID/gamma
  • PDAC, pancreatic ductal adenocarcinoma
  • PDX, patient derived xenograft
  • PP2A, protein phosphatase 2A
  • RB, retinoblastoma-associated protein
  • ROCK
  • ROCK, Rho kinase
  • SV40, simian virus 40 large tumor antigen
  • Senescence
  • UVB, ultraviolet radiation b
  • Y-27632
  • dECM, decellularized extracellular matrix
  • hASC, human adipose stem cells
  • hTERT, human telomerase reverse transcriptase
  • iPSCs, induction of pluripotent stem cells
  • ΔNP63α, N-terminal truncated form of P63α


SARS-CoV-2 receptor ACE2 and TMPRSS2 are primarily expressed in bronchial transient secretory cells.


MeSH Terms

  • Adult
  • Aging
  • Angiotensin-Converting Enzyme 2
  • Bronchi
  • COVID-19
  • Cells, Cultured
  • Chronic Disease
  • Coronavirus Infections
  • Epithelial Cells
  • Female
  • Gene Expression
  • Gene Expression Profiling
  • Germany
  • Goblet Cells
  • Humans
  • Lung
  • Male
  • Middle Aged
  • Pandemics
  • Peptidyl-Dipeptidase A
  • Pneumonia, Viral
  • Reference Standards
  • Sequence Analysis, RNA
  • Serine Endopeptidases
  • Sex Characteristics
  • Single-Cell Analysis
  • Smoking
  • Tissue Banks

Keywords

FURIN

  • COVID-19
  • Human Cell Atlas
  • epithelial differentiation
  • respiratory tract

RICTOR

Endothelial senescence-associated secretory phenotype (SASP) is regulated by Makorin-1 ubiquitin E3 ligase.


MeSH Terms

  • Cellular Senescence
  • Endothelial Cells
  • Human Umbilical Vein Endothelial Cells
  • Humans
  • MicroRNAs
  • Nerve Tissue Proteins
  • Phosphorylation
  • Protein Binding
  • Rapamycin-Insensitive Companion of mTOR Protein
  • Ribonucleoproteins
  • Telomeric Repeat Binding Protein 2
  • Ubiquitin-Protein Ligases

Keywords

  • Inflammation
  • MKRN1
  • Senescence
  • Senescence-associated secretory phenotype (SASP)
  • Telomeric repeat binding factor 2-interacting protein (TERF2IP)
  • p90RSK

RIF1

53BP1 Enforces Distinct Pre- and Post-resection Blocks on Homologous Recombination.


MeSH Terms

  • Aging
  • Animals
  • BRCA1 Protein
  • DNA Breaks, Double-Stranded
  • DNA Damage
  • Genomic Instability
  • Homologous Recombination
  • Mice
  • Mutation
  • Poly(ADP-ribose) Polymerase Inhibitors
  • Rad51 Recombinase
  • Tumor Suppressor p53-Binding Protein 1
  • Ubiquitin-Protein Ligases

Keywords

  • 53BP1
  • BRCA1
  • PARPi
  • aging
  • cancer
  • homologous recombination
  • resection
  • shieldin

RIPK1

Casein kinase 1G2 suppresses necroptosis-promoted testis aging by inhibiting receptor-interacting kinase 3.


Keywords

  • aging
  • cell biology
  • mouse
  • necroptosis
  • protein kinase
  • reproductivity
  • testis


Crucial role of the terminal complement complex in chondrocyte death and hypertrophy after cartilage trauma.


Keywords

  • Aurintricarboxylic acid
  • Cartilage trauma
  • Hypertrophy
  • Regulated cell death
  • Senescence
  • Terminal complement complex

RIPK3

Metformin mediates cardioprotection against aging-induced ischemic necroptosis.


MeSH Terms

  • Aging
  • Animals
  • Autophagy
  • GTPase-Activating Proteins
  • Humans
  • Hypoglycemic Agents
  • Imidazoles
  • Indoles
  • Male
  • Metformin
  • Mice
  • Mice, Inbred C57BL
  • Mice, Knockout
  • Myocardium
  • Myocytes, Cardiac
  • Necroptosis
  • Protein Binding
  • RNA, Small Interfering
  • Receptor-Interacting Protein Serine-Threonine Kinases
  • Reperfusion Injury
  • Sequestosome-1 Protein

Keywords

  • aging
  • autophagy defect
  • cardioprotection
  • ischemia/reperfusion injury
  • metformin
  • myocardial necroptosis

RNF10

Reduced RING finger protein 10 expression in macrophages is associated with aging-related inflammation.


Keywords

  • E3 ubiquitin ligase
  • RNF10
  • immunosenescence
  • inflammation
  • macrophages

RNF13

The effects of environmental stressors on candidate aging associated genes.


Keywords

  • Aging
  • Candidate genes
  • Environmental factors
  • Epigenetic
  • Hypo/hyper methylated (methylation)

ROCK2

Physical exercise increases ROCK activity in the skeletal muscle of middle-aged rats.


Keywords

  • Aging
  • Insulin resistance
  • Physical exercise
  • Rho-kinase (ROCK)

RPE

Transcriptomic Profiling of Human Pluripotent Stem Cell-derived Retinal Pigment Epithelium over Time.


Keywords

  • Aging
  • Human embryonic stem cell
  • Human pluripotent stem cell
  • Retinal pigment epithelium
  • Single-cell RNA sequencing


Relationship between Oxygen Uptake, Heart Rate, and Perceived Effort in an Aquatic Incremental Test in Older Women.


Keywords

  • aging
  • cardiorespiratory
  • maximum test
  • rate of perceived exertion
  • water aerobics
  • water-based exercises


Photoreceptor Degeneration in Homozygous Male Per2 Mice During Aging.


Keywords

  • Per2luc
  • aging
  • circadian
  • mice
  • photoreceptors
  • retinal pigment epithelium


An In-Vitro Cell Model of Intracellular Protein Aggregation Provides Insights into RPE Stress Associated with Retinopathy.


Keywords

  • AMD
  • RPE
  • aging
  • autofluorescence
  • autophagy
  • diet
  • lysosomes
  • oxidized POS
  • proteolysis
  • retina


Short-Term Effect of Self-Selected Training Intensity on Ambulatory Blood Pressure in Hypertensive Older Women: A Randomized Controlled Trial.


Keywords

  • aging
  • exercise
  • hypertension


Correlation between brain volume and retinal photoreceptor outer segment volume in normal aging and neurodegenerative diseases.


MeSH Terms

  • Aged
  • Aging
  • Brain
  • Female
  • Humans
  • Linear Models
  • Magnetic Resonance Imaging
  • Male
  • Middle Aged
  • Multivariate Analysis
  • Neurodegenerative Diseases
  • Organ Size
  • Retinal Photoreceptor Cell Outer Segment
  • Retinal Pigment Epithelium
  • Tomography, Optical Coherence


Oxidative stress in the retina and retinal pigment epithelium (RPE): Role of aging, and DJ-1.


Keywords

  • Aging
  • DJ-1
  • Oxidative stress
  • Retina
  • Retinal pigment epithelium
  • Sodium iodate


Direct-Coupled Electroretinogram (DC-ERG) for Recording the Light-Evoked Electrical Responses of the Mouse Retinal Pigment Epithelium.


MeSH Terms

  • Aging
  • Animals
  • Electrophysiological Phenomena
  • Electroretinography
  • Light
  • Mice
  • Retinal Pigment Epithelium


High-density lipoproteins are a potential therapeutic target for age-related macular degeneration.


Keywords

  • age-related macular degeneration
  • aging
  • apolipoprotein
  • complement
  • complement factor H
  • glycosaminoglycan
  • heparan sulfate
  • heparan sulfate proteoglycans
  • high-density lipoprotein (HDL)
  • lipoprotein
  • oligosaccharide
  • retinal degeneration
  • retinal pigmented epithelium


MTOR-initiated metabolic switch and degeneration in the retinal pigment epithelium.


Keywords

  • AMD
  • Mtor
  • aging
  • lipid
  • metabolism


[i]Lactobacillus paracasei[/i] KW3110 Suppresses Inflammatory Stress-Induced Premature Cellular Senescence of Human Retinal Pigment Epithelium Cells and Reduces Ocular Disorders in Healthy Humans.


Keywords

  • cellular senescence
  • eye fatigue
  • inflammation
  • lactic acid bacteria
  • probiotics
  • retina


Retinal pigment epithelium transcriptome analysis in chronic smoking reveals a suppressed innate immune response and activation of differentiation pathways.


Keywords

  • Age-related macular degeneration
  • Aging
  • Differentiation
  • Innate immunity
  • RNA sequencing
  • Smoking


Differences in Intraretinal Pigment Migration Across Inherited Retinal Dystrophies.


MeSH Terms

  • Adult
  • Aging
  • Cell Movement
  • Female
  • Follow-Up Studies
  • Humans
  • Male
  • Ophthalmoscopy
  • Retinal Dystrophies
  • Retinal Pigment Epithelium
  • Retrospective Studies
  • Slit Lamp Microscopy
  • Tomography, Optical Coherence


Exosomal MiRNA Transfer between Retinal Microglia and RPE.


Keywords

  • RPE
  • aging
  • exosome
  • inflammation
  • microglia


Functionally validated imaging endpoints in the Alabama study on early age-related macular degeneration 2 (ALSTAR2): design and methods.


Keywords

  • Age-related macular degeneration
  • Aging
  • Cones
  • Dark adaptation
  • Light sensitivity
  • Macula
  • Quantitative autofluorescence
  • Retina
  • Rods
  • Spectral domain optical coherence tomography


Mechanisms of mitochondrial dysfunction and their impact on age-related macular degeneration.


Keywords

  • Age-related macular degeneration
  • Aggregation
  • Aging
  • Autophagy
  • Clearance
  • Degeneration
  • Mitochondria
  • Mitophagy
  • Retina
  • Retinal pigment epithelium


CSF1R blockade induces macrophage ablation and results in mouse choroidal vascular atrophy and RPE disorganization.


Keywords

  • RPE disorganization
  • aging
  • choroid
  • choroidal macrophage
  • choroidal vasculature
  • immunology
  • inflammation
  • mouse
  • neuroscience


Extracellular microparticles exacerbate oxidative damage to retinal pigment epithelial cells.


Keywords

  • Extracellular vesicles
  • Oxidative stress
  • Phagocytosis
  • RPE cell Dysfunction
  • RPE cell-Derived microparticles (RMPs)
  • Retinal pigment epithelial cell (RPE)
  • Senescence


Water-based continuous and interval training in older women: Cardiorespiratory and neuromuscular outcomes (WATER study).


Keywords

  • Aerobic capacity
  • Aerobic training
  • Aging
  • Aquatic exercise
  • Interval exercise
  • Muscle echo intensity
  • Muscle strength
  • Muscle thickness


Retrieval Practice Improves Recollection-Based Memory Over a Seven-Day Period in Younger and Older Adults.


Keywords

  • aging
  • recollection and familiarity
  • retrieval practice
  • temporal dynamics
  • testing effect


A Comparison of Heart Rate Training Load and Perceptual Effort Between Masters and Young Cyclists


MeSH Terms

  • Adult
  • Aging
  • Bicycling
  • Heart Rate
  • High-Intensity Interval Training
  • Humans
  • Middle Aged
  • Perception
  • Physical Exertion

Keywords

  • age
  • endurance training
  • high-intensity interval training
  • older athlete


Retinal Pigment Epithelial Cells: The Unveiled Component in the Etiology of Prpf Splicing Factor-Associated Retinitis Pigmentosa.


MeSH Terms

  • Animals
  • Circadian Rhythm
  • Epithelial Cells
  • Eye Proteins
  • Humans
  • Mice
  • Phagocytosis
  • Photoreceptor Cells, Vertebrate
  • RNA Splicing Factors
  • Retinal Pigment Epithelium
  • Retinitis Pigmentosa

Keywords

  • Aging
  • Cellular stress
  • Circadian rhythm
  • Metabolism
  • PRPF
  • Phagocytosis
  • Retinal pigment epithelium
  • Retinitis pigmentosa
  • Splicing factors


AMPK May Play an Important Role in the Retinal Metabolic Ecosystem.


MeSH Terms

  • AMP-Activated Protein Kinases
  • Animals
  • DNA Damage
  • DNA, Mitochondrial
  • Disease Models, Animal
  • Gene Dosage
  • Metformin
  • Mice
  • Oxidative Stress
  • Retina
  • Retinal Degeneration
  • Retinitis Pigmentosa

Keywords

  • AMPK
  • Adenosine monophosphate-activated protein kinase
  • Aging
  • Glycolysis
  • Metabolism
  • Neuroprotection
  • Retina


Stem cell-derived retinal pigment epithelium from patients with age-related macular degeneration exhibit reduced metabolism and matrix interactions.


Keywords

  • Bruch's membrane
  • age-related macular degeneration
  • aging
  • induced pluripotent stem cells
  • nonenzymatic nitration
  • retinal pigment epithelium


Elovanoids counteract oligomeric β-amyloid-induced gene expression and protect photoreceptors.


MeSH Terms

  • Amyloid beta-Peptides
  • Animals
  • Apoptosis
  • Autophagy
  • Cells, Cultured
  • Docosahexaenoic Acids
  • Extracellular Matrix
  • Fatty Acids, Omega-3
  • Gene Expression Regulation
  • Humans
  • Male
  • Mice, Inbred C57BL
  • Mice, Transgenic
  • Photoreceptor Cells
  • Retina
  • Retinal Pigment Epithelium
  • Young Adult

Keywords

  • SASP
  • age-related macular degeneration
  • p16
  • retinal pigment epithelial cells
  • senescence gene program


Genetic LAMP2 deficiency accelerates the age-associated formation of basal laminar deposits in the retina.


MeSH Terms

  • Aging
  • Animals
  • Basement Membrane
  • Bruch Membrane
  • Exocytosis
  • Humans
  • Lysosomal-Associated Membrane Protein 2
  • Lysosomes
  • Macular Degeneration
  • Mice
  • Mice, Knockout
  • Phagocytosis
  • Retina
  • Retinal Pigment Epithelium

Keywords

  • LAMP2
  • aging
  • lysosome
  • retinal degeneration


Age, lipofuscin and melanin oxidation affect fundus near-infrared autofluorescence.


MeSH Terms

  • Age Factors
  • Animals
  • Biomarkers
  • Choroid
  • Disease Models, Animal
  • Female
  • Fluorescein Angiography
  • Fundus Oculi
  • Humans
  • Lipofuscin
  • Macular Degeneration
  • Male
  • Melanins
  • Melanosomes
  • Mice
  • Mice, Knockout
  • Optical Imaging
  • Oxidation-Reduction
  • Oxidative Stress
  • Protein Transport
  • Retinal Pigment Epithelium
  • Tomography, Optical Coherence

Keywords

  • Aging
  • Lipofuscin
  • Melanin
  • Melanolipofuscin
  • Oxidative stress


Relevance of working memory for reinforcement learning in older adults varies with timescale of learning.


Keywords

  • Aging
  • computational modeling
  • individual differences
  • reinforcement learning
  • working memory


Expression and Function of Mas-Related G Protein-Coupled Receptor D and Its Ligand Alamandine in Retina.


MeSH Terms

  • Aging
  • Angiotensin II
  • Animals
  • Cells, Cultured
  • Electroretinography
  • Humans
  • Ligands
  • Lipopolysaccharides
  • Mice, Inbred C57BL
  • Mice, Knockout
  • Oligopeptides
  • Rats
  • Reactive Oxygen Species
  • Receptors, G-Protein-Coupled
  • Retina

Keywords

  • Alamandine
  • Angiotensin-(1–7)
  • Mas-related G protein-coupled receptor D
  • Rennin-angiotensin system
  • Retina

RPIA

Suppression of p16 Induces mTORC1-Mediated Nucleotide Metabolic Reprogramming.


MeSH Terms

  • Aldose-Ketose Isomerases
  • Animals
  • Cell Line
  • Cellular Senescence
  • Cyclin-Dependent Kinase Inhibitor p16
  • Gene Knockdown Techniques
  • Humans
  • Male
  • Mechanistic Target of Rapamycin Complex 1
  • Mice, SCID
  • Nucleotides
  • Pentose Phosphate Pathway
  • Protein Biosynthesis

Keywords

  • BRAF
  • cancer metabolism
  • cell cycle
  • melanoma
  • nevi
  • pancreatic cancer
  • pentose phosphate pathway
  • ribonucleotide reductase M2
  • ribose-5-phosphate isomerase A
  • senescence

RPS19BP1

Material basis, effect, and mechanism of ethanol extract of Pinellia ternata tubers on oxidative stress-induced cell senescence.


Keywords

  • Oxidative stress
  • Pinellia ternata
  • SIRT1
  • Senescence

RTEL1

Telomere length and aging-related outcomes in humans: A Mendelian randomization study in 261,000 older participants.


MeSH Terms

  • Adult
  • Aged
  • Aged, 80 and over
  • Aging
  • Cohort Studies
  • Female
  • Humans
  • Male
  • Mendelian Randomization Analysis
  • Middle Aged
  • Risk Factors
  • Telomere Homeostasis

Keywords

  • TERT
  • UK Biobank
  • anti-aging
  • cellular senescence
  • centenarians
  • frailty
  • longevity
  • sarcopenia

RXFP3

The RXFP3 receptor is functionally associated with cellular responses to oxidative stress and DNA damage.


MeSH Terms

  • Camptothecin
  • Computational Biology
  • DNA Damage
  • Felodipine
  • GTPase-Activating Proteins
  • Gene Expression Regulation
  • Gene Regulatory Networks
  • HEK293 Cells
  • Humans
  • Oxidative Stress
  • RNA, Messenger
  • Receptors, G-Protein-Coupled
  • Topoisomerase I Inhibitors

Keywords

  • DNA damage
  • GPCR
  • aging
  • relaxin 3
  • relaxin family peptide 3 receptor

S100A4

Protective role of mesenchymal stem cells and mesenchymal stem cell-derived exosomes in cigarette smoke-induced mitochondrial dysfunction in mice.


MeSH Terms

  • Alarmins
  • Animals
  • Cytokines
  • Exosomes
  • Lung
  • Mesenchymal Stem Cells
  • Mice
  • Mitochondria
  • Mitophagy
  • Oxidative Phosphorylation
  • Smoke
  • Tobacco

Keywords

  • COPD
  • Cellular Senescence
  • Exosomes
  • Mesenchymal stem cells
  • Mitochondria

S100A9

Cigarette smoke induction of S100A9 contributes to chronic obstructive pulmonary disease.


Keywords

  • Cigarette smoke
  • S100A9
  • aging
  • kinase
  • pulmonary function


Modulation of KDM1A with vafidemstat rescues memory deficit and behavioral alterations.


MeSH Terms

  • Aging
  • Alzheimer Disease
  • Animals
  • Behavior, Animal
  • Brain
  • Disease Models, Animal
  • Enzyme Inhibitors
  • Epigenesis, Genetic
  • Female
  • Gene Expression
  • Hippocampus
  • Histone Demethylases
  • Humans
  • Male
  • Memory Disorders
  • Mice
  • Mice, Inbred C57BL
  • Mice, Mutant Strains
  • Monoamine Oxidase Inhibitors
  • Oxadiazoles
  • Rats
  • Rats, Sprague-Dawley


Cellular senescence induced by S100A9 in mesenchymal stromal cells through NLRP3 inflammasome activation.


MeSH Terms

  • Adolescent
  • Adult
  • Aged
  • Aged, 80 and over
  • Calgranulin B
  • Case-Control Studies
  • Cell Line
  • Cells, Cultured
  • Cellular Reprogramming
  • Cellular Senescence
  • Female
  • Humans
  • Inflammasomes
  • Interleukin-1beta
  • Male
  • Mesenchymal Stem Cells
  • Middle Aged
  • Myelodysplastic Syndromes
  • NLR Family, Pyrin Domain-Containing 3 Protein
  • Reactive Oxygen Species
  • Signal Transduction
  • Stem Cell Niche
  • Toll-Like Receptor 4
  • Up-Regulation
  • Young Adult

Keywords

  • NLRP3
  • S100A9
  • cellular senescence
  • mesenchymal stromal cells
  • myelodysplastic syndromes


S100A9 extends lifespan in insulin deficiency.


MeSH Terms

  • Animals
  • Calgranulin B
  • Diabetes Mellitus, Experimental
  • Diphtheria Toxin
  • Fatty Acids
  • Humans
  • Hyperglycemia
  • Insulin
  • Leptin
  • Liver
  • Longevity
  • Male
  • Mice
  • Mice, Knockout
  • Oxidation-Reduction
  • Signal Transduction
  • Streptozocin
  • Toll-Like Receptor 4

S100B

Aging protects rat cortical slices against to oxygen-glucose deprivation induced damage.


Keywords

  • Aging
  • LDH
  • S100B
  • edema
  • oxygen-glucose deprivation

S1PR1

Aging Suppresses Sphingosine-1-Phosphate Chaperone ApoM in Circulation Resulting in Maladaptive Organ Repair.


Keywords

  • aging
  • endothelial cell
  • fibrosis
  • kidney repair
  • lipoprotein
  • lung regeneration
  • sphingosine-1-phosphate receptor
  • vascular barrier
  • vascular niche

SAG

WRKY42 transcription factor positively regulates leaf senescence through modulating SA and ROS synthesis in Arabidopsis thaliana.


Keywords

WRKY42

  • Arabidopsis
  • leaf senescence
  • reactive oxygen species
  • salicylic acid


Neurogenesis in the inner ear: the zebrafish statoacoustic ganglion provides new neurons from a Neurod/Nestin-positive progenitor pool well into adulthood.


MeSH Terms

  • Adult Stem Cells
  • Aging
  • Animals
  • Animals, Genetically Modified
  • Basic Helix-Loop-Helix Transcription Factors
  • Cell Differentiation
  • Ear, Inner
  • Embryo, Nonmammalian
  • Ganglia, Sensory
  • Gene Expression Regulation, Developmental
  • Hair Cells, Auditory
  • Larva
  • Nerve Tissue Proteins
  • Nestin
  • Neural Stem Cells
  • Neurogenesis
  • Sensory Receptor Cells
  • Stem Cell Niche
  • Zebrafish

Keywords

  • Inner ear
  • Neuronal stem cells
  • PNS
  • Zebrafish

SAT1

Triethylenetetramine (trientine): a caloric restriction mimetic with a new mode of action.


Keywords

  • Acetylation
  • SAT1
  • aging
  • autophagy
  • copper
  • metabolomics
  • obesity
  • spermidine

SATB1

Loss of SATB1 Induces p21-Dependent Cellular Senescence in Post-mitotic Dopaminergic Neurons.


MeSH Terms

  • Aging
  • Animals
  • Cells, Cultured
  • Cellular Senescence
  • Cyclin-Dependent Kinase Inhibitor p21
  • Dopaminergic Neurons
  • Epigenetic Repression
  • Gene Knockdown Techniques
  • Humans
  • Matrix Attachment Region Binding Proteins
  • Mice
  • Mice, Knockout
  • Mitosis
  • Parkinson Disease
  • Protein Binding

Keywords

  • Parkinson’s disease
  • SATB1
  • cellular senescence
  • dopamine
  • neurodegeneration
  • neuroinflammation
  • p21
  • senolytics
  • stem cells
  • transcriptomics

SCD

Cognitive training and brain stimulation in prodromal Alzheimer's disease (AD-Stim)-study protocol for a double-blind randomized controlled phase IIb (monocenter) trial.


Keywords

  • Aging
  • Decision-making
  • Mild cognitive impairment
  • Subjective cognitive decline
  • Transcranial direct current stimulation
  • Transfer
  • Working memory


Blood Pressure in Different Dementia Disorders, Mild Cognitive Impairment, and Subjective Cognitive Decline.


Keywords

  • Alzheimer’s disease
  • aging
  • blood pressure
  • mild cognitive impairment
  • subjective cognitive decline


Known-Groups and Convergent Validity of the Telephone Rey Auditory Verbal Learning Test total Learning Scores for Distinguishing Between Older Adults With Amnestic Cognitive Impairment and Subjective Cognitive Decline.


Keywords

  • aging
  • cognitive impairment
  • neuropsychological assessment


Subjective cognitive decline as a predictor of future cognitive decline: a systematic review.


Keywords

  • Alzheimer disease.
  • aging
  • cognition
  • cognitive dysfunction
  • dementia


Geriatric assessment for older adults with sickle cell disease: protocol for a prospective cohort pilot study.


Keywords

  • Aging
  • Functional assessment
  • Geriatric assessment
  • Geriatrics
  • Older adults
  • Sickle cell


Prevalence and psychosocial correlates of subjectively perceived decline in five cognitive domains: Results from a population-based cohort study in Germany.


Keywords

  • Germany
  • cognitive aging
  • cognitive complaints
  • cohort study
  • prevalence
  • subjective cognitive decline


SC411 treatment can enhance survival in a mouse model of sickle cell disease.


Keywords

  • Aging
  • Cerebral blood flow
  • Docosahexaenoic acid
  • Neuroinflammation
  • Sickle cell disease
  • Working memory


DNA fragmentation of human spermatozoa: Simple assessment of single- and double-strand DNA breaks and their respective dynamic behavioral response.


Keywords

  • DNA longevity
  • sperm DNA damage
  • sperm DNA dynamics
  • sperm DNA fragmentation
  • sperm chromatin dispersion test


Psychometric Cognitive Decline Precedes the Advent of Subjective Cognitive Decline in the Evolution of Alzheimer's Disease.


Keywords

  • Alzheimer’s disease
  • Brain aging
  • Cognitive decline
  • Cognitive testing
  • Longitudinal studies
  • Psychometric cognition


Serum alkaline phosphatase is elevated and inversely correlated with cognitive functions in subjective cognitive decline: results from the ReGAl 2.0 project.


Keywords

  • Aging
  • Biochemistry
  • Cognition
  • Dementia
  • Geriatric medicine


Changes in Activity Participation Among Older Adults With Subjective Cognitive Decline or Objective Cognitive Deficits.


Keywords

  • activity participation
  • aging
  • daily functioning
  • metamemory
  • subjective cognitive decline


Age, gender and drug therapy influences on Tpeak-tend interval and on electrical risk score.


Keywords

  • Aging
  • Electrical risk score
  • Gender
  • Mortality
  • QTc
  • Repolarization phase
  • T peak-tend interval


Comorbid Chronic Conditions Among Older Adults with Subjective Cognitive Decline, United States, 2015-2017.


Keywords

  • Aging
  • Chronic disease
  • Cognitive dysfunction
  • Dementia


Resting State BOLD Variability Is Linked to White Matter Vascular Burden in Healthy Aging but Not in Older Adults With Subjective Cognitive Decline.


Keywords

  • Alzheimer’s disease
  • aging
  • biomarkers
  • cerebrovascular health
  • signal variability
  • subjective cognitive decline
  • white matter


Estimated Life Expectancy and Income of Patients With Sickle Cell Disease Compared With Those Without Sickle Cell Disease.


MeSH Terms

  • Adolescent
  • Adult
  • Aged
  • Anemia, Sickle Cell
  • Child
  • Child, Preschool
  • Cohort Studies
  • Female
  • Forecasting
  • Humans
  • Income
  • Infant
  • Life Expectancy
  • Male
  • Middle Aged
  • Models, Statistical
  • Quality-Adjusted Life Years
  • United States
  • Young Adult


Does Empirically Derived Classification of Individuals with Subjective Cognitive Complaints Predict Dementia?


Keywords

  • Compostela aging study
  • cluster analysis
  • cognitive aging
  • dementia
  • mild cognitive impairment
  • screening and diagnosis
  • subjective cognitive complaints


Spatiotemporal Oscillatory Patterns During Working Memory Maintenance in Mild Cognitive Impairment and Subjective Cognitive Decline.


MeSH Terms

  • Aged
  • Aging
  • Brain Waves
  • Cerebral Cortex
  • Cognitive Dysfunction
  • Cortical Synchronization
  • Female
  • Humans
  • Magnetoencephalography
  • Male
  • Memory, Short-Term
  • Task Performance and Analysis

Keywords

  • Alzheimer’s disease (AD)
  • Induced oscillatory activity
  • magnetoencephalography (MEG)
  • mild cognitive impairment (MCI)
  • subjective cognitive decline (SCD)
  • working memory (WM)


Microstructural Correlates and Laterality Effect of Prospective Memory in Non-Demented Adults with Memory Complaints.


MeSH Terms

  • Aged
  • Aged, 80 and over
  • Corpus Callosum
  • Diffusion Tensor Imaging
  • Female
  • Frontal Lobe
  • Functional Laterality
  • Humans
  • Magnetic Resonance Imaging
  • Male
  • Memory Disorders
  • Middle Aged
  • Nerve Fibers
  • Neuropsychological Tests
  • Retrospective Studies
  • Surveys and Questionnaires
  • Taiwan

Keywords

  • Aging
  • Alzheimer’s disease
  • Cognitive complaints
  • Diffusion tensor imaging
  • Lateralization
  • Prospective memory
  • Tract-based spatial statistics

SCN2A

Na 1.2 haploinsufficiency in Scn2a knock-out mice causes an autistic-like phenotype attenuated with age.


MeSH Terms

  • Aging
  • Animals
  • Autism Spectrum Disorder
  • Gene Knockout Techniques
  • Haploinsufficiency
  • Memory
  • Mice
  • NAV1.2 Voltage-Gated Sodium Channel
  • Phenotype
  • Spatial Learning

SCN2B

MicroRNA‑449a regulates the progression of brain aging by targeting SCN2B in SAMP8 mice.


MeSH Terms

  • Aging
  • Animals
  • Brain
  • Gene Expression Regulation
  • Male
  • Mice
  • Mice, Transgenic
  • MicroRNAs
  • Voltage-Gated Sodium Channel beta-2 Subunit

SCO1

Real-Time PCR Analysis of Metabolism-Related Genes in a Long-Lived Model of C. elegans.


Keywords

  • Caenorhabditis elegans
  • Energy metabolism
  • Longevity
  • TaqMan real-time PCR
  • p53/CEP-1

SDC1

Olmesartan alleviates bleomycin-mediated vascular smooth muscle cell senescence via the miR-665/SDC1 axis.


Keywords

  • Atherosclerosis
  • MiR-665
  • SDC1
  • olmesartan
  • vascular smooth muscle cell senescence


Sulfated syndecan 1 is critical to preventing cellular senescence by modulating fibroblast growth factor receptor endocytosis.


Keywords

  • FGFR1
  • SDC1
  • cellular senescence
  • endocytosis
  • heparan sulfation

SDHB

Mitochondrial Signatures in Circulating Extracellular Vesicles of Older Adults with Parkinson's Disease: Results from the EXosomes in PArkiNson's Disease (EXPAND) Study.


Keywords

  • aging
  • biomarkers
  • exosomes
  • mitochondrial dynamics
  • mitochondrial quality control
  • mitochondrial-derived vesicles
  • mitochondrial-lysosomal axis
  • mitophagy

SDS

Semiautomatic morphometric analysis of skeletal muscle obtained by needle biopsy in older adults.


Keywords

  • Aging skeletal muscle
  • Morphometric analysis
  • Myosin heavy chain
  • Semiautomatic muscle analysis
  • Skeletal muscle


Effects of late-onset dietary intake of salidroside on insulin/insulin-like growth factor-1 (IGF-1) signaling pathway of the annual fish Nothobranchius guentheri.


Keywords

  • Aging
  • Annual fish
  • Lifespan
  • Nothobranchius
  • Salidroside


Quantification of Insoluble Protein Aggregation in Caenorhabditis elegans during Aging with a Novel Data-Independent Acquisition Workflow.


MeSH Terms

  • Aging
  • Animals
  • Caenorhabditis elegans
  • Caenorhabditis elegans Proteins
  • Longevity
  • Protein Aggregates
  • Proteome
  • Proteomics
  • Workflow


Skeletal Muscle Myofibrillar Protein Abundance Is Higher in Resistance-Trained Men, and Aging in the Absence of Training May Have an Opposite Effect.


Keywords

  • aging
  • myofibrillar protein
  • proteomics
  • resistance training
  • sarcoplasmic protein


Characterization, evaluation of nutritional parameters of Radix isatidis protein and its antioxidant activity in D-galactose induced ageing mice.


MeSH Terms

  • Aging
  • Animals
  • Antioxidants
  • Catalase
  • Drugs, Chinese Herbal
  • Galactose
  • Humans
  • Kidney
  • Liver
  • Male
  • Malondialdehyde
  • Mice
  • Mice, Inbred ICR
  • Molecular Weight
  • Oxidative Stress
  • Plant Proteins
  • Plant Roots
  • Superoxide Dismutase

Keywords

  • Antioxidant activity
  • D-galactose
  • Oxidative damage
  • Protein composition
  • Radix isatidis protein


[Effects of silver nanoparticles on pupation, eclosion, life span, apoptosis and protein expression in Drosophila melanogaster].


MeSH Terms

  • Animals
  • Apoptosis
  • Drosophila melanogaster
  • Longevity
  • Metal Nanoparticles
  • Oregon
  • Silver

Keywords

  • Drosophila melanogaster
  • apoptosis
  • protein expression
  • silver nanoparticles


Does an Age-Specific Treatment Program Augment the Efficacy of a Cognitive-Behavioral Weight Loss Program in Adolescence and Young Adulthood? Results from a Controlled Study.


MeSH Terms

  • Adolescent
  • Aging
  • Behavior Therapy
  • Cognitive Behavioral Therapy
  • Female
  • Humans
  • Male
  • Weight Loss
  • Weight Reduction Programs
  • Young Adult

Keywords

  • adolescents
  • behavioral weight loss
  • controlled trial
  • emerging adults
  • obesity
  • quality of life

SELENBP1

A Caenorhabditis elegans ortholog of human selenium-binding protein 1 is a pro-aging factor protecting against selenite toxicity.


MeSH Terms

  • Animals
  • Caenorhabditis elegans
  • Caenorhabditis elegans Proteins
  • Cytoplasm
  • Drug Resistance
  • Gene Expression Regulation
  • Humans
  • Longevity
  • Membrane Proteins
  • Oxidative Stress
  • Paraquat
  • Selenious Acid
  • Selenium-Binding Proteins
  • Structural Homology, Protein

Keywords

  • Caenorhabditis elegans
  • Lifespan
  • Selenium-binding protein
  • Stress signaling

SELENOK

Dietary selenium deficiency and supplementation differentially modulate the expression of two ER-resident selenoproteins (selenoprotein K and selenoprotein M) in the ovaries of aged mice: Preliminary data.


Keywords

  • Female fertility
  • Ovarian aging
  • Selenium
  • Selenoprotein K
  • Selenoprotein M

SENP6

Molecular signature for senile and complicated cataracts derived from analysis of sumoylation enzymes and their substrates in human cataract lenses.


Keywords

  • Pax6
  • SUMO1
  • SUMO2/3
  • aging
  • apoptosis
  • cataract
  • de-sumoylation enzymes (SENPs)
  • sumoylation ligases

SERPINE1

Elevated circulating HtrA4 in preeclampsia may alter endothelial expression of senescence genes.


Keywords

  • Endothelial aging
  • Endothelial cells
  • HtrA4
  • Preeclampsia
  • Senescence

SESN2

Copy Number Alterations in Papillary Thyroid Carcinomas: Does Loss of [i]SESN2[/i] Have a Role in Age-related Different Prognoses?


Keywords

  • Papillary thyroid cancer
  • SESN2
  • aCGH
  • deletion
  • senescence

SFN

The phytoprotective agent sulforaphane prevents inflammatory degenerative diseases and age-related pathologies via Nrf2-mediated hormesis.


Keywords

  • Aging
  • Hormesis
  • Inflammation
  • Neuroprotection
  • Nrf2
  • Sulforaphane


Multi-Omic Analysis Reveals Different Effects of Sulforaphane on the Microbiome and Metabolome in Old Compared to Young Mice.


Keywords

  • aging
  • biomarkers
  • gut microbiome
  • metabolome
  • sulforaphane


Sulforaphane controls the release of paracrine factors by keratinocytes and thus mitigates particulate matter-induced premature skin aging by suppressing melanogenesis and maintaining collagen homeostasis.


Keywords

  • Coculture system
  • Collagen homeostasis
  • Melanogenesis
  • Particulate matter 2.5
  • Premature skin aging
  • Sulforaphane


Sulforaphane Inhibits Autophagy and Induces Exosome-Mediated Paracrine Senescence via Regulating mTOR/TFE3.


Keywords

  • ROS
  • autophagy
  • exosome
  • senescence
  • sulforaphane

SFPQ

Downregulation of LncRNA NORAD promotes Ox-LDL-induced vascular endothelial cell injury and atherosclerosis.


Keywords

  • IL-8
  • NORAD
  • cell apoptosis
  • cell senescence
  • ox-LDL

SGK1

Epigenetic Regulation of KL (Klotho) via H3K27me3 (Histone 3 Lysine [K] 27 Trimethylation) in Renal Tubule Cells.


Keywords

  • AKT
  • EZH2
  • aging
  • mTOR
  • p53

SHBG

Endogenous Testosterone Levels and the Risk of Incident Cardiovascular Events in Elderly Men: The MrOS Prospective Study.


Keywords

  • aging
  • cardiovascular events
  • men
  • testosterone


Associations of Endogenous Sex Hormones with Carotid Plaque Burden and Characteristics in Midlife Women.


Keywords

  • aging
  • atherosclerosis
  • carotid artery
  • hormones
  • women


Analysis of the Relationship between the Levels of Androgens and Biochemical Bone Markers in Men Aged 60-75 Years.


MeSH Terms

  • Absorptiometry, Photon
  • Aged
  • Aging
  • Androgens
  • Biomarkers
  • Bone Density
  • Bone Remodeling
  • Bone and Bones
  • Collagen Type I
  • Dehydroepiandrosterone Sulfate
  • Estradiol
  • Humans
  • Male
  • Middle Aged
  • Parathyroid Hormone
  • Peptide Fragments
  • Peptides
  • Procollagen
  • Sex Hormone-Binding Globulin
  • Testosterone

Keywords

  • aging men
  • biochemical bone markers
  • levels of androgens


Testosterone and Estrone Increase From the Age of 70 Years: Findings From the Sex Hormones in Older Women Study.


MeSH Terms

  • Aged
  • Aged, 80 and over
  • Aging
  • Biomarkers
  • Community-Based Participatory Research
  • Cross-Sectional Studies
  • Dehydroepiandrosterone
  • Estrone
  • Female
  • Follow-Up Studies
  • Humans
  • Obesity
  • Overweight
  • Prognosis
  • Testosterone

SHD

Does self-reported hearing difficulty decrease older adults' cognitive and physical functioning? The mediating role of social isolation.


MeSH Terms

  • Activities of Daily Living
  • Aged
  • Aged, 80 and over
  • Cognition
  • Cognitive Dysfunction
  • Cohort Studies
  • Disabled Persons
  • Female
  • Health Status
  • Hearing Loss
  • Humans
  • Longevity
  • Longitudinal Studies
  • Male
  • Mental Status and Dementia Tests
  • Odds Ratio
  • Self Report
  • Social Isolation

Keywords

  • Cognitive impairment
  • Older people
  • Physical disability
  • Self-reported hearing difficulty
  • Social isolation

SHH

Recent advances in SHH medulloblastoma progression: tumor suppressor mechanisms and the tumor microenvironment.


MeSH Terms

  • Animals
  • Cerebellar Neoplasms
  • Cerebellum
  • Hedgehog Proteins
  • Humans
  • Medulloblastoma
  • Mice
  • Tumor Microenvironment

Keywords

  • Medulloblastoma
  • Sonic hedgehog
  • cell senescence
  • tumor microenvironment
  • tumor progression

SI

Microarray Profiling Reveals Distinct Circulating miRNAs in Aged Male and Female Mice Subjected to Post-stroke Social Isolation.


Keywords

  • Aging
  • Biomarkers
  • Sex differences
  • Social isolation
  • Stroke
  • miRNAs


Is Heart Rate a Confounding Factor for Photoplethysmography Markers? A Systematic Review.


MeSH Terms

  • Aging
  • Cardiovascular Diseases
  • Diabetes Mellitus, Type 2
  • Female
  • Fingers
  • Heart Rate
  • Humans
  • Male
  • Microcirculation
  • Photoplethysmography
  • Vascular Stiffness

Keywords

  • cardiovascular disease
  • heart rate
  • photoplethysmography
  • reflection index
  • second derivative of photoplethysmography
  • stiffness index


Survival time after marked reduction in oral intake in terminally ill noncancer patients: A retrospective study.


Keywords

  • elderly
  • geriatrics
  • palliative medicine


Adherence to Mediterranean diet moderates the association between multimorbidity and depressive symptoms in older adults.


MeSH Terms

  • Aged
  • Aged, 80 and over
  • Cohort Studies
  • Depression
  • Diet, Mediterranean
  • Healthy Aging
  • Humans
  • Multimorbidity
  • Surveys and Questionnaires

Keywords

  • Aging
  • Depressive symptoms
  • Mediterranean diet
  • Mental health
  • Multimorbidity


Loneliness, Social Isolation, and Objectively Measured Physical Activity in Rural-Living Older Adults.


Keywords

  • accelerometry
  • aging
  • health
  • social well-being
  • volunteering


The associations between social support and negative social interaction with suicidal ideation in US Chinese older adults.


Keywords

  • Chinese American
  • Social support
  • aging
  • negative social interaction
  • suicidal ideation


Cell Senescence and Cerebral Small Vessel Disease in the Brains of People Aged 80 Years and Older.


MeSH Terms

  • Aged, 80 and over
  • Aging
  • Brain
  • Cellular Senescence
  • Cerebral Arteries
  • Cerebral Small Vessel Diseases
  • Female
  • Humans
  • Male
  • White Matter

Keywords

  • Brain aging
  • Cerebrovascular disease
  • Senescence
  • Small vessel disease

SIK3

Quantitative and Qualitative Role of Antagonistic Heterogeneity in Genetics of Blood Lipids.


Keywords

  • Age-related phenotypes
  • Aging
  • Genome-wide association studies
  • Health span
  • Life span
  • Pleiotropy

SIRT1

Anthocyanins attenuate endothelial dysfunction through regulation of uncoupling of nitric oxide synthase in aged rats.


Keywords

  • NO
  • SIRT1
  • anthocyanins
  • eNOS deacetylation
  • senescence


Sirtuins and Their Implications in Neurodegenerative Diseases from a Drug Discovery Perspective.


Keywords

  • Aging
  • neurodegenerative diseases
  • neuroprotective
  • sirtuin
  • sirtuin activators
  • sirtuin inhibitors


Effects of alpha-mangostin on memory senescence induced by high glucose in human umbilical vein endothelial cells.


Keywords

  • Cellular senescence
  • Diabetes
  • Diabetes complications
  • Endothelial cells
  • Garcinia mangostana
  • Hyperglycemia
  • Mangostin
  • Metabolic syndrome


SIRT1 Activation Using CRISPR/dCas9 Promotes Regeneration of Human Corneal Endothelial Cells through Inhibiting Senescence.


Keywords

  • CRISPR/dCas9
  • SIRT1
  • corneal endothelial cells
  • senescence


Histone Deacetylase SIRT1, Smooth Muscle Cell Function, and Vascular Diseases.


Keywords

  • SIRT1
  • SIRT1 activators
  • calorie restriction
  • senescence
  • vascular diseases
  • vascular smooth muscle cells


6,4'-dihydroxy-7-methoxyflavanone protects against H O -induced cellular senescence by inducing SIRT1 and inhibiting phosphatidylinositol 3-kinase/Akt pathway activation.


Keywords

  • 6,4′-dihydroxy-7-methoxyflavanone
  • Akt
  • Oxidative stress
  • Premature senescence
  • SIRT1


Isoparvifuran isolated from Dalbergia odorifera attenuates H O -induced senescence of BJ cells through SIRT1 activation and AKT/mTOR pathway inhibition.


Keywords

  • AKT/mTOR signaling pathway
  • Antioxidant: SIRT1
  • Cellular senescence
  • Isoparvifuran


SIRT1 Is the Target Gene for 2,3,5,4'-Tetrahydroxystilbene-2-O-β-D-Glucoside Alleviating the HUVEC Senescence.


Keywords

  • 2,3,5,4’-tetrahydroxystilbene-2-O-β-d-glucoside
  • SIRT1
  • human umbilical vein cells
  • hydrogen peroxide
  • senescence


The Role of Sirtuins in Kidney Diseases.


Keywords

  • acute kidney injury
  • aging kidney
  • chronic kidney disease
  • diabetic nephropathy
  • kidney
  • sirtuins


The effect of 12-week resistance exercise training on serum levels of cellular aging process parameters in elderly men.


Keywords

  • Cellular senescence
  • Elderly
  • Resistance training


Virus-Induced Asthma Exacerbations: SIRT1 Targeted Approach.


Keywords

  • SIRT1
  • asthma
  • cellular senescence
  • exacerbations
  • virus infection


Novel resveratrol derivatives have diverse effects on the survival, proliferation and senescence of primary human fibroblasts.


Keywords

  • Resveratrol
  • SIRT1
  • Senescence
  • Toxicity


Glucose restriction delays senescence and promotes proliferation of HUVECs via the AMPK/SIRT1-FOXA3-Beclin1 pathway.


Keywords

  • Beclin1
  • Endothelial cells
  • FOXA3
  • Glucose restriction
  • Proliferation
  • Senescence


Therapeutic Effects of SRT2104 on Lung Injury in Rats with Emphysema via Reduction of Type II Alveolar Epithelial Cell Senescence.


Keywords

  • Sirtuin 1
  • alveolar epithelial cells
  • cellular senescence
  • chronic obstructive pulmonary disease
  • cigarette smoking


Latifolin Inhibits Oxidative Stress-Induced Senescence via Upregulation of SIRT1 in Human Dermal Fibroblasts.


Keywords

  • human dermal fibroblast
  • latifolin
  • mammalian target of rapamycin
  • oxidative stress
  • senescence
  • silent information regulator 1


SRT1720-induced activation of SIRT1 alleviates vascular smooth muscle cell senescence through PKA-dependent phosphorylation of AMPKα at Ser485.


Keywords

  • SIRT1
  • SRT1720
  • VSMC senescence
  • p-AMPK (Ser485)
  • telomere length


miR-128 plays a critical role in murine osteoclastogenesis and estrogen deficiency-induced bone loss.


Keywords

  • PMOP
  • aging
  • inflammation
  • miR-128
  • osteoclastogenesis
  • ovariectomy


Lymphocyte senescence in COPD is associated with decreased sirtuin 1 expression in steroid resistant pro-inflammatory lymphocytes.


Keywords

  • CD28nullCD8+ T and NKT-like cells
  • COPD
  • IFNγ and TNFα
  • SIRT1
  • lymphocyte senescence


Therapeutic effects of hydro-alcoholic leaf extract of Withania somnifera on age-induced changes in daily rhythms of Sirt1, Nrf2 and Rev-erbα in the SCN of male Wistar rats.


Keywords

  • Aging
  • Ashwagandha
  • Circadian clock
  • NRF2
  • SCN
  • SIRT1


The Serum Concentration of Anti-Aging Proteins, Sirtuin1 and αKlotho in Patients with End-Stage Kidney Disease on Maintenance Hemodialysis.


MeSH Terms

  • Age Factors
  • Aged
  • Aging
  • Biomarkers
  • Blood Pressure
  • Cardiovascular Diseases
  • Case-Control Studies
  • Diabetes Complications
  • Echocardiography
  • Female
  • Glucuronidase
  • Heart Ventricles
  • Humans
  • Kidney
  • Kidney Failure, Chronic
  • Male
  • Middle Aged
  • Renal Dialysis
  • Sirtuin 1
  • Stroke Volume

Keywords

  • chronic kidney disease
  • hemodialysis
  • sirtuin1
  • αKlotho


Small extracellular vesicles deliver miR-21 and miR-217 as pro-senescence effectors to endothelial cells.


Keywords

  • Cellular senescence
  • DNMT1
  • SIRT1
  • extracellular vesicles
  • microRNAs


Spatiotemporal gating of SIRT1 functions by O-GlcNAcylation is essential for liver metabolic switching and prevents hyperglycemia.


MeSH Terms

  • Acetylglucosamine
  • Aging
  • Animals
  • Fasting
  • Gluconeogenesis
  • Glycosylation
  • HEK293 Cells
  • Homeostasis
  • Humans
  • Hyperglycemia
  • Insulin Resistance
  • Liver
  • Male
  • Mice
  • Mice, Inbred C57BL
  • Obesity
  • Phosphorylation
  • Protein Processing, Post-Translational
  • Sirtuin 1
  • Spatio-Temporal Analysis

Keywords

  • PGC1α
  • fed–fast cycle
  • gluconeogenesis
  • insulin signaling
  • ubiquitinylation


Hydrogen Sulfide Inhibits Homocysteine-Induced Neuronal Senescence by Up-Regulation of SIRT1.


Keywords

  • SIRT1
  • cell senescence
  • homocysteine
  • hydrogen sulfide


SIRT1 and aging related signaling pathways.


Keywords

  • Aging
  • Deacetylate
  • NAD(+)
  • SIRT1
  • Signaling pathways


Tropisetron protects against brain aging via attenuating oxidative stress, apoptosis and inflammation: The role of SIRT1 signaling.


MeSH Terms

  • Aging
  • Animals
  • Antioxidants
  • Apoptosis
  • Brain
  • Drug Administration Schedule
  • Galactose
  • Gene Expression Regulation
  • Inflammation
  • Injections, Intraperitoneal
  • Injections, Subcutaneous
  • Interleukin-6
  • Male
  • Mice
  • Mitochondria
  • Neurons
  • Nitric Oxide
  • Oxidative Stress
  • Proto-Oncogene Proteins c-bcl-2
  • Reactive Oxygen Species
  • Serotonin 5-HT3 Receptor Antagonists
  • Sirtuin 1
  • Tropisetron
  • Tumor Necrosis Factor-alpha
  • bcl-2-Associated X Protein

Keywords

  • Aging
  • Brain
  • Neurotoxicity
  • Sirtuin 1
  • Tropisetron
  • d-galactose


Nicotinamide mononucleotide (NMN) supplementation promotes neurovascular rejuvenation in aged mice: transcriptional footprint of SIRT1 activation, mitochondrial protection, anti-inflammatory, and anti-apoptotic effects.


Keywords

  • Aging
  • Geroscience
  • Mitochondria dysfunction
  • Transcriptomics
  • Vascular cognitive impairment


Deacetylation of MRTF-A by SIRT1 defies senescence induced down-regulation of collagen type I in fibroblast cells.


MeSH Terms

  • Acetylation
  • Animals
  • Benzamides
  • Carbazoles
  • Cellular Senescence
  • Collagen Type I
  • Down-Regulation
  • Embryo, Mammalian
  • Fibroblasts
  • HEK293 Cells
  • Heterocyclic Compounds, 4 or More Rings
  • Humans
  • Mice
  • Mutation
  • Naphthols
  • Primary Cell Culture
  • Promoter Regions, Genetic
  • RNA, Small Interfering
  • Resveratrol
  • Sirtuin 1
  • Trans-Activators

Keywords

  • Collagen type I
  • Fibroblast
  • Lysine deacetylation
  • Post-translational modification
  • Senescence
  • Transcriptional regulation


Chronic Polyphenon-60 or Catechin Treatments Increase Brain Monoamines Syntheses and Hippocampal SIRT1 Levels Improving Cognition in Aged Rats.


MeSH Terms

  • Age Factors
  • Animals
  • Behavior, Animal
  • Biogenic Monoamines
  • Catechin
  • Cognition
  • Cognitive Aging
  • Corpus Striatum
  • Hippocampus
  • Male
  • Memory, Episodic
  • Memory, Short-Term
  • Neuroprotective Agents
  • Rats, Sprague-Dawley
  • Sirtuin 1
  • Time Factors

Keywords

  • NF-κB
  • RBAP46/48
  • SIRT1
  • brain aging
  • brain monoamine synthesis
  • catechin
  • green tea
  • memory


Duck Oil-loaded Nanoemulsion Inhibits Senescence of Angiotensin II-treated Vascular Smooth Muscle Cells by Upregulating SIRT1.


Keywords

  • SIRT1
  • angiotensin II
  • duck oil
  • nanoemulsion
  • senescence


Two novel SIRT1 activators, SCIC2 and SCIC2.1, enhance SIRT1-mediated effects in stress response and senescence.


Keywords

  • Sirtuins
  • drug discovery
  • epigenetic modulators
  • senescence
  • stress response


Hydrogen sulfide attenuates mitochondrial dysfunction-induced cellular senescence and apoptosis in alveolar epithelial cells by upregulating sirtuin 1.


MeSH Terms

  • A549 Cells
  • Alveolar Epithelial Cells
  • Apoptosis
  • Cellular Senescence
  • Humans
  • Hydrogen Sulfide
  • Mitochondria
  • Oxidative Stress
  • Sirtuin 1
  • Smoke
  • Tobacco
  • Up-Regulation

Keywords

  • alveolar epithelial cell
  • cigarette smoke extract
  • hydrogen sulfide
  • mitochondria injury
  • senescence


The protective role of omentin-1 in IL-1β-induced chondrocyte senescence.


MeSH Terms

  • Adipokines
  • Caveolin 1
  • Cell Line, Tumor
  • Cellular Senescence
  • Chondrocytes
  • Cyclin-Dependent Kinase Inhibitor p21
  • Cytoprotection
  • G1 Phase Cell Cycle Checkpoints
  • Humans
  • Interleukin-1beta
  • Plasminogen Activator Inhibitor 1
  • Sirtuin 1
  • Transcriptional Activation

Keywords

  • IL-1β
  • Omentin-1
  • SIRT-1
  • chondrocyte senescence


The Lifespan Extension Ability of Nicotinic Acid Depends on Whether the Intracellular NAD Level Is Lower than the Sirtuin-Saturating Concentrations.


MeSH Terms

  • Animals
  • Caenorhabditis elegans
  • Caenorhabditis elegans Proteins
  • Caloric Restriction
  • Cell Line
  • Humans
  • NAD
  • Niacin
  • Sirtuins
  • beta-Galactosidase

Keywords

  • C. elegans
  • Hs68 cells
  • NAD+
  • calorie restriction mimetic
  • lifespan
  • nicotinic acid


Alpha-mangostin decreased cellular senescence in human umbilical vein endothelial cells.


Keywords

  • Alpha-mangostin
  • Diabetes
  • HUVEC
  • High glucose
  • SIRT1
  • Senescence


Central nervous system SIRT1 expression is required for cued and contextual fear conditioning memory responses in aging mice.


Keywords

  • Fear conditioning
  • SIRT1
  • aging
  • classically conditioned memory
  • hippocampus


Does education level protect us from rapid ageing? Sirtuin expression versus age and level of education.


MeSH Terms

  • Adolescent
  • Adult
  • Age Factors
  • Aging
  • Aging, Premature
  • Educational Status
  • Epigenesis, Genetic
  • Female
  • Gene Expression Regulation, Enzymologic
  • Histones
  • Humans
  • Learning
  • Male
  • Middle Aged
  • Sirtuins
  • Young Adult


CO ameliorates endothelial senescence induced by 5-fluorouracil through SIRT1 activation.


MeSH Terms

  • Antioxidants
  • Carbon Monoxide
  • Cellular Senescence
  • Down-Regulation
  • Fluorouracil
  • Heme Oxygenase-1
  • Human Umbilical Vein Endothelial Cells
  • Humans
  • Nitric Oxide Synthase Type III
  • Reactive Oxygen Species
  • Sirtuin 1

Keywords

  • 5-Fluorouracil
  • Carbon monoxide
  • Endothelial senescence
  • Reactive oxygen species
  • SIRT1


Long noncoding RNA GAS5 inhibits cell proliferation and fibrosis in diabetic nephropathy by sponging miR-221 and modulating SIRT1 expression.


MeSH Terms

  • Aging
  • Animals
  • Argonaute Proteins
  • Cell Proliferation
  • Diabetes Mellitus, Experimental
  • Diabetic Nephropathies
  • Fibrosis
  • Gene Deletion
  • Gene Expression Regulation
  • Glucose
  • Male
  • Mesangial Cells
  • Mice
  • MicroRNAs
  • RAW 264.7 Cells
  • RNA, Long Noncoding
  • Rats
  • Rats, Sprague-Dawley
  • Sirtuin 1

Keywords

  • diabetic nephropathy
  • fibrosis
  • lncRNA GAS5
  • proliferation


The Role of Sirtuin1 in Regulating Endothelial Function, Arterial Remodeling and Vascular Aging.


Keywords

  • PVAT
  • SIRT1
  • eNOS
  • vascular aging
  • vascular remodeling


Deacetylation of LAMP1 drives lipophagy-dependent generation of free fatty acids by Abrus agglutinin to promote senescence in prostate cancer.


Keywords

  • Abrus agglutinin
  • LAMP1
  • SIRT1
  • free fatty acid
  • lipophagy
  • reactive oxygen species
  • senescence


Plasma exosomes in OSA patients promote endothelial senescence: effect of long-term adherent continuous positive airway pressure.


Keywords

  • CPAP
  • OSA
  • aging
  • cardiovascular
  • endothelium
  • exosomes
  • extracellular vesicles
  • intermittent hypoxia
  • oxidative stress
  • senescence


Hydrogen Sulfide Inhibits High Glucose-Induced Neuronal Senescence by Improving Autophagic Flux [i]via[/i] Up-regulation of SIRT1.


Keywords

  • SIRT1
  • autophagic flux
  • high glucose
  • hydrogen sulfide
  • neuronal senescence


Activation of the miR-34a-Mediated SIRT1/mTOR Signaling Pathway by Urolithin A Attenuates D-Galactose-Induced Brain Aging in Mice.


MeSH Terms

  • Aging
  • Animals
  • Brain
  • Coumarins
  • Galactose
  • Male
  • Mice
  • Mice, Inbred ICR
  • MicroRNAs
  • PC12 Cells
  • Random Allocation
  • Rats
  • Signal Transduction
  • Sirtuin 1
  • TOR Serine-Threonine Kinases

Keywords

  • D-Gal
  • SIRT1/mTOR signal pathway
  • Urolithin A
  • aging
  • autophagy
  • miR-34a

SIRT2

Melatonin ameliorates the advanced maternal age-associated meiotic defects in oocytes through the SIRT2-dependent H4K16 deacetylation pathway.


Keywords

  • aging
  • histone acetylation
  • meiosis
  • melatonin
  • oocyte quality

SIRT3

SIRT3 protects endothelial cells from high glucose-induced senescence and dysfunction via the p53 pathway.


Keywords

  • Endothelial senescence
  • High glucose
  • SIRT3
  • p53


Melatonin and Sirtuins in Buccal Epithelium: Potential Biomarkers of Aging and Age-Related Pathologies.


Keywords

  • aging
  • arterial hypertension
  • buccal epithelium
  • melatonin
  • sirtuins


[i]SIRT3[/i] Transfection of Aged Human Bone Marrow-Derived Mesenchymal Stem Cells Improves Cell Therapy-Mediated Myocardial Repair.


Keywords

  • O-hMSC transplantation
  • SIRT3
  • aging
  • gene modification
  • myocardial infarction
  • myocardial repair


17β-estradiol inhibits H O -induced senescence in HUVEC cells through upregulating SIRT3 expression and promoting autophagy.


Keywords

  • 17β-estradiol
  • Autophagy
  • SIRT3
  • Senescence


CR6 interacting factor 1 deficiency induces premature senescence via SIRT3 inhibition in endothelial cells.


Keywords

  • Antioxidant system
  • Mitochondria
  • Oxidative stress
  • Senescence
  • Vascular endothelial cell


Mitochondrial function in skeletal myofibers is controlled by a TRF2-SIRT3 axis over lifetime.


Keywords

  • aging
  • mitochondria
  • postmitotic cells
  • skeletal muscle
  • telomeres


Context-Dependent Roles for SIRT2 and SIRT3 in Tumor Development Upon Calorie Restriction or High Fat Diet.


Keywords

  • SIRT2
  • SIRT3
  • aging
  • calorie restriction
  • cancer
  • high fat diet


The yin and yang faces of the mitochondrial deacetylase sirtuin 3 in age-related disorders.


MeSH Terms

  • Aging
  • Animals
  • Cardiovascular Diseases
  • Humans
  • Metabolic Diseases
  • Mitochondria
  • Neurodegenerative Diseases
  • Protein Isoforms
  • Sirtuin 3

Keywords

  • Age-related diseases
  • Deacetylation
  • Genetic manipulations
  • Mitochondria
  • Pharmacological modulators
  • Sirtuins

SIRT5

Lysine malonylation and propionylation are prevalent in human lens proteins.


MeSH Terms

  • Aging
  • Animals
  • Blotting, Western
  • Chromatography, Liquid
  • Crystallins
  • Cytoskeletal Proteins
  • Cytosol
  • Epithelial Cells
  • Humans
  • Immunohistochemistry
  • Lens, Crystalline
  • Lysine
  • Malonates
  • Membrane Proteins
  • Mice, Inbred C57BL
  • Mice, Knockout
  • Middle Aged
  • Mitochondrial Proteins
  • Organ Culture Techniques
  • Paraffin Embedding
  • Propionates
  • Sirtuin 3
  • Sirtuins
  • Tandem Mass Spectrometry

Keywords

  • Lens proteins
  • Malonylation
  • Mass spectrometry
  • Propionylation
  • Sirtuins

SIRT6

Association between SIRT6 Methylation and Human Longevity in a Chinese Population.


Keywords

  • DNA Methylation
  • Longevity
  • Messenger RNA
  • SIRT6


The SIRT6 activator MDL-800 improves genomic stability and pluripotency of old murine-derived iPS cells.


Keywords

  • DNA repair
  • MDL-800
  • SIRT6
  • aging
  • genome integrity
  • pluripotency


Sirtuins as Possible Predictors of Aging and Alzheimer's Disease Development: Verification in the Hippocampus and Saliva.


Keywords

  • Alzheimer’s disease
  • aging
  • intravital diagnosis
  • saliva
  • sirtuins


Age-related epigenetic drift deregulates [i]SIRT6[/i] expression and affects its downstream genes in human peripheral blood mononuclear cells.


Keywords

  • SIRT6
  • aging
  • interaction network
  • longevity
  • methylation
  • miRNA
  • peripheral blood mononuclear cells (PBMCs)


Biological and catalytic functions of sirtuin 6 as targets for small-molecule modulators.


Keywords

  • SIRT6
  • activator
  • aging
  • cancer
  • cell metabolism
  • chromatin
  • gene expression
  • histone deacetylase (HDAC)
  • longevity
  • metabolic disorder
  • sirtuin
  • small molecule


Age-dependent role of SIRT6 in jawbone via regulating senescence and autophagy of bone marrow stromal cells.


MeSH Terms

  • Adult
  • Aged
  • Aging
  • Animals
  • Bone Marrow Cells
  • Humans
  • Jaw
  • Male
  • Mesenchymal Stem Cells
  • Mice
  • Mice, Knockout
  • Middle Aged
  • Osteogenesis
  • Sirtuins

Keywords

  • Autophagy
  • Bone marrow stromal cells
  • Jawbone
  • Osteoporosis
  • SIRT6
  • Senescence


Mechanism of activation for the sirtuin 6 protein deacylase.


MeSH Terms

  • Allosteric Regulation
  • Biocatalysis
  • Fatty Acids
  • HEK293 Cells
  • Histones
  • Humans
  • Hydrophobic and Hydrophilic Interactions
  • Kinetics
  • Lipids
  • Mutagenesis
  • Mutation
  • NAD
  • Peptides
  • Protein Binding
  • Protein Conformation
  • Sirtuins
  • Small Molecule Libraries

Keywords

  • SIRT6
  • activator
  • cancer
  • chromatin
  • deacetylation
  • epigenetics
  • histone
  • histone deacetylase (HDAC)
  • lifespan
  • long chain acyl substrate
  • longevity
  • sirtuin


Proteomics of Long-Lived Mammals.


Keywords

  • SIRT6
  • aging
  • long-lived mammals
  • naked mole rats
  • proteomics


Sirtuins and SIRT6 in Carcinogenesis and in Diet.


MeSH Terms

  • Aging
  • Animals
  • Carcinogenesis
  • Diet
  • Gene Expression Regulation, Neoplastic
  • Humans
  • Nanomedicine
  • Organ Specificity
  • Sirtuins

Keywords

  • SIRT6
  • cancer
  • chemotherapy
  • diet
  • modulator
  • sirtuins


SIRT6-mediated transcriptional suppression of MALAT1 is a key mechanism for endothelial to mesenchymal transition.


MeSH Terms

  • Aging
  • Animals
  • Cells, Cultured
  • Disease Models, Animal
  • Endothelium, Vascular
  • Epithelial-Mesenchymal Transition
  • Gene Expression Regulation
  • Male
  • Mice
  • Mice, Inbred C57BL
  • Mice, Knockout
  • RNA, Long Noncoding
  • Signal Transduction
  • Sirtuins
  • Vascular Diseases

SIRT7

SIRT7 antagonizes human stem cell aging as a heterochromatin stabilizer.


Keywords

  • LINE1
  • SIRT7
  • STING
  • aging
  • cGAS
  • stem cell

SLA

Vaccination of aged mice with adjuvanted recombinant influenza nucleoprotein enhances protective immunity.


Keywords

  • Adjuvant
  • Aging
  • Influenza
  • Mouse
  • Nucleoprotein
  • Vaccination


Mechanical Anisotropy and Surface Roughness in Additively Manufactured Parts Fabricated by Stereolithography (SLA) Using Statistical Analysis.


Keywords

  • Taguchi methods
  • additive manufacturing
  • aging effect
  • analysis of variance
  • anisotropy
  • design of experiments
  • stereolithography
  • surface roughness
  • tensile testing


The Effect of Age of Titanium Dental Implants on Implant Survival and Marginal Bone Resorption: A 5-Year Retrospective Follow-Up Study.


Keywords

           aged implant
         
       
           biological aging
         
       
           implant survival
         
       
           marginal bone resorption
         
       
           titanium dental implant

SLC16A7

Genetics of facial telangiectasia in the Rotterdam Study: a genome-wide association study and candidate gene approach.


Keywords

  • GWAS
  • KIAA0930
  • MC1R
  • SLCA45A2
  • SNP
  • Telangiectasia
  • candidate gene approach
  • epidemiology
  • genetics
  • pigmentation genes
  • red veins
  • skin aging

SLC26A2

Phenotypic characterization of Slc26a2 mutant mice reveals a multifactorial etiology of spondylolysis.


MeSH Terms

  • Aging
  • Animals
  • Lumbar Vertebrae
  • Male
  • Mice
  • Osteogenesis
  • Phenotype
  • Spondylolysis
  • Sulfate Transporters

Keywords

  • SLC26A2
  • bone loss
  • isthmic defect
  • spondylolysis
  • vertebral development

SLC6A4

The Psilocybin-Telomere Hypothesis: An empirically falsifiable prediction concerning the beneficial neuropsychopharmacological effects of psilocybin on genetic aging.


MeSH Terms

  • Aging
  • Aging, Premature
  • Animals
  • Anxiety
  • Brain-Derived Neurotrophic Factor
  • Consciousness
  • DNA Methylation
  • Depression
  • Disease Models, Animal
  • Endocrine System
  • Humans
  • Models, Genetic
  • Models, Psychological
  • Neurotransmitter Agents
  • Oxidative Stress
  • Personality
  • Psilocybin
  • Psychotropic Drugs
  • Research Design
  • Serotonin Plasma Membrane Transport Proteins
  • Stress, Psychological
  • Telomere Shortening

Keywords

  • Cellular senescence
  • Depression
  • Epigenetic clock
  • Genetic aging
  • Life extension
  • Neurophenomenology
  • Psilocybin
  • Rejuvenation
  • Rumination
  • Senotherapy
  • Telomeres

SMAD1

TGFB1-Mediated Gliosis in Multiple Sclerosis Spinal Cords Is Favored by the Regionalized Expression of HOXA5 and the Age-Dependent Decline in Androgen Receptor Ligands.


MeSH Terms

  • Age Factors
  • Aged
  • Aging
  • Brain
  • Data Mining
  • Databases, Genetic
  • Disease Progression
  • Female
  • Gene Expression Profiling
  • Gliosis
  • Homeodomain Proteins
  • Humans
  • Ligands
  • Male
  • Middle Aged
  • Multiple Sclerosis
  • Proteomics
  • Receptors, Androgen
  • Sequence Analysis, RNA
  • Signal Transduction
  • Smad1 Protein
  • Spinal Cord
  • Transforming Growth Factor beta1
  • Up-Regulation

Keywords

  • androgen receptor
  • astrocytes
  • homeobox A5
  • multiple sclerosis
  • spinal cord
  • transforming growth factor beta 1

SMAD2

Prostate epithelial-specific expression of activated PI3K drives stromal collagen production and accumulation.


MeSH Terms

  • Aging
  • Animals
  • Class I Phosphatidylinositol 3-Kinases
  • Collagen
  • Disease Models, Animal
  • Disease Progression
  • Epithelium
  • Male
  • Mice, Mutant Strains
  • Phosphorylation
  • Prostate
  • Prostatic Hyperplasia
  • Prostatic Intraepithelial Neoplasia
  • Prostatic Neoplasms
  • Signal Transduction
  • Smad2 Protein
  • Stromal Cells
  • Transforming Growth Factor beta

Keywords

  • PIK3CA
  • cancer
  • collagen
  • fibrosis
  • mouse model
  • prostate
  • stroma

SMAD3

Sirtuin 6 deficiency transcriptionally up-regulates TGF-β signaling and induces fibrosis in mice.


MeSH Terms

  • Aging
  • Animals
  • Fibroblasts
  • Fibrosis
  • Gene Deletion
  • Male
  • Mice
  • Myocardium
  • Myofibroblasts
  • Signal Transduction
  • Sirtuins
  • Smad3 Protein
  • Transcriptional Activation
  • Transforming Growth Factor beta

Keywords

  • SIRT6 deacetylase
  • SMAD transcription factor
  • SMAD3
  • TGF-beta signaling
  • aging
  • aging-associated fibrosis
  • caloric restriction
  • cardiac disease
  • extracellular matrix (ECM)
  • fibrosis
  • sirtuin
  • transforming growth factor beta (TGF-beta)

SMN2

Age-dependent SMN expression in disease-relevant tissue and implications for SMA treatment.


MeSH Terms

  • Aging
  • Autopsy
  • Cell Survival
  • Female
  • Humans
  • Male
  • Motor Neurons
  • Muscular Atrophy, Spinal
  • Oligodeoxyribonucleotides, Antisense
  • Spinal Cord
  • Survival of Motor Neuron 2 Protein

Keywords

  • Development
  • Neurodegeneration
  • Neurodevelopment
  • Neuromuscular disease
  • Neuroscience

SMS

Does a Live Performance Impact Synchronization to Musical Rhythm in Cognitively Impaired Elderly?


Keywords

  • Aging
  • Alzheimer’s disease
  • cognitive impairment
  • dementia
  • motor activity
  • music therapy
  • social interaction


Testing the effectiveness of physical activity advice delivered via text messaging vs. human phone advisors in a Latino population: The On The Move randomized controlled trial design and methods.


Keywords

  • Aging
  • Digital health
  • Latino
  • Physical activity
  • Text-messaging
  • mHealth

SNAP25

The Biological Foundations of Sarcopenia: Established and Promising Markers.


Keywords

  • SNAP25
  • aging
  • biomarkers
  • neuromuscular junction
  • sarcopenia

SNCA

Behavioural and dopaminergic changes in double mutated human A30P*A53T alpha-synuclein transgenic mouse model of Parkinson´s disease.


MeSH Terms

  • Aging
  • Alanine
  • Amino Acid Substitution
  • Animals
  • Behavior, Animal
  • Disease Models, Animal
  • Dopaminergic Neurons
  • Humans
  • Locomotion
  • Male
  • Mice
  • Mice, Inbred C57BL
  • Mice, Transgenic
  • Mutation, Missense
  • Parkinson Disease
  • Proline
  • Threonine
  • alpha-Synuclein

SND1

[Downregulation of SND1 Expression Accelerates Cell Senescence of Human Diploid Fibroblasts 2BS via Modulating the SASP].


MeSH Terms

  • Cellular Senescence
  • Diploidy
  • Down-Regulation
  • Endonucleases
  • Fibroblasts
  • Humans
  • Nuclear Proteins

Keywords

  • Aging
  • Cellular senescent
  • SND1
  • Senescence-associated-secretory-phenotype

SOD1

SOD1, more than just an antioxidant.


Keywords

  • Aging
  • Cancer
  • Neurodegenerative diseases
  • Post-translational modifications
  • Superoxide dismutase 1


The Exacerbation of Aging and Oxidative Stress in the Epididymis of [i]Sod1[/i] Null Mice.


Keywords

  • 4-hydroxynonenal
  • 8-hydroxyguanosine
  • aging
  • epididymis
  • oxidative stress
  • reactive oxygen species
  • spermatozoa
  • superoxide dismutase


Alterations in lipid metabolism of spinal cord linked to amyotrophic lateral sclerosis.


MeSH Terms

  • Aging
  • Amyotrophic Lateral Sclerosis
  • Animals
  • Cardiolipins
  • Cholesterol Esters
  • Disease Models, Animal
  • Disease Progression
  • Fatty Acids, Unsaturated
  • Female
  • Humans
  • Lipid Droplets
  • Lipid Metabolism
  • Lipidomics
  • Male
  • Mass Spectrometry
  • Motor Cortex
  • Motor Neurons
  • Mutation
  • Oxidative Stress
  • Rats
  • Rats, Transgenic
  • Spinal Cord
  • Superoxide Dismutase-1

SOD2

Astaxanthin Counteracts Vascular Calcification In Vitro Through an Early Up-Regulation of SOD2 Based on a Transcriptomic Approach.


Keywords

  • aortic calcification
  • astaxanthin
  • chronic kidney disease
  • chronic kidney disease-mineral bone disorder
  • oxidative stress
  • reactive oxygen species
  • senescence
  • vascular calcification
  • vascular smooth muscle cells


Alginate Oligosaccharide Prevents against D-galactose-mediated Cataract in C57BL/6J Mice via Regulating Oxidative Stress and Antioxidant System.


Keywords

  • Cataract
  • D-galactose
  • aging
  • alginate oligosaccharide
  • oxidative stress


Protoflavones in melanoma therapy: Prooxidant and pro-senescence effect of protoapigenone and its synthetic alkyl derivative in A375 cells.


MeSH Terms

  • Antineoplastic Agents, Phytogenic
  • Autophagy
  • Biomarkers
  • Cell Cycle
  • Cell Line, Tumor
  • Cellular Senescence
  • Cyclohexanones
  • Flavones
  • Humans
  • Melanoma
  • Reactive Oxygen Species
  • Superoxide Dismutase
  • beta-Galactosidase

Keywords

  • Alkyl protoflavone
  • Flavonoid
  • Melanoma
  • Protoapigenone
  • Semi-synthesis
  • Senescence


Ginsenoside Rg1 protects against Sca-1 HSC/HPC cell aging by regulating the SIRT1-FOXO3 and SIRT3-SOD2 signaling pathways in a γ-ray irradiation-induced aging mice model.


Keywords

  • SIRT1
  • SIRT3
  • aging
  • ginsenoside Rg1
  • hematopoietic progenitor cells
  • hematopoietic stem cells
  • senescence
  • γ-ray irradiation


Almond Skin Extracts and Chlorogenic Acid Delay Chronological Aging and Enhanced Oxidative Stress Response in Yeast.


Keywords

  • 8-Oxo-guanine
  • aging
  • almond
  • chlorogenic acid
  • lipid peroxidation
  • mitochondria
  • oxidative stress
  • protein carbonylation
  • sirtuin
  • superoxide dismutase
  • yeast


Opposing p53 and mTOR/AKT promote an in vivo switch from apoptosis to senescence upon telomere shortening in zebrafish.


Keywords

  • AKT
  • aging
  • apoptosis
  • cell biology
  • p53
  • regenerative medicine
  • senescence
  • stem cells
  • telomeres
  • zebrafish


Bioactive peptides derived from crimson snapper and in vivo anti-aging effects on fat diet-induced high fat Drosophila melanogaster.


MeSH Terms

  • Aging
  • Animal Scales
  • Animals
  • Catalase
  • Diet, High-Fat
  • Disease Models, Animal
  • Drosophila Proteins
  • Drosophila melanogaster
  • Female
  • Fish Proteins
  • Fishes
  • Humans
  • Longevity
  • Male
  • Malondialdehyde
  • Oxidative Stress
  • Peptides
  • Superoxide Dismutase


Ellagic acid prolongs the lifespan of Drosophila melanogaster.


Keywords

  • Drosophila melanogaster
  • Ellagic acid
  • Gene expression
  • Longevity
  • Stress


Chlorella vulgaris modulates the expression of senescence-associated genes in replicative senescence of human diploid fibroblasts.


MeSH Terms

  • Antioxidants
  • Catalase
  • Cell Differentiation
  • Cell Proliferation
  • Cells, Cultured
  • Cellular Senescence
  • Chlorella vulgaris
  • DNA Damage
  • Diploidy
  • Fibroblasts
  • Gene Expression
  • Genes, p53
  • Humans
  • Male
  • Mitogen-Activated Protein Kinase 14
  • Molecular Chaperones
  • Primary Cell Culture
  • Signal Transduction
  • Superoxide Dismutase
  • Superoxide Dismutase-1

Keywords

  • Chlorella vulgaris
  • Fibroblasts
  • Replicative senescence
  • Senescence-associated genes


Age-Associated Changes in Antioxidants and Redox Proteins of Rat Heart.


MeSH Terms

  • Aging
  • Animals
  • Antioxidants
  • Glutathione Peroxidase
  • Male
  • Myocardium
  • Oxidation-Reduction
  • Rats
  • Rats, Wistar
  • Superoxide Dismutase


Impact of curcumin on replicative and chronological aging in the Saccharomyces cerevisiae yeast.


Keywords

  • Aging
  • Curcumin
  • Hypertrophy
  • Oxidative stress
  • Yeast

SOX13

In silico analysis of human renin gene-gene interactions and neighborhood topologically associated domains suggests breakdown of insulators contribute to ageing-associated diseases.


MeSH Terms

  • Aging
  • Computer Simulation
  • Epistasis, Genetic
  • Humans
  • Promoter Regions, Genetic
  • Renin

Keywords

  • Aging
  • Diseases of aging
  • Gene expression
  • Gene–gene interaction
  • Genomics
  • Longevity
  • Renin-angiotensin system
  • Topologically associated domains

SOX2

Multiple nanosecond pulsed electric fields stimulation with conductive poly(l-lactic acid)/carbon nanotubes films maintains the multipotency of mesenchymal stem cells during prolonged in vitro culture.


Keywords

  • cell physical stimulus
  • differentiation
  • mesenchymal stem cells
  • multipotency
  • nanosecond pulsed electric fields
  • senescence


Subpopulations of miniature pig mesenchymal stromal cells with different differentiation potentials differ in the expression of octamer-binding transcription factor 4 and sex determining region Y-box 2.


Keywords

  • Aging
  • Mesenchymal Stromal Cell (MSC) Subpopulations
  • Miniature Pig
  • Octamerbinding Transcription Factor 4 (OCT4)
  • Sex Determining Region Y-box 2 (SOX2)


Increased Type I and Decreased Type II Hair Cells after Deletion of Sox2 in the Developing Mouse Utricle.


MeSH Terms

  • Aging
  • Animals
  • Cell Count
  • Cell Differentiation
  • Cell Lineage
  • Hair Cells, Vestibular
  • Mice
  • Mice, Knockout
  • Mice, Transgenic
  • SOXB1 Transcription Factors
  • Saccule and Utricle

Keywords

  • SOX2
  • balance disorder
  • hair cell
  • utricle
  • vestibule

SOX4

Age-induced accumulation of methylmalonic acid promotes tumour progression.


MeSH Terms

  • Adult
  • Aged
  • Aging
  • Animals
  • Cell Line, Tumor
  • Disease Progression
  • Female
  • Gene Expression Regulation, Neoplastic
  • Humans
  • Male
  • Methylmalonic Acid
  • Mice
  • Middle Aged
  • Neoplasm Invasiveness
  • Neoplasm Metastasis
  • Neoplasms
  • SOXC Transcription Factors
  • Signal Transduction
  • Transcriptome
  • Transforming Growth Factor beta

SOX9

Positive Effects of a Young Systemic Environment and High Growth Differentiation Factor 11 Levels on Chondrocyte Proliferation and Cartilage Matrix Synthesis in Old Mice.


MeSH Terms

  • Adolescent
  • Aged
  • Aging
  • Animals
  • Arthroplasty, Replacement, Knee
  • Bone Morphogenetic Proteins
  • Cartilage, Articular
  • Cell Proliferation
  • Chondrocytes
  • Collagen Type II
  • Collagen Type X
  • Core Binding Factor Alpha 1 Subunit
  • Extracellular Matrix
  • Female
  • Growth Differentiation Factors
  • Humans
  • In Vitro Techniques
  • Knee Joint
  • Male
  • Matrix Metalloproteinase 13
  • Mice
  • Osteoarthritis, Knee
  • Parabiosis
  • Phosphorylation
  • RNA, Messenger
  • Reverse Transcriptase Polymerase Chain Reaction
  • SOX9 Transcription Factor
  • Smad2 Protein
  • Smad3 Protein
  • Stifle
  • Young Adult

SPARC

SPARC Metrics Provide Mobility Smoothness Assessment in Oldest-Old With and Without a History of Falls: A Case Control Study.


Keywords

  • aging
  • falls
  • functional mobility
  • movement smoothness
  • oldest-old


Reduced fibrillar collagen accumulation in skeletal muscle of secreted protein acidic and rich in cysteine (SPARC)-null mice.


MeSH Terms

  • Aging
  • Animals
  • Fibrillar Collagens
  • Gene Expression
  • Male
  • Mice
  • Mice, Knockout
  • Muscle, Skeletal
  • Myofibrils
  • Osteonectin

Keywords

  • Secreted protein acidic and rich in cysteine
  • collagen
  • fibrosis
  • myofiber
  • skeletal muscle

SPR

Regulation of lifespan by neural excitation and REST.


MeSH Terms

  • Aging
  • Animals
  • Brain
  • Caenorhabditis elegans
  • Caenorhabditis elegans Proteins
  • DNA-Binding Proteins
  • Forkhead Transcription Factors
  • Humans
  • Longevity
  • Mice
  • Mice, 129 Strain
  • Mice, Inbred C57BL
  • Mice, Knockout
  • Mice, Transgenic
  • Neurons
  • RNA Interference
  • RNA-Binding Proteins
  • Repressor Proteins
  • Transcription Factors

SPRTN

Tandem Deubiquitination and Acetylation of SPRTN Promotes DNA-Protein Crosslink Repair and Protects against Aging.


MeSH Terms

  • Acetylation
  • Aging
  • Animals
  • Cell Line
  • DNA Damage
  • DNA Repair
  • DNA-Binding Proteins
  • Deubiquitinating Enzymes
  • Endopeptidases
  • Female
  • Genomic Instability
  • HEK293 Cells
  • Humans
  • Male
  • Mice, Inbred C57BL
  • Mice, Knockout
  • Phosphorylation
  • Protein Domains
  • Protein Processing, Post-Translational
  • Ubiquitination

Keywords

  • DNA repair
  • DNA-protein crosslink
  • SPRTN
  • Top1cc
  • VCPIP1/VCIP135
  • acetylation
  • aging
  • genomic instability
  • metalloprotease
  • ubiquitination

SPRY1

Sprouty1 Prevents Cellular Senescence Maintaining Proliferation and Differentiation Capacity of Human Adipose Stem/Progenitor Cells.


Keywords

  • Adipogenesis
  • Adipose stem cell
  • Obesity
  • Senescence
  • Sprouty1


Mechanism of SPRY1 methylation regulating natural aging of skin epidermal cells.


Keywords

  • SPRY1
  • methylation
  • natural aging
  • skin epidermal aging

SQSTM1

The selective autophagy receptor SQSTM1/p62 improves lifespan and proteostasis in an evolutionarily conserved manner.


Keywords

  • Aging
  • C. elegans
  • Drosophila
  • SQST-1
  • SQSTM1
  • aggrephagy
  • heat shock
  • mitophagy
  • p62
  • proteostasis
  • ref(2)P
  • selective autophagy

SRC

Metabolic characteristics of CD8 T cell subsets in young and aged individuals are not predictive of functionality.


MeSH Terms

  • Adult
  • Aged
  • Aging
  • Animals
  • CD8-Positive T-Lymphocytes
  • Cell Differentiation
  • Cell Proliferation
  • Disease Models, Animal
  • Female
  • Humans
  • Immunologic Memory
  • Influenza A virus
  • Influenza, Human
  • Male
  • Mice
  • Microscopy, Electron, Transmission
  • Mitochondria
  • T-Lymphocyte Subsets
  • Young Adult

SRD5A2

Extract of Plumbago zeylanica enhances the growth of hair follicle dermal papilla cells with down-regulation of 5α-reductase type II.


Keywords

P zeylanica

  • 5α-reductase
  • dermal papilla
  • hair
  • plumbagin
  • senescence

SRF

Changes in snail and SRF expression in the kidneys of diabetic rats during ageing.


MeSH Terms

  • Aging
  • Animals
  • Diabetes Mellitus, Experimental
  • Diabetic Nephropathies
  • Gene Expression Regulation
  • Kidney
  • Male
  • Rats
  • Rats, Sprague-Dawley
  • Snail Family Transcription Factors
  • Transcription Factors

Keywords

  • Diabetic nephropathy
  • Renal fibrosis
  • SRF
  • Snail


Mechanosensitive transcriptional coactivators MRTF-A and YAP/TAZ regulate nucleus pulposus cell phenotype through cell shape.


MeSH Terms

  • Actins
  • Adaptor Proteins, Signal Transducing
  • Aging
  • Biomechanical Phenomena
  • Cells, Cultured
  • Cytoskeleton
  • Gene Expression Regulation
  • Humans
  • Hydrogels
  • Intervertebral Disc Degeneration
  • Nucleus Pulposus
  • RNA Interference
  • Trans-Activators
  • Transcription Factors
  • rho-Associated Kinases

Keywords

  • F-actin
  • SRF
  • TEAD
  • intervertebral disc
  • mechanotransduction

SRL

Income dividends and subjective survival in a Cherokee Indian cohort: a quasi-experiment.


MeSH Terms

  • Adult
  • Aged
  • Aged, 80 and over
  • Cohort Studies
  • Female
  • Humans
  • Income
  • Indians, South American
  • Longevity
  • Male
  • Middle Aged
  • North Carolina
  • Social Class
  • Surveys and Questionnaires
  • Survival Analysis

SRM

[Geriatric specificities of localized renal cell carcinoma].


MeSH Terms

  • Age Factors
  • Aged
  • Carcinoma, Renal Cell
  • Geriatric Assessment
  • Humans
  • Kidney Neoplasms

Keywords

  • Cancer du rein
  • Diagnosis
  • Diagnostic
  • Elderly
  • Geriatrics
  • Gériatrie
  • Personne âgée
  • Petite masse rénale
  • Renal cell carcinoma
  • Small renal mass
  • Traitement
  • Treatment

SSB

Modelling the Effects of Beverage Substitution during Adolescence on Later Obesity Outcomes in Early Adulthood: Results from the Raine Study.


MeSH Terms

  • Adolescent
  • Adolescent Nutritional Physiological Phenomena
  • Aging
  • Humans
  • Models, Biological
  • Obesity
  • Odds Ratio
  • Risk Factors
  • Sugar-Sweetened Beverages
  • Young Adult

Keywords

  • obesity
  • substitution modelling
  • sugar-sweetened beverages
  • waist circumference

SST

The distance to death perceptions of older adults explain why they age in place: A theoretical examination.


Keywords

  • Agency- or belonging-related
  • Distance to death, aging in place
  • Emotions
  • Residential mobility
  • Socioemotional selectivity theory


Population Segmentation Based on Healthcare Needs: Validation of a Brief Clinician-Administered Tool.


Keywords

  • aging
  • health services research
  • psychometrics


Examination on how emotion regulation mediates the relationship between future time perspective and well-being: a counter-evidence to the socioemotional selectivity theory.


Keywords

  • Aging
  • Emotion regulation
  • Future time perspective
  • Socioemotional selectivity theory
  • Time left in life

STAT1

STAT1-p53-p21axis-dependent stress-induced progression of chronic nephrosis in adriamycin-induced mouse model.


Keywords

  • Adriamycin
  • STAT1
  • chronic nephrosis (CN)
  • mitogen-activated protein kinase
  • senescence


Age-Dependent and -Independent Effects of Perivascular Adipose Tissue and Its Paracrine Activities during Neointima Formation.


MeSH Terms

  • Adipose Tissue
  • Aging
  • Animals
  • Carotid Arteries
  • Carotid Artery Diseases
  • Carotid Artery Injuries
  • Humans
  • Mice
  • Mice, Mutant Strains
  • Neointima
  • Paracrine Communication
  • STAT1 Transcription Factor

Keywords

  • aging
  • atherosclerosis
  • neointima formation
  • perivascular adipose tissue


Legumain-deficient macrophages promote senescence of tumor cells by sustaining JAK1/STAT1 activation.


MeSH Terms

  • Animals
  • Bone Marrow Transplantation
  • Breast Neoplasms
  • Cell Cycle Proteins
  • Cell Line, Tumor
  • Cellular Senescence
  • Disease Models, Animal
  • Female
  • Gene Expression Regulation, Neoplastic
  • Humans
  • Integrin alphaVbeta3
  • Interleukin-1beta
  • Janus Kinase 1
  • Macrophage Activation
  • Macrophages
  • Mice
  • Mice, Knockout
  • STAT1 Transcription Factor
  • Signal Transduction

Keywords

  • Cellular senescence
  • Legumain
  • M1 polarization
  • Tumor-associated macrophage

STAT3

Dietary Restriction Suppresses Steatosis-Associated Hepatic Tumorigenesis in Hepatitis C Virus Core Gene Transgenic Mice.


Keywords

  • Cyclin D1
  • NF-κB
  • STAT3
  • Senescence
  • p62/SQSTM1


Skeletal glucocorticoid signalling determines leptin resistance and obesity in aging mice.


Keywords

  • Aging
  • Appetite
  • Glucocorticoid
  • Leptin
  • Obesity
  • Osteoblast
  • Osteocyte


AMPK alleviates oxidative stress‑induced premature senescence via inhibition of NF-κB/STAT3 axis-mediated positive feedback loop.


Keywords

  • AMPK
  • NF-κB/STAT3 signalling
  • Oxidative stress
  • SASP
  • Senescence


Age-related loss of neural stem cell O-GlcNAc promotes a glial fate switch through STAT3 activation.


MeSH Terms

  • Aging
  • Animals
  • Cell Differentiation
  • Cell Proliferation
  • Computational Biology
  • Gene Expression Regulation
  • Glucosamine
  • Hippocampus
  • Mice
  • Neural Stem Cells
  • Neurogenesis
  • Neuroglia
  • STAT3 Transcription Factor
  • Sequence Analysis, RNA

Keywords

  • O-GlcNAcylation
  • aging
  • gliogenesis
  • neural stem cells
  • neurogenesis


Cell Death by Gallotannin Is Associated with Inhibition of the JAK/STAT Pathway in Human Colon Cancer Cells.


Keywords

  • Apoptosis
  • JAK/STAT
  • caspase
  • colon cancer
  • gallotannin
  • senescence


The effect of interleukin 6 deficiency on myocardial signal transduction pathways activation induced by bacterial lipopolysaccharide in young and old mice.


Keywords

  • Aging
  • For review: bacterial lipolisacharide (LPS)
  • Heart
  • Inflammation
  • Interleukin-6
  • Signal transduction


Silibinin and SARS-CoV-2: Dual Targeting of Host Cytokine Storm and Virus Replication Machinery for Clinical Management of COVID-19 Patients.


Keywords

  • IL-6
  • JAK
  • coronavirus
  • cytokine storm
  • remdesivir
  • senescence
  • stat3


Implication of JAK1/STAT3/SOCS3 Pathway in Aging of Cerebellum of Male Rat: Histological and Molecular study.


MeSH Terms

  • Aging
  • Animals
  • Caspase 3
  • Cerebellum
  • Glial Fibrillary Acidic Protein
  • Glutathione
  • Immunohistochemistry
  • Janus Kinase 1
  • Male
  • Malondialdehyde
  • Microscopy, Electron
  • Rats
  • Rats, Wistar
  • STAT3 Transcription Factor
  • Signal Transduction
  • Suppressor of Cytokine Signaling 3 Protein
  • Tumor Necrosis Factor-alpha


Atorvastatin-induced senescence of hepatocellular carcinoma is mediated by downregulation of hTERT through the suppression of the IL-6/STAT3 pathway.


Keywords

  • Cancer therapy
  • Senescence


Deciphering the Molecular Mechanism of Spontaneous Senescence in Primary Epithelial Ovarian Cancer Cells.


Keywords

  • aging biomarkers
  • cancer biology
  • cellular senescence
  • epithelial ovarian cancer
  • oxidative stress


Persistent Activation of STAT3 Pathway in the Retina Induced Vision Impairment and Retinal Degenerative Changes in Ageing Mice.


MeSH Terms

  • Aging
  • Animals
  • Mice
  • Mice, Inbred C57BL
  • Retina
  • Retinal Degeneration
  • STAT3 Transcription Factor
  • Suppressor of Cytokine Signaling 3 Protein
  • Suppressor of Cytokine Signaling Proteins
  • Uveitis

Keywords

  • EAU
  • Experimental autoimmune uveitis
  • Retinal dystrophies
  • SOCS3
  • STAT3
  • Transgenic mouse
  • Uveitis


Interleukin-10 induces senescence of activated hepatic stellate cells via STAT3-p53 pathway to attenuate liver fibrosis.


Keywords

  • Hepatic stellate cells
  • Interleukin-10
  • Liver fibrosis
  • Senescence
  • Signal pathway

STC2

Genome-wide Associations Reveal Human-Mouse Genetic Convergence and Modifiers of Myogenesis, CPNE1 and STC2.


MeSH Terms

  • Adult
  • Aged
  • Aging
  • Animals
  • Body Composition
  • Body Weight
  • Calcium-Binding Proteins
  • Case-Control Studies
  • Female
  • Follow-Up Studies
  • Genome-Wide Association Study
  • Glycoproteins
  • Humans
  • Intercellular Signaling Peptides and Proteins
  • Male
  • Mice
  • Middle Aged
  • Muscle Development
  • Muscle, Skeletal
  • Quantitative Trait Loci
  • Thinness

Keywords

  • UK Biobank
  • human and mouse GWAS
  • sarcopenia
  • skeletal muscle

STIM1

Progerin in muscle leads to thermogenic and metabolic defects via impaired calcium homeostasis.


MeSH Terms

  • Animals
  • Calcium
  • Calnexin
  • Cell Nucleus
  • Disease Models, Animal
  • Endoplasmic Reticulum
  • Endoplasmic Reticulum Stress
  • Lamin Type A
  • Mice
  • Mice, Knockout
  • Microscopy, Electron, Transmission
  • Muscle Proteins
  • Muscle, Skeletal
  • Muscular Dystrophies
  • Mutation
  • Myoblasts
  • ORAI1 Protein
  • Progeria
  • Proteolipids
  • Stromal Interaction Molecule 1
  • Thermogenesis
  • Up-Regulation

Keywords

  • aging
  • calcium homeostasis
  • lamin A
  • muscular dystrophy
  • progeria

STS

Delayed Impairment of Postural, Physical, and Muscular Functions Following Downhill Compared to Level Walking in Older People.


Keywords

  • aging
  • balance
  • falls
  • fatigue
  • functional performance
  • muscle damage
  • walking


Autophagy displays divergent roles during intermittent amino acid starvation and toxic stress-induced senescence in cultured skeletal muscle cells.


Keywords

  • autophagy
  • caspase
  • cell death
  • remodeling
  • senescence


The WRKY53 transcription factor enhances stilbene synthesis and disease resistance by interacting with MYB14 and MYB15 in Chinese wild grape.


Keywords

  • Chinese wild grape (Vitis quinquangularis)
  • WRKY transcription factor
  • disease resistance
  • leaf senescence
  • stilbene
  • transcriptional regulation


On the role of ageing and musculoskeletal pain on dynamic balance in manual workers.


MeSH Terms

  • Aged
  • Aging
  • Female
  • Humans
  • Male
  • Middle Aged
  • Muscle, Skeletal
  • Musculoskeletal Pain
  • Occupational Diseases
  • Postural Balance

Keywords

  • Discomfort
  • Lower extremity function
  • Posturography
  • Sit-to-stand

SUCNR1

[The effect of Mexidol on cerebral mitochondriogenesis at a young age and during aging].


MeSH Terms

  • Age Factors
  • Aging
  • Animals
  • Male
  • Mitochondria
  • Neurodegenerative Diseases
  • Picolines
  • Rats
  • Receptors, G-Protein-Coupled
  • Transcription Factors

Keywords

  • Western blot analysis
  • aging
  • cerebral mitochondriogenesis
  • mexidol
  • mitochondrial dysfunction
  • rats
  • respiratory enzyme subunits
  • succinate receptor
  • transcriptional coactivator PGC-1α

SUGCT

Knockout of the non-essential gene SUGCT creates diet-linked, age-related microbiome disbalance with a diabetes-like metabolic syndrome phenotype.


MeSH Terms

  • Aging
  • Animals
  • Anti-Bacterial Agents
  • Bacteria
  • Carnitine
  • Coenzyme A-Transferases
  • Dietary Supplements
  • Feces
  • Gastrointestinal Microbiome
  • Humans
  • Kidney
  • Lipid Metabolism
  • Liver
  • Lysine
  • Metabolic Syndrome
  • Metabolome
  • Mice
  • Mice, Knockout
  • Obesity
  • Tryptophan

Keywords

  • C7orf10
  • Glutaric aciduria type 3 (GA3)
  • Gut microflora
  • Lipids
  • Metabolomics
  • Obesity
  • Sugct

SUV39H1

Increase in hippocampal histone H3K9me3 is negatively correlated with memory in old male mice.


Keywords

  • Aging
  • H3K9me3
  • Hippocampus
  • IEGs
  • Memory
  • SUV39H1

SYK

miR-25-3p promotes endothelial cell angiogenesis in aging mice via TULA-2/SYK/VEGFR-2 downregulation.


Keywords

  • TULA-2
  • aging
  • angiogenesis
  • endothelial cell
  • miR-25-3p


Identification of SYK inhibitor, R406 as a novel senolytic agent.


Keywords

  • FAK
  • apoptosis
  • cellular senescence
  • p38
  • senolytics

SYNE1

Nesprin-1 impact on tumorigenic cell phenotypes.


MeSH Terms

  • Actins
  • Carcinogenesis
  • Cell Line, Tumor
  • Cell Nucleus
  • Cytoskeletal Proteins
  • Gene Expression
  • Gene Expression Regulation, Neoplastic
  • Humans
  • Microfilament Proteins
  • Nerve Tissue Proteins
  • Nuclear Envelope
  • Phenotype

Keywords

  • Cancer
  • Cellular senescence
  • Genome stability
  • Nesprin-1
  • Nuclear envelope

TAAR1

Minimal Age-Related Alterations in Behavioral and Hematological Parameters in Trace Amine-Associated Receptor 1 (TAAR1) Knockout Mice.


MeSH Terms

  • Age Factors
  • Animals
  • Anxiety
  • Dose-Response Relationship, Drug
  • Male
  • Mice
  • Mice, 129 Strain
  • Mice, Inbred C57BL
  • Mice, Knockout
  • Receptors, G-Protein-Coupled
  • Sodium Chloride

Keywords

  • Aging
  • Anxiety
  • Hematology
  • Leukocytes
  • Neutrophils
  • TAAR1
  • Thyroid
  • Trace amines

TAS2R16

Taste receptor polymorphisms and longevity: a systematic review and meta-analysis.


Keywords

  • Immune-inflammatory responses
  • Longevity
  • Meta-analysis
  • Taste receptors

TAS2R38

TAS2R38 bitter taste receptor and attainment of exceptional longevity.


MeSH Terms

  • Adolescent
  • Adult
  • Aged
  • Aged, 80 and over
  • Case-Control Studies
  • Female
  • Food Preferences
  • Gene Frequency
  • Genetic Variation
  • Haplotypes
  • Humans
  • Longevity
  • Male
  • Middle Aged
  • Receptors, G-Protein-Coupled
  • Taste
  • Taste Perception
  • Young Adult

TAZ

Transcriptional Coactivator TAZ Negatively Regulates Tumor Suppressor p53 Activity and Cellular Senescence.


Keywords

  • TAZ
  • cellular senescence
  • oncogene
  • p300
  • p53

TBC1D5

TBC1D5-Catalyzed Cycling of Rab7 Is Required for Retromer-Mediated Human Papillomavirus Trafficking during Virus Entry.


Keywords

  • HPV
  • Rab7B
  • TBC1D5
  • functional genetics screen
  • proximity ligation assay
  • retrograde
  • retromer
  • senescence
  • traptamer


Retromer and TBC1D5 maintain late endosomal RAB7 domains to enable amino acid-induced mTORC1 signaling.


MeSH Terms

  • Animals
  • Caenorhabditis elegans
  • Caenorhabditis elegans Proteins
  • Longevity
  • Mechanistic Target of Rapamycin Complex 1
  • Membrane Microdomains
  • Signal Transduction
  • rab GTP-Binding Proteins

TBK1

Parkin overexpression alleviates cardiac aging through facilitating K63-polyubiquitination of TBK1 to facilitate mitophagy.


Keywords

  • Aging
  • K63-linked polyubiquitination
  • Mitophagy
  • Parkin
  • TBK1

TCF7L2

A myelin-related transcriptomic profile is shared by Pitt-Hopkins syndrome models and human autism spectrum disorder.


MeSH Terms

  • Aging
  • Animals
  • Autism Spectrum Disorder
  • Cell Count
  • DNA Fingerprinting
  • Facies
  • Gene Expression Regulation
  • Humans
  • Hyperventilation
  • Intellectual Disability
  • Methyl-CpG-Binding Protein 2
  • Mice
  • Mice, Knockout
  • Myelin Sheath
  • Oligodendroglia
  • PTEN Phosphohydrolase
  • Primary Cell Culture
  • Signal Transduction
  • Transcription Factor 4
  • Transcriptome

TEC

Vestibular function and cortical and sub-cortical alterations in an aging population.


Keywords

  • Aging
  • Cognition
  • Diffeomorphometry
  • Epidemiology
  • Eye-ear-nose-throat
  • MRI
  • Medical imaging
  • Shape
  • Vestibular
  • Volume


Metabolic Flexibility and Innate Immunity in Renal Ischemia Reperfusion Injury: The Fine Balance Between Adaptive Repair and Tissue Degeneration.


Keywords

  • cell death
  • innate immunity
  • kidney transplantation
  • mitochondria
  • senescence
  • tubular repair


Postnatal Involution and Counter-Involution of the Thymus.


Keywords

  • Myc
  • aging
  • cyclin D1
  • growth
  • involution
  • thymus


Gender Disparity Impacts on Thymus Aging and LHRH Receptor Antagonist-Induced Thymic Reconstitution Following Chemotherapeutic Damage.


Keywords

  • aging
  • chemotherapy
  • gender
  • luteinizing hormone-releasing hormone
  • regeneration
  • sex hormone deprivation
  • thymic epithelial cell
  • thymus


Clonogenic Culture of Mouse Thymic Epithelial Cells.


MeSH Terms

  • Aging
  • Animals
  • Cell Differentiation
  • Cell Line
  • Coculture Techniques
  • Colony-Forming Units Assay
  • DNA-Binding Proteins
  • Epithelial Cells
  • Flow Cytometry
  • Fluorescent Antibody Technique, Direct
  • Fluorescent Dyes
  • Immunomagnetic Separation
  • Mice
  • Mice, Knockout
  • Primary Cell Culture
  • Rhodamines
  • Self Tolerance
  • Staining and Labeling
  • Stem Cells
  • Thymus Gland

Keywords

  • Clonogenic assay
  • Thymic epithelial cells
  • Thymic epithelial stem cells
  • Thymus

TEF

Expression of human HSP27 in yeast extends replicative lifespan and uncovers a hormetic response.


Keywords

  • Aging
  • Cancer
  • HSP27
  • Hormesis
  • Neurodegeneratve diseases
  • Proteasome

TERT

Telomeres and telomerase in risk assessment of cardiovascular diseases.


Keywords

  • Cardiovascular diseases
  • Senescence
  • Telomerase
  • Telomeres


A 4-Base-Pair Core-Enclosing Helix in Telomerase RNA Is Essential for Activity and for Binding to the Telomerase Reverse Transcriptase Catalytic Protein Subunit.


Keywords

  • RNA
  • RNP
  • TERT
  • TLC1
  • senescence
  • telomerase
  • telomerase RNA
  • telomere
  • two-hybrid screening
  • yeast


Angiotensin inhibition and cellular senescence in the developing rat kidney.


Keywords

  • Apoptosis
  • Cellular senescence
  • Fetal development
  • Kidney
  • Renin-angiotensin system


Decreased expression of TERT and telomeric proteins as human ovaries age may cause telomere shortening.


Keywords

  • Ovarian aging
  • TERT
  • Telomere
  • Telomere-binding proteins


The secrets of telomerase: Retrospective analysis and future prospects.


MeSH Terms

  • Aging
  • Animals
  • Diabetes Mellitus
  • Humans
  • Neoplasms
  • Telomerase
  • Telomere Shortening

Keywords

  • Cancers
  • G-quadruplex formation
  • Metabolic disorders
  • TERT gene
  • Telomere-telomerase system


Gene expression in human mesenchymal stem cell aging cultures: modulation by short peptides.


Keywords

  • Cell aging
  • Genes
  • Human mesenchymal stem cells
  • Short peptides


Unravelling Cellular Mechanisms of Stem Cell Senescence: An Aid from Natural Bioactive Molecules.


Keywords

  • cellular mechanisms
  • gene expression
  • nutraceuticals
  • oxidative stress
  • senescence
  • stem cells


Expression of telomerase reverse transcriptase positively correlates with duration of lithium treatment in bipolar disorder.


MeSH Terms

  • Adult
  • Aging
  • Antimanic Agents
  • Bipolar Disorder
  • Cellular Senescence
  • Female
  • Humans
  • Lithium
  • Lithium Compounds
  • Male
  • Middle Aged
  • Mitochondria
  • Oxidative Stress
  • Polymorphism, Single Nucleotide
  • Real-Time Polymerase Chain Reaction
  • Telomerase
  • Telomere
  • Telomere Homeostasis
  • Telomere Shortening

Keywords

  • Affective disorder
  • Aging
  • Mitochondria
  • Oxidative stress
  • TERT
  • Telomere


FAM96B inhibits the senescence of dental pulp stem cells.


Keywords

  • FAM96B
  • aging
  • dental pulp stem cells (DPSCs)
  • proteomic analysis


Aging and biomarkers: Transcriptional levels evaluation of Osteopontin/miRNA-181a axis in hepatic tissue of rats in different age ranges.


Keywords

  • Aging
  • Long non-coding RNA
  • Osteopontin
  • Telomeres
  • miRNA


Resveratrol inhibits adipocyte differentiation and cellular senescence of human bone marrow stromal stem cells.


Keywords

  • Adipogenesis
  • Antioxidant
  • Bone marrow adiposity
  • Bone marrow skeletal stromal cells
  • Cellular senescence
  • Osteogenesis


Characterization of human telomerase reverse transcriptase immortalized anterior cruciate ligament cell lines.


MeSH Terms

  • Adolescent
  • Aged
  • Anterior Cruciate Ligament
  • Cell Differentiation
  • Cell Separation
  • Cells, Cultured
  • Humans
  • Mesenchymal Stem Cells
  • Telomerase

Keywords

  • Anterior cruciate ligament
  • Immortalization
  • Mesenchymal stem cells
  • Multilineage differentiation
  • Senescence


Mitochondria, Telomeres and Telomerase Subunits.


Keywords

  • TERC
  • TERT
  • aging
  • mitochondria
  • telomerase
  • telomere


Towards Therapeutic Alternatives for Mercury Neurotoxicity in the Amazon: Unraveling the Pre-Clinical Effects of the Superfruit Açaí ([i]Euterpe oleracea[/i], Mart.) as Juice for Human Consumption.


MeSH Terms

  • Animals
  • Antioxidants
  • Behavior, Animal
  • Brain Chemistry
  • Euterpe
  • Fruit and Vegetable Juices
  • Lipid Peroxidation
  • Male
  • Mercury
  • Mice
  • Motor Skills
  • Neurotoxins
  • Plant Extracts
  • Telomere

Keywords

  • Euterpe
  • acai
  • aging
  • antioxidant
  • açaí
  • extract
  • intoxication
  • methylmercury
  • telomere


Replication Stress at Telomeric and Mitochondrial DNA: Common Origins and Consequences on Ageing.


MeSH Terms

  • Aging
  • Animals
  • Cellular Senescence
  • DNA Damage
  • DNA Replication
  • DNA, Mitochondrial
  • Epigenesis, Genetic
  • Humans
  • Mitochondria
  • Oxidative Stress
  • Stress, Physiological
  • Telomere
  • Telomere Homeostasis
  • Telomere Shortening

Keywords

  • G-quadruplex
  • R-loop
  • ageing
  • helicase
  • mitochondria
  • replication stress
  • senescence
  • telomere


Telomerase Biology Associations Offer Keys to Cancer and Aging Therapeutics.


Keywords

  • Aging
  • TERT
  • associates
  • cancer
  • cell cycle
  • diseases
  • oncogenes
  • viral infection.


Transient induction of telomerase expression mediates senescence and reduces tumorigenesis in primary fibroblasts.


MeSH Terms

  • Animals
  • Cell Cycle
  • Cell Transformation, Neoplastic
  • Cells, Cultured
  • Cellular Senescence
  • Fibroblasts
  • Gene Expression
  • Gene Expression Regulation
  • Gene Knockdown Techniques
  • Humans
  • Mice
  • Mice, Inbred C57BL
  • Mice, Knockout
  • Phenotype
  • Telomerase
  • Telomere

Keywords

  • ATM
  • senescence
  • telomerase
  • tumorigenesis

TET2

Non-coding and Loss-of-Function Coding Variants in TET2 are Associated with Multiple Neurodegenerative Diseases.


MeSH Terms

  • Aged
  • Aged, 80 and over
  • Alzheimer Disease
  • Animals
  • Cognition
  • DNA-Binding Proteins
  • Female
  • Frontotemporal Dementia
  • Humans
  • Loss of Function Mutation
  • Male
  • Mice
  • Neurodegenerative Diseases
  • Proto-Oncogene Proteins

Keywords

  • AD
  • ALS
  • Alzheimer
  • FTD
  • TET2
  • aging
  • amyotrophic lateral sclerosis
  • frontotemporal dementia
  • genome sequencing
  • non-coding


60 Years of clonal hematopoiesis research: From X-chromosome inactivation studies to the identification of driver mutations.


MeSH Terms

  • Adult
  • Aging
  • Biomedical Research
  • Chromosomes, Human, X
  • DNA-Binding Proteins
  • Female
  • Hematopoiesis
  • Hematopoietic Stem Cells
  • History, 20th Century
  • History, 21st Century
  • Humans
  • Male
  • Mutation
  • Proto-Oncogene Proteins
  • Receptors, Androgen
  • Repressor Proteins
  • X Chromosome Inactivation


DNA methylation instability by BRAF-mediated TET silencing and lifestyle-exposure divides colon cancer pathways.


MeSH Terms

  • Animals
  • Caco-2 Cells
  • Cell Line, Tumor
  • Colonic Neoplasms
  • DNA Methylation
  • DNA-Binding Proteins
  • Down-Regulation
  • Epigenesis, Genetic
  • Female
  • Gene Regulatory Networks
  • HT29 Cells
  • Humans
  • Male
  • Mice
  • Mixed Function Oxygenases
  • Mutation
  • Neoplasms, Experimental
  • Proto-Oncogene Proteins
  • Proto-Oncogene Proteins B-raf

Keywords

  • Aging
  • BRAF V600E
  • CIMP
  • Colon cancer
  • DNA methylation
  • TET


Clonal haematopoiesis: connecting ageing and inflammation in cardiovascular disease.


MeSH Terms

  • Adult
  • Age Factors
  • Aged
  • Aged, 80 and over
  • Aging
  • Animals
  • Cardiovascular Diseases
  • DNA (Cytosine-5-)-Methyltransferases
  • DNA-Binding Proteins
  • Genetic Predisposition to Disease
  • Hematopoiesis
  • Hematopoietic Stem Cells
  • Humans
  • Inflammation
  • Middle Aged
  • Mutation
  • Phenotype
  • Proto-Oncogene Proteins
  • Repressor Proteins
  • Risk Assessment
  • Risk Factors

TF

A preliminary investigation of the contribution of different tenderness factors to beef loin, tri-tip and heel tenderness.


Keywords

  • Aging
  • Beef
  • Collagen
  • Tenderness
  • Trained panel


The transcription factor ZmNAC126 accelerates leaf senescence downstream of the ethylene signalling pathway in maize.


Keywords

  • ZmNAC
  • chlorophyll catabolic genes
  • ethylene
  • leaf senescence
  • maize


Extensive transcriptome changes during seasonal leaf senescence in field-grown black cottonwood (Populus trichocarpa Nisqually-1).


MeSH Terms

  • Aging
  • Gene Expression Profiling
  • Gene Expression Regulation, Plant
  • Genome, Plant
  • Photosynthesis
  • Plant Leaves
  • Populus
  • Seasons
  • Transcription Factors
  • Transcriptome


Expression of Transferrin and Albumin in the Sperm-Storage Tubules of Japanese Quail and their Possible Involvement in Long-Term Sperm Storage.


Keywords

  • Japanese quail
  • albumin
  • sperm longevity
  • sperm storage tubules
  • transferrin


OsWRKY5 Promotes Rice Leaf Senescence via Senescence-Associated NAC and Abscisic Acid Biosynthesis Pathway.


MeSH Terms

  • Abscisic Acid
  • Chlorophyll
  • Gene Expression Regulation, Plant
  • Gene Knockdown Techniques
  • Oryza
  • Plant Leaves
  • Plant Proteins
  • Transcription Factors

Keywords

  • NAC
  • OsWRKY
  • abscisic acid (ABA)
  • leaf senescence
  • rice


BrTCP7 Transcription Factor Is Associated with MeJA-Promoted Leaf Senescence by Activating the Expression of [i]BrOPR3[/i] and [i]BrRCCR[/i].


MeSH Terms

  • Amino Acid Sequence
  • Brassica
  • Cellular Senescence
  • Cyclopentanes
  • Gene Expression Regulation, Plant
  • Oxylipins
  • Phenotype
  • Phylogeny
  • Plant Growth Regulators
  • Plant Leaves
  • Plant Proteins
  • Promoter Regions, Genetic
  • Protein Binding
  • Transcription Factors

Keywords

  • Chinese flowering cabbage
  • JA
  • leaf senescence
  • transcriptional activation


Activation of the Transcription of [i]BrGA20ox3[/i] by a BrTCP21 Transcription Factor Is Associated with Gibberellin-Delayed Leaf Senescence in Chinese Flowering Cabbage during Storage.


MeSH Terms

  • Aging
  • Base Sequence
  • Brassica
  • Food Preservation
  • Gene Expression Regulation, Plant
  • Gibberellins
  • Phenotype
  • Phylogeny
  • Plant Leaves
  • Plant Proteins
  • Promoter Regions, Genetic
  • Protein Binding
  • Transcription Factors

Keywords

  • Chinese flowering cabbage
  • GA
  • leaf senescence
  • transcriptional activation

TFEB

A Novel Lipofuscin-detecting Marker of Senescence Relates With Hypoxia, Dysregulated Autophagy and With Poor Prognosis in Non-small-cell-lung Cancer.


Keywords

  • Senescence
  • autophagy
  • glycolysis
  • hypoxia
  • lipofuscin
  • lung cancer


ESC-sEVs Rejuvenate Senescent Hippocampal NSCs by Activating Lysosomes to Improve Cognitive Dysfunction in Vascular Dementia.


Keywords

  • embryonic stem cells derived small extracellular vesicles (ESC‐sEVs)
  • hippocampal neural stem cells (HNSCs)
  • lysosomes
  • senescence
  • vascular dementia


Nitrative Stress-Related Autophagic Insufficiency Participates in Hyperhomocysteinemia-Induced Renal Aging.


MeSH Terms

  • Aging
  • Animals
  • Autophagy
  • Cells, Cultured
  • Homocysteine
  • Humans
  • Hyperhomocysteinemia
  • Kidney
  • Kidney Diseases
  • Male
  • Metalloporphyrins
  • Peroxynitrous Acid
  • Rats
  • Rats, Sprague-Dawley


Polyamines reverse immune senescence via the translational control of autophagy.


MeSH Terms

  • Aging
  • Animals
  • Autophagy
  • Humans
  • Lysosomes
  • Polyamines
  • Protein Processing, Post-Translational
  • Spermidine

Keywords

  • Aging
  • B cells
  • EIF5A
  • TFEB
  • autophagy
  • hypusine
  • spermidine
  • translation


Polyamines Control eIF5A Hypusination, TFEB Translation, and Autophagy to Reverse B Cell Senescence.


MeSH Terms

  • Adaptive Immunity
  • Age Factors
  • Aging
  • Animals
  • Autophagy
  • B-Lymphocytes
  • Basic Helix-Loop-Helix Leucine Zipper Transcription Factors
  • Cellular Senescence
  • HEK293 Cells
  • Humans
  • Immunologic Memory
  • Immunosenescence
  • Jurkat Cells
  • Mice
  • Mice, Inbred C57BL
  • Mice, Knockout
  • NIH 3T3 Cells
  • Peptide Initiation Factors
  • Protein Processing, Post-Translational
  • RNA-Binding Proteins
  • Signal Transduction
  • Spermidine

Keywords

  • B cell
  • TFEB
  • aging
  • autophagy
  • eIF5A
  • spermidine

TFPI

Identification of cardiovascular health gene variants related to longevity in a Chinese population.


Keywords

  • Chinese
  • factor related to cardiovascular health (FCH)
  • genetic variation
  • lipid metabolism
  • longevity

TG

Inhibition of the alternative lengthening of telomeres pathway by subtelomeric sequences in Saccharomyces cerevisiae.


Keywords

  • Budding yeast
  • Rad52
  • Replicative senescence
  • Subtelomeric Y’ elements
  • Telomerase-independent telomere maintenance
  • Telomere recombination


E4orf1, an Adeno-viral protein, attenuates renal lipid accumulation in high fat fed mice: A novel approach to reduce a key risk factor for chronic kidney disease.


Keywords

  • Aging
  • CKD
  • Diabetes
  • Diet
  • E4orf1
  • FA synthesis
  • Hyperinsulinemia
  • Insulin
  • Lipid metabolism
  • Obesity


Resistance exercise attenuates postprandial metabolic responses to a high-fat meal similarly in younger and older men.


Keywords

  • Aging
  • Cardiometabolic
  • Lipemia
  • Metabolism
  • Nutrition


Aging-induced aberrant RAGE/PPARα axis promotes hepatic steatosis via dysfunctional mitochondrial β oxidation.


Keywords

  • PPARα
  • RAGE
  • aging
  • hepatic steatosis
  • mitochondria


Fenofibrate impairs liver function and structure more pronounced in old than young rats.


Keywords

  • Aging
  • Fenofibrate
  • Lipids
  • Liver function and morphology
  • Rat
  • serum


Awareness of major cardiovascular risk factors and its relationship with markers of vascular aging: Data from the Brisighella Heart Study.


MeSH Terms

  • Adolescent
  • Adult
  • Age Factors
  • Aged
  • Aged, 80 and over
  • Aging
  • Biomarkers
  • Blood Glucose
  • Blood Pressure
  • Cardiovascular Diseases
  • Cholesterol
  • Cross-Sectional Studies
  • Diabetes Mellitus
  • Female
  • Humans
  • Hypercholesterolemia
  • Hypertension
  • Hypertriglyceridemia
  • Italy
  • Male
  • Middle Aged
  • Risk Assessment
  • Risk Factors
  • Triglycerides
  • Vascular Stiffness
  • Young Adult

Keywords

  • Arterial aging
  • Awareness
  • Epidemiology
  • Pulse wave velocity
  • Risk factors


Characterisation of the dynamic nature of lipids throughout the lifespan of genetically identical female and male Daphnia magna.


MeSH Terms

  • Aging
  • Animals
  • Daphnia
  • Diglycerides
  • Female
  • Lipid Metabolism
  • Longevity
  • Male
  • Phosphatidylcholines
  • Sphingomyelins
  • Triglycerides


Effects of laboratory biotic aging on the characteristics of biochar and its water-soluble organic products.


MeSH Terms

  • Benzopyrans
  • Charcoal
  • Humic Substances
  • Microbiota
  • Soil Microbiology
  • Solubility
  • Triticum
  • Water

Keywords

  • Biochar
  • Biotic incubation aging
  • Dissolved organic matter (DOM)
  • Excitation-emission matrix
  • Humification


Using Caenorhabditis elegans for Studying Trans- and Multi-Generational Effects of Toxicants.


MeSH Terms

  • Animals
  • Caenorhabditis elegans
  • Hazardous Substances
  • Humans
  • Longevity
  • Reproduction
  • Toxicity Tests

TH

Thyroid hormone signaling is associated with physical performance, muscle mass, and strength in a cohort of oldest-old: results from the Mugello study.


Keywords

  • Aging
  • Muscle mass
  • Muscle strength
  • Oldest-old
  • Physical performance
  • Rehabilitation
  • Thyroid hormone signaling


Social Environment Ameliorates Behavioral and Immune Impairments in Tyrosine Hydroxylase Haploinsufficient Female Mice.


Keywords

  • Behavioral responses
  • Immunosenescence
  • Oxidative-inflammatory stress
  • Social environmental strategy
  • Tyrosine hydroxylase haploinsufficient mice


Mechanism of thyroid hormone signaling in skeletal muscle of aging mice.


Keywords

  • Aging
  • Mice
  • Skeletal muscle
  • Thyroid hormone signaling


Longitudinal changes in bone mineral density and trabecular bone score in Korean adults: a community-based prospective study.


MeSH Terms

  • Absorptiometry, Photon
  • Adult
  • Bone Density
  • Cancellous Bone
  • Cohort Studies
  • Female
  • Humans
  • Lumbar Vertebrae
  • Male
  • Prospective Studies
  • Republic of Korea

Keywords

  • Aging
  • Bone mineral density
  • Natural history
  • Osteoporosis


Quantitative proteomic profiling of the rat substantia nigra places glial fibrillary acidic protein at the hub of proteins dysregulated during aging: Implications for idiopathic Parkinson's disease.


Keywords

  • RRID:AB_11145309
  • RRID:AB_2109791
  • RRID:AB_228307
  • RRID:AB_228341
  • RRID:AB_2336820
  • RRID:AB_2631098
  • RRID:AB_390204
  • RRID:MGI:5651135
  • RRID:SCR_001881
  • RRID:SCR_002798
  • RRID:SCR_003070
  • RRID:SCR_004946
  • RRID:SCR_005223
  • aging
  • dopaminergic neuron
  • glial fibrillary acidic protein
  • proteome
  • proteomics
  • substantia nigra


Withaferin-A Protects the Nigral Dopamine Neuron and Recovers Motor Activity in Aged Rats.


MeSH Terms

  • Aging
  • Animals
  • Brain
  • Corpus Striatum
  • Dopaminergic Neurons
  • Male
  • Motor Activity
  • Neuroprotective Agents
  • Rats
  • Rats, Wistar
  • Substantia Nigra
  • Tyrosine 3-Monooxygenase
  • Withanolides

Keywords

  • Ageing
  • Dopamine
  • Striatum
  • Substantia nigra
  • Withaferin-A


Effects of physical activity on bone mineral density in older adults: Korea National Health and Nutrition Examination Survey, 2008-2011.


MeSH Terms

  • Absorptiometry, Photon
  • Aged
  • Bone Density
  • Cross-Sectional Studies
  • Exercise
  • Female
  • Femur Neck
  • Humans
  • Lumbar Vertebrae
  • Male
  • Middle Aged
  • Nutrition Surveys
  • Osteoporosis
  • Republic of Korea
  • Surveys and Questionnaires

Keywords

  • Aging
  • Bone mineral density
  • Exercise
  • Gender
  • Osteoporosis
  • Physical activity


Age-Related Resistance to Thyroid Hormone Action.


MeSH Terms

  • Aged
  • Aged, 80 and over
  • Aging
  • Animals
  • Humans
  • Hyperthyroidism
  • Hypothyroidism
  • Iodide Peroxidase
  • Male
  • Receptors, Thyroid Hormone
  • Thyroid Hormones
  • Thyroxine
  • Triiodothyronine


Age-Dependent Changes in Glucose Homeostasis in Male Deiodinase Type 2 Knockout Zebrafish.


MeSH Terms

  • Aging
  • Animals
  • Animals, Genetically Modified
  • Glucose
  • Glucose Transport Proteins, Facilitative
  • Homeostasis
  • Hyperglycemia
  • Iodide Peroxidase
  • Islets of Langerhans
  • Male
  • Proglucagon
  • Proinsulin
  • Receptor, Insulin
  • Receptors, Glucagon
  • Zebrafish


Age effect on thyroid hormone brain response in male mice.


MeSH Terms

  • Aging
  • Animals
  • Brain
  • Gene Expression
  • Hyperthyroidism
  • Hypothyroidism
  • Male
  • Maze Learning
  • Mice, Inbred C57BL
  • Monocarboxylic Acid Transporters
  • Organic Cation Transport Proteins
  • Rotarod Performance Test
  • Symporters
  • Thyroid Hormones
  • Thyrotropin
  • Thyrotropin-Releasing Hormone

Keywords

  • Ageing
  • Hyperthyroidism
  • Hypothyroidism
  • Male mice
  • Thyroid hormones


Aging Is Associated with Low Thyroid State and Organ-Specific Sensitivity to Thyroxine.


MeSH Terms

  • Aging
  • Animals
  • DNA-Binding Proteins
  • Hypothalamo-Hypophyseal System
  • Liver
  • Male
  • Mice
  • Mice, Inbred C57BL
  • Myocardium
  • Pituitary Gland
  • Thyroid Gland
  • Thyroid Hormones
  • Thyrotropin
  • Thyroxine
  • Transcription Factors

Keywords

  • HPT-axis
  • aging
  • mice
  • thyroid gland
  • thyroid hormones

TLR1

Effects of aging and lifelong aerobic exercise on expression of innate immune components in human skeletal muscle.


Keywords

  • TLR
  • aging
  • innate immunity
  • lifelong exercise
  • skeletal muscle


Association of TLR gene variants in a Czech Red Pied cattle population with reproductive traits.


MeSH Terms

  • Age Factors
  • Animals
  • Breeding
  • Cattle
  • Czech Republic
  • Female
  • Genotype
  • Longevity
  • Male
  • Phenotype
  • Polymorphism, Single Nucleotide
  • Reproduction
  • Toll-Like Receptor 1
  • Toll-Like Receptor 2
  • Toll-Like Receptor 6
  • Toll-Like Receptors

Keywords

  • Cattle
  • Diversity
  • Effect prediction
  • Health traits
  • Toll-like receptors

TLR2

Changes in salivary microbial sensing proteins CD14 and TLR2 with aging.


MeSH Terms

  • Adolescent
  • Adult
  • Aging
  • Biomarkers
  • Child
  • Child, Preschool
  • Humans
  • Lipopolysaccharide Receptors
  • Middle Aged
  • Saliva
  • Salivary Proteins and Peptides
  • Toll-Like Receptor 2
  • Young Adult

Keywords

  • Age changes
  • CD14
  • Saliva
  • Toll-like receptor-2


Culture Model for Non-human Primate Choroid Plexus.


Keywords

  • aging
  • cell culture
  • choroid plexus
  • epithelial cell
  • infectious disease
  • rhesus macaque

TLR4

Age-Dependent Changes of Adipokine and Cytokine Secretion From Rat Adipose Tissue by Endogenous and Exogenous Toll-Like Receptor Agonists.


Keywords

  • adipokines
  • aging
  • batokines
  • biglycan
  • cytokines
  • fat explant cultures
  • high mobility group box-1 protein
  • lipopolysaccharide


Role of Toll Like Receptor 4 in Alzheimer's Disease.


Keywords

  • Alzheimer’s disease
  • TLR4
  • aging
  • amyloid beta oligomers
  • calcium
  • hippocampal neurons


Commentary on Some Recent Theses Relevant to Combating Aging: August 2020.


Keywords

  • aging
  • dissertations
  • theses


Sialylation and Galectin-3 in Microglia-Mediated Neuroinflammation and Neurodegeneration.


Keywords

  • aging
  • desialylation
  • galectin-3
  • microglia
  • neurodegeneration
  • phagocytosis
  • sialic acid


Chemerin facilitates intervertebral disc degeneration via TLR4 and CMKLR1 and activation of NF-kB signaling pathway.


Keywords

  • chemerin
  • inflammation
  • intervertebral disc
  • nucleus pulposus
  • senescence


Toll-like receptor 4 differentially regulates adult hippocampal neurogenesis in an age- and sex-dependent manner.


Keywords

  • TLR4
  • adult hippocampal neurogenesis
  • aging
  • proliferation
  • sex differences


Aging-associated immunosenescence via alterations in splenic immune cell populations in rat.


MeSH Terms

  • Animals
  • B-Lymphocytes
  • Cells, Cultured
  • Immunity, Cellular
  • Immunosenescence
  • Male
  • Malondialdehyde
  • Oxidative Stress
  • Rats
  • Rats, Wistar
  • Spleen
  • Superoxide Dismutase
  • T-Lymphocytes

Keywords

  • Aging
  • Immunohistochemistry
  • Immunosenescence
  • Oxidative stress
  • Spleen


Leptin induces immunosenescence in human B cells.


MeSH Terms

  • Adult
  • Aged
  • B-Lymphocytes
  • Humans
  • Immunoglobulin Class Switching
  • Immunosenescence
  • Leptin
  • Middle Aged
  • Obesity

Keywords

  • B cells
  • Immunosenescence
  • Leptin
  • Obesity


Genetic Variation in the Magnitude and Longevity of the IgG Subclass Response to a Diphtheria-Tetanus-Acellular Pertussis (DTaP) Vaccine in Mice.


Keywords

  • DTaP
  • IgG subclass
  • antibody longevity
  • antibody magnitude
  • genetics
  • vaccine


Rapamycin improves sevoflurane‑induced cognitive dysfunction in aged rats by mediating autophagy through the TLR4/MyD88/NF‑κB signaling pathway.


MeSH Terms

  • Aging
  • Animals
  • Autophagic Cell Death
  • Cognitive Dysfunction
  • Male
  • Myeloid Differentiation Factor 88
  • NF-kappa B
  • Rats
  • Rats, Sprague-Dawley
  • Sevoflurane
  • Signal Transduction
  • Sirolimus
  • Toll-Like Receptor 4

TLR9

Age-Associated B Cells.


Keywords

  • B lymphocytes
  • aging
  • autoimmunity
  • memory B cells

TMEM106B

Genetics of Gene Expression in the Aging Human Brain Reveal TDP-43 Proteinopathy Pathophysiology.


MeSH Terms

  • Aged
  • Aged, 80 and over
  • Aging
  • Alzheimer Disease
  • Amyloid beta-Peptides
  • Apolipoproteins E
  • Brain
  • Cohort Studies
  • DNA-Binding Proteins
  • Female
  • Gene Expression Regulation
  • Haplotypes
  • Humans
  • Lysosomes
  • Male
  • Membrane Proteins
  • Myelin Sheath
  • Nerve Tissue Proteins
  • Progranulins
  • Quantitative Trait Loci
  • RNA Splicing Factors
  • TDP-43 Proteinopathies

Keywords

  • Alzheimer's disease
  • Amyloid-β
  • GRN
  • RBFOX1
  • TDP-43
  • TMEM106B
  • co-expression module
  • cognitive resilience
  • eQTL
  • expression quantitative trait loci
  • sQTL
  • splicing quantitative trait loci

TMPRSS2

Susceptibility to COVID-19 in populations with health disparities: Posited involvement of mitochondrial disorder, socioeconomic stress, and pollutants.


Keywords

  • SARS-CoV-2
  • dysfunction
  • exposome
  • immunosenescence
  • metabolomics
  • mitochondria
  • pollutant
  • socioeconomic
  • stress


Expression of the SARS-CoV-2 Entry Proteins, ACE2 and TMPRSS2, in Cells of the Olfactory Epithelium: Identification of Cell Types and Trends with Age.


MeSH Terms

  • Age Factors
  • Angiotensin-Converting Enzyme 2
  • Animals
  • Betacoronavirus
  • COVID-19
  • Coronavirus Infections
  • Gene Expression
  • Gene Expression Profiling
  • Immunohistochemistry
  • In Situ Hybridization
  • Mice
  • Olfaction Disorders
  • Olfactory Mucosa
  • Olfactory Receptor Neurons
  • Pandemics
  • Peptidyl-Dipeptidase A
  • Pneumonia, Viral
  • RNA-Seq
  • Reverse Transcriptase Polymerase Chain Reaction
  • SARS-CoV-2
  • Serine Endopeptidases
  • Virus Internalization

Keywords

  • ACE2 expression
  • COVID-19
  • SARS-CoV-2
  • aging
  • anosmia
  • olfactory epithelium

TNC

Effects of Tenascin C on the Integrity of Extracellular Matrix and Skin Aging.


Keywords

  • TGF-β
  • aging
  • collagen
  • extracellular matrix
  • fibroblast
  • skin
  • tenascin C


Tenascin-C expression controls the maturation of articular cartilage in mice.


MeSH Terms

  • Aging
  • Animals
  • Cartilage, Articular
  • Cell Count
  • Genotype
  • Mice
  • Tenascin

Keywords

  • Adhesion
  • Articular cartilage
  • Cartilage defect
  • Cell density
  • Knock-out mouse
  • Load
  • Tenascin C


Effects of hydrothermal aging, thermal cycling, and water storage on the mechanical properties of a machinable resin-based composite containing nano-zirconia fillers.


Keywords

  • Aging
  • Mechanical properties
  • Nano-zirconia
  • Phase transformation
  • Resin nano-ceramic
  • Resin-based composite

TNF

Naringenin alleviates nonalcoholic steatohepatitis in middle-aged Apoe mice: role of SIRT1.


Keywords

  • AML-12 cells
  • Aging
  • ApoE(−/−) mice
  • Naringenin
  • Nonalcoholic steatohepatitis
  • SIRT1


Protective role of microglial HO-1 blockade in aging: Implication of iron metabolism.


Keywords

  • Aging
  • Ferroptosis
  • Heme oxygenase-1
  • Iron metabolism
  • Microglia
  • Neuroinflammation


Anti-aging effect of DL-β-hydroxybutyrate against hepatic cellular senescence induced by D-galactose or γ-irradiation via autophagic flux stimulation in male rats.


Keywords

  • Autophagy
  • D-galacose
  • Ionizing radiation
  • Senescence
  • β-hydroxybutyric acid


Exploring the extensive crosstalk between the antagonistic cytokines- TGF-β and TNF-α in regulating cancer pathogenesis.


Keywords

  • Apoptosis
  • Autophagy
  • EMT
  • Fibrogenesis
  • Senescence
  • TGF-β and TNF-α


Long non-coding RNA SNHG29 regulates cell senescence via p53/p21 signaling in spontaneous preterm birth.


Keywords

  • Cellular senescence
  • Oxidative stress
  • SASP
  • SNHG29
  • Spontaneous preterm birth
  • p53/p21


Cognition Is Associated With Peripheral Immune Molecules in Healthy Older Adults: A Cross-Sectional Study.


Keywords

  • chemokines
  • cognition
  • cytokines
  • healthy aging
  • immune molecules


Anti-aging effects of [i]Ribes meyeri[/i] anthocyanins on neural stem cells and aging mice.


Keywords

  • Ribes meyeri anthocyanin
  • aging
  • cognition
  • naringenin
  • senescence


Effects of a four week detraining period on physical, metabolic, and inflammatory profiles of elderly women who regularly participate in a program of strength training.


Keywords

  • Aging
  • Inflammation
  • Physical exercise


Contribution of Porphyromonas gingivalis lipopolysaccharide to experimental periodontitis in relation to aging.


Keywords

  • Aging
  • Bone loss
  • Osteoclastogenesis
  • Periodontitis
  • Porphyromonas gingivalis lipopolysaccharide


New MoDC-Targeting TNF Fusion Proteins Enhance Cyclic Di-GMP Vaccine Adjuvanticity in Middle-Aged and Aged Mice.


Keywords

  • 3′
  • 5′-cyclic diguanylic acid (cyclic di-GMP)
  • aging
  • monocyte-derived dendritic cells (moDCs)
  • tumor necrosis factor (TNF)
  • vaccine


Cognitive impairment in elderly patients with rheumatic disease and the effect of disease-modifying anti-rheumatic drugs.


Keywords

  • Aging
  • Biologics
  • Cognition
  • Rheumatic diseases


Cotinine ameliorates memory and learning impairment in senescent mice.


Keywords

  • Aging
  • Cognitive impairment
  • Cotinine
  • Improvement
  • α(7)nAChRs


Kynurenines link chronic inflammation to functional decline and physical frailty.


Keywords

  • Aging
  • Cytokines
  • Inflammation
  • Neurodegeneration


Voluntary exercise training attenuated the middle-aged maturity-induced cardiac apoptosis.


MeSH Terms

  • Aging
  • Animals
  • Apoptosis
  • Heart
  • In Situ Nick-End Labeling
  • Male
  • Mice
  • Mice, Inbred C57BL
  • Mitochondria, Heart
  • Muscle, Skeletal
  • Physical Conditioning, Animal
  • Running
  • Sedentary Behavior

Keywords

  • Caspase-independent
  • Cell death
  • Fas dependent
  • IGF-related
  • Mitochondrial


Preclinical Evaluation of a Food-Derived Functional Ingredient to Address Skeletal Muscle Atrophy.


Keywords

  • aging
  • bioactive
  • functional ingredient
  • immobilization
  • inflammation
  • muscle atrophy
  • peptide
  • protein synthesis
  • skeletal muscle


Childhood survivors of high-risk neuroblastoma show signs of immune recovery and not immunosenescence.


Keywords

  • adverse late effects
  • childhood
  • immune recovery
  • immunosenescence
  • neuroblastoma


FK506 induces lung lymphatic endothelial cell senescence and downregulates LYVE-1 expression, with associated decreased hyaluronan uptake.


Keywords

  • Endothelial cells
  • Fk506
  • Hyaluronan
  • LYVE-1
  • Lung lymphatic
  • Senescence
  • TERT


Late-onset hypogonadism: Reductio ad absurdum of the cardiovascular risk-benefit of testosterone replacement therapy.


Keywords

  • aging
  • androgen
  • heart failure
  • myocardial infarction
  • testosterone
  • thromboembolism


Doxorubicin generates senescent microglia that exhibit altered proteomes, higher levels of cytokine secretion, and a decreased ability to internalize amyloid β.


Keywords

  • Aging
  • Alzheimer's disease
  • Inflammation
  • Microglia
  • Proteomics
  • Senescence


Time restricted feeding provides a viable alternative to alternate day fasting when evaluated in terms of redox homeostasis in rats.


Keywords

  • Aging
  • Alternate day fasting (ADF)
  • Intermittent fasting (IF)
  • Oxidative stress
  • Time-Restricted feeding (TRF)


Associations Between Plasma Immunomodulatory and Inflammatory Mediators With VACS Index Scores Among Older HIV-Infected Adults on Antiretroviral Therapy.


Keywords

  • HIV
  • aging
  • anti-retroviral therapy
  • inflammation
  • morbidity


Chrysin Impact on Oxidative and Inflammation Damages in the Liver of Aged Male Rats.


Keywords

  • Aging
  • chrysin
  • inflammation
  • liver
  • oxidative stress
  • rat.


Correction of immunosuppression in aged septic rats by human ghrelin and growth hormone through the vagus nerve-dependent inhibition of TGF-β production.


Keywords

  • Aging
  • Ghrelin
  • Immunosuppression
  • Sepsis
  • Vagus nerve


Epigenetics of neuroinflammation: Immune response, inflammatory response and cholinergic synaptic involvement evidenced by genome-wide DNA methylation analysis of delirious inpatients.


Keywords

  • Aging
  • Delirium
  • Genome-wide DNA methylation
  • Immune response
  • Inflammatory response


[i]Andrographis paniculata[/i] and Its Bioactive Diterpenoids Against Inflammation and Oxidative Stress in Keratinocytes.


Keywords

  • Andrographis paniculata
  • andrographolide
  • inflammation
  • keratinocytes
  • oxidative stress
  • skin aging


Etanercept improves aging-induced cognitive deficits by reducing inflammation and vascular dysfunction in rats.


Keywords

  • Aging
  • Etanercept
  • Inflammation
  • Learning
  • Memory
  • TNFα
  • Vascular dementia


Bacterial antigen translocation and age as BMI-independent contributing factors on systemic inflammation in NAFLD patients.


Keywords

  • NAFLD
  • aging
  • bacterial translocation
  • cytokines
  • insulin resistance


Bone marrow mesenchymal stem cells improve thymus and spleen function of aging rats through affecting P21/PCNA and suppressing oxidative stress.


Keywords

  • BMSCs
  • P21/PCNA
  • aging
  • immune system
  • oxidative stress


Glycolic acid adjusted to pH 4 stimulates collagen production and epidermal renewal without affecting levels of proinflammatory TNF-alpha in human skin explants.


Keywords

  • cosmetics
  • glycolic acid
  • keratolytic agents
  • rejuvenation
  • skin aging


A20 of nucleus pulposus cells plays a self-protection role via the nuclear factor-kappa B pathway in the inflammatory microenvironment.


Keywords

  • A20
  • Nuclear factor-kappa B
  • Nucleus pulposus
  • Senescence
  • Tumour necrosis factor alpha


Age-associated decline in neural, endocrine, and immune responses in men and women: Involvement of intracellular signaling pathways.


MeSH Terms

  • Adult
  • Aging
  • Estradiol
  • Female
  • Humans
  • Hydrocortisone
  • Immunity, Cellular
  • Intracellular Fluid
  • Male
  • Middle Aged
  • Signal Transduction
  • Testosterone
  • Young Adult

Keywords

  • 17β-estradiol
  • Cortisol
  • Cytokines
  • Testosterone
  • Tyrosine hydroxylase


Classical and lectin complement pathways and markers of inflammation for investigation of susceptibility to infections among healthy older adults.


Keywords

  • Aging
  • Complement system
  • Elderly
  • Immune
  • Inflammation
  • Lectin


Activation of FoxO1/SIRT1/RANKL/OPG pathway may underlie the therapeutic effects of resveratrol on aging-dependent male osteoporosis.


Keywords

  • Aging
  • FoxO1
  • Male osteoporosois
  • OPG
  • RANKL
  • Resveratrol
  • SIRT1
  • Type II osteoporosis


The senescence-associated secretome as an indicator of age and medical risk.


Keywords

  • Aging
  • Cellular senescence


Exercise Partially Rejuvenates Muscle Stem Cells.


Keywords

  • TGF-beta
  • aging
  • cyclin D1
  • longevity
  • regeneration
  • stem cells


Brazilian berry extract (Myrciaria jaboticaba): A promising therapy to minimize prostatic inflammation and oxidative stress.


MeSH Terms

  • Age Factors
  • Animals
  • Anti-Inflammatory Agents
  • Antioxidants
  • Cyclooxygenase 2
  • Diet, High-Fat
  • Dose-Response Relationship, Drug
  • Fruit
  • Interleukin-1beta
  • Interleukin-6
  • Lipid Peroxidation
  • Male
  • Mice
  • Myrtaceae
  • Oxidative Stress
  • Plant Extracts
  • Prostatitis
  • T-Lymphocytes

Keywords

  • aging
  • bioactive compounds
  • obesity
  • overweight
  • polyphenols


Potential therapeutic effects of endothelial cells trans-differentiated from Wharton's Jelly-derived mesenchymal stem cells on altered vascular functions in aged diabetic rat model.


Keywords

  • Aging
  • Diabetes mellitus
  • Endothelial cells
  • Hypertension
  • Mesenchymal stem cells


[Effect of fragmented sleep on postoperative cognitive function and central neuroinflammation].


MeSH Terms

  • Aging
  • Animals
  • Cognition
  • Cognition Disorders
  • Fear
  • Hippocampus
  • Mice
  • Mice, Inbred ICR

Keywords

  • Central nervous system
  • Cognition disorders
  • Inflammation
  • Postoperative period
  • Sleep deprivation


Can blocking inflammation enhance immunity during aging?


Keywords

  • Inflammaging
  • p38-MAP Kinase
  • senescence
  • senolytics


[FAS- and TNF-dependent ways participation in apoptosis mechanisms in hypotalumus in physiological and pathological aging.]


MeSH Terms

  • Aging
  • Animals
  • Apoptosis
  • Female
  • Hypothalamus
  • Mice
  • Mice, Transgenic
  • Signal Transduction
  • Tumor Necrosis Factor-alpha
  • fas Receptor

Keywords

  • FAS-, TNF-dependent pathways
  • aging
  • apoptosis
  • hypothalamus
  • neurons


Ultrasound-guided continuous thoracic paravertebral block alleviates postoperative delirium in elderly patients undergoing esophagectomy: A randomized controlled trial.


MeSH Terms

  • Aged
  • Aged, 80 and over
  • Analgesia, Patient-Controlled
  • Delirium
  • Esophagectomy
  • Female
  • Geriatrics
  • Humans
  • Male
  • Middle Aged
  • Nerve Block
  • Postoperative Complications
  • Prospective Studies
  • Ultrasonography


17β-Estradiol improves insulin signalling and insulin resistance in the aged female hearts: Role of inflammatory and anti-inflammatory cytokines.


MeSH Terms

  • Aging
  • Animals
  • Anti-Inflammatory Agents
  • Blood Glucose
  • Cytokines
  • Estradiol
  • Female
  • Heart
  • Insulin
  • Insulin Resistance
  • Lipid Metabolism
  • Menopause
  • Ovariectomy
  • Rats
  • Rats, Wistar
  • Signal Transduction

Keywords

  • 17β-estradiol
  • Aging
  • Cytokines
  • Heart
  • Insulin signalling


Synergistic Antitumor Efficacy of Magnetohyperthermia and Poly(lactic-co-glycolic acid)-Encapsulated Selol in Ehrlich Breast Adenocarcinoma Treatment in Elderly Swiss Mice.


MeSH Terms

  • Adenocarcinoma
  • Aging
  • Animals
  • Cell Line, Tumor
  • Glycols
  • Humans
  • Mice
  • Nanoparticles
  • Polylactic Acid-Polyglycolic Acid Copolymer
  • Selenium Compounds


Pinitol suppresses TNF-α-induced chondrocyte senescence.


Keywords

  • Cellular senescence
  • Nrf2
  • Osteoarthritis
  • Pinitol
  • TNF-α


[Aging of skin fibroblasts: genetic and epigenetic factors.]


MeSH Terms

  • Cells, Cultured
  • Epigenesis, Genetic
  • Fibroblasts
  • Humans
  • Skin Aging

Keywords

  • aging
  • melatonin
  • signal molecules
  • skin fibroblasts


Functional and traditional training improve muscle power and reduce proinflammatory cytokines in older women: A randomized controlled trial.


Keywords

  • Aging
  • Cytokines.
  • Dynapenia
  • Inflamm-aging


Associations of TNF-α -308 G>A and TNF-β 252 A>G with Physical Function and BNP-Rugao Longevity and Ageing Study.


MeSH Terms

  • Aged
  • Aged, 80 and over
  • Aging
  • Female
  • Humans
  • Longevity
  • Male
  • Natriuretic Peptide, Brain
  • Tumor Necrosis Factor-alpha

Keywords

  • Physical function
  • TNF-α -308 G>A polymorphism
  • TNF-β 252 A>G polymorphism
  • plasma BNP
  • population study.


3D TECA hydrogel reduces cellular senescence and enhances fibroblasts migration in wound healing.


Keywords

  • 3D TECA
  • Cellular senescence
  • Fibroblast migration
  • SA-β-gal
  • TNF-α


Regulatory Effect of Anwulignan on the Immune Function Through Its Antioxidation and Anti-Apoptosis in D-Galactose-Induced Aging Mice.


MeSH Terms

  • Animals
  • Antioxidants
  • Apoptosis
  • Cytokines
  • Immunologic Factors
  • Immunosenescence
  • Male
  • Medicine, Chinese Traditional
  • Mice
  • Models, Animal
  • NF-E2-Related Factor 2
  • Oxidative Stress
  • Phytochemicals
  • Schisandra
  • Spleen

Keywords

  • Anwulignan
  • anti-apoptosis
  • antioxidation
  • immunosenescence


Pretreatment Frailty Is Independently Associated With Increased Risk of Infections After Immunosuppression in Patients With Inflammatory Bowel Diseases.


Keywords

  • Aging
  • Immunosuppression
  • Side Effect
  • Thiopurine


The Citrus Flavonoid Naringenin Protects the Myocardium from Ageing-Dependent Dysfunction: Potential Role of SIRT1.


MeSH Terms

  • Aging
  • Animals
  • Antioxidants
  • Cell Line
  • Cellular Senescence
  • Citrus
  • Cytoprotection
  • Disease Models, Animal
  • Flavanones
  • Humans
  • Interleukin-6
  • Mice
  • Myocardium
  • Protein Binding
  • Rats
  • Reactive Oxygen Species
  • Sirtuin 1
  • Tumor Necrosis Factor-alpha


In the Absence of a TCR Signal IL-2/IL-12/18-Stimulated γδ T Cells Demonstrate Potent Anti-Tumoral Function Through Direct Killing and Senescence Induction in Cancer Cells.


Keywords

  • IL-12
  • IL-18
  • TCR bypass stimulation
  • senescence
  • γδ T cells


Aging is associated with loss of beneficial effects of estrogen on leptin responsiveness in mice fed high fat diet: Role of estrogen receptor α and cytokines.


Keywords

  • Aging
  • Cytokines
  • ERα
  • Estrogen
  • Leptin sensitivity


Mitochondrial Dysfunction and Alpha-Lipoic Acid: Beneficial or Harmful in Alzheimer's Disease?


MeSH Terms

  • Aging
  • Alzheimer Disease
  • Amyloid beta-Peptides
  • Animals
  • Cytokines
  • Humans
  • Inflammation Mediators
  • Mitochondria
  • Neurofibrillary Tangles
  • Neurons
  • Neuroprotective Agents
  • Thioctic Acid


Design, synthesis and evaluation of diosgenin carbamate derivatives as multitarget anti-Alzheimer's disease agents.


MeSH Terms

  • Aging
  • Alzheimer Disease
  • Amyloid beta-Peptides
  • Animals
  • Anti-Inflammatory Agents, Non-Steroidal
  • Astrocytes
  • Carbamates
  • Cell Line, Tumor
  • Cell Survival
  • Diosgenin
  • Dose-Response Relationship, Drug
  • Drug Design
  • Galactose
  • Humans
  • Inflammation
  • Male
  • Mice
  • Mice, Inbred ICR
  • Molecular Structure
  • Neuroprotective Agents
  • Oxidative Stress
  • Protein Aggregates
  • Structure-Activity Relationship

Keywords

  • Alzheimer’s disease
  • Anti-Aβ activity
  • Anti-inflammatory
  • Antioxidant
  • Diosgenin
  • Multi-target-directed ligands


Oral Administration of Okara Soybean By-Product Attenuates Cognitive Impairment in a Mouse Model of Accelerated Aging.


MeSH Terms

  • Aging
  • Animal Feed
  • Animals
  • Brain-Derived Neurotrophic Factor
  • Cognitive Dysfunction
  • Diet
  • Gastrointestinal Microbiome
  • Gene Expression Regulation
  • Hippocampus
  • Male
  • Mice
  • Soybeans
  • Tumor Necrosis Factor-alpha

Keywords

  • BDNF
  • SAMP8
  • cognitive impairment
  • neuroprotection
  • okara


Electric vagal nerve stimulation inhibits inflammation and improves early postoperation cognitive dysfunction in aged rats.


MeSH Terms

  • Aging
  • Anesthesia, General
  • Animals
  • Behavior, Animal
  • Hippocampus
  • Inflammation
  • Male
  • Maze Learning
  • NF-kappa B
  • Postoperative Cognitive Complications
  • Rats
  • Rats, Sprague-Dawley
  • Splenectomy
  • Tumor Necrosis Factor-alpha
  • Vagus Nerve Stimulation

Keywords

  • Cognitive dysfunction
  • General anesthesia
  • Inflammation
  • Vagus nerve stimulation


Metformin decreases LPS-induced inflammatory response in rabbit annulus fibrosus stem/progenitor cells by blocking HMGB1 release.


MeSH Terms

  • Animals
  • Annulus Fibrosus
  • Anti-Inflammatory Agents
  • Cellular Senescence
  • HMGB1 Protein
  • Inflammation
  • Intervertebral Disc Degeneration
  • Lipopolysaccharides
  • Metformin
  • Rabbits
  • Stem Cells

Keywords

  • HMGB1
  • annulus fibrosis stem cells
  • cell senescence
  • intervertebral disc degeneration
  • metformin


The effects of blueberry and strawberry serum metabolites on age-related oxidative and inflammatory signaling in vitro.


MeSH Terms

  • Aged
  • Aging
  • Animals
  • Blueberry Plants
  • Double-Blind Method
  • Female
  • Fragaria
  • Fruit
  • Humans
  • Male
  • Microglia
  • Middle Aged
  • Nitric Oxide
  • Nitric Oxide Synthase Type II
  • Oxidative Stress
  • Postprandial Period
  • Rats
  • Tumor Necrosis Factor-alpha


Arsenic induces human chondrocyte senescence and accelerates rat articular cartilage aging.


Keywords

  • Aging
  • Arsenic
  • Articular cartilage
  • Human chondrocyte
  • Senescence
  • Senescence-associated secretory phenotype


Bone Benefits of Fish Oil Supplementation Depend on its EPA and DHA Content.


MeSH Terms

  • Age Factors
  • Animals
  • Bone Density
  • Bone Density Conservation Agents
  • Bone Marrow Cells
  • Bone Remodeling
  • Bone and Bones
  • Cells, Cultured
  • Cytokines
  • Dietary Supplements
  • Disease Models, Animal
  • Docosahexaenoic Acids
  • Eicosapentaenoic Acid
  • Female
  • JNK Mitogen-Activated Protein Kinases
  • Mice, Inbred C57BL
  • Osteoporosis
  • Signal Transduction
  • p38 Mitogen-Activated Protein Kinases

Keywords

  • aging
  • bone mineral density
  • bone resorption
  • concentrated fish oil
  • cytokines
  • inflammation
  • omega-3 fatty acids


Inflammaging phenotype in rhesus macaques is associated with a decline in epithelial barrier-protective functions and increased pro-inflammatory function in CD161-expressing cells.


MeSH Terms

  • Aging
  • Animals
  • Chronic Disease
  • Cytokines
  • Disease Models, Animal
  • Epithelium
  • Flow Cytometry
  • Immunity, Innate
  • Inflammation
  • Macaca mulatta
  • NK Cell Lectin-Like Receptor Subfamily B
  • Phenotype
  • Th17 Cells

Keywords

  • CD161+ cells
  • I-FABP
  • Inflammaging
  • LBP
  • Leaky gut
  • sCD14


Single-cell transcriptomics reveals expansion of cytotoxic CD4 T cells in supercentenarians.


MeSH Terms

  • Adult
  • Aged
  • Aged, 80 and over
  • B-Lymphocytes
  • CD4-Positive T-Lymphocytes
  • Case-Control Studies
  • Cell Differentiation
  • Cells, Cultured
  • Clonal Evolution
  • Gene Expression Profiling
  • Humans
  • Interferon-gamma
  • Leukocytes, Mononuclear
  • Middle Aged
  • Single-Cell Analysis
  • Tumor Necrosis Factor-alpha

Keywords

  • CD4 CTL
  • aging
  • centenarian
  • single-cell transcriptome


Gut microbiota combined with metabolomics reveals the metabolic profile of the normal aging process and the anti-aging effect of FuFang Zhenshu TiaoZhi(FTZ) in mice.


MeSH Terms

  • Aging
  • Animals
  • Bacteria
  • Biomarkers
  • Drugs, Chinese Herbal
  • Gastrointestinal Microbiome
  • Hyperlipidemias
  • Lipid Metabolism
  • Male
  • Metabolome
  • Metabolomics
  • Mice
  • Mice, Inbred C57BL

Keywords

  • Aging
  • FTZ
  • Gut microbiota
  • Metabolomics


Intervertebral disc ageing and degeneration: The antiapoptotic effect of oestrogen.


MeSH Terms

  • Aging
  • Animals
  • Apoptosis
  • Cytokines
  • Estrogens
  • Female
  • Humans
  • Inflammation
  • Intervertebral Disc
  • Intervertebral Disc Degeneration
  • Intervertebral Disc Displacement
  • Male
  • Phosphatidylinositol 3-Kinases
  • Signal Transduction

Keywords

  • Ageing
  • Apoptosis
  • Intervertebral disc degeneration
  • Oestrogen
  • Spine


MicroRNA 16-5p is upregulated in calorie-restricted mice and modulates inflammatory cytokines of macrophages.


MeSH Terms

  • Aging
  • Animals
  • Caloric Restriction
  • Cytokines
  • Diet Therapy
  • Inflammation
  • Interleukin-1beta
  • Macrophages
  • Male
  • Mice
  • Mice, Inbred C57BL
  • MicroRNAs
  • Models, Animal
  • RAW 264.7 Cells
  • Transcriptional Activation
  • Tumor Necrosis Factor-alpha
  • Up-Regulation

Keywords

  • Caloric restriction
  • Cellular immunology
  • Cytokines
  • Macrophages
  • microRNA


Aerobic exercise modulates cytokine profile and sleep quality in elderly.


MeSH Terms

  • Aged
  • Cytokines
  • Exercise
  • Female
  • Humans
  • Male
  • Middle Aged
  • Sedentary Behavior
  • Sleep Wake Disorders

Keywords

  • Sleep quality
  • aerobic exercise
  • aging
  • inflammatory cytokines


Trehalose targets Nrf2 signal to alleviate d-galactose induced aging and improve behavioral ability.


MeSH Terms

  • Aging
  • Animals
  • Disease Models, Animal
  • Dose-Response Relationship, Drug
  • Galactose
  • Male
  • Memory Disorders
  • Mice
  • Mice, Inbred ICR
  • NF-E2-Related Factor 2
  • Signal Transduction
  • Trehalose

Keywords

  • Antioxidant stress
  • Cognitive impairment
  • Inflammation
  • Nrf2
  • Trehalose
  • d-galactose


Anti-Inflammatory and Anti-Aging Evaluation of Pigment-Protein Complex Extracted from [i]Chlorella Pyrenoidosa[/i].


MeSH Terms

  • Aging
  • Animals
  • Anti-Inflammatory Agents
  • Antioxidants
  • Biological Products
  • Chlorella
  • Cytokines
  • Disease Models, Animal
  • Galactose
  • Inflammation
  • Interleukin-6
  • Lipopolysaccharides
  • Macrophages
  • Male
  • Mice
  • Mice, Inbred C57BL
  • NF-kappa B
  • Nitric Oxide
  • Oxidative Stress
  • RAW 264.7 Cells
  • Superoxide Dismutase
  • Tumor Necrosis Factor-alpha

Keywords

  • Chlorella pyrenoidosa
  • NF-κB
  • PPARs
  • anti-aging
  • anti-inflammation
  • pigment–protein complex


Inflammatory mediators and the risk of falls among older women with acute low back pain: data from Back Complaints in the Elders (BACE)-Brazil.


Keywords

  • Aging
  • BACE
  • Cytokines
  • Disability
  • Fall risk
  • Low back pain


Acetylcholinesterase inhibitors targeting the cholinergic anti-inflammatory pathway: a new therapeutic perspective in aging-related disorders.


Keywords

  • Acetylcholinesterase inhibitor
  • Aging
  • CHRFAM7A
  • CHRNA7
  • Cholinergic anti-inflammatory pathway
  • Neuroinflammation


Study on Metabolic Trajectory of Liver Aging and the Effect of Fufang Zhenzhu Tiaozhi on Aging Mice.


Keywords

  • Fufang Zhenzhu Tiaozhi
  • liver aging
  • mass spectrometry
  • metabolomics
  • ultra-performance liquid chromatography


Systemic Tumor Necrosis Factor-Alpha Trajectories Relate to Brain Health in Typically Aging Older Adults.


Keywords

  • Brain aging
  • Cognition
  • Gray matter volume
  • Inflammation
  • Neuroimaging


Targeting senescence improves angiogenic potential of adipose-derived mesenchymal stem cells in patients with preeclampsia.


MeSH Terms

  • Adipose Tissue
  • Adult
  • Cell Movement
  • Cell Proliferation
  • Cell Survival
  • Cellular Senescence
  • Dasatinib
  • Female
  • Humans
  • Mesenchymal Stem Cells
  • Pre-Eclampsia
  • Pregnancy
  • Protein Kinase Inhibitors

Keywords

  • Angiogenesis, Senolytics, Dasatinib
  • Mesenchymal stem cells
  • Preeclampsia
  • Senescence


Suppression of gut dysbiosis by Bifidobacterium longum alleviates cognitive decline in 5XFAD transgenic and aged mice.


MeSH Terms

  • Aging
  • Animals
  • Bifidobacterium longum
  • Cognitive Dysfunction
  • Dysbiosis
  • Feces
  • Gastrointestinal Microbiome
  • Humans
  • Lipopolysaccharides
  • Mice
  • Mice, Transgenic
  • Probiotics


Moderate hyperoxia induces senescence in developing human lung fibroblasts.


MeSH Terms

  • Autophagy
  • CCAAT-Enhancer-Binding Protein-beta
  • Cell Proliferation
  • Cellular Senescence
  • Cyclin-Dependent Kinase Inhibitor p21
  • DNA Damage
  • Endoplasmic Reticulum Stress
  • Etoposide
  • Extracellular Matrix
  • Fetus
  • Fibroblasts
  • G2 Phase Cell Cycle Checkpoints
  • Gene Expression Regulation
  • Humans
  • Hyperoxia
  • Interleukin-1
  • Interleukin-8
  • Lung
  • Matrix Metalloproteinase 3
  • Oxygen
  • Plasminogen Activator Inhibitor 1
  • Primary Cell Culture
  • Tumor Necrosis Factor-alpha
  • Tumor Suppressor Protein p53

Keywords

  • autophagy
  • endoplasmic reticulum stress
  • lung development
  • oxygen
  • senescence


Aging-related carcinoembryonic antigen-related cell adhesion molecule 1 signaling promotes vascular dysfunction.


MeSH Terms

  • Aged
  • Aging
  • Animals
  • Antigens, CD
  • Cell Adhesion Molecules
  • Cells, Cultured
  • Endothelium, Vascular
  • Humans
  • Mice
  • Mice, Inbred C57BL
  • Mice, Knockout
  • Middle Aged
  • Signal Transduction

Keywords

  • aging
  • anti-aging
  • cytokines
  • inflammation
  • mouse
  • reactive oxygen species


Microglia Express Insulin-Like Growth Factor-1 in the Hippocampus of Aged APP /PS1 Transgenic Mice.


Keywords

  • aging
  • cerebral amyloidosis
  • insulin-like growth factor
  • neurogenesis
  • neuroinflammation
  • tumor necrosis factor


Age- and diet-specific effects of chronic exposure to chlorpyrifos on hormones, inflammation and gut microbiota in rats.


MeSH Terms

  • Aging
  • Animals
  • Chlorpyrifos
  • Diet, High-Fat
  • Gastrointestinal Microbiome
  • Hypothalamo-Hypophyseal System
  • Inflammation
  • Male
  • Pituitary-Adrenal System
  • RNA, Ribosomal, 16S
  • Rats

Keywords

  • 16S rRNA gene sequencing
  • Gut endocrine
  • Gut-brain axis
  • Hormone
  • Hypothalamic-pituitary-adrenal axis
  • Inflammation

TOMM20

Effect of aging on mitochondria and metabolism of bovine granulosa cells.


Keywords

  • Aging
  • Cow
  • Granulosa cells
  • Mitochondria

TP53

p53 inhibits the osteogenic differentiation but does not induce senescence in human dental follicle cells.


Keywords

  • Cellular senescence
  • Dental follicle cells
  • E2F-1
  • Osteogenic differentiation
  • p53


Mutational spectrum and dynamics of clonal hematopoiesis in anemia of older individuals.


MeSH Terms

  • Age Factors
  • Aged
  • Aging
  • Anemia
  • Female
  • Hematopoiesis
  • Humans
  • Kaplan-Meier Estimate
  • Male
  • Middle Aged
  • Mutation
  • Prospective Studies


TP53/miR-34a-associated signaling targets [i]SERPINE1[/i] expression in human pancreatic cancer.


Keywords

  • Aging
  • PDAC
  • SERPINE1
  • TP53
  • cancer
  • miR-34a


Expression of p16 in nodular fasciitis: an implication for self-limited and inflammatory nature of the lesion.


Keywords

  • CDK4
  • MDM2
  • TP53
  • nodular fasciitis
  • p16
  • senescence

TPH1

[i]Lactobacillus plantarum[/i] DR7 improved brain health in aging rats via the serotonin, inflammatory and apoptosis pathways.


Keywords

  • Lactobacillus spp.
  • aging
  • brain

TPO

Megakaryocytes promote osteoclastogenesis in aging.


Keywords

  • aging
  • bone marrow macrophage
  • megakaryocyte
  • osteoclast
  • thrombopoietin

TPP1

FBW7 Mediates Senescence and Pulmonary Fibrosis through Telomere Uncapping.


Keywords

  • DNA damage response
  • FBXW7
  • TPP1
  • cellular senescence
  • chronic stress
  • idiopathic pulmonary fibrosis
  • premature aging
  • proteostasis
  • stem cells
  • telomere
  • telomere uncapping

TPR

Catalytic Performances of Cu/MCM-22 Zeolites with Different Cu Loadings in NH -SCR.


Keywords

  • Cu loading
  • Cu/MCM-22
  • NH3-SCR
  • hydrothermal aging


Do traits of plant species predict the efficacy of species distribution models for finding new occurrences?


Keywords

  • dispersal
  • generalist
  • lifespan
  • niche models
  • range size
  • specialist


In-situ modified the surface of Pt-doped perovskite catalyst for soot oxidation.


Keywords

  • Aging resistance
  • Amorphization
  • Surface modification
  • Symmetrical structure

TRAF3

TRAF3, a Target of MicroRNA-363-3p, Suppresses Senescence and Regulates the Balance Between Osteoblastic and Adipocytic Differentiation of Rat Bone Marrow-Derived Mesenchymal Stem Cells.


Keywords

  • TRAF3
  • adipogenic differentiation
  • bone marrow-derived mesenchymal stem cells
  • miR-363-3p
  • osteogenic differentiation
  • senescence

TREM2

Loss of TREM2 Confers Resilience to Synaptic and Cognitive Impairment in Aged Mice.


Keywords

  • TREM2
  • aging
  • dendritic spine density
  • learning and memory
  • long-term potentiation
  • synaptic plasticity


Triggering Receptor Expressed on Myeloid Cell 2 R47H Exacerbates Immune Response in Alzheimer's Disease Brain.


Keywords

  • NKG2D ligands
  • aging
  • inflammation
  • interferon type I response
  • microglia
  • neurodegeneration
  • senescence


Knockdown of astrocytic TREM2 in the hippocampus relieves cognitive decline in elderly male mice.


Keywords

  • Aging
  • Long-term potentiation
  • TREM2
  • astrocytes
  • learning and memory

TRIM21

TRIM21 overexpression promotes tumor progression by regulating cell proliferation, cell migration and cell senescence in human glioma.


Keywords

  • Glioma
  • TRIM21
  • cell senescence
  • drug resistance
  • p53-p21 pathway
  • prognosis

TRIM27

TRIM27 Functions as a Novel Oncogene in Non-Triple-Negative Breast Cancer by Blocking Cellular Senescence through p21 Ubiquitination.


Keywords

  • EP300
  • TRIM27
  • breast cancer
  • cell apoptosis
  • cell senescence
  • chemoresistance
  • p21
  • prognosis
  • transcription
  • ubiquitination

TRIP13

BubR1 allelic effects drive phenotypic heterogeneity in mosaic-variegated aneuploidy progeria syndrome.


MeSH Terms

  • Aging
  • Alleles
  • Animals
  • Cell Cycle Proteins
  • Chromosome Disorders
  • Lung Neoplasms
  • Mice
  • Mice, Inbred C57BL
  • Mitosis
  • Mosaicism
  • Mutation
  • Phenotype
  • Progeria
  • Protein-Serine-Threonine Kinases

Keywords

  • Aging
  • Cancer
  • Cellular senescence
  • Genetic diseases
  • Oncology

TRPC6

Redox and mTOR-dependent regulation of plasma lamellar calcium influx controls the senescence-associated secretory phenotype.


Keywords

  • SASP
  • Senescence
  • TRPC6
  • calcium
  • hydrogen peroxide
  • mTOR

TRPC7

Nociceptive transient receptor potential canonical 7 (TRPC7) mediates aging-associated tumorigenesis induced by ultraviolet B.


Keywords

  • TRPC7
  • aging
  • p53
  • tumor initiator gene
  • tumorigenesis
  • ultraviolet pathology

TRPV4

TRPV4 receptor as a functional sensory molecule in bladder urothelium: Stretch-independent, tissue-specific actions and pathological implications.


MeSH Terms

  • Animals
  • Calcium
  • Guinea Pigs
  • Humans
  • Muscle Contraction
  • Muscle, Smooth
  • TRPV Cation Channels
  • Urinary Bladder
  • Urothelium

Keywords

  • ATP release
  • TRPV4 receptor
  • aging
  • overactive bladders
  • urothelium


Exercise restores impaired endothelium-derived hyperpolarizing factor-mediated vasodilation in aged rat aortic arteries via the TRPV4-K 2.3 signaling complex.


MeSH Terms

  • Animals
  • Biological Factors
  • Cardiovascular Diseases
  • Endothelial Cells
  • Endothelium, Vascular
  • Male
  • Potassium Channels, Calcium-Activated
  • Rats
  • Rats, Sprague-Dawley
  • TRPV Cation Channels
  • Vasodilation

Keywords

  • EDHF
  • KCa2.3
  • TRPV4
  • aging
  • endothelium
  • exercise

TSPO

Age and Sex Influence the Neuro-inflammatory Response to a Peripheral Acute LPS Challenge.


Keywords

  • 18 kDa translocator protein
  • aging
  • astrocytes
  • microglia
  • neuroinflammation
  • triggering receptor expressed on myeloid cells 2


Upregulation of cannabinoid receptor type 2, but not TSPO, in senescence-accelerated neuroinflammation in mice: a positron emission tomography study.


MeSH Terms

  • Aging
  • Animals
  • Brain
  • Inflammation
  • Mice
  • Microglia
  • Positron-Emission Tomography
  • Radiopharmaceuticals
  • Receptor, Cannabinoid, CB2
  • Receptors, GABA
  • Up-Regulation

Keywords

  • Cannabinoid receptor type 2
  • Immunostaining
  • Microglial activation
  • Positron emission tomography
  • Senescence-accelerated prone mouse
  • Translocator protein

TST

H S Donors Reverse Age-Related Gastric Malfunction Impaired Due to Fructose-Induced Injury [i]via[/i] CBS, CSE, and TST Expression.


Keywords

  • aging
  • donor
  • fructose
  • gastric mucosa
  • hydrogen sulfide
  • oxidative stress


Adaptations in mechanical muscle function, muscle morphology, and aerobic power to high-intensity endurance training combined with either traditional or power strength training in older adults: a randomized clinical trial.


Keywords

  • Aging
  • Concurrent training
  • Explosive force
  • Functional capacity
  • HIIT


Digital phenotyping by consumer wearables identifies sleep-associated markers of cardiovascular disease risk and biological aging.


MeSH Terms

  • Adult
  • Aged
  • Aging
  • Body Mass Index
  • Cardiovascular Diseases
  • Cohort Studies
  • Female
  • Humans
  • Male
  • Middle Aged
  • Risk Factors
  • Self Report
  • Sleep
  • Telomere
  • Waist Circumference
  • Wearable Electronic Devices
  • Young Adult

Keywords

  • Data integration
  • Predictive markers
  • Risk factors
  • Senescence


Objective Sleep Duration in Older Adults: Results From The Irish Longitudinal Study on Ageing.


MeSH Terms

  • Accelerometry
  • Aged
  • Aging
  • Cross-Sectional Studies
  • Exercise
  • Female
  • Health Status
  • Humans
  • Independent Living
  • Ireland
  • Longitudinal Studies
  • Male
  • Polysomnography
  • Self Report
  • Sleep
  • Time Factors

Keywords

  • GENEActiv
  • accelerometer
  • actigraphy
  • older population
  • sleep duration

TTL

Longitudinal Associations of Body Mass Index, Waist Circumference, and Waist-to-Hip Ratio with Biomarkers of Oxidative Stress in Older Adults: Results of a Large Cohort Study.


MeSH Terms

  • Aged
  • Aged, 80 and over
  • Aging
  • Biomarkers
  • Body Mass Index
  • Cohort Studies
  • Female
  • Germany
  • Humans
  • Longitudinal Studies
  • Male
  • Middle Aged
  • Oxidative Stress
  • Waist Circumference
  • Waist-Hip Ratio

Keywords

  • Body mass index
  • Free radicals
  • Oxidative stress
  • Reactive oxygen metabolites
  • Total thiol levels
  • Waist circumference
  • Waist-to-hip ratio

TTN

LncRNA TTN-AS1 regulates osteosarcoma cell apoptosis and drug resistance via the miR-134-5p/MBTD1 axis.


MeSH Terms

  • Aging
  • Apoptosis
  • Brain Neoplasms
  • Cell Line, Tumor
  • Cell Proliferation
  • Chromosomal Proteins, Non-Histone
  • Computational Biology
  • Drug Resistance
  • Gene Expression Regulation, Neoplastic
  • Humans
  • MicroRNAs
  • Osteosarcoma
  • RNA, Long Noncoding

Keywords

  • aging and age-related diseases
  • lncRNA TTN-AS1
  • malignant brain tumour domain containing protein 1
  • miR-134-5p
  • osteosarcoma
  • resistance

TTR

Cellular secretion and cytotoxicity of transthyretin mutant proteins underlie late-onset amyloidosis and neurodegeneration.


MeSH Terms

  • Amyloid Neuropathies, Familial
  • Animals
  • Cell Death
  • Cell Line, Tumor
  • Disease Models, Animal
  • Drosophila
  • HEK293 Cells
  • Humans
  • Locomotion
  • Longevity
  • Mutant Proteins
  • Mutation
  • Nerve Degeneration
  • Prealbumin

Keywords

  • Amyloidosis
  • Drosophila melanogaster
  • ERQC
  • Endoplasmic reticulum quality control
  • Proteostasis
  • TTR
  • Transthyretin

TXNIP

Panax notoginseng saponins attenuate neuroinflammation through TXNIP-mediated NLRP3 inflammasome activation in aging rats.


Keywords

  • Aging
  • Microglia
  • NLRP3 inflammasome
  • Saponins from Panax notoginseng.
  • TXNIP
  • neuroinflammation


Redox homeostasis and cell cycle activation mediate beta-cell mass expansion in aged, diabetes-prone mice under metabolic stress conditions: Role of thioredoxin-interacting protein (TXNIP).


Keywords

  • Aging
  • Beta-cells
  • Cell cycle
  • Metabolic stress
  • Redox homeostasis
  • Thioredoxin-interacting protein


[Effect of diabetic induced thioredoxin interacting protein (TXNIP) on islet cell senescence].


MeSH Terms

  • Animals
  • Carrier Proteins
  • Cellular Senescence
  • Diabetes Mellitus, Experimental
  • Islets of Langerhans
  • Mice
  • Thioredoxins

Keywords

  • INS-1 cell
  • cell senescence
  • diabetes
  • thioredoxin interacting protein


PRMT5-TRIM21 interaction regulates the senescence of osteosarcoma cells by targeting the TXNIP/p21 axis.


Keywords

  • PRMT5
  • TRIM21
  • TXNIP
  • p21
  • senescence

TXNRD2

Wogonin induces cellular senescence in breast cancer via suppressing TXNRD2 expression.


Keywords

  • Breast cancer
  • Immune surveillance
  • ROS
  • Senescence
  • TXNRD2
  • Wogonin

U2AF1

Isobaric tags for relative and absolute quantitation (iTRAQ)-based proteomic analysis of mRNA splicing relevant proteins in aging HSPCs.


Keywords

  • Aging
  • DEPs
  • HSPC
  • iTRAQ
  • mRNA splicing

UACA

Knockdown of [i]UACA[/i] inhibitsproliferation and invasion and promotes senescence of hepatocellular carcinoma cells.


Keywords

  • HIF1α
  • UACA
  • hepatocellular carcinoma
  • invasion
  • knockdown
  • proliferation
  • senescence

UCHL1

Abolishing UCHL1's hydrolase activity exacerbates TBI-induced axonal injury and neuronal death in mice.


Keywords

  • Aging
  • Axonal injury
  • Neurodegeneration
  • Traumatic brain injury
  • Ubiquitin carboxy terminal hydrolase L1
  • Ubiquitin proteasome pathway

UCP1

Muscle-dependent regulation of adipose tissue function in long-lived growth hormone-mutant mice.


Keywords

  • adipose tissue
  • aging
  • growth hormone
  • inflammation
  • uncoupling protein 1 (UCP1)


Lack of UCP1 stimulates fatty liver but mediates UCP1-independent action of beige fat to improve hyperlipidemia in Apoe knockout mice.


Keywords

  • Apoe knockout mice
  • Beige fat
  • Gene expression
  • Hyperlipidemia
  • Longevity
  • Uncoupling protein 1


Postnatal leptin surge is critical for the transient induction of the developmental beige adipocytes in mice.


MeSH Terms

  • Adipocytes, Beige
  • Adipocytes, White
  • Adipose Tissue
  • Aging
  • Animals
  • Dose-Response Relationship, Drug
  • Female
  • Leptin
  • Male
  • Mice
  • Mice, Obese
  • Sympathetic Nervous System
  • Tyrosine 3-Monooxygenase
  • Uncoupling Protein 1

Keywords

  • beige adipocytes
  • leptin
  • sympathetic nerve system


Age-related sex differences in the expression of important disease-linked mitochondrial proteins in mice.


MeSH Terms

  • Adipose Tissue, Brown
  • Aging
  • Animals
  • Brain
  • Female
  • Male
  • Mice, Inbred C57BL
  • Mitochondrial Proteins
  • Muscle, Skeletal
  • Sex Characteristics
  • Spleen


An anti-inflammatory phenotype in visceral adipose tissue of old lean mice, augmented by exercise.


MeSH Terms

  • Adipocytes
  • Aging
  • Animals
  • Humans
  • Inflammation
  • Intra-Abdominal Fat
  • Macrophages
  • Mice
  • Obesity
  • Phenotype
  • Physical Conditioning, Animal
  • Resistance Training

UGT2B28

Ages of hepatocellular carcinoma occurrence and life expectancy are associated with a UGT2B28 genomic variation.


MeSH Terms

  • Adult
  • Age of Onset
  • Aged
  • Aged, 80 and over
  • Carcinoma, Hepatocellular
  • Female
  • Genetic Association Studies
  • Genetic Predisposition to Disease
  • Glucuronosyltransferase
  • Humans
  • Life Expectancy
  • Liver Neoplasms
  • Male
  • Middle Aged
  • Neoplasm Metastasis
  • Neoplasm Recurrence, Local
  • Odds Ratio
  • Polymorphism, Single Nucleotide
  • Survival Analysis
  • Young Adult

Keywords

  • Alcoholism
  • Xenobiotic metabolizing enzymes
  • Young hepatocellular carcinoma; age of death

USP7

Deubiquitinase USP7 regulates [i]Drosophila[/i] aging through ubiquitination and autophagy.


Keywords

  • DMC
  • Drosophila
  • USP7
  • aging
  • autophagy

VCAM1

Sunitinib facilitates metastatic breast cancer spreading by inducing endothelial cell senescence.


Keywords

  • Cell senescence
  • Metastasis
  • Metastatic breast cancer (MBC)
  • Receptor tyrosine kinase (RTK)
  • Sunitinib

VDAC1

Low abundance of NDUFV2 and NDUFS4 subunits of the hydrophilic complex I domain and VDAC1 predicts mammalian longevity.


Keywords

  • Complex I
  • Droplet digital PCR
  • Longevity
  • Mammals
  • Mitochondria
  • NDUFS4 subunit
  • NDUFV2 subunit
  • VDAC
  • Western blot


Changes in the expression of oxidative phosphorylation complexes in the aging intestinal mucosa.


Keywords

  • Aging
  • Colonic crypt
  • Expression
  • Intestine
  • Mitochondria
  • OXPHOS

VDR

25-Hydroxyvitamin D positively regulates periodontal inflammaging via SOCS3/STAT signaling in diabetic mice.


Keywords

  • 25-Hydroxyvitamin D(3)
  • Diabetic periodontitis
  • Inflammaging
  • SOCS3
  • Senescence
  • Senescence-associated secretory phenotypes


1,25-Dihydroxyvitamin D protects against age-related osteoporosis by a novel VDR-Ezh2-p16 signal axis.


MeSH Terms

  • 25-Hydroxyvitamin D3 1-alpha-Hydroxylase
  • Aging
  • Animals
  • Bone and Bones
  • Cells, Cultured
  • Cyclin-Dependent Kinase Inhibitor p16
  • Cyclin-Dependent Kinase Inhibitor p19
  • DNA Damage
  • Enhancer of Zeste Homolog 2 Protein
  • Female
  • Histones
  • Male
  • Mesenchymal Stem Cells
  • Mice
  • Mice, Knockout
  • Osteocytes
  • Osteogenesis
  • Osteoporosis
  • Oxidative Stress
  • Receptors, Calcitriol
  • Vitamin D

Keywords

  • Ezh2
  • Vitamin D
  • cellular senescence
  • osteogenesis
  • osteoporosis
  • p16


Active vitamin D impedes the progression of non-alcoholic fatty liver disease by inhibiting cell senescence in a rat model.


Keywords

  • Active vitamin D
  • Cell senescence
  • Non-alcoholic fatty liver disease
  • Oxidative stress
  • P53-p21 signaling pathway
  • Vitamin D receptor

VEGFA

APOE ε4-specific associations of VEGF gene family expression with cognitive aging and Alzheimer's disease.


MeSH Terms

  • Aged
  • Aged, 80 and over
  • Aging
  • Apolipoprotein E4
  • Cognitive Aging
  • Cognitive Dysfunction
  • Female
  • Gene Expression
  • Genetic Association Studies
  • Genetic Predisposition to Disease
  • Genotype
  • Humans
  • Male
  • Neovascularization, Physiologic
  • Neuropilin-1
  • Vascular Endothelial Growth Factor A

Keywords

  • APOE-ε4
  • Aging
  • Cognition
  • Gene expression
  • Vascular endothelial growth factor (VEGF)

VGLL4

The lncRNA MEG3/miR-16-5p/VGLL4 regulatory axis is involved in etoposide-induced senescence of tumor cells.


Keywords

  • LncRNA MEG3
  • breast cancer
  • cell senescence
  • etoposide
  • lung adenocarcinoma

VHL

Hypoxic response regulators RHY-1 and EGL-9/PHD promote longevity through a VHL-1-independent transcriptional response.


Keywords

  • Aging
  • C. elegans
  • EGL-9/PHD
  • HIF-1 signaling
  • Hypoxic response
  • Lifespan
  • RHY-1

VIM

Establishment and characterization of a fibroblast cell line from postmortem skin of an adult Chinese muntjac (Muntiacus reevesi).


MeSH Terms

  • Aging
  • Animals
  • Cell Culture Techniques
  • Cell Line
  • Cell Proliferation
  • Cell Shape
  • Chromosomes, Mammalian
  • Fibroblasts
  • Male
  • Muntjacs
  • Postmortem Changes
  • Skin

Keywords

  • Characteristics
  • Chinese muntjac
  • Fibroblast cell line
  • Postmortem skin

VIP

Alterations in Intrinsic and Synaptic Properties of Hippocampal CA1 VIP Interneurons During Aging.


Keywords

  • VIP
  • action potential
  • aging
  • calretinin
  • circuit disinhibition
  • hippocampus
  • synapse


Nutrition and exercise interventions could ameliorate age-related cognitive decline: a meta-analysis of randomized controlled trials.


Keywords

  • Aging
  • Cognitive impairment
  • Exercise
  • Meta-analysis
  • Nutrition

VSIG4

Immune checkpoint protein VSIG4 as a biomarker of aging in murine adipose tissue.


Keywords

  • VSIG4
  • adipose tissue
  • aging
  • frailty index
  • immune checkpoint
  • inflammation
  • macrophage
  • mouse

WASL

Loss of Wasl improves pancreatic cancer outcome.


Keywords

  • Cancer
  • Cellular senescence
  • Mouse models
  • Oncology

WDR5

Inhibition of the H3K4 methyltransferase MLL1/WDR5 complex attenuates renal senescence in ischemia reperfusion mice by reduction of p16 .


MeSH Terms

  • Acute Kidney Injury
  • Animals
  • Biphenyl Compounds
  • Cell Line
  • Cyclin-Dependent Kinase Inhibitor p16
  • Dihydropyridines
  • Drug Evaluation, Preclinical
  • Fibroblasts
  • Histone-Lysine N-Methyltransferase
  • Histones
  • Intracellular Signaling Peptides and Proteins
  • Male
  • Mice, Inbred C57BL
  • Myeloid-Lymphoid Leukemia Protein
  • Rats
  • Renal Insufficiency
  • Reperfusion Injury

Keywords

  • H3K4me3
  • MLL1
  • WDR5
  • acute kidney injury
  • p16(INK4a)
  • senescence

WFDC2

Differences in biomarkers and molecular pathways according to age for patients with HFrEF.


Keywords

  • aging
  • biological age
  • biomarkers
  • chronological age
  • heart failure with reduced ejection fraction

WIPI2

Neuronal autophagy declines substantially with age and is rescued by overexpression of WIPI2.


MeSH Terms

  • Aging
  • Animals
  • Autophagy
  • Autophagy-Related Proteins
  • Mice, Transgenic
  • Models, Biological
  • Neurons
  • Phagosomes
  • Phosphate-Binding Proteins
  • RNA, Messenger

Keywords

  • Aging
  • WIPI2
  • autophagosome biogenesis
  • autophagy
  • macroautophagy
  • neurodegeneration
  • neuronal autophagy

WNT1

Plasma proteomic profile of age, health span, and all-cause mortality in older adults.


Keywords

  • SomaScan® assay
  • aging
  • proteomics
  • weighted gene co-expression network analysis

WNT10A

Dysregulation of the Wnt Signaling Pathway and Synovial Stem Cell Dysfunction in Osteoarthritis Development.


Keywords

  • Wnt signaling pathway
  • cell senescence
  • differentiation
  • osteoarthritis
  • synovial mesenchymal stem cells (SMSCs)

WNT3A

Chronic WNT/β-catenin signaling induces cellular senescence in lung epithelial cells.


Keywords

  • ATII cells
  • Aging
  • Cellular senescence
  • IPF
  • WNT signaling

WNT7A

Exogenous Expression of WNT7A in Leukemia-Derived Cell Lines Induces Resistance to Chemotherapeutic Agents.


Keywords

  • WNT signaling
  • WNT7A
  • cell cycle
  • chemotherapeutic agents
  • leukemias
  • senescence

WRN

The Impact of Vitamin C on Different System Models of Werner Syndrome.


Keywords

  • Werner syndrome
  • aging
  • mouse
  • stem cells
  • vitamin C
  • worm


WRN modulates translation by influencing nuclear mRNA export in HeLa cancer cells.


Keywords

  • Cancer
  • NXF1 export receptor
  • Senescence
  • Translation
  • Werner syndrome protein
  • mRNA export


MIB1-mediated degradation of WRN promotes cellular senescence in response to camptothecin treatment.


Keywords

  • CPT
  • Mind bomb 1
  • Werner syndrome protein
  • aging
  • protein stability


A Case Report of Werner's Syndrome With a Novel Mutation From India.


Keywords

  • aging
  • novel mutation
  • progeria
  • werner syndrome
  • wrn gene


Evidence for premature aging in a Drosophila model of Werner syndrome.


MeSH Terms

  • Aging, Premature
  • Animals
  • Behavior, Animal
  • Body Composition
  • Body Weight
  • DNA Repair
  • Drosophila
  • Drosophila Proteins
  • Exonucleases
  • Female
  • Gastrointestinal Neoplasms
  • Male
  • Motor Activity
  • Muscle Weakness
  • Mutation
  • Phenotype
  • Werner Syndrome

Keywords

  • Aging
  • DNA repair
  • Locomotor function
  • Tumor
  • Werner syndrome

WT1

Age and weight at first mating affects plasma leptin concentration but no effects on reproductive performance of gilts.


Keywords

  • Backfat
  • Gilts
  • Leptin
  • Litter performance
  • Longevity
  • Mating

WWP1

The ubiquitin ligase WWP1 contributes to shifts in matrix proteolytic profiles and a myocardial aging phenotype with diastolic heart.


MeSH Terms

  • Age Factors
  • Animals
  • Cells, Cultured
  • Diastole
  • Disease Models, Animal
  • Extracellular Matrix
  • Female
  • Fibroblasts
  • Heart Failure
  • Hypertrophy, Left Ventricular
  • Male
  • Mice, Inbred C57BL
  • Mice, Transgenic
  • Myocardium
  • Phenotype
  • Proteolysis
  • Stroke Volume
  • Ubiquitin-Protein Ligases
  • Ventricular Dysfunction, Left
  • Ventricular Function, Left
  • Ventricular Remodeling

Keywords

  • aging
  • cardiac hypertrophy
  • diastolic dysfunction
  • heart failure
  • ventricular remodeling

XBP1

Age-dependent impairment of adipose-derived stem cells isolated from horses.


Keywords

  • Aging
  • Endoplasmic reticulum stress
  • Equine adipose-derived mesenchymal stem cells
  • Insulin resistance
  • Pro-inflammatory cytokines

XDH

Enhancing xanthine dehydrogenase activity is an effective way to delay leaf senescence and increase rice yield.


Keywords

  • Allantoin
  • Reactive oxygen species
  • Rice (Oryza sativa L.)
  • Senescence
  • Xanthine dehydrogenase
  • Yield

ZC3H12A

Keratinocyte-specific ablation of Mcpip1 impairs skin integrity and promotes local and systemic inflammation.


MeSH Terms

  • Aging
  • Animals
  • Calgranulin A
  • Cell Differentiation
  • Cell Proliferation
  • Cells, Cultured
  • Cornified Envelope Proline-Rich Proteins
  • Epidermis
  • Gene Expression Regulation
  • Gene Ontology
  • Inflammation
  • Interleukin-1
  • Keratinocytes
  • Keratins
  • Lymph Nodes
  • Mice
  • Mice, Inbred C57BL
  • Mice, Transgenic
  • Proliferating Cell Nuclear Antigen
  • Ribonucleases
  • Skin
  • Spleen
  • Transcriptome

Keywords

  • MCPIP1
  • Regnase-1
  • Skin inflammation
  • ZC3H12A

ZEB2

miR-200b regulates cellular senescence and inflammatory responses by targeting ZEB2 in pulmonary emphysema.


MeSH Terms

  • Animals
  • Cell Line
  • Cellular Senescence
  • Disease Models, Animal
  • Gene Expression
  • Gene Expression Regulation
  • Inflammation
  • Lung
  • Mice
  • MicroRNAs
  • Pulmonary Emphysema
  • Zinc Finger E-box Binding Homeobox 2

Keywords

  • ZEB2
  • cellular senescence
  • inflammation
  • miR-200b
  • pulmonary emphysema

ZMPSTE24

Bone marrow-derived mesenchymal stem cells in three-dimensional co-culture attenuate degeneration of nucleus pulposus cells.


MeSH Terms

  • Bone Marrow Cells
  • Cell Cycle
  • Cell Proliferation
  • Cell Survival
  • Cells, Cultured
  • Cellular Senescence
  • Coculture Techniques
  • Collagen Type II
  • Female
  • Humans
  • Intervertebral Disc Degeneration
  • Male
  • Matrix Metalloproteinase 9
  • Membrane Proteins
  • Mesenchymal Stem Cells
  • Metalloendopeptidases
  • Middle Aged
  • Nucleus Pulposus
  • Signal Transduction
  • Transcription Factor RelA
  • Up-Regulation
  • beta-Galactosidase

Keywords

  • 3D co-culture
  • ZMPSTE24
  • bone marrow-derived mesenchymal stem cells
  • nucleus pulposus
  • senescence