Публикации о генах и старении (titles): различия между версиями

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__NOTOC__


==ACE2==
==A2M==


{{medline-entry
{{medline-entry
|title=How Does SARS-CoV-2 Affect the Central Nervous System? A Working Hypothesis.
|title=Age-Dependent Variation in Glycosylation Features of Alpha-2-Macroglobulin.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/33304284
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31489526
|abstract=Interstitial pneumonia was the first manifestation to be recognized as caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2); however, in just a few weeks, it became clear that the coronavirus disease-2019 (COVID-19) overrun tissues and more body organs than just the lungs, so much so that it could be considered a systemic pathology. Several studies reported the involvement of the conjunctiva, the gut, the heart and its pace, and vascular injuries such as thromboembolic complications and Kawasaki disease in children and toddlers were also described. More recently, it was reported that in a sample of 214 SARS-CoV-2 positive patients, 36.4% complained of neurological symptoms ranging from non-specific manifestations (dizziness, headache, and seizures), to more specific symptoms such hyposmia or hypogeusia, and stroke. Older individuals, especially males with comorbidities, appear to be at the highest risk of developing such severe complications related to the Central Nervous System (CNS) involvement. Neuropsychiatric manifestations in COVID-19 appear to develop in patients with and without pre-existing neurological disorders. Growing evidence suggests that SARS-CoV-2 binds to the human Angiotensin-Converting Enzyme 2 ([[ACE2]]) for the attachment and entrance inside host cells. By describing [[ACE2]] and the whole Renin Angiotensin Aldosterone System (RAAS) we may better understand whether specific cell types may be affected by SARS-CoV-2 and whether their functioning can be disrupted in case of an infection. Since clear evidences of neurological interest have already been shown, by clarifying the topographical distribution and density of [[ACE2]], we will be able to speculate how SARS-CoV-2 may affect the CNS and what is the pathogenetic mechanism by which it contributes to the specific clinical manifestations of the disease. Based on such evidences, we finally hypothesize the process of SARS-CoV-2 invasion of the CNS and provide a possible explanation for the onset or the exacerbation of some common neuropsychiatric disorders in the elderly including cognitive impairment and Alzheimer disease.


|keywords=* ACE2
|mesh-terms=* Adult
* Alzheimer disease
* Aging
* Ang(1-7)/Mas
* Electrophoresis, Gel, Two-Dimensional
* COVID-19
* Glycosylation
* RAAS
* Humans
* SARS-CoV
* Infant, Newborn
* brain aging
* Polysaccharides
* neurodegenerative and psychiatric disorders abstract
* Pregnancy-Associated alpha 2-Macroglobulins
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7701095
* Protein Isoforms
* Umbilical Cord
|keywords=* Alpha-2-macroglobulin
* Glycosylation
* Newborn
* Plasma
|full-text-url=https://sci-hub.do/10.1007/s12013-019-00883-4
}}
}}
==ADH5==
==AACS==


{{medline-entry
{{medline-entry
|title=Can Serum Nitrosoproteome Predict Longevity of Aged Women?
|title=Sex differences in subjective age-associated changes in sleep: a prospective elderly cohort study.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/33260845
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/33170149
|abstract=Aging is characterized by increase in reactive oxygen (ROS) and nitrogen (RNS) species, key factors of cardiac failure and disuse-induced muscle atrophy. This study focused on serum nitroproteome as a trait of longevity by adopting two complementary gel-based techniques: two-dimensional differential in gel electrophoresis (2-D DIGE) and Nitro-DIGE coupled with mass spectrometry of albumin-depleted serum of aged (A, [i]n[/i] = 15) and centenarian (C, [i]n[/i] = 15) versus young females (Y, [i]n[/i] = 15). Results indicate spots differently expressed in A and C compared to Y and spots changed in A vs. C. Nitro-DIGE revealed nitrosated protein spots in A and C compared to Y and spots changed in A vs. C only ([i]p[/i]-value < 0.01). Nitro-proteoforms of alpha-1-antitripsin (SERPINA1), alpha-1-antichimotripsin (SERPINA3), ceruloplasmin (CP), 13 proteoforms of haptoglobin (HP), and inactive glycosyltransferase 25 family member 3 (CERCAM) increased in A vs. Y and C. Conversely, nitrosation levels decreased in C vs. Y and A, for immunoglobulin light chain 1 (IGLC1), serotransferrin (TF), transthyretin (TTR), and vitamin D-binding protein (VDBP). Immunoblottings of alcohol dehydrogenase 5/S-nitrosoglutathione reductase ([[ADH5]]/GSNOR) and thioredoxin reductase 1 (TRXR1) indicated lower levels of [[ADH5]] in A vs. Y and C, whereas TRXR1 decreased in A and C in comparison to Y. In conclusion, the study identified putative markers in C of healthy aging and high levels of [[ADH5]]/GSNOR that can sustain the denitrosylase activity, promoting longevity.
 


|keywords=* aging
|keywords=* aging
* cardiovascular disease
* longitudinal studies
* muscle atrophy
* normative
* nitrosative stress
* self-report
* proteomics
* sex characteristics
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7731247
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7695390
}}
}}
==AIP==
==ABCG2==


{{medline-entry
{{medline-entry
|title=[Aryl hydrocarbon receptor interacting protein ([[AIP]]) in human dermis during aging.]
|title=Contribution of senescence in human endometrial stromal cells during proliferative phase to embryo receptivity†.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/33280328
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32285109
|abstract=The aim of this work was to examine the content of aryl hydrocarbon receptor interacting protein ([[AIP]]) in fibroblasts of human dermis from 20 weeks of pregnancy until 85 years old, and defining of a role of [[AIP]] in age-dependent changes in the number of fibroblasts in the dermis. [[AIP]], proliferating cells nuclear antigen (PCNA) were detected with indirect immunohistochemical technique. Results showed that a portion of fibroblasts with positive staining for [[AIP]] in the dermis is gradually increased from 20 weeks of pregnancy until 85 years old. A total number and percent of PCNA positive fibroblasts in dermis decreased with progression of age. Most sufficient age-dependent reduction in a total and PCNA positive number of dermal fibroblast was observed from antenatal until 40 years of life. Correlation analysis showed that both age-dependent decrease in the number of fibroblasts and retardation of their proliferation are significantly associated with age-related increase in the number of [[AIP]] positive fibroblasts in dermis. Results allow to suggest that [[AIP]] is involved in age-dependent decrease in the number and proliferation of fibroblasts in human dermis.


|keywords=* AIP
* PCNA
* aging
* fibroblasts
* skin


|keywords=* cellular senescence
* embryo receptivity
* endometrial stem cell
* human endometrial stromal cell
* infertility
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7313258
}}
}}
==ALAS1==
{{medline-entry
{{medline-entry
|title=Heterozygous disruption of [[ALAS1]] in mice causes an accelerated age-dependent reduction in free heme, but not total heme, in skeletal muscle and liver.
|title=[[ABCG2]] rs2231142 variant in hyperuricemia is modified by SLC2A9 and SLC22A12 polymorphisms and cardiovascular risk factors in an elderly community-dwelling population.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/33307066
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32183743
|abstract=5-Aminolevulinic acid (ALA) is the rate-limiting intermediate in heme biosynthesis in vertebrate species; a reaction catalyzed by the mitochondrial ALA synthase 1 ([[ALAS1]]) enzyme. Previously we reported that knockdown of the ubiquitously expressed [[ALAS1]] gene in mice disrupts normal glucose metabolism, attenuates mitochondrial function and results in a prediabetic like phenotype when animals pass 20-weeks of age (Saitoh et al., 2018). Contrary to our expectations, the cytosolic and mitochondrial heme content of [[ALAS1]] heterozygous (A1+/-) mice were similar to WT animals. Therefore, we speculated that regulatory "free heme" may be reduced in an age dependent manner in A1 ± mice, but not total heme. Here, we examine free and total heme from the skeletal muscle and liver of WT and A1 ± mice using a modified acetone extraction method and examine the effects of aging on free heme by comparing the amounts at 8-12 weeks and 30-36 weeks of age, in addition to the mRNA abundance of [[ALAS1]]. We found an age-dependent reduction in free heme in the skeletal muscle and liver of A1 ± mice, while WT mice showed only a slight decrease in the liver. Total heme levels showed no significant difference between young and aged WT and A1 ± mice. [[ALAS1]] mRNA levels showed an age-dependent reduction similar to that of free heme levels, indicating that [[ALAS1]] mRNA expression levels are a major determinant for free heme levels. The free heme pools in skeletal muscle tissue were almost 2-fold larger than that of liver tissue, suggesting that the heme pool varies across different tissue types. The expression of heme oxygenase 1 (HO-1) mRNA, which is expressed proportionally to the amount of free heme, were similar to those of free heme levels. Taken together, this study demonstrates that the free heme pool differs across tissues, and that an age-dependent reduction in free heme levels is accelerated in mice heterozygous for [[ALAS1]], which could account for the prediabetic phenotype and mitochondrial abnormality observed in these animals.


|keywords=* 5-Aminolevulinate synthase 1 (ALAS1)
|mesh-terms=* ATP Binding Cassette Transporter, Subfamily G, Member 2
* 5-Aminolevulinic acid (ALA)
* Aged
* Aged, 80 and over
* Aging
* Aging
* Free heme
* Cardiovascular Diseases
* Liver
* China
* Skeletal muscle
* Cohort Studies
|full-text-url=https://sci-hub.do/10.1016/j.abb.2020.108721
* Effect Modifier, Epidemiologic
* Epistasis, Genetic
* Female
* Genes, Modifier
* Genetic Predisposition to Disease
* Genome-Wide Association Study
* Glucose Transport Proteins, Facilitative
* Humans
* Hyperuricemia
* Independent Living
* Male
* Neoplasm Proteins
* Organic Anion Transporters
* Organic Cation Transport Proteins
* Polymorphism, Single Nucleotide
* Risk Factors
* Uric Acid
|keywords=* ABCG2
* Hypertension
* Polymorphisms
* Triglyceridemia
* Uric acid
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7077001
}}
}}
==ALB==
==ABL1==


{{medline-entry
{{medline-entry
|title=Effects of Age on Inflammatory Profiles and Nutrition/Energy Metabolism in Domestic Cats.
|title=European LeukemiaNet 2020 recommendations for treating chronic myeloid leukemia.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/33262938
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32127639
|abstract=Animals tend to increase in body weight and body condition score (BCS) with aging. Serum diagnostic markers related to energy metabolism may show changes even in healthy cats with aging. Seventy domestic cats were recruited for this study. Based upon the modified AAFP-AAHA Feline Life Stage Guidelines, animals were divided into six groups: Junior (7 months-2 years), Prime (3 -6 years), Mature (7-10 years), Senior (11-14 years), Geriatric-obese (15 years ≤) and Geriatric-thin (15 years ≤). Their body condition scores (BCS) ranged from 3/9 to 9/9. Changes in metabolites, inflammatory markers, hormone concentrations and enzyme activities related to energy metabolism were investigated in serum of 70 domestic cats of various ages. Serum glucose (GLU) concentrations in the Mature, Senior, and Geriatric-obese groups were significantly higher than those in the Junior group. Serum amyloid A (SAA) concentrations in the Geriatric-thin group were significantly increased compared with the Junior group. SAA concentrations in the Geriatric-obese group tended to increase although there were no statistically significant differences. In the Mature, Senior, Geriatric-obese and Geriatric-thin groups, malate dehydrogenase/lactate dehydrogenase (M/L) ratio, an energy metabolic indicator, tended to decrease compared with the Junior group. In the Senior group, triglyceride (TG) concentrations were significantly increased compared with the Junior group. In the Geriatric-obese and Geriatric-thin groups, blood urea nitrogen (BUN) concentrations were significantly increased compared with the Junior group. In the Geriatric-obese group, albumin ([[ALB]]) concentrations were decreased compared with the Junior group. Aged domestic cats tend to increase in body weight and BCS. In addition, serum GLU, TG, SAA, and BUN concentrations increased and serum [[ALB]] concentrations and M/L ratio decreased. These diagnostic markers may be useful to detect small changes related to energy metabolism with aging that may cause obesity with light inflammation in healthy cats.
 
|mesh-terms=* Aniline Compounds
* Antineoplastic Agents
* Clinical Decision-Making
* Consensus Development Conferences as Topic
* Dasatinib
* Disease Management
* Fusion Proteins, bcr-abl
* Gene Expression
* Humans
* Imatinib Mesylate
* Leukemia, Myelogenous, Chronic, BCR-ABL Positive
* Life Expectancy
* Monitoring, Physiologic
* Nitriles
* Protein Kinase Inhibitors
* Pyrimidines
* Quality of Life
* Quinolines
* Survival Analysis
 
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7214240
}}
==ABO==


|keywords=* M/L ratio
{{medline-entry
* SAA
|title=Allelic distribution of [i][[ABO]][/i] gene in Chinese centenarians.
* aging
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/33103040
* domestic cats
 
* obesity
 
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7695597
|keywords=* ABO gene
* centenarian
* longevity
* single nucleotide polymorphisms
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7574633
}}
}}
==ASB7==
{{medline-entry
{{medline-entry
|title=[[ASB7]] Is a Novel Regulator of Cytoskeletal Organization During Oocyte Maturation.
|title=Genetically Determined [[ABO]] Blood Group and its Associations With Health and Disease.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/33251222
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31969017
|abstract=Ankyrin repeat and SOCS box (ASB) family members have a [i]C[/i]-terminal SOCS box and an [i]N[/i]-terminal ankyrin-related sequence of variable repeats. To date, the roles of ASB family members remain largely unknown. In the present study, by employing knockdown analysis, we investigated the effects of [[ASB7]] on mouse oocyte meiosis. We show that specific depletion of [[ASB7]] disrupts maturational progression and meiotic apparatus. In particular, abnormal spindle, misaligned chromosomes, and loss of cortical actin cap are frequently observed in [[ASB7]]-abated oocytes. Consistent with this observation, incidence of aneuploidy is increased in these oocytes. Meanwhile, confocal scanning reveals that loss of [[ASB7]] impairs kinetochore-microtubule interaction and provokes the spindle assembly checkpoint during oocyte meiosis. Furthermore, we find a significant reduction of [[ASB7]] protein in oocytes from aged mice. Importantly, increasing [[ASB7]] expression is capable of partially rescuing the maternal age-induced meiotic defects in oocytes. Together, our data identify [[ASB7]] as a novel player in regulating cytoskeletal organization and discover the potential effects of [[ASB7]] on quality control of aging oocytes.


|keywords=* ASBs
|mesh-terms=* ABO Blood-Group System
* maternal aging
* Adult
* meiosis
* Age Factors
* oocyte
* Aged
* reproduction
* Cardiovascular Diseases
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7674779
* Female
* Gene Frequency
* Genetic Predisposition to Disease
* Health Status
* Healthy Aging
* Humans
* Incidence
* Male
* Middle Aged
* Phenotype
* Polymorphism, Single Nucleotide
* Prevalence
* Risk Assessment
* Risk Factors
* United Kingdom
|keywords=* ABO
* aging
* blood
* genetics
* hypertension
* phenotype
|full-text-url=https://sci-hub.do/10.1161/ATVBAHA.119.313658
}}
}}
==ATF4==
==ABR==


{{medline-entry
{{medline-entry
|title=Endoplasmic Reticulum Stress Mediates Vascular Smooth Muscle Cell Calcification via Increased Release of Grp78-Loaded Extracellular Vesicles.
|title=[Hidden hearing loss and early identification].
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/33297752
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32791650
|abstract=Vascular calcification is common among aging populations and mediated by vascular smooth muscle cells (VSMCs). The endoplasmic reticulum (ER) is involved in protein folding and ER stress has been implicated in bone mineralization. The role of ER stress in VSMC-mediated calcification is less clear. Approach and Results: mRNA expression of the ER stress markers PERK (PKR (protein kinase RNA)-like ER kinase), ATF (activating transcription factor) 4, ATF6, and Grp78 was detectable in human vessels with levels of PERK decreased in calcified plaques compared to healthy vessels. Protein deposition of Grp78/Grp94 was increased in the matrix of calcified arteries. Induction of ER stress accelerated human primary VSMC-mediated calcification, elevated expression of some osteogenic markers (Runx2, Osterix, ALP, BSP, and OPG), and decreased expression of SMC markers. ER stress potentiated extracellular vesicle (EV) release via SMPD3. EVs from ER stress-treated VSMCs showed increased Grp78 levels and calcification. Electron microscopy confirmed the presence of Grp78/Grp94 in EVs. siRNA knock-down of Grp78 decreased calcification. Warfarin-induced Grp78 and [[ATF4]] expression in rat aortas and VSMCs and increased calcification in an ER stress-dependent manner via increased EV release. ER stress induces vascular calcification by increasing release of Grp78-loaded EVs. Our results reveal a novel mechanism of action of warfarin, involving increased EV release via the PERK-[[ATF4]] pathway, contributing to calcification. This study is the first to show that warfarin induces ER stress and to link ER stress to cargo loading of EVs.


|mesh-terms=* Acoustic Stimulation
* Audiometry, Pure-Tone
* Auditory Threshold
* Evoked Potentials, Auditory, Brain Stem
* Hearing Loss, Noise-Induced
* Humans
* Noise
|keywords=* aging
|keywords=* aging
* arteries
* drug damage
* endoplasmic reticulum
* hidden hearing loss
* vascular calcification
* noise exposure
* warfarin
|full-text-url=https://sci-hub.do/10.13201/j.issn.2096-7993.2020.07.023
|full-text-url=https://sci-hub.do/10.1161/ATVBAHA.120.315506
}}
}}
==ATF6==
{{medline-entry
|title=Aging But Not Age-Related Hearing Loss Dominates the Decrease of Parvalbumin Immunoreactivity in the Primary Auditory Cortex of Mice.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32327469
 


|keywords=* age-related hearing loss
* aging
* mouse primary auditoy cortex
* parvalbumin
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7210488
}}
{{medline-entry
{{medline-entry
|title=Cellular proteostasis decline in human senescence.
|title=Hearing loss through apoptosis of the spiral ganglion neurons in apolipoprotein E knockout mice fed with a western diet.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/33257563
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31948760
|abstract=Proteostasis collapse, the diminished ability to maintain protein homeostasis, has been established as a hallmark of nematode aging. However, whether proteostasis collapse occurs in humans has remained unclear. Here, we demonstrate that proteostasis decline is intrinsic to human senescence. Using transcriptome-wide characterization of gene expression, splicing, and translation, we found a significant deterioration in the transcriptional activation of the heat shock response in stressed senescent cells. Furthermore, phosphorylated HSF1 nuclear localization and distribution were impaired in senescence. Interestingly, alternative splicing regulation was also dampened. Surprisingly, we found a decoupling between different unfolded protein response (UPR) branches in stressed senescent cells. While young cells initiated UPR-related translational and transcriptional regulatory responses, senescent cells showed enhanced translational regulation and endoplasmic reticulum (ER) stress sensing; however, they were unable to trigger UPR-related transcriptional responses. This was accompanied by diminished [[ATF6]] nuclear localization in stressed senescent cells. Finally, we found that proteasome function was impaired following heat stress in senescent cells, and did not recover upon return to normal temperature. Together, our data unraveled a deterioration in the ability to mount dynamic stress transcriptional programs upon human senescence with broad implications on proteostasis control and connected proteostasis decline to human aging.


|keywords=* UPR
|mesh-terms=* Aging
* chaperones
* Animals
* heat shock response
* Apolipoproteins E
* protein homeostasis
* Apoptosis
* senescence
* Diet, Western
|full-text-url=https://sci-hub.do/10.1073/pnas.2018138117
* Disease Models, Animal
* Hearing Loss
* Male
* Mice
* Mice, Inbred C57BL
* Mice, Knockout
* Neurons
* Spiral Ganglion
|keywords=* Apoptosis
* Atherosclerosis
* Hearing loss
* Reactive oxygen specie
* Spiral ganglion neurons
|full-text-url=https://sci-hub.do/10.1016/j.bbrc.2019.12.100
}}
}}
==ATG7==
{{medline-entry
|title=Effects of enriched endogenous omega-3 fatty acids on age-related hearing loss in mice.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31771637


|mesh-terms=* Aging
* Animals
* Body Weight
* Caenorhabditis elegans Proteins
* Cochlea
* Evoked Potentials, Auditory, Brain Stem
* Fatty Acid Desaturases
* Fatty Acids, Omega-3
* Male
* Mice
* Mice, Inbred C57BL
* Mice, Transgenic
* Neurons
* Presbycusis
* Spiral Ganglion
|keywords=* Age-related hearing loss
* C57BL/6 mouse
* Cochlea
* Omega-3 (n-3) fatty acids
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6878677
}}
{{medline-entry
{{medline-entry
|title=Age-related impairment of autophagy in cervical motor neurons.
|title=Hearing impairment and associated morphological changes in pituitary adenylate cyclase activating polypeptide (PACAP)-deficient mice.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/33290859
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31601840
|abstract=Neuromuscular dysfunction is common in old age. Damaged cytoplasmic structures aggregate with aging, especially in post-mitotic cells like motor neurons. Autophagy is a ubiquitous cell process that aids in the clearance of damaged aggregates. Accordingly, we hypothesized that autophagy is impaired in old age, contributing to neuromuscular dysfunction via an effect in motor neurons. Autophagy flux may be impaired as a result of deficits in the initiation, elongation or degradation phases. Changes in the expression levels of core proteins necessary for each of the autophagy phases were evaluated by Western blotting in the cervical spinal cord (segments C2-C6 corresponding to the phrenic motor pool) of adult male and female mice at 6-, 18-, and 24-months of age (reflecting 100%, 90% and 75% survival, respectively). There was no evidence of an effect of age on the expression of the autophagy markers Beclin-1 (Becn-1; initiation), [[ATG7]] and ATG5/12 complex (elongation) or LC3 (elongation/degradation). Reduced p62 expression (a marker of degradation) was evident in the cervical spinal cord of adult mice at 18-months compared to 24-months. Accordingly, expression of LC3 and p62 in motor neurons was analyzed using immunofluorescence and confocal microscopy in separate animals. LC3 and p62 immunoreactivity was evident in the gray matter with minimal expression in the white matter across all age groups. A mixed linear model with animal as a random effect was used to compare relative LC3 and p62 expression in motor neurons to gray matter across age groups. Expression of both LC3 and p62 was higher in choline acetyl transferase (ChAT)-positive motor neurons (~2-3 fold vs. gray matter). Across age groups, there were differences in the relative expression of LC3 (F  = 7.59, p < 0.01) and p62 (F  = 8.00, p < 0.01) in cervical motor neurons. LC3 expression in motor neurons increased ~20% by 24-months of age in both male and female mice. p62 expression in motor neurons increased ~70% by 18-months compared to 6-months with no further changes by 24-months of age in male mice. p62 expression did not change across age groups in female mice, and was ~20% higher than in males. Our findings highlight important changes in autophagy pathways that likely contribute to the development of aging-related neuromuscular dysfunction in mice. At 18-months of age, increased autophagosome clearance (reduced p62 expression) appears to be a global effect not restricted to motor neurons. By 24-months of age, increased expression of LC3 and p62 indicates impaired autophagy with autophagosome accumulation in cervical motor neurons.
 
|mesh-terms=* Aging
* Animals
* Cochlea
* Evoked Potentials, Auditory, Brain Stem
* Genotype
* Hearing
* Hearing Loss
* Inflammation
* Male
* Mice
* Mice, Knockout
* Models, Animal
* Neovascularization, Pathologic
* Neurons
* Pituitary Adenylate Cyclase-Activating Polypeptide
* Proteome
* Proto-Oncogene Proteins c-fos


|keywords=* Aging
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6787024
* Autophagy
}}
* Motor neuron
{{medline-entry
* Neuromuscular dysfunction
|title=Global nurse/midwife workforce and reproductive health through social ecology lens.
* Spinal cord
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31402489
|full-text-url=https://sci-hub.do/10.1016/j.exger.2020.111193
 
|mesh-terms=* Adolescent
* Cross-Sectional Studies
* Employment
* Female
* Global Health
* Health Education
* Humans
* Income
* Life Expectancy
* Male
* Midwifery
* Pregnancy
* Reproductive Health
* Social Environment
* Socioeconomic Factors
* Workforce
|keywords=* global health
* nurse/midwife workforce
* reproductive health
* social ecology
|full-text-url=https://sci-hub.do/10.1111/phn.12648
}}
}}
==BDNF==
==ACD==


{{medline-entry
{{medline-entry
|title=Influence of [i][[BDNF]][/i] Genetic Polymorphisms in the Pathophysiology of Aging-related Diseases.
|title=Genetics of cognitive trajectory in Brazilians: 15 years of follow-up from the Bambuí-Epigen Cohort Study of Aging.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/33269104
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31792241
|abstract=For the first time in history, most of the population has a life expectancy equal or greater than 60 years. By the year 2050, it is expected that the world population in that age range will reach 2000 million, an increase of 900 million with respect to 2015, which poses new challenges for health systems. In this way, it is relevant to analyze the most common diseases associated with the aging process, namely Alzheimer´s disease, Parkinson Disease and Type II Diabetes, some of which may have a common genetic component that can be detected before manifesting, in order to delay their progress. Genetic inheritance and epigenetics are factors that could be linked in the development of these pathologies. Some researchers indicate that the [i][[BDNF]][/i] gene is a common factor of these diseases, and apparently some of its polymorphisms favor the progression of them. In this regard, alterations in the level of [[BDNF]] expression and secretion, due to polymorphisms, could be linked to the development and/or progression of neurodegenerative and metabolic disorders. In this review we will deepen on the different polymorphisms in the [i][[BDNF]][/i] gene and their possible association with age-related pathologies, to open the possibilities of potential therapeutic targets.
 
|mesh-terms=* Age Factors
* Aged
* Aging
* Brazil
* Cognition
* Cognitive Dysfunction
* Cohort Studies
* Female
* Follow-Up Studies
* Genetic Predisposition to Disease
* Genome-Wide Association Study
* Humans
* Male
* Middle Aged
* Polymorphism, Single Nucleotide


|keywords=* Aging
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6889148
* BDNF gene
* aging-related diseases
* polymorphism
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7673859
}}
}}
==BRAF==
==ACE==


{{medline-entry
{{medline-entry
|title=Conditional reprograming culture conditions facilitate growth of lower grade glioma models.
|title=Elite swimmers possess shorter telomeres than recreationally active controls.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/33258947
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/33068677
|abstract=The conditional reprogramming cell culture method was developed to facilitate growth of senescence-prone normal and neoplastic epithelial cells, and involves co-culture with irradiated fibroblasts and the addition of a small molecule Rho kinase (ROCK) inhibitor. The aim of this study was to determine whether this approach would facilitate the culture of compact low grade gliomas. We attempted to culture 4 pilocytic astrocytomas, 2 gangliogliomas, 2 myxopapillary ependymomas, 2 anaplastic gliomas, 2 difficult-to-classify low grade neuroepithelial tumors, a desmoplastic infantile ganglioglioma, and an anaplastic pleomorphic xanthoastrocytoma using a modified conditional reprogramming cell culture approach. Conditional reprogramming resulted in robust increases in growth for a majority of these tumors, with fibroblast conditioned media and ROCK inhibition both required. Switching cultures to standard serum containing media, or serum free neurosphere conditions, with or without ROCK inhibition, resulted in decreased proliferation and induction of senescence markers. ROCK inhibition and conditioned media both promoted Akt and Erk1/2 activation. Several cultures, including one derived from a NF1-associated pilocytic astrocytoma (JHH-NF1-PA1) and one from a [[BRAF]] p.V600E mutant anaplastic pleomorphic xanthoastrocytoma (JHH-PXA1), exhibited growth sufficient for preclinical testing in vitro. In addition, JHH-NF1-PA1 cells survived and migrated in larval zebrafish orthotopic xenografts, while JHH-PXA1 formed orthotopic xenografts in mice histopathologically similar to the tumor from which it was derived. These studies highlight the potential for the conditional reprogramming cell culture method to promote the growth of glial and glioneuronal tumors in vitro, in some cases enabling the establishment of long-term culture and in vivo models.
 


|keywords=* BRAFV600E
|keywords=* Aging
* Conditional reprogramming
* Athlete
* NF1
* Exercise
* Senescence
* Genetics
* low grade glioma
|full-text-url=https://sci-hub.do/10.1016/j.gene.2020.145242
|full-text-url=https://sci-hub.do/10.1093/neuonc/noaa263
}}
}}
==CAD==
{{medline-entry
|title=Coronavirus Disease-2019 Conundrum: RAS Blockade and Geriatric-Associated Neuropsychiatric Disorders.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32850927
 


|keywords=* ACE2
* ACEIs
* ARBs
* COVID-19
* RAS
* SARS-CoV-2
* geriatrics
* neuropsychiatric disorders
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7431869
}}
{{medline-entry
{{medline-entry
|title=Serum soluble Klotho is inversely related to coronary artery calcification assessed by intravascular ultrasound in patients with stable coronary artery disease.
|title=Pregnancy Protects Hyperandrogenemic Female Rats From Postmenopausal Hypertension.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/33303310
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32755410
|abstract=Although the Klotho gene is recognized as an aging-suppressor gene, the clinical significance of its soluble product, soluble Klotho, in coronary artery disease ([[CAD]]) has not been completely determined. The relationship between soluble Klotho and coronary artery calcification (CAC) was investigated in patients with stable [[CAD]]. CAC in culprit lesions was analyzed in 75 non-dialysis patients with stable [[CAD]] who were scheduled for percutaneous coronary intervention (PCI) following intravascular ultrasound (IVUS). The main outcome measure was the calcium index (CalcIndex), a volumetric IVUS-derived measure of total calcification per culprit lesion. A low CalcIndex was defined as a first-quartile calcium index (<0.042). Patients were divided into two groups according to the median serum Klotho value: low Klotho (n = 37, ≤460 pg/mL) and high Klotho (n = 38, >460 pg/mL). The CalcIndex was significantly lower in patients with high than with low Klotho. Patients with high Klotho had a significantly higher prevalence of a low CalcIndex than those with low Klotho. The number of angiographic moderate-severe CACs in whole coronary arteries was significantly decreased in patients with high Klotho compared to low Klotho. Serum Klotho levels correlated significantly and inversely with the CalcIndex. This relationship was pronounced in patients with estimated glomerular filtration rate <60 mL/min/1.73 m . Logistic regression analysis showed that high Klotho was associated with a low CalcIndex independent of classical coronary risk factors and markers of mineral metabolism. High serum soluble Klotho levels are associated with a low degree of CAC in non-dialysis, stable [[CAD]] patients treated by PCI.
 


|keywords=* Aging
|keywords=* aging
* Coronary artery calcification
* endothelin
* Intravascular ultrasound
* menopause
* Klotho
* nitric oxide
|full-text-url=https://sci-hub.do/10.1016/j.jjcc.2020.11.014
* renin-angiotensin system
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7429272
}}
}}
==CCK==
{{medline-entry
|title=Heart failure is associated with accelerated age related metabolic bone disease.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32498656


{{medline-entry
|title=Senolytic agent Quercetin ameliorates intervertebral disc degeneration via the Nrf2/NF-κB axis.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/33242601
|abstract=Intervertebral disc degeneration (IDD) represents major cause of low back pain. Quercetin (QUE) is one of the approved senolytic agents. In this study, we evaluated the protective effects of QUE on IDD development and its underlying mechanism. Effects of senolytic agent QUE on the viability of nucleus pulposus cells (NPCs) were measured by [[CCK]]-8 assays and EdU staining. The senescence associated secreted phenotype (SASP) factors expressions were measured by qPCR, western blot, and ELISA; and NF-κB pathway was detected by immunofluorescence and western blot. Molecular docking was applied to predict the interacting protein of QUE; while Nrf2 was knocked down by siRNAs to confirm its role in QUE regulated senescence phenotype. X-ray, MRI, Hematoxylin-Eosin and Safranin O-Fast green staining were performed to evaluate the therapeutic effects of QUE on IDD in the puncture-induced rat model. In in vitro experiments, QUE inhibited SASP factors expression and senescence phenotype in IL-1β-treated NPCs. Mechanistically, QUE suppressed IL-1β induced activation of the NF-κB pathway cascades; it was also demonstrated in molecular docking and knock down studies that QUE might bind to Keap1-Nrf2 complex to suppress NF-κB pathway. In vivo, QUE ameliorated the IDD process in the puncture-induced rat model. Together the present work suggests that QUE inhibits SASP factors expression and senescence phenotype in NPCs and ameliorates the progression of IDD via the Nrf2/NF-κB axis, which supports senolytic agent QUE as a potential therapeutic agent for the treatment of IDD.


|keywords=* Intervertebral disc degeneration
|keywords=* Heart failure
* NF-κB pathway
* comorbidities
* Nrf2
* geriatrics
* Quercetin
* metabolic bone disease
* Senescence
* osteoporosis
|full-text-url=https://sci-hub.do/10.1016/j.joca.2020.11.006
|full-text-url=https://sci-hub.do/10.1080/00015385.2020.1771885
}}
}}
==CCN3==
{{medline-entry
|title=Management of heart failure: an Italian national survey on fellows/specialists in geriatrics.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32383033


|mesh-terms=* Aged
* Geriatrics
* Heart Failure
* Humans
* Italy
* Specialization
* Stroke Volume
* Surveys and Questionnaires
|keywords=* Aged, 65 years or over
* Care survey
* Health
* Heart failure
|full-text-url=https://sci-hub.do/10.1007/s40520-020-01577-1
}}
{{medline-entry
{{medline-entry
|title=[[CCN3]] Signaling Is Differently Regulated in Placental Diseases Preeclampsia and Abnormally Invasive Placenta.
|title=Angiotensin-Converting Enzyme ([[ACE]]) genetic variation and longevity in Peruvian older people: a cross-sectional study.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/33304321
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32281429
|abstract=An adequate development of the placenta includes trophoblast differentiation with the processes of trophoblast migration, invasion, cellular senescence and apoptosis which are all crucial to establishing a successful pregnancy. Altered placental development and function lead to placental diseases such as preeclampsia (PE) which is mainly characterized by insufficient trophoblast invasion and abnormally invasive placenta (AIP) disorders ([i]Placenta accreta[/i], [i]increta[/i], or [i]percreta)[/i] which are characterized by excessive trophoblast invasion. Both of them will cause maternal and fetal morbidity/mortality. However, the etiology of these diseases is still unclear. Our previous study has shown that the matricellular protein [i]nephroblastoma overexpressed[/i] (NOV, [[CCN3]]) induces G0/G1 cell cycle arrest, drives trophoblast cells into senescence and activates FAK and Akt kinases resulting in reduced cell proliferation and enhanced migration capability of the human trophoblast cell line SGHPL-5. The present study focuses on whether [[CCN3]] can alter cell cycle-regulated pathways associated with trophoblast senescence and invasion activity in pathological versus gestational age-matched control placentas. Cell cycle regulator proteins were investigated by immunoblotting and qPCR. For localization of [[CCN3]], p16, p21, and Cyclin D1 proteins, co-immunohistochemistry was performed. In early-onset PE placentas, [[CCN3]] was expressed at a significantly lower level compared to gestational age-matched controls. The decrease of [[CCN3]] level is associated with an increase in p53, Cyclin E1 and pRb protein expression, whereas the level of cleaved Notch-1, p21, Cyclin D1, pFAK, pAKT, and pmTOR protein decreased. In term AIP placentas, the expression of [[CCN3]] was significantly increased compared to matched term controls. This increase was correlated to an increase in p53, p16, p21, Cyclin D1, cleaved Notch-1, pFAK, pAkt, and pmTOR whereas pRb was significantly decreased. However, in late PE and early AIP placentas, no significant differences in [[CCN3]], p16, p21, Cyclin D1, p53, and cleaved Notch-1 expression were found when matched to appropriate controls. [[CCN3]] expression levels are correlated to markers of cell cycle arrest oppositely in PE and AIP by activating the FAK/AKT pathway in AIP or down-regulating in PE. This may be one mechanism to explain the different pathological features of placental diseases, PE and AIP.
 
|mesh-terms=* Aged
* Aged, 80 and over
* Cross-Sectional Studies
* Female
* Genetic Variation
* Humans
* Longevity
* Male
* Middle Aged
* Peptidyl-Dipeptidase A
* Peru
* Polymorphism, Genetic
|keywords=* ACE gene
* Longevity
* Perú
* ageing
|full-text-url=https://sci-hub.do/10.1080/03014460.2020.1748227
}}
{{medline-entry
|title=COVID-19 and chronological aging: senolytics and other anti-aging drugs for the treatment or prevention of corona virus infection?
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32229706


|keywords=* CCN3
|mesh-terms=* Age Factors
* abnormally invasive placenta
* Aged
* invasion
* Aged, 80 and over
* preeclampsia
* Aging
* Angiotensin-Converting Enzyme 2
* Antiviral Agents
* Azithromycin
* Betacoronavirus
* COVID-19
* Coronavirus Infections
* Dipeptidyl Peptidase 4
* Humans
* Hydroxychloroquine
* Pandemics
* Peptidyl-Dipeptidase A
* Pneumonia, Viral
* Quercetin
* Receptors, Virus
* SARS-CoV-2
|keywords=* Azithromycin
* COVID-19
* Doxycycline
* Hydroxy-chloroquine
* Quercetin
* Rapamycin
* aging
* antibiotic
* corona virus
* drug repurposing
* prevention
* senescence
* senescence
* trophoblast
* senolytic drug therapy
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7701218
* viral replication
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7202514
}}
}}
==CCS==
{{medline-entry
|title=[i]A[/i]ngiotensin Converting Enzyme Inhibitors [i]C[/i]ombined with [i]E[/i]xercise for Hypertensive [i]S[/i]eniors (The [[ACE]]S Trial): Study Protocol of a Randomized Controlled Trial.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32039215


{{medline-entry
|title=Frailty Significantly Associated with a Risk for Mid-term Outcomes in Elderly Chronic Coronary Syndrome Patients: a Prospective Study.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/33306315
|abstract=Frailty is a condition of elderly characterized by increased vulnerability to stressful events. Frail patients are more likely to have adverse events. The purposes of this study were to define frailty in patients aged ≥ 70 years with chronic coronary syndrome ([[CCS]]) and to evaluate mortality and prognostic significance of frailty in these patients. We included 99 patients, ≥ 70 years old (mean age 74±5.3 years), with diagnosis of [[CCS]]. They were followed-up for up to 12 months. The frailty score was evaluated according to the Canadian Study of Health and Aging (CSHA). All patients were divided as frail or non-frail. The groups were compared for their characteristics and clinical outcomes. Fifty patients were classified as frail, and 49 patients as non-frail. The 12-month Major Adverse Cardiac Events (MACE) rate was 69.4% in frail patients and 20% in non-frail patients. Frailty increases the risk for MACE as much as 3.48 times. Two patients died in the non-frail group and 11 patients died in the frail group. Frailty increases the risk for death as much as 6.05 times. When we compared the aforementioned risk factors by multivariate analysis, higher CSHA frailty score was associated with increased MACE and death (relative risk [RR] = 22.94, 95% confidence interval [CI] 3.33-158.19, P=0.001, for MACE; RR = 7.41, 95% CI 1.44-38.03, P=0.016, for death). Being a frail elderly [[CCS]] patient is associated with worse outcomes. Therefore, frailty score should be evaluated for elderly [[CCS]] patients as a prognostic marker.


|keywords=* Aging
|keywords=* aging
* Canada
* antihypertensive
* Confidence Intervals
* exercise
* Death
* functional status
* Frail Elderly
* hypertension
* Frailty
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6988302
* Heart
* Multivariate Analysis
* Prognosis
* Risk Factors
|full-text-url=https://sci-hub.do/10.21470/1678-9741-2019-0484
}}
}}
==CD28==
{{medline-entry
{{medline-entry
|title=Premature CD4  T Cells Senescence Induced by Chronic Infection in Patients with Acute Coronary Syndrome.
|title=Vascular age.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/33269101
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32013519
|abstract=Acquired immune responses mediated by CD4  T cells contribute to the initiation and progression of acute coronary syndrome (ACS). ACS patients show acquired immune system abnormalities that resemble the characteristics of autoimmune dysfunction described in the elderly. This study aimed to investigate the role of premature CD4  T cells senescence in ACS and the underlying mechanism. We compared the immunological status of 25 ACS patients, 15 young healthy individuals (C1), and 20 elderly individuals with absence of ACS (C2). The percentages of CD4  T lymphocyte subsets (including naïve, regulatory, memory and effector T cells) in peripheral blood were analyzed. In ACS patients, a significant expansion of CD4 [[CD28]]  effector T cells and a decline of CD4 CD25 CD62L Treg cells were observed. In addition, patients with ACS showed an accelerated loss of CD4 CD45RA CD62L  naïve T cells and a compensatory increase in the number of CD4 CD45RO  memory T cells. ACS patients demonstrated no significant difference in frequency of T cell receptor excision circles (TRECs) compared to age-matched healthy volunteers. The expression of p16  was increased while CD62L was decreased in CD4 [[CD28]]  T cells of ACS patients. Compared to healthy donors, ACS patients demonstrated the lowest telomerase activity in both CD4 [[CD28]] and CD4 [[CD28]]  T cells. The serum levels of C-reactive protein, Cytomegalovirus IgG, [i]Helicobactor pylori[/i] IgG and [i]Chlamydia pneumonia[/i] IgG were significantly higher in ACS patients. The results suggested that the percentage of CD4  T cell subpopulations correlated with chronic infection, which contributes to immunosenescence. In conclusion, chronic infection induced senescence of premature CD4 T cells, which may be responsible for the development of ACS.
 
|mesh-terms=* Adolescent
* Adult
* Aged
* Aging
* Angiotensin-Converting Enzyme Inhibitors
* Atherosclerosis
* Child
* Elasticity
* Humans
* Middle Aged
* Perindopril
* Pulse Wave Analysis
* Vascular Stiffness
* Young Adult
|keywords=* ACE inhibitors
* CT angiography
* atorvastatin
* dyslipidemia
* hypertension
* intima media thickness (IMT)
* perindopril
* pulse wave velocity (PWV)
* statins
* vascular age


|keywords=* CD28null T cells
* CD4+ T cells
* acute coronary syndrome
* immunosenescence
* infection
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7673853
}}
}}
==CD34==
==ACE2==


{{medline-entry
{{medline-entry
|title=ACE2/ACE imbalance and impaired vasoreparative functions of stem/progenitor cells in aging.
|title=How Does SARS-CoV-2 Affect the Central Nervous System? A Working Hypothesis.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/33247425
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/33304284
|abstract=Aging increases risk for ischemic vascular diseases. Bone marrow-derived hematopoietic stem/progenitor cells (HSPCs) are known to stimulate vascular regeneration. Activation of either the Mas receptor (MasR) by angiotensin-(1-7) (Ang-(1-7)) or angiotensin-converting enzyme-2 (ACE2) stimulates vasoreparative functions in HSPCs. This study tested if aging is associated with decreased ACE2 expression in HSPCs and if Ang-(1-7) restores vasoreparative functions. Flow cytometric enumeration of Lin CD45 [[CD34]]  cells was carried out in peripheral blood of male or female individuals (22-83 years of age). Activity of ACE2 or the classical angiotensin-converting enzyme (ACE) was determined in lysates of HSPCs. Lin Sca-1 cKit  (LSK) cells were isolated from young (3-5 months) or old (20-22 months) mice, and migration and proliferation were evaluated. Old mice were treated with Ang-(1-7), and mobilization of HSPCs was determined following ischemia induced by femoral ligation. A laser Doppler blood flow meter was used to determine blood flow. Aging was associated with decreased number (Spearman r = - 0.598, P < 0.0001, n = 56), decreased ACE2 (r = - 0.677, P < 0.0004), and increased ACE activity (r = 0.872, P < 0.0001) (n = 23) in HSPCs. Migration or proliferation of LSK cells in basal or in response to stromal-derived factor-1α in old cells is attenuated compared to young, and these dysfunctions were reversed by Ang-(1-7). Ischemia increased the number of circulating LSK cells in young mice, and blood flow to ischemic areas was recovered. These responses were impaired in old mice but were restored by treatment with Ang-(1-7). These results suggest that activation of ACE2 or MasR would be a promising approach for enhancing ischemic vascular repair in aging.
 


|keywords=* ACE2
|keywords=* ACE2
* Aging
* Alzheimer disease
* Angiotensin-(1-7)
* Ang(1-7)/Mas
* Hematopoietic stem/progenitor cells
* COVID-19
* Ischemia
* RAAS
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7694587
* SARS-CoV
* brain aging
* neurodegenerative and psychiatric disorders abstract
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7701095
}}
}}
{{medline-entry
{{medline-entry
|title=Comparing the Effect of TGF-β Receptor Inhibition on Human Perivascular Mesenchymal Stromal Cells Derived from Endometrium, Bone Marrow and Adipose Tissues.
|title=Bioinformatic characterization of angiotensin-converting enzyme 2, the entry receptor for SARS-CoV-2.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/33271899
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/33112891
|abstract=Rare perivascular mesenchymal stromal cells (MSCs) with therapeutic properties have been identified in many tissues. Their rarity necessitates extensive in vitro expansion, resulting in spontaneous differentiation, cellular senescence and apoptosis, producing therapeutic products with variable quality and decreased potency. We previously demonstrated that A83-01, a transforming growth factor beta (TGF-β) receptor inhibitor, maintained clonogenicity and promoted the potency of culture-expanded premenopausal endometrial MSCs using functional assays and whole-transcriptome sequencing. Here, we compared the effects of A83-01 on MSCs derived from postmenopausal endometrium, menstrual blood, placenta decidua-basalis, bone marrow and adipose tissue. Sushi-domain-containing-2 (SUSD2 ) and [[CD34]] CD31 CD45  MSCs were isolated. Expanded MSCs were cultured with or without A83-01 for 7 days and assessed for MSC properties. SUSD2 identified perivascular cells in the placental decidua-basalis, and their maternal origin was validated. A83-01 promoted MSC proliferation from all sources except bone marrow and only increased SUSD2 expression and prevented apoptosis in MSCs from endometrial-derived tissues. A83-01 only improved the cloning efficiency of postmenopausal endometrial MSCs (eMSCs), and expanded adipose tissue MSCs (adMSCs) underwent significant senescence, which was mitigated by A83-01. MSCs derived from bone marrow (bmMSCs) were highly apoptotic, but A83-01 was without effect. A83-01 maintained the function and phenotype in MSCs cultured from endometrial, but not other, tissues. Our results also demonstrated that cellular SUSD2 expression directly correlates with the functional phenotype.
 
|mesh-terms=* Aging
* Angiotensin-Converting Enzyme 2
* Betacoronavirus
* Binding Sites
* COVID-19
* Carrier Proteins
* Computational Biology
* Coronavirus Infections
* Female
* Gene Expression Regulation, Enzymologic
* Gene Ontology
* Humans
* Interferons
* Lung
* Male
* Metalloproteases
* Neovascularization, Physiologic
* Organ Specificity
* Pandemics
* Peptidyl-Dipeptidase A
* Pneumonia, Viral
* Promoter Regions, Genetic
* RNA, Messenger
* Receptors, Virus
* Renin-Angiotensin System
* SARS-CoV-2
* Sex Characteristics
* Single-Cell Analysis
* Transcription Factors
* Transcription Initiation Site
* Virus Attachment


|keywords=* SUSD2
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7592753
* adipose tissue
* apoptosis
* bone marrow
* clonogenicity
* endometrium
* menstrual fluid
* perivascular mesenchymal stromal cells
* placenta
* senescence
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7712261
}}
}}
==CD4==
{{medline-entry
|title=A mouse-adapted model of SARS-CoV-2 to test COVID-19 countermeasures.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32854108


{{medline-entry
|mesh-terms=* Aging
|title=IL-1β-MyD88-mTOR Axis Promotes Immune-Protective IL-17A Foxp3  Cells During Mucosal Infection and Is Dysregulated With Aging.
* Angiotensin-Converting Enzyme 2
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/33240286
* Animals
|abstract=[[CD4]] Foxp3 T  maintain immune homeostasis, but distinct mechanisms underlying their functional heterogeneity during infections are driven by specific cytokine milieu. Here we show that MyD88 deletion in Foxp3  cells altered their function and resulted in increased fungal burden and immunopathology during oral [i]Candida albicans[/i] (CA) challenge. Excessive inflammation due to the absence of MyD88 in T  coincided with a reduction of the unique population of IL-17A expressing Foxp3  cells (T 17) and an increase in dysfunctional IFN-γ /Foxp3  cells (T IFN-γ) in infected mice. Failure of MyD88  T  to regulate effector [[CD4]]  T cell functions correlated with heightened levels of IFN-γ in [[CD4]]  T cells, as well as increased infiltration of inflammatory monocytes and neutrophils in oral mucosa [i]in vivo[/i]. Mechanistically, IL-1β/MyD88 signaling was required for the activation of IRAK-4, Akt, and mTOR, which led to the induction and proliferation of T 17 cells. In the absence of IL-1 receptor signaling, T 17 cells were reduced, but IL-6-driven expansion of T IFN-γ cells was increased. This mechanism was physiologically relevant during [i]Candida[/i] infection in aged mice, as they exhibited IL-1 receptor/MyD88 defect in Foxp3  cells, loss of p-mTOR T 17 cells and reduced levels of IL-1β in oral mucosa, which coincided with persistent tongue inflammation. Concurrent with T  dysfunction, aging was associated with increased [[CD4]]  T cell hyperactivation and heightened levels of IL-6 in mice and humans in oral mucosa [i]in vivo[/i]. Taken together, our data identify IL-1β/MyD88/T  axis as a new component that modulates inflammatory responses in oral mucosa. Also, dysregulation of this axis in an aging immune system may skew host defense towards an immunopathological response in mucosal compartments.
* Betacoronavirus
* COVID-19
* COVID-19 Vaccines
* Coronavirus Infections
* Disease Models, Animal
* Female
* Forkhead Transcription Factors
* Humans
* Interferon-alpha
* Interferons
* Interleukins
* Male
* Mice
* Mice, Inbred BALB C
* Mice, Transgenic
* Models, Molecular
* Pandemics
* Peptidyl-Dipeptidase A
* Pneumonia, Viral
* Receptors, Virus
* SARS-CoV-2
* Viral Vaccines


|keywords=* Candida
|full-text-url=https://sci-hub.do/10.1038/s41586-020-2708-8
* Foxp3
* IL-1β
* Treg
* Treg17
* aging
* fungal infection
* senescence
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7677307
}}
}}
{{medline-entry
{{medline-entry
|title=Thymus involution sets the clock of declined immunity and repair with aging.
|title=COVID-19 and Senotherapeutics: Any Role for the Naturally-occurring Dipeptide Carnosine?
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/33248315
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32765939
|abstract=Aging is generally characterized as a gradual increase in tissue damage, which is associated with senescence and chronic systemic inflammation and is evident in a variety of age-related diseases. The extent to which such tissue damage is a result of a gradual decline in immune regulation, which consequently compromises the capacity of the body to repair damages, has not been fully explored. Whereas [[CD4]] T lymphocytes play a critical role in the orchestration of immunity, thymus involution initiates gradual changes in the [[CD4]] T-cell landscape, which may significantly compromise tissue repair. In this review, we describe the lifespan accumulation of specific dysregulated [[CD4]] T-cell subsets and their coevolution with systemic inflammation in the process of declined immunity and tissue repair capacity with age. Then, we discuss the process of thymus involution-which appears to be most pronounced around puberty-as a possible driver of the aging T-cell landscape. Finally, we identify individualized T cell-based early diagnostic biomarkers and therapeutic strategies for age-related diseases.
 


|keywords=* Aging
|keywords=* acetyl-carnosine
* Chronic systemic inflammation
* aging
* Dysregulated CD4 T cells
* carnosine
* Immune-mediated repair
* inflammation
* Thymus
* lungs
|full-text-url=https://sci-hub.do/10.1016/j.arr.2020.101231
* olfaction
* virus
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7390525
}}
}}
{{medline-entry
{{medline-entry
|title=Food insecurity and T-cell dysregulation in women living with HIV on antiretroviral therapy.
|title=The dual impact of [[ACE2]] in COVID-19 and ironical actions in geriatrics and pediatrics with possible therapeutic solutions.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/33247896
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32653522
|abstract=Food insecurity is associated with increased morbidity and mortality in people living with HIV on antiretroviral therapy, but its relationship with immune dysregulation, a hallmark of HIV infection and comorbidity, is unknown. In 241 women participating in the Women's Interagency HIV Study, peripheral blood mononuclear cells were characterized by flow cytometry to identify cell subsets, comprising surface markers of activation (%CD38+HLADR+), senescence (%CD57+CD28-), exhaustion (%PD-1+), and co-stimulation (%CD57- CD28+) on [[CD4]]+ and CD8+ T-cells. Mixed-effects linear regression models were used to assess the relationships of food insecurity with immune outcomes, accounting for repeated measures at up to three study visits and adjusting for sociodemographic and clinical factors. At the baseline study visit, 71% of participants identified as non-Hispanic Black, 75% were virally suppressed, and 43% experienced food insecurity. Food insecurity was associated with increased activation of [[CD4]]+ and CD8+ T-cells, increased senescence of CD8+ T-cells, and decreased co-stimulation of [[CD4]]+ and CD8+ T-cells (all p<0.05), adjusting for age, race/ethnicity, income, education, substance use, smoking, HIV viral load, and [[CD4]] cell count. In stratified analyses, the association of food insecurity with [[CD4]]+ T-cell activation was more pronounced in women with uncontrolled HIV (viral load >40 copies/mL and [[CD4]] <500 cells/mm 3), but remained statistically significant in those with controlled HIV. Food insecurity may contribute to the persistent immune activation and senescence in women living with HIV on antiretroviral therapy, independently of HIV control. Reducing food insecurity may be important for decreasing non-AIDS-related disease risk in this population.


|keywords=* HIV
|mesh-terms=* Age Factors
* exhaustion
* Aged
* food insecurity
* Aged, 80 and over
* immune activation
* Angiotensin-Converting Enzyme 2
* senescence
* Anti-Inflammatory Agents
|full-text-url=https://sci-hub.do/10.1093/cid/ciaa1771
* Betacoronavirus
* COVID-19
* Child
* Child, Preschool
* Coronavirus
* Coronavirus Infections
* Female
* Geriatrics
* Humans
* Infant
* Infant, Newborn
* Male
* Pandemics
* Pediatrics
* Peptidyl-Dipeptidase A
* Pneumonia, Viral
* Protein Binding
* Receptors, Virus
* Renin-Angiotensin System
* SARS-CoV-2
* Severe Acute Respiratory Syndrome
* Virus Internalization
|keywords=* ACE2
* Angiotensin 2
* Angiotensin-(1–7)
* Corona virus
* Glycoprotein spikes
* RAAS system
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7347488
}}
}}
{{medline-entry
{{medline-entry
|title=Rapamycin Eyedrops Increased [[CD4]] Foxp3  Cells and Prevented Goblet Cell Loss in the Aged Ocular Surface.
|title=The possible pathophysiology mechanism of cytokine storm in elderly adults with COVID-19 infection: the contribution of "inflame-aging".
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/33255287
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32529477
|abstract=Dry eye disease (DED), one of the most prevalent conditions among the elderly, is a chronic inflammatory disorder that disrupts tear film stability and causes ocular surface damage. Aged C57BL/6J mice spontaneously develop DED. Rapamycin is a potent immunosuppressant that prolongs the lifespan of several species. Here, we compared the effects of daily instillation of eyedrops containing rapamycin or empty micelles for three months on the aged mice. Tear cytokine/chemokine profile showed a pronounced increase in vascular endothelial cell growth factor-A (VEGF-A) and a trend towards decreased concentration of Interferon gamma (IFN)-γ in rapamycin-treated groups. A significant decrease in inflammatory markers in the lacrimal gland was also evident ([i]IFN-γ[/i], [i]IL-12[/i], [i]CIITA[/i] and [i]Ctss[/i]); this was accompanied by slightly diminished [i]Unc-51 Like Autophagy Activating Kinase 1[/i] ([i]ULK1[/i]) transcripts. In the lacrimal gland and draining lymph nodes, we also observed a significant increase in the [[CD4]]5 [[CD4]] Foxp3  cells in the rapamycin-treated mice. More importantly, rapamycin eyedrops increased conjunctival goblet cell density and area compared to the empty micelles. Taken together, evidence from these studies indicates that topical rapamycin has therapeutic efficacy for age-associated ocular surface inflammation and goblet cell loss and opens the venue for new investigations on its role in the aging process of the eye.


|keywords=* aging
|mesh-terms=* Adipocytes
* dry eye
* Age Factors
* goblet cell
* Aged
* inflammation
* Aging
* lacrimal gland
* Angiotensin II Type 2 Receptor Blockers
* ocular surface
* Autophagy
* rapamycin
* Betacoronavirus
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7727717
* COVID-19
* Cellular Senescence
* Coronavirus Infections
* Cytokine Release Syndrome
* Cytokines
* Humans
* Immune System
* Inflammation
* Pandemics
* Pneumonia, Viral
* Reactive Oxygen Species
* Receptor, Angiotensin, Type 2
* SARS-CoV-2
* Vitamin D
* Vitamin D Deficiency
|keywords=* ACE2 receptor
* Autophagy
* COVID-19
* Cytokine storm
* Senescent cell
* Vitamin D
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7289226
}}
}}
{{medline-entry
{{medline-entry
|title=Antioxidants N-Acetylcysteine and Vitamin C Improve T Cell Commitment to Memory and Long-Term Maintenance of Immunological Memory in Old Mice.
|title=Decoding SARS-CoV-2 hijacking of host mitochondria in COVID-19 pathogenesis.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/33228213
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32510973
|abstract=Aging is characterized by reduced immune responses, a process known as immunosenescence. Shortly after their generation, antigen-experienced adaptive immune cells, such as CD8  and [[CD4]]  T cells, migrate into the bone marrow (BM), in which they can be maintained for long periods of time within survival niches. Interestingly, we recently observed how oxidative stress may negatively support the maintenance of immunological memory in the BM in old age. To assess whether the generation and maintenance of immunological memory could be improved by scavenging oxygen radicals, we vaccinated 18-months (old) and 3-weeks (young) mice with alum-OVA, in the presence/absence of antioxidants vitamin C (Vc) and/or N-acetylcysteine (NAC). To monitor the phenotype of the immune cell population, blood was withdrawn at several time-points, and BM and spleen were harvested 91 days after the first alum-OVA dose. Only in old mice, memory T cell commitment was boosted with some antioxidant treatments. In addition, oxidative stress and the expression of pro-inflammatory molecules decreased in old mice. Finally, changes in the phenotype of dendritic cells, important regulators of T cell activation, were additionally observed. Taken together, our data show that the generation and maintenance of memory T cells in old age may be improved by targeting oxidative stress.


|keywords=* NAC
|mesh-terms=* Adaptive Immunity
* T cells
* Angiotensin-Converting Enzyme 2
* Animals
* Betacoronavirus
* COVID-19
* Coronavirus Infections
* DNA, Mitochondrial
* Gene Expression Regulation, Viral
* Host Microbial Interactions
* Humans
* Immunity, Innate
* Mitochondria
* Pandemics
* Peptidyl-Dipeptidase A
* Pneumonia, Viral
* RNA, Viral
* SARS-CoV-2
* Virus Replication
|keywords=* COVID-19
* SARS-CoV
* aging
* aging
* antioxidants
* coronavirus
* immunosenescence
* mitochondria
* vaccination
* mitochondrial DNA
* vitamin C
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7381712
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7699597
}}
}}
{{medline-entry
{{medline-entry
|title=Distinct Age-Related Epigenetic Signatures in [[CD4]] and CD8 T Cells.
|title=A Mouse Model of SARS-CoV-2 Infection and Pathogenesis.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/33262764
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32485164
|abstract=Healthy immune aging is in part determined by how well the sizes of naïve T cell compartments are being maintained with advancing age. Throughout adult life, replenishment largely derives from homeostatic proliferation of existing naïve and memory T cell populations. However, while the subpopulation composition of [[CD4]] T cells is relatively stable, the CD8 T cell compartment undergoes more drastic changes with loss of naïve CD8 T cells and accumulation of effector T cells, suggesting that [[CD4]] T cells are more resilient to resist age-associated changes. To determine the epigenetic basis for these differences in behaviors, we compared chromatin accessibility maps of [[CD4]] and CD8 T cell subsets from young and old individuals and related the results to the expressed transcriptome. The dominant age-associated signatures resembled hallmarks of differentiation, which were more pronounced for CD8 naïve and memory than the corresponding [[CD4]] T cell subsets, indicating that CD8 T cells are less able to keep cellular quiescence upon homeostatic proliferation. In parallel, CD8 T cells from old adults, irrespective of their differentiation state, displayed greater reduced accessibility to genes of basic cell biological function, including genes encoding ribosomal proteins. One possible mechanism is the reduced expression of the transcription factors YY1 and NRF1. Our data suggest that chromatin accessibility signatures can be identified that distinguish [[CD4]] and CD8 T cells from old adults and that may confer the higher resilience of [[CD4]] T cells to aging.


|keywords=* T-cell
|mesh-terms=* Aging
* T-cell homeostasis
* Angiotensin-Converting Enzyme 2
* aging
* Animals
* chromatin accessibility
* Betacoronavirus
* epigenetics
* Brain
* ribosomal proteins
* COVID-19
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7686576
* CRISPR-Cas Systems
* Coronavirus Infections
* Cytokines
* Disease Models, Animal
* Gene Knock-In Techniques
* Lung
* Lung Diseases, Interstitial
* Mice, Inbred C57BL
* Nose
* Pandemics
* Peptidyl-Dipeptidase A
* Pneumonia, Viral
* RNA, Viral
* SARS-CoV-2
* Stomach
* Trachea
* Viral Load
* Virus Replication
|keywords=* SARS-CoV-2
* angiotensin-converting enzyme II
* hACE2-KI/NIFDC
* mouse model
* pathogenesis
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7250783
}}
}}
{{medline-entry
{{medline-entry
|title=Identification of Key Genes and Potential New Biomarkers for Ovarian Aging: A Study Based on RNA-Sequencing Data.
|title=COVID-19-associated cardiovascular morbidity in older adults: a position paper from the Italian Society of Cardiovascular Researches.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/33304387
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32430627
|abstract=Ovarian aging leads to reproductive and endocrine dysfunction, causing the disorder of multiple organs in the body and even declined quality of offspring's health. However, few studies have investigated the changes in gene expression profile in the ovarian aging process. Here, we applied integrated bioinformatics to screen, identify, and validate the critical pathogenic genes involved in ovarian aging and uncover potential molecular mechanisms. The expression profiles of GSE84078 were downloaded from the Gene Expression Omnibus (GEO) database, which included the data from ovarian samples of 10 normal C57BL/6 mice, including old (21-22 months old, ovarian failure period) and young (5-6 months old, reproductive bloom period) ovaries. First, we filtered 931 differentially expressed genes (DEGs), including 876 upregulated and 55 downregulated genes through comparison between ovarian expression data from old and young mice. Functional enrichment analysis showed that biological functions of DEGs were primarily immune response regulation, cell-cell adhesion, and phagosome pathway. The most closely related genes among DEGs ([i]Tyrobp[/i], [i]Rac2[/i], [i]Cd14[/i], [i]Zap70[/i], [i]Lcp2[/i], [i]Itgb2[/i], [i]H2-Ab1[/i], and [i]Fcer1g[/i]) were identified by constructing a protein-protein interaction (PPI) network and consequently verified using mRNA and protein quantitative detection. Finally, the immune cell infiltration in the ovarian aging process was also evaluated by applying CIBERSORT, and a correlation analysis between hub genes and immune cell type was also performed. The results suggested that plasma cells and naïve [[CD4]]  T cells may participate in ovarian aging. The hub genes were positively correlated with memory B cells, plasma cells, M1 macrophages, Th17 cells, and immature dendritic cells. In conclusion, this study indicates that screening for DEGs and pathways in ovarian aging using bioinformatic analysis could provide potential clues for researchers to unveil the molecular mechanism underlying ovarian aging. These results could be of clinical significance and provide effective molecular targets for the treatment of ovarian aging.


|keywords=* GEO database
|mesh-terms=* Age Factors
* bioinformatics
* Aged
* biomarker
* Betacoronavirus
* immune cell infiltration
* COVID-19
* ovarian aging
* Cardiovascular Diseases
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7701310
* Coronavirus Infections
* Female
* Humans
* Italy
* Male
* Middle Aged
* Pandemics
* Pneumonia, Viral
* Risk Factors
* SARS-CoV-2
|keywords=* Acute myocardial injury
* Aging
* COVID-19
* Cardiovascular system
* Frailty
* SARS-CoV-2
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7237344
}}
}}
==CPNE1==
{{medline-entry
|title=Gut microbiota and Covid-19- possible link and implications.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32430279


|mesh-terms=* Aging
* Betacoronavirus
* COVID-19
* Coronavirus Infections
* Diet
* Dysbiosis
* Gastrointestinal Microbiome
* Gastrointestinal Tract
* Homeostasis
* Humans
* Immunity
* Lung
* Pandemics
* Pneumonia, Viral
* SARS-CoV-2
|keywords=* Covid-19
* Diet
* Dysbiosis
* Gut microbiome
* Immunity
* Lung microbiota
* SARS-CoV-2
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7217790
}}
{{medline-entry
{{medline-entry
|title=Prevalent intron retention fine-tunes gene expression and contributes to cellular senescence.
|title=Inflamm-aging: Why older men are the most susceptible to SARS-CoV-2 complicated outcomes.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/33274830
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32389499
|abstract=Intron retention (IR) is the least well-understood alternative splicing type in animals, and its prevalence and function in physiological and pathological processes have long been underestimated. Cellular senescence contributes to individual aging and age-related diseases and can also serve as an important cancer prevention mechanism. Dynamic IR events have been observed in senescence models and aged tissues; however, whether and how IR impacts senescence remain unclear. Through analyzing polyA  RNA-seq data from human replicative senescence models, we found IR was prevalent and dynamically regulated during senescence and IR changes negatively correlated with expression alteration of corresponding genes. We discovered that knocking down (KD) splicing factor U2AF1, which showed higher binding density to retained introns and decreased expression during senescence, led to senescence-associated phenotypes and global IR changes. Intriguingly, U2AF1-KD-induced IR changes also negatively correlated with gene expression. Furthermore, we demonstrated that U2AF1-mediated IR of specific gene ([[CPNE1]] as an example) contributed to cellular senescence. Decreased expression of U2AF1, higher IR of [[CPNE1]], and reduced expression of [[CPNE1]] were also discovered in dermal fibroblasts with age. We discovered prevalent IR could fine-tune gene expression and contribute to senescence-associated phenotypes, largely extending the biological significance of IR.


|keywords=* CPNE1
|mesh-terms=* Aged
* U2AF1
* Aged, 80 and over
* intron retention
* Aging
* senescence
* Angiotensin-Converting Enzyme 2
* splicing factor
* Antibodies, Monoclonal, Humanized
|full-text-url=https://sci-hub.do/10.1111/acel.13276
* Betacoronavirus
* COVID-19
* Comorbidity
* Coronavirus Infections
* Female
* Humans
* Inflammation
* Interferon Type I
* Interleukin-6
* Male
* Pandemics
* Peptidyl-Dipeptidase A
* Pneumonia, Viral
* SARS-CoV-2
* Severe Acute Respiratory Syndrome
|keywords=* COVID-19
* Cardiovascular diseases
* Host-directed therapies
* Inflamm-aging
* SARS-CoV-2
* interleukin-6
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7252014
}}
}}
==CRP==
{{medline-entry
|title=Restoration of the Renin-Angiotensin System Balance Is a Part of the Effect of Fasting on Cardiovascular Rejuvenation: Role of Age and Fasting Models.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31571520


{{medline-entry
|title=Omega-3 supplementation improves isometric strength but not muscle anabolic and catabolic signaling in response to resistance exercise in healthy older adults.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/33284965
|abstract=Old skeletal muscle exhibits decreased anabolic sensitivity, eventually contributing to muscle wasting. Besides anabolism, also muscle inflammation and catabolism are critical players in regulating the old skeletal muscle's sensitivity. Omega-3 fatty acids (ω-3) are an interesting candidate to reverse anabolic insensitivity via anabolic actions. Yet, it remains unknown whether ω-3 also attenuates muscle inflammation and catabolism. The present study investigates the effect of ω-3 supplementation on muscle inflammation and metabolism (anabolism/catabolism) upon resistance exercise (RE). Twenty-three older adults (OA) (65-84yr;8♀) were randomized to receive ω-3 (~3g·d -1) or corn oil (PLAC) and engaged in a 12-wk RE program (3x·wk -1). Before and after intervention, muscle volume, strength and systemic inflammation were assessed, and muscle biopsies were analysed for markers of anabolism, catabolism and inflammation. Isometric knee-extensor strength increased in ω-3 (+12.2%), but not in PLAC (-1.4%; pinteraction=0.015), whereas leg press strength improved in both conditions (+27.1%; ptime<0.001). RE, but not ω-3, decreased inflammatory (p65NF-κB) and catabolic (FOXO1, LC3b) markers, and improved muscle quality. Yet, muscle volume remained unaffected by RE and ω-3. Accordingly, muscle anabolism (mTORC1) and plasma [[CRP]] remained unchanged by RE and ω-3, whereas serum IL-6 tended to decrease in ω-3 (pinteraction=0.07). These results show that, despite no changes in muscle volume, RE-induced gains in isometric strength can be further enhanced by ω-3. However, ω-3 did not improve RE-induced beneficial catabolic or inflammatory adaptations. Irrespective of muscle volume, gains in strength (primary criterion for sarcopenia) might be explained by changes in muscle quality due to muscle inflammatory or catabolic signaling.


|keywords=* Muscle wasting
|keywords=* aging
* aging
* cardiac hypertrophy index
* anabolic resistance
* intermittent fasting
* inflammation
* renin–angiotensin system (RAS)
* resistance training
|full-text-url=https://sci-hub.do/10.1089/rej.2019.2254
* sarcopenia
|full-text-url=https://sci-hub.do/10.1093/gerona/glaa309
}}
}}
==CTSA==
{{medline-entry
{{medline-entry
|title=A [[CTSA]]-based consultation service to advance research on special and underserved populations.
|title=Angiotensin 1-7 alleviates aging-associated muscle weakness and bone loss, but is not associated with accelerated aging in [[ACE2]]-knockout mice.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/33244406
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31519791
|abstract=In this report, we describe the implementation and short-term outcomes of a Special Populations Consultation Service within the University of California, Los Angeles (UCLA) Clinical and Translational Science Institute (CTSI). With the goal of increasing the quality and quantity of special population (SP) research, the UCLA CTSI Integrating Special Populations program designed a consultation service to support faculty and trainees conducting research involving one of three CTSI "special populations:" children, older adults, and/or minority; underserved; or health disparity populations. The Special Populations Consultation Service offers three types of activities: grant proposal studios, career consultations, and project reviews. UCLA CTSI faculty with appropriate content expertise serve as consultants. We evaluated this consultation model using satisfaction surveys and by quantifying funded grants and reported changes in career goals in SP research. Between 2016 and 2019, the Special Populations Consultation Service provided 59 consultations including 42 grant studios and was used by researchers at all levels from all four UCLA CTSI institutions. Recipients rated the consultations very highly. Funding success rates were 57% following K-level grant studios and 28% following R-level grant studios. Users of project and career consultations commonly attributed career accomplishments in part to their consultation experiences. The SP Consultation Service is feasible and acceptable and appears to enhance careers of investigators studying special populations.


|keywords=* faculty development
|mesh-terms=* Adipose Tissue
* geriatrics
* Aging
* grant review
* Angiotensin I
* grant studio
* Angiotensin-Converting Enzyme 2
* pediatrics
* Animals
* peer review
* Body Weight
* research consultation service
* Bone Resorption
* special populations
* Cyclin-Dependent Kinase Inhibitor p16
* underrepresented minorities
* Forelimb
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7681147
* Gene Deletion
* Hand Strength
* Male
* Mice, Inbred C57BL
* Mice, Knockout
* Muscle Weakness
* Muscles
* Organ Size
* PAX3 Transcription Factor
* Peptide Fragments
* Peptidyl-Dipeptidase A
* Proto-Oncogene Proteins
* Receptors, G-Protein-Coupled
* Renin-Angiotensin System
* Time Factors
|keywords=* Angiotensin 1-7
* Angiotensin Converting Enzyme 2
* Mas receptor
* Muscle weakness
* osteoporosis
|full-text-url=https://sci-hub.do/10.1042/CS20190573
}}
}}
==CXCL14==
==ACLY==


{{medline-entry
{{medline-entry
|title=Identification of genes associated with endometrial cell aging.
|title=In S. cerevisiae hydroxycitric acid antagonizes chronological aging and apoptosis regardless of citrate lyase.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/33258951
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32666259
|abstract=Aging of the uterine endometrium is a critical factor that affects reproductive success, but the mechanisms associated with uterine aging are unclear. In this study, we conducted a qualitative examination of age-related changes in endometrial tissues and identified candidate genes as markers for uterine aging. Gene expression patterns were assessed by two RNA sequencing experiments using uterine tissues from wild type (WT) C57BL/6 mice. Gene expression data obtained by RNA-sequencing were validated by real-time PCR. Genes expressing the pro-inflammatory cytokines Il17rb and chemokines Cxcl12 and Cxcl14 showed differential expression between aged WT mice and a group of mice composed of 5 and 8 week-old WT (young) animals. Protein expression levels of the above-mentioned genes and of IL8, which functions downstream of IL17RB, were analysed by quantitative immunohistochemistry of unaffected human endometrium tissue samples from patients in their 20 s and 40 s (10 cases each). In the secretory phase samples, 3,3'- diaminobenzidine (DAB) staining intensities of IL17RB, CXCL12 and [[CXCL14]] for patients in their 40 s were significantly higher than that for patients in their 20 s, as detected by a Mann Whitney U test. These results suggest that these genes are candidate markers for endometrial aging and for prediction of age-related infertility, although confirmation of these findings is needed in larger studies involving fertile and infertile women.
 


|keywords=* CXCL12
|keywords=* Aging
* CXCL14
* Apoptosis/necrosis
* IL17RB
* Caloric restriction mimetics
* endometrial cell aging
* Hydroxycitric acid
* infertility
* Oxidative stress
* quantitative
* Sch9 and Ras2 pathways
immunohistochemistry
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7527365
|full-text-url=https://sci-hub.do/10.1093/molehr/gaaa078
}}
}}
==DCN==
==ACR==


{{medline-entry
{{medline-entry
|title=Decorin inhibits the insulin-like growth factor I signaling in bone marrow mesenchymal stem cells of aged humans.
|title=Progenitor cell niche senescence reflects pathology of the parotid salivary gland in primary Sjögren's syndrome.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/33257596
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32159757
|abstract=Aging impairs the IGF-I signaling of bone marrow mesenchymal stem cells (bmMSCs), but the mechanism is unclear. Here, we found that the ability to auto-phosphorylate IGF-I receptor (IGF-IR) in response to IGF-I was decreased in the bmMSCs of aged donors. Conversely, data showed that decorin ([[DCN]]) expression was prominently increased in aged bmMSCs, and that under IGF-I treatment, [[DCN]] knockdown in serum-starved aged bmMSCs potentiated their mitogenic activity and IGF-IR auto-phosphorylation, whereas [[DCN]] overexpression in serum-starved adult bmMSCs decreased both activities. Co-immunoprecipitation assays suggested that IGF-I and [[DCN]] bound to IGF-IR in a competitive manner. Online MethPrimer predicted 4 CpG islands (CGIs) in the introns of [i][[DCN]][/i] gene. RT-qPCR and bisulfite sequencing showed that dimethyloxalylglycine, an inhibitor of DNA demethylation, increased [i][[DCN]][/i] mRNA expression and CGI-I methylation in adult bmMSCs, whereas 5-aza-2'-deoxycytidine, a DNA methylation inhibitor, decreased [i][[DCN]][/i] mRNA expression and CGI-I methylation in aged bmMSCs, and ultimately enhanced the proliferation of serum-starved aged bmMSCs under IGF-I stimulation. Thus, IGF-IR could be the prime target of aging in down-regulating the IGF-I signaling of bmMSCs, where [[DCN]] could be a critical mediator.
 


|keywords=* IGF-I
|keywords=* p16
* aging
* primary Sjögren’s syndrome
* bone marrow mesenchymal stem cell
* salivary gland
* osteoporosis
* salivary gland progenitor cells
* small leucine-rich proteoglycan
* senescence
|full-text-url=https://sci-hub.do/10.18632/aging.202166
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7516109
}}
}}
==EDF1==
{{medline-entry
|title=Jumping Joints: The Complex Relationship Between Osteoarthritis and Jumping Mechanography.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31655874


{{medline-entry
|title=Silencing of FOREVER YOUNG FLOWER Like Genes from Phalaenopsis Orchids Promotes Flower Senescence and Abscission.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/33237274
|abstract=Ectopic expression of FOREVER YOUNG FLOWER (FYF) delays floral senescence and abscission in transgenic Arabidopsis. To analyze the FYF function in Phalaenopsis orchids, two FYF-like genes (PaFYF1/2) were identified. PaFYF1/2 were highly expressed in young Phalaenopsis flowers, and their expression decreased significantly afterward until flower senescence. This pattern was strongly correlated with the process of flower senescence and revealed that PaFYF1/2 function to suppress senescence/abscission during early flower development. Interestingly, in flowers, PaFYF1 was consistently expressed less in petals than in lips/sepals, whereas PaFYF2 was expressed relatively evenly in all flower organs. This difference suggests a regulatory modification of the functions of PaFYF1 and PaFYF2 during Phalaenopsis flower evolution. Delayed flower senescence and abscission, which were unaffected by ethylene treatment, were observed in 35S::PaFYF1/2 and 35S::PaFYF1/2+SRDX transgenic Arabidopsis plants due to downregulation of the ethylene signaling and abscission-associated genes [[EDF1]]-4, IDA and BOP1/2. These results suggest a possible repressor role for Phalaenopsis PaFYF1/2 in controlling floral senescence/abscission by suppressing ethylene signaling and abscission-associated genes. To further validate the function of PaFYF1/2, PaFYF1/2-VIGS (virus-induced gene silencing) Phalaenopsis were generated and analyzed. Promotion of senescence and abscission was observed in PaFYF1/2-VIGS Phalaenopsis flowers by the upregulation of Pe[[EDF1]]/2, PeSAG39 and PeBOP1/2 expression, early occurrence of greening according to their increased chlorophyll content and reduction of water content in flower organs. Our results support that PaFYF1/2 function as transcriptional repressors to prohibit flower senescence and abscission in Phalaenopsis.


|keywords=*  
|keywords=* Aging
          FOREVER YOUNG FLOWER
* Jumping mechanography
       
* Muscle
*
* Osteoarthritis
          Phalaenopsis orchids
* Sarcopenia
* Abscission
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6994439
* Ethylene responses
* MADS-box gene
* Senescence
|full-text-url=https://sci-hub.do/10.1093/pcp/pcaa145
}}
}}
==EGF==
==ACVR1==


{{medline-entry
{{medline-entry
|title=Acute, exercise-induced alterations in cytokines and chemokines in the blood distinguish physically active and sedentary aging.
|title=Fibrodysplasia Ossificans Progressiva (FOP): A Segmental Progeroid Syndrome.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/33289019
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31998237
|abstract=Aging results in a chronic, pro-inflammatory state which can promote and exacerbate age-associated diseases. In contrast, physical activity in older adults improves whole body health, protects against disease, and reduces inflammation, but the elderly are less active making it difficult to disentangle the effects of aging from a sedentary lifestyle. To interrogate this interaction, we analyzed peripheral blood collected at rest and post-exercise from 68 healthy younger and older donors that were either physically active aerobic exercisers or chronically sedentary. Subjects were profiled for 44 low-abundance cytokines, chemokines and growth factors in peripheral blood. At rest, we found that regular physical activity had no impact on the age-related elevation in circulating IL-18, eotaxin, GRO, IL-8, IP-10, PDGF-AA or RANTES. Similarly, there was no impact of physical activity on the age-related reduction in V[[EGF]], [[EGF]] or IL-12 (p70). However, older exercisers had lower resting plasma fractalkine, IL-3, IL-6 and TNF-α compared to sedentary older adults. In contrast to our resting characterization, blood responses following acute exercise produced more striking difference between groups. Physically active younger and older subjects increased over 50% of the analyzed factors in their blood which resulted in both unique and overlapping exercise signatures. However, sedentary individuals, particularly the elderly, had few detectable changes in response to exercise. Overall, we show that long term physical activity has a limited effect on age-associated changes in basal cytokines and chemokines in the healthy elderly, yet physically active individuals exhibit a broader induction of factors post-exercise irrespective of age.
 


|keywords=* growth factors
|keywords=* ACVR1
* human aging
* activin A
* inflammation
* cell senescence
* physical activity
* fibrodysplasia ossificans progressiva
|full-text-url=https://sci-hub.do/10.1093/gerona/glaa310
* progeroid syndrome
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6966325
}}
}}
==F3==
==ADA==


{{medline-entry
{{medline-entry
|title=A Comprehensive Analysis of Age and Gender Effects in European Portuguese Oral Vowels.
|title=Adenosine Metabolism in the Cerebral Cortex from Several Mice Models during Aging.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/33293174
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/33023260
|abstract=The knowledge about the age effects in speech acoustics is still disperse and incomplete. This study extends the analyses of the effects of age and gender on acoustics of European Portuguese (EP) oral vowels, in order to complement initial studies with limited sets of acoustic parameters, and to further investigate unclear or inconsistent results. A database of EP vowels produced by a group of 113 adults, aged between 35 and 97, was used. Duration, fundamental frequency (f0), formant frequencies (F1 to [[F3]]), and a selection of vowel space metrics (F1 and F2 range ratios, vowel articulation index [VAI] and formant centralization ratio [FCR]) were analyzed. To avoid the arguable division into age groups, the analyses considered age as a continuous variable. The most relevant age-related results included: vowel duration increase in both genders; a general tendency to formant frequencies decrease for females; changes that were consistent with vowel centralization for males, confirmed by the vowel space acoustic indexes; and no evidence of [[F3]] decrease with age, in both genders. This study has contributed to knowledge on aging speech, providing new information for an additional language. The results corroborated that acoustic characteristics of speech change with age and present different patterns between genders.
 


|keywords=* Acoustic
|keywords=* adenosine metabolism
* Aging voice
* aging
* European Portuguese
* animal models
* Oral vowel
* glutamate
|full-text-url=https://sci-hub.do/10.1016/j.jvoice.2020.10.021
* purinergic signaling
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7582336
}}
}}
==FES==
==ADAM10==


{{medline-entry
{{medline-entry
|title=An outpatient Tai Chi program: Effects on veterans' functional outcomes.
|title=NKG2D Ligand Shedding in Response to Stress: Role of [[ADAM10]].
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/33241873
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32269567
|abstract=To evaluate the effectiveness of an evidence-based 12-week Tai Chi course designed to improve balance and physical function in a population of older veterans. Community dwelling veterans of all ages with gait and balance problems were invited to participate in the Tai Chi program. Participants completed the Berg Balance Scale (BBS), the Timed Up and Go (TUG) test, and the Falls Efficacy Scale-International ([[FES]]-I) at baseline and again at the end of the program. Descriptive statistics were used to summarize study participants' characteristics. The change from baseline to the end of the 12-week program was calculated for each of the three primary outcome variables (BBS, TUG, [[FES]]-I). Twenty-two veterans, aged 58 years and above, with perceived gait and/or balance issues were enrolled in the program with completion by 11 veterans. Veterans who completed their final assessments showed the BBS, improved significantly (p = 0.004) from baseline to the 12-week assessment. The TUG scores improved by a median of 1.3 s (p = 0.022). There was not a significant change in the [[FES]]-I. Preliminary findings provide evidence of the effectiveness of a 12-week Tai Chi program to improve functional outcomes for older veterans with mild to moderate gait and balance problems.
 


|keywords=* Tai Chi
|keywords=* ADAM10
* balance
* NKG2D
* exercise
* NKG2D ligands
* gait
* cancer
* geriatrics
* chemotherapy
|full-text-url=https://sci-hub.do/10.1111/nuf.12532
* senescence
* shedding
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7109295
}}
}}
==FH==
{{medline-entry
{{medline-entry
|title=Genetic Factors of Alzheimer's Disease Modulate How Diet is Associated with Long-Term Cognitive Trajectories: A UK Biobank Study.
|title=Chronic Mild Stress Modified Epigenetic Mechanisms Leading to Accelerated Senescence and Impaired Cognitive Performance in Mice.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/33252089
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32050516
|abstract=Fluid intelligence (FI) involves abstract problem-solving without prior knowledge. Greater age-related FI decline increases Alzheimer's disease (AD) risk, and recent studies suggest that certain dietary regimens may influence rates of decline. However, it is uncertain how long-term food consumption affects FI among adults with or without familial history of AD ([[FH]]) or APOE4 (ɛ4). Observe how the total diet is associated with long-term cognition among mid- to late-life populations at-risk and not-at-risk for AD. Among 1,787 mid-to-late-aged adult UK Biobank participants, 10-year FI trajectories were modeled and regressed onto the total diet based on self-reported intake of 49 whole foods from a Food Frequency Questionnaire (FFQ). Daily cheese intake strongly predicted better FIT scores over time ([[FH]]-: β= 0.207, p < 0.001; ɛ4-: β= 0.073, p = 0.008; ɛ4+: β= 0.162, p = 0.001). Alcohol of any type daily also appeared beneficial (ɛ4+: β= 0.101, p = 0.022) and red wine was sometimes additionally protective ([[FH]]+: β= 0.100, p = 0.014; ɛ4-: β= 0.59, p = 0.039). Consuming lamb weekly was associated with improved outcomes ([[FH]]-: β= 0.066, p = 0.008; ɛ4+: β= 0.097, p = 0.044). Among at risk groups, added salt correlated with decreased performance ([[FH]]+: β= -0.114, p = 0.004; ɛ4+: β= -0.121, p = 0.009). Modifying meal plans may help minimize cognitive decline. We observed that added salt may put at-risk individuals at greater risk, but did not observe similar interactions among [[FH]]- and AD- individuals. Observations further suggest in risk status-dependent manners that adding cheese and red wine to the diet daily, and lamb on a weekly basis, may also improve long-term cognitive outcomes.


|keywords=* APOE4
|mesh-terms=* ADAM10 Protein
* Aging
* Aging
* Mediterranean diet
* Amyloid Precursor Protein Secretases
* cognitive decline
* Animals
* functional food
* Cognition
* lamb
* Epigenesis, Genetic
* nutrition policy
* Female
* preventive medicine
* Glial Fibrillary Acidic Protein
* red wine
* Glycogen Synthase Kinase 3 beta
* salt
* Mechanistic Target of Rapamycin Complex 1
|full-text-url=https://sci-hub.do/10.3233/JAD-201058
* Membrane Proteins
* Mice
* MicroRNAs
* NF-kappa B
* Reactive Oxygen Species
* Signal Transduction
* Stress, Psychological
|keywords=* Alzheimer’s disease
* SAMP8
* SAMR1
* age-related cognitive decline
* autophagy
* cognition
* epigenetics
* inflammation
* oxidative stress
* senescence
* stress
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7037343
}}
}}
==FOXO3==
==ADAM17==


{{medline-entry
{{medline-entry
|title=The DNA methylation of [[FOXO3]] and TP53 as a blood biomarker of late-onset asthma.
|title=ACE2/[[ADAM17]]/TMPRSS2 Interplay May Be the Main Risk Factor for COVID-19.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/33298101
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/33117379
|abstract=Late-onset asthma (LOA) is beginning to account for an increasing proportion of asthma patients, which is often underdiagnosed in the elderly. Studies on the possible relations between aging-related genes and LOA contribute to the diagnosis and treatment of LOA. Forkhead Box O3 ([[FOXO3]]) and TP53 are two classic aging-related genes. DNA methylation varies greatly with age which may play an important role in the pathogenesis of LOA. We supposed that the differentially methylated sites of [[FOXO3]] and TP53 associated with clinical phenotypes of LOA may be useful biomarkers for the early screening of LOA. The mRNA expression and DNA methylation of [[FOXO3]] and TP53 in peripheral blood of 43 LOA patients (15 mild LOA, 15 moderate LOA and 13 severe LOA) and 60 healthy controls (HCs) were determined. The association of methylated sites with age was assessed by Cox regression to control the potential confounders. Then, the correlation between differentially methylated sites (DMSs; p-value < 0.05) and clinical lung function in LOA patients was evaluated. Next, candidate DMSs combining with age were evaluated to predict LOA by receiver operating characteristic (ROC) analysis and principal components analysis (PCA). Finally, HDM-stressed asthma model was constructed, and DNA methylation inhibitor 5-Aza-2'-deoxycytidine (5-AZA) were used to determine the regulation of DNA methylation on the expression of [[FOXO3]] and TP53. Compared with HCs, the mRNA expression and DNA methylation of [[FOXO3]] and TP53 vary significantly in LOA patients. Besides, 8 DMSs from LOA patients were identified. Two of the DMSs, chr6:108882977 ([[FOXO3]]) and chr17:7591672 (TP53), were associated with the severity of LOA. The combination of the two DMSs and age could predict LOA with high accuracy (AUC values = 0.924). In HDM-stressed asthma model, DNA demethylation increased the expression of [[FOXO3]] and P53. The mRNA expression of [[FOXO3]] and TP53 varies significantly in peripheral blood of LOA patients, which may be due to the regulation of DNA methylation. [[FOXO3]] and TP53 methylation is a suitable blood biomarker to predict LOA, which may be useful targets for the risk diagnosis and clinical management of LOA.


|keywords=* Aging
|mesh-terms=* ADAM17 Protein
* DNA methylation
* Aged
* FOXO3
* Aging
* Late-onset asthma
* Angiotensin-Converting Enzyme 2
* TP53
* Betacoronavirus
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7726856
* COVID-19
* Comorbidity
* Coronavirus Infections
* Female
* Humans
* Male
* Pandemics
* Peptidyl-Dipeptidase A
* Pneumonia, Viral
* Receptors, Interleukin-6
* Risk Factors
* SARS-CoV-2
* Serine Endopeptidases
* Tumor Necrosis Factor-alpha
|keywords=* ACE2
* ADAM17
* COVID-19 pathophysiology
* SARS-CoV-2
* TMPRSS2
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7575774
}}
}}
==FOXP1==
==ADH5==


{{medline-entry
{{medline-entry
|title=GATA6 regulates aging of human mesenchymal stem/stromal cells.
|title=Can Serum Nitrosoproteome Predict Longevity of Aged Women?
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/33252174
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/33260845
|abstract=Cellular reprogramming forcing the expression of pluripotency markers can reverse aging of cells but how molecular mechanisms through which reprogrammed cells alter aging-related cellular activities still remain largely unclear. In this study, we reprogrammed human synovial fluid-derived mesenchymal stem cells (MSCs) into induced pluripotent stem cells (iPSCs) using six reprogramming factors and reverted the iPSCs back to MSCs, as an approach to cell rejuvenation. Using the parental and reprogrammed MSCs as control nonrejuvenated and rejuvenated cells, respectively, for comparative analysis, we found that aging-related activities were greatly reduced in reprogrammed MSCs compared with those in their parental lines, indicating reversal of cell aging. Global transcriptome analysis revealed differences in activities of regulatory networks associated with inflammation and proliferation. Mechanistically, we demonstrated that, compared with control cells, the expression of GATA binding protein 6 (GATA6) in reprogrammed cells was attenuated, resulting in an increase in the activity of sonic hedgehog signaling and the expression level of downstream forkhead box P1 ([[FOXP1]]), in turn ameliorating cellular hallmarks of aging. Lower levels of GATA6 expression were also found in cells harvested from younger mice or lower passage cultures. Our findings suggest that GATA6 is a critical regulator increased in aged MSCs that controls the downstream sonic hedgehog signaling and [[FOXP1]] pathway to modulate cellular senescence and aging-related activities.
 


|keywords=* aging
|keywords=* aging
* cell signaling
* cardiovascular disease
* mesenchymal stem cells
* muscle atrophy
* reprogramming
* nitrosative stress
* transcription factors
* proteomics
|full-text-url=https://sci-hub.do/10.1002/stem.3297
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7731247
}}
}}
==GC==
==ADM==


{{medline-entry
{{medline-entry
|title=Body Size and Cuticular Hydrocarbons as Larval Age Indicators in the Forensic Blow Fly, Chrysomya albiceps (Diptera: Calliphoridae).
|title=Assessment of age-related differences in decomposition-based quantitative EMG in the intrinsic hand muscles: A multivariate approach.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/33274739
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32693193
|abstract=Chrysomya albiceps (Wiedemann 1819) is one of the most important insects in forensic entomology. Its larval developmental and survival rates are influenced by nutritional resources, temperature, humidity, and geographical regions. The present study investigated the possibility of relying on body size and cuticular hydrocarbon composition as indicators for age estimation of the different larval instars of C. albiceps. Larvae were maintained in standardized laboratory conditions at different experimental temperatures. All larval instars (first, second, and third) were randomly collected for measuring their body sizes and for estimating their cuticular hydrocarbons at different rearing temperatures (30, 35, 40, and 45°C) using gas chromatography-mass spectrometry ([[GC]]-MS). Results indicated that the duration of larval stage was temperature dependent as it gradually decreased on increasing the rearing temperature (30, 35, and 40°C) except 45°C at which larval development was ceased. In contrary, larval body size, in terms of length, width, and weight, was temperature dependent as it gradually increased with larval development on increasing rearing temperature except at 45°C at which larval development was ceased. The [[GC]]-MS showed a significant difference in the extracted components of cuticular hydrocarbons between different larval instars reared in the same temperature and between the same larval instar that reared at different temperatures. Furthermore, the highest and lowest amounts of cuticular hydrocarbons were detected at 35 and 40°C, respectively. Overall, larval body size and cuticular hydrocarbon components were temperature dependent within the range 30-40°C, which may suggest them as possible reliable age indicators for estimating the postmortem interval in the field of medicolegal entomology.
 


|keywords=*  
|keywords=* Aging
          Chrysomya albiceps
* Decomposition-based quantitative electromyography (DQEMG)
       
* Hand muscle
* body size
* Jiggle
* cuticular hydrocarbon
* Motor unit potential (MUP)
* forensic
* Multivariate
* larval longevity
|full-text-url=https://sci-hub.do/10.1016/j.clinph.2020.06.017
|full-text-url=https://sci-hub.do/10.1093/jme/tjaa256
}}
{{medline-entry
|title=Evaluation of transcriptional levels of the natriuretic peptides, endothelin-1, adrenomedullin, their receptors and long non-coding RNAs in rat cardiac tissue as cardiovascular biomarkers of aging.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31629715
 
 
|keywords=* ADM system
* Aging
* Biomarkers
* ET-1system
* LncRNA
* NP system
|full-text-url=https://sci-hub.do/10.1016/j.peptides.2019.170173
}}
}}
==GNE==
==ADORA2B==


{{medline-entry
{{medline-entry
|title=Aberrant mitochondrial morphology and function associated with impaired mitophagy and DNM1L-MAPK/ERK signaling are found in aged mutant Parkinsonian LRRK2  mice.
|title=Adenosine A2B receptor: A pathogenic factor and a therapeutic target for sensorineural hearing loss.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/33300446
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/33131093
|abstract=Mitochondrial dysfunction causes energy deficiency and nigrostriatal neurodegeneration which is integral to the pathogenesis of Parkinson disease (PD). Clearance of defective mitochondria involves fission and ubiquitin-dependent degradation via mitophagy to maintain energy homeostasis. We hypothesize that LRRK2 (leucine-rich repeat kinase 2) mutation disrupts mitochondrial turnover causing accumulation of defective mitochondria in aging brain. We found more ubiquitinated mitochondria with aberrant morphology associated with impaired function in aged (but not young) LRRK2  knockin mutant mouse striatum compared to wild-type (WT) controls. LRRK2  mutant mouse embryonic fibroblasts (MEFs) exhibited reduced MAP1LC3/LC3 activation indicating impaired macroautophagy/autophagy. Mutant MEFs under FCCP-induced (mitochondrial uncoupler) stress showed increased LC3-aggregates demonstrating impaired mitophagy. Using a novel flow cytometry assay to quantify mitophagic rates in MEFs expressing photoactivatable [i]mito[/i]-PAmCherry, we found significantly slower mitochondria clearance in mutant cells. Specific LRRK2 kinase inhibition using [[GNE]]-7915 did not alleviate impaired mitochondrial clearance suggesting a lack of direct relationship to increased kinase activity alone. DNM1L/Drp1 knockdown in MEFs slowed mitochondrial clearance indicating that DNM1L is a prerequisite for mitophagy. DNM1L knockdown in slowing mitochondrial clearance was less pronounced in mutant MEFs, indicating preexisting impaired DNM1L activation. DNM1L knockdown disrupted mitochondrial network which was more evident in mutant MEFs. DNM1L-Ser616 and MAPK/ERK phosphorylation which mediate mitochondrial fission and downstream mitophagic processes was apparent in WT using FCCP-induced stress but not mutant MEFs, despite similar total MAPK/ERK and DNM1L levels. In conclusion, aberrant mitochondria morphology and dysfunction associated with impaired mitophagy and DNM1L-MAPK/ERK signaling are found in mutant LRRK2 MEFs and mouse brain.  ATP: adenosine triphosphate; BAX: BCL2-associated X protein; CDK1: cyclin-dependent kinase 1; CDK5: cyclin-dependent kinase 5; CQ: chloroquine; CSF: cerebrospinal fluid; DNM1L/DRP1: dynamin 1-like; ELISA: enzyme-linked immunosorbent assay; FACS: fluorescence-activated cell sorting; FCCP: carbonyl cyanide-4-(trifluoromethoxy)phenylhydrazone; GAPDH: glyceraldehyde-3-phosphate dehydrogenase; LAMP2A: lysosomal-associated membrane protein 2A; LRRK2: leucine-rich repeat kinase 2; MAP1LC3/LC3: microtubule-associated protein 1 light chain 3; MAPK1/ERK2: mitogen-activated protein kinase 1; MEF: mouse embryonic fibroblast; MFN1: mitofusin 1; MMP: mitochondrial membrane potential; PAmCherry: photoactivatable-mCherry; PD: Parkinson disease; PINK1: PTEN induced putative kinase 1; PRKN/PARKIN: parkin RBR E3 ubiquitin protein ligase; RAB10: RAB10, member RAS oncogene family; RAF: v-raf-leukemia oncogene; SNCA: synuclein, alpha; TEM: transmission electron microscopy; VDAC: voltage-dependent anion channel; WT: wild type; SQSTM1/p62: sequestosome 1.
 


|keywords=* Aging
|keywords=* ADA-deficiency
* Dnm1l/DRP1
* adenosine deaminase deficiency
* SQSTM1/p62
* aging
* knockin mice
* myelin protein zero
* macroautophagy
* myelination
* mitochondria dysfunction
|full-text-url=https://sci-hub.do/10.1096/fj.202000939R
* mitochondrial fission
* mitophagy
* parkinson disease
* ubiquitination
|full-text-url=https://sci-hub.do/10.1080/15548627.2020.1850008
}}
}}
==GRN==
==ADRA2A==


{{medline-entry
{{medline-entry
|title=Stressful development: Integrating endoderm development, stress, and longevity.
|title=α2A-Adrenergic Receptor Inhibits the Progression of Cervical Cancer Through Blocking PI3K/AKT/mTOR Pathway.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/33307045
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/33116632
|abstract=In addition to performing digestion and nutrient absorption, the intestine serves as one of the first barriers to the external environment, crucial for protecting the host from environmental toxins, pathogenic invaders, and other stress inducers. The gene regulatory network ([[GRN]]) governing embryonic development of the endoderm and subsequent differentiation and maintenance of the intestine has been well-documented in C. elegans. A key regulatory input that initiates activation of the embryonic [[GRN]] for endoderm and mesoderm in this animal is the maternally provided SKN-1 transcription factor, an ortholog of the vertebrate Nrf-1 and -2, which, like C. elegans SKN-1, perform conserved regulatory roles in mediating a variety of stress responses across metazoan phylogeny. Other key regulatory factors in early gut development also participate in stress response as well as in innate immunity and aging and longevity. In this review, we discuss the intersection between genetic nodes that mediate endoderm/intestine differentiation and regulation of stress and homeostasis. We also consider how direct signaling from the intestine to the germline, in some cases involving SKN-1, facilitates heritable epigenetic changes, allowing transmission of adaptive stress responses across multiple generations. These connections between regulation of endoderm/intestine development and stress response mechanisms suggest that varying selective pressure exerted on the stress response pathways may influence the architecture of the endoderm [[GRN]], thereby leading to genetic and epigenetic variation in early embryonic [[GRN]] regulatory events.
 


|keywords=* Caenorhabditis elegans
|keywords=* ADRA2A
* Embryonic development
* PI3K/Akt/mTOR pathway
* Epigenetics inheritance
* cervical cancer
* Innate immunity
* metastasis
* Longevity
* proliferation
* Pleiotropy
* senescence
* Stress
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7574911
|full-text-url=https://sci-hub.do/10.1016/j.ydbio.2020.12.002
}}
}}
==GSTM1==
==AFM==


{{medline-entry
{{medline-entry
|title=The effects of everyday-life exposure to polycyclic aromatic hydrocarbons on biological age indicators.
|title=Photocatalytic aging process of Nano-TiO  coated polypropylene microplastics: Combining atomic force microscopy and infrared spectroscopy ([[AFM]]-IR) for nanoscale chemical characterization.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/33272294
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/33080556
|abstract=Further knowledge on modifiable aging risk factors is required to mitigate the increasing burden of age-related diseases in a rapidly growing global demographic of elderly individuals. We explored the effect of everyday exposure to polycyclic aromatic hydrocarbons (PAHs), which are fundamental constituents of air pollution, on cellular biological aging. This was determined via the analysis of leukocyte telomere length (LTL), mitochondrial DNA copy number (LmtDNAcn), and by the formation of anti-benzo[a]pyrene diolepoxide (B[a]PDE-DNA) adducts. The study population consisted of 585 individuals living in North-East Italy. PAH exposure (diet, indoor activities, outdoor activities, traffic, and residential exposure) and smoking behavior were assessed by questionnaire and anti-B[a]PDE-DNA by high-performance-liquid-chromatography. LTL, LmtDNAcn and genetic polymorphisms [glutathione S-transferase M1 and T1 ([[GSTM1]]; GSTT1)] were measured by polymerase chain reaction. Structural equation modelling analysis evaluated these complex relationships. Anti-B[a]PDE-DNA enhanced with PAH exposure (p = 0.005) and active smoking (p = 0.0001), whereas decreased with detoxifying [[GSTM1]] (p = 0.021) and in females (p = 0.0001). Subsequently, LTL and LmtDNAcn reduced with anti-B[a]PDE-DNA (p = 0.028 and p = 0.018), particularly in males (p = 0.006 and p = 0.0001). Only LTL shortened with age (p = 0.001) while elongated with active smoking (p = 0.0001). Besides this, the most significant determinants of PAH exposure that raised anti-B[a]PDE-DNA were indoor and diet (p = 0.0001), the least was outdoor (p = 0.003). New findings stemming from our study suggest that certain preventable everyday life exposures to PAHs reduce LTL and LmtDNAcn. In particular, the clear association with indoor activities, diet, and gender opens new perspectives for tailored preventive measures in age-related diseases. Everyday life exposure to polycyclic aromatic hydrocarbons reduces leukocyte telomere length and mitochondrial DNA copy number through anti-B[a]PDE-DNA adduct formation.
 


|keywords=* Biological aging
|keywords=* AFM-IR
* DNA adduct
* Aging process
* Mitochondrial DNA copy number
* Microplastics
* Polycyclic aromatic hydrocarbon
* Nanoscale characterization
* Structural equation modelling
* Polypropylene
* Telomere length
|full-text-url=https://sci-hub.do/10.1016/j.jhazmat.2020.124159
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7713168
}}
}}
==GZMK==
{{medline-entry
|title=Nanoscale infrared, thermal and mechanical properties of aged microplastics revealed by an atomic force microscopy coupled with infrared spectroscopy ([[AFM]]-IR) technique.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32702545
 


|keywords=* AFM-IR
* Aging process
* Mechanical properties
* Microplastics (MPs)
* Thermal analysis
|full-text-url=https://sci-hub.do/10.1016/j.scitotenv.2020.140944
}}
{{medline-entry
{{medline-entry
|title=Comprehensive Profiling of an Aging Immune System Reveals Clonal [[GZMK]]  CD8  T Cells as Conserved Hallmark of Inflammaging.
|title=Detecting zeta potential of polydimethylsiloxane (PDMS) in electrolyte solutions with atomic force microscope.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/33271118
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32521351
|abstract=Systematic understanding of immune aging on a whole-body scale is currently lacking. We characterized age-associated alterations in immune cells across multiple mouse organs using single-cell RNA and antigen receptor sequencing and flow cytometry-based validation. We defined organ-specific and common immune alterations and identified a subpopulation of age-associated granzyme K ([[GZMK]])-expressing CD8  T (Taa) cells that are distinct from T effector memory (Tem) cells. Taa cells were highly clonal, had specific epigenetic and transcriptional signatures, developed in response to an aged host environment, and expressed markers of exhaustion and tissue homing. Activated Taa cells were the primary source of [[GZMK]], which enhanced inflammatory functions of non-immune cells. In humans, proportions of the circulating [[GZMK]] CD8  T cell population that shares transcriptional and epigenetic signatures with mouse Taa cells increased during healthy aging. These results identify [[GZMK]]  Taa cells as a potential target to address age-associated dysfunctions of the immune system.
 


|keywords=* Aging
|keywords=* AFM
* CD8 T cells
* Air plasma treatment
* CITE-seq
* Liquid aging
* granzyme K
* PDMS
* immune system
* Zeta potential
* inflammaging
|full-text-url=https://sci-hub.do/10.1016/j.jcis.2020.05.061
* single-cell ATAC-sequencing
* single-cell BCR-sequencing
* single-cell RNA-sequencing
* single-cell TCR-sequencing
|full-text-url=https://sci-hub.do/10.1016/j.immuni.2020.11.005
}}
}}
==HES1==
{{medline-entry
|title=Recent Applications of Advanced Atomic Force Microscopy in Polymer Science: A Review.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32429499
 


|keywords=* AFM-IR
* blends
* nanoscale characterization
* polymer aging
* polymer composites
* polymers
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7284686
}}
{{medline-entry
{{medline-entry
|title=A Single-Cell Transcriptomic Atlas of Human Skin Aging.
|title=Active fractions of mannoproteins derived from yeast cell wall stimulate innate and acquired immunity of adult and elderly dogs.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/33238152
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32288071
|abstract=Skin undergoes constant self-renewal, and its functional decline is a visible consequence of aging. Understanding human skin aging requires in-depth knowledge of the molecular and functional properties of various skin cell types. We performed single-cell RNA sequencing of human eyelid skin from healthy individuals across different ages and identified eleven canonical cell types, as well as six subpopulations of basal cells. Further analysis revealed progressive accumulation of photoaging-related changes and increased chronic inflammation with age. Transcriptional factors involved in the developmental process underwent early-onset decline during aging. Furthermore, inhibition of key transcription factors [[HES1]] in fibroblasts and KLF6 in keratinocytes not only compromised cell proliferation, but also increased inflammation and cellular senescence during aging. Lastly, we found that genetic activation of [[HES1]] or pharmacological treatment with quercetin alleviated cellular senescence of dermal fibroblasts. These findings provide a single-cell molecular framework of human skin aging, providing a rich resource for developing therapeutic strategies against aging-related skin disorders.
 


|keywords=* HES1
|keywords=* AFM, active fraction of mannoproteins
* KLF6
* ALP, alkaline phosphatase
* aging
* ALT, alanine aminotransferase
* fibroblast
* Ageing
* keratinocyte
* CBC, complete blood count
* quercetin
* CD21+, B lymphocyte
* senescence
* CD4+, auxiliary T lymphocyte
* single-cell RNA sequencing
* CD5+, total T lymphocyte
* skin
* CD8+, cytotoxic lymphocyte
|full-text-url=https://sci-hub.do/10.1016/j.devcel.2020.11.002
* CO, cells only
* Canine
* DCHT, delayed cutaneous hypersensitivity test
* FOSs, fructooligosaccharides
* GALT, gut-associated lymphoid tissue
* IL-12, interleukin 12
* IgA, immunoglobulin A
* Immunosenescence
* LPS, bacterial lipopolysaccharide
* MOSs, mannanoligosaccharides
* NADPH, reduced nicotinamide adenine dinucleotide phosphate
* NO, nitrogen monoxide
* NOS, nitric oxide synthase
* OD, optical density
* PMA, phorbol myristate acetate
* Saccharomyces cerevisiae
* Senescence
* TNF-α, tumour necrosis factor alpha
* Th1, helper T lymphocyte
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7126846
}}
}}
==HGS==
{{medline-entry
|title=The Effect of Waste Engine Oil and Waste Polyethylene on UV Aging Resistance of Asphalt.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32155867


{{medline-entry
|title=Handgrip strength asymmetry is associated with future falls in older Americans.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/33247424
|abstract=Examining handgrip strength ([[HGS]]) asymmetry could extend the utility of handgrip dynamometers for screening future falls. We sought to determine the associations of [[HGS]] asymmetry on future falls in older Americans. The analytic sample included 10,446 adults aged at least 65 years from the 2006-2016 waves of the Health and Retirement Study. Falls were self-reported. A handgrip dynamometer measured [[HGS]]. The highest [[HGS]] on each hand was used for determining [[HGS]] asymmetry ratio: (non-dominant [[HGS]]/dominant [[HGS]]). Those with [[HGS]] asymmetry ratio < 1.0 had their ratio inverted to make all [[HGS]] asymmetry ratios ≥ 1.0. Participants were categorized into asymmetry groups based on their inverted [[HGS]] asymmetry ratio: (1) 0.0-10.0%, (2) 10.1-20.0%, (3) 20.1-30.0%, and (4) > 30.0%. Generalized estimating equations were used for the analyses. Every 0.10 increase in [[HGS]] asymmetry ratio was associated with 1.26 (95% confidence interval (CI) 1.07-1.48) greater odds for future falls. Relative to those with [[HGS]] asymmetry 0.0-10.0%, participants with [[HGS]] asymmetry > 30.0% had 1.15 (CI 1.01-1.33) greater odds for future falls; however, the associations were not significant for those with [[HGS]] asymmetry 10.1-20.0% (odds ratio: 1.06; CI 0.98-1.14) and 20.1-30.0% (odds ratio: 1.10; CI 0.99-1.22). Compared to those with [[HGS]] asymmetry 0.0-10.0%, participants with [[HGS]] asymmetry > 10.0% and > 20.0% had 1.07 (CI 1.01-1.16) and 1.12 (CI 1.02-1.22) greater odds for future falls, respectively. Asymmetric [[HGS]], as a possible biomarker of impaired neuromuscular function, may help predict falls. We recommend that [[HGS]] asymmetry be considered in [[HGS]] protocols and fall risk assessments.


|keywords=* Aging
|keywords=* Fourier transform infrared spectroscopy
* Functional laterality
* atomic force microscopy
* Geriatric assessment
* gel permeation chromatography
* Geriatrics
* ultraviolet aging
* Muscle strength dynamometer
* waste engine oil
|full-text-url=https://sci-hub.do/10.1007/s40520-020-01757-z
* waste polyethylene
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7182932
}}
}}
==HR==
{{medline-entry
|title=Mechanical properties measured by atomic force microscopy define health biomarkers in ageing C. elegans.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32098962


{{medline-entry
|mesh-terms=* Aging
|title=Patients with hip fracture and total hip arthroplasty surgery differ in anthropometric, but not cardiovascular screening abnormalities.
* Animal Feed
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/33267795
* Animals
|abstract=With the rising number of hip surgeries, simple and cost-effective tools for surgery risk assessment are warranted. The analysis of heart rate variability ([[HR]]V) may not only provide critical insights into the general frailty of patients with hip surgery, but also allow for better differentiation of health profiles in different hip surgery groups. Using [[HR]]V analysis, the present study compared cardiovascular as well as anthropometric parameters between patients with hip surgery, the hip fracture surgery group (HFS) and the total hip arthroplasty group (THA), and a control group. 71 participants (56.3% women), aged 60-85 years, took part, divided into three groups-patients after hip surgery (21 HFS and 30 THA patients) and a control group (20 participants). Electrocardiogram was recorded at baseline and after the application of a physical stressor (grip strength). A 3 (group) × 2 (time) repeated measures ANOVA, and a chi square test were carried out to test for group differences. Higher weight (p = .002), body mass index (p = .001), and systolic blood pressure (p = .034) were found in THA patients compared to HFS patients. Lower calf circumference (p = .009) and diastolic blood pressure (p = .048) were observed for the HFS group compared to the control group. For cardiovascular parameters, significant differences emerged between the HFS group and the control group in [[HR]] (p = .005), SDNN (p = .034) and SD2 (p = .012). No significant differences in cardiovascular parameters were observed between the two hip surgery groups: neither at baseline nor during stressor recovery. While [[HR]]V seems to differentiate well between HFS patients and controls, more research with larger samples is needed to scrutinize similaritites and differences in cardiovascular profiles between HFS and THA patients.
* Bacillus subtilis
* Biomarkers
* Caenorhabditis elegans
* Caenorhabditis elegans Proteins
* Comamonas
* Escherichia coli
* Forkhead Transcription Factors
* Hot Temperature
* Insulin
* Microbiota
* Microscopy, Atomic Force
* Mutation
* Receptor, Insulin
* Signal Transduction
* Ultraviolet Rays


|keywords=* Aging
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7042263
* Cardiovascular reactivity
* Heart rate variability
* Hip fracture
* Total hip arthroplasty
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7713041
}}
}}
{{medline-entry
{{medline-entry
|title=Clinical Role of Lung Ultrasound for the Diagnosis and Prognosis of Coronavirus Disease Pneumonia in Elderly Patients: A Pivotal Study.
|title=Nanomechanical insights: Amyloid beta oligomer-induced senescent brain endothelial cells.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/33271558
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31513781
|abstract=Lung ultrasound (LUS) showed a promising role in the diagnosis and monitoring of patients hospitalized for novel coronavirus disease (COVID-19). However, no data are available on its role in elderly patients. The aim of this study was to evaluate the diagnostic and prognostic role of LUS in elderly patients hospitalized for severe acute respiratory syndrome-coronavirus-2 (SARS-CoV-2) pneumonia. Consecutive elderly patients (age >65 years) hospitalized for COVID-19 were enrolled. Demographics, laboratory, comorbidity, and the clinical features of the patients were collected. All patients underwent LUS on admission to the ward. LUS characteristics have been analyzed. Uni- and multivariate analyses to evaluate predictors for in-hospital death were performed. Thirty-seven hospitalized elderly patients (19 men) with a diagnosis of SARS-CoV-2 infection were consecutively enrolled. The median age was 82 years (interquartile range 74.5-93.5). Ultrasound alterations were found in all patients enrolled; inhomogeneous interstitial syndrome with spared areas (91.9%) and pleural alterations (100%) were the most frequent findings. At univariate analysis, LUS score (hazard ratio [[[HR]]] 1.168, 95% CI 1.049-1.301) and pleural effusions ([[HR]] 3.995, 95% CI 1.056-15.110) were associated with in-hospital death. At multivariate analysis, only LUS score ([[HR]] 1.168, 95% CI 1.049-1.301) was independelty associated with in-hospital death. The LUS score's best cutoff for distinguishing patients experiencing in-hospital death was 17 (at multivariate analysis LUS score ≥17, [[HR]] 4.827, 95% CI 1.452-16.040). In-hospital death was significantly different according to the LUS score cutoff of 17 (p = 0.0046). LUS could play a role in the diagnosis and prognosis in elderly patients hospitalized for SARS-CoV-2 infection.


|keywords=* Aging
|mesh-terms=* Alzheimer Disease
* Coronavirus disease
* Amyloid beta-Peptides
* Elderly
* Biomechanical Phenomena
* Lung ultrasound
* Brain
* Severe acute respiratory syndrome-coronavirus-2
* Cell Culture Techniques
|full-text-url=https://sci-hub.do/10.1159/000512209
* Cell Membrane
* Cellular Senescence
* Endothelial Cells
* Endothelium, Vascular
* Humans
* Microscopy, Atomic Force
* Vascular Endothelial Growth Factor A
|keywords=* Amyloid beta oligomer
* Atomic force microscopy
* Brain endothelial cells
* Nanoindentation
* Nanomechanical properties
* Senescence
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6791778
}}
}}
==IRS2==
==AGER==


{{medline-entry
{{medline-entry
|title=Effects of Heshouwuyin on gene expression of the insulin/IGF signalling pathway in rat testis and spermatogenic cells.
|title=Vitamin D3 regulates apoptosis and proliferation in the testis of D-galactose-induced aged rat model.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/33264567
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31575929
|abstract=The Chinese herbal formula Heshouwu decoction (Heshouwuyin) has protective effects on testicular function in aging male rats, but the mechanism is unknown. This study investigated whether Heshouwuyin affects the testicular function of aging rats by regulating the insulin/IGF signalling pathway. Sixteen-month-old male Wistar rats in the Heshouwuyin group and the natural-aging group were orally administered Heshouwuyin granules (0.056 g/kg) or equivalent normal saline for 60 d. The testicular tissue of 12-month-old male Wistar rats was removed as a young control group ([i]n[/i] = 10). The testicular tissue and spermatogenic cells were studied. The immunofluorescence results revealed that the insulin receptor (INSR)- (0.056 ± 0.00548), insulin receptor substrate 1(IRS1)- (0.251 ± 0.031), [[IRS2]] (0.230 ± 0.019)- and insulin-like growth factor 1 (IGF1)-positive cell rate (0.33 ± 0.04) in the aging group was higher than that in the young control group (0.116 ± 0.011, 0.401 ± 0.0256, 0.427 ± 0.031, 0.56 ± 0.031; [i]p[/i] < 0.01), and the IGF-binding protein 3 (IGFBP3)-positive cell rate (0.42 ± 0.024) was lower than that (0.06 ± 0.027) in the young group ([i]p[/i] < 0.01). The intervention of Heshouwuyin reversed the above phenomena. The qPCR and immunoblot results were consistent with those of the immunofluorescence. The same results were obtained in spermatogenic cells. Our research shows that Heshouwuyin can regulate the insulin/IGF signalling pathway to improve testicular function, and provides an experimental basis for further clinical use.
 
|mesh-terms=* Aging
* Animals
* Antioxidants
* Apoptosis
* Cell Proliferation
* Cholecalciferol
* Down-Regulation
* Galactose
* Male
* Oxidative Stress
* Rats
* Spermatogenesis
* Testis


|keywords=* IGF1
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6773724
* IGFBP3
* INSR
* IRS1
* IRS2
* Male reproduction
* senescence
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7717869
}}
}}
==LMNB1==
==AGT==


{{medline-entry
{{medline-entry
|title=Cellular senescence as a response to multiwalled carbon nanotube (MWCNT) exposure in human mesothelial cells.
|title=SQSTM1/p62 and PPARGC1A/PGC-1alpha at the interface of autophagy and vascular senescence.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/33279583
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31441382
|abstract=Cellular senescence is a stable cell cycle arrest induced by diverse triggers, including replicative exhaustion, DNA damaging agents, oncogene activation, oxidative stress, and chromatin disruption. With important roles in aging and tumor suppression, cellular senescence has been implicated also in tumor promotion. Here we show that certain multiwalled carbon nanotubes (MWCNTs), as fiber-like nanomaterials, can trigger cellular senescence in primary human mesothelial cells. Using in vitro approaches, we found manifestation of several markers of cellular senescence, especially after exposure to a long and straight MWCNT. These included inhibition of cell division, senescence-associated heterochromatin foci, senescence-associated distension of satellites, [[LMNB1]] depletion, γH2A.X nuclear panstaining, and enlarged cells exhibiting senescence-associated β-galactosidase activity. Furthermore, genome-wide transcriptome analysis revealed many differentially expressed genes, among which were genes encoding for a senescence-associated secretory phenotype. Our results clearly demonstrate the potential of long and straight MWCNTs to induce premature cellular senescence. This finding may find relevance in risk assessment of workplace safety, and in evaluating MWCNT's use in medicine such as drug carrier, due to exposure effects that might prompt onset of age-related diseases, or even carcinogenesis.


|keywords=* alpha tubulin
* cellular senescence
* mesothelial cells
* microarray analysis
* multiwalled carbon nanotubes
* γH2A.X
|full-text-url=https://sci-hub.do/10.1016/j.mad.2020.111412
}}
{{medline-entry
|title=SIRT1 - a new mammalian substrate of nuclear autophagy.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/33292048
|abstract=Macroautophagic/autophagic degradation of nuclear components (or nuclear autophagy) is a poorly understood area in autophagy research. We previously reported the nuclear lamina protein [[LMNB1]] (lamin B1) as a nuclear autophagy substrate in primary human cells, stimulating the investigation of nuclear autophagy in the mammalian system. We recently reported the sirtuin protein SIRT1 as a new selective substrate of nuclear autophagy in senescence and aging. Upon senescence of primary human cells, SIRT1 degradation is mediated by a direct nuclear SIRT1-LC3 interaction, followed by nucleus-to-cytoplasm shuttling of SIRT1 and autophagosome-lysosome degradation. In vivo, SIRT1 is downregulated by lysosomes in hematopoietic and immune organs upon natural aging in mice and in aged human T cells. Our study identified another substrate of nuclear autophagy and suggests a new strategy to promote SIRT1-mediated health benefits by suppressing its autophagic degradation.


|keywords=* Aging
|keywords=* Aging
* SIRT1
* SQSTM1
* nuclear autophagy
* autophagy
* oxidative stress
* senescence
* senescence
* sirtuin
* vascular biology
|full-text-url=https://sci-hub.do/10.1080/15548627.2020.1860541
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7469683
}}
}}
==MB==
==AHR==


{{medline-entry
{{medline-entry
|title=Probing menstrual bloodstain aging with fluorescence spectroscopy.
|title=Indoles from the commensal microbiota act via the [[AHR]] and IL-10 to tune the cellular composition of the colonic epithelium during aging.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/33279406
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32817517
|abstract=Menstrual blood ([[MB]]) is a common and important type of forensic evidence, especially in sexual assault cases. [[MB]] is composed of peripheral blood (PB), vaginal fluid, and endometrial cells of the uterine wall. In forensic investigations, the differentiation of [[MB]] and PB can determine whether the blood present is a result of tissue damage from an assault or a natural cause and thus help to reconstruct the event. Understanding how menstrual blood changes is necessary to develop a method for bloodstain aging. Fluorescence spectroscopy, a promising spectroscopic method for bloodstain analysis, was used to probe the biochemical changes that occur over time in menstrual bloodstains. It was found that steady-state fluorescence spectra underwent significant changes over first nine hours post deposition. The underlying mechanism of fluorescence changes was proposed to involve the kinetic transformation of three fluorophores: tryptophan, nicotinamide adenine dinucleotide and flavins.
 
|mesh-terms=* Aging
* Animals
* Bacteria
* Cell Differentiation
* Epithelial Cells
* Female
* Goblet Cells
* Indoles
* Interleukin-10
* Interleukins
* Male
* Mice
* Mice, Inbred BALB C
* Mice, Inbred C57BL
* Mice, Knockout
* Microbiota
* Mucus
* Receptors, Aryl Hydrocarbon
* Signal Transduction
|keywords=* aging
* goblet cell
* intestinal homeostasis
* mucus
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7474656
}}
{{medline-entry
|title=Role of the Aryl Hydrocarbon Receptor in Environmentally Induced Skin Aging and Skin Carcinogenesis.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31795255


|keywords=* Aging
|mesh-terms=* Animals
* Analytical methods
* Environmental Exposure
* Blood
* Extracellular Matrix
* Fluorescence spectroscopy
* Humans
* Forensics
* Receptors, Aryl Hydrocarbon
|full-text-url=https://sci-hub.do/10.1016/j.saa.2020.119172
* Skin Aging
* Skin Neoplasms
|keywords=* DNA damage
* UV radiation
* extracellular matrix
* extrinsic skin aging
* melanoma
* particulate matter
* pigmentation
* polycyclic aromatic hydrocarbons
* squamous cell carcinoma
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6928879
}}
}}
==MMD==
==AIP==


{{medline-entry
{{medline-entry
|title=Association between a Deficit Accumulation Frailty Index and Mobility Outcomes in Older Adults: Secondary Analysis of the Lifestyle Interventions and Independence for Elders (LIFE) Study.
|title=[Aryl hydrocarbon receptor interacting protein ([[AIP]]) in human dermis during aging.]
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/33266358
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/33280328
|abstract=Frailty is a geriatric syndrome represented by susceptibility to precipitating health events and reduced functional reserve. Frailty can be difficult to measure in clinical practice and research. One approach to approximate frailty is based on a deficit accumulation approach, which assesses a larger number of less specific measures such as the presence of comorbidities, physical or cognitive assessments, and lab tests, and summarizes these as a frailty index. The objective of this study was to develop such an index using the Lifestyle Interventions and Independence for Elders (LIFE) Study and evaluate the validity of the frailty measure derived based on baseline information via its association with the primary outcomes of the trial, namely major mobility disability ([[MMD]]) and persistent [[MMD]] (p[[MMD]]). Further, this study aimed to evaluate the effectiveness of the physical activity intervention among participants based on their baseline frailty score. Subjects in the LIFE Study were evaluated at baseline for demographics, clinical history, and a battery of physical and cognitive functioning assessments. In total, 75 possible deficits were scored either as present (yes/no) or based on each score's quintiles for score-based assessments. The frailty index was measured as the total sum of deficits divided by the total number of possible deficits on a continuous scale between 0 and 100 (i.e., percent of deficits present). The frailty index was further divided into quintiles for comparison. A proportional hazards model was estimated for the [[MMD]] outcome controlling for other baseline information. A data driven approach was also used to determine relevant cut-offs in the frailty index where the trial intervention appeared to be modified. Among 1635 trial participants, the mean frailty index was 30.4 ± 6.6 and normally distributed. Over 2.5 years of average follow-up, 14.6%, 16.5%, 18.6%, 22.6%, and 27.6% of participants experienced [[MMD]] in quintiles 1-5, respectively. Each 1-unit increase in the frailty index increased the hazard of [[MMD]] by 4% (2-5%), and there was a nearly 2-fold increase in [[MMD]] between the highest and lowest frailty quintiles. Using log-rank criteria, a cut-point at the median was identified. Further, iterations tested for a frailty cut-off and indicated a subgroup beyond the 85th percentile wherein the physical activity intervention appeared to be no longer be effective. This internally derived deficit accumulation frailty index was uniquely able to identify individuals at higher risk of [[MMD]] and p[[MMD]] and showed that along the spectrum of frailty, the physical activity intervention remained effective for the majority of participants.
 
 
|keywords=* AIP
* PCNA
* aging
* fibroblasts
* skin


|keywords=* LIFE Study
* deficit accumulation
* disability
* frailty
* healthy aging
* mobility
* older adults
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7700674
}}
}}
==MSC==
{{medline-entry
|title=Sex-Specific Association between Serum Vitamin D Status and Lipid Profiles: A Cross-Sectional Study of a Middle-Aged and Elderly Chinese Population.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32350171
 


|keywords=* atherogenic index of plasma
* dyslipidaemia
* gerontology
* sex difference
* vitamin D
|full-text-url=https://sci-hub.do/10.3177/jnsv.66.105
}}
{{medline-entry
{{medline-entry
|title=Extracellular vesicles derived from bone marrow mesenchymal stem cells enhance myelin maintenance after cortical injury in aged rhesus monkeys.
|title=The oblique effect: The relationship between profiles of visuospatial preference, cognition, and brain connectomics in older adults.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/33264634
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31654648
|abstract=Cortical injury, such as stroke, causes neurotoxic cascades that lead to rapid death and/or damage to neurons and glia. Axonal and myelin damage in particular, are critical factors that lead to neuronal dysfunction and impair recovery of function after injury and can be exacerbated in the aged brain where white matter damage is prevalent. Therapies that can ameliorate myelin damage and promote repair by targeting oligodendroglia, the cells that produce and maintain myelin, may facilitate recovery after injury, especially in the aged brain where these processes are already compromised. We previously reported that a novel therapeutic, Mesenchymal Stem Cell derived extracellular vesicles ([[MSC]]-EVs), administered intravenously at both 24 h and 14 days after cortical injury reduced microgliosis (Go et al. 2019), reduced neuronal pathology (Medalla et al. 2020), and improved motor recovery (Moore et al. 2019) in aged female rhesus monkeys. Here, we evaluated the effect of treatment with [[MSC]]-EVs on changes in oligodendrocyte maturation and associated myelin markers in the sublesional white matter using immunohistochemistry, confocal microscopy, stereology, qRT-PCR, and ELISA. Compared to vehicle-treated control, EV-treated monkeys showed a reduction in the density of damaged oligodendrocytes. Further, EV-treatment was associated with enhanced myelin maintenance, evidenced by upregulation of myelin-related genes and increases in actively-myelinating oligodendrocytes in in sublesional white matter. These changes in myelination correlate with the rate of motor recovery, suggesting that improved myelin maintenance facilitates this recovery. Overall, our results suggest that EVs act on oligodendrocytes to support myelination and likely improve functional recovery after injury in the aged brain. SIGNIFICANCE: We previously reported that after cortical injury in the aged monkey brain, EVs reduce neuronal pathology (Medalla et al. 2020), microgliosis (Go et al. 2019), and facilitate recovery of function. However, the effect of injury on oligodendrocytes and myelination has not been characterized in the primate brain (Dewar et al. 1999; Sozmen et al. 2012; Zhang et al. 2013). In the present study, we assessed changes in myelination after cortical injury in these same aged monkeys. Our results show, for the first time, that [[MSC]]-EVs support recovery of function after cortical injury by enhancing myelin maintenance in the aged primate brain.


|mesh-terms=* Aged
* Brain
* Cognition
* Connectome
* Diffusion Tensor Imaging
* Executive Function
* Female
* Humans
* Judgment
* Male
* Middle Aged
* Neuropsychological Tests
* Pattern Recognition, Visual
* Spatial Processing
|keywords=* Aging
|keywords=* Aging
* Cortical injury
* Executive function
* Extracellular vesicles
* Oblique effect
* Monkeys
* Perception
* Myelin
* Structural connectivity
* Non-human primates
* Visuospatial processing
* Oligodendrocytes
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6887099
* Stroke
* White matter
|full-text-url=https://sci-hub.do/10.1016/j.expneurol.2020.113540
}}
}}
==ALAS1==
{{medline-entry
{{medline-entry
|title=Rejuvenation of Senescent Endothelial Progenitor Cells by Extracellular Vesicles Derived From Mesenchymal Stromal Cells.
|title=Heterozygous disruption of [[ALAS1]] in mice causes an accelerated age-dependent reduction in free heme, but not total heme, in skeletal muscle and liver.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/33294742
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/33307066
|abstract=Mesenchymal stromal cell ([[MSC]]) transplantation is a form of the stem-cell therapy that has shown beneficial effects for many diseases. The use of stem-cell therapy, including [[MSC]] transplantation, however, has limitations such as the tumorigenic potential of stem cells and the lack of efficacy of aged autologous cells. An ideal therapeutic approach would keep the beneficial effects of [[MSC]] transplantation while circumventing the limitations associated with the use of intact stem cells. This study provides proof-of-concept evidence that [[MSC]]-derived extracellular vesicles represent a promising platform to develop an acellular therapeutic approach that would just do that. Extracellular vesicles are membranous vesicles secreted by [[MSC]]s and contain bioactive molecules to mediate communication between different cells. Extracellular vesicles can be taken up by recipient cells, and once inside the recipient cells, the bioactive molecules are released to exert the beneficial effects on the recipient cells. This study, for the first time to our knowledge, shows that extracellular vesicles secreted by [[MSC]]s recapitulate the beneficial effects of [[MSC]]s on vascular repair and promote blood vessel regeneration after ischemic events. Furthermore, [[MSC]]s from aged donors can be engineered to produce extracellular vesicles with improved regenerative potential, comparable to [[MSC]]s from young donors, thus eliminating the need for allogenic young donors for elderly patients.
 


|keywords=* BM, bone marrow
|keywords=* 5-Aminolevulinate synthase 1 (ALAS1)
* CVD, cardiovascular disease
* 5-Aminolevulinic acid (ALA)
* EC, endothelial cell
* Aging
* EPC, endothelial progenitor cell
* Free heme
* EV, extracellular vesicle
* Liver
* FBS, fetal bovine serum
* Skeletal muscle
* MEM, minimum essential medium
|full-text-url=https://sci-hub.do/10.1016/j.abb.2020.108721
* MI, myocardial infarction
* MSC, mesenchymal stromal cell
* NTA, nanotracking analysis
* PBS, phosphate-buffered saline
* TEV, tailored extracellular vesicle
* VEGF, vascular endothelial growth factor
* acellular
* angiogenesis
* extracellular vesicles
* lin− BMC, lineage negative bone marrow cell
* miR, microRNA
* qPCR, quantitative transcription polymerase chain reaction
* regeneration
* senescence
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7691285
}}
}}
==MYSM1==
==ALB==


{{medline-entry
{{medline-entry
|title=[[MYSM1]] Suppresses Cellular Senescence and the Aging Process to Prolong Lifespan.
|title=Effects of Age on Inflammatory Profiles and Nutrition/Energy Metabolism in Domestic Cats.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/33240758
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/33262938
|abstract=Aging is a universal feature of life that is a major focus of scientific research and a risk factor in many diseases. A comprehensive understanding of the cellular and molecular mechanisms of aging are critical to the prevention of diseases associated with the aging process. Here, it is shown that [[MYSM1]] is a key suppressor of aging and aging-related pathologies. [[MYSM1]] functionally represses cellular senescence and the aging process in human and mice primary cells and in mice organs. [[MYSM1]] mechanistically attenuates the aging process by promoting DNA repair processes. Remarkably, [[MYSM1]] deficiency facilitates the aging process and reduces lifespan, whereas [[MYSM1]] over-expression attenuates the aging process and increases lifespan in mice. The functional role of [[MYSM1]] is demonstrated in suppressing the aging process and prolonging lifespan. [[MYSM1]] is a key suppressor of aging and may act as a potential agent for the prevention of aging and aging-associated diseases.
 


|keywords=* DNA repair
|keywords=* M/L ratio
* Myb‐like, SWIRM, and MPN domains‐containing protein 1 (MYSM1)
* SAA
* aging
* aging
* senescence
* domestic cats
* senescence‐associated secretory phenotype (SASP)
* obesity
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7675055
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7695597
}}
}}
==NLRP3==
==ALK==


{{medline-entry
{{medline-entry
|title=Innate and Adaptive Immunity in Aging and Longevity: The Foundation of Resilience.
|title=Catalog of Lung Cancer Gene Mutations Among Chinese Patients.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/33269094
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32850378
|abstract=The interrelation of the processes of immunity and senescence now receives an unprecedented emphasis during the COVID-19 pandemic, which brings to the fore the critical need to combat immunosenescence and improve the immune function and resilience of older persons. Here we review the historical origins and the current state of the science of innate and adaptive immunity in aging and longevity. From the modern point of view, innate and adaptive immunity are not only affected by aging but also are important parts of its underlying mechanisms. Excessive levels or activity of antimicrobial peptides, C-reactive protein, complement system, TLR/NF-κB, cGAS/STING/IFN 1,3 and AGEs/RAGE pathways, myeloid cells and [[NLRP3]] inflammasome, declined levels of NK cells in innate immunity, thymus involution and decreased amount of naive T-cells in adaptive immunity, are biomarkers of aging and predisposition factors for cellular senescence and aging-related pathologies. Long-living species, human centenarians, and women are characterized by less inflamm-aging and decelerated immunosenescence. Despite recent progress in understanding, the harmonious theory of immunosenescence is still developing. Geroprotectors targeting these mechanisms are just emerging and are comprehensively discussed in this article.
 


|keywords=* adaptive immunity
|keywords=* China
* aging
* aging
* innate immunity
* gene mutation
* longevity
* lung cancer
* resilience
* pathology
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7673842
* tobacco smoking
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7417348
}}
}}
==NOX4==
==ALKBH8==


{{medline-entry
{{medline-entry
|title=Sestrin2 Attenuates Cellular Senescence by Inhibiting NADPH Oxidase 4 Expression.
|title=Loss of epitranscriptomic control of selenocysteine utilization engages senescence and mitochondrial reprogramming .
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/33227845
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31765888
|abstract=Sestrin2 (Sesn2) is involved in the maintenance of metabolic homeostasis and aging via modulation of the 5' AMP-activated protein kinase-mammalian target of rapamycin (AMPK-mTOR) pathway. Wild-type and Sesn2 knockout (KO) mice of the 129/SvJ background were maintained in a pathogen-free authorized facility under a 12-hour dark/light cycle at 20°C-22°C and 50%-60% humidity. Mouse embryonic fibroblasts (MEFs) were prepared from 13.5-day-old embryos derived from Sesn2-KO mice mated with each other. The MEFs from Sesn2-KO mice showed enlarged and flattened morphologies and senescence-associated β-galactosidase activity, accompanied by an elevated level of reactive oxygen species. These senescence phenotypes recovered following treatment with N-acetyl-cysteine. Notably, the mRNA levels of NADPH oxidase 4 ([[NOX4]]) and transforming growth factor (TGF)-β were markedly increased in Sesn2-KO MEFs. Treatment of Sesn2-KO MEFs with the NOX inhibitor diphenyleneiodonium and the TGF-β inhibitor SB431542 restored cell growth inhibited by Sesn2-KO. Sesn2 attenuates cellular senescence via suppression of TGF-β- and [[NOX4]]-induced reactive oxygen species generation and subsequent inhibition of AMPK.


|keywords=* NOX4
|mesh-terms=* AlkB Homolog 8, tRNA Methyltransferase
* Reactive oxygen species
* Animals
* Cells, Cultured
* Cellular Senescence
* Epigenesis, Genetic
* Gene Deletion
* Gene Expression Profiling
* Humans
* Mice
* Mitochondria
* Oxygen Consumption
* Selenocysteine
* Uncoupling Protein 2
|keywords=* Epitranscriptome
* Mitochondria
* Selenium
* Senescence
* Senescence
* Sestrin2
* Uncoupling protein
|full-text-url=https://sci-hub.do/10.4235/agmr.20.0051
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6904832
}}
}}
==NPR1==
==ALOX12==


{{medline-entry
{{medline-entry
|title=The [[NPR1]]-WRKY46-WRKY6 signaling cascade mediates probenazole/salicylic acid-elicited leaf senescence in Arabidopsis thaliana.
|title=Arachidonate 12-lipoxygenase and 12-hydroxyeicosatetraenoic acid contribute to stromal aging-induced progression of pancreatic cancer.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/33270345
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32265301
|abstract=Endogenous salicylic acid (SA) regulates leaf senescence, but the underlying mechanism remains largely unexplored. The exogenous application of SA to living plants is not efficient for inducing leaf senescence. By taking advantage of probenazole (PBZ)-induced biosynthesis of endogenous SA, we previously established a chemical inducible leaf senescence system that depends on SA biosynthesis and its core signaling receptor [[NPR1]] in Arabidopsis thaliana. Here, using this system, we identified WRKY46 and WRKY6 as key components of the transcriptional machinery downstream of [[NPR1]] signaling. Upon PBZ treatment, the wrky46 mutant exhibited significantly delayed leaf senescence. We demonstrate that [[NPR1]] is essential for PBZ/SA-induced WRKY46 activation, whereas WRKY46 in turn enhances [[NPR1]] expression. WRKY46 interacts with [[NPR1]] in the nucleus, binding to the W-box of the WRKY6 promoter to induce its expression in response to SA signaling. Dysfunction of WRKY6 abolished PBZ-induced leaf senescence, while overexpression of WRKY6 was sufficient to accelerate leaf senescence even under normal growth conditions, suggesting that WRKY6 may serve as an integration node of multiple leaf senescence signaling pathways. Taken together, these findings reveal that the [[NPR1]]-WRKY46-WRKY6 signaling cascade plays a critical role in PBZ/SA-mediated leaf senescence in Arabidopsis. This article is protected by copyright. All rights reserved.
 


|keywords=* Leaf senescence
|keywords=* aging
* NPR1
* arachidonic acid (AA) (ARA)
* Probenazole
* cancer biology
* Salicylic acid
* cell proliferation
* WRKY46
* fibroblast
* WRKY6
* pancreatic cancer
|full-text-url=https://sci-hub.do/10.1111/jipb.13044
* stromal cell
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7242692
}}
}}
==P2RY12==
==ALOX5==


{{medline-entry
{{medline-entry
|title=Potential caveats of putative microglia-specific markers for assessment of age-related cerebrovascular neuroinflammation.
|title=Functional Characterization of Knock-In Mice Expressing a 12/15-Lipoxygenating Alox5 Mutant Instead of the 5-Lipoxygenating Wild-Type Enzyme.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/33261619
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31642348
|abstract=The ability to distinguish resident microglia from infiltrating myeloid cells by flow cytometry-based surface phenotyping is an important technique for examining age-related neuroinflammation. The most commonly used surface markers for the identification of microglia include CD45 (low-intermediate expression), CD11b, Tmem119, and [[P2RY12]]. In this study, we examined changes in expression levels of these putative microglia markers in in vivo animal models of stroke, cerebral amyloid angiopathy (CAA), and aging as well as in an ex vivo LPS-induced inflammation model. We demonstrate that Tmem119 and [[P2RY12]] expression is evident within both CD45  and CD45  myeloid populations in models of stroke, CAA, and aging. Interestingly, LPS stimulation of FACS-sorted adult microglia suggested that these brain-resident myeloid cells can upregulate CD45 and downregulate Tmem119 and [[P2RY12]], making them indistinguishable from peripherally derived myeloid populations. Importantly, our findings show that these changes in the molecular signatures of microglia can occur without a contribution from the other brain-resident or peripherally sourced immune cells. We recommend future studies approach microglia identification by flow cytometry with caution, particularly in the absence of the use of a combination of markers validated for the specific neuroinflammation model of interest. The subpopulation of resident microglia residing within the "infiltrating myeloid" population, albeit small, may be functionally important in maintaining immune vigilance in the brain thus should not be overlooked in neuroimmunological studies.


|keywords=* Aging
|mesh-terms=* Aging
* Brain infiltrating myeloid cells
* Alanine
* CD45
* Animals
* Cerebral amyloid angiopathy
* Arachidonate 5-Lipoxygenase
* Microglia
* Asparagine
* Neuroinflammation
* Body Weight
* P2RY12
* Female
* Stroke
* Gene Knock-In Techniques
* Tmem119
* Leukotrienes
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7709276
* Linoleic Acid
* Male
* Mice
* Mutation
* PPAR gamma
* Phenylalanine
|keywords=* eicosanoids
* inflammation
* leukotrienes
* lipoxygenase
* resolvins
|full-text-url=https://sci-hub.do/10.1089/ars.2019.7751
}}
}}
==PDK1==
==AMH==


{{medline-entry
{{medline-entry
|title=Inhibition of 3-phosphoinositide-dependent protein kinase 1 ([[PDK1]]) can revert cellular senescence in human dermal fibroblasts.
|title=Beyond premature ovarian insufficiency: Staging reproductive aging in adolescent and young adult cancer survivors.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/33229519
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/33141175
|abstract=Cellular senescence is defined as a stable, persistent arrest of cell proliferation. Here, we examine whether senescent cells can lose senescence hallmarks and reenter a reversible state of cell-cycle arrest (quiescence). We constructed a molecular regulatory network of cellular senescence based on previous experimental evidence. To infer the regulatory logic of the network, we performed phosphoprotein array experiments with normal human dermal fibroblasts and used the data to optimize the regulatory relationships between molecules with an evolutionary algorithm. From ensemble analysis of network models, we identified 3-phosphoinositide-dependent protein kinase 1 ([[PDK1]]) as a promising target for inhibitors to convert the senescent state to the quiescent state. We showed that inhibition of [[PDK1]] in senescent human dermal fibroblasts eradicates senescence hallmarks and restores entry into the cell cycle by suppressing both nuclear factor κB and mTOR signaling, resulting in restored skin regeneration capacity. Our findings provide insight into a potential therapeutic strategy to treat age-related diseases associated with the accumulation of senescent cells.
 


|keywords=* PDK1
|keywords=* STRAW
* cellular senescence
* adolescent and young adult cancer
* network modeling
* menopausal transition
* skin aging
* premature ovarian insufficiency
* systems biology
* reproductive aging
|full-text-url=https://sci-hub.do/10.1073/pnas.1920338117
|full-text-url=https://sci-hub.do/10.1210/clinem/dgaa797
}}
}}
==PGC==
{{medline-entry
|title=Correlates and Timing of Reproductive Aging Transitions in a Global Cohort of Midlife Women With Human Immunodeficiency Virus: Insights From the REPRIEVE Trial.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32645159
 


|keywords=* Cardiometabolic Risk
* HIV
* Menopause
* Reproductive Aging
* Sex
* Women
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7347076
}}
{{medline-entry
{{medline-entry
|title=The Aging Stress Response and Its Implication for AMD Pathogenesis.
|title=Epigenetic clock measuring age acceleration via DNA methylation levels in blood is associated with decreased oocyte yield.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/33266495
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32285295
|abstract=Aging induces several stress response pathways to counterbalance detrimental changes associated with this process. These pathways include nutrient signaling, proteostasis, mitochondrial quality control and DNA damage response. At the cellular level, these pathways are controlled by evolutionarily conserved signaling molecules, such as 5'AMP-activated protein kinase (AMPK), mechanistic target of rapamycin (mTOR), insulin/insulin-like growth factor 1 (IGF-1) and sirtuins, including SIRT1. Peroxisome proliferation-activated receptor coactivator 1 alpha ([[PGC]]-1α), encoded by the [i]PPARGC1A[/i] gene, playing an important role in antioxidant defense and mitochondrial biogenesis, may interact with these molecules influencing lifespan and general fitness. Perturbation in the aging stress response may lead to aging-related disorders, including age-related macular degeneration (AMD), the main reason for vision loss in the elderly. This is supported by studies showing an important role of disturbances in mitochondrial metabolism, DDR and autophagy in AMD pathogenesis. In addition, disturbed expression of [[PGC]]-1α was shown to associate with AMD. Therefore, the aging stress response may be critical for AMD pathogenesis, and further studies are needed to precisely determine mechanisms underlying its role in AMD. These studies can include research on retinal cells produced from pluripotent stem cells obtained from AMD donors with the mutations, either native or engineered, in the critical genes for the aging stress response, including [i]AMPK[/i], [i]IGF1[/i], [i]MTOR[/i], [i]SIRT1[/i] and [i]PPARGC1A[/i].
 


|keywords=* AMD
|keywords=* Aging
* DNA damage response
* DNA methylation
* PGC-1α
* Epigenetic clock
* SIRT1
* Epigenetics
* age-related macular degeneration
* Infertility
* aging
* Methylome
* autophagy
* Ovarian aging
* insulin/IGF-1
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7244694
* mitochondrial quality control
* the aging stress response
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7700335
}}
}}
==PNN==
{{medline-entry
|title=Modeling Variation in the Reproductive Lifespan of Female Adolescent and Young Adult Cancer Survivors Using [[AMH]].
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32270202
 


|keywords=* AMH
* adolescent and young adult cancer
* functional principal components analysis
* ovarian reserve
* reproductive lifespan
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7329316
}}
{{medline-entry
{{medline-entry
|title=Hyaluronan degradation and release of a hyaluronan-aggrecan complex from perineuronal nets in the aged mouse brain.
|title=Improving Prediction of Age at Menopause Using Multiple Anti-Müllerian Hormone Measurements: the Tehran Lipid-Glucose Study.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/33253804
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32109280
|abstract=Perineuronal nets ([[PNN]]s) are insoluble aggregates of extracellular matrix molecules in the brain that consist of hyaluronan (HA) and chondroitin sulfate proteoglycans (CSPGs). [[PNN]]s promote the acquisition and storage of memories by stabilizing the formation of synapses in the adult brain. Although the deterioration of [[PNN]]s has been suggested to contribute to the age-dependent decline in brain function, the molecular mechanisms underlying age-related changes in [[PNN]]s remain unclear. The amount and solubility of [[PNN]] components were investigated by sequential extraction followed by a disaccharide analysis and immunoblotting. We examined the interaction between HA and aggrecan, a major HA-binding CSPG, by combining mass spectrometry and pull-down assays. The solubility and amount of HA increased in the brain with age. Among several CSPGs, the solubility of aggrecan was selectively elevated during aging. In contrast to alternations in biochemical properties, the expression of [[PNN]] components at the transcript level was not markedly changed by aging. The increased solubility of aggrecan was not due to the loss of HA-binding properties. Our results indicated that the degradation of high-molecular-mass HA induced the release of the HA-aggrecan complex from [[PNN]]s in the aged brain. The present study revealed a novel mechanism underlying the age-related deterioration of [[PNN]]s in the brain.
 


|keywords=* Brain aging
|keywords=* Tehran Lipid and Glucose Study (TLGS)
* Chondroitin sulfate proteoglycan
* anti-müllerian hormone (AMH)
* Extracellular matrix
* menopause
* Hyaluronan
* reproductive aging
* Perineuronal net
|full-text-url=https://sci-hub.do/10.1210/clinem/dgaa083
|full-text-url=https://sci-hub.do/10.1016/j.bbagen.2020.129804
}}
}}
==RNF10==
{{medline-entry
|title=Antimullerian Hormone and Impending Menopause in Late Reproductive Age: The Study of Women's Health Across the Nation.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31965189
 


|keywords=* aging
* female reproductive endocrinology
* gonadotropins
* inhibin/activin/follistatin/AMH
* menopause
* ovaries
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7067546
}}
{{medline-entry
{{medline-entry
|title=Reduced RING finger protein 10 expression in macrophages is associated with aging-related inflammation.
|title=Basal characterization and in vitro differentiation of putative stem cells derived from the adult mouse ovary.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/33249776
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31900800
|abstract=Age-associated decline of the immune system is referred to as immunosenescence. The E3 ligase RING finger 10 ([[RNF10]]) has long been associated with the innate immune response, but a potential role in immunosenescence has not previously been reported. In the present study, we identified that [[RNF10]] expression is lower in aged mouse macrophages than in young cells. After lipopolysaccharide (LPS) stimulation, [[RNF10]] expression remained at a basal low level in aged mouse cells, but declined sharply in young mouse cells. Knockdown of [[RNF10]] enhanced both the nuclear factor-κB (NF-κB) and interferon regulatory factor 3 (IRF3) signaling pathways and thus enhanced proinflammatory cytokines and type I interferons (IFN-I) in macrophages, promoting clearance of L. monocytigenes. These findings indicate that dysregulated expression of [[RNF10]] is associated with age-associated immune dysfunction, and [[RNF10]] may thus be a potential target for the treatment of age-related inflammatory diseases.
 
|keywords=* E3 ubiquitin ligase
* RNF10
* immunosenescence
* inflammation
* macrophages
|full-text-url=https://sci-hub.do/10.1002/2211-5463.13049
}}
==RPE==


|mesh-terms=* Aging
* Animals
* Anti-Mullerian Hormone
* Antigens, Ly
* Cell Differentiation
* Cell Shape
* Female
* Lewis X Antigen
* Membrane Proteins
* Mice, Inbred C57BL
* Ovary
* Stem Cells
|keywords=* BMP-4
* Multipotent
* Ovary
* Retinoic acid
* Stem cells
|full-text-url=https://sci-hub.do/10.1007/s11626-019-00411-x
}}
{{medline-entry
{{medline-entry
|title=Transcriptomic Profiling of Human Pluripotent Stem Cell-derived Retinal Pigment Epithelium over Time.
|title=Serum anti-Müllerian hormone concentration and follicle density throughout reproductive life and in different diseases-implications in fertility preservation.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/33307245
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31782794
|abstract=Human pluripotent stem cell (hPSC)-derived progenies are immature versions of cells, presenting a potential limitation to the accurate modelling of diseases associated with maturity or age. Hence, it is important to characterise how closely cells used in culture resemble their native counterparts. In order to select appropriate time points of retinal pigment epithelium ([[RPE]]) cultures that reflect native counterparts, we characterised the transcriptomic profiles of the hPSC-derived [[RPE]] cells from 1- and 12-month cultures. We differentiated the human embryonic stem cell line H9 into [[RPE]] cells, performed single-cell RNA-sequencing of a total of 16,576 cells to assess the molecular changes of the [[RPE]] cells across these two culture time points. Our results indicate the stability of the [[RPE]] transcriptomic signature, with no evidence of an epithelial-mesenchymal transition, and with the maturing populations of the [[RPE]] observed with time in culture. Assessment of Gene Ontology pathways revealed that as the cultures age, [[RPE]] cells upregulate expression of genes involved in metal binding and antioxidant functions. This might reflect an increased ability to handle oxidative stress as cells mature. Comparison with native human [[RPE]] data confirms a maturing transcriptional profile of [[RPE]] cells in culture. These results suggest that long-term in vitro culture of [[RPE]] cells allows the modelling of specific phenotypes observed in native mature tissues. Our work highlights the transcriptional landscape of hPSC-derived [[RPE]] cells as they age in culture, which provides a reference for native and patient samples to be benchmarked against.


|keywords=* Aging
|mesh-terms=* Adolescent
* Human embryonic stem cell
* Adult
* Human pluripotent stem cell
* Aging
* Retinal pigment epithelium
* Anti-Mullerian Hormone
* Single-cell RNA sequencing
* Child
|full-text-url=https://sci-hub.do/10.1016/j.gpb.2020.08.002
* Child, Preschool
* Female
* Fertility Preservation
* Humans
* Ovarian Follicle
* Retrospective Studies
* Young Adult
|keywords=* anti-Müllerian hormone
* cancer
* fertility preservation
* ovarian reserve
* ovarian tissue
* primary follicle
* primordial follicle
|full-text-url=https://sci-hub.do/10.1093/humrep/dez215
}}
}}
==SIRT1==
{{medline-entry
{{medline-entry
|title=Anthocyanins attenuate endothelial dysfunction through regulation of uncoupling of nitric oxide synthase in aged rats.
|title=Associations Between Anti-Mullerian Hormone and Cardiometabolic Health in Reproductive Age Women Are Explained by Body Mass Index.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/33274583
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31586179
|abstract=Endothelial dysfunction is one of the main age-related arterial phenotypes responsible for cardiovascular disease (CVD) in older adults. This endothelial dysfunction results from decreased bioavailability of nitric oxide (NO) arising downstream of endothelial oxidative stress. In this study, we investigated the protective effect of anthocyanins and the underlying mechanism in rat thoracic aorta and human vascular endothelial cells in aging models. In vitro, cyanidin-3-rutinoside (C-3-R) and cyanidin-3-glucoside (C-3-G) inhibited the d-galactose (d-gal)-induced senescence in human endothelial cells, as indicated by reduced senescence-associated-β-galactosidase activity, p21, and p16  . Anthocyanins blocked d-gal-induced reactive oxygen species (ROS) formation and NADPH oxidase activity. Anthocyanins reversed d-gal-mediated inhibition of endothelial nitric oxide synthase (eNOS) serine phosphorylation and [[SIRT1]] expression, recovering NO level in endothelial cells. Also, [[SIRT1]]-mediated eNOS deacetylation was shown to be involved in anthocyanin-enhanced eNOS activity. In vivo, anthocyanin-rich mulberry extract was administered to aging rats for 8 weeks. In vivo, mulberry extract alleviated endothelial senescence and oxidative stress in the aorta of aging rats. Consistently, mulberry extract also raised serum NO levels, increased phosphorylation of eNOS, increased [[SIRT1]] expression, and reduced nitrotyrosine in aortas. The eNOS acetylation was higher in the aging group and was restored by mulberry extract treatment. Similarly, [[SIRT1]] level associated with eNOS decreased in the aging group and was restored in aging plus mulberry group. These findings indicate that anthocyanins protect against endothelial senescence through enhanced NO bioavailability by regulating ROS formation and reducing eNOS uncoupling.


|keywords=* NO
|mesh-terms=* Adult
* SIRT1
* Anti-Mullerian Hormone
* anthocyanins
* Biomarkers
* eNOS deacetylation
* Body Mass Index
* senescence
* Cardiovascular Diseases
|full-text-url=https://sci-hub.do/10.1111/acel.13279
* Case-Control Studies
* Cross-Sectional Studies
* Female
* Follow-Up Studies
* Humans
* Incidence
* Infertility, Female
* Polycystic Ovary Syndrome
* Prognosis
* United States
|keywords=* anti-mullerian hormone (AMH)
* cardiometabolic health
* cardiovascular risk
* ovarian aging
* ovarian reserve markers
* reproductive aging
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7024739
}}
}}
{{medline-entry
{{medline-entry
|title=Sirtuins and Their Implications in Neurodegenerative Diseases from a Drug Discovery Perspective.
|title=Relationships between antral follicle count, blood serum concentration of anti-Müllerian hormone and fertility in mares.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/33280374
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31586925
|abstract=Sirtuins are class III histone deacetylase (HDAC) enzymes that target both histone and non-histone substrates. They are linked to different brain functions and the regulation of different isoforms of these enzymes is touted to be an emerging therapy for the treatment of neurodegenerative diseases (NDs), including Parkinson's disease (PD), Alzheimer's disease (AD), and amyotrophic lateral sclerosis (ALS). The level of sirtuins affects brain health as many sirtuin-regulated pathways are responsible for the progression of NDs. Certain sirtuins are also implicated in aging, which is a risk factor for many NDs. In addition to [[SIRT1]]-3, it has been suggested that the less studied sirtuins (SIRT4-7) also play critical roles in brain health. This review delineates the role of each sirtuin isoform in NDs from a disease centric perspective and provides an up-to-date overview of sirtuin modulators and their potential use as therapeutics in these diseases. Furthermore, the future perspectives for sirtuin modulator development and their therapeutic application in neurodegeneration are outlined in detail, hence providing a research direction for future studies.


|keywords=* Aging
|mesh-terms=* Aging
* neurodegenerative diseases
* Animals
* neuroprotective
* Anti-Mullerian Hormone
* sirtuin
* Female
* sirtuin activators
* Fertility
* sirtuin inhibitors
* Horses
|full-text-url=https://sci-hub.do/10.1021/acschemneuro.0c00696
* Ovarian Follicle
* Ovulation
|keywords=* AMH
* Anzahl Follikel
* Ovar
* Pferd
* Ultraschall
* compte folliculaire
* conta dei follicoli
* ecografia
* equine
* equini
* follicle count
* ovaia
* ovaire
* ovary
* reproductive status
* stato riproduttivo
* ultrasonography
* ­Reproduktionsstatus
* échographie
* équin
* état reproducteur
|full-text-url=https://sci-hub.do/10.17236/sat00225
}}
}}
==SIRT6==
==AMT==


{{medline-entry
{{medline-entry
|title=Association between [[SIRT6]] Methylation and Human Longevity in a Chinese Population.
|title=A multi-method comparison of autobiographical memory impairments amongst younger and older adults.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/33238266
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32162531
|abstract=Sirtuin 6 gene ([[SIRT6]]) is a longevity gene that is involved in a variety of metabolic pathways, but the relationship between [[SIRT6]] methylation and longevity has not been clarified. We conducted a case-control study on 129 residents with a family history of longevity (1 of parents, themselves, or siblings aged ≥90 years) and 86 individuals without a family history of exceptional longevity to identify the association. DNA pyrosequencing was performed to analyze the methylation status of [[SIRT6]] promoter CpG sites. qRT-PCR and ELISA were used to estimate the [[SIRT6]] messenger RNA (mRNA) levels and protein content. Six CpG sites (P1-P6) were identified as methylation variable positions in the [[SIRT6]] promoter region. At the P2 and P5 CpG sites, the methylation rates of the longevity group were lower than those of the control group (p < 0.001 and p = 0.009), which might be independent determinants of longevity. The mRNA and protein levels of [[SIRT6]] decreased in the control group (p < 0.0001 and p = 0.038). The mRNA level negatively correlated with the methylation rates at the P2 (rs = -0.173, p = 0.011) and P5 sites (rs = -0.207, p = 0.002). Furthermore, the protein content positively correlated with the methylation rate at the P5 site (rs = 0.136, p = 0.046) but showed no significant correlation with the methylation rate at the P2 site. The low level of [[SIRT6]] methylation may be a potential protective factor of Chinese longevity.
 


|keywords=* DNA Methylation
|keywords=* Depression
* Longevity
* aging
* Messenger RNA
* episodic memory
* SIRT6
* overgeneral
|full-text-url=https://sci-hub.do/10.1159/000508832
* specificity
|full-text-url=https://sci-hub.do/10.1080/13607863.2020.1729338
}}
}}
==SOD1==
==ANGPTL2==


{{medline-entry
{{medline-entry
|title=[[SOD1]], more than just an antioxidant.
|title=Circulating angiopoietin-like protein 2 levels and mortality risk in patients receiving maintenance hemodialysis: a prospective cohort study.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/33259795
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31840173
|abstract=During cellular respiration, radicals, such as superoxide, are produced, and in a large concentration, they may cause cell damage. To combat this threat, the cell employs the enzyme Cu/Zn Superoxide Dismutase ([[SOD1]]), which converts the radical superoxide into molecular oxygen and hydrogen peroxide, through redox reactions. Although this is its main function, recent studies have shown that the [[SOD1]] has other functions that deviates from its original one including activation of nuclear gene transcription or as an RNA binding protein. This comprehensive review looks at the most important aspects of human [[SOD1]] (h[[SOD1]]), including the structure, properties, and characteristics as well as transcriptional and post-translational modifications (PTM) that the enzyme can receive and their effects, and its many functions. We also discuss the strategies currently used to analyze it to better understand its participation in diseases linked to h[[SOD1]] including Amyotrophic Lateral Sclerosis (ALS), cancer, and Parkinson.


|keywords=* Aging
|mesh-terms=* Aged
* Cancer
* Angiopoietin-like Proteins
* Neurodegenerative diseases
* Biomarkers
* Post-translational modifications
* C-Reactive Protein
* Superoxide dismutase 1
* Disease Progression
|full-text-url=https://sci-hub.do/10.1016/j.abb.2020.108701
* Female
* Humans
* Kidney Diseases
* Male
* Middle Aged
* Prognosis
* Prospective Studies
* Renal Dialysis
* Risk Factors
* Survival Rate
|keywords=* aging
* angiopoietin-like protein (ANGPTL) 2
* chronic inflammation
* hemodialysis
* mortality risk
|full-text-url=https://sci-hub.do/10.1093/ndt/gfz236
}}
}}
==TNF==
==ANK3==


{{medline-entry
{{medline-entry
|title=Naringenin alleviates nonalcoholic steatohepatitis in middle-aged Apoe mice: role of SIRT1.
|title=Age-related atrophy of cortical thickness and genetic effect of [[ANK3]] gene in first episode MDD patients.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/33234364
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32911427
|abstract=Naringenin is naturally isolated from citrus fruits possessing many pharmacological activities. However, little is known about the effect of naringenin on nonalcoholic steatohepatitis (NASH) in the model of metabolic syndrome. The present study is aimed to investigate the effect of naringenin on NASH in 12-mo-old male ApoE  mice and its possible underlying mechanism. In vivo, 12-mo-old male ApoE  mice were administrated with naringenin by intragastric gavage for 12 weeks. At the end of experiment, the blood samples and liver tissues were collected. Metabolic parameters in serum, levels of triglyceride, cholesterol and hydroxyproline, activities of antioxidant enzymes, and content of inflammatory cytokines ([[TNF]]-α and IL-6) in liver were examined by corresponding assay kits. Pathological changes in liver were observed by hematoxylin-eosin, oil red O, masson's trichrome, picro-sirius red and senescence β-galactosidase staining. Dihydroethidium was used for detection of reactive oxygen species (ROS). In vitro, AML-12 cells were treated with oleic acid in the presence or absence of naringenin for 24 h. Transfection of SIRT1 siRNA was also conducted in vitro. Lipid accumulation, cellular ROS generation, malondialdehyde content, antioxidant enzyme activities and secretion levels of [[TNF]]-α and IL-6 were examined. Both in vivo and in vitro, gene expressions were detected by real-time PCR or western blot. Naringenin administration improved metabolic parameters, suppressed hepatic steatosis, regulated expression of genes involved in lipid metabolism (FASN, SCD1, PPARα and CPT1α), reduced hepatic fibrosis and cell senescence, inhibited hepatic inflammation as evidenced by the decreased macrophage recruitment and content of [[TNF]]-α and IL-6, and reduced hepatic oxidative stress by suppressing ROS generation and normalizing activities of antioxidant enzymes. Notably, naringenin administration increased hepatic SIRT1 protein expression and activity along with the increased deacetylation of liver kinase B1 (LKB1), PGC1α and NF-κB. In vitro study, the benefits of naringenin on lipid accumulation, oxidative stress and inflammation were diminished by SIRT1 siRNA transfection. These results indicate that naringenin administration may be a potential curative therapy for NASH treatment and the activation of hepatic SIRT1-mediated signaling cascades is involved in its beneficial effects.
 


|keywords=* AML-12 cells
|keywords=* ANK3
* Aging
* Aging
* ApoE(−/−) mice
* Cortical thickness
* Naringenin
* Major depressive disorder
* Nonalcoholic steatohepatitis
* Neuroimage
* SIRT1
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7490581
|full-text-url=https://sci-hub.do/10.1016/j.phymed.2020.153412
}}
==AOX1==
 
{{medline-entry
|title=N1-Methylnicotinamide: An Anti-Ovarian Aging Hormetin?
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32711159
 
 
|keywords=* AMPK
* MNAM
* Ovarian Aging
* ROS
|full-text-url=https://sci-hub.do/10.1016/j.arr.2020.101131
}}
}}
==TPH1==
==AP2B1==


{{medline-entry
{{medline-entry
|title=[i]Lactobacillus plantarum[/i] DR7 improved brain health in aging rats via the serotonin, inflammatory and apoptosis pathways.
|title=Circular RNA NF1-419 enhances autophagy to ameliorate senile dementia by binding Dynamin-1 and Adaptor protein 2 B1 in AD-like mice.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/33245015
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31860870
|abstract=Aging processes affect the brain in many ways, ranging from cellular to functional levels which lead to cognitive decline and increased oxidative stress. The aim of this study was to investigate the potentials of [i]Lactobacillus plantarum[/i] DR7 on brain health including cognitive and memory functions during aging and the impacts of high fat diet during a 12-week period. Male Sprague-Dawley rats were separated into six groups: (1) young animals on normal diet (ND, (2) young animals on a high fat diet (HFD), (3) aged animals on ND, (4) aged animals on HFD, (5) aged animals on HFD and [i]L. plantarum[/i] DR7 (10  cfu/day) and (6) aged animals receiving HFD and lovastatin. To induce ageing, all rats in group 3 to 6 were injected sub-cutaneously at 600 mg/kg/day of D-galactose daily. The administration of DR7 has reduced anxiety accompanied by enhanced memory during behavioural assessments in aged-HFD rats ([i]P[/i]<0.05). Hippocampal concentration of all three pro-inflammatory cytokines were increased during aging but reduced upon administration of both statin and DR7. Expressions of hippocampal neurotransmitters and apoptosis genes showed reduced expressions of indoleamine dioxygenase and P53 accompanied by increased expression of [[TPH1]] in aged- HFD rats administered with DR7, indicating potential effects of DR7 along the pathways of serotonin and oxidative senescence. This study provided an insight into potentials of [i]L. plantarum[/i] DR7 as a prospective dietary strategy to improve cognitive functions during aging. This study provided an insight into potentials of [i]L. plantarum[/i] DR7 as a prospective dietary strategy to improve cognitive functions during aging.


|keywords=* Lactobacillus spp.
|mesh-terms=* Adaptor Protein Complex beta Subunits
* aging
* Aging
* brain
* Alzheimer Disease
|full-text-url=https://sci-hub.do/10.3920/BM2019.0200
* Animals
* Astrocytes
* Autophagy
* Cellular Senescence
* Dynamin I
* Genes, Neurofibromatosis 1
* Mice
* RNA, Circular
* Rats
* Rats, Sprague-Dawley
|keywords=* aging
* astrocyte
* autophagy
* biological function
* circular RNA
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6949063
}}
}}
==TRIM27==
==APC==
 
{{medline-entry
|title=Differences between blacks and whites in well-being, beliefs, emotional states, behaviors and survival, 1978-2014.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32925952
 
|mesh-terms=* Adult
* African Americans
* Aged
* Behavior
* Cohort Studies
* Emotions
* European Continental Ancestry Group
* Female
* Hispanic Americans
* Humans
* Longevity
* Male
* Middle Aged
* Socioeconomic Factors
* Survival Analysis
* United States


|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7489510
}}
{{medline-entry
{{medline-entry
|title=[[TRIM27]] Functions as a Novel Oncogene in Non-Triple-Negative Breast Cancer by Blocking Cellular Senescence through p21 Ubiquitination.
|title=Wnt-induced, TRP53-mediated Cell Cycle Arrest of Precursors Underlies Interstitial Cell of Cajal Depletion During Aging.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/33251042
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32771388
|abstract=In the current study, we aimed to explore the correlation between [[TRIM27]] and breast cancer prognosis, as well as the functions of [[TRIM27]] in breast cancer and their underlying mechanisms. Bioinformatics analyses were used to examine the correlation between [[TRIM27]] and breast cancer prognosis. Moreover, [[TRIM27]] knockdown and overexpression in breast cancer cells were performed to investigate its functions in breast cancer. Tamoxifen (TAM) was applied to evaluate the influence of [[TRIM27]] on chemoresistance of breast cancer cells, while co-immunoprecipitation (coIP) was performed to identify the E3 ubiquitin ligase capability of [[TRIM27]]. High expression of [[TRIM27]] was found in non-triple-negative breast cancer (non-TNBC) tumor tissues and was positively correlated with the mortality of non-TNBC patients. Moreover, [[TRIM27]] could suppress non-TNBC cell apoptosis and senescence, promote cell viability and tumor growth, counteract the anti-cancer effects of TAM, and mediate ubiquitination of p21. In addition, EP300 could enhance the expression of [[TRIM27]] and its transcription promoter H3K27ac. [[TRIM27]], through ubiquitination of p21, might serve as a prognostic biomarker for non-TNBC prognosis. [[TRIM27]] functions as a novel oncogene in non-TNBC cellular processes, especially suppressing cell senescence and interfering with non-TNBC chemoresistance.
 


|keywords=* EP300
|keywords=* Compliance
* TRIM27
* Senescence
* breast cancer
* Stem Cell
* cell apoptosis
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7672319
* cell senescence
}}
* chemoresistance
{{medline-entry
* p21
|title=Burden of musculoskeletal disorders in Iran during 1990-2017: estimates from the Global Burden of Disease Study 2017.
* prognosis
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32651719
* transcription
 
* ubiquitination
|mesh-terms=* Female
* Global Burden of Disease
* Global Health
* Humans
* Iran
* Life Expectancy
* Male
* Musculoskeletal Diseases
* Quality-Adjusted Life Years
|keywords=* Burden
* DALY
* Decomposition
* Global burden of diseases
* Iran
* Musculoskeletal diseases
|full-text-url=https://sci-hub.do/10.1007/s11657-020-00767-8
}}
{{medline-entry
|title=Fall-related mortality trends in older Japanese adults aged ≥65 years: a nationwide observational study.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31831549
 
|mesh-terms=* Accidental Falls
* Aged
* Aged, 80 and over
* Female
* Geriatrics
* Health Policy
* Health Services Needs and Demand
* Humans
* Japan
* Male
* Mortality
* Public Health
|keywords=* adult intensive & critical care
* epidemiology
* geriatric medicine
* health & safety
* health policy
* public health
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6924807
}}
{{medline-entry
|title=Stroke Mortality Rates and Trends in Romania, 1994-2017.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31624036
 
|mesh-terms=* Adult
* Age Distribution
* Aged
* Aged, 80 and over
* Cause of Death
* Female
* Humans
* Life Expectancy
* Male
* Middle Aged
* Prognosis
* Registries
* Risk Assessment
* Risk Factors
* Romania
* Sex Distribution
* Stroke
* Time Factors
|keywords=* Mortality
* age-standardized mortality rates
* life expectancy
* stroke
|full-text-url=https://sci-hub.do/10.1016/j.jstrokecerebrovasdis.2019.104431
}}
{{medline-entry
|title=A new approach to quantifying the EEG during walking: Initial evidence of gait related potentials and their changes with aging and dual tasking.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31449852
 
|mesh-terms=* Accelerometry
* Adult
* Aged
* Aging
* Electroencephalography
* Evoked Potentials
* Exercise Test
* Female
* Gait
* Humans
* Male
* Middle Aged
* Multitasking Behavior
* Reaction Time
* Walking
|keywords=* Dual task
* EEG
* Gait cycle
* Gait related potentials (GRP)
|full-text-url=https://sci-hub.do/10.1016/j.exger.2019.110709
}}
==APOC3==
 
{{medline-entry
|title=Positional Obstructive Sleep Apnea Syndrome in Elderly Patients.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32050596
 
|mesh-terms=* Adult
* Aged
* Humans
* Middle Aged
* Polysomnography
* Posture
* Prospective Studies
* Sleep Apnea, Obstructive
* Supine Position
* Young Adult
|keywords=* aging effects
* obstructive sleep apnea
* polysomnography
* positional sleep apnea
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7042812
}}
==APOE==
 
{{medline-entry
|title=Polygenic risk score of longevity predicts longer survival across an age-continuum.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/33216869
 
 
|keywords=* centenarians
* cognitive health
* genetics
* healthy aging
* longevity
|full-text-url=https://sci-hub.do/10.1093/gerona/glaa289
}}
{{medline-entry
|title=Association Between [[APOE]] Alleles and Change of Neuropsychological Tests in the Long Life Family Study.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/33216038
 
 
|keywords=* APOE
* cognition
* longevity
* longitudinal studies
|full-text-url=https://sci-hub.do/10.3233/JAD-201113
}}
{{medline-entry
|title=The [[APOE]] gene cluster responds to air pollution factors in mice with coordinated expression of genes that differs by age in humans.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/33215813
 
 
|keywords=* Alzheimer's disease
* aging
* air pollution
* apolipoprotein E
* chromosome 19q13
|full-text-url=https://sci-hub.do/10.1002/alz.12230
}}
{{medline-entry
|title=Homozygosity in the [i][[APOE]][/i] 3 Polymorphism Is Associated With Less Depression and Higher Serum Low-Density Lipoprotein in Chinese Elderly Schizophrenics.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/33178131
 
 
|keywords=* APOE E3
* Chinese
* aging
* depressive symptom
* schizophrenia
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7593819
}}
{{medline-entry
|title=Effect of apolipoprotein E polymorphism on cognition and brain in the Cambridge Centre for Ageing and Neuroscience cohort.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/33088920
 
 
|keywords=* Cognition
* ageing
* apolipoprotein E
* brain
* lifespan
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7545750
}}
{{medline-entry
|title=Cardiovascular risk factors and [[APOE]]-ε4 status affect memory functioning in aging via changes to temporal stem diffusion.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/33070365
 
 
|keywords=* APOE
* BMI
* RRID:SCR_001398
* RRID:SCR_002403
* RRID:SCR_002823
* RRID:SCR_002865
* RRID:SCR_007037
* aging
* diffusion tensor imaging
* hypertension
* memory
* path modeling
|full-text-url=https://sci-hub.do/10.1002/jnr.24734
}}
{{medline-entry
|title=[[APOE]] [i]ε[/i]4 and resting-state functional connectivity in racially/ethnically diverse older adults.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32999914
 
 
|keywords=* APOE ε4 differences
* brain aging
* dementia
* neuroimaging
* racial/ethnic differences
* resting‐state functional connectivity
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7508460
}}
{{medline-entry
|title=Predictors of Olfactory Decline in Aging: A Longitudinal Population-Based Study.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32886741
 
 
|keywords=*  Cognitive aging
* Epidemiology
* Olfactory
* Olfactory impairment
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7662159
}}
{{medline-entry
|title=When Culture Influences Genes: Positive Age Beliefs Amplify the Cognitive-Aging Benefit of [[APOE]] ε2.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32835364
 
 
|keywords=*
          APOE
       
* Age beliefs
* Cognition
* Gene
* Health and Retirement Study
* Self-perceptions of aging
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7489069
}}
{{medline-entry
|title=Age and the association between apolipoprotein E genotype and Alzheimer disease: A cerebrospinal fluid biomarker-based case-control study.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32817639
 
|mesh-terms=* Adult
* Aged
* Aged, 80 and over
* Aging
* Alzheimer Disease
* Apolipoprotein E4
* Biomarkers
* Case-Control Studies
* Cohort Studies
* Female
* Genotype
* Humans
* Male
* Middle Aged
 
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7446786
}}
{{medline-entry
|title=Estimating the potential for dementia prevention through modifiable risk factors elimination in the real-world setting: a population-based study.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32767997
 
 
|keywords=* Aging
* Alzheimer’s disease
* Dementia
* Dementia prevention
* Modifiable risk factors
* Population attributable fraction
* Public health
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7414752
}}
{{medline-entry
|title=Machine learning-based estimation of cognitive performance using regional brain MRI markers: the Northern Manhattan Study.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32740887
 
 
|keywords=* Biomarkers
* Brain aging
* Cognitive aging
* Machine learning
|full-text-url=https://sci-hub.do/10.1007/s11682-020-00325-3
}}
{{medline-entry
|title=Effects of an [[APOE]] Promoter Polymorphism on Fronto-Parietal Functional Connectivity During Nondemented Aging.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32694990
 
 
|keywords=* APOE promoter
* aging
* brain connectome
* fronto-parietal network
* working memory
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7338603
}}
{{medline-entry
|title=The relationship of parental longevity with the aging brain-results from UK Biobank.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32671621
 
 
|keywords=* Aging
* Brain structure
* DTI
* MRI
* Neuroimaging
* Parental longevity
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7525531
}}
{{medline-entry
|title=Alzheimer's Patient Microglia Exhibit Enhanced Aging and Unique Transcriptional Activation.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32610143
 
 
|keywords=* Alzheimer’s disease
* aging
* microglia
* neurodegenerative diseases
* neuroinflammation
* transcriptomics
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7422733
}}
{{medline-entry
|title=Relationships Between Plasma Lipids Species, Gender, Risk Factors, and Alzheimer's Disease.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32474467
 
 
|keywords=* APOEɛ4
* Aging
* Alzheimer’s disease
* gender
* lipid
species
 
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7369125
}}
{{medline-entry
|title=Effects of sex, age, and apolipoprotein E genotype on hippocampal parenchymal fraction in cognitively normal older adults.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32416384
 
|mesh-terms=* Age Factors
* Aged
* Aged, 80 and over
* Apolipoproteins E
* Biomarkers
* Cognition
* Databases, Factual
* Female
* Genotype
* Hippocampus
* Humans
* Linear Models
* Male
* Middle Aged
* Neuroimaging
* Organ Size
* Parenchymal Tissue
* Reference Values
* Sex Factors
|keywords=* Alzheimer’s disease
* Apolipoprotein E ϵ4
* Atrophy
* Brain
* Healthy aging
* Hippocampal parenchymal fraction
* Hippocampal volumetric integrity
* Hippocampus
* MRI
* Mild cognitive impairment
* Neurodegeneration
* Sex
|full-text-url=https://sci-hub.do/10.1016/j.pscychresns.2020.111107
}}
{{medline-entry
|title=Cognitive Health of Nonagenarians in Southern Italy: A Descriptive Analysis from a Cross-Sectional, Home-Based Pilot Study of Exceptional Longevity (Cilento Initiative on Aging Outcomes Or CIAO).
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32380778
 
 
|keywords=* Cilento Region
* cognitive health
* lifestyle
* longevity
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7279440
}}
{{medline-entry
|title=Apolipoprotein E and Health in Older Men: The Concord Health and Ageing in Men Project.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32342099
 
 
|keywords=* Aging
* Alzheimer’s disease
* Apolipoprotein E
* Cognition
* Cognitive frailty
* Frailty
* Male
|full-text-url=https://sci-hub.do/10.1093/gerona/glaa105
}}
{{medline-entry
|title=CSF amyloid is a consistent predictor of white matter hyperintensities across the disease course from aging to Alzheimer's disease.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32305782
 
|mesh-terms=* Aged
* Aged, 80 and over
* Aging
* Alzheimer Disease
* Amyloid beta-Peptides
* Biomarkers
* Cerebrovascular Disorders
* Cognitive Dysfunction
* Female
* Humans
* Magnetic Resonance Imaging
* Male
* Peptide Fragments
* White Matter
* tau Proteins
|keywords=* Alzheimer's disease
* Amyloid
* Cerebrospinal fluid
* Tau
* Vascular disease
* White matter hyperintensities
|full-text-url=https://sci-hub.do/10.1016/j.neurobiolaging.2020.03.008
}}
{{medline-entry
|title=Association of Cardiovascular Risk Factors with Cerebral Perfusion in Whites and African Americans.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32310160
 
 
|keywords=* Aging
* Alzheimer’s disease
* blood pressure
* cerebrovascular circulation
* neuroimaging
* obesity
|full-text-url=https://sci-hub.do/10.3233/JAD-190360
}}
{{medline-entry
|title=Alzheimer's Risk Factors Age, [[APOE]] Genotype, and Sex Drive Distinct Molecular Pathways.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32199103
 
|mesh-terms=* Adaptor Proteins, Signal Transducing
* Age Factors
* Aging
* Alzheimer Disease
* Animals
* Apolipoprotein E2
* Apolipoprotein E3
* Apolipoprotein E4
* Apolipoproteins E
* Brain
* Female
* Gene Expression
* Gene Expression Profiling
* Gene Regulatory Networks
* Genotype
* Humans
* Male
* Membrane Glycoproteins
* Membrane Proteins
* Metabolome
* Mice
* Mice, Transgenic
* Protective Factors
* Receptors, Immunologic
* Risk Factors
* Serpins
* Sex Factors
* Unfolded Protein Response
|keywords=* APOE
* Alzheimer’s disease
* Serpina3
* age
* extracellular vesicles
* inflammation
* lipid metabolism
* metabolomics
* sex
* transcriptomics
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7388065
}}
{{medline-entry
|title=Less agreeable, better preserved? A PET amyloid and MRI study in a community-based cohort.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32169357
 
|mesh-terms=* Aged
* Aged, 80 and over
* Amyloidogenic Proteins
* Apolipoproteins E
* Brain
* Cognition
* Cohort Studies
* Female
* Follow-Up Studies
* Humans
* Magnetic Resonance Imaging
* Male
* Neuroimaging
* Organ Size
* Personality
* Positron-Emission Tomography
|keywords=* Amyloid load
* Cognitive aging
* Cohort studies
* Personality
* Structural MRI
|full-text-url=https://sci-hub.do/10.1016/j.neurobiolaging.2020.02.004
}}
{{medline-entry
|title=Physical Activity as Moderator of the Association Between [[APOE]] and Cognitive Decline in Older Adults: Results from Three Longitudinal Cohort Studies.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32110803
 
 
|keywords=* Gene–environment interaction
* InCHIANTI
* Longitudinal Aging Study Amsterdam
* Rotterdam Study
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7518558
}}
{{medline-entry
|title=Longitudinal Maintenance of Cognitive Health in Centenarians in the 100-plus Study.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32101309
 
|mesh-terms=* Aged, 80 and over
* Aging
* Apolipoprotein E4
* Cognition
* Female
* Humans
* Longitudinal Studies
* Male
* Mental Status and Dementia Tests
* Prospective Studies
 
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7137688
}}
{{medline-entry
|title=Interaction of [[APOE]], cerebral blood flow, and cortical thickness in the entorhinal cortex predicts memory decline.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32048144
 
 
|keywords=* APOE ε4
* Aging
* Cerebral blood flow
* Cognitive decline
* Cortical thickness
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7165062
}}
{{medline-entry
|title=Determinants of mesial temporal lobe volume loss in older individuals with preserved cognition: a longitudinal PET amyloid study.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32057528
 
|mesh-terms=* Aged
* Aged, 80 and over
* Aging
* Alleles
* Amyloidogenic Proteins
* Apolipoprotein E4
* Cognitive Reserve
* Female
* Follow-Up Studies
* Genotype
* Humans
* Longitudinal Studies
* Male
* Neuropsychological Tests
* Organ Size
* Positron-Emission Tomography
* Sex Factors
* Temporal Lobe
|keywords=* APOE
* Amyloid load
* Cognitive changes
* Mesial temporal lobe
* Normal aging
* Structural MRI
|full-text-url=https://sci-hub.do/10.1016/j.neurobiolaging.2019.12.002
}}
{{medline-entry
|title=Long-term exposure to ambient air pollution, [[APOE]]-ε4 status, and cognitive decline in a cohort of older adults in northern Manhattan.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31926436
 
|mesh-terms=* Aged
* Air Pollutants
* Air Pollution
* Apolipoprotein E4
* Apolipoproteins E
* Cognitive Dysfunction
* Female
* Genotype
* Humans
* Male
* Prospective Studies
* Washington
|keywords=* APOE-ε4 allele
* Aging
* Air pollution
* Cognitive decline
* Cognitive risk factors
* Epidemiology
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7024003
}}
{{medline-entry
|title=Evidence in support of chromosomal sex influencing plasma based metabolome vs [[APOE]] genotype influencing brain metabolome profile in humanized [[APOE]] male and female mice.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31917799
 
|mesh-terms=* Age of Onset
* Aging
* Alzheimer Disease
* Amyloid beta-Peptides
* Animals
* Apolipoprotein E4
* Apolipoproteins E
* Brain
* Disease Models, Animal
* Female
* Genotype
* Humans
* Magnetic Resonance Imaging
* Male
* Metabolome
* Mice
* Mice, Transgenic
* Sex Characteristics
* Sex Chromosomes
 
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6952084
}}
{{medline-entry
|title=[[APOE]] region molecular signatures of Alzheimer's disease across races/ethnicities.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31813627
 
|mesh-terms=* Alleles
* Alzheimer Disease
* Apolipoproteins E
* Continental Population Groups
* Haplotypes
* Heterozygote
* Homozygote
* Humans
* Linkage Disequilibrium
* Polymorphism, Single Nucleotide
* Risk Factors
|keywords=* APOE polymorphism
* Aging
* Alzheimer's disease
* Health span
* Life span
* Neurodegenerative disorders
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7064423
}}
{{medline-entry
|title=Varying Effects of [[APOE]] Alleles on Extreme Longevity in European Ethnicities.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31724059
 
|mesh-terms=* Aged, 80 and over
* Alleles
* Apolipoproteins E
* Ethnic Groups
* Europe
* European Continental Ancestry Group
* Female
* Humans
* Longevity
* Male
|keywords=* APOE
* Bioinformatics
* Human genetics
* Longevity
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7330482
}}
{{medline-entry
|title=Prospective Evaluation of Cognitive Health and Related Factors in Elderly at Risk for Developing Alzheimer's Dementia: A Longitudinal Cohort Study.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31686098
 
|mesh-terms=* Aged
* Aged, 80 and over
* Alzheimer Disease
* Anxiety
* Apolipoprotein E4
* Cognition
* Cognitive Dysfunction
* Cohort Studies
* Depression
* Efficiency
* Female
* Healthy Volunteers
* Humans
* Longitudinal Studies
* Male
* Mental Status and Dementia Tests
* Middle Aged
* Neuropsychological Tests
* Prospective Studies
* Risk Factors
* Sleep
* United Kingdom
* Work
|keywords=* Alzheimer Disease
* CHARIOT
* aging registry
* cognitive health
* pre-clinical
|full-text-url=https://sci-hub.do/10.14283/jpad.2019.31
}}
{{medline-entry
|title=Association of Cardiovascular and Alzheimer's Disease Risk Factors with Intracranial Arterial Blood Flow in Whites and African Americans.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31658057
 
|mesh-terms=* African Americans
* Aged
* Alzheimer Disease
* Biomarkers
* Blood Flow Velocity
* Cardiovascular Diseases
* Cerebrovascular Circulation
* European Continental Ancestry Group
* Female
* Humans
* Male
* Middle Aged
* Risk Factors
|keywords=* African Americans
* Alzheimer’s disease
* Apolipoprotein E4
* aging
* cerebrovascular circulation
* glucose
* metabolic syndrome
* neuroimaging
* risk factors
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7081660
}}
{{medline-entry
|title=Is Ongoing Anticholinergic Burden Associated With Greater Cognitive Decline and Dementia Severity in Mild to Moderate Alzheimer's Disease?
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31613323
 
 
|keywords=* Alzheimers
* Cognitive aging
* Drug related
* Medication
|full-text-url=https://sci-hub.do/10.1093/gerona/glz244
}}
{{medline-entry
|title=Multicenter Alzheimer's and Parkinson's disease immune biomarker verification study.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31630996
 
|mesh-terms=* Age Factors
* Aged
* Aged, 80 and over
* Alzheimer Disease
* Amyloid
* Biomarkers
* Cohort Studies
* Europe
* Female
* Humans
* Inflammation
* Male
* Middle Aged
* Parkinson Disease
* Sex Factors
* tau Proteins
|keywords=* Aging
* Alzheimer's disease
* Amyloid
* Biomarker
* Cerebrospinal fluid
* Inflammation
* Mild cognitive impairment
* Multicenter
* Parkinson's disease
* Tau
|full-text-url=https://sci-hub.do/10.1016/j.jalz.2019.07.018
}}
{{medline-entry
|title=Prospective Memory: Age related change is influenced by [[APOE]] genotype.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31578124
 
 
|keywords=*  APOE
* Alzheimer’s disease
* aging
* mid-adulthood
* prospective memory
|full-text-url=https://sci-hub.do/10.1080/13825585.2019.1671305
}}
{{medline-entry
|title=Education Moderates the Relation Between [[APOE]] ɛ4 and Memory in Nondemented Non-Hispanic Black Older Adults.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31594222
 
|mesh-terms=* Adult
* African Americans
* Aged
* Aged, 80 and over
* Aging
* Alzheimer Disease
* Apolipoprotein E4
* Cognitive Reserve
* Educational Status
* Executive Function
* Female
* Humans
* Male
* Memory
* Memory, Episodic
* Memory, Short-Term
* Middle Aged
* Neuropsychological Tests
* Sex Characteristics
|keywords=* APOE
* African American
* Alzheimer’s disease
* cognitive reserve
* educational attainment
* episodic memory
* genetic risk
* neuropsychological evaluation
|full-text-url=https://sci-hub.do/10.3233/JAD-190415
}}
{{medline-entry
|title=Apolipoprotein E ε4 allele effects on longitudinal cognitive trajectories are sex and age dependent.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31561966
 
|mesh-terms=* Age Factors
* Aged
* Alleles
* Apolipoprotein E4
* Cognition Disorders
* European Continental Ancestry Group
* Executive Function
* Female
* Humans
* Longitudinal Studies
* Male
* Memory
* Neuropsychological Tests
* Sex Factors
|keywords=* Aging
* Alzheimer's disease
* Apolipoprotein E ε4
* Cognitive decline
* Sex
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7561018
}}
{{medline-entry
|title=Interactive effect of age and [[APOE]]-ε4 allele load on white matter myelin content in cognitively normal middle-aged subjects.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31520917
 
|mesh-terms=* Age Factors
* Aged
* Aging
* Apolipoprotein E4
* Female
* Humans
* Magnetic Resonance Imaging
* Male
* Middle Aged
* Myelin Sheath
* White Matter
|keywords=* Aging
* Alzheimer
* Apolipoprotein E
* Cognitively normal subjects
* Myelination
* T1w/T2w ratio
* White matter integrity
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6742967
}}
{{medline-entry
|title=[[APOE]] modifies the interaction of entorhinal cerebral blood flow and cortical thickness on memory function in cognitively normal older adults.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31493534
 
|mesh-terms=* Aged
* Aged, 80 and over
* Apolipoproteins E
* Cerebral Cortex
* Cerebrovascular Circulation
* Entorhinal Cortex
* Female
* Genotype
* Humans
* Linear Models
* Male
* Memory
* Middle Aged
|keywords=* APOE ε4
* Aging
* Alzheimer’s disease
* Cerebral blood flow
* Cognitive decline
* Cortical thickness
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6819270
}}
{{medline-entry
|title=When time's arrow doesn't bend: [[APOE]]-ε4 influences episodic memory before old age.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31473197
 
|mesh-terms=* Adult
* Alleles
* Alzheimer Disease
* Apolipoprotein E4
* Cognition
* Cognitive Aging
* Female
* Genotype
* Humans
* Linear Models
* Male
* Memory
* Memory, Episodic
* Middle Aged
* Young Adult
|keywords=* Alzheimer's diseas
* Apolipoprotein E
* Cognition
* Episodic memory
* Semantic memory
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6817416
}}
{{medline-entry
|title=Cognitive-Motor Integration Performance Is Affected by Sex, [[APOE]] Status, and Family History of Dementia.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31424400
 
|mesh-terms=* Aged
* Apolipoproteins E
* Cognition
* Cognitive Dysfunction
* Cross-Sectional Studies
* Dementia
* Female
* Humans
* Male
* Medical History Taking
* Middle Aged
* Photic Stimulation
* Psychomotor Performance
* Sex Characteristics
* Surveys and Questionnaires
|keywords=* Aging
* alzheimer’s disease
* apolipoprotein E4
* dementia risk
* geriatric
assessment
* motor skills
* movement
* visuomotor integration
|full-text-url=https://sci-hub.do/10.3233/JAD-190403
}}
{{medline-entry
|title=Associations among amyloid status, age, and longitudinal regional brain atrophy in cognitively unimpaired older adults.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31437719
 
|mesh-terms=* Aged
* Aged, 80 and over
* Aging
* Amyloid beta-Peptides
* Atrophy
* Brain
* Cognition
* Cognitive Dysfunction
* Databases, Factual
* Female
* Humans
* Longitudinal Studies
* Male
* Middle Aged
|keywords=* Aging
* Alzheimer's disease
* Amyloid-β
* Brain atrophy
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7198229
}}
{{medline-entry
|title=Cognitive function and neuropathological outcomes: a forward-looking approach.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31435771
 
|mesh-terms=* Aged
* Aged, 80 and over
* Aging
* Alzheimer Disease
* Cognitive Dysfunction
* Female
* Humans
* Male
* Middle Aged
|keywords=* Alzheimer’s disease
* Cognition
* Multi-state model
* Neuropathology
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6851487
}}
{{medline-entry
|title=[[APOE]] gene-dependent BOLD responses to a breath-hold across the adult lifespan.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31408838
 
|mesh-terms=* Adult
* Aged
* Aging
* Apolipoprotein E3
* Apolipoprotein E4
* Apolipoproteins E
* Breath Holding
* Cerebrovascular Circulation
* Cross-Over Studies
* Double-Blind Method
* Female
* Genotype
* Hemodynamics
* Humans
* Longevity
* Magnetic Resonance Imaging
* Male
* Middle Aged
* Nitrates
|keywords=* Ageing
* Alzheimer's disease
* Apolipoprotein E
* BOLD fMRI
* Breath-hold
* Cerebrovascular reactivity
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6699560
}}
==APP==
 
{{medline-entry
|title=Pre-symptomatic Caspase-1 inhibitor delays cognitive decline in a mouse model of Alzheimer disease and aging.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32917871
 
|mesh-terms=* Aging
* Alzheimer Disease
* Amyloid beta-Peptides
* Animals
* Behavior, Animal
* Cognitive Dysfunction
* Cytokines
* Dipeptides
* Disease Models, Animal
* Encephalitis
* Female
* Humans
* Inflammation
* Male
* Memory Disorders
* Mice
* Mice, Inbred C57BL
* Mice, Transgenic
* Serpins
* Spatial Memory
* Viral Proteins
* para-Aminobenzoates
 
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7486940
}}
{{medline-entry
|title=Regorafenib Regulates AD Pathology, Neuroinflammation, and Dendritic Spinogenesis in Cells and a Mouse Model of AD.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32660121
 
 
|keywords=* aging
* amyloid beta
* dendritic spine
* neuroinflammation
* regorafenib
* tau
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7408082
}}
{{medline-entry
|title=An agnostic reevaluation of the amyloid cascade hypothesis of Alzheimer's disease pathogenesis: The role of [[APP]] homeostasis.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32588983
 
 
|keywords=* aging
* amyloid hypothesis
* amyloid precursor protein homeostasis
* late onset Alzheimer's disease
* young onset Alzheimer's disease
|full-text-url=https://sci-hub.do/10.1002/alz.12124
}}
{{medline-entry
|title=Transcriptomic profiling of microglia and astrocytes throughout aging.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32238175
 
 
|keywords=* Aging
* Alzheimer’s disease (AD)
* Astrocyte
* Microglia
* RNA-seq
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7115095
}}
{{medline-entry
|title=Platelets in Amyloidogenic Mice Are Activated and Invade the Brain.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32194368
 
 
|keywords=* Alzheimer’s disease
* aging
* astrocytes
* platelets
* vascular pathology
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7063083
}}
{{medline-entry
|title=CHIP modulates [[APP]]-induced autophagy-dependent pathological symptoms in Drosophila.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31777182
 
|mesh-terms=* Alzheimer Disease
* Amyloid beta-Protein Precursor
* Animals
* Aspartic Acid Endopeptidases
* Autophagy
* Brain
* Cognitive Dysfunction
* Disease Models, Animal
* Dopaminergic Neurons
* Down-Regulation
* Drosophila
* Drosophila Proteins
* Eye
* Learning Disabilities
* Locomotion
* Longevity
* Nuclear Proteins
* Presenilins
* RNA Interference
* Wings, Animal
|keywords=*
CHIP
 
* APP
* Alzheimer’s disease
* Aβ
* autophagy
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6996943
}}
{{medline-entry
|title=Studies on [[APP]] metabolism related to age-associated mitochondrial dysfunction in [[APP]]/PS1 transgenic mice.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31744937
 
|mesh-terms=* Adenosine Triphosphate
* Aging
* Alzheimer Disease
* Amyloid beta-Protein Precursor
* Animals
* Blood Platelets
* Disease Models, Animal
* Hippocampus
* Mice
* Mice, Inbred C57BL
* Mice, Transgenic
* Mitochondria
* Presenilin-1
|keywords=* APP/PS1 mice
* Amyloid-beta
* adenosine 5’-triphosphate
* mitochondria dysfunction
* platelets
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6914425
}}
{{medline-entry
|title=Intermittent Hypoxia-Hyperoxia Training Improves Cognitive Function and Decreases Circulating Biomarkers of Alzheimer's Disease in Patients with Mild Cognitive Impairment: A Pilot Study.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31671598
 
|mesh-terms=* Aged
* Alzheimer Disease
* Biomarkers
* Case-Control Studies
* Cognition
* Cognitive Dysfunction
* Female
* Humans
* Hyperoxia
* Hypoxia
* Male
* Middle Aged
* Pilot Projects
* Respiratory Therapy
* Treatment Outcome
|keywords=* Alzheimer’s disease
* adaptation
* aging
* amyloid beta
* biomarker
* cognitive function
* hyperoxia
* intermittent hypoxia
* platelets
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6862463
}}
{{medline-entry
|title=The Implication of Androgens in the Presence of Protein Kinase C to Repair Alzheimer’s Disease-Induced Cognitive Dysfunction
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31677609
 
|mesh-terms=* Adult
* Aged
* Aged, 80 and over
* Aging
* Alzheimer Disease
* Amyloid Precursor Protein Secretases
* Amyloid beta-Peptides
* Androgens
* Aspartic Acid Endopeptidases
* Cognition
* Cognitive Dysfunction
* Cyclic AMP Response Element-Binding Protein
* Female
* Hippocampus
* Humans
* Learning
* MAP Kinase Signaling System
* Male
* Middle Aged
* Neoplasm Proteins
* Phosphorylation
* Protein Kinase C
* Receptors for Activated C Kinase
* tau Proteins
|keywords=* Androgens
* Cognition
* Hippocampus
* Protein kinase C
* Spatial memory
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6984714
}}
{{medline-entry
|title=Modulation of Neural and Muscular Adaptation Processes During Resistance Training by Fish Protein Ingestions in Older Adults.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31596471
 
 
|keywords=* Aging
* Alaska pollack protein
* Motor unit identification
* Multichannel surface electromyography
* Nutritional supplementation
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7164534
}}
{{medline-entry
|title=Antipsychotic Polypharmacy in Older Adult Asian Patients With Schizophrenia: Research on Asian Psychotropic Prescription Pattern.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31480982
 
|mesh-terms=* Aged
* Aged, 80 and over
* Aging
* Antipsychotic Agents
* Asian Continental Ancestry Group
* Female
* Humans
* Male
* Middle Aged
* Polypharmacy
* Schizophrenia
|keywords=* Asian
* antipsychotic polypharmacy
* older adult patients
* schizophrenia
|full-text-url=https://sci-hub.do/10.1177/0891988719862636
}}
{{medline-entry
|title=A pleiotropic role for exosomes loaded with the amyloid β precursor protein carboxyl-terminal fragments in the brain of Down syndrome patients.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31479861
 
|mesh-terms=* Amyloid beta-Protein Precursor
* Brain
* Down Syndrome
* Exosomes
* Humans
|keywords=* APP
* APP-CTFs
* Aging
* Brain
* Down syndrome
* Exosomes
* Extracellular vesicles
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6960325
}}
==APPL1==
 
{{medline-entry
|title=Insulin and adipokine signaling and their cross-regulation in postmortem human brain.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31539648
 
|mesh-terms=* Adipokines
* Aging
* Brain
* Humans
* Insulin
* Leptin
* Postmortem Changes
* Signal Transduction
|keywords=* Adipokine
* Adiponectin receptors
* Alzheimer's disease–related dementias
* Leptin receptors
* Postmortem brain
* Type 2 diabetes
* insulin signaling
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6960343
}}
==AQP3==
 
{{medline-entry
|title=Transbuccal platform for delivery of lipogenic actives to facial skin: Because fat matters.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32592290
 
 
|keywords=* adipocytes
* aging
* cosmetics
* face
* fat pads
* integument
* subcutis
* wrinkles
|full-text-url=https://sci-hub.do/10.1002/term.3087
}}
==AR==
 
{{medline-entry
|title=Mechanisms of Androgen Receptor Agonist- and Antagonist-Mediated Cellular Senescence in Prostate Cancer.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32650419
 
 
|keywords=* PKB/Akt
* Src
* androgen receptor antagonist
* antiandrogen
* bipolar androgen therapy
* cellular senescence
* prostate cancer
* supraphysiological androgen levels
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7408918
}}
{{medline-entry
|title=Interleukin-23 Represses the Level of Cell Senescence Induced by the Androgen Receptor Antagonists Enzalutamide and Darolutamide in Castration-Resistant Prostate Cancer Cells.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32562083
 
 
|keywords=* Androgen receptor antagonists
* Cellular senescence
* Interleukin-23
* Prostate cancer spheroids
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7335377
}}
{{medline-entry
|title=A Landscape of Murine Long Non-Coding RNAs Reveals the Leading Transcriptome Alterations in Adipose Tissue during Aging.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32460027
 
 
|keywords=* adipocyte
* adipose tissue
* aging
* lncRNA
* long non-coding RNA
* non-coding RNA
* transcriptome
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7603645
}}
{{medline-entry
|title=Senolytic compounds control a distinct fate of androgen receptor agonist- and antagonist-induced cellular senescent LNCaP prostate cancer cells.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32351687
 
 
|keywords=* Akt inhibitor
* Antiandrogen
* Bcl-2 family inhibitor
* Bipolar androgen therapy
* Cellular senescence
* HSP90 inhibitor
* Prostate cancer
* Senolytic compounds
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7183592
}}
{{medline-entry
|title=Role of gut microbiota in sex- and diet-dependent metabolic disorders that lead to early mortality of androgen receptor-deficient male mice.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32017595
 
|mesh-terms=* Adipocytes
* Adipose Tissue
* Animals
* Anti-Bacterial Agents
* Diet
* Diet, High-Fat
* Feces
* Female
* Gastrointestinal Microbiome
* Lipid Metabolism
* Longevity
* Male
* Metabolic Diseases
* Mice
* Mice, Inbred C57BL
* Mice, Knockout
* Obesity
* Receptors, Androgen
* Sex Characteristics
|keywords=* androgen-insensitive syndrome
* longevity
* metabolic syndrome
* testosterone
* type 2 diabetes
|full-text-url=https://sci-hub.do/10.1152/ajpendo.00461.2019
}}
{{medline-entry
|title=A jaboticaba extract prevents prostatic damage associated with aging and high-fat diet intake.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32003372
 
|mesh-terms=* Aging
* Animals
* Cell Proliferation
* Diet, High-Fat
* Male
* Mice
* Myrtaceae
* Plant Extracts
* Prostate
 
|full-text-url=https://sci-hub.do/10.1039/c9fo02621e
}}
{{medline-entry
|title=Identifying blood-specific age-related DNA methylation markers on the Illumina MethylationEPIC® BeadChip.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31546163
 
|mesh-terms=* Adolescent
* Adult
* Aged
* Aged, 80 and over
* Aging
* Child
* Child, Preschool
* Cohort Studies
* CpG Islands
* DNA Methylation
* Forensic Genetics
* Genetic Markers
* Humans
* Infant
* Infant, Newborn
* Linear Models
* Middle Aged
* Oligonucleotide Array Sequence Analysis
* Young Adult
|keywords=* Age
* CpG sites
* DNA methylation
* Forensic age estimation
* Forensic epigenetics
* Illumina MethylationEPIC
|full-text-url=https://sci-hub.do/10.1016/j.forsciint.2019.109944
}}
==ARC==
 
{{medline-entry
|title=The Polymorphism rs2968 of [i]LSS[/i] Gene Confers Susceptibility to Age-Related Cataract.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32877255
 
|mesh-terms=* Aged
* Aging
* Alleles
* Cataract
* Female
* Gene Expression Regulation
* Genetic Association Studies
* Genetic Predisposition to Disease
* Genotype
* Haplotypes
* Humans
* Hydroxymethylglutaryl CoA Reductases
* Intramolecular Transferases
* Lens, Crystalline
* Male
* Middle Aged
* Polymorphism, Single Nucleotide
|keywords=* ARC
* HMGCR
* LSS
* SNPs
* lanosterol
|full-text-url=https://sci-hub.do/10.1089/dna.2020.5872
}}
{{medline-entry
|title=Decreased Anti-Müllerian hormone and Anti-Müllerian hormone receptor type 2 in hypothalami of old Japanese Black cows.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32554955
 
 
|keywords=* Müllerian inhibiting substance
* female reproductive senescence
* gonadotropin-releasing hormone neuron
* preoptic area
* ruminant
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7468072
}}
{{medline-entry
|title=Resveratrol delay the cataract formation against naphthalene-induced experimental cataract in the albino rats.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31746523
 
|mesh-terms=* Animals
* Cataract
* Dose-Response Relationship, Drug
* Male
* Naphthalenes
* Rats
* Rats, Sprague-Dawley
* Resveratrol
|keywords=* age-related cataracts
* aging
* oxidative stress
* resveratrol
|full-text-url=https://sci-hub.do/10.1002/jbt.22420
}}
==AREG==
 
{{medline-entry
|title=Targeting amphiregulin ([[AREG]]) derived from senescent stromal cells diminishes cancer resistance and averts programmed cell death 1 ligand (PD-L1)-mediated immunosuppression.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31493351
 
|mesh-terms=* Amphiregulin
* Animals
* Antineoplastic Agents
* B7-H1 Antigen
* Cells, Cultured
* Cellular Senescence
* Drug Resistance, Neoplasm
* Humans
* Mice
* Mice, Inbred NOD
* Mice, SCID
* Stromal Cells
* Tumor Microenvironment
|keywords=* aging
* amphiregulin
* cancer resistance
* clinical biomarker
* combinational treatment
* programmed cell death 1 ligand
* senescence-associated secretory phenotype
* stroma
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6826133
}}
==ARNT==
 
{{medline-entry
|title=Loss of [[ARNT]] in skeletal muscle limits muscle regeneration in aging.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/33064329
 
 
|keywords=* aging
* hypoxia signaling
* muscle regeneration
|full-text-url=https://sci-hub.do/10.1096/fj.202000761RR
}}
{{medline-entry
|title=[Arylhydrocarbon receptor nuclear translocator ([[ARNT]]) in human skin during aging.]
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32593246
 
|mesh-terms=* Adolescent
* Adult
* Aged
* Aged, 80 and over
* Aging
* Aryl Hydrocarbon Receptor Nuclear Translocator
* Child
* Child, Preschool
* Dermis
* Fetus
* Fibroblasts
* Humans
* Infant
* Infant, Newborn
* Skin
* Skin Aging
* Young Adult
|keywords=* ARNT
* PCNA
* aging
* fibroblasts
* skin
 
}}
{{medline-entry
|title=The E3 ubiquitin ligase STUB1 attenuates cell senescence by promoting the ubiquitination and degradation of the core circadian regulator BMAL1.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32041778
 
 
|keywords=* E3 ubiquitin ligase
* STIP1 homology and U-box-containing protein 1 (STUB1)
* brain and muscle ARNT-like 1 (BMAL1, ARNTL, MOP3)
* cell cycle regulation
* circadian clock
* hydrogen peroxide
* proteasome
* protein degradation
* senescence
* ubiquitylation (ubiquitination)
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7135990
}}
==ASB7==
 
{{medline-entry
|title=[[ASB7]] Is a Novel Regulator of Cytoskeletal Organization During Oocyte Maturation.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/33251222
 
 
|keywords=* ASBs
* maternal aging
* meiosis
* oocyte
* reproduction
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7674779
}}
==ASL==
 
{{medline-entry
|title=Increased blood-brain barrier permeability to water in the aging brain detected using noninvasive multi-TE [[ASL]] MRI.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32910547
 
 
|keywords=* aging
* aquaporin-4
* arterial spin labeling
* blood-brain barrier
* blood-brain interface
* water permeability
|full-text-url=https://sci-hub.do/10.1002/mrm.28496
}}
{{medline-entry
|title=Quantitative Cerebrovascular Reactivity in Normal Aging: Comparison Between Phase-Contrast and Arterial Spin Labeling MRI.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32849217
 
 
|keywords=* MRI
* aging
* arterial spin labeling
* cerebrovascular reactivity
* phase-contrast
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7411174
}}
{{medline-entry
|title=Correcting Task fMRI Signals for Variability in Baseline CBF Improves BOLD-Behavior Relationships: A Feasibility Study in an Aging Model.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32425745
 
 
|keywords=* BOLD deactivation
* aging
* cerebral blood flow
* domain-general
* language fMRI
* semantic fluency
* sensitization
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7205008
}}
==ASXL1==
 
{{medline-entry
|title=[[ASXL1]] mutation in clonal hematopoiesis.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31945396
 
|mesh-terms=* Aged
* Aging
* Animals
* Clonal Evolution
* Codon, Nonsense
* Hematologic Neoplasms
* Hematopoiesis
* Humans
* Myeloproliferative Disorders
* Neoplasm Proteins
* Repressor Proteins
 
|full-text-url=https://sci-hub.do/10.1016/j.exphem.2020.01.002
}}
==ATF4==
 
{{medline-entry
|title=Endoplasmic Reticulum Stress Mediates Vascular Smooth Muscle Cell Calcification via Increased Release of Grp78-Loaded Extracellular Vesicles.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/33297752
 
 
|keywords=* aging
* arteries
* endoplasmic reticulum
* vascular calcification
* warfarin
|full-text-url=https://sci-hub.do/10.1161/ATVBAHA.120.315506
}}
==ATF6==
 
{{medline-entry
|title=Cellular proteostasis decline in human senescence.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/33257563
 
 
|keywords=* UPR
* chaperones
* heat shock response
* protein homeostasis
* senescence
|full-text-url=https://sci-hub.do/10.1073/pnas.2018138117
}}
{{medline-entry
|title=Impact of endoplasmic reticulum stress on oocyte aging mechanisms.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32514562
 
 
|keywords=* ER stress
* GRP78
* PERK
* eIF2α
* endoplasmic reticulum
* mouse oocyte
* oocyte aging
* salubrinal
|full-text-url=https://sci-hub.do/10.1093/molehr/gaaa040
}}
{{medline-entry
|title=ER stress activates immunosuppressive network: implications for aging and Alzheimer's disease.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32279085
 
 
|keywords=* Ageing
* Immunometabolism
* Immunosenescence
* Immunosuppression
* Inflammaging
* Neurodegeneration
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7220864
}}
{{medline-entry
|title=Towards Age-Related Anti-Inflammatory Therapy: Klotho Suppresses Activation of ER and Golgi Stress Response in Senescent Monocytes.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31972978
 
 
|keywords=* ER stress response
* Golgi apparatus/complex stress response
* SASP
* immunosenescence
* klotho
* monocytes
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7072557
}}
==ATG3==
 
{{medline-entry
|title=Estrogen Signaling Induces Mitochondrial Dysfunction-Associated Autophagy and Senescence in Breast Cancer Cells.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32244623
 
 
|keywords=* Estrogen
* MCF-7
* MDA-MB-231
* autophagy
* mitochondria
* senescence
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7235898
}}
==ATG5==
 
{{medline-entry
|title=Autophagy and heat-shock response impair stress granule assembly during cellular senescence.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/33049246
 
 
|keywords=* Ageing
* Cellular senescence
* Molecular biology
* Oxidative stress
* Stress granules
|full-text-url=https://sci-hub.do/10.1016/j.mad.2020.111382
}}
==ATG7==
 
{{medline-entry
|title=Age-related impairment of autophagy in cervical motor neurons.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/33290859
 
 
|keywords=* Aging
* Autophagy
* Motor neuron
* Neuromuscular dysfunction
* Spinal cord
|full-text-url=https://sci-hub.do/10.1016/j.exger.2020.111193
}}
{{medline-entry
|title=Comprehensive Bioinformatics Identifies Key microRNA Players in [[ATG7]]-Deficient Lung Fibroblasts.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32527064
 
 
|keywords=* autophagy
* bioinformatics
* functional network analysis
* lung fibrosis
* miR
* proteomics
* senescence
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7312768
}}
{{medline-entry
|title=Regulation of autophagy by DNA G-quadruplexes.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32420812
 
 
|keywords=* G-quadruplex
* aging
* astrocytes
* autophagy
* neurodegeneration
* neurons
|full-text-url=https://sci-hub.do/10.1080/15548627.2020.1769991
}}
{{medline-entry
|title=[[ATG7]] is essential for secretion of iron from ameloblasts and normal growth of murine incisors during aging.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31880208
 
 
|keywords=* ATG7
* Aging
* ameloblast
* autophagy
* epithelium
* ferritin
* hyperplasia
* iron
* secretion
* tooth
|full-text-url=https://sci-hub.do/10.1080/15548627.2019.1709764
}}
{{medline-entry
|title=Enhancing Autophagy Diminishes Aberrant Ca  Homeostasis and Arrhythmogenesis in Aging Rabbit Hearts.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31636573
 
 
|keywords=* aging
* autophagy
* calcium
* cardiac physiology
* ryanodine receptor
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6787934
}}
==ATM==
 
{{medline-entry
|title=S[[ATM]]F Suppresses the Premature Senescence Phenotype of the [[ATM]] Loss-of-Function Mutant and Improves Its Fertility in [i]Arabidopsis[/i].
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/33143308
 
 
|keywords=* ATM
* DNA damage
* SATMF
* fertility
* leaf senescence
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7662627
}}
{{medline-entry
|title=[[ATM]] mediated-p53 signaling pathway forms a novel axis for senescence control.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32949791
 
 
|keywords=* ATM inhibition
* Metabolic reprogrammer
* Mitochondria
* P53
* Senescence alleviation
|full-text-url=https://sci-hub.do/10.1016/j.mito.2020.09.002
}}
{{medline-entry
|title=Non-canonical [[ATM]]/MRN activities temporally define the senescence secretory program.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32785991
 
 
|keywords=* DNA damage response
* MRN complex
* NF-κB
* chromatin
* senescence secretome
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7534619
}}
{{medline-entry
|title=[[ATM]] is a key driver of NF-κB-dependent DNA-damage-induced senescence, stem cell dysfunction and aging.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32201398
 
 
|keywords=* ATM
* DNA damage response
* NF-κB
* aging
* cellular senescence
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7138542
}}
{{medline-entry
|title=[[ATM]] suppresses leaf senescence triggered by DNA double-strand break through epigenetic control of senescence-associated genes in Arabidopsis.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32163596
 
 
|keywords=*
Arabidopsis thaliana
 
* ATM
* DNA repair
* double-strand breaks
* histone methylation
* leaf senescence
|full-text-url=https://sci-hub.do/10.1111/nph.16535
}}
{{medline-entry
|title=Glioblastoma Cells Do Not Affect Axitinib-Dependent Senescence of HUVECs in a Transwell Coculture Model.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32098270
 
|mesh-terms=* Ataxia Telangiectasia Mutated Proteins
* Axitinib
* Cell Line, Tumor
* Cellular Senescence
* Coculture Techniques
* Gene Expression Profiling
* Glioblastoma
* Human Umbilical Vein Endothelial Cells
* Humans
* Phosphorylation
|keywords=* Axitinib
* endothelial cells
* glioblastoma
* senescence
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7073100
}}
{{medline-entry
|title=Declining BRCA-Mediated DNA Repair in Sperm Aging and its Prevention by Sphingosine-1-Phosphate.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31916095
 
 
|keywords=* Aging
* DNA fragmentation
* Gene expression
* Sperm
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7065969
}}
{{medline-entry
|title=BRCA-related [[ATM]]-mediated DNA double-strand break repair and ovarian aging.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31822904
 
|mesh-terms=* Aging
* Animals
* Ataxia Telangiectasia
* BRCA1 Protein
* BRCA2 Protein
* DNA Breaks, Double-Stranded
* DNA Repair
* Female
* Fertility
* Fertility Preservation
* Humans
* Mice
* Oocytes
* Ovarian Follicle
* Ovarian Reserve
* Ovary
|keywords=*
          BRCA
       
*
          BRCA1/2
       
* DNA repair
* anti-Mullerian hormone
* chemotherapy
* mutations
* oocyte
* ovarian aging
* ovarian reserve
* ovarian response
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6935693
}}
{{medline-entry
|title=[[ATM]] Deficiency Accelerates DNA Damage, Telomere Erosion, and Premature T Cell Aging in HIV-Infected Individuals on Antiretroviral Therapy.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31781094
 
|mesh-terms=* Anti-Retroviral Agents
* Ataxia Telangiectasia Mutated Proteins
* Cellular Senescence
* DNA Damage
* HIV Infections
* Humans
* T-Lymphocytes
* Telomere
|keywords=* ATM
* DNA damage repair
* HIV
* T cell homeostasis
* apoptosis
* immune aging
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6856652
}}
{{medline-entry
|title=SMG1 heterozygosity exacerbates haematopoietic cancer development in Atm null mice by increasing persistent DNA damage and oxidative stress.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31565865
 
|mesh-terms=* Animals
* Ataxia Telangiectasia Mutated Proteins
* Carcinogenesis
* Cells, Cultured
* DNA Damage
* Embryo, Mammalian
* Fibroblasts
* Gamma Rays
* Hematologic Neoplasms
* Heterozygote
* Kaplan-Meier Estimate
* Longevity
* Lymphoma
* Mice, Inbred C57BL
* Mice, Knockout
* Oxidative Stress
* Protein-Serine-Threonine Kinases
|keywords=* DNA damage
* cancer
* inflammation
* lymphoma
* oxidative stress
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6850945
}}
{{medline-entry
|title=LncRNA RP11-670E13.6, interacted with hnRNPH, delays cellular senescence by sponging microRNA-663a in UVB damaged dermal fibroblasts.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31444317
 
|mesh-terms=* Cell Proliferation
* Cellular Senescence
* Fibroblasts
* Heterogeneous-Nuclear Ribonucleoprotein Group F-H
* Humans
* MicroRNAs
* RNA, Long Noncoding
* Skin
* Skin Aging
* Ultraviolet Rays
|keywords=* cellular senescence
* dermal fibroblast
* lncRNA
* microRNA
* ultraviolet B
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6738423
}}
{{medline-entry
|title=Tel1/[[ATM]] Signaling to the Checkpoint Contributes to Replicative Senescence in the Absence of Telomerase.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31391264
 
|mesh-terms=* Amino Acid Substitution
* Ataxia Telangiectasia Mutated Proteins
* Cell Cycle Checkpoints
* Cell Division
* Cellular Senescence
* DNA Damage
* DNA Replication
* DNA, Single-Stranded
* DNA-Binding Proteins
* Intracellular Signaling Peptides and Proteins
* Mutant Proteins
* Protein-Serine-Threonine Kinases
* Saccharomyces cerevisiae
* Saccharomyces cerevisiae Proteins
* Telomerase
* Telomere
* Telomere Shortening
|keywords=* Tel1
* checkpoint
* replicative senescence
* telomere
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6781906
}}
==ATP7A==
 
{{medline-entry
|title=Adipocyte-specific disruption of ATPase copper transporting α in mice accelerates lipoatrophy.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31396659
 
|mesh-terms=* 3T3-L1 Cells
* Adipocytes
* Adipose Tissue, White
* Aging
* Animals
* Body Weight
* Copper
* Copper-Transporting ATPases
* Diet, High-Fat
* Energy Metabolism
* Insulin Resistance
* Lipid Metabolism
* Lipodystrophy
* Lipolysis
* Mice
* Mice, Knockout
|keywords=* ATP7A
* Adipose tissues
* Copper
* Insulin resistance
* Lipoatrophy
|full-text-url=https://sci-hub.do/10.1007/s00125-019-4966-2
}}
==ATR==
 
{{medline-entry
|title=Bloodstain age estimation through infrared spectroscopy and Chemometric models.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/33077037
 
 
|keywords=* Aging
* Bloodstains
* Chemometric
* Forensic chemistry
* MLR
* PLSR
|full-text-url=https://sci-hub.do/10.1016/j.scijus.2020.07.004
}}
{{medline-entry
|title=Artificial Intelligence and fourier-transform infrared spectroscopy for evaluating water-mediated degradation of lubricant oils.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32887052
 
 
|keywords=* ANN
* Artificial neural networks
* FTIR
* LDA
* Linear discriminant analysis
* Lubricant oil aging
|full-text-url=https://sci-hub.do/10.1016/j.talanta.2020.121312
}}
{{medline-entry
|title=Senescence Induction by Combined Ionizing Radiation and DNA Damage Response Inhibitors in Head and Neck Squamous Cell Carcinoma Cells.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32883016
 
 
|keywords=* ATM
* ATR
* DNA damage response inhibitor
* DNAPK
* HNSCC
* homologous recombination
* ionizing radiation
* kinase inhibitor
* radiosensitivity
* senescence
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7563880
}}
{{medline-entry
|title=Kinetics of thermal degradation and lifetime study of poly(vinylidene fluoride) (PVDF) subjected to bioethanol fuel accelerated aging.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32775731
 
 
|keywords=* Activation energy
* Aging
* Bioethanol fuel
* Kinetics analysis
* Lifetime prediction
* Materials chemistry
* Materials science
* Poly(vinylidene fluoride)
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7398943
}}
{{medline-entry
|title=Supraphysiological protection from replication stress does not extend mammalian lifespan.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32253367
 
 
|keywords=* DNA damage
* aging
* cancer
* mouse models
* replication stress
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7185120
}}
{{medline-entry
|title=Assessing the Retest Reliability of Prefrontal EEG Markers of Brain Rhythm Slowing in the Eyes-Closed Resting State.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32253926
 
 
|keywords=* EEG
* EEG slowing
* brain aging
* dominant frequency
* prefrontal
|full-text-url=https://sci-hub.do/10.1177/1550059420914832
}}
{{medline-entry
|title=Effects of Hydrogen Peroxide and Sodium Hypochlorite Aging on Properties and Performance of Polyethersulfone Ultrafiltration Membrane.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31635217
 
|mesh-terms=* Humic Substances
* Hydrogen Peroxide
* Hydrophobic and Hydrophilic Interactions
* Membranes, Artificial
* Polymers
* Sodium Hypochlorite
* Sulfones
* Ultrafiltration
|keywords=* chemical cleaning
* hydrogen peroxide (H2O2)
* membrane aging
* polyethersulfone (PES) ultrafiltration (UF) membrane
* sodium hypochlorite (NaClO)
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6843545
}}
{{medline-entry
|title=NF-κB signaling in skin aging.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31634486
 
|mesh-terms=* Animals
* Cellular Senescence
* Humans
* NF-kappa B
* Phenotype
* Signal Transduction
* Skin Aging
* Skin Neoplasms
|keywords=* NF-κB
* Senescence-associated secretory phenotype
* Skin aging
|full-text-url=https://sci-hub.do/10.1016/j.mad.2019.111160
}}
{{medline-entry
|title=Development of a w/o emulsion using ionic liquid strategy for transdermal delivery of anti - aging component α - lipoic acid: Mechanism of different ionic liquids on skin retention and efficacy evaluation.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31634554
 
|mesh-terms=* Administration, Cutaneous
* Animals
* Emulsions
* Hydroxyproline
* Ionic Liquids
* Male
* Rats, Wistar
* Skin
* Skin Absorption
* Skin Aging
* Thioctic Acid
* Ultraviolet Rays
|keywords=* Anti – aging efficacy
* Ionic liquids
* Skin retention
* Solubility
* Α – lipoic acid
|full-text-url=https://sci-hub.do/10.1016/j.ejps.2019.105042
}}
{{medline-entry
|title=Effect of Nitrogen-Doped Graphene Oxide on the Aging Behavior of Nitrile-Butadiene Rubber.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31658636
 
 
|keywords=* aging resistance
* graphene oxide
* nitrile-butadiene rubber
* nitrogen-doped
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6835680
}}
==AVP==
 
{{medline-entry
|title=Plasma oxytocin and vasopressin levels in young and older men and women: Functional relationships with attachment and cognition.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31606581
 
|mesh-terms=* Adolescent
* Adult
* Age Factors
* Aged
* Aged, 80 and over
* Aging
* Anxiety
* Avoidance Learning
* Cognition
* Cohort Studies
* Female
* Humans
* Male
* Middle Aged
* Object Attachment
* Oxytocin
* Sex Factors
* Vasopressins
* Young Adult
|keywords=* Age
* Attachment anxiety
* Oxytocin
* Processing speed
* Sex
* Vasopressin
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6943921
}}
==B4GALT1==
 
{{medline-entry
|title=Expression of β-1,4-galactosyltransferases during Aging in Caenorhabditis elegans.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/33171474
 
 
|keywords=* Biomarker
* Glycosylation
* Lifespan regulation
* bre-4
* sqv-3
|full-text-url=https://sci-hub.do/10.1159/000510722
}}
==BACE1==
 
{{medline-entry
|title=Electric Stimulation of Neurogenesis Improves Behavioral Recovery After Focal Ischemia in Aged Rats.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32742258
 
 
|keywords=* aging
* behavior
* electrical stimulation
* neurogenesis
* rats
* stroke
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7365235
}}
{{medline-entry
|title=Disruption of synaptic expression pattern and age-related DNA oxidation in a neuronal model of lead-induced toxicity.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32058320
 
 
|keywords=* Aging mice
* Brain-derived neurotrophic factor precursor
* Latent expression pattern
* Lead
* Pubertal exposure
* Synaptic deficits
* Tau phosphorylation
|full-text-url=https://sci-hub.do/10.1016/j.etap.2020.103350
}}
==BAD==
 
{{medline-entry
|title=I  imidazoline receptor modulation protects aged SAMP8 mice against cognitive decline by suppressing the calcineurin pathway.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/33128688
 
 
|keywords=* Aging
* Alzheimer’s disease
* Behavior
* I2 imidazoline receptors
* NFAT
* Neuroinflammation
* Neuroprotection
|full-text-url=https://sci-hub.do/10.1007/s11357-020-00281-2
}}
==BAK1==
 
{{medline-entry
|title=Developmental Attenuation of Neuronal Apoptosis by Neural-Specific Splicing of Bak1 Microexon.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32710818
 
|mesh-terms=* Animals
* Apoptosis
* Brain
* Cell Line, Tumor
* Cells, Cultured
* Female
* Heterogeneous-Nuclear Ribonucleoproteins
* Male
* Mice
* Mice, Inbred C57BL
* Mutation
* Neural Stem Cells
* Neurogenesis
* Nonsense Mediated mRNA Decay
* Polypyrimidine Tract-Binding Protein
* RNA Splicing
* bcl-2 Homologous Antagonist-Killer Protein
|keywords=* AS-NMD
* BAK
* BCL2 family proteins
* NMD
* PTB
* PTBP
* PTBP2
* UPF2
* alternative splicing
* cell death
* neural development
* neurogenesis
* neuronal lifespan
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7529960
}}
==BANF1==
 
{{medline-entry
|title=An additional case of Néstor-Guillermo progeria syndrome diagnosed in early childhood.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32783369
 
 
|keywords=* BANF1
* Néstor-Guillermo progeria syndrome
* premature aging
* progeria
* whole exome sequencing
|full-text-url=https://sci-hub.do/10.1002/ajmg.a.61777
}}
==BATF==
 
{{medline-entry
|title=LncRNA-ES3 inhibition by Bhlhe40 is involved in high glucose-induced calcification/senescence of vascular smooth muscle cells.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32483833
 
 
|keywords=* Bhlhe40
* VSMC calcification/senescence
* diabetes
* lncRNA-ES3
* microRNA
* vascular aging
|full-text-url=https://sci-hub.do/10.1111/nyas.14381
}}
==BAX==
 
{{medline-entry
|title=Clearance of therapy-induced senescent tumor cells by the senolytic ABT-263 via interference with BCL-X  -[[BAX]] interaction.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32652830
 
 
|keywords=* ABT-263
* BCL-XL
* chemotherapy
* radiation
* senescence
* senolytic
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7530780
}}
{{medline-entry
|title=CREB Signaling Mediates Dose-Dependent Radiation Response in the Murine Hippocampus Two Years after Total Body Exposure.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31657930
 
 
|keywords=* CREB signaling
* aging
* brain
* hippocampus
* ionizing radiation
* label-free proteomics
|full-text-url=https://sci-hub.do/10.1021/acs.jproteome.9b00552
}}
==BAZ2B==
 
{{medline-entry
|title=Two conserved epigenetic regulators prevent healthy ageing.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32103178
 
|mesh-terms=* Aging
* Animals
* Caenorhabditis elegans
* Caenorhabditis elegans Proteins
* Cognition
* Cognitive Dysfunction
* Epigenesis, Genetic
* Healthy Aging
* Histone-Lysine N-Methyltransferase
* Histones
* Humans
* Longevity
* Lysine
* Male
* Memory
* Methylation
* Mice
* Mitochondria
* Neurons
* Proteins
* RNA Interference
* Spatial Learning
* Transcription Factors, General
 
|full-text-url=https://sci-hub.do/10.1038/s41586-020-2037-y
}}
==BCL6==
 
{{medline-entry
|title=Ecto-NTPDase CD39 is a negative checkpoint that inhibits follicular helper cell generation.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32452837
 
 
|keywords=* Adaptive immunity
* Aging
* Cellular senescence
* T cells
* Vaccines
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7324201
}}
==BCR==
 
{{medline-entry
|title=The presence of CLL-associated stereotypic B cell receptors in the normal [[BCR]] repertoire from healthy individuals increases with age.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31485252
 
 
|keywords=* Aging
* B-lymphocyte
* BCR repertoire
* CLL
* Stereotypic BCR
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6714092
}}
==BDNF==
 
{{medline-entry
|title=Influence of [i][[BDNF]][/i] Genetic Polymorphisms in the Pathophysiology of Aging-related Diseases.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/33269104
 
 
|keywords=* Aging
* BDNF gene
* aging-related diseases
* polymorphism
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7673859
}}
{{medline-entry
|title=Moderators of the Impact of (Poly)Phenols Interventions on Psychomotor Functions and [[BDNF]]: Insights from Subgroup Analysis and Meta-Regression.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32961777
 
 
|keywords=* aging
* antioxidant
* brain functions
* brain plasticity
* cognition
* psychomotor functions
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7551086
}}
{{medline-entry
|title=Astroglia-Derived [[BDNF]] and MSK-1 Mediate Experience- and Diet-Dependent Synaptic Plasticity.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32708382
 
 
|keywords=* AMPA receptors
* Arc/Arg3.1
* GABA receptors
* TrkB receptors
* aging
* calcium signalling
* dendritic spines
* diet
* enriched environment
* glia-neuron interactions
* ion conductance microscopy
* synaptic scaling
* synaptic strength
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7407492
}}
{{medline-entry
|title=[[BDNF]] reverses aging-related microglial activation.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32664974
 
 
|keywords=* Aging
* BDNF
* CREB
* Microglial activation
* NF-кB
* TrkB
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7362451
}}
{{medline-entry
|title=High Supervised Resistance Training in Elderly Women: The Role of Supervision Ratio.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32509119
 
 
|keywords=* Aging
* exercise
* functional capacity
* muscle strength
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7241618
}}
{{medline-entry
|title=Metformin regulates astrocyte reactivity in Parkinson's disease and normal aging.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32497590
 
 
|keywords=* Aging
* Dorsal striatum
* Metformin
* Parkinson's disease
* Reactive astrocyte
|full-text-url=https://sci-hub.do/10.1016/j.neuropharm.2020.108173
}}
{{medline-entry
|title=Aging-Induced Brain-Derived Neurotrophic Factor in Adipocyte Progenitors Contributes to Adipose Tissue Dysfunction.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32489703
 
 
|keywords=* BDNF
* adipocyte progenitors
* adipose tissue
* aging
* sympathetic innervation
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7220283
}}
{{medline-entry
|title=The Role of [[BDNF]] on Aging-Modulation Markers.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32397504
 
 
|keywords=* BBB
* astrocytes
* brain aging
* in vivo model
* low dose BDNF
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7287884
}}
{{medline-entry
|title=Spermidine and spermine delay brain aging by inducing autophagy in SAMP8 mice.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32268299
 
 
|keywords=* aging
* autophagy
* mitochondrial dysfunction
* polyamine
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7185103
}}
{{medline-entry
|title=Microglia senescence occurs in both substantia nigra and ventral tegmental area.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32275335
 
 
|keywords=* Parkinson's disease
* aging-dependent neurodegeneration
* dopamine neurons
* microglia complexity
* stereological analyses
* tyrosine hydroxylase; microglia senescence
|full-text-url=https://sci-hub.do/10.1002/glia.23834
}}
{{medline-entry
|title=Towards an understanding of the physical activity-[[BDNF]]-cognition triumvirate: A review of associations and dosage.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32171785
 
|mesh-terms=* Aging
* Brain-Derived Neurotrophic Factor
* Cognition
* Exercise
* Healthy Aging
* Humans
|keywords=* Ageing
* BDNF
* Brain
* Physical activity
|full-text-url=https://sci-hub.do/10.1016/j.arr.2020.101044
}}
{{medline-entry
|title=Impact of [[BDNF]] and sex on maintaining intact memory function in early midlife.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31948671
 
|mesh-terms=* Brain
* Brain-Derived Neurotrophic Factor
* Cognition
* Female
* Humans
* Magnetic Resonance Imaging
* Male
* Memory
* Memory, Short-Term
* Menopause
* Middle Aged
* Neuroprotective Agents
* Neuropsychological Tests
* Reproduction
* Sex Characteristics
|keywords=* Aging
* BDNF
* Hormones
* Memory
* Menopause
* Sex differences
|full-text-url=https://sci-hub.do/10.1016/j.neurobiolaging.2019.12.014
}}
{{medline-entry
|title=Testosterone replacement causes dose-dependent improvements in spatial memory among aged male rats.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31901624
 
 
|keywords=* Aging
* BDNF
* Object location memory
* Radial arm maze
* Spatial memory
* Testosterone
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7080566
}}
{{medline-entry
|title=The effects of aerobic exercise intensity on memory in older adults.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31665610
 
 
|keywords=* BDNF
* activité physique
* aging
* cognition
* entraînement par intervalles de haute intensité
* executive functions
* exercice
* exercise
* fonctions exécutives
* high-intensity interval training
* memory
* mémoire
* physical activity
* vieillissement
|full-text-url=https://sci-hub.do/10.1139/apnm-2019-0495
}}
{{medline-entry
|title=Protective effects of vitamin D on neurophysiologic alterations in brain aging: role of brain-derived neurotrophic factor ([[BDNF]]).
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31524100
 
 
|keywords=* BDNF
* Brain aging
* neurophysiologic alterations
* neuroprotection
* vitamin D supplementation
|full-text-url=https://sci-hub.do/10.1080/1028415X.2019.1665854
}}
{{medline-entry
|title=Differential Effects of Physical Exercise, Cognitive Training, and Mindfulness Practice on Serum [[BDNF]] Levels in Healthy Older Adults: A Randomized Controlled Intervention Study.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31498125
 
|mesh-terms=* Aged
* Brain-Derived Neurotrophic Factor
* Cognition
* Correlation of Data
* Exercise
* Female
* Healthy Aging
* Healthy Lifestyle
* Humans
* Learning
* Male
* Mindfulness
* Neuropsychological Tests
* Outcome Assessment, Health Care
|keywords=* Aging
* brain-derived neurotrophic factor
* cognitive training
* mindfulness
* physical exercise
|full-text-url=https://sci-hub.do/10.3233/JAD-190756
}}
{{medline-entry
|title=Dietary Supplementation with Fish Oil or Conjugated Linoleic Acid Relieves Depression Markers in Mice by Modulation of the Nrf2 Pathway.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31398773
 
|mesh-terms=* Aging
* Animals
* Antidepressive Agents
* Autoimmunity
* Biomarkers
* Brain
* Brain-Derived Neurotrophic Factor
* Depression
* Dietary Supplements
* Docosahexaenoic Acids
* Fatty Acid Elongases
* Fatty Acids
* Fish Oils
* Inflammation
* Linoleic Acids, Conjugated
* Liver
* Male
* Mice, Inbred MRL lpr
* NF-E2-Related Factor 2
* Oxidative Stress
* Stearoyl-CoA Desaturase
* Tumor Necrosis Factor-alpha
|keywords=* brain derived neurotrophic factor
* brain fatty acid profile
* conjugated linoleic acid
* depression
* fish oil
* nuclear erythroid related factor-2
|full-text-url=https://sci-hub.do/10.1002/mnfr.201900243
}}
==BGN==
 
{{medline-entry
|title=Alterations of local functional connectivity in lifespan: A resting-state fMRI study.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32462815
 
 
|keywords=* four-dimensional spatial-temporal consistency of local neural activity
* lifespan
* local functional connectivity
* local functional connectivity density
* resting-state fMRI
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7375100
}}
==BHLHE40==
 
{{medline-entry
|title=Thyroid hormone induces cellular senescence in prostate cancer cells through induction of DEC1.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32360904
 
|mesh-terms=* Basic Helix-Loop-Helix Transcription Factors
* Cell Line, Tumor
* Cell Proliferation
* Cellular Senescence
* Cyclin-Dependent Kinase Inhibitor p15
* Homeodomain Proteins
* Humans
* Male
* Prostatic Neoplasms
* Thyroid Hormones
|keywords=* BHLHE40
* Cellular senescence
* DEC1
* Prostate cancer
* Thyroid hormone
|full-text-url=https://sci-hub.do/10.1016/j.jsbmb.2020.105689
}}
==BLM==
 
{{medline-entry
|title=[Olmesartan inhibits age-associated migration and invasion of human aortic vascular smooth muscle cells by upregulating miR-3133 axis].
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32895132
 
|mesh-terms=* Cell Movement
* Cell Proliferation
* Cells, Cultured
* Humans
* Imidazoles
* Matrix Metalloproteinase 2
* MicroRNAs
* Muscle, Smooth, Vascular
* Myocytes, Smooth Muscle
* Tetrazoles
|keywords=* aging
* invasion
* microRNA
* migration
* olmesartan
* vascular smooth muscle cells
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7225100
}}
==BMI1==
 
{{medline-entry
|title=Senescence Induced by [[BMI1]] Inhibition Is a Therapeutic Vulnerability in H3K27M-Mutant DIPG.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/33086074
 
 
|keywords=* BH3 mimetics
* BMI1
* DIPG
* H3K27M mutant
* H3WT
* PTC 028
* RNAi screen
* SASP
* senescence
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7574900
}}
==BMP2==
 
{{medline-entry
|title=Interleukin-1β-Induced Senescence Promotes Osteoblastic Transition of Vascular Smooth Muscle Cells.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32126555
 
|mesh-terms=* Adult
* Aged
* Aged, 80 and over
* Female
* Humans
* Interleukin-1beta
* Male
* Middle Aged
* Muscle, Smooth, Vascular
* Osteoblasts
|keywords=* Interleukin-1β
* Osteoblastic transition
* Senescence
* Vascular calcification
|full-text-url=https://sci-hub.do/10.1159/000504298
}}
==BMP4==
 
{{medline-entry
|title=Direct reprogramming of human smooth muscle and vascular endothelial cells reveals defects associated with aging and Hutchinson-Gilford progeria syndrome.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32896271
 
 
|keywords=* aging
* direct reprogramming
* endothelial cell
* human
* hutchinson-gilford progeria syndrome
* medicine
* mouse
* smooth muscle cell
* vascular barrier
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7478891
}}
==BMP7==
 
{{medline-entry
|title=Downregulation of miR-542-3p promotes osteogenic transition of vascular smooth muscle cells in the aging rat by targeting [[BMP7]].
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31829291
 
|mesh-terms=* Aging
* Animals
* Base Sequence
* Bone Morphogenetic Protein 7
* Down-Regulation
* Glycerophosphates
* MicroRNAs
* Models, Biological
* Muscle, Smooth, Vascular
* Myocytes, Smooth Muscle
* Osteogenesis
* Rats
|keywords=* Aging
* Mir-542-3p
* Osteogenic differentiation
* Vascular smooth muscle cells
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6907335
}}
==BOC==
 
{{medline-entry
|title=Protein Requirements of Elderly Chinese Adults Are Higher than Current Recommendations.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32140711
 
|mesh-terms=* Aged
* Aging
* Amino Acids
* Body Weight
* China
* Dietary Proteins
* Energy Intake
* Energy Metabolism
* Female
* Humans
* Male
* Nutritional Requirements
* Oxidation-Reduction
* Phenylalanine
* Recommended Dietary Allowances
* Tyrosine
|keywords=* indicator amino acid oxidation
* older adults
* phenylalanine oxidation
* protein requirement
* stable isotope
|full-text-url=https://sci-hub.do/10.1093/jn/nxaa031
}}
==BPI==
 
{{medline-entry
|title=High TARC plasma levels confer protection to long living individuals by inducing M2 profile.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/33002742
 
 
|keywords=* FACS
* Longevity
* M2 macrophages
* Plasma profile
* TARC
|full-text-url=https://sci-hub.do/10.1016/j.cyto.2020.155305
}}
{{medline-entry
|title=Circulating [[BPI]]FB4 Levels Associate With and Influence the Abundance of Reparative Monocytes and Macrophages in Long Living Individuals.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32547549
 
 
|keywords=* FACS
* M2 macrophages
* immunity
* longevity
* patrolling-monocytes
* plasma
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7272600
}}
==BPIFB4==
 
{{medline-entry
|title=New Insights for [[BPIFB4]] in Cardiovascular Therapy.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32998388
 
 
|keywords=* BPIFB4
* aging
* cardiovascular disease
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7583974
}}
{{medline-entry
|title=LAV-[[BPIFB4]] associates with reduced frailty in humans and its transfer prevents frailty progression in old mice.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31461407
 
|mesh-terms=* Aged
* Aged, 80 and over
* Aging
* Animals
* Female
* Frailty
* Gene Expression Regulation
* Genotype
* Humans
* Longevity
* Male
* Mice
* Mice, Inbred C57BL
* Mice, Transgenic
* Phosphoproteins
* Specific Pathogen-Free Organisms
|keywords=* BPIFB4
* aging
* frailty
* longevity-associated variant-lav
* survival
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6738439
}}
==BRAF==
 
{{medline-entry
|title=Conditional reprograming culture conditions facilitate growth of lower grade glioma models.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/33258947
 
 
|keywords=* BRAFV600E
* Conditional reprogramming
* NF1
* Senescence
* low grade glioma
|full-text-url=https://sci-hub.do/10.1093/neuonc/noaa263
}}
{{medline-entry
|title=Active notch protects MAPK activated melanoma cell lines from MEK inhibitor cobimetinib.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/33202284
 
 
|keywords=* Cobimetinib (PubChem CID: 16222096)
* MEK
* Nirogacestat (PubChem CID:46224413)
* Notch
* Senescence
* Uveal melanoma
|full-text-url=https://sci-hub.do/10.1016/j.biopha.2020.111006
}}
{{medline-entry
|title=Mitochondrial metabolic reprograming via [[BRAF]] inhibition ameliorates senescence.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31421186
 
|mesh-terms=* Cell Proliferation
* Cells, Cultured
* Cellular Reprogramming
* Cellular Senescence
* Drug Evaluation, Preclinical
* Humans
* Mitochondria
* Proto-Oncogene Proteins B-raf
|keywords=* BRAF
* Metabolic reprogramming
* Mitochondrial function
* SB590885
* Senescence
|full-text-url=https://sci-hub.do/10.1016/j.exger.2019.110691
}}
==BRD2==
 
{{medline-entry
|title=Brd2 haploinsufficiency extends lifespan and healthspan in C57B6/J mice.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32559200
 
|mesh-terms=* Animals
* Female
* Fertility
* Grooming
* Haploinsufficiency
* Kidney
* Longevity
* Male
* Mice
* Mice, Inbred C57BL
* Transcription Factors
 
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7304595
}}
==BRD4==
 
{{medline-entry
|title=Inhibition of [[BRD4]] triggers cellular senescence through suppressing aurora kinases in oesophageal cancer cells.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32954665
 
 
|keywords=* BRD4
* aurora kinase
* cellular senescence
* oesophageal cancer
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7701500
}}
{{medline-entry
|title=[[BRD4]] contributes to LPS-induced macrophage senescence and promotes progression of atherosclerosis-associated lipid uptake.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32392533
 
 
|keywords=* BRD4
* gene expression
* inflammation
* macrophage
* senescence
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7288959
}}
{{medline-entry
|title=BET Proteins Are Required for Transcriptional Activation of the Senescent Islet Cell Secretome in Type 1 Diabetes.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31561444
 
|mesh-terms=* Animals
* Cell Cycle Proteins
* Cellular Senescence
* Diabetes Mellitus, Type 1
* Female
* Humans
* Insulin-Secreting Cells
* Islets of Langerhans
* Mice
* Mice, Inbred NOD
* Paracrine Communication
* Protein Binding
* Transcription Factors
* Transcriptional Activation
|keywords=* BET proteins
* beta cells
* senescence and SASP
* type 1 diabetes
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6801956
}}
==BTK==
 
{{medline-entry
|title=Amelioration of age-related brain function decline by Bruton's tyrosine kinase inhibition.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31736210
 
 
|keywords=* BTK
* cellular senescence
* healthspan
* p53
* progeria
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6974713
}}
==C2==
 
{{medline-entry
|title=[Effects of resistance training on mitochondrial function in skeletal muscle of aging rats].
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32744013
 
|mesh-terms=* Aging
* Animals
* Male
* Membrane Potential, Mitochondrial
* Mitochondria, Muscle
* Muscle, Skeletal
* Physical Conditioning, Animal
* Rats
* Rats, Sprague-Dawley
* Resistance Training
|keywords=* fusion protein 2
* mitochondria
* quadriceps
* rats
* resistance training
|full-text-url=https://sci-hub.do/10.12047/j.cjap.5861.2020.037
}}
{{medline-entry
|title=Structural and functional characterization of Solanum lycopersicum phosphatidylinositol 3-kinase [[C2]] domain.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31972387
 
|mesh-terms=* Animals
* C2 Domains
* Lycopersicon esculentum
* Phosphatidylinositol 3-Kinase
* Plants, Genetically Modified
* Protein Binding
* Tobacco
|keywords=* C2 domain
* Membrane binding
* Phosphatidylinositol 3-kinase
* Senescence
|full-text-url=https://sci-hub.do/10.1016/j.plaphy.2020.01.014
}}
==C3==
 
{{medline-entry
|title=Inverse association between periumbilical fat and longevity mediated by complement [[C3]] and cardiac structure.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/33221761
 
 
|keywords=* abdominal obesity
* cardiac structure
* complement C3
* longevity
* periumbilical fat
|full-text-url=https://sci-hub.do/10.18632/aging.104113
}}
{{medline-entry
|title=Complement [[C3]] deficiency ameliorates aging related changes in the kidney.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32882264
 
|mesh-terms=* Aging
* Animals
* Complement C3
* Inflammation
* Kidney
* Kidney Diseases
* Male
* Mice
* Mice, Inbred C57BL
* Mice, Knockout
|keywords=* Complement component 3
* Kidney disorder
* Senescence
|full-text-url=https://sci-hub.do/10.1016/j.lfs.2020.118370
}}
{{medline-entry
|title=Reduced sialylation triggers homeostatic synapse and neuronal loss in middle-aged mice.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32087947
 
|mesh-terms=* Aging
* Animals
* Brain
* Homeostasis
* Immunity, Innate
* Mice, Transgenic
* Neurons
* Racemases and Epimerases
* Sialic Acid Binding Immunoglobulin-like Lectins
* Sialic Acids
* Synapses
|keywords=* Aging
* GNE
* Glycocalyx
* Microglia
* Neurodegeneration
* Neuroinflammation
* Sialic acid
|full-text-url=https://sci-hub.do/10.1016/j.neurobiolaging.2020.01.008
}}
{{medline-entry
|title=[Comparative analysis of experimental data about the effects of various polyphenols on lifespan and aging.]
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31512417
 
|mesh-terms=* Animals
* Antioxidants
* Female
* Longevity
* Male
* Mice
* Mice, Inbred BALB C
* Polyphenols
* Survival Analysis
|keywords=* BP-C3
* Gompertz model
* SkQ1
* aging
* herbal extracts
* lifespan
* metformin
* polyphenols
* resveratrol
* tocopherol
 
}}
==C5==
 
{{medline-entry
|title=The [[C5]]-75 Program: Meeting the Need for Efficient, Pragmatic Frailty Screening and Management in Primary Care.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32638663
 
 
|keywords=* aging
* case-finding
* co-morbid conditions
* comorbidité
* dépistage
* fragilité
* frailty
* primary care
* recherche de cas
* screening
* soins de première ligne
* vieillissement
|full-text-url=https://sci-hub.do/10.1017/S0714980820000161
}}
{{medline-entry
|title=Can a relatively large spinal cord for the dural sac influence severity of paralysis in elderly patients with cervical spinal cord injury caused by minor trauma?
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32590805
 
|mesh-terms=* Aged
* Aged, 80 and over
* Cervical Vertebrae
* Female
* Geriatrics
* Humans
* Japan
* Magnetic Resonance Imaging
* Male
* Paralysis
* Severity of Illness Index
* Spinal Canal
* Spinal Cord
* Spinal Cord Injuries
* Tomography, X-Ray Computed
* Wounds and Injuries
 
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7328921
}}
==C6==
 
{{medline-entry
|title=Evolution of the Aroma of Treixadura Wines during Bottle Aging.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/33049919
 
 
|keywords=* bottle aging
* flavor profile
* sensory evaluation
* volatile composition
* white wine
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7600726
}}
{{medline-entry
|title=D-galactose induces senescence of glioblastoma cells through YAP-CDK6 pathway.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32991321
 
 
|keywords=* CDK6
* D-galatose
* YAP
* cellular senescence
* glioblastoma
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7585072
}}
==C7==
 
{{medline-entry
|title=The Vertebral Artery Convergence to the Cervical Spine in Elders.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32337923
 
|mesh-terms=* Aged
* Aged, 80 and over
* Aging
* Cervical Vertebrae
* Computed Tomography Angiography
* Cross-Sectional Studies
* Female
* Humans
* Male
* Middle Aged
* Retrospective Studies
* Vertebral Artery
|keywords=*  angiography
*  computed tomography
*  osteoarthritis
*  spine
*  vertebral artery
* aging
|full-text-url=https://sci-hub.do/10.3897/folmed.61.e39418
}}
==C9==
 
{{medline-entry
|title=[[C9]]orf72 in myeloid cells suppresses STING-induced inflammation.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32814898
 
|mesh-terms=* Aging
* Amyotrophic Lateral Sclerosis
* Animals
* C9orf72 Protein
* Dendritic Cells
* Encephalomyelitis, Autoimmune, Experimental
* Female
* Humans
* Inflammation
* Interferon Type I
* Membrane Proteins
* Mice
* Myeloid Cells
* Neoplasms
* T-Lymphocytes
 
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7484469
}}
{{medline-entry
|title=Glycine-alanine dipeptide repeats spread rapidly in a repeat length- and age-dependent manner in the fly brain.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31843021
 
|mesh-terms=* Aging
* Alanine
* Animals
* Animals, Genetically Modified
* Brain
* C9orf72 Protein
* DNA Repeat Expansion
* Dipeptides
* Drosophila
* Female
* Glycine
|keywords=* Ageing
* C9orf72
* Dipeptide repeat proteins
* Drosophila
* PolyGA
* Repeat size
* Spread
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6916080
}}
{{medline-entry
|title=Human iPSC-derived astrocytes from ALS patients with mutated [[C9]]ORF72 show increased oxidative stress and neurotoxicity.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31787569
 
|mesh-terms=* Amyotrophic Lateral Sclerosis
* Animals
* Astrocytes
* Biomarkers
* C9orf72 Protein
* Cells, Cultured
* Cellular Reprogramming
* Cellular Senescence
* Cerebral Cortex
* Disease Models, Animal
* Gene Expression Profiling
* Glutamic Acid
* Humans
* Induced Pluripotent Stem Cells
* Mice
* Motor Neurons
* Mutation
* Oxidative Stress
* Proteomics
* Reactive Oxygen Species
|keywords=* Amyotrophic lateral sclerosis
* Astrocytes
* Neurotoxicity
* Oxidative stress
* Senescence
* iPSC
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6921360
}}
==C9orf72==
 
{{medline-entry
|title=Carriership of two copies of [[C9orf72]] hexanucleotide repeat intermediate-length alleles is a risk factor for ALS in the Finnish population.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/33168078
 
 
|keywords=* ALS
* Aging
* C9orf72
* Case-control analysis
* Intermediate repeats
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7654028
}}
==CA1==
 
{{medline-entry
|title=The relation between tau pathology and granulovacuolar degeneration of neurons.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/33069844
 
 
|keywords=* AT8
* Aging
* CA1
* Casein kinase 1δ
* Congo red
* Dorsal raphe nucleus
* Locus coeruleus
* Neurodegeneration
* Tau pathology
|full-text-url=https://sci-hub.do/10.1016/j.nbd.2020.105138
}}
{{medline-entry
|title=Memory and dendritic spines loss, and dynamic dendritic spines changes are age-dependent in the rat.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32950615
 
 
|keywords=* Aging
* Hippocampus
* Locomotor activity
* Memory and learning
* Prefrontal cortex
* Pyramidal neurons
* dendritic spines
|full-text-url=https://sci-hub.do/10.1016/j.jchemneu.2020.101858
}}
{{medline-entry
|title=Deregulated expression of a longevity gene, Klotho, in the C9orf72 deletion mice with impaired synaptic plasticity and adult hippocampal neurogenesis.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32887666
 
 
|keywords=* Amyotrophic lateral sclerosis (ALS)
* C9ORF72
* Dentate gyrus, adult neurogenesis
* Frontotemporal dementia (FTD)
* Klotho
* Long-term depression (LTD)
* Long-term potentiation (LTP)
* Longevity
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7473815
}}
{{medline-entry
|title=COX5A Plays a Vital Role in Memory Impairment Associated With Brain Aging [i]via[/i] the BDNF/ERK1/2 Signaling Pathway.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32754029
 
 
|keywords=* BDNF
* COX5A
* ERK1/2
* brain senescence
* memory impairment
* mitochondria
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7365906
}}
{{medline-entry
|title=Changes of fat-mass and obesity-associated protein expression in the hippocampus in animal models of high-fat diet-induced obesity and D-galactose-induced aging.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32647628
 
 
|keywords=* Aging
* Fto
* Hippocampus
* Mice
* Obesity
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7336480
}}
{{medline-entry
|title=Phenylbutyrate ameliorates prefrontal cortex, hippocampus, and nucleus accumbens neural atrophy as well as synaptophysin and GFAP stress in aging mice.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32531811
 
 
|keywords=* aging
* dendrites
* hippocampus
* memory and learning
* nucleus accumbens
* prefrontal cortex
* sodium phenylbutyrate
|full-text-url=https://sci-hub.do/10.1002/syn.22177
}}
{{medline-entry
|title=Heterogeneity in brain distribution of activated microglia and astrocytes in a rat ischemic model of Alzheimer's disease after 2 years of survival.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32501292
 
 
|keywords=* Alzheimer’s disease
* aging
* brain ischemia
* glia
* neuroinflammation
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7343500
}}
{{medline-entry
|title=Hippocampal Subregion Transcriptomic Profiles Reflect Strategy Selection during Cognitive Aging.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32376783
 
|mesh-terms=* Animals
* Cognitive Aging
* Dentate Gyrus
* Hippocampus
* Maze Learning
* Rats
* Rats, Inbred F344
* Spatial Memory
* Transcriptome
|keywords=* aging
* hippocampus
* pattern separation
* reference memory
* spatial discrimination
* transcription
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7326352
}}
{{medline-entry
|title=Associations between pattern separation and hippocampal subfield structure and function vary along the lifespan: A 7 T imaging study.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32371923
 
|mesh-terms=* Adult
* Age Factors
* Aged
* Brain Mapping
* Female
* Hippocampus
* Humans
* Longevity
* Magnetic Resonance Imaging
* Male
* Middle Aged
* Young Adult
 
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7200747
}}
{{medline-entry
|title=Laminarin Pretreatment Provides Neuroprotection against Forebrain Ischemia/Reperfusion Injury by Reducing Oxidative Stress and Neuroinflammation in Aged Gerbils.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32326571
 
 
|keywords=* aging
* laminarin
* neuroinflammation
* neuroprotection
* oxidative stress
* transient cerebral ischemia
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7230782
}}
{{medline-entry
|title=Age-dependent Alteration in Mitochondrial Dynamics and Autophagy in Hippocampal Neuron of Cannabinoid CB1 Receptor-deficient Mice.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32294520
 
 
|keywords=* Aging
* CB1 receptor
* Hippocampus
* Mitochondria
* Mitophagy
|full-text-url=https://sci-hub.do/10.1016/j.brainresbull.2020.03.014
}}
{{medline-entry
|title=Functional Connectivity of Hippocampal CA3 Predicts Neurocognitive Aging via [[CA1]]-Frontal Circuit.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32239141
 
 
|keywords=* aging
* functional connectivity
* hippocampus
* spatial memory
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7325802
}}
{{medline-entry
|title=Integration of qRT-PCR and Immunohistochemical Techniques for mRNA Expression and Localization of m1AChR in the Brain of Aging Rat.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32219760
 
 
|keywords=* Acetylcholine
* Aging
* Brain
* Immunohistochemistry
* m1AChR
* qRT-PCR
|full-text-url=https://sci-hub.do/10.1007/978-1-0716-0471-7_23
}}
{{medline-entry
|title=Role of Eclipta prostrata extract in improving spatial learning and memory deficits in D-galactose-induced aging in rats.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32186114
 
|mesh-terms=* Aging
* Animals
* Behavior, Animal
* CA1 Region, Hippocampal
* Catalase
* Dopamine
* Eclipta
* Galactose
* Gene Expression Regulation, Enzymologic
* Glutathione Peroxidase
* Glutathione Reductase
* Male
* Memory Disorders
* Nitric Oxide
* Nitric Oxide Synthase Type II
* Norepinephrine
* Plant Extracts
* RNA, Messenger
* Rats
* Rats, Sprague-Dawley
* Serotonin
* Spatial Learning
* Superoxide Dismutase
|keywords=* Antioxidants
* Eclipta
* Galactose
* Memory disorders
* Spatial learning
 
}}
{{medline-entry
|title=Differential annualized rates of hippocampal subfields atrophy in aging and future Alzheimer's clinical syndrome.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32107063
 
|mesh-terms=* Aged
* Aging
* Alzheimer Disease
* Atrophy
* Cohort Studies
* Cross-Sectional Studies
* Dentate Gyrus
* Female
* Hippocampus
* Humans
* Magnetic Resonance Imaging
* Male
* Neuropsychological Tests
* Risk
|keywords=* Aging
* Alzheimer's disease
* Hippocampal subfields
* MRI
|full-text-url=https://sci-hub.do/10.1016/j.neurobiolaging.2020.01.011
}}
{{medline-entry
|title=Rectification of radiotherapy-induced cognitive impairments in aged mice by reconstituted Sca-1  stem cells from young donors.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32028989
 
|mesh-terms=* Animals
* Behavior, Animal
* Cognitive Dysfunction
* Dendritic Spines
* Hematopoietic Stem Cell Transplantation
* Hippocampus
* Humans
* Long-Term Potentiation
* Maze Learning
* Memory
* Mice
* Neurons
* Radiotherapy
* Recovery of Function
* Spinocerebellar Ataxias
* Treatment Outcome
|keywords=* Aging
* Bone marrow stem cells
* Learning and memory
* Microglia
* Radiotherapy
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7006105
}}
{{medline-entry
|title=Increasing neurogenesis refines hippocampal activity rejuvenating navigational learning strategies and contextual memory throughout life.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31919362
 
|mesh-terms=* Aging
* Animals
* Cyclin D1
* Cyclin-Dependent Kinase 4
* Female
* Hippocampus
* Learning
* Memory
* Memory Consolidation
* Mice
* Mice, Inbred C57BL
* Neural Stem Cells
* Neurogenesis
 
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6952376
}}
{{medline-entry
|title=Memory Performance Correlates of Hippocampal Subfield Volume in Mild Cognitive Impairment Subtype.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31849620
 
 
|keywords=* aging
* hippocampus
* memory
* mild cognitive impairment
* neuroimaging
* subfields
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6897308
}}
{{medline-entry
|title=Spermidine protects from age-related synaptic alterations at hippocampal mossy fiber-CA3 synapses.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31873156
 
|mesh-terms=* Aging
* Animals
* CA3 Region, Hippocampal
* Long-Term Potentiation
* Mice
* Mossy Fibers, Hippocampal
* Spermidine
* Synaptic Transmission
* Synaptic Vesicles
 
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6927957
}}
{{medline-entry
|title=Methylene blue inhibits Caspase-6 activity, and reverses Caspase-6-induced cognitive impairment and neuroinflammation in aged mice.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31843022
 
|mesh-terms=* Aging
* Animals
* Caspase 6
* Caspase Inhibitors
* Cognitive Dysfunction
* Female
* Humans
* Inflammation
* Male
* Methylene Blue
* Mice
* Mice, Inbred C57BL
* Mice, Knockout
* Mice, Transgenic
|keywords=* Alzheimer disease
* Axonal degeneration
* Caspase-6
* Caspase-6 inhibitor
* Hippocampal CA1
* Hippocampal fibres
* Methylene blue
* Synaptic plasticity
* White matter
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6915996
}}
{{medline-entry
|title=Long-term Memory Upscales Volume of Postsynaptic Densities in the Process that Requires Autophosphorylation of αCaMKII.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31800021
 
 
|keywords=* CA1 area
* CaMKII
* IntelliCages
* aging
* dendritic spines
* memory
* postsynaptic density
|full-text-url=https://sci-hub.do/10.1093/cercor/bhz261
}}
{{medline-entry
|title=PACAP27 mitigates an age-dependent hippocampal vulnerability to PGJ2-induced spatial learning deficits and neuroinflammation in mice.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31769222
 
 
|keywords=* CA1
* CA3
* Fluoro-Jade C
* aging
* microglia
* radial arm maze
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6955932
}}
{{medline-entry
|title=Inhibition of oxidative stress by testosterone improves synaptic plasticity in senescence accelerated mice.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31746286
 
|mesh-terms=* Aging
* Animals
* Male
* Mice
* Neuronal Plasticity
* Oxidative Stress
* Random Allocation
* Receptors, N-Methyl-D-Aspartate
* Testosterone
|keywords=* Alzheimer’s disease
* N-methyl-D-aspartate receptor-1
* Senescence accelerated mouse
* Testosterone
* oxidative stress
|full-text-url=https://sci-hub.do/10.1080/15287394.2019.1683988
}}
{{medline-entry
|title=Restored presynaptic synaptophysin and cholinergic inputs contribute to the protective effects of physical running on spatial memory in aged mice.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31470103
 
|mesh-terms=* Aging
* Animals
* Cholinergic Neurons
* Hippocampus
* Mice
* Mice, Inbred C57BL
* Physical Conditioning, Animal
* Presynaptic Terminals
* Spatial Memory
* Synaptophysin
|keywords=* Aging
* Cholinergic cells
* Hippocampus
* Memory
* Physical training
* Presynaptic terminals
* Synaptophysin
|full-text-url=https://sci-hub.do/10.1016/j.nbd.2019.104586
}}
{{medline-entry
|title=Senescent neurophysiology: Ca  signaling from the membrane to the nucleus.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31394200
 
|mesh-terms=* Aging
* Animals
* CA1 Region, Hippocampal
* Calcium Signaling
* Cell Nucleus
* Epigenesis, Genetic
* Excitatory Postsynaptic Potentials
* Humans
* Membrane Potentials
* Neuronal Plasticity
* Pyramidal Cells
* Receptors, N-Methyl-D-Aspartate
|keywords=* Afterhyperpolarization
* Aging
* Epigenetics
* Hippocampus
* N-methyl-D-aspartate receptor
* Synaptic plasticity
* Transcription
|full-text-url=https://sci-hub.do/10.1016/j.nlm.2019.107064
}}
==CA2==
 
{{medline-entry
|title=Maintaining Aging Hippocampal Function with Safe and Feasible Shaking Exercise in SAMP10 Mice.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32526748
 
 
|keywords=* Aging
* Behavior analysis
* Hippocampus
* Shaking exercise
* Spatial cognition
|full-text-url=https://sci-hub.do/10.1159/000507884
}}
{{medline-entry
|title=One-year Follow-up Study of Hippocampal Subfield Atrophy in Alzheimer's Disease and Normal Aging.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32008518
 
|mesh-terms=* Aged
* Aged, 80 and over
* Aging
* Alzheimer Disease
* Atrophy
* Case-Control Studies
* Cognitive Dysfunction
* Disease Progression
* Female
* Follow-Up Studies
* Hippocampus
* Humans
* Magnetic Resonance Imaging
* Male
* Neuroimaging
|keywords=* Alzheimer's disease
* biomarker
* hippocampal
* mild cognitive impairment
* neurodegenerative diseases
* normal aging
* radial distance
* subfield atrophy
|full-text-url=https://sci-hub.do/10.2174/1573405615666190327102052
}}
{{medline-entry
|title=Maturation of PNN and ErbB4 Signaling in Area [[CA2]] during Adolescence Underlies the Emergence of PV Interneuron Plasticity and Social Memory.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31665627
 
|mesh-terms=* Aging
* Animals
* Animals, Newborn
* CA2 Region, Hippocampal
* Interneurons
* Long-Term Synaptic Depression
* Male
* Memory
* Mice
* Mice, Inbred C57BL
* Neural Inhibition
* Neuregulin-1
* Neuronal Plasticity
* Parvalbumins
* Receptor, ErbB-4
* Receptors, Opioid, delta
* Signal Transduction
* Social Behavior
* Synapses
* gamma-Aminobutyric Acid
|keywords=* ErbB4
* adolescence
* area CA2
* delta opioid receptors
* hippocampus
* long-term depression
* neuregulin 1
* parvalbumin interneuron
* perineuronal net
* social memory
|full-text-url=https://sci-hub.do/10.1016/j.celrep.2019.09.044
}}
==CA3==
 
{{medline-entry
|title=Features of Postnatal Hippocampal Development in a Rat Model of Sporadic Alzheimer's Disease.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32581685
 
 
|keywords=* Alzheimer’s disease
* OXYS rats
* aging
* hippocampal mossy fibers
* hippocampus
* neurogenesis
* postnatal development
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7289999
}}
{{medline-entry
|title=Age-Related Changes in Synaptic Plasticity Associated with Mossy Fiber Terminal Integration during Adult Neurogenesis.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32332082
 
 
|keywords=* aging
* conditional transgenic
* giant synapse
* stratum lucidum
* synaptogenesis
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7240290
}}
{{medline-entry
|title=Metabotropic Glutamate Receptors at the Aged Mossy Fiber - [[CA3]] Synapse of the Hippocampus.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31917351
 
 
|keywords=* aging
* hippocampal area CA3
* mGluRs
* mossy fibers
* synaptic transmission
|full-text-url=https://sci-hub.do/10.1016/j.neuroscience.2019.12.016
}}
==CACNA1S==
 
{{medline-entry
|title=Increased calcium channel in the lamina propria of aging rat.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31682233
 
|mesh-terms=* Aging
* Animals
* Calcium Channel Blockers
* Calcium Channels
* Cell Line
* Fibroblasts
* Gene Expression Regulation
* Humans
* Larynx
* Male
* Mucous Membrane
* Rats
* Rats, Sprague-Dawley
* Verapamil
|keywords=* aging
* calcium channel
* extracellular matrix
* vocal fold
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6834399
}}
==CAD==
 
{{medline-entry
|title=Serum soluble Klotho is inversely related to coronary artery calcification assessed by intravascular ultrasound in patients with stable coronary artery disease.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/33303310
 
 
|keywords=* Aging
* Coronary artery calcification
* Intravascular ultrasound
* Klotho
|full-text-url=https://sci-hub.do/10.1016/j.jjcc.2020.11.014
}}
{{medline-entry
|title=Shear bond strengths of aged and non-aged [[CAD]]/CAM materials after different surface treatments.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/33149848
 
 
|keywords=* Bond strength
* Computer-aided design and computer-aided manufacturing (CAD/CAM)
* Laser
* Repair
* Surface treatment
* Thermal aging
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7604239
}}
{{medline-entry
|title=Prediction of Early Postoperative Major Cardiac Events and In-Hospital Mortality in Elderly Hip Fracture Patients: The Role of Different Types of Preoperative Cardiac Abnormalities on Echocardiography Report.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32546993
 
|mesh-terms=* Aged
* Aortic Valve Stenosis
* Cardiovascular Diseases
* Comorbidity
* Echocardiography
* Female
* Fracture Fixation
* Hip Fractures
* Hospital Mortality
* Humans
* Male
* Postoperative Complications
* Prognosis
* Risk Factors
|keywords=* aging
* echocardiographic abnormality
* hip fracture surgery
* mortality
* postoperative cardiac complications
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7266334
}}
{{medline-entry
|title=[Polymorbidity in elderly patients needing myocardial revascularization (a review article).]
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31800187
 
|mesh-terms=* Aged
* Cognitive Dysfunction
* Coronary Artery Disease
* Humans
* Myocardial Revascularization
* Quality of Life
* Risk
|keywords=* aging
* elderly
* ischemic heart disease
* myocardial revascularization
* polymorbidity
 
}}
{{medline-entry
|title=Fracture force of [[CAD]]/CAM resin composite crowns after in vitro aging.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31712983
 
|mesh-terms=* Ceramics
* Composite Resins
* Computer-Aided Design
* Crowns
* Dental Porcelain
* Dental Restoration Failure
* Dental Stress Analysis
* Humans
* Materials Testing
|keywords=* Aging
* CAD/CAM
* CAD/CAM bloc
* Dental material
* Fit
* Preparation
* Resin composite
* Resin-based material
* Storage
* TCML
|full-text-url=https://sci-hub.do/10.1007/s00784-019-03099-1
}}
{{medline-entry
|title=Clinical performance of chairside monolithic lithium disilicate glass-ceramic [[CAD]]-CAM crowns.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31565848
 
|mesh-terms=* Ceramics
* Computer-Aided Design
* Crowns
* Dental Porcelain
* Dental Prosthesis Design
* Humans
* Materials Testing
|keywords=* CAD-CAM
* chairside
* dental crowns
* lithium disilicate
* longevity
* survival
|full-text-url=https://sci-hub.do/10.1111/jerd.12531
}}
{{medline-entry
|title=Acute resveratrol supplementation in coronary artery disease: towards patient stratification.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31429599
 
|mesh-terms=* Aged
* Biomarkers
* Brachial Artery
* Cardiac Rehabilitation
* Coronary Artery Bypass
* Coronary Artery Disease
* Cross-Over Studies
* Exercise Therapy
* Female
* Humans
* Kinetics
* Male
* Middle Aged
* Oxygen
* Oxygen Consumption
* Percutaneous Coronary Intervention
* Resveratrol
* Single-Blind Method
* Treatment Outcome
* Vasodilation
|keywords=* Antioxidant
* aging
* endothelial dysfunction
* oxygen uptake
|full-text-url=https://sci-hub.do/10.1080/14017431.2019.1657584
}}
==CARM1==
 
{{medline-entry
|title=[[CARM1]] regulates senescence during airway epithelial cell injury in COPD pathogenesis.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31461302
 
|mesh-terms=* Aged
* Animals
* Apoptosis
* Cell Differentiation
* Cell Proliferation
* Cellular Senescence
* Epithelial Cells
* Female
* Humans
* Male
* Mice, Inbred C57BL
* Mice, Knockout
* Middle Aged
* Naphthalenes
* Protein-Arginine N-Methyltransferases
* Pulmonary Disease, Chronic Obstructive
* Respiratory Mucosa
* Wound Healing
|keywords=* CARM1
* COPD
* airway epithelium
* senescence
|full-text-url=https://sci-hub.do/10.1152/ajplung.00441.2018
}}
==CASP3==
 
{{medline-entry
|title=Does cartilage ERα overexpression correlate with osteoarthritic chondrosenescence? Indications from [i]Labisia pumila[/i] OA mitigation.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31502578
 
|mesh-terms=* Aging
* Animals
* Bone Development
* Cartilage
* Chondrocytes
* Diclofenac
* Disease Models, Animal
* Estrogen Receptor alpha
* Flavonoids
* Gallic Acid
* Gene Expression Regulation
* Humans
* Iodoacetates
* Matrix Metalloproteinase 13
* Metabolism
* Osteoarthritis
* Ovariectomy
* Plant Extracts
* Primulaceae
* Rats
 
 
}}
==CAT==
 
{{medline-entry
|title=Training improves the handling of inhaler devices and reduces the severity of symptoms in geriatric patients suffering from chronic-obstructive pulmonary disease.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/33036566
 
 
|keywords=* Chronic-obstructive pulmonary disease - Inhaler devices
* Compliance
* Geriatrics
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7547456
}}
{{medline-entry
|title=7-chloro-4-(phenylselanyl) quinoline co-treatment prevent oxidative stress in diabetic-like phenotype induced by hyperglycidic diet in Drosophila melanogaster.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32931926
 
 
|keywords=* 4-PSQ
* 7-chloro-4-(phenylselanyl) quinolone
* Antioxidant effect
* Diabetic-like phenotype
* Hyperglycidic diet
* Longevity
* Oxidative stress
|full-text-url=https://sci-hub.do/10.1016/j.cbpc.2020.108892
}}
{{medline-entry
|title=Aging influences in the blood-brain barrier permeability and cerebral oxidative stress in sepsis.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32827711
 
 
|keywords=* Aging
* Blood-brain barrier
* Brain
* Oxidative stress
* Sepsis
|full-text-url=https://sci-hub.do/10.1016/j.exger.2020.111063
}}
{{medline-entry
|title=2 -Deoxy - d-glucose at chronic low dose acts as a caloric restriction mimetic through a mitohormetic induction of ROS in the brain of accelerated senescence model of rat.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32559563
 
 
|keywords=* 2-Deoxy- d-glucose
* Aging
* Brain
* CRM
* Mitohormosis
* ROS
|full-text-url=https://sci-hub.do/10.1016/j.archger.2020.104133
}}
{{medline-entry
|title=Ceftriaxone improves senile neurocognition damages induced by D-galactose in mice.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32440324
 
 
|keywords=* Aging
* Ceftriaxone
* D-galactose
* Mice
* Oxidative stress
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7229512
}}
{{medline-entry
|title=Ginsenoside Rg1 protects against d-galactose induced fatty liver disease in a mouse model via FOXO1 transcriptional factor.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32437790
 
|mesh-terms=* Animals
* Antioxidants
* Cellular Senescence
* Disease Models, Animal
* Fatty Liver
* Forkhead Box Protein O1
* Galactose
* Ginsenosides
* Lipid Peroxidation
* Male
* Medicine, Chinese Traditional
* Mice
* Mice, Inbred C57BL
* Oxidative Stress
* Protective Agents
* Transcription Factors
|keywords=* D-galactose
* FOXO1
* Non-alcoholic fatty liver disease
* Rg1
* Senescence
|full-text-url=https://sci-hub.do/10.1016/j.lfs.2020.117776
}}
{{medline-entry
|title=Effects of long-term intermittent versus chronic calorie restriction on oxidative stress in a mouse cancer model.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31424629
 
|mesh-terms=* Aging
* Animals
* Antioxidants
* Caloric Restriction
* Catalase
* Erythrocytes
* Female
* Glutathione
* Lipid Peroxidation
* Malondialdehyde
* Mammary Neoplasms, Experimental
* Mice, Inbred C57BL
* Oxidative Stress
* Superoxide Dismutase
|keywords=* MMTV-TGF-α mice
* breast cancer
* energy restriction
* intermittent calorie restriction
* mammary tumor
* oxidative stress
|full-text-url=https://sci-hub.do/10.1002/iub.2145
}}
{{medline-entry
|title=The Toxicity of Nonaged and Aged Coated Silver Nanoparticles to Freshwater Alga Raphidocelis subcapitata.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31403715
 
|mesh-terms=* Aquatic Organisms
* Chlorophyta
* Fresh Water
* Hydrodynamics
* Lipid Peroxidation
* Metal Nanoparticles
* Particle Size
* Reactive Oxygen Species
* Silver
* Static Electricity
* Toxicity Tests
|keywords=* Aquatic toxicology
* Ecotoxicology
* Environmental fate
* Heavy metals
* Nanoparticle aging
* Nanotoxicology
|full-text-url=https://sci-hub.do/10.1002/etc.4549
}}
==CBS==
 
{{medline-entry
|title=Permanent cystathionine-β-Synthase gene knockdown promotes inflammation and oxidative stress in immortalized human adipose-derived mesenchymal stem cells, enhancing their adipogenic capacity.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32800520
 
 
|keywords=* Cellular senescence
* Cystathionine β-synthase
* Human adipose-derived mesenchymal stem cells
* Inflammation
* Oxidative stress and adipogenesis
|full-text-url=https://sci-hub.do/10.1016/j.redox.2020.101668
}}
{{medline-entry
|title=Cardiovascular phenotype of mice lacking 3-mercaptopyruvate sulfurtransferase.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32027885
 
|mesh-terms=* Animals
* Antioxidants
* Cardiovascular System
* Cystathionine beta-Synthase
* Cystathionine gamma-Lyase
* Gene Expression Regulation, Enzymologic
* Hydrogen Sulfide
* Male
* Mice, Inbred C57BL
* Mice, Knockout
* Myocardial Reperfusion Injury
* Myocytes, Cardiac
* Nitric Oxide
* Phenotype
* Reactive Oxygen Species
* Sulfurtransferases
* Vasodilation
|keywords=* 3-mercaptopyruvate transferase (3-MST)
* Aging
* Blood pressure
* Myocardial infarction
* Nitric Oxide (NO)
* Reactive Oxygen Species (ROS)
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7657663
}}
==CBX3==
 
{{medline-entry
|title=Biological functions of chromobox (CBX) proteins in stem cell self-renewal, lineage-commitment, cancer and development.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32979540
 
 
|keywords=* Aging
* Bone
* CBX1
* CBX2
* CBX3
* CBX4
* CBX5
* CBX6
* CBX7
* CBX8
* Cancer
* Chromatin
* Development
* Epigenetics
* H3K27me3
* H3K9me3
* Lineage-commitment
* Osteoblast
* Senescence
* Stem cell
|full-text-url=https://sci-hub.do/10.1016/j.bone.2020.115659
}}
==CCK==
 
{{medline-entry
|title=Senolytic agent Quercetin ameliorates intervertebral disc degeneration via the Nrf2/NF-κB axis.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/33242601
 
 
|keywords=* Intervertebral disc degeneration
* NF-κB pathway
* Nrf2
* Quercetin
* Senescence
|full-text-url=https://sci-hub.do/10.1016/j.joca.2020.11.006
}}
{{medline-entry
|title=Astragalus improve aging bone marrow mesenchymal stem cells (BMSCs) vitality and osteogenesis through VD-FGF23-Klotho axis.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32355520
 
 
|keywords=* Astragalus
* BMSCs
* VD-FGF23-Klotho axis
* aging
* osteogenesis differentiation
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7191145
}}
{{medline-entry
|title=Effects of Age on Acute Appetite-Related Responses to Whey-Protein Drinks, Including Energy Intake, Gastric Emptying, Blood Glucose, and Plasma Gut Hormone Concentrations-A Randomized Controlled Trial.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32268554
 
 
|keywords=* aging
* appetite
* energy intake
* gastric emptying
* glucose
* gut hormones
* whey protein
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7231005
}}
{{medline-entry
|title=Lactose induced redox-dependent senescence and activated Nrf2 pathway.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31934025
 
 
|keywords=* Lactose
* Nrf2
* ROS
* cellular senescence
* oxidative stress
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6949649
}}
{{medline-entry
|title=Quercetin Suppresses the Progression of Atherosclerosis by Regulating MST1-Mediated Autophagy in ox-LDL-Induced RAW264.7 Macrophage Foam Cells.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31816893
 
|mesh-terms=* Adenine
* Animals
* Atherosclerosis
* Autophagy
* Cell Survival
* Cellular Senescence
* Cyclin-Dependent Kinase Inhibitor p16
* Cyclin-Dependent Kinase Inhibitor p21
* Disease Progression
* Foam Cells
* Hepatocyte Growth Factor
* Lipid Metabolism
* Lipoproteins, LDL
* Mice
* Proto-Oncogene Proteins
* Quercetin
* RAW 264.7 Cells
* Sirolimus
* Up-Regulation
|keywords=* RAW264.7
* atherosclerosis
* autophagy
* quercetin
* senescence
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6928812
}}
{{medline-entry
|title=LncRNA AW112010 Promotes Mitochondrial Biogenesis and Hair Cell Survival: Implications for Age-Related Hearing Loss.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31781342
 
|mesh-terms=* Adenosine Triphosphate
* Aging
* Animals
* Cell Survival
* DNA-Binding Proteins
* Gene Silencing
* Hair Cells, Auditory
* Hearing Loss
* Mice
* Mitochondria
* Organelle Biogenesis
* RNA, Long Noncoding
* Resveratrol
* Signal Transduction
* Transcription Factors
 
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6855056
}}
{{medline-entry
|title=Effects of age on feeding response: Focus on the rostral C1 neuron and its glucoregulatory proteins.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31705967
 
 
|keywords=* Aging
* Catecholaminergic neurons
* Feeding response
* Glucoprivation
* Rostral ventrolateral medulla
|full-text-url=https://sci-hub.do/10.1016/j.exger.2019.110779
}}
{{medline-entry
|title=Ser-Tyr and Asn-Ala, vasorelaxing dipeptides found by comprehensive screening, reduce blood pressure via different age-dependent mechanisms.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31685714
 
|mesh-terms=* Aging
* Amino Acid Sequence
* Animals
* Antihypertensive Agents
* Blood Pressure
* Cholecystokinin
* Dipeptides
* Drug Evaluation, Preclinical
* Hypertension
* Male
* Mesenteric Arteries
* Nitric Oxide
* Peptide Library
* Proglumide
* Rats
* Rats, Inbred SHR
* Receptors, Cholecystokinin
* Vasodilation
* Vasodilator Agents
|keywords=* aging
* dipeptide library
* nitric oxide
* structure-activity relationship
* vasorelaxation
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6874431
}}
{{medline-entry
|title=Fisetin, via CKIP-1/REGγ, limits oxidized LDL-induced lipid accumulation and senescence in RAW264.7 macrophage-derived foam cells.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31655030
 
|mesh-terms=* Animals
* Autoantigens
* Carrier Proteins
* Cellular Senescence
* Flavonoids
* Foam Cells
* Lipid Metabolism
* Lipoproteins, LDL
* Mice
* Proteasome Endopeptidase Complex
* RAW 264.7 Cells
* Signal Transduction
|keywords=* CKIP-1/REGγ signaling
* Fisetin
* Lipid accumulation
* RAW264.7
* Senescence
|full-text-url=https://sci-hub.do/10.1016/j.ejphar.2019.172748
}}
==CCL11==
 
{{medline-entry
|title=CCL-11 or Eotaxin-1: An Immune Marker for Ageing and Accelerated Ageing in Neuro-Psychiatric Disorders.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32887304
 
 
|keywords=* Alzheimer’s disease
* CCL-11
* aging
* behaviour
* biomarkers
* brain
* cytokines
* eotaxin
* prevention
* schizophrenia
* stroke
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7558796
}}
==CCL17==
 
{{medline-entry
|title=Aging and chronic high-fat feeding negatively affects kidney size, function, and gene expression in CTRP1-deficient mice.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/33085906
 
 
|keywords=* aging
* heart
* kidney
* metabolism
* obesity
|full-text-url=https://sci-hub.do/10.1152/ajpregu.00139.2020
}}
==CCL19==
 
{{medline-entry
|title=Age-Related Gliosis Promotes Central Nervous System Lymphoma through [[CCL19]]-Mediated Tumor Cell Retention.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31526758
 
|mesh-terms=* Adolescent
* Adult
* Aged
* Aging
* Animals
* Astrocytes
* Blood-Brain Barrier
* Cell Line, Tumor
* Central Nervous System Neoplasms
* Chemokine CCL19
* Chemokine CXCL12
* Disease Models, Animal
* Female
* Gliosis
* Humans
* Intravital Microscopy
* Lymphoma
* Male
* Mice
* Mice, Transgenic
* Microscopy, Fluorescence, Multiphoton
* Middle Aged
* NF-kappa B
* Receptors, CCR7
* Time-Lapse Imaging
* Young Adult
|keywords=* CCL19
* CNSL
* CXCL12
* DLBCL
* PCNSL
* SCNSL
* gliosis
* lymphoma
* metastasis
* neuroinflammation
|full-text-url=https://sci-hub.do/10.1016/j.ccell.2019.08.001
}}
==CCL2==
 
{{medline-entry
|title=β1 Integrin regulates adult lung alveolar epithelial cell inflammation.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31873073
 
|mesh-terms=* Aging
* Alveolar Epithelial Cells
* Animals
* Cell Adhesion
* Chemokine CCL2
* Chemokines
* Disease Models, Animal
* Epithelium
* Integrin beta1
* Lung
* Macrophages
* Mice
* Mice, Inbred C57BL
* Mice, Knockout
* Pneumonia
* Pulmonary Disease, Chronic Obstructive
* Receptors, CCR2
|keywords=* COPD
* Inflammation
* Integrins
* Macrophages
* Pulmonology
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7098727
}}
==CCL20==
 
{{medline-entry
|title=p53 and p53-related mediators PAI-1 and IGFBP-3 are downregulated in peripheral blood mononuclear cells of HIV-patients exposed to non-nucleoside reverse transcriptase inhibitors.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32272174
 
 
|keywords=* Aging
* Antiretroviral drugs
* HIV
* Inflammation
* NNRTI
* Senescence
* p53
|full-text-url=https://sci-hub.do/10.1016/j.antiviral.2020.104784
}}
==CCL28==
 
{{medline-entry
|title=Age-related chemokine alterations affect IgA secretion and gut immunity in female mice.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32277312
 
 
|keywords=* Aging
* CCL25
* CCL28
* Gut immunity
* IgA
|full-text-url=https://sci-hub.do/10.1007/s10522-020-09877-9
}}
==CCN1==
 
{{medline-entry
|title=Sodium tanshinone IIA sulfonate restrains fibrogenesis through induction of senescence in mice with induced deep endometriosis.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32651107
 
 
|keywords=* Deep endometriosis
* Fibrogenesis
* Mouse
* Senescence
* Sodium tanshinone IIA sulfonate
|full-text-url=https://sci-hub.do/10.1016/j.rbmo.2020.04.006
}}
{{medline-entry
|title=Inhibition of cellular communication network factor 1 ([[CCN1]])-driven senescence slows down cartilage inflammaging and osteoarthritis.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32622876
 
 
|keywords=* CCN1
* Cartilage inflammaging
* Chondrocyte cluster
* Osteoarthritis
* Senescence
|full-text-url=https://sci-hub.do/10.1016/j.bone.2020.115522
}}
{{medline-entry
|title=The senescence-associated matricellular protein [[CCN1]] in plasma of human subjects with idiopathic pulmonary fibrosis.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31765873
 
|mesh-terms=* Aged
* Cellular Senescence
* Cysteine-Rich Protein 61
* Disease Progression
* Enzyme-Linked Immunosorbent Assay
* Female
* Humans
* Idiopathic Pulmonary Fibrosis
* Male
* Middle Aged
* Outcome Assessment, Health Care
* Predictive Value of Tests
* Survival Rate
|keywords=* CCN1
* Cellular senescence
* Idiopathic pulmonary fibrosis
* Transplant-free survival
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7023981
}}
==CCN3==
 
{{medline-entry
|title=[[CCN3]] Signaling Is Differently Regulated in Placental Diseases Preeclampsia and Abnormally Invasive Placenta.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/33304321
 
 
|keywords=* CCN3
* abnormally invasive placenta
* invasion
* preeclampsia
* senescence
* trophoblast
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7701218
}}
{{medline-entry
|title=[[CCN3]] (NOV) Drives Degradative Changes in Aging Articular Cartilage.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/33066270
 
 
|keywords=* CCN3
* NOV
* SASP
* aging
* cellular communication network factor 3
* oxidative stress
* p21
* p53
* primary chondrocytes
* senescence
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7593953
}}
==CCND1==
 
{{medline-entry
|title=Effects of hydrogen peroxide, doxorubicin and ultraviolet irradiation on senescence of human dental pulp stem cells.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32592933
 
|mesh-terms=* Cells, Cultured
* Cellular Senescence
* Dental Pulp
* Doxorubicin
* Humans
* Hydrogen Peroxide
* Stem Cells
* Ultraviolet Rays
|keywords=* Cell cycle
* ROS
* Stress induced senescence
* Ultraviolet irradiation
* p21
|full-text-url=https://sci-hub.do/10.1016/j.archoralbio.2020.104819
}}
==CCND3==
 
{{medline-entry
|title=The effect of aging on the biological and immunological characteristics of periodontal ligament stem cells.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32727592
 
 
|keywords=* Aging
* Immunosuppression
* Osteogenic differentiation
* Periodontal ligament stem cells
* Peripheral blood mononuclear cells
* Tissue engineering
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7392710
}}
==CCR2==
 
{{medline-entry
|title=Hip Fracture Leads to Transitory Immune Imprint in Older Patients.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/33072114
 
 
|keywords=* acute stress
* aging
* immune response
* inflammation
* regulation loop
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7533556
}}
{{medline-entry
|title=The CC-chemokine receptor 2 is involved in the control of ovarian folliculogenesis and fertility lifespan in mice.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32615332
 
 
|keywords=* Aging
* CCR2
* Fertility
* Follicle
* Ovary
|full-text-url=https://sci-hub.do/10.1016/j.jri.2020.103174
}}
{{medline-entry
|title=Deficit of resolution receptor magnifies inflammatory leukocyte directed cardiorenal and endothelial dysfunction with signs of cardiomyopathy of obesity.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32543720
 
 
|keywords=* inflammatory macrophage
* kidney function
* non-resolving inflammation
* obesogenic aging
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7704037
}}
{{medline-entry
|title=Tet2-mediated clonal hematopoiesis in nonconditioned mice accelerates age-associated cardiac dysfunction.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32154790
 
 
|keywords=* Aging
* Bone marrow transplantation
* Cardiology
* Hematopoietic stem cells
* Macrophages
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7213793
}}
{{medline-entry
|title=Inflammation and Ectopic Fat Deposition in the Aging Murine Liver Is Influenced by [[CCR2]].
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31843499
 
|mesh-terms=* Aging
* Animals
* Body Weight
* Chemokine CCL2
* Disease Models, Animal
* Female
* Gene Expression Profiling
* Inflammation
* Macrophages
* Male
* Mice
* Mice, Inbred C57BL
* Non-alcoholic Fatty Liver Disease
* Organ Size
* Receptors, CCR2
 
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7013280
}}
{{medline-entry
|title=Klotho-mediated targeting of CCL2 suppresses the induction of colorectal cancer progression by stromal cell senescent microenvironments.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31545552
 
|mesh-terms=* Aged
* Cell Line, Tumor
* Cell Movement
* Cell Proliferation
* Cellular Microenvironment
* Cellular Senescence
* Chemokine CCL2
* Colorectal Neoplasms
* Disease Progression
* Down-Regulation
* Doxorubicin
* Female
* Glucuronidase
* Human Umbilical Vein Endothelial Cells
* Humans
* Male
* Middle Aged
* NF-kappa B
* Neoplasm Invasiveness
* Proportional Hazards Models
* Signal Transduction
* Stromal Cells
|keywords=* CCL2
* Klotho
* colorectal cancer
* senescence
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6822285
}}
==CCR3==
 
{{medline-entry
|title=Low Molecular Weight Hyaluronan Induces an Inflammatory Response in Ovarian Stromal Cells and Impairs Gamete Development In Vitro.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32033185
 
|mesh-terms=* Aging
* Animals
* Extracellular Matrix
* Female
* Germ Cells
* Granulosa Cells
* Hyaluronan Receptors
* Hyaluronic Acid
* Inflammation
* Mice
* Mice, Inbred BALB C
* Mice, Inbred C57BL
* Molecular Weight
* Ovary
* Stromal Cells
|keywords=* hyaluronan fragments
* inflammation
* ovarian biology
* reproductive aging
* stroma
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7036885
}}
==CCR5==
 
{{medline-entry
|title=[Enhancement can do harm].
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31532388
 
|mesh-terms=* Adult
* Aged
* CRISPR-Cas Systems
* China
* Embryo Research
* Gene Editing
* Gene Silencing
* Genetic Enhancement
* Genome-Wide Association Study
* HIV Infections
* HIV-1
* Humans
* Longevity
* Middle Aged
* Receptors, CCR5
 
|full-text-url=https://sci-hub.do/10.1051/medsci/2019136
}}
==CCS==
 
{{medline-entry
|title=Frailty Significantly Associated with a Risk for Mid-term Outcomes in Elderly Chronic Coronary Syndrome Patients: a Prospective Study.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/33306315
 
 
|keywords=* Aging
* Canada
* Confidence Intervals
* Death
* Frail Elderly
* Frailty
* Heart
* Multivariate Analysis
* Prognosis
* Risk Factors
|full-text-url=https://sci-hub.do/10.21470/1678-9741-2019-0484
}}
{{medline-entry
|title=Microbleeds and Medial Temporal Atrophy Determine Cognitive Trajectories in Normal Aging: A Longitudinal PET-MRI Study.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32925053
 
 
|keywords=* Atrophy
* cognition
* imaging markers
* medial temporal lobe
* microbleeds
* normal aging
|full-text-url=https://sci-hub.do/10.3233/JAD-200559
}}
{{medline-entry
|title=Hippocampal Volume Loss, Brain Amyloid Accumulation, and APOE Status in Cognitively Intact Elderly Subjects.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31846965
 
|mesh-terms=* Aged
* Aged, 80 and over
* Amyloid beta-Peptides
* Apolipoprotein E4
* Brain
* Cognitive Aging
* Female
* Hippocampus
* Humans
* Longitudinal Studies
* Magnetic Resonance Imaging
* Male
* Positron-Emission Tomography
|keywords=* APOE
* Aging
* Amyloid
* Hippocampus
|full-text-url=https://sci-hub.do/10.1159/000504302
}}
{{medline-entry
|title=Amyloid Load, Hippocampal Volume Loss, and Diffusion Tensor Imaging Changes in Early Phases of Brain Aging.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31803008
 
 
|keywords=* APOE genotyping
* amyloid deposition
* magnetic resonance imaging
* normal aging
* positron emission tomography
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6872975
}}
{{medline-entry
|title=Lower bone mass is associated with subclinical atherosclerosis, endothelial dysfunction and carotid thickness in the very elderly.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31783200
 
 
|keywords=* Aging
* Endothelial dysfunction
* Osteoporosis
* Subclinical atherosclerosis
|full-text-url=https://sci-hub.do/10.1016/j.atherosclerosis.2019.11.007
}}
==CD14==
 
{{medline-entry
|title=Human innate immune cell crosstalk induces melanoma cell senescence.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32939325
 
 
|keywords=* NK cell
* cytokines
* melanoma
* senescence
* slanMo
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7470184
}}
{{medline-entry
|title=Fusion Potential of Human Osteoclasts In Vitro Reflects Age, Menopause, and In Vivo Bone Resorption Levels of Their Donors-A Possible Involvement of DC-STAMP.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32887359
 
 
|keywords=* CTX
* DC-STAMP
* DNA methylation
* aging
* cell fusion
* epigenetics
* menopause
* multinucleation
* osteoclast
* osteoclastogenesis
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7504560
}}
{{medline-entry
|title=Association of [[CD14]] with incident dementia and markers of brain aging and injury.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31818907
 
|mesh-terms=* Aged
* Aged, 80 and over
* Aging
* Atrophy
* Biomarkers
* Brain
* Cognitive Dysfunction
* Dementia
* Female
* Humans
* Incidence
* Lipopolysaccharide Receptors
* Longitudinal Studies
* Male
* Middle Aged
 
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7108812
}}
{{medline-entry
|title=Compromised Bone Healing in Aged Rats Is Associated With Impaired M2 Macrophage Function.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31681320
 
|mesh-terms=* Age Factors
* Aging
* Animals
* Antigens, CD
* Antigens, Differentiation, Myelomonocytic
* Biomarkers
* Bone Regeneration
* Bone and Bones
* Female
* Fractures, Bone
* Gene Expression
* Lipopolysaccharide Receptors
* Macrophages
* Osteotomy
* Rats, Sprague-Dawley
* Wound Healing
|keywords=* CD14+ cells
* aging
* angiogenesis
* bone regeneration
* compromised healing
* macrophage
* monocyte
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6813416
}}
==CD19==
 
{{medline-entry
|title=Sequential treatment with aT19 cells generates memory CAR-T cells and prolongs the lifespan of Raji-B-NDG mice.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31634527
 
|mesh-terms=* Animals
* Antigens, CD19
* Cell Line, Tumor
* Combined Modality Therapy
* Disease-Free Survival
* HEK293 Cells
* Healthy Volunteers
* Humans
* Immunologic Memory
* Immunotherapy, Adoptive
* Longevity
* Lymphoma, B-Cell
* Mice
* Neoplasm Recurrence, Local
* Receptors, Chimeric Antigen
* Recombinant Proteins
* Remission Induction
* T-Lymphocytes
* Time Factors
* Transduction, Genetic
* Transplantation, Autologous
* Xenograft Model Antitumor Assays
|keywords=* Autologous CD19 T cells
* Chimeric antigen receptor
* Memory T cells
* Sequential therapy
|full-text-url=https://sci-hub.do/10.1016/j.canlet.2019.10.022
}}
==CD27==
 
{{medline-entry
|title=The Interplay between [[CD27]]  and [[CD27]]  B Cells Ensures the Flexibility, Stability, and Resilience of Human B Cell Memory.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32130900
 
 
|keywords=* CD27
* VH repertoire
* aging
* germinal center
* immunodeficiency
* immunological memory
* memory B cells
* pregnancy
* spleen
* vaccine
|full-text-url=https://sci-hub.do/10.1016/j.celrep.2020.02.022
}}
{{medline-entry
|title=CMV-independent increase in [[CD27]]-CD28+ CD8+ EMRA T cells is inversely related to mortality in octogenarians.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31993214
 
 
|keywords=* Biomarkers
* Senescence
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6972903
}}
{{medline-entry
|title=Compartmentalized cytotoxic immune response leads to distinct pathogenic roles of natural killer and senescent CD8  T cells in human cutaneous leishmaniasis.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31925782
 
|mesh-terms=* CD56 Antigen
* CD57 Antigens
* Case-Control Studies
* Cellular Senescence
* Cytotoxicity, Immunologic
* Female
* Gene Expression Regulation
* Host-Parasite Interactions
* Humans
* Interferon-gamma
* Killer Cells, Natural
* Lectins, C-Type
* Leishmania braziliensis
* Leishmaniasis, Cutaneous
* Male
* Oligosaccharides
* Receptors, Immunologic
* Severity of Illness Index
* Sialyl Lewis X Antigen
* Signal Transduction
* Skin
* T-Lymphocytes, Cytotoxic
|keywords=*
Leishmania braziliensis
 
* CD8+ T cells
* cellular senescence
* cutaneous leishmaniasis
* immunopathology
* natural killer cells
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7078002
}}
{{medline-entry
|title=[[CD27]]- IgD- B cell memory subset associates with inflammation and frailty in elderly individuals but only in males.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31423147
 
 
|keywords=* Aging
* B cell
* Frailty
* Immunosenescence
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6693136
}}
==CD28==
 
{{medline-entry
|title=Premature CD4  T Cells Senescence Induced by Chronic Infection in Patients with Acute Coronary Syndrome.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/33269101
 
 
|keywords=* CD28null T cells
* CD4+ T cells
* acute coronary syndrome
* immunosenescence
* infection
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7673853
}}
{{medline-entry
|title=The IMMENSE Study: The Interplay Between iMMune and ENdothelial Cells in Mediating Cardiovascular Risk in Systemic Lupus Erythematosus.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/33193356
 
 
|keywords=* angiogenic T cells
* cardiovascular risk
* endothelial progenitor cells
* immunosenescence
* systemic lupus erythematosus
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7658008
}}
{{medline-entry
|title=Emergence of T cell immunosenescence in diabetic chronic kidney disease.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/33088331
 
 
|keywords=* BMI
* CKD
* Diabetes
* Immunosenescence
* T cell
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7574244
}}
{{medline-entry
|title=The relationship between Chlamydia pneumoniae infection and CD4/CD8 ratio, lymphocyte subsets in middle-aged and elderly individuals.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/33068732
 
 
|keywords=* CD4/CD8 ratio
* Chlamydia pneumoniae
* Immune profile
* Immunosenescence
* Lymphocyte subsets
|full-text-url=https://sci-hub.do/10.1016/j.micpath.2020.104541
}}
{{medline-entry
|title=Next steps in mechanisms of inflammaging.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32960694
 
 
|keywords=* Aging
* autophagy
* glutathione
* membrane potential
* mitochondria
* oxidative stress
|full-text-url=https://sci-hub.do/10.1080/15548627.2020.1822089
}}
{{medline-entry
|title=A randomized pilot trial to evaluate the benefit of the concomitant use of atorvastatin and Raltegravir on immunological markers in protease-inhibitor-treated subjects living with HIV.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32941476
 
|mesh-terms=* Adult
* Anti-HIV Agents
* Anticholesteremic Agents
* Atorvastatin
* CD4-Positive T-Lymphocytes
* CD8-Positive T-Lymphocytes
* Female
* HIV Infections
* HIV Protease Inhibitors
* Humans
* Immunosenescence
* Inflammation
* Lymphocyte Activation
* Male
* Middle Aged
* Pilot Projects
* Raltegravir Potassium
 
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7498036
}}
{{medline-entry
|title=Aging affects responsiveness of peripheral blood mononuclear cells to immunosuppression of periodontal ligament stem cells.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32663414
 
 
|keywords=* Periodontal ligament stem cells
* T lymphocytes
* age
* coculture
* cytokines
* immunophenotyping
* immunosenescence
* immunosuppression
* peripheral blood mononuclear cells
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7364836
}}
{{medline-entry
|title=Comparison of Donepezil, Memantine, Melatonin, and Liuwei Dihuang Decoction on Behavioral and Immune Endocrine Responses of Aged Senescence-Accelerated Mouse Resistant 1 Mice.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32477103
 
 
|keywords=* Liuwei Dihuang decoction
* aging
* cognition
* immune response
* inflammation
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7241684
}}
{{medline-entry
|title=Immunosenescent characteristics of T cells in young patients following haploidentical haematopoietic stem cell transplantation from parental donors.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32280463
 
 
|keywords=* CD28− T cells
* HaploSCT
* immune monitoring
* immunosenescence
* telomere length
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7142179
}}
{{medline-entry
|title=Diagnosis-independent loss of T-cell costimulatory molecules in individuals with cytomegalovirus infection.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32209361
 
 
|keywords=* Biological aging
* Cytomegalovirus
* Depression
* Immunosenescence
* Major depressive disorder
* Sex differences
* T-cells
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7594105
}}
{{medline-entry
|title=Accelerated immunosenescence in rheumatoid arthritis: impact on clinical progression.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32190092
 
 
|keywords=* Ageing
* Cell senescence
* Cognitive impairment
* Immune ageing
* Rheumatoid arthritis
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7068869
}}
{{medline-entry
|title=Accelerated immune aging was correlated with lupus-associated brain fog in reproductive-age systemic lupus erythematosus patients.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32107852
 
 
|keywords=* immunosenescence
* lupus-associated brain fog
* systemic lupus erythematosus
|full-text-url=https://sci-hub.do/10.1111/1756-185X.13816
}}
{{medline-entry
|title=T cells, aging and senescence.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32092501
 
 
|keywords=* Aging
* Senescence
* T cells
|full-text-url=https://sci-hub.do/10.1016/j.exger.2020.110887
}}
{{medline-entry
|title=Liver fibrosis and accelerated immune dysfunction (immunosenescence) among HIV-infected Russians with heavy alcohol consumption - an observational cross-sectional study.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31892306
 
|mesh-terms=* Adult
* Alcoholism
* CD28 Antigens
* CD4-Positive T-Lymphocytes
* CD57 Antigens
* CD8-Positive T-Lymphocytes
* Cross-Sectional Studies
* Female
* HIV Infections
* Hepatitis C
* Humans
* Immunologic Memory
* Immunosenescence
* Leukocyte Common Antigens
* Linear Models
* Liver Cirrhosis, Alcoholic
* Male
* Phenotype
* Randomized Controlled Trials as Topic
* Russia
* Zinc
|keywords=* Alcohol
* HIV
* Immune senescence
* Liver fibrosis
* Russia
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6938606
}}
{{medline-entry
|title=Effect of Allogenic Bone Marrow Mesenchymal Stem Cell Transplantation on T Cells of Old Mice.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31895587
 
 
|keywords=* aging
* cellular senescence
* memory T cells
* stem cell
|full-text-url=https://sci-hub.do/10.1089/cell.2019.0055
}}
{{medline-entry
|title=Peripheral antibody concentrations are associated with highly differentiated T cells and inflammatory processes in the human bone marrow.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31462901
 
 
|keywords=* Aging
* Antibodies
* B cells
* Bone marrow
* Exhaustion
* Immunosenescence
* Inflammation
* Pro-inflammatory
* Senescence
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6706884
}}
==CD33==
 
{{medline-entry
|title=Maximum reproductive lifespan correlates with [[CD33]]rSIGLEC gene number: Implications for NADPH oxidase-derived reactive oxygen species in aging.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31907986
 
|mesh-terms=* Animals
* Gene Dosage
* Humans
* Longevity
* NADPH Oxidases
* Neutrophils
* Reactive Oxygen Species
* Sialic Acid Binding Ig-like Lectin 3
* Whale, Killer
|keywords=*
CD33rSIGLEC
 
* NADPH-oxidase
* prolonged post-reproductive lifespan
* reactive oxygen species
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7018541
}}
==CD34==
 
{{medline-entry
|title=Comparing the Effect of TGF-β Receptor Inhibition on Human Perivascular Mesenchymal Stromal Cells Derived from Endometrium, Bone Marrow and Adipose Tissues.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/33271899
 
 
|keywords=* SUSD2
* adipose tissue
* apoptosis
* bone marrow
* clonogenicity
* endometrium
* menstrual fluid
* perivascular mesenchymal stromal cells
* placenta
* senescence
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7712261
}}
{{medline-entry
|title=ACE2/ACE imbalance and impaired vasoreparative functions of stem/progenitor cells in aging.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/33247425
 
 
|keywords=* ACE2
* Aging
* Angiotensin-(1-7)
* Hematopoietic stem/progenitor cells
* Ischemia
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7694587
}}
{{medline-entry
|title=Innovative Mind-Body Intervention Day Easy Exercise Increases Peripheral Blood [[CD34]]  Cells in Adults.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32841054
 
 
|keywords=* CD34+ cells
* aging
* day easy exercise
* mind–body intervention
|full-text-url=https://sci-hub.do/10.1177/0963689720952352
}}
{{medline-entry
|title=Human Thymic Involution and Aging in Humanized Mice.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32733465
 
 
|keywords=* aging
* human
* humanized mouse
* recent thymic emigrants
* thymus involution
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7358581
}}
{{medline-entry
|title=Coinhibition of activated p38 MAPKα and mTORC1 potentiates stemness maintenance of HSCs from SR1-expanded human cord blood [[CD34]]  cells via inhibition of senescence.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32602209
 
 
|keywords=* HSC stemness maintenance
* Stem Regenin 1
* cellular senescence
* ex vivo expansion
* human cord blood CD34+ cells
* mammalian target of rapamycin complex 1
* p38 mitogen-activated protein kinase α
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7695631
}}
{{medline-entry
|title=Bulk and single-cell gene expression analyses reveal aging human choriocapillaris has pro-inflammatory phenotype.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32531351
 
|mesh-terms=* Age Factors
* Aged
* Aged, 80 and over
* Aging
* Choroid
* Endothelial Cells
* Female
* Gene Expression Regulation
* Humans
* Infant
* Infant, Newborn
* Inflammation
* Inflammation Mediators
* Macular Degeneration
* Male
* Middle Aged
* Phenotype
* Sequence Analysis, RNA
* Single-Cell Analysis
|keywords=* Age-related macular degeneration
* Choriocapillaris
* Choroid
* Infant
* Pericytes
* Single-cell
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7396301
}}
{{medline-entry
|title=Mesenchymal stem cells repair bone marrow damage of aging rats and regulate autophagy and aging genes.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32432372
 
 
|keywords=* aging
* autophagy
* bone marrow injury
* mesenchymal stem cells
* repair
|full-text-url=https://sci-hub.do/10.1002/cbf.3548
}}
{{medline-entry
|title=Immune cell extracellular vesicles and their mitochondrial content decline with ageing.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31911808
 
 
|keywords=* Ageing
* Apoptotic bodies
* Exosomes
* Extracellular vesicles
* Immune cells
* Immunosenescence
* Inflammageing
* Microvesicles
* Mitochondria
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6942666
}}
{{medline-entry
|title=Young and elderly oral squamous cell carcinoma patients present similar angiogenic profile and predominance of M2 macrophages: Comparative immunohistochemical study.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31497915
 
|mesh-terms=* Adult
* Aged
* Aged, 80 and over
* Antigens, CD
* Antigens, Differentiation, Myelomonocytic
* Carcinoma, Squamous Cell
* Female
* Humans
* Immunohistochemistry
* Immunosenescence
* Macrophages
* Male
* Middle Aged
* Mouth Neoplasms
* Neovascularization, Pathologic
* Receptors, Cell Surface
* Tumor Microenvironment
|keywords=* M1 and M2 macrophages
* angiogenesis
* immunohistochemistry
* immunosenescence
* oral squamous cell carcinoma
|full-text-url=https://sci-hub.do/10.1002/hed.25954
}}
==CD36==
 
{{medline-entry
|title=Liver osteopontin is required to prevent the progression of age-related nonalcoholic fatty liver disease.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32638492
 
 
|keywords=* Osteopontin
* aging
* lipid metabolism
* nonalcoholic fatty liver disease
* p53
* senescence
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7431823
}}
{{medline-entry
|title=Reduction of senescence-associated beta-galactosidase activity by vitamin E in human fibroblasts depends on subjects' age and cell passage number.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32479666
 
 
|keywords=* CD36 scavenger receptor
* alpha-tocopherol
* exosomes
* extracellular vesicles
* gene expression
* lysosome
* senescence
* signal transduction
* vitamin E
|full-text-url=https://sci-hub.do/10.1002/biof.1636
}}
{{medline-entry
|title=Niacin-mediated rejuvenation of macrophage/microglia enhances remyelination of the aging central nervous system.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32030468
 
 
|keywords=* Aging
* Macrophages
* Microglia
* Oligodendrocyte progenitor cells
* Phagocytosis
* Remyelination
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7181452
}}
==CD38==
 
{{medline-entry
|title=Re-equilibration of imbalanced NAD metabolism ameliorates the impact of telomere dysfunction.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32935380
 
 
|keywords=* CD38 NADase
* NAD metabolism
* mitochondrial impairment
* replicative senescence
* telomere biology disorders
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7604620
}}
{{medline-entry
|title=TNFRSF12A and [[CD38]] Contribute to a Vicious Circle for Chronic Obstructive Pulmonary Disease by Engaging Senescence Pathways.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32537452
 
 
|keywords=* aging
* chronic inflammation
* lung
* network analysis
* senescence
* tissue remodeling
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7268922
}}
{{medline-entry
|title=Aging alters acetylation status in skeletal and cardiac muscles.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32300965
 
 
|keywords=* Aging
* CD38
* Deacetylation
* NAD+
* PARP
* SIRT
* Skeletal muscle
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7286993
}}
{{medline-entry
|title=[[CD38]] in Neurodegeneration and Neuroinflammation.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32085567
 
 
|keywords=* ALS.
* Alzheimer’s disease
* CD38
* NAD
* Parkinson’s disease
* aging
* neurodegeneration
* neuroinflammation
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7072759
}}
{{medline-entry
|title=[[CD38]], a Receptor with Multifunctional Activities: From Modulatory Functions on Regulatory Cell Subsets and Extracellular Vesicles, to a Target for Therapeutic Strategies.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31783629
 
|mesh-terms=* ADP-ribosyl Cyclase 1
* Aging
* Animals
* Antibodies, Monoclonal
* B-Lymphocytes, Regulatory
* Cell Line
* Extracellular Vesicles
* Humans
* Infections
* Membrane Glycoproteins
* Mice
* Neoplasms
* T-Lymphocytes, Regulatory
|keywords=* CD38
* adenosine
* immune-modulation
* regulatory cells
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6953043
}}
{{medline-entry
|title=[[CD38]] Deficiency Alleviates D-Galactose-Induced Myocardial Cell Senescence Through NAD /Sirt1 Signaling Pathway.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31551807
 
 
|keywords=* CD38
* D-galactose
* NAD+
* heart senescence
* oxidative stress
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6735286
}}
==CD4==
 
{{medline-entry
|title=Identification of Key Genes and Potential New Biomarkers for Ovarian Aging: A Study Based on RNA-Sequencing Data.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/33304387
 
 
|keywords=* GEO database
* bioinformatics
* biomarker
* immune cell infiltration
* ovarian aging
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7701310
}}
{{medline-entry
|title=Distinct Age-Related Epigenetic Signatures in [[CD4]] and CD8 T Cells.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/33262764
 
 
|keywords=* T-cell
* T-cell homeostasis
* aging
* chromatin accessibility
* epigenetics
* ribosomal proteins
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7686576
}}
{{medline-entry
|title=IL-1β-MyD88-mTOR Axis Promotes Immune-Protective IL-17A Foxp3  Cells During Mucosal Infection and Is Dysregulated With Aging.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/33240286
 
 
|keywords=* Candida
* Foxp3
* IL-1β
* Treg
* Treg17
* aging
* fungal infection
* senescence
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7677307
}}
{{medline-entry
|title=Thymus involution sets the clock of declined immunity and repair with aging.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/33248315
 
 
|keywords=* Aging
* Chronic systemic inflammation
* Dysregulated CD4 T cells
* Immune-mediated repair
* Thymus
|full-text-url=https://sci-hub.do/10.1016/j.arr.2020.101231
}}
{{medline-entry
|title=Food insecurity and T-cell dysregulation in women living with HIV on antiretroviral therapy.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/33247896
 
 
|keywords=* HIV
* exhaustion
* food insecurity
* immune activation
* senescence
|full-text-url=https://sci-hub.do/10.1093/cid/ciaa1771
}}
{{medline-entry
|title=Rapamycin Eyedrops Increased [[CD4]] Foxp3  Cells and Prevented Goblet Cell Loss in the Aged Ocular Surface.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/33255287
 
 
|keywords=* aging
* dry eye
* goblet cell
* inflammation
* lacrimal gland
* ocular surface
* rapamycin
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7727717
}}
{{medline-entry
|title=Antioxidants N-Acetylcysteine and Vitamin C Improve T Cell Commitment to Memory and Long-Term Maintenance of Immunological Memory in Old Mice.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/33228213
 
 
|keywords=* NAC
* T cells
* aging
* antioxidants
* immunosenescence
* vaccination
* vitamin C
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7699597
}}
{{medline-entry
|title=Evolution of comorbidities in people living with HIV between 2004 and 2014: cross-sectional analyses from ANRS CO3 Aquitaine cohort.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/33198667
 
 
|keywords=* Aging
* Cardiovascular events
* Chronic kidney disease
* Comorbidities
* HIV
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7670698
}}
{{medline-entry
|title=Impact of age on [[CD4]] recovery and viral suppression over time among adults living with HIV who initiated antiretroviral therapy in the African Cohort Study.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/33183355
 
 
|keywords=* Elders on antiretroviral drugs
* HIV and aging
* HIV treatment outcomes
* Sub-saharan Africa
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7664082
}}
{{medline-entry
|title=hPMSCs protects against D-galactose-induced oxidative damage of [[CD4]]  T cells through activating Akt-mediated Nrf2 antioxidant signaling.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/33148324
 
 
|keywords=* Aging
* CD4+ T cells
* Nrf2
* Oxidative stress
* Senescence-associated secretoryphenotype
* hPMSC
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7641865
}}
{{medline-entry
|title=Substantial gap in primary care: older adults with HIV presenting late to care.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/33129258
 
 
|keywords=* Aging population
* HIV
* Older adults
* Risk
* Stigma
* Testing
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7603686
}}
{{medline-entry
|title=Quantitative Digitography Measures Fine Motor Disturbances in Chronically Treated HIV Similar to Parkinson's Disease.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/33132893
 
 
|keywords=* HIV—human immunodeficiency virus
* Parkinson’s disease
* aging
* fine motor activities
* motor control
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7575770
}}
{{medline-entry
|title=Monocyte and T Cell Immune Phenotypic Profiles Associated With Age Advancement Differ Between People With HIV, Lifestyle-Comparable Controls and Blood Donors.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/33123168
 
 
|keywords=* HIV
* T cell
* aging
* immune activation
* immune dysfunction
* inflammation
* monocyte
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7573236
}}
{{medline-entry
|title=HIV and three dimensions of Wisdom: Association with cognitive function and physical and mental well-being: For: Psychiatry Research.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/33096437
 
 
|keywords=* Affective
* Aging
* Aids
* Compassion
* Reflective
|full-text-url=https://sci-hub.do/10.1016/j.psychres.2020.113510
}}
{{medline-entry
|title=CD8  T cells are present at low levels in the white matter with physiological and pathological aging.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/33049712
 
 
|keywords=* aging
* neuroscience
* pathology
|full-text-url=https://sci-hub.do/10.18632/aging.104043
}}
{{medline-entry
|title=Immunotherapy in older patients with cancer.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/33041248
 
 
|keywords=* Ageing
* Cancer
* Elderly
* Immunosenescence
* Immunotherapy
* Old people
* Oncogeriatry
|full-text-url=https://sci-hub.do/10.1016/j.bj.2020.07.009
}}
{{medline-entry
|title=Multiple genetic programs contribute to [[CD4]] T cell memory differentiation and longevity by maintaining T cell quiescence.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32987276
 
 
|keywords=* CD4 T cell
* Cell longevity
* Gene
* Genetic programs
* Memory T cell
* Memory cell markers
|full-text-url=https://sci-hub.do/10.1016/j.cellimm.2020.104210
}}
{{medline-entry
|title=Conventional Treatment for Multiple Myeloma Drives Premature Aging Phenotypes and Metabolic Dysfunction in T Cells.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/33013907
 
 
|keywords=* T cell
* aging
* autologous stem cell transplant
* metabolism
* myeloma
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7494758
}}
{{medline-entry
|title=Immunosenescence: the role of age in multiple sclerosis.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32962809
 
 
|keywords=* Ageing
* Envejecimiento
* Esclerosis múltiple
* Esclerosis múltiple de comienzo tardío
* Immunosenescence
* Inmunosenescencia
* Late-onset multiple sclerosis
* Multiple sclerosis
|full-text-url=https://sci-hub.do/10.1016/j.nrl.2020.05.016
}}
{{medline-entry
|title=Umbilical cord mesenchymal stem cells protect thymus structure and function in aged C57 mice by downregulating aging-related genes and upregulating autophagy- and anti-oxidative stress-related genes.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32924972
 
 
|keywords=* aged
* senescence
* thymus
* transplantation
* umbilical cord mesenchymal stem cells
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7521525
}}
{{medline-entry
|title=Impaired Cytotoxic CD8  T Cell Response in Elderly COVID-19 Patients.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32948688
 
|mesh-terms=* Aged, 80 and over
* Antigens, CD
* Betacoronavirus
* CD4-Positive T-Lymphocytes
* CD8-Positive T-Lymphocytes
* COVID-19
* Coronavirus Infections
* Cytotoxins
* Female
* Humans
* Immunity, Cellular
* Male
* Middle Aged
* Pandemics
* Pneumonia, Viral
* SARS-CoV-2
* T-Lymphocyte Subsets
* T-Lymphocytes, Cytotoxic
|keywords=* CD4+
 
* CD8+
 
* COVID-19
* PD-1
* SARS-CoV-2
* aging
* cytotoxic T cells
* granzyme
* perforin
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7502863
}}
{{medline-entry
|title=What are the roles of antibodies versus a durable, high quality T-cell response in protective immunity against SARS-CoV-2?
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32875286
 
 
|keywords=* Antibodies
* Antibody-dependent enhancement
* CD8 T-cells
* COVID-19
* Durable immunity
* Protective immunity
* SARS
* SARS-CoV-2
* T cell lifespan
* T-cell epitopes
* T-cells
* Vaccines
* Yellow Fever Vaccine
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7452821
}}
{{medline-entry
|title=Per2 Upregulation in Circulating Hematopoietic Progenitor Cells During Chronic HIV Infection.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32850472
 
 
|keywords=* HIV
* Sirtuin 1
* hematopoietic progenitor cells
* period circadian clock 2
* senescence
* telomere length
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7396677
}}
{{medline-entry
|title=COVID-19: age, Interleukin-6, C-reactive protein, and lymphocytes as key clues from a multicentre retrospective study.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32802142
 
 
|keywords=* ACE2
* C-reactive protein
* COVID-19
* Immunity
* Immunosenescence
* Interleukin-6
* Lymphocytes
* Renin-angiotensin system
* Severe acute respiratory syndrome coronavirus 2
* Spain
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7426672
}}
{{medline-entry
|title=Immunosenescence profiles are not associated with muscle strength, physical performance and sarcopenia risk in very old adults: The Newcastle 85+ Study.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32735896
 
 
|keywords=* immunosenescence
* lymphocyte compartments
* physical performance
* sarcopenia
* very old adults
|full-text-url=https://sci-hub.do/10.1016/j.mad.2020.111321
}}
{{medline-entry
|title=Homeostasis and the functional roles of [[CD4]]  Treg cells in aging.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32717201
 
 
|keywords=* Aging
* Autoimmunity
* Cancer
* FOXP3
* Immune senescence
* Immune suppression
* Inflammaging
* Regulatory T cells
* T helper 17
* Treg
|full-text-url=https://sci-hub.do/10.1016/j.imlet.2020.07.004
}}
{{medline-entry
|title=A Comprehensive Evaluation of the Impact of Bovine Milk Containing Different Beta-Casein Profiles on Gut Health of Ageing Mice.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32707687
 
 
|keywords=* A2 beta-casein
* SCFAs
* elderly
* gut inflammation
* gut microbiota
* gut morphology
* immunosenescence
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7400800
}}
{{medline-entry
|title=Premature aging of circulating T cells predicts all-cause mortality in hemodialysis patients.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32660510
 
 
|keywords=* Hemodialysis
* Inflammation
* Mortality
* T cell aging
* naïve T cells
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7359274
}}
{{medline-entry
|title=In-depth immune cellular profiling reveals sex-specific associations with frailty.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32582361
 
 
|keywords=* Frailty
* Healthy aging
* Immune cellular profiling
* Immune homeostasis
* Immunosenescence
* Sex-specific immune profile
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7310472
}}
{{medline-entry
|title=CD70 contributes to age-associated T cell defects and overwhelming inflammatory responses.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32559178
 
 
|keywords=* CD70
* T cell aging
* co-inhibitory molecules
* immunosenescence
* overwhelming inflammatory responses
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7343466
}}
{{medline-entry
|title=Comparison of Overall and Comorbidity-Free Life Expectancy Between Insured Adults With and Without HIV Infection, 2000-2016.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32539152
 
|mesh-terms=* Adult
* Chronic Disease
* Cohort Studies
* Comorbidity
* Female
* HIV Infections
* Humans
* Insurance, Health
* Life Expectancy
* Male
* Middle Aged
 
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7296391
}}
{{medline-entry
|title=Comparative Analysis of Age-Related Changes in Lacrimal Glands and Meibomian Glands of a C57BL/6 Male Mouse Model.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32545199
 
 
|keywords=* aging
* dry eye
* inflammation
* lacrimal glands
* meibomian glands
* oxidative stress
* senescence
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7313015
}}
{{medline-entry
|title=Thymus aging in mice deficient in either EphB2 or EphB3, two master regulators of thymic epithelium development.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32506584
 
 
|keywords=* senescence
* thymic epithelial cells
* thymocytes
|full-text-url=https://sci-hub.do/10.1002/dvdy.212
}}
{{medline-entry
|title=CD8  T-cell senescence and skewed lymphocyte subsets in young Dyskeratosis Congenita patients with PARN and DKC1 mutations.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32452087
 
 
|keywords=*
DKC1
 
*
PARN
 
* Dyskeratosis Congenita
* primary immunodeficiency
* senescence
* telomere
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7521304
}}
{{medline-entry
|title=Short-Term Environmental Enrichment is a Stronger Modulator of Brain Glial Cells and Cervical Lymph Node T Cell Subtypes than Exercise or Combined Exercise and Enrichment.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32451728
 
 
|keywords=* Aging
* Astrocytes
* Environmental enrichment
* Microglia
* Physical exercise
* T cells
|full-text-url=https://sci-hub.do/10.1007/s10571-020-00862-x
}}
{{medline-entry
|title=Viral and host factors related to the clinical outcome of COVID-19.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32434211
 
|mesh-terms=* Adolescent
* Adult
* Aged
* Aged, 80 and over
* Aging
* Animals
* Asymptomatic Infections
* Betacoronavirus
* COVID-19
* China
* Cohort Studies
* Coronavirus Infections
* Critical Illness
* Disease Progression
* Evolution, Molecular
* Female
* Genetic Variation
* Genome, Viral
* Hospitalization
* Host-Pathogen Interactions
* Humans
* Inflammation Mediators
* Interleukin-6
* Interleukin-8
* Lymphocyte Count
* Lymphopenia
* Male
* Middle Aged
* Pandemics
* Phylogeny
* Pneumonia, Viral
* Respiratory Distress Syndrome
* SARS-CoV-2
* T-Lymphocytes
* Time Factors
* Treatment Outcome
* Virulence
* Virus Shedding
* Young Adult
* Zoonoses
 
|full-text-url=https://sci-hub.do/10.1038/s41586-020-2355-0
}}
{{medline-entry
|title=Use of comedications and potential drug-drug interactions in people living with HIV in China.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32354599
 
 
|keywords=* Aging
* China
* Co-medication
* Drug-drug interaction
* HIV
|full-text-url=https://sci-hub.do/10.1016/j.jiac.2020.04.003
}}
{{medline-entry
|title=[[CD4]]  T helper 17 cell response of aged mice promotes prostate cancer cell migration and invasion.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32356608
 
|mesh-terms=* Aging
* Animals
* CD4-Positive T-Lymphocytes
* Cell Differentiation
* Cell Line, Tumor
* Cell Movement
* Humans
* Inflammation
* Male
* Mice
* Mice, Inbred C57BL
* Mice, Knockout
* Models, Animal
* NF-kappa B
* Neoplasm Invasiveness
* PC-3 Cells
* Prostatic Neoplasms
* Th17 Cells
|keywords=* CD4+ T cell-secreted factors
* PCa cells
* Th17 cytokines
* aging
* inflammation
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7310589
}}
{{medline-entry
|title=The Rules of Human T Cell Fate [i]in vivo[/i].
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32322253
 
 
|keywords=* decision
* fate
* half-life
* labeling
* lifespan
* lymphocyte
* mathematical model
* proliferation
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7156550
}}
{{medline-entry
|title=[[CD4]]/CD8 ratio, comorbidities, and aging in treated HIV infected individuals on viral suppression.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32314818
 
 
|keywords=* CD4/CD8 ratio
* HIV
* aging
* comorbidities
|full-text-url=https://sci-hub.do/10.1002/jmv.25911
}}
{{medline-entry
|title=The effects of advanced maternal age on T-cell subsets at the maternal-fetal interface prior to term labor and in the offspring: a mouse study.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32279324
 
|mesh-terms=* Adult
* Aging
* Animals
* Female
* Humans
* Live Birth
* Mice
* Mice, Transgenic
* Placenta
* Pregnancy
* T-Lymphocyte Subsets
|keywords=* birth weight
* neonate
* offspring
* pregnancy
* preterm labor
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7290081
}}
{{medline-entry
|title=Structural and Functional Changes in the Mesenteric Lymph Nodes in Humans during Aging.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32248450
 
 
|keywords=* age-related involution
* aging
* immune system
* immunomorphology
* mesenteric lymph nodes
|full-text-url=https://sci-hub.do/10.1007/s10517-020-04782-0
}}
{{medline-entry
|title=Neurocognitive Functioning is Associated with Self-Reported and Performance-Based Treatment Management Abilities in People Living with HIV with Low Health Literacy.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32090235
 
|mesh-terms=* Adult
* Cognition
* Cross-Sectional Studies
* HIV Infections
* Health Literacy
* Humans
* Neuropsychological Tests
* Self Report
|keywords=* Adherence
* Aging
* Cognitive impairment
* HIV/AIDS
* Health illiteracy
* Observational study
|full-text-url=https://sci-hub.do/10.1093/arclin/acaa005
}}
{{medline-entry
|title=Blockade of Stat3 oncogene addiction induces cellular senescence and reveals a cell-nonautonomous activity suitable for cancer immunotherapy.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32064174
 
 
|keywords=* Stat3
* immune checkpoint blockade
* immunotherapy
* oncogene addiction
* senescence
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6996562
}}
{{medline-entry
|title=Age-related changes in T lymphocytes of patients with head and neck squamous cell carcinoma.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32082401
 
 
|keywords=* Aging
* Head and neck cancer
* Immune escape
* Immunosenescence
* T cells
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7017629
}}
{{medline-entry
|title=Immunological history governs human stem cell memory [[CD4]] heterogeneity via the Wnt signaling pathway.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32041953
 
|mesh-terms=* Aging
* Animals
* Antigens, CD
* CD4-Positive T-Lymphocytes
* Gene Expression Profiling
* HIV Infections
* Humans
* Immunologic Memory
* Intercellular Signaling Peptides and Proteins
* Mice
* Precursor Cells, T-Lymphoid
* Thymus Gland
* Wnt Signaling Pathway
* beta Catenin
 
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7010798
}}
{{medline-entry
|title=Estimating HIV Management and Comorbidity Costs Among Aging HIV Patients in the United States: A Systematic Review.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32011956
 
|mesh-terms=* Anti-HIV Agents
* CD4 Lymphocyte Count
* Comorbidity
* Cost-Benefit Analysis
* HIV Infections
* Health Care Costs
* Humans
* Life Expectancy
* United States
 
|full-text-url=https://sci-hub.do/10.18553/jmcp.2020.26.2.104
}}
{{medline-entry
|title=Sex Differences in People Aging With HIV.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32032279
 
|mesh-terms=* Aged
* Aging
* Alcohol Drinking
* Body Composition
* CD4 Lymphocyte Count
* CD4-CD8 Ratio
* CD4-Positive T-Lymphocytes
* Cohort Studies
* Cross-Sectional Studies
* Female
* Frailty
* HIV Infections
* Humans
* Male
* Middle Aged
* Muscle Strength
* Prospective Studies
 
|full-text-url=https://sci-hub.do/10.1097/QAI.0000000000002259
}}
{{medline-entry
|title=Identification of Differentially Expressed miRNAs in the Response of Spleen [[CD4]]  T Cells to Electroacupuncture in Senescence-Accelerated Mice.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32026263
 
|mesh-terms=* Aging
* Animals
* Antagomirs
* CD4-Positive T-Lymphocytes
* Cell Differentiation
* Cytokines
* Down-Regulation
* Electroacupuncture
* Female
* Gene Regulatory Networks
* High-Throughput Nucleotide Sequencing
* Male
* Mice
* Mice, Inbred C57BL
* MicroRNAs
* Sequence Analysis, RNA
* Spleen
* Up-Regulation
|keywords=* CD4+ T cell
* Deep sequencing
* Electroacupuncture
* Immunological aging
* miRNA
|full-text-url=https://sci-hub.do/10.1007/s12013-020-00900-x
}}
{{medline-entry
|title=Thymus Involution and Intravenous Drug Abuse.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32000220
 
|mesh-terms=* Adolescent
* Adult
* Aging
* Atrophy
* CD4-Positive T-Lymphocytes
* CD8-Positive T-Lymphocytes
* Calcinosis
* Case-Control Studies
* Drug Users
* Female
* Forensic Pathology
* Hepatitis C, Chronic
* Humans
* Male
* Middle Aged
* Substance Abuse, Intravenous
* Thymus Gland
* Young Adult
 
|full-text-url=https://sci-hub.do/10.1097/PAF.0000000000000530
}}
{{medline-entry
|title=Depletion of [[CD4]] T cells provides therapeutic benefits in aged mice after ischemic stroke.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31954116
 
|mesh-terms=* Aging
* Animals
* Behavior, Animal
* Brain Chemistry
* Brain Ischemia
* CD4-Positive T-Lymphocytes
* Chemokines
* Cytokines
* Female
* Infarction, Middle Cerebral Artery
* Inflammation
* Male
* Mice
* Mice, Inbred C57BL
* Stroke
* Treatment Outcome
|keywords=* Age
* CD4 T cells
* CXCL10
* Inflammation
* Stroke
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7059209
}}
{{medline-entry
|title=Immunological and Virological Responses in Older HIV-Infected Adults Receiving Antiretroviral Therapy: An Evidence-Based Meta-Analysis.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31913990
 
|mesh-terms=* Aged
* Aging
* Anti-HIV Agents
* HIV Infections
* Humans
* Middle Aged
 
|full-text-url=https://sci-hub.do/10.1097/QAI.0000000000002266
}}
{{medline-entry
|title=African Mitochondrial DNA Haplogroup L2 Is Associated With Slower Decline of β-cell Function and Lower Incidence of Diabetes Mellitus in Non-Hispanic, Black Women Living With Human Immunodeficiency Virus.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31927570
 
 
|keywords=* HIV
* aging
* diabetes mellitus
* mitochondrial genetics
|full-text-url=https://sci-hub.do/10.1093/cid/ciaa026
}}
{{medline-entry
|title=DP1 Activation Reverses Age-Related Hypertension Via NEDD4L-Mediated T-Bet Degradation in T Cells.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31893939
 
|mesh-terms=* Aged
* Aging
* Animals
* Antihypertensive Agents
* CD4-Positive T-Lymphocytes
* Cyclic AMP-Dependent Protein Kinases
* Cytokines
* Humans
* Hypertension
* Mice
* Mice, Inbred C57BL
* Nedd4 Ubiquitin Protein Ligases
* Prostaglandin D2
* Receptors, Prostaglandin
* Signal Transduction
* Sp1 Transcription Factor
* Superoxides
* T-Box Domain Proteins
* Th1 Cells
* Ubiquitination
|keywords=* D-prostanoid receptor 1
* aging
* hypertension
* lymphocyte
* prostaglandin (PG) D2
|full-text-url=https://sci-hub.do/10.1161/CIRCULATIONAHA.119.042532
}}
{{medline-entry
|title=An Emerging Concern-High Rates of Frailty among Middle-aged and Older Individuals Living with HIV.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31885759
 
 
|keywords=* accelerated aging
* anti-retroviral therapy
* frailty
* frailty index
* geriatric syndrome
* human immunodeficiency virus (HIV)
* multimorbidity
* vulnerability
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6887139
}}
{{medline-entry
|title=Higher Acuity Resource Utilization With Older Age and Poorer HIV Control in Adolescents and Young Adults in the HIV Research Network.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31904706
 
|mesh-terms=* Adolescent
* Adult
* Aging
* Anti-Retroviral Agents
* CD4 Lymphocyte Count
* Drug Administration Schedule
* Female
* HIV Infections
* HIV-1
* Humans
* Male
* Medication Adherence
* Viral Load
* Young Adult
 
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7055514
}}
{{medline-entry
|title=Mitochondrial DNA Haplogroups and Frailty in Adults Living with HIV.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31822125
 
 
|keywords=* HIV
* aging
* frailty
* haplotypes
* mitochondria
* sarcopenia
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7133433
}}
{{medline-entry
|title=Gallic acid attenuates thymic involution in the d-galactose induced accelerated aging mice.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31822433
 
 
|keywords=* Aging
* FoxN1
* Gallic acid
* Thymus
* d-galactose
|full-text-url=https://sci-hub.do/10.1016/j.imbio.2019.11.005
}}
{{medline-entry
|title=Mitochondrial mass governs the extent of human T cell senescence.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31788930
 
|mesh-terms=* Adenosine Triphosphate
* Adult
* CD4-Positive T-Lymphocytes
* CD8-Positive T-Lymphocytes
* Cell Movement
* Cell Proliferation
* Cellular Senescence
* Glucose
* Glycolysis
* Humans
* Immunosenescence
* Leukocyte Common Antigens
* Microscopy, Electron, Transmission
* Middle Aged
* Mitochondria
* Rotenone
|keywords=* T cell
* aging
* metabolism
* mitochondria
* senescence
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6996952
}}
{{medline-entry
|title=T cells and immune functions of plasma extracellular vesicles are differentially modulated from adults to centenarians.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31785146
 
|mesh-terms=* Adult
* Aged
* Aged, 80 and over
* Extracellular Vesicles
* Female
* Humans
* Immunosenescence
* Lymphocyte Activation
* Male
* Middle Aged
* T-Lymphocytes
|keywords=* T cells
* aging
* centenarians
* extracellular vesicles (EVs)
* immunosenescence
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6914389
}}
{{medline-entry
|title=Defects in Antiviral T Cell Responses Inflicted by Aging-Associated miR-181a Deficiency.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31747595
 
|mesh-terms=* Aging
* Animals
* CD4-Positive T-Lymphocytes
* CD8-Positive T-Lymphocytes
* Disease Models, Animal
* Lymphocytic Choriomeningitis
* Lymphocytic choriomeningitis virus
* Mice
* MicroRNAs
|keywords=* CD8 effector T cell
* T cell repertoire
* antiviral response
* immune aging
* immunosenescence
* microRNA
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6957231
}}
{{medline-entry
|title=Increased Prevalence of Neurocognitive Impairment in Aging People Living With Human Immunodeficiency Virus: The ANRS EP58 HAND 55-70 Study.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31755936
 
 
|keywords=* Frascati criteria
* HAND
* HIV
* aging
* neurocognitive impairment
|full-text-url=https://sci-hub.do/10.1093/cid/ciz670
}}
{{medline-entry
|title=Age-associated changes in human [[CD4]]  T cells point to mitochondrial dysfunction consequent to impaired autophagy.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31707363
 
|mesh-terms=* Adult
* Aged
* CD4-Positive T-Lymphocytes
* Cell Respiration
* Humans
* Immunosenescence
* Longitudinal Studies
* Mitochondria
* Mitophagy
* Young Adult
|keywords=* CD4+ T cells
* aging
* autophagy
* mitochondria
* proteomics
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6874450
}}
{{medline-entry
|title=Sex Differences in the Blood Transcriptome Identify Robust Changes in Immune Cell Proportions with Aging and Influenza Infection.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31722210
 
|mesh-terms=* Aging
* CD4-Positive T-Lymphocytes
* Female
* Humans
* Influenza, Human
* Male
* Monocytes
* Sex Characteristics
* Transcriptome
|keywords=* CD4(+) T cells
* aging
* immune system
* immunology
* influenza
* meta-analysis
* monocytes
* multi-cohort analysis
* sex differences
* transcriptome
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6856718
}}
{{medline-entry
|title=Going Beyond Giving Antiretroviral Therapy: Multimorbidity in Older People Aging with HIV in Nigeria.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31711310
 
 
|keywords=* ART
* PLWH
* aging
* multimorbidity
* quality of life
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7071065
}}
{{medline-entry
|title=Alterations in composition of immune cells and impairment of anti-tumor immune response in aged oral cancer-bearing mice.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31683168
 
|mesh-terms=* Aged
* Animals
* Cell Line, Tumor
* Cell Proliferation
* Female
* Humans
* Immunotherapy
* Mice
|keywords=* Aging
* Immune check-point molecules
* Immunosenescence
* Immunotherapy
* Myeloid derived suppressor cells
* Oral cancer
* Regulatory T cells
|full-text-url=https://sci-hub.do/10.1016/j.oraloncology.2019.104462
}}
{{medline-entry
|title=LTA1 is a safe, intranasal enterotoxin-based adjuvant that improves vaccine protection against influenza in young, old and B-cell-depleted (μMT) mice.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31641151
 
|mesh-terms=* Adjuvants, Immunologic
* Administration, Intranasal
* Aging
* Animals
* Antibodies
* Antibody Formation
* B-Lymphocytes
* CD4-Positive T-Lymphocytes
* Dose-Response Relationship, Immunologic
* Enterotoxins
* Female
* Immunity, Mucosal
* Immunization
* Inflammation
* Influenza A Virus, H1N1 Subtype
* Lung
* Lymphocyte Activation
* Lymphocyte Depletion
* Mast Cells
* Mice, Inbred C57BL
* Orthomyxoviridae Infections
 
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6805908
}}
{{medline-entry
|title=Thymus Imaging Detection and Size Is Inversely Associated With Metabolic Syndrome and Frailty in People With HIV.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31660382
 
 
|keywords=* HIV
* aging
* frailty
* metabolic syndrome
* thymus
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6809752
}}
{{medline-entry
|title=Alterations in peripheral T cell and B cell subsets in patients with osteoarthritis.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31624962
 
|mesh-terms=* Aged
* Aging
* B-Lymphocyte Subsets
* Case-Control Studies
* Female
* Humans
* Male
* Middle Aged
* Osteoarthritis, Knee
* T-Lymphocyte Subsets
|keywords=* B cell
* Lymphocyte
* Osteoarthritis
* T cell
|full-text-url=https://sci-hub.do/10.1007/s10067-019-04768-y
}}
{{medline-entry
|title=Short Communication: Carotid Intima-Media Thickness Is Not Associated with Neurocognitive Impairment Among People Older than 50 Years With and Without HIV Infection from Thailand.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31588776
 
|mesh-terms=* Aging
* Anti-Retroviral Agents
* Cardiovascular Diseases
* Carotid Intima-Media Thickness
* Cross-Sectional Studies
* Depression
* Female
* HIV Infections
* Humans
* Male
* Middle Aged
* Neurocognitive Disorders
* Quality of Life
* Risk Factors
* Thailand
|keywords=* HIV
* aging
* carotid intima-media thickness
* neurocognitive
|full-text-url=https://sci-hub.do/10.1089/AID.2019.0139
}}
{{medline-entry
|title=Implications of Immune Checkpoint Expression During Aging in HIV-Infected People on Antiretroviral Therapy.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31578868
 
|mesh-terms=* Adult
* Aged
* Aging
* Anti-HIV Agents
* Antiretroviral Therapy, Highly Active
* CD4-Positive T-Lymphocytes
* CD8-Positive T-Lymphocytes
* Cytokines
* Female
* Flow Cytometry
* Gene Expression
* HIV Infections
* HIV-1
* Hepatitis A Virus Cellular Receptor 2
* Humans
* Leukocytes, Mononuclear
* Male
* Middle Aged
* Young Adult
* gag Gene Products, Human Immunodeficiency Virus
|keywords=* aging
* immune checkpoint molecules
* virus suppression
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6862963
}}
{{medline-entry
|title=Age-related alterations in human gut [[CD4]] T cell phenotype, T helper cell frequencies, and functional responses to enteric bacteria.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31573727
 
|mesh-terms=* Adolescent
* Adult
* Age Factors
* Aged
* Aged, 80 and over
* CD4-Positive T-Lymphocytes
* Female
* Gastrointestinal Microbiome
* Humans
* Interleukin-17
* Intestinal Mucosa
* Male
* Middle Aged
* Phenotype
* Th1 Cells
* Th17 Cells
* Young Adult
|keywords=* T helper cells
* aging
* gut
* human
|full-text-url=https://sci-hub.do/10.1002/JLB.5A0919-177RR
}}
{{medline-entry
|title=Determinants of blood telomere length in antiretroviral treatment-naïve HIV-positive participants enrolled in the NEAT 001/ANRS 143 clinical trial.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31532902
 
|mesh-terms=* Adult
* Aged
* Anti-Retroviral Agents
* Cross-Sectional Studies
* Darunavir
* Emtricitabine
* Female
* HIV Infections
* Humans
* Logistic Models
* Male
* Middle Aged
* RNA, Viral
* Raltegravir Potassium
* Ritonavir
* Telomere
* Tenofovir
|keywords=* HIV infection
* aging
* immunosenescence
* telomere length
* viral load
|full-text-url=https://sci-hub.do/10.1111/hiv.12791
}}
{{medline-entry
|title=Human T Cell Differentiation Negatively Regulates Telomerase Expression Resulting in Reduced Activation-Induced Proliferation and Survival.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31497023
 
|mesh-terms=* Adult
* Cell Differentiation
* Cell Proliferation
* Cell Survival
* Humans
* T-Lymphocytes
* Telomerase
|keywords=* T cell subsets
* T lymphocytes
* aging
* alternative splicing
* differentiation
* hTERT
* proliferation
* telomerase
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6712505
}}
{{medline-entry
|title=Short Communication: Getting Older with HIV: Increasing Frequency of Comorbidities and Polypharmacy in Brazilian HIV Patients.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31452382
 
|mesh-terms=* Aged
* Aging
* Brazil
* CD4 Lymphocyte Count
* Cardiovascular Diseases
* Comorbidity
* Diabetes Mellitus
* Female
* HIV Infections
* Humans
* Life Expectancy
* Male
* Middle Aged
* Neoplasms
* Polypharmacy
|keywords=* Brazil
* HIV
* aging
* noncommunicable diseases
|full-text-url=https://sci-hub.do/10.1089/AID.2019.0069
}}
{{medline-entry
|title=Gait Speed Decline Is Associated with Hemoglobin A1C, Neurocognitive Impairment, and Black Race in Persons with HIV.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31468979
 
|mesh-terms=* Adult
* African Americans
* Aging
* CD4 Lymphocyte Count
* Cohort Studies
* Female
* Glycated Hemoglobin A
* HIV Infections
* Humans
* Longitudinal Studies
* Male
* Middle Aged
* Neurocognitive Disorders
* Odds Ratio
* RNA, Viral
* Risk Factors
* Walking Speed
|keywords=* aging
* gait speed
* hemoglobin A1C
* neurocognitive impairment
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6862955
}}
{{medline-entry
|title=Noncommunicable Diseases Burden and Risk Factors in a Cohort of HIV+ Elderly Patients in Malawi.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31468993
 
|mesh-terms=* Adult
* Age Factors
* Aged
* Anti-HIV Agents
* Anti-Retroviral Agents
* CD4 Lymphocyte Count
* Comorbidity
* Cost of Illness
* Cross-Sectional Studies
* Diabetes Mellitus
* Female
* HIV Infections
* Humans
* Hypertension
* Malawi
* Male
* Middle Aged
* Noncommunicable Diseases
* Odds Ratio
* Prevalence
* Retrospective Studies
* Risk Factors
|keywords=* HIV infection
* Malawi
* aging
* noncommunicable diseases
|full-text-url=https://sci-hub.do/10.1089/AID.2019.0125
}}
{{medline-entry
|title=Aging promotes reorganization of the [[CD4]] T cell landscape toward extreme regulatory and effector phenotypes.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31457092
 
|mesh-terms=* Aging
* Animals
* CD4-Positive T-Lymphocytes
* High-Throughput Nucleotide Sequencing
* Immunomodulation
* Mice
* Phenotype
* Sequence Analysis, RNA
* Single-Cell Analysis
* T-Lymphocyte Subsets
 
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6703865
}}
{{medline-entry
|title=Prevalence of hypertension and cardiovascular risk factors among long-term AIDS survivors: A report from the field.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31448551
 
|mesh-terms=* Acquired Immunodeficiency Syndrome
* Adult
* Anti-Retroviral Agents
* CD4 Lymphocyte Count
* Cardiovascular Diseases
* Diabetes Mellitus
* Diagnostic Screening Programs
* Female
* HIV Infections
* HIV-1
* Haiti
* Humans
* Hypercholesterolemia
* Hypertension
* Male
* Middle Aged
* Obesity
* Prevalence
* Retrospective Studies
* Risk Factors
* Smoking
* Survivors
|keywords=* HIV
* aging
* cardiovascular disease
* hypertension
* risk assessment
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6896990
}}
==CD44==
 
{{medline-entry
|title=Hyaluronan goes to great length.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32908962
 
 
|keywords=* aging
* hyaluronan
* longevity
* naked mole rat
* very high molecular weight hyaluronan
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7453635
}}
{{medline-entry
|title=Naked mole-rat very-high-molecular-mass hyaluronan exhibits superior cytoprotective properties.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32398747
 
|mesh-terms=* Animals
* Apoptosis
* Cell Cycle Checkpoints
* Cell Line
* Cytoprotection
* Gene Expression Regulation
* Gene Knockout Techniques
* Humans
* Hyaluronan Receptors
* Hyaluronic Acid
* Longevity
* Mice
* Mole Rats
* Molecular Weight
* Primary Cell Culture
* Protein Interaction Maps
* RNA-Seq
* Signal Transduction
* Species Specificity
* Stress, Physiological
* Tumor Suppressor Protein p53
 
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7217962
}}
{{medline-entry
|title=Maturity-dependent cartilage cell plasticity and sensitivity to external perturbation.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32321631
 
 
|keywords=* Aging
* Articular cartilage
* Osteoarthritis
* Plasticity
* Progenitor cells
|full-text-url=https://sci-hub.do/10.1016/j.jmbbm.2020.103732
}}
{{medline-entry
|title=Aged Mice Exhibit Severe Exacerbations of Dry Eye Disease with an Amplified Memory Th17 Cell Response.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32289288
 
|mesh-terms=* Aging
* Animals
* Dry Eye Syndromes
* Female
* Immunologic Memory
* Mice
* Mice, Inbred C57BL
* Th17 Cells
 
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7369573
}}
{{medline-entry
|title=Chronic circadian misalignment accelerates immune senescence and abbreviates lifespan in mice.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32054990
 
|mesh-terms=* Animals
* B-Lymphocytes
* Cellular Senescence
* Circadian Rhythm
* Disease Models, Animal
* Humans
* Hyaluronan Receptors
* Inflammation
* Jet Lag Syndrome
* Longevity
* Mice
* Programmed Cell Death 1 Receptor
* Sequence Analysis, RNA
* T-Lymphocytes
 
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7018741
}}
{{medline-entry
|title=Defective induction of the proteasome associated with T-cell receptor signaling underlies T-cell senescence.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31621149
 
|mesh-terms=* Animals
* CD4-Positive T-Lymphocytes
* Cell Proliferation
* Cells, Cultured
* Cellular Senescence
* Cytokines
* Hyaluronan Receptors
* Mice
* Mice, Inbred C57BL
* Phenotype
* Programmed Cell Death 1 Receptor
* Proteasome Endopeptidase Complex
* Receptors, Antigen, T-Cell
* Signal Transduction
|keywords=* T cell receptor signal
* T cell senescence
* aging
* proteasome
|full-text-url=https://sci-hub.do/10.1111/gtc.12728
}}
==CD47==
 
{{medline-entry
|title=Aging-associated changes in [[CD47]] arrangement and interaction with thrombospondin-1 on red blood cells visualized by super-resolution imaging.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32866348
 
 
|keywords=* CD47
* aging
* dSTORM
* red blood cells
* thrombospondin-1
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7576236
}}
{{medline-entry
|title=[[CD47]] Promotes Age-Associated Deterioration in Angiogenesis, Blood Flow and Glucose Homeostasis.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32679764
 
 
|keywords=* CD47
* aging
* angiogenesis
* blood flow
* endothelial cells
* glucose homeostasis
* metabolism
* self-renewal
* thrombospondin-1
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7407670
}}
{{medline-entry
|title=Unique Spatial Immune Profiling in Pancreatic Ductal Adenocarcinoma with Enrichment of Exhausted and Senescent T Cells and Diffused [[CD47]]-SIRPα Expression.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32645996
 
 
|keywords=* CD47
* T cell exhaustion
* T cell senescence
* draining lymph nodes
* macrophage checkpoint
* neoadjuvant chemotherapy
* pancreatic ductal adenocarcinoma
* signal regulatory protein alpha (SIRPα)
* spatial heterogeneity
* tumor microenvironment
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7408661
}}
==CD5==
 
{{medline-entry
|title=Comparative proteomic analysis identifies biomarkers for renal aging.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/33159023
 
 
|keywords=* NMN
* biomarkers
* glutathionylation
* proteomics
* renal aging
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7695359
}}
==CD63==
 
{{medline-entry
|title=Cellular senescence contributes to age-dependent changes in circulating extracellular vesicle cargo and function.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31960578
 
 
|keywords=* aging
* extracellular vesicles
* microRNA
* plasma
* senescence
* senolytic
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7059145
}}
==CD68==
 
{{medline-entry
|title=Insulin activates microglia and increases COX-2/IL-1β expression in young but not in aged hippocampus.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32422127
 
 
|keywords=* Aging
* Hippocampus
* Insulin
* Memory
* Microglia
* Neuroinflammation
|full-text-url=https://sci-hub.do/10.1016/j.brainres.2020.146884
}}
{{medline-entry
|title=Epigenetic modulation of macrophage polarization prevents lumbar disc degeneration.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32310825
 
 
|keywords=* DNA methyltransferase 1 (DNMT1)
* aging
* lumbar disc degeneration (LDD)
* macrophage polarization
* transforming growth factor beta 1 (TGFβ1)
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7202517
}}
{{medline-entry
|title=Cellular senescence in recurrent tonsillitis and tonsillar hypertrophy in children.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32200310
 
|mesh-terms=* Antigens, CD
* Antigens, Differentiation, Myelomonocytic
* Cellular Senescence
* Child
* Germinal Center
* Humans
* Hypertrophy
* Macrophages
* Palatine Tonsil
* Recurrence
* Tonsillectomy
* Tonsillitis
|keywords=* Cellular senescence
* Recurrent tonsillitis
* Tonsillar hypertrophy
|full-text-url=https://sci-hub.do/10.1016/j.ijporl.2020.110004
}}
{{medline-entry
|title=Ginsenoside Rg1 supplementation clears senescence-associated β-galactosidase in exercising human skeletal muscle.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31695564
 
 
|keywords=* Cellular senescence
* Endurance
* Ergogenic aid
* Inflammation
* Macrophage
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6823780
}}
{{medline-entry
|title=Histopathological, immunohistochemical, and molecular studies for determination of wound age and vitality in rats.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31448552
 
|mesh-terms=* Actins
* Animals
* Antigens, CD
* Antigens, Differentiation, Myelomonocytic
* Cell Movement
* Fibroblasts
* Granulation Tissue
* Immunohistochemistry
* Macrophages
* Models, Animal
* Neovascularization, Physiologic
* RNA, Messenger
* Rats, Wistar
* Re-Epithelialization
* Skin
* Time Factors
* Transforming Growth Factor beta1
* Vascular Endothelial Growth Factor A
* Wound Healing
* Wounds and Injuries
|keywords=* TGFb1
* VEGF
* gene expression
* immunohistochemistry
* wound aging
|full-text-url=https://sci-hub.do/10.1111/iwj.13206
}}
==CD80==
 
{{medline-entry
|title=The aging common marmoset's immune system: From junior to senior.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32246726
 
|mesh-terms=* Aging
* Animals
* CD4-CD8 Ratio
* Callithrix
* Female
* Flow Cytometry
* Immune System
* Longevity
* Male
* Models, Animal
* Sex Factors
|keywords=* aging
* common marmoset
* immune system
* immunosenescence
* innate and adaptive immunity
* sex
|full-text-url=https://sci-hub.do/10.1002/ajp.23128
}}
==CD81==
 
{{medline-entry
|title=Ovarian aging increases small extracellular vesicle [[CD81]]  release in human follicular fluid and influences miRNA profiles.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32554857
 
 
|keywords=* extracellular vesicles
* follicular fluid
* microRNAs
* reproductive aging
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7343446
}}
{{medline-entry
|title=Older Adults with Physical Frailty and Sarcopenia Show Increased Levels of Circulating Small Extracellular Vesicles with a Specific Mitochondrial Signature.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32326435
 
 
|keywords=* aging
* biomarkers
* exosomes
* mitochondrial dynamics
* mitochondrial quality control
* mitochondrial-derived vesicles (MDVs)
* mitochondrial-lysosomal axis
* mitophagy
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7227017
}}
{{medline-entry
|title=Increased production of functional small extracellular vesicles in senescent endothelial cells.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32101370
 
 
|keywords=* endothelium
* exosomes
* extracellular vesicles
* senescence
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7176858
}}
==CDA==
 
{{medline-entry
|title=Cumulative Dis/Advantage and Health Pattern in Late Life: A Comparison between Genders and Welfare State Regimes.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31771483
 
|mesh-terms=* Aged
* Aged, 80 and over
* China
* Cross-Sectional Studies
* England
* Female
* Health Behavior
* Health Status Disparities
* Humans
* Longevity
* Male
* Mexico
* Middle Aged
* Regression Analysis
* Self Report
* Sex Factors
* Social Class
* Social Welfare
* United States
|keywords=* Cumulative dis/advantage
* cross-national study
* health retirement study
* welfare state theory
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7367435
}}
{{medline-entry
|title=Does numerical similarity alter age-related distractibility in working memory?
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31483830
 
|mesh-terms=* Adult
* Aged
* Aging
* Alpha Rhythm
* Attention
* Evoked Potentials
* Female
* Healthy Volunteers
* Humans
* Male
* Memory, Short-Term
* Young Adult
 
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6726243
}}
==CDC20==
 
{{medline-entry
|title=Premature aging syndrome showing random chromosome number instabilities with [[CDC20]] mutation.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/33094908
 
 
|keywords=* Cdc20 proteins
* M phase cell cycle checkpoints
* aging
* chromosomal instability
* chromosome segregation
* genomic instability
* premature
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7681047
}}
==CDC25A==
 
{{medline-entry
|title=Babam2 Regulates Cell Cycle Progression and Pluripotency in Mouse Embryonic Stem Cells as Revealed by Induced DNA Damage.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/33050379
 
 
|keywords=* Babam2
* DNA damage
* cell cycle
* embryonic stem cells
* pluripotency
* senescence
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7600899
}}
==CDC42==
 
{{medline-entry
|title=Effects of age-dependent changes in cell size on endothelial cell proliferation and senescence through YAP1.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31487690
 
|mesh-terms=* Adaptor Proteins, Signal Transducing
* Adult
* Aging
* Animals
* Cell Cycle Proteins
* Cell Size
* Endothelial Cells
* Female
* Humans
* Male
* Mice, Inbred C57BL
* Middle Aged
* Neovascularization, Physiologic
* Primary Cell Culture
* Transcription Factors
* cdc42 GTP-Binding Protein
|keywords=* aging
* angiogenesis
* cell proliferation
* cell size
* senescence
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6756888
}}
==CDH1==
 
{{medline-entry
|title=Cdc6 as a novel target in cancer: Oncogenic potential, senescence and subcellular localisation.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32010971
 
 
|keywords=* Cdc6
* cytoplasmic Cdc6
* pancreatic cancer
* senescence
* subcellular localisation
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7496346
}}
==CDK1==
 
{{medline-entry
|title=MicroRNAomic Transcriptomic Analysis Reveal Deregulation of Clustered Cellular Functions in Human Mesenchymal Stem Cells During in Vitro Passaging.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31848878
 
|mesh-terms=* CDC2-CDC28 Kinases
* Cell Differentiation
* Cell Proliferation
* Cellular Senescence
* Cyclin B
* Gene Expression Regulation, Developmental
* Humans
* Mesenchymal Stem Cells
* MicroRNAs
* Transcriptome
* Tumor Suppressor Protein p53
* Umbilical Cord
|keywords=* Cell proliferation
* Cell senescence
* Cellular ageing
* Human Mesenchymal stem / stromal cells
* miRNA-mRNA integration
|full-text-url=https://sci-hub.do/10.1007/s12015-019-09924-0
}}
==CDK2==
 
{{medline-entry
|title=p57  is a master regulator of human adipose derived stem cell quiescence and senescence.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32224418
 
 
|keywords=* Human adipose derived stem cells
* Quiescence
* Senescence
* p57(Kip2)
|full-text-url=https://sci-hub.do/10.1016/j.scr.2020.101759
}}
==CDK4==
 
{{medline-entry
|title=Emerging Roles for the [i]INK4a/ARF[/i] ([i]CDKN2A[/i]) Locus in Adipose Tissue: Implications for Obesity and Type 2 Diabetes.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32971832
 
 
|keywords=* adipogenesis
* inflammation
* insulin sensitivity
* obesity
* oxidative activity
* senescence
* type 2 diabetes
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7563355
}}
{{medline-entry
|title=Guilu Erxian Glue () Inhibits Chemotherapy-Induced Bone Marrow Hematopoietic Stem Cell Senescence in Mice May via p16 -Rb Signaling Pathway.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32915425
 
 
|keywords=* Chinese medicine
* Guilu Erxian Glue
* bone marrow suppression
* hematopoietic stem cell senescence
* p16INK4a
|full-text-url=https://sci-hub.do/10.1007/s11655-020-3098-3
}}
==CDK5==
 
{{medline-entry
|title=Age-related hyperinsulinemia leads to insulin resistance in neurons and cell-cycle-induced senescence.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31636448
 
|mesh-terms=* Aging
* Animals
* Cell Cycle
* Cell Death
* Cellular Senescence
* Cyclin-Dependent Kinase 5
* Excitatory Postsynaptic Potentials
* Gene Expression
* Glycolysis
* Hexokinase
* Hyperinsulinism
* Inhibitory Postsynaptic Potentials
* Insulin
* Insulin Resistance
* Liraglutide
* Male
* Maze Learning
* Metformin
* Mice
* Neurons
* Phosphotransferases
* Primary Cell Culture
* Protein-Serine-Threonine Kinases
* Ubiquitination
* beta Catenin
 
|full-text-url=https://sci-hub.do/10.1038/s41593-019-0505-1
}}
==CDK6==
 
{{medline-entry
|title=Saturated Fatty Acids Promote Hepatocytic Senecence through Regulation of miR-34a/Cyclin-Dependent Kinase 6.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32970940
 
 
|keywords=* cyclin-dependent kinase 6 (CDK6)
* high-fat diet (HFD)
* miR-34a
* palmitate acid (PA)
* senescence
|full-text-url=https://sci-hub.do/10.1002/mnfr.202000383
}}
{{medline-entry
|title=Hepatoprotective effects of hydroxysafflor yellow A in D-galactose-treated aging mice.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32454116
 
 
|keywords=* D-galactose
* Hydroxysafflor yellow A
* Oxidative stress
* Replicative senescence
* p16
|full-text-url=https://sci-hub.do/10.1016/j.ejphar.2020.173214
}}
{{medline-entry
|title=Anti-cell growth and anti-cancer stem cell activity of the CDK4/6 inhibitor palbociclib in breast cancer cells.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31823286
 
 
|keywords=* Breast cancer
* CDK4
* Cancer stem cells
* Palbociclib
* Senescence
|full-text-url=https://sci-hub.do/10.1007/s12282-019-01035-5
}}
{{medline-entry
|title=Compromising the constitutive p16  expression sensitizes human neuroblastoma cells to Hsp90 inhibition and promotes premature senescence.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31692039
 
 
|keywords=* 17AAG
* Hsp90
* cancer
* p16INK4a
* senescence
* tumor suppressor
|full-text-url=https://sci-hub.do/10.1002/jcb.29493
}}
==CDKN1A==
 
{{medline-entry
|title=Involvement of [[CDKN1A]] (p21) in cellular senescence in response to heat and irradiation stress during preimplantation development.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32253738
 
 
|keywords=* Cdkn1a
* Heat stress
* Irradiation
* Preimplantation
* Senescence
* p21
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7193008
}}
==CDKN2A==
 
{{medline-entry
|title=Association between Nrf2 and [[CDKN2A]] expression in patients with end-stage renal disease: a pilot study.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32661200
 
 
|keywords=* CDKN2A
* Nrf2
* aging
* end-stage renal disease
* inflammation
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7485736
}}
==CDKN2B==
 
{{medline-entry
|title=Molecular Genetics and Functional Analysis Implicate [i][[CDKN2B]]AS1-[[CDKN2B]][/i] Involvement in POAG Pathogenesis.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32825664
 
 
|keywords=* African Americans
* CDKN2B-AS1
* Primary open-angle glaucoma (POAG)
* senescence
* trabecular meshwork cells
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7564117
}}
==CFI==
 
{{medline-entry
|title=Psychosocial Resources for Hedonic Balance, Life Satisfaction and Happiness in the Elderly: A Path Analysis.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32781590
 
|mesh-terms=* Adult
* Aged
* Aged, 80 and over
* Aging
* Cross-Sectional Studies
* Female
* Happiness
* Health Status
* Humans
* Male
* Personal Satisfaction
* Quality of Life
|keywords=* happiness
* older adults
* path analysis
* psychosocial resources
* subjective well-being
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7459462
}}
{{medline-entry
|title=Validity and Reliability of the Flourishing Scale in a Sample of Older Adults in Iran.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32546985
 
|mesh-terms=* Aged
* Aging
* Cross-Sectional Studies
* Female
* Geriatric Assessment
* Health Status Disparities
* Humans
* Iran
* Male
* Mental Health
* Psychometrics
* Reproducibility of Results
* Surveys and Questionnaires
|keywords=* aging
* factor analysis
* flourishing
* reliability
* validity
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7244746
}}
{{medline-entry
|title=The decision about retirement: A scale to describe representations and practices of medical doctors and nurses.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32258559
 
 
|keywords=* Aging
* Job satisfaction
* Retirement
* Scale
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6806742
}}
{{medline-entry
|title=Family versus intimate partners: Estimating who matters more for health in a 20-year longitudinal study.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31697103
 
|mesh-terms=* Adult
* Aged
* Aging
* Emotions
* Family Relations
* Female
* Health Status
* Humans
* Interpersonal Relations
* Longitudinal Studies
* Male
* Middle Aged
* Sexual Partners
* United States
 
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7012715
}}
{{medline-entry
|title=Adapting and validating the Rosenberg Self-Esteem Scale for elderly Spanish population.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31524131
 
 
|keywords=* aging
* life span
* self-esteem
* structural equation model
* validity
|full-text-url=https://sci-hub.do/10.1017/S1041610219001170
}}
==CFTR==
 
{{medline-entry
|title=Exercise Physiology Across the Lifespan in Cystic Fibrosis.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31780953
 
 
|keywords=* aging
* cystic fibrosis
* exercise capacity
* exercise prescription
* pediatric
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6856653
}}
{{medline-entry
|title=Reduced expression of the Ion channel [[CFTR]] contributes to airspace enlargement as a consequence of aging and in response to cigarette smoke in mice.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31477092
 
|mesh-terms=* Aging
* Animals
* Cystic Fibrosis Transmembrane Conductance Regulator
* Gene Expression
* Inhalation Exposure
* Mice
* Mice, Knockout
* Pulmonary Emphysema
* Tobacco Smoke Pollution
|keywords=* Aging
* CFTR
* Emphysema
* Smoking
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6720379
}}
==CGA==
 
{{medline-entry
|title=Safety and efficacy of preoperative chemoradiotherapy in fit older patients with intermediate or locally advanced rectal cancer evaluated by comprehensive geriatric assessment: A planned interim analysis of a multicenter, phase II trial.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/33160954
 
 
|keywords=* Comprehensive geriatric assessment
* Geriatrics
* Preoperative chemoradiotherapy
* Rectal cancer
|full-text-url=https://sci-hub.do/10.1016/j.jgo.2020.10.016
}}
{{medline-entry
|title=The Protective Effect of Chlorogenic Acid on Vascular Senescence via the Nrf2/HO-1 Pathway.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32630570
 
 
|keywords=* chlorogenic acid
* heme oxygenase-1
* nuclear factor erythroid 2-related factor 2
* vascular senescence
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7350250
}}
{{medline-entry
|title=Association between comprehensive geriatric assessment and short-term outcomes among older adult patients with stroke: A nationwide retrospective cohort study using propensity score and instrumental variable methods.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32566923
 
 
|keywords=* Comprehensive geriatric assessment
* Geriatrics
* Japanese diagnosis procedure combination database
* Length of stay
* Mortality
* Stroke
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7298723
}}
{{medline-entry
|title=Interventions to Improve Clinical Outcomes in Older Adults Admitted to a Surgical Service: A Systematic Review and Meta-analysis.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32417101
 
 
|keywords=* Aging
* comprehensive geriatric assessment
* delirium
* functional status
* outcomes
* surgery
|full-text-url=https://sci-hub.do/10.1016/j.jamda.2020.03.023
}}
{{medline-entry
|title=A Computerized Frailty Assessment Tool at Points-of-Care: Development of a Standalone Electronic Comprehensive Geriatric Assessment/Frailty Index (eFI-[[CGA]]).
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32296673
 
 
|keywords=* aging
* comprehensive geriatric assessment (CGA)
* electronic assessment tools
* frailty
* frailty index
* healthcare
* older adults
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7137764
}}
{{medline-entry
|title=Allocating patients to geriatric medicine wards in a tertiary university hospital in England: A service evaluation of the Specialist Advice for the Frail Elderly (SAFE) team.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31942488
 
 
|keywords=* clinical frailty scale
* frail older adults
* geriatrics
* hospital medicine
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6880728
}}
{{medline-entry
|title=Role of Frailty on Risk Stratification in Cardiac Surgery and Procedures.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31894551
 
|mesh-terms=* Aged
* Aged, 80 and over
* Cardiac Surgical Procedures
* Frail Elderly
* Frailty
* Geriatric Assessment
* Humans
* Percutaneous Coronary Intervention
* Risk Assessment
* Transcatheter Aortic Valve Replacement
|keywords=* Cardiac surgery
* Comprehensive geriatric assessment
* Disability
* Elderly
* Frailty
* Geriatrics
* Surgical risk scores
* TAVI
|full-text-url=https://sci-hub.do/10.1007/978-3-030-33330-0_11
}}
{{medline-entry
|title=Developing an objective structured clinical examination in comprehensive geriatric assessment - A pilot study.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31745004
 
|mesh-terms=* Aged
* Clinical Competence
* Education, Medical, Graduate
* Educational Measurement
* Female
* Geriatric Assessment
* Geriatrics
* Humans
* Male
* Pilot Projects
* United Kingdom
|keywords=* Comprehensive geriatric assessment
* development
* entrustable professional capabilities
* objective structured clinical examination
* summative assessment
|full-text-url=https://sci-hub.do/10.4103/efh.EfH_111_18
}}
{{medline-entry
|title=How do doctors choose treatment for older gynecological cancer patients? A Japanese Gynecologic Oncology Group survey of gynecologic oncologists.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31728682
 
|mesh-terms=* Aged
* Aged, 80 and over
* Comorbidity
* Female
* Genital Neoplasms, Female
* Geriatric Assessment
* Gynecology
* Humans
* Hysterectomy
* Japan
* Lymph Node Excision
* Oncologists
* Surveys and Questionnaires
|keywords=* Comprehensive geriatric assessment
* Elderly
* Geriatrics
* Gynecologic cancer
|full-text-url=https://sci-hub.do/10.1007/s10147-019-01574-z
}}
{{medline-entry
|title=Validation of the Pictorial Fit-Frail Scale in a memory clinic setting.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31524122
 
 
|keywords=* aging
* dementia
* frail elderly
* frailty
* psychometrics
|full-text-url=https://sci-hub.do/10.1017/S1041610219000905
}}
{{medline-entry
|title=Impact of Resolution of Hyponatremia on Neurocognitive and Motor Performance in Geriatric Patients.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31467370
 
|mesh-terms=* Activities of Daily Living
* Aged
* Aged, 80 and over
* Aging
* Cognition
* Female
* Geriatrics
* Humans
* Hyponatremia
* Male
* Mental Status and Dementia Tests
* Middle Aged
* Motor Activity
* Sodium
 
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6715723
}}
{{medline-entry
|title=Health outcome of older hospitalized patients in internal medicine environments evaluated by Identification of Seniors at Risk (ISAR) screening and geriatric assessment.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31412787
 
|mesh-terms=* Accidental Falls
* Aged
* Aged, 80 and over
* Cohort Studies
* Emergency Service, Hospital
* Female
* Geriatric Assessment
* Health Status
* Hospitalization
* Humans
* Internal Medicine
* Length of Stay
* Male
* Mass Screening
* Patient Discharge
* Risk Assessment
|keywords=* CGA
* Cutoff
* Geriatrics
* ISAR
* Internal medicine
* Older in-patients
* Risk screening
* Sensitivity
* Specificity
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6694685
}}
==CHI3L1==
 
{{medline-entry
|title=Postsynaptic damage and microglial activation in AD patients could be linked CXCR4/CXCL12 expression levels.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32949560
 
 
|keywords=* Aging
* Alzheimer’s disease
* Bioinformatics
* CHI3L1
* Chitinase
* NRGN
|full-text-url=https://sci-hub.do/10.1016/j.brainres.2020.147127
}}
==CHRNA7==
 
{{medline-entry
|title=Associations between genetic variations and global motion perception.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31432227
 
|mesh-terms=* Adult
* Differential Threshold
* Female
* Genotype
* Humans
* Male
* Motion Perception
* Polymorphism, Single Nucleotide
* Receptors, Nicotinic
* Sensory Thresholds
* Young Adult
* alpha7 Nicotinic Acetylcholine Receptor
|keywords=* Aging
* CHRNA7
* Cholinergic system
* Coherent motion
* Genetic variations
|full-text-url=https://sci-hub.do/10.1007/s00221-019-05627-7
}}
==CHSY1==
 
{{medline-entry
|title=Loss of Chondroitin Sulfate Modification Causes Inflammation and Neurodegeneration in [i]skt[/i] Mice.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31754016
 
|mesh-terms=* Age Factors
* Animals
* Apoptosis
* Chondroitin Sulfates
* Female
* Glucuronosyltransferase
* Inflammation
* Male
* Mice
* Mice, Inbred C57BL
* Mice, Knockout
* Multifunctional Enzymes
* Mutation
* N-Acetylgalactosaminyltransferases
* Neurodegenerative Diseases
* Neurons
* Protein Processing, Post-Translational
* Proteins
* Retinal Degeneration
|keywords=* aging
* chondroitin sulfate synthase
* hippocampus
* inflammation
* mouse
* myeloid cells
* neurodegeneration
* retina
* retinal pigment epithelium
* subretinal space
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6944401
}}
==CISD2==
 
{{medline-entry
|title=[[CISD2]] Attenuates Inflammation and Regulates Microglia Polarization in EOC Microglial Cells-As a Potential Therapeutic Target for Neurodegenerative Dementia.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/33005144
 
 
|keywords=* CISD2
* M1/M2 microglia polarization
* aging
* anti-inflammatory effects
* neurodegenerative disease and dementia
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7479185
}}
==CIT==
 
{{medline-entry
|title=Effect of sex on aging-related decline of dopamine transporter in healthy subjects.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/33052524
 
 
|keywords=* 123I-FP-CIT
* Aging
* Dopamine plasma membrane transport proteins
* SPECT
* Sex
|full-text-url=https://sci-hub.do/10.1007/s12149-020-01538-8
}}
{{medline-entry
|title=The Relationship Between the Striatal Dopaminergic Neuronal and Cognitive Function With Aging.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32184717
 
 
|keywords=* SPECT
* Wechsler Adult Intelligence Scale
* aging
* cognitive function
* dopamine transporter
* verbal function
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7058549
}}
==CLEC3B==
 
{{medline-entry
|title=[[CLEC3B]] p.S106G Mutant in a Caucasian Population of Successful Neurological Aging.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31570938
 
 
|keywords=*
          APOE
       
*
          CLEC3B
       
* Aging
* Human genetics
* Human health
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7494029
}}
==COL1A1==
 
{{medline-entry
|title=Remodeling process in bone of aged rats in response to resistance training.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32593709
 
|mesh-terms=* Age Factors
* Aging
* Animals
* Bone Remodeling
* Gene Expression Regulation
* Male
* Physical Conditioning, Animal
* RNA, Messenger
* Random Allocation
* Rats
* Rats, Wistar
* Resistance Training
|keywords=* Aging
* Bone homeostasis
* Function
* Resistance training
|full-text-url=https://sci-hub.do/10.1016/j.lfs.2020.118008
}}
==COL3A1==
 
{{medline-entry
|title=Different expression of Defensin-B gene in the endometrium of mares of different age during the breeding season.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31864349
 
|mesh-terms=* Aging
* Animals
* Breeding
* Defensins
* Endometrium
* Female
* Fibrosis
* Gene Expression
* Horses
* Inflammation
* Reverse Transcriptase Polymerase Chain Reaction
|keywords=* Defensin-β
* Endometrium
* Gene expression
* Immune-modulation
* Mare
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6925900
}}
==COMT==
 
{{medline-entry
|title=The geriatric pain experience in mice: intact cutaneous thresholds but altered responses to tonic and chronic pain.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32008855
 
|mesh-terms=* Acetone
* Aging
* Animals
* Behavior
* Biogenic Monoamines
* Capsaicin
* Chronic Pain
* Disease Models, Animal
* Male
* Mice, Inbred C57BL
* Peripheral Nerve Injuries
* Physical Stimulation
* Prefrontal Cortex
* Sensory Thresholds
|keywords=* Geriatric pain
* Healthy aging
* Mice
* Sensory thresholds
* Supraspinal plasticity
* Tonic and chronic pain response
|full-text-url=https://sci-hub.do/10.1016/j.neurobiolaging.2019.12.018
}}
==COPE==
 
{{medline-entry
|title=Patterns and characteristics of cognitive functioning in older patients approaching end stage kidney disease, the [[COPE]]-study.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32272897
 
 
|keywords=* Cognitive function
* End stage renal disease
* Geriatric assessment
* Geriatrics
* Older patients
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7147053
}}
==CORT==
 
{{medline-entry
|title=Sex differences in body composition, metabolism-related hormones, and energy homeostasis during aging in Wistar rats.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/33075214
 
 
|keywords=* aging
* body composition
* energy metabolism
* metabolism-related hormone
* sex differences
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7571994
}}
{{medline-entry
|title=Effects of age and social isolation on murine hippocampal biochemistry and behavior.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32866520
 
 
|keywords=* Aging
* Hippocampus
* Inflammation
* Memory
* Serotonin
* Social isolation
* Stress
|full-text-url=https://sci-hub.do/10.1016/j.mad.2020.111337
}}
{{medline-entry
|title=Interleukin 6 reduces allopregnanolone synthesis in the brain and contributes to age-related cognitive decline in mice.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32669383
 
 
|keywords=* Alzheimer’s disease
* aging
* cognitive function
* enzyme regulation
* inflammation
* neurosteroid
* progesterone
* steroid hormones
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7529050
}}
{{medline-entry
|title=Sex- and age-dependent differences in the hormone and drinking responses to water deprivation.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31967852
 
|mesh-terms=* Age Factors
* Animals
* Arginine Vasopressin
* Behavior, Animal
* Dehydration
* Drinking
* Female
* Male
* Rats, Wistar
* Sex Factors
* Sodium Chloride
* Subfornical Organ
* Water Deprivation
|keywords=* aging
* hormonal response
* sex differences
* sodium appetite
* thirst
|full-text-url=https://sci-hub.do/10.1152/ajpregu.00303.2019
}}
{{medline-entry
|title=Ontogeny of the adrenocortical response in an extremely altricial bird.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31545013
 
|mesh-terms=* Adrenal Glands
* Aging
* Animals
* Corticosterone
* Female
* Hypothalamo-Hypophyseal System
* Male
* Parrots
* Restraint, Physical
* Stress, Physiological
|keywords=* Venezuela
* adrenocortical
* altricial
* birds
* corticosterone
* glucocorticoid
* hypothalamic-pituitary-adrenal axis
* ontogeny
* parrots
* stress
|full-text-url=https://sci-hub.do/10.1002/jez.2317
}}
==CP==
 
{{medline-entry
|title=A Life Course Perspective on Growing Older With Cerebral Palsy.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/33213304
 
 
|keywords=* aging
* cerebral palsy
* midlife
* neurological disorders
* neurology
* qualitative descriptive
|full-text-url=https://sci-hub.do/10.1177/1049732320971247
}}
{{medline-entry
|title=The molecular anatomy and functions of the choroid plexus in healthy and diseased brain.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32750317
 
 
|keywords=* Aging
* Alzheimer's disease
* Choroid plexus
* Development
* Multiple sclerosis
* Neuroprotection
|full-text-url=https://sci-hub.do/10.1016/j.bbamem.2020.183430
}}
{{medline-entry
|title=The effects and mechanism of collagen peptide and elastin peptide on skin aging induced by D-galactose combined with ultraviolet radiation.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32717457
 
 
|keywords=* Collagen
* D-galactose
* Elastin
* Skin aging
* Ultraviolet
|full-text-url=https://sci-hub.do/10.1016/j.jphotobiol.2020.111964
}}
{{medline-entry
|title=Model based strategies towards protein A resin lifetime optimization and supervision.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32709318
 
|mesh-terms=* Algorithms
* Chromatography
* Kinetics
* Least-Squares Analysis
* Ligands
* Models, Theoretical
* Principal Component Analysis
* Resins, Plant
* Staphylococcal Protein A
* Statistics as Topic
|keywords=* Cleaning procedures
* Hybrid modeling
* Multivariate data analysis
* Protein A chromatography
* Resin aging
* Resin lifetime
|full-text-url=https://sci-hub.do/10.1016/j.chroma.2020.461261
}}
{{medline-entry
|title=The influence of age and environmental conditions on supplement intake by beef cattle winter grazing northern mixed-grass rangelands.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32658282
 
|mesh-terms=* Aging
* Animal Feed
* Animal Husbandry
* Animals
* Cattle
* Diet
* Dietary Supplements
* Ecosystem
* Female
* Poaceae
* Seasons
* Weather
|keywords=* beef cattle
* cow age
* environment
* supplement intake
* winter grazing
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7455287
}}
{{medline-entry
|title=Cyclophosphamide, a cancer chemotherapy drug-induced early onset of reproductive senescence and alterations in reproductive performance and their prevention in mice.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32536211
 
 
|keywords=* Cyclophosphamide
* Decalepis hamiltonii
* premature ovarian failure
* reproductive performance
* reproductive senescence
* uterus
|full-text-url=https://sci-hub.do/10.1080/01480545.2020.1774773
}}
{{medline-entry
|title=Asymptomatic [i]Clostridium perfringens[/i] Inhabitation in Intestine Can Cause Inflammation, Apoptosis, and Disorders in Brain.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31928429
 
|mesh-terms=* Aging
* Animals
* Apoptosis
* Asymptomatic Infections
* Brain
* Brain Diseases
* Clostridium Infections
* Clostridium perfringens
* Disease Models, Animal
* Feces
* Food Microbiology
* Gene Expression
* Humans
* Inflammation
* Intestines
* Liver
* Male
* Mice
* Mice, Inbred C57BL
* Organ Size
* Oxidative Stress
* Risk Factors
* Spleen
|keywords=* Clostridium perfringens
* brain damage
* brain disorder
* gut microbiota
|full-text-url=https://sci-hub.do/10.1089/fpd.2019.2677
}}
{{medline-entry
|title=The Role of the Clinical Pharmacist in the Management of People Living with HIV in the Modern Antiretroviral Era.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31834321
 
|mesh-terms=* Aged
* Aged, 80 and over
* Anti-Retroviral Agents
* Disease Management
* Disease Transmission, Infectious
* Female
* HIV Infections
* Humans
* Male
* Medication Adherence
* Middle Aged
* Pharmacists
* Professional Role
* Treatment Outcome
|keywords=* Aging
* Antiretroviral therapy
* Clinical pharmacist
* Comorbidities
* HIV
|full-text-url=https://sci-hub.do/10.24875/AIDSRev.19000089
}}
{{medline-entry
|title=A clinically feasible method for the assessment and characterization of pain in patients with chronic pancreatitis.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31787527
 
|mesh-terms=* Adult
* Aging
* Case-Control Studies
* Cross-Sectional Studies
* Humans
* Middle Aged
* Pain
* Pain Measurement
* Pancreatitis, Chronic
* Sex Factors
|keywords=* Central sensitization
* Chronic pancreatitis
* Nociception
* Pain
|full-text-url=https://sci-hub.do/10.1016/j.pan.2019.11.007
}}
{{medline-entry
|title=Differences in geometric strength at the contralateral hip between men with hip fracture and non-fractured comparators.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31812699
 
 
|keywords=* Aging
* DXA
* Fracture prevention
* Injury/fracture healing
* Osteoporosis
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7037571
}}
{{medline-entry
|title=Factors associated with the number of clinical pharmacy recommendations: findings from an observational study in geriatric inpatients.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31642397
 
 
|keywords=* Clinical pharmacy
* geriatrics
* inpatients
* polypharmacy
* risk stratification
|full-text-url=https://sci-hub.do/10.1080/17843286.2019.1683128
}}
{{medline-entry
|title=Protection against oxidative stress and anti-aging effect in Drosophila of royal jelly-collagen peptide.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31622731
 
|mesh-terms=* Aging
* Amino Acids
* Animals
* Body Weight
* Collagen
* Drosophila
* Fatty Acids
* Feeding Behavior
* Hydrogen Peroxide
* Longevity
* Molecular Weight
* Oxidative Stress
* Paraquat
|keywords=* Anti-aging
* Antioxidant activity
* Collagen
* Drosophila
* Royal jelly
|full-text-url=https://sci-hub.do/10.1016/j.fct.2019.110881
}}
==CPM==
 
{{medline-entry
|title=Test-Retest Instability of Temporal Summation and Conditioned Pain Modulation Measures in Older Adults.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/33083842
 
 
|keywords=* Aging
* Anxiety
* Conditioned Pain Modulation
* Pain Catastrophizing
* Reliability
* Temporal Summation of Pain
|full-text-url=https://sci-hub.do/10.1093/pm/pnaa288
}}
{{medline-entry
|title=Age does not affect sex effect of conditioned pain modulation of pressure and thermal pain across 2 conditioning stimuli.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32072094
 
 
|keywords=* Aging
* CPM duration
* Conditioned pain modulation
* Conditioning stimulus
* Sex differences
* Test stimulus
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7004505
}}
{{medline-entry
|title=The Decline of Endogenous Pain Modulation With Aging: A Meta-Analysis of Temporal Summation and Conditioned Pain Modulation.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31562994
 
 
|keywords=* Aging
* conditioned pain modulation
* meta-analysis
* pain modulation
* temporal summation
|full-text-url=https://sci-hub.do/10.1016/j.jpain.2019.09.005
}}
==CPNE1==
 
{{medline-entry
|title=Prevalent intron retention fine-tunes gene expression and contributes to cellular senescence.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/33274830
 
 
|keywords=* CPNE1
* U2AF1
* intron retention
* senescence
* splicing factor
|full-text-url=https://sci-hub.do/10.1111/acel.13276
}}
==CPT1A==
 
{{medline-entry
|title=Alteration of fatty acid oxidation by increased [[CPT1A]] on replicative senescence of placenta-derived mesenchymal stem cells.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31900237
 
 
|keywords=* CPT1A
* Fatty acid
* Mitochondria
* Placenta-derived mesenchymal stem cell
* Senescence
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6941254
}}
==CPT1C==
 
{{medline-entry
|title=Carnitine palmitoyltransferase 1C reverses cellular senescence of MRC-5 fibroblasts via regulating lipid accumulation and mitochondrial function.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32632982
 
 
|keywords=* MRC-5 fibroblasts
* carnitine palmitoyltransferase 1C (CPT1C)
* cellular senescence
* lipidomics
* mitochondrial function
|full-text-url=https://sci-hub.do/10.1002/jcp.29906
}}
{{medline-entry
|title=Carnitine palmitoyltransferase 1C contributes to progressive cellular senescence.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32289751
 
 
|keywords=* carnitine palmitoyltransferase 1C
* metabolic reprogramming
* mitochondria
* senescence
* stable transfection
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7202531
}}
==CPT2==
 
{{medline-entry
|title=The phytochemical epigallocatechin gallate prolongs the lifespan by improving lipid metabolism, reducing inflammation and oxidative stress in high-fat diet-fed obese rats.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32729662
 
 
|keywords=* EGCG
* free fatty acid
* high-fat dietary
* lifespan
* proteomics
* transcriptome
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7511879
}}
==CR1==
 
{{medline-entry
|title=Single Nucleotide Polymorphisms in Alzheimer's Disease Risk Genes Are Associated with Intrinsic Connectivity in Middle Age.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32986668
 
 
|keywords=* Aging
* Alzheimer’s disease
* middle aged
* neuroimaging
* single nucleotide
polymorphism
|full-text-url=https://sci-hub.do/10.3233/JAD-200444
}}
{{medline-entry
|title=The whale shark genome reveals how genomic and physiological properties scale with body size.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32753383
 
|mesh-terms=* Adaptation, Physiological
* Animals
* Base Sequence
* Body Size
* Genome
* Genomics
* Longevity
* Sharks
* Temperature
|keywords=* body size
* lifespan
* metabolic rate
* neural genes
* whale shark
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7456109
}}
==CRABP2==
 
{{medline-entry
|title=Preconception resveratrol intake against infertility: Friend or foe?
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32273814
 
 
|keywords=* aging
* assisted reproductive technology
* infertility
* resveratrol
* sirtuin
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7138940
}}
==CRBN==
 
{{medline-entry
|title=Using proteolysis-targeting chimera technology to reduce navitoclax platelet toxicity and improve its senolytic activity.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32332723
 
|mesh-terms=* Adaptor Proteins, Signal Transducing
* Aging
* Aniline Compounds
* Animals
* Blood Platelets
* Cell Line
* Cellular Senescence
* Female
* Humans
* Male
* Mice
* Mice, Transgenic
* Models, Animal
* Primary Cell Culture
* Proteolysis
* Sulfonamides
* Ubiquitin-Protein Ligases
* bcl-X Protein
 
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7181703
}}
==CRP==
 
{{medline-entry
|title=Omega-3 supplementation improves isometric strength but not muscle anabolic and catabolic signaling in response to resistance exercise in healthy older adults.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/33284965
 
 
|keywords=* Muscle wasting
* aging
* anabolic resistance
* inflammation
* resistance training
* sarcopenia
|full-text-url=https://sci-hub.do/10.1093/gerona/glaa309
}}
{{medline-entry
|title=Circulating angiopoietin-like protein 2 levels and arterial stiffness in patients receiving maintenance hemodialysis: A cross-sectional study.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/33197687
 
 
|keywords=* Angiopoietin-like protein (ANGPTL) 2
* Cardio-ankle vascular index (CAVI)
* Chronic inflammation
* Hemodialysis
* Senescence
|full-text-url=https://sci-hub.do/10.1016/j.atherosclerosis.2020.10.890
}}
{{medline-entry
|title=Cardiovascular rehabilitation in patients aged 70-year-old or older: benefits on functional capacity, physical activity and metabolic profile in younger [i]vs[/i]. older patients.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/33117418
 
 
|keywords=* Aging
* Cardiovascular prevention
* Exercise-based cardiac rehabilitation
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7568038
}}
{{medline-entry
|title=rRT-PCR Results of a Covid-19 Diagnosed Geriatric Patient.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/33103060
 
 
|keywords=* COVID-19
* False negative reactions
* Geriatrics
* Mass screening
* Reverse transcriptase polymerase chain reaction
* SARS-CoV-2
* Tomography
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7567648
}}
{{medline-entry
|title=The Association of Aging Biomarkers, Interstitial Lung Abnormalities, and Mortality.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/33080140
 
 
|keywords=* aging
* growth differentiation factor 15
* idiopathic pulmonary fibrosis
* interstitial lung abnormalities
* mortality
|full-text-url=https://sci-hub.do/10.1164/rccm.202007-2993OC
}}
{{medline-entry
|title=A Novel Fortified Dairy Product and Sarcopenia Measures in Sarcopenic Older Adults: A Double-Blind Randomized Controlled Trial.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/33067129
 
 
|keywords=* Functional food
* aging
* beta-hydroxy beta-methylbutyrate
* muscle strength
* sarcopenia
* vitamin D
|full-text-url=https://sci-hub.do/10.1016/j.jamda.2020.08.035
}}
{{medline-entry
|title=Age-Related Colonic Mucosal Microbiome Community Shifts in Monkeys.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/33021628
 
 
|keywords=* Aging
* Microbial co-occurrences
* Mucosal microbiome
* Systemic inflammation
|full-text-url=https://sci-hub.do/10.1093/gerona/glaa256
}}
{{medline-entry
|title=The relationship between frailty and serum alpha klotho levels in geriatric patients.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32905907
 
 
|keywords=* Aging
* Biomarkers
* Frailty syndrome
* Geriatric syndrome
* Sarcopenia
|full-text-url=https://sci-hub.do/10.1016/j.archger.2020.104225
}}
{{medline-entry
|title=ZMPSTE24 Is Associated with Elevated Inflammation and Progerin mRNA.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32872320
 
 
|keywords=* ZMPSTE24
* aging
* inflammation
* lamin A/C
* progerin
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7563344
}}
{{medline-entry
|title=Cultural and life style practices associated with low inflammatory physiology in Japanese adults.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32805392
 
 
|keywords=* Aging
* Bathing
* C-reactive protein
* Diet
* Inflammation
* Interleukin-6
* Japan
* Tea
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7544652
}}
{{medline-entry
|title=Moderate- to high intensity aerobic and resistance exercise reduces peripheral blood regulatory cell populations in older adults with rheumatoid arthritis.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32467712
 
 
|keywords=* Aging
* Breg cells
* Exercise
* IL-10
* Rheumatoid arthritis
* T cells
* Treg cells
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7229606
}}
{{medline-entry
|title=PTSD and the klotho longevity gene: Evaluation of longitudinal effects on inflammation via DNA methylation.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32438247
 
 
|keywords=* Accelerated aging
* Inflammation
* Klotho
* Methylation
* PTSD
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7293549
}}
{{medline-entry
|title=Bereavement is associated with reduced systemic inflammation: C-reactive protein before and after widowhood.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32283288
 
 
|keywords=* Aging
* Bereavement
* C-reactive protein
* Health
* Inflammation
* Widowhood
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7415735
}}
{{medline-entry
|title=The Impact of Age on the Prevalence of Sarcopenic Obesity in Bariatric Surgery Candidates.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32249368
 
 
|keywords=* Aging
* Bariatric surgery
* Elderly
* Obesity
* Sarcopenia
|full-text-url=https://sci-hub.do/10.1007/s11695-019-04198-4
}}
{{medline-entry
|title=Intake of dietary advanced glycation end products influences inflammatory markers, immune phenotypes, and antiradical capacity of healthy elderly in a little-studied population.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32148813
 
 
|keywords=* CRP
* advanced glycationed end products
* aging
* dAGE
* immunity
* inflammation
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7020308
}}
{{medline-entry
|title=Intentional Switching Between Bimanual Coordination Patterns in Older Adults: Is It Mediated by Inhibition Processes?
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32132919
 
 
|keywords=* Stroop task
* aging
* bimanual coordination
* inhibition
* mediation analysis
* switching
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7041435
}}
{{medline-entry
|title=Shorter Telomere Length in Peripheral Blood Leukocytes Is Associated with Post-Traumatic Chronic Osteomyelitis.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32125944
 
 
|keywords=* aging
* post-traumatic chronic osteomyelitis
* telomere
|full-text-url=https://sci-hub.do/10.1089/sur.2019.326
}}
{{medline-entry
|title=Risk Factors of Progression to Frailty: Findings from the Singapore Longitudinal Ageing Study.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31886815
 
|mesh-terms=* Aged
* Aged, 80 and over
* Aging
* Disease Progression
* Female
* Frail Elderly
* Frailty
* Geriatric Assessment
* Humans
* Independent Living
* Longitudinal Studies
* Male
* Nutrition Assessment
* Nutritional Status
* Physical Examination
* Risk Factors
* Singapore
* Socioeconomic Factors
|keywords=* Frailty
* longitudinal
* risk factors
* transition
|full-text-url=https://sci-hub.do/10.1007/s12603-019-1277-8
}}
{{medline-entry
|title=Physical Function and Strength in Relation to Inflammation in Older Adults with Obesity and Increased Cardiometabolic Risk.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31781724
 
|mesh-terms=* Aged
* Aging
* Cardiovascular Diseases
* Female
* Humans
* Inflammation
* Male
* Muscle Strength
* Obesity
* Physical Exertion
|keywords=* Inflammation
* cardiovascular disease risk factors
* obesity
* physical activity
* physical function
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6996491
}}
{{medline-entry
|title=Key diagnostic characteristics of fever of unknown origin in Japanese patients: a prospective multicentre study.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31748308
 
|mesh-terms=* Adult
* Aged
* Aged, 80 and over
* Female
* Fever of Unknown Origin
* Humans
* Japan
* Male
* Middle Aged
* Prospective Studies
* Young Adult
|keywords=* Japan
* aging population
* elderly
* erythrocyte sedimentation rate
* fever of unknown origin
* prospective studies
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6886908
}}
{{medline-entry
|title=Decrease in Serum Vitamin D Level of Older Patients with Fatigue.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31635199
 
|mesh-terms=* Aged
* Cohort Studies
* Fatigue
* Female
* Humans
* Male
* Middle Aged
* Vitamin D
* Vitamin D Deficiency
|keywords=* aging
* mental fatigue
* older
* physical fatigue
* sex differences
* vitamin D
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6836014
}}
{{medline-entry
|title=The Association between Frailty Indicators and Blood-Based Biomarkers in Early-Old Community Dwellers of Thailand.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31533354
 
|mesh-terms=* Aged
* Aged, 80 and over
* Biomarkers
* C-Reactive Protein
* CD4-CD8 Ratio
* Cross-Sectional Studies
* Female
* Frail Elderly
* Frailty
* Humans
* Independent Living
* Interleukin-6
* Male
* Middle Aged
* Thailand
|keywords=* C-reactive protein
* Thailand
* aging
* cross-sectional study
* frailty
* frailty biomarkers
* fried’s phenotypes
* interleukin-6
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6765843
}}
{{medline-entry
|title=Associations of C-reactive protein and homocysteine concentrations with the impairment of intrinsic capacity domains over a 5-year follow-up among community-dwelling older adults at risk of cognitive decline (MAPT Study).
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31493520
 
|mesh-terms=* Activities of Daily Living
* Aged
* Biomarkers
* Body Mass Index
* C-Reactive Protein
* Cognitive Dysfunction
* Depression
* Female
* Follow-Up Studies
* Geriatric Assessment
* Hand Strength
* Homocysteine
* Humans
* Independent Living
* Inflammation
* Male
* Mobility Limitation
* Neuropsychological Tests
* Prospective Studies
* Risk Factors
* Time Factors
|keywords=* Aging
* C-reactive protein
* Homocysteine
* Inflammation
* Intrinsic capacity
* Older adults
|full-text-url=https://sci-hub.do/10.1016/j.exger.2019.110716
}}
{{medline-entry
|title=Longitudinal analysis of loneliness and inflammation at older ages: English longitudinal study of ageing.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31494341
 
|mesh-terms=* Age Factors
* Aged
* Aged, 80 and over
* Aging
* C-Reactive Protein
* England
* Female
* Ferritins
* Fibrinogen
* Humans
* Inflammation
* Loneliness
* Longitudinal Studies
* Male
* Middle Aged
|keywords=* C-reactive protein
* Ferritin
* Fibrinogen
* Inflammation
* Loneliness
|full-text-url=https://sci-hub.do/10.1016/j.psyneuen.2019.104421
}}
{{medline-entry
|title=The cortisol burden in elderly subjects with metabolic syndrome and its association with low-grade inflammation.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31471891
 
|mesh-terms=* Aged
* Aged, 80 and over
* Echocardiography
* Female
* Humans
* Hydrocortisone
* Inflammation
* Male
* Metabolic Syndrome
|keywords=* Aging
* Cortisol
* Inflammation
* Metabolic syndrome
|full-text-url=https://sci-hub.do/10.1007/s40520-019-01322-3
}}
{{medline-entry
|title=Recurrent circadian fasting (RCF) improves blood pressure, biomarkers of cardiometabolic risk and regulates inflammation in men.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31426866
 
|mesh-terms=* Adult
* Biomarkers
* Blood Pressure
* C-Reactive Protein
* Cardiovascular Diseases
* Circadian Rhythm
* Diet
* Energy Intake
* Fasting
* Heart Rate
* Humans
* Inflammation
* Male
* Metabolic Diseases
* Middle Aged
* Nutritional Physiological Phenomena
* Regression Analysis
* Risk Factors
* Young Adult
|keywords=* Aging
* Health benefits
* Inflammation
* Recurrent fasting
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6700786
}}
{{medline-entry
|title=Characteristics of patients with rheumatoid arthritis undergoing primary total joint replacement: A 14-year trend analysis (2004-2017).
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31393198
 
|mesh-terms=* Adult
* Aged
* Antirheumatic Agents
* Arthritis, Rheumatoid
* Arthroplasty, Replacement
* Arthroplasty, Replacement, Knee
* Biological Products
* Drug Utilization
* Female
* Humans
* Japan
* Male
* Middle Aged
* Postoperative Complications
|keywords=* C-reactive protein
* Rheumatoid arthritis
* aging
* arthroplasty
* drug therapy
|full-text-url=https://sci-hub.do/10.1080/14397595.2019.1649111
}}
==CS==
 
{{medline-entry
|title=Acute effect of bodyweight-based strength training on blood pressure of hypertensive older adults: A randomized crossover clinical trial.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/33198514
 
 
|keywords=* Exercise
* aging
* hypertension
* hypotension
* resistance training
|full-text-url=https://sci-hub.do/10.1080/10641963.2020.1847130
}}
{{medline-entry
|title=Particle growth with photochemical age from new particle formation to haze in the winter of Beijing, China.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/33207435
 
 
|keywords=* Condensation sink
* Haze
* New particle formation
* Photochemical aging
* Pollution evolution
|full-text-url=https://sci-hub.do/10.1016/j.scitotenv.2020.142207
}}
{{medline-entry
|title=Effect of aging on stabilization of Cd and Ni by biochars and enzyme activities in a historically contaminated alkaline agricultural soil simulated with wet-dry and freeze-thaw cycling.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/33143976
 
 
|keywords=* Accelerated aging
* Biochar
* Cadmium
* Enzyme activity
* Heavy metal stabilization
* Soil remediation
|full-text-url=https://sci-hub.do/10.1016/j.envpol.2020.115846
}}
{{medline-entry
|title=Cockayne syndrome proteins [[CS]]A and [[CS]]B maintain mitochondrial homeostasis through NAD  signaling.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/33166073
 
 
|keywords=* AMPK
* Cockayne syndrome
* NAD+
* accelerated ageing
* aging
* mitochondrial maintenance
* mitophagy
|full-text-url=https://sci-hub.do/10.1111/acel.13268
}}
{{medline-entry
|title=Vision Impairment and Participation in Cognitively Stimulating Activities: The Health ABC Study.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32710546
 
 
|keywords=* Cognition
* Cognitive Aging
* Sensory
* Vision loss
|full-text-url=https://sci-hub.do/10.1093/gerona/glaa184
}}
{{medline-entry
|title=Suspension training vs. traditional resistance training: effects on muscle mass, strength and functional performance in older adults.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32700098
 
 
|keywords=* Aging
* Functionality
* Instability resistance training
* Muscle hypertrophy
* TRX training
|full-text-url=https://sci-hub.do/10.1007/s00421-020-04446-x
}}
{{medline-entry
|title=Generational Differences in the 10-year Incidence of Impaired Contrast Sensitivity.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32693658
 
 
|keywords=* Aging
* Birth Cohort Effect
* Contrast Sensitivity
* Epidemiology
* Visual Function
|full-text-url=https://sci-hub.do/10.1080/09286586.2020.1791909
}}
{{medline-entry
|title=Inducible aging in Hydra oligactis implicates sexual reproduction, loss of stem cells, and genome maintenance as major pathways.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32578072
 
 
|keywords=* Aging
* Cold-sensitive
* DNA repair
* Gametogenesis
* Hydra oligactis
* Transcriptome
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7394996
}}
{{medline-entry
|title=Noradrenergic Responsiveness Supports Selective Attention across the Adult Lifespan.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32317388
 
|mesh-terms=* Adult
* Aged
* Aging
* Attention
* Brain Waves
* Cortical Synchronization
* Humans
* Male
* Norepinephrine
* Reflex, Pupillary
|keywords=* cognitive aging
* locus coeruleus
* noradrenaline
* norepinephrine
* rhythmic neural activity
* selective attention
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7252473
}}
{{medline-entry
|title=Cellular senescence: from anti-cancer weapon to anti-aging target.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32060861
 
|mesh-terms=* Aging
* Animals
* Antineoplastic Agents
* Breast Neoplasms
* Cell Proliferation
* Cell Transformation, Neoplastic
* Cellular Senescence
* Cyclin-Dependent Kinases
* Drug Discovery
* Female
* Humans
* Piperazines
* Protein Kinase Inhibitors
* Pyridines
|keywords=* cancer
* cellular senescence
* healthy aging
* pro-senescence cancer therapy
* senolytic therapies
|full-text-url=https://sci-hub.do/10.1007/s11427-019-1629-6
}}
{{medline-entry
|title=Extra-mitochondrial citrate synthase initiates calcium oscillation and suppresses age-dependent sperm dysfunction.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31857692
 
|mesh-terms=* Aging
* Animals
* Calcium Signaling
* Citrate (si)-Synthase
* Citric Acid Cycle
* Female
* Infertility, Male
* Male
* Metabolome
* Mice
* Ovum
* Spermatozoa
 
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7096335
}}
{{medline-entry
|title=Pathogenesis of chronic obstructive pulmonary disease (COPD) induced by cigarette smoke.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31737341
 
 
|keywords=* Airway inflammation
* autophagy
* cellular senescence
* chronic obstructive pulmonary disease (COPD)
* necroptosis
* oxidative stress
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6831915
}}
{{medline-entry
|title=Possible Role of Amyloid Cross-Seeding in Evolvability and Neurodegenerative Disease.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31524179
 
|mesh-terms=* Aging
* Amyloidogenic Proteins
* Animals
* Biological Evolution
* Brain
* Female
* Humans
* Inheritance Patterns
* Models, Neurological
* Neurodegenerative Diseases
* Pregnancy
* Stress, Physiological
|keywords=* Alzheimer’s disease
* Parkinson’s disease
* amyloid cascade hypothesis
* amyloidogenic proteins
* antimicrobial protection model
* cross-seeding
* evolvability hypothesis
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6839461
}}
{{medline-entry
|title=Targeting p16-induced senescence prevents cigarette smoke-induced emphysema by promoting IGF1/Akt1 signaling in mice.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31428695
 
|mesh-terms=* Alveolar Epithelial Cells
* Animals
* Cell Proliferation
* Cellular Senescence
* Cyclin-Dependent Kinase Inhibitor p16
* Cytokines
* Emphysema
* Insulin-Like Growth Factor I
* Lung
* Mice, Inbred C57BL
* Models, Biological
* Promoter Regions, Genetic
* Proto-Oncogene Proteins c-akt
* Pulmonary Disease, Chronic Obstructive
* RNA, Messenger
* Signal Transduction
* Smoking
|keywords=* Molecular biology
* Senescence
* Stem cells
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6689060
}}
==CSF1R==
 
{{medline-entry
|title=[[CSF1R]] inhibitor PLX5622 and environmental enrichment additively improve metabolic outcomes in middle-aged female mice.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32007953
 
 
|keywords=* CSF1R
* adipose
* aging
* environmental enrichment
* microglia
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7041757
}}
{{medline-entry
|title=Modulation of Microglia by Voluntary Exercise or [[CSF1R]] Inhibition Prevents Age-Related Loss of Functional Motor Units.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31693894
 
|mesh-terms=* Aging
* Animals
* Cell Line
* Databases, Genetic
* Humans
* Induced Pluripotent Stem Cells
* Macrophages
* Male
* Mice
* Mice, Inbred C57BL
* Microglia
* Motor Neurons
* Muscle, Skeletal
* Neuromuscular Junction
* Neuronal Plasticity
* Physical Conditioning, Animal
* RNA-Seq
* Receptors, Granulocyte-Macrophage Colony-Stimulating Factor
* Spinal Cord
|keywords=* CSF1R inhibition
* aging
* exercise
* innervation
* microglia
* motor unit
* neuroinflammation
* neuromuscular junction
* neuromuscular system
* spinal cord
|full-text-url=https://sci-hub.do/10.1016/j.celrep.2019.10.003
}}
==CTCF==
 
{{medline-entry
|title=New targeted approaches for epigenetic age predictions.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32580727
 
 
|keywords=* Aging
* Amplicon sequencing
* Blood
* Buccal swabs
* CTCF
* DNA methylation
* Droplet digital PCR
* Epigenetic
* Human
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7315536
}}
==CTH==
 
{{medline-entry
|title=Anterior Cingulate Structure and Perfusion is Associated with Cerebrospinal Fluid Tau among Cognitively Normal Older Adult APOEɛ4 Carriers.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31743999
 
 
|keywords=* APOE
* Aging
* Alzheimer’s disease
* cerebral blood flow
* cognition
* cognitive decline
* grey matter
* magnetic resonance imaging
* tau proteins
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7310575
}}
==CTLA4==
 
{{medline-entry
|title=Horticultural Therapy Reduces Biomarkers of Immunosenescence and Inflammaging in Community-Dwelling Older Adults: A Feasibility Pilot Randomized Controlled Trial.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/33070170
 
 
|keywords=* CTLA-4
* Geroscience
* IL-6
* Immunosenescence
* Inflammaging
|full-text-url=https://sci-hub.do/10.1093/gerona/glaa271
}}
==CTRL==
 
{{medline-entry
|title=Aging reduces the maximal level of peripheral fatigue tolerable and impairs exercise capacity.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32966120
 
 
|keywords=* aging
* critical torque
* exercise performance
* group III/IV muscle afferents
* neuromuscular fatigue
|full-text-url=https://sci-hub.do/10.1152/ajpregu.00151.2020
}}
{{medline-entry
|title=miR-146a Plasma Levels Are Not Altered in Alzheimer's Disease but Correlate With Age and Illness Severity.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32009940
 
 
|keywords=* Alzheimer’s disease
* aging
* blood
* miR-146a
* microRNA
* plasma
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6978630
}}
{{medline-entry
|title=Centrally-mediated regulation of peripheral fatigue during knee extensor exercise and consequences on the force-duration relationship in older men.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31397211
 
 
|keywords=* Aging
* critical torque
* group III/IV muscle afferents
|full-text-url=https://sci-hub.do/10.1080/17461391.2019.1655099
}}
==CTSA==
 
{{medline-entry
|title=A [[CTSA]]-based consultation service to advance research on special and underserved populations.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/33244406
 
 
|keywords=* faculty development
* geriatrics
* grant review
* grant studio
* pediatrics
* peer review
* research consultation service
* special populations
* underrepresented minorities
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7681147
}}
==CTSB==
 
{{medline-entry
|title=Myocardial cathepsin D is downregulated in sudden cardiac death.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32176724
 
|mesh-terms=* Adult
* Aged
* Aged, 80 and over
* Aging
* Cathepsin D
* Death, Sudden, Cardiac
* Down-Regulation
* Female
* Humans
* Male
* Middle Aged
* Myocardium
* Substrate Specificity
 
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7075574
}}
==CX3CL1==
 
{{medline-entry
|title=Two forms of [[CX3CL1]] display differential activity and rescue cognitive deficits in [[CX3CL1]] knockout mice.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32410624
 
 
|keywords=* Aging
* CX3CL1
* Cognition
* Fractalkine
* Long-term potentiation
* Microglia
* Neurodegeneration
* Neurogenesis
* Neuroinflammation
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7227354
}}
==CX3CR1==
 
{{medline-entry
|title=Monocytes present age-related changes in phospholipid concentration and decreased energy metabolism.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32107839
 
 
|keywords=* DNA methylation
* aging
* glucose metabolism
* monocytes
* phosphatidylcholines
* transcriptome
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7189998
}}
{{medline-entry
|title=Muscle Injury Induces Postoperative Cognitive Dysfunction.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32066806
 
|mesh-terms=* Aging
* Animals
* Brain
* Brain-Derived Neurotrophic Factor
* CX3C Chemokine Receptor 1
* Cytokines
* Disease Models, Animal
* Hippocampus
* Humans
* Male
* Mice
* Microglia
* Muscle, Skeletal
* Nerve Growth Factor
* Postoperative Cognitive Complications
* Postoperative Complications
 
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7026159
}}
==CXCL1==
 
{{medline-entry
|title=Contusion spinal cord injury upregulates p53 protein expression in rat soleus muscle at multiple timepoints but not key senescence cytokines.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32026570
 
 
|keywords=* SASP
* cytokines
* inflammation
* paralysis
* senescence
* spinal cord injury
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7002538
}}
{{medline-entry
|title=Systemic Inflammation and the Increased Risk of Inflamm-Aging and Age-Associated Diseases in People Living With HIV on Long Term Suppressive Antiretroviral Therapy.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31507593
 
|mesh-terms=* Adult
* Aging
* Anti-HIV Agents
* Antiretroviral Therapy, Highly Active
* Biomarkers
* CD4 Lymphocyte Count
* Computational Biology
* Cross-Sectional Studies
* Disease Susceptibility
* Duration of Therapy
* Female
* HIV Infections
* Humans
* Inflammation
* Male
* Metabolome
* Metabolomics
* Middle Aged
* Proteomics
* Telomere Homeostasis
* Viral Load
|keywords=* HIV
* India
* LMIC (lower middle income country)
* inflammation markers
* long term antiretroviral therapy
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6718454
}}
==CXCL10==
 
{{medline-entry
|title=Age-related decline of interferon-gamma responses in macrophage impairs satellite cell proliferation and regeneration.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32725722
 
 
|keywords=* Aging
* CXCL10
* IFN-γ
* Macrophage
* Muscle regeneration
* Single-cell RNA sequence
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7567146
}}
==CXCL11==
 
{{medline-entry
|title=Endothelial cells under therapy-induced senescence secrete [[CXCL11]], which increases aggressiveness of breast cancer cells.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32659248
 
 
|keywords=* CXCL11
* Endothelial cells
* Therapy-induced senescence
* Tumor microenvironment
|full-text-url=https://sci-hub.do/10.1016/j.canlet.2020.06.019
}}
==CXCL12==
 
{{medline-entry
|title=Co-option of Neutrophil Fates by Tissue Environments.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/33098771
 
 
|keywords=* angiogenesis
* immune heterogeneity
* immune niche
* innate immunity
* neutrophil lifespan
* neutrophils
* single-cell analysis
* tissue-resident cells
|full-text-url=https://sci-hub.do/10.1016/j.cell.2020.10.003
}}
{{medline-entry
|title=Heme oxygenase-1 deficiency triggers exhaustion of hematopoietic stem cells.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31885181
 
 
|keywords=* aging
* bone marrow
* cxcl12-abudant reticular cells
* endothelial cells
* niche
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7001511
}}
{{medline-entry
|title=Global Transcriptomic Profiling of the Bone Marrow Stromal Microenvironment during Postnatal Development, Aging, and Inflammation.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31801092
 
|mesh-terms=* Aging
* Animals
* Bone Marrow
* Bone Marrow Cells
* Cell Differentiation
* Cells, Cultured
* Cellular Microenvironment
* Chemokine CXCL12
* Embryonic Development
* Endothelial Cells
* Gene Expression Profiling
* Hematopoiesis
* Hematopoietic Stem Cells
* Inflammation
* Male
* Mesenchymal Stem Cells
* Mice
* Mice, Inbred C57BL
* Stem Cell Niche
* Transcriptome
|keywords=* aging
* bone marrow microenvironment
* hematopoietic stem cells
* inflammation
* niches
* stromal cells
* transcriptomics
|full-text-url=https://sci-hub.do/10.1016/j.celrep.2019.11.004
}}
==CXCL13==
 
{{medline-entry
|title=RNA-seq data from C-X-C chemokine receptor type 5 (CXCR5) gene knockout aged mice with retinal degeneration phenotype.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32642521
 
 
|keywords=* CXCR5
* FastQC
* RNA-Seq
* aging
* choroid
* mice
* retina
* retinal degeneration
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7334305
}}
==CXCL14==
 
{{medline-entry
|title=Identification of genes associated with endometrial cell aging.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/33258951
 
 
|keywords=* CXCL12
* CXCL14
* IL17RB
* endometrial cell aging
* infertility
* quantitative
immunohistochemistry
|full-text-url=https://sci-hub.do/10.1093/molehr/gaaa078
}}
==CXCL8==
 
{{medline-entry
|title=Cerebrovascular Senescence Is Associated With Tau Pathology in Alzheimer's Disease.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/33041998
 
 
|keywords=* Alzheimer's disease
* endothelial senescence
* gene expression
* neurofibrillary tangles
* plasma biomarkers
* tau pathology
* vascular dysfunction
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7525127
}}
==CXCL9==
 
{{medline-entry
|title=[[CXCL9]] and CXCL10 display an age-dependent profile in Chagas patients: a cohort study of aging in Bambui, Brazil.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32393333
 
|mesh-terms=* Aged
* Aged, 80 and over
* Aging
* Biomarkers
* Brazil
* Chagas Disease
* Chemokine CXCL10
* Chemokine CXCL9
* Cohort Studies
* Electrocardiography
* Female
* Humans
* Male
* Middle Aged
* Trypanosoma cruzi
|keywords=* Chagas disease
* Chemokines
* Cohort
* Cytokines
* Immune biomarkers
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7216412
}}
==CXCR2==
 
{{medline-entry
|title=CXCL5-[[CXCR2]] signaling is a senescence-associated secretory phenotype in preimplantation embryos.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32959976
 
 
|keywords=* CXCL5
* CXCR2
* SASP
* aging
* infertility
* preimplantation embryo
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7576282
}}
{{medline-entry
|title=Senescence in Wound Repair: Emerging Strategies to Target Chronic Healing Wounds.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32850866
 
 
|keywords=* ageing
* diabetes
* senescence
* senolytics
* wound healing
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7431694
}}
==CXCR3==
 
{{medline-entry
|title=Senescent hepatocytes enhance natural killer cell activity via the CXCL-10/[[CXCR3]] axis.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31616512
 
 
|keywords=* chemokine
* hepatocyte
* natural killer cell
* senescence
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6781833
}}
==CXCR4==
 
{{medline-entry
|title=Aging-Related Reduced Expression of [[CXCR4]] on Bone Marrow Mesenchymal Stromal Cells Contributes to Hematopoietic Stem and Progenitor Cell Defects.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32418119
 
 
|keywords=* Aging
* CXCR4 and ROS
* HSPC
* MSC
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7395885
}}
{{medline-entry
|title=Transfer of a human gene variant associated with exceptional longevity improves cardiac function in obese type 2 diabetic mice through induction of the SDF-1/[[CXCR4]] signalling pathway.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32384208
 
 
|keywords=* BPIFB4
* Cardiomyopathy
* Diabetes
* Gene therapy
* Longevity
|full-text-url=https://sci-hub.do/10.1002/ejhf.1840
}}
{{medline-entry
|title=Stromal Cell-Derived Factor 1 Protects Brain Vascular Endothelial Cells from Radiation-Induced Brain Damage.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31658727
 
|mesh-terms=* Animals
* Blood Vessels
* Brain
* Cell Line
* Cellular Senescence
* Chemokine CXCL12
* Cranial Irradiation
* Disease Models, Animal
* Down-Regulation
* Endothelial Cells
* Female
* Gene Expression Regulation
* Humans
* Lipopeptides
* Mice
* Receptors, CXCR4
* Signal Transduction
|keywords=* CXCR4
* SDF-1
* brain disorder
* endothelial dysfunction
* ionizing radiation
* senescence
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6830118
}}
==CYP11B1==
 
{{medline-entry
|title=Intratumoral heterogeneity of the tumor cells based on in situ cortisol excess in cortisol-producing adenomas; ∼An association among morphometry, genotype and cellular senescence∼.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/33002589
 
 
|keywords=* CYP11B1
* CYP17A
* Cellular senescence
* Compact and clear cells
* Cortisol-producing adenoma
* PRKACA
|full-text-url=https://sci-hub.do/10.1016/j.jsbmb.2020.105764
}}
==CYP1A1==
 
{{medline-entry
|title=Genome-wide scan identified genetic variants associated with skin aging in a Chinese female population.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31522824
 
|mesh-terms=* Adult
* Aged
* Aged, 80 and over
* Asian Continental Ancestry Group
* Cheek
* Cohort Studies
* Cytochrome P-450 CYP1A1
* European Continental Ancestry Group
* Female
* Genome-Wide Association Study
* Humans
* Middle Aged
* Polymorphism, Single Nucleotide
* Risk Factors
* Skin Aging
* Skin Pigmentation
|keywords=* Candidate SNPs
* Chinese Han females
* GWAS
* Skin aging
|full-text-url=https://sci-hub.do/10.1016/j.jdermsci.2019.08.010
}}
==CYP26B1==
 
{{medline-entry
|title=Increased Retinoic Acid Catabolism in Olfactory Sensory Neurons Activates Dormant Tissue-Specific Stem Cells and Accelerates Age-Related Metaplasia.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32385093
 
|mesh-terms=* Aging
* Animals
* Female
* Isotretinoin
* Male
* Metaplasia
* Mice
* Neural Stem Cells
* Neurogenesis
* Olfactory Mucosa
* Olfactory Receptor Neurons
* Retinoic Acid 4-Hydroxylase
|keywords=* aging
* inositol-1,4,5-triphosphate
* metaplasia
* olfactory epithelium
* retinoic acid
* stem cells
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7244205
}}
==CYP2C19==
 
{{medline-entry
|title=Physiologically Based Pharmacokinetic Approach Can Successfully Predict Pharmacokinetics of Citalopram in Different Patient Populations.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31750550
 
 
|keywords=* citalopram
* genetic polymorphism
* geriatrics
* physiologically based pharmacokinetic modeling
|full-text-url=https://sci-hub.do/10.1002/jcph.1541
}}
{{medline-entry
|title=Longitudinal exposure of English primary care patients to pharmacogenomic drugs: An analysis to inform design of pre-emptive pharmacogenomic testing.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31454087
 
|mesh-terms=* Aged
* Aged, 80 and over
* Aging
* Cytochrome P-450 CYP2C19
* Cytochrome P-450 CYP2D6
* Drug Prescriptions
* Female
* Humans
* Liver-Specific Organic Anion Transporter 1
* Longitudinal Studies
* Male
* Middle Aged
* Pharmaceutical Preparations
* Pharmacogenomic Testing
* Precision Medicine
* Primary Health Care
* United Kingdom
|keywords=* clinical pharmacology
* general practice
* pharmacogenomics
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6955399
}}
==CYP2E1==
 
{{medline-entry
|title=DNA methylation and histone acetylation changes to cytochrome P450 2E1 regulation in normal aging and impact on rates of drug metabolism in the liver.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32221779
 
 
|keywords=* Aging
* Cyp2e1
* DNA methylation
* Drug metabolism
* Histone acetylation
* Pharmacokinetics
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7287002
}}
==CYP7A1==
 
{{medline-entry
|title=Age-associated changes of cytochrome P450 and related phase-2 gene/proteins in livers of rats.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31396457
 
 
|keywords=* Aging
* Cytochrome P450’s
* Nuclear receptors
* Ontogeny
* Rat liver
* mRNA/protein expression
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6681801
}}
==DBI==
 
{{medline-entry
|title=Quantifying cumulative anticholinergic and sedative drug load among US Medicare Beneficiaries.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/33000867
 
 
|keywords=* aging
* cholinergic antagonists
* drug burden index
* drug utilization
* hypnotics and sedatives
* inappropriate prescribing
* pharmacoepidemiology
|full-text-url=https://sci-hub.do/10.1002/pds.5144
}}
{{medline-entry
|title=Drug Burden Index and Cognitive and Physical Function in Aged Care Residents: A Longitudinal Study.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32736845
 
 
|keywords=* Cognitive function
* anti-muscarinics
* benzodiazepines
* geriatrics
* longitudinal
* mobility impairment
* physical function
* polypharmacy
|full-text-url=https://sci-hub.do/10.1016/j.jamda.2020.05.037
}}
{{medline-entry
|title=Using the Drug Burden Index to identify older adults at highest risk for medication-related falls.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32532276
 
 
|keywords=* Accidental falls
* Aging
* Health services
* Medication
* Medication therapy management
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7291506
}}
{{medline-entry
|title=Impact of STEADI-Rx: A Community Pharmacy-Based Fall Prevention Intervention.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32315461
 
 
|keywords=* aging
* community pharmacy
* falls
* health services
* medication
|full-text-url=https://sci-hub.do/10.1111/jgs.16459
}}
==DBP==
 
{{medline-entry
|title=Do baseline blood pressure and type of exercise influence level of reduction induced by training in hypertensive older adults? A meta-analysis of controlled trials.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32795629
 
 
|keywords=* Aged
* Aging
* Exercise
* Exercise therapy
* High blood pressure
* Hypertension
* Resistance training
|full-text-url=https://sci-hub.do/10.1016/j.exger.2020.111052
}}
{{medline-entry
|title=Attenuated aortic blood pressure responses to metaboreflex activation in older adults with dynapenia.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32502600
 
 
|keywords=* Aging
* Diastolic pressure
* Handgrip strength
* Post-exercise muscle ischemia
* Walking performance
|full-text-url=https://sci-hub.do/10.1016/j.exger.2020.110984
}}
{{medline-entry
|title=The Effect of Blood Pressure on Cognitive Performance. An 8-Year Follow-Up of the Tromsø Study, Comprising People Aged 45-74 Years.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32373010
 
 
|keywords=* aging
* blood pressure
* cognitive performance
* dementia
* sex differences
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7186429
}}
{{medline-entry
|title=Low Diastolic Blood Pressure and Cognitive Decline in Korean Elderly People: The Korean Longitudinal Study on Cognitive Aging and Dementia.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31995969
 
 
|keywords=* Cognition
* Diastolic blood pressure
* Senility
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6992855
}}
{{medline-entry
|title=Diastolic Blood Pressure Is Associated With Regional White Matter Lesion Load: The Northern Manhattan Study.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31910743
 
|mesh-terms=* Aged
* Arterial Pressure
* Blood Pressure
* Brain
* Cohort Studies
* Diastole
* Female
* Frontal Lobe
* Humans
* Hypertension
* Linear Models
* Magnetic Resonance Imaging
* Male
* Middle Aged
* Organ Size
* Parietal Lobe
* Prospective Studies
* Systole
* Temporal Lobe
* White Matter
|keywords=* American Heart Association
* blood pressure
* cerebrovascular disease
* cognitive aging
* white matter
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7219602
}}
{{medline-entry
|title=Orthostatic Hypotension and Novel Blood Pressure Associated Gene Variants in Older Adults: Data From the TILDA Study.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31821404
 
 
|keywords=* Aging
* Blood pressure
* Cardiovascular
* Genetics
* Single-nucleotide polymorphism
|full-text-url=https://sci-hub.do/10.1093/gerona/glz286
}}
{{medline-entry
|title=Blood pressure and hypertension prevalence among oldest-old in China for 16 year: based on CLHLS.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31500574
 
|mesh-terms=* Aged, 80 and over
* Blood Pressure
* Blood Pressure Determination
* China
* Female
* Health Surveys
* Humans
* Hypertension
* Longevity
* Longitudinal Studies
* Male
* Prevalence
|keywords=* Blood pressure
* Epidemiology
* Hypertension
* Oldest-old
* Prevalence
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6734230
}}
{{medline-entry
|title=The age-related blood pressure trajectories from young-old adults to centenarians: A cohort study.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31443986
 
|mesh-terms=* Age Factors
* Aged
* Aged, 80 and over
* Aging
* Blood Pressure
* Cohort Studies
* Female
* Humans
* Male
* Middle Aged
|keywords=* Antihypertensive therapy
* Birth cohort effect
* Blood pressure
* Cohort study
* Heart disease
* Survival
|full-text-url=https://sci-hub.do/10.1016/j.ijcard.2019.08.011
}}
==DCC==
 
{{medline-entry
|title=X Chromosome Domain Architecture Regulates Caenorhabditis elegans Lifespan but Not Dosage Compensation.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31495695
 
|mesh-terms=* Adenosine Triphosphatases
* Animals
* Caenorhabditis elegans
* Caenorhabditis elegans Proteins
* DNA-Binding Proteins
* Dosage Compensation, Genetic
* Gene Expression Regulation
* Longevity
* Multiprotein Complexes
* X Chromosome
|keywords=* X chromosome dosage compensation
* aging
* condensin
* gene expression
* higher-order chromosome structure
* lifespan
* proteotoxic stress
* topologically associating domains
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6810858
}}
==DCN==
 
{{medline-entry
|title=Decorin inhibits the insulin-like growth factor I signaling in bone marrow mesenchymal stem cells of aged humans.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/33257596
 
 
|keywords=* IGF-I
* aging
* bone marrow mesenchymal stem cell
* osteoporosis
* small leucine-rich proteoglycan
|full-text-url=https://sci-hub.do/10.18632/aging.202166
}}
==DCX==
 
{{medline-entry
|title=GSK-3β activation accelerates early-stage consumption of Hippocampal Neurogenesis in senescent mice.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32863953
 
 
|keywords=* Adult hippocampal neurogenesis
* Glycogen synthase kinase-3β
* Senescence
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7449917
}}
{{medline-entry
|title=Doublecortin and IGF-1R protein levels are reduced in spite of unchanged DNA methylation in the hippocampus of aged rats.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32236698
 
 
|keywords=* Aging
* DNA methylation
* Doublecortin
* Hippocampus
* IGF-1R
* mGluR5
|full-text-url=https://sci-hub.do/10.1007/s00726-020-02834-3
}}
==DDB1==
 
{{medline-entry
|title=DCAF1 regulates Treg senescence via the ROS axis during immunological aging.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32730228
 
 
|keywords=* Aging
* Cellular senescence
* Immunology
* Inflammatory bowel disease
* T cells
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7598062
}}
==DDC==
 
{{medline-entry
|title=N-Acetyl Cysteine Attenuates the Sarcopenia and Muscle Apoptosis Induced by Chronic Liver Disease.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31530262
 
|mesh-terms=* Acetylcysteine
* Aging
* Animals
* Apoptosis
* Disease Models, Animal
* End Stage Liver Disease
* Humans
* Mice
* Muscle Fibers, Skeletal
* Muscular Atrophy
* Oxidative Stress
* Pyridines
* Sarcopenia
|keywords=* Sarcopenia
* UPP oxidative stress
* apoptosis
* chronic liver disease
* hepatotoxin.
|full-text-url=https://sci-hub.do/10.2174/1566524019666190917124636
}}
==DDO==
 
{{medline-entry
|title=New insights on the influence of free d-aspartate metabolism in the mammalian brain during prenatal and postnatal life.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32561430
 
 
|keywords=* Brain aging
* Cell death
* L-Glutamate
* NMDA receptors
* d-Aspartate
* d-Aspartate oxidase
|full-text-url=https://sci-hub.do/10.1016/j.bbapap.2020.140471
}}
==DDT==
 
{{medline-entry
|title=Prognostic Value of a Test of Central Auditory Function in Conversion from Mild Cognitive Impairment to Dementia.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32388503
 
 
|keywords=* Aging
* Alzheimer’s disease
* Auditory processing
* Cognition
* Dichotic Digits Test
|full-text-url=https://sci-hub.do/10.1159/000506621
}}
{{medline-entry
|title=Uptake kinetics of four hydrophobic organic pollutants in the earthworm Eisenia andrei in aged laboratory-contaminated natural soils.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32061977
 
|mesh-terms=* Animals
* DDT
* Hexachlorocyclohexane
* Hydrophobic and Hydrophilic Interactions
* Kinetics
* Oligochaeta
* Polychlorinated Biphenyls
* Pyrenes
* Soil Pollutants
|keywords=* Aging
* BAFs
* Bioaccumulation
* HOCs
* Laboratory-contaminated soils
|full-text-url=https://sci-hub.do/10.1016/j.ecoenv.2020.110317
}}
{{medline-entry
|title=Adult exposure to insecticides causes persistent behavioral and neurochemical alterations in zebrafish.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31911208
 
 
|keywords=* Aging
* Anxiety-related behavior
* DDT
* Neurobehavioral toxicology
* Zebrafish
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7061078
}}
{{medline-entry
|title=Second generation effects of larval metal pollutant exposure on reproduction, longevity and insecticide tolerance in the major malaria vector Anopheles arabiensis (Diptera: Culicidae).
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31910892
 
|mesh-terms=* Animals
* Anopheles
* Drug Resistance
* Female
* Fertility
* Insecticides
* Larva
* Male
* Metals
* Reproduction
* Water Pollutants
|keywords=* Anopheles arabiensis
* Insecticide resistance
* Longevity
* Transgenerational effects
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6947826
}}
{{medline-entry
|title=Protective effect of Pedro-Ximénez must against p,p'-DDE-induced liver damages in aged Mus spretus mice.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31765701
 
|mesh-terms=* Aging
* Animals
* Antioxidants
* Chemical and Drug Induced Liver Injury
* Dichlorodiphenyl Dichloroethylene
* Down-Regulation
* Liver
* Male
* Mice
* Oxidative Stress
* Pesticides
* Plant Extracts
* Polyphenols
* Transcriptome
* Up-Regulation
* Vitis
|keywords=* Aging
* Hepatoprotection
* Mus spretus
* Organochlorine
* Oxidative damage
* Pedro-ximénez grape must
* Transcriptional analysis
* p,p'-DDE
|full-text-url=https://sci-hub.do/10.1016/j.fct.2019.110984
}}
{{medline-entry
|title=Low-dose endosulfan inhibits proliferation and induces senescence and pro-inflammatory cytokine production in human lymphocytes, preferentially impacting cytotoxic cells.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31589084
 
|mesh-terms=* Adult
* B-Lymphocytes
* Cell Proliferation
* Cells, Cultured
* Cellular Senescence
* Cytokines
* Dose-Response Relationship, Drug
* Endosulfan
* Female
* Healthy Volunteers
* Humans
* Inflammation Mediators
* Insecticides
* Killer Cells, Natural
* Male
* Primary Cell Culture
* T-Lymphocytes, Cytotoxic
* Young Adult
|keywords=* Endosulfan
* Immunosenescence
* NK cells
* PBMC
* cytotoxic cells
* interferon
* organochlorine pesticide
* senescence
|full-text-url=https://sci-hub.do/10.1080/1547691X.2019.1668513
}}
==DKC1==
 
{{medline-entry
|title=Successful liver transplantation in short telomere syndromes without bone marrow failure due to [[DKC1]] mutation.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32166868
 
 
|keywords=* DKC1
* cell death: senescence
* cirrhosis
* hepatopulmonary syndrome
* liver transplantation
* short telomere syndromes
|full-text-url=https://sci-hub.do/10.1111/petr.13695
}}
==DLD==
 
{{medline-entry
|title=A preliminary study of cerebral blood flow, aging and dementia in people with Down syndrome.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32996650
 
 
|keywords=* Alzheimer's disease
* Down syndrome
* aging
* cerebral blood flow
* neuroimaging
|full-text-url=https://sci-hub.do/10.1111/jir.12784
}}
==DLGAP2==
 
{{medline-entry
|title=Cross-Species Analyses Identify Dlgap2 as a Regulator of Age-Related Cognitive Decline and Alzheimer's Dementia.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32877673
 
 
|keywords=* Alzheimer’s
* Diversity Outbred
* Dlgap2
* GWAS
* aging
* cognition
* genetic diversity
* resilience
* spines
* susceptibility
* translational
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7502175
}}
==DLX5==
 
{{medline-entry
|title=Inhibition of microRNA-27b-3p relieves osteoarthritis pain via regulation of KDM4B-dependent [[DLX5]].
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32856377
 
 
|keywords=* adipogenic differentiation
* cell senescence
* distal-less homeobox 5
* lysine demethylase 4B
* mesenchymal stem cells
* microRNA-27b-3p
* osteoarthritis pain
* osteogenic differentiation
|full-text-url=https://sci-hub.do/10.1002/biof.1670
}}
==DMD==
 
{{medline-entry
|title=Aldehyde dehydrogenases contribute to skeletal muscle homeostasis in healthy, aging, and Duchenne muscular dystrophy patients.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32157826
 
 
|keywords=* Aging
* Aldehyde dehydrogenase
* Dog model
* Duchenne muscular dystrophy
* Human
* Myogenic
* Non-human primate
* Skeletal muscle
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7432589
}}
{{medline-entry
|title=Life expectancy at birth in Duchenne muscular dystrophy: a systematic review and meta-analysis.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32107739
 
|mesh-terms=* Female
* Humans
* Life Expectancy
* Male
* Muscular Dystrophy, Duchenne
* Parturition
* Pregnancy
* Prognosis
* Quality of Life
* Respiration, Artificial
* Survival
|keywords=* Mechanical ventilation
* Mortality
* Prognosis
* Survival
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7387367
}}
{{medline-entry
|title=Renal dysfunction can occur in advanced-stage Duchenne muscular dystrophy.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31725904
 
|mesh-terms=* Adolescent
* Adult
* Aging
* Child
* Child, Preschool
* Cystatin C
* Disease Progression
* Female
* Heart Diseases
* Heart Function Tests
* Humans
* Kidney Diseases
* Kidney Function Tests
* Male
* Muscular Dystrophy, Duchenne
* Risk Factors
* Young Adult
|keywords=* Duchenne muscular dystrophy
* advanced stage
* cystatin C
* ejection fraction
* fractional shortening
* renal dysfunction
|full-text-url=https://sci-hub.do/10.1002/mus.26757
}}
==DNAJB9==
 
{{medline-entry
|title=[[DNAJB9]] Inhibits p53-Dependent Oncogene-Induced Senescence and Induces Cell Transformation.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32264658
 
 
|keywords=* DNAJB9
* RAS
* p53
* senescence
* transformation
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7191047
}}
==DNMT1==
 
{{medline-entry
|title=DNA Methyltransferase 1 ([[DNMT1]]) Function Is Implicated in the Age-Related Loss of Cortical Interneurons.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32793592
 
 
|keywords=* DNA methylation
* GABA
* aging
* cerebral cortex
* inhibitory interneurons
* proteostasis
* synapse
* transcriptional control
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7387673
}}
==DNMT3A==
 
{{medline-entry
|title=Epigenetic regulation of miR-29a/miR-30c/[[DNMT3A]] axis controls SOD2 and mitochondrial oxidative stress in human mesenchymal stem cells.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32961441
 
 
|keywords=* Cellular senescence
* DNMT3A
* Human mesenchymal stem cells
* Mitochondrial oxidative stress
* SOD2
* microRNAs
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7509080
}}
{{medline-entry
|title=Collagens and DNA methyltransferases in mare endometrosis.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31512314
 
|mesh-terms=* Aging
* Animals
* Collagen
* DNA (Cytosine-5-)-Methyltransferases
* DNA Methylation
* Endometritis
* Endometrium
* Female
* Fibrosis
* Horse Diseases
* Horses
* RNA, Messenger
|keywords=* DNA methylation
* collagen
* endometrium
* epigenetic
* fibrosis
* mare
|full-text-url=https://sci-hub.do/10.1111/rda.13515
}}
{{medline-entry
|title=Age-related clonal haemopoiesis is associated with increased epigenetic age.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31430471
 
|mesh-terms=* Aged
* Aged, 80 and over
* Aging
* Epigenesis, Genetic
* Female
* Hematopoiesis
* Humans
* Longitudinal Studies
* Male
* Risk Factors
* Scotland
 
|full-text-url=https://sci-hub.do/10.1016/j.cub.2019.07.011
}}
==DNMT3L==
 
{{medline-entry
|title=Transient [[DNMT3L]] Expression Reinforces Chromatin Surveillance to Halt Senescence Progression in Mouse Embryonic Fibroblast.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32195249
 
 
|keywords=* DNA methyltransferase 3-like (DNMT3L)
* chromatin surveillance
* epigenetics
* polycomb repressive complex 2 (PRC2)
* senescence
* transposable element (TE)
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7064442
}}
==DOCK11==
 
{{medline-entry
|title=[Immunosenescence: The Forefront of Infection and Trophic Control].
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32115558
 
|mesh-terms=* Aging
* Animals
* B-Lymphocytes
* Cytokinesis
* Gene Expression
* Guanine Nucleotide Exchange Factors
* Humans
* Immunoglobulin M
* Immunosenescence
* Mice
* Nutritional Status
* Streptococcus pneumoniae
|keywords=* B-1a B cell
* dedicator of cytokinesis 11
* immunosenescence
|full-text-url=https://sci-hub.do/10.1248/yakushi.19-00193-3
}}
==DPP4==
 
{{medline-entry
|title=Age-Dependent Assessment of Genes Involved in Cellular Senescence, Telomere, and Mitochondrial Pathways in Human Lung Tissue of Smokers, COPD, and IPF: Associations With SARS-CoV-2 COVID-19 ACE2-TMPRSS2-Furin-[[DPP4]] Axis.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/33013423
 
 
|keywords=* DNA damage
* aging
* cellular senescence
* chronic obstructive pulmonary diseases
* idiopathic pulmonary fibrosis
* mitochondria
* smokers
* telomere
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7510459
}}
{{medline-entry
|title=Dipeptidyl peptidase-4 inhibition improves endothelial senescence by activating AMPK/SIRT1/Nrf2 signaling pathway.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32251672
 
 
|keywords=* Aging
* Dipeptidyl peptidase-4
* Endothelium
* Oxidative stress
* Vascular
|full-text-url=https://sci-hub.do/10.1016/j.bcp.2020.113951
}}
{{medline-entry
|title=Molecular crosstalk between Y5 receptor and neuropeptide Y drives liver cancer.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31999643
 
 
|keywords=* Aging
* Cancer
* Hepatology
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7190991
}}
==DPP6==
 
{{medline-entry
|title=A novel structure associated with aging is augmented in the [[DPP6]]-KO mouse brain.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/33225987
 
 
|keywords=* Aging dementia
* Alzheimer’s disease
* DPP6
* Presynaptic terminals
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7682109
}}
==DPYSL2==
 
{{medline-entry
|title=Alcohol drinking exacerbates neural and behavioral pathology in the 3xTg-AD mouse model of Alzheimer's disease.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31733664
 
|mesh-terms=* Alcohol Drinking
* Alzheimer Disease
* Amyloid beta-Protein Precursor
* Animals
* Behavior, Animal
* Brain
* Disease Models, Animal
* Mice, Transgenic
* tau Proteins
|keywords=* Aging
* Amyloid beta
* Ethanol
* GSK
* Immunohistochemistry
* Morris Water Maze
* Prepulse inhibition
* Self-administration
* Tau pathology
* Transgenic mouse model
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6939615
}}
==DRD1==
 
{{medline-entry
|title=Impact of dopamine-related genetic variants on physical activity in old age - a cohort study.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32448293
 
|mesh-terms=* Aged
* Aged, 80 and over
* Aging
* Cohort Studies
* Exercise
* Humans
* Receptors, Dopamine
* Sedentary Behavior
* Sweden
|keywords=* Accelerometery
* Aging
* Dopamine
* Genes
* Physical activity
* Sedentary behaviour
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7245799
}}
==DRD2==
 
{{medline-entry
|title=Cortical thickness mediates the relationship between [[DRD2]] C957T polymorphism and executive function across the adult lifespan.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/33179159
 
 
|keywords=* Aging
* Cortical thickness
* DRD2
* Dopamine
* Executive function
|full-text-url=https://sci-hub.do/10.1007/s00429-020-02169-5
}}
{{medline-entry
|title=The relationship of age and [[DRD2]] polymorphisms to frontostriatal brain activity and working memory performance.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31629117
 
|mesh-terms=* Aging
* Brain
* Humans
* Memory, Short-Term
* Polymorphism, Genetic
* Receptors, Dopamine D2
|keywords=* Aging
* C957T
* DRD2
* Dopamine
* Working memory
* fMRI
|full-text-url=https://sci-hub.do/10.1016/j.neurobiolaging.2019.08.022
}}
==DSPP==
 
{{medline-entry
|title=Effects of [i]p[/i]-Cresol on Senescence, Survival, Inflammation, and Odontoblast Differentiation in Canine Dental Pulp Stem Cells.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32967298
 
 
|keywords=* aged teeth
* apoptosis
* dental pulp stem cells
* differentiation
* pulp regeneration
* senescence
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7555360
}}
==DST==
 
{{medline-entry
|title=Ancestral germen/soma distinction in microbes: Expanding the disposable soma theory of aging to all unicellular lineages.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32268207
 
|mesh-terms=* Aging
* Animals
* Biological Evolution
* DNA Replication
* Humans
* Phylogeny
|keywords=* Aging
* Asymmetric cell division
* DNA replication
* Disposable Soma Theory
* Epigenetics
* Evolution
* Germen/Soma
* Prokaryotes
* Protists
* Rejuvenation
* Unicellular
|full-text-url=https://sci-hub.do/10.1016/j.arr.2020.101064
}}
==DUSP1==
 
{{medline-entry
|title=miR-1468-3p Promotes Aging-Related Cardiac Fibrosis.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32348937
 
 
|keywords=* aging
* cardiac fibrosis
* dual-specificity phosphatases
* extracellular matrix
* miR-1468-3p
* microRNA
* p38
* senescence
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7191129
}}
==DUSP8==
 
{{medline-entry
|title=MiR-21-5p/dual-specificity phosphatase 8 signalling mediates the anti-inflammatory effect of haem oxygenase-1 in aged intracerebral haemorrhage rats.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31400088
 
|mesh-terms=* Aging
* Animals
* Antagomirs
* Anti-Inflammatory Agents
* Cells, Cultured
* Cerebral Hemorrhage
* Dual-Specificity Phosphatases
* HEK293 Cells
* Heme Oxygenase-1
* Hemin
* Humans
* Male
* MicroRNAs
* Rats
* Rats, Sprague-Dawley
* Signal Transduction
|keywords=* aging
* dual-specificity phosphatase 8
* haem oxygenase-1
* intracerebral haemorrhage
* microRNA
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6826124
}}
==DUT==
 
{{medline-entry
|title=Simultaneous liquefaction, saccharification, and fermentation of L-lactic acid using aging paddy rice with hull by an isolated thermotolerant Enterococcus faecalis [[DUT]]1805.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32388689
 
 
|keywords=* Aging paddy rice with hull (APRH)
* Corn steep liquor powder (CSLP)
* High-thermotolerance
* Lactic acid
* Saccharification and fermentation (SLSF)
* Simultaneous liquification
|full-text-url=https://sci-hub.do/10.1007/s00449-020-02364-y
}}
==DYRK1A==
 
{{medline-entry
|title=Altered age-linked regulation of plasma [[DYRK1A]] in elderly cognitive complainers (INSIGHT-preAD study) with high brain amyloid load.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32642550
 
 
|keywords=* Alzheimer's disease
* aging
* blood marker
* immunometric test
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7331462
}}
==E2F1==
 
{{medline-entry
|title=Regulation of [[E2F1]] activity via PKA-mediated phosphorylations.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/33110360
 
 
|keywords=* E2F1
* PKA
* cell cycle
* forskolin
* proliferation
* senescence
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7585165
}}
{{medline-entry
|title=Astragaloside IV ameliorates radiation-induced senescence via antioxidative mechanism.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32412100
 
 
|keywords=* cell signal pathway
* nerve cells
* radiation
* senescence
|full-text-url=https://sci-hub.do/10.1111/jphp.13284
}}
==ECD==
 
{{medline-entry
|title=Outcome of Descemet Membrane Endothelial Keratoplasty Using Corneas from Donors ≥80 Years of Age.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31837315
 
|mesh-terms=* Adolescent
* Adult
* Aged
* Aged, 80 and over
* Aging
* Cell Count
* Cornea
* Descemet Stripping Endothelial Keratoplasty
* Donor Selection
* Endothelium, Corneal
* Female
* Fuchs' Endothelial Dystrophy
* Humans
* Male
* Middle Aged
* Retrospective Studies
* Tissue Donors
* Treatment Outcome
* Visual Acuity
* Young Adult
 
|full-text-url=https://sci-hub.do/10.1016/j.ajo.2019.12.001
}}
==EDA==
 
{{medline-entry
|title=Interplay between aging, lung inflammation/remodeling, and fibronectin [[EDA]] in lung cancer progression.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/33222614
 
 
|keywords=* Lung cancer
* aging
* fibronectin EDA
* fibrosis
* inflammation
* lewis lung carcinoma
* metastasis
|full-text-url=https://sci-hub.do/10.1080/15384047.2020.1831372
}}
{{medline-entry
|title=Arousal Detection in Elderly People from Electrodermal Activity Using Musical Stimuli.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32854302
 
 
|keywords=* aging adults
* arousal
* electrodermal activity
* musical genres
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7506973
}}
{{medline-entry
|title=The structure of agricultural microplastics (PT, PU and UF) and their sorption capacities for PAHs and PHE derivates under various salinity and oxidation treatments.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31761592
 
|mesh-terms=* Adsorption
* Agriculture
* Ecosystem
* Environmental Pollutants
* Hydrogen Peroxide
* Microplastics
* Models, Chemical
* Naphthalenes
* Organic Chemicals
* Phenanthrenes
* Plastics
* Polycyclic Aromatic Hydrocarbons
* Polyethylene
* Polypropylenes
* Polyurethanes
* Polyuria
* Pyrenes
* Salinity
|keywords=* Aging
* Microplastics
* Polycyclic aromatic hydrocarbons
* Salinity
* Sorption
|full-text-url=https://sci-hub.do/10.1016/j.envpol.2019.113525
}}
==EDARADD==
 
{{medline-entry
|title=Age prediction in living: Forensic epigenetic age estimation based on blood samples.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32721866
 
|mesh-terms=* Adolescent
* Adult
* Aged
* Aging
* Child
* Child, Preschool
* CpG Islands
* Cyclic Nucleotide Phosphodiesterases, Type 4
* DNA Methylation
* Edar-Associated Death Domain Protein
* Fatty Acid Elongases
* Female
* Forensic Genetics
* Humans
* Infant
* LIM-Homeodomain Proteins
* Male
* Middle Aged
* Muscle Proteins
* Polymerase Chain Reaction
* Transcription Factors
* Young Adult
|keywords=* Age the living
* CpGs
* DNA methylation age
* Forensic epigenetics
* Forensic sciences
|full-text-url=https://sci-hub.do/10.1016/j.legalmed.2020.101763
}}
==EDF1==
 
{{medline-entry
|title=Silencing of FOREVER YOUNG FLOWER Like Genes from Phalaenopsis Orchids Promotes Flower Senescence and Abscission.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/33237274
 
 
|keywords=*
          FOREVER YOUNG FLOWER
       
*
          Phalaenopsis orchids
* Abscission
* Ethylene responses
* MADS-box gene
* Senescence
|full-text-url=https://sci-hub.do/10.1093/pcp/pcaa145
}}
==EFS==
 
{{medline-entry
|title=The aging bladder phenotype is not the direct consequence of bladder aging.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31452236
 
|mesh-terms=* Adrenergic beta-Agonists
* Aging
* Animals
* Carbachol
* Cholinergic Agonists
* Electric Stimulation
* Female
* Isoproterenol
* Male
* Mice
* Mucous Membrane
* Muscle Contraction
* Myography
* Phenotype
* Receptor, Muscarinic M3
* Receptors, Adrenergic, beta-2
* Urinary Bladder
* Urination
|keywords=* aging
* control physiology
* resilience
* urinary dysfunction
|full-text-url=https://sci-hub.do/10.1002/nau.24149
}}
==EGF==
 
{{medline-entry
|title=Acute, exercise-induced alterations in cytokines and chemokines in the blood distinguish physically active and sedentary aging.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/33289019
 
 
|keywords=* growth factors
* human aging
* inflammation
* physical activity
|full-text-url=https://sci-hub.do/10.1093/gerona/glaa310
}}
{{medline-entry
|title=Proinflammation, profibrosis, and arterial aging.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/33103036
 
 
|keywords=* aging
* artery
* collagen
* profibrosis
* proinflammation
* stiffening
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7574637
}}
{{medline-entry
|title=Hinokitiol induces cell death and inhibits epidermal growth factor-induced cell migration and signaling pathways in human cervical adenocarcinoma.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32917321
 
 
|keywords=* Autophagy
* Epidermal growth factor
* Hinokitiol
* Senescence
* c-Jun N-Terminal kinase
|full-text-url=https://sci-hub.do/10.1016/j.tjog.2020.07.013
}}
{{medline-entry
|title=Activation of epidermal growth factor receptor signaling mediates cellular senescence induced by certain pro-inflammatory cytokines.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32323422
 
 
|keywords=* EGFR
* HUVEC
* IMR90
* Ras signaling
* pro-inflammatory cytokine
* senescence
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7253070
}}
{{medline-entry
|title=Insulin Signaling in Intestinal Stem and Progenitor Cells as an Important Determinant of Physiological and Metabolic Traits in [i]Drosophila[/i].
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32225024
 
 
|keywords=* ISC
* fruit fly
* insulin signaling pathway
* lifespan
* metabolism
* midgut
* progenitor cells
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7226132
}}
{{medline-entry
|title=Different cellular properties and loss of nuclear signalling of porcine epidermal growth factor receptor with aging.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32001323
 
|mesh-terms=* Animals
* ErbB Receptors
* Signal Transduction
* Swine
|keywords=* Aging
* Cell behaviour
* EGF
* EGFR
* Signalling pathway
|full-text-url=https://sci-hub.do/10.1016/j.ygcen.2020.113415
}}
==EGFR==
 
{{medline-entry
|title=Type I Collagen Aging Increases Expression and Activation of [[EGFR]] and Induces Resistance to Erlotinib in Lung Carcinoma in 3D Matrix Model.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/33014812
 
 
|keywords=* EGFR
* Erlotinib
* Type I collagen
* aging
* resistance
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7511549
}}
{{medline-entry
|title=Comparative effectiveness and cost-effectiveness of three first-line [[EGFR]]-tyrosine kinase inhibitors: Analysis of real-world data in a tertiary hospital in Taiwan.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32267879
 
|mesh-terms=* Afatinib
* Aged
* Carcinoma, Non-Small-Cell Lung
* Cost-Benefit Analysis
* Erlotinib Hydrochloride
* Female
* Gefitinib
* Humans
* Life Expectancy
* Lung Neoplasms
* Male
* Propensity Score
* Protein Kinase Inhibitors
* Quality of Life
* Survival Rate
* Taiwan
* Tertiary Care Centers
 
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7141611
}}
{{medline-entry
|title=An Optogenetic Method to Study Signal Transduction in Intestinal Stem Cell Homeostasis.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32201167
 
|mesh-terms=* Animals
* Cell Communication
* Cell Proliferation
* Cells, Cultured
* Drosophila Proteins
* Drosophila melanogaster
* Gene Expression Regulation
* Gene Regulatory Networks
* Homeostasis
* Intestinal Mucosa
* Light
* Longevity
* Optogenetics
* Signal Transduction
* Stem Cells
|keywords=* Drosophila
* EGFR
* Toll
* optogenetics
* stem cells
|full-text-url=https://sci-hub.do/10.1016/j.jmb.2020.03.019
}}
{{medline-entry
|title=Treatment-Induced Tumor Dormancy through YAP-Mediated Transcriptional Reprogramming of the Apoptotic Pathway.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31935369
 
|mesh-terms=* Adaptor Proteins, Signal Transducing
* Animals
* Apoptosis
* Cell Cycle Proteins
* Cell Line, Tumor
* Cell Proliferation
* Cell Survival
* Cellular Senescence
* Drug Resistance, Neoplasm
* ErbB Receptors
* Female
* Gene Deletion
* Gene Expression Regulation, Neoplastic
* Humans
* Lung Neoplasms
* MAP Kinase Kinase 1
* Male
* Mice
* Mice, Knockout
* Mutation
* Signal Transduction
* Transcription Factors
* Transcription, Genetic
|keywords=* YAP
* dormancy
* drug resistance
* drug tolerance
* epidermal growth factor receptor
* lung cancer
* senescence
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7146079
}}
{{medline-entry
|title=Association between [[EGFR]] mutation and ageing, history of pneumonia and gastroesophageal reflux disease among patients with advanced lung cancer.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31634646
 
|mesh-terms=* Adult
* Aged
* Aged, 80 and over
* Aging
* Case-Control Studies
* ErbB Receptors
* Female
* Gastroesophageal Reflux
* Humans
* Lung Neoplasms
* Male
* Middle Aged
* Mutation
* Pneumonia
* Republic of Korea
* Retrospective Studies
* Risk Factors
* Young Adult
|keywords=* Ageing
* EGFR mutation
* GERD
* Lung cancer
* Pneumonia
* Risk factors
|full-text-url=https://sci-hub.do/10.1016/j.ejca.2019.09.010
}}
==EHF==
 
{{medline-entry
|title=Extended high frequency hearing and speech perception implications in adults and children.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32111404
 
 
|keywords=* Aging
* Development
* Extended high frequency audiometry
* Otitis media
* Ototoxicity
* Speech in noise
* Speech perception
* Tinnitus
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7431381
}}
==EIF4E==
 
{{medline-entry
|title=Transcriptomic evidence that insulin signalling pathway regulates the ageing of subterranean termite castes.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32424344
 
|mesh-terms=* Aging
* Animals
* Insulin
* Isoptera
* Molecular Sequence Annotation
* Signal Transduction
* Transcriptome
 
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7235038
}}
==ELF3==
 
{{medline-entry
|title=High Ambient Temperature Accelerates Leaf Senescence via PHYTOCHROME-INTERACTING FACTOR 4 and 5 in [i]Arabidopsis[/i].
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32732458
 
 
|keywords=* Arabidopsis
* PIF4
* phytochrome
* senescence
* temperature
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7398796
}}
==ELOVL2==
 
{{medline-entry
|title=[[ELOVL2]]: Not just a biomarker of aging.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/33043173
 
 
|keywords=* Aging
* Macular degeneration
* Membrane structure
* Polyunsaturated fatty acids
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7544151
}}
{{medline-entry
|title=The lipid elongation enzyme [[ELOVL2]] is a molecular regulator of aging in the retina.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31943697
 
|mesh-terms=* Aging
* Animals
* Cell Line
* DNA Methylation
* Decitabine
* Down-Regulation
* Fatty Acid Elongases
* Fatty Acids, Unsaturated
* Female
* Humans
* Macular Degeneration
* Male
* Mice
* Mice, Transgenic
* Point Mutation
* Promoter Regions, Genetic
* Retina
* Retinal Pigment Epithelium
|keywords=* DNA methylation
* ELOVL2
* PUFA
* age-related macular degeneration
* aging
* retina
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6996962
}}
==EN1==
 
{{medline-entry
|title=Electrochemically detecting DNA methylation in the [[EN1]] gene promoter: implications for understanding ageing and disease.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/33135722
 
 
|keywords=* Aging
* biosensor
* electrochemistry
* methylation
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7670582
}}
==ENO1==
 
{{medline-entry
|title=Reduced expression of enolase-1 correlates with high intracellular glucose levels and increased senescence in cisplatin-resistant ovarian cancer cells.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32355541
 
 
|keywords=* ENO1
* Enolase
* beta-Gal
* cisplatin resistance
* glucose
* ovarian cancer
* p21
* p53
* senescence
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7191177
}}
==ENTPD7==
 
{{medline-entry
|title=Inhibition of lung cancer cells and Ras/Raf/MEK/ERK signal transduction by ectonucleoside triphosphate phosphohydrolase-7 ([[ENTPD7]]).
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31443651
 
|mesh-terms=* Adult
* Aged
* Animals
* Apoptosis
* Apyrase
* Biomarkers
* Cell Line, Tumor
* Cell Proliferation
* Cells, Cultured
* Female
* Gene Expression Regulation, Neoplastic
* Gene Silencing
* Humans
* Lung Neoplasms
* MAP Kinase Signaling System
* Male
* Mice
* Mice, Inbred BALB C
* Mice, Nude
* Middle Aged
* Mitogen-Activated Protein Kinases
* Plasmids
* Signal Transduction
* Survival Analysis
* raf Kinases
* ras Proteins
|keywords=* Ectonucleoside triphosphate phosphohydrolase-7
* Lung cancer
* Proliferation
* Senescence
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6708200
}}
==EPO==
 
{{medline-entry
|title=Regulation of muscle and metabolic physiology by hypothalamic erythropoietin independently of its peripheral action.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32029230
 
 
|keywords=* Aging
* Brain
* Erythropoietin
* Glucose tolerance
* Hypothalamus
* Metabolism
* Muscle
* Obesity
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6938905
}}
{{medline-entry
|title=Red Blood Cell Lifespan Shortening in Patients with Early-Stage Chronic Kidney Disease.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31550724
 
|mesh-terms=* Anemia
* Erythrocytes
* Female
* Humans
* Male
* Middle Aged
* Renal Insufficiency, Chronic
|keywords=* Chronic kidney disease
* Erythropoietin
* Levitt’s CO breath test
* Red blood cell lifespan
* Renal anemia
|full-text-url=https://sci-hub.do/10.1159/000502525
}}
==ERCC1==
 
{{medline-entry
|title=Chronic Sildenafil Treatment Improves Vasomotor Function in a Mouse Model of Accelerated Aging.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32630010
 
 
|keywords=* aging
* cGMP
* guanylate cyclase
* hypertension
* nitric oxide
* phosphodiesterase
* sildenafil
* vascular dysfunction
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7369923
}}
{{medline-entry
|title=Local endothelial DNA repair deficiency causes aging-resembling endothelial-specific dysfunction.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32202295
 
|mesh-terms=* Age Factors
* Aging
* Animals
* Capillary Permeability
* Cellular Senescence
* Cyclin-Dependent Kinase Inhibitor p21
* DNA Damage
* DNA Repair
* DNA-Binding Proteins
* Endonucleases
* Endothelial Cells
* Endothelium, Vascular
* Mice, Inbred C57BL
* Mice, Knockout
* Nitric Oxide
* Nitric Oxide Synthase Type III
* Superoxides
* Vascular Stiffness
* Vasodilation
|keywords=* DNA damage
* aging
* endothelial dysfunction
* endothelium-dependent dilation
* nitric oxide
|full-text-url=https://sci-hub.do/10.1042/CS20190124
}}
{{medline-entry
|title=Tissue specificity of senescent cell accumulation during physiologic and accelerated aging of mice.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31981461
 
 
|keywords=* DNA repair
* ERCC1-XPF
* aging
* cellular senescence
* endogenous DNA damage
* progeria
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7059165
}}
{{medline-entry
|title=Deficiency in the DNA repair protein [[ERCC1]] triggers a link between senescence and apoptosis in human fibroblasts and mouse skin.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31737985
 
 
|keywords=* DNA damage repair
* aging
* cell death
* senescence-associated secretory phenotype
* tumor necrosis factor α
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7059167
}}
==ERF==
 
{{medline-entry
|title=Angiotensin-Converting Enzyme Gene D/I Polymorphism in Relation to Endothelial Function and Endothelial-Released Factors in Chinese Women.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/33041838
 
 
|keywords=* ACE D/I gene polymorphism
* Chinese women
* aging
* endothelial function
* endothelial-released factors
* menopause
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7526498
}}
{{medline-entry
|title=Projections of Ambient Temperature- and Air Pollution-Related Mortality Burden Under Combined Climate Change and Population Aging Scenarios: a Review.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32542573
 
 
|keywords=* Air pollution
* Climate change
* Mortality
* Population aging
* Projection
* Temperature
|full-text-url=https://sci-hub.do/10.1007/s40572-020-00281-6
}}
{{medline-entry
|title=Exome Sequencing Analysis Identifies Rare Variants in [i]ATM[/i] and [i]RPL8[/i] That Are Associated With Shorter Telomere Length.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32425970
 
 
|keywords=* ATM
* RPL8
* aging
* meta-analysis
* telomere
* whole exome sequencing
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7204400
}}
==ERG==
 
{{medline-entry
|title=Effect of age and sex on neurodevelopment and neurodegeneration in the healthy eye: Longitudinal functional and structural study in the Long-Evans rat.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32882213
 
 
|keywords=* Aging
* Electroretinography
* Neurodegeneration
* Neurodevelopment
* Optical coherence tomography
* Retina
* Sex
|full-text-url=https://sci-hub.do/10.1016/j.exer.2020.108208
}}
{{medline-entry
|title=Mice With a Combined Deficiency of Superoxide Dismutase 1 (Sod1), DJ-1 (Park7), and Parkin (Prkn) Develop Spontaneous Retinal Degeneration With Aging.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31487745
 
|mesh-terms=* Aging
* Animals
* Biomarkers
* Electroretinography
* Enzyme-Linked Immunosorbent Assay
* Immunohistochemistry
* Malondialdehyde
* Mice
* Mice, Inbred C57BL
* Mice, Knockout
* Microscopy, Electron, Transmission
* Mitochondria
* Oxidative Stress
* Protein Deglycase DJ-1
* Retina
* Retinal Degeneration
* Retinal Pigment Epithelium
* Superoxide Dismutase-1
* Tomography, Optical Coherence
* Ubiquitin-Protein Ligases
 
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6733419
}}
==ESPL1==
 
{{medline-entry
|title=Identification and genomic analysis of pedigrees with exceptional longevity identifies candidate rare variants.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32574725
 
 
|keywords=* Genomics
* Longevity
* Pedigree
* Rare variant sharing
* Utah population database
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7461696
}}
==ETS1==
 
{{medline-entry
|title=The transcription factor [[ETS1]] promotes apoptosis resistance of senescent cholangiocytes by epigenetically up-regulating the apoptosis suppressor BCL2L1.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31659122
 
|mesh-terms=* ATP Binding Cassette Transporter, Subfamily B
* Animals
* Apoptosis
* Cellular Senescence
* Hepatocytes
* Humans
* Lipopolysaccharides
* Liver
* Mice
* Proto-Oncogene Protein c-ets-1
* Transcription Factors
* bcl-X Protein
|keywords=* BCL2 like 1 (BCL2L1)
* apoptosis
* cholangiocyte
* chromatin modification
* epigenetics
* gene expression
* primary sclerosing cholangitis (PSC)
* senescence
* transcription factor
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6901313
}}
==EVL==
 
{{medline-entry
|title=Health Years in Total: A New Health Objective Function for Cost-Effectiveness Analysis.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31952678
 
|mesh-terms=* Cost-Benefit Analysis
* Health Care Costs
* Health Status
* Health Status Indicators
* Humans
* Life Expectancy
* Quality of Life
* Quality-Adjusted Life Years
* Time Factors
|keywords=* cost-effectiveness
* equal value of life
* health years in total
* quality-adjusted life-year
* thresholds
|full-text-url=https://sci-hub.do/10.1016/j.jval.2019.10.014
}}
==EZH2==
 
{{medline-entry
|title=Linking gene expression and phenotypic changes in the developmental and evolutionary origins of osteosclerosis in the ribs of bowhead whales (Balaena mysticetus).
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32729176
 
 
|keywords=* Cetacea
* aging
* bone
* hyperostosis
* osteoblasts
* whales
|full-text-url=https://sci-hub.do/10.1002/jez.b.22990
}}
{{medline-entry
|title=[[EZH2]] is involved in vulnerability to neuroinflammation and depression-like behaviors induced by chronic stress in different aged mice.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32553389
 
 
|keywords=* Aging
* CUMS
* Cytokines
* Depresion
* EZH2
* Microglia
|full-text-url=https://sci-hub.do/10.1016/j.jad.2020.03.154
}}
{{medline-entry
|title=A positive feedback loop between [[EZH2]] and NOX4 regulates nucleus pulposus cell senescence in age-related intervertebral disc degeneration.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32025238
 
 
|keywords=* Epigenetic histone modification
* Intervertebral disc degeneration
* Nucleus pulposus cell senescence
* Wnt/β-catenin signaling pathway
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6995653
}}
{{medline-entry
|title=Perinatal exposure to bisphenol A impacts in the mammary gland morphology of adult Mongolian gerbils.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31917966
 
|mesh-terms=* Actins
* Aging
* Animals
* Benzhydryl Compounds
* Cell Proliferation
* Collagen
* Enhancer of Zeste Homolog 2 Protein
* Female
* Gerbillinae
* Histones
* Mammary Glands, Animal
* Phenols
* Pregnancy
* Prenatal Exposure Delayed Effects
|keywords=* BPA
* EZH2
* Environment pollutant
* Estrogen
* Morphologic alterations
* Phospho-histone-h3
|full-text-url=https://sci-hub.do/10.1016/j.yexmp.2020.104374
}}
==F2==
 
{{medline-entry
|title=Environmental risk assessment of glufosinate-resistant soybean by pollen-mediated gene flow under field conditions in the region of the genetic origin.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/33189381
 
 
|keywords=* Glufosinate resistance
* Relative fitness
* Seed longevity
* Transgene flow
* Weed risk
|full-text-url=https://sci-hub.do/10.1016/j.scitotenv.2020.143073
}}
{{medline-entry
|title=Gestational arsenite exposure augments hepatic tumors of C3H mice by promoting senescence in F1 and [[F2]] offspring via different pathways.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/33010264
 
 
|keywords=* Arsenic
* Liver
* Multigenerational Effect
* SASP
* Senescence
* Tumor
|full-text-url=https://sci-hub.do/10.1016/j.taap.2020.115259
}}
{{medline-entry
|title=Familial Longevity is Associated with an Attenuated Thyroidal Response to Recombinant Human Thyroid Stimulating Hormone.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32303766
 
 
|keywords=* Thyroid
* longevity
* recombinant human TSH
* responsivity
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7239378
}}
{{medline-entry
|title=Conclusions from a behavioral aging study on male and female [[F2]] hybrid mice on age-related behavior, buoyancy in water-based tests, and an ethical method to assess lifespan.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31509518
 
|mesh-terms=* Adiposity
* Aging
* Animals
* Exploratory Behavior
* Female
* Male
* Memory
* Mice, Inbred BALB C
* Mice, Inbred C57BL
* Swimming
|keywords=* F2 hybrid mice
* aging
* exploratory activity
* sex comparison
* water-based behavioral tests
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6756906
}}
{{medline-entry
|title=In utero exposure to acetaminophen and ibuprofen leads to intergenerational accelerated reproductive aging in female mice.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31428698
 
|mesh-terms=* Acetaminophen
* Aging
* Animals
* Animals, Newborn
* Cell Proliferation
* Female
* Fertility
* Forkhead Box Protein O3
* Germ Cells
* Ibuprofen
* Luteolysis
* Mice
* Ovary
* Pregnancy
* Prenatal Exposure Delayed Effects
* Proto-Oncogene Proteins c-akt
* Reproduction
* Signal Transduction
|keywords=* Infertility
* Oogenesis
* Risk factors
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6692356
}}
==F3==
 
{{medline-entry
|title=A Comprehensive Analysis of Age and Gender Effects in European Portuguese Oral Vowels.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/33293174
 
 
|keywords=* Acoustic
* Aging voice
* European Portuguese
* Oral vowel
|full-text-url=https://sci-hub.do/10.1016/j.jvoice.2020.10.021
}}
{{medline-entry
|title=Prenatal exposure to an environmentally relevant phthalate mixture accelerates biomarkers of reproductive aging in a multiple and transgenerational manner in female mice.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/33129917
 
 
|keywords=* cyclicity
* hormone
* mixture
* ovary
* phthalates
* reproductive aging
* transgenerational
|full-text-url=https://sci-hub.do/10.1016/j.reprotox.2020.10.009
}}
{{medline-entry
|title=Combining Frontal Transcranial Direct Current Stimulation With Walking Rehabilitation to Enhance Mobility and Executive Function: A Pilot Clinical Trial.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32808403
 
 
|keywords=* Aging
* cognition
* rehabilitation
* transcranial direct current stimulation
* walking
|full-text-url=https://sci-hub.do/10.1111/ner.13250
}}
{{medline-entry
|title=Multigenerational exposure to TiO  nanoparticles in soil stimulates stress resistance and longevity of survived C. elegans via activating insulin/IGF-like signaling.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32203849
 
|mesh-terms=* Animals
* Caenorhabditis elegans
* Caenorhabditis elegans Proteins
* Insulin
* Longevity
* Nanoparticles
* Oxidative Stress
* Soil
* Titanium
|keywords=* Insulin/IGF-like signaling
* Longevity
* Multigenerational toxicity
* Nanomaterial
* Soil nematode
|full-text-url=https://sci-hub.do/10.1016/j.envpol.2020.114376
}}
{{medline-entry
|title=Co-expression network analysis identified hub genes critical to triglyceride and free fatty acid metabolism as key regulators of age-related vascular dysfunction in mice.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31514170
 
|mesh-terms=* Aging
* Animals
* Fatty Acids, Nonesterified
* Gene Expression Profiling
* Gene Expression Regulation
* Gene Regulatory Networks
* Lipid Metabolism
* Mice
* Microarray Analysis
* Signal Transduction
* Triglycerides
* Vascular Diseases
|keywords=* aging
* co-expression network
* hub gene
* module
* mouse
* vascular dysfunction
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6781998
}}
==F5==
 
{{medline-entry
|title=Methylation signatures in peripheral blood are associated with marked age acceleration and disease progression in patients with primary sclerosing cholangitis.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32039401
 
 
|keywords=* ALP, alkaline phosphatase
* ALT, alanine aminotransferase
* Aging
* BMI, body mass index
* DNAm, DNA methylation
* ELF, enhanced liver fibrosis
* FDR, false discovery rate
* GGT, gamma-glutamyltransferase
* IBD, inflammatory bowel disease
* IL, interleukin
* LOXL2, lysyl oxidase-like-2
* NASH, non-alcoholic steatohepatitis
* PSC, primary sclerosing cholangitis
* SMA, smooth muscle actin
* UDCA, ursodeoxycholic acid
* biomarker
* inflammatory bowel disease
* primary sclerosing cholangitis
* prognosis
* ursodeoxycholic acid
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7005566
}}
{{medline-entry
|title=Fermentation of Blackberry with [i]L. plantarum[/i] JBMI [[F5]] Enhance the Protection Effect on UVB-Mediated Photoaging in Human Foreskin Fibroblast and Hairless Mice through Regulation of MAPK/NF-κB Signaling.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31614689
 
|mesh-terms=* Animals
* Cell Line
* Cell Survival
* Female
* Fermentation
* Fibroblasts
* Foreskin
* Fruit
* Lactobacillus plantarum
* Male
* Mice
* Mice, Hairless
* Plant Extracts
* Rubus
* Skin Aging
* Ultraviolet Rays
|keywords=* Lactobacillus plantarum
* MMPs
* fermented blackberry
* photoaging
* skin aging
* type I procollagen
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6835613
}}
==F7==
 
{{medline-entry
|title=The Pattern of Mu Rhythm Modulation During Emotional Destination Memory: Comparison Between Mild Cognitive Impairment Patients and Healthy Controls.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31524160
 
|mesh-terms=* Aged
* Aging
* Cognitive Dysfunction
* Electroencephalography
* Emotions
* Female
* Frontal Lobe
* Humans
* Male
* Memory
* Neurophysiological Monitoring
* Neuropsychological Tests
* Task Performance and Analysis
* Temporal Lobe
|keywords=* Emotional destination memory
* Mu suppression
* fronto-temporal
* mild cognitive impairment
* mirror neurons
|full-text-url=https://sci-hub.do/10.3233/JAD-190311
}}
==FAAH==
 
{{medline-entry
|title=Endocannabinoid genetic variation enhances vulnerability to THC reward in adolescent female mice.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32095523
 
|mesh-terms=* Aging
* Amidohydrolases
* Animals
* Axons
* Choice Behavior
* Dronabinol
* Endocannabinoids
* Female
* Genetic Variation
* Male
* Mice, Inbred C57BL
* Nerve Net
* Nucleus Accumbens
* Polymorphism, Single Nucleotide
* Receptor, Cannabinoid, CB1
* Reward
* Tyrosine 3-Monooxygenase
* Ventral Tegmental Area
 
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7015690
}}
==FABP3==
 
{{medline-entry
|title=[[FABP3]]-mediated membrane lipid saturation alters fluidity and induces ER stress in skeletal muscle with aging.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/33168829
 
|mesh-terms=* Aging
* Animals
* Cell Line
* Endoplasmic Reticulum Stress
* Eukaryotic Initiation Factor-2
* Fatty Acid Binding Protein 3
* Female
* Gene Knockdown Techniques
* Lipidomics
* Membrane Fluidity
* Membrane Lipids
* Mice, Inbred C57BL
* Mice, Knockout
* Muscle, Skeletal
* Myoblasts
* Phospholipids
* Protein-Serine-Threonine Kinases
* Sarcopenia
* Up-Regulation
 
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7653047
}}
{{medline-entry
|title=Autophagy receptor OPTN (optineurin) regulates mesenchymal stem cell fate and bone-fat balance during aging by clearing [[FABP3]].
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/33143524
 
 
|keywords=* Adipogenesis
* autophagy
* bone metabolism
* fabp3
* mesenchymal stem cell
* optineurin
* osteogenesis
* osteoporosis
* senescence
|full-text-url=https://sci-hub.do/10.1080/15548627.2020.1839286
}}
{{medline-entry
|title=Myokines as biomarkers of frailty and cardiovascular disease risk in females.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32017952
 
 
|keywords=* Aging
* Biomarkers
* Cardiovascular disease
* Females
* Frailty
* Myokines
|full-text-url=https://sci-hub.do/10.1016/j.exger.2020.110859
}}
==FADS1==
 
{{medline-entry
|title=Aging and [[FADS1]] polymorphisms decrease the biosynthetic capacity of long-chain PUFAs: A human trial using [U- C]linoleic acid.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31492428
 
|mesh-terms=* Adult
* Age Factors
* Aged
* Aging
* Alleles
* Arachidonic Acid
* Area Under Curve
* Fatty Acid Desaturases
* Fatty Acids, Unsaturated
* Female
* Healthy Volunteers
* Humans
* Linoleic Acid
* Male
* Polymorphism, Single Nucleotide
|keywords=* Aging
* Arachidonic acid
* Fatty acid conversion
* Linoleic acid
* Lipid metabolism
* Long-chain polyunsaturated fatty acid
|full-text-url=https://sci-hub.do/10.1016/j.plefa.2019.07.003
}}
==FANCD2==
 
{{medline-entry
|title=TFG-maintaining stability of overlooked [[FANCD2]] confers early DNA-damage response.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/33099537
 
 
|keywords=* DNA damage response
* FANCD2
* TFG
* aging and cancer
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7655164
}}
==FAP==
 
{{medline-entry
|title=Rapamycin Extends Life Span in Apc  Colon Cancer [[FAP]] Model.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/33132009
 
 
|keywords=* Aging
* Crypt stem cells
* eEF2K
* mTORC1
* rpS6
|full-text-url=https://sci-hub.do/10.1016/j.clcc.2020.08.006
}}
{{medline-entry
|title=Exercise enhances skeletal muscle regeneration by promoting senescence in fibro-adipogenic progenitors.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32060352
 
|mesh-terms=* Aging
* Animals
* Apoptosis
* Exercise Therapy
* Female
* Humans
* Mesenchymal Stem Cells
* Mice
* Mice, Inbred BALB C
* Mice, Inbred C57BL
* Muscle, Skeletal
* Muscular Diseases
* Regeneration
 
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7021787
}}
{{medline-entry
|title=Control of Muscle Fibro-Adipogenic Progenitors by Myogenic Lineage is Altered in Aging and Duchenne Muscular Dystrophy.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31865646
 
|mesh-terms=* Adipogenesis
* Adolescent
* Adult
* Adult Stem Cells
* Aged
* Aging
* Cells, Cultured
* Child
* Child, Preschool
* Female
* Humans
* Infant
* Male
* Middle Aged
* Muscle Development
* Muscular Dystrophy, Duchenne
* Myoblasts
* Young Adult
|keywords=Adipocytes; Myofibroblasts; Muscle progenitors; Myopathies
|full-text-url=https://sci-hub.do/10.33594/000000196
}}
==FAS==
 
{{medline-entry
|title=Five-year change in maximum tongue pressure and physical function in community-dwelling elderly adults.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32952883
 
 
|keywords=* Aging
* Biological age
* Elderly
* Physical function
* Tongue pressure
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7486543
}}
{{medline-entry
|title=Inhibition of USP7 activity selectively eliminates senescent cells in part via restoration of p53 activity.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32064756
 
 
|keywords=* MDM2
* Senescence
* USP7
* apoptosis
* p53
* senolytics
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7059172
}}
==FES==
 
{{medline-entry
|title=An outpatient Tai Chi program: Effects on veterans' functional outcomes.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/33241873
 
 
|keywords=* Tai Chi
* balance
* exercise
* gait
* geriatrics
|full-text-url=https://sci-hub.do/10.1111/nuf.12532
}}
{{medline-entry
|title=Gait Function in Adults Aged 50 Years and Older With Spina Bifida.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/33166524
 
 
|keywords=* Adult
* Aging
* Gait analysis
* Myelomeningocele
* Rehabilitation
|full-text-url=https://sci-hub.do/10.1016/j.apmr.2020.10.118
}}
{{medline-entry
|title=A Single Question as a Screening Tool to Assess Fear of Falling in Young-Old Community-Dwelling Persons.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32165062
 
 
|keywords=* FES-I
* elderly
* fear of falling
* healthy aging
* older adults
|full-text-url=https://sci-hub.do/10.1016/j.jamda.2020.01.101
}}
{{medline-entry
|title=Fall-related efficacy is a useful and independent index to detect fall risk in Japanese community-dwelling older people: a 1-year longitudinal study.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31664911
 
|mesh-terms=* Accidental Falls
* Activities of Daily Living
* Aged
* Aging
* Female
* Geriatric Assessment
* Humans
* Independent Living
* Japan
* Longitudinal Studies
* Male
* Physical Functional Performance
* Postural Balance
* Risk Factors
* Walking Speed
|keywords=* Accidental falls
* Aged
* Fall-related efficacy
* Japanese
* Physical performance
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6820944
}}
{{medline-entry
|title=Investigating Changes in Real-time Conscious Postural Processing by Older Adults during Different Stance Positions Using Electroencephalography Coherence.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31514583
 
|mesh-terms=* Accidental Falls
* Aged
* Aging
* Brain
* Electroencephalography
* Fear
* Female
* Humans
* Male
* Movement
* Postural Balance
* Posture
 
|full-text-url=https://sci-hub.do/10.1080/0361073X.2019.1664450
}}
==FEV==
 
{{medline-entry
|title=Prediction of Lung Function in Adolescence Using Epigenetic Aging: A Machine Learning Approach.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/33182250
 
 
|keywords=* epigenetic aging
* feature selection
* hyperparameter tuning
* lung function
* machine learning
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7712054
}}
{{medline-entry
|title=Effect of Age on the Efficacy and Safety of Once-Daily Single-Inhaler Triple Therapy Fluticasone Furoate/Umeclidinium/Vilanterol in Patients With Chronic Obstructive Pulmonary Disease: A Post Hoc Analysis of the IMPACT Trial.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/33031829
 
 
|keywords=* COPD
* aging
* exacerbations
* safety
* single-inhaler triple therapy
|full-text-url=https://sci-hub.do/10.1016/j.chest.2020.09.253
}}
{{medline-entry
|title=A comprehensive analysis of factors related to lung function in older adults: Cross-sectional findings from the Canadian Longitudinal Study on Aging.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/33010732
 
 
|keywords=* Aging
* Determinants
* Lung function
* Sex
* Spirometry
|full-text-url=https://sci-hub.do/10.1016/j.rmed.2020.106157
}}
{{medline-entry
|title=Risk factors associated with the detection of pulmonary emphysema in older asymptomatic respiratory subjects.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32517728
 
 
|keywords=* Aging
* COPD
* Klotho
* Pulmonary emphysema
* Risk factors
* Telomere length
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7285611
}}
{{medline-entry
|title=Tiotropium Respimat Efficacy and Safety in Asthma: Relationship to Age.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32320797
 
 
|keywords=* Aging
* Asthma
* Long-acting muscarinic antagonist
* Long-acting β(2)-agonists
* Pharmacotherapy
|full-text-url=https://sci-hub.do/10.1016/j.jaip.2020.04.013
}}
{{medline-entry
|title=Current Bronchodilator Responsiveness Criteria Underestimate Asthma in Older Adults.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32071132
 
 
|keywords=* aging
* albuterol
* asthma
* bronchodilator effect
* lung diseases
* older adult
* spirometry
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7538007
}}
{{medline-entry
|title=Physical performances show conflicting associations in aged manual workers.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32042126
 
|mesh-terms=* Aged
* Aging
* Body Composition
* Body Mass Index
* Cardiorespiratory Fitness
* Cross-Sectional Studies
* Hand Strength
* Humans
* Lung
* Male
* Middle Aged
* Physical Functional Performance
 
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7010773
}}
{{medline-entry
|title=[[FEV]]  as a Standalone Spirometric Predictor and the Attributable Fraction for Death in Older Persons.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31662447
 
 
|keywords=* aging
* average attributable fraction
* death
* relative risk
* spirometry
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7055488
}}
{{medline-entry
|title=An Individualized Prediction Model for Long-term Lung Function Trajectory and Risk of COPD in the General Population.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31542453
 
|mesh-terms=* Adult
* Age Factors
* Aging
* Alcohol Drinking
* Algorithms
* Alkaline Phosphatase
* Body Height
* Bronchodilator Agents
* Cigarette Smoking
* Cohort Studies
* Cough
* Dyspnea
* Electrocardiography
* Female
* Forced Expiratory Volume
* Hematocrit
* Humans
* Leukocyte Count
* Longitudinal Studies
* Lung
* Machine Learning
* Male
* Middle Aged
* Pulmonary Disease, Chronic Obstructive
* Risk Assessment
* Serum Albumin
* Serum Globulins
* Sex Factors
* Spirometry
* Triglycerides
* Vital Capacity
|keywords=* COPD
* FEV(1)
* FEV(1)/FVC
* airflow limitation
* lung function
* predictive modeling
|full-text-url=https://sci-hub.do/10.1016/j.chest.2019.09.003
}}
{{medline-entry
|title=Telomere length and lung function in a population-based cohort of children and mid-life adults.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31456360
 
|mesh-terms=* Aged
* Asthma
* Body Mass Index
* Child
* Cohort Studies
* Cross-Sectional Studies
* Exercise
* Female
* Forced Expiratory Volume
* Humans
* Lung
* Male
* Respiratory Function Tests
* Risk Factors
* Smoking
* Spirometry
* Telomere
* Vital Capacity
|keywords=* aging
* cell senescence
* life course
* national cohort
* spirometry
|full-text-url=https://sci-hub.do/10.1002/ppul.24489
}}
==FGA==
 
{{medline-entry
|title=Goal Pursuit, Goal Adjustment, and Pain in Middle-Aged Adults Aging With Physical Disability.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31718416
 
|mesh-terms=* Adaptation, Psychological
* Aged
* Aging
* Depression
* Disabled Persons
* Female
* Goals
* Humans
* Male
* Middle Aged
* Multiple Sclerosis
* Muscular Dystrophies
* Pain
* Postpoliomyelitis Syndrome
* Spinal Cord Injuries
|keywords=* aging
* disability
* goal management
* pain
* psychological adaptation
|full-text-url=https://sci-hub.do/10.1177/0898264319827142
}}
{{medline-entry
|title=Tenacious Goal Pursuit, Flexible Goal Adjustment, and Life Satisfaction Among Chinese Older Adult Couples.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31547780
 
 
|keywords=* flexible goal adjustment
* life satisfaction
* older couples
* self-perceptions of aging
* tenacious goal pursuit
|full-text-url=https://sci-hub.do/10.1177/0164027519876125
}}
==FGF19==
 
{{medline-entry
|title=Bile acid receptor agonists in primary biliary cholangitis: Regulation of the cholangiocyte secretome and downstream T cell differentiation.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32123836
 
 
|keywords=* FGF19
* FXR
* TGR5
* autoimmunity
* senescence
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6996327
}}
==FGF2==
 
{{medline-entry
|title=The influence of fibroblast growth factor 2 on the senescence of human adipose-derived mesenchymal stem cells during long-term culture.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31840944
 
 
|keywords=* cell proliferation
* cellular senescence
* fibroblast growth factor 2
* long-term culture
* mesenchymal stem cell
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7103622
}}
==FGF21==
 
{{medline-entry
|title=Differential effects of sulfur amino acid-restricted and low-calorie diets on gut microbiome profile and bile acid composition in male C57BL6/J mice.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/33106871
 
 
|keywords=* Clostridales
* firmicutes
* lifespan
* methionine restriction
* sulfur metabolism
|full-text-url=https://sci-hub.do/10.1093/gerona/glaa270
}}
{{medline-entry
|title=Relationship between physical activity and circulating fibroblast growth factor 21 in middle-aged and older adults.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32911033
 
 
|keywords=* Accelerometer
* Activity intensity
* Aging
* FGF21
* Physical activity
|full-text-url=https://sci-hub.do/10.1016/j.exger.2020.111081
}}
{{medline-entry
|title=Exercise and dietary intervention ameliorate high-fat diet-induced NAFLD and liver aging by inducing lipophagy.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32863214
 
 
|keywords=* Aging
* Exercise
* FGF21
* Lipophagy
* Nonalcoholic fatty liver disease (NAFLD)
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7365984
}}
{{medline-entry
|title=Mitochondria, immunosenescence and inflammaging: a role for mitokines?
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32757036
 
 
|keywords=* Human ageing
* Immunosenescence
* Inflammaging
* Mitochondrial metabolism
* Mitokines
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7666292
}}
{{medline-entry
|title=Age-at-onset-dependent effects of sulfur amino acid restriction on markers of growth and stress in male F344 rats.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32573078
 
 
|keywords=* ER stress
* cysteine
* glutathione
* hormesis
* lifespan
* methionine
* trade-offs
* translational
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7426777
}}
{{medline-entry
|title=Fibroblast growth factor 21 prolongs lifespan and improves stress tolerance in the silkworm, [i]Bombyx mori[/i].
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32309367
 
 
|keywords=* Bombyx mori
* fibroblast growth factor 21 (FGF21)
* lifespan
* oxidation resistance
* stress tolerance
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7154471
}}
{{medline-entry
|title=Neurogenesis and prolongevity signaling in young germ-free mice transplanted with the gut microbiota of old mice.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31723038
 
|mesh-terms=* Animals
* Butyrates
* Fecal Microbiota Transplantation
* Fibroblast Growth Factors
* Gastrointestinal Microbiome
* Germ-Free Life
* Hippocampus
* Intestines
* Liver
* Longevity
* Male
* Metabolome
* Mice, Inbred C57BL
* Microtubule-Associated Proteins
* Neurogenesis
* Neurons
* Neuropeptides
* Phenotype
* Proton Magnetic Resonance Spectroscopy
 
|full-text-url=https://sci-hub.do/10.1126/scitranslmed.aau4760
}}
{{medline-entry
|title=Fibroblast Growth Factor 21 Mediates the Associations between Exercise, Aging, and Glucose Regulation.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31490857
 
|mesh-terms=* Adiponectin
* Adult
* Aging
* Blood Glucose
* Blood Pressure
* Body Mass Index
* Diabetes Mellitus, Type 2
* Exercise
* Female
* Fibroblast Growth Factors
* Glucose Tolerance Test
* Humans
* Insulin
* Lipids
* Male
* Middle Aged
* Risk Factors
 
|full-text-url=https://sci-hub.do/10.1249/MSS.0000000000002150
}}
{{medline-entry
|title=Effects of Moderate Chronic Food Restriction on the Development of Postprandial Dyslipidemia with Ageing.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31405194
 
|mesh-terms=* Adiposity
* Aging
* Animals
* Basic Helix-Loop-Helix Leucine Zipper Transcription Factors
* Blood Glucose
* Diet, Fat-Restricted
* Dietary Fats
* Disease Models, Animal
* Dyslipidemias
* Glucagon
* Insulin
* Lipids
* Liver
* Metabolic Syndrome
* Postprandial Period
* Rats
* Rats, Wistar
* Triglycerides
|keywords=* ChREBP
* adipose tissue
* ageing
* oral lipid loading test
* postprandial hypertrigliceridemia
* postprandial thermogenesis
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6723802
}}
==FGF23==
 
{{medline-entry
|title=Phosphate as a Pathogen of Arteriosclerosis and Aging.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/33028781
 
 
|keywords=* Aging
* Calciprotein particles (CPPs)
* Fibroblast growth factor-23 (FGF23)
* Inflammation
* Klotho
* Phosphate
* Vascular calcification
|full-text-url=https://sci-hub.do/10.5551/jat.RV17045
}}
{{medline-entry
|title=Plasma Soluble αKlotho, Serum Fibroblast Growth Factor 23, and Mobility Disability in Community-Dwelling Older Adults.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32405607
 
 
|keywords=* aging
* chronic kidney disease
* fibroblast growth factor 23
* mobility disability
* αKlotho
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7209777
}}
{{medline-entry
|title=Protective effect of Polygonatum sibiricum Polysaccharide on D-galactose-induced aging rats model.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32042011
 
|mesh-terms=* Aging
* Animals
* Calcium
* Dietary Carbohydrates
* Fibroblast Growth Factors
* Galactose
* Glucuronidase
* Male
* Oxidative Stress
* Phosphorus
* Phytochemicals
* Polygonatum
* Polysaccharides
* Protective Agents
* Rats
* Rats, Sprague-Dawley
 
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7010663
}}
{{medline-entry
|title=[[FGF23]] expression is stimulated in transgenic α-Klotho longevity mouse model.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31801907
 
|mesh-terms=* Aldosterone
* Animals
* Bone and Bones
* Cardiovascular Diseases
* Disease Models, Animal
* Female
* Fibroblast Growth Factors
* Gene Knockout Techniques
* Glucuronidase
* Kidney
* Longevity
* Male
* Mice
* Mice, Inbred C57BL
* Mice, Transgenic
* Osteoblasts
* Protein Isoforms
* Transcriptome
|keywords=* Bone Biology
* Cardiovascular disease
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6962016
}}
{{medline-entry
|title=Fibroblast growth factor 23 and symmetric dimethylarginine concentrations in geriatric cats.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31568615
 
|mesh-terms=* Aging
* Animals
* Arginine
* Biomarkers
* Cats
* Cross-Sectional Studies
* Female
* Fibroblast Growth Factors
* Male
* Reference Values
* Retrospective Moral Judgment
|keywords=* azotemia
* feline
* phosphate
* renal
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6872607
}}
==FGFR1==
 
{{medline-entry
|title=Alignment of Alzheimer's disease amyloid β-peptide and klotho.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32999998
 
 
|keywords=* Alzheimer’s disease
* HSV-1
* aging
* alignment
* klotho
* neurodegeneration
* neuroinflammation
* protein
* ubiquitin
* β-amyloid
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7521834
}}
{{medline-entry
|title=Satellite cell-specific ablation of Cdon impairs integrin activation, FGF signalling, and muscle regeneration.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32103583
 
 
|keywords=* Cdon
* Cellular senescence
* FGFR
* Growth factor signalling
* Muscle regeneration
* Satellite cell
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7432598
}}
==FGFR4==
 
{{medline-entry
|title=[[FGFR4]] Inhibitor BLU9931 Attenuates Pancreatic Cancer Cell Proliferation and Invasion While Inducing Senescence: Evidence for Senolytic Therapy Potential in Pancreatic Cancer.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/33066597
 
 
|keywords=* FGFR4
* FGFR4 inhibitor
* growth
* invasion
* pancreatic cancer
* senescence
* senolytic therapy
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7602396
}}
==FGR==
 
{{medline-entry
|title=Aurora kinase mRNA expression is reduced with increasing gestational age and in severe early onset fetal growth restriction.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32452402
 
 
|keywords=* Aurora kinase
* Cellular senescence
* FGR
* Preeclampsia
|full-text-url=https://sci-hub.do/10.1016/j.placenta.2020.04.012
}}
==FH==
 
{{medline-entry
|title=Genetic Factors of Alzheimer's Disease Modulate How Diet is Associated with Long-Term Cognitive Trajectories: A UK Biobank Study.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/33252089
 
 
|keywords=* APOE4
* Aging
* Mediterranean diet
* cognitive decline
* functional food
* lamb
* nutrition policy
* preventive medicine
* red wine
* salt
|full-text-url=https://sci-hub.do/10.3233/JAD-201058
}}
{{medline-entry
|title=Volumetric alterations in the hippocampal subfields of subjects at increased risk of dementia.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32311609
 
|mesh-terms=* Adult
* Aging
* Alzheimer Disease
* Apolipoproteins E
* Atrophy
* Dementia
* Diffusion Magnetic Resonance Imaging
* Educational Status
* Female
* Genotype
* Hippocampus
* Humans
* Male
* Middle Aged
* Organ Size
* Risk
|keywords=* Alzheimer's disease
* Dementia
* Hippocampal subfields
* Hippocampus
* Preclinical dementia
|full-text-url=https://sci-hub.do/10.1016/j.neurobiolaging.2020.03.006
}}
{{medline-entry
|title=Macroscopic hematuria as a risk factor for hypertension in ageing people with hemophilia and a family history of hypertension.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32118768
 
|mesh-terms=* Adult
* Aged
* Aged, 80 and over
* Aging
* Cross-Sectional Studies
* Female
* Hematuria
* Hemophilia A
* Humans
* Hypertension
* Israel
* Logistic Models
* Male
* Middle Aged
* Risk Factors
 
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7478422
}}
{{medline-entry
|title=LDL Receptor Deficiency Does not Alter Brain Amyloid-β Levels but Causes an Exacerbation of Apoptosis.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31815695
 
|mesh-terms=* Aging
* Amyloid beta-Protein Precursor
* Animals
* Apoptosis
* Brain Chemistry
* Caspase 3
* Cholesterol
* Gene Expression
* Hippocampus
* Male
* Maze Learning
* Mice
* Mice, Inbred C57BL
* Mice, Knockout
* Prefrontal Cortex
* Receptors, LDL
|keywords=* Familial hypercholesterolemia
* LDLr-/- mice
* amyloid-β
* apoptosis
* memory impairment
|full-text-url=https://sci-hub.do/10.3233/JAD-190742
}}
==FNDC5==
 
{{medline-entry
|title=Irisin Correlates Positively With BMD in a Cohort of Older Adult Patients and Downregulates the Senescent Marker p21 in Osteoblasts.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/33053231
 
 
|keywords=* BONE-MUSCLE INTERACTIONS
* IRISIN
* OSTEOPOROSIS
* SARCOPENIA
* SENESCENCE
|full-text-url=https://sci-hub.do/10.1002/jbmr.4192
}}
{{medline-entry
|title=[Investigation of signal molecules in saliva: prospects of application for diagnostics of myocardial infarction and the aging rate of different age people.]
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31512422
 
|mesh-terms=* Aged
* Aging
* Biomarkers
* Cytokines
* Humans
* Middle Aged
* Myocardial Infarction
* Saliva
* Tumor Necrosis Factor-alpha
|keywords=* aging
* diagnosis
* myocardial infarction
* saliva
* signaling molecules
 
}}
==FOS==
 
{{medline-entry
|title=Muscle atrophy-related myotube-derived exosomal microRNA in neuronal dysfunction: Targeting both coding and long noncoding RNAs.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32233025
 
 
|keywords=* HIF-1α-AS2
* aging
* lncRNAs
* miR-29b-3p
* muscle atrophy
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7253071
}}
==FOSL2==
 
{{medline-entry
|title=LncRNA GUARDIN suppresses cellular senescence through a LRP130-PGC1α-FOXO4-p21-dependent signaling axis.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32149459
 
 
|keywords=*
GUARDIN
 
* LRP130-PGC1α
* cellular senescence
* lncRNAs
* p21
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7132339
}}
==FOXA1==
 
{{medline-entry
|title=Analyses of an epigenetic switch involved in the activation of pioneer factor [[FOXA1]] leading to the prognostic value of estrogen receptor and [[FOXA1]] co-expression in breast cancer.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31562808
 
|mesh-terms=* Breast Neoplasms
* Down-Regulation
* Epigenesis, Genetic
* Female
* Gene Expression Regulation, Neoplastic
* Hepatocyte Nuclear Factor 3-alpha
* Humans
* Middle Aged
* Prognosis
* RNA, Messenger
* Receptor, ErbB-2
* Receptors, Estrogen
* Receptors, Progesterone
* Transcriptome
* Up-Regulation
|keywords=* FOXA1
* age-related diseases
* aging
* breast cancer
* hormone receptor
* methylation
* prognosis
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6782010
}}
==FOXM1==
 
{{medline-entry
|title=Sirtuin 6 deficiency induces endothelial cell senescence via downregulation of forkhead box M1 expression.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/33171439
 
 
|keywords=* FOXM1
* SIRT6
* cell cycle
* endothelial cell
* senescence
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7695388
}}
==FOXN1==
 
{{medline-entry
|title=Thymic rejuvenation via [[FOXN1]]-reprogrammed embryonic fibroblasts (FREFs) to counteract age-related inflammation.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32790650
 
 
|keywords=* Aging
* Immunology
* Immunotherapy
* T cell development
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7526556
}}
==FOXO1==
 
{{medline-entry
|title=l-Theanine attenuates liver aging by inhibiting advanced glycation end products in d-galactose-induced rats and reversing an imbalance of oxidative stress and inflammation.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31899338
 
 
|keywords=* AGEs
* Inflammatory response
* Liver aging
* Oxidative stress
* l-Theanine
|full-text-url=https://sci-hub.do/10.1016/j.exger.2019.110823
}}
==FOXO3==
 
{{medline-entry
|title=The DNA methylation of [[FOXO3]] and TP53 as a blood biomarker of late-onset asthma.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/33298101
 
 
|keywords=* Aging
* DNA methylation
* FOXO3
* Late-onset asthma
* TP53
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7726856
}}
{{medline-entry
|title=[[FOXO3]] targets are reprogrammed as Huntington's disease neural cells and striatal neurons face senescence with p16  increase.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/33156570
 
 
|keywords=* neurodegenerative disease
* neuronal differentiation
* neuronal senescence
* response mechanisms
* temporal dynamics
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7681055
}}
{{medline-entry
|title=Astaxanthin as a Putative Geroprotector: Molecular Basis and Focus on Brain Aging.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32635607
 
 
|keywords=* FOXO3
* NRF2
* SIRT1
* astaxanthin
* geroprotector
* longevity
* neuroprotection
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7401246
}}
{{medline-entry
|title=Inflamma-miR-21 Negatively Regulates Myogenesis during Ageing.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32340146
 
 
|keywords=* IL6
* IL6R
* aging
* cachexia
* miR-21
* microRNA
* muscle
* regeneration
* sarcopenia
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7222422
}}
{{medline-entry
|title=Variable DNA methylation of aging-related genes is associated with male COPD.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31684967
 
|mesh-terms=* Adolescent
* Adult
* Age Factors
* Aged
* Aged, 80 and over
* Aging
* Case-Control Studies
* CpG Islands
* DNA Methylation
* Databases, Genetic
* Female
* Forced Expiratory Volume
* Forkhead Transcription Factors
* Genetic Predisposition to Disease
* Humans
* Lung
* Male
* Middle Aged
* Pulmonary Disease, Chronic Obstructive
* Risk Assessment
* Risk Factors
* Severity of Illness Index
* Sex Factors
* Transcriptome
* Vital Capacity
* Young Adult
|keywords=* Aging
* Aging-related genes
* COPD
* DNA methylation
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6829949
}}
{{medline-entry
|title=A conserved role of the insulin-like signaling pathway in diet-dependent uric acid pathologies in Drosophila melanogaster.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31415568
 
|mesh-terms=* Animals
* Animals, Genetically Modified
* Cohort Studies
* Disease Models, Animal
* Drosophila melanogaster
* Feeding Behavior
* Female
* Gene Knockdown Techniques
* Gout
* Humans
* Insulin
* Kidney Calculi
* Longevity
* Male
* Metabolic Networks and Pathways
* Middle Aged
* NADPH Oxidases
* Polymorphism, Single Nucleotide
* Purines
* Signal Transduction
* Urate Oxidase
* Uric Acid
 
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6695094
}}
==FOXO4==
 
{{medline-entry
|title=[[FOXO4]]-DRI alleviates age-related testosterone secretion insufficiency by targeting senescent Leydig cells in aged mice.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31959736
 
 
|keywords=* FOXO4-DRI
* Leydig cell
* male late-onset hypogonadism
* senescence
* senolytics
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7053614
}}
==FOXP1==
 
{{medline-entry
|title=GATA6 regulates aging of human mesenchymal stem/stromal cells.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/33252174
 
 
|keywords=* aging
* cell signaling
* mesenchymal stem cells
* reprogramming
* transcription factors
|full-text-url=https://sci-hub.do/10.1002/stem.3297
}}
==FSHR==
 
{{medline-entry
|title=[[FSHR]] ablation induces depression-like behaviors.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32203083
 
 
|keywords=* FSH
* ROS
* aging
* antioxidants
* depression
* metabolism
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7468367
}}
{{medline-entry
|title=Direct actions of gonadotropins beyond the reproductive system and their role in human aging and neoplasia [Bezpośrednie działanie gonadotropin poza układem rozrodczym i ich rola w starzeniu się i nowotworzeniu u człowieka].
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31681968
 
|mesh-terms=* Aging
* Female
* Gonadotropin-Releasing Hormone
* Gonadotropins
* Humans
* Hypothalamo-Hypophyseal System
* Luteinizing Hormone
* Male
* Receptors, FSH
* Receptors, LH
|keywords=* aging
* folitropin
* lutropin
* neoplasia
|full-text-url=https://sci-hub.do/10.5603/EP.a2019.0034
}}
==FTO==
 
{{medline-entry
|title=Decreased expression of m A demethylase [[FTO]] in ovarian aging.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/33221958
 
 
|keywords=* Epigenetics
* FTO
* Ovarian aging
* Ovarian reserve
* m6A
|full-text-url=https://sci-hub.do/10.1007/s00404-020-05895-7
}}
==FYN==
 
{{medline-entry
|title=An inhibitor role of Nrf2 in the regulation of myocardial senescence and dysfunction after myocardial infarction.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32781064
 
|mesh-terms=* Animals
* Cardiomyopathies
* Cellular Senescence
* Echocardiography
* Gene Silencing
* Male
* Mice
* Mice, Inbred C57BL
* Mice, Knockout
* Myocardial Infarction
* Myocardium
* Myocytes, Cardiac
* NF-E2-Related Factor 2
* RNA, Small Interfering
* Ventricular Remodeling
|keywords=* Cellular senescence
* Myocardial infarction
* Nrf2
* Oxidative stress
|full-text-url=https://sci-hub.do/10.1016/j.lfs.2020.118199
}}
==G6PD==
 
{{medline-entry
|title=[[G6PD]] overexpression protects from oxidative stress and age-related hearing loss.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/33222382
 
 
|keywords=* ARHL
* NADPH
* TrxR
* aging
* glutathione
|full-text-url=https://sci-hub.do/10.1111/acel.13275
}}
{{medline-entry
|title=The Sickle Effect: The Silent Titan Affecting Glycated Hemoglobin Reliability.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32923278
 
 
|keywords=* diabetes
* genetics
* glycosylated hemoglobin
* hba1c
* hbas
* race
* rbc lifespan
* sickle cell trait
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7486097
}}
{{medline-entry
|title=DNA damage and synaptic and behavioural disorders in glucose-6-phosphate dehydrogenase-deficient mice.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31581069
 
|mesh-terms=* Animals
* Brain
* DNA Breaks, Double-Stranded
* DNA Breaks, Single-Stranded
* DNA Damage
* Disease Models, Animal
* Enzyme Activation
* Female
* Glucosephosphate Dehydrogenase
* Glucosephosphate Dehydrogenase Deficiency
* Male
* Mental Disorders
* Mice
* Oxidation-Reduction
* Purkinje Cells
|keywords=* 8-Oxo-2′-deoxyguanine (8-oxodG)
* Aging
* Behavioural disorders
* Comet
* DNA damage
* Electrophysiology
* Gamma-H2AX (γH2AX)
* Glucose-6-phosphate dehydrogenase (G6PD)
* Lifespan
* Neurodegeneration
* Reactive oxygen species (ROS)
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6812046
}}
==GAA==
 
{{medline-entry
|title=Mitochondrial damage and senescence phenotype of cells derived from a novel frataxin G127V point mutation mouse model of Friedreich's ataxia.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32586831
 
 
|keywords=* Frataxin
* Friedreich's ataxia
* Mitochondria
* Oxidative stress
* Point mutation
* Senescence
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7406325
}}
{{medline-entry
|title=Age-Related Changes in Serum Guanidinoacetic Acid in Women.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31647299
 
|mesh-terms=* Adolescent
* Adult
* Aged
* Aging
* Biomarkers
* Energy Metabolism
* Exercise
* Female
* Glycine
* Humans
* Independent Living
* Middle Aged
* Young Adult
 
|full-text-url=https://sci-hub.do/10.33549/physiolres.934189
}}
==GABARAP==
 
{{medline-entry
|title=Age-dependent loss of adipose Rubicon promotes metabolic disorders via excess autophagy.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32811819
 
|mesh-terms=* Adipocytes
* Adipogenesis
* Adipose Tissue
* Adiposity
* Aging
* Animals
* Apoptosis Regulatory Proteins
* Autophagy
* Fatty Liver
* Gene Knockout Techniques
* Glucose
* HEK293 Cells
* Humans
* Intracellular Signaling Peptides and Proteins
* Lipid Metabolism
* Metabolic Diseases
* Mice
* Mice, Inbred C57BL
* Mice, Knockout
* Microtubule-Associated Proteins
* Nuclear Receptor Coactivator 1
* Nuclear Receptor Coactivator 2
* PPAR gamma
 
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7434891
}}
==GAL==
 
{{medline-entry
|title=Overexpression of Pitx1 attenuates the senescence of chondrocytes from osteoarthritis degeneration cartilage-A self-controlled model for studying the etiology and treatment of osteoarthritis.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31783149
 
 
|keywords=* Osteoarthritis
* Pitx1
* Senescence
* Sirt1
|full-text-url=https://sci-hub.do/10.1016/j.bone.2019.115177
}}
{{medline-entry
|title=β-Caryophyllene Reduces DNA Oxidation and the Overexpression of Glial Fibrillary Acidic Protein in the Prefrontal Cortex and Hippocampus of d-Galactose-Induced Aged BALB/c Mice.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31663807
 
|mesh-terms=* Aging
* Animals
* Antioxidants
* DNA Damage
* Disease Models, Animal
* Galactose
* Glial Fibrillary Acidic Protein
* Hippocampus
* Male
* Mice
* Mice, Inbred BALB C
* Neuroprotection
* Oxidative Stress
* Polycyclic Sesquiterpenes
* Prefrontal Cortex
|keywords=* CB2 receptor agonist
* biological aging
* cognitive flexibility
* phytocannabinoid
* β-caryophyllene
|full-text-url=https://sci-hub.do/10.1089/jmf.2019.0111
}}
==GAP43==
 
{{medline-entry
|title=HDAC inhibition leads to age-dependent opposite regenerative effect upon PTEN deletion in rubrospinal axons after SCI.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32171589
 
|mesh-terms=* Aging
* Animals
* Axons
* GAP-43 Protein
* Gene Deletion
* Gene Expression
* Histone Deacetylase Inhibitors
* Histone Deacetylases
* Hydroxamic Acids
* Mice, Transgenic
* Motor Activity
* Nerve Regeneration
* PTEN Phosphohydrolase
* Recovery of Function
* Spinal Cord
* Spinal Cord Injuries
|keywords=* Aging
* Epigenetics
* Histone deacetylase
* Pten
* Regeneration
* Spinal cord injury
|full-text-url=https://sci-hub.do/10.1016/j.neurobiolaging.2020.02.006
}}
==GATA4==
 
{{medline-entry
|title=Epigenetics and Vascular Senescence-Potential New Therapeutic Targets?
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/33101015
 
 
|keywords=* calcification
* cell senescence
* epigenetics
* inflammation
* oxidation stress
* vascular aging
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7556287
}}
{{medline-entry
|title=Prolonged treatment with Y-27632 promotes the senescence of primary human dermal fibroblasts by increasing the expression of IGFBP-5 and transforming them into a CAF-like phenotype.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32843583
 
 
|keywords=* IGFBP-5
* Rho kinase inhibitor
* Y-27632
* dermal fibroblast
* senescence
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7485707
}}
==GBA==
 
{{medline-entry
|title=Reduced sphingolipid hydrolase activities, substrate accumulation and ganglioside decline in Parkinson's disease.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31703585
 
|mesh-terms=* Aged
* Aging
* Female
* Glucosylceramidase
* Humans
* Hydrolases
* Lysosomes
* Male
* Mutation
* Parkinson Disease
* Risk Factors
* Substantia Nigra
* alpha-Synuclein
|keywords=* Ageing
* Ganglioside
* Glucocerebrosidase
* Glycosphingolipid
* Lysosome
* Neurodegeneration
* Parkinson’s disease
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6842240
}}
==GC==
 
{{medline-entry
|title=Body Size and Cuticular Hydrocarbons as Larval Age Indicators in the Forensic Blow Fly, Chrysomya albiceps (Diptera: Calliphoridae).
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/33274739
 
 
|keywords=*
          Chrysomya albiceps
       
* body size
* cuticular hydrocarbon
* forensic
* larval longevity
|full-text-url=https://sci-hub.do/10.1093/jme/tjaa256
}}
{{medline-entry
|title=Composition of peony petal fatty acids and flavonoids and their effect on Caenorhabditis elegans lifespan.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/33092723
 
 
|keywords=* Caenorhabditis elegans
* Fatty acid
* Flavonoid identification and composition
* Lifespan extension
* Tree peony petal
|full-text-url=https://sci-hub.do/10.1016/j.plaphy.2020.06.029
}}
{{medline-entry
|title=Photo aging and fragmentation of polypropylene food packaging materials in artificial seawater.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/33039831
 
 
|keywords=* Aging
* Antioxidant
* Food packaging materials
* Microplastics
* Polypropylene
* seawater
|full-text-url=https://sci-hub.do/10.1016/j.watres.2020.116456
}}
{{medline-entry
|title=Secretory galectin-3 induced by glucocorticoid stress triggers stemness exhaustion of hepatic progenitor cells.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32989051
 
 
|keywords=* AMP-activated kinase (AMPK)
* Cell senescence
* cell cycle
* cellular senescence
* galectin
* galectin-3
* glycoprotein
* liver injury
* proliferation
* protein interaction
* protein-protein interaction
* quiescence
* stem cells
* stemness exhaustion
|full-text-url=https://sci-hub.do/10.1074/jbc.RA120.012974
}}
{{medline-entry
|title=Optimization of Ethanol Detection by Automatic Headspace Method for Cellulose Insulation Aging of Oil-immersed Transformers.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32679756
 
 
|keywords=* aging
* cellulose insulation
* gas chromatography
* headspace sampling
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7407484
}}
{{medline-entry
|title=Sensory, olfactometric and chemical characterization of the aroma potential of Garnacha and Tempranillo winemaking grapes.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32569964
 
|mesh-terms=* Fruit
* Gas Chromatography-Mass Spectrometry
* Hexanols
* Norisoprenoids
* Odorants
* Olfactometry
* Principal Component Analysis
* Sulfhydryl Compounds
* Vitis
* Volatile Organic Compounds
|keywords=* Aging
* Aroma precursors
* Glycosides
* Lipid-derived aroma
* Norisoprenoids
* Sensory properties
* Terpenols
* Volatile phenols
|full-text-url=https://sci-hub.do/10.1016/j.foodchem.2020.127207
}}
{{medline-entry
|title=Accelerated Cognitive Ageing in epilepsy: exploring the effective connectivity between resting-state networks and its relation to cognitive decline.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32529058
 
 
|keywords=* Accelerated cognitive ageing
* Ageing
* Aging
* Biomarkers
* Clinical research
* Cognition
* Cognitive decline
* Cognitive neuroscience
* Effective connectivity
* Epilepsy
* Fmri
* Granger causality
* Image processing
* Medical imaging
* Mental health
* Nervous system
* Neuroscience
* Psychiatry
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7283153
}}
{{medline-entry
|title=Characterization of Jinhua ham aroma profiles in specific to aging time by gas chromatography-ion mobility spectrometry ([[GC]]-IMS).
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32417671
 
 
|keywords=* Aging
* Electronic-nose
* Gas chromatography-ion mobility spectrometry
* Jinhua ham
* Volatiles
|full-text-url=https://sci-hub.do/10.1016/j.meatsci.2020.108178
}}
{{medline-entry
|title=Quantitative Profiling of Lipid Species in Caenorhabditis elegans with Gas Chromatography-Mass Spectrometry.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32410029
 
 
|keywords=* Aging
* C. elegans
* Fat
* Fatty acids
* Gas chromatography–mass spectrometry
* Lipids
* Phospholipids
* Solid-phase chromatography
* Triglycerides
|full-text-url=https://sci-hub.do/10.1007/978-1-0716-0592-9_10
}}
{{medline-entry
|title=Physicochemical characterization of a polysaccharide from Agrocybe aegirita and its anti-ageing activity.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32172871
 
|mesh-terms=* Aging
* Agrocybe
* Antioxidants
* Carbohydrate Sequence
* Cell Line
* Chemical Phenomena
* G1 Phase Cell Cycle Checkpoints
* Humans
* Membrane Potential, Mitochondrial
* Mitochondria
* Polysaccharides
|keywords=* Agrocybe aegirita polysaccharide
* Anti-ageing
* Cell cycle
* Mitochondrial membrane potential
* Structure
|full-text-url=https://sci-hub.do/10.1016/j.carbpol.2020.116056
}}
{{medline-entry
|title=Structural characteristics, antioxidant properties and antiaging activities of galactan produced by Mentha haplocalyx Briq.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32070549
 
|mesh-terms=* Aging
* Animals
* Antioxidants
* Biphenyl Compounds
* Carbohydrate Conformation
* Galactans
* Male
* Mentha
* Mice
* Mice, Inbred Strains
* Particle Size
* Picrates
* Surface Properties
|keywords=* Anti-aging activity
* Antioxidant activity
* Mentha haplocalyx Briq
* Polysaccharides
|full-text-url=https://sci-hub.do/10.1016/j.carbpol.2020.115936
}}
{{medline-entry
|title=Contribution of Volatile Odorous Terpenoid Compounds to Aged Cognac Spirits Aroma in a Context of Multicomponent Odor Mixtures.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32052967
 
 
|keywords=* Cognac
* aging aroma
* lees
* monoterpenes
* perceptual synergic effects
|full-text-url=https://sci-hub.do/10.1021/acs.jafc.9b06656
}}
{{medline-entry
|title=Plasma Formate Is Greater in Fetal and Neonatal Rats Compared with Their Mothers.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31912134
 
|mesh-terms=* Aging
* Animals
* Animals, Newborn
* Female
* Fetus
* Formates
* Liver
* Maternal-Fetal Exchange
* Mothers
* Placenta
* Pregnancy
* Rats
* Rats, Sprague-Dawley
|keywords=* fetus
* glycine
* methionine
* mitochondria
* one-carbon metabolism
* pregnancy
* serine
* tetrahydrofolate
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7198295
}}
{{medline-entry
|title=Development of a new strategy for studying the aroma potential of winemaking grapes through the accelerated hydrolysis of phenolic and aromatic fractions (PAFs).
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31882095
 
 
|keywords=* Aging
* Glycosidic precursors
* Grape aroma
* Grape quality
* Hydrolysis
* Polyphenols
* Wine
|full-text-url=https://sci-hub.do/10.1016/j.foodres.2019.108728
}}
{{medline-entry
|title=Compromised steady-state germinal center activity with age in nonhuman primates.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31840398
 
|mesh-terms=* Aging
* Animals
* Antigens, CD
* B-Lymphocytes
* CD4-Positive T-Lymphocytes
* CD8-Positive T-Lymphocytes
* Forkhead Transcription Factors
* Germinal Center
* Granulocytes
* Immunity, Humoral
* Inflammation
* Lymph Nodes
* Macaca mulatta
* Monocytes
|keywords=* B cells
* Tfh cells
* aging
* follicles
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6996951
}}
{{medline-entry
|title=Endogenous Glucocorticoid Signaling in the Regulation of Bone and Marrow Adiposity: Lessons from Metabolism and Cross Talk in Other Tissues.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31749087
 
|mesh-terms=* Adipose Tissue
* Adiposity
* Animals
* Bone Marrow
* Energy Metabolism
* Glucocorticoids
* Homeostasis
* Humans
* Liver
* Muscle, Skeletal
* Receptor Cross-Talk
* Receptors, Glucocorticoid
* Signal Transduction
* Stress, Physiological
|keywords=* Adipocyte
* Aging
* Bone marrow
* Corticosterone
* Cortisol
* Cortisone
* Glucocorticoid
* Osteoblast
|full-text-url=https://sci-hub.do/10.1007/s11914-019-00554-6
}}
{{medline-entry
|title=4,5-Diphenyl-2-methyl picolinate induces cellular senescence by accumulating DNA damage and activating associated signaling pathways in gastric cancer.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31639393
 
|mesh-terms=* Animals
* Antineoplastic Agents
* Apoptosis
* Cell Cycle
* Cell Proliferation
* Cellular Senescence
* DNA Damage
* Humans
* Mice
* Mice, Inbred BALB C
* Mice, Nude
* Picolinic Acids
* Signal Transduction
* Stomach Neoplasms
* Tumor Cells, Cultured
* Xenograft Model Antitumor Assays
|keywords=* Cellular senescence
* DNA damage
* Gastric cancer
* N-heterocyclic compound
|full-text-url=https://sci-hub.do/10.1016/j.lfs.2019.116973
}}
{{medline-entry
|title=Relationship Between the Dose Administered, Target Tissue Dose, and Toxicity Level After Acute Oral Exposure to Bifenthrin and Tefluthrin in Young Adult Rats.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31573616
 
|mesh-terms=* Administration, Oral
* Aging
* Animals
* Body Temperature
* Cerebellum
* Cyclopropanes
* Dose-Response Relationship, Drug
* Hydrocarbons, Fluorinated
* Liver
* Male
* Pyrethrins
* Rats
* Rats, Wistar
* Tissue Distribution
* Toxicokinetics
|keywords=* acute effects
* bifenthrin
* body temperature
* disposition
* rat
* tefluthrin
|full-text-url=https://sci-hub.do/10.1093/toxsci/kfz204
}}
{{medline-entry
|title=Sugar Beet Pectin Supplementation Did Not Alter Profiles of Fecal Microbiota and Exhaled Breath in Healthy Young Adults and Healthy Elderly.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31547291
 
|mesh-terms=* Aged
* Beta vulgaris
* Breath Tests
* Dietary Supplements
* Double-Blind Method
* Exhalation
* Fatty Acids, Volatile
* Feces
* Female
* Gastrointestinal Microbiome
* Healthy Volunteers
* Humans
* Male
* Pectins
* Volatile Organic Compounds
* Young Adult
|keywords=* aging
* dietary fiber
* elderly
* exhaled air
* microbiota
* pectin
* young adults
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6770243
}}
{{medline-entry
|title=Identification and analysis of new α- and β-hydroxy ketones related to the formation of 3-methyl-2,4-nonanedione in musts and red wines.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31520920
 
|mesh-terms=* Alkanes
* Diacetyl
* Ethanol
* Fruit and Vegetable Juices
* Gas Chromatography-Mass Spectrometry
* Humans
* Hydrogen-Ion Concentration
* Ketones
* Limit of Detection
* Solid Phase Microextraction
* Stereoisomerism
* Time Factors
* Wine
|keywords=* 3-methyl-2,4-nonanedione
* Aroma precursor
* Hydroxy ketones
* Oxidation
* Premature aging
* Wine
|full-text-url=https://sci-hub.do/10.1016/j.foodchem.2019.125486
}}
{{medline-entry
|title=Neonatal T Follicular Helper Cells Are Lodged in a Pre-T Follicular Helper Stage Favoring Innate Over Adaptive Germinal Center Responses.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31456798
 
|mesh-terms=* Adaptive Immunity
* Adjuvants, Immunologic
* Aging
* Animals
* Animals, Newborn
* Germinal Center
* Immunity, Innate
* Interleukin-13
* Lymphopoiesis
* Mice, Inbred C57BL
* T-Lymphocytes, Helper-Inducer
* Th2 Cells
* Transcriptome
|keywords=* T follicular helper cells
* adjuvant
* neonates
* transcriptional profile analysis
* vaccines
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6700230
}}
{{medline-entry
|title=Identification of Dialkylpyrazines Off-Flavors in Oak Wood.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31423769
 
|mesh-terms=* Flavoring Agents
* Gas Chromatography-Mass Spectrometry
* Odorants
* Olfactometry
* Pyrazines
* Quercus
* Wood
|keywords=* aroma
* barrel aging
* dialkylpyrazine
* oak wood
* off-flavor
* wine
|full-text-url=https://sci-hub.do/10.1021/acs.jafc.9b03185
}}
{{medline-entry
|title=Metabolomics Coupled with Transcriptomics Approach Deciphering Age Relevance in Sepsis.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31440390
 
 
|keywords=* aging
* biomarker
* metabolomics
* sepsis
* transcriptomics
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6675524
}}
==GCA==
 
{{medline-entry
|title=Familial aggregation of longevity in giant cell arteritis and polymyalgia rheumatica.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32683496
 
 
|keywords=* Giant cell arteritis
* Longevity
* Mortality
* Polymyalgia rheumatica
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7591435
}}
{{medline-entry
|title=Interaction between Alcohol Consumption and Apolipoprotein E (ApoE) Genotype with Cognition in Middle-Aged Men.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32662384
 
 
|keywords=* Aging
* Alcohol drinking
* Apolipoprotein E4 (ApoE)
* Cognitive abilities
* Male
* Middle aged
* Risk factors
|full-text-url=https://sci-hub.do/10.1017/S1355617720000570
}}
==GCK==
 
{{medline-entry
|title=The Impact of Biomarker Screening and Cascade Genetic Testing on the Cost-Effectiveness of MODY Genetic Testing.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31558549
 
|mesh-terms=* Biomarkers
* Child
* Cost-Benefit Analysis
* Diabetes Mellitus, Type 2
* Female
* Genetic Testing
* Health Care Costs
* Humans
* Life Expectancy
* Male
* Mass Screening
* Pedigree
* Precision Medicine
* Quality-Adjusted Life Years
 
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6868460
}}
==GCLC==
 
{{medline-entry
|title=Aerobic exercise training partially reverses the impairment of Nrf2 activation in older humans.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32866619
 
 
|keywords=* Aging
* Exercise
* GCLC
* NQO1
* Nrf2 signaling
* Redox homeostasis
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7704731
}}
==GCLM==
 
{{medline-entry
|title=Silencing Bach1 alters aging-related changes in the expression of Nrf2-regulated genes in primary human bronchial epithelial cells.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31422075
 
|mesh-terms=* Adult
* Aged
* Aging
* Basic-Leucine Zipper Transcription Factors
* Bronchi
* Epithelial Cells
* Gene Expression
* Gene Silencing
* Glutamate-Cysteine Ligase
* Heme Oxygenase-1
* Humans
* Isothiocyanates
* Middle Aged
* NAD(P)H Dehydrogenase (Quinone)
* NF-E2-Related Factor 2
* RNA, Messenger
* RNA, Small Interfering
* Signal Transduction
* Young Adult
|keywords=* Aging
* Bach1
* Glutamate cysteine ligase
* Heme oxygenase
* Nrf2
* Sulforaphane
|full-text-url=https://sci-hub.do/10.1016/j.abb.2019.108074
}}
==GDF11==
 
{{medline-entry
|title=Growth differentiation factor-11 supplementation improves survival and promotes recovery after ischemic stroke in aged mice.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32365331
 
 
|keywords=* GDF11
* White matter integrity
* aging
* gliosis
* stroke
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7244081
}}
{{medline-entry
|title=Anti-Aging Effects of [[GDF11]] on Skin.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32283613
 
 
|keywords=* disease
* growth factors
* regeneration
* skin aging
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7177281
}}
{{medline-entry
|title=Targeted Approach to Distinguish and Determine Absolute Levels of GDF8 and [[GDF11]] in Mouse Serum.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32104967
 
 
|keywords=* GDF11
* aging
* immunoprecipitation
* myostatin/GDF8
* serum
* targeted-quantitative proteomics
|full-text-url=https://sci-hub.do/10.1002/pmic.201900104
}}
{{medline-entry
|title=Growth differentiation factor 11 impairs titanium implant healing in the femur and leads to mandibular bone loss.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31983062
 
 
|keywords=* aging
* alveolar bone loss
* dental implants
* osseointegration
* transforming growth factors
|full-text-url=https://sci-hub.do/10.1002/JPER.19-0247
}}
{{medline-entry
|title=Systemic [[GDF11]] stimulates the secretion of adiponectin and induces a calorie restriction-like phenotype in aged mice.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31637864
 
 
|keywords=* GDF11
* adiponectin
* aging
* calorie restriction
* heterochronic parabiosis
* rejuvenation
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6974718
}}
{{medline-entry
|title=Circulating factors in young blood as potential therapeutic agents for age-related neurodegenerative and neurovascular diseases.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31400495
 
|mesh-terms=* Age Factors
* Aging
* Animals
* Blood
* Bone Morphogenetic Proteins
* Chemokine CCL11
* Enzyme Therapy
* Enzymes
* Growth Differentiation Factors
* Mice
* Neurodegenerative Diseases
* Parabiosis
* Vascular Diseases
|keywords=* C-C motif chemokine 11
* Circulating factor
* Growth differentiation factor 11
* Neurodegenerative diseases
* Neurovascular diseases
* Young blood
|full-text-url=https://sci-hub.do/10.1016/j.brainresbull.2019.08.004
}}
{{medline-entry
|title=Effects of Exercise Training on Growth and Differentiation Factor 11 Expression in Aged Mice.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31417428
 
 
|keywords=* aging
* exercise
* growth and differentiation factor 11
* sarcopenia
* skeletal muscle
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6684741
}}
==GDF15==
 
{{medline-entry
|title=Disease-specific plasma levels of mitokines FGF21, [[GDF15]], and Humanin in type II diabetes and Alzheimer's disease in comparison with healthy aging.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/33131010
 
 
|keywords=* AD
* Aging
* FGF21
* GDF15
* Humanin
* T2D
|full-text-url=https://sci-hub.do/10.1007/s11357-020-00287-w
}}
{{medline-entry
|title=Growth differentiation factor 15 protects against the aging-mediated systemic inflammatory response in humans and mice.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32691494
 
 
|keywords=* T cell
* aging
* inflammation
* mitochondria
* senescence
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7431835
}}
{{medline-entry
|title=Analysis of Epigenetic Age Predictors in Pain-Related Conditions.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32582603
 
 
|keywords=* DNA methylation
* aging biomarker
* chronic pain
* epigenetic aging
* epigenetic clock
* fibromyalgia
* headache
* pain sensitivity
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7296181
}}
{{medline-entry
|title=[[GDF15]] Plasma Level Is Inversely Associated With Level of Physical Activity and Correlates With Markers of Inflammation and Muscle Weakness.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32477368
 
 
|keywords=* GDF15
* healthy aging
* inflammation
* physical activity
* sedentarity
* skeletal muscle
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7235447
}}
{{medline-entry
|title=[[GDF15]] is an epithelial-derived biomarker of idiopathic pulmonary fibrosis.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31432710
 
|mesh-terms=* Aged
* Alveolar Epithelial Cells
* Animals
* Bleomycin
* Bronchoalveolar Lavage Fluid
* Case-Control Studies
* Disease Models, Animal
* Female
* Gene Expression Profiling
* Growth Differentiation Factor 15
* Humans
* Idiopathic Pulmonary Fibrosis
* Lung
* Male
* Mice
* Middle Aged
* Respiratory Function Tests
* Severity of Illness Index
* Survival Analysis
* Telomere
* Transcriptome
|keywords=* MIC-1
* NAG-1
* SASP
* aging
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6842909
}}
{{medline-entry
|title=Senescence-associated tissue microenvironment promotes colon cancer formation through the secretory factor [[GDF15]].
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31389184
 
|mesh-terms=* Aging
* Cells, Cultured
* Cellular Senescence
* Colonic Neoplasms
* Fibroblasts
* Growth Differentiation Factor 15
* HEK293 Cells
* Humans
* Phenotype
* RNA, Messenger
* Tumor Microenvironment
|keywords=* GDF15
* colon organoids
* colorectal cancer
* microenvironment
* senescence
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6826139
}}
==GDF5==
 
{{medline-entry
|title=An embryonic CaVβ1 isoform promotes muscle mass maintenance via [[GDF5]] signaling in adult mouse.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31694926
 
|mesh-terms=* Adult
* Aged
* Aged, 80 and over
* Aging
* Animals
* Atrophy
* Calcium Channels, L-Type
* Denervation
* Embryo, Mammalian
* Exons
* Female
* Gene Expression Regulation, Developmental
* Growth Differentiation Factor 5
* Humans
* Male
* Mice
* Muscles
* Neuromuscular Junction
* Organ Size
* Physical Conditioning, Animal
* Protein Isoforms
* RNA Splicing
* Signal Transduction
* Young Adult
 
|full-text-url=https://sci-hub.do/10.1126/scitranslmed.aaw1131
}}
==GDNF==
 
{{medline-entry
|title=GFR-α1 Expression in Substantia Nigra Increases Bilaterally Following Unilateral Striatal [[GDNF]] in Aged Rats and Attenuates Nigral Tyrosine Hydroxylase Loss Following 6-OHDA Nigrostriatal Lesion.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31538765
 
|mesh-terms=* Aging
* Animals
* Dopamine
* Glial Cell Line-Derived Neurotrophic Factor
* Glial Cell Line-Derived Neurotrophic Factor Receptors
* Neurons
* Oxidopamine
* Phosphorylation
* Rats
* Substantia Nigra
* Tyrosine 3-Monooxygenase
|keywords=* 6-hydroxydopamine
* Parkinson’s disease
* Substantia nigra
* aging
* nigrostriatal
* tyrosine hydroxylase
|full-text-url=https://sci-hub.do/10.1021/acschemneuro.9b00291
}}
==GEM==
 
{{medline-entry
|title=The Impact of Geriatric Emergency Management Nurses on the Care of Frail Older Patients in the Emergency Department: a Systematic Review.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32904804
 
 
|keywords=* emergency department
* geriatric emergency management nurses
* geriatrics
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7458600
}}
==GFAP==
 
{{medline-entry
|title=Immunohistological Detection of Active Satellite Cellsin Rat Dorsal Root Ganglia after Parenteral Administration of Lipopolysaccharide and during Aging.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32990851
 
 
|keywords=* aging
* dorsal root ganglion
* satellite cells
* systemic inflammation
|full-text-url=https://sci-hub.do/10.1007/s10517-020-04950-2
}}
{{medline-entry
|title=Transgenic Mice Expressing Human α-Synuclein in Noradrenergic Neurons Develop Locus Ceruleus Pathology and Nonmotor Features of Parkinson's Disease.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32868457
 
 
|keywords=* Parkinson's disease
* aging
* locus ceruleus
* nonmotor
* norepinephrine
* α-synuclein
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7511194
}}
{{medline-entry
|title=ApoE Genotype-Dependent Response to Antioxidant and Exercise Interventions on Brain Function.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32630431
 
 
|keywords=* Alzheimer’s disease
* ApoE
* aging
* antioxidants
* cognition
* exercise
* motor
* oxidative stress
* vitamin C
* vitamin E
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7346214
}}
{{medline-entry
|title=Age-Dependent Heterogeneity of Murine Olfactory Bulb Astrocytes.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32581775
 
 
|keywords=* Sholl analysis
* aging
* astrocyte
* cell morphology
* heterogeneity
* olfactory bulb
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7296154
}}
{{medline-entry
|title=Neuroinflammation in Aged Brain: Impact of the Oral Administration of Ellagic Acid Microdispersion.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32455600
 
 
|keywords=* CD45
* EA microdispersion (EAm)
* GFAP
* aging
* behavioral skills
* ellagic acid (EA)
* mice
* noradrenaline
* oral administration
* principal component analysis (PCA)
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7279224
}}
{{medline-entry
|title=Long-term treatment with spermidine increases health span of middle-aged Sprague-Dawley male rats.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32285289
 
 
|keywords=* Autophagy
* Behavior
* Longevity
* Middle-aged rats
* Neuroinflammation
* Spermidine
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7287009
}}
{{medline-entry
|title=Meta-analysis of human prefrontal cortex reveals activation of [[GFAP]] and decline of synaptic transmission in the aging brain.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32138778
 
 
|keywords=* Aging
* Meta-analysis
* Prefrontal cortex
* Sex-specific
* Transcriptome
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7059712
}}
{{medline-entry
|title=Astroglial biotin deprivation under endoplasmic reticulum stress uncouples BCAA-mTORC1 role in lipid synthesis to prolong autophagy inhibition in the aging brain.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32030764
 
 
|keywords=* BCAA
* ER stress
* aging
* autophagy
* lipogenesis
* mTORC1
|full-text-url=https://sci-hub.do/10.1111/jnc.14979
}}
{{medline-entry
|title=Long-lived mice with reduced growth hormone signaling have a constitutive upregulation of hepatic chaperone-mediated autophagy.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32013718
 
 
|keywords=* Aging
* chaperone-mediated autophagy
* endocrine control of autophagy
* endocrine signaling
* growth hormone
|full-text-url=https://sci-hub.do/10.1080/15548627.2020.1725378
}}
{{medline-entry
|title=Lipopolysaccharide exposure during late embryogenesis triggers and drives Alzheimer-like behavioral and neuropathological changes in CD-1 mice.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31997558
 
 
|keywords=* Alzheimer's disease
* aging
* lipopolysaccharide
* memory
* mice
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7066339
}}
{{medline-entry
|title=Increased levels of Aβ42 decrease the lifespan of ob/ob mice with dysregulation of microglia and astrocytes.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31907998
 
|mesh-terms=* Alzheimer Disease
* Amyloid beta-Peptides
* Animals
* Astrocytes
* Gene Knock-In Techniques
* Longevity
* Mice
* Mice, Knockout
* Mice, Obese
* Microglia
* Peptide Fragments
|keywords=* Alzheimer's disease
* astrocytes
* diabetes
* lifespan
* microglia
* obesity
|full-text-url=https://sci-hub.do/10.1096/fj.201901028RR
}}
{{medline-entry
|title=Selective brain neuronal and glial losses without changes in [[GFAP]] immunoreactivity: Young versus mature adult Wistar rats.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31404554
 
|mesh-terms=* Aging
* Animals
* Brain
* Glial Fibrillary Acidic Protein
* Male
* Neuroglia
* Neurons
* Rats
* Rats, Wistar
|keywords=* Ageing
* Astrocytes
* GFAP
* Glia
* Neurons
|full-text-url=https://sci-hub.do/10.1016/j.mad.2019.111128
}}
==GGCT==
 
{{medline-entry
|title=Blockade of γ-Glutamylcyclotransferase Enhances Docetaxel Growth Inhibition of Prostate Cancer Cells.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31519583
 
|mesh-terms=* Antineoplastic Agents
* Apoptosis
* Cell Line, Tumor
* Cell Proliferation
* Cellular Senescence
* Docetaxel
* Enzyme Inhibitors
* Gene Expression
* Humans
* Immunohistochemistry
* Male
* Prostatic Neoplasms
* RNA, Small Interfering
* gamma-Glutamylcyclotransferase
|keywords=* docetaxel
* pro-GA
* prostate cancer cells
* senescence
* γ-glutamylcyclotransferase
|full-text-url=https://sci-hub.do/10.21873/anticanres.13666
}}
==GHR==
 
{{medline-entry
|title=Tissue-Specific [[GHR]] Knockout Mice: An Updated Review.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/33162937
 
 
|keywords=* aging
* growth hormone
* longevity
* metabolism
* mice
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7581730
}}
==GHRH==
 
{{medline-entry
|title=Physiological and metabolic features of mice with CRISPR/Cas9-mediated loss-of-function in growth hormone-releasing hormone.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32422607
 
 
|keywords=* CRISPR
* GHRH
* aging
* lifespan
* metabolism
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7288930
}}
{{medline-entry
|title=Transcriptomic and metabolomic profiling of long-lived growth hormone releasing hormone knock-out mice: evidence for altered mitochondrial function and amino acid metabolism.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32091406
 
 
|keywords=* aging
* growth hormone
* metabolite
* mouse
* transcriptomics
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7066919
}}
==GIP==
 
{{medline-entry
|title=Absence of [[GIP]] secretion alleviates age-related obesity and insulin resistance.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31977316
 
|mesh-terms=* Adiponectin
* Adipose Tissue
* Age Factors
* Animals
* Diet
* Diet, High-Fat
* Enteroendocrine Cells
* Gastric Inhibitory Polypeptide
* Gene Expression
* Glucose Tolerance Test
* Insulin
* Insulin Resistance
* Leptin
* Male
* Mice, Inbred C57BL
* Mice, Knockout
* Mice, Transgenic
* Obesity
|keywords=* GIP
* aging
* incretin
* obesity
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7040458
}}
==GIT2==
 
{{medline-entry
|title=Multidimensional informatic deconvolution defines gender-specific roles of hypothalamic [[GIT2]] in aging trajectories.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31574270
 
|mesh-terms=* Aging
* Animals
* Cluster Analysis
* Computational Biology
* Female
* GTPase-Activating Proteins
* Hypothalamus
* Longevity
* Male
* Mice
* Mice, Inbred C57BL
* RNA
* Sex Characteristics
* Signal Transduction
* Transcriptome
|keywords=* Aging
* Female
* GIT2
* Hypothalamus
* Longevity
|full-text-url=https://sci-hub.do/10.1016/j.mad.2019.111150
}}
==GJC2==
 
{{medline-entry
|title=Zebrafish brain RNA sequencing reveals that cell adhesion molecules are critical in brain aging.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32629311
 
 
|keywords=* Brain aging
* Cell adhesion molecules
* RNA sequencing
* Zebrafish
|full-text-url=https://sci-hub.do/10.1016/j.neurobiolaging.2020.04.017
}}
==GK==
 
{{medline-entry
|title=Progression of diabetic kidney disease in T2DN rats.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31566426
 
|mesh-terms=* Aging
* Albuminuria
* Animals
* Blood Glucose
* Diabetes Mellitus, Type 2
* Diabetic Nephropathies
* Disease Progression
* Hypertrophy
* Kidney Glomerulus
* Male
* Membrane Proteins
* Organ Size
* Polyuria
* Rats
* Rats, Wistar
* Renin-Angiotensin System
* Water-Electrolyte Imbalance
|keywords=* diabetic glomerular disease
* diabetic nephropathy
* podocyte pathology
* renin-angiotensin-aldosterone system
* scanning ion microscopy
* type 2 diabetic nephropathy
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6960784
}}
==GNAQ==
 
{{medline-entry
|title=[[GNAQ]]  expression initiated in multipotent neural crest cells drives aggressive melanoma of the central nervous system.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31680437
 
|mesh-terms=* Aging
* Animals
* Central Nervous System Neoplasms
* Disease Models, Animal
* Disease Progression
* Embryonic Development
* Female
* GTP-Binding Protein alpha Subunits, Gq-G11
* Male
* Melanocytes
* Melanoma
* Meningeal Neoplasms
* Mice, Transgenic
* Multipotent Stem Cells
* Mutation
* Neoplasm Invasiveness
* Neural Crest
* Nevus
* Skin Neoplasms
* Uveal Neoplasms
|keywords=* GNAQ
* Plp1
* blue nevus
* leptomeningeal melanocytoma
* uveal melanoma
|full-text-url=https://sci-hub.do/10.1111/pcmr.12843
}}
==GNE==
 
{{medline-entry
|title=Aberrant mitochondrial morphology and function associated with impaired mitophagy and DNM1L-MAPK/ERK signaling are found in aged mutant Parkinsonian LRRK2  mice.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/33300446
 
 
|keywords=* Aging
* Dnm1l/DRP1
* SQSTM1/p62
* knockin mice
* macroautophagy
* mitochondria dysfunction
* mitochondrial fission
* mitophagy
* parkinson disease
* ubiquitination
|full-text-url=https://sci-hub.do/10.1080/15548627.2020.1850008
}}
==GPC1==
 
{{medline-entry
|title=Decreased expression of [[GPC1]] in human skin keratinocytes and epidermis during ageing.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31430521
 
|mesh-terms=* Adult
* Aged
* Aged, 80 and over
* Aging
* Cell Proliferation
* Cells, Cultured
* Epidermis
* Female
* Fibroblast Growth Factor 2
* Gene Expression Regulation
* Glypicans
* Humans
* Keratinocytes
* Middle Aged
* RNA, Messenger
* Signal Transduction
* Skin
* Young Adult
|keywords=* Ageing
* Epidermis
* Glypican 1
* Human skin
* Keratinocytes
|full-text-url=https://sci-hub.do/10.1016/j.exger.2019.110693
}}
==GPI==
 
{{medline-entry
|title=Blood factors transfer beneficial effects of exercise on neurogenesis and cognition to the aged brain.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32646997
 
|mesh-terms=* Aging
* Animals
* Blood Circulation
* Brain
* Cognition
* Cognitive Dysfunction
* Glycosylphosphatidylinositols
* Liver
* Mice
* Neurogenesis
* Phospholipase D
* Physical Conditioning, Animal
* Regeneration
* Signal Transduction
 
|full-text-url=https://sci-hub.do/10.1126/science.aaw2622
}}
==GPR6==
 
{{medline-entry
|title=Accelerated Epigenetic Aging and Methylation Disruptions Occur in Human Immunodeficiency Virus Infection Prior to Antiretroviral Therapy.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32959881
 
 
|keywords=* HIV
* aging
* epigenetics
* methylation
|full-text-url=https://sci-hub.do/10.1093/infdis/jiaa599
}}
==GPT==
 
{{medline-entry
|title=Brain Structural-Behavioral Correlates Underlying Grooved Pegboard Test Performance Across Lifespan.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32631206
 
 
|keywords=* aging
* gray matter
* visuomotor function
* white matter
|full-text-url=https://sci-hub.do/10.1080/00222895.2020.1787320
}}
==GPX1==
 
{{medline-entry
|title=Glutathione peroxidase-1 overexpression reduces oxidative stress, and improves pathology and proteome remodeling in the kidneys of old mice.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32400101
 
 
|keywords=* glutathione peroxidase-1
* kidney aging
* mitochondria
* proteomics
* reactive oxygen species
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7294784
}}
==GPX3==
 
{{medline-entry
|title=Long noncoding RNA glutathione peroxidase 3-antisense inhibits lens epithelial cell apoptosis by upregulating glutathione peroxidase 3 expression in age-related cataract.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31814699
 
|mesh-terms=* Aging
* Anterior Capsule of the Lens
* Apoptosis
* Cataract
* Cell Line
* Cell Nucleus
* Epithelial Cells
* Glutathione Peroxidase
* Humans
* Hydrogen Peroxide
* Lens, Crystalline
* RNA, Long Noncoding
* Up-Regulation
 
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6857780
}}
==GPX4==
 
{{medline-entry
|title=l-carnitine supplementation during in vitro culture regulates oxidative stress in embryos from bovine aged oocytes.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31837632
 
|mesh-terms=* Animals
* Carnitine
* Cattle
* Culture Media
* Embryo Culture Techniques
* Female
* Fertilization in Vitro
* In Vitro Oocyte Maturation Techniques
* Oocytes
* Oxidative Stress
|keywords=* Bovine
* Embryo development
* Oocyte aging
* l-carnitine
|full-text-url=https://sci-hub.do/10.1016/j.theriogenology.2019.11.036
}}
{{medline-entry
|title=Dietary Selenium Supplementation Ameliorates Female Reproductive Efficiency in Aging Mice.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31835711
 
 
|keywords=* GPX4
* Gpx1
* Gpx3
* Selenof
* apoptosis
* embryo
* follicle development
* ovarian aging
* selenium
* selenoprotein
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6969897
}}
==GREM1==
 
{{medline-entry
|title=[[GREM1]] inhibits osteogenic differentiation, senescence and BMP transcription of adipose-derived stem cells.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32151168
 
 
|keywords=* BMP
* GREM1
* adipose-derived stem cells (ADSCs)
* osteogenic differentiation
* senescence
|full-text-url=https://sci-hub.do/10.1080/03008207.2020.1736054
}}
==GREM2==
 
{{medline-entry
|title=Increase of gremlin 2 with age in human adipose-derived stromal/stem cells and its inhibitory effect on adipogenesis.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31709279
 
 
|keywords=* Adipogenic differentiation
* Adipose-derived stromal/stem stem cells
* Aging
* DAPI, 4′,6-diamidino-2-phenylindole
* FGF, fibroblast growth factor
* GREM2
* GREM2 knockdown
* HE, hematoxylin eosin
* Individual differences
* PBS, phosphate buffered Solution
* PFA, paraformaldehyde
* TGF-β, transforming growth factor beta
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6831850
}}
==GRID1==
 
{{medline-entry
|title=Gene discovery for high-density lipoprotein cholesterol level change over time in prospective family studies.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32109663
 
 
|keywords=* GWAS
* HDL-C metabolism
* Healthy aging
* Longevity
* Longitudinal HDL-C change
|full-text-url=https://sci-hub.do/10.1016/j.atherosclerosis.2020.02.005
}}
==GRIK2==
 
{{medline-entry
|title=Senescence of Normal Human Fibroblasts Relates to the Expression of Ionotropic Glutamate Receptor GluR6/Grik2.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/33099472
 
 
|keywords=* GluR6
* Grik2
* Senescence
* cancer
* glutamate receptor
* normal fibroblasts
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7675648
}}
==GRK2==
 
{{medline-entry
|title=G protein-coupled receptor kinase 2 modifies the ability of Caenorhabditis elegans to survive oxidative stress.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/33064264
 
 
|keywords=* Aging
* Caenorhabditis elegans (C. elegans)
* G protein coupled receptor kinase (GRK)
* Oxidative stress
* Resistance
* Stress response
|full-text-url=https://sci-hub.do/10.1007/s12192-020-01168-z
}}
{{medline-entry
|title=G protein coupled receptor kinases modulate Caenorhabditis elegans reactions to heat stresses.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32768194
 
 
|keywords=* Aging
* Biological control
* Caenorhabditis elegans (C. elegans)
* G protein coupled receptor (GPCR)
* G protein coupled receptor kinase (GRK)
* Heat stress
* Resistance
* Stress response
|full-text-url=https://sci-hub.do/10.1016/j.bbrc.2020.07.121
}}
{{medline-entry
|title=Loss of dynamic regulation of G protein-coupled receptor kinase 2 by nitric oxide leads to cardiovascular dysfunction with aging.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32216616
 
|mesh-terms=* Aging
* Animals
* Female
* G Protein-Coupled Inwardly-Rectifying Potassium Channels
* Heart
* Heart Diseases
* Homeostasis
* Male
* Mice
* Mutation
* Myocardium
* Nitric Oxide
|keywords=* S-nitrosylation
* cardiac hypertrophy
* heart disease
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7346533
}}
==GRM3==
 
{{medline-entry
|title=Profiling gene expression in the human dentate gyrus granule cell layer reveals insights into schizophrenia and its genetic risk.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32203495
 
|mesh-terms=* Adolescent
* Adult
* Aged
* Aged, 80 and over
* Aging
* Bipolar Disorder
* Dentate Gyrus
* Depressive Disorder, Major
* Female
* Gene Expression Profiling
* Genetic Predisposition to Disease
* Genome-Wide Association Study
* Humans
* Male
* Middle Aged
* Neurons
* Quantitative Trait Loci
* Schizophrenia
* Transcriptome
* Young Adult
 
|full-text-url=https://sci-hub.do/10.1038/s41593-020-0604-z
}}
==GRN==
 
{{medline-entry
|title=Stressful development: Integrating endoderm development, stress, and longevity.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/33307045
 
 
|keywords=* Caenorhabditis elegans
* Embryonic development
* Epigenetics inheritance
* Innate immunity
* Longevity
* Pleiotropy
* Stress
|full-text-url=https://sci-hub.do/10.1016/j.ydbio.2020.12.002
}}
{{medline-entry
|title=A Scoping Review of the Evidence About the Nurses Improving Care for Healthsystem Elders (NICHE) Program.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31681955
 
 
|keywords=* Aging
* Geriatric nursing
* Health care professionals
* Intervention
* Quality improvement
|full-text-url=https://sci-hub.do/10.1093/geront/gnz150
}}
==GSC==
 
{{medline-entry
|title=[i]mastermind[/i] regulates niche ageing independently of the [i]Notch[/i] pathway in the [i]Drosophila[/i] ovary.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31744422
 
|mesh-terms=* Aging
* Animals
* Cellular Senescence
* Drosophila Proteins
* Drosophila melanogaster
* Female
* Germ Cells
* Nuclear Proteins
* Ovary
* Receptors, Notch
* Signal Transduction
* Stem Cell Niche
* Transcriptome
|keywords=* DE-cadherin
* Drosophila oogenesis
* Hedgehog
* mastermind
* niche ageing
* reactive oxygen species
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6893403
}}
==GSTM1==
 
{{medline-entry
|title=The effects of everyday-life exposure to polycyclic aromatic hydrocarbons on biological age indicators.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/33272294
 
 
|keywords=* Biological aging
* DNA adduct
* Mitochondrial DNA copy number
* Polycyclic aromatic hydrocarbon
* Structural equation modelling
* Telomere length
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7713168
}}
==GSTM2==
 
{{medline-entry
|title=Small Extracellular Vesicles Have GST Activity and Ameliorate Senescence-Related Tissue Damage.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32574561
 
 
|keywords=* 4-HNE
* EV
* GSH
* GST
* ROS
* SASP
* aging
* extracellular vesicles
* glutathione metabolism
* glutathione-S-transferase
* lipid peroxidation
* rejuvenation
* senescence
* senescence-associated secretory phenotype
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7342013
}}
==GUK1==
 
{{medline-entry
|title=Characterization of the impact of GMP/GDP synthesis inhibition on replicative lifespan extension in yeast.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32232569
 
 
|keywords=* Aging
* GDP
* GMP
* Mycophenolic acid
* Proteasome
* Replicative lifespan
* Yeast
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7367712
}}
==GZMK==
 
{{medline-entry
|title=Comprehensive Profiling of an Aging Immune System Reveals Clonal [[GZMK]]  CD8  T Cells as Conserved Hallmark of Inflammaging.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/33271118
 
 
|keywords=* Aging
* CD8 T cells
* CITE-seq
* granzyme K
* immune system
* inflammaging
* single-cell ATAC-sequencing
* single-cell BCR-sequencing
* single-cell RNA-sequencing
* single-cell TCR-sequencing
|full-text-url=https://sci-hub.do/10.1016/j.immuni.2020.11.005
}}
==H2AX==
 
{{medline-entry
|title=Evaluation of Gamma[[H2AX]] in Buccal Cells as a Molecular Biomarker of DNA Damage in Alzheimer's Disease in the AIBL Study of Ageing.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32781776
 
 
|keywords=* Alzheimer’s disease
* DNA damage
* mild cognitive impairment
* senescence
* γH2AX
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7459751
}}
{{medline-entry
|title=Cisplatin-induced peripheral neuropathy is associated to neuronal senescence-like response.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32597980
 
 
|keywords=* cisplatin
* neuropathy
* neurotoxicity
* p21
* senescence
|full-text-url=https://sci-hub.do/10.1093/neuonc/noaa151
}}
{{medline-entry
|title=Guanine Deaminase Stimulates Ultraviolet-induced Keratinocyte Senescence in Seborrhoeic Keratosis via Guanine Metabolites.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32215662
 
 
|keywords=*  DNA damage
*  UV-induced keratinocyte senescence
*  guanine deaminase
*  reactive oxygen species
*  uric acid
* seborrhoeic keratosis
|full-text-url=https://sci-hub.do/10.2340/00015555-3473
}}
{{medline-entry
|title=Do BRCA1 and BRCA2 gene mutation carriers have a reduced ovarian reserve? Protocol for a prospective observational study.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31772111
 
|mesh-terms=* Adolescent
* Adult
* Aging
* BRCA1 Protein
* BRCA2 Protein
* Female
* Germ-Line Mutation
* Heterozygote
* Humans
* Immunohistochemistry
* Middle Aged
* Observational Studies as Topic
* Ovarian Follicle
* Ovarian Reserve
* Prospective Studies
* Research Design
* Young Adult
|keywords=* BRCA
* DNA repair
* fertility
* follicle
* germline mutation
* oocyte
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6887091
}}
{{medline-entry
|title=Slower rates of accumulation of DNA damage in leukocytes correlate with longer lifespans across several species of birds and mammals.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31730540
 
|mesh-terms=* Animals
* Birds
* Bottle-Nosed Dolphin
* Cross-Sectional Studies
* DNA Damage
* Goats
* Leukocytes
* Longevity
* Reindeer
* Turtles
* Vertebrates
|keywords=* DNA damage
* lifespan
* short telomeres
* species
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6874430
}}
{{medline-entry
|title=Phosphoproteomic analysis reveals plant DNA damage signalling pathways with a functional role for histone [[H2AX]] phosphorylation in plant growth under genotoxic stress.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31410901
 
|mesh-terms=* ATP-Binding Cassette Transporters
* Aging
* Arabidopsis
* Arabidopsis Proteins
* Cells, Cultured
* DNA Damage
* DNA Repair
* Gene Expression Regulation, Plant
* Gene Ontology
* Germination
* Histones
* Mass Spectrometry
* Phosphorylation
* Proteome
* Seeds
* Serine
* Signal Transduction
* Stress, Physiological
* X-Rays
|keywords=* ATAXIA TELANGIECTASIA MUTATED (ATM)
* DNA damage response
* DNA repair
* phosphorylation
* seed
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6900162
}}
==HBM==
 
{{medline-entry
|title=The effects of dietary fatty acids on bone, hematopoietic marrow and marrow adipose tissue in a murine model of senile osteoporosis.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31553309
 
|mesh-terms=* Adipose Tissue
* Adiposity
* Animals
* Bone Density
* Bone Marrow
* Dietary Fats
* Dietary Supplements
* Disease Models, Animal
* Fatty Acids, Omega-3
* Female
* Femur
* Mice
* Osteoporosis
* X-Ray Microtomography
|keywords=* SAMP8 mouse
* aging
* fish oil
* marrow adipose tissue
* osteoporosis
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6781972
}}
==HBP1==
 
{{medline-entry
|title=Suppression of p38/[[HBP1]] pathway alleviates hyperosmotic stress-induced senescent progression of chondrocyte senescence.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32549582
 
|mesh-terms=* Cellular Senescence
* Chondrocytes
* Disease Progression
* High Mobility Group Proteins
* Humans
* Osteoarthritis
* Repressor Proteins
* Up-Regulation
* p38 Mitogen-Activated Protein Kinases
|keywords=* HBP1
* chondrocyte
* osmolality stress
* p38
* senescence
|full-text-url=https://sci-hub.do/10.23812/20-63-A-6
}}
==HCN1==
 
{{medline-entry
|title=Protein expression changes of [[HCN1]] and HCN2 in hippocampal subregions of gerbils during the normal aging process.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32128096
 
 
|keywords=* Aging
* Dentate gyrus
* Granule cells
* HCN channel
* Hippocampus proper
* Pyramidal cells
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7038419
}}
==HDAC1==
 
{{medline-entry
|title=[[HDAC1]] modulates OGG1-initiated oxidative DNA damage repair in the aging brain and Alzheimer's disease.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32424276
 
|mesh-terms=* Acetylation
* Aging
* Alzheimer Disease
* Animals
* Astrocytes
* Base Sequence
* Benzophenones
* Brain
* Cognition
* Cognition Disorders
* DNA Damage
* DNA Glycosylases
* Down-Regulation
* Gene Ontology
* Guanine
* Histone Deacetylase 1
* Memory
* Mice, Inbred C57BL
* Mice, Knockout
* Neurons
* Oxidative Stress
* Promoter Regions, Genetic
 
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7235043
}}
==HDAC10==
 
{{medline-entry
|title=Middle-aged female rats lack changes in histone H3 acetylation in the anterior hypothalamus observed in young females on the day of a luteinizing hormone surge.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31434815
 
|mesh-terms=* Acetylation
* Age Factors
* Animals
* Estradiol
* Female
* Histones
* Hypothalamus, Anterior
* Luteinizing Hormone
* Rats
* Rats, Sprague-Dawley
|keywords=* Histone acetylation
* LH
* aging
* histone deacetylases
* hypothalamus
|full-text-url=https://sci-hub.do/10.5582/bst.2019.01162
}}
==HDAC2==
 
{{medline-entry
|title=EEF1A1 deacetylation enables transcriptional activation of remyelination.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32647127
 
|mesh-terms=* Acetylation
* Aging
* Animals
* Cell Dedifferentiation
* Cell Nucleus
* Histone Deacetylase 1
* Histone Deacetylase 2
* Lysine Acetyltransferase 5
* Mice
* Models, Biological
* Oligodendroglia
* Peptide Elongation Factor 1
* Peripheral Nervous System
* Recovery of Function
* Remyelination
* SOXE Transcription Factors
* STAT3 Transcription Factor
* Schwann Cells
* Theophylline
* Trans-Activators
* Transcriptional Activation
 
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7347577
}}
==HDAC3==
 
{{medline-entry
|title=Histone deacetylase-3: Friend and foe of the brain.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32486848
 
 
|keywords=* Histone deacetylases
* aging
* histone deacetylase-3
* learning and memory
* neurodegenerative diseases
* neurodevelopment
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7400723
}}
{{medline-entry
|title=Loss of [[HDAC3]] contributes to meiotic defects in aged oocytes.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31498540
 
|mesh-terms=* Animals
* Cells, Cultured
* Cellular Senescence
* Female
* Histone Deacetylases
* Meiosis
* Mice
* Mice, Inbred ICR
* Oocytes
|keywords=* HDACs
* aneuploidy
* maternal aging
* oocyte quality
* reproduction
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6826132
}}
==HDAC4==
 
{{medline-entry
|title=The posttranslational modification of [[HDAC4]] in cell biology: Mechanisms and potential targets.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31588631
 
 
|keywords=* HDAC4
* cell senescence
* cellular apoptosis and autophagy
* glucose metabolism
* inflammation and pathology
* proliferation and differentiation
|full-text-url=https://sci-hub.do/10.1002/jcb.29365
}}
==HDAC6==
 
{{medline-entry
|title=Inhibition of [[HDAC6]] Attenuates Diabetes-Induced Retinal Redox Imbalance and Microangiopathy.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32660051
 
 
|keywords=* HDAC6
* diabetic retinopathy
* oxidative stress
* retinal endothelial cell senescence
* retinal endothelial cells
* tubastatin A
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7402090
}}
==HDC==
 
{{medline-entry
|title=Induced pluripotency and spontaneous reversal of cellular aging in supercentenarian donor cells.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32115145
 
|mesh-terms=* Adult
* Aged, 80 and over
* Cell Differentiation
* Cell Line
* Cellular Reprogramming
* Cellular Senescence
* Child
* Clone Cells
* Gene Expression Regulation
* Humans
* Induced Pluripotent Stem Cells
* Mesenchymal Stem Cells
* Telomere Homeostasis
* Tissue Donors
* Transcriptome
|keywords=* Aging
* Longevity
* Reprogramming
* Supercentenarian
* Telomere
* iPSC
|full-text-url=https://sci-hub.do/10.1016/j.bbrc.2020.02.092
}}
==HES1==
 
{{medline-entry
|title=A Single-Cell Transcriptomic Atlas of Human Skin Aging.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/33238152
 
 
|keywords=* HES1
* KLF6
* aging
* fibroblast
* keratinocyte
* quercetin
* senescence
* single-cell RNA sequencing
* skin
|full-text-url=https://sci-hub.do/10.1016/j.devcel.2020.11.002
}}
==HFE==
 
{{medline-entry
|title=Polyphenol Characterization and Skin-Preserving Properties of Hydroalcoholic Flower Extract from [i]Himantoglossum robertianum[/i] (Orchidaceae).
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31739534
 
 
|keywords=* Himantoglossum robertianum
* antioxidants
* collagenase
* elastase
* flavonoids
* keratinocytes
* skin aging
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6918203
}}
==HGD==
 
{{medline-entry
|title=High-glucose diets induce mitochondrial dysfunction in Caenorhabditis elegans.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31846489
 
|mesh-terms=* Animals
* Caenorhabditis elegans
* Diet
* Gene Expression Regulation
* Glucose
* Longevity
* Mitochondria
* Mitophagy
 
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6917275
}}
==HGF==
 
{{medline-entry
|title=Age-related changes in the immunomodulatory effects of human dental pulp derived mesenchymal stem cells on the CD4  T cell subsets.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/33223447
 
 
|keywords=* Aging
* CD4 T cell
* Dental pulp
* Immunomodulation
* Mesenchymal stem cell
|full-text-url=https://sci-hub.do/10.1016/j.cyto.2020.155367
}}
{{medline-entry
|title=Hepatocyte growth factor ([[HGF]]) and stem cell factor (SCF) maintained the stemness of human bone marrow mesenchymal stem cells (hBMSCs) during long-term expansion by preserving mitochondrial function via the PI3K/AKT, ERK1/2, and STAT3 signaling pathways.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32736659
 
 
|keywords=* Hepatocyte growth factor
* Mitochondrial function
* Osteogenic differentiation
* Senescence
* Stem cell factor
* Stem cells from human exfoliated deciduous teeth
* Stemness
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7393921
}}
{{medline-entry
|title=Phenytoin sodium-ameliorated gingival fibroblast aging is associated with autophagy.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32281104
 
 
|keywords=* aging
* autophagy
* gingival fibroblast
* phenytoin sodium
|full-text-url=https://sci-hub.do/10.1111/jre.12750
}}
{{medline-entry
|title=Impaired integrin α  /β  -mediated hepatocyte growth factor release by stellate cells of the aged liver.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32157808
 
 
|keywords=* aging
* hepatic stellate cells
* integrins
* laminins
* mechanobiology
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7189994
}}
==HGS==
 
{{medline-entry
|title=Handgrip strength asymmetry is associated with future falls in older Americans.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/33247424
 
 
|keywords=* Aging
* Functional laterality
* Geriatric assessment
* Geriatrics
* Muscle strength dynamometer
|full-text-url=https://sci-hub.do/10.1007/s40520-020-01757-z
}}
{{medline-entry
|title=Examining Additional Aspects of Muscle Function with a Digital Handgrip Dynamometer and Accelerometer in Older Adults: A Pilot Study.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/33142897
 
 
|keywords=* aging
* geriatric assessment
* muscle strength
* muscle weakness
* physical functional performance
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7709634
}}
{{medline-entry
|title=The Relationship between Muscular Strength and Depression in Older Adults with Chronic Disease Comorbidity.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32962093
 
 
|keywords=* aging
* depression
* disease comorbidities
* muscular strength
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7558624
}}
{{medline-entry
|title=Handgrip Strength in the Korean Population: Normative Data and Cutoff Values.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32743310
 
 
|keywords=* Aging
* Hand strength
* Muscle strength
* Nutrition surveys
* Sarcopenia
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7370763
}}
{{medline-entry
|title=Handgrip Strength Asymmetry and Weakness Are Associated with Lower Cognitive Function: A Panel Study.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32473060
 
 
|keywords=* aging
* functional laterality
* geriatric assessment
* geriatrics
* muscle strength dynamometer
|full-text-url=https://sci-hub.do/10.1111/jgs.16556
}}
{{medline-entry
|title=Handgrip Strength Asymmetry and Weakness are Differentially Associated with Functional Limitations in Older Americans.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32384713
 
|mesh-terms=* Aged
* Aged, 80 and over
* Female
* Geriatric Assessment
* Hand Strength
* Humans
* Male
* Middle Aged
* Muscle Strength
* Muscle Strength Dynamometer
* Muscle Weakness
* Odds Ratio
* United States
|keywords=* aging
* geriatrics
* muscle strength
* muscle strength dynamometer
* nutrition surveys
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7246814
}}
{{medline-entry
|title=Absolute and Body Mass Index Normalized Handgrip Strength Percentiles by Gender, Ethnicity, and Hand Dominance in Americans.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31930203
 
 
|keywords=* aging
* epidemiology
* hand strength
* human development
* muscle weakness
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6954001
}}
{{medline-entry
|title=Hand grip strength variability during serial testing as an entropic biomarker of aging: a Poincaré plot analysis.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31931730
 
|mesh-terms=* Aged
* Aged, 80 and over
* Aging
* Biomarkers
* Cross-Sectional Studies
* Entropy
* Female
* Hand Strength
* Heart Rate
* Humans
* Male
|keywords=* Aging
* Entropy
* Hand grip strength
* Nonlinear dynamics
* Poincaré plot
* Time series
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6958685
}}
{{medline-entry
|title=Physical Activity and Fitness in White- and Blue-Collar Retired Men.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31849269
 
|mesh-terms=* Aged
* Aged, 80 and over
* Aging
* Body Mass Index
* Exercise
* Geriatric Assessment
* Humans
* Longitudinal Studies
* Male
* Men's Health
* Occupations
* Physical Fitness
* Poland
* Retirement
* Social Class
* Surveys and Questionnaires
* Task Performance and Analysis
|keywords=* Retirement
* occupation
* old men
* physical activity
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6920597
}}
{{medline-entry
|title=Association between Hand Grip Strength and Self-Rated Health in Middle- and Old-Aged Korean Citizens.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31842533
 
 
|keywords=* Hand Grip Strength
* Korean Longitudinal Study of Aging
* Self-Rated Health
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6987025
}}
{{medline-entry
|title=Weakness May Have a Causal Association With Early Mortality in Older Americans: A Matched Cohort Analysis.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31786197
 
 
|keywords=* Aging
* Epidemiology
* Geriatrics
* hand strength
* muscle strength
* sarcopenia
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7186143
}}
{{medline-entry
|title=Associations Between Dietary Patterns and Handgrip Strength: The Korea National Health and Nutrition Examination Survey 2014-2016.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31743070
 
 
|keywords=* Dietary patterns
* Korea National Health and Nutrition Examination Survey
* aging
* diet
* handgrip strength
|full-text-url=https://sci-hub.do/10.1080/07315724.2019.1691955
}}
{{medline-entry
|title=Effect of relative handgrip strength on cardiovascular disease among Korean adults aged 45 years and older: Results from the Korean Longitudinal Study of Aging (2006-2016).
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31574451
 
|mesh-terms=* Adult
* Aged
* Aged, 80 and over
* Aging
* Cardiovascular Diseases
* Female
* Hand Strength
* Humans
* Longitudinal Studies
* Male
* Middle Aged
* Muscle Strength
* Muscle, Skeletal
* Republic of Korea
* Risk Factors
|keywords=* Cardiovascular disease
* KLoSA
* Relative handgrip strength
|full-text-url=https://sci-hub.do/10.1016/j.archger.2019.103937
}}
{{medline-entry
|title=Weakness and cognitive impairment are independently and jointly associated with functional decline in aging Americans.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31520335
 
|mesh-terms=* Activities of Daily Living
* Aged
* Aging
* Cognitive Dysfunction
* Geriatric Assessment
* Hand Strength
* Humans
* Middle Aged
|keywords=* Dementia
* Epidemiology
* Geriatrics
* Muscle strength
* Nervous system
|full-text-url=https://sci-hub.do/10.1007/s40520-019-01351-y
}}
{{medline-entry
|title=Association of phase angle with sarcopenia and its components in physically active older women.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31463928
 
|mesh-terms=* Aged
* Cross-Sectional Studies
* Electric Impedance
* Female
* Hand Strength
* Humans
* Muscle Strength
* Sarcopenia
* Walking Speed
|keywords=* Aging
* Bioimpedance
* Muscle function
* Muscle mass
|full-text-url=https://sci-hub.do/10.1007/s40520-019-01325-0
}}
==HLA-DRB1==
 
{{medline-entry
|title=The pathophysiology of polymyalgia rheumatica, small pieces of a big puzzle.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32942037
 
 
|keywords=* Aging
* B cell
* HLA-DR
* Interleukin-6
* Polymyalgia rheumatica
* T cell
|full-text-url=https://sci-hub.do/10.1016/j.autrev.2020.102670
}}
==HMGA1==
 
{{medline-entry
|title=Characterization of [i][[HMGA1]]P6[/i] transgenic mouse embryonic fibroblasts.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32787507
 
 
|keywords=* CeRNA
* HMGA1
* HMGA1P6
* pseudogenes
* senescence
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7513866
}}
==HMGA2==
 
{{medline-entry
|title=4D Genome Rewiring during Oncogene-Induced and Replicative Senescence.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32220303
 
|mesh-terms=* Cells, Cultured
* Cellular Senescence
* Chromatin Assembly and Disassembly
* DNA (Cytosine-5-)-Methyltransferase 1
* DNA Methylation
* Fibroblasts
* Genome, Human
* Heterochromatin
* Humans
* In Situ Hybridization, Fluorescence
* Oncogenes
|keywords=* 3D genome architecture
* DNMT1
* Hi-C
* chromatin compartments
* gene regulation
* oncogene-induced senescence
* replicative senescence
* senescence
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7208559
}}
{{medline-entry
|title=The protective effects of [[HMGA2]] in the senescence process of bone marrow-derived mesenchymal stromal cells.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32068957
 
 
|keywords=* bone marrow derived mesenchymal stromal cells (MSCs)
* high-mobility group AT-hook 2 (HMGA2)
* regulator of G protein signaling 2 (Rgs2)
* senescence
|full-text-url=https://sci-hub.do/10.1002/term.3023
}}
==HMGB1==
 
{{medline-entry
|title=Senescent human melanocytes drive skin ageing via paracrine telomere dysfunction.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31633821
 
|mesh-terms=* Adult
* Aged
* Aged, 80 and over
* Aging
* Atrophy
* Cells, Cultured
* Cellular Senescence
* Cyclin-Dependent Kinase Inhibitor p16
* Epidermis
* Female
* Humans
* Male
* Melanocytes
* Middle Aged
* Paracrine Communication
* Reactive Oxygen Species
* Receptors, CXCR4
* Skin
* Telomere
* Young Adult
|keywords=*
SASP
 
* melanocytes
* senescence
* skin ageing
* telomeres
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6885734
}}
==HMGCR==
 
{{medline-entry
|title=Cholesterol Homeostasis: An In Silico Investigation into How Aging Disrupts Its Key Hepatic Regulatory Mechanisms.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/33007859
 
 
|keywords=* aging
* cholesterol biosynthesis
* mathematical model
* reactive oxygen species
* systems biology
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7599957
}}
{{medline-entry
|title=Artesunate inhibits the mevalonate pathway and promotes glioma cell senescence.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31746143
 
 
|keywords=* artesunate
* distant seeding
* glioma
* mevalonate pathway
* senescence
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6933330
}}
==HOXD8==
 
{{medline-entry
|title=Single-Cell Transcriptome Analysis Reveals Six Subpopulations Reflecting Distinct Cellular Fates in Senescent Mouse Embryonic Fibroblasts.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32849838
 
 
|keywords=* Hoxd8
* cellular senescence
* mouse embryonic fibroblasts
* senescence-associated secretory phenotype
* single-cell RNA sequencing
* transcriptomic heterogeneity
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7431633
}}
==HP==
 
{{medline-entry
|title=A narrative review of highly processed food addiction across the lifespan.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/33127423
 
 
|keywords=* Adolescence
* Adulthood
* Childhood
* Food addiction
* Infancy
* Lifespan
* Prenatal
|full-text-url=https://sci-hub.do/10.1016/j.pnpbp.2020.110152
}}
{{medline-entry
|title=Beta Human Papillomavirus 8E6 Attenuates LATS Phosphorylation after Failed Cytokinesis.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32238586
 
|mesh-terms=* Apoptosis
* Cell Cycle Proteins
* Cell Line, Tumor
* Cell Proliferation
* Cell Survival
* Cytochalasin B
* Cytokinesis
* DNA Repair
* E1A-Associated p300 Protein
* Gene Expression Regulation
* HCT116 Cells
* Host-Pathogen Interactions
* Humans
* Keratinocytes
* Oncogene Proteins, Viral
* Osteoblasts
* Papillomaviridae
* Phenotype
* Phosphorylation
* Primary Cell Culture
* Protein-Serine-Threonine Kinases
* Signal Transduction
* Transcription Factors
* Tumor Suppressor Protein p53
|keywords=* Hippo signaling pathway
* apoptosis
* cancer
* cytokinesis
* human papillomavirus
* senescence
* skin cancer
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7307087
}}
==HPSE==
 
{{medline-entry
|title=Distribution of heparan sulfate correlated with the expression of heparanase-1 and matrix metalloproteinase-9 in an ovariectomized rats skin.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32159248
 
 
|keywords=* aging
* estrogen
* extracellular matrix
* heparan sulfate
* heparanase-1
* matrix metalloproteinase-9
|full-text-url=https://sci-hub.do/10.1002/cbin.11339
}}
==HR==
 
{{medline-entry
|title=Patients with hip fracture and total hip arthroplasty surgery differ in anthropometric, but not cardiovascular screening abnormalities.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/33267795
 
 
|keywords=* Aging
* Cardiovascular reactivity
* Heart rate variability
* Hip fracture
* Total hip arthroplasty
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7713041
}}
{{medline-entry
|title=Clinical Role of Lung Ultrasound for the Diagnosis and Prognosis of Coronavirus Disease Pneumonia in Elderly Patients: A Pivotal Study.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/33271558
 
 
|keywords=* Aging
* Coronavirus disease
* Elderly
* Lung ultrasound
* Severe acute respiratory syndrome-coronavirus-2
|full-text-url=https://sci-hub.do/10.1159/000512209
}}
{{medline-entry
|title=The Relationship of Accelerometer-Assessed Standing Time With and Without Ambulation and Mortality: The WHI OPACH Study.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/33225345
 
 
|keywords=* Accelerometer
* Longevity
* Physical activity
|full-text-url=https://sci-hub.do/10.1093/gerona/glaa227
}}
{{medline-entry
|title=Age-related myofiber atrophy in old mice is reversed by ten weeks voluntary high-resistance wheel running.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/33181317
 
 
|keywords=* Aging
* Exercise
* Mouse model
* Muscle morphology
* Skeletal muscle
* Training
|full-text-url=https://sci-hub.do/10.1016/j.exger.2020.111150
}}
{{medline-entry
|title=Predicted Skeletal Muscle Mass and 4-Year Cardiovascular Disease Incidence in Middle-Aged and Elderly Participants of IKARIA Prospective Epidemiological Study: The Mediating Effect of Sex and Cardiometabolic Factors.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/33121164
 
 
|keywords=* aging
* body composition
* gender
* heart disease
* lean mass
* obesity
* primary prevention
* women
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7693172
}}
{{medline-entry
|title=Obesity is associated with early hip fracture risk in postmenopausal women: a 25-year follow-up.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/33095419
 
 
|keywords=* Aging
* Body mass index
* Bone mineral density
* Follow-up study
* General population
* Hip fracture
* Menopause
* Obesity
|full-text-url=https://sci-hub.do/10.1007/s00198-020-05665-w
}}
{{medline-entry
|title=ATM inhibition synergizes with fenofibrate in high grade serous ovarian cancer cells.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/33024871
 
 
|keywords=* Biochemistry
* Bioinformatics
* Cancer research
* Cell biology
* Cellular metabolism
* Cellular senescence
* Drug combinations
* Homologous recombination
* Metabolite
* Molecular biology
* PPARa
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7527645
}}
{{medline-entry
|title=Effectiveness of adjuvant FOLFOX vs 5FU/LV in adults over age 65 with stage II and III colon cancer using a novel hybrid approach.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/33015888
 
 
|keywords=* aging
* cancer
* chemotherapy
* comparative effectiveness research
* pharmacoepidemiology
|full-text-url=https://sci-hub.do/10.1002/pds.5148
}}
{{medline-entry
|title=Age, Frailty, and Comorbidity as Prognostic Factors for Short-Term Outcomes in Patients With Coronavirus Disease 2019 in Geriatric Care.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32978065
 
|mesh-terms=* Age Factors
* Aged
* Aged, 80 and over
* Betacoronavirus
* COVID-19
* Comorbidity
* Coronavirus Infections
* Female
* Frail Elderly
* Geriatrics
* Humans
* Male
* Models, Statistical
* Outcome Assessment, Health Care
* Pandemics
* Pneumonia, Viral
* Prognosis
* SARS-CoV-2
* Survival Analysis
* Sweden
|keywords=* COVID-19
* aging
* comorbidity
* frailty
* geriatrics
* survival
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7427570
}}
{{medline-entry
|title=Clinical and demographic parameters predict the progression from mild cognitive impairment to dementia in elderly patients.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32918697
 
 
|keywords=* Aging
* Cox regression
* Dementia
* Follow-up
* Mild cognitive impairment
|full-text-url=https://sci-hub.do/10.1007/s40520-020-01697-8
}}
{{medline-entry
|title=Plasma Dehydroepiandrosterone Sulfate and Cardiovascular Disease Risk in Older Men and Women.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32785663
 
 
|keywords=* DHEA-S
* aging
* heart failure
* mortality
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7526732
}}
{{medline-entry
|title=High intensity interval training combined with L-citrulline supplementation: Effects on physical performance in healthy older adults.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32721549
 
 
|keywords=* Aging
* Body composition
* Exercise
* Mobility
* Nutrition
|full-text-url=https://sci-hub.do/10.1016/j.exger.2020.111036
}}
{{medline-entry
|title=Associations of blood pressure with risk of injurious falls in old age vary by functional status: A cohort study.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32738383
 
 
|keywords=* Aging
* Blood pressure
* Falls
* Injury
* Swedish National study on Aging and Care in Kungsholmen (SNAC-K)
|full-text-url=https://sci-hub.do/10.1016/j.exger.2020.111038
}}
{{medline-entry
|title=Epigenetic age acceleration and clinical outcomes in gliomas.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32692766
 
|mesh-terms=* Adult
* Aging
* DNA Methylation
* Epigenesis, Genetic
* Female
* Glioma
* Humans
* Male
* Middle Aged
* Prognosis
* Survival Analysis
 
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7373289
}}
{{medline-entry
|title=Do Stairs Inhibit Seniors Who Live on Upper Floors From Going Out?
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32666833
 
 
|keywords=* active aging
* activity monitor
* homebound
* mobility
* walk-up buildings
|full-text-url=https://sci-hub.do/10.1177/1937586720936588
}}
{{medline-entry
|title=Age-specific acute changes in carotid-femoral pulse wave velocity with head-up tilt.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32634245
 
 
|keywords=* arterial function
* arterial stiffness
* blood pressure
* early vascular aging
* pressure dependence
|full-text-url=https://sci-hub.do/10.1093/ajh/hpaa101
}}
{{medline-entry
|title=Pre-frailty status increases the risk of rehospitalization in patients after elective cardiac surgery without complication.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32531126
 
|mesh-terms=* Aged
* Cardiac Surgical Procedures
* Elective Surgical Procedures
* Female
* Frailty
* Humans
* Male
* Patient Readmission
* Postoperative Complications
* Retrospective Studies
* Risk
|keywords=* adverse events
* aging
* cardiac surgery
* frailty
* rehospitalization
|full-text-url=https://sci-hub.do/10.1111/jocs.14550
}}
{{medline-entry
|title=Comparative Performance of Creatinine-Based GFR Estimation Equations in Exceptional Longevity: The Rugao Longevity and Ageing Study.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32546991
 
|mesh-terms=* Aged, 80 and over
* Creatinine
* Female
* Glomerular Filtration Rate
* Humans
* Kidney Function Tests
* Longevity
* Male
* Mortality
* Predictive Value of Tests
* Renal Insufficiency
* Reproducibility of Results
* Risk Factors
|keywords=* equation
* exceptional longevity
* glomerular filtration rate
* kidney function
* mortality
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7266309
}}
{{medline-entry
|title=Sex-and race-specific associations of protein intake with change in muscle mass and physical function in older adults: the Health, Aging, and Body Composition (Health ABC) Study.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32520344
 
|mesh-terms=* Aged
* Aged, 80 and over
* Aging
* Biomass
* Body Composition
* Body Weight
* Dietary Proteins
* Female
* Humans
* Independent Living
* Male
* Muscle Development
* Muscle Strength
* Muscles
* Prospective Studies
* Sex Factors
|keywords=* appendicular lean body mass
* community-dwelling
* gait speed
* mobility limitation
* old age
* optimal intake
* physical performance
* spline functions
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7326591
}}
{{medline-entry
|title=Deterioration of bone microstructure by aging and menopause in Japanese healthy women: analysis by [[HR]]-pQCT.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32519249
 
|mesh-terms=* Absorptiometry, Photon
* Adult
* Aged
* Aging
* Asian Continental Ancestry Group
* Bone Density
* Bone and Bones
* Cancellous Bone
* Cortical Bone
* Female
* Finite Element Analysis
* Humans
* Japan
* Linear Models
* Menopause
* Middle Aged
* Porosity
* Tomography, X-Ray Computed
|keywords=* Bone microstructure
* Estimated bone strength
* High resolution peripheral quantitative CT (HR-pQCT)
* Japanese women
* Non-metric trabecular parameter
|full-text-url=https://sci-hub.do/10.1007/s00774-020-01115-z
}}
{{medline-entry
|title=Association between Low Protein Intake and Mortality in Patients with Type 2 Diabetes.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32492838
 
 
|keywords=* aging
* diabetes
* mortality
* nutritional support
* protein intake
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7352318
}}
{{medline-entry
|title=CAUSES, mortality rates and risk factors of death in community-dwelling Europeans aged 50 years and over: Results from the Survey of Health, Ageing and Retirement in Europe 2013-2015.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32325305
 
|mesh-terms=* Activities of Daily Living
* Aged
* Aging
* Cohort Studies
* Europe
* Humans
* Independent Living
* Male
* Middle Aged
* Mortality
* Proportional Hazards Models
* Prospective Studies
* Retirement
* Risk Factors
* Surveys and Questionnaires
|keywords=* Aging
* Comorbidity
* Depressive symptoms
* Diseases
* Mortality risk
|full-text-url=https://sci-hub.do/10.1016/j.archger.2020.104035
}}
{{medline-entry
|title=Estimation of Wave Condition Number From Pressure Waveform Alone and Its Changes With Advancing Age in Healthy Women and Men.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32328003
 
 
|keywords=* arterial wave reflection
* cardiovascular biomarker
* optimum cardiovascular function
* vascular aging
* wave condition number
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7161432
}}
{{medline-entry
|title=Extended in vitro culture of primary human mesenchymal stem cells downregulates Brca1-related genes and impairs DNA double-strand break recognition.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32333827
 
 
|keywords=*
BRCA1
 
* DNA repair
* cellular aging
* homologous recombination
* mesenchymal stem cells
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7327915
}}
{{medline-entry
|title=Effect of artificial dawn light on cardiovascular function, alertness, and balance in middle-aged and older adults.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32307533
 
 
|keywords=* aging
* alertness
* balance
* blood pressure
* heart rate
* heart rate variability
* light
* sleep inertia
|full-text-url=https://sci-hub.do/10.1093/sleep/zsaa082
}}
{{medline-entry
|title=Heart Rate Performance Curve Is Dependent on Age, Sex, and Performance.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32300582
 
 
|keywords=* aging
* heart rate deflection
* intensity prescription
* maximal heart rate
* sex differences
* ß1-receptor sensitivity
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7144539
}}
{{medline-entry
|title=Physical activity trajectories, mortality, hospitalization, and disability in the Toledo Study of Healthy Aging.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32163233
 
 
|keywords=* Adverse outcomes
* Healthy aging
* Mortality
* Older adults
* Physical activity
* Trajectories
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7432572
}}
{{medline-entry
|title=U-Shaped Association of Plasma Testosterone, and no Association of Plasma Estradiol, with Incidence of Fractures in Men.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32155267
 
 
|keywords=* estradiol
* fracture
* male aging
* osteoporosis
* sex hormone-binding globulin
* testosterone
|full-text-url=https://sci-hub.do/10.1210/clinem/dgaa115
}}
{{medline-entry
|title=Pregnancy-Related Bone Mineral and Microarchitecture Changes in Women Aged 30 to 45 Years.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32119748
 
 
|keywords=* AGING
* ANALYSIS/QUANTITATION OF BONE
* BONE QCT/μCT
* EPIDEMIOLOGY
* GENERAL POPULATION STUDIES
|full-text-url=https://sci-hub.do/10.1002/jbmr.3998
}}
{{medline-entry
|title=Analysis of the world record time for combined father and son marathon.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31917623
 
 
|keywords=* V̇o2max
* aerobic exercise
* aging
* endurance
* oxygen consumption
* running
|full-text-url=https://sci-hub.do/10.1152/japplphysiol.00819.2019
}}
{{medline-entry
|title=Age-related reductions in heart rate variability do not worsen during exposure to humid compared to dry heat: A secondary analysis.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31934605
 
 
|keywords=* Aging
* autonomic nervous system
* heat stress
* parasympathetic nervous system
* relative humidity
* sympathetic nervous system
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6949029
}}
{{medline-entry
|title=Efficacy and Safety of Dapagliflozin in the Elderly: Analysis From the DECLARE-TIMI 58 Study.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31843945
 
|mesh-terms=* Adult
* Age Factors
* Aged
* Aged, 80 and over
* Aging
* Benzhydryl Compounds
* Cardiovascular System
* Diabetes Mellitus, Type 2
* Diabetic Ketoacidosis
* Female
* Glucosides
* Humans
* Hypoglycemia
* Hypoglycemic Agents
* Incidence
* Kidney
* Male
* Middle Aged
* Sodium-Glucose Transporter 2 Inhibitors
* Survival Analysis
* Treatment Outcome
* Urinary Tract Infections
 
|full-text-url=https://sci-hub.do/10.2337/dc19-1476
}}
{{medline-entry
|title=Validity of Prediction Equations of Maximal Heart Rate in Physically Active Female Adolescents and the Role of Maturation.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31766291
 
|mesh-terms=* Adolescent
* Aging
* Body Mass Index
* Exercise
* Exercise Test
* Female
* Heart Rate
* Humans
|keywords=* cardiac rate
* exercise prescription
* exercise testing
* prediction equations
* training zones
* volleyball
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6915545
}}
{{medline-entry
|title=Base excision repair but not DNA double-strand break repair is impaired in aged human adipose-derived stem cells.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31782607
 
|mesh-terms=* Adipose Tissue
* Adult
* Aging
* DNA Breaks, Double-Stranded
* DNA End-Joining Repair
* DNA Repair
* Humans
* Middle Aged
* Recombinational DNA Repair
* Stem Cells
* Up-Regulation
* X-ray Repair Cross Complementing Protein 1
* Young Adult
|keywords=* XRCC1
* adipose-derived stem cells
* base excision repair
* genome integrity
* human aging
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6996963
}}
{{medline-entry
|title=Urban-Rural Differences in Hip Fracture Mortality: A Nationwide NOREPOS Study.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31768493
 
 
|keywords=* AGING
* EPIDEMIOLOGY
* GENERAL POPULATION STUDIES
* OSTEOPOROSIS
* STATISTICAL METHODS
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6874178
}}
{{medline-entry
|title=Malnutrition as a Strong Predictor of the Onset of Sarcopenia.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31783482
 
|mesh-terms=* Aged
* Aging
* Cohort Studies
* Female
* Humans
* Independent Living
* Male
* Malnutrition
* Proportional Hazards Models
* Prospective Studies
* Risk Factors
* Sarcopenia
|keywords=* EWGSOP2
* GLIM
* SarcoPhAge
* malnutrition
* sarcopenia
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6950107
}}
{{medline-entry
|title=Acclimation to a thermoneutral environment abolishes age-associated alterations in heart rate and heart rate variability in conscious, unrestrained mice.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31776883
 
 
|keywords=* Aging
* Cardiac autonomic modulation
* Heart rate
* Heart rate variability
* Thermoneutrality
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7031176
}}
{{medline-entry
|title=Long-term dementia risk prediction by the LIBRA score: A 30-year follow-up of the CAIDE study.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31736136
 
|mesh-terms=* Aged
* Apolipoproteins E
* Cognitive Dysfunction
* Dementia
* Female
* Follow-Up Studies
* Genetic Predisposition to Disease
* Humans
* Life Style
* Male
* Protective Factors
* Risk Assessment
* Risk Factors
|keywords=* cognitive aging
* cohort study
* dementia
* epidemiology
* lifestyle
* prevention
* risk factors
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7003764
}}
{{medline-entry
|title=Kidney function and its association to imminent, short- and long-term fracture risk-a longitudinal study in older women.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31754754
 
 
|keywords=* Aging
* Bone mineral density
* Chronic kidney disease
* Estimated glomerular filtration rate
* Fracture
* Women
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6946753
}}
{{medline-entry
|title=Oxidatively Damaged DNA/RNA and 8-Isoprostane Levels Are Associated With the Development of Type 2 Diabetes at Older Age: Results From a Large Cohort Study.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31653645
 
|mesh-terms=* Age of Onset
* Aged
* Aging
* Biomarkers
* Cohort Studies
* DNA
* DNA Damage
* Diabetes Mellitus, Type 2
* Dinoprost
* Female
* Follow-Up Studies
* Germany
* Humans
* Incidence
* Lipid Peroxidation
* Male
* Middle Aged
* Oxidation-Reduction
* Oxidative Stress
* RNA
 
|full-text-url=https://sci-hub.do/10.2337/dc19-1379
}}
{{medline-entry
|title=Associations of vigorous physical activity with all-cause, cardiovascular and cancer mortality among 64 913 adults.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31548909
 
 
|keywords=* cardio-protection
* exercise
* longevity
* non-communicable diseases
* physical activity
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6733336
}}
{{medline-entry
|title=Reduced cerebrovascular and cardioventilatory responses to intermittent hypoxia in elderly.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31557538
 
|mesh-terms=* Adult
* Aged
* Aging
* Blood Pressure
* Brain
* Cerebrovascular Circulation
* Female
* Heart Rate
* Humans
* Hypoxia
* Male
* Pulmonary Ventilation
* Ultrasonography, Doppler, Transcranial
* Young Adult
|keywords=* Aging
* Arterial oxygen saturation
* Cerebral blood flow
* Cerebral tissue oxygenation
* Heart rate
* Hypoxemia
* Ventilation
|full-text-url=https://sci-hub.do/10.1016/j.resp.2019.103306
}}
{{medline-entry
|title=Vestibulo-sympathetic reflex in patients with bilateral vestibular loss.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31513442
 
|mesh-terms=* Aging
* Bilateral Vestibulopathy
* Female
* Humans
* Male
* Middle Aged
* Reflex, Abnormal
* Sympathetic Nervous System
|keywords=* bilateral vestibular loss
* compensation
* multisensory integration
* otolithic system
* vestibulo-sympathetic reflex
|full-text-url=https://sci-hub.do/10.1152/japplphysiol.00466.2019
}}
{{medline-entry
|title=Heart rate and blood pressure in male Ts65Dn mice: a model to investigate cardiovascular responses in Down syndrome.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31496136
 
|mesh-terms=* Animals
* Autonomic Nervous System
* Blood Pressure
* Circadian Rhythm
* Down Syndrome
* Heart Rate
* Male
* Mice
* Mice, Inbred C57BL
* Vascular Stiffness
|keywords=* Aging
* arterial stiffness
* autonomic nervous system
* circadian
* pulse wave velocity
* spectral analysis
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6732568
}}
{{medline-entry
|title=Body weight at 10 years of age and change in body composition between 8 and 10 years of age were related to survival in a longitudinal study of 39 Labrador retriever dogs.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31500653
 
|mesh-terms=* Adipose Tissue
* Animals
* Body Composition
* Body Weight
* Dogs
* Longevity
* Longitudinal Studies
* Survival Analysis
|keywords=* Cohort
* Cox
* DEXA
* Dogs
* Fat mass
* Healthspan
* Lean mass
* Lean to fat ratio
* Longevity
* Sarcopenia
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6734441
}}
{{medline-entry
|title=Dietary diversity offsets the adverse mortality risk among older indigenous Taiwanese.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31464406
 
|mesh-terms=* Aged
* Aged, 80 and over
* Asian Continental Ancestry Group
* Diet
* Female
* Health Surveys
* Humans
* Indigenous Peoples
* Longevity
* Male
* Mortality
* Nutrition Surveys
* Nutritional Status
* Risk Factors
* Taiwan
 
|full-text-url=https://sci-hub.do/10.6133/apjcn.201909_28(3).0019
}}
{{medline-entry
|title=Independent and joint effects of vascular and cardiometabolic risk factor pairs for risk of all-cause dementia: a prospective population-based study.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31455442
 
|mesh-terms=* Aged
* Aged, 80 and over
* Aging
* Apolipoprotein E4
* Cognitive Dysfunction
* Dementia
* Exercise
* Female
* Heart Failure
* Heterozygote
* Humans
* Hypertension
* Male
* Pennsylvania
* Proportional Hazards Models
* Prospective Studies
* Risk Factors
* Stroke
|keywords=* Alzheimer‘s disease (AD)
* apolipoprotein E (APOE)
* cerebral vascular disease (CVD)
* dementia
* epidemiology
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6948010
}}
{{medline-entry
|title=Work Ability and Job Survival: Four-Year Follow-Up.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31466415
 
|mesh-terms=* Adult
* Brazil
* Employment
* Female
* Follow-Up Studies
* Hospitals
* Humans
* Male
* Proportional Hazards Models
* Work Capacity Evaluation
|keywords=* aging
* healthcare worker
* life course
* longitudinal studies
* prolonged work career
* work ability
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6747402
}}
{{medline-entry
|title=Predictivity of bioimpedance phase angle for incident disability in older adults.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31436391
 
 
|keywords=* Aging
* Body composition
* Cellular health
* Muscle mass
* Nutrition
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7015240
}}
==HRAS==
 
{{medline-entry
|title=How do combinations of unhealthy behaviors relate to attitudinal factors and subjective health among the adult population in the Netherlands?
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32245376
 
|mesh-terms=* Adult
* Alcohol Drinking
* Attitude to Health
* Cluster Analysis
* Diagnostic Self Evaluation
* Diet, Healthy
* Exercise
* Female
* Health Risk Behaviors
* Humans
* Life Expectancy
* Life Style
* Logistic Models
* Male
* Middle Aged
* Netherlands
* Prevalence
* Sedentary Behavior
* Smoking
* Surveys and Questionnaires
* Young Adult
|keywords=* Clustering risk attitude
* Health behaviours
* Subjective health
* Time orientation
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7126128
}}
{{medline-entry
|title=Elucidating Proteoform Dynamics Underlying the Senescence Associated Secretory Phenotype.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31940439
 
 
|keywords=* proteoform
* quantitative proteomics
* secretome
* senescence
* top-down proteomics
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7032038
}}
==HS2ST1==
 
{{medline-entry
|title=Whole Genome Analysis of the Red-Crowned Crane Provides Insight into Avian Longevity.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31940721
 
|mesh-terms=* Animals
* Avian Proteins
* Birds
* Endangered Species
* Immunity
* Longevity
* Polymorphism, Genetic
* Species Specificity
* Transcriptome
* Whole Genome Sequencing
|keywords=* genome
* longevity
* red-crowned crane
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6999708
}}
==HSF1==
 
{{medline-entry
|title=A Mitochondrial Stress-Specific Form of [[HSF1]] Protects against Age-Related Proteostasis Collapse.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32735771
 
 
|keywords=* HSF1
* PP2A
* aging
* mitochondria
* molecular chaperones
* protein aggregation
* proteostasis
* stress responses
|full-text-url=https://sci-hub.do/10.1016/j.devcel.2020.06.038
}}
{{medline-entry
|title=Heat shock factor 1-mediated transcription activation of Omi/HtrA2 induces myocardial mitochondrial apoptosis in the aging heart.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31627188
 
|mesh-terms=* Aging
* Animals
* Apoptosis
* Heat Shock Transcription Factors
* High-Temperature Requirement A Serine Peptidase 2
* Male
* Mice
* Mice, Inbred C57BL
* Mitochondria, Heart
* Myocytes, Cardiac
* NIH 3T3 Cells
* Transcriptional Activation
* Up-Regulation
|keywords=* Omi/HtrA2
* age-related pathology
* cardiovascular
* mitochondria
* transcriptional regulation
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6834417
}}
{{medline-entry
|title=Multifactorial Attenuation of the Murine Heat Shock Response With Age.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31612204
 
 
|keywords=* Aging
* HSF1
* Stress
|full-text-url=https://sci-hub.do/10.1093/gerona/glz204
}}
==HSPA1A==
 
{{medline-entry
|title=Vitamin D3 treatment regulates apoptosis, antioxidant defense system, and DNA integrity in the epididymal sperm of an aged rat model.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31566824
 
|mesh-terms=* Aging
* Animals
* Antioxidants
* Apoptosis
* Cholecalciferol
* Epididymis
* Male
* Rats
* Rats, Wistar
* Spermatozoa
|keywords=* aging
* apoptosis
* oxidative stress
* sperm
|full-text-url=https://sci-hub.do/10.1002/mrd.23280
}}
==HSPA1L==
 
{{medline-entry
|title=Melatonin suppresses senescence-derived mitochondrial dysfunction in mesenchymal stem cells via the [[HSPA1L]]-mitophagy pathway.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31965731
 
 
|keywords=* HSPA1L
* melatonin
* mesenchymal stem cells
* mitochondria
* mitophagy
* replicative senescence
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7059143
}}
==HTT==
 
{{medline-entry
|title=Biological Aging and the Cellular Pathogenesis of Huntington's Disease.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32417788
 
 
|keywords=* Biological aging
* DNA damage
* Huntington’s disease
* cellular aging
* microsatellite instability
* neurodegeneration
* oxidative stress
* proteostasis
* telomere
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7369111
}}
==ICE1==
 
{{medline-entry
|title=ATBS1-INTERACTING FACTOR 2 negatively regulates dark- and brassinosteroid-induced leaf senescence through interactions with INDUCER OF CBF EXPRESSION 1.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31783407
 
 
|keywords=* ATBS1-INTERACTING FACTOR 2 (AIF2)
* Arabidopsis
* C-REPEAT BINDING FACTOR (CBF)
* INDUCER OF CBF EXPRESSION 1 (ICE1)
* PHYTOCHROME-INTERACTING FACTORS (PIFs)
* basic helix–loop–helix (bHLH)
* brassinosteroid (BR)
* leaf senescence
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7031079
}}
==IDE==
 
{{medline-entry
|title=Dendrobium nobile Lindl. Alkaloids Ameliorate Cognitive Dysfunction in Senescence Accelerated SAMP8 Mice by Decreasing Amyloid-β Aggregation and Enhancing Autophagy Activity.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32538851
 
 
|keywords=* Aging
* Dendrobium nobile Lindl. alkaloid (DNLA)
* amyloid-β
* autophagy
* metformin
* senescence accelerated mouse prone 8 (SAMP8)
|full-text-url=https://sci-hub.do/10.3233/JAD-200308
}}
==IDH2==
 
{{medline-entry
|title=Reactive oxygen species-mediated senescence is accelerated by inhibiting Cdk2 in Idh2-deficient conditions.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31503005
 
|mesh-terms=* Animals
* Cellular Senescence
* Cyclin-Dependent Kinase 2
* Cyclin-Dependent Kinase Inhibitor p21
* Embryo, Mammalian
* Fibroblasts
* Isocitrate Dehydrogenase
* Mice
* Mice, Knockout
* NIH 3T3 Cells
* Reactive Oxygen Species
|keywords=* cell cycle
* cyclin-dependent kinase 2 (Cdk2)
* isocitrate dehydrogenase 2 (IDH2)
* reactive oxygen species (ROS)
* senescence
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6756887
}}
==IDS==
 
{{medline-entry
|title=Effect of immediate dentine sealing on the aging and fracture strength of lithium disilicate inlays and overlays.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32957211
 
 
|keywords=* Aging
* Ceramic
* Fracture strength
* Immediate dentin sealing
* Inlay
* Overlay
|full-text-url=https://sci-hub.do/10.1016/j.jmbbm.2020.103906
}}
==IFI27==
 
{{medline-entry
|title=Ultraviolet B irradiation-induced keratinocyte senescence and impaired development of 3D epidermal reconstruct.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/33151171
 
 
|keywords=* epidermis
* keratinocytes
* reactive oxygen species
* senescence
* skin aging
* ultraviolet radiation
|full-text-url=https://sci-hub.do/10.2478/acph-2021-0011
}}
==IGF1==
 
{{medline-entry
|title=Genetic differences and longevity-related phenotypes influence lifespan and lifespan variation in a sex-specific manner in mice.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/33105070
 
 
|keywords=* IGF1
* antagonistic gene
* female sexual maturation
* lifespan variation
* maximum lifespan
* sex difference in lifespan
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7681063
}}
{{medline-entry
|title=17α-estradiol modulates [[IGF1]] and hepatic gene expression in a sex-specific manner.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32857104
 
 
|keywords=* 17α-estradiol
* aging
* growth hormone
* insulin
* insulin-like growth factor-1
* liver
|full-text-url=https://sci-hub.do/10.1093/gerona/glaa215
}}
{{medline-entry
|title=Pan-mammalian analysis of molecular constraints underlying extended lifespan.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32043462
 
 
|keywords=* RERconverge
* computational biology
* evolution
* genetics
* genomics
* longevity
* mammals
* phylogenomics
* systems biology
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7012612
}}
{{medline-entry
|title=17α-Estradiol promotes ovarian aging in growth hormone receptor knockout mice, but not wild-type littermates.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31698046
 
 
|keywords=* Follicles
* Ovarian aging
* Ovarian reserve
* Reproductive lifespan
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6911620
}}
==IGF1R==
 
{{medline-entry
|title=Comparison of mitochondrial transplantation by using a stamp-type multineedle injector and platelet-rich plasma therapy for hair aging in naturally aging mice.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32707439
 
 
|keywords=* Aging mice
* Hair growth
* Mitochondrial transplantation
* Pep-1
* Platelet-rich plasma
|full-text-url=https://sci-hub.do/10.1016/j.biopha.2020.110520
}}
==IGFBP1==
 
{{medline-entry
|title=Role of [[IGFBP1]] in the senescence of vascular endothelial cells and severity of aging‑related coronary atherosclerosis.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31545483
 
|mesh-terms=* Adult
* Aged
* Aged, 80 and over
* Aging
* Atherosclerosis
* Cells, Cultured
* Cellular Senescence
* Coronary Artery Disease
* Coronary Vessels
* Down-Regulation
* Endothelial Cells
* Female
* Humans
* Insulin-Like Growth Factor Binding Protein 1
* Jagged-1 Protein
* Male
* Middle Aged
* Signal Transduction
* Up-Regulation
 
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6777673
}}
==IGFBP2==
 
{{medline-entry
|title=Intracellular Insulin-like growth factor binding protein 2 ([[IGFBP2]]) contributes to the senescence of keratinocytes in psoriasis by stabilizing cytoplasmic p21.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32302288
 
 
|keywords=* insulin-like growth factor binding protein 2
* keratinocytes
* p21CIP1/WAF1
* psoriasis
* senescence
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7202509
}}
==IGFBP3==
 
{{medline-entry
|title=Cellular and Molecular Biomarkers Indicate Premature Aging in Pseudoxanthoma Elasticum Patients.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32489700
 
 
|keywords=* CCL11
* GDF11
* IGF1
* IGFBP
* aging
* pseudoxanthoma elasticum
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7220280
}}
{{medline-entry
|title=Paracrine senescence of human endometrial mesenchymal stem cells: a role for the insulin-like growth factor binding protein 3.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31951594
 
 
|keywords=* IGFBP3
* endocytosis
* endometrial stem cells
* paracrine senescence
* secretome
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7053595
}}
==IGFBP4==
 
{{medline-entry
|title=Quantitative iTRAQ-based proteomic analysis of differentially expressed proteins in aging in human and monkey.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31601169
 
|mesh-terms=* Adult
* Aged
* Aged, 80 and over
* Aging
* Animals
* Cognition
* Female
* Gene Expression Regulation
* Gene Regulatory Networks
* Haplorhini
* Humans
* Insulin-Like Growth Factor Binding Protein 4
* Male
* Mice
* Proteomics
|keywords=* Cognitive dysfunction
* IGFBP4
* Plasma
* Quantitative proteomics
* iTRAQ
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6788010
}}
==IGFBP7==
 
{{medline-entry
|title=Reprogramming of human fibroblasts into osteoblasts by insulin-like growth factor-binding protein 7.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31904196
 
 
|keywords=* IGFBP7
* IL-6
* human fibroblast
* osteoblast
* reprogramming
* senescence
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7031646
}}
==IHH==
 
{{medline-entry
|title=Indian Hedgehog regulates senescence in bone marrow-derived mesenchymal stem cell through modulation of ROS/mTOR/4EBP1, p70S6K1/2 pathway.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32235006
 
 
|keywords=* Indian hedgehog
* aging
* differentiation
* mammalian target of rapamycin
* mesenchymal stem cell
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7185126
}}
==IL10==
 
{{medline-entry
|title=The beneficial effect of physical exercise on inflammatory makers in older individuals.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32504508
 
 
|keywords=* IL-6 expression
* Inflammatory markers
* aerobic exercise
* aging
* plasma IL-6 levels
* resistance training
|full-text-url=https://sci-hub.do/10.2174/1871530320666200606225357
}}
{{medline-entry
|title=Astrocyte senescence may drive alterations in GFAPα, CDKN2A p14 , and TAU3 transcript expression and contribute to cognitive decline.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31654269
 
|mesh-terms=* Aged
* Alternative Splicing
* Astrocytes
* Cells, Cultured
* Cellular Senescence
* Cognitive Dysfunction
* Cytokines
* Gene Expression
* Glial Fibrillary Acidic Protein
* Humans
* Matrix Metalloproteinases
* Transcription, Genetic
* Tumor Suppressor Protein p14ARF
* tau Proteins
|keywords=* Alternative splicing
* Gene expression
* Neurodegenerative disease
* Senescence
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6885035
}}
{{medline-entry
|title=Dietary Spray-Dried Porcine Plasma Prevents Cognitive Decline in Senescent Mice and Reduces Neuroinflammation and Oxidative Stress.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31562503
 
|mesh-terms=* Animals
* Cognition Disorders
* Encephalitis
* Male
* Mice
* Oxidative Stress
* Plasma
* Swine
|keywords=* aging
* cognitive decline
* dietary supplementation
* neuroinflammation
* spray-dried animal plasma
|full-text-url=https://sci-hub.do/10.1093/jn/nxz239
}}
==IL15==
 
{{medline-entry
|title=Moderate physical activity associated with a higher naïve/memory T-cell ratio in healthy old individuals: potential role of [[IL15]].
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32221610
 
 
|keywords=* T cells
* ageing
* immune senescence
* older people
* physical activity
|full-text-url=https://sci-hub.do/10.1093/ageing/afaa035
}}
==IL1A==
 
{{medline-entry
|title=IL1B triggers inflammatory cytokine production in bovine oviduct epithelial cells and induces neutrophil accumulation via CCL2.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/33099841
 
 
|keywords=* CCL2
* cellular senescence
* inflammaging
* senescence-associated secretory phenotype
|full-text-url=https://sci-hub.do/10.1111/aji.13365
}}
==IL2==
 
{{medline-entry
|title=Impact of Aging on the Phenotype of Invariant Natural Killer T Cells in Mouse Thymus.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/33193368
 
 
|keywords=* IL2
* aging
* invariant natural killer T cells
* thymus
* transcriptome
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7662090
}}
==IL6==
 
{{medline-entry
|title=Basic immunology may lead to translational therapeutic rationale: SARS-CoV-2 and rheumatic diseases.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32645207
 
|mesh-terms=* Adaptive Immunity
* Aged
* Antirheumatic Agents
* COVID-19
* Comorbidity
* Coronavirus Infections
* Disease Outbreaks
* Female
* Humans
* Hydroxychloroquine
* Immunity, Innate
* Immunologic Factors
* Immunosuppressive Agents
* Italy
* Male
* Middle Aged
* Pandemics
* Pneumonia, Viral
* Rheumatic Diseases
* Risk Assessment
* Severe Acute Respiratory Syndrome
|keywords=* COVID-19
* SARS-CoV-2
* geriatrics
* pathophysiology
* pediatrics
* rheumatology
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7404583
}}
{{medline-entry
|title=ATM-deficient neural precursors develop senescence phenotype with disturbances in autophagy.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32621937
 
 
|keywords=* ATM
* Ataxia-telangiectasia
* Autophagy
* Mitophagy
* Neural progenitors
* Oxidative stress
* Senescence
* hiPSCs
|full-text-url=https://sci-hub.do/10.1016/j.mad.2020.111296
}}
{{medline-entry
|title=The microRNA-34a-Induced Senescence-Associated Secretory Phenotype (SASP) Favors Vascular Smooth Muscle Cells Calcification.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32585876
 
 
|keywords=* IL6
* SASP
* VSMCs
* inflammaging
* senescence
* vascular calcification
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7352675
}}
{{medline-entry
|title=Impact of Influenza on Pneumococcal Vaccine Effectiveness during [i]Streptococcus pneumoniae[/i] Infection in Aged Murine Lung.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32545261
 
 
|keywords=* Streptococcus pneumoniae
* aging
* influenza
* vaccine effectiveness
* viral immune imprinting
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7349919
}}
{{medline-entry
|title=Patterns of multi-domain cognitive aging in participants of the Long Life Family Study.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32514870
 
 
|keywords=* Aging
* Biomarker
* Cognition
* Neuropsychology
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7525612
}}
{{medline-entry
|title=Cholest-4,6-Dien-3-One Promote Epithelial-To-Mesenchymal Transition (EMT) in Biliary Tree Stem/Progenitor Cell Cultures In Vitro.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31731674
 
|mesh-terms=* Biliary Tract
* Cell Differentiation
* Cell Proliferation
* Cells, Cultured
* Cellular Senescence
* Cholestenones
* Epithelial-Mesenchymal Transition
* Histone Deacetylase 6
* Humans
* Interleukin-6
* Signal Transduction
* Stem Cells
* Tissue Donors
|keywords=* BMP pathway
* SHH pathway
* biliary tree stem/progenitor cells (BTSCs)
* epithelial-to-mesenchymal transition (EMT)
* primary sclerosing cholangitis (PSC)
* senescence
* telomerase
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6912632
}}
{{medline-entry
|title=Single xenotransplant of rat brown adipose tissue prolonged the ovarian lifespan of aging mice by improving follicle survival.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31389140
 
|mesh-terms=* Adipose Tissue, Brown
* Animals
* Cellular Senescence
* Female
* Longevity
* Male
* Mice
* Ovarian Follicle
* Ovary
* Rats
* Rats, Sprague-Dawley
* Transplantation, Heterologous
|keywords=* aging
* brown adipose tissue (BAT)
* lifespan
* mice
* ovary
* rat
* xenotransplant
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6826128
}}
==ILDR1==
 
{{medline-entry
|title=Genome-wide association meta-analysis identifies five novel loci for age-related hearing impairment.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31645637
 
|mesh-terms=* Aging
* Animals
* Auditory Pathways
* Female
* Gene Expression Regulation
* Genetic Loci
* Genetic Predisposition to Disease
* Genome-Wide Association Study
* Hearing Loss
* Humans
* Male
* Mice
* Middle Aged
* Molecular Sequence Annotation
* Phenotype
* Reproducibility of Results
 
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6811684
}}
==IMPACT==
 
{{medline-entry
|title=Load-dependent modulation of alpha oscillations during working memory encoding and retention in young and older adults.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/33141460
 
 
|keywords=* EEG
* alpha oscillations
* cognitive aging
* working memory
|full-text-url=https://sci-hub.do/10.1111/psyp.13719
}}
{{medline-entry
|title=Using Video Telehealth to Deliver Patient-Centered Collaborative Care: The G-[[IMPACT]] Pilot.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32228299
 
 
|keywords=* Telehealth
* aging
* care coordination
* home care
* interdisciplinary
* medicine
* older adult
* video
|full-text-url=https://sci-hub.do/10.1080/07317115.2020.1738000
}}
{{medline-entry
|title=AGING, HEART RATE VARIABILITY AND METABOLIC [[IMPACT]] OF OBESITY.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31969754
 
|mesh-terms=* Aging
* Autonomic Nervous System
* Autonomic Nervous System Diseases
* Female
* Heart Rate
* Humans
* Male
* Metabolic Diseases
* Metabolism
* Middle Aged
* Obesity
|keywords=* Aging
* Autonomic nervous system
* Heart rate
* Obesity, metabolically benign
* Parasympathetic nervous system
* Sympathetic nervous system
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6971797
}}
==INS==
 
{{medline-entry
|title=Melatonin protects [[INS]]-1 pancreatic β-cells from apoptosis and senescence induced by glucotoxicity and glucolipotoxicity.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32673151
 
 
|keywords=* Melatonin
* Senescence
* glucolipotoxicity
* glucotoxicity
* pancreatic β-cell
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7527021
}}
{{medline-entry
|title=Nicotine triggers islet β cell senescence to facilitate the progression of type 2 diabetes.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32473187
 
|mesh-terms=* Animals
* Blotting, Western
* Calcium
* Cellular Senescence
* Diabetes Mellitus, Type 2
* Disease Progression
* Dose-Response Relationship, Drug
* Enzyme-Linked Immunosorbent Assay
* Glucose
* Insulin-Secreting Cells
* Male
* Mice
* Mice, Inbred C57BL
* Nicotine
* Reactive Oxygen Species
* Real-Time Polymerase Chain Reaction
* beta-Galactosidase
|keywords=* ROS
* islet β cells
* nicotine
* senescence
* type 2 diabetes
|full-text-url=https://sci-hub.do/10.1016/j.tox.2020.152502
}}
==INSL3==
 
{{medline-entry
|title=Effect of Thyroxine Replacement on Leydig Cell and Sertoli Cell Function in Men with Hypothyroidism.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/33083267
 
 
|keywords=* Androgen deficiency in aging male
* arizona sexual experience scale
* hypothyroidism
* inhibin B
* insulin-like factor 3
* semen analysis
* sperm motility
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7539029
}}
==IP6K1==
 
{{medline-entry
|title=The Role of the IGF-1 Signaling Cascade in Muscle Protein Synthesis and Anabolic Resistance in Aging Skeletal Muscle.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31552262
 
 
|keywords=* Akt
* IP6K1
* aging
* anabolic resistance
* mTOR
* protein
* resistance exercise
* sarcopenia
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6746962
}}
==IQGAP1==
 
{{medline-entry
|title=[[IQGAP1]]-dysfunction leads to induction of senescence in human vascular smooth muscle cells.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32592713
 
 
|keywords=* Cellular bridges (CBs)
* IQGAP1
* Intercellular communication
* Senescence
* Tunneling nanotubes (TNTs)
* Vascular smooth muscle cells (VSMCs)
|full-text-url=https://sci-hub.do/10.1016/j.mad.2020.111295
}}
{{medline-entry
|title=Hyaluronan-binding protein 1 (HABP1) overexpression triggers induction of senescence in fibroblasts cells.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32068317
 
 
|keywords=* F-HABP07
* HABP1
* IQGAP1
* senescence
|full-text-url=https://sci-hub.do/10.1002/cbin.11326
}}
==IRF8==
 
{{medline-entry
|title=[[IRF8]] induces senescence of lung cancer cells to exert its tumor suppressive function.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31594449
 
|mesh-terms=* A549 Cells
* Animals
* Carcinogenesis
* Carcinoma, Non-Small-Cell Lung
* Cell Movement
* Cell Proliferation
* Cellular Senescence
* Gene Expression Regulation, Neoplastic
* Heterografts
* Humans
* Interferon Regulatory Factors
* Mice
* Prognosis
* Signal Transduction
* Tumor Suppressor Proteins
|keywords=* IRF8
* NSCLC
* cell cycle arrest
* cell senescence
* tumor suppresser gene
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6927690
}}
==IRS1==
 
{{medline-entry
|title=MicroRNA-34a causes ceramide accumulation and effects insulin signaling pathway by targeting ceramide kinase (CERK) in aging skeletal muscle.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32056304
 
 
|keywords=* CERK
* aging muscle
* insulin signaling pathway
* miR-34a
|full-text-url=https://sci-hub.do/10.1002/jcb.29312
}}
{{medline-entry
|title=Longevity in response to lowered insulin signaling requires glycine N-methyltransferase-dependent spermidine production.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31721422
 
 
|keywords=* IGF
* aging
* autophagy
* insulin
* lifespan
* metabolism
* polyamine
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6974722
}}
{{medline-entry
|title=Serine Phosphorylation of [[IRS1]] Correlates with Aβ-Unrelated Memory Deficits and Elevation in Aβ Level Prior to the Onset of Memory Decline in AD.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31426549
 
|mesh-terms=* Aging
* Alzheimer Disease
* Amyloid beta-Peptides
* Amyloid beta-Protein Precursor
* Animals
* Brain
* Diabetes Mellitus, Type 2
* Humans
* Insulin
* Insulin Receptor Substrate Proteins
* Male
* Memory
* Memory Disorders
* Mice, Inbred C57BL
* Mice, Transgenic
* Phosphorylation
* Serine
* Signal Transduction
|keywords=* AMPK
* Alzheimer’s disease
* Aβ
* IRS1
* aging
* diabetes
* energy depletion
* hippocampus
* memory decline
* serine phosphorylation
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6723493
}}
==IRS2==
 
{{medline-entry
|title=Effects of Heshouwuyin on gene expression of the insulin/IGF signalling pathway in rat testis and spermatogenic cells.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/33264567
 
 
|keywords=* IGF1
* IGFBP3
* INSR
* IRS1
* IRS2
* Male reproduction
* senescence
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7717869
}}
==ITGA3==
 
{{medline-entry
|title=A transcriptomic analysis of serial-cultured, tonsil-derived mesenchymal stem cells reveals decreased integrin α3 protein as a potential biomarker of senescent cells.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32807231
 
 
|keywords=* AKT
* Culture-aged
* ECM-receptor protein
* Integrin α3
* Senescence
* Serial passaging
* Tonsil-derived mesenchymal stem cells
* Transcriptome
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7430027
}}
==ITGA5==
 
{{medline-entry
|title=Kaempferol alleviates the reduction of developmental competence during aging of porcine oocytes.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31486245
 
|mesh-terms=* Animals
* Blastocyst
* Cellular Senescence
* Embryo Culture Techniques
* Embryo, Mammalian
* Embryonic Development
* Female
* Integrins
* Kaempferols
* Mitochondria
* Nanog Homeobox Protein
* Octamer Transcription Factor-3
* Oocytes
* Oxidative Stress
* RNA, Messenger
* Reactive Oxygen Species
* Swine
|keywords=* embryonic development
* kaempferol
* oocyte aging
* porcine
|full-text-url=https://sci-hub.do/10.1111/asj.13280
}}
==ITGAM==
 
{{medline-entry
|title=Comparative Analysis of Gene Expression Patterns for Oral Epithelium-Related Functions with Aging.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31732940
 
|mesh-terms=* Aging
* Animals
* Disease Models, Animal
* Epithelial Cells
* Gingiva
* Macaca mulatta
* Oligonucleotide Array Sequence Analysis
* Transcriptome
 
|full-text-url=https://sci-hub.do/10.1007/978-3-030-28524-1_11
}}
==IVD==
 
{{medline-entry
|title=MicroRNAs in Intervertebral Disc Degeneration, Apoptosis, Inflammation, and Mechanobiology.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32443722
 
 
|keywords=* ECM
* MMP
* annulus fibrosus
* cartilaginous endplate
* degenerative disc disease
* miRNA
* nucleus pulposus
* senescence
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7279351
}}
{{medline-entry
|title=A step-by-step protocol for isolation of murine nucleus pulposus cells.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31891122
 
 
|keywords=* aging
* gene expression
* intervertebral disc degeneration
* nucleus pulposus
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6920701
}}
{{medline-entry
|title=Caspase-3 knockout inhibits intervertebral disc degeneration related to injury but accelerates degeneration related to aging.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31852919
 
|mesh-terms=* Aging
* Animals
* Annulus Fibrosus
* Apoptosis
* Biomarkers
* Carcinogenesis
* Caspase 3
* Cell Count
* Extracellular Matrix
* Intervertebral Disc
* Intervertebral Disc Degeneration
* Mice, Inbred C57BL
* Mice, Knockout
* Nucleus Pulposus
* Up-Regulation
 
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6920379
}}
{{medline-entry
|title=Finite element and deformation analyses predict pattern of bone failure in loaded zebrafish spines.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31690186
 
|mesh-terms=* Aging
* Animals
* Back Pain
* Disease Models, Animal
* Finite Element Analysis
* Humans
* Intervertebral Disc
* Movement
* Weight-Bearing
* Zebrafish
|keywords=* deformation
* finite element
* geometric morphometrics
* mechanics
* spine
* zebrafish
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6893493
}}
{{medline-entry
|title=Improvement in determining the risk of damage to the human lumbar functional spinal unit considering age, height, weight and sex using a combination of FEM and RSM.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31473842
 
|mesh-terms=* Adult
* Age Factors
* Aging
* Analysis of Variance
* Biomechanical Phenomena
* Body Height
* Body Mass Index
* Body Weight
* Cortical Bone
* Female
* Finite Element Analysis
* Humans
* Imaging, Three-Dimensional
* Intervertebral Disc
* Lumbar Vertebrae
* Male
* Models, Biological
* Range of Motion, Articular
* Risk Factors
* Sex Characteristics
|keywords=* Age
* Biomechanics
* Body mass index (BMI)
* Finite element method (FEM)
* Functional spinal unit (FSU)
* Height
* Response surface method (RSM)
* Sex
* Weight
|full-text-url=https://sci-hub.do/10.1007/s10237-019-01215-4
}}
{{medline-entry
|title=In vivo contrast-enhanced microCT for the monitoring of mouse thoracic, lumbar, and coccygeal intervertebral discs.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31463468
 
 
|keywords=* Contrast‐enhanced microCT
* aging
* intervertebral disc
* mouse model
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6686789
}}
==JAK1==
 
{{medline-entry
|title=Irradiation-induced senescence of bone marrow mesenchymal stem cells aggravates osteogenic differentiation dysfunction via paracrine signaling.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32233952
 
|mesh-terms=* Bone Resorption
* Cell Cycle Checkpoints
* Cell Differentiation
* Cell Proliferation
* Cellular Senescence
* DNA Damage
* Gene Expression Regulation, Developmental
* Histones
* Humans
* Janus Kinase 1
* Mesenchymal Stem Cells
* Mitochondria
* Osteogenesis
* Paracrine Communication
* Radiation
* Reactive Oxygen Species
* STAT3 Transcription Factor
* Signal Transduction
|keywords=* SASP
* bone marrow mesenchymal stem cells
* cellular senescence
* irradiation
* osteogenic differentiation
|full-text-url=https://sci-hub.do/10.1152/ajpcell.00520.2019
}}
{{medline-entry
|title=The Upregulation of Toll-Like Receptor 3 via Autocrine IFN-β Signaling Drives the Senescence of Human Umbilical Cord Blood-Derived Mesenchymal Stem Cells Through [[JAK1]].
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31396213
 
|mesh-terms=* Autocrine Communication
* Cellular Senescence
* Fetal Blood
* Humans
* Interleukin-6
* Janus Kinase 1
* Mesenchymal Stem Cells
* Toll-Like Receptor 3
* Up-Regulation
|keywords=* Janus kinase 1 (JAK1)
* Toll-like receptor 3 (TLR3)
* interferon-β (IFN-β)
* mesenchymal stromal cell (MSC)
* senescence
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6665952
}}
==JAK2==
 
{{medline-entry
|title=Senescence in Monocytes Facilitates Dengue Virus Infection by Increasing Infectivity.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32850477
 
 
|keywords=* DC-SIGN
* IL-10
* dengue virus
* monocytes
* senescence
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7399640
}}
{{medline-entry
|title=Quercetin Directly Targets [[JAK2]] and PKCδ and Prevents UV-Induced Photoaging in Human Skin.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31652815
 
|mesh-terms=* Antioxidants
* Cell Line
* Cells, Cultured
* Cyclooxygenase 2
* Humans
* Janus Kinase 2
* MAP Kinase Signaling System
* Matrix Metalloproteinase 1
* NF-kappa B
* Protein Kinase C-delta
* Quercetin
* STAT3 Transcription Factor
* Skin
* Skin Aging
* Transcription Factor AP-1
* Ultraviolet Rays
|keywords=* JAK2
* PKC-delta
* quercetin
* skin aging
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6862686
}}
{{medline-entry
|title=[Red blood cell lifespan detected by endogenous carbon monoxide breath test in patients with polycythemia vera].
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31594177
 
|mesh-terms=* Adult
* Aged
* Aged, 80 and over
* Breath Tests
* Carbon Monoxide
* Case-Control Studies
* Erythrocyte Count
* Erythrocytes
* Female
* Humans
* Janus Kinase 2
* Longevity
* Male
* Middle Aged
* Polycythemia Vera
|keywords=* Carbon monoxide breath test
* Polycythemia vera
* Red blood cell lifespan
|full-text-url=https://sci-hub.do/10.3760/cma.j.issn.0578-1426.2019.10.010
}}
{{medline-entry
|title=Roles of [[JAK2]] in Aging, Inflammation, Hematopoiesis and Malignant Transformation.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31398915
 
|mesh-terms=* Aging
* Animals
* Hematopoiesis
* Humans
* Inflammation
* Janus Kinase 2
* Mice
* Myeloproliferative Disorders
* Neoplasms
|keywords=* JAK2
* Janus-kinase
* aging
* clonal hematopoiesis (CHIP), myeloproliferative neoplasia (MPN)
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6721738
}}
==JUN==
 
{{medline-entry
|title=Age-Onset Phosphorylation of a Minor Actin Variant Promotes Intestinal Barrier Dysfunction.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31794717
 
|mesh-terms=* Actin Cytoskeleton
* Actins
* Aging
* Animals
* Binding Sites
* Caenorhabditis elegans
* Caenorhabditis elegans Proteins
* Intercellular Junctions
* Intestinal Mucosa
* JNK Mitogen-Activated Protein Kinases
* Phosphorylation
* Protein Phosphatase 1
* Transcription Factors
* Troponin
|keywords=* HSF-1
* actin
* aging
* barrier
* intestine
* junctions
* kinase
* pathogenesis
* phosphorylation
* stress
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6897307
}}
==JUNB==
 
{{medline-entry
|title=Promotion of cellular senescence by THG-1/TSC22D4 knockout through activation of [[JUNB]].
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31806366
 
|mesh-terms=* Cell Line, Tumor
* Cell Proliferation
* Cellular Senescence
* Cyclin-Dependent Kinase Inhibitor p21
* Gene Expression Regulation, Neoplastic
* Gene Knockout Techniques
* HEK293 Cells
* Humans
* Transcription Factors
* Transcription, Genetic
* Up-Regulation
|keywords=* Cellular senescence
* JUNB
* P21(CDKN1A)
* THG-1(TSC22D4)
|full-text-url=https://sci-hub.do/10.1016/j.bbrc.2019.11.145
}}
==KAT6B==
 
{{medline-entry
|title=Aging-associated decrease in the histone acetyltransferase [[KAT6B]] is linked to altered hematopoietic stem cell differentiation.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32014431
 
|mesh-terms=* Aging
* Animals
* Cell Differentiation
* Epigenesis, Genetic
* Erythroid Cells
* Gene Expression Profiling
* Gene Expression Regulation, Enzymologic
* Gene Knockout Techniques
* Histone Acetyltransferases
* Male
* Mice
* Mice, Transgenic
* Myeloid Progenitor Cells
* Transcriptome
 
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7179256
}}
==KCNK2==
 
{{medline-entry
|title=Brain age prediction using deep learning uncovers associated sequence variants.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31776335
 
|mesh-terms=* Adolescent
* Adult
* Aged
* Aged, 80 and over
* Aging
* Brain
* Databases, Factual
* Deep Learning
* Genome-Wide Association Study
* Humans
* Iceland
* Magnetic Resonance Imaging
* Middle Aged
* Neural Networks, Computer
* Neuropsychological Tests
* Polymorphism, Single Nucleotide
* United Kingdom
* Young Adult
 
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6881321
}}
==KCNQ4==
 
{{medline-entry
|title=Guanylyl Cyclase A/cGMP Signaling Slows Hidden, Age- and Acoustic Trauma-Induced Hearing Loss.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32327991
 
 
|keywords=* KCNQ4
* PARP-1
* aging
* cGMP
* guanylyl cyclase A
* hidden hearing loss
* inner ear
* otoprotection
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7160671
}}
==KCTD12==
 
{{medline-entry
|title=The association between poverty and gene expression within peripheral blood mononuclear cells in a diverse Baltimore City cohort.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32970748
 
|mesh-terms=* Adult
* Demography
* Female
* Gene Expression Profiling
* Humans
* Longevity
* Male
* Metabolic Networks and Pathways
* Middle Aged
* Monocytes
* Poverty
* Transcriptome
* Urban Population
 
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7514036
}}
==KDM2A==
 
{{medline-entry
|title=SIRT6 mono-ADP ribosylates [[KDM2A]] to locally increase H3K36me2 at DNA damage sites to inhibit transcription and promote repair.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32584788
 
 
|keywords=* DNA repair
* SIRT6
* genome stability
* longevity
* transcription
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7343504
}}
==KDM2B==
 
{{medline-entry
|title=Identification of Structural Elements of the Lysine Specific Demethylase 2B CxxC Domain Associated with Replicative Senescence Bypass in Primary Mouse Cells.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32270414
 
 
|keywords=* Lysine demethylase
* Non-methylated CpG
* Oncogene
* Polycomb repressive complex
* Replicative senescence
* Zn-finger
|full-text-url=https://sci-hub.do/10.1007/s10930-020-09895-z
}}
==KDM3A==
 
{{medline-entry
|title=[[KDM3A]] and KDM4C Regulate Mesenchymal Stromal Cell Senescence and Bone Aging via Condensin-mediated Heterochromatin Reorganization.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31704649
 
 
|keywords=* Cell Biology
* DNA damage
* Molecular Mechanism of Gene Regulation
* Stem Cells Research
* bone aging
* condensin
* epigenetic regulation
* histone demethylase
* mesenchymal stromal cells
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6888768
}}
==KEAP1==
 
{{medline-entry
|title=NRF2 pathway activation by [[KEAP1]] inhibition attenuates the manifestation of aging phenotypes in salivary glands.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32590331
 
 
|keywords=* Aging
* KEAP1
* Mouse
* NRF2
* Salivary glands
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7322188
}}
{{medline-entry
|title=Adaptation of the master antioxidant response connects metabolism, lifespan and feather development pathways in birds.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32424161
 
|mesh-terms=* Adaptation, Physiological
* Animals
* Antioxidants
* Basal Metabolism
* Biological Evolution
* Birds
* Cell Nucleus
* Feathers
* Fibroblasts
* Genomics
* Glutathione Transferase
* HEK293 Cells
* Humans
* Kelch-Like ECH-Associated Protein 1
* Longevity
* NF-E2-Related Factor 2
* Oxidative Stress
* Phylogeny
* Proteasome Endopeptidase Complex
* Protein Binding
* Protein Transport
* Ubiquitination
* Up-Regulation
 
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7234996
}}
==KIN==
 
{{medline-entry
|title=The noncanonical small heat shock protein HSP-17 from [i]Caenorhabditis elegans[/i] is a selective protein aggregase.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32001616
 
|mesh-terms=* Animals
* Caenorhabditis elegans
* Caenorhabditis elegans Proteins
* Casein Kinase I
* Heat-Shock Proteins, Small
* Longevity
* Malate Dehydrogenase
* Peptides
* Protein Aggregates
* Protein Folding
* RNA Interference
* RNA, Small Interfering
* Recombinant Proteins
|keywords=* Caenorhabditis elegans (C. elegans)
* chaperone
* protein aggregates
* protein aggregation
* protein folding
* proteostasis
* selective protein aggregase
* small heat shock protein (sHsp)
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7062175
}}
==KIT==
 
{{medline-entry
|title=Prediction of ovarian aging using ovarian expression of BMP15, GDF9, and C-[[KIT]].
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32223330
 
 
|keywords=* BMP15
* C-KIT
* GDF9
* Ovarian aging
* biomarkers
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7221484
}}
==KLF2==
 
{{medline-entry
|title=[[KLF2]] induces the senescence of pancreatic cancer cells by cooperating with FOXO4 to upregulate p21.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31866399
 
|mesh-terms=* Animals
* Carcinogenesis
* Cell Cycle Proteins
* Cell Line
* Cells, Cultured
* Cellular Senescence
* Cyclin-Dependent Kinase Inhibitor p21
* Forkhead Transcription Factors
* Kruppel-Like Transcription Factors
* Male
* Mice
* Mice, Nude
* Pancreatic Neoplasms
* Protein Binding
* Up-Regulation
|keywords=* FOXO4
* KLF2
* Pancreatic cancer
* Senescence
|full-text-url=https://sci-hub.do/10.1016/j.yexcr.2019.111784
}}
==KLF4==
 
{{medline-entry
|title=Extracellular Vesicles from Healthy Cells Improves Cell Function and Stemness in Premature Senescent Stem Cells by miR-302b and HIF-1α Activation.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32630449
 
 
|keywords=* aging
* extracellular vesicles
* oxygen
* physiological oxygen concentration
* physioxia
* redox
* senescence
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7357081
}}
{{medline-entry
|title=Soluble klotho regulates the function of salivary glands by activating [[KLF4]] pathways.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31581134
 
|mesh-terms=* Animals
* Cells, Cultured
* Down-Regulation
* Gene Expression Regulation
* Glucuronidase
* HEK293 Cells
* Humans
* Kruppel-Like Transcription Factors
* Membrane Proteins
* Mice
* Mice, Knockout
* Nuclear Proteins
* RNA Interference
* RNA, Small Interfering
* Salivary Glands
|keywords=* KLF4
* aging
* salivary gland
* soluble klotho
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6814581
}}
==KLF6==
 
{{medline-entry
|title=Krüppel-Like Factor 6 Is Required for Oxidative and Oncogene-Induced Cellular Senescence.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31824948
 
 
|keywords=* DNA damage
* KLF6
* cell proliferation
* cellular senescence
* ras oncogene
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6882731
}}
==KRAS==
 
{{medline-entry
|title=Chemical Pathology of Homocysteine VIII. Effects of Tocotrienol, Geranylgeraniol, and Squalene on Thioretinaco Ozonide, Mitochondrial Permeability, and Oxidative Phosphorylation in Arteriosclerosis, Cancer, Neurodegeneration and Aging.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/33067202
 
 
|keywords=* adenosine triphosphate
* aging
* antioxidant
* apoptosis
* atherogenesis
* cancer
* carcinogenesis
* cholesterol
* free radical
* geraniol
* geranylgeraniol
* homocysteine
* menoquinone
* mitochondrial dysfunction
* mitochondrial membrane potential
* mitochondrial permeability transition pore
* mitophagy
* neuro-degeneration
* oxidative phosphorylation
* oxidative stress
* squalene
* statin
* stellate cells
* testosterone
* thioretinaco ozonide
* thioretinamide
* tocopherol
* tocotrienol
* ubiquinone
 
}}
{{medline-entry
|title=Senescence-Induced Vascular Remodeling Creates Therapeutic Vulnerabilities in Pancreas Cancer.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32234521
 
|mesh-terms=* Aging
* Animals
* CD8-Positive T-Lymphocytes
* Carcinoma, Pancreatic Ductal
* Cell Line, Tumor
* Cell Proliferation
* Cyclin-Dependent Kinase 4
* Cyclin-Dependent Kinase 6
* Gene Expression Regulation, Neoplastic
* Genes, ras
* Humans
* Immunotherapy
* MAP Kinase Signaling System
* Mice
* Pancreatic Neoplasms
* Retinoblastoma Protein
* Signal Transduction
* Tumor Microenvironment
* Vascular Remodeling
|keywords=* T cells
* chemotherapy resistance
* endothelial cell activation
* immunotherapy
* pancreatic cancer
* senescence
* senescence-associated secretory phenotype
* targeted therapy
* tumor microenvironment
* vascular biology
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7278897
}}
==L1CAM==
 
{{medline-entry
|title=Glioma malignancy is linked to interdependent and inverse AMOG and L1 adhesion molecule expression.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31510944
 
|mesh-terms=* Adenosine Triphosphatases
* Apoptosis
* Biomarkers
* Brain Neoplasms
* Cation Transport Proteins
* Cell Adhesion
* Cell Adhesion Molecules, Neuronal
* Cell Line, Tumor
* Cellular Senescence
* Gene Expression Profiling
* Gene Expression Regulation, Neoplastic
* Glioblastoma
* Humans
* Immunohistochemistry
* Neural Cell Adhesion Molecule L1
* RNA, Small Interfering
* Signal Transduction
|keywords=* AMOG
* Apoptosis
* Glioma
* Human
* L1CAM
* Senescence
* Therapy
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6739972
}}
==LAG3==
 
{{medline-entry
|title=T Cell Transcriptional Profiling and Immunophenotyping Uncover [[LAG3]] as a Potential Significant Target of Immune Modulation in Multiple Myeloma.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31445183
 
 
|keywords=* Autologous stem cell transplant
* Exhaustion
* LAG3
* Multiple myeloma
* Senescence
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6952061
}}
==LAMP1==
 
{{medline-entry
|title=Differential accumulation of storage bodies with aging defines discrete subsets of microglia in the healthy brain.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32579115
 
 
|keywords=* CLN3
* TREM2
* aging
* autofluorescence
* immunology
* inflammation
* lysosomal storage disorder
* microglia
* mouse
* neuroscience
* rhesus macaque
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7367682
}}
==LBP==
 
{{medline-entry
|title=Lipopolysaccharide binding protein is associated with CVD risk in older adults.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32895891
 
 
|keywords=* Aging
* Cardiovascular disease risk
* Intestinal permeability
* Lipopolysaccharide binding protein
|full-text-url=https://sci-hub.do/10.1007/s40520-020-01684-z
}}
{{medline-entry
|title=Aging-related liver degeneration is associated with increased bacterial endotoxin and lipopolysaccharide binding protein levels.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32090603
 
|mesh-terms=* Acute-Phase Proteins
* Aging
* Animals
* Apoptosis
* Biomarkers
* Carrier Proteins
* Endotoxins
* Female
* Gene Expression Regulation
* Glucose
* Inflammation
* Insulin Receptor Substrate Proteins
* Liver
* Liver Cirrhosis
* Malate Dehydrogenase
* Male
* Membrane Glycoproteins
* Mice
* Mice, Inbred C57BL
* Mice, Knockout
* RNA, Messenger
* Receptor, Insulin
* Toll-Like Receptor 4
|keywords=* Tlr-4 signaling
* aging
* bacterial endotoxin
* lipopolysaccharide binding protein
* liver degeneration
|full-text-url=https://sci-hub.do/10.1152/ajpgi.00345.2018
}}
{{medline-entry
|title=Biomarkers of leaky gut are related to inflammation and reduced physical function in older adults with cardiometabolic disease and mobility limitations.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31654268
 
|mesh-terms=* Aged
* Aging
* Biomarkers
* Exercise Therapy
* Female
* Follow-Up Studies
* Humans
* Inflammation
* Male
* Metabolic Syndrome
* Middle Aged
* Mobility Limitation
* Motor Activity
* Obesity
* Retrospective Studies
* Weight Loss
|keywords=* Ageing
* Lipopolysaccharide-binding protein
* Microbial translocation
* Physical function
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6925090
}}
{{medline-entry
|title=Needle-shaped amyloid deposition in rat mammary gland: evidence of a novel amyloid fibril protein.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31615282
 
|mesh-terms=* Aging
* Amyloidogenic Proteins
* Amyloidosis
* Animals
* Antigens, Surface
* Female
* Mammary Glands, Animal
* Milk Proteins
* Plaque, Amyloid
* Rats
* Rats, Sprague-Dawley
|keywords=* Amyloidosis
* lipopolysaccharide binding protein
* mammary gland
* pathology
* rat
|full-text-url=https://sci-hub.do/10.1080/13506129.2019.1675623
}}
{{medline-entry
|title=Effects of Lycium barbarum Polysaccharides on Health and Aging of [i]C. elegans[/i] Depend on [i]daf-12/daf-16[/i].
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31583041
 
|mesh-terms=* Aging
* Animals
* Caenorhabditis elegans
* Caenorhabditis elegans Proteins
* Drugs, Chinese Herbal
* Receptors, Cytoplasmic and Nuclear
 
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6754959
}}
==LBR==
 
{{medline-entry
|title=Lamin B receptor: role on chromatin structure, cellular senescence and possibly aging.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32726434
 
 
|keywords=* Aging
* cancer
* cellular senescence
* chromatine structure
* nuclear envelop
|full-text-url=https://sci-hub.do/10.1042/BCJ20200165
}}
{{medline-entry
|title=The impact of age beyond ploidy: outcome data from 8175 euploid single embryo transfers.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32173784
 
 
|keywords=* Aneuploidy
* Pregestational genetic testing
* Reproductive aging
* Single embryo transfer
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7125286
}}
{{medline-entry
|title=The role of lamin B receptor in the regulation of senescence-associated secretory phenotype (SASP).
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32126237
 
 
|keywords=* Gene expression
* LBR
* SAHF
* SASP
* Senescence
|full-text-url=https://sci-hub.do/10.1016/j.yexcr.2020.111927
}}
{{medline-entry
|title=Lamin B receptor plays a key role in cellular senescence induced by inhibition of the proteasome.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31825172
 
 
|keywords=* LBR
* autophagy
* proteasome
* protein accumulation
* senescence
* unbalanced growth
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6996348
}}
==LEP==
 
{{medline-entry
|title=Age- and Sex-Specific Changes in Lower-Limb Muscle Power Throughout the Lifespan.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31943003
 
 
|keywords=* Aging
* Body mass index
* Dynapenia
* Leg extension power
* Sarcopenia
* Skeletal muscle
|full-text-url=https://sci-hub.do/10.1093/gerona/glaa013
}}
{{medline-entry
|title=The Copenhagen Sarcopenia Study: lean mass, strength, power, and physical function in a Danish cohort aged 20-93 years.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31419087
 
|mesh-terms=* Adult
* Aged
* Aged, 80 and over
* Body Composition
* Cohort Studies
* Cross-Sectional Studies
* Denmark
* Female
* Hand Strength
* Humans
* Leg
* Longevity
* Middle Aged
* Prospective Studies
* Sarcopenia
* Young Adult
|keywords=* Body composition
* DXA
* Handgrip strength
* Lean mass
* Leg power
* Sarcopenia
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6903448
}}
==LGR6==
 
{{medline-entry
|title=Effect of defensins-containing eye cream on periocular rhytids and skin quality.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32614135
 
 
|keywords=* aging
* defensins
* periocular
* rhytids
* skin
|full-text-url=https://sci-hub.do/10.1111/jocd.13424
}}
==LHCGR==
 
{{medline-entry
|title=Comparative Study of the Steroidogenic Effects of Human Chorionic Gonadotropin and Thieno[2,3-D]pyrimidine-Based Allosteric Agonist of Luteinizing Hormone Receptor in Young Adult, Aging and Diabetic Male Rats.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/33050653
 
 
|keywords=* aging rats
* diabetes mellitus
* human chorionic gonadotropin
* low-molecular-weight agonist
* luteinizing hormone receptor
* spermatogenesis
* steroidogenesis
* testes
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7590010
}}
==LMNA==
 
{{medline-entry
|title=Metformin alters peripheral blood mononuclear cells (PBMC) senescence biomarkers gene expression in type 2 diabetic patients.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/33187870
 
 
|keywords=* Inflammation and cellular senescence
* Insulin resistance
* LMNA/C transcript variants
* Mononuclear cells
* Type 2 diabetes mellitus
|full-text-url=https://sci-hub.do/10.1016/j.jdiacomp.2020.107758
}}
{{medline-entry
|title=Protein structural and mechanistic basis of progeroid laminopathies.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32799420
 
 
|keywords=* 3D structure
* aging disorders
* contact sites
* lamin
* nuclear structure
|full-text-url=https://sci-hub.do/10.1111/febs.15526
}}
{{medline-entry
|title=Progerin Expression Induces Inflammation, Oxidative Stress and Senescence in Human Coronary Endothelial Cells.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32408587
 
 
|keywords=* Hutchinson–Gilford progeria syndrome
* LMNA
* aging
* atherosclerosis
* endothelial dysfunction
* inflammation
* lamin A
* prenylation
* progerin
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7290406
}}
{{medline-entry
|title=The JAK1/2 inhibitor ruxolitinib delays premature aging phenotypes.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32196928
 
 
|keywords=* JAK/STAT pathway
* cellular senescence
* progeria
* ruxolitinib
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7189991
}}
{{medline-entry
|title=Pharmacotherapy to gene editing: potential therapeutic approaches for Hutchinson-Gilford progeria syndrome.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32048129
 
 
|keywords=* Aging
* Extracellular vesicles
* Hutchinson–Gilford progeria syndrome
* Progerin
* Stem cells
* Therapeutics
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7205988
}}
{{medline-entry
|title=Long term breeding of the Lmna G609G progeric mouse: Characterization of homozygous and heterozygous models.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31794853
 
 
|keywords=* Aging
* Animal model breeding
* Bone strength
* Hutchinson-Gilford Progeria Syndrome (HGPS)
* Kyphosis
* Quality of life
|full-text-url=https://sci-hub.do/10.1016/j.exger.2019.110784
}}
==LMNB1==
 
{{medline-entry
|title=SIRT1 - a new mammalian substrate of nuclear autophagy.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/33292048
 
 
|keywords=* Aging
* SIRT1
* nuclear autophagy
* senescence
* sirtuin
|full-text-url=https://sci-hub.do/10.1080/15548627.2020.1860541
}}
{{medline-entry
|title=Cellular senescence as a response to multiwalled carbon nanotube (MWCNT) exposure in human mesothelial cells.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/33279583
 
 
|keywords=* alpha tubulin
* cellular senescence
* mesothelial cells
* microarray analysis
* multiwalled carbon nanotubes
* γH2A.X
|full-text-url=https://sci-hub.do/10.1016/j.mad.2020.111412
}}
{{medline-entry
|title=Inflammatory Drivers of Cardiovascular Disease: Molecular Characterization of Senescent Coronary Vascular Smooth Muscle Cells.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32523550
 
 
|keywords=* aging
* cardiovascular
* inflammation
* senescence
* smooth muscle cell
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7261939
}}
==LOX==
 
{{medline-entry
|title=12-[[LOX]] catalyzes the oxidation of 2-arachidonoyl-lysolipids in platelets generating eicosanoid-lysolipids that are attenuated by iPLA γ knockout.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32161117
 
 
|keywords=* 2-arachidonoyl-lysophospholipids
* aging
* calcium
* eicosanoid
* iPLA2γ
* lysophospholipid
* myocardium
* platelet
* platelet-type 12-lipoxygenase (12-LOX)
* polyunsaturated fatty acids (PUFAs)
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7170522
}}
==LOXL1==
 
{{medline-entry
|title=A blackberry-dill extract combination synergistically increases skin elasticity.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32583541
 
 
|keywords=* blackberry-dill
* elasticity
* skin aging
* skin physiology/structure
* skin repair
|full-text-url=https://sci-hub.do/10.1111/ics.12644
}}
==LOXL2==
 
{{medline-entry
|title=Lysyl Oxidase-Like 2 Protects against Progressive and Aging Related Knee Joint Osteoarthritis in Mice.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31569601
 
|mesh-terms=* Adenoviridae
* Aging
* Amino Acid Oxidoreductases
* Animals
* Arthritis, Experimental
* Cartilage, Articular
* Disease Models, Animal
* Disease Progression
* Gene Expression
* Gene Transfer Techniques
* Genetic Vectors
* Interleukin-1beta
* Mice
* Mice, Transgenic
* NF-kappa B
* Osteoarthritis, Knee
* Transduction, Genetic
|keywords=* Lysyl oxidase like-2
* adenovirus delivery
* anabolic response
* articular cartilage
* knee joint
* osteoarthritis
* regeneration
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6801581
}}
==LPA==
 
{{medline-entry
|title=Ginseng gintonin, aging societies, and geriatric brain diseases.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32817818
 
 
|keywords=* Brain aging
* Gintonin
* Neurodegenerative diseases
* Panax ginseng
* Rejuvenation
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7426447
}}
{{medline-entry
|title=Late-life related subtypes of depression - a data-driven approach on cognitive domains and physical frailty.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32442243
 
 
|keywords=* cognitive aging
* depression
* frailty
|full-text-url=https://sci-hub.do/10.1093/gerona/glaa110
}}
{{medline-entry
|title=Does sedentary time increase in older adults in the days following participation in intense exercise?
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32130714
 
|mesh-terms=* Accelerometry
* Aged
* Exercise
* Exercise Test
* Humans
* Sedentary Behavior
* Sleep
|keywords=* Aging
* Compensation
* High intensity
* Movement behaviours
|full-text-url=https://sci-hub.do/10.1007/s40520-020-01502-6
}}
{{medline-entry
|title=Association of Long-term Exposure to Elevated Lipoprotein(a) Levels With Parental Life Span, Chronic Disease-Free Survival, and Mortality Risk: A Mendelian Randomization Analysis.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32108890
 
|mesh-terms=* Aged
* Case-Control Studies
* Cross-Sectional Studies
* Female
* Humans
* Lipoprotein(a)
* Longevity
* Male
* Mendelian Randomization Analysis
* Middle Aged
* Parents
* Phenotype
* Prospective Studies
* Risk Factors
 
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7049087
}}
{{medline-entry
|title=Elevated Autotaxin and [[LPA]] Levels During Chronic Viral Hepatitis and Hepatocellular Carcinoma Associate with Systemic Immune Activation.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31769428
 
 
|keywords=* Aging
* Autotaxin
* Hepatitis
* Hepatocellular Carcinoma
* Immune Activation
* Immunity
* Inflammation
* Liver
* Lysophosphatidic Acid
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6966516
}}
{{medline-entry
|title=Lysophosphatidic acid receptor [[LPA]]  prevents oxidative stress and cellular senescence in Hutchinson-Gilford progeria syndrome.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31714004
 
 
|keywords=* 1-Oleoyl-2-O-methyl-rac-glycerophosphothionate
* Hutchinson-Gilford progeria syndrome
* LPA3
* cell senescence
* lysophosphatidic acid
* reactive oxygen species
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6974717
}}
{{medline-entry
|title=Associations of Sedentary and Physically-Active Behaviors With Cognitive-Function Decline in Community-Dwelling Older Adults: Compositional Data Analysis From the NEIGE Study.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31656243
 
 
|keywords=* accelerometry
* aging
* exercise
* neurocognitive disorders
* sedentary lifestyle
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7557173
}}
{{medline-entry
|title=Validation and comparison of two automated methods for quantifying brain white matter hyperintensities of presumed vascular origin.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31612759
 
 
|keywords=* White matter hyperintensity
* brain aging
* cerebral small vessel disease
* lesion segmentation
* methodology
* validation
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7607266
}}
{{medline-entry
|title=The Sedentary Time and Physical Activity Levels on Physical Fitness in the Elderly: A Comparative Cross Sectional Study.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31581429
 
|mesh-terms=* Accelerometry
* Aged
* Aged, 80 and over
* Aging
* Body Mass Index
* Cross-Sectional Studies
* Exercise
* Female
* Humans
* Male
* Physical Fitness
* Sedentary Behavior
|keywords=* accelerometry
* ageing
* health
* physical fitness
* sedentary behaviour
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6801920
}}
{{medline-entry
|title=Light-Intensity Physical Activity in a Large Prospective Cohort of Older US Adults: A 21-Year Follow-Up of Mortality.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31600755
 
|mesh-terms=* Aged
* Cardiovascular Diseases
* Cohort Studies
* Exercise
* Female
* Follow-Up Studies
* Humans
* Leisure Activities
* Male
* Middle Aged
* Mortality
* Neoplasms
* Proportional Hazards Models
* Prospective Studies
* Respiratory Tract Diseases
* Risk Factors
* Surveys and Questionnaires
* United States
|keywords=* Aging
* Cancer prevention study
* Leisure time physical activity
* Light-intensity physical activity
|full-text-url=https://sci-hub.do/10.1159/000502860
}}
==LPL==
 
{{medline-entry
|title=Survival analyses in Holstein cows considering direct disease diagnoses and specific SNP marker effects.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32684467
 
 
|keywords=* SNP effect
* Weibull hazards model
* genetic parameter
* health disorder
* longevity
|full-text-url=https://sci-hub.do/10.3168/jds.2020-18174
}}
{{medline-entry
|title=Influence of common health disorders on the length of productive life and stayability in German Holstein cows.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31677834
 
|mesh-terms=* Animals
* Breeding
* Cattle
* Cattle Diseases
* Dairying
* Farmers
* Female
* Lactation
* Longevity
* Phenotype
|keywords=* genetic parameter
* health disorder
* longevity
* subjective culling reason
|full-text-url=https://sci-hub.do/10.3168/jds.2019-16985
}}
==LPO==
 
{{medline-entry
|title=[Features of the changes in lipid peroxidation and activity of Na+/K+-ATPase in the brain of the aged rats in the conditions of two-vessel cerebral ischemia/reperfusion.]
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32160433
 
|mesh-terms=* Aging
* Animals
* Brain Ischemia
* Disease Models, Animal
* Lipid Peroxidation
* Rats
* Reperfusion Injury
* Sodium-Potassium-Exchanging ATPase
|keywords=* Na+/K+-ATPase
* aging
* brain
* lipid peroxidation
* oxidative stress
* stroke
 
}}
==LRP1==
 
{{medline-entry
|title=Drug Targeting of Plasminogen Activator Inhibitor-1 Inhibits Metabolic Dysfunction and Atherosclerosis in a Murine Model of Metabolic Syndrome.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32268785
 
|mesh-terms=* Animals
* Atherosclerosis
* Cellular Senescence
* Diet, Western
* Disease Models, Animal
* Indoleacetic Acids
* Macrophages
* Metabolic Syndrome
* Mice
* Mice, Knockout
* Obesity
* Plaque, Atherosclerotic
* Plasminogen Activator Inhibitor 1
* Receptors, LDL
|keywords=* atherosclerosis
* cellular senescence
* fibrinolysis
* metabolic syndrome
* muscle, smooth
* obesity
* plasminogen activator inhibitor-1
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7255962
}}
==LRP4==
 
{{medline-entry
|title=Multiple MuSK signaling pathways and the aging neuromuscular junction.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32353380
 
 
|keywords=* Aging
* BMP signaling
* MuSK
* Neuromuscular junction
* Synaptic maintenance
|full-text-url=https://sci-hub.do/10.1016/j.neulet.2020.135014
}}
==LRP6==
 
{{medline-entry
|title=Low-density lipoprotein receptor-related protein 6-mediated signaling pathways and associated cardiovascular diseases: diagnostic and therapeutic opportunities.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32076828
 
|mesh-terms=* Aging
* Animals
* Cardiovascular Diseases
* Humans
* Low Density Lipoprotein Receptor-Related Protein-6
* Muscle, Smooth, Vascular
* Myocytes, Smooth Muscle
* Obesity
* Signal Transduction
* Structure-Activity Relationship
* Vascular Calcification
* Wnt Signaling Pathway
 
|full-text-url=https://sci-hub.do/10.1007/s00439-020-02124-8
}}
==LRRK2==
 
{{medline-entry
|title=Accelerated telomere shortening independent of [[LRRK2]] variants in Chinese patients with Parkinson's disease.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/33122450
 
 
|keywords=* LRRK2 variants
* Parkinson’s disease
* aging
* telomere length
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7655166
}}
{{medline-entry
|title=The effect of [[LRRK2]] loss-of-function variants in humans.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32461697
 
|mesh-terms=* Adult
* Aged
* Aged, 80 and over
* Biological Specimen Banks
* Cell Line
* Embryonic Stem Cells
* Female
* Gain of Function Mutation
* Heterozygote
* Humans
* Leucine-Rich Repeat Serine-Threonine Protein Kinase-2
* Longevity
* Loss of Function Mutation
* Lymphocytes
* Male
* Middle Aged
* Myocytes, Cardiac
* Parkinson Disease
* Phenotype
 
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7303015
}}
{{medline-entry
|title=Parkinson's disease-related Leucine-rich repeat kinase 2 modulates nuclear morphology and genomic stability in striatal projection neurons during aging.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32075681
 
 
|keywords=* And aging
* Dendritic hypotrophy
* Excitability
* G2019S
* GABAA
* LRRK2
* Nuclear DNA damage
* Nuclear hypertrophy
* Nuclear invagination
* Parkinson’s disease
* R1441C
* Striatal spiny projection neuron
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7031993
}}
{{medline-entry
|title=Autophagy and [[LRRK2]] in the Aging Brain.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31920513
 
 
|keywords=* LAMP2A
* LC3
* LRRK2
* Parkinson’s disease
* aging
* autophagy
* lysosomes
* α-synuclein
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6928047
}}
==LSS==
 
{{medline-entry
|title=Surgical results in older patients with lumbar spinal stenosis according to gait speed in relation to the diagnosis for sarcopenia.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32329390
 
 
|keywords=* aging
* elderly person
* gait speed
* lumbar spinal stenosis
* lumbar spine
* muscle strength
* sarcopenia
* skeletal muscle mass
* surgical result
|full-text-url=https://sci-hub.do/10.1177/2309499020918422
}}
{{medline-entry
|title=Streamlining an existing hip fracture patient pathway in an acute tertiary adult Irish hospital to improve patient experience and outcomes.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31867664
 
|mesh-terms=* Aged
* Aged, 80 and over
* Delivery of Health Care, Integrated
* Geriatrics
* Hip Fractures
* Hospitals, Teaching
* Humans
* Ireland
* Length of Stay
* Nerve Block
* Orthopedics
* Pain Management
* Total Quality Management
* Treatment Outcome
|keywords=* Lean Six Sigma
* healthcare outcomes
* hip fracture care
* integrated care pathways
* interdisciplinary working
* process improvement
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6926383
}}
==LTA==
 
{{medline-entry
|title=Lipoteichoic acid from the cell wall of a heat killed Lactobacillus paracasei D3-5 ameliorates aging-related leaky gut, inflammation and improves physical and cognitive functions: from C. elegans to mice.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31814084
 
 
|keywords=* Aging
* Cell wall
* Cognition
* Goblet cell
* Inflammation
* Leaky gut
* Lipoteichoic acid
* Metabolism
* Mucin
* Physical function
* Probiotics
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7031475
}}
{{medline-entry
|title=The change of pain classes over time: a latent transition analysis.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31680381
 
|mesh-terms=* Aged
* Aging
* Humans
* Life Style
* Longitudinal Studies
* Middle Aged
* Pain
* Quality of Life
 
|full-text-url=https://sci-hub.do/10.1002/ejp.1502
}}
==LY6D==
 
{{medline-entry
|title=[[LY6D]]-induced macropinocytosis as a survival mechanism of senescent cells.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/33168631
 
 
|keywords=* LY6D
* Ras protein
* cellular senescence
* endocytosis
* lipid raft
* macropinocytosis
* vacuole
|full-text-url=https://sci-hub.do/10.1074/jbc.RA120.013500
}}
==MAG==
 
{{medline-entry
|title=Exploration of life satisfaction of Korean people with sensory impairments across the lifespan.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32327387
 
 
|keywords=* Across the lifespan
* Leisure domain
* Life satisfaction
* Sensory impairment
* Social domain
|full-text-url=https://sci-hub.do/10.1016/j.dhjo.2020.100931
}}
==MALT1==
 
{{medline-entry
|title=MALT-1 mediates IL-17 neural signaling to regulate C. elegans behavior, immunity and longevity.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32350248
 
|mesh-terms=* Animals
* Behavior, Animal
* Caenorhabditis elegans
* Caenorhabditis elegans Proteins
* Gene Expression Regulation
* Green Fluorescent Proteins
* Immunity
* Interleukin-17
* Interneurons
* Longevity
* Models, Biological
* Mucosa-Associated Lymphoid Tissue Lymphoma Translocation 1 Protein
* Neurons
* Oxygen
* Signal Transduction
* Subcellular Fractions
* Transgenes
 
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7190641
}}
{{medline-entry
|title=[[MALT1]]-Deficient Mice Develop Atopic-Like Dermatitis Upon Aging.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31632405
 
|mesh-terms=* Age Factors
* Animals
* CTLA-4 Antigen
* Cytokines
* Dermatitis, Atopic
* Disease Models, Animal
* Disease Susceptibility
* Gene Expression
* Genetic Predisposition to Disease
* Immunoglobulin E
* Lymphocyte Activation
* Mice
* Mice, Knockout
* Mucosa-Associated Lymphoid Tissue Lymphoma Translocation 1 Protein
* Skin
* T-Lymphocyte Subsets
|keywords=* MALT1
* Th2
* Tregs
* aging
* atopic dermatitis
* lymphocytes
* skin inflammation
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6779721
}}
==MAP2==
 
{{medline-entry
|title=Protective effects of ischemic preconditioning against neuronal apoptosis and dendritic injury in the hippocampus are age-dependent.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32314365
 
 
|keywords=* aging
* diffusion tensor imaging
* immunohistochemistry
* ischemic preconditioning
|full-text-url=https://sci-hub.do/10.1111/jnc.15029
}}
==MAP4K3==
 
{{medline-entry
|title=[[MAP4K3]]/GLK in autoimmune disease, cancer and aging.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31640697
 
|mesh-terms=* Aging
* Autoimmune Diseases
* Humans
* Neoplasms
* Protein-Serine-Threonine Kinases
|keywords=* Aging
* Autoimmune disease
* Autophagy
* Cancer metastasis
* HPK1
* IL-17A
* IQGAP1
* MAP4K3 (GLK)
* PKCθ
* Verteporfin
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6806545
}}
==MAPK1==
 
{{medline-entry
|title=Purified Vitexin Compound 1 Inhibits UVA-Induced Cellular Senescence in Human Dermal Fibroblasts by Binding Mitogen-Activated Protein Kinase 1.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32850814
 
 
|keywords=* MAPK1
* VB1
* purified vitexin compound 1
* senescence
* skin photoaging
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7413062
}}
==MAPKAPK2==
 
{{medline-entry
|title=Quantitative In Vivo Proteomics of Metformin Response in Liver Reveals AMPK-Dependent and -Independent Signaling Networks.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31801093
 
|mesh-terms=* AMP-Activated Protein Kinases
* Animals
* Calcium
* Cell Line
* Endocytosis
* HEK293 Cells
* Homeostasis
* Humans
* Intracellular Signaling Peptides and Proteins
* Liver
* Metformin
* Mice
* Phosphorylation
* Protein Kinase C
* Protein-Serine-Threonine Kinases
* Proteomics
* Signal Transduction
|keywords=* AMPK3
* LKB1
* PKD1
* STIM1
* aging
* calcium
* diabetes
* kinases
* liver
* metformin
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6980792
}}
==MAPT==
 
{{medline-entry
|title=Association of relative brain age with tobacco smoking, alcohol consumption, and genetic variants.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32001736
 
|mesh-terms=* Aged
* Aged, 80 and over
* Aging
* Alcohol Drinking
* Biological Specimen Banks
* Brain
* Cognition
* Female
* Humans
* Magnetic Resonance Imaging
* Male
* Middle Aged
* Neuroimaging
* Polymorphism, Single Nucleotide
* Smoking
* United Kingdom
* tau Proteins
 
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6992742
}}
{{medline-entry
|title=A blood-based nutritional risk index explains cognitive enhancement and decline in the multidomain Alzheimer prevention trial.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31921969
 
 
|keywords=* Aging
* Biomarkers of diet quality
* Cognitive decline
* DHA
* EPA
* Elderly
* Homocysteine
* Metabolomics
* Nutrient biomarkers
* Omega-3 fatty acids
* Vitamin D
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6944714
}}
{{medline-entry
|title=Longitudinal associations of physical activity levels with morphological and functional changes related with aging: The [[MAPT]] study.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31669813
 
|mesh-terms=* Aged
* Aged, 80 and over
* Aging
* Alzheimer Disease
* Body Composition
* Brain
* Cognition
* Exercise
* Female
* Humans
* Longitudinal Studies
* Male
|keywords=* Aging
* Biomarkers
* Phenotype
* Physical activity
|full-text-url=https://sci-hub.do/10.1016/j.exger.2019.110758
}}
{{medline-entry
|title=Ageing and amyloidosis underlie the molecular and pathological alterations of tau in a mouse model of familial Alzheimer's disease.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31673052
 
|mesh-terms=* Aging
* Alzheimer Disease
* Amyloid beta-Peptides
* Amyloidosis
* Animals
* Disease Models, Animal
* Mice
* Mice, Transgenic
* tau Proteins
 
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6823454
}}
{{medline-entry
|title=Revisiting the intersection of amyloid, pathologically modified tau and iron in Alzheimer's disease from a ferroptosis perspective.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31604111
 
 
|keywords=* Alzheimer’s disease
* Ferroptosis
* Iron
* Reactive oxygen species
* Senescence
* Tau
|full-text-url=https://sci-hub.do/10.1016/j.pneurobio.2019.101716
}}
==MATN3==
 
{{medline-entry
|title=Mice Lacking the Matrilin Family of Extracellular Matrix Proteins Develop Mild Skeletal Abnormalities and Are Susceptible to Age-Associated Osteoarthritis.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31963938
 
|mesh-terms=* Aging
* Animals
* Cell Proliferation
* Cells, Cultured
* Chondrocytes
* Disease Models, Animal
* Female
* Gene Knockout Techniques
* Humans
* Male
* Matrilin Proteins
* Mice
* Mice, Knockout
* Microscopy, Atomic Force
* Muscle, Skeletal
* Osteoarthritis
|keywords=* articular cartilage
* bone development
* cartilage
* matrilin
* osteoarthritis
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7013758
}}
==MB==
 
{{medline-entry
|title=Probing menstrual bloodstain aging with fluorescence spectroscopy.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/33279406
 
 
|keywords=* Aging
* Analytical methods
* Blood
* Fluorescence spectroscopy
* Forensics
|full-text-url=https://sci-hub.do/10.1016/j.saa.2020.119172
}}
{{medline-entry
|title=Effect of physical exercise and medication on enhancing cognitive function in older adults with vascular risk.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32989840
 
|mesh-terms=* Aged
* Aged, 80 and over
* Cognition
* Cross-Sectional Studies
* Exercise
* Exercise Therapy
* Female
* Humans
* Male
* Middle Aged
* Risk Factors
* Vascular Diseases
|keywords=* active aging
* cognitive preservation
* exercise habit
* lifestyle advice
* vascular care
|full-text-url=https://sci-hub.do/10.1111/ggi.14048
}}
{{medline-entry
|title=A novel indenone derivative selectively induces senescence in MDA-[[MB]]-231 (breast adenocarcinoma) cells.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32956706
 
|mesh-terms=* Antineoplastic Agents
* Breast Neoplasms
* Catalysis
* Cell Line, Tumor
* Cell Survival
* Cellular Senescence
* Cyclin-Dependent Kinase Inhibitor p21
* Down-Regulation
* Female
* G1 Phase Cell Cycle Checkpoints
* Humans
* Palladium
* Sulfonamides
* Survivin
* Tumor Suppressor Protein p53
* Up-Regulation
|keywords=* Cell cycle arrest
* Novel indenone derivative
* Senescence
* Triple-negative breast cancer
|full-text-url=https://sci-hub.do/10.1016/j.cbi.2020.109250
}}
{{medline-entry
|title=Improved Autophagic Flux in Escapers from Doxorubicin-Induced Senescence/Polyploidy of Breast Cancer Cells.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32846959
 
 
|keywords=* DNA damage
* Rubicon
* SQSTM1/p62
* TFEB
* autophagic index
* autophagy
* cancer
* polyploidy
* senescence
* senescence escape
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7504443
}}
{{medline-entry
|title=Lifespan regulation in α/β posterior neurons of the fly mushroom bodies by Rab27.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32627932
 
 
|keywords=* Drosophila
* Rab27
* S6K
* TOR
* lifespan extension
* mushroom body
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7431830
}}
{{medline-entry
|title=Tailored Functionalized Magnetic Nanoparticles to Target Breast Cancer Cells Including Cancer Stem-Like Cells.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32485849
 
 
|keywords=* apoptosis
* cancer stem-like cells
* doxorubicin
* magnetic iron oxide nanoparticles
* mitotic catastrophe
* senescence
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7352336
}}
{{medline-entry
|title="Mitotic Slippage" and Extranuclear DNA in Cancer Chemoresistance: A Focus on Telomeres.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32316332
 
 
|keywords=* ALT
* SQSTM1/p62
* amoeboid conversion
* budding of mitotic progeny
* cellular senescence
* extranuclear DNA
* genotoxic treatment
* inverted meiosis
* mtTP53 cancer
* polyploidization
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7215480
}}
{{medline-entry
|title=Diversity of the Senescence Phenotype of Cancer Cells Treated with Chemotherapeutic Agents.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31771226
 
|mesh-terms=* Antineoplastic Agents
* Cell Proliferation
* Cellular Senescence
* Cyclin-Dependent Kinase Inhibitor p21
* Doxorubicin
* Fluorouracil
* Humans
* Irinotecan
* Methotrexate
* Neoplasms
* Oxaliplatin
* Paclitaxel
* Phenotype
* Tumor Cells, Cultured
|keywords=* DNA damage
* SASP
* cancer
* chemotherapy
* senescence
* senescence markers
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6952928
}}
{{medline-entry
|title=Downregulation of the inflammatory network in senescent fibroblasts and aging tissues of the long-lived and cancer-resistant subterranean wild rodent, Spalax.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31605433
 
 
|keywords=*
Spalax
 
* DNA damage
* DNA repair
* cellular senescence
* interleukin-1 alpha (IL1α)
* nuclear factor κB (NF-κB)
* senescence-associated secretory phenotype (SASP)
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6974727
}}
{{medline-entry
|title=Quantification of the health-status of the Dutch Labrador retriever population.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31494529
 
|mesh-terms=* Animals
* Dog Diseases
* Dogs
* Female
* Health Status
* Insurance
* Laboratories
* Longevity
* Male
* Netherlands
* Proportional Hazards Models
* Risk Factors
|keywords=* Canine health
* Data analysis
* Health parameters
* Labrador retriever
* Lifespan
* Oncology
|full-text-url=https://sci-hub.do/10.1016/j.prevetmed.2019.104764
}}
{{medline-entry
|title=Conjugated Physiological Resveratrol Metabolites Induce Senescence in Breast Cancer Cells: Role of p53/p21 and p16/Rb Pathways, and ABC Transporters.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31441212
 
|mesh-terms=* ATP-Binding Cassette Transporters
* Breast Neoplasms
* Cell Cycle Checkpoints
* Cellular Senescence
* Cyclin-Dependent Kinase Inhibitor p16
* Cyclin-Dependent Kinase Inhibitor p21
* Female
* Glucuronides
* Humans
* MCF-7 Cells
* Resveratrol
* Retinoblastoma Protein
* Signal Transduction
* Stilbenes
* Tumor Suppressor Protein p53
|keywords=* ABC transporters
* breast cancer
* deconjugation
* resveratrol metabolites
* senescence
|full-text-url=https://sci-hub.do/10.1002/mnfr.201900629
}}
==MBP==
 
{{medline-entry
|title=Demyelination associated with chronic arsenic exposure in Wistar rats.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32171569
 
|mesh-terms=* Aging
* Amyloid beta-Protein Precursor
* Animals
* Arsenic Poisoning
* Arsenites
* Axons
* Corpus Callosum
* Demyelinating Diseases
* Diffusion Tensor Imaging
* Drinking Water
* Immunohistochemistry
* Male
* Mitochondria
* Myelin Basic Protein
* Neurofilament Proteins
* Prefrontal Cortex
* Rats
* Rats, Wistar
* Sodium Compounds
* White Matter
|keywords=* Amyloid
* Anisotropy
* Arsenic
* Axonal damage
* DTI
* Demyelination
* Development
* MRI
* Microstructure
* Mitochondria
|full-text-url=https://sci-hub.do/10.1016/j.taap.2020.114955
}}
{{medline-entry
|title=Natural killer cells as participants in pathogenesis of rat experimental autoimmune encephalomyelitis (EAE): lessons from research on rats with distinct age and strain.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32140045
 
 
|keywords=* EAE
* NK cells
* aging
* dendritic cells
* strain differences
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7050050
}}
==MCC==
 
{{medline-entry
|title=Multiple chronic conditions and risk of cognitive impairment and dementia among older Americans: findings from the Aging, Demographics, and Memory Study (ADAMS).
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32633198
 
 
|keywords=* Aging
* and memory study
* cognitive impairment with no dementia
* dementia
* demographics
* multimorbidity
* multiple chronic conditions
|full-text-url=https://sci-hub.do/10.1080/13825585.2020.1790492
}}
{{medline-entry
|title=Behaviour consistency is a sensitive tool for distinguishing the effects of aging on physical activity.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32348871
 
 
|keywords=* Aging
* Behaviour consistency
* Heart rate
* Physical activity
* Treadmill running
|full-text-url=https://sci-hub.do/10.1016/j.bbr.2020.112619
}}
{{medline-entry
|title=Burden on Caregivers of Adults with Multiple Chronic Conditions: Intersectionality of Age, Gender, Education level, Employment Status, and Impact on Social Life.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31475644
 
 
|keywords=* aging
* analyse d’intersectionnalité
* caregiver burden
* fardeau de l’aidant
* gender
* interférence sociale
* intersectionality analysis
* maladies chroniques multiples
* multiple chronic conditions
* sexe
* social interference
* vieillissement
|full-text-url=https://sci-hub.do/10.1017/S071498081900045X
}}
==MCM9==
 
{{medline-entry
|title=MCM8- and [[MCM9]] Deficiencies Cause Lifelong Increased Hematopoietic DNA Damage Driving p53-Dependent Myeloid Tumors.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31509747
 
|mesh-terms=* Aging
* Animals
* Apoptosis
* Bone Marrow
* Cell Differentiation
* Cell Proliferation
* DNA Damage
* Gene Expression Regulation, Leukemic
* Hematologic Neoplasms
* Mice
* Mice, Knockout
* Minichromosome Maintenance Proteins
* Retinoblastoma Protein
* Signal Transduction
* Splenomegaly
* Tumor Suppressor Protein p53
|keywords=* DNA damage
* DNA repair
* MCM8
* MCM9
* cancer
* hematopoiesis
* homologous recombination
* myelodysplastic syndrome
|full-text-url=https://sci-hub.do/10.1016/j.celrep.2019.07.095
}}
==MCU==
 
{{medline-entry
|title=A rare case of Epstein-Barr virus-positive mucocutaneous ulcer that developed into an intestinal obstruction: a case report.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31931725
 
|mesh-terms=* Aged, 80 and over
* Colon, Transverse
* Epstein-Barr Virus Infections
* Herpesvirus 4, Human
* Humans
* Intestinal Mucosa
* Intestinal Obstruction
* Male
* Ulcer
|keywords=* Aging
* Epstein–Barr virus-positive mucocutaneous ulcer (EBV-MCU)
* Immunosuppression
* Intestinal obstruction
* Surgical resection
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6958744
}}
{{medline-entry
|title=Inhibition of Mitochondrial Calcium Overload by SIRT3 Prevents Obesity- or Age-Related Whitening of Brown Adipose Tissue.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31712319
 
|mesh-terms=* Adipocytes, Brown
* Adipose Tissue, Brown
* Aging
* Animals
* Calcium
* Capsaicin
* Gene Expression Regulation
* Mice
* Mice, Knockout
* Mitochondria
* Obesity
* Sirtuin 3
 
|full-text-url=https://sci-hub.do/10.2337/db19-0526
}}
==MDH1==
 
{{medline-entry
|title=Oxidative Damage to the TCA Cycle Enzyme [[MDH1]] Dysregulates Bioenergetic Enzymatic Activity in the Aged Murine Brain.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32175745
 
 
|keywords=* DPM
* MRM
* TCA cycle
* aging
* brain
|full-text-url=https://sci-hub.do/10.1021/acs.jproteome.9b00861
}}
==MDM2==
 
{{medline-entry
|title=SENEBLOC, a long non-coding RNA suppresses senescence via p53-dependent and independent mechanisms.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32030426
 
|mesh-terms=* Aging
* Animals
* Carcinogenesis
* Cyclin-Dependent Kinase Inhibitor p21
* Gene Expression Regulation, Neoplastic
* HCT116 Cells
* Heterografts
* Histone Deacetylases
* Humans
* Mice
* Neoplasms
* Protein Binding
* RNA, Long Noncoding
* Signal Transduction
* Tumor Suppressor Protein p53
 
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7102969
}}
{{medline-entry
|title=Disruption of Robo2-Baiap2 integrated signaling drives cystic disease.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31534052
 
|mesh-terms=* Animals
* Cell Differentiation
* Cell Proliferation
* Cellular Senescence
* Cilia
* Disease Models, Animal
* Epithelial Cells
* Humans
* Kidney
* Kidney Diseases, Cystic
* Mice
* Mice, Knockout
* Nerve Tissue Proteins
* Protein Binding
* Protein Domains
* Receptors, Immunologic
* Signal Transduction
* Tumor Suppressor Protein p53
|keywords=* Cellular senescence
* Development
* Genetic diseases
* Nephrology
* Signal transduction
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6795383
}}
{{medline-entry
|title=Senescence-induced immunophenotype, gene expression and electrophysiology changes in human amniocytes.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31478614
 
|mesh-terms=* Amniocentesis
* Amnion
* Biomarkers
* Cell Proliferation
* Cells, Cultured
* Cellular Senescence
* Electrophysiological Phenomena
* Female
* Gene Expression Regulation
* Humans
* Immunophenotyping
* Phenotype
|keywords=* amniocyte
* automated patch-clamp
* flow cytometry
* mesenchymal stem cell
* qRT-PCR
* replicative senescence
* senescence-associated secretory phenotype
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6815807
}}
==MED25==
 
{{medline-entry
|title=The [i]HAC1[/i] histone acetyltransferase promotes leaf senescence and regulates the expression of [i]ERF022[/i].
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31468026
 
 
|keywords=* ERF022
* H3K9ac
* HAC1
* Mediator complex
* histone acetylation
* leaf senescence
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6710649
}}
==MEFV==
 
{{medline-entry
|title=The grandfather's fever.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31401792
 
|mesh-terms=* Age of Onset
* Aged, 80 and over
* Familial Mediterranean Fever
* Female
* Humans
* Male
* Pedigree
* Pyrin
|keywords=* Autoinflammatory diseases
* FMF
* Genetics
* Geriatrics
* Periodic fever
|full-text-url=https://sci-hub.do/10.1007/s10067-019-04741-9
}}
==MEOX2==
 
{{medline-entry
|title=Reduced expression of microRNA-130a promotes endothelial cell senescence and age-dependent impairment of neovascularization.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32457253
 
 
|keywords=* aging
* angiogenesis
* microRNA
* neovascularization
* senescence
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7346016
}}
==MET==
 
{{medline-entry
|title=Self-rated health in relation to fruit and vegetable consumption and physical activity among older cancer survivors.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32979089
 
 
|keywords=* Cancer survivorship
* Epidemiology
* Fruit and vegetable
* Gerontology
* Physical activity
|full-text-url=https://sci-hub.do/10.1007/s00520-020-05782-6
}}
{{medline-entry
|title=Leisure-time physical activity volume, intensity, and duration from mid- to late-life in U.S. subpopulations by race and sex. The Atherosclerosis Risk In Communities (ARIC) Study.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32170049
 
 
|keywords=* exercise
* healthy aging
* physical activity
* retirement
* successful aging
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7093185
}}
{{medline-entry
|title=Repressive H3K9me2 protects lifespan against the transgenerational burden of COMPASS activity in [i]C. elegans[/i].
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31815663
 
|mesh-terms=* Animals
* Caenorhabditis elegans
* Caenorhabditis elegans Proteins
* Heterochromatin
* Histone-Lysine N-Methyltransferase
* Histones
* Inheritance Patterns
* Jumonji Domain-Containing Histone Demethylases
* Longevity
* Lysine
* Methylation
* Mutation
|keywords=* C. elegans
* COMPASS
* aging
* chromatin
* chromosomes
* epigenetics
* gene expression
* genetics
* genomics
* heterochromatin
* transgenerational inheritance
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7299346
}}
{{medline-entry
|title=Influence of Anthropometrics on Step-Rate Thresholds for Moderate and Vigorous Physical Activity in Older Adults: Scientific Modeling Study.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31518246
 
 
|keywords=* aging
* cadence
* physical activity intensity
* public health
* walking
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6715008
}}
==MFI==
 
{{medline-entry
|title=The Influence of the Accelerated Aging Conditions on the Properties of Polyolefin Geogrids Used for Landfill Slope Reinforcement.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32825284
 
 
|keywords=* HDPE
* accelerated aging tests
* decrease mechanical properties
* degradation
* geosynthetics
* landfill
* polyolefin
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7564637
}}
{{medline-entry
|title=Changes in Physical Meat Traits, Protein Solubility, and the Microstructure of Different Beef Muscles during Post-Mortem Aging.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32575353
 
 
|keywords=* aging
* beef muscle
* microstructure
* myofibril fragmentation
* protein solubility
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7353465
}}
{{medline-entry
|title=Effect of a low-voltage electrical stimulation on yak meat tenderness during postmortem aging.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32583539
 
|mesh-terms=* Animals
* Cattle
* Cold Temperature
* Electric Stimulation
* Food Handling
* Food Quality
* Food Storage
* Hydrogen-Ion Concentration
* Male
* Meat
* Muscle, Skeletal
* Polysaccharides
* Postmortem Changes
* Time Factors
|keywords=* Yak
* electrical stimulation
* postmortem aging
* tenderness
|full-text-url=https://sci-hub.do/10.1111/asj.13410
}}
{{medline-entry
|title=Comparative effects of dry-aging and wet-aging on physicochemical properties and digestibility of Hanwoo beef.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31480178
 
 
|keywords=* Beef Loin
* Digestibility
* Dry Aging
* Shear Force
* Wet Aging
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7054618
}}
==MFN2==
 
{{medline-entry
|title=Thioredoxin protects mitochondrial structure, function and biogenesis in myocardial ischemia-reperfusion via redox-dependent activation of AKT-CREB- PGC1α pathway in aged mice.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/33049718
 
 
|keywords=* aging
* heart
* ischemia-reperfusion
* mitochondria
* thioredoxin
|full-text-url=https://sci-hub.do/10.18632/aging.104071
}}
{{medline-entry
|title=[[MFN2]] contributes to metabolic disorders and inflammation in the aging of rat chondrocytes and osteoarthritis.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32416221
 
 
|keywords=* Aging
* Inflammation
* MFN2
* Metabolic disorders
* Osteoarthritis
|full-text-url=https://sci-hub.do/10.1016/j.joca.2019.11.011
}}
==MFSD2A==
 
{{medline-entry
|title=Decreased Blood Level of MFSD2a as a Potential Biomarker of Alzheimer's Disease.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31861865
 
|mesh-terms=* Aged
* Alzheimer Disease
* Biomarkers
* Brain
* Fatty Acids
* Female
* Humans
* Male
* Symporters
|keywords=* Alzheimer’s disease
* MFSD2a carrier
* aging
* neurologic disorders
* omega-3 PUFA
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6981746
}}
==MGMT==
 
{{medline-entry
|title=Cytotoxic and Senolytic Effects of Methadone in Combination with Temozolomide in Glioblastoma Cells.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32977591
 
 
|keywords=* apoptosis
* cancer therapy
* drug resistance
* glioblastoma
* methadone
* senescence
* temozolomide
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7582495
}}
==MIA==
 
{{medline-entry
|title=Age, cohort, and period effects on metamemory beliefs.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31804113
 
|mesh-terms=* Aged
* Aged, 80 and over
* Aging
* Cohort Studies
* Cross-Sectional Studies
* Female
* Humans
* Longitudinal Studies
* Male
* Metacognition
* Middle Aged
 
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6901096
}}
{{medline-entry
|title=Memory Age-based Stereotype Threat: Role of Locus of Control and Anxiety.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31752597
 
|mesh-terms=* Aged
* Aging
* Anxiety
* Female
* Humans
* Internal-External Control
* Male
* Memory, Episodic
* Metacognition
* Middle Aged
* Stereotyping
 
|full-text-url=https://sci-hub.do/10.1080/0361073X.2019.1693009
}}
==MIB1==
 
{{medline-entry
|title=Immunohistochemical detection of senescence markers in human sarcomas.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31899047
 
 
|keywords=* SenTraGor
* Senescence
* p16
* p21
* sarcoma
|full-text-url=https://sci-hub.do/10.1016/j.prp.2019.152800
}}
==MIP==
 
{{medline-entry
|title=Inspiratory muscle training improves cerebrovascular and postural control responses during orthostatic stress in older women.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32705393
 
 
|keywords=* Aging
* Cardiac output
* Center-of-pressure
* Middle cerebral artery blood flow velocity
* Respiratory muscles
|full-text-url=https://sci-hub.do/10.1007/s00421-020-04441-2
}}
{{medline-entry
|title=A novel multi-marker discovery approach identifies new serum biomarkers for Parkinson's disease in older people: an EXosomes in PArkiNson Disease (EXPAND) ancillary study.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32458283
 
 
|keywords=* Aging
* Amino acids
* Cytokines
* Metabolomics
* Neurodegeneration
* Personalized medicine
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7525911
}}
{{medline-entry
|title=Sexual dimorphism of physical activity on cognitive aging: Role of immune functioning.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32387511
 
 
|keywords=* Brain aging
* Chemokines
* Cognitive aging
* Exercise
* Gender
* Inflammation
* Lifestyle
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7416443
}}
{{medline-entry
|title=Comparison of balance changes after inspiratory muscle or Otago exercise training.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31978126
 
|mesh-terms=* Aged
* Aged, 80 and over
* Aging
* Breathing Exercises
* Exercise
* Exercise Therapy
* Female
* Humans
* Male
* Maximal Respiratory Pressures
* Muscle Strength
* Physical Endurance
* Postural Balance
* Respiratory Muscles
* Respiratory Therapy
 
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6980667
}}
==MITF==
 
{{medline-entry
|title=Thymocid , a Standardized Black Cumin ([i]Nigella sativa[/i]) Seed Extract, Modulates Collagen Cross-Linking, Collagenase and Elastase Activities, and Melanogenesis in Murine B16F10 Melanoma Cells.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32707654
 
 
|keywords=* Nigella sativa
* Thymocid®
* black cumin
* collagen
* collagenase
* cosmeceutical
* elastase
* glycation
* melanogenesis
* skin aging
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7400895
}}
{{medline-entry
|title=HuRdling Senescence: HuR Breaks BRAF-Induced Senescence in Melanocytes and Supports Melanoma Growth.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32455577
 
 
|keywords=* HuR
* MITF
* Microphthalmia-associated transcription factor
* malignant melanoma
* oncogene induced senescence
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7281285
}}
==MLH1==
 
{{medline-entry
|title=The somatic mutation landscape of the human body.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31874648
 
|mesh-terms=* Age Factors
* Aging
* Humans
* Mutation
* Neoplasms
* Selection, Genetic
* Sex Factors
|keywords=* Aging
* Cancer
* Genomic instability
* Human
* Somatic evolution
* Somatic mutation
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6930685
}}
==MLKL==
 
{{medline-entry
|title=Remifentanil preconditioning protects against hypoxia-induced senescence and necroptosis in human cardiac myocytes [i]in vitro[/i].
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32584786
 
 
|keywords=* cardiomyocytes
* hypoxia
* necroptosis
* remifentanil
* senescence
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7425462
}}
==MLN==
 
{{medline-entry
|title=Age-Dependent Decrease in the Induction of Regulatory T Cells Is Associated With Decreased Expression of RALDH2 in Mesenteric Lymph Node Dendritic Cells.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32849526
 
 
|keywords=* RALDH2
* aging
* dendritic cells
* epigenetic regulation
* regulatory T cells
* retinoic acid
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7432217
}}
==MMD==
 
{{medline-entry
|title=Association between a Deficit Accumulation Frailty Index and Mobility Outcomes in Older Adults: Secondary Analysis of the Lifestyle Interventions and Independence for Elders (LIFE) Study.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/33266358
 
 
|keywords=* LIFE Study
* deficit accumulation
* disability
* frailty
* healthy aging
* mobility
* older adults
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7700674
}}
{{medline-entry
|title=Impact of Anticholinergic Medication Burden on Mobility and Falls in the Lifestyle Interventions for Elders (LIFE) Study.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32947839
 
 
|keywords=* anticholinergic burden
* falls
* mobility
* physical activity
* successful aging
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7564216
}}
{{medline-entry
|title=Impact and Lessons From the Lifestyle Interventions and Independence for Elders (LIFE) Clinical Trials of Physical Activity to Prevent Mobility Disability.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32105353
 
 
|keywords=* aging
* mobility disability
* multicenter trialphysical activity
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7187344
}}
==MME==
 
{{medline-entry
|title=Geriatric Opioid Harm Reduction: Interprofessional Student Learning Outcomes.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32284953
 
 
|keywords=* aging
* older adults
* opioid harm reduction
* overdose risk
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7139179
}}
{{medline-entry
|title=Effectiveness of local anesthetic injection in geriatric patients following operative management of proximal and diaphyseal femur fracture.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31564373
 
|mesh-terms=* Aged
* Aged, 80 and over
* Analgesics, Opioid
* Anesthetics, Local
* Delirium
* Female
* Femoral Fractures
* Fracture Fixation, Internal
* Geriatrics
* Humans
* Injections, Intra-Articular
* Intraoperative Care
* Male
* Pain Management
* Pain, Postoperative
* Retrospective Studies
|keywords=* Geriatrics
* Hip fracture
* Local anesthetic
* Narcotics
|full-text-url=https://sci-hub.do/10.1016/j.injury.2019.09.013
}}
==MMP1==
 
{{medline-entry
|title=Reacquisition of a spindle cell shape does not lead to the restoration of a youthful state in senescent human skin fibroblasts.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32533368
 
 
|keywords=* Cell shape
* Fibroblast
* Lithography
* SASP
* Senescence
|full-text-url=https://sci-hub.do/10.1007/s10522-020-09886-8
}}
{{medline-entry
|title=A novel multifunctional skin care formulation with a unique blend of antipollution, brightening and antiaging active complexes.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31584241
 
 
|keywords=* anti-wrinkle
* pigmentation
* pollution
* skin aging
* skin barrier
|full-text-url=https://sci-hub.do/10.1111/jocd.13176
}}
==MMP13==
 
{{medline-entry
|title=Aging aggravates intervertebral disc degeneration by regulating transcription factors toward chondrogenesis.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31909538
 
|mesh-terms=* Aging
* Animals
* Antigens, Differentiation
* Chondrocytes
* Chondrogenesis
* Core Binding Factor Alpha 1 Subunit
* Fetal Proteins
* Gene Expression Regulation
* Intervertebral Disc Degeneration
* Mice
* Mice, Transgenic
* Sp7 Transcription Factor
* T-Box Domain Proteins
|keywords=* Wnt/β-catenin/LRPs
* biomechanics
* genetic animal models
* osterix
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7018543
}}
==MOS==
 
{{medline-entry
|title=Effect of mannan oligosaccharides on the microbiota and productivity parameters of Litopenaeus vannamei shrimp under intensive cultivation in Ecuador.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32066764
 
|mesh-terms=* Actinobacteria
* Aeromonas
* Animal Feed
* Animals
* Aquaculture
* Bacterial Adhesion
* Ecuador
* Flavobacteriaceae
* Lactococcus
* Longevity
* Mannans
* Microbiota
* Oligosaccharides
* Penaeidae
* Proteobacteria
* Seafood
* Shewanella
* Verrucomicrobia
* Vibrio
 
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7026423
}}
{{medline-entry
|title=Predictors of health-related quality of life among older adults living with HIV in Thailand: results from the baseline and follow-up surveys.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31870166
 
 
|keywords=* Chiang Mai
* HIV and aging
* Older adults living with HIV
* Thailand
* health-related quality of life
* quality of life
|full-text-url=https://sci-hub.do/10.1080/09540121.2019.1707472
}}
{{medline-entry
|title=Comparison of health-related quality of life between the Han and Yi ethnicity elderly in the Yi autonomous areas of Yunnan Province.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31766992
 
|mesh-terms=* Activities of Daily Living
* Aged
* Aged, 80 and over
* Aging
* China
* Cross-Sectional Studies
* Ethnic Groups
* Female
* Humans
* Male
* Middle Aged
* Quality of Life
|keywords=* ADL
* Elderly
* Health-related quality of life
* IADL
* Yi ethnic minority
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6878633
}}
{{medline-entry
|title=Mannan oligosaccharide increases the growth performance, immunity and resistance capability against Vibro Parahemolyticus in juvenile abalone Haliotis discus hannai Ino.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31561025
 
|mesh-terms=* Animal Feed
* Animals
* Antioxidants
* Diet
* Dietary Supplements
* Dose-Response Relationship, Drug
* Gastropoda
* Immunity, Innate
* Longevity
* Mannans
* Oligosaccharides
* Vibrio parahaemolyticus
|keywords=* Abalone
* Antioxidation
* Bacterial challenge
* Disease resistance
* Growth
* Immunity
* Mannan oligosaccharide
|full-text-url=https://sci-hub.do/10.1016/j.fsi.2019.09.058
}}
==MPHOSPH6==
 
{{medline-entry
|title=Genome-wide Association Analysis in Humans Links Nucleotide Metabolism to Leukocyte Telomere Length.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32109421
 
|mesh-terms=* Genome-Wide Association Study
* Humans
* Leukocytes
* Nucleotides
* Telomere
|keywords=* Mendelian randomisation
* age-related disease
* biological aging
* telomere length
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7058826
}}
==MPI==
 
{{medline-entry
|title=Age-related decline of lymphatic drainage from the eye: A noninvasive in vivo photoacoustic tomography study.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32251650
 
 
|keywords=* Age-related
* Aging
* Aqueous humor
* Drainage
* Eye
* Glaucoma
* Imaging
* In vivo
* Lymph node
* Lymphatic
* Mice
* Photoacoustic tomography
* Uveoscleral
|full-text-url=https://sci-hub.do/10.1016/j.exer.2020.108029
}}
{{medline-entry
|title=Interest of the multidimensional prognostic index ([[MPI]]) as an assessment tool in hospitalized patients in geriatrics.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31570330
 
|mesh-terms=* Aged, 80 and over
* Female
* Geriatric Assessment
* Hospital Mortality
* Hospitalization
* Humans
* Length of Stay
* Male
* Patient Readmission
* Prognosis
|keywords=* elderly
* geriatrics
* hospitalization
* multidimensional prognostic index
|full-text-url=https://sci-hub.do/10.1684/pnv.2019.0823
}}
==MRE11==
 
{{medline-entry
|title=Chromosomal alterations among age-related haematopoietic clones in Japan.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32581364
 
|mesh-terms=* Aged, 80 and over
* Aging
* Alleles
* Cell Lineage
* Chromosome Aberrations
* Chromosomes, Human
* Clone Cells
* Cohort Studies
* Female
* Genetic Loci
* Genome, Human
* Hematopoiesis
* Hematopoietic Stem Cells
* Humans
* Japan
* Leukemia, Lymphocytic, Chronic, B-Cell
* Leukemia, T-Cell
* Male
* Mosaicism
* Mutation
* United Kingdom
 
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7489641
}}
==MSC==
 
{{medline-entry
|title=Rejuvenation of Senescent Endothelial Progenitor Cells by Extracellular Vesicles Derived From Mesenchymal Stromal Cells.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/33294742
 
 
|keywords=* BM, bone marrow
* CVD, cardiovascular disease
* EC, endothelial cell
* EPC, endothelial progenitor cell
* EV, extracellular vesicle
* FBS, fetal bovine serum
* MEM, minimum essential medium
* MI, myocardial infarction
* MSC, mesenchymal stromal cell
* NTA, nanotracking analysis
* PBS, phosphate-buffered saline
* TEV, tailored extracellular vesicle
* VEGF, vascular endothelial growth factor
* acellular
* angiogenesis
* extracellular vesicles
* lin− BMC, lineage negative bone marrow cell
* miR, microRNA
* qPCR, quantitative transcription polymerase chain reaction
* regeneration
* senescence
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7691285
}}
{{medline-entry
|title=Extracellular vesicles derived from bone marrow mesenchymal stem cells enhance myelin maintenance after cortical injury in aged rhesus monkeys.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/33264634
 
 
|keywords=* Aging
* Cortical injury
* Extracellular vesicles
* Monkeys
* Myelin
* Non-human primates
* Oligodendrocytes
* Stroke
* White matter
|full-text-url=https://sci-hub.do/10.1016/j.expneurol.2020.113540
}}
{{medline-entry
|title=TPP1 Enhances the Therapeutic Effects of Transplanted Aged Mesenchymal Stem Cells in Infarcted Hearts via the MRE11/AKT Pathway.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/33195247
 
 
|keywords=* DNA repair
* aging
* myocardial infarction
* stem cells therapy
* telomere
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7658181
}}
{{medline-entry
|title=Aging-Affected [[MSC]] Functions and Severity of Periodontal Tissue Destruction in a Ligature-Induced Mouse Periodontitis Model.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/33143068
 
 
|keywords=* aging
* bone resorption
* immunomodulation
* mesenchymal stem cell
* periodontitis
* tissue destruction
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7663404
}}
{{medline-entry
|title=Human placenta-derived mesenchymal stem cells stimulate ovarian function via miR-145 and bone morphogenetic protein signaling in aged rats.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/33153492
 
 
|keywords=* Aging
* Follicular development
* Hormone biosynthesis
* Primordial follicle activation
* Stem cell therapy
* miR-145
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7643421
}}
{{medline-entry
|title=Mesenchymal Stromal Cells as Critical Contributors to Tissue Regeneration.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/33102483
 
 
|keywords=* adult stem cells
* aging
* mesenchymal stromal cells (MSC)
* regenerative medicine
* stem cell niche
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7546871
}}
{{medline-entry
|title=The biology of human hair greying.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32965076
 
 
|keywords=* ageing
* endocrine
* graying
* melanin
* senescence
|full-text-url=https://sci-hub.do/10.1111/brv.12648
}}
{{medline-entry
|title=[i]Tsc1[/i] Regulates the Proliferation Capacity of Bone-Marrow Derived Mesenchymal Stem Cells.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32927859
 
 
|keywords=* TSC1
* mammalian target of rapamycin (mTOR)
* mesenchymal stem cell
* senescence
* stem cell proliferation
* tuberous sclerosis
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7565438
}}
{{medline-entry
|title=The role of mitochondrial dysfunction in mesenchymal stem cell senescence.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32803322
 
 
|keywords=* Mesenchymal stem cells
* Mitochondrial dysfunction
* Mitophagy
* Reactive oxygen species
* Senescence
|full-text-url=https://sci-hub.do/10.1007/s00441-020-03272-z
}}
{{medline-entry
|title=Metabolic syndrome increases senescence-associated micro-RNAs in extracellular vesicles derived from swine and human mesenchymal stem/stromal cells.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32787856
 
 
|keywords=* EV
* MSC
* Metabolic syndrome
* RNA-sequencing
* Senescence
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7425605
}}
{{medline-entry
|title=Functional heterogeneity of mesenchymal stem cells from natural niches to culture conditions: implications for further clinical uses.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32699947
 
 
|keywords=* Aging diseases
* Conditioned medium
* Diabetes
* Exosomes
* Extracellular vesicles
* Lupus
* Regenerative medicine
* Secretome
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7375036
}}
{{medline-entry
|title=Functional crosstalk between mTORC1/p70S6K pathway and heterochromatin organization in stress-induced senescence of [[MSC]]s.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32660632
 
 
|keywords=* Aging
* Heterochromatin
* MSC senescence
* mTORC1/p70S6K
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7359252
}}
{{medline-entry
|title=Increased cellular senescence in the murine and human stenotic kidney: Effect of mesenchymal stem cells.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32657444
 
 
|keywords=* cellular senescence
* exosomes
* kidney
* mesenchymal stem cells
* renal artery obstruction
|full-text-url=https://sci-hub.do/10.1002/jcp.29940
}}
{{medline-entry
|title=Intrinsic Type 1 Interferon (IFN1) Profile of Uncultured Human Bone Marrow CD45 CD271  Multipotential Stromal Cells (BM-[[MSC]]s): The Impact of Donor Age, Culture Expansion and IFNα and IFNβ Stimulation.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32679782
 
 
|keywords=* aging
* bone marrow
* mesenchymal stromal cells
* senescence
* type 1 interferon
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7399891
}}
{{medline-entry
|title=Facial rejuvenation using stem cell conditioned media combined with skin needling: A split-face comparative study.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32623814
 
 
|keywords=* amniotic fluid stem cells products
* dermaroller
* facial aging
* skin needling
|full-text-url=https://sci-hub.do/10.1111/jocd.13594
}}
{{medline-entry
|title=Mesenchymal Stem Cell Senescence and Rejuvenation: Current Status and Challenges.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32582691
 
 
|keywords=* autophagy
* mesenchymal stem cells
* mitochondrial
* rejuvenation
* senescence
* telomere
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7283395
}}
{{medline-entry
|title=The changing epigenetic landscape of Mesenchymal Stem/Stromal Cells during aging.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32445894
 
 
|keywords=* Aging
* DNA methylation
* Epigenetics
* Histome modifications
* MSC
* Mesenchymal Stem/Stromal Cells
* Skeleton
* miRNA
|full-text-url=https://sci-hub.do/10.1016/j.bone.2020.115440
}}
{{medline-entry
|title=Dual Role of Autophagy in Regulation of Mesenchymal Stem Cell Senescence.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32391362
 
 
|keywords=* SASP
* general autophagy
* mesenchymal stem cell
* selective autophagy
* senescence
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7193103
}}
{{medline-entry
|title=Molecular Aspects of Adipose-Derived Stromal Cell Senescence in a Long-Term Culture: A Potential Role of Inflammatory Pathways.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32314614
 
 
|keywords=* adipose-derived stromal/stem cell
* aging
* gene expression
* long-term culture
* senescence
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7586277
}}
{{medline-entry
|title=Human Obesity Induces Dysfunction and Early Senescence in Adipose Tissue-Derived Mesenchymal Stromal/Stem Cells.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32274385
 
 
|keywords=* adipose tissue
* cellular dysfunction
* cellular senescence
* mesenchymal stem cells
* obesity
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7113401
}}
{{medline-entry
|title=miR-155-5p inhibition rejuvenates aged mesenchymal stem cells and enhances cardioprotection following infarction.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32196916
 
 
|keywords=* mesenchymal stem cells
* miR-155-5p
* myocardial infarction
* rejuvenation
* senescence
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7189985
}}
{{medline-entry
|title=Mesenchymal Stem Cell Derived Extracellular Vesicles in Aging.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32154253
 
 
|keywords=* aging
* clinical translation
* extracellular vesicles
* mesenchymal stem cells
* regenerative medicine
* senescence
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7047768
}}
{{medline-entry
|title=Molecular Mechanisms Contributing to Mesenchymal Stromal Cell Aging.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32098040
 
 
|keywords=* MSC senescence
* in vitro aging
* in vivo aging
* mesenchymal stem/stromal cells (MSC)
* rejuvenating strategies
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7072652
}}
{{medline-entry
|title=Inhibition of DNA Methyltransferase by RG108 Promotes Pluripotency-Related Character of Porcine Bone Marrow Mesenchymal Stem Cells.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32125888
 
 
|keywords=* RG108
* apoptosis
* pluripotency
* porcine bone marrow mesenchymal stem cells
* senescence
|full-text-url=https://sci-hub.do/10.1089/cell.2019.0060
}}
{{medline-entry
|title=Extracellular Vesicles of Stem Cells to Prevent BRONJ.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32119600
 
 
|keywords=* bisphosphonate-associated osteonecrosis of the jaw
* cellular senescence
* exosomes
* mesenchymal stem cells
* wound healing
* zoledronic acid
|full-text-url=https://sci-hub.do/10.1177/0022034520906793
}}
{{medline-entry
|title=Ginsenoside Rg1 as an Effective Regulator of Mesenchymal Stem Cells.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32038244
 
 
|keywords=* apoptosis
* differentiation
* ginsenoside Rg1
* mesenchymal stem cells
* preclinical study
* proliferation
* senescence
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6989539
}}
{{medline-entry
|title=The Importance of Stem Cell Senescence in Regenerative Medicine.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32026416
 
 
|keywords=* Aging
* Mesenchymal stem cell
* Regenerative medicine
|full-text-url=https://sci-hub.do/10.1007/5584_2020_489
}}
{{medline-entry
|title=Control of mesenchymal stem cell biology by histone modifications.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32025282
 
 
|keywords=* Cell biology
* Cell differentiation
* Cellular senescence
* Epigenetics
* Histone modifications
* Mesenchymal stem cells
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6996187
}}
{{medline-entry
|title=Impact of mesenchymal stem cell senescence on inflammaging.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31964472
 
|mesh-terms=* Aging
* Cellular Senescence
* Cytokines
* Hematopoiesis
* Humans
* Immunomodulation
* Immunosenescence
* Inflammation
* Macrophages
* Mesenchymal Stem Cells
 
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7061209
}}
{{medline-entry
|title=Late Rescue Therapy with Cord-Derived Mesenchymal Stromal Cells for Established Lung Injury in Experimental Bronchopulmonary Dysplasia.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31918630
 
 
|keywords=* COPD
* aging
* lung
* newborn
* regenerative medicine
* stem cells
|full-text-url=https://sci-hub.do/10.1089/scd.2019.0116
}}
{{medline-entry
|title=Low-Level Radiofrequency Exposure Does Not Induce Changes in [[MSC]] Biology: An in vitro Study for the Prevention of NIR-Related Damage.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31908499
 
 
|keywords=* 169 MHz
* CFU
* senescence
* stem cell
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6927227
}}
{{medline-entry
|title=Macrophage migration inhibitory factor rejuvenates aged human mesenchymal stem cells and improves myocardial repair.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31881006
 
|mesh-terms=* Adolescent
* Aged
* Aged, 80 and over
* Aging
* Animals
* Animals, Newborn
* Cellular Senescence
* Humans
* Macrophage Migration-Inhibitory Factors
* Mesenchymal Stem Cell Transplantation
* Mesenchymal Stem Cells
* Myocardial Infarction
* Myocardium
* Myocytes, Cardiac
* Rats
* Rats, Sprague-Dawley
* Young Adult
|keywords=* macrophage migration inhibitory factor
* mesenchymal stem cells
* myocardial infarction
* rejuvenation
* senescence
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6949107
}}
{{medline-entry
|title=Influence of olive oil and its components on mesenchymal stem cell biology.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31875868
 
 
|keywords=* Aging
* Cellular differentiation
* Cellular niche
* Mediterranean diet
* Mesenchymal stem cells
* Olive oil
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6904865
}}
{{medline-entry
|title=Epigenetic Regulation of Mesenchymal Stem Cell Homeostasis.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31866188
 
 
|keywords=* aging
* epigenetics
* fate decision
* mesenchymal stem cells
* pathogenesis
* regeneration
|full-text-url=https://sci-hub.do/10.1016/j.tcb.2019.11.006
}}
{{medline-entry
|title=Mesenchymal Stem Cells: Allogeneic [[MSC]] May Be Immunosuppressive but Autologous [[MSC]] Are Dysfunctional in Lupus Patients.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31799252
 
 
|keywords=* dysfunction
* immunoregulatory
* mesenchymal stem cells
* senescence
* systemic lupus erythematosus
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6874144
}}
{{medline-entry
|title=Effects of high glucose conditions on the expansion and differentiation capabilities of mesenchymal stromal cells derived from rat endosteal niche.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31752674
 
|mesh-terms=* Adipogenesis
* Animals
* Biomarkers
* Bone Regeneration
* Bone and Bones
* Cell Differentiation
* Cell Proliferation
* Cells, Cultured
* Cellular Senescence
* Diabetes Mellitus, Type 2
* Glucose
* Hyperglycemia
* Male
* Mesenchymal Stem Cells
* Osteogenesis
* Rats, Wistar
|keywords=* Bone repair
* Cellular senescence
* Differentiation
* Hyperglycaemia
* Mesenchymal stromal cells; Endosteum
* Type II diabetes
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6873668
}}
{{medline-entry
|title=Autophagy inhibits the mesenchymal stem cell aging induced by D-galactose through ROS/JNK/p38 signalling.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31675454
 
 
|keywords=* ROS/JNK/p38 signalling
* autophagy
* mesenchymal stem cells
* senescence
|full-text-url=https://sci-hub.do/10.1111/1440-1681.13207
}}
{{medline-entry
|title=Enhancing survival, engraftment, and osteogenic potential of mesenchymal stem cells.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31692976
 
 
|keywords=* Anoikis
* Bioactive scaffolds
* Bone regeneration
* Engraftment
* Homing
* Hypoxia
* Mesenchymal stem cells
* Osteogenesis
* Preconditioning
* Senescence
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6828596
}}
{{medline-entry
|title=Mesenchymal stem cell senescence alleviates their intrinsic and seno-suppressive paracrine properties contributing to osteoarthritis development.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31644429
 
|mesh-terms=* Animals
* Cell Proliferation
* Cells, Cultured
* Cellular Senescence
* Chondrocytes
* Coculture Techniques
* Collagenases
* Etoposide
* Gene Expression Regulation
* Humans
* Inflammation
* Luciferases
* Male
* Mesenchymal Stem Cells
* Mice
* Mice, Inbred Strains
* Mice, Transgenic
* Osteoarthritis
* Paracrine Communication
|keywords=* mesenchymal stem cell
* osteoarthritis
* senescence
* tissue homeostasis
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6834426
}}
{{medline-entry
|title=Embryonic stem cell-derived extracellular vesicles enhance the therapeutic effect of mesenchymal stem cells.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31660081
 
|mesh-terms=* Animals
* Cell- and Tissue-Based Therapy
* Cellular Senescence
* Disease Models, Animal
* Embryonic Stem Cells
* Extracellular Vesicles
* Humans
* Insulin-Like Growth Factor I
* Mesenchymal Stem Cell Transplantation
* Mesenchymal Stem Cells
* Mice
* Mice, Inbred BALB C
* Phosphatidylinositol 3-Kinases
* Wounds and Injuries
|keywords=* Cellular senescence
* Embryonic stem cells
* Extracellular vesicles
* IGF1/PI3K/AKT pathway
* Mesenchymal stem cells
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6815953
}}
{{medline-entry
|title=Survival of aging CD264  and CD264  populations of human bone marrow mesenchymal stem cells is independent of colony-forming efficiency.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31612990
 
 
|keywords=* aging
* decoy TRAIL receptor 2 (CD264)
* mesenchymal stem cells
* survival
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6906265
}}
{{medline-entry
|title=Differential effects of extracellular vesicles from aging and young mesenchymal stem cells in acute lung injury.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31575829
 
|mesh-terms=* Acute Lung Injury
* Age Factors
* Animals
* Disease Models, Animal
* Extracellular Vesicles
* Mesenchymal Stem Cell Transplantation
* Mesenchymal Stem Cells
* Mice
* Treatment Outcome
|keywords=* ARDS
* acute lung injury
* aging
* extracellular vesicles
* mesenchymal stem cells
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6781978
}}
{{medline-entry
|title=Connexin43 is Dispensable for Early Stage Human Mesenchymal Stem Cell Adipogenic Differentiation But is Protective against Cell Senescence.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31514306
 
|mesh-terms=* Adipogenesis
* Cell Differentiation
* Cellular Senescence
* Connexin 43
* Gene Expression Regulation
* Humans
* Mesenchymal Stem Cells
* Time Factors
|keywords=* CRISPR-Cas9
* adipogenesis
* connexin43
* gap junctional intercellular communication
* mesenchymal stem cells
* oculodentodigital dysplasia
* senescence
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6770901
}}
{{medline-entry
|title=Maintained Properties of Aged Dental Pulp Stem Cells for Superior Periodontal Tissue Regeneration.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31440385
 
 
|keywords=* inflammation
* mesenchymal stem cells
* periodontitis
* senescence
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6675537
}}
==MTHFR==
 
{{medline-entry
|title=One-carbon metabolism supplementation improves outcome after stroke in aged male [[MTHFR]]-deficient mice.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31525435
 
|mesh-terms=* Aging
* Animals
* Brain
* Choline
* Dietary Supplements
* Male
* Methylenetetrahydrofolate Reductase (NADPH2)
* Mice
* Mice, Inbred C57BL
* Recovery of Function
* Stroke
* Tetrahydrofolates
* Vitamin B 12
|keywords=* Cerebral ischemia
* Homocysteine
* Methylenetetrahydrofolate reductase
* Neurodegeneration
* Sensorimotor cortex
* Supplementation
|full-text-url=https://sci-hub.do/10.1016/j.nbd.2019.104613
}}
==MTOR==
 
{{medline-entry
|title=The roles of [[MTOR]] and miRNAs in endothelial cell senescence.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32246301
 
 
|keywords=* Endothelium
* MTOR
* MicroRNAs
* Senescence
* Vascular aging
|full-text-url=https://sci-hub.do/10.1007/s10522-020-09876-w
}}
{{medline-entry
|title=Autophagy drives fibroblast senescence through [[MTOR]]C2 regulation.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31931659
 
 
|keywords=* Autophagy
* MTORC2
* myofibroblast
* rapamycin
* senescence
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7595590
}}
{{medline-entry
|title=The GID ubiquitin ligase complex is a regulator of AMPK activity and organismal lifespan.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31795790
 
 
|keywords=* AMPK
* GID
* autophagy
* longevity
* primary cilium
* ubiquitination
|full-text-url=https://sci-hub.do/10.1080/15548627.2019.1695399
}}
==MTR==
 
{{medline-entry
|title=Amide proton transfer-weighted magnetic resonance imaging of human brain aging at 3 Tesla.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32269932
 
 
|keywords=* Aging
* amide proton transfer imaging
* biomarkers
* chemical exchange saturation transfer (CEST)
* molecular imaging
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7136735
}}
==MUC7==
 
{{medline-entry
|title=Reduced Salivary Mucin Binding and Glycosylation in Older Adults Influences Taste in an In Vitro Cell Model.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31554163
 
|mesh-terms=* Adolescent
* Adult
* Aged
* Aging
* Cell Line
* Epithelial Cells
* Female
* Glycosylation
* Humans
* Male
* Middle Aged
* Mucins
* N-Acetylneuraminic Acid
* Plasmids
* Protein Binding
* Rheology
* Saliva
* Taste
* Young Adult
|keywords=* ageing
* mucin
* rheology
* saliva
* taste
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6835954
}}
==MYB==
 
{{medline-entry
|title=Transcriptome profiling of postharvest shoots identifies PheNAP2- and PheNAP3-promoted shoot senescence.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31595958
 
|mesh-terms=* Arabidopsis
* Arabidopsis Proteins
* Gene Expression Profiling
* Gene Expression Regulation, Plant
* Plant Leaves
* Transcriptome
|keywords=*
          Phyllostachys edulis
       
* NAC
* postharvest
* regulatory factors
* shoot senescence
|full-text-url=https://sci-hub.do/10.1093/treephys/tpz100
}}
==MYC==
 
{{medline-entry
|title=Enhanced proliferative capacity of human preadipocytes achieved by an optimized cultivating method that induces transient activity of hTERT.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32703451
 
 
|keywords=* Adipogenesis
* Adipose-derived stromal cells
* Senescence
* hTERT
* mTesR1
|full-text-url=https://sci-hub.do/10.1016/j.bbrc.2020.06.019
}}
==MYCN==
 
{{medline-entry
|title=Silencing of AURKA augments the antitumor efficacy of the AURKA inhibitor MLN8237 on neuroblastoma cells.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31920463
 
 
|keywords=* Aurora kinase A
* Cellular senescence
* MLN8237
* Neuroblastoma
* Small interfering RNA
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6947931
}}
==MYSM1==
 
{{medline-entry
|title=[[MYSM1]] Suppresses Cellular Senescence and the Aging Process to Prolong Lifespan.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/33240758
 
 
|keywords=* DNA repair
* Myb‐like, SWIRM, and MPN domains‐containing protein 1 (MYSM1)
* aging
* senescence
* senescence‐associated secretory phenotype (SASP)
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7675055
}}
==MYT1==
 
{{medline-entry
|title=ESC-sEVs Rejuvenate Aging Hippocampal NSCs by Transferring SMADs to Regulate the [[MYT1]]-Egln3-Sirt1 Axis.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/33038325
 
 
|keywords=* ESC-sEVs
* MYT1
* aging
* hippocampal NSCs
* senescence
|full-text-url=https://sci-hub.do/10.1016/j.ymthe.2020.09.037
}}
==NACA==
 
{{medline-entry
|title=Age and Sex Are Strongly Correlated to the Rate and Type of Mountain Injuries Requiring Search and Rescue Missions.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31699646
 
|mesh-terms=* Adolescent
* Adult
* Aged
* Aged, 80 and over
* Aging
* Emergency Medical Services
* Female
* Humans
* Male
* Middle Aged
* Mountaineering
* Rescue Work
* Sex Factors
* Young Adult
|keywords=* MRT
* NACA ICAR
* SAR
* injury
* mechanism
|full-text-url=https://sci-hub.do/10.1016/j.wem.2019.06.016
}}
==NAMPT==
 
{{medline-entry
|title=Over-expression of Nicotinamide phosphoribosyltransferase in mouse cells confers protective effect against oxidative and ER stress-induced premature senescence.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32533606
 
 
|keywords=* ER stress
* NAD+
* NAMPT
* oxidative stress
* premature senescence
|full-text-url=https://sci-hub.do/10.1111/gtc.12794
}}
{{medline-entry
|title=Resistance training increases muscle NAD  and NADH concentrations as well as [[NAMPT]] protein levels and global sirtuin activity in middle-aged, overweight, untrained individuals.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32369778
 
 
|keywords=* NAD +
* NADH
* aging
* muscle
* resistance training
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7288928
}}
{{medline-entry
|title=Differential Expression of Human N-Alpha-Acetyltransferase 40 (hNAA40), Nicotinamide Phosphoribosyltransferase ([[NAMPT]]) and Sirtuin-1 (SIRT-1) Pathway in Obesity and T2DM: Modulation by Metformin and Macronutrient Intake.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31920356
 
 
|keywords=* NAMPT
* T2DM
* hNAA40
* nicotinamide phosphoribosyltransferase
* obesity
* senescence
* sirtuin-1
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6938199
}}
==NDRG2==
 
{{medline-entry
|title=[[NDRG2]] Expression Correlates with Neurofibrillary Tangles and Microglial Pathology in the Ageing Brain.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31947996
 
|mesh-terms=* Aged
* Aged, 80 and over
* Aging
* Alzheimer Disease
* Antigens, CD
* Antigens, Differentiation, Myelomonocytic
* Astrocytes
* Brain
* DNA Damage
* Excitatory Amino Acid Transporter 2
* Gene Expression Regulation
* Glial Fibrillary Acidic Protein
* Glutamate-Ammonia Ligase
* Humans
* Microglia
* Neurofibrillary Tangles
* Tumor Suppressor Proteins
* tau Proteins
|keywords=* N-myc downstream regulated gene 2 (NDRG2)
* ageing brain
* astrocyte
* neurofibrillary tangles
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6982267
}}
==NDUFS8==
 
{{medline-entry
|title=Mitochondrial Complex I Mutations Predispose Drosophila to Isoflurane Neurotoxicity.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32773682
 
|mesh-terms=* Aging
* Anesthetics, Inhalation
* Animals
* Animals, Genetically Modified
* Drosophila
* Electron Transport Complex I
* Isoflurane
* Male
* Mitochondria
* Mutation
* Sevoflurane
 
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7494633
}}
==NEDD8==
 
{{medline-entry
|title=Targeting Protein Neddylation for Cancer Therapy.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31898235
 
|mesh-terms=* Animals
* Apoptosis
* Autophagy
* Cyclopentanes
* Humans
* NEDD8 Protein
* Neoplasms
* Pyrimidines
* Ubiquitin-Protein Ligases
* Ubiquitination
|keywords=* Apoptosis
* Autophagy
* Cancer target
* Inflammatory responses
* Neddylation
* Senescence
|full-text-url=https://sci-hub.do/10.1007/978-981-15-1025-0_18
}}
{{medline-entry
|title=Effective targeting of the ubiquitin-like modifier [[NEDD8]] for lung adenocarcinoma treatment.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31907687
 
 
|keywords=* NEDD8
* apoptosis
* cullin-RING ligases
* neddylation
* senescence
|full-text-url=https://sci-hub.do/10.1007/s10565-019-09503-6
}}
{{medline-entry
|title=Pevonedistat targeted therapy inhibits canine melanoma cell growth through induction of DNA re-replication and senescence.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31665821
 
 
|keywords=* DNA re-replication
* MLN4924
* NAE-inhibitor
* canine
* melanoma
* senescence
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7473101
}}
==NEO1==
 
{{medline-entry
|title=Neogenin-1 distinguishes between myeloid-biased and balanced [i]Hoxb5[/i]  mouse long-term hematopoietic stem cells.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31754028
 
|mesh-terms=* Aging
* Animals
* Female
* Hematopoietic Stem Cell Transplantation
* Hematopoietic Stem Cells
* Homeodomain Proteins
* Membrane Proteins
* Mice
* Mice, Transgenic
|keywords=* Neogenin-1
* aging
* hematopoietic stem cell
* myeloid bias
* transplantation
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6911217
}}
==NES==
 
{{medline-entry
|title=Mini-review: Aging of the neuroendocrine system: Insights from nonhuman primate models.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31891735
 
 
|keywords=* Aging
* Neuroendocrine system
* Nonhuman primate
|full-text-url=https://sci-hub.do/10.1016/j.pnpbp.2019.109854
}}
==NFKB1==
 
{{medline-entry
|title=[[NFKB1]] gene single-nucleotide polymorphisms: implications for graft-versus-host disease in allogeneic hematopoietic stem cell transplantation.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32002656
 
|mesh-terms=* Adult
* Allografts
* Disease-Free Survival
* Female
* Graft vs Host Disease
* Hematopoietic Stem Cell Transplantation
* Humans
* Male
* Middle Aged
* NF-kappa B p50 Subunit
* Pilot Projects
* Polymorphism, Single Nucleotide
* Survival Rate
|keywords=* Allogeneic hematopoietic stem cell transplantation
* Cellular senescence
* Graft-versus-host disease
* NFKB1 gene
* Senescence-associated secretory phenotype
* Single-nucleotide polymorphism
|full-text-url=https://sci-hub.do/10.1007/s00277-020-03935-5
}}
==NGF==
 
{{medline-entry
|title=Dietary fish hydrolysate supplementation containing n-3 LC-PUFAs and peptides prevents short-term memory and stress response deficits in aged mice.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32976934
 
 
|keywords=* Aging
* Anxiety-like behaviour
* Cognitive decline
* Hydrolysate
* Low molecular weight peptides
* Marine by-products
* Memory
* Navigation strategies
* Neuroinflammation
* Stress response
* n-3 Long chain polyunsaturated fatty acids (n-3 LC-PUFAs)
|full-text-url=https://sci-hub.do/10.1016/j.bbi.2020.09.022
}}
{{medline-entry
|title=Imbalance of nerve growth factor metabolism in aging women with overactive bladder syndrome.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32870355
 
 
|keywords=* Aging female
* MMP-7
* MMP-9
* Nerve growth factor
* Overactive bladder
* proNGF
|full-text-url=https://sci-hub.do/10.1007/s00345-020-03422-6
}}
{{medline-entry
|title=Parity Attenuates Intraepithelial Corneal Sensory Nerve Loss in Female Mice.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32708332
 
 
|keywords=* aging
* corneal epithelial cell proliferation
* corneal sensitivity
* corneal sensory nerves
* mouse
* parity
* pregnancy
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7404034
}}
{{medline-entry
|title=Cholinergic System and [[NGF]] Receptors: Insights from the Brain of the Short-Lived Fish [i]Nothobranchius furzeri[/i].
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32575701
 
 
|keywords=* NTRK1/NTRKA
* aging
* cholinergic system
* fish
* p75/NGFR
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7348706
}}
{{medline-entry
|title=Retrograde axonal transport of BDNF and pro[[NGF]] diminishes with age in basal forebrain cholinergic neurons.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31574357
 
|mesh-terms=* Aging
* Alzheimer Disease
* Axonal Transport
* Brain-Derived Neurotrophic Factor
* Cholinergic Neurons
* Humans
* Nerve Growth Factor
* Prosencephalon
|keywords=* Alzheimer's disease
* Axonal transport
* Basal forebrain
* Neurodegeneration
* Neurotrophins
* Trk receptors
|full-text-url=https://sci-hub.do/10.1016/j.neurobiolaging.2019.07.018
}}
{{medline-entry
|title=C-SH2 point mutation converts p85β regulatory subunit of phosphoinositide 3-kinase to an anti-aging gene.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31481652
 
|mesh-terms=* Aging
* Animals
* Blood Glucose
* Class I Phosphatidylinositol 3-Kinases
* Class Ia Phosphatidylinositol 3-Kinase
* Female
* Forkhead Transcription Factors
* Insulin
* Male
* Mice
* Mice, Inbred C57BL
* Mice, Transgenic
* Nerve Growth Factor
* Oxidative Stress
* PC12 Cells
* Platelet-Derived Growth Factor
* Point Mutation
* Proto-Oncogene Proteins c-akt
* Rats
* src Homology Domains
 
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6722097
}}
==NHS==
 
{{medline-entry
|title=Telomerase Activation to Reverse Immunosenescence in Elderly Patients With Acute Coronary Syndrome: Protocol for a Randomized Pilot Trial.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32965237
 
 
|keywords=* acute coronary syndrome
* coronary heart disease
* immunosenescence
* telomerase activator
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7542409
}}
{{medline-entry
|title=Factors associated with COVID-19-related death using OpenSAFELY.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32640463
 
|mesh-terms=* Adolescent
* Adult
* African Continental Ancestry Group
* Age Distribution
* Age Factors
* Aged
* Aged, 80 and over
* Aging
* Asian Continental Ancestry Group
* Asthma
* Betacoronavirus
* COVID-19
* Cohort Studies
* Coronavirus Infections
* Diabetes Mellitus
* Female
* Humans
* Hypertension
* Male
* Middle Aged
* Pandemics
* Pneumonia, Viral
* Proportional Hazards Models
* Risk Assessment
* SARS-CoV-2
* Sex Characteristics
* Smoking
* State Medicine
* Young Adult
 
|full-text-url=https://sci-hub.do/10.1038/s41586-020-2521-4
}}
{{medline-entry
|title=Advanced ophthalmic nurse practitioners: the potential to improve outcomes for older people with cataracts.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32548985
 
 
|keywords=* advanced practice
* gerontology
* older people
* patient outcomes
* patients
* practice development
* professional
* professional issues
* quality of life
|full-text-url=https://sci-hub.do/10.7748/nop.2020.e1229
}}
{{medline-entry
|title=Patient Satisfaction in the Spanish National Health Service: Partial Least Squares Structural Equation Modeling.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31817147
 
|mesh-terms=* Cross-Sectional Studies
* Gross Domestic Product
* Health Care Rationing
* Health Expenditures
* Humans
* Latent Class Analysis
* Least-Squares Analysis
* Life Expectancy
* Patient Safety
* Patient Satisfaction
* Spain
* State Medicine
|keywords=* National Health Service
* health policy
* partial least squares structural equation modeling (PLS-SEM)
* patient satisfaction
* quality of healthcare
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6950388
}}
{{medline-entry
|title=Heart failure with preserved ejection fraction (HFpEF) pathophysiology study (IDENTIFY-HF): does increased arterial stiffness associate with HFpEF, in addition to ageing and vascular effects of comorbidities? Rationale and design.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31748285
 
|mesh-terms=* Aged
* Aged, 80 and over
* Aging
* Biomarkers
* Comorbidity
* Diabetes Mellitus
* Echocardiography
* Exercise Tolerance
* Female
* Heart Failure
* Heart Ventricles
* Humans
* Hypertension
* Male
* Observational Studies as Topic
* Prospective Studies
* Pulse Wave Analysis
* Research Design
* Stroke Volume
* Vascular Stiffness
|keywords=* arterial stiffness
* comorbidities
* heart failure with preserved ejection fraction
* pathophysiology
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6886989
}}
{{medline-entry
|title=Challenges to concordance: theories that explain variations in patient responses.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31604052
 
|mesh-terms=* Aging
* Benchmarking
* Communication Barriers
* Community Health Nursing
* Humans
* Nurse-Patient Relations
* State Medicine
* United Kingdom
|keywords=* Concordance
* Decision making
* Person-centred care
* Psychological theories
* Self-management
|full-text-url=https://sci-hub.do/10.12968/bjcn.2019.24.10.466
}}
{{medline-entry
|title=Optimism is associated with exceptional longevity in 2 epidemiologic cohorts of men and women.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31451635
 
|mesh-terms=* Adult
* Aged
* Aged, 80 and over
* Aging
* Female
* Health Behavior
* Humans
* Logistic Models
* Longevity
* Longitudinal Studies
* Male
* Middle Aged
* Odds Ratio
|keywords=* aging
* longevity
* longitudinal study
* optimism
* psychological well-being
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6744861
}}
==NKAP==
 
{{medline-entry
|title=[[NKAP]] Regulates Senescence and Cell Death Pathways in Hematopoietic Progenitors.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31632967
 
 
|keywords=* NKAP
* apoptosis
* cyclin dependent kinase inhibitor
* hematopoiesis
* senescence
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6783958
}}
==NKX6-1==
 
{{medline-entry
|title=The dynamic methylome of islets in health and disease.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31500828
 
|mesh-terms=* Animals
* Cell Differentiation
* DNA Methylation
* Diabetes Mellitus, Type 2
* Epigenome
* Humans
* Insulin-Secreting Cells
|keywords=* Aging
* Beta cells
* DNA methylation
* Endocrine pancreas
* Epigenetics
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6768570
}}
==NLRC4==
 
{{medline-entry
|title=Hyperglycemia-induced inflamm-aging accelerates gingival senescence via [[NLRC4]] phosphorylation.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31676687
 
|mesh-terms=* Aging
* Animals
* Apoptosis Regulatory Proteins
* Blotting, Western
* Calcium-Binding Proteins
* Cellular Senescence
* Clustered Regularly Interspaced Short Palindromic Repeats
* Gingiva
* Glucose
* Hyperglycemia
* Immunohistochemistry
* Inflammation
* Interferon Regulatory Factors
* Male
* Mice
* Mice, Inbred C57BL
* RAW 264.7 Cells
* Signal Transduction
|keywords=* NLRC4
* SASP
* aging
* cellular senescence
* diabetes
* gingiva
* hyperglycemia
* inflamm-aging
* inflammasome
* inflammation
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6901307
}}
==NLRP12==
 
{{medline-entry
|title=Persistent DNA damage-induced [[NLRP12]] improves hematopoietic stem cell function.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32434992
 
 
|keywords=* Aging
* DNA repair
* Hematology
* Hematopoietic stem cells
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7259522
}}
==NLRP3==
 
{{medline-entry
|title=Innate and Adaptive Immunity in Aging and Longevity: The Foundation of Resilience.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/33269094
 
 
|keywords=* adaptive immunity
* aging
* innate immunity
* longevity
* resilience
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7673842
}}
{{medline-entry
|title=TET2-Loss-of-Function-Driven Clonal Hematopoiesis Exacerbates Experimental Insulin Resistance in Aging and Obesity.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/33113366
 
 
|keywords=* CHIP
* IL-1β
* TET2
* adipose tissue
* aging
* clonal hematopoiesis
* diabetes
* insulin resistance
* obesity
* somatic mutations
|full-text-url=https://sci-hub.do/10.1016/j.celrep.2020.108326
}}
{{medline-entry
|title=Repeated propofol exposure-induced neuronal damage and cognitive impairment in aged rats by activation of NF-κB pathway and [[NLRP3]] inflammasome.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/33115643
 
 
|keywords=* Aging
* Apoptosis
* NOD-like receptor protein 3 inflammasome
* Neuroinflammation
* Postoperative cognitive dysfunction
* Propofol
|full-text-url=https://sci-hub.do/10.1016/j.neulet.2020.135461
}}
{{medline-entry
|title=A Small Molecule Stabilizer of the MYC G4-Quadruplex Induces Endoplasmic Reticulum Stress, Senescence and Pyroptosis in Multiple Myeloma.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/33066043
 
 
|keywords=* ASC and pannexin 1
* MYC G4-quadruplex stabilizer
* NLRP3
* caspase 1
* endoplasmic reticulum stress
* gasdermin D
* inflammasome
* pyroptosis
* senescence
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7650714
}}
{{medline-entry
|title=Interleukin-1β Drives Cellular Senescence of Rat Astrocytes Induced by Oligomerized Amyloid β Peptide and Oxidative Stress.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/33013631
 
 
|keywords=* Alzheimer's disease
* amyloid β
* astrocyte
* interleukin-1β
* neuroinflammation
* senescence
* tau
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7493674
}}
{{medline-entry
|title=Mechanisms of [[NLRP3]] priming in inflammaging and age related diseases.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32883606
 
 
|keywords=* Aging
* Inflammaging
* Inflammasome
* NLRP3
* Priming
* Senescence
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7571497
}}
{{medline-entry
|title=Lamivudine Inhibits [i]Alu[/i] RNA-induced Retinal Pigment Epithelium Degeneration via Anti-inflammatory and Anti-senescence Activities.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32855848
 
 
|keywords=* NLRP3 inflammasome
* age-related macular degeneration
* lamivudine
* retinal pigment epithelium
* senescence
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7422901
}}
{{medline-entry
|title=The [[NLRP3]] Inflammasome: Metabolic Regulation and Contribution to Inflammaging.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32751530
 
 
|keywords=* NLRP3 inflammasome
* aging
* inflammation
* metabolism
* mitochondria
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7463618
}}
{{medline-entry
|title=Aging aggravated liver ischemia and reperfusion injury by promoting STING-mediated [[NLRP3]] activation in macrophages.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32666684
 
 
|keywords=* aging
* and reperfusion injury
* leucine-rich repeat containing protein 3
* liver ischemia
* macrophage immune response
* nucleotide-binding domain
* stimulator of interferon genes
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7431827
}}
{{medline-entry
|title=Targeting [[NLRP3]] Inflammasome Reduces Age-Related Experimental Alveolar Bone Loss.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32531176
 
 
|keywords=* aging
* inflammasomes
* inflammation
* macrophages
* osteoclasts
* periodontitis
|full-text-url=https://sci-hub.do/10.1177/0022034520933533
}}
{{medline-entry
|title=Korean Red Ginseng Suppresses the Expression of Oxidative Stress Response and [[NLRP3]] Inflammasome Genes in Aged C57BL/6 Mouse Ovaries.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32331214
 
 
|keywords=* Korean ginseng extract
* NLRP3 inflammasome
* aging
* ovary
* oxidative stress response
* subfertility
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7231237
}}
{{medline-entry
|title=Cepharanthine promotes the effect of dexmedetomidine on the deposition of β-amyloid in the old age of the senile dementia rat model by regulating inflammasome expression.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32337948
 
|mesh-terms=* Aging
* Animals
* Benzylisoquinolines
* Brain
* Dexmedetomidine
* Inflammasomes
* Inflammation
* Male
* Mitochondria
* Oxidative Stress
* Rats, Sprague-Dawley
* Reactive Oxygen Species
|keywords=*  dementia
*  dexmedetomidine
*  inflammasomes
*  β-amyloid
* cepharanthine
|full-text-url=https://sci-hub.do/10.5114/fn.2019.89855
}}
{{medline-entry
|title=Ginsenoside Rg1 ameliorates glomerular fibrosis during kidney aging by inhibiting NOX4 and [[NLRP3]] inflammasome activation in SAMP8 mice.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32114413
 
 
|keywords=* Ginsenoside Rg1
* Kidney aging
* NADPH oxidase 4 (NOX4)
* NLRP3 inflammasome
* Renal fibrosis
|full-text-url=https://sci-hub.do/10.1016/j.intimp.2020.106339
}}
{{medline-entry
|title=Blockade of the [[NLRP3]] inflammasome improves metabolic health and lifespan in obese mice.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31975052
 
 
|keywords=* Aging
* Autophagy
* High-fat diet
* Longevity
* NLRP3 inflammasome
* Obesity
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7206474
}}
{{medline-entry
|title=Autophagy and [[NLRP3]] inflammasome crosstalk in neuroinflammation in aged bovine brains.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31903559
 
 
|keywords=* NLRP3 inflammasome
* aging
* autophagy
* bovine
* immunosenescence
* neuroinflammation
|full-text-url=https://sci-hub.do/10.1002/jcp.29426
}}
{{medline-entry
|title=[[NLRP3]] Inflammasome Inhibition by MCC950 in Aged Mice Improves Health via Enhanced Autophagy and PPARα Activity.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31603987
 
 
|keywords=* Aging
* Autophagy
* MCC950
* NLRP3 inflammasome
* PPARα
|full-text-url=https://sci-hub.do/10.1093/gerona/glz239
}}
{{medline-entry
|title=[[NLRP3]] inflammasome suppression improves longevity and prevents cardiac aging in male mice.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31625260
 
 
|keywords=* NLRP3-inflammasome
* autophagy
* cardiac aging
* longevity
* morbidity
* mortality
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6974709
}}
{{medline-entry
|title=Reduced NRF2 expression suppresses endothelial progenitor cell function and induces senescence during aging.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31494646
 
|mesh-terms=* Aging
* Animals
* Cellular Senescence
* Endothelial Progenitor Cells
* Mice
* NF-E2-Related Factor 2
* NF-kappa B
* NLR Family, Pyrin Domain-Containing 3 Protein
* Neovascularization, Physiologic
* Oxidative Stress
|keywords=* NLRP3 inflammasome
* NRF2
* aging
* endothelial progenitor cells
* oxidative stress
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6756903
}}
{{medline-entry
|title=Effect of Aging on Taurine Transporter (TauT) Expression in the Mouse Brain Cortex.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31468381
 
|mesh-terms=* Aging
* Animals
* Brain
* Membrane Glycoproteins
* Membrane Transport Proteins
* Mice
* Mice, Inbred C57BL
* Taurine
|keywords=* Age-related diseases
* Glycine Transporter (GLYT)
* NLRP3
* Taurine Transporter (TauT)
|full-text-url=https://sci-hub.do/10.1007/978-981-13-8023-5_1
}}
==NMI==
 
{{medline-entry
|title=Age-Dependent Control of Shoulder Muscles During a Reach-and-Lift Task.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31825888
 
 
|keywords=* activity of daily living
* aging
* functional connectivity
* motor variability
* muscle fatigue
|full-text-url=https://sci-hub.do/10.1123/japa.2019-0055
}}
==NMS==
 
{{medline-entry
|title=Uncontrolled Diabetes as an Associated Factor with Dynapenia in Adults Aged 50 Years or Older: Sex Differences.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31665234
 
 
|keywords=* Aging
* Dynapenia
* Glycated hemoglobin
* Hyperglycemia
* Neuromuscular strength
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7243578
}}
==NMUR1==
 
{{medline-entry
|title=[Medicinal Chemistry Focused on Mid-sized Peptides Derived from Biomolecules].
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31685733
 
|mesh-terms=* Aging
* Chemistry, Pharmaceutical
* Drug Discovery
* Humans
* Life Style
* Molecular Targeted Therapy
* Muscle Weakness
* Muscular Atrophy
* Myostatin
* Neuropeptides
* Obesity
* Peptides
* Receptors, Neurotransmitter
* Structure-Activity Relationship
|keywords=* myostatin inhibitor
* neuromedin U receptor-selective agonist
* peptide
|full-text-url=https://sci-hub.do/10.1248/yakushi.19-00149
}}
==NNT==
 
{{medline-entry
|title=Yoga, Health-Related Quality of Life and Mental Well-Being: A Re-analysis of a Meta-analysis Using the Quality Effects Model.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31814012
 
 
|keywords=* Outcomes
* Physical activity
* Successful aging
* Systematic review
|full-text-url=https://sci-hub.do/10.1093/gerona/glz284
}}
{{medline-entry
|title=Statins After Myocardial Infarction in the Oldest: A Cohort Study in the Clinical Practice Research Datalink Database.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31647578
 
|mesh-terms=* Aged
* Aged, 80 and over
* Case-Control Studies
* Databases, Factual
* Female
* Humans
* Hydroxymethylglutaryl-CoA Reductase Inhibitors
* Male
* Myocardial Infarction
* Proportional Hazards Models
* Retrospective Studies
* Risk Assessment
* Secondary Prevention
* Stroke
|keywords=* geriatrics
* myocardial infarction
* secondary prevention
* statin
* time varying
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7028025
}}
==NOP10==
 
{{medline-entry
|title=Pseudouridylation defect due to [i]DKC1[/i] and [i][[NOP10]][/i] mutations causes nephrotic syndrome with cataracts, hearing impairment, and enterocolitis.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32554502
 
|mesh-terms=* Animals
* Cataract
* Cell Cycle Proteins
* Child
* Enterocolitis
* Female
* Genetic Predisposition to Disease
* Hearing Loss, Sensorineural
* Humans
* Longevity
* Male
* Models, Molecular
* Molecular Dynamics Simulation
* Mutation
* Nephrotic Syndrome
* Nuclear Proteins
* Pedigree
* Protein Conformation
* RNA, Ribosomal
* Ribonucleoproteins, Small Nucleolar
* Zebrafish
|keywords=* H/ACA snoRNP
* pediatrics
* pseudouridylation
* rRNA
* telomere
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7334496
}}
==NOS1==
 
{{medline-entry
|title=Prepubertal overexposure to manganese induce precocious puberty through GABA  receptor/nitric oxide pathway in immature female rats.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31711775
 
|mesh-terms=* Aging
* Animals
* Chlorides
* Endocrine Disruptors
* Female
* Gonadotropin-Releasing Hormone
* Manganese Compounds
* Neurons
* Nitric Oxide
* Ovary
* Preoptic Area
* Rats
* Rats, Sprague-Dawley
* Receptors, GABA-A
* Sexual Maturation
* Signal Transduction
* Uterus
* Weaning
|keywords=* GABA(A)R
* GnRH
* Manganese
* Nitric oxide
* Precocious puberty
|full-text-url=https://sci-hub.do/10.1016/j.ecoenv.2019.109898
}}
==NOS3==
 
{{medline-entry
|title=Application of Oxidative Stress to a Tissue-Engineered Vascular Aging Model Induces Endothelial Cell Senescence and Activation.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32455928
 
 
|keywords=* endothelial cells
* oxidative stress
* senescence
* tissue-engineered blood vessel
* vascular smooth muscle cells
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7290800
}}
==NOTCH1==
 
{{medline-entry
|title=[How Does Aging Contribute to Cancer?]
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/33130684
 
|mesh-terms=* Aged
* Aging
* Carcinogenesis
* Esophageal Neoplasms
* Humans
* Mutation
 
 
}}
{{medline-entry
|title=H19 is not hypomethylated or upregulated with age or sex in the aortic valves of mice.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31609547
 
|mesh-terms=* Aging
* Animals
* Aortic Valve
* Aortic Valve Stenosis
* Calcinosis
* DNA Methylation
* Female
* Male
* Mice
* Mice, Inbred C57BL
* RNA, Long Noncoding
* Sex Factors
* Up-Regulation
|keywords=*
H19
 
* age
* calcific aortic valve disease
* epigenetics
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6778597
}}
==NOTCH4==
 
{{medline-entry
|title=Age-dependent autophagy induction after injury promotes axon regeneration by limiting NOTCH.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31920157
 
 
|keywords=* Aging
* DLK
* LC3
* Notch signaling
* autophagy
* axon injury
* axon regeneration
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7595581
}}
==NOX4==
 
{{medline-entry
|title=Sestrin2 Attenuates Cellular Senescence by Inhibiting NADPH Oxidase 4 Expression.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/33227845
 
 
|keywords=* NOX4
* Reactive oxygen species
* Senescence
* Sestrin2
|full-text-url=https://sci-hub.do/10.4235/agmr.20.0051
}}
==NPM1==
 
{{medline-entry
|title=Flow cytometric identification and cell-line establishment of macrophages in naked mole-rats.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31784606
 
|mesh-terms=* Animals
* Cell Line
* Cell Proliferation
* Cell Separation
* Culture Media
* Flow Cytometry
* Longevity
* Macrophage Colony-Stimulating Factor
* Macrophages
* Mole Rats
* Recombinant Proteins
 
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6884578
}}
==NPR1==
 
{{medline-entry
|title=The [[NPR1]]-WRKY46-WRKY6 signaling cascade mediates probenazole/salicylic acid-elicited leaf senescence in Arabidopsis thaliana.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/33270345
 
 
|keywords=* Leaf senescence
* NPR1
* Probenazole
* Salicylic acid
* WRKY46
* WRKY6
|full-text-url=https://sci-hub.do/10.1111/jipb.13044
}}
{{medline-entry
|title=Loss of proton/calcium exchange 1 results in the activation of plant defense and accelerated senescence in Arabidopsis.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32540002
 
 
|keywords=* Early senescence
* H(+)/Ca(2+)exchanger 1
* Plant defense
* Salicylic acid
* Scopoletin
|full-text-url=https://sci-hub.do/10.1016/j.plantsci.2020.110472
}}
==NPW==
 
{{medline-entry
|title=Novel information processing at work across time is associated with cognitive change in later life: A 14-year longitudinal study.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32309980
 
|mesh-terms=* Aged
* Aging
* Cognition
* Cognitive Aging
* Cognitive Dysfunction
* Employment
* Female
* Humans
* Longitudinal Studies
* Male
* Middle Aged
* Retirement
* Time
 
|full-text-url=https://sci-hub.do/10.1037/pag0000468
}}
==NPY==
 
{{medline-entry
|title=Neuropeptide Y Enhances Progerin Clearance and Ameliorates the Senescent Phenotype of Human Hutchinson-Gilford Progeria Syndrome Cells.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32012215
 
 
|keywords=* Autophagy
* Caloric restriction mimetic
* Cellular senescence
* Human aging
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7243588
}}
{{medline-entry
|title=Effects of rikkunshito supplementation on resistance to oxidative stress and lifespan in mice.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31855319
 
|mesh-terms=* Animals
* Caloric Restriction
* Dietary Supplements
* Drugs, Chinese Herbal
* Female
* Ghrelin
* Longevity
* Male
* Mice
* Mice, Knockout
* Oxidative Stress
|keywords=* calorie restriction
* ghrelin
* longevity
* metabolism
* oxidative stress
|full-text-url=https://sci-hub.do/10.1111/ggi.13848
}}
==NRAS==
 
{{medline-entry
|title=Senescent cholangiocytes release extracellular vesicles that alter target cell phenotype via the epidermal growth factor receptor.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32558183
 
 
|keywords=* biliary epithelial cell
* cellular senescence
* extracellular vesicles
* primary sclerosing cholangitis
* senescence-associated secretory phenotype
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7669612
}}
{{medline-entry
|title=STAT3 Relays a Differential Response to Melanoma-Associated [i][[NRAS]][/i] Mutations.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31906480
 
 
|keywords=* NRAS
* STAT3
* melanoma
* mutation
* oncogene-induced senescence
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7016650
}}
{{medline-entry
|title=Cooperation of Dnmt3a R878H with Nras G12D promotes leukemogenesis in knock-in mice: a pilot study.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31703632
 
|mesh-terms=* Animals
* Apoptosis
* Carcinogenesis
* Cell Differentiation
* DNA (Cytosine-5-)-Methyltransferases
* Disease Models, Animal
* Disease Progression
* Gene Expression Regulation, Neoplastic
* Gene Knock-In Techniques
* Leukemia, Myeloid, Acute
* Longevity
* Mice
* Mice, Inbred C57BL
* Mice, Transgenic
* Monomeric GTP-Binding Proteins
* Mutation
* Phenotype
* Pilot Projects
* Proto-Oncogene Proteins c-myc
* RNA-Seq
* Transcription, Genetic
|keywords=* Acute myeloid leukemia
* DNMT3A mutation
* Myc activation
* Nras G12D
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6842226
}}
==NRL==
 
{{medline-entry
|title=Development of a cyclophosphamide stress test to predict resilience to aging in mice.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32613492
 
 
|keywords=* Aging mice
* Cyclophosphamide
* Neutrophil lymphocyte ratio
* Resilience to aging
* Stress test
* WBC count
|full-text-url=https://sci-hub.do/10.1007/s11357-020-00222-z
}}
==NRM==
 
{{medline-entry
|title=Association between Clonal Hematopoiesis and Late Nonrelapse Mortality after Autologous Hematopoietic Cell Transplantation.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31445185
 
|mesh-terms=* Adult
* Age Factors
* Aged
* Aging
* Autografts
* Female
* Hematopoiesis
* Hematopoietic Stem Cell Transplantation
* Humans
* Lymphoma, Non-Hodgkin
* Male
* Middle Aged
* Multiple Myeloma
* Retrospective Studies
|keywords=* Autologous
* Clonal hematopoiesis
* Lymphoma
* Multiple myeloma
* Nonrelapse mortality
* Survivors
* Transplantation
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7192097
}}
==NSF==
 
{{medline-entry
|title=Effects of air pollution on children from a socioecological perspective.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31727016
 
|mesh-terms=* Air Pollution
* Child Mortality
* Child, Preschool
* Environment
* Humans
* Income
* Infant
* Life Expectancy
* Retrospective Studies
* Socioeconomic Factors
* Sociological Factors
|keywords=* Deaths of children under age 5
* Electrification rates
* Income
* Inequality in life expectancy
* Natural resource depletion
* Non-solid fuel
* Outdoor and indoor air pollution
* Socioecological perspective
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6857293
}}
==NT5E==
 
{{medline-entry
|title=The [[NT5E]] gene variant strongly affects the degradation rate of inosine 5'-monophosphate under postmortem conditions in Japanese Black beef.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31401370
 
|mesh-terms=* 5'-Nucleotidase
* Animals
* Cattle
* Diaphragm
* Food Handling
* Inosine Monophosphate
* Muscle, Skeletal
* Polymorphism, Single Nucleotide
* Postmortem Changes
* Red Meat
* Taste
|keywords=* Inosine 5′-monophosphate
* Japanese Black beef
* Meat quality
* NT5E
* Postmortem aging
|full-text-url=https://sci-hub.do/10.1016/j.meatsci.2019.107893
}}
==NTHL1==
 
{{medline-entry
|title=Mitochondrial base excision repair positively correlates with longevity in the liver and heart of mammals.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31970600
 
 
|keywords=* AP endonuclease
* Aging
* DNA glycosylases
* DNA repair
* Mitochondria
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7205949
}}
==NUCB2==
 
{{medline-entry
|title=Ontogenetic Pattern Changes of Nucleobindin-2/Nesfatin-1 in the Brain and Intestinal Bulb of the Short Lived African Turquoise Killifish.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31906085
 
 
|keywords=* Nesf-1
* Nothobranchius furzeri
* aging
* brain-gut axis
* vertebrate
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7019235
}}
==OGA==
 
{{medline-entry
|title=NPGPx-Mediated Adaptation to Oxidative Stress Protects Motor Neurons from Degeneration in Aging by Directly Modulating O-GlcNAcase.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31747588
 
|mesh-terms=* Aging
* Amyotrophic Lateral Sclerosis
* Animals
* Female
* Humans
* Mice
* Mice, Mutant Strains
* Motor Neurons
* Muscle Denervation
* Oxidative Stress
* Paralysis
* beta-N-Acetylhexosaminidases
|keywords=* ALS
* NPGPx
* O-GlcNAcylation
* OGA
* aging
* motor neuron
* oxidative stress
|full-text-url=https://sci-hub.do/10.1016/j.celrep.2019.10.053
}}
==OGG1==
 
{{medline-entry
|title=Advanced Age Is Associated with Iron Dyshomeostasis and Mitochondrial DNA Damage in Human Skeletal Muscle.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31783583
 
|mesh-terms=* Adult
* Aged
* Aged, 80 and over
* Aging
* DNA, Mitochondrial
* Female
* Homeostasis
* Humans
* Inflammation
* Iron
* Male
* Mitochondria, Muscle
* Quadriceps Muscle
* Young Adult
|keywords=* ZIP
* ferritin
* hepcidin
* inflammation
* iron overload
* mitochondrial dysfunction
* mtDNA
* muscle aging
* physical performance
* transferrin
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6953082
}}
==OGT==
 
{{medline-entry
|title=ELT-2 promotes O-GlcNAc transferase [[OGT]]-1 expression to modulate Caenorhabditis elegans lifespan.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32628333
 
 
|keywords=* Caenorhabditis elegans
* GATA factor ELT-2
* OGT-1
* lifespan
|full-text-url=https://sci-hub.do/10.1002/jcb.29817
}}
{{medline-entry
|title=Neuronal O-GlcNAcylation Improves Cognitive Function in the Aged Mouse Brain.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31588002
 
|mesh-terms=* Acetylglucosamine
* Acylation
* Aging
* Animals
* Cognition
* Male
* Mice
* Mice, Knockout
* N-Acetylglucosaminyltransferases
|keywords=* O-GlcNAcylation
* OGT
* aging
* brain
* cognition
* hippocampus
* rejuvenation
* synaptic plasticity
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7199460
}}
==OSM==
 
{{medline-entry
|title=Age Differences in Sexual Minority Stress and the Importance of Friendship in Later Life.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/33143546
 
 
|keywords=* LGBT
* Sexual minorities
* cohort differences
* discrimination
* friendship aging
* internalized homonegativity
* minority stress
* outness
* social support
|full-text-url=https://sci-hub.do/10.1080/07317115.2020.1836107
}}
==OTC==
 
{{medline-entry
|title=Age and growth of stocked juvenile Shoal Bass in a tailwater: Environmental variation and accuracy of daily age estimates.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31644599
 
|mesh-terms=* Aging
* Animals
* Bass
* Ecosystem
* Environmental Monitoring
* Population Dynamics
* Reproduction
* Rivers
 
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6808449
}}
==P2RY12==
 
{{medline-entry
|title=Potential caveats of putative microglia-specific markers for assessment of age-related cerebrovascular neuroinflammation.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/33261619
 
 
|keywords=* Aging
* Brain infiltrating myeloid cells
* CD45
* Cerebral amyloid angiopathy
* Microglia
* Neuroinflammation
* P2RY12
* Stroke
* Tmem119
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7709276
}}
{{medline-entry
|title=Microglial changes in the early aging stage in a healthy retina and an experimental glaucoma model.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32958210
 
 
|keywords=* Aging
* CD68
* Glaucoma
* Iba-1
* Inflammation
* MHCII
* Microglia
* Mouse
* Ocular hypertension
* P2RY12
* Retina
|full-text-url=https://sci-hub.do/10.1016/bs.pbr.2020.05.024
}}
{{medline-entry
|title=Patterns of Expression of Purinergic Receptor [[P2RY12]], a Putative Marker for Non-Activated Microglia, in Aged and Alzheimer's Disease Brains.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31968618
 
|mesh-terms=* Aging
* Alzheimer Disease
* Biomarkers
* Brain
* Humans
* Immunohistochemistry
* Inflammation
* Macrophages
* Microglia
* Phenotype
* Plaque, Amyloid
* Receptors, Purinergic P2Y2
|keywords=* Alzheimer’s disease
* activation phenotypes
* amyloid
* immunohistochemistry
* microglia
* neuroinflammation
* temporal cortex
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7014248
}}
==P4HA2==
 
{{medline-entry
|title=Expanding the Phenotypic and Genotypic Landscape of Nonsyndromic High Myopia: A Cross-Sectional Study in 731 Chinese Patients.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31560770
 
|mesh-terms=* Adolescent
* Adult
* Aged
* Aged, 80 and over
* Aging
* Asian Continental Ancestry Group
* Axial Length, Eye
* Child
* Child, Preschool
* China
* Cross-Sectional Studies
* DNA Mutational Analysis
* Female
* Genetic Association Studies
* Genotype
* Humans
* Male
* Middle Aged
* Myopia, Degenerative
* Phenotype
* Retinal Diseases
* Vision, Low
* Young Adult
 
|full-text-url=https://sci-hub.do/10.1167/iovs.19-27921
}}
==P4HA3==
 
{{medline-entry
|title=Age-associated genes in human mammary gland drive human breast cancer progression.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32539762
 
|mesh-terms=* Adult
* Age Factors
* Aged
* Aged, 80 and over
* Animals
* Biomarkers, Tumor
* Breast
* Breast Neoplasms
* Disease Progression
* Dyneins
* Female
* Gene Expression Regulation, Neoplastic
* Heterografts
* Humans
* Mice
* Mice, Inbred NOD
* Mice, SCID
* Middle Aged
* Procollagen-Proline Dioxygenase
* Prognosis
* Survival Rate
* Tumor Cells, Cultured
|keywords=* ALX4
* Aging
* Breast cancer
* DYNLT3
* Gene expression
* P4HA3
* Relapse-free survival
* Transcriptomics
* Tumor progression
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7294649
}}
==PAH==
 
{{medline-entry
|title=Changes in light absorption by brown carbon in soot particles due to heterogeneous ozone aging in a smog chamber.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32771846
 
|mesh-terms=* Aerosols
* Biomass
* Carbon
* Ozone
* Smog
* Soot
|keywords=* Absorption Ångström exponent
* Brown carbon
* Light absorption
* Ozone aging
* Soot particles
|full-text-url=https://sci-hub.do/10.1016/j.envpol.2020.115273
}}
{{medline-entry
|title=Factors associated with pulmonary arterial hypertension ([[PAH]]) in systemic sclerosis (SSc).
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32659476
 
|mesh-terms=* Aging
* Humans
* Natriuretic Peptide, Brain
* Pulmonary Arterial Hypertension
* Risk Factors
* Scleroderma, Systemic
 
|full-text-url=https://sci-hub.do/10.1016/j.autrev.2020.102602
}}
{{medline-entry
|title=Potentially Avoidable Hospitalization among Long-Term Care Insurance Beneficiaries with Dementia.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32316707
 
 
|keywords=* Aging
* Dementia
* Long-Term Care
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7509129
}}
==PAM==
 
{{medline-entry
|title=Relationship between patient activation measurement and self-rated health in patients with chronic diseases.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/33148185
 
 
|keywords=* Aging population
* Chronic diseases
* Patient activation measurement
* Primary health care
* Self-rated health
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7643260
}}
{{medline-entry
|title=Reversal of Age-Related Neuronal Atrophy by α5-GABAA Receptor Positive Allosteric Modulation.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/33068001
 
 
|keywords=* GABA
* aging
* cognition
* neurotrophic effect
* positive allosteric modulator
|full-text-url=https://sci-hub.do/10.1093/cercor/bhaa310
}}
{{medline-entry
|title=The ratio of prematurely aging to non-prematurely aging mice cohabiting, conditions their behavior, immunity and lifespan.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32330742
 
|mesh-terms=* Aging
* Aging, Premature
* Animals
* Behavior, Animal
* Female
* Housing, Animal
* Longevity
* Lymphocytes
* Macrophages
* Mice
* Oxidative Stress
* Social Environment
|keywords=* Behavior
* Immunity
* Mean lifespan
* Prematurely aging mice
* Social environmental strategy
|full-text-url=https://sci-hub.do/10.1016/j.jneuroim.2020.577240
}}
==PAX8==
 
{{medline-entry
|title=Inadequate control of thyroid hormones sensitizes to hepatocarcinogenesis and unhealthy aging.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31518338
 
|mesh-terms=* Aging
* Animals
* Fatty Liver
* Insulin Resistance
* Liver
* Liver Neoplasms
* Male
* Mice
* Mice, Knockout
* PAX8 Transcription Factor
* Thyroid Hormones
|keywords=* glucose metabolism
* healthspan
* hyperthyroidism
* hypothyroidism
* lifespan
* thyroid hormones
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6781991
}}
==PBX1==
 
{{medline-entry
|title=Internalization of the TAT-[[PBX1]] fusion protein significantly enhances the proliferation of human hair follicle-derived mesenchymal stem cells and delays their senescence.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32436118
 
 
|keywords=* AKT
* Hair follicle mesenchymal stem cells
* PBX1
* Protein purification
* Senescence
* TAT
|full-text-url=https://sci-hub.do/10.1007/s10529-020-02909-x
}}
==PC==
 
{{medline-entry
|title=Blended home-based exercise and dietary protein in community-dwelling older adults: a cluster randomized controlled trial.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/33103379
 
 
|keywords=* Aging
* Behaviour change
* Physical functioning
* Protein
* Sarcopenia
* e-Health
|full-text-url=https://sci-hub.do/10.1002/jcsm.12634
}}
{{medline-entry
|title=Right ventricular diastolic function in aging: a head-to-head comparison between phase-contrast MRI and Doppler echocardiography.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32980983
 
 
|keywords=* Aging
* Diastolic function
* Phase-contrast MRI
* Right ventricle
|full-text-url=https://sci-hub.do/10.1007/s10554-020-02040-y
}}
{{medline-entry
|title=Pulse Width and Implantable Pulse Generator Longevity in Pallidal Deep Brain Stimulation for Dystonia: A Population-Based Comparative Effectiveness Study.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32668433
 
 
|keywords=* Deep brain stimulation
* Dystonia
* Globus pallidus internus
* Pulse generator longevity
* Pulse width
|full-text-url=https://sci-hub.do/10.1159/000508794
}}
{{medline-entry
|title=Gemcitabine plus nab-paclitaxel with initial dose reduction for older patients with advanced pancreatic cancer.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32576518
 
 
|keywords=* Adverse events
* Chemotherapy
* Gemcitabine
* Geriatrics
* Nab-paclitaxel
* Pancreatic cancer
|full-text-url=https://sci-hub.do/10.1016/j.jgo.2020.06.017
}}
{{medline-entry
|title=Protective effects of 17-β-oestradiol and phytoestrogen on age-induced oxidative stress and inhibition of surfactant synthesis in rat type II pneumocytes.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32314935
 
 
|keywords=* 17-β-Oestradiol
* aging
* oxidative stress
* phytoestrogen
* surfactant
* type ii pneumocytes
|full-text-url=https://sci-hub.do/10.1080/09637486.2020.1757044
}}
{{medline-entry
|title=Pacing During 200-m Competitive Masters Swimming.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32271289
 
|mesh-terms=* Adult
* Age Factors
* Aged
* Aged, 80 and over
* Aging
* Athletes
* Athletic Performance
* Competitive Behavior
* Female
* Humans
* Male
* Middle Aged
* Sex Factors
* Swimming
 
|full-text-url=https://sci-hub.do/10.1519/JSC.0000000000003621
}}
{{medline-entry
|title=Prostate cancer in Pennsylvania: The role of older age at diagnosis, aggressiveness, and environmental risk factors on treatment and mortality using data from the Pennsylvania Cancer Registry.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32212232
 
 
|keywords=* aging
* behavioral risk factors
* geriatric oncology
* healthy aging
* prostate cancer survivorship
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7221418
}}
{{medline-entry
|title=Extracranial versus intracranial hydro-hemodynamics during aging: a [[PC]]-MRI pilot cross-sectional study.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31931818
 
|mesh-terms=* Aged
* Aged, 80 and over
* Brain
* Cerebral Ventricles
* Cerebrospinal Fluid
* Cerebrovascular Circulation
* Cross-Sectional Studies
* Female
* Hemodynamics
* Humans
* Magnetic Resonance Imaging
* Male
* Middle Aged
|keywords=* Aging
* Arterial cerebral blood flow
* CSF flow
* PC-MRI
* Pulsatility
* Venous cerebral blood flow
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6958565
}}
{{medline-entry
|title=Age-specific health-related quality of life in disease-free long-term prostate cancer survivors versus male population controls-results from a population-based study.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31736000
 
|mesh-terms=* Adult
* Age Factors
* Aged
* Aging
* Cancer Survivors
* Case-Control Studies
* Disease-Free Survival
* Germany
* Humans
* Male
* Middle Aged
* Prostatic Neoplasms
* Quality of Life
* Surveys and Questionnaires
* Young Adult
|keywords=* Health-related quality of life
* Long-term survivor
* Population-based
* Prostate cancer
|full-text-url=https://sci-hub.do/10.1007/s00520-019-05120-5
}}
{{medline-entry
|title=Cross-Linked Polyphenol-Based Drug Nano-Self-Assemblies Engineered to Blockade Prostate Cancer Senescence.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31553876
 
|mesh-terms=* Animals
* Antineoplastic Agents
* Apoptosis
* Cell Line, Tumor
* Cellular Senescence
* Docetaxel
* Forkhead Box Protein O1
* Humans
* Male
* Mice
* Mice, Nude
* Nanostructures
* Polyphenols
* Prostatic Neoplasms
* Receptor, Transforming Growth Factor-beta Type I
* Signal Transduction
* Tannins
* Transplantation, Heterologous
|keywords=* DSAs
* apoptosis
* docetaxel
* nanoassemblies
* prostate cancer
* senescence
|full-text-url=https://sci-hub.do/10.1021/acsami.9b14738
}}
{{medline-entry
|title=An Immersive Virtual Reality Platform for Assessing Spatial Navigation Memory in Predementia Screening: Feasibility and Usability Study.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31482851
 
 
|keywords=* cognition
* dementia
* healthy aging
* memory
* virtual reality
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6751096
}}
==PCNA==
 
{{medline-entry
|title=Impairment of Pol β-related DNA Base-excision Repair Leads to Ovarian Aging in Mice.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/33223510
 
 
|keywords=* BER
* Pol β
* menopause
* oocytes
* ovarian aging
|full-text-url=https://sci-hub.do/10.18632/aging.104123
}}
{{medline-entry
|title=[Heat shock protein 90 (HSP90) in age-dependent changes in the number of fibroblasts in human skin.]
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32362082
 
|mesh-terms=* Adolescent
* Adult
* Aging
* Child
* Child, Preschool
* Dermis
* Female
* Fibroblasts
* HSP90 Heat-Shock Proteins
* Humans
* Infant
* Infant, Newborn
* Middle Aged
* Pregnancy
* Young Adult
|keywords=* HSP90
* PCNA
* aging
* fibroblasts
* skin
 
}}
{{medline-entry
|title=A Higher Frequency Administration of the Nontoxic Cycloartane-Type Triterpene Argentatin A Improved Its Anti-Tumor Activity.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32295227
 
 
|keywords=* Argentatin A
* PCNA
* antiproliferative
* antitumor
* apoptosis
* cell senescence
* colon cancer
* xenografts
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7221627
}}
{{medline-entry
|title=[Mechanosensitive protein of Hippo regulatory pathway - transcription coactivator with PZD-binding motif (TAZ) in human skin during aging.]
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32145162
 
|mesh-terms=* Adolescent
* Adult
* Aged
* Aged, 80 and over
* Aging
* Child
* Child, Preschool
* Dermis
* Female
* Fibroblasts
* Humans
* Infant
* Infant, Newborn
* Middle Aged
* Pregnancy
* Protein-Serine-Threonine Kinases
* Skin Aging
* Trans-Activators
* Young Adult
|keywords=* CD31
* PCNA
* TAZ
* aging
* blood vessels
* fibroblasts
* skin
 
}}
{{medline-entry
|title=[Mechanosensitive Yes-associated protein in human skin during aging.]
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31800177
 
|mesh-terms=* Adaptor Proteins, Signal Transducing
* Adult
* Aged
* Aged, 80 and over
* Aging
* Dermis
* Endothelial Cells
* Female
* Fibroblasts
* Humans
* Middle Aged
* Pregnancy
* Skin Aging
* Transcription Factors
|keywords=* CD31
* PCNA
* YAP
* aging
* blood vessels
* fibroblasts
* skin
 
}}
{{medline-entry
|title=[Role of mechanosensitive protein Piezo1 in human age-dependent changes in the number of fibroblasts and blood vessels in human skin.]
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31512421
 
|mesh-terms=* Adolescent
* Adult
* Aged
* Aged, 80 and over
* Blood Vessels
* Child
* Child, Preschool
* Dermis
* Female
* Fibroblasts
* Humans
* Infant
* Ion Channels
* Male
* Middle Aged
* Platelet Endothelial Cell Adhesion Molecule-1
* Pregnancy
* Proliferating Cell Nuclear Antigen
* Skin Aging
|keywords=* CD31
* PCNA
* Piezo1
* aging
* blood vessels
* fibroblasts
* skin
 
}}
==PCSK9==
 
{{medline-entry
|title=Lipoprotein removal mechanisms and aging: implications for the cardiovascular health of the elderly.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32011347
 
|mesh-terms=* Aged
* Aged, 80 and over
* Aging
* Apolipoproteins B
* Atherosclerosis
* Cardiovascular Diseases
* Cardiovascular System
* Cholesterol
* Humans
* Lipid Metabolism
* Lipoproteins
* Lipoproteins, LDL
* Risk Factors
 
|full-text-url=https://sci-hub.do/10.1097/MED.0000000000000529
}}
{{medline-entry
|title=The role of proprotein convertase subtilisin-kexin type 9 ([[PCSK9]]) in the vascular aging process - is there a link?
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31708986
 
 
|keywords=* PCSK9
* atherosclerosis
* cholesterol
* inflammation
* vascular aging
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6836637
}}
==PDCD4==
 
{{medline-entry
|title=Petal abscission in roses is associated with the activation of a truncated version of the animal [[PDCD4]] homologue, RbPCD1.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31521226
 
|mesh-terms=* Amino Acid Sequence
* Arabidopsis
* Gene Expression Regulation, Plant
* Plant Proteins
* Plants, Genetically Modified
* Programmed Cell Death 1 Receptor
* Rosa
* Sequence Alignment
* Transcription Factors
|keywords=* Ethylene
* Heat shock
* Inflorescence
* MA3 domain
* PDCD4
* Repression
* Senescence
|full-text-url=https://sci-hub.do/10.1016/j.plantsci.2019.110242
}}
==PDE2A==
 
{{medline-entry
|title=TAK-915, a phosphodiesterase 2A inhibitor, ameliorates the cognitive impairment associated with aging in rodent models.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31521738
 
|mesh-terms=* Aging
* Animals
* Brain
* Cognition
* Cognition Disorders
* Cognitive Dysfunction
* Cyclic AMP
* Cyclic GMP
* Cyclic Nucleotide Phosphodiesterases, Type 2
* Male
* Memory Disorders
* Memory, Episodic
* Phosphodiesterase Inhibitors
* Pyrazines
* Pyridines
* Rats
* Rats, Inbred F344
* Rats, Long-Evans
* Rats, Sprague-Dawley
|keywords=* Aging
* Cognition
* PDE2A
* TAK-915
|full-text-url=https://sci-hub.do/10.1016/j.bbr.2019.112192
}}
==PDE4D==
 
{{medline-entry
|title=Phosphodiesterase [[PDE4D]] Is Decreased in Frontal Cortex of Aged Rats and Positively Correlated With Working Memory Performance and Inversely Correlated With PKA Phosphorylation of Tau.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/33192469
 
 
|keywords=* Alzheimer’s disease
* PDE4D
* aging
* tau
* working memory
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7655962
}}
==PDE5A==
 
{{medline-entry
|title=Repurposing erectile dysfunction drugs tadalafil and vardenafil to increase bone mass.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32513693
 
|mesh-terms=* Aging
* Animals
* Bone Density
* Bone and Bones
* Brain
* Cell Differentiation
* Cyclic Nucleotide Phosphodiesterases, Type 5
* Drug Repositioning
* Erectile Dysfunction
* Humans
* Male
* Mice
* Middle Aged
* Models, Animal
* Models, Molecular
* Neurons
* Osteoblasts
* Osteoclasts
* Osteogenesis
* Osteoporosis
* Osteoporotic Fractures
* Phosphodiesterase 5 Inhibitors
* Primary Cell Culture
* Tadalafil
* Vardenafil Dihydrochloride
|keywords=* PDE5 inhibitor
* computational modeling
* cyclic GMP
* osteoporosis
* resorption
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7321982
}}
==PDK1==
 
{{medline-entry
|title=Inhibition of 3-phosphoinositide-dependent protein kinase 1 ([[PDK1]]) can revert cellular senescence in human dermal fibroblasts.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/33229519
 
 
|keywords=* PDK1
* cellular senescence
* network modeling
* skin aging
* systems biology
|full-text-url=https://sci-hub.do/10.1073/pnas.1920338117
}}
{{medline-entry
|title=The Impact of the PI3K/Akt Signaling Pathway in Anxiety and Working Memory in Young and Middle-Aged [[PDK1]] K465E Knock-In Mice.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32457586
 
 
|keywords=* PI3K/Akt
* RDoC
* aging
* animal model
* anxiety
* cognition
* fine tuning
* signaling pathway
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7225327
}}
==PER1==
 
{{medline-entry
|title=Quercetin, caffeic acid and resveratrol regulate circadian clock genes and aging-related genes in young and old human lung fibroblast cells.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31773385
 
|mesh-terms=* ARNTL Transcription Factors
* Age Factors
* Aging
* CLOCK Proteins
* Caffeic Acids
* Cell Line
* Circadian Clocks
* Circadian Rhythm
* Fibroblasts
* Humans
* NF-E2-Related Factor 2
* Polyphenols
* Quercetin
* Receptors, Glucocorticoid
* Resveratrol
* Sirtuin 1
|keywords=* Caffeic acid
* Circadian clock genes
* NR1D1
* NRF2
* Quercetin
* Resveratrol
|full-text-url=https://sci-hub.do/10.1007/s11033-019-05194-8
}}
==PER2==
 
{{medline-entry
|title=NAD  Controls Circadian Reprogramming through [[PER2]] Nuclear Translocation to Counter Aging.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32369735
 
|mesh-terms=* ARNTL Transcription Factors
* Age Factors
* Aging
* Animals
* CLOCK Proteins
* Circadian Clocks
* Circadian Rhythm
* Cytokines
* Female
* HEK293 Cells
* Humans
* Male
* Mice
* Mice, Inbred C57BL
* NAD
* Period Circadian Proteins
* Sirtuin 1
* Sirtuins
|keywords=* NAD(+)
* SIRT1
* aging
* circadian
* clock
* heat shock factor 1
* liver
* nicotinamide mononucleotide
* nicotinamide riboside
* transcriptomics
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7275919
}}
==PEX19==
 
{{medline-entry
|title=A genome-wide screen identifies genes that suppress the accumulation of spontaneous mutations in young and aged yeast cells.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31854076
 
|mesh-terms=* Amino Acid Transport Systems, Basic
* Cellular Senescence
* DNA Replication
* Flap Endonucleases
* Gene Ontology
* Genetic Techniques
* Genomic Instability
* Membrane Proteins
* Mutagenesis
* Mutation
* Mutation Accumulation
* Mutation Rate
* Nuclear Pore Complex Proteins
* Saccharomyces cerevisiae
* Saccharomyces cerevisiae Proteins
* Single-Strand Specific DNA and RNA Endonucleases
|keywords=* genome stability
* high-throughput screen
* mutagenesis
* mutation rate
* replicative aging
* yeast
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6996960
}}
==PEX5==
 
{{medline-entry
|title=Aging lowers [[PEX5]] levels in cortical neurons in male and female mouse brains.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32777345
 
 
|keywords=* Aging brain
* PEX5
* Peroxisomal protein
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7484460
}}
==PFAS==
 
{{medline-entry
|title=Associations between serum concentrations of perfluoroalkyl substances and DNA methylation in women exposed through drinking water: A pilot study in Ronneby, Sweden.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/33007577
 
 
|keywords=* EPIC chip
* Environmental pollutant
* Epigenetic aging
* Epigenetics
* PFAS
* Perfluoroalkyl substance
|full-text-url=https://sci-hub.do/10.1016/j.envint.2020.106148
}}
{{medline-entry
|title=Perfluorinated alkyl substances impede growth, reproduction, lipid metabolism and lifespan in Daphnia magna.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32521362
 
|mesh-terms=* Alkanesulfonic Acids
* Animals
* Caprylates
* Daphnia
* Fatty Acids
* Fluorocarbons
* Humans
* Lipid Metabolism
* Longevity
* Reproduction
|keywords=* Fatty acid
* Fecundity
* Gene expression
* PFAS toxicity
* Perfluorooctane sulfonate (PFOS)
* Perfluorooctanoic acid (PFOA)
|full-text-url=https://sci-hub.do/10.1016/j.scitotenv.2020.139682
}}
{{medline-entry
|title=The effect of weathering on per- and polyfluoroalkyl substances ([[PFAS]]s) from durable water repellent (DWR) clothing.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32062207
 
|mesh-terms=* Acrylates
* Alcohols
* Clothing
* Environmental Monitoring
* Fluorocarbon Polymers
* Fluorocarbons
* Humidity
* Models, Chemical
* Textiles
* Water
* Water Pollutants, Chemical
* Weather
|keywords=* Aging
* Durable water repellency
* Outdoor clothing
* Per- and polyfluoroalkyl substances
* Textile
* Weathering
|full-text-url=https://sci-hub.do/10.1016/j.chemosphere.2020.126100
}}
==PGC==
 
{{medline-entry
|title=The Aging Stress Response and Its Implication for AMD Pathogenesis.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/33266495
 
 
|keywords=* AMD
* DNA damage response
* PGC-1α
* SIRT1
* age-related macular degeneration
* aging
* autophagy
* insulin/IGF-1
* mitochondrial quality control
* the aging stress response
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7700335
}}
{{medline-entry
|title=Constitutive [[PGC]]-1α Overexpression in Skeletal Muscle Does Not Contribute to Exercise-Induced Neurogenesis.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/33200398
 
 
|keywords=* Aging
* Hippocampal neurogenesis
* Immunohistochemistry
* PGC-1α
* Transgenic mice
* Voluntary running
|full-text-url=https://sci-hub.do/10.1007/s12035-020-02189-6
}}
{{medline-entry
|title=Dysregulated Autophagy Mediates Sarcopenic Obesity and Its Complications via AMPK and [[PGC]]1α Signaling Pathways: Potential Involvement of Gut Dysbiosis as a Pathological Link.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32961822
 
 
|keywords=* AMPK signaling pathway
* PGC-1α signaling pathway
* aging
* autophagy
* gut axis
* inflammation
* insulin resistance
* sarcopenic obesity
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7555990
}}
{{medline-entry
|title=Resemblance and differences in dietary restriction nephroprotective mechanisms in young and old rats.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32970613
 
 
|keywords=* aging
* caloric restriction
* ischemia/reperfusion
* kidney injury
* mitochondria
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7585108
}}
{{medline-entry
|title=Acute and chronic effects of resistance training on skeletal muscle markers of mitochondrial remodeling in older adults.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32748504
 
 
|keywords=* aging
* mitochondrial dynamics
* mitochondrial function
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7399374
}}
{{medline-entry
|title=[[PGC]]-1α-mediated regulation of mitochondrial function and physiological implications.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32516539
 
 
|keywords=* aging
* exercise metabolism
* insulin resistance
* mitochondrial metabolism
* muscle metabolism
* muscle physiology
* métabolisme mitochondrial
* métabolisme musculaire
* métabolisme à l’effort
* physiologie musculaire
* résistance à l’insuline
* vieillissement
|full-text-url=https://sci-hub.do/10.1139/apnm-2020-0005
}}
{{medline-entry
|title=Targeting Mitochondrial Network Architecture in Down Syndrome and Aging.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32365535
 
 
|keywords=* Down syndrome
* PGC-1α/PPARGC1A
* aging
* mTOR
* mitochondrial dynamics
* mitochondrial function
* mitochondrial network
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7247689
}}
{{medline-entry
|title=Colchicine treatment impairs skeletal muscle mitochondrial function and insulin sensitivity in an age-specific manner.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32372536
 
 
|keywords=* ADP sensitivity
* ROS
* aging
* autophagy
|full-text-url=https://sci-hub.do/10.1096/fj.201903113RR
}}
{{medline-entry
|title=A novel dipeptide from potato protein hydrolysate augments the effects of exercise training against high-fat diet-induced damages in senescence-accelerated mouse-prone 8 by boosting pAMPK / SIRT1/ [[PGC]]-1α/ pFOXO3 pathway.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32335547
 
 
|keywords=* alcalase
* bioactive peptides
* cardio-protection
* hepato-protection
* longevity
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7202530
}}
{{medline-entry
|title=Mitochondrial nucleoid remodeling and biogenesis are regulated by the p53-p21 -PKCζ pathway in p16 -silenced cells.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32330121
 
 
|keywords=* mitochondria
* nucleoid remodeling
* p16INK4a silence
* p53-p21-PKCζ activation
* senescence
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7202532
}}
{{medline-entry
|title=[Metabolic Alteration in Aging Process: Metabolic Remodeling in White Adipose Tissue by Caloric Restriction].
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32115557
 
|mesh-terms=* Adipose Tissue, White
* Aging
* Animals
* Caloric Restriction
* Gene Expression
* Humans
* Longevity
* Mice
* Organelle Biogenesis
* Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha
* Sirtuin 3
* Sterol Regulatory Element Binding Protein 1
* Up-Regulation
|keywords=* caloric restriction (CR)
* fatty acid biosynthesis
* mitochondria
* white adipose tissue (WAT)
|full-text-url=https://sci-hub.do/10.1248/yakushi.19-00193-2
}}
{{medline-entry
|title=Kynurenine aminotransferase isoforms display fiber-type specific expression in young and old human skeletal muscle.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32068089
 
 
|keywords=* Aging
* Kynurenine aminotransferases
* Mitochondria
* Muscle fiber-type
* Skeletal muscle
|full-text-url=https://sci-hub.do/10.1016/j.exger.2020.110880
}}
{{medline-entry
|title=Ubiquinol-10 delays postovulatory oocyte aging by improving mitochondrial renewal in pigs.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31958774
 
 
|keywords=* mitochondria
* oxidative stress
* pig
* postovulatory aging
* ubiquinol-10
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7053629
}}
{{medline-entry
|title=Mitochondrial oxidative capacity and NAD  biosynthesis are reduced in human sarcopenia across ethnicities.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31862890
 
|mesh-terms=* Aged
* Aged, 80 and over
* Aging
* Biopsy
* Case-Control Studies
* Energy Metabolism
* Humans
* Jamaica
* Male
* Middle Aged
* Mitochondria
* Muscle, Skeletal
* NAD
* Oxidation-Reduction
* Oxidative Phosphorylation
* Oxidative Stress
* Proteostasis
* Sarcopenia
* Singapore
* United Kingdom
 
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6925228
}}
{{medline-entry
|title=MicroRNA-34a (miR-34a) Mediates Retinal Endothelial Cell Premature Senescence through Mitochondrial Dysfunction and Loss of Antioxidant Activities.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31443378
 
 
|keywords=* diabetic retinopathy
* miR-34a
* mitochondrial dysfunction
* vascular senescence
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6769710
}}
{{medline-entry
|title=Constitutive [[PGC]]-1α overexpression in skeletal muscle does not protect from age-dependent decline in neurogenesis.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31444397
 
|mesh-terms=* Aging
* Animals
* Blood Proteins
* Cytokines
* Female
* Hippocampus
* Male
* Mice, Inbred C57BL
* Mice, Transgenic
* Muscle, Skeletal
* Neurogenesis
* Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha
* Reproducibility of Results
 
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6707251
}}
==PGK2==
 
{{medline-entry
|title=Arsenic influences spermatogenesis by disorganizing the elongation of spermatids in adult male mice.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31472347
 
|mesh-terms=* Aging
* Animals
* Arsenic
* Cell Cycle Proteins
* DEAD-box RNA Helicases
* Gene Expression Profiling
* Male
* Mice
* RNA, Messenger
* Spermatids
* Spermatogenesis
* Spermatozoa
|keywords=* Arsenic
* Elongation of spermatids
* Male reproduction
* Spermatogenesis
|full-text-url=https://sci-hub.do/10.1016/j.chemosphere.2019.124650
}}
==PGLS==
 
{{medline-entry
|title=547 transcriptomes from 44 brain areas reveal features of the aging brain in non-human primates.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31779658
 
|mesh-terms=* Aging
* Animals
* Brain
* Carboxylic Ester Hydrolases
* Macaca mulatta
* Male
* Mice
* Transcriptome
|keywords=* Brain aging
* Multiple brain regions
* PGLS
* Rhesus macaques
* Transcriptome
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6883628
}}
==PIEZO1==
 
{{medline-entry
|title=Niche stiffness underlies the ageing of central nervous system progenitor cells.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31413369
 
|mesh-terms=* Adult Stem Cells
* Aging
* Animals
* Animals, Newborn
* Cell Count
* Central Nervous System
* Extracellular Matrix
* Female
* Humans
* Membrane Proteins
* Multipotent Stem Cells
* Oligodendroglia
* Rats
* Stem Cell Niche
 
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7025879
}}
==PINK1==
 
{{medline-entry
|title=Spermidine inhibits neurodegeneration and delays aging via the [[PINK1]]-PDR1-dependent mitophagy pathway in [i]C. elegans[/i].
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32902411
 
 
|keywords=* aging
* caenorhabditis elegans
* mitophagy
* neurodegenerative diseases
* spermidine
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7521492
}}
{{medline-entry
|title=Female mice are resilient to age-related decline of substantia nigra dopamine neuron firing parameters.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32846275
 
 
|keywords=* Aging
* Dopamine
* Electrophysiology
* Firing
* Mouse
* Substantia nigra
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7606778
}}
{{medline-entry
|title=Attenuation of epigenetic regulator SMARCA4 and ERK-ETS signaling suppresses aging-related dopaminergic degeneration.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32749068
 
 
|keywords=*
Drosophila
 
* MAPK-ERK-ETS signaling
* Parkinson's disease
* SMARCA4/Brahma
* aging
* neurodegeneration
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7511865
}}
{{medline-entry
|title=SIRT1 alleviates high-magnitude compression-induced senescence in nucleus pulposus cells via [[PINK1]]-dependent mitophagy.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32687063
 
 
|keywords=* SIRT1
* compression
* mitophagy
* nucleus pulposus
* senescence
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7485741
}}
{{medline-entry
|title=Synergistic action of propolis with levodopa in the management of Parkinsonism in Drosophila melanogaster.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32386191
 
 
|keywords=* Drosophila melanogaster
* Levodopa induced dyskinesia
* PINK1B9
 
* Parkinsonism
* Parkinson’s disease
* aging
* antioxidant activity
* catalase
* climbing index
* lifespan
* oxidative stress
* propolis
|full-text-url=https://sci-hub.do/10.1515/jcim-2019-0136
}}
{{medline-entry
|title=Compression-induced senescence of nucleus pulposus cells by promoting mitophagy activation via the [[PINK1]]/PARKIN pathway.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32281308
 
 
|keywords=* PARKIN pathway
* PINK1
* compression
* intervertebral disc
* mitophagy
* senescence
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7214186
}}
{{medline-entry
|title=Doxorubicin-induced normal breast epithelial cellular aging and its related breast cancer growth through mitochondrial autophagy and oxidative stress mitigated by ginsenoside Rh2.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32100342
 
|mesh-terms=* Autophagy
* Breast Neoplasms
* Cell Culture Techniques
* Cell Line, Tumor
* Doxorubicin
* Drugs, Chinese Herbal
* Female
* Ginsenosides
* Humans
* Mitochondria
* Oxidative Stress
|keywords=* ROS
* cancer growth
* cellular senescence
* chemotherapy
* ginsenoside Rh2
* mitophagy
|full-text-url=https://sci-hub.do/10.1002/ptr.6636
}}
{{medline-entry
|title=Mitochondrial DNA heteroplasmy rises in substantial nigra of aged [[PINK1]] KO mice.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31727366
 
|mesh-terms=* Aging
* Animals
* Brain
* DNA Copy Number Variations
* DNA, Mitochondrial
* Gene Frequency
* Mice, Knockout
* Mutation Rate
* Protein Kinases
* Substantia Nigra
|keywords=* PINK1
* Parkin
* Parkinson’s disease
* mtDNA heteroplasmy
|full-text-url=https://sci-hub.do/10.1016/j.bbrc.2019.10.112
}}
==PIP==
 
{{medline-entry
|title=Potentially inappropriate prescriptions according to explicit and implicit criteria in patients with multimorbidity and polypharmacy. MULTIPAP: A cross-sectional study.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32785232
 
|mesh-terms=* Aged
* Cross-Sectional Studies
* Female
* Geriatrics
* Humans
* Inappropriate Prescribing
* Independent Living
* Male
* Multimorbidity
* Polypharmacy
* Potentially Inappropriate Medication List
* Prevalence
* Primary Health Care
* Risk
* Spain
 
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7423095
}}
{{medline-entry
|title=Quality of prescribing predicts hospitalisation in octogenarians: life and living in advanced age: a cohort study in New Zealand (LiLACS NZ).
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31856733
 
|mesh-terms=* Aged
* Aged, 80 and over
* Aging
* Cohort Studies
* Drug Prescriptions
* Female
* Follow-Up Studies
* Forecasting
* Hospitalization
* Humans
* Inappropriate Prescribing
* Longitudinal Studies
* Male
* New Zealand
* Patient Discharge
* Potentially Inappropriate Medication List
|keywords=* Appropriate prescribing
* Ethnicity
* Longitudinal study
* Older people
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6921419
}}
==PLIN2==
 
{{medline-entry
|title=Cardiac overexpression of perilipin 2 induces atrial steatosis, connexin 43 remodeling, and atrial fibrillation in aged mice.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31661297
 
|mesh-terms=* Animals
* Atrial Fibrillation
* Connexin 43
* Gene Knock-In Techniques
* Heart Atria
* Isolated Heart Preparation
* Lipid Droplets
* Mice
* Mice, Transgenic
* Microscopy, Electron
* Myocytes, Cardiac
* Perilipin-2
* Sterol Esterase
* Triglycerides
* Voltage-Sensitive Dye Imaging
|keywords=* aging
* cardiac steatosis
* gap junction
* lipid droplets
* lipotoxic arrhythmia
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6957375
}}
==PLK4==
 
{{medline-entry
|title=A novel lncRNA [[PLK4]] up-regulated by talazoparib represses hepatocellular carcinoma progression by promoting YAP-mediated cell senescence.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32243714
 
 
|keywords=* Yes-associated protein
* cellular senescence
* hepatocellular carcinoma
* polo-like kinase 4 associated lncRNA
* talazoparib
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7205816
}}
{{medline-entry
|title=Differential expression of AURKA/[[PLK4]] in quiescence and senescence of osteosarcoma U2OS cells.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32200684
 
 
|keywords=* AURKA
* Osteosarcoma
* PLK4
* quiescence
* senescence
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7217361
}}
==PLN==
 
{{medline-entry
|title=An analysis of the costs of treating aged patients in a large clinical hospital in Poland under the pressure of recent demographic trends.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32399116
 
 
|keywords=* Polish health care system
* ageing society
* gerontology
* healthcare
* hospital costs
* length and cost of hospitalization
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7212232
}}
==PML==
 
{{medline-entry
|title=Progressive multifocal leukoencephalopathy in dimethyl fumarate-treated multiple sclerosis patients.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32808554
 
 
|keywords=* Multiple sclerosis
* PML
* fumarate
* immunosenescence
* lymphopenia
|full-text-url=https://sci-hub.do/10.1177/1352458520949158
}}
{{medline-entry
|title=[[PML]]2-mediated thread-like nuclear bodies mark late senescence in Hutchinson-Gilford progeria syndrome.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32351002
 
 
|keywords=* HGPS
* PML2
* senescence
* thread-like PML NBs
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7294779
}}
==PNN==
 
{{medline-entry
|title=Hyaluronan degradation and release of a hyaluronan-aggrecan complex from perineuronal nets in the aged mouse brain.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/33253804
 
 
|keywords=* Brain aging
* Chondroitin sulfate proteoglycan
* Extracellular matrix
* Hyaluronan
* Perineuronal net
|full-text-url=https://sci-hub.do/10.1016/j.bbagen.2020.129804
}}
==PNP==
 
{{medline-entry
|title=Temporal Discrimination Thresholds and Proprioceptive Performance: Impact of Age and Nerve Conduction.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31803012
 
 
|keywords=* TDMT
* aging
* kinesthesia
* pointing task
* position estimation
* somatosensory temporal discrimination
* temporal discrimination threshold
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6877661
}}
==POLL==
 
{{medline-entry
|title=Temporal trends in loss of life expectancy after a cancer diagnosis among the Australian population.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32062407
 
|mesh-terms=* Aged
* Aged, 80 and over
* Australia
* Cancer Survivors
* Cohort Studies
* Female
* Humans
* Life Expectancy
* Male
* Middle Aged
* Neoplasms
|keywords=* Australia
* Cancer
* Life expectancy
* Survival
* Temporal
|full-text-url=https://sci-hub.do/10.1016/j.canep.2020.101686
}}
==POLR3A==
 
{{medline-entry
|title=Nucleolar disruption, activation of P53 and premature senescence in [[POLR3A]]-mutated Wiedemann-Rautenstrauch syndrome fibroblasts.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32976914
 
 
|keywords=* Cell senescence
* DNA damage
* Nucleolus
* Nucleus
* RNA polymerase III subunit A (POLR3A)
* Wiedemann-Rautenstrauch syndrome
|full-text-url=https://sci-hub.do/10.1016/j.mad.2020.111360
}}
==POMC==
 
{{medline-entry
|title=Gpr17 deficiency in [[POMC]] neurons ameliorates the metabolic derangements caused by long-term high-fat diet feeding.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31611548
 
|mesh-terms=* Aging
* Animals
* Body Weight
* Brain
* Diet, High-Fat
* Energy Metabolism
* Female
* Homeostasis
* Insulin Resistance
* Liver
* Male
* Mice
* Mice, Knockout
* Motor Activity
* Nerve Tissue Proteins
* Neurons
* Pro-Opiomelanocortin
* Receptors, G-Protein-Coupled
* Sex Factors
 
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6791877
}}
==POR==
 
{{medline-entry
|title=The Ventricular System Enlarges Abnormally in the Seventies, Earlier in Men, and First in the Frontal Horn: A Study Based on More Than 3,000 Scans.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31749695
 
 
|keywords=* Evans’ index
* aging
* brain
* enlargement
* hydrocephalus
* normal pressure
* ventricular system
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6848156
}}
==POT1==
 
{{medline-entry
|title=MiR-185 targets [[POT1]] to induce telomere dysfunction and cellular senescence.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32687062
 
 
|keywords=* aging
* cellular senescence
* miR-185
* protection of telomere 1
* telomere dysfunction
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7425516
}}
{{medline-entry
|title=Seryl tRNA synthetase cooperates with [[POT1]] to regulate telomere length and cellular senescence.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31815007
 
 
|keywords=* Cancer genomics
* Senescence
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6882858
}}
==POU5F1==
 
{{medline-entry
|title=Cell quality evaluation with gene expression analysis of spheroids (3D) and adherent (2D) adipose stem cells.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/33148459
 
 
|keywords=* ALDH family
* Adipose stem cells
* Aging
* Shelterin complex
* Spheroid
* Telomere length
|full-text-url=https://sci-hub.do/10.1016/j.gene.2020.145269
}}
==PPID==
 
{{medline-entry
|title=Relationships of inflamm-aging with circulating nutrient levels, body composition, age, and pituitary pars intermedia dysfunction in a senior horse population.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32058159
 
|mesh-terms=* Aging
* Animals
* Body Composition
* Cytokines
* Female
* Folic Acid
* Horse Diseases
* Horses
* Inflammation
* Male
* Nutrients
* Pituitary Diseases
* Pituitary Gland, Intermediate
|keywords=* Horse
* Inflamm-aging
* Muscle
* Nutrition
* Pituitary pars intermedia dysfunction
* Senior
|full-text-url=https://sci-hub.do/10.1016/j.vetimm.2020.110013
}}
==PRDM8==
 
{{medline-entry
|title=[[PRDM8]] reveals aberrant DNA methylation in aging syndromes and is relevant for hematopoietic and neuronal differentiation.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32819411
 
 
|keywords=* Aging
* Aplastic anemia
* DNA methylation
* Dyskeratosis congenita
* Epigenetic clock
* Hematopoietic differentiation
* Neuronal differentiation
* PRDM8
* Telomere
* iPSC
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7439574
}}
==PRDX1==
 
{{medline-entry
|title=Active vitamin D supplementation alleviates initiation and progression of nonalcoholic fatty liver disease by repressing the p53 pathway.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31756344
 
|mesh-terms=* Animals
* Apoptosis
* Cellular Senescence
* Diet, High-Fat
* Dietary Supplements
* Fas Ligand Protein
* Hepatocytes
* Metabolic Networks and Pathways
* Mice, Knockout
* Non-alcoholic Fatty Liver Disease
* Oxidative Stress
* Proteins
* Steroid Hydroxylases
* Tumor Suppressor Protein p53
* Vitamin D
* fas Receptor
|keywords=* Active vitamin D
* Apoptosis
* Nonalcoholic fatty liver disease
* Oxidative stress
* Senescence
* p53 pathway
|full-text-url=https://sci-hub.do/10.1016/j.lfs.2019.117086
}}
==PRDX3==
 
{{medline-entry
|title=Proteomic analyses reveal that ginsenoside Rg3([i]S[/i]) partially reverses cellular senescence in human dermal fibroblasts by inducing peroxiredoxin.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32148389
 
 
|keywords=* Ginsenoside Rg3(S)
* Human dermal fibroblast
* Label-free quantitative proteomics
* Restoration
* Senescence
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7033328
}}
==PRDX6==
 
{{medline-entry
|title=Dentate Gyrus Peroxiredoxin 6 Levels Discriminate Aged Unimpaired From Impaired Rats in a Spatial Memory Task.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31417400
 
 
|keywords=* PRDX6
* aging
* dentate gyrus
* hippocampus
* hole-board
* peroxiredoxin
* proteomics
* spatial memory
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6684764
}}
==PRKDC==
 
{{medline-entry
|title=DNA-PKcs modulates progenitor cell proliferation and fibroblast senescence in idiopathic pulmonary fibrosis.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31464599
 
|mesh-terms=* Animals
* Cell Line
* Cell Proliferation
* Cellular Senescence
* Chromones
* DNA Damage
* DNA Repair
* DNA-Activated Protein Kinase
* DNA-Binding Proteins
* Female
* Fibroblasts
* Humans
* Idiopathic Pulmonary Fibrosis
* Lung
* Mesenchymal Stem Cells
* Mice
* Mice, SCID
* Morpholines
|keywords=* DNA-PKcs
* IPF
* Mesenchymal progenitor cells
* Senescence
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6716822
}}
==PRL==
 
{{medline-entry
|title=Mechanism of [[PRL]]2 phosphatase-mediated PTEN degradation and tumorigenesis.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32788364
 
|mesh-terms=* Animals
* Carcinogenesis
* Female
* HEK293 Cells
* Humans
* Immediate-Early Proteins
* Longevity
* Male
* Mice, Inbred C57BL
* Mice, Knockout
* Nedd4 Ubiquitin Protein Ligases
* PTEN Phosphohydrolase
* Protein Tyrosine Phosphatases
* Proto-Oncogene Proteins c-akt
* Ubiquitination
|keywords=* NEDD4
* PRL2
* PTEN
* protein tyrosine phosphatases
* ubiquitination
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7456095
}}
{{medline-entry
|title=Prolactin mitigates deficiencies of retinal function associated with aging.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31698287
 
|mesh-terms=* Aging
* Animals
* Apoptosis
* Electroretinography
* Mice, Inbred C57BL
* Nerve Growth Factors
* Neuroglia
* Prolactin
* Retina
* Retinal Degeneration
|keywords=* Aging
* Apoptosis
* Glia activation
* Hormone
* Mesotopic and photopic electroretinogram
* Retina
|full-text-url=https://sci-hub.do/10.1016/j.neurobiolaging.2019.10.002
}}
{{medline-entry
|title=A Spontaneous Aggressive ERα+ Mammary Tumor Model Is Driven by Kras Activation.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31390566
 
|mesh-terms=* Aging
* Animals
* Carcinogenesis
* Datasets as Topic
* Estrogen Receptor alpha
* Female
* Gene Expression Profiling
* Humans
* Mammary Neoplasms, Experimental
* Mice
* Prolactin
* Proto-Oncogene Proteins p21(ras)
* Rats
* Signal Transduction
* Transgenes
|keywords=* ER+ breast cancer
* Ras mutations
* breast cancer
* genomic analyses
* mouse models
* prolactin
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6713291
}}
==PRNP==
 
{{medline-entry
|title=Spontaneous generation of prions and transmissible PrP amyloid in a humanised transgenic mouse model of A117V GSS.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32516343
 
|mesh-terms=* Adult
* Aging
* Amyloid
* Animals
* Brain
* Codon
* Heterozygote
* Homozygote
* Humans
* Mice, Transgenic
* Middle Aged
* Prions
 
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7282622
}}
==PROC==
 
{{medline-entry
|title=Does midlife aging impact women's sleep duration, continuity, and timing?: A longitudinal analysis from the Study of Women's Health Across the Nation.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31633180
 
 
|keywords=* actigraphy
* aging
* sleep duration
* sleep in women
* sleep quality
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7157190
}}
==PSD==
 
{{medline-entry
|title=Quantitative Immunoblotting Analyses Reveal that the Abundance of Actin, Tubulin, Synaptophysin and EEA1 Proteins is Altered in the Brains of Aged Mice.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32652177
 
 
|keywords=* aging
* brain
* cortex
* glutamate receptor
* synapse
* vesicle
|full-text-url=https://sci-hub.do/10.1016/j.neuroscience.2020.06.044
}}
{{medline-entry
|title=Exercise Attenuates Brain Aging by Rescuing Down-Regulated Wnt/β-Catenin Signaling in Aged Rats.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32390823
 
 
|keywords=* DKK-1
* Wnt
* brain aging
* exercise
* β-catenin
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7192222
}}
{{medline-entry
|title=Concurrent nicotine exposure to prenatal alcohol consumption alters the hippocampal and cortical neurotoxicity.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31938742
 
 
|keywords=* Aging
* Mitochondrial function
* Neuroscience
* Oxidative stress
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6953639
}}
==PSEN2==
 
{{medline-entry
|title=Accelerated brain aging towards transcriptional inversion in a zebrafish model of the K115fs mutation of human [[PSEN2]].
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31978074
 
|mesh-terms=* Aging
* Alternative Splicing
* Alzheimer Disease
* Animals
* Animals, Genetically Modified
* Brain
* Datasets as Topic
* Disease Models, Animal
* Down-Regulation
* Female
* Frameshift Mutation
* Gene Editing
* Gene Regulatory Networks
* Heterozygote
* Humans
* Microglia
* Presenilin-1
* Presenilin-2
* Protein Isoforms
* Proteomics
* RNA-Seq
* Up-Regulation
* Zebrafish
* Zebrafish Proteins
 
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6980398
}}
{{medline-entry
|title=Loss of presenilin 2 age-dependently alters susceptibility to acute seizures and kindling acquisition.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31862541
 
 
|keywords=* Aging
* Alzheimer's
* Carbamazepine
* Corneal kindling
* Diazepam
* Epilepsy
* Lamotrigine
* Levetiracetam
* Presenilin
* Seizures
* Valproic acid
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7462087
}}
==PSMD11==
 
{{medline-entry
|title=The effect and mechanism of 19S proteasome [[PSMD11]]/Rpn6 subunit in D-Galactose induced mimetic aging models.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32450067
 
 
|keywords=* Age-related hearing loss
* Aging
* D-galactose
* PSMD11
* Proteasome
|full-text-url=https://sci-hub.do/10.1016/j.yexcr.2020.112093
}}
==PSMD14==
 
{{medline-entry
|title=Upregulation of deubiquitinase [[PSMD14]] in lung adenocarcinoma (LUAD) and its prognostic significance.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32226511
 
 
|keywords=* PMSD14
* apoptosis
* deubiquitinating enzyme
* lung adenocarcinoma
* prognosis
* senescence
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7086243
}}
==PTEN==
 
{{medline-entry
|title=Senescence Reprogramming by TIMP1 Deficiency Promotes Prostate Cancer Metastasis.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/33186519
 
 
|keywords=* FGF1
* GDF-15
* MMPs
* PTEN
* TIMP1
* docetaxel
* prostate cancer metastasis
* senescence
* senescence-associated secretory phenotype (SASP)
* senolytic therapy
|full-text-url=https://sci-hub.do/10.1016/j.ccell.2020.10.012
}}
{{medline-entry
|title=Alterations in Mitochondrial Dynamic-related Genes in the Peripheral Blood of Alzheimer's Disease Patients.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/33023448
 
 
|keywords=* Alzheimer's disease
* DRP1
* FIS1
* aging
* mitochondrial dynamics
* mitophagy
|full-text-url=https://sci-hub.do/10.2174/1567205017666201006162538
}}
{{medline-entry
|title=Human ESC-sEVs alleviate age-related bone loss by rejuvenating senescent bone marrow-derived mesenchymal stem cells.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32944188
 
 
|keywords=* Extracellular vesicle
* bone loss
* bone marrow MSCs
* cellular senescence
* embryonic stem cells
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7480439
}}
{{medline-entry
|title=The precursor of PI(3,4,5)P  alleviates aging by activating daf-18(Pten) and independent of daf-16.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32901024
 
|mesh-terms=* Aging
* Animals
* Animals, Genetically Modified
* Caenorhabditis elegans
* Caenorhabditis elegans Proteins
* Cell Line, Tumor
* Female
* Forkhead Transcription Factors
* Inositol
* Locomotion
* Longevity
* Metabolic Networks and Pathways
* Metabolomics
* Mice
* Mitophagy
* Models, Animal
* PTEN Phosphohydrolase
* Phosphatidylinositol Phosphates
* Protein Kinases
* Protein-Serine-Threonine Kinases
* RNA Interference
* RNA-Seq
 
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7479145
}}
{{medline-entry
|title=Quercetin alleviates kidney fibrosis by reducing renal tubular epithelial cell senescence through the SIRT1/PINK1/mitophagy axis.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32702447
 
|mesh-terms=* Animals
* Antioxidants
* Cell Line
* Cellular Senescence
* Epithelium
* Fibrosis
* Flow Cytometry
* Kidney
* Kidney Tubules, Proximal
* Mitophagy
* Protein Kinases
* Quercetin
* Rats
* Sirtuin 1
|keywords=* Fibrosis
* Mitochondria
* Mitophagy
* Quercetin
* Senescence
|full-text-url=https://sci-hub.do/10.1016/j.lfs.2020.118116
}}
{{medline-entry
|title=Downregulation of [[PTEN]] mediates bleomycin-induced premature senescence in lung cancer cells by suppressing autophagy.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32436415
 
 
|keywords=* PI3K/Akt/mTOR pathway
* PTEN
* autophagy
* bleomycin
* cancer cell
* premature senescence
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7287201
}}
{{medline-entry
|title=miR-155 inhibits mitophagy through suppression of BAG5, a partner protein of PINK1.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31948758
 
|mesh-terms=* Adaptor Proteins, Signal Transducing
* Aging
* Animals
* Cell Line
* Cells, Cultured
* Down-Regulation
* Humans
* Male
* Mesenchymal Stem Cells
* Mice, Inbred C57BL
* MicroRNAs
* Mitophagy
* Protein Interaction Maps
* Protein Kinases
* Up-Regulation
|keywords=* Aging
* Bone marrow MSCs
* Mitophagy
* miR-155
|full-text-url=https://sci-hub.do/10.1016/j.bbrc.2020.01.022
}}
{{medline-entry
|title=Environmental Exposures and Asthma Development: Autophagy, Mitophagy, and Cellular Senescence.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31849968
 
|mesh-terms=* Airway Remodeling
* Asthma
* Autophagy
* Cellular Senescence
* Disease Susceptibility
* Environmental Exposure
* Humans
* Mitophagy
* Oxidative Stress
* Respiratory Mucosa
|keywords=* asthma
* autophagy
* mitophagy
* oxidative stress
* senescence
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6896909
}}
{{medline-entry
|title=[[PTEN]] loss regulates alveolar epithelial cell senescence in pulmonary fibrosis depending on Akt activation.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31527305
 
|mesh-terms=* Aging
* Cellular Senescence
* Epithelial Cells
* Humans
* Idiopathic Pulmonary Fibrosis
* PTEN Phosphohydrolase
* Proto-Oncogene Proteins c-akt
* Pulmonary Alveoli
* Respiratory Mucosa
|keywords=* aging
* cellular senescence
* phosphatase and tension homolog deleted on chromosome ten
* protein kinase B
* pulmonary fibrosis
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6781970
}}
==PTH==
 
{{medline-entry
|title=Vitamin D Receptor Polymorphisms in Sex-Frailty Paradox.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32899460
 
 
|keywords=* aging
* frailty
* vitamin D
* vitamin D receptor
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7551757
}}
{{medline-entry
|title=Parathyroid hormone ameliorates temporomandibular joint osteoarthritic-like changes related to age.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32154622
 
|mesh-terms=* Aging
* Animals
* Calcium-Regulating Hormones and Agents
* Cells, Cultured
* Disease Models, Animal
* Male
* Mice
* Mice, Inbred C57BL
* Osteoarthritis
* Osteogenesis
* Parathyroid Hormone
* Temporomandibular Joint
|keywords=* cellular senescence
* cyclin-dependent kinase inhibitor P16INK4A
* marrow mesenchymal stem cells
* osteoarthritis
* temporomandibular joint disorders
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7162802
}}
==PTP4A3==
 
{{medline-entry
|title=Transcriptional and Functional Changes of the Human Microvasculature during Physiological Aging and Alzheimer Disease.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32402127
 
 
|keywords=* 3D microvascular network
* blood-brain barrier
* endothelium
* human serum
* vascular aging
|full-text-url=https://sci-hub.do/10.1002/adbi.202000044
}}
==PTPN11==
 
{{medline-entry
|title=Fine mapping genetic variants associated with age at puberty and sow fertility using SowPro90 genotyping array.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32888012
 
 
|keywords=*
          SowPro90
       
* Bayes interval mapping
* custom genotyping array
* gilts
* puberty
* reproductive longevity
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7568434
}}
==PTTG1==
 
{{medline-entry
|title=[Down-regulated [[PTTG1]] expression promotes the senescence of human prostate cancer LNCaP-AI].
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32216239
 
|mesh-terms=* Cell Line, Tumor
* Cell Proliferation
* Humans
* Male
* Prostatic Neoplasms, Castration-Resistant
* RNA, Small Interfering
* Securin
* beta-Galactosidase
|keywords=*  LNCaP-AI cell
 
*  castration-resistant prostate cancer
*  cellular senescence
*  pituitary tumor-transforming gene-1
* prostate cancer
 
}}
==PTX3==
 
{{medline-entry
|title=Aerobic Training Down-Regulates Pentraxin 3 and Pentraxin 3/Toll-Like Receptor 4 Ratio, Irrespective of Oxidative Stress Response, in Elderly Subjects.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32012711
 
 
|keywords=* aging
* endurance training
* exercise
* inflammation
* oxidative stress
* pentraxin 3
* toll-like receptor 4
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7070734
}}
{{medline-entry
|title=Sex Differences in the Association Between Pentraxin 3 and Cognitive Decline: The Cardiovascular Health Study.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31808814
 
 
|keywords=* Biomarkers
* Cognitive aging
* Inflammation
* Sex differences
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7357589
}}
==PUM1==
 
{{medline-entry
|title=Identification of reference genes for RT-qPCR data normalisation in aging studies.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31562345
 
|mesh-terms=* Aging
* Algorithms
* Gene Expression Profiling
* Genes, Essential
* Humans
* Real-Time Polymerase Chain Reaction
* Software
 
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6764958
}}
==RACK1==
 
{{medline-entry
|title=Invariable stoichiometry of ribosomal proteins in mouse brain tissues with aging.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31636180
 
|mesh-terms=* Aging
* Animals
* Brain
* Female
* Gene Expression Regulation, Developmental
* Male
* Mice
* Proteomics
* Ribosomal Proteins
|keywords=* aging
* mass spectrometry
* neuronal tissues
* ribosome
* translation
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6842600
}}
==RAF1==
 
{{medline-entry
|title=Circular [i]ANRIL[/i] isoforms switch from repressors to activators of [i]p15/CDKN2B[/i] expression during [[RAF1]] oncogene-induced senescence.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32862732
 
 
|keywords=*  INK4 locus
* Non-coding RNAs
* Polycomb proteins
* circular RNAs
* gene expression regulation
* oncogene-induced senescence
|full-text-url=https://sci-hub.do/10.1080/15476286.2020.1812910
}}
==RAG1==
 
{{medline-entry
|title=T cell senescence accelerates Angiotensin II-induced target organ damage.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32049355
 
 
|keywords=* T cell
* angiotensin II
* cardiorenal dysfunction
* senescence
|full-text-url=https://sci-hub.do/10.1093/cvr/cvaa032
}}
==RAG2==
 
{{medline-entry
|title=Phosphate Transporter Profiles in Murine and Human Thymi Identify Thymocytes at Distinct Stages of Differentiation.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32793218
 
 
|keywords=* aging
* glucose transporters
* human
* metabolism
* mice
* phosphate transporters
* thymus
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7387685
}}
==RAN==
 
{{medline-entry
|title=Rapid automatized naming ([[RAN]]): effects of aging on a predictor of reading skill.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32799742
 
 
|keywords=* Aging
* RAN
* individual differences
* naming
* reading
|full-text-url=https://sci-hub.do/10.1080/13825585.2020.1806987
}}
==RELB==
 
{{medline-entry
|title=New control of the senescence barrier in breast cancer.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32158912
 
 
|keywords=* CEBPB
* Cellular senescence
* PAK4
* RELB
* p21-activated kinase
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7051141
}}
==REST==
 
{{medline-entry
|title=[Brain and Neuronal Aging: Aged Brain Controls via Gene Expression Fidelity and Master Regulatory Factors].
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32115559
 
|mesh-terms=* Aged
* Aged, 80 and over
* Aging
* Animals
* Brain
* Gene Expression
* Gene Expression Regulation, Developmental
* Humans
* Neurodegenerative Diseases
* Protein Biosynthesis
* Repressor Proteins
* Ribosomes
|keywords=* aging
* brain
* gene expression
* neurodegeneration
* ribosome
* translational fidelity
|full-text-url=https://sci-hub.do/10.1248/yakushi.19-00193-4
}}
{{medline-entry
|title=Effect of 9 - PAHSA on cognitive dysfunction in diabetic mice and its possible mechanism.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32014256
 
|mesh-terms=* Aging
* Animals
* Behavior, Animal
* Blood Glucose
* Body Weight
* Brain
* Brain-Derived Neurotrophic Factor
* Cognitive Dysfunction
* Diabetes Mellitus, Experimental
* Exploratory Behavior
* Male
* Memory Disorders
* Mice
* Palmitic Acid
* Repressor Proteins
* Social Behavior
* Spatial Memory
* Stearic Acids
|keywords=* 9-PAHSA
* BDNF
* Diabetes mellitus
* REST
|full-text-url=https://sci-hub.do/10.1016/j.bbrc.2020.01.071
}}
{{medline-entry
|title=Increased [[REST]] to Optimize Life Span?
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31762373
 
|mesh-terms=* Animals
* Caenorhabditis elegans
* Caenorhabditis elegans Proteins
* Homeostasis
* Longevity
* Repressor Proteins
* Signal Transduction
|keywords=* life span
* neuronal activity
* neurotoxicity
|full-text-url=https://sci-hub.do/10.1089/rej.2019.2287
}}
==RET==
 
{{medline-entry
|title=Effects of resistance exercise training on redox homeostasis in older adults. A systematic review and meta-analysis.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32615210
 
 
|keywords=* Aging
* Antioxidants
* Exercise
* Oxidative stress
* Resistance exercise training
|full-text-url=https://sci-hub.do/10.1016/j.exger.2020.111012
}}
{{medline-entry
|title=Effects of an 8-week resistance training intervention on plantar flexor muscle quality and functional capacity in older women: A randomised controlled trial.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32562747
 
 
|keywords=* Aging
* Muscle echo intensity
* Muscle quality
* Physical function
* Resistance training
|full-text-url=https://sci-hub.do/10.1016/j.exger.2020.111003
}}
{{medline-entry
|title=Resistance exercise training promotes fiber type-specific myonuclear adaptations in older adults.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32134710
 
 
|keywords=* aging
* hypertrophy
* myonuclear domain
* skeletal muscle
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7191507
}}
{{medline-entry
|title=Low skeletal muscle capillarization limits muscle adaptation to resistance exercise training in older adults.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31518665
 
|mesh-terms=* Adaptation, Physiological
* Aged
* Capillaries
* Citrate (si)-Synthase
* Exercise
* Female
* Humans
* Hypertrophy
* Male
* Muscle Fibers, Skeletal
* Muscle Proteins
* Muscle, Skeletal
* Resistance Training
* Sarcopenia
* Ubiquitin-Protein Ligases
|keywords=* Aging
* Capillary
* Fiber cross-sectional area
* Muscle hypertrophy
* Muscle protein synthesis
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6904952
}}
==REV1==
 
{{medline-entry
|title=[[REV1]] inhibitor JH-RE-06 enhances tumor cell response to chemotherapy by triggering senescence hallmarks.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/33168727
 
 
|keywords=* Rev1
* cell death
* chemotherapy
* senescence
* translesion synthesis
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7682577
}}
==RHEB==
 
{{medline-entry
|title=The Rheb-TORC1 signaling axis functions as a developmental checkpoint.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32041790
 
|mesh-terms=* Animals
* Animals, Genetically Modified
* Autophagy
* CRISPR-Cas Systems
* Caenorhabditis elegans
* Caenorhabditis elegans Proteins
* Life Cycle Stages
* Longevity
* Mechanistic Target of Rapamycin Complex 1
* Phosphotransferases (Alcohol Group Acceptor)
* RNA Interference
* RNA, Small Interfering
* Ras Homolog Enriched in Brain Protein
* Signal Transduction
|keywords=* MTOR
* MTORC1
* Ral
* RalGAP
* TSC
* Tuberous sclerosis complex
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7063671
}}
==RHO==
 
{{medline-entry
|title=Conditional reprogramming: next generation cell culture.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32963937
 
 
|keywords=* 3T3-J2 fibroblast
* AACR, American Association for Cancer Research
* ACC, adenoid cystic carcinoma
* AR, androgen receptor
* CFTR, cystic fibrosis transmembrane conductance regulators
* CR, conditional reprogramming
* CYPs, cytochrome P450 enzymes
* Conditional reprogramming
* DCIS, ductal carcinoma in situ
* ECM, extracellular matrix
* ESC, embryonic stem cell
* HCMI, human cancer model initiatives
* HGF, hepatocyte growth factor
* HNE, human nasal epithelial
* HPV, human papillomaviruses
* ICD, intracellular domain
* LECs, limbal epithelial cells
* NCI, National Cancer Institute
* NGFR, nerve growth factor receptor
* NSCLC, non-small cell lung cancer
* NSG, NOD/SCID/gamma
* PDAC, pancreatic ductal adenocarcinoma
* PDX, patient derived xenograft
* PP2A, protein phosphatase 2A
* RB, retinoblastoma-associated protein
* ROCK
* ROCK, Rho kinase
* SV40, simian virus 40 large tumor antigen
* Senescence
* UVB, ultraviolet radiation b
* Y-27632
* dECM, decellularized extracellular matrix
* hASC, human adipose stem cells
* hTERT, human telomerase reverse transcriptase
* iPSCs, induction of pluripotent stem cells
* ΔNP63α, N-terminal truncated form of P63α
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7488362
}}
{{medline-entry
|title=SARS-CoV-2 receptor ACE2 and TMPRSS2 are primarily expressed in bronchial transient secretory cells.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32246845
 
|mesh-terms=* Adult
* Aging
* Angiotensin-Converting Enzyme 2
* Bronchi
* COVID-19
* Cells, Cultured
* Chronic Disease
* Coronavirus Infections
* Epithelial Cells
* Female
* Gene Expression
* Gene Expression Profiling
* Germany
* Goblet Cells
* Humans
* Lung
* Male
* Middle Aged
* Pandemics
* Peptidyl-Dipeptidase A
* Pneumonia, Viral
* Reference Standards
* Sequence Analysis, RNA
* Serine Endopeptidases
* Sex Characteristics
* Single-Cell Analysis
* Smoking
* Tissue Banks
|keywords=*
FURIN
 
* COVID-19
* Human Cell Atlas
* epithelial differentiation
* respiratory tract
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7232010
}}
==RICTOR==
 
{{medline-entry
|title=Endothelial senescence-associated secretory phenotype (SASP) is regulated by Makorin-1 ubiquitin E3 ligase.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31476350
 
|mesh-terms=* Cellular Senescence
* Endothelial Cells
* Human Umbilical Vein Endothelial Cells
* Humans
* MicroRNAs
* Nerve Tissue Proteins
* Phosphorylation
* Protein Binding
* Rapamycin-Insensitive Companion of mTOR Protein
* Ribonucleoproteins
* Telomeric Repeat Binding Protein 2
* Ubiquitin-Protein Ligases
|keywords=* Inflammation
* MKRN1
* Senescence
* Senescence-associated secretory phenotype (SASP)
* Telomeric repeat binding factor 2-interacting protein (TERF2IP)
* p90RSK
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7059097
}}
==RIF1==
 
{{medline-entry
|title=53BP1 Enforces Distinct Pre- and Post-resection Blocks on Homologous Recombination.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31653568
 
|mesh-terms=* Aging
* Animals
* BRCA1 Protein
* DNA Breaks, Double-Stranded
* DNA Damage
* Genomic Instability
* Homologous Recombination
* Mice
* Mutation
* Poly(ADP-ribose) Polymerase Inhibitors
* Rad51 Recombinase
* Tumor Suppressor p53-Binding Protein 1
* Ubiquitin-Protein Ligases
|keywords=* 53BP1
* BRCA1
* PARPi
* aging
* cancer
* homologous recombination
* resection
* shieldin
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6993210
}}
==RIPK1==
 
{{medline-entry
|title=Casein kinase 1G2 suppresses necroptosis-promoted testis aging by inhibiting receptor-interacting kinase 3.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/33206046
 
 
|keywords=* aging
* cell biology
* mouse
* necroptosis
* protein kinase
* reproductivity
* testis
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7673785
}}
{{medline-entry
|title=Crucial role of the terminal complement complex in chondrocyte death and hypertrophy after cartilage trauma.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31981738
 
 
|keywords=* Aurintricarboxylic acid
* Cartilage trauma
* Hypertrophy
* Regulated cell death
* Senescence
* Terminal complement complex
|full-text-url=https://sci-hub.do/10.1016/j.joca.2020.01.004
}}
==RIPK3==
 
{{medline-entry
|title=Metformin mediates cardioprotection against aging-induced ischemic necroptosis.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31944526
 
|mesh-terms=* Aging
* Animals
* Autophagy
* GTPase-Activating Proteins
* Humans
* Hypoglycemic Agents
* Imidazoles
* Indoles
* Male
* Metformin
* Mice
* Mice, Inbred C57BL
* Mice, Knockout
* Myocardium
* Myocytes, Cardiac
* Necroptosis
* Protein Binding
* RNA, Small Interfering
* Receptor-Interacting Protein Serine-Threonine Kinases
* Reperfusion Injury
* Sequestosome-1 Protein
|keywords=* aging
* autophagy defect
* cardioprotection
* ischemia/reperfusion injury
* metformin
* myocardial necroptosis
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6996959
}}
==RNF10==
 
{{medline-entry
|title=Reduced RING finger protein 10 expression in macrophages is associated with aging-related inflammation.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/33249776
 
 
|keywords=* E3 ubiquitin ligase
* RNF10
* immunosenescence
* inflammation
* macrophages
|full-text-url=https://sci-hub.do/10.1002/2211-5463.13049
}}
==RNF13==
 
{{medline-entry
|title=The effects of environmental stressors on candidate aging associated genes.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32344118
 
 
|keywords=* Aging
* Candidate genes
* Environmental factors
* Epigenetic
* Hypo/hyper methylated (methylation)
|full-text-url=https://sci-hub.do/10.1016/j.exger.2020.110952
}}
==ROCK2==
 
{{medline-entry
|title=Physical exercise increases ROCK activity in the skeletal muscle of middle-aged rats.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32032622
 
 
|keywords=* Aging
* Insulin resistance
* Physical exercise
* Rho-kinase (ROCK)
|full-text-url=https://sci-hub.do/10.1016/j.mad.2020.111213
}}
==RPE==
 
{{medline-entry
|title=Transcriptomic Profiling of Human Pluripotent Stem Cell-derived Retinal Pigment Epithelium over Time.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/33307245
 
 
|keywords=* Aging
* Human embryonic stem cell
* Human pluripotent stem cell
* Retinal pigment epithelium
* Single-cell RNA sequencing
|full-text-url=https://sci-hub.do/10.1016/j.gpb.2020.08.002
}}
{{medline-entry
|title=Relationship between Oxygen Uptake, Heart Rate, and Perceived Effort in an Aquatic Incremental Test in Older Women.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/33187067
 
 
|keywords=* aging
* cardiorespiratory
* maximum test
* rate of perceived exertion
* water aerobics
* water-based exercises
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7697777
}}
{{medline-entry
|title=Photoreceptor Degeneration in Homozygous Male Per2  Mice During Aging.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/33135952
 
 
|keywords=* Per2luc
* aging
* circadian
* mice
* photoreceptors
* retinal pigment epithelium
|full-text-url=https://sci-hub.do/10.1177/0748730420965285
}}
{{medline-entry
|title=An In-Vitro Cell Model of Intracellular Protein Aggregation Provides Insights into [[RPE]] Stress Associated with Retinopathy.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32932802
 
 
|keywords=* AMD
* RPE
* aging
* autofluorescence
* autophagy
* diet
* lysosomes
* oxidized POS
* proteolysis
* retina
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7555953
}}
{{medline-entry
|title=Short-Term Effect of Self-Selected Training Intensity on Ambulatory Blood Pressure in Hypertensive Older Women: A Randomized Controlled Trial.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32904579
 
 
|keywords=* aging
* exercise
* hypertension
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7457386
}}
{{medline-entry
|title=Correlation between brain volume and retinal photoreceptor outer segment volume in normal aging and neurodegenerative diseases.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32881874
 
|mesh-terms=* Aged
* Aging
* Brain
* Female
* Humans
* Linear Models
* Magnetic Resonance Imaging
* Male
* Middle Aged
* Multivariate Analysis
* Neurodegenerative Diseases
* Organ Size
* Retinal Photoreceptor Cell Outer Segment
* Retinal Pigment Epithelium
* Tomography, Optical Coherence
 
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7470418
}}
{{medline-entry
|title=Oxidative stress in the retina and retinal pigment epithelium ([[RPE]]): Role of aging, and DJ-1.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32826201
 
 
|keywords=* Aging
* DJ-1
* Oxidative stress
* Retina
* Retinal pigment epithelium
* Sodium iodate
|full-text-url=https://sci-hub.do/10.1016/j.redox.2020.101623
}}
{{medline-entry
|title=Direct-Coupled Electroretinogram (DC-ERG) for Recording the Light-Evoked Electrical Responses of the Mouse Retinal Pigment Epithelium.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32744516
 
|mesh-terms=* Aging
* Animals
* Electrophysiological Phenomena
* Electroretinography
* Light
* Mice
* Retinal Pigment Epithelium
 
|full-text-url=https://sci-hub.do/10.3791/61491
}}
{{medline-entry
|title=High-density lipoproteins are a potential therapeutic target for age-related macular degeneration.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32737203
 
 
|keywords=* age-related macular degeneration
* aging
* apolipoprotein
* complement
* complement factor H
* glycosaminoglycan
* heparan sulfate
* heparan sulfate proteoglycans
* high-density lipoprotein (HDL)
* lipoprotein
* oligosaccharide
* retinal degeneration
* retinal pigmented epithelium
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7521644
}}
{{medline-entry
|title=MTOR-initiated metabolic switch and degeneration in the retinal pigment epithelium.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32721041
 
 
|keywords=* AMD
* Mtor
* aging
* lipid
* metabolism
|full-text-url=https://sci-hub.do/10.1096/fj.202000612R
}}
{{medline-entry
|title=[i]Lactobacillus paracasei[/i] KW3110 Suppresses Inflammatory Stress-Induced Premature Cellular Senescence of Human Retinal Pigment Epithelium Cells and Reduces Ocular Disorders in Healthy Humans.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32708511
 
 
|keywords=* cellular senescence
* eye fatigue
* inflammation
* lactic acid bacteria
* probiotics
* retina
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7403967
}}
{{medline-entry
|title=Retinal pigment epithelium transcriptome analysis in chronic smoking reveals a suppressed innate immune response and activation of differentiation pathways.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32634473
 
 
|keywords=* Age-related macular degeneration
* Aging
* Differentiation
* Innate immunity
* RNA sequencing
* Smoking
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7434665
}}
{{medline-entry
|title=Differences in Intraretinal Pigment Migration Across Inherited Retinal Dystrophies.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32442431
 
|mesh-terms=* Adult
* Aging
* Cell Movement
* Female
* Follow-Up Studies
* Humans
* Male
* Ophthalmoscopy
* Retinal Dystrophies
* Retinal Pigment Epithelium
* Retrospective Studies
* Slit Lamp Microscopy
* Tomography, Optical Coherence
 
|full-text-url=https://sci-hub.do/10.1016/j.ajo.2020.05.010
}}
{{medline-entry
|title=Exosomal MiRNA Transfer between Retinal Microglia and [[RPE]].
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32429541
 
 
|keywords=* RPE
* aging
* exosome
* inflammation
* microglia
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7279010
}}
{{medline-entry
|title=Functionally validated imaging endpoints in the Alabama study on early age-related macular degeneration 2 (ALSTAR2): design and methods.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32429847
 
 
|keywords=* Age-related macular degeneration
* Aging
* Cones
* Dark adaptation
* Light sensitivity
* Macula
* Quantitative autofluorescence
* Retina
* Rods
* Spectral domain optical coherence tomography
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7236516
}}
{{medline-entry
|title=Mechanisms of mitochondrial dysfunction and their impact on age-related macular degeneration.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32298788
 
 
|keywords=* Age-related macular degeneration
* Aggregation
* Aging
* Autophagy
* Clearance
* Degeneration
* Mitochondria
* Mitophagy
* Retina
* Retinal pigment epithelium
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7650008
}}
{{medline-entry
|title=CSF1R blockade induces macrophage ablation and results in mouse choroidal vascular atrophy and [[RPE]] disorganization.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32234210
 
 
|keywords=* RPE disorganization
* aging
* choroid
* choroidal macrophage
* choroidal vasculature
* immunology
* inflammation
* mouse
* neuroscience
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7156269
}}
{{medline-entry
|title=Extracellular microparticles exacerbate oxidative damage to retinal pigment epithelial cells.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32173468
 
 
|keywords=* Extracellular vesicles
* Oxidative stress
* Phagocytosis
* RPE cell Dysfunction
* RPE cell-Derived microparticles (RMPs)
* Retinal pigment epithelial cell (RPE)
* Senescence
|full-text-url=https://sci-hub.do/10.1016/j.yexcr.2020.111957
}}
{{medline-entry
|title=Water-based continuous and interval training in older women: Cardiorespiratory and neuromuscular outcomes (WATER study).
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32145293
 
 
|keywords=* Aerobic capacity
* Aerobic training
* Aging
* Aquatic exercise
* Interval exercise
* Muscle echo intensity
* Muscle strength
* Muscle thickness
|full-text-url=https://sci-hub.do/10.1016/j.exger.2020.110914
}}
{{medline-entry
|title=Retrieval Practice Improves Recollection-Based Memory Over a Seven-Day Period in Younger and Older Adults.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32038382
 
 
|keywords=* aging
* recollection and familiarity
* retrieval practice
* temporal dynamics
* testing effect
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6990689
}}
{{medline-entry
|title=A Comparison of Heart Rate Training Load and Perceptual Effort Between Masters and Young Cyclists
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32000141
 
|mesh-terms=* Adult
* Aging
* Bicycling
* Heart Rate
* High-Intensity Interval Training
* Humans
* Middle Aged
* Perception
* Physical Exertion
|keywords=* age
* endurance training
* high-intensity interval training
* older athlete
|full-text-url=https://sci-hub.do/10.1123/ijspp.2019-0413
}}
{{medline-entry
|title=Retinal Pigment Epithelial Cells: The Unveiled Component in the Etiology of Prpf Splicing Factor-Associated Retinitis Pigmentosa.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31884616
 
|mesh-terms=* Animals
* Circadian Rhythm
* Epithelial Cells
* Eye Proteins
* Humans
* Mice
* Phagocytosis
* Photoreceptor Cells, Vertebrate
* RNA Splicing Factors
* Retinal Pigment Epithelium
* Retinitis Pigmentosa
|keywords=* Aging
* Cellular stress
* Circadian rhythm
* Metabolism
* PRPF
* Phagocytosis
* Retinal pigment epithelium
* Retinitis pigmentosa
* Splicing factors
|full-text-url=https://sci-hub.do/10.1007/978-3-030-27378-1_37
}}
{{medline-entry
|title=AMPK May Play an Important Role in the Retinal Metabolic Ecosystem.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31884657
 
|mesh-terms=* AMP-Activated Protein Kinases
* Animals
* DNA Damage
* DNA, Mitochondrial
* Disease Models, Animal
* Gene Dosage
* Metformin
* Mice
* Oxidative Stress
* Retina
* Retinal Degeneration
* Retinitis Pigmentosa
|keywords=* AMPK
* Adenosine monophosphate-activated protein kinase
* Aging
* Glycolysis
* Metabolism
* Neuroprotection
* Retina
|full-text-url=https://sci-hub.do/10.1007/978-3-030-27378-1_78
}}
{{medline-entry
|title=Stem cell-derived retinal pigment epithelium from patients with age-related macular degeneration exhibit reduced metabolism and matrix interactions.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31840941
 
 
|keywords=* Bruch's membrane
* age-related macular degeneration
* aging
* induced pluripotent stem cells
* nonenzymatic nitration
* retinal pigment epithelium
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7031648
}}
{{medline-entry
|title=Elovanoids counteract oligomeric β-amyloid-induced gene expression and protect photoreceptors.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31712409
 
|mesh-terms=* Amyloid beta-Peptides
* Animals
* Apoptosis
* Autophagy
* Cells, Cultured
* Docosahexaenoic Acids
* Extracellular Matrix
* Fatty Acids, Omega-3
* Gene Expression Regulation
* Humans
* Male
* Mice, Inbred C57BL
* Mice, Transgenic
* Photoreceptor Cells
* Retina
* Retinal Pigment Epithelium
* Young Adult
|keywords=* SASP
* age-related macular degeneration
* p16
* retinal pigment epithelial cells
* senescence gene program
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6883841
}}
{{medline-entry
|title=Genetic LAMP2 deficiency accelerates the age-associated formation of basal laminar deposits in the retina.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31699817
 
|mesh-terms=* Aging
* Animals
* Basement Membrane
* Bruch Membrane
* Exocytosis
* Humans
* Lysosomal-Associated Membrane Protein 2
* Lysosomes
* Macular Degeneration
* Mice
* Mice, Knockout
* Phagocytosis
* Retina
* Retinal Pigment Epithelium
|keywords=* LAMP2
* aging
* lysosome
* retinal degeneration
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6876195
}}
{{medline-entry
|title=Age, lipofuscin and melanin oxidation affect fundus near-infrared autofluorescence.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31648994
 
|mesh-terms=* Age Factors
* Animals
* Biomarkers
* Choroid
* Disease Models, Animal
* Female
* Fluorescein Angiography
* Fundus Oculi
* Humans
* Lipofuscin
* Macular Degeneration
* Male
* Melanins
* Melanosomes
* Mice
* Mice, Knockout
* Optical Imaging
* Oxidation-Reduction
* Oxidative Stress
* Protein Transport
* Retinal Pigment Epithelium
* Tomography, Optical Coherence
|keywords=* Aging
* Lipofuscin
* Melanin
* Melanolipofuscin
* Oxidative stress
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6838394
}}
{{medline-entry
|title=Relevance of working memory for reinforcement learning in older adults varies with timescale of learning.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31544587
 
 
|keywords=* Aging
* computational modeling
* individual differences
* reinforcement learning
* working memory
|full-text-url=https://sci-hub.do/10.1080/13825585.2019.1664389
}}
{{medline-entry
|title=Expression and Function of Mas-Related G Protein-Coupled Receptor D and Its Ligand Alamandine in Retina.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31392515
 
|mesh-terms=* Aging
* Angiotensin II
* Animals
* Cells, Cultured
* Electroretinography
* Humans
* Ligands
* Lipopolysaccharides
* Mice, Inbred C57BL
* Mice, Knockout
* Oligopeptides
* Rats
* Reactive Oxygen Species
* Receptors, G-Protein-Coupled
* Retina
|keywords=* Alamandine
* Angiotensin-(1–7)
* Mas-related G protein-coupled receptor D
* Rennin-angiotensin system
* Retina
|full-text-url=https://sci-hub.do/10.1007/s12035-019-01716-4
}}
==RPIA==
 
{{medline-entry
|title=Suppression of p16 Induces mTORC1-Mediated Nucleotide Metabolic Reprogramming.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31433975
 
|mesh-terms=* Aldose-Ketose Isomerases
* Animals
* Cell Line
* Cellular Senescence
* Cyclin-Dependent Kinase Inhibitor p16
* Gene Knockdown Techniques
* Humans
* Male
* Mechanistic Target of Rapamycin Complex 1
* Mice, SCID
* Nucleotides
* Pentose Phosphate Pathway
* Protein Biosynthesis
|keywords=* BRAF
* cancer metabolism
* cell cycle
* melanoma
* nevi
* pancreatic cancer
* pentose phosphate pathway
* ribonucleotide reductase M2
* ribose-5-phosphate isomerase A
* senescence
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6716532
}}
==RPS19BP1==
 
{{medline-entry
|title=Material basis, effect, and mechanism of ethanol extract of Pinellia ternata tubers on oxidative stress-induced cell senescence.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32659678
 
 
|keywords=* Oxidative stress
* Pinellia ternata
* SIRT1
* Senescence
|full-text-url=https://sci-hub.do/10.1016/j.phymed.2020.153275
}}
==RTEL1==
 
{{medline-entry
|title=Telomere length and aging-related outcomes in humans: A Mendelian randomization study in 261,000 older participants.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31444995
 
|mesh-terms=* Adult
* Aged
* Aged, 80 and over
* Aging
* Cohort Studies
* Female
* Humans
* Male
* Mendelian Randomization Analysis
* Middle Aged
* Risk Factors
* Telomere Homeostasis
|keywords=* TERT
* UK Biobank
* anti-aging
* cellular senescence
* centenarians
* frailty
* longevity
* sarcopenia
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6826144
}}
==RXFP3==
 
{{medline-entry
|title=The [[RXFP3]] receptor is functionally associated with cellular responses to oxidative stress and DNA damage.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31794429
 
|mesh-terms=* Camptothecin
* Computational Biology
* DNA Damage
* Felodipine
* GTPase-Activating Proteins
* Gene Expression Regulation
* Gene Regulatory Networks
* HEK293 Cells
* Humans
* Oxidative Stress
* RNA, Messenger
* Receptors, G-Protein-Coupled
* Topoisomerase I Inhibitors
|keywords=* DNA damage
* GPCR
* aging
* relaxin 3
* relaxin family peptide 3 receptor
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6932917
}}
==S100A4==
 
{{medline-entry
|title=Protective role of mesenchymal stem cells and mesenchymal stem cell-derived exosomes in cigarette smoke-induced mitochondrial dysfunction in mice.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31678243
 
|mesh-terms=* Alarmins
* Animals
* Cytokines
* Exosomes
* Lung
* Mesenchymal Stem Cells
* Mice
* Mitochondria
* Mitophagy
* Oxidative Phosphorylation
* Smoke
* Tobacco
|keywords=* COPD
* Cellular Senescence
* Exosomes
* Mesenchymal stem cells
* Mitochondria
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6894395
}}
==S100A9==
 
{{medline-entry
|title=Cigarette smoke induction of [[S100A9]] contributes to chronic obstructive pulmonary disease.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32964723
 
 
|keywords=* Cigarette smoke
* S100A9
* aging
* kinase
* pulmonary function
|full-text-url=https://sci-hub.do/10.1152/ajplung.00207.2020
}}
{{medline-entry
|title=Modulation of KDM1A with vafidemstat rescues memory deficit and behavioral alterations.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32469975
 
|mesh-terms=* Aging
* Alzheimer Disease
* Animals
* Behavior, Animal
* Brain
* Disease Models, Animal
* Enzyme Inhibitors
* Epigenesis, Genetic
* Female
* Gene Expression
* Hippocampus
* Histone Demethylases
* Humans
* Male
* Memory Disorders
* Mice
* Mice, Inbred C57BL
* Mice, Mutant Strains
* Monoamine Oxidase Inhibitors
* Oxadiazoles
* Rats
* Rats, Sprague-Dawley
 
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7259601
}}
{{medline-entry
|title=Cellular senescence induced by [[S100A9]] in mesenchymal stromal cells through NLRP3 inflammasome activation.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31727865
 
|mesh-terms=* Adolescent
* Adult
* Aged
* Aged, 80 and over
* Calgranulin B
* Case-Control Studies
* Cell Line
* Cells, Cultured
* Cellular Reprogramming
* Cellular Senescence
* Female
* Humans
* Inflammasomes
* Interleukin-1beta
* Male
* Mesenchymal Stem Cells
* Middle Aged
* Myelodysplastic Syndromes
* NLR Family, Pyrin Domain-Containing 3 Protein
* Reactive Oxygen Species
* Signal Transduction
* Stem Cell Niche
* Toll-Like Receptor 4
* Up-Regulation
* Young Adult
|keywords=* NLRP3
* S100A9
* cellular senescence
* mesenchymal stromal cells
* myelodysplastic syndromes
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6874461
}}
{{medline-entry
|title=[[S100A9]] extends lifespan in insulin deficiency.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31391467
 
|mesh-terms=* Animals
* Calgranulin B
* Diabetes Mellitus, Experimental
* Diphtheria Toxin
* Fatty Acids
* Humans
* Hyperglycemia
* Insulin
* Leptin
* Liver
* Longevity
* Male
* Mice
* Mice, Knockout
* Oxidation-Reduction
* Signal Transduction
* Streptozocin
* Toll-Like Receptor 4
 
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6686003
}}
==S100B==
 
{{medline-entry
|title=Aging protects rat cortical slices against to oxygen-glucose deprivation induced damage.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32064981
 
 
|keywords=* Aging
* LDH
* S100B
* edema
* oxygen-glucose deprivation
|full-text-url=https://sci-hub.do/10.1080/00207454.2020.1730830
}}
==S1PR1==
 
{{medline-entry
|title=Aging Suppresses Sphingosine-1-Phosphate Chaperone ApoM in Circulation Resulting in Maladaptive Organ Repair.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32544390
 
 
|keywords=* aging
* endothelial cell
* fibrosis
* kidney repair
* lipoprotein
* lung regeneration
* sphingosine-1-phosphate receptor
* vascular barrier
* vascular niche
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7607448
}}
==SAG==
 
{{medline-entry
|title=WRKY42 transcription factor positively regulates leaf senescence through modulating SA and ROS synthesis in Arabidopsis thaliana.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32634860
 
 
|keywords=*
WRKY42
 
* Arabidopsis
* leaf senescence
* reactive oxygen species
* salicylic acid
|full-text-url=https://sci-hub.do/10.1111/tpj.14914
}}
{{medline-entry
|title=Neurogenesis in the inner ear: the zebrafish statoacoustic ganglion provides new neurons from a Neurod/Nestin-positive progenitor pool well into adulthood.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32165493
 
|mesh-terms=* Adult Stem Cells
* Aging
* Animals
* Animals, Genetically Modified
* Basic Helix-Loop-Helix Transcription Factors
* Cell Differentiation
* Ear, Inner
* Embryo, Nonmammalian
* Ganglia, Sensory
* Gene Expression Regulation, Developmental
* Hair Cells, Auditory
* Larva
* Nerve Tissue Proteins
* Nestin
* Neural Stem Cells
* Neurogenesis
* Sensory Receptor Cells
* Stem Cell Niche
* Zebrafish
|keywords=* Inner ear
* Neuronal stem cells
* PNS
* Zebrafish
|full-text-url=https://sci-hub.do/10.1242/dev.176750
}}
==SAT1==
 
{{medline-entry
|title=Triethylenetetramine (trientine): a caloric restriction mimetic with a new mode of action.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32544364
 
 
|keywords=* Acetylation
* SAT1
* aging
* autophagy
* copper
* metabolomics
* obesity
* spermidine
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7469548
}}
==SATB1==
 
{{medline-entry
|title=Loss of [[SATB1]] Induces p21-Dependent Cellular Senescence in Post-mitotic Dopaminergic Neurons.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31543366
 
|mesh-terms=* Aging
* Animals
* Cells, Cultured
* Cellular Senescence
* Cyclin-Dependent Kinase Inhibitor p21
* Dopaminergic Neurons
* Epigenetic Repression
* Gene Knockdown Techniques
* Humans
* Matrix Attachment Region Binding Proteins
* Mice
* Mice, Knockout
* Mitosis
* Parkinson Disease
* Protein Binding
|keywords=* Parkinson’s disease
* SATB1
* cellular senescence
* dopamine
* neurodegeneration
* neuroinflammation
* p21
* senolytics
* stem cells
* transcriptomics
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7493192
}}
==SCD==
 
{{medline-entry
|title=Cognitive training and brain stimulation in prodromal Alzheimer's disease (AD-Stim)-study protocol for a double-blind randomized controlled phase IIb (monocenter) trial.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/33160420
 
 
|keywords=* Aging
* Decision-making
* Mild cognitive impairment
* Subjective cognitive decline
* Transcranial direct current stimulation
* Transfer
* Working memory
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7648990
}}
{{medline-entry
|title=Blood Pressure in Different Dementia Disorders, Mild Cognitive Impairment, and Subjective Cognitive Decline.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/33110409
 
 
|keywords=* Alzheimer’s disease
* aging
* blood pressure
* mild cognitive impairment
* subjective cognitive decline
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7488384
}}
{{medline-entry
|title=Known-Groups and Convergent Validity of the Telephone Rey Auditory Verbal Learning Test total Learning Scores for Distinguishing Between Older Adults With Amnestic Cognitive Impairment and Subjective Cognitive Decline.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/33067996
 
 
|keywords=* aging
* cognitive impairment
* neuropsychological assessment
|full-text-url=https://sci-hub.do/10.1093/arclin/acaa085
}}
{{medline-entry
|title=Subjective cognitive decline as a predictor of future cognitive decline: a systematic review.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32973979
 
 
|keywords=* Alzheimer disease.
* aging
* cognition
* cognitive dysfunction
* dementia
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7500809
}}
{{medline-entry
|title=Geriatric assessment for older adults with sickle cell disease: protocol for a prospective cohort pilot study.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32974042
 
 
|keywords=* Aging
* Functional assessment
* Geriatric assessment
* Geriatrics
* Older adults
* Sickle cell
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7495855
}}
{{medline-entry
|title=Prevalence and psychosocial correlates of subjectively perceived decline in five cognitive domains: Results from a population-based cohort study in Germany.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32510658
 
 
|keywords=* Germany
* cognitive aging
* cognitive complaints
* cohort study
* prevalence
* subjective cognitive decline
|full-text-url=https://sci-hub.do/10.1002/gps.5359
}}
{{medline-entry
|title=SC411 treatment can enhance survival in a mouse model of sickle cell disease.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32447175
 
 
|keywords=* Aging
* Cerebral blood flow
* Docosahexaenoic acid
* Neuroinflammation
* Sickle cell disease
* Working memory
|full-text-url=https://sci-hub.do/10.1016/j.plefa.2020.102110
}}
{{medline-entry
|title=DNA fragmentation of human spermatozoa: Simple assessment of single- and double-strand DNA breaks and their respective dynamic behavioral response.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32416007
 
 
|keywords=* DNA longevity
* sperm DNA damage
* sperm DNA dynamics
* sperm DNA fragmentation
* sperm chromatin dispersion test
|full-text-url=https://sci-hub.do/10.1111/andr.12819
}}
{{medline-entry
|title=Psychometric Cognitive Decline Precedes the Advent of Subjective Cognitive Decline in the Evolution of Alzheimer's Disease.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32388509
 
 
|keywords=* Alzheimer’s disease
* Brain aging
* Cognitive decline
* Cognitive testing
* Longitudinal studies
* Psychometric cognition
|full-text-url=https://sci-hub.do/10.1159/000507286
}}
{{medline-entry
|title=Serum alkaline phosphatase is elevated and inversely correlated with cognitive functions in subjective cognitive decline: results from the ReGAl 2.0 project.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32363431
 
 
|keywords=* Aging
* Biochemistry
* Cognition
* Dementia
* Geriatric medicine
|full-text-url=https://sci-hub.do/10.1007/s40520-020-01572-6
}}
{{medline-entry
|title=Changes in Activity Participation Among Older Adults With Subjective Cognitive Decline or Objective Cognitive Deficits.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32010049
 
 
|keywords=* activity participation
* aging
* daily functioning
* metamemory
* subjective cognitive decline
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6974583
}}
{{medline-entry
|title=Age, gender and drug therapy influences on Tpeak-tend interval and on electrical risk score.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32023499
 
 
|keywords=* Aging
* Electrical risk score
* Gender
* Mortality
* QTc
* Repolarization phase
* T peak-tend interval
|full-text-url=https://sci-hub.do/10.1016/j.jelectrocard.2020.01.009
}}
{{medline-entry
|title=Comorbid Chronic Conditions Among Older Adults with Subjective Cognitive Decline, United States, 2015-2017.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31915725
 
 
|keywords=* Aging
* Chronic disease
* Cognitive dysfunction
* Dementia
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6938465
}}
{{medline-entry
|title=Resting State BOLD Variability Is Linked to White Matter Vascular Burden in Healthy Aging but Not in Older Adults With Subjective Cognitive Decline.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31920589
 
 
|keywords=* Alzheimer’s disease
* aging
* biomarkers
* cerebrovascular health
* signal variability
* subjective cognitive decline
* white matter
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6936515
}}
{{medline-entry
|title=Estimated Life Expectancy and Income of Patients With Sickle Cell Disease Compared With Those Without Sickle Cell Disease.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31730182
 
|mesh-terms=* Adolescent
* Adult
* Aged
* Anemia, Sickle Cell
* Child
* Child, Preschool
* Cohort Studies
* Female
* Forecasting
* Humans
* Income
* Infant
* Life Expectancy
* Male
* Middle Aged
* Models, Statistical
* Quality-Adjusted Life Years
* United States
* Young Adult
 
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6902797
}}
{{medline-entry
|title=Does Empirically Derived Classification of Individuals with Subjective Cognitive Complaints Predict Dementia?
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31703450
 
 
|keywords=* Compostela aging study
* cluster analysis
* cognitive aging
* dementia
* mild cognitive impairment
* screening and diagnosis
* subjective cognitive complaints
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6895967
}}
{{medline-entry
|title=Spatiotemporal Oscillatory Patterns During Working Memory Maintenance in Mild Cognitive Impairment and Subjective Cognitive Decline.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31522594
 
|mesh-terms=* Aged
* Aging
* Brain Waves
* Cerebral Cortex
* Cognitive Dysfunction
* Cortical Synchronization
* Female
* Humans
* Magnetoencephalography
* Male
* Memory, Short-Term
* Task Performance and Analysis
|keywords=* Alzheimer’s disease (AD)
* Induced oscillatory activity
* magnetoencephalography (MEG)
* mild cognitive impairment (MCI)
* subjective cognitive decline (SCD)
* working memory (WM)
|full-text-url=https://sci-hub.do/10.1142/S0129065719500199
}}
{{medline-entry
|title=Microstructural Correlates and Laterality Effect of Prospective Memory in Non-Demented Adults with Memory Complaints.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31466053
 
|mesh-terms=* Aged
* Aged, 80 and over
* Corpus Callosum
* Diffusion Tensor Imaging
* Female
* Frontal Lobe
* Functional Laterality
* Humans
* Magnetic Resonance Imaging
* Male
* Memory Disorders
* Middle Aged
* Nerve Fibers
* Neuropsychological Tests
* Retrospective Studies
* Surveys and Questionnaires
* Taiwan
|keywords=* Aging
* Alzheimer’s disease
* Cognitive complaints
* Diffusion tensor imaging
* Lateralization
* Prospective memory
* Tract-based spatial statistics
|full-text-url=https://sci-hub.do/10.1159/000501366
}}
==SCN2A==
 
{{medline-entry
|title=Na 1.2 haploinsufficiency in Scn2a knock-out mice causes an autistic-like phenotype attenuated with age.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31501495
 
|mesh-terms=* Aging
* Animals
* Autism Spectrum Disorder
* Gene Knockout Techniques
* Haploinsufficiency
* Memory
* Mice
* NAV1.2 Voltage-Gated Sodium Channel
* Phenotype
* Spatial Learning
 
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6733925
}}
==SCN2B==
 
{{medline-entry
|title=MicroRNA‑449a regulates the progression of brain aging by targeting [[SCN2B]] in SAMP8 mice.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32124967
 
|mesh-terms=* Aging
* Animals
* Brain
* Gene Expression Regulation
* Male
* Mice
* Mice, Transgenic
* MicroRNAs
* Voltage-Gated Sodium Channel beta-2 Subunit
 
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7053848
}}
==SCO1==
 
{{medline-entry
|title=Real-Time PCR Analysis of Metabolism-Related Genes in a Long-Lived Model of C. elegans.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32219749
 
 
|keywords=* Caenorhabditis elegans
* Energy metabolism
* Longevity
* TaqMan real-time PCR
* p53/CEP-1
|full-text-url=https://sci-hub.do/10.1007/978-1-0716-0471-7_12
}}
==SDC1==
 
{{medline-entry
|title=Olmesartan alleviates bleomycin-mediated vascular smooth muscle cell senescence via the miR-665/[[SDC1]] axis.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/33042414
 
 
|keywords=* Atherosclerosis
* MiR-665
* SDC1
* olmesartan
* vascular smooth muscle cell senescence
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7540088
}}
{{medline-entry
|title=Sulfated syndecan 1 is critical to preventing cellular senescence by modulating fibroblast growth factor receptor endocytosis.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32530114
 
 
|keywords=* FGFR1
* SDC1
* cellular senescence
* endocytosis
* heparan sulfation
|full-text-url=https://sci-hub.do/10.1096/fj.201902714R
}}
==SDHB==
 
{{medline-entry
|title=Mitochondrial Signatures in Circulating Extracellular Vesicles of Older Adults with Parkinson's Disease: Results from the EXosomes in PArkiNson's Disease (EXPAND) Study.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32059608
 
 
|keywords=* aging
* biomarkers
* exosomes
* mitochondrial dynamics
* mitochondrial quality control
* mitochondrial-derived vesicles
* mitochondrial-lysosomal axis
* mitophagy
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7074517
}}
==SDS==
 
{{medline-entry
|title=Semiautomatic morphometric analysis of skeletal muscle obtained by needle biopsy in older adults.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32946050
 
 
|keywords=* Aging skeletal muscle
* Morphometric analysis
* Myosin heavy chain
* Semiautomatic muscle analysis
* Skeletal muscle
|full-text-url=https://sci-hub.do/10.1007/s11357-020-00266-1
}}
{{medline-entry
|title=Effects of late-onset dietary intake of salidroside on insulin/insulin-like growth factor-1 (IGF-1) signaling pathway of the annual fish Nothobranchius guentheri.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32858432
 
 
|keywords=* Aging
* Annual fish
* Lifespan
* Nothobranchius
* Salidroside
|full-text-url=https://sci-hub.do/10.1016/j.archger.2020.104233
}}
{{medline-entry
|title=Quantification of Insoluble Protein Aggregation in Caenorhabditis elegans during Aging with a Novel Data-Independent Acquisition Workflow.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32831297
 
|mesh-terms=* Aging
* Animals
* Caenorhabditis elegans
* Caenorhabditis elegans Proteins
* Longevity
* Protein Aggregates
* Proteome
* Proteomics
* Workflow
 
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7519758
}}
{{medline-entry
|title=Skeletal Muscle Myofibrillar Protein Abundance Is Higher in Resistance-Trained Men, and Aging in the Absence of Training May Have an Opposite Effect.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31936810
 
 
|keywords=* aging
* myofibrillar protein
* proteomics
* resistance training
* sarcoplasmic protein
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7022975
}}
{{medline-entry
|title=Characterization, evaluation of nutritional parameters of Radix isatidis protein and its antioxidant activity in D-galactose induced ageing mice.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31694618
 
|mesh-terms=* Aging
* Animals
* Antioxidants
* Catalase
* Drugs, Chinese Herbal
* Galactose
* Humans
* Kidney
* Liver
* Male
* Malondialdehyde
* Mice
* Mice, Inbred ICR
* Molecular Weight
* Oxidative Stress
* Plant Proteins
* Plant Roots
* Superoxide Dismutase
|keywords=* Antioxidant activity
* D-galactose
* Oxidative damage
* Protein composition
* Radix isatidis protein
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6836523
}}
{{medline-entry
|title=[Effects of silver nanoparticles on pupation, eclosion, life span, apoptosis and protein expression in Drosophila melanogaster].
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31621246
 
|mesh-terms=* Animals
* Apoptosis
* Drosophila melanogaster
* Longevity
* Metal Nanoparticles
* Oregon
* Silver
|keywords=* Drosophila melanogaster
* apoptosis
* protein expression
* silver nanoparticles
|full-text-url=https://sci-hub.do/10.13287/j.1001-9332.201910.036
}}
{{medline-entry
|title=Does an Age-Specific Treatment Program Augment the Efficacy of a Cognitive-Behavioral Weight Loss Program in Adolescence and Young Adulthood? Results from a Controlled Study.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31480678
 
|mesh-terms=* Adolescent
* Aging
* Behavior Therapy
* Cognitive Behavioral Therapy
* Female
* Humans
* Male
* Weight Loss
* Weight Reduction Programs
* Young Adult
|keywords=* adolescents
* behavioral weight loss
* controlled trial
* emerging adults
* obesity
* quality of life
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6769959
}}
==SELENBP1==
 
{{medline-entry
|title=A Caenorhabditis elegans ortholog of human selenium-binding protein 1 is a pro-aging factor protecting against selenite toxicity.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31557719
 
|mesh-terms=* Animals
* Caenorhabditis elegans
* Caenorhabditis elegans Proteins
* Cytoplasm
* Drug Resistance
* Gene Expression Regulation
* Humans
* Longevity
* Membrane Proteins
* Oxidative Stress
* Paraquat
* Selenious Acid
* Selenium-Binding Proteins
* Structural Homology, Protein
|keywords=* Caenorhabditis elegans
* Lifespan
* Selenium-binding protein
* Stress signaling
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6812014
}}
==SELENOK==
 
{{medline-entry
|title=Dietary selenium deficiency and supplementation differentially modulate the expression of two ER-resident selenoproteins (selenoprotein K and selenoprotein M) in the ovaries of aged mice: Preliminary data.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32736983
 
 
|keywords=* Female fertility
* Ovarian aging
* Selenium
* Selenoprotein K
* Selenoprotein M
|full-text-url=https://sci-hub.do/10.1016/j.repbio.2020.07.006
}}
==SENP6==
 
{{medline-entry
|title=Molecular signature for senile and complicated cataracts derived from analysis of sumoylation enzymes and their substrates in human cataract lenses.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32827359
 
 
|keywords=* Pax6
* SUMO1
* SUMO2/3
* aging
* apoptosis
* cataract
* de-sumoylation enzymes (SENPs)
* sumoylation ligases
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7576240
}}
==SERPINE1==
 
{{medline-entry
|title=Elevated circulating HtrA4 in preeclampsia may alter endothelial expression of senescence genes.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32056555
 
 
|keywords=* Endothelial aging
* Endothelial cells
* HtrA4
* Preeclampsia
* Senescence
|full-text-url=https://sci-hub.do/10.1016/j.placenta.2019.12.012
}}
==SESN2==
 
{{medline-entry
|title=Copy Number Alterations in Papillary Thyroid Carcinomas: Does Loss of [i][[SESN2]][/i] Have a Role in Age-related Different Prognoses?
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32859642
 
 
|keywords=* Papillary thyroid cancer
* SESN2
* aCGH
* deletion
* senescence
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7472442
}}
==SFN==
 
{{medline-entry
|title=The phytoprotective agent sulforaphane prevents inflammatory degenerative diseases and age-related pathologies via Nrf2-mediated hormesis.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/33160067
 
 
|keywords=* Aging
* Hormesis
* Inflammation
* Neuroprotection
* Nrf2
* Sulforaphane
|full-text-url=https://sci-hub.do/10.1016/j.phrs.2020.105283
}}
{{medline-entry
|title=Multi-Omic Analysis Reveals Different Effects of Sulforaphane on the Microbiome and Metabolome in Old Compared to Young Mice.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/33003447
 
 
|keywords=* aging
* biomarkers
* gut microbiome
* metabolome
* sulforaphane
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7599699
}}
{{medline-entry
|title=Sulforaphane controls the release of paracrine factors by keratinocytes and thus mitigates particulate matter-induced premature skin aging by suppressing melanogenesis and maintaining collagen homeostasis.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32659677
 
 
|keywords=* Coculture system
* Collagen homeostasis
* Melanogenesis
* Particulate matter 2.5
* Premature skin aging
* Sulforaphane
|full-text-url=https://sci-hub.do/10.1016/j.phymed.2020.153276
}}
{{medline-entry
|title=Sulforaphane Inhibits Autophagy and Induces Exosome-Mediated Paracrine Senescence via Regulating mTOR/TFE3.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32476238
 
 
|keywords=* ROS
* autophagy
* exosome
* senescence
* sulforaphane
|full-text-url=https://sci-hub.do/10.1002/mnfr.201901231
}}
==SFPQ==
 
{{medline-entry
|title=Downregulation of LncRNA NORAD promotes Ox-LDL-induced vascular endothelial cell injury and atherosclerosis.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32267831
 
 
|keywords=* IL-8
* NORAD
* cell apoptosis
* cell senescence
* ox-LDL
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7185106
}}
==SGK1==
 
{{medline-entry
|title=Epigenetic Regulation of KL (Klotho) via H3K27me3 (Histone 3 Lysine [K] 27 Trimethylation) in Renal Tubule Cells.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32223380
 
 
|keywords=* AKT
* EZH2
* aging
* mTOR
* p53
|full-text-url=https://sci-hub.do/10.1161/HYPERTENSIONAHA.120.14642
}}
==SHBG==
 
{{medline-entry
|title=Endogenous Testosterone Levels and the Risk of Incident Cardiovascular Events in Elderly Men: The MrOS Prospective Study.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32337470
 
 
|keywords=* aging
* cardiovascular events
* men
* testosterone
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7173399
}}
{{medline-entry
|title=Associations of Endogenous Sex Hormones with Carotid Plaque Burden and Characteristics in Midlife Women.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31900485
 
 
|keywords=* aging
* atherosclerosis
* carotid artery
* hormones
* women
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7077951
}}
{{medline-entry
|title=Analysis of the Relationship between the Levels of Androgens and Biochemical Bone Markers in Men Aged 60-75 Years.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31877849
 
|mesh-terms=* Absorptiometry, Photon
* Aged
* Aging
* Androgens
* Biomarkers
* Bone Density
* Bone Remodeling
* Bone and Bones
* Collagen Type I
* Dehydroepiandrosterone Sulfate
* Estradiol
* Humans
* Male
* Middle Aged
* Parathyroid Hormone
* Peptide Fragments
* Peptides
* Procollagen
* Sex Hormone-Binding Globulin
* Testosterone
|keywords=* aging men
* biochemical bone markers
* levels of androgens
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6982106
}}
{{medline-entry
|title=Testosterone and Estrone Increase From the Age of 70 Years: Findings From the Sex Hormones in Older Women Study.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31408149
 
|mesh-terms=* Aged
* Aged, 80 and over
* Aging
* Biomarkers
* Community-Based Participatory Research
* Cross-Sectional Studies
* Dehydroepiandrosterone
* Estrone
* Female
* Follow-Up Studies
* Humans
* Obesity
* Overweight
* Prognosis
* Testosterone
 
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6830527
}}
==SHD==
 
{{medline-entry
|title=Does self-reported hearing difficulty decrease older adults' cognitive and physical functioning? The mediating role of social isolation.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/33036703
 
|mesh-terms=* Activities of Daily Living
* Aged
* Aged, 80 and over
* Cognition
* Cognitive Dysfunction
* Cohort Studies
* Disabled Persons
* Female
* Health Status
* Hearing Loss
* Humans
* Longevity
* Longitudinal Studies
* Male
* Mental Status and Dementia Tests
* Odds Ratio
* Self Report
* Social Isolation
|keywords=* Cognitive impairment
* Older people
* Physical disability
* Self-reported hearing difficulty
* Social isolation
|full-text-url=https://sci-hub.do/10.1016/j.maturitas.2020.06.011
}}
==SHH==
 
{{medline-entry
|title=Recent advances in [[SHH]] medulloblastoma progression: tumor suppressor mechanisms and the tumor microenvironment.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31700613
 
|mesh-terms=* Animals
* Cerebellar Neoplasms
* Cerebellum
* Hedgehog Proteins
* Humans
* Medulloblastoma
* Mice
* Tumor Microenvironment
|keywords=* Medulloblastoma
* Sonic hedgehog
* cell senescence
* tumor microenvironment
* tumor progression
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6820827
}}
==SI==
 
{{medline-entry
|title=Microarray Profiling Reveals Distinct Circulating miRNAs in Aged Male and Female Mice Subjected to Post-stroke Social Isolation.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/33074466
 
 
|keywords=* Aging
* Biomarkers
* Sex differences
* Social isolation
* Stroke
* miRNAs
|full-text-url=https://sci-hub.do/10.1007/s12017-020-08622-2
}}
{{medline-entry
|title=Is Heart Rate a Confounding Factor for Photoplethysmography Markers? A Systematic Review.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32290168
 
|mesh-terms=* Aging
* Cardiovascular Diseases
* Diabetes Mellitus, Type 2
* Female
* Fingers
* Heart Rate
* Humans
* Male
* Microcirculation
* Photoplethysmography
* Vascular Stiffness
|keywords=* cardiovascular disease
* heart rate
* photoplethysmography
* reflection index
* second derivative of photoplethysmography
* stiffness index
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7177218
}}
{{medline-entry
|title=Survival time after marked reduction in oral intake in terminally ill noncancer patients: A retrospective study.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32161695
 
 
|keywords=* elderly
* geriatrics
* palliative medicine
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7060293
}}
{{medline-entry
|title=Adherence to Mediterranean diet moderates the association between multimorbidity and depressive symptoms in older adults.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32109694
 
|mesh-terms=* Aged
* Aged, 80 and over
* Cohort Studies
* Depression
* Diet, Mediterranean
* Healthy Aging
* Humans
* Multimorbidity
* Surveys and Questionnaires
|keywords=* Aging
* Depressive symptoms
* Mediterranean diet
* Mental health
* Multimorbidity
|full-text-url=https://sci-hub.do/10.1016/j.archger.2020.104022
}}
{{medline-entry
|title=Loneliness, Social Isolation, and Objectively Measured Physical Activity in Rural-Living Older Adults.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31860831
 
 
|keywords=* accelerometry
* aging
* health
* social well-being
* volunteering
|full-text-url=https://sci-hub.do/10.1123/japa.2019-0027
}}
{{medline-entry
|title=The associations between social support and negative social interaction with suicidal ideation in US Chinese older adults.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31650846
 
 
|keywords=* Chinese American
* Social support
* aging
* negative social interaction
* suicidal ideation
|full-text-url=https://sci-hub.do/10.1080/13607863.2019.1680953
}}
{{medline-entry
|title=Cell Senescence and Cerebral Small Vessel Disease in the Brains of People Aged 80 Years and Older.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31553444
 
|mesh-terms=* Aged, 80 and over
* Aging
* Brain
* Cellular Senescence
* Cerebral Arteries
* Cerebral Small Vessel Diseases
* Female
* Humans
* Male
* White Matter
|keywords=* Brain aging
* Cerebrovascular disease
* Senescence
* Small vessel disease
|full-text-url=https://sci-hub.do/10.1093/jnen/nlz088
}}
==SIK3==
 
{{medline-entry
|title=Quantitative and Qualitative Role of Antagonistic Heterogeneity in Genetics of Blood Lipids.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31566214
 
 
|keywords=* Age-related phenotypes
* Aging
* Genome-wide association studies
* Health span
* Life span
* Pleiotropy
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7518561
}}
==SIRT1==
 
{{medline-entry
|title=Anthocyanins attenuate endothelial dysfunction through regulation of uncoupling of nitric oxide synthase in aged rats.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/33274583
 
 
|keywords=* NO
* SIRT1
* anthocyanins
* eNOS deacetylation
* senescence
|full-text-url=https://sci-hub.do/10.1111/acel.13279
}}
{{medline-entry
|title=Sirtuins and Their Implications in Neurodegenerative Diseases from a Drug Discovery Perspective.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/33280374
 
 
|keywords=* Aging
* neurodegenerative diseases
* neuroprotective
* sirtuin
* sirtuin activators
* sirtuin inhibitors
|full-text-url=https://sci-hub.do/10.1021/acschemneuro.0c00696
}}
{{medline-entry
|title=Effects of alpha-mangostin on memory senescence induced by high glucose in human umbilical vein endothelial cells.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/33149857
 
 
|keywords=* Cellular senescence
* Diabetes
* Diabetes complications
* Endothelial cells
* Garcinia mangostana
* Hyperglycemia
* Mangostin
* Metabolic syndrome
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7585532
}}
{{medline-entry
|title=[[SIRT1]] Activation Using CRISPR/dCas9 Promotes Regeneration of Human Corneal Endothelial Cells through Inhibiting Senescence.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/33158256
 
 
|keywords=* CRISPR/dCas9
* SIRT1
* corneal endothelial cells
* senescence
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7694272
}}
{{medline-entry
|title=Histone Deacetylase [[SIRT1]], Smooth Muscle Cell Function, and Vascular Diseases.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/33117155
 
 
|keywords=* SIRT1
* SIRT1 activators
* calorie restriction
* senescence
* vascular diseases
* vascular smooth muscle cells
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7573826
}}
{{medline-entry
|title=6,4'-dihydroxy-7-methoxyflavanone protects against H O -induced cellular senescence by inducing [[SIRT1]] and inhibiting phosphatidylinositol 3-kinase/Akt pathway activation.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/33111210
 
 
|keywords=* 6,4′-dihydroxy-7-methoxyflavanone
* Akt
* Oxidative stress
* Premature senescence
* SIRT1
|full-text-url=https://sci-hub.do/10.1007/s11010-020-03951-z
}}
{{medline-entry
|title=Isoparvifuran isolated from Dalbergia odorifera attenuates H O -induced senescence of BJ cells through [[SIRT1]] activation and AKT/mTOR pathway inhibition.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/33010892
 
 
|keywords=* AKT/mTOR signaling pathway
* Antioxidant: SIRT1
* Cellular senescence
* Isoparvifuran
|full-text-url=https://sci-hub.do/10.1016/j.bbrc.2020.09.096
}}
{{medline-entry
|title=[[SIRT1]] Is the Target Gene for 2,3,5,4'-Tetrahydroxystilbene-2-O-β-D-Glucoside Alleviating the HUVEC Senescence.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/33013385
 
 
|keywords=* 2,3,5,4’-tetrahydroxystilbene-2-O-β-d-glucoside
* SIRT1
* human umbilical vein cells
* hydrogen peroxide
* senescence
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7508177
}}
{{medline-entry
|title=The Role of Sirtuins in Kidney Diseases.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32932720
 
 
|keywords=* acute kidney injury
* aging kidney
* chronic kidney disease
* diabetic nephropathy
* kidney
* sirtuins
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7555196
}}
{{medline-entry
|title=The effect of 12-week resistance exercise training on serum levels of cellular aging process parameters in elderly men.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32919015
 
 
|keywords=* Cellular senescence
* Elderly
* Resistance training
|full-text-url=https://sci-hub.do/10.1016/j.exger.2020.111090
}}
{{medline-entry
|title=Virus-Induced Asthma Exacerbations: [[SIRT1]] Targeted Approach.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32823491
 
 
|keywords=* SIRT1
* asthma
* cellular senescence
* exacerbations
* virus infection
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7464235
}}
{{medline-entry
|title=Novel resveratrol derivatives have diverse effects on the survival, proliferation and senescence of primary human fibroblasts.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32793997
 
 
|keywords=* Resveratrol
* SIRT1
* Senescence
* Toxicity
|full-text-url=https://sci-hub.do/10.1007/s10522-020-09896-6
}}
{{medline-entry
|title=Glucose restriction delays senescence and promotes proliferation of HUVECs via the AMPK/[[SIRT1]]-FOXA3-Beclin1 pathway.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32768436
 
 
|keywords=* Beclin1
* Endothelial cells
* FOXA3
* Glucose restriction
* Proliferation
* Senescence
|full-text-url=https://sci-hub.do/10.1016/j.exger.2020.111053
}}
{{medline-entry
|title=Therapeutic Effects of SRT2104 on Lung Injury in Rats with Emphysema via Reduction of Type II Alveolar Epithelial Cell Senescence.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32722945
 
 
|keywords=* Sirtuin 1
* alveolar epithelial cells
* cellular senescence
* chronic obstructive pulmonary disease
* cigarette smoking
|full-text-url=https://sci-hub.do/10.1080/15412555.2020.1797657
}}
{{medline-entry
|title=Latifolin Inhibits Oxidative Stress-Induced Senescence via Upregulation of [[SIRT1]] in Human Dermal Fibroblasts.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32404543
 
 
|keywords=* human dermal fibroblast
* latifolin
* mammalian target of rapamycin
* oxidative stress
* senescence
* silent information regulator 1
|full-text-url=https://sci-hub.do/10.1248/bpb.b20-00094
}}
{{medline-entry
|title=SRT1720-induced activation of [[SIRT1]] alleviates vascular smooth muscle cell senescence through PKA-dependent phosphorylation of AMPKα at Ser485.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32421926
 
 
|keywords=* SIRT1
* SRT1720
* VSMC senescence
* p-AMPK (Ser485)
* telomere length
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7327920
}}
{{medline-entry
|title=miR-128 plays a critical role in murine osteoclastogenesis and estrogen deficiency-induced bone loss.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32292498
 
 
|keywords=* PMOP
* aging
* inflammation
* miR-128
* osteoclastogenesis
* ovariectomy
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7150474
}}
{{medline-entry
|title=Lymphocyte senescence in COPD is associated with decreased sirtuin 1 expression in steroid resistant pro-inflammatory lymphocytes.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32270742
 
 
|keywords=* CD28nullCD8+ T and NKT-like cells
* COPD
* IFNγ and TNFα
* SIRT1
* lymphocyte senescence
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7153179
}}
{{medline-entry
|title=Therapeutic effects of hydro-alcoholic leaf extract of Withania somnifera on age-induced changes in daily rhythms of Sirt1, Nrf2 and Rev-erbα in the SCN of male Wistar rats.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32249404
 
 
|keywords=* Aging
* Ashwagandha
* Circadian clock
* NRF2
* SCN
* SIRT1
|full-text-url=https://sci-hub.do/10.1007/s10522-020-09875-x
}}
{{medline-entry
|title=The Serum Concentration of Anti-Aging Proteins, Sirtuin1 and αKlotho in Patients with End-Stage Kidney Disease on Maintenance Hemodialysis.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32214805
 
|mesh-terms=* Age Factors
* Aged
* Aging
* Biomarkers
* Blood Pressure
* Cardiovascular Diseases
* Case-Control Studies
* Diabetes Complications
* Echocardiography
* Female
* Glucuronidase
* Heart Ventricles
* Humans
* Kidney
* Kidney Failure, Chronic
* Male
* Middle Aged
* Renal Dialysis
* Sirtuin 1
* Stroke Volume
|keywords=* chronic kidney disease
* hemodialysis
* sirtuin1
* αKlotho
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7084123
}}
{{medline-entry
|title=Small extracellular vesicles deliver miR-21 and miR-217 as pro-senescence effectors to endothelial cells.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32158519
 
 
|keywords=* Cellular senescence
* DNMT1
* SIRT1
* extracellular vesicles
* microRNAs
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7048230
}}
{{medline-entry
|title=Spatiotemporal gating of [[SIRT1]] functions by O-GlcNAcylation is essential for liver metabolic switching and prevents hyperglycemia.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32152092
 
|mesh-terms=* Acetylglucosamine
* Aging
* Animals
* Fasting
* Gluconeogenesis
* Glycosylation
* HEK293 Cells
* Homeostasis
* Humans
* Hyperglycemia
* Insulin Resistance
* Liver
* Male
* Mice
* Mice, Inbred C57BL
* Obesity
* Phosphorylation
* Protein Processing, Post-Translational
* Sirtuin 1
* Spatio-Temporal Analysis
|keywords=* PGC1α
* fed–fast cycle
* gluconeogenesis
* insulin signaling
* ubiquitinylation
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7104039
}}
{{medline-entry
|title=Hydrogen Sulfide Inhibits Homocysteine-Induced Neuronal Senescence by Up-Regulation of [[SIRT1]].
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32132865
 
 
|keywords=* SIRT1
* cell senescence
* homocysteine
* hydrogen sulfide
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7053352
}}
{{medline-entry
|title=[[SIRT1]] and aging related signaling pathways.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32084459
 
 
|keywords=* Aging
* Deacetylate
* NAD(+)
* SIRT1
* Signaling pathways
|full-text-url=https://sci-hub.do/10.1016/j.mad.2020.111215
}}
{{medline-entry
|title=Tropisetron protects against brain aging via attenuating oxidative stress, apoptosis and inflammation: The role of [[SIRT1]] signaling.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32088214
 
|mesh-terms=* Aging
* Animals
* Antioxidants
* Apoptosis
* Brain
* Drug Administration Schedule
* Galactose
* Gene Expression Regulation
* Inflammation
* Injections, Intraperitoneal
* Injections, Subcutaneous
* Interleukin-6
* Male
* Mice
* Mitochondria
* Neurons
* Nitric Oxide
* Oxidative Stress
* Proto-Oncogene Proteins c-bcl-2
* Reactive Oxygen Species
* Serotonin 5-HT3 Receptor Antagonists
* Sirtuin 1
* Tropisetron
* Tumor Necrosis Factor-alpha
* bcl-2-Associated X Protein
|keywords=* Aging
* Brain
* Neurotoxicity
* Sirtuin 1
* Tropisetron
* d-galactose
|full-text-url=https://sci-hub.do/10.1016/j.lfs.2020.117452
}}
{{medline-entry
|title=Nicotinamide mononucleotide (NMN) supplementation promotes neurovascular rejuvenation in aged mice: transcriptional footprint of [[SIRT1]] activation, mitochondrial protection, anti-inflammatory, and anti-apoptotic effects.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32056076
 
 
|keywords=* Aging
* Geroscience
* Mitochondria dysfunction
* Transcriptomics
* Vascular cognitive impairment
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7206476
}}
{{medline-entry
|title=Deacetylation of MRTF-A by [[SIRT1]] defies senescence induced down-regulation of collagen type I in fibroblast cells.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32061777
 
|mesh-terms=* Acetylation
* Animals
* Benzamides
* Carbazoles
* Cellular Senescence
* Collagen Type I
* Down-Regulation
* Embryo, Mammalian
* Fibroblasts
* HEK293 Cells
* Heterocyclic Compounds, 4 or More Rings
* Humans
* Mice
* Mutation
* Naphthols
* Primary Cell Culture
* Promoter Regions, Genetic
* RNA, Small Interfering
* Resveratrol
* Sirtuin 1
* Trans-Activators
|keywords=* Collagen type I
* Fibroblast
* Lysine deacetylation
* Post-translational modification
* Senescence
* Transcriptional regulation
|full-text-url=https://sci-hub.do/10.1016/j.bbadis.2020.165723
}}
{{medline-entry
|title=Chronic Polyphenon-60 or Catechin Treatments Increase Brain Monoamines Syntheses and Hippocampal [[SIRT1]] Levels Improving Cognition in Aged Rats.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31991916
 
|mesh-terms=* Age Factors
* Animals
* Behavior, Animal
* Biogenic Monoamines
* Catechin
* Cognition
* Cognitive Aging
* Corpus Striatum
* Hippocampus
* Male
* Memory, Episodic
* Memory, Short-Term
* Neuroprotective Agents
* Rats, Sprague-Dawley
* Sirtuin 1
* Time Factors
|keywords=* NF-κB
* RBAP46/48
* SIRT1
* brain aging
* brain monoamine synthesis
* catechin
* green tea
* memory
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7071257
}}
{{medline-entry
|title=Duck Oil-loaded Nanoemulsion Inhibits Senescence of Angiotensin II-treated Vascular Smooth Muscle Cells by Upregulating [[SIRT1]].
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31970335
 
 
|keywords=* SIRT1
* angiotensin II
* duck oil
* nanoemulsion
* senescence
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6957441
}}
{{medline-entry
|title=Two novel [[SIRT1]] activators, SCIC2 and SCIC2.1, enhance [[SIRT1]]-mediated effects in stress response and senescence.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31942817
 
 
|keywords=* Sirtuins
* drug discovery
* epigenetic modulators
* senescence
* stress response
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7574383
}}
{{medline-entry
|title=Hydrogen sulfide attenuates mitochondrial dysfunction-induced cellular senescence and apoptosis in alveolar epithelial cells by upregulating sirtuin 1.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31881011
 
|mesh-terms=* A549 Cells
* Alveolar Epithelial Cells
* Apoptosis
* Cellular Senescence
* Humans
* Hydrogen Sulfide
* Mitochondria
* Oxidative Stress
* Sirtuin 1
* Smoke
* Tobacco
* Up-Regulation
|keywords=* alveolar epithelial cell
* cigarette smoke extract
* hydrogen sulfide
* mitochondria injury
* senescence
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6949053
}}
{{medline-entry
|title=The protective role of omentin-1 in IL-1β-induced chondrocyte senescence.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31852248
 
|mesh-terms=* Adipokines
* Caveolin 1
* Cell Line, Tumor
* Cellular Senescence
* Chondrocytes
* Cyclin-Dependent Kinase Inhibitor p21
* Cytoprotection
* G1 Phase Cell Cycle Checkpoints
* Humans
* Interleukin-1beta
* Plasminogen Activator Inhibitor 1
* Sirtuin 1
* Transcriptional Activation
|keywords=* IL-1β
* Omentin-1
* SIRT-1
* chondrocyte senescence
|full-text-url=https://sci-hub.do/10.1080/21691401.2019.1699803
}}
{{medline-entry
|title=The Lifespan Extension Ability of Nicotinic Acid Depends on Whether the Intracellular NAD  Level Is Lower than the Sirtuin-Saturating Concentrations.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31878234
 
|mesh-terms=* Animals
* Caenorhabditis elegans
* Caenorhabditis elegans Proteins
* Caloric Restriction
* Cell Line
* Humans
* NAD
* Niacin
* Sirtuins
* beta-Galactosidase
|keywords=* C. elegans
* Hs68 cells
* NAD+
* calorie restriction mimetic
* lifespan
* nicotinic acid
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6982340
}}
{{medline-entry
|title=Alpha-mangostin decreased cellular senescence in human umbilical vein endothelial cells.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31792920
 
 
|keywords=* Alpha-mangostin
* Diabetes
* HUVEC
* High glucose
* SIRT1
* Senescence
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7214571
}}
{{medline-entry
|title=Central nervous system [[SIRT1]] expression is required for cued and contextual fear conditioning memory responses in aging mice.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31763496
 
 
|keywords=* Fear conditioning
* SIRT1
* aging
* classically conditioned memory
* hippocampus
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6839599
}}
{{medline-entry
|title=Does education level protect us from rapid ageing? Sirtuin expression versus age and level of education.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31785216
 
|mesh-terms=* Adolescent
* Adult
* Age Factors
* Aging
* Aging, Premature
* Educational Status
* Epigenesis, Genetic
* Female
* Gene Expression Regulation, Enzymologic
* Histones
* Humans
* Learning
* Male
* Middle Aged
* Sirtuins
* Young Adult
 
 
}}
{{medline-entry
|title=CO ameliorates endothelial senescence induced by 5-fluorouracil through [[SIRT1]] activation.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31704100
 
|mesh-terms=* Antioxidants
* Carbon Monoxide
* Cellular Senescence
* Down-Regulation
* Fluorouracil
* Heme Oxygenase-1
* Human Umbilical Vein Endothelial Cells
* Humans
* Nitric Oxide Synthase Type III
* Reactive Oxygen Species
* Sirtuin 1
|keywords=* 5-Fluorouracil
* Carbon monoxide
* Endothelial senescence
* Reactive oxygen species
* SIRT1
|full-text-url=https://sci-hub.do/10.1016/j.abb.2019.108185
}}
{{medline-entry
|title=Long noncoding RNA GAS5 inhibits cell proliferation and fibrosis in diabetic nephropathy by sponging miR-221 and modulating [[SIRT1]] expression.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31631065
 
|mesh-terms=* Aging
* Animals
* Argonaute Proteins
* Cell Proliferation
* Diabetes Mellitus, Experimental
* Diabetic Nephropathies
* Fibrosis
* Gene Deletion
* Gene Expression Regulation
* Glucose
* Male
* Mesangial Cells
* Mice
* MicroRNAs
* RAW 264.7 Cells
* RNA, Long Noncoding
* Rats
* Rats, Sprague-Dawley
* Sirtuin 1
|keywords=* diabetic nephropathy
* fibrosis
* lncRNA GAS5
* proliferation
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6834398
}}
{{medline-entry
|title=The Role of Sirtuin1 in Regulating Endothelial Function, Arterial Remodeling and Vascular Aging.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31572218
 
 
|keywords=* PVAT
* SIRT1
* eNOS
* vascular aging
* vascular remodeling
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6751260
}}
{{medline-entry
|title=Deacetylation of LAMP1 drives lipophagy-dependent generation of free fatty acids by Abrus agglutinin to promote senescence in prostate cancer.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31544977
 
 
|keywords=* Abrus agglutinin
* LAMP1
* SIRT1
* free fatty acid
* lipophagy
* reactive oxygen species
* senescence
|full-text-url=https://sci-hub.do/10.1002/jcp.29182
}}
{{medline-entry
|title=Plasma exosomes in OSA patients promote endothelial senescence: effect of long-term adherent continuous positive airway pressure.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31552414
 
 
|keywords=* CPAP
* OSA
* aging
* cardiovascular
* endothelium
* exosomes
* extracellular vesicles
* intermittent hypoxia
* oxidative stress
* senescence
|full-text-url=https://sci-hub.do/10.1093/sleep/zsz217
}}
{{medline-entry
|title=Hydrogen Sulfide Inhibits High Glucose-Induced Neuronal Senescence by Improving Autophagic Flux [i]via[/i] Up-regulation of [[SIRT1]].
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31481873
 
 
|keywords=* SIRT1
* autophagic flux
* high glucose
* hydrogen sulfide
* neuronal senescence
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6710442
}}
{{medline-entry
|title=Activation of the miR-34a-Mediated [[SIRT1]]/mTOR Signaling Pathway by Urolithin A Attenuates D-Galactose-Induced Brain Aging in Mice.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31420820
 
|mesh-terms=* Aging
* Animals
* Brain
* Coumarins
* Galactose
* Male
* Mice
* Mice, Inbred ICR
* MicroRNAs
* PC12 Cells
* Random Allocation
* Rats
* Signal Transduction
* Sirtuin 1
* TOR Serine-Threonine Kinases
|keywords=* D-Gal
* SIRT1/mTOR signal pathway
* Urolithin A
* aging
* autophagy
* miR-34a
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6985387
}}
==SIRT2==
 
{{medline-entry
|title=Melatonin ameliorates the advanced maternal age-associated meiotic defects in oocytes through the [[SIRT2]]-dependent H4K16 deacetylation pathway.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31980591
 
 
|keywords=* aging
* histone acetylation
* meiosis
* melatonin
* oocyte quality
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7053624
}}
==SIRT3==
 
{{medline-entry
|title=[[SIRT3]] protects endothelial cells from high glucose-induced senescence and dysfunction via the p53 pathway.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/33160987
 
 
|keywords=* Endothelial senescence
* High glucose
* SIRT3
* p53
|full-text-url=https://sci-hub.do/10.1016/j.lfs.2020.118724
}}
{{medline-entry
|title=Melatonin and Sirtuins in Buccal Epithelium: Potential Biomarkers of Aging and Age-Related Pathologies.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/33143333
 
 
|keywords=* aging
* arterial hypertension
* buccal epithelium
* melatonin
* sirtuins
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7662974
}}
{{medline-entry
|title=[i][[SIRT3]][/i] Transfection of Aged Human Bone Marrow-Derived Mesenchymal Stem Cells Improves Cell Therapy-Mediated Myocardial Repair.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32228121
 
 
|keywords=* O-hMSC transplantation
* SIRT3
* aging
* gene modification
* myocardial infarction
* myocardial repair
|full-text-url=https://sci-hub.do/10.1089/rej.2019.2260
}}
{{medline-entry
|title=17β-estradiol inhibits H O -induced senescence in HUVEC cells through upregulating [[SIRT3]] expression and promoting autophagy.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32172411
 
 
|keywords=* 17β-estradiol
* Autophagy
* SIRT3
* Senescence
|full-text-url=https://sci-hub.do/10.1007/s10522-020-09868-w
}}
{{medline-entry
|title=CR6 interacting factor 1 deficiency induces premature senescence via [[SIRT3]] inhibition in endothelial cells.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32109515
 
 
|keywords=* Antioxidant system
* Mitochondria
* Oxidative stress
* Senescence
* Vascular endothelial cell
|full-text-url=https://sci-hub.do/10.1016/j.freeradbiomed.2020.02.017
}}
{{medline-entry
|title=Mitochondrial function in skeletal myofibers is controlled by a TRF2-[[SIRT3]] axis over lifetime.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31991048
 
 
|keywords=* aging
* mitochondria
* postmitotic cells
* skeletal muscle
* telomeres
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7059141
}}
{{medline-entry
|title=Context-Dependent Roles for SIRT2 and [[SIRT3]] in Tumor Development Upon Calorie Restriction or High Fat Diet.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31970087
 
 
|keywords=* SIRT2
* SIRT3
* aging
* calorie restriction
* cancer
* high fat diet
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6960403
}}
{{medline-entry
|title=The yin and yang faces of the mitochondrial deacetylase sirtuin 3 in age-related disorders.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31740222
 
|mesh-terms=* Aging
* Animals
* Cardiovascular Diseases
* Humans
* Metabolic Diseases
* Mitochondria
* Neurodegenerative Diseases
* Protein Isoforms
* Sirtuin 3
|keywords=* Age-related diseases
* Deacetylation
* Genetic manipulations
* Mitochondria
* Pharmacological modulators
* Sirtuins
|full-text-url=https://sci-hub.do/10.1016/j.arr.2019.100983
}}
==SIRT5==
 
{{medline-entry
|title=Lysine malonylation and propionylation are prevalent in human lens proteins.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31678036
 
|mesh-terms=* Aging
* Animals
* Blotting, Western
* Chromatography, Liquid
* Crystallins
* Cytoskeletal Proteins
* Cytosol
* Epithelial Cells
* Humans
* Immunohistochemistry
* Lens, Crystalline
* Lysine
* Malonates
* Membrane Proteins
* Mice, Inbred C57BL
* Mice, Knockout
* Middle Aged
* Mitochondrial Proteins
* Organ Culture Techniques
* Paraffin Embedding
* Propionates
* Sirtuin 3
* Sirtuins
* Tandem Mass Spectrometry
|keywords=* Lens proteins
* Malonylation
* Mass spectrometry
* Propionylation
* Sirtuins
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6957740
}}
==SIRT6==
 
{{medline-entry
|title=Association between [[SIRT6]] Methylation and Human Longevity in a Chinese Population.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/33238266
 
 
|keywords=* DNA Methylation
* Longevity
* Messenger RNA
* SIRT6
|full-text-url=https://sci-hub.do/10.1159/000508832
}}
{{medline-entry
|title=The [[SIRT6]] activator MDL-800 improves genomic stability and pluripotency of old murine-derived iPS cells.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/33089974
 
 
|keywords=* DNA repair
* MDL-800
* SIRT6
* aging
* genome integrity
* pluripotency
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7431819
}}
{{medline-entry
|title=Sirtuins as Possible Predictors of Aging and Alzheimer's Disease Development: Verification in the Hippocampus and Saliva.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/33098511
 
 
|keywords=* Alzheimer’s disease
* aging
* intravital diagnosis
* saliva
* sirtuins
|full-text-url=https://sci-hub.do/10.1007/s10517-020-04986-4
}}
{{medline-entry
|title=Age-related epigenetic drift deregulates [i][[SIRT6]][/i] expression and affects its downstream genes in human peripheral blood mononuclear cells.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32573339
 
 
|keywords=* SIRT6
* aging
* interaction network
* longevity
* methylation
* miRNA
* peripheral blood mononuclear cells (PBMCs)
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7678931
}}
{{medline-entry
|title=Biological and catalytic functions of sirtuin 6 as targets for small-molecule modulators.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32518153
 
 
|keywords=* SIRT6
* activator
* aging
* cancer
* cell metabolism
* chromatin
* gene expression
* histone deacetylase (HDAC)
* longevity
* metabolic disorder
* sirtuin
* small molecule
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7415977
}}
{{medline-entry
|title=Age-dependent role of [[SIRT6]] in jawbone via regulating senescence and autophagy of bone marrow stromal cells.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32002721
 
|mesh-terms=* Adult
* Aged
* Aging
* Animals
* Bone Marrow Cells
* Humans
* Jaw
* Male
* Mesenchymal Stem Cells
* Mice
* Mice, Knockout
* Middle Aged
* Osteogenesis
* Sirtuins
|keywords=* Autophagy
* Bone marrow stromal cells
* Jawbone
* Osteoporosis
* SIRT6
* Senescence
|full-text-url=https://sci-hub.do/10.1007/s10735-020-09857-w
}}
{{medline-entry
|title=Mechanism of activation for the sirtuin 6 protein deacylase.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31822559
 
|mesh-terms=* Allosteric Regulation
* Biocatalysis
* Fatty Acids
* HEK293 Cells
* Histones
* Humans
* Hydrophobic and Hydrophilic Interactions
* Kinetics
* Lipids
* Mutagenesis
* Mutation
* NAD
* Peptides
* Protein Binding
* Protein Conformation
* Sirtuins
* Small Molecule Libraries
|keywords=* SIRT6
* activator
* cancer
* chromatin
* deacetylation
* epigenetics
* histone
* histone deacetylase (HDAC)
* lifespan
* long chain acyl substrate
* longevity
* sirtuin
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6996886
}}
{{medline-entry
|title=Proteomics of Long-Lived Mammals.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31737995
 
 
|keywords=* SIRT6
* aging
* long-lived mammals
* naked mole rats
* proteomics
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7117992
}}
{{medline-entry
|title=Sirtuins and [[SIRT6]] in Carcinogenesis and in Diet.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31591350
 
|mesh-terms=* Aging
* Animals
* Carcinogenesis
* Diet
* Gene Expression Regulation, Neoplastic
* Humans
* Nanomedicine
* Organ Specificity
* Sirtuins
|keywords=* SIRT6
* cancer
* chemotherapy
* diet
* modulator
* sirtuins
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6801518
}}
{{medline-entry
|title=[[SIRT6]]-mediated transcriptional suppression of MALAT1 is a key mechanism for endothelial to mesenchymal transition.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31399301
 
|mesh-terms=* Aging
* Animals
* Cells, Cultured
* Disease Models, Animal
* Endothelium, Vascular
* Epithelial-Mesenchymal Transition
* Gene Expression Regulation
* Male
* Mice
* Mice, Inbred C57BL
* Mice, Knockout
* RNA, Long Noncoding
* Signal Transduction
* Sirtuins
* Vascular Diseases
 
|full-text-url=https://sci-hub.do/10.1016/j.ijcard.2019.07.082
}}
==SIRT7==
 
{{medline-entry
|title=[[SIRT7]] antagonizes human stem cell aging as a heterochromatin stabilizer.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32504224
 
 
|keywords=* LINE1
* SIRT7
* STING
* aging
* cGAS
* stem cell
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7305295
}}
==SLA==
 
{{medline-entry
|title=Vaccination of aged mice with adjuvanted recombinant influenza nucleoprotein enhances protective immunity.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32540272
 
 
|keywords=* Adjuvant
* Aging
* Influenza
* Mouse
* Nucleoprotein
* Vaccination
|full-text-url=https://sci-hub.do/10.1016/j.vaccine.2020.05.085
}}
{{medline-entry
|title=Mechanical Anisotropy and Surface Roughness in Additively Manufactured Parts Fabricated by Stereolithography ([[SLA]]) Using Statistical Analysis.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32486137
 
 
|keywords=* Taguchi methods
* additive manufacturing
* aging effect
* analysis of variance
* anisotropy
* design of experiments
* stereolithography
* surface roughness
* tensile testing
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7321476
}}
{{medline-entry
|title=The Effect of Age of Titanium Dental Implants on Implant Survival and Marginal Bone Resorption: A 5-Year Retrospective Follow-Up Study.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32369581
 
 
|keywords=*
         
            aged implant
         
       
*
         
            biological aging
         
       
*
         
            implant survival
         
       
*
         
            marginal bone resorption
         
       
*
         
            titanium dental implant
         
       
|full-text-url=https://sci-hub.do/10.1563/aaid-joi-D-19-00316
}}
==SLC16A7==
 
{{medline-entry
|title=Genetics of facial telangiectasia in the Rotterdam Study: a genome-wide association study and candidate gene approach.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/33095951
 
 
|keywords=* GWAS
* KIAA0930
* MC1R
* SLCA45A2
* SNP
* Telangiectasia
* candidate gene approach
* epidemiology
* genetics
* pigmentation genes
* red veins
* skin aging
|full-text-url=https://sci-hub.do/10.1111/jdv.17014
}}
==SLC26A2==
 
{{medline-entry
|title=Phenotypic characterization of Slc26a2 mutant mice reveals a multifactorial etiology of spondylolysis.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31914611
 
|mesh-terms=* Aging
* Animals
* Lumbar Vertebrae
* Male
* Mice
* Osteogenesis
* Phenotype
* Spondylolysis
* Sulfate Transporters
|keywords=* SLC26A2
* bone loss
* isthmic defect
* spondylolysis
* vertebral development
|full-text-url=https://sci-hub.do/10.1096/fj.201901040RR
}}
==SLC6A4==
 
{{medline-entry
|title=The Psilocybin-Telomere Hypothesis: An empirically falsifiable prediction concerning the beneficial neuropsychopharmacological effects of psilocybin on genetic aging.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31634774
 
|mesh-terms=* Aging
* Aging, Premature
* Animals
* Anxiety
* Brain-Derived Neurotrophic Factor
* Consciousness
* DNA Methylation
* Depression
* Disease Models, Animal
* Endocrine System
* Humans
* Models, Genetic
* Models, Psychological
* Neurotransmitter Agents
* Oxidative Stress
* Personality
* Psilocybin
* Psychotropic Drugs
* Research Design
* Serotonin Plasma Membrane Transport Proteins
* Stress, Psychological
* Telomere Shortening
|keywords=* Cellular senescence
* Depression
* Epigenetic clock
* Genetic aging
* Life extension
* Neurophenomenology
* Psilocybin
* Rejuvenation
* Rumination
* Senotherapy
* Telomeres
|full-text-url=https://sci-hub.do/10.1016/j.mehy.2019.109406
}}
==SMAD1==
 
{{medline-entry
|title=TGFB1-Mediated Gliosis in Multiple Sclerosis Spinal Cords Is Favored by the Regionalized Expression of HOXA5 and the Age-Dependent Decline in Androgen Receptor Ligands.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31779094
 
|mesh-terms=* Age Factors
* Aged
* Aging
* Brain
* Data Mining
* Databases, Genetic
* Disease Progression
* Female
* Gene Expression Profiling
* Gliosis
* Homeodomain Proteins
* Humans
* Ligands
* Male
* Middle Aged
* Multiple Sclerosis
* Proteomics
* Receptors, Androgen
* Sequence Analysis, RNA
* Signal Transduction
* Smad1 Protein
* Spinal Cord
* Transforming Growth Factor beta1
* Up-Regulation
|keywords=* androgen receptor
* astrocytes
* homeobox A5
* multiple sclerosis
* spinal cord
* transforming growth factor beta 1
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6928867
}}
==SMAD2==
 
{{medline-entry
|title=Prostate epithelial-specific expression of activated PI3K drives stromal collagen production and accumulation.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31674011
 
|mesh-terms=* Aging
* Animals
* Class I Phosphatidylinositol 3-Kinases
* Collagen
* Disease Models, Animal
* Disease Progression
* Epithelium
* Male
* Mice, Mutant Strains
* Phosphorylation
* Prostate
* Prostatic Hyperplasia
* Prostatic Intraepithelial Neoplasia
* Prostatic Neoplasms
* Signal Transduction
* Smad2 Protein
* Stromal Cells
* Transforming Growth Factor beta
|keywords=* PIK3CA
* cancer
* collagen
* fibrosis
* mouse model
* prostate
* stroma
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7071816
}}
==SMAD3==
 
{{medline-entry
|title=Sirtuin 6 deficiency transcriptionally up-regulates TGF-β signaling and induces fibrosis in mice.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31744885
 
|mesh-terms=* Aging
* Animals
* Fibroblasts
* Fibrosis
* Gene Deletion
* Male
* Mice
* Myocardium
* Myofibroblasts
* Signal Transduction
* Sirtuins
* Smad3 Protein
* Transcriptional Activation
* Transforming Growth Factor beta
|keywords=* SIRT6 deacetylase
* SMAD transcription factor
* SMAD3
* TGF-beta signaling
* aging
* aging-associated fibrosis
* caloric restriction
* cardiac disease
* extracellular matrix (ECM)
* fibrosis
* sirtuin
* transforming growth factor beta (TGF-beta)
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6956532
}}
==SMN2==
 
{{medline-entry
|title=Age-dependent SMN expression in disease-relevant tissue and implications for SMA treatment.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31589162
 
|mesh-terms=* Aging
* Autopsy
* Cell Survival
* Female
* Humans
* Male
* Motor Neurons
* Muscular Atrophy, Spinal
* Oligodeoxyribonucleotides, Antisense
* Spinal Cord
* Survival of Motor Neuron 2 Protein
|keywords=* Development
* Neurodegeneration
* Neurodevelopment
* Neuromuscular disease
* Neuroscience
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6819103
}}
==SMS==
 
{{medline-entry
|title=Does a Live Performance Impact Synchronization to Musical Rhythm in Cognitively Impaired Elderly?
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/33104027
 
 
|keywords=* Aging
* Alzheimer’s disease
* cognitive impairment
* dementia
* motor activity
* music therapy
* social interaction
|full-text-url=https://sci-hub.do/10.3233/JAD-200521
}}
{{medline-entry
|title=Testing the effectiveness of physical activity advice delivered via text messaging vs. human phone advisors in a Latino population: The On The Move randomized controlled trial design and methods.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32659437
 
 
|keywords=* Aging
* Digital health
* Latino
* Physical activity
* Text-messaging
* mHealth
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7351675
}}
==SNAP25==
 
{{medline-entry
|title=The Biological Foundations of Sarcopenia: Established and Promising Markers.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31457015
 
 
|keywords=* SNAP25
* aging
* biomarkers
* neuromuscular junction
* sarcopenia
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6700259
}}
==SNCA==
 
{{medline-entry
|title=Behavioural and dopaminergic changes in double mutated human A30P*A53T alpha-synuclein transgenic mouse model of Parkinson´s disease.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31758049
 
|mesh-terms=* Aging
* Alanine
* Amino Acid Substitution
* Animals
* Behavior, Animal
* Disease Models, Animal
* Dopaminergic Neurons
* Humans
* Locomotion
* Male
* Mice
* Mice, Inbred C57BL
* Mice, Transgenic
* Mutation, Missense
* Parkinson Disease
* Proline
* Threonine
* alpha-Synuclein
 
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6874660
}}
==SND1==
 
{{medline-entry
|title=[Downregulation of [[SND1]] Expression Accelerates Cell Senescence of Human Diploid Fibroblasts 2BS via Modulating the SASP].
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32543144
 
|mesh-terms=* Cellular Senescence
* Diploidy
* Down-Regulation
* Endonucleases
* Fibroblasts
* Humans
* Nuclear Proteins
|keywords=* Aging
* Cellular senescent
* SND1
* Senescence-associated-secretory-phenotype
|full-text-url=https://sci-hub.do/10.12182/20200560504
}}
==SOD1==
 
{{medline-entry
|title=[[SOD1]], more than just an antioxidant.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/33259795
 
 
|keywords=* Aging
* Cancer
* Neurodegenerative diseases
* Post-translational modifications
* Superoxide dismutase 1
|full-text-url=https://sci-hub.do/10.1016/j.abb.2020.108701
}}
{{medline-entry
|title=The Exacerbation of Aging and Oxidative Stress in the Epididymis of [i]Sod1[/i] Null Mice.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32054065
 
 
|keywords=* 4-hydroxynonenal
* 8-hydroxyguanosine
* aging
* epididymis
* oxidative stress
* reactive oxygen species
* spermatozoa
* superoxide dismutase
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7071042
}}
{{medline-entry
|title=Alterations in lipid metabolism of spinal cord linked to amyotrophic lateral sclerosis.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31406145
 
|mesh-terms=* Aging
* Amyotrophic Lateral Sclerosis
* Animals
* Cardiolipins
* Cholesterol Esters
* Disease Models, Animal
* Disease Progression
* Fatty Acids, Unsaturated
* Female
* Humans
* Lipid Droplets
* Lipid Metabolism
* Lipidomics
* Male
* Mass Spectrometry
* Motor Cortex
* Motor Neurons
* Mutation
* Oxidative Stress
* Rats
* Rats, Transgenic
* Spinal Cord
* Superoxide Dismutase-1
 
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6691112
}}
==SOD2==
 
{{medline-entry
|title=Astaxanthin Counteracts Vascular Calcification In Vitro Through an Early Up-Regulation of [[SOD2]] Based on a Transcriptomic Approach.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/33198315
 
 
|keywords=* aortic calcification
* astaxanthin
* chronic kidney disease
* chronic kidney disease-mineral bone disorder
* oxidative stress
* reactive oxygen species
* senescence
* vascular calcification
* vascular smooth muscle cells
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7698184
}}
{{medline-entry
|title=Alginate Oligosaccharide Prevents against D-galactose-mediated Cataract in C57BL/6J Mice via Regulating Oxidative Stress and Antioxidant System.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/33153341
 
 
|keywords=* Cataract
* D-galactose
* aging
* alginate oligosaccharide
* oxidative stress
|full-text-url=https://sci-hub.do/10.1080/02713683.2020.1842456
}}
{{medline-entry
|title=Protoflavones in melanoma therapy: Prooxidant and pro-senescence effect of protoapigenone and its synthetic alkyl derivative in A375 cells.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32931795
 
|mesh-terms=* Antineoplastic Agents, Phytogenic
* Autophagy
* Biomarkers
* Cell Cycle
* Cell Line, Tumor
* Cellular Senescence
* Cyclohexanones
* Flavones
* Humans
* Melanoma
* Reactive Oxygen Species
* Superoxide Dismutase
* beta-Galactosidase
|keywords=* Alkyl protoflavone
* Flavonoid
* Melanoma
* Protoapigenone
* Semi-synthesis
* Senescence
|full-text-url=https://sci-hub.do/10.1016/j.lfs.2020.118419
}}
{{medline-entry
|title=Ginsenoside Rg1 protects against Sca-1  HSC/HPC cell aging by regulating the SIRT1-FOXO3 and SIRT3-[[SOD2]] signaling pathways in a γ-ray irradiation-induced aging mice model.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32765665
 
 
|keywords=* SIRT1
* SIRT3
* aging
* ginsenoside Rg1
* hematopoietic progenitor cells
* hematopoietic stem cells
* senescence
* γ-ray irradiation
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7388550
}}
{{medline-entry
|title=Almond Skin Extracts and Chlorogenic Acid Delay Chronological Aging and Enhanced Oxidative Stress Response in Yeast.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32481725
 
 
|keywords=* 8-Oxo-guanine
* aging
* almond
* chlorogenic acid
* lipid peroxidation
* mitochondria
* oxidative stress
* protein carbonylation
* sirtuin
* superoxide dismutase
* yeast
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7345664
}}
{{medline-entry
|title=Opposing p53 and mTOR/AKT promote an in vivo switch from apoptosis to senescence upon telomere shortening in zebrafish.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32427102
 
 
|keywords=* AKT
* aging
* apoptosis
* cell biology
* p53
* regenerative medicine
* senescence
* stem cells
* telomeres
* zebrafish
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7237213
}}
{{medline-entry
|title=Bioactive peptides derived from crimson snapper and in vivo anti-aging effects on fat diet-induced high fat Drosophila melanogaster.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31844865
 
|mesh-terms=* Aging
* Animal Scales
* Animals
* Catalase
* Diet, High-Fat
* Disease Models, Animal
* Drosophila Proteins
* Drosophila melanogaster
* Female
* Fish Proteins
* Fishes
* Humans
* Longevity
* Male
* Malondialdehyde
* Oxidative Stress
* Peptides
* Superoxide Dismutase
 
|full-text-url=https://sci-hub.do/10.1039/c9fo01414d
}}
{{medline-entry
|title=Ellagic acid prolongs the lifespan of Drosophila melanogaster.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31786733
 
 
|keywords=* Drosophila melanogaster
* Ellagic acid
* Gene expression
* Longevity
* Stress
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7031466
}}
{{medline-entry
|title=Chlorella vulgaris modulates the expression of senescence-associated genes in replicative senescence of human diploid fibroblasts.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31642042
 
|mesh-terms=* Antioxidants
* Catalase
* Cell Differentiation
* Cell Proliferation
* Cells, Cultured
* Cellular Senescence
* Chlorella vulgaris
* DNA Damage
* Diploidy
* Fibroblasts
* Gene Expression
* Genes, p53
* Humans
* Male
* Mitogen-Activated Protein Kinase 14
* Molecular Chaperones
* Primary Cell Culture
* Signal Transduction
* Superoxide Dismutase
* Superoxide Dismutase-1
|keywords=* Chlorella vulgaris
* Fibroblasts
* Replicative senescence
* Senescence-associated genes
|full-text-url=https://sci-hub.do/10.1007/s11033-019-05140-8
}}
{{medline-entry
|title=Age-Associated Changes in Antioxidants and Redox Proteins of Rat Heart.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31647296
 
|mesh-terms=* Aging
* Animals
* Antioxidants
* Glutathione Peroxidase
* Male
* Myocardium
* Oxidation-Reduction
* Rats
* Rats, Wistar
* Superoxide Dismutase
 
|full-text-url=https://sci-hub.do/10.33549/physiolres.934170
}}
{{medline-entry
|title=Impact of curcumin on replicative and chronological aging in the Saccharomyces cerevisiae yeast.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31659616
 
 
|keywords=* Aging
* Curcumin
* Hypertrophy
* Oxidative stress
* Yeast
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6942599
}}
==SOX13==
 
{{medline-entry
|title=In silico analysis of human renin gene-gene interactions and neighborhood topologically associated domains suggests breakdown of insulators contribute to ageing-associated diseases.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31520345
 
|mesh-terms=* Aging
* Computer Simulation
* Epistasis, Genetic
* Humans
* Promoter Regions, Genetic
* Renin
|keywords=* Aging
* Diseases of aging
* Gene expression
* Gene–gene interaction
* Genomics
* Longevity
* Renin-angiotensin system
* Topologically associated domains
|full-text-url=https://sci-hub.do/10.1007/s10522-019-09834-1
}}
==SOX2==
 
{{medline-entry
|title=Multiple nanosecond pulsed electric fields stimulation with conductive poly(l-lactic acid)/carbon nanotubes films maintains the multipotency of mesenchymal stem cells during prolonged in vitro culture.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32592324
 
 
|keywords=* cell physical stimulus
* differentiation
* mesenchymal stem cells
* multipotency
* nanosecond pulsed electric fields
* senescence
|full-text-url=https://sci-hub.do/10.1002/term.3088
}}
{{medline-entry
|title=Subpopulations of miniature pig mesenchymal stromal cells with different differentiation potentials differ in the expression of octamer-binding transcription factor 4 and sex determining region Y-box 2.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32054231
 
 
|keywords=* Aging
* Mesenchymal Stromal Cell (MSC) Subpopulations
* Miniature Pig
* Octamerbinding Transcription Factor 4 (OCT4)
* Sex Determining Region Y-box 2 (SOX2)
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7054621
}}
{{medline-entry
|title=Increased Type I and Decreased Type II Hair Cells after Deletion of Sox2 in the Developing Mouse Utricle.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31678344
 
|mesh-terms=* Aging
* Animals
* Cell Count
* Cell Differentiation
* Cell Lineage
* Hair Cells, Vestibular
* Mice
* Mice, Knockout
* Mice, Transgenic
* SOXB1 Transcription Factors
* Saccule and Utricle
|keywords=* SOX2
* balance disorder
* hair cell
* utricle
* vestibule
|full-text-url=https://sci-hub.do/10.1016/j.neuroscience.2019.09.027
}}
==SOX4==
 
{{medline-entry
|title=Age-induced accumulation of methylmalonic acid promotes tumour progression.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32814897
 
|mesh-terms=* Adult
* Aged
* Aging
* Animals
* Cell Line, Tumor
* Disease Progression
* Female
* Gene Expression Regulation, Neoplastic
* Humans
* Male
* Methylmalonic Acid
* Mice
* Middle Aged
* Neoplasm Invasiveness
* Neoplasm Metastasis
* Neoplasms
* SOXC Transcription Factors
* Signal Transduction
* Transcriptome
* Transforming Growth Factor beta
 
|full-text-url=https://sci-hub.do/10.1038/s41586-020-2630-0
}}
==SOX9==
 
{{medline-entry
|title=Positive Effects of a Young Systemic Environment and High Growth Differentiation Factor 11 Levels on Chondrocyte Proliferation and Cartilage Matrix Synthesis in Old Mice.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32067417
 
|mesh-terms=* Adolescent
* Aged
* Aging
* Animals
* Arthroplasty, Replacement, Knee
* Bone Morphogenetic Proteins
* Cartilage, Articular
* Cell Proliferation
* Chondrocytes
* Collagen Type II
* Collagen Type X
* Core Binding Factor Alpha 1 Subunit
* Extracellular Matrix
* Female
* Growth Differentiation Factors
* Humans
* In Vitro Techniques
* Knee Joint
* Male
* Matrix Metalloproteinase 13
* Mice
* Osteoarthritis, Knee
* Parabiosis
* Phosphorylation
* RNA, Messenger
* Reverse Transcriptase Polymerase Chain Reaction
* SOX9 Transcription Factor
* Smad2 Protein
* Smad3 Protein
* Stifle
* Young Adult
 
|full-text-url=https://sci-hub.do/10.1002/art.41230
}}
==SPARC==
 
{{medline-entry
|title=[[SPARC]] Metrics Provide Mobility Smoothness Assessment in Oldest-Old With and Without a History of Falls: A Case Control Study.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32587523
 
 
|keywords=* aging
* falls
* functional mobility
* movement smoothness
* oldest-old
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7298141
}}
{{medline-entry
|title=Reduced fibrillar collagen accumulation in skeletal muscle of secreted protein acidic and rich in cysteine ([[SPARC]])-null mice.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31582603
 
|mesh-terms=* Aging
* Animals
* Fibrillar Collagens
* Gene Expression
* Male
* Mice
* Mice, Knockout
* Muscle, Skeletal
* Myofibrils
* Osteonectin
|keywords=* Secreted protein acidic and rich in cysteine
* collagen
* fibrosis
* myofiber
* skeletal muscle
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6895640
}}
==SPR==
 
{{medline-entry
|title=Regulation of lifespan by neural excitation and REST.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31619788
 
|mesh-terms=* Aging
* Animals
* Brain
* Caenorhabditis elegans
* Caenorhabditis elegans Proteins
* DNA-Binding Proteins
* Forkhead Transcription Factors
* Humans
* Longevity
* Mice
* Mice, 129 Strain
* Mice, Inbred C57BL
* Mice, Knockout
* Mice, Transgenic
* Neurons
* RNA Interference
* RNA-Binding Proteins
* Repressor Proteins
* Transcription Factors
 
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6893853
}}
==SPRTN==
 
{{medline-entry
|title=Tandem Deubiquitination and Acetylation of [[SPRTN]] Promotes DNA-Protein Crosslink Repair and Protects against Aging.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32649882
 
|mesh-terms=* Acetylation
* Aging
* Animals
* Cell Line
* DNA Damage
* DNA Repair
* DNA-Binding Proteins
* Deubiquitinating Enzymes
* Endopeptidases
* Female
* Genomic Instability
* HEK293 Cells
* Humans
* Male
* Mice, Inbred C57BL
* Mice, Knockout
* Phosphorylation
* Protein Domains
* Protein Processing, Post-Translational
* Ubiquitination
|keywords=* DNA repair
* DNA-protein crosslink
* SPRTN
* Top1cc
* VCPIP1/VCIP135
* acetylation
* aging
* genomic instability
* metalloprotease
* ubiquitination
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7484104
}}
==SPRY1==
 
{{medline-entry
|title=Sprouty1 Prevents Cellular Senescence Maintaining Proliferation and Differentiation Capacity of Human Adipose Stem/Progenitor Cells.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32304210
 
 
|keywords=* Adipogenesis
* Adipose stem cell
* Obesity
* Senescence
* Sprouty1
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7662188
}}
{{medline-entry
|title=Mechanism of [[SPRY1]] methylation regulating natural aging of skin epidermal cells.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31483543
 
 
|keywords=* SPRY1
* methylation
* natural aging
* skin epidermal aging
|full-text-url=https://sci-hub.do/10.1111/jocd.13126
}}
==SQSTM1==
 
{{medline-entry
|title=The selective autophagy receptor [[SQSTM1]]/p62 improves lifespan and proteostasis in an evolutionarily conserved manner.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32041473
 
 
|keywords=* Aging
* C. elegans
* Drosophila
* SQST-1
* SQSTM1
* aggrephagy
* heat shock
* mitophagy
* p62
* proteostasis
* ref(2)P
* selective autophagy
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7138197
}}
==SRC==
 
{{medline-entry
|title=Metabolic characteristics of CD8  T cell subsets in young and aged individuals are not predictive of functionality.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32504069
 
|mesh-terms=* Adult
* Aged
* Aging
* Animals
* CD8-Positive T-Lymphocytes
* Cell Differentiation
* Cell Proliferation
* Disease Models, Animal
* Female
* Humans
* Immunologic Memory
* Influenza A virus
* Influenza, Human
* Male
* Mice
* Microscopy, Electron, Transmission
* Mitochondria
* T-Lymphocyte Subsets
* Young Adult
 
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7275080
}}
==SRD5A2==
 
{{medline-entry
|title=Extract of Plumbago zeylanica enhances the growth of hair follicle dermal papilla cells with down-regulation of 5α-reductase type II.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32125089
 
 
|keywords=*
P zeylanica
 
* 5α-reductase
* dermal papilla
* hair
* plumbagin
* senescence
|full-text-url=https://sci-hub.do/10.1111/jocd.13355
}}
==SRF==
 
{{medline-entry
|title=Changes in snail and [[SRF]] expression in the kidneys of diabetic rats during ageing.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31668740
 
|mesh-terms=* Aging
* Animals
* Diabetes Mellitus, Experimental
* Diabetic Nephropathies
* Gene Expression Regulation
* Kidney
* Male
* Rats
* Rats, Sprague-Dawley
* Snail Family Transcription Factors
* Transcription Factors
|keywords=* Diabetic nephropathy
* Renal fibrosis
* SRF
* Snail
|full-text-url=https://sci-hub.do/10.1016/j.acthis.2019.151460
}}
{{medline-entry
|title=Mechanosensitive transcriptional coactivators MRTF-A and YAP/TAZ regulate nucleus pulposus cell phenotype through cell shape.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31638828
 
|mesh-terms=* Actins
* Adaptor Proteins, Signal Transducing
* Aging
* Biomechanical Phenomena
* Cells, Cultured
* Cytoskeleton
* Gene Expression Regulation
* Humans
* Hydrogels
* Intervertebral Disc Degeneration
* Nucleus Pulposus
* RNA Interference
* Trans-Activators
* Transcription Factors
* rho-Associated Kinases
|keywords=* F-actin
* SRF
* TEAD
* intervertebral disc
* mechanotransduction
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6894097
}}
==SRL==
 
{{medline-entry
|title=Income dividends and subjective survival in a Cherokee Indian cohort: a quasi-experiment.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32432936
 
|mesh-terms=* Adult
* Aged
* Aged, 80 and over
* Cohort Studies
* Female
* Humans
* Income
* Indians, South American
* Longevity
* Male
* Middle Aged
* North Carolina
* Social Class
* Surveys and Questionnaires
* Survival Analysis
 
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7250001
}}
==SRM==
 
{{medline-entry
|title=[Geriatric specificities of localized renal cell carcinoma].
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31771769
 
|mesh-terms=* Age Factors
* Aged
* Carcinoma, Renal Cell
* Geriatric Assessment
* Humans
* Kidney Neoplasms
|keywords=* Cancer du rein
* Diagnosis
* Diagnostic
* Elderly
* Geriatrics
* Gériatrie
* Personne âgée
* Petite masse rénale
* Renal cell carcinoma
* Small renal mass
* Traitement
* Treatment
|full-text-url=https://sci-hub.do/10.1016/j.purol.2019.08.281
}}
==SSB==
 
{{medline-entry
|title=Modelling the Effects of Beverage Substitution during Adolescence on Later Obesity Outcomes in Early Adulthood: Results from the Raine Study.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31816850
 
|mesh-terms=* Adolescent
* Adolescent Nutritional Physiological Phenomena
* Aging
* Humans
* Models, Biological
* Obesity
* Odds Ratio
* Risk Factors
* Sugar-Sweetened Beverages
* Young Adult
|keywords=* obesity
* substitution modelling
* sugar-sweetened beverages
* waist circumference
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6950484
}}
==SST==
 
{{medline-entry
|title=The distance to death perceptions of older adults explain why they age in place: A theoretical examination.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32972627
 
 
|keywords=* Agency- or belonging-related
* Distance to death, aging in place
* Emotions
* Residential mobility
* Socioemotional selectivity theory
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7489887
}}
{{medline-entry
|title=Population Segmentation Based on Healthcare Needs: Validation of a Brief Clinician-Administered Tool.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32607929
 
 
|keywords=* aging
* health services research
* psychometrics
|full-text-url=https://sci-hub.do/10.1007/s11606-020-05962-4
}}
{{medline-entry
|title=Examination on how emotion regulation mediates the relationship between future time perspective and well-being: a counter-evidence to the socioemotional selectivity theory.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32158369
 
 
|keywords=* Aging
* Emotion regulation
* Future time perspective
* Socioemotional selectivity theory
* Time left in life
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7040126
}}
==STAT1==
 
{{medline-entry
|title=[[STAT1]]-p53-p21axis-dependent stress-induced progression of chronic nephrosis in adriamycin-induced mouse model.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32953802
 
 
|keywords=* Adriamycin
* STAT1
* chronic nephrosis (CN)
* mitogen-activated protein kinase
* senescence
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7475511
}}
{{medline-entry
|title=Age-Dependent and -Independent Effects of Perivascular Adipose Tissue and Its Paracrine Activities during Neointima Formation.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31906225
 
|mesh-terms=* Adipose Tissue
* Aging
* Animals
* Carotid Arteries
* Carotid Artery Diseases
* Carotid Artery Injuries
* Humans
* Mice
* Mice, Mutant Strains
* Neointima
* Paracrine Communication
* STAT1 Transcription Factor
|keywords=* aging
* atherosclerosis
* neointima formation
* perivascular adipose tissue
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6981748
}}
{{medline-entry
|title=Legumain-deficient macrophages promote senescence of tumor cells by sustaining JAK1/[[STAT1]] activation.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31857155
 
|mesh-terms=* Animals
* Bone Marrow Transplantation
* Breast Neoplasms
* Cell Cycle Proteins
* Cell Line, Tumor
* Cellular Senescence
* Disease Models, Animal
* Female
* Gene Expression Regulation, Neoplastic
* Humans
* Integrin alphaVbeta3
* Interleukin-1beta
* Janus Kinase 1
* Macrophage Activation
* Macrophages
* Mice
* Mice, Knockout
* STAT1 Transcription Factor
* Signal Transduction
|keywords=* Cellular senescence
* Legumain
* M1 polarization
* Tumor-associated macrophage
|full-text-url=https://sci-hub.do/10.1016/j.canlet.2019.12.013
}}
==STAT3==
 
{{medline-entry
|title=Dietary Restriction Suppresses Steatosis-Associated Hepatic Tumorigenesis in Hepatitis C Virus Core Gene Transgenic Mice.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/33083279
 
 
|keywords=* Cyclin D1
* NF-κB
* STAT3
* Senescence
* p62/SQSTM1
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7548900
}}
{{medline-entry
|title=Skeletal glucocorticoid signalling determines leptin resistance and obesity in aging mice.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/33045434
 
 
|keywords=* Aging
* Appetite
* Glucocorticoid
* Leptin
* Obesity
* Osteoblast
* Osteocyte
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7596342
}}
{{medline-entry
|title=AMPK alleviates oxidative stress‑induced premature senescence via inhibition of NF-κB/[[STAT3]] axis-mediated positive feedback loop.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32882228
 
 
|keywords=* AMPK
* NF-κB/STAT3 signalling
* Oxidative stress
* SASP
* Senescence
|full-text-url=https://sci-hub.do/10.1016/j.mad.2020.111347
}}
{{medline-entry
|title=Age-related loss of neural stem cell O-GlcNAc promotes a glial fate switch through [[STAT3]] activation.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32848054
 
|mesh-terms=* Aging
* Animals
* Cell Differentiation
* Cell Proliferation
* Computational Biology
* Gene Expression Regulation
* Glucosamine
* Hippocampus
* Mice
* Neural Stem Cells
* Neurogenesis
* Neuroglia
* STAT3 Transcription Factor
* Sequence Analysis, RNA
|keywords=* O-GlcNAcylation
* aging
* gliogenesis
* neural stem cells
* neurogenesis
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7486730
}}
{{medline-entry
|title=Cell Death by Gallotannin Is Associated with Inhibition of the JAK/STAT Pathway in Human Colon Cancer Cells.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32714471
 
 
|keywords=* Apoptosis
* JAK/STAT
* caspase
* colon cancer
* gallotannin
* senescence
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7378856
}}
{{medline-entry
|title=The effect of interleukin 6 deficiency on myocardial signal transduction pathways activation induced by bacterial lipopolysaccharide in young and old mice.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32693349
 
 
|keywords=* Aging
* For review: bacterial lipolisacharide (LPS)
* Heart
* Inflammation
* Interleukin-6
* Signal transduction
|full-text-url=https://sci-hub.do/10.1016/j.advms.2020.06.006
}}
{{medline-entry
|title=Silibinin and SARS-CoV-2: Dual Targeting of Host Cytokine Storm and Virus Replication Machinery for Clinical Management of COVID-19 Patients.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32517353
 
 
|keywords=* IL-6
* JAK
* coronavirus
* cytokine storm
* remdesivir
* senescence
* stat3
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7356916
}}
{{medline-entry
|title=Implication of JAK1/[[STAT3]]/SOCS3 Pathway in Aging of Cerebellum of Male Rat: Histological and Molecular study.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32483368
 
|mesh-terms=* Aging
* Animals
* Caspase 3
* Cerebellum
* Glial Fibrillary Acidic Protein
* Glutathione
* Immunohistochemistry
* Janus Kinase 1
* Male
* Malondialdehyde
* Microscopy, Electron
* Rats
* Rats, Wistar
* STAT3 Transcription Factor
* Signal Transduction
* Suppressor of Cytokine Signaling 3 Protein
* Tumor Necrosis Factor-alpha
 
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7264275
}}
{{medline-entry
|title=Atorvastatin-induced senescence of hepatocellular carcinoma is mediated by downregulation of hTERT through the suppression of the IL-6/[[STAT3]] pathway.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32257389
 
 
|keywords=* Cancer therapy
* Senescence
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7105491
}}
{{medline-entry
|title=Deciphering the Molecular Mechanism of Spontaneous Senescence in Primary Epithelial Ovarian Cancer Cells.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32012719
 
 
|keywords=* aging biomarkers
* cancer biology
* cellular senescence
* epithelial ovarian cancer
* oxidative stress
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7072138
}}
{{medline-entry
|title=Persistent Activation of [[STAT3]] Pathway in the Retina Induced Vision Impairment and Retinal Degenerative Changes in Ageing Mice.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31884637
 
|mesh-terms=* Aging
* Animals
* Mice
* Mice, Inbred C57BL
* Retina
* Retinal Degeneration
* STAT3 Transcription Factor
* Suppressor of Cytokine Signaling 3 Protein
* Suppressor of Cytokine Signaling Proteins
* Uveitis
|keywords=* EAU
* Experimental autoimmune uveitis
* Retinal dystrophies
* SOCS3
* STAT3
* Transgenic mouse
* Uveitis
|full-text-url=https://sci-hub.do/10.1007/978-3-030-27378-1_58
}}
{{medline-entry
|title=Interleukin-10 induces senescence of activated hepatic stellate cells via [[STAT3]]-p53 pathway to attenuate liver fibrosis.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31730896
 
 
|keywords=* Hepatic stellate cells
* Interleukin-10
* Liver fibrosis
* Senescence
* Signal pathway
|full-text-url=https://sci-hub.do/10.1016/j.cellsig.2019.109445
}}
==STC2==
 
{{medline-entry
|title=Genome-wide Associations Reveal Human-Mouse Genetic Convergence and Modifiers of Myogenesis, CPNE1 and [[STC2]].
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31761296
 
|mesh-terms=* Adult
* Aged
* Aging
* Animals
* Body Composition
* Body Weight
* Calcium-Binding Proteins
* Case-Control Studies
* Female
* Follow-Up Studies
* Genome-Wide Association Study
* Glycoproteins
* Humans
* Intercellular Signaling Peptides and Proteins
* Male
* Mice
* Middle Aged
* Muscle Development
* Muscle, Skeletal
* Quantitative Trait Loci
* Thinness
|keywords=* UK Biobank
* human and mouse GWAS
* sarcopenia
* skeletal muscle
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6904802
}}
==STIM1==
 
{{medline-entry
|title=Progerin in muscle leads to thermogenic and metabolic defects via impaired calcium homeostasis.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31833196
 
|mesh-terms=* Animals
* Calcium
* Calnexin
* Cell Nucleus
* Disease Models, Animal
* Endoplasmic Reticulum
* Endoplasmic Reticulum Stress
* Lamin Type A
* Mice
* Mice, Knockout
* Microscopy, Electron, Transmission
* Muscle Proteins
* Muscle, Skeletal
* Muscular Dystrophies
* Mutation
* Myoblasts
* ORAI1 Protein
* Progeria
* Proteolipids
* Stromal Interaction Molecule 1
* Thermogenesis
* Up-Regulation
|keywords=* aging
* calcium homeostasis
* lamin A
* muscular dystrophy
* progeria
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6996945
}}
==STS==
 
{{medline-entry
|title=Delayed Impairment of Postural, Physical, and Muscular Functions Following Downhill Compared to Level Walking in Older People.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/33192547
 
 
|keywords=* aging
* balance
* falls
* fatigue
* functional performance
* muscle damage
* walking
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7609421
}}
{{medline-entry
|title=Autophagy displays divergent roles during intermittent amino acid starvation and toxic stress-induced senescence in cultured skeletal muscle cells.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/33022071
 
 
|keywords=* autophagy
* caspase
* cell death
* remodeling
* senescence
|full-text-url=https://sci-hub.do/10.1002/jcp.30079
}}
{{medline-entry
|title=The WRKY53 transcription factor enhances stilbene synthesis and disease resistance by interacting with MYB14 and MYB15 in Chinese wild grape.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32080737
 
 
|keywords=* Chinese wild grape (Vitis quinquangularis)
* WRKY transcription factor
* disease resistance
* leaf senescence
* stilbene
* transcriptional regulation
|full-text-url=https://sci-hub.do/10.1093/jxb/eraa097
}}
{{medline-entry
|title=On the role of ageing and musculoskeletal pain on dynamic balance in manual workers.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31733466
 
|mesh-terms=* Aged
* Aging
* Female
* Humans
* Male
* Middle Aged
* Muscle, Skeletal
* Musculoskeletal Pain
* Occupational Diseases
* Postural Balance
|keywords=* Discomfort
* Lower extremity function
* Posturography
* Sit-to-stand
|full-text-url=https://sci-hub.do/10.1016/j.jelekin.2019.102374
}}
==SUCNR1==
 
{{medline-entry
|title=[The effect of Mexidol on cerebral mitochondriogenesis at a young age and during aging].
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32105271
 
|mesh-terms=* Age Factors
* Aging
* Animals
* Male
* Mitochondria
* Neurodegenerative Diseases
* Picolines
* Rats
* Receptors, G-Protein-Coupled
* Transcription Factors
|keywords=* Western blot analysis
* aging
* cerebral mitochondriogenesis
* mexidol
* mitochondrial dysfunction
* rats
* respiratory enzyme subunits
* succinate receptor
* transcriptional coactivator PGC-1α
|full-text-url=https://sci-hub.do/10.17116/jnevro202012001162
}}
==SUGCT==
 
{{medline-entry
|title=Knockout of the non-essential gene [[SUGCT]] creates diet-linked, age-related microbiome disbalance with a diabetes-like metabolic syndrome phenotype.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31722069
 
|mesh-terms=* Aging
* Animals
* Anti-Bacterial Agents
* Bacteria
* Carnitine
* Coenzyme A-Transferases
* Dietary Supplements
* Feces
* Gastrointestinal Microbiome
* Humans
* Kidney
* Lipid Metabolism
* Liver
* Lysine
* Metabolic Syndrome
* Metabolome
* Mice
* Mice, Knockout
* Obesity
* Tryptophan
|keywords=* C7orf10
* Glutaric aciduria type 3 (GA3)
* Gut microflora
* Lipids
* Metabolomics
* Obesity
* Sugct
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7426296
}}
==SUV39H1==
 
{{medline-entry
|title=Increase in hippocampal histone H3K9me3 is negatively correlated with memory in old male mice.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31760560
 
 
|keywords=* Aging
* H3K9me3
* Hippocampus
* IEGs
* Memory
* SUV39H1
|full-text-url=https://sci-hub.do/10.1007/s10522-019-09850-1
}}
==SYK==
 
{{medline-entry
|title=miR-25-3p promotes endothelial cell angiogenesis in aging mice via TULA-2/[[SYK]]/VEGFR-2 downregulation.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/33201836
 
 
|keywords=* TULA-2
* aging
* angiogenesis
* endothelial cell
* miR-25-3p
|full-text-url=https://sci-hub.do/10.18632/aging.103834
}}
{{medline-entry
|title=Identification of [[SYK]] inhibitor, R406 as a novel senolytic agent.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32379705
 
 
|keywords=* FAK
* apoptosis
* cellular senescence
* p38
* senolytics
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7244031
}}
==SYNE1==
 
{{medline-entry
|title=Nesprin-1 impact on tumorigenic cell phenotypes.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31741263
 
|mesh-terms=* Actins
* Carcinogenesis
* Cell Line, Tumor
* Cell Nucleus
* Cytoskeletal Proteins
* Gene Expression
* Gene Expression Regulation, Neoplastic
* Humans
* Microfilament Proteins
* Nerve Tissue Proteins
* Nuclear Envelope
* Phenotype
|keywords=* Cancer
* Cellular senescence
* Genome stability
* Nesprin-1
* Nuclear envelope
|full-text-url=https://sci-hub.do/10.1007/s11033-019-05184-w
}}
==TAAR1==
 
{{medline-entry
|title=Minimal Age-Related Alterations in Behavioral and Hematological Parameters in Trace Amine-Associated Receptor 1 ([[TAAR1]]) Knockout Mice.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31399838
 
|mesh-terms=* Age Factors
* Animals
* Anxiety
* Dose-Response Relationship, Drug
* Male
* Mice
* Mice, 129 Strain
* Mice, Inbred C57BL
* Mice, Knockout
* Receptors, G-Protein-Coupled
* Sodium Chloride
|keywords=* Aging
* Anxiety
* Hematology
* Leukocytes
* Neutrophils
* TAAR1
* Thyroid
* Trace amines
|full-text-url=https://sci-hub.do/10.1007/s10571-019-00721-4
}}
==TAS2R16==
 
{{medline-entry
|title=Taste receptor polymorphisms and longevity: a systematic review and meta-analysis.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/33170488
 
 
|keywords=* Immune-inflammatory responses
* Longevity
* Meta-analysis
* Taste receptors
|full-text-url=https://sci-hub.do/10.1007/s40520-020-01745-3
}}
==TAS2R38==
 
{{medline-entry
|title=[[TAS2R38]] bitter taste receptor and attainment of exceptional longevity.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31792278
 
|mesh-terms=* Adolescent
* Adult
* Aged
* Aged, 80 and over
* Case-Control Studies
* Female
* Food Preferences
* Gene Frequency
* Genetic Variation
* Haplotypes
* Humans
* Longevity
* Male
* Middle Aged
* Receptors, G-Protein-Coupled
* Taste
* Taste Perception
* Young Adult
 
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6889489
}}
==TAZ==
 
{{medline-entry
|title=Transcriptional Coactivator [[TAZ]] Negatively Regulates Tumor Suppressor p53 Activity and Cellular Senescence.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31936650
 
 
|keywords=* TAZ
* cellular senescence
* oncogene
* p300
* p53
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7016652
}}
==TBC1D5==
 
{{medline-entry
|title=[[TBC1D5]]-Catalyzed Cycling of Rab7 Is Required for Retromer-Mediated Human Papillomavirus Trafficking during Virus Entry.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32521275
 
 
|keywords=* HPV
* Rab7B
* TBC1D5
* functional genetics screen
* proximity ligation assay
* retrograde
* retromer
* senescence
* traptamer
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7339955
}}
{{medline-entry
|title=Retromer and [[TBC1D5]] maintain late endosomal RAB7 domains to enable amino acid-induced mTORC1 signaling.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31431476
 
|mesh-terms=* Animals
* Caenorhabditis elegans
* Caenorhabditis elegans Proteins
* Longevity
* Mechanistic Target of Rapamycin Complex 1
* Membrane Microdomains
* Signal Transduction
* rab GTP-Binding Proteins
 
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6719456
}}
==TBK1==
 
{{medline-entry
|title=Parkin overexpression alleviates cardiac aging through facilitating K63-polyubiquitination of [[TBK1]] to facilitate mitophagy.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/33164878
 
 
|keywords=* Aging
* K63-linked polyubiquitination
* Mitophagy
* Parkin
* TBK1
|full-text-url=https://sci-hub.do/10.1016/j.bbadis.2020.165997
}}
==TCF7L2==
 
{{medline-entry
|title=A myelin-related transcriptomic profile is shared by Pitt-Hopkins syndrome models and human autism spectrum disorder.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32015540
 
|mesh-terms=* Aging
* Animals
* Autism Spectrum Disorder
* Cell Count
* DNA Fingerprinting
* Facies
* Gene Expression Regulation
* Humans
* Hyperventilation
* Intellectual Disability
* Methyl-CpG-Binding Protein 2
* Mice
* Mice, Knockout
* Myelin Sheath
* Oligodendroglia
* PTEN Phosphohydrolase
* Primary Cell Culture
* Signal Transduction
* Transcription Factor 4
* Transcriptome
 
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7065955
}}
==TEC==
 
{{medline-entry
|title=Vestibular function and cortical and sub-cortical alterations in an aging population.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32904672
 
 
|keywords=* Aging
* Cognition
* Diffeomorphometry
* Epidemiology
* Eye-ear-nose-throat
* MRI
* Medical imaging
* Shape
* Vestibular
* Volume
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7457317
}}
{{medline-entry
|title=Metabolic Flexibility and Innate Immunity in Renal Ischemia Reperfusion Injury: The Fine Balance Between Adaptive Repair and Tissue Degeneration.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32733450
 
 
|keywords=* cell death
* innate immunity
* kidney transplantation
* mitochondria
* senescence
* tubular repair
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7358591
}}
{{medline-entry
|title=Postnatal Involution and Counter-Involution of the Thymus.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32477366
 
 
|keywords=* Myc
* aging
* cyclin D1
* growth
* involution
* thymus
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7235445
}}
{{medline-entry
|title=Gender Disparity Impacts on Thymus Aging and LHRH Receptor Antagonist-Induced Thymic Reconstitution Following Chemotherapeutic Damage.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32194555
 
 
|keywords=* aging
* chemotherapy
* gender
* luteinizing hormone-releasing hormone
* regeneration
* sex hormone deprivation
* thymic epithelial cell
* thymus
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7062683
}}
{{medline-entry
|title=Clonogenic Culture of Mouse Thymic Epithelial Cells.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31396938
 
|mesh-terms=* Aging
* Animals
* Cell Differentiation
* Cell Line
* Coculture Techniques
* Colony-Forming Units Assay
* DNA-Binding Proteins
* Epithelial Cells
* Flow Cytometry
* Fluorescent Antibody Technique, Direct
* Fluorescent Dyes
* Immunomagnetic Separation
* Mice
* Mice, Knockout
* Primary Cell Culture
* Rhodamines
* Self Tolerance
* Staining and Labeling
* Stem Cells
* Thymus Gland
|keywords=* Clonogenic assay
* Thymic epithelial cells
* Thymic epithelial stem cells
* Thymus
|full-text-url=https://sci-hub.do/10.1007/978-1-4939-9728-2_15
}}
==TEF==
 
{{medline-entry
|title=Expression of human HSP27 in yeast extends replicative lifespan and uncovers a hormetic response.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32189112
 
 
|keywords=* Aging
* Cancer
* HSP27
* Hormesis
* Neurodegeneratve diseases
* Proteasome
|full-text-url=https://sci-hub.do/10.1007/s10522-020-09869-9
}}
==TERT==
 
{{medline-entry
|title=Telomeres and telomerase in risk assessment of cardiovascular diseases.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/33171154
 
 
|keywords=* Cardiovascular diseases
* Senescence
* Telomerase
* Telomeres
|full-text-url=https://sci-hub.do/10.1016/j.yexcr.2020.112361
}}
{{medline-entry
|title=A 4-Base-Pair Core-Enclosing Helix in Telomerase RNA Is Essential for Activity and for Binding to the Telomerase Reverse Transcriptase Catalytic Protein Subunit.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/33046533
 
 
|keywords=* RNA
* RNP
* TERT
* TLC1
* senescence
* telomerase
* telomerase RNA
* telomere
* two-hybrid screening
* yeast
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7685517
}}
{{medline-entry
|title=Angiotensin inhibition and cellular senescence in the developing rat kidney.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/33010296
 
 
|keywords=* Apoptosis
* Cellular senescence
* Fetal development
* Kidney
* Renin-angiotensin system
|full-text-url=https://sci-hub.do/10.1016/j.yexmp.2020.104551
}}
{{medline-entry
|title=Decreased expression of [[TERT]] and telomeric proteins as human ovaries age may cause telomere shortening.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32856217
 
 
|keywords=* Ovarian aging
* TERT
* Telomere
* Telomere-binding proteins
|full-text-url=https://sci-hub.do/10.1007/s10815-020-01932-1
}}
{{medline-entry
|title=The secrets of telomerase: Retrospective analysis and future prospects.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32698073
 
|mesh-terms=* Aging
* Animals
* Diabetes Mellitus
* Humans
* Neoplasms
* Telomerase
* Telomere Shortening
|keywords=* Cancers
* G-quadruplex formation
* Metabolic disorders
* TERT gene
* Telomere-telomerase system
|full-text-url=https://sci-hub.do/10.1016/j.lfs.2020.118115
}}
{{medline-entry
|title=Gene expression in human mesenchymal stem cell aging cultures: modulation by short peptides.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32399807
 
 
|keywords=* Cell aging
* Genes
* Human mesenchymal stem cells
* Short peptides
|full-text-url=https://sci-hub.do/10.1007/s11033-020-05506-3
}}
{{medline-entry
|title=Unravelling Cellular Mechanisms of Stem Cell Senescence: An Aid from Natural Bioactive Molecules.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32244882
 
 
|keywords=* cellular mechanisms
* gene expression
* nutraceuticals
* oxidative stress
* senescence
* stem cells
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7150900
}}
{{medline-entry
|title=Expression of telomerase reverse transcriptase positively correlates with duration of lithium treatment in bipolar disorder.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32114208
 
|mesh-terms=* Adult
* Aging
* Antimanic Agents
* Bipolar Disorder
* Cellular Senescence
* Female
* Humans
* Lithium
* Lithium Compounds
* Male
* Middle Aged
* Mitochondria
* Oxidative Stress
* Polymorphism, Single Nucleotide
* Real-Time Polymerase Chain Reaction
* Telomerase
* Telomere
* Telomere Homeostasis
* Telomere Shortening
|keywords=* Affective disorder
* Aging
* Mitochondria
* Oxidative stress
* TERT
* Telomere
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7334059
}}
{{medline-entry
|title=FAM96B inhibits the senescence of dental pulp stem cells.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32039527
 
 
|keywords=* FAM96B
* aging
* dental pulp stem cells (DPSCs)
* proteomic analysis
|full-text-url=https://sci-hub.do/10.1002/cbin.11319
}}
{{medline-entry
|title=Aging and biomarkers: Transcriptional levels evaluation of Osteopontin/miRNA-181a axis in hepatic tissue of rats in different age ranges.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32061643
 
 
|keywords=* Aging
* Long non-coding RNA
* Osteopontin
* Telomeres
* miRNA
|full-text-url=https://sci-hub.do/10.1016/j.exger.2020.110879
}}
{{medline-entry
|title=Resveratrol inhibits adipocyte differentiation and cellular senescence of human bone marrow stromal stem cells.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31978617
 
 
|keywords=* Adipogenesis
* Antioxidant
* Bone marrow adiposity
* Bone marrow skeletal stromal cells
* Cellular senescence
* Osteogenesis
|full-text-url=https://sci-hub.do/10.1016/j.bone.2020.115252
}}
{{medline-entry
|title=Characterization of human telomerase reverse transcriptase immortalized anterior cruciate ligament cell lines.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31948601
 
|mesh-terms=* Adolescent
* Aged
* Anterior Cruciate Ligament
* Cell Differentiation
* Cell Separation
* Cells, Cultured
* Humans
* Mesenchymal Stem Cells
* Telomerase
|keywords=* Anterior cruciate ligament
* Immortalization
* Mesenchymal stem cells
* Multilineage differentiation
* Senescence
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6962762
}}
{{medline-entry
|title=Mitochondria, Telomeres and Telomerase Subunits.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31781563
 
 
|keywords=* TERC
* TERT
* aging
* mitochondria
* telomerase
* telomere
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6851022
}}
{{medline-entry
|title=Towards Therapeutic Alternatives for Mercury Neurotoxicity in the Amazon: Unraveling the Pre-Clinical Effects of the Superfruit Açaí ([i]Euterpe oleracea[/i], Mart.) as Juice for Human Consumption.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31717801
 
|mesh-terms=* Animals
* Antioxidants
* Behavior, Animal
* Brain Chemistry
* Euterpe
* Fruit and Vegetable Juices
* Lipid Peroxidation
* Male
* Mercury
* Mice
* Motor Skills
* Neurotoxins
* Plant Extracts
* Telomere
|keywords=* Euterpe
* acai
* aging
* antioxidant
* açaí
* extract
* intoxication
* methylmercury
* telomere
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6893510
}}
{{medline-entry
|title=Replication Stress at Telomeric and Mitochondrial DNA: Common Origins and Consequences on Ageing.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31597307
 
|mesh-terms=* Aging
* Animals
* Cellular Senescence
* DNA Damage
* DNA Replication
* DNA, Mitochondrial
* Epigenesis, Genetic
* Humans
* Mitochondria
* Oxidative Stress
* Stress, Physiological
* Telomere
* Telomere Homeostasis
* Telomere Shortening
|keywords=* G-quadruplex
* R-loop
* ageing
* helicase
* mitochondria
* replication stress
* senescence
* telomere
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6801922
}}
{{medline-entry
|title=Telomerase Biology Associations Offer Keys to Cancer and Aging Therapeutics.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31544708
 
 
|keywords=* Aging
* TERT
* associates
* cancer
* cell cycle
* diseases
* oncogenes
* viral infection.
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7403649
}}
{{medline-entry
|title=Transient induction of telomerase expression mediates senescence and reduces tumorigenesis in primary fibroblasts.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31481614
 
|mesh-terms=* Animals
* Cell Cycle
* Cell Transformation, Neoplastic
* Cells, Cultured
* Cellular Senescence
* Fibroblasts
* Gene Expression
* Gene Expression Regulation
* Gene Knockdown Techniques
* Humans
* Mice
* Mice, Inbred C57BL
* Mice, Knockout
* Phenotype
* Telomerase
* Telomere
|keywords=* ATM
* senescence
* telomerase
* tumorigenesis
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6754593
}}
==TET2==
 
{{medline-entry
|title=Non-coding and Loss-of-Function Coding Variants in [[TET2]] are Associated with Multiple Neurodegenerative Diseases.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32330418
 
|mesh-terms=* Aged
* Aged, 80 and over
* Alzheimer Disease
* Animals
* Cognition
* DNA-Binding Proteins
* Female
* Frontotemporal Dementia
* Humans
* Loss of Function Mutation
* Male
* Mice
* Neurodegenerative Diseases
* Proto-Oncogene Proteins
|keywords=* AD
* ALS
* Alzheimer
* FTD
* TET2
* aging
* amyotrophic lateral sclerosis
* frontotemporal dementia
* genome sequencing
* non-coding
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7212268
}}
{{medline-entry
|title=60 Years of clonal hematopoiesis research: From X-chromosome inactivation studies to the identification of driver mutations.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32001340
 
|mesh-terms=* Adult
* Aging
* Biomedical Research
* Chromosomes, Human, X
* DNA-Binding Proteins
* Female
* Hematopoiesis
* Hematopoietic Stem Cells
* History, 20th Century
* History, 21st Century
* Humans
* Male
* Mutation
* Proto-Oncogene Proteins
* Receptors, Androgen
* Repressor Proteins
* X Chromosome Inactivation
 
|full-text-url=https://sci-hub.do/10.1016/j.exphem.2020.01.008
}}
{{medline-entry
|title=DNA methylation instability by BRAF-mediated TET silencing and lifestyle-exposure divides colon cancer pathways.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31842975
 
|mesh-terms=* Animals
* Caco-2 Cells
* Cell Line, Tumor
* Colonic Neoplasms
* DNA Methylation
* DNA-Binding Proteins
* Down-Regulation
* Epigenesis, Genetic
* Female
* Gene Regulatory Networks
* HT29 Cells
* Humans
* Male
* Mice
* Mixed Function Oxygenases
* Mutation
* Neoplasms, Experimental
* Proto-Oncogene Proteins
* Proto-Oncogene Proteins B-raf
|keywords=* Aging
* BRAF V600E
* CIMP
* Colon cancer
* DNA methylation
* TET
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6916434
}}
{{medline-entry
|title=Clonal haematopoiesis: connecting ageing and inflammation in cardiovascular disease.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31406340
 
|mesh-terms=* Adult
* Age Factors
* Aged
* Aged, 80 and over
* Aging
* Animals
* Cardiovascular Diseases
* DNA (Cytosine-5-)-Methyltransferases
* DNA-Binding Proteins
* Genetic Predisposition to Disease
* Hematopoiesis
* Hematopoietic Stem Cells
* Humans
* Inflammation
* Middle Aged
* Mutation
* Phenotype
* Proto-Oncogene Proteins
* Repressor Proteins
* Risk Assessment
* Risk Factors
 
|full-text-url=https://sci-hub.do/10.1038/s41569-019-0247-5
}}
==TF==
 
{{medline-entry
|title=A preliminary investigation of the contribution of different tenderness factors to beef loin, tri-tip and heel tenderness.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32736289
 
 
|keywords=* Aging
* Beef
* Collagen
* Tenderness
* Trained panel
|full-text-url=https://sci-hub.do/10.1016/j.meatsci.2020.108247
}}
{{medline-entry
|title=The transcription factor ZmNAC126 accelerates leaf senescence downstream of the ethylene signalling pathway in maize.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32430911
 
 
|keywords=* ZmNAC
* chlorophyll catabolic genes
* ethylene
* leaf senescence
* maize
|full-text-url=https://sci-hub.do/10.1111/pce.13803
}}
{{medline-entry
|title=Extensive transcriptome changes during seasonal leaf senescence in field-grown black cottonwood (Populus trichocarpa Nisqually-1).
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32313054
 
|mesh-terms=* Aging
* Gene Expression Profiling
* Gene Expression Regulation, Plant
* Genome, Plant
* Photosynthesis
* Plant Leaves
* Populus
* Seasons
* Transcription Factors
* Transcriptome
 
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7170949
}}
{{medline-entry
|title=Expression of Transferrin and Albumin in the Sperm-Storage Tubules of Japanese Quail and their Possible Involvement in Long-Term Sperm Storage.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32174770
 
 
|keywords=* Japanese quail
* albumin
* sperm longevity
* sperm storage tubules
* transferrin
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7063080
}}
{{medline-entry
|title=OsWRKY5 Promotes Rice Leaf Senescence via Senescence-Associated NAC and Abscisic Acid Biosynthesis Pathway.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31505875
 
|mesh-terms=* Abscisic Acid
* Chlorophyll
* Gene Expression Regulation, Plant
* Gene Knockdown Techniques
* Oryza
* Plant Leaves
* Plant Proteins
* Transcription Factors
|keywords=* NAC
* OsWRKY
* abscisic acid (ABA)
* leaf senescence
* rice
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6770167
}}
{{medline-entry
|title=BrTCP7 Transcription Factor Is Associated with MeJA-Promoted Leaf Senescence by Activating the Expression of [i]BrOPR3[/i] and [i]BrRCCR[/i].
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31416297
 
|mesh-terms=* Amino Acid Sequence
* Brassica
* Cellular Senescence
* Cyclopentanes
* Gene Expression Regulation, Plant
* Oxylipins
* Phenotype
* Phylogeny
* Plant Growth Regulators
* Plant Leaves
* Plant Proteins
* Promoter Regions, Genetic
* Protein Binding
* Transcription Factors
|keywords=* Chinese flowering cabbage
* JA
* leaf senescence
* transcriptional activation
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6719003
}}
{{medline-entry
|title=Activation of the Transcription of [i]BrGA20ox3[/i] by a BrTCP21 Transcription Factor Is Associated with Gibberellin-Delayed Leaf Senescence in Chinese Flowering Cabbage during Storage.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31398806
 
|mesh-terms=* Aging
* Base Sequence
* Brassica
* Food Preservation
* Gene Expression Regulation, Plant
* Gibberellins
* Phenotype
* Phylogeny
* Plant Leaves
* Plant Proteins
* Promoter Regions, Genetic
* Protein Binding
* Transcription Factors
|keywords=* Chinese flowering cabbage
* GA
* leaf senescence
* transcriptional activation
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6720506
}}
==TFEB==
 
{{medline-entry
|title=A Novel Lipofuscin-detecting Marker of Senescence Relates With Hypoxia, Dysregulated Autophagy and With Poor Prognosis in Non-small-cell-lung Cancer.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/33144423
 
 
|keywords=* Senescence
* autophagy
* glycolysis
* hypoxia
* lipofuscin
* lung cancer
|full-text-url=https://sci-hub.do/10.21873/invivo.12154
}}
{{medline-entry
|title=ESC-sEVs Rejuvenate Senescent Hippocampal NSCs by Activating Lysosomes to Improve Cognitive Dysfunction in Vascular Dementia.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32440476
 
 
|keywords=* embryonic stem cells derived small extracellular vesicles (ESC‐sEVs)
* hippocampal neural stem cells (HNSCs)
* lysosomes
* senescence
* vascular dementia
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7237844
}}
{{medline-entry
|title=Nitrative Stress-Related Autophagic Insufficiency Participates in Hyperhomocysteinemia-Induced Renal Aging.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32047576
 
|mesh-terms=* Aging
* Animals
* Autophagy
* Cells, Cultured
* Homocysteine
* Humans
* Hyperhomocysteinemia
* Kidney
* Kidney Diseases
* Male
* Metalloporphyrins
* Peroxynitrous Acid
* Rats
* Rats, Sprague-Dawley
 
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7007752
}}
{{medline-entry
|title=Polyamines reverse immune senescence via the translational control of autophagy.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31679458
 
|mesh-terms=* Aging
* Animals
* Autophagy
* Humans
* Lysosomes
* Polyamines
* Protein Processing, Post-Translational
* Spermidine
|keywords=* Aging
* B cells
* EIF5A
* TFEB
* autophagy
* hypusine
* spermidine
* translation
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6984486
}}
{{medline-entry
|title=Polyamines Control eIF5A Hypusination, [[TFEB]] Translation, and Autophagy to Reverse B Cell Senescence.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31474573
 
|mesh-terms=* Adaptive Immunity
* Age Factors
* Aging
* Animals
* Autophagy
* B-Lymphocytes
* Basic Helix-Loop-Helix Leucine Zipper Transcription Factors
* Cellular Senescence
* HEK293 Cells
* Humans
* Immunologic Memory
* Immunosenescence
* Jurkat Cells
* Mice
* Mice, Inbred C57BL
* Mice, Knockout
* NIH 3T3 Cells
* Peptide Initiation Factors
* Protein Processing, Post-Translational
* RNA-Binding Proteins
* Signal Transduction
* Spermidine
|keywords=* B cell
* TFEB
* aging
* autophagy
* eIF5A
* spermidine
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6863385
}}
==TFPI==
 
{{medline-entry
|title=Identification of cardiovascular health gene variants related to longevity in a Chinese population.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32897244
 
 
|keywords=* Chinese
* factor related to cardiovascular health (FCH)
* genetic variation
* lipid metabolism
* longevity
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7521493
}}
==TG==
 
{{medline-entry
|title=Inhibition of the alternative lengthening of telomeres pathway by subtelomeric sequences in Saccharomyces cerevisiae.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/33126043
 
 
|keywords=* Budding yeast
* Rad52
* Replicative senescence
* Subtelomeric Y’ elements
* Telomerase-independent telomere maintenance
* Telomere recombination
|full-text-url=https://sci-hub.do/10.1016/j.dnarep.2020.102996
}}
{{medline-entry
|title=E4orf1, an Adeno-viral protein, attenuates renal lipid accumulation in high fat fed mice: A novel approach to reduce a key risk factor for chronic kidney disease.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/33102865
 
 
|keywords=* Aging
* CKD
* Diabetes
* Diet
* E4orf1
* FA synthesis
* Hyperinsulinemia
* Insulin
* Lipid metabolism
* Obesity
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7575883
}}
{{medline-entry
|title=Resistance exercise attenuates postprandial metabolic responses to a high-fat meal similarly in younger and older men.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/33032071
 
 
|keywords=* Aging
* Cardiometabolic
* Lipemia
* Metabolism
* Nutrition
|full-text-url=https://sci-hub.do/10.1016/j.nutres.2020.08.012
}}
{{medline-entry
|title=Aging-induced aberrant RAGE/PPARα axis promotes hepatic steatosis via dysfunctional mitochondrial β oxidation.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32936538
 
 
|keywords=* PPARα
* RAGE
* aging
* hepatic steatosis
* mitochondria
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7576254
}}
{{medline-entry
|title=Fenofibrate impairs liver function and structure more pronounced in old than young rats.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32927318
 
 
|keywords=* Aging
* Fenofibrate
* Lipids
* Liver function and morphology
* Rat
* serum
|full-text-url=https://sci-hub.do/10.1016/j.archger.2020.104244
}}
{{medline-entry
|title=Awareness of major cardiovascular risk factors and its relationship with markers of vascular aging: Data from the Brisighella Heart Study.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32249143
 
|mesh-terms=* Adolescent
* Adult
* Age Factors
* Aged
* Aged, 80 and over
* Aging
* Biomarkers
* Blood Glucose
* Blood Pressure
* Cardiovascular Diseases
* Cholesterol
* Cross-Sectional Studies
* Diabetes Mellitus
* Female
* Humans
* Hypercholesterolemia
* Hypertension
* Hypertriglyceridemia
* Italy
* Male
* Middle Aged
* Risk Assessment
* Risk Factors
* Triglycerides
* Vascular Stiffness
* Young Adult
|keywords=* Arterial aging
* Awareness
* Epidemiology
* Pulse wave velocity
* Risk factors
|full-text-url=https://sci-hub.do/10.1016/j.numecd.2020.03.005
}}
{{medline-entry
|title=Characterisation of the dynamic nature of lipids throughout the lifespan of genetically identical female and male Daphnia magna.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32221338
 
|mesh-terms=* Aging
* Animals
* Daphnia
* Diglycerides
* Female
* Lipid Metabolism
* Longevity
* Male
* Phosphatidylcholines
* Sphingomyelins
* Triglycerides
 
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7101400
}}
{{medline-entry
|title=Effects of laboratory biotic aging on the characteristics of biochar and its water-soluble organic products.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31472466
 
|mesh-terms=* Benzopyrans
* Charcoal
* Humic Substances
* Microbiota
* Soil Microbiology
* Solubility
* Triticum
* Water
|keywords=* Biochar
* Biotic incubation aging
* Dissolved organic matter (DOM)
* Excitation-emission matrix
* Humification
|full-text-url=https://sci-hub.do/10.1016/j.jhazmat.2019.121071
}}
{{medline-entry
|title=Using Caenorhabditis elegans for Studying Trans- and Multi-Generational Effects of Toxicants.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31403614
 
|mesh-terms=* Animals
* Caenorhabditis elegans
* Hazardous Substances
* Humans
* Longevity
* Reproduction
* Toxicity Tests
 
|full-text-url=https://sci-hub.do/10.3791/59367
}}
==TH==
 
{{medline-entry
|title=Thyroid hormone signaling is associated with physical performance, muscle mass, and strength in a cohort of oldest-old: results from the Mugello study.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/33219914
 
 
|keywords=* Aging
* Muscle mass
* Muscle strength
* Oldest-old
* Physical performance
* Rehabilitation
* Thyroid hormone signaling
|full-text-url=https://sci-hub.do/10.1007/s11357-020-00302-0
}}
{{medline-entry
|title=Social Environment Ameliorates Behavioral and Immune Impairments in Tyrosine Hydroxylase Haploinsufficient Female Mice.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32772235
 
 
|keywords=* Behavioral responses
* Immunosenescence
* Oxidative-inflammatory stress
* Social environmental strategy
* Tyrosine hydroxylase haploinsufficient mice
|full-text-url=https://sci-hub.do/10.1007/s11481-020-09947-2
}}
{{medline-entry
|title=Mechanism of thyroid hormone signaling in skeletal muscle of aging mice.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32720201
 
 
|keywords=* Aging
* Mice
* Skeletal muscle
* Thyroid hormone signaling
|full-text-url=https://sci-hub.do/10.1007/s12020-020-02428-9
}}
{{medline-entry
|title=Longitudinal changes in bone mineral density and trabecular bone score in Korean adults: a community-based prospective study.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32621253
 
|mesh-terms=* Absorptiometry, Photon
* Adult
* Bone Density
* Cancellous Bone
* Cohort Studies
* Female
* Humans
* Lumbar Vertebrae
* Male
* Prospective Studies
* Republic of Korea
|keywords=* Aging
* Bone mineral density
* Natural history
* Osteoporosis
|full-text-url=https://sci-hub.do/10.1007/s11657-020-00731-6
}}
{{medline-entry
|title=Quantitative proteomic profiling of the rat substantia nigra places glial fibrillary acidic protein at the hub of proteins dysregulated during aging: Implications for idiopathic Parkinson's disease.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32270889
 
 
|keywords=* RRID:AB_11145309
* RRID:AB_2109791
* RRID:AB_228307
* RRID:AB_228341
* RRID:AB_2336820
* RRID:AB_2631098
* RRID:AB_390204
* RRID:MGI:5651135
* RRID:SCR_001881
* RRID:SCR_002798
* RRID:SCR_003070
* RRID:SCR_004946
* RRID:SCR_005223
* aging
* dopaminergic neuron
* glial fibrillary acidic protein
* proteome
* proteomics
* substantia nigra
|full-text-url=https://sci-hub.do/10.1002/jnr.24622
}}
{{medline-entry
|title=Withaferin-A Protects the Nigral Dopamine Neuron and Recovers Motor Activity in Aged Rats.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31982873
 
|mesh-terms=* Aging
* Animals
* Brain
* Corpus Striatum
* Dopaminergic Neurons
* Male
* Motor Activity
* Neuroprotective Agents
* Rats
* Rats, Wistar
* Substantia Nigra
* Tyrosine 3-Monooxygenase
* Withanolides
|keywords=* Ageing
* Dopamine
* Striatum
* Substantia nigra
* Withaferin-A
|full-text-url=https://sci-hub.do/10.1159/000505183
}}
{{medline-entry
|title=Effects of physical activity on bone mineral density in older adults: Korea National Health and Nutrition Examination Survey, 2008-2011.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31655946
 
|mesh-terms=* Absorptiometry, Photon
* Aged
* Bone Density
* Cross-Sectional Studies
* Exercise
* Female
* Femur Neck
* Humans
* Lumbar Vertebrae
* Male
* Middle Aged
* Nutrition Surveys
* Osteoporosis
* Republic of Korea
* Surveys and Questionnaires
|keywords=* Aging
* Bone mineral density
* Exercise
* Gender
* Osteoporosis
* Physical activity
|full-text-url=https://sci-hub.do/10.1007/s11657-019-0655-5
}}
{{medline-entry
|title=Age-Related Resistance to Thyroid Hormone Action.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31512083
 
|mesh-terms=* Aged
* Aged, 80 and over
* Aging
* Animals
* Humans
* Hyperthyroidism
* Hypothyroidism
* Iodide Peroxidase
* Male
* Receptors, Thyroid Hormone
* Thyroid Hormones
* Thyroxine
* Triiodothyronine
 
|full-text-url=https://sci-hub.do/10.1007/s40266-019-00711-7
}}
{{medline-entry
|title=Age-Dependent Changes in Glucose Homeostasis in Male Deiodinase Type 2 Knockout Zebrafish.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31504428
 
|mesh-terms=* Aging
* Animals
* Animals, Genetically Modified
* Glucose
* Glucose Transport Proteins, Facilitative
* Homeostasis
* Hyperglycemia
* Iodide Peroxidase
* Islets of Langerhans
* Male
* Proglucagon
* Proinsulin
* Receptor, Insulin
* Receptors, Glucagon
* Zebrafish
 
|full-text-url=https://sci-hub.do/10.1210/en.2019-00445
}}
{{medline-entry
|title=Age effect on thyroid hormone brain response in male mice.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31494803
 
|mesh-terms=* Aging
* Animals
* Brain
* Gene Expression
* Hyperthyroidism
* Hypothyroidism
* Male
* Maze Learning
* Mice, Inbred C57BL
* Monocarboxylic Acid Transporters
* Organic Cation Transport Proteins
* Rotarod Performance Test
* Symporters
* Thyroid Hormones
* Thyrotropin
* Thyrotropin-Releasing Hormone
|keywords=* Ageing
* Hyperthyroidism
* Hypothyroidism
* Male mice
* Thyroid hormones
|full-text-url=https://sci-hub.do/10.1007/s12020-019-02078-6
}}
{{medline-entry
|title=Aging Is Associated with Low Thyroid State and Organ-Specific Sensitivity to Thyroxine.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31441387
 
|mesh-terms=* Aging
* Animals
* DNA-Binding Proteins
* Hypothalamo-Hypophyseal System
* Liver
* Male
* Mice
* Mice, Inbred C57BL
* Myocardium
* Pituitary Gland
* Thyroid Gland
* Thyroid Hormones
* Thyrotropin
* Thyroxine
* Transcription Factors
|keywords=* HPT-axis
* aging
* mice
* thyroid gland
* thyroid hormones
|full-text-url=https://sci-hub.do/10.1089/thy.2018.0377
}}
==TLR1==
 
{{medline-entry
|title=Effects of aging and lifelong aerobic exercise on expression of innate immune components in human skeletal muscle.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32969782
 
 
|keywords=* TLR
* aging
* innate immunity
* lifelong exercise
* skeletal muscle
|full-text-url=https://sci-hub.do/10.1152/japplphysiol.00615.2020
}}
{{medline-entry
|title=Association of TLR gene variants in a Czech Red Pied cattle population with reproductive traits.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31901560
 
|mesh-terms=* Age Factors
* Animals
* Breeding
* Cattle
* Czech Republic
* Female
* Genotype
* Longevity
* Male
* Phenotype
* Polymorphism, Single Nucleotide
* Reproduction
* Toll-Like Receptor 1
* Toll-Like Receptor 2
* Toll-Like Receptor 6
* Toll-Like Receptors
|keywords=* Cattle
* Diversity
* Effect prediction
* Health traits
* Toll-like receptors
|full-text-url=https://sci-hub.do/10.1016/j.vetimm.2019.109997
}}
==TLR2==
 
{{medline-entry
|title=Changes in salivary microbial sensing proteins CD14 and [[TLR2]] with aging.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32529494
 
|mesh-terms=* Adolescent
* Adult
* Aging
* Biomarkers
* Child
* Child, Preschool
* Humans
* Lipopolysaccharide Receptors
* Middle Aged
* Saliva
* Salivary Proteins and Peptides
* Toll-Like Receptor 2
* Young Adult
|keywords=* Age changes
* CD14
* Saliva
* Toll-like receptor-2
|full-text-url=https://sci-hub.do/10.1007/s00784-020-03274-9
}}
{{medline-entry
|title=Culture Model for Non-human Primate Choroid Plexus.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31555096
 
 
|keywords=* aging
* cell culture
* choroid plexus
* epithelial cell
* infectious disease
* rhesus macaque
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6724611
}}
==TLR4==
 
{{medline-entry
|title=Age-Dependent Changes of Adipokine and Cytokine Secretion From Rat Adipose Tissue by Endogenous and Exogenous Toll-Like Receptor Agonists.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32973755
 
 
|keywords=* adipokines
* aging
* batokines
* biglycan
* cytokines
* fat explant cultures
* high mobility group box-1 protein
* lipopolysaccharide
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7466552
}}
{{medline-entry
|title=Role of Toll Like Receptor 4 in Alzheimer's Disease.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32983082
 
 
|keywords=* Alzheimer’s disease
* TLR4
* aging
* amyloid beta oligomers
* calcium
* hippocampal neurons
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7479089
}}
{{medline-entry
|title=Commentary on Some Recent Theses Relevant to Combating Aging: August 2020.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32718230
 
 
|keywords=* aging
* dissertations
* theses
|full-text-url=https://sci-hub.do/10.1089/rej.2020.2378
}}
{{medline-entry
|title=Sialylation and Galectin-3 in Microglia-Mediated Neuroinflammation and Neurodegeneration.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32581723
 
 
|keywords=* aging
* desialylation
* galectin-3
* microglia
* neurodegeneration
* phagocytosis
* sialic acid
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7296093
}}
{{medline-entry
|title=Chemerin facilitates intervertebral disc degeneration via [[TLR4]] and CMKLR1 and activation of NF-kB signaling pathway.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32526705
 
 
|keywords=* chemerin
* inflammation
* intervertebral disc
* nucleus pulposus
* senescence
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7343479
}}
{{medline-entry
|title=Toll-like receptor 4 differentially regulates adult hippocampal neurogenesis in an age- and sex-dependent manner.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32343455
 
 
|keywords=* TLR4
* adult hippocampal neurogenesis
* aging
* proliferation
* sex differences
|full-text-url=https://sci-hub.do/10.1002/hipo.23209
}}
{{medline-entry
|title=Aging-associated immunosenescence via alterations in splenic immune cell populations in rat.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31838133
 
|mesh-terms=* Animals
* B-Lymphocytes
* Cells, Cultured
* Immunity, Cellular
* Immunosenescence
* Male
* Malondialdehyde
* Oxidative Stress
* Rats
* Rats, Wistar
* Spleen
* Superoxide Dismutase
* T-Lymphocytes
|keywords=* Aging
* Immunohistochemistry
* Immunosenescence
* Oxidative stress
* Spleen
|full-text-url=https://sci-hub.do/10.1016/j.lfs.2019.117168
}}
{{medline-entry
|title=Leptin induces immunosenescence in human B cells.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31831137
 
|mesh-terms=* Adult
* Aged
* B-Lymphocytes
* Humans
* Immunoglobulin Class Switching
* Immunosenescence
* Leptin
* Middle Aged
* Obesity
|keywords=* B cells
* Immunosenescence
* Leptin
* Obesity
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7002206
}}
{{medline-entry
|title=Genetic Variation in the Magnitude and Longevity of the IgG Subclass Response to a Diphtheria-Tetanus-Acellular Pertussis (DTaP) Vaccine in Mice.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31547158
 
 
|keywords=* DTaP
* IgG subclass
* antibody longevity
* antibody magnitude
* genetics
* vaccine
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6963843
}}
{{medline-entry
|title=Rapamycin improves sevoflurane‑induced cognitive dysfunction in aged rats by mediating autophagy through the [[TLR4]]/MyD88/NF‑κB signaling pathway.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31432123
 
|mesh-terms=* Aging
* Animals
* Autophagic Cell Death
* Cognitive Dysfunction
* Male
* Myeloid Differentiation Factor 88
* NF-kappa B
* Rats
* Rats, Sprague-Dawley
* Sevoflurane
* Signal Transduction
* Sirolimus
* Toll-Like Receptor 4
 
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6755174
}}
==TLR9==
 
{{medline-entry
|title=Age-Associated B Cells.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31986068
 
 
|keywords=* B lymphocytes
* aging
* autoimmunity
* memory B cells
|full-text-url=https://sci-hub.do/10.1146/annurev-immunol-092419-031130
}}
==TMEM106B==
 
{{medline-entry
|title=Genetics of Gene Expression in the Aging Human Brain Reveal TDP-43 Proteinopathy Pathophysiology.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32526197
 
|mesh-terms=* Aged
* Aged, 80 and over
* Aging
* Alzheimer Disease
* Amyloid beta-Peptides
* Apolipoproteins E
* Brain
* Cohort Studies
* DNA-Binding Proteins
* Female
* Gene Expression Regulation
* Haplotypes
* Humans
* Lysosomes
* Male
* Membrane Proteins
* Myelin Sheath
* Nerve Tissue Proteins
* Progranulins
* Quantitative Trait Loci
* RNA Splicing Factors
* TDP-43 Proteinopathies
|keywords=* Alzheimer's disease
* Amyloid-β
* GRN
* RBFOX1
* TDP-43
* TMEM106B
* co-expression module
* cognitive resilience
* eQTL
* expression quantitative trait loci
* sQTL
* splicing quantitative trait loci
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7416464
}}
==TMPRSS2==
 
{{medline-entry
|title=Susceptibility to COVID-19 in populations with health disparities: Posited involvement of mitochondrial disorder, socioeconomic stress, and pollutants.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32905655
 
 
|keywords=* SARS-CoV-2
* dysfunction
* exposome
* immunosenescence
* metabolomics
* mitochondria
* pollutant
* socioeconomic
* stress
|full-text-url=https://sci-hub.do/10.1002/jbt.22626
}}
{{medline-entry
|title=Expression of the SARS-CoV-2 Entry Proteins, ACE2 and [[TMPRSS2]], in Cells of the Olfactory Epithelium: Identification of Cell Types and Trends with Age.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32379417
 
|mesh-terms=* Age Factors
* Angiotensin-Converting Enzyme 2
* Animals
* Betacoronavirus
* COVID-19
* Coronavirus Infections
* Gene Expression
* Gene Expression Profiling
* Immunohistochemistry
* In Situ Hybridization
* Mice
* Olfaction Disorders
* Olfactory Mucosa
* Olfactory Receptor Neurons
* Pandemics
* Peptidyl-Dipeptidase A
* Pneumonia, Viral
* RNA-Seq
* Reverse Transcriptase Polymerase Chain Reaction
* SARS-CoV-2
* Serine Endopeptidases
* Virus Internalization
|keywords=* ACE2 expression
* COVID-19
* SARS-CoV-2
* aging
* anosmia
* olfactory epithelium
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7241737
}}
==TNC==
 
{{medline-entry
|title=Effects of Tenascin C on the Integrity of Extracellular Matrix and Skin Aging.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/33217999
 
 
|keywords=* TGF-β
* aging
* collagen
* extracellular matrix
* fibroblast
* skin
* tenascin C
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7698786
}}
{{medline-entry
|title=Tenascin-C expression controls the maturation of articular cartilage in mice.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32066496
 
|mesh-terms=* Aging
* Animals
* Cartilage, Articular
* Cell Count
* Genotype
* Mice
* Tenascin
|keywords=* Adhesion
* Articular cartilage
* Cartilage defect
* Cell density
* Knock-out mouse
* Load
* Tenascin C
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7027060
}}
{{medline-entry
|title=Effects of hydrothermal aging, thermal cycling, and water storage on the mechanical properties of a machinable resin-based composite containing nano-zirconia fillers.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31877525
 
 
|keywords=* Aging
* Mechanical properties
* Nano-zirconia
* Phase transformation
* Resin nano-ceramic
* Resin-based composite
|full-text-url=https://sci-hub.do/10.1016/j.jmbbm.2019.103522
}}
==TNF==
 
{{medline-entry
|title=Naringenin alleviates nonalcoholic steatohepatitis in middle-aged Apoe mice: role of SIRT1.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/33234364
 
 
|keywords=* AML-12 cells
* Aging
* ApoE(−/−) mice
* Naringenin
* Nonalcoholic steatohepatitis
* SIRT1
|full-text-url=https://sci-hub.do/10.1016/j.phymed.2020.153412
}}
{{medline-entry
|title=Protective role of microglial HO-1 blockade in aging: Implication of iron metabolism.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/33212416
 
 
|keywords=* Aging
* Ferroptosis
* Heme oxygenase-1
* Iron metabolism
* Microglia
* Neuroinflammation
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7680814
}}
{{medline-entry
|title=Anti-aging effect of DL-β-hydroxybutyrate against hepatic cellular senescence induced by D-galactose or γ-irradiation via autophagic flux stimulation in male rats.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/33147533
 
 
|keywords=* Autophagy
* D-galacose
* Ionizing radiation
* Senescence
* β-hydroxybutyric acid
|full-text-url=https://sci-hub.do/10.1016/j.archger.2020.104288
}}
{{medline-entry
|title=Exploring the extensive crosstalk between the antagonistic cytokines- TGF-β and [[TNF]]-α in regulating cancer pathogenesis.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/33153895
 
 
|keywords=* Apoptosis
* Autophagy
* EMT
* Fibrogenesis
* Senescence
* TGF-β and TNF-α
|full-text-url=https://sci-hub.do/10.1016/j.cyto.2020.155348
}}
{{medline-entry
|title=Long non-coding RNA SNHG29 regulates cell senescence via p53/p21 signaling in spontaneous preterm birth.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/33080448
 
 
|keywords=* Cellular senescence
* Oxidative stress
* SASP
* SNHG29
* Spontaneous preterm birth
* p53/p21
|full-text-url=https://sci-hub.do/10.1016/j.placenta.2020.10.009
}}
{{medline-entry
|title=Cognition Is Associated With Peripheral Immune Molecules in Healthy Older Adults: A Cross-Sectional Study.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32983153
 
 
|keywords=* chemokines
* cognition
* cytokines
* healthy aging
* immune molecules
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7493640
}}
{{medline-entry
|title=Anti-aging effects of [i]Ribes meyeri[/i] anthocyanins on neural stem cells and aging mice.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32920547
 
 
|keywords=* Ribes meyeri anthocyanin
* aging
* cognition
* naringenin
* senescence
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7521483
}}
{{medline-entry
|title=Effects of a four week detraining period on physical, metabolic, and inflammatory profiles of elderly women who regularly participate in a program of strength training.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32863968
 
 
|keywords=* Aging
* Inflammation
* Physical exercise
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7450596
}}
{{medline-entry
|title=Contribution of Porphyromonas gingivalis lipopolysaccharide to experimental periodontitis in relation to aging.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32851571
 
 
|keywords=* Aging
* Bone loss
* Osteoclastogenesis
* Periodontitis
* Porphyromonas gingivalis lipopolysaccharide
|full-text-url=https://sci-hub.do/10.1007/s11357-020-00258-1
}}
{{medline-entry
|title=New MoDC-Targeting [[TNF]] Fusion Proteins Enhance Cyclic Di-GMP Vaccine Adjuvanticity in Middle-Aged and Aged Mice.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32849581
 
 
|keywords=* 3′
* 5′-cyclic diguanylic acid (cyclic di-GMP)
* aging
* monocyte-derived dendritic cells (moDCs)
* tumor necrosis factor (TNF)
* vaccine
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7427090
}}
{{medline-entry
|title=Cognitive impairment in elderly patients with rheumatic disease and the effect of disease-modifying anti-rheumatic drugs.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32862311
 
 
|keywords=* Aging
* Biologics
* Cognition
* Rheumatic diseases
|full-text-url=https://sci-hub.do/10.1007/s10067-020-05372-1
}}
{{medline-entry
|title=Cotinine ameliorates memory and learning impairment in senescent mice.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32818583
 
 
|keywords=* Aging
* Cognitive impairment
* Cotinine
* Improvement
* α(7)nAChRs
|full-text-url=https://sci-hub.do/10.1016/j.brainresbull.2020.08.010
}}
{{medline-entry
|title=Kynurenines link chronic inflammation to functional decline and physical frailty.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32814718
 
 
|keywords=* Aging
* Cytokines
* Inflammation
* Neurodegeneration
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7455140
}}
{{medline-entry
|title=Voluntary exercise training attenuated the middle-aged maturity-induced cardiac apoptosis.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32781061
 
|mesh-terms=* Aging
* Animals
* Apoptosis
* Heart
* In Situ Nick-End Labeling
* Male
* Mice
* Mice, Inbred C57BL
* Mitochondria, Heart
* Muscle, Skeletal
* Physical Conditioning, Animal
* Running
* Sedentary Behavior
|keywords=* Caspase-independent
* Cell death
* Fas dependent
* IGF-related
* Mitochondrial
|full-text-url=https://sci-hub.do/10.1016/j.lfs.2020.118187
}}
{{medline-entry
|title=Preclinical Evaluation of a Food-Derived Functional Ingredient to Address Skeletal Muscle Atrophy.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32751276
 
 
|keywords=* aging
* bioactive
* functional ingredient
* immobilization
* inflammation
* muscle atrophy
* peptide
* protein synthesis
* skeletal muscle
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7469066
}}
{{medline-entry
|title=Childhood survivors of high-risk neuroblastoma show signs of immune recovery and not immunosenescence.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32744364
 
 
|keywords=* adverse late effects
* childhood
* immune recovery
* immunosenescence
* neuroblastoma
|full-text-url=https://sci-hub.do/10.1002/eji.202048541
}}
{{medline-entry
|title=FK506 induces lung lymphatic endothelial cell senescence and downregulates LYVE-1 expression, with associated decreased hyaluronan uptake.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32736525
 
 
|keywords=* Endothelial cells
* Fk506
* Hyaluronan
* LYVE-1
* Lung lymphatic
* Senescence
* TERT
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7395348
}}
{{medline-entry
|title=Late-onset hypogonadism: Reductio ad absurdum of the cardiovascular risk-benefit of testosterone replacement therapy.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32737921
 
 
|keywords=* aging
* androgen
* heart failure
* myocardial infarction
* testosterone
* thromboembolism
|full-text-url=https://sci-hub.do/10.1111/andr.12876
}}
{{medline-entry
|title=Doxorubicin generates senescent microglia that exhibit altered proteomes, higher levels of cytokine secretion, and a decreased ability to internalize amyloid β.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32738344
 
 
|keywords=* Aging
* Alzheimer's disease
* Inflammation
* Microglia
* Proteomics
* Senescence
|full-text-url=https://sci-hub.do/10.1016/j.yexcr.2020.112203
}}
{{medline-entry
|title=Time restricted feeding provides a viable alternative to alternate day fasting when evaluated in terms of redox homeostasis in rats.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32717588
 
 
|keywords=* Aging
* Alternate day fasting (ADF)
* Intermittent fasting (IF)
* Oxidative stress
* Time-Restricted feeding (TRF)
|full-text-url=https://sci-hub.do/10.1016/j.archger.2020.104188
}}
{{medline-entry
|title=Associations Between Plasma Immunomodulatory and Inflammatory Mediators With VACS Index Scores Among Older HIV-Infected Adults on Antiretroviral Therapy.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32695109
 
 
|keywords=* HIV
* aging
* anti-retroviral therapy
* inflammation
* morbidity
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7338430
}}
{{medline-entry
|title=Chrysin Impact on Oxidative and Inflammation Damages in the Liver of Aged Male Rats.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32679027
 
 
|keywords=* Aging
* chrysin
* inflammation
* liver
* oxidative stress
* rat.
|full-text-url=https://sci-hub.do/10.2174/1871530320666200717162304
}}
{{medline-entry
|title=Correction of immunosuppression in aged septic rats by human ghrelin and growth hormone through the vagus nerve-dependent inhibition of TGF-β production.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32677895
 
 
|keywords=* Aging
* Ghrelin
* Immunosuppression
* Sepsis
* Vagus nerve
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7364485
}}
{{medline-entry
|title=Epigenetics of neuroinflammation: Immune response, inflammatory response and cholinergic synaptic involvement evidenced by genome-wide DNA methylation analysis of delirious inpatients.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32590150
 
 
|keywords=* Aging
* Delirium
* Genome-wide DNA methylation
* Immune response
* Inflammatory response
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7486988
}}
{{medline-entry
|title=[i]Andrographis paniculata[/i] and Its Bioactive Diterpenoids Against Inflammation and Oxidative Stress in Keratinocytes.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32560449
 
 
|keywords=* Andrographis paniculata
* andrographolide
* inflammation
* keratinocytes
* oxidative stress
* skin aging
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7346124
}}
{{medline-entry
|title=Etanercept improves aging-induced cognitive deficits by reducing inflammation and vascular dysfunction in rats.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32569601
 
 
|keywords=* Aging
* Etanercept
* Inflammation
* Learning
* Memory
* TNFα
* Vascular dementia
|full-text-url=https://sci-hub.do/10.1016/j.physbeh.2020.113019
}}
{{medline-entry
|title=Bacterial antigen translocation and age as BMI-independent contributing factors on systemic inflammation in NAFLD patients.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32559006
 
 
|keywords=* NAFLD
* aging
* bacterial translocation
* cytokines
* insulin resistance
|full-text-url=https://sci-hub.do/10.1111/liv.14571
}}
{{medline-entry
|title=Bone marrow mesenchymal stem cells improve thymus and spleen function of aging rats through affecting P21/PCNA and suppressing oxidative stress.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32561691
 
 
|keywords=* BMSCs
* P21/PCNA
* aging
* immune system
* oxidative stress
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7343510
}}
{{medline-entry
|title=Glycolic acid adjusted to pH 4 stimulates collagen production and epidermal renewal without affecting levels of proinflammatory [[TNF]]-alpha in human skin explants.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32583600
 
 
|keywords=* cosmetics
* glycolic acid
* keratolytic agents
* rejuvenation
* skin aging
|full-text-url=https://sci-hub.do/10.1111/jocd.13570
}}
{{medline-entry
|title=A20 of nucleus pulposus cells plays a self-protection role via the nuclear factor-kappa B pathway in the inflammatory microenvironment.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32566144
 
 
|keywords=* A20
* Nuclear factor-kappa B
* Nucleus pulposus
* Senescence
* Tumour necrosis factor alpha
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7284293
}}
{{medline-entry
|title=Age-associated decline in neural, endocrine, and immune responses in men and women: Involvement of intracellular signaling pathways.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32563124
 
|mesh-terms=* Adult
* Aging
* Estradiol
* Female
* Humans
* Hydrocortisone
* Immunity, Cellular
* Intracellular Fluid
* Male
* Middle Aged
* Signal Transduction
* Testosterone
* Young Adult
|keywords=* 17β-estradiol
* Cortisol
* Cytokines
* Testosterone
* Tyrosine hydroxylase
|full-text-url=https://sci-hub.do/10.1016/j.jneuroim.2020.577290
}}
{{medline-entry
|title=Classical and lectin complement pathways and markers of inflammation for investigation of susceptibility to infections among healthy older adults.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32536956
 
 
|keywords=* Aging
* Complement system
* Elderly
* Immune
* Inflammation
* Lectin
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7285792
}}
{{medline-entry
|title=Activation of FoxO1/SIRT1/RANKL/OPG pathway may underlie the therapeutic effects of resveratrol on aging-dependent male osteoporosis.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32532246
 
 
|keywords=* Aging
* FoxO1
* Male osteoporosois
* OPG
* RANKL
* Resveratrol
* SIRT1
* Type II osteoporosis
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7293127
}}
{{medline-entry
|title=The senescence-associated secretome as an indicator of age and medical risk.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32554926
 
 
|keywords=* Aging
* Cellular senescence
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7406245
}}
{{medline-entry
|title=Exercise Partially Rejuvenates Muscle Stem Cells.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32484032
 
 
|keywords=* TGF-beta
* aging
* cyclin D1
* longevity
* regeneration
* stem cells
|full-text-url=https://sci-hub.do/10.1089/rej.2020.2359
}}
{{medline-entry
|title=Brazilian berry extract (Myrciaria jaboticaba): A promising therapy to minimize prostatic inflammation and oxidative stress.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32460430
 
|mesh-terms=* Age Factors
* Animals
* Anti-Inflammatory Agents
* Antioxidants
* Cyclooxygenase 2
* Diet, High-Fat
* Dose-Response Relationship, Drug
* Fruit
* Interleukin-1beta
* Interleukin-6
* Lipid Peroxidation
* Male
* Mice
* Myrtaceae
* Oxidative Stress
* Plant Extracts
* Prostatitis
* T-Lymphocytes
|keywords=* aging
* bioactive compounds
* obesity
* overweight
* polyphenols
|full-text-url=https://sci-hub.do/10.1002/pros.24017
}}
{{medline-entry
|title=Potential therapeutic effects of endothelial cells trans-differentiated from Wharton's Jelly-derived mesenchymal stem cells on altered vascular functions in aged diabetic rat model.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32426041
 
 
|keywords=* Aging
* Diabetes mellitus
* Endothelial cells
* Hypertension
* Mesenchymal stem cells
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7216374
}}
{{medline-entry
|title=[Effect of fragmented sleep on postoperative cognitive function and central neuroinflammation].
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32375444
 
|mesh-terms=* Aging
* Animals
* Cognition
* Cognition Disorders
* Fear
* Hippocampus
* Mice
* Mice, Inbred ICR
|keywords=* Central nervous system
* Cognition disorders
* Inflammation
* Postoperative period
* Sleep deprivation
|full-text-url=https://sci-hub.do/10.3760/cma.j.cn112137-20191215-02734
}}
{{medline-entry
|title=Can blocking inflammation enhance immunity during aging?
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32386656
 
 
|keywords=* Inflammaging
* p38-MAP Kinase
* senescence
* senolytics
|full-text-url=https://sci-hub.do/10.1016/j.jaci.2020.03.016
}}
{{medline-entry
|title=[FAS- and [[TNF]]-dependent ways participation in apoptosis mechanisms in hypotalumus in physiological and pathological aging.]
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32362081
 
|mesh-terms=* Aging
* Animals
* Apoptosis
* Female
* Hypothalamus
* Mice
* Mice, Transgenic
* Signal Transduction
* Tumor Necrosis Factor-alpha
* fas Receptor
|keywords=* FAS-, TNF-dependent pathways
* aging
* apoptosis
* hypothalamus
* neurons
 
}}
{{medline-entry
|title=Ultrasound-guided continuous thoracic paravertebral block alleviates postoperative delirium in elderly patients undergoing esophagectomy: A randomized controlled trial.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32332664
 
|mesh-terms=* Aged
* Aged, 80 and over
* Analgesia, Patient-Controlled
* Delirium
* Esophagectomy
* Female
* Geriatrics
* Humans
* Male
* Middle Aged
* Nerve Block
* Postoperative Complications
* Prospective Studies
* Ultrasonography
 
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7440095
}}
{{medline-entry
|title=17β-Estradiol improves insulin signalling and insulin resistance in the aged female hearts: Role of inflammatory and anti-inflammatory cytokines.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32311377
 
|mesh-terms=* Aging
* Animals
* Anti-Inflammatory Agents
* Blood Glucose
* Cytokines
* Estradiol
* Female
* Heart
* Insulin
* Insulin Resistance
* Lipid Metabolism
* Menopause
* Ovariectomy
* Rats
* Rats, Wistar
* Signal Transduction
|keywords=* 17β-estradiol
* Aging
* Cytokines
* Heart
* Insulin signalling
|full-text-url=https://sci-hub.do/10.1016/j.lfs.2020.117673
}}
{{medline-entry
|title=Synergistic Antitumor Efficacy of Magnetohyperthermia and Poly(lactic-co-glycolic acid)-Encapsulated Selol in Ehrlich Breast Adenocarcinoma Treatment in Elderly Swiss Mice.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32252879
 
|mesh-terms=* Adenocarcinoma
* Aging
* Animals
* Cell Line, Tumor
* Glycols
* Humans
* Mice
* Nanoparticles
* Polylactic Acid-Polyglycolic Acid Copolymer
* Selenium Compounds
 
|full-text-url=https://sci-hub.do/10.1166/jbn.2020.2890
}}
{{medline-entry
|title=Pinitol suppresses [[TNF]]-α-induced chondrocyte senescence.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32200264
 
 
|keywords=* Cellular senescence
* Nrf2
* Osteoarthritis
* Pinitol
* TNF-α
|full-text-url=https://sci-hub.do/10.1016/j.cyto.2020.155047
}}
{{medline-entry
|title=[Aging of skin fibroblasts: genetic and epigenetic factors.]
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32160428
 
|mesh-terms=* Cells, Cultured
* Epigenesis, Genetic
* Fibroblasts
* Humans
* Skin Aging
|keywords=* aging
* melatonin
* signal molecules
* skin fibroblasts
 
}}
{{medline-entry
|title=Functional and traditional training improve muscle power and reduce proinflammatory cytokines in older women: A randomized controlled trial.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32151735
 
 
|keywords=* Aging
* Cytokines.
* Dynapenia
* Inflamm-aging
|full-text-url=https://sci-hub.do/10.1016/j.exger.2020.110920
}}
{{medline-entry
|title=Associations of [[TNF]]-α -308 G>A and [[TNF]]-β 252 A>G with Physical Function and BNP-Rugao Longevity and Ageing Study.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32115620
 
|mesh-terms=* Aged
* Aged, 80 and over
* Aging
* Female
* Humans
* Longevity
* Male
* Natriuretic Peptide, Brain
* Tumor Necrosis Factor-alpha
|keywords=* Physical function
* TNF-α -308 G>A polymorphism
* TNF-β 252 A>G polymorphism
* plasma BNP
* population study.
|full-text-url=https://sci-hub.do/10.1007/s12603-020-1336-1
}}
{{medline-entry
|title=3D TECA hydrogel reduces cellular senescence and enhances fibroblasts migration in wound healing.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32104405
 
 
|keywords=* 3D TECA
* Cellular senescence
* Fibroblast migration
* SA-β-gal
* TNF-α
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7032142
}}
{{medline-entry
|title=Regulatory Effect of Anwulignan on the Immune Function Through Its Antioxidation and Anti-Apoptosis in D-Galactose-Induced Aging Mice.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32099340
 
|mesh-terms=* Animals
* Antioxidants
* Apoptosis
* Cytokines
* Immunologic Factors
* Immunosenescence
* Male
* Medicine, Chinese Traditional
* Mice
* Models, Animal
* NF-E2-Related Factor 2
* Oxidative Stress
* Phytochemicals
* Schisandra
* Spleen
|keywords=* Anwulignan
* anti-apoptosis
* antioxidation
* immunosenescence
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6996228
}}
{{medline-entry
|title=Pretreatment Frailty Is Independently Associated With Increased Risk of Infections After Immunosuppression in Patients With Inflammatory Bowel Diseases.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32105728
 
 
|keywords=* Aging
* Immunosuppression
* Side Effect
* Thiopurine
|full-text-url=https://sci-hub.do/10.1053/j.gastro.2020.02.032
}}
{{medline-entry
|title=The Citrus Flavonoid Naringenin Protects the Myocardium from Ageing-Dependent Dysfunction: Potential Role of SIRT1.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32047577
 
|mesh-terms=* Aging
* Animals
* Antioxidants
* Cell Line
* Cellular Senescence
* Citrus
* Cytoprotection
* Disease Models, Animal
* Flavanones
* Humans
* Interleukin-6
* Mice
* Myocardium
* Protein Binding
* Rats
* Reactive Oxygen Species
* Sirtuin 1
* Tumor Necrosis Factor-alpha
 
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7003265
}}
{{medline-entry
|title=In the Absence of a TCR Signal IL-2/IL-12/18-Stimulated γδ T Cells Demonstrate Potent Anti-Tumoral Function Through Direct Killing and Senescence Induction in Cancer Cells.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31947966
 
 
|keywords=* IL-12
* IL-18
* TCR bypass stimulation
* senescence
* γδ T cells
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7017313
}}
{{medline-entry
|title=Aging is associated with loss of beneficial effects of estrogen on leptin responsiveness in mice fed high fat diet: Role of estrogen receptor α and cytokines.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31904410
 
 
|keywords=* Aging
* Cytokines
* ERα
* Estrogen
* Leptin sensitivity
|full-text-url=https://sci-hub.do/10.1016/j.mad.2019.111198
}}
{{medline-entry
|title=Mitochondrial Dysfunction and Alpha-Lipoic Acid: Beneficial or Harmful in Alzheimer's Disease?
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31885820
 
|mesh-terms=* Aging
* Alzheimer Disease
* Amyloid beta-Peptides
* Animals
* Cytokines
* Humans
* Inflammation Mediators
* Mitochondria
* Neurofibrillary Tangles
* Neurons
* Neuroprotective Agents
* Thioctic Acid
 
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6914903
}}
{{medline-entry
|title=Design, synthesis and evaluation of diosgenin carbamate derivatives as multitarget anti-Alzheimer's disease agents.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31837501
 
|mesh-terms=* Aging
* Alzheimer Disease
* Amyloid beta-Peptides
* Animals
* Anti-Inflammatory Agents, Non-Steroidal
* Astrocytes
* Carbamates
* Cell Line, Tumor
* Cell Survival
* Diosgenin
* Dose-Response Relationship, Drug
* Drug Design
* Galactose
* Humans
* Inflammation
* Male
* Mice
* Mice, Inbred ICR
* Molecular Structure
* Neuroprotective Agents
* Oxidative Stress
* Protein Aggregates
* Structure-Activity Relationship
|keywords=* Alzheimer’s disease
* Anti-Aβ activity
* Anti-inflammatory
* Antioxidant
* Diosgenin
* Multi-target-directed ligands
|full-text-url=https://sci-hub.do/10.1016/j.ejmech.2019.111913
}}
{{medline-entry
|title=Oral Administration of Okara Soybean By-Product Attenuates Cognitive Impairment in a Mouse Model of Accelerated Aging.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31816987
 
|mesh-terms=* Aging
* Animal Feed
* Animals
* Brain-Derived Neurotrophic Factor
* Cognitive Dysfunction
* Diet
* Gastrointestinal Microbiome
* Gene Expression Regulation
* Hippocampus
* Male
* Mice
* Soybeans
* Tumor Necrosis Factor-alpha
|keywords=* BDNF
* SAMP8
* cognitive impairment
* neuroprotection
* okara
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6950093
}}
{{medline-entry
|title=Electric vagal nerve stimulation inhibits inflammation and improves early postoperation cognitive dysfunction in aged rats.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31759387
 
|mesh-terms=* Aging
* Anesthesia, General
* Animals
* Behavior, Animal
* Hippocampus
* Inflammation
* Male
* Maze Learning
* NF-kappa B
* Postoperative Cognitive Complications
* Rats
* Rats, Sprague-Dawley
* Splenectomy
* Tumor Necrosis Factor-alpha
* Vagus Nerve Stimulation
|keywords=* Cognitive dysfunction
* General anesthesia
* Inflammation
* Vagus nerve stimulation
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6875068
}}
{{medline-entry
|title=Metformin decreases LPS-induced inflammatory response in rabbit annulus fibrosus stem/progenitor cells by blocking HMGB1 release.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31772144
 
|mesh-terms=* Animals
* Annulus Fibrosus
* Anti-Inflammatory Agents
* Cellular Senescence
* HMGB1 Protein
* Inflammation
* Intervertebral Disc Degeneration
* Lipopolysaccharides
* Metformin
* Rabbits
* Stem Cells
|keywords=* HMGB1
* annulus fibrosis stem cells
* cell senescence
* intervertebral disc degeneration
* metformin
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6914423
}}
{{medline-entry
|title=The effects of blueberry and strawberry serum metabolites on age-related oxidative and inflammatory signaling in vitro.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31746877
 
|mesh-terms=* Aged
* Aging
* Animals
* Blueberry Plants
* Double-Blind Method
* Female
* Fragaria
* Fruit
* Humans
* Male
* Microglia
* Middle Aged
* Nitric Oxide
* Nitric Oxide Synthase Type II
* Oxidative Stress
* Postprandial Period
* Rats
* Tumor Necrosis Factor-alpha
 
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6906224
}}
{{medline-entry
|title=Arsenic induces human chondrocyte senescence and accelerates rat articular cartilage aging.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31734849
 
 
|keywords=* Aging
* Arsenic
* Articular cartilage
* Human chondrocyte
* Senescence
* Senescence-associated secretory phenotype
|full-text-url=https://sci-hub.do/10.1007/s00204-019-02607-2
}}
{{medline-entry
|title=Bone Benefits of Fish Oil Supplementation Depend on its EPA and DHA Content.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31717258
 
|mesh-terms=* Age Factors
* Animals
* Bone Density
* Bone Density Conservation Agents
* Bone Marrow Cells
* Bone Remodeling
* Bone and Bones
* Cells, Cultured
* Cytokines
* Dietary Supplements
* Disease Models, Animal
* Docosahexaenoic Acids
* Eicosapentaenoic Acid
* Female
* JNK Mitogen-Activated Protein Kinases
* Mice, Inbred C57BL
* Osteoporosis
* Signal Transduction
* p38 Mitogen-Activated Protein Kinases
|keywords=* aging
* bone mineral density
* bone resorption
* concentrated fish oil
* cytokines
* inflammation
* omega-3 fatty acids
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6893665
}}
{{medline-entry
|title=Inflammaging phenotype in rhesus macaques is associated with a decline in epithelial barrier-protective functions and increased pro-inflammatory function in CD161-expressing cells.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31713098
 
|mesh-terms=* Aging
* Animals
* Chronic Disease
* Cytokines
* Disease Models, Animal
* Epithelium
* Flow Cytometry
* Immunity, Innate
* Inflammation
* Macaca mulatta
* NK Cell Lectin-Like Receptor Subfamily B
* Phenotype
* Th17 Cells
|keywords=* CD161+ cells
* I-FABP
* Inflammaging
* LBP
* Leaky gut
* sCD14
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6925095
}}
{{medline-entry
|title=Single-cell transcriptomics reveals expansion of cytotoxic CD4 T cells in supercentenarians.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31719197
 
|mesh-terms=* Adult
* Aged
* Aged, 80 and over
* B-Lymphocytes
* CD4-Positive T-Lymphocytes
* Case-Control Studies
* Cell Differentiation
* Cells, Cultured
* Clonal Evolution
* Gene Expression Profiling
* Humans
* Interferon-gamma
* Leukocytes, Mononuclear
* Middle Aged
* Single-Cell Analysis
* Tumor Necrosis Factor-alpha
|keywords=* CD4 CTL
* aging
* centenarian
* single-cell transcriptome
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6883788
}}
{{medline-entry
|title=Gut microbiota combined with metabolomics reveals the metabolic profile of the normal aging process and the anti-aging effect of FuFang Zhenshu TiaoZhi(FTZ) in mice.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31704617
 
|mesh-terms=* Aging
* Animals
* Bacteria
* Biomarkers
* Drugs, Chinese Herbal
* Gastrointestinal Microbiome
* Hyperlipidemias
* Lipid Metabolism
* Male
* Metabolome
* Metabolomics
* Mice
* Mice, Inbred C57BL
|keywords=* Aging
* FTZ
* Gut microbiota
* Metabolomics
|full-text-url=https://sci-hub.do/10.1016/j.biopha.2019.109550
}}
{{medline-entry
|title=Intervertebral disc ageing and degeneration: The antiapoptotic effect of oestrogen.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31669486
 
|mesh-terms=* Aging
* Animals
* Apoptosis
* Cytokines
* Estrogens
* Female
* Humans
* Inflammation
* Intervertebral Disc
* Intervertebral Disc Degeneration
* Intervertebral Disc Displacement
* Male
* Phosphatidylinositol 3-Kinases
* Signal Transduction
|keywords=* Ageing
* Apoptosis
* Intervertebral disc degeneration
* Oestrogen
* Spine
|full-text-url=https://sci-hub.do/10.1016/j.arr.2019.100978
}}
{{medline-entry
|title=MicroRNA 16-5p is upregulated in calorie-restricted mice and modulates inflammatory cytokines of macrophages.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31654705
 
|mesh-terms=* Aging
* Animals
* Caloric Restriction
* Cytokines
* Diet Therapy
* Inflammation
* Interleukin-1beta
* Macrophages
* Male
* Mice
* Mice, Inbred C57BL
* MicroRNAs
* Models, Animal
* RAW 264.7 Cells
* Transcriptional Activation
* Tumor Necrosis Factor-alpha
* Up-Regulation
|keywords=* Caloric restriction
* Cellular immunology
* Cytokines
* Macrophages
* microRNA
|full-text-url=https://sci-hub.do/10.1016/j.gene.2019.144191
}}
{{medline-entry
|title=Aerobic exercise modulates cytokine profile and sleep quality in elderly.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31656505
 
|mesh-terms=* Aged
* Cytokines
* Exercise
* Female
* Humans
* Male
* Middle Aged
* Sedentary Behavior
* Sleep Wake Disorders
|keywords=* Sleep quality
* aerobic exercise
* aging
* inflammatory cytokines
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6794533
}}
{{medline-entry
|title=Trehalose targets Nrf2 signal to alleviate d-galactose induced aging and improve behavioral ability.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31630800
 
|mesh-terms=* Aging
* Animals
* Disease Models, Animal
* Dose-Response Relationship, Drug
* Galactose
* Male
* Memory Disorders
* Mice
* Mice, Inbred ICR
* NF-E2-Related Factor 2
* Signal Transduction
* Trehalose
|keywords=* Antioxidant stress
* Cognitive impairment
* Inflammation
* Nrf2
* Trehalose
* d-galactose
|full-text-url=https://sci-hub.do/10.1016/j.bbrc.2019.10.088
}}
{{medline-entry
|title=Anti-Inflammatory and Anti-Aging Evaluation of Pigment-Protein Complex Extracted from [i]Chlorella Pyrenoidosa[/i].
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31623220
 
|mesh-terms=* Aging
* Animals
* Anti-Inflammatory Agents
* Antioxidants
* Biological Products
* Chlorella
* Cytokines
* Disease Models, Animal
* Galactose
* Inflammation
* Interleukin-6
* Lipopolysaccharides
* Macrophages
* Male
* Mice
* Mice, Inbred C57BL
* NF-kappa B
* Nitric Oxide
* Oxidative Stress
* RAW 264.7 Cells
* Superoxide Dismutase
* Tumor Necrosis Factor-alpha
|keywords=* Chlorella pyrenoidosa
* NF-κB
* PPARs
* anti-aging
* anti-inflammation
* pigment–protein complex
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6836285
}}
{{medline-entry
|title=Inflammatory mediators and the risk of falls among older women with acute low back pain: data from Back Complaints in the Elders (BACE)-Brazil.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31606818
 
 
|keywords=* Aging
* BACE
* Cytokines
* Disability
* Fall risk
* Low back pain
|full-text-url=https://sci-hub.do/10.1007/s00586-019-06168-x
}}
{{medline-entry
|title=Acetylcholinesterase inhibitors targeting the cholinergic anti-inflammatory pathway: a new therapeutic perspective in aging-related disorders.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31583530
 
 
|keywords=* Acetylcholinesterase inhibitor
* Aging
* CHRFAM7A
* CHRNA7
* Cholinergic anti-inflammatory pathway
* Neuroinflammation
|full-text-url=https://sci-hub.do/10.1007/s40520-019-01359-4
}}
{{medline-entry
|title=Study on Metabolic Trajectory of Liver Aging and the Effect of Fufang Zhenzhu Tiaozhi on Aging Mice.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31555127
 
 
|keywords=* Fufang Zhenzhu Tiaozhi
* liver aging
* mass spectrometry
* metabolomics
* ultra-performance liquid chromatography
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6722462
}}
{{medline-entry
|title=Systemic Tumor Necrosis Factor-Alpha Trajectories Relate to Brain Health in Typically Aging Older Adults.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31549145
 
 
|keywords=* Brain aging
* Cognition
* Gray matter volume
* Inflammation
* Neuroimaging
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7457183
}}
{{medline-entry
|title=Targeting senescence improves angiogenic potential of adipose-derived mesenchymal stem cells in patients with preeclampsia.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31521202
 
|mesh-terms=* Adipose Tissue
* Adult
* Cell Movement
* Cell Proliferation
* Cell Survival
* Cellular Senescence
* Dasatinib
* Female
* Humans
* Mesenchymal Stem Cells
* Pre-Eclampsia
* Pregnancy
* Protein Kinase Inhibitors
|keywords=* Angiogenesis, Senolytics, Dasatinib
* Mesenchymal stem cells
* Preeclampsia
* Senescence
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6744626
}}
{{medline-entry
|title=Suppression of gut dysbiosis by Bifidobacterium longum alleviates cognitive decline in 5XFAD transgenic and aged mice.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31413350
 
|mesh-terms=* Aging
* Animals
* Bifidobacterium longum
* Cognitive Dysfunction
* Dysbiosis
* Feces
* Gastrointestinal Microbiome
* Humans
* Lipopolysaccharides
* Mice
* Mice, Transgenic
* Probiotics
 
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6694197
}}
{{medline-entry
|title=Moderate hyperoxia induces senescence in developing human lung fibroblasts.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31411059
 
|mesh-terms=* Autophagy
* CCAAT-Enhancer-Binding Protein-beta
* Cell Proliferation
* Cellular Senescence
* Cyclin-Dependent Kinase Inhibitor p21
* DNA Damage
* Endoplasmic Reticulum Stress
* Etoposide
* Extracellular Matrix
* Fetus
* Fibroblasts
* G2 Phase Cell Cycle Checkpoints
* Gene Expression Regulation
* Humans
* Hyperoxia
* Interleukin-1
* Interleukin-8
* Lung
* Matrix Metalloproteinase 3
* Oxygen
* Plasminogen Activator Inhibitor 1
* Primary Cell Culture
* Tumor Necrosis Factor-alpha
* Tumor Suppressor Protein p53
|keywords=* autophagy
* endoplasmic reticulum stress
* lung development
* oxygen
* senescence
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6879905
}}
{{medline-entry
|title=Aging-related carcinoembryonic antigen-related cell adhesion molecule 1 signaling promotes vascular dysfunction.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31389127
 
|mesh-terms=* Aged
* Aging
* Animals
* Antigens, CD
* Cell Adhesion Molecules
* Cells, Cultured
* Endothelium, Vascular
* Humans
* Mice
* Mice, Inbred C57BL
* Mice, Knockout
* Middle Aged
* Signal Transduction
|keywords=* aging
* anti-aging
* cytokines
* inflammation
* mouse
* reactive oxygen species
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6826129
}}
{{medline-entry
|title=Microglia Express Insulin-Like Growth Factor-1 in the Hippocampus of Aged APP /PS1  Transgenic Mice.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31417357
 
 
|keywords=* aging
* cerebral amyloidosis
* insulin-like growth factor
* neurogenesis
* neuroinflammation
* tumor necrosis factor
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6682662
}}
{{medline-entry
|title=Age- and diet-specific effects of chronic exposure to chlorpyrifos on hormones, inflammation and gut microbiota in rats.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31400786
 
|mesh-terms=* Aging
* Animals
* Chlorpyrifos
* Diet, High-Fat
* Gastrointestinal Microbiome
* Hypothalamo-Hypophyseal System
* Inflammation
* Male
* Pituitary-Adrenal System
* RNA, Ribosomal, 16S
* Rats
|keywords=* 16S rRNA gene sequencing
* Gut endocrine
* Gut-brain axis
* Hormone
* Hypothalamic-pituitary-adrenal axis
* Inflammation
|full-text-url=https://sci-hub.do/10.1016/j.pestbp.2019.05.018
}}
==TOMM20==
 
{{medline-entry
|title=Effect of aging on mitochondria and metabolism of bovine granulosa cells.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32921645
 
 
|keywords=* Aging
* Cow
* Granulosa cells
* Mitochondria
|full-text-url=https://sci-hub.do/10.1262/jrd.2020-071
}}
==TP53==
 
{{medline-entry
|title=p53 inhibits the osteogenic differentiation but does not induce senescence in human dental follicle cells.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32473528
 
 
|keywords=* Cellular senescence
* Dental follicle cells
* E2F-1
* Osteogenic differentiation
* p53
|full-text-url=https://sci-hub.do/10.1016/j.diff.2020.05.003
}}
{{medline-entry
|title=Mutational spectrum and dynamics of clonal hematopoiesis in anemia of older individuals.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32243522
 
|mesh-terms=* Age Factors
* Aged
* Aging
* Anemia
* Female
* Hematopoiesis
* Humans
* Kaplan-Meier Estimate
* Male
* Middle Aged
* Mutation
* Prospective Studies
 
|full-text-url=https://sci-hub.do/10.1182/blood.2019004362
}}
{{medline-entry
|title=[[TP53]]/miR-34a-associated signaling targets [i]SERPINE1[/i] expression in human pancreatic cancer.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31986125
 
 
|keywords=* Aging
* PDAC
* SERPINE1
* TP53
* cancer
* miR-34a
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7041729
}}
{{medline-entry
|title=Expression of p16 in nodular fasciitis: an implication for self-limited and inflammatory nature of the lesion.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31933915
 
 
|keywords=* CDK4
* MDM2
* TP53
* nodular fasciitis
* p16
* senescence
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6945175
}}
==TPH1==
 
{{medline-entry
|title=[i]Lactobacillus plantarum[/i] DR7 improved brain health in aging rats via the serotonin, inflammatory and apoptosis pathways.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/33245015
 
 
|keywords=* Lactobacillus spp.
* aging
* brain
|full-text-url=https://sci-hub.do/10.3920/BM2019.0200
}}
==TPO==
 
{{medline-entry
|title=Megakaryocytes promote osteoclastogenesis in aging.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32634116
 
 
|keywords=* aging
* bone marrow macrophage
* megakaryocyte
* osteoclast
* thrombopoietin
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7425434
}}
==TPP1==
 
{{medline-entry
|title=FBW7 Mediates Senescence and Pulmonary Fibrosis through Telomere Uncapping.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/33086033
 
 
|keywords=* DNA damage response
* FBXW7
* TPP1
* cellular senescence
* chronic stress
* idiopathic pulmonary fibrosis
* premature aging
* proteostasis
* stem cells
* telomere
* telomere uncapping
|full-text-url=https://sci-hub.do/10.1016/j.cmet.2020.10.004
}}
==TPR==
 
{{medline-entry
|title=Catalytic Performances of Cu/MCM-22 Zeolites with Different Cu Loadings in NH -SCR.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/33143192
 
 
|keywords=* Cu loading
* Cu/MCM-22
* NH3-SCR
* hydrothermal aging
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7694057
}}
{{medline-entry
|title=Do traits of plant species predict the efficacy of species distribution models for finding new occurrences?
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32551077
 
 
|keywords=* dispersal
* generalist
* lifespan
* niche models
* range size
* specialist
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7297770
}}
{{medline-entry
|title=In-situ modified the surface of Pt-doped perovskite catalyst for soot oxidation.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31541957
 
 
|keywords=* Aging resistance
* Amorphization
* Surface modification
* Symmetrical structure
|full-text-url=https://sci-hub.do/10.1016/j.jhazmat.2019.121210
}}
==TRAF3==
 
{{medline-entry
|title=[[TRAF3]], a Target of MicroRNA-363-3p, Suppresses Senescence and Regulates the Balance Between Osteoblastic and Adipocytic Differentiation of Rat Bone Marrow-Derived Mesenchymal Stem Cells.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32111144
 
 
|keywords=* TRAF3
* adipogenic differentiation
* bone marrow-derived mesenchymal stem cells
* miR-363-3p
* osteogenic differentiation
* senescence
|full-text-url=https://sci-hub.do/10.1089/scd.2019.0276
}}
==TREM2==
 
{{medline-entry
|title=Loss of [[TREM2]] Confers Resilience to Synaptic and Cognitive Impairment in Aged Mice.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/33139402
 
 
|keywords=* TREM2
* aging
* dendritic spine density
* learning and memory
* long-term potentiation
* synaptic plasticity
|full-text-url=https://sci-hub.do/10.1523/JNEUROSCI.2193-20.2020
}}
{{medline-entry
|title=Triggering Receptor Expressed on Myeloid Cell 2 R47H Exacerbates Immune Response in Alzheimer's Disease Brain.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/33101276
 
 
|keywords=* NKG2D ligands
* aging
* inflammation
* interferon type I response
* microglia
* neurodegeneration
* senescence
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7546799
}}
{{medline-entry
|title=Knockdown of astrocytic [[TREM2]] in the hippocampus relieves cognitive decline in elderly male mice.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32991925
 
 
|keywords=* Aging
* Long-term potentiation
* TREM2
* astrocytes
* learning and memory
|full-text-url=https://sci-hub.do/10.1016/j.bbr.2020.112939
}}
==TRIM21==
 
{{medline-entry
|title=[[TRIM21]] overexpression promotes tumor progression by regulating cell proliferation, cell migration and cell senescence in human glioma.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32064156
 
 
|keywords=* Glioma
* TRIM21
* cell senescence
* drug resistance
* p53-p21 pathway
* prognosis
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7017742
}}
==TRIM27==
 
{{medline-entry
|title=[[TRIM27]] Functions as a Novel Oncogene in Non-Triple-Negative Breast Cancer by Blocking Cellular Senescence through p21 Ubiquitination.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/33251042
 
 
|keywords=* EP300
* TRIM27
* breast cancer
* cell apoptosis
* cell senescence
* chemoresistance
* p21
* prognosis
* transcription
* ubiquitination
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7666371
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7666371
}}
==TRIP13==
{{medline-entry
|title=BubR1 allelic effects drive phenotypic heterogeneity in mosaic-variegated aneuploidy progeria syndrome.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31738183
|mesh-terms=* Aging
* Alleles
* Animals
* Cell Cycle Proteins
* Chromosome Disorders
* Lung Neoplasms
* Mice
* Mice, Inbred C57BL
* Mitosis
* Mosaicism
* Mutation
* Phenotype
* Progeria
* Protein-Serine-Threonine Kinases
|keywords=* Aging
* Cancer
* Cellular senescence
* Genetic diseases
* Oncology
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6934189
}}
==TRPC6==
{{medline-entry
|title=Redox and mTOR-dependent regulation of plasma lamellar calcium influx controls the senescence-associated secretory phenotype.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32686475
|keywords=* SASP
* Senescence
* TRPC6
* calcium
* hydrogen peroxide
* mTOR
|full-text-url=https://sci-hub.do/10.1177/1535370220943122
}}
==TRPC7==
{{medline-entry
|title=Nociceptive transient receptor potential canonical 7 ([[TRPC7]]) mediates aging-associated tumorigenesis induced by ultraviolet B.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31755176
|keywords=* TRPC7
* aging
* p53
* tumor initiator gene
* tumorigenesis
* ultraviolet pathology
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6974716
}}
==TRPV4==
{{medline-entry
|title=[[TRPV4]] receptor as a functional sensory molecule in bladder urothelium: Stretch-independent, tissue-specific actions and pathological implications.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31914645
|mesh-terms=* Animals
* Calcium
* Guinea Pigs
* Humans
* Muscle Contraction
* Muscle, Smooth
* TRPV Cation Channels
* Urinary Bladder
* Urothelium
|keywords=* ATP release
* TRPV4 receptor
* aging
* overactive bladders
* urothelium
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6973053
}}
{{medline-entry
|title=Exercise restores impaired endothelium-derived hyperpolarizing factor-mediated vasodilation in aged rat aortic arteries via the [[TRPV4]]-K 2.3 signaling complex.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31564840
|mesh-terms=* Animals
* Biological Factors
* Cardiovascular Diseases
* Endothelial Cells
* Endothelium, Vascular
* Male
* Potassium Channels, Calcium-Activated
* Rats
* Rats, Sprague-Dawley
* TRPV Cation Channels
* Vasodilation
|keywords=* EDHF
* KCa2.3
* TRPV4
* aging
* endothelium
* exercise
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6731547
}}
==TSPO==
{{medline-entry
|title=Age and Sex Influence the Neuro-inflammatory Response to a Peripheral Acute LPS Challenge.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31749696
|keywords=* 18 kDa translocator protein
* aging
* astrocytes
* microglia
* neuroinflammation
* triggering receptor expressed on myeloid cells 2
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6848890
}}
{{medline-entry
|title=Upregulation of cannabinoid receptor type 2, but not [[TSPO]], in senescence-accelerated neuroinflammation in mice: a positron emission tomography study.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31707986
|mesh-terms=* Aging
* Animals
* Brain
* Inflammation
* Mice
* Microglia
* Positron-Emission Tomography
* Radiopharmaceuticals
* Receptor, Cannabinoid, CB2
* Receptors, GABA
* Up-Regulation
|keywords=* Cannabinoid receptor type 2
* Immunostaining
* Microglial activation
* Positron emission tomography
* Senescence-accelerated prone mouse
* Translocator protein
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6842455
}}
==TST==
{{medline-entry
|title=H S Donors Reverse Age-Related Gastric Malfunction Impaired Due to Fructose-Induced Injury [i]via[/i] CBS, CSE, and [[TST]] Expression.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32848752
|keywords=* aging
* donor
* fructose
* gastric mucosa
* hydrogen sulfide
* oxidative stress
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7396573
}}
{{medline-entry
|title=Adaptations in mechanical muscle function, muscle morphology, and aerobic power to high-intensity endurance training combined with either traditional or power strength training in older adults: a randomized clinical trial.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32239311
|keywords=* Aging
* Concurrent training
* Explosive force
* Functional capacity
* HIIT
|full-text-url=https://sci-hub.do/10.1007/s00421-020-04355-z
}}
{{medline-entry
|title=Digital phenotyping by consumer wearables identifies sleep-associated markers of cardiovascular disease risk and biological aging.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31602410
|mesh-terms=* Adult
* Aged
* Aging
* Body Mass Index
* Cardiovascular Diseases
* Cohort Studies
* Female
* Humans
* Male
* Middle Aged
* Risk Factors
* Self Report
* Sleep
* Telomere
* Waist Circumference
* Wearable Electronic Devices
* Young Adult
|keywords=* Data integration
* Predictive markers
* Risk factors
* Senescence
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6778117
}}
{{medline-entry
|title=Objective Sleep Duration in Older Adults: Results From The Irish Longitudinal Study on Ageing.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31579942
|mesh-terms=* Accelerometry
* Aged
* Aging
* Cross-Sectional Studies
* Exercise
* Female
* Health Status
* Humans
* Independent Living
* Ireland
* Longitudinal Studies
* Male
* Polysomnography
* Self Report
* Sleep
* Time Factors
|keywords=* GENEActiv
* accelerometer
* actigraphy
* older population
* sleep duration
|full-text-url=https://sci-hub.do/10.1111/jgs.16177
}}
==TTL==
{{medline-entry
|title=Longitudinal Associations of Body Mass Index, Waist Circumference, and Waist-to-Hip Ratio with Biomarkers of Oxidative Stress in Older Adults: Results of a Large Cohort Study.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31986512
|mesh-terms=* Aged
* Aged, 80 and over
* Aging
* Biomarkers
* Body Mass Index
* Cohort Studies
* Female
* Germany
* Humans
* Longitudinal Studies
* Male
* Middle Aged
* Oxidative Stress
* Waist Circumference
* Waist-Hip Ratio
|keywords=* Body mass index
* Free radicals
* Oxidative stress
* Reactive oxygen metabolites
* Total thiol levels
* Waist circumference
* Waist-to-hip ratio
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7098284
}}
==TTN==
{{medline-entry
|title=LncRNA [[TTN]]-AS1 regulates osteosarcoma cell apoptosis and drug resistance via the miR-134-5p/MBTD1 axis.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31600142
|mesh-terms=* Aging
* Apoptosis
* Brain Neoplasms
* Cell Line, Tumor
* Cell Proliferation
* Chromosomal Proteins, Non-Histone
* Computational Biology
* Drug Resistance
* Gene Expression Regulation, Neoplastic
* Humans
* MicroRNAs
* Osteosarcoma
* RNA, Long Noncoding
|keywords=* aging and age-related diseases
* lncRNA TTN-AS1
* malignant brain tumour domain containing protein 1
* miR-134-5p
* osteosarcoma
* resistance
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6814585
}}
==TTR==
{{medline-entry
|title=Cellular secretion and cytotoxicity of transthyretin mutant proteins underlie late-onset amyloidosis and neurodegeneration.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31728576
|mesh-terms=* Amyloid Neuropathies, Familial
* Animals
* Cell Death
* Cell Line, Tumor
* Disease Models, Animal
* Drosophila
* HEK293 Cells
* Humans
* Locomotion
* Longevity
* Mutant Proteins
* Mutation
* Nerve Degeneration
* Prealbumin
|keywords=* Amyloidosis
* Drosophila melanogaster
* ERQC
* Endoplasmic reticulum quality control
* Proteostasis
* TTR
* Transthyretin
|full-text-url=https://sci-hub.do/10.1007/s00018-019-03357-1
}}
==TXNIP==
{{medline-entry
|title=Panax notoginseng saponins attenuate neuroinflammation through [[TXNIP]]-mediated NLRP3 inflammasome activation in aging rats.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/33176641
|keywords=* Aging
* Microglia
* NLRP3 inflammasome
* Saponins from Panax notoginseng.
* TXNIP
* neuroinflammation
|full-text-url=https://sci-hub.do/10.2174/1389201021999201110204735
}}
{{medline-entry
|title=Redox homeostasis and cell cycle activation mediate beta-cell mass expansion in aged, diabetes-prone mice under metabolic stress conditions: Role of thioredoxin-interacting protein ([[TXNIP]]).
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/33128997
|keywords=* Aging
* Beta-cells
* Cell cycle
* Metabolic stress
* Redox homeostasis
* Thioredoxin-interacting protein
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7589534
}}
{{medline-entry
|title=[Effect of diabetic induced thioredoxin interacting protein ([[TXNIP]]) on islet cell senescence].
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32744003
|mesh-terms=* Animals
* Carrier Proteins
* Cellular Senescence
* Diabetes Mellitus, Experimental
* Islets of Langerhans
* Mice
* Thioredoxins
|keywords=* INS-1 cell
* cell senescence
* diabetes
* thioredoxin interacting protein
|full-text-url=https://sci-hub.do/10.12047/j.cjap.5878.2020.027
}}
{{medline-entry
|title=PRMT5-TRIM21 interaction regulates the senescence of osteosarcoma cells by targeting the [[TXNIP]]/p21 axis.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32023548
|keywords=* PRMT5
* TRIM21
* TXNIP
* p21
* senescence
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7041745
}}
==TXNRD2==
{{medline-entry
|title=Wogonin induces cellular senescence in breast cancer via suppressing [[TXNRD2]] expression.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32671444
|keywords=* Breast cancer
* Immune surveillance
* ROS
* Senescence
* TXNRD2
* Wogonin
|full-text-url=https://sci-hub.do/10.1007/s00204-020-02842-y
}}
==U2AF1==
{{medline-entry
|title=Isobaric tags for relative and absolute quantitation (iTRAQ)-based proteomic analysis of mRNA splicing relevant proteins in aging HSPCs.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32141009
|keywords=* Aging
* DEPs
* HSPC
* iTRAQ
* mRNA splicing
|full-text-url=https://sci-hub.do/10.1007/s40520-020-01509-z
}}
==UACA==
{{medline-entry
|title=Knockdown of [i][[UACA]][/i] inhibitsproliferation and invasion and promotes senescence of hepatocellular carcinoma cells.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31949867
|keywords=* HIF1α
* UACA
* hepatocellular carcinoma
* invasion
* knockdown
* proliferation
* senescence
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6962967
}}
==UCHL1==
{{medline-entry
|title=Abolishing [[UCHL1]]'s hydrolase activity exacerbates TBI-induced axonal injury and neuronal death in mice.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/33159930
|keywords=* Aging
* Axonal injury
* Neurodegeneration
* Traumatic brain injury
* Ubiquitin carboxy terminal hydrolase L1
* Ubiquitin proteasome pathway
|full-text-url=https://sci-hub.do/10.1016/j.expneurol.2020.113524
}}
==UCP1==
{{medline-entry
|title=Muscle-dependent regulation of adipose tissue function in long-lived growth hormone-mutant mice.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32464603
|keywords=* adipose tissue
* aging
* growth hormone
* inflammation
* uncoupling protein 1 (UCP1)
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7288969
}}
{{medline-entry
|title=Lack of [[UCP1]] stimulates fatty liver but mediates [[UCP1]]-independent action of beige fat to improve hyperlipidemia in Apoe knockout mice.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32179129
|keywords=* Apoe knockout mice
* Beige fat
* Gene expression
* Hyperlipidemia
* Longevity
* Uncoupling protein 1
|full-text-url=https://sci-hub.do/10.1016/j.bbadis.2020.165762
}}
{{medline-entry
|title=Postnatal leptin surge is critical for the transient induction of the developmental beige adipocytes in mice.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31961706
|mesh-terms=* Adipocytes, Beige
* Adipocytes, White
* Adipose Tissue
* Aging
* Animals
* Dose-Response Relationship, Drug
* Female
* Leptin
* Male
* Mice
* Mice, Obese
* Sympathetic Nervous System
* Tyrosine 3-Monooxygenase
* Uncoupling Protein 1
|keywords=* beige adipocytes
* leptin
* sympathetic nerve system
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7191411
}}
{{medline-entry
|title=Age-related sex differences in the expression of important disease-linked mitochondrial proteins in mice.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31806023
|mesh-terms=* Adipose Tissue, Brown
* Aging
* Animals
* Brain
* Female
* Male
* Mice, Inbred C57BL
* Mitochondrial Proteins
* Muscle, Skeletal
* Sex Characteristics
* Spleen
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6896328
}}
{{medline-entry
|title=An anti-inflammatory phenotype in visceral adipose tissue of old lean mice, augmented by exercise.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31427677
|mesh-terms=* Adipocytes
* Aging
* Animals
* Humans
* Inflammation
* Intra-Abdominal Fat
* Macrophages
* Mice
* Obesity
* Phenotype
* Physical Conditioning, Animal
* Resistance Training
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6700172
}}
==UGT2B28==
{{medline-entry
|title=Ages of hepatocellular carcinoma occurrence and life expectancy are associated with a [[UGT2B28]] genomic variation.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31805979
|mesh-terms=* Adult
* Age of Onset
* Aged
* Aged, 80 and over
* Carcinoma, Hepatocellular
* Female
* Genetic Association Studies
* Genetic Predisposition to Disease
* Glucuronosyltransferase
* Humans
* Life Expectancy
* Liver Neoplasms
* Male
* Middle Aged
* Neoplasm Metastasis
* Neoplasm Recurrence, Local
* Odds Ratio
* Polymorphism, Single Nucleotide
* Survival Analysis
* Young Adult
|keywords=* Alcoholism
* Xenobiotic metabolizing enzymes
* Young hepatocellular carcinoma; age of death
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6896495
}}
==USP7==
{{medline-entry
|title=Deubiquitinase [[USP7]] regulates [i]Drosophila[/i] aging through ubiquitination and autophagy.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/33221768
|keywords=* DMC
* Drosophila
* USP7
* aging
* autophagy
|full-text-url=https://sci-hub.do/10.18632/aging.104067
}}
==VCAM1==
{{medline-entry
|title=Sunitinib facilitates metastatic breast cancer spreading by inducing endothelial cell senescence.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32993785
|keywords=* Cell senescence
* Metastasis
* Metastatic breast cancer (MBC)
* Receptor tyrosine kinase (RTK)
* Sunitinib
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7526390
}}
==VDAC1==
{{medline-entry
|title=Low abundance of NDUFV2 and NDUFS4 subunits of the hydrophilic complex I domain and [[VDAC1]] predicts mammalian longevity.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32353747
|keywords=* Complex I
* Droplet digital PCR
* Longevity
* Mammals
* Mitochondria
* NDUFS4 subunit
* NDUFV2 subunit
* VDAC
* Western blot
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7191849
}}
{{medline-entry
|title=Changes in the expression of oxidative phosphorylation complexes in the aging intestinal mucosa.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32173460
|keywords=* Aging
* Colonic crypt
* Expression
* Intestine
* Mitochondria
* OXPHOS
|full-text-url=https://sci-hub.do/10.1016/j.exger.2020.110924
}}
==VDR==
{{medline-entry
|title=25-Hydroxyvitamin D  positively regulates periodontal inflammaging via SOCS3/STAT signaling in diabetic mice.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31917967
|keywords=* 25-Hydroxyvitamin D(3)
* Diabetic periodontitis
* Inflammaging
* SOCS3
* Senescence
* Senescence-associated secretory phenotypes
|full-text-url=https://sci-hub.do/10.1016/j.steroids.2019.108570
}}
{{medline-entry
|title=1,25-Dihydroxyvitamin D protects against age-related osteoporosis by a novel [[VDR]]-Ezh2-p16 signal axis.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31880094
|mesh-terms=* 25-Hydroxyvitamin D3 1-alpha-Hydroxylase
* Aging
* Animals
* Bone and Bones
* Cells, Cultured
* Cyclin-Dependent Kinase Inhibitor p16
* Cyclin-Dependent Kinase Inhibitor p19
* DNA Damage
* Enhancer of Zeste Homolog 2 Protein
* Female
* Histones
* Male
* Mesenchymal Stem Cells
* Mice
* Mice, Knockout
* Osteocytes
* Osteogenesis
* Osteoporosis
* Oxidative Stress
* Receptors, Calcitriol
* Vitamin D
|keywords=* Ezh2
* Vitamin D
* cellular senescence
* osteogenesis
* osteoporosis
* p16
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6996957
}}
{{medline-entry
|title=Active vitamin D impedes the progression of non-alcoholic fatty liver disease by inhibiting cell senescence in a rat model.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31810868
|keywords=* Active vitamin D
* Cell senescence
* Non-alcoholic fatty liver disease
* Oxidative stress
* P53-p21 signaling pathway
* Vitamin D receptor
|full-text-url=https://sci-hub.do/10.1016/j.clinre.2019.10.007
}}
==VEGFA==
{{medline-entry
|title=APOE ε4-specific associations of VEGF gene family expression with cognitive aging and Alzheimer's disease.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31791659
|mesh-terms=* Aged
* Aged, 80 and over
* Aging
* Apolipoprotein E4
* Cognitive Aging
* Cognitive Dysfunction
* Female
* Gene Expression
* Genetic Association Studies
* Genetic Predisposition to Disease
* Genotype
* Humans
* Male
* Neovascularization, Physiologic
* Neuropilin-1
* Vascular Endothelial Growth Factor A
|keywords=* APOE-ε4
* Aging
* Cognition
* Gene expression
* Vascular endothelial growth factor (VEGF)
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7064375
}}
==VGLL4==
{{medline-entry
|title=The lncRNA MEG3/miR-16-5p/[[VGLL4]] regulatory axis is involved in etoposide-induced senescence of tumor cells.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/33141998
|keywords=* LncRNA MEG3
* breast cancer
* cell senescence
* etoposide
* lung adenocarcinoma
|full-text-url=https://sci-hub.do/10.1002/jgm.3291
}}
==VHL==
{{medline-entry
|title=Hypoxic response regulators RHY-1 and EGL-9/PHD promote longevity through a [[VHL]]-1-independent transcriptional response.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32399915
|keywords=* Aging
* C. elegans
* EGL-9/PHD
* HIF-1 signaling
* Hypoxic response
* Lifespan
* RHY-1
|full-text-url=https://sci-hub.do/10.1007/s11357-020-00194-0
}}
==VIM==
{{medline-entry
|title=Establishment and characterization of a fibroblast cell line from postmortem skin of an adult Chinese muntjac (Muntiacus reevesi).
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31898011
|mesh-terms=* Aging
* Animals
* Cell Culture Techniques
* Cell Line
* Cell Proliferation
* Cell Shape
* Chromosomes, Mammalian
* Fibroblasts
* Male
* Muntjacs
* Postmortem Changes
* Skin
|keywords=* Characteristics
* Chinese muntjac
* Fibroblast cell line
* Postmortem skin
|full-text-url=https://sci-hub.do/10.1007/s11626-019-00422-8
}}
==VIP==
{{medline-entry
|title=Alterations in Intrinsic and Synaptic Properties of Hippocampal CA1 [[VIP]] Interneurons During Aging.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/33173468
|keywords=* VIP
* action potential
* aging
* calretinin
* circuit disinhibition
* hippocampus
* synapse
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7591401
}}
{{medline-entry
|title=Nutrition and exercise interventions could ameliorate age-related cognitive decline: a meta-analysis of randomized controlled trials.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/33052590
|keywords=* Aging
* Cognitive impairment
* Exercise
* Meta-analysis
* Nutrition
|full-text-url=https://sci-hub.do/10.1007/s40520-020-01730-w
}}
==VSIG4==
{{medline-entry
|title=Immune checkpoint protein [[VSIG4]] as a biomarker of aging in murine adipose tissue.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32856419
|keywords=* VSIG4
* adipose tissue
* aging
* frailty index
* immune checkpoint
* inflammation
* macrophage
* mouse
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7576241
}}
==WASL==
{{medline-entry
|title=Loss of Wasl improves pancreatic cancer outcome.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32434991
|keywords=* Cancer
* Cellular senescence
* Mouse models
* Oncology
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7259520
}}
==WDR5==
{{medline-entry
|title=Inhibition of the H3K4 methyltransferase MLL1/[[WDR5]] complex attenuates renal senescence in ischemia reperfusion mice by reduction of p16 .
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31570196
|mesh-terms=* Acute Kidney Injury
* Animals
* Biphenyl Compounds
* Cell Line
* Cyclin-Dependent Kinase Inhibitor p16
* Dihydropyridines
* Drug Evaluation, Preclinical
* Fibroblasts
* Histone-Lysine N-Methyltransferase
* Histones
* Intracellular Signaling Peptides and Proteins
* Male
* Mice, Inbred C57BL
* Myeloid-Lymphoid Leukemia Protein
* Rats
* Renal Insufficiency
* Reperfusion Injury
|keywords=* H3K4me3
* MLL1
* WDR5
* acute kidney injury
* p16(INK4a)
* senescence
|full-text-url=https://sci-hub.do/10.1016/j.kint.2019.06.021
}}
==WFDC2==
{{medline-entry
|title=Differences in biomarkers and molecular pathways according to age for patients with HFrEF.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/33002110
|keywords=* aging
* biological age
* biomarkers
* chronological age
* heart failure with reduced ejection fraction
|full-text-url=https://sci-hub.do/10.1093/cvr/cvaa279
}}
==WIPI2==
{{medline-entry
|title=Neuronal autophagy declines substantially with age and is rescued by overexpression of [[WIPI2]].
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31794336
|mesh-terms=* Aging
* Animals
* Autophagy
* Autophagy-Related Proteins
* Mice, Transgenic
* Models, Biological
* Neurons
* Phagosomes
* Phosphate-Binding Proteins
* RNA, Messenger
|keywords=* Aging
* WIPI2
* autophagosome biogenesis
* autophagy
* macroautophagy
* neurodegeneration
* neuronal autophagy
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6984449
}}
==WNT1==
{{medline-entry
|title=Plasma proteomic profile of age, health span, and all-cause mortality in older adults.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/33089916
|keywords=* SomaScan® assay
* aging
* proteomics
* weighted gene co-expression network analysis
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7681045
}}
==WNT10A==
{{medline-entry
|title=Dysregulation of the Wnt Signaling Pathway and Synovial Stem Cell Dysfunction in Osteoarthritis Development.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31964233
|keywords=* Wnt signaling pathway
* cell senescence
* differentiation
* osteoarthritis
* synovial mesenchymal stem cells (SMSCs)
|full-text-url=https://sci-hub.do/10.1089/scd.2019.0260
}}
==WNT3A==
{{medline-entry
|title=Chronic WNT/β-catenin signaling induces cellular senescence in lung epithelial cells.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32109549
|keywords=* ATII cells
* Aging
* Cellular senescence
* IPF
* WNT signaling
|full-text-url=https://sci-hub.do/10.1016/j.cellsig.2020.109588
}}
==WNT7A==
{{medline-entry
|title=Exogenous Expression of [[WNT7A]] in Leukemia-Derived Cell Lines Induces Resistance to Chemotherapeutic Agents.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32436833
|keywords=* WNT signaling
* WNT7A
* cell cycle
* chemotherapeutic agents
* leukemias
* senescence
|full-text-url=https://sci-hub.do/10.2174/1871520620666200521114100
}}
==WRN==
{{medline-entry
|title=The Impact of Vitamin C on Different System Models of Werner Syndrome.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/33202145
|keywords=* Werner syndrome
* aging
* mouse
* stem cells
* vitamin C
* worm
|full-text-url=https://sci-hub.do/10.1089/ars.2020.8147
}}
{{medline-entry
|title=[[WRN]] modulates translation by influencing nuclear mRNA export in HeLa cancer cells.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/33054770
|keywords=* Cancer
* NXF1 export receptor
* Senescence
* Translation
* Werner syndrome protein
* mRNA export
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7557079
}}
{{medline-entry
|title=MIB1-mediated degradation of [[WRN]] promotes cellular senescence in response to camptothecin treatment.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32652764
|keywords=* CPT
* Mind bomb 1
* Werner syndrome protein
* aging
* protein stability
|full-text-url=https://sci-hub.do/10.1096/fj.202000268RRR
}}
{{medline-entry
|title=A Case Report of Werner's Syndrome With a Novel Mutation From India.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32528764
|keywords=* aging
* novel mutation
* progeria
* werner syndrome
* wrn gene
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7282380
}}
{{medline-entry
|title=Evidence for premature aging in a Drosophila model of Werner syndrome.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31518666
|mesh-terms=* Aging, Premature
* Animals
* Behavior, Animal
* Body Composition
* Body Weight
* DNA Repair
* Drosophila
* Drosophila Proteins
* Exonucleases
* Female
* Gastrointestinal Neoplasms
* Male
* Motor Activity
* Muscle Weakness
* Mutation
* Phenotype
* Werner Syndrome
|keywords=* Aging
* DNA repair
* Locomotor function
* Tumor
* Werner syndrome
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6935377
}}
==WT1==
{{medline-entry
|title=Age and weight at first mating affects plasma leptin concentration but no effects on reproductive performance of gilts.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31602307
|keywords=* Backfat
* Gilts
* Leptin
* Litter performance
* Longevity
* Mating
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6778857
}}
==WWP1==
{{medline-entry
|title=The ubiquitin ligase [[WWP1]] contributes to shifts in matrix proteolytic profiles and a myocardial aging phenotype with diastolic heart.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32822210
|mesh-terms=* Age Factors
* Animals
* Cells, Cultured
* Diastole
* Disease Models, Animal
* Extracellular Matrix
* Female
* Fibroblasts
* Heart Failure
* Hypertrophy, Left Ventricular
* Male
* Mice, Inbred C57BL
* Mice, Transgenic
* Myocardium
* Phenotype
* Proteolysis
* Stroke Volume
* Ubiquitin-Protein Ligases
* Ventricular Dysfunction, Left
* Ventricular Function, Left
* Ventricular Remodeling
|keywords=* aging
* cardiac hypertrophy
* diastolic dysfunction
* heart failure
* ventricular remodeling
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7717125
}}
==XBP1==
{{medline-entry
|title=Age-dependent impairment of adipose-derived stem cells isolated from horses.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31900232
|keywords=* Aging
* Endoplasmic reticulum stress
* Equine adipose-derived mesenchymal stem cells
* Insulin resistance
* Pro-inflammatory cytokines
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6942290
}}
==XDH==
{{medline-entry
|title=Enhancing xanthine dehydrogenase activity is an effective way to delay leaf senescence and increase rice yield.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32162142
|keywords=* Allantoin
* Reactive oxygen species
* Rice (Oryza sativa L.)
* Senescence
* Xanthine dehydrogenase
* Yield
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7065298
}}
==ZC3H12A==
{{medline-entry
|title=Keratinocyte-specific ablation of Mcpip1 impairs skin integrity and promotes local and systemic inflammation.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31786670
|mesh-terms=* Aging
* Animals
* Calgranulin A
* Cell Differentiation
* Cell Proliferation
* Cells, Cultured
* Cornified Envelope Proline-Rich Proteins
* Epidermis
* Gene Expression Regulation
* Gene Ontology
* Inflammation
* Interleukin-1
* Keratinocytes
* Keratins
* Lymph Nodes
* Mice
* Mice, Inbred C57BL
* Mice, Transgenic
* Proliferating Cell Nuclear Antigen
* Ribonucleases
* Skin
* Spleen
* Transcriptome
|keywords=* MCPIP1
* Regnase-1
* Skin inflammation
* ZC3H12A
|full-text-url=https://sci-hub.do/10.1007/s00109-019-01853-2
}}
==ZEB2==
{{medline-entry
|title=miR-200b regulates cellular senescence and inflammatory responses by targeting [[ZEB2]] in pulmonary emphysema.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32070140
|mesh-terms=* Animals
* Cell Line
* Cellular Senescence
* Disease Models, Animal
* Gene Expression
* Gene Expression Regulation
* Inflammation
* Lung
* Mice
* MicroRNAs
* Pulmonary Emphysema
* Zinc Finger E-box Binding Homeobox 2
|keywords=* ZEB2
* cellular senescence
* inflammation
* miR-200b
* pulmonary emphysema
|full-text-url=https://sci-hub.do/10.1080/21691401.2020.1725029
}}
==ZMPSTE24==
{{medline-entry
|title=Bone marrow-derived mesenchymal stem cells in three-dimensional co-culture attenuate degeneration of nucleus pulposus cells.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31666429
|mesh-terms=* Bone Marrow Cells
* Cell Cycle
* Cell Proliferation
* Cell Survival
* Cells, Cultured
* Cellular Senescence
* Coculture Techniques
* Collagen Type II
* Female
* Humans
* Intervertebral Disc Degeneration
* Male
* Matrix Metalloproteinase 9
* Membrane Proteins
* Mesenchymal Stem Cells
* Metalloendopeptidases
* Middle Aged
* Nucleus Pulposus
* Signal Transduction
* Transcription Factor RelA
* Up-Regulation
* beta-Galactosidase
|keywords=* 3D co-culture
* ZMPSTE24
* bone marrow-derived mesenchymal stem cells
* nucleus pulposus
* senescence
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6834418
}}
}}

Текущая версия от 18:03, 26 марта 2021


A2M[править]

Age-Dependent Variation in Glycosylation Features of Alpha-2-Macroglobulin.


MeSH Terms

  • Adult
  • Aging
  • Electrophoresis, Gel, Two-Dimensional
  • Glycosylation
  • Humans
  • Infant, Newborn
  • Polysaccharides
  • Pregnancy-Associated alpha 2-Macroglobulins
  • Protein Isoforms
  • Umbilical Cord

Keywords

  • Alpha-2-macroglobulin
  • Glycosylation
  • Newborn
  • Plasma

AACS[править]

Sex differences in subjective age-associated changes in sleep: a prospective elderly cohort study.


Keywords

  • aging
  • longitudinal studies
  • normative
  • self-report
  • sex characteristics

ABCG2[править]

Contribution of senescence in human endometrial stromal cells during proliferative phase to embryo receptivity†.


Keywords

  • cellular senescence
  • embryo receptivity
  • endometrial stem cell
  • human endometrial stromal cell
  • infertility


ABCG2 rs2231142 variant in hyperuricemia is modified by SLC2A9 and SLC22A12 polymorphisms and cardiovascular risk factors in an elderly community-dwelling population.


MeSH Terms

  • ATP Binding Cassette Transporter, Subfamily G, Member 2
  • Aged
  • Aged, 80 and over
  • Aging
  • Cardiovascular Diseases
  • China
  • Cohort Studies
  • Effect Modifier, Epidemiologic
  • Epistasis, Genetic
  • Female
  • Genes, Modifier
  • Genetic Predisposition to Disease
  • Genome-Wide Association Study
  • Glucose Transport Proteins, Facilitative
  • Humans
  • Hyperuricemia
  • Independent Living
  • Male
  • Neoplasm Proteins
  • Organic Anion Transporters
  • Organic Cation Transport Proteins
  • Polymorphism, Single Nucleotide
  • Risk Factors
  • Uric Acid

Keywords

  • ABCG2
  • Hypertension
  • Polymorphisms
  • Triglyceridemia
  • Uric acid

ABL1[править]

European LeukemiaNet 2020 recommendations for treating chronic myeloid leukemia.


MeSH Terms

  • Aniline Compounds
  • Antineoplastic Agents
  • Clinical Decision-Making
  • Consensus Development Conferences as Topic
  • Dasatinib
  • Disease Management
  • Fusion Proteins, bcr-abl
  • Gene Expression
  • Humans
  • Imatinib Mesylate
  • Leukemia, Myelogenous, Chronic, BCR-ABL Positive
  • Life Expectancy
  • Monitoring, Physiologic
  • Nitriles
  • Protein Kinase Inhibitors
  • Pyrimidines
  • Quality of Life
  • Quinolines
  • Survival Analysis

ABO[править]

Allelic distribution of [i]ABO[/i] gene in Chinese centenarians.


Keywords

  • ABO gene
  • centenarian
  • longevity
  • single nucleotide polymorphisms


Genetically Determined ABO Blood Group and its Associations With Health and Disease.


MeSH Terms

  • ABO Blood-Group System
  • Adult
  • Age Factors
  • Aged
  • Cardiovascular Diseases
  • Female
  • Gene Frequency
  • Genetic Predisposition to Disease
  • Health Status
  • Healthy Aging
  • Humans
  • Incidence
  • Male
  • Middle Aged
  • Phenotype
  • Polymorphism, Single Nucleotide
  • Prevalence
  • Risk Assessment
  • Risk Factors
  • United Kingdom

Keywords

  • ABO
  • aging
  • blood
  • genetics
  • hypertension
  • phenotype

ABR[править]

[Hidden hearing loss and early identification].


MeSH Terms

  • Acoustic Stimulation
  • Audiometry, Pure-Tone
  • Auditory Threshold
  • Evoked Potentials, Auditory, Brain Stem
  • Hearing Loss, Noise-Induced
  • Humans
  • Noise

Keywords

  • aging
  • drug damage
  • hidden hearing loss
  • noise exposure


Aging But Not Age-Related Hearing Loss Dominates the Decrease of Parvalbumin Immunoreactivity in the Primary Auditory Cortex of Mice.


Keywords

  • age-related hearing loss
  • aging
  • mouse primary auditoy cortex
  • parvalbumin


Hearing loss through apoptosis of the spiral ganglion neurons in apolipoprotein E knockout mice fed with a western diet.


MeSH Terms

  • Aging
  • Animals
  • Apolipoproteins E
  • Apoptosis
  • Diet, Western
  • Disease Models, Animal
  • Hearing Loss
  • Male
  • Mice
  • Mice, Inbred C57BL
  • Mice, Knockout
  • Neurons
  • Spiral Ganglion

Keywords

  • Apoptosis
  • Atherosclerosis
  • Hearing loss
  • Reactive oxygen specie
  • Spiral ganglion neurons


Effects of enriched endogenous omega-3 fatty acids on age-related hearing loss in mice.


MeSH Terms

  • Aging
  • Animals
  • Body Weight
  • Caenorhabditis elegans Proteins
  • Cochlea
  • Evoked Potentials, Auditory, Brain Stem
  • Fatty Acid Desaturases
  • Fatty Acids, Omega-3
  • Male
  • Mice
  • Mice, Inbred C57BL
  • Mice, Transgenic
  • Neurons
  • Presbycusis
  • Spiral Ganglion

Keywords

  • Age-related hearing loss
  • C57BL/6 mouse
  • Cochlea
  • Omega-3 (n-3) fatty acids


Hearing impairment and associated morphological changes in pituitary adenylate cyclase activating polypeptide (PACAP)-deficient mice.


MeSH Terms

  • Aging
  • Animals
  • Cochlea
  • Evoked Potentials, Auditory, Brain Stem
  • Genotype
  • Hearing
  • Hearing Loss
  • Inflammation
  • Male
  • Mice
  • Mice, Knockout
  • Models, Animal
  • Neovascularization, Pathologic
  • Neurons
  • Pituitary Adenylate Cyclase-Activating Polypeptide
  • Proteome
  • Proto-Oncogene Proteins c-fos


Global nurse/midwife workforce and reproductive health through social ecology lens.


MeSH Terms

  • Adolescent
  • Cross-Sectional Studies
  • Employment
  • Female
  • Global Health
  • Health Education
  • Humans
  • Income
  • Life Expectancy
  • Male
  • Midwifery
  • Pregnancy
  • Reproductive Health
  • Social Environment
  • Socioeconomic Factors
  • Workforce

Keywords

  • global health
  • nurse/midwife workforce
  • reproductive health
  • social ecology

ACD[править]

Genetics of cognitive trajectory in Brazilians: 15 years of follow-up from the Bambuí-Epigen Cohort Study of Aging.


MeSH Terms

  • Age Factors
  • Aged
  • Aging
  • Brazil
  • Cognition
  • Cognitive Dysfunction
  • Cohort Studies
  • Female
  • Follow-Up Studies
  • Genetic Predisposition to Disease
  • Genome-Wide Association Study
  • Humans
  • Male
  • Middle Aged
  • Polymorphism, Single Nucleotide

ACE[править]

Elite swimmers possess shorter telomeres than recreationally active controls.


Keywords

  • Aging
  • Athlete
  • Exercise
  • Genetics


Coronavirus Disease-2019 Conundrum: RAS Blockade and Geriatric-Associated Neuropsychiatric Disorders.


Keywords

  • ACE2
  • ACEIs
  • ARBs
  • COVID-19
  • RAS
  • SARS-CoV-2
  • geriatrics
  • neuropsychiatric disorders


Pregnancy Protects Hyperandrogenemic Female Rats From Postmenopausal Hypertension.


Keywords

  • aging
  • endothelin
  • menopause
  • nitric oxide
  • renin-angiotensin system


Heart failure is associated with accelerated age related metabolic bone disease.


Keywords

  • Heart failure
  • comorbidities
  • geriatrics
  • metabolic bone disease
  • osteoporosis


Management of heart failure: an Italian national survey on fellows/specialists in geriatrics.


MeSH Terms

  • Aged
  • Geriatrics
  • Heart Failure
  • Humans
  • Italy
  • Specialization
  • Stroke Volume
  • Surveys and Questionnaires

Keywords

  • Aged, 65 years or over
  • Care survey
  • Health
  • Heart failure


Angiotensin-Converting Enzyme (ACE) genetic variation and longevity in Peruvian older people: a cross-sectional study.


MeSH Terms

  • Aged
  • Aged, 80 and over
  • Cross-Sectional Studies
  • Female
  • Genetic Variation
  • Humans
  • Longevity
  • Male
  • Middle Aged
  • Peptidyl-Dipeptidase A
  • Peru
  • Polymorphism, Genetic

Keywords

  • ACE gene
  • Longevity
  • Perú
  • ageing


COVID-19 and chronological aging: senolytics and other anti-aging drugs for the treatment or prevention of corona virus infection?


MeSH Terms

  • Age Factors
  • Aged
  • Aged, 80 and over
  • Aging
  • Angiotensin-Converting Enzyme 2
  • Antiviral Agents
  • Azithromycin
  • Betacoronavirus
  • COVID-19
  • Coronavirus Infections
  • Dipeptidyl Peptidase 4
  • Humans
  • Hydroxychloroquine
  • Pandemics
  • Peptidyl-Dipeptidase A
  • Pneumonia, Viral
  • Quercetin
  • Receptors, Virus
  • SARS-CoV-2

Keywords

  • Azithromycin
  • COVID-19
  • Doxycycline
  • Hydroxy-chloroquine
  • Quercetin
  • Rapamycin
  • aging
  • antibiotic
  • corona virus
  • drug repurposing
  • prevention
  • senescence
  • senolytic drug therapy
  • viral replication


[i]A[/i]ngiotensin Converting Enzyme Inhibitors [i]C[/i]ombined with [i]E[/i]xercise for Hypertensive [i]S[/i]eniors (The ACES Trial): Study Protocol of a Randomized Controlled Trial.


Keywords

  • aging
  • antihypertensive
  • exercise
  • functional status
  • hypertension


Vascular age.


MeSH Terms

  • Adolescent
  • Adult
  • Aged
  • Aging
  • Angiotensin-Converting Enzyme Inhibitors
  • Atherosclerosis
  • Child
  • Elasticity
  • Humans
  • Middle Aged
  • Perindopril
  • Pulse Wave Analysis
  • Vascular Stiffness
  • Young Adult

Keywords

  • ACE inhibitors
  • CT angiography
  • atorvastatin
  • dyslipidemia
  • hypertension
  • intima media thickness (IMT)
  • perindopril
  • pulse wave velocity (PWV)
  • statins
  • vascular age

ACE2[править]

How Does SARS-CoV-2 Affect the Central Nervous System? A Working Hypothesis.


Keywords

  • ACE2
  • Alzheimer disease
  • Ang(1-7)/Mas
  • COVID-19
  • RAAS
  • SARS-CoV
  • brain aging
  • neurodegenerative and psychiatric disorders abstract


Bioinformatic characterization of angiotensin-converting enzyme 2, the entry receptor for SARS-CoV-2.


MeSH Terms

  • Aging
  • Angiotensin-Converting Enzyme 2
  • Betacoronavirus
  • Binding Sites
  • COVID-19
  • Carrier Proteins
  • Computational Biology
  • Coronavirus Infections
  • Female
  • Gene Expression Regulation, Enzymologic
  • Gene Ontology
  • Humans
  • Interferons
  • Lung
  • Male
  • Metalloproteases
  • Neovascularization, Physiologic
  • Organ Specificity
  • Pandemics
  • Peptidyl-Dipeptidase A
  • Pneumonia, Viral
  • Promoter Regions, Genetic
  • RNA, Messenger
  • Receptors, Virus
  • Renin-Angiotensin System
  • SARS-CoV-2
  • Sex Characteristics
  • Single-Cell Analysis
  • Transcription Factors
  • Transcription Initiation Site
  • Virus Attachment


A mouse-adapted model of SARS-CoV-2 to test COVID-19 countermeasures.


MeSH Terms

  • Aging
  • Angiotensin-Converting Enzyme 2
  • Animals
  • Betacoronavirus
  • COVID-19
  • COVID-19 Vaccines
  • Coronavirus Infections
  • Disease Models, Animal
  • Female
  • Forkhead Transcription Factors
  • Humans
  • Interferon-alpha
  • Interferons
  • Interleukins
  • Male
  • Mice
  • Mice, Inbred BALB C
  • Mice, Transgenic
  • Models, Molecular
  • Pandemics
  • Peptidyl-Dipeptidase A
  • Pneumonia, Viral
  • Receptors, Virus
  • SARS-CoV-2
  • Viral Vaccines


COVID-19 and Senotherapeutics: Any Role for the Naturally-occurring Dipeptide Carnosine?


Keywords

  • acetyl-carnosine
  • aging
  • carnosine
  • inflammation
  • lungs
  • olfaction
  • virus


The dual impact of ACE2 in COVID-19 and ironical actions in geriatrics and pediatrics with possible therapeutic solutions.


MeSH Terms

  • Age Factors
  • Aged
  • Aged, 80 and over
  • Angiotensin-Converting Enzyme 2
  • Anti-Inflammatory Agents
  • Betacoronavirus
  • COVID-19
  • Child
  • Child, Preschool
  • Coronavirus
  • Coronavirus Infections
  • Female
  • Geriatrics
  • Humans
  • Infant
  • Infant, Newborn
  • Male
  • Pandemics
  • Pediatrics
  • Peptidyl-Dipeptidase A
  • Pneumonia, Viral
  • Protein Binding
  • Receptors, Virus
  • Renin-Angiotensin System
  • SARS-CoV-2
  • Severe Acute Respiratory Syndrome
  • Virus Internalization

Keywords

  • ACE2
  • Angiotensin 2
  • Angiotensin-(1–7)
  • Corona virus
  • Glycoprotein spikes
  • RAAS system


The possible pathophysiology mechanism of cytokine storm in elderly adults with COVID-19 infection: the contribution of "inflame-aging".


MeSH Terms

  • Adipocytes
  • Age Factors
  • Aged
  • Aging
  • Angiotensin II Type 2 Receptor Blockers
  • Autophagy
  • Betacoronavirus
  • COVID-19
  • Cellular Senescence
  • Coronavirus Infections
  • Cytokine Release Syndrome
  • Cytokines
  • Humans
  • Immune System
  • Inflammation
  • Pandemics
  • Pneumonia, Viral
  • Reactive Oxygen Species
  • Receptor, Angiotensin, Type 2
  • SARS-CoV-2
  • Vitamin D
  • Vitamin D Deficiency

Keywords

  • ACE2 receptor
  • Autophagy
  • COVID-19
  • Cytokine storm
  • Senescent cell
  • Vitamin D


Decoding SARS-CoV-2 hijacking of host mitochondria in COVID-19 pathogenesis.


MeSH Terms

  • Adaptive Immunity
  • Angiotensin-Converting Enzyme 2
  • Animals
  • Betacoronavirus
  • COVID-19
  • Coronavirus Infections
  • DNA, Mitochondrial
  • Gene Expression Regulation, Viral
  • Host Microbial Interactions
  • Humans
  • Immunity, Innate
  • Mitochondria
  • Pandemics
  • Peptidyl-Dipeptidase A
  • Pneumonia, Viral
  • RNA, Viral
  • SARS-CoV-2
  • Virus Replication

Keywords

  • COVID-19
  • SARS-CoV
  • aging
  • coronavirus
  • mitochondria
  • mitochondrial DNA


A Mouse Model of SARS-CoV-2 Infection and Pathogenesis.


MeSH Terms

  • Aging
  • Angiotensin-Converting Enzyme 2
  • Animals
  • Betacoronavirus
  • Brain
  • COVID-19
  • CRISPR-Cas Systems
  • Coronavirus Infections
  • Cytokines
  • Disease Models, Animal
  • Gene Knock-In Techniques
  • Lung
  • Lung Diseases, Interstitial
  • Mice, Inbred C57BL
  • Nose
  • Pandemics
  • Peptidyl-Dipeptidase A
  • Pneumonia, Viral
  • RNA, Viral
  • SARS-CoV-2
  • Stomach
  • Trachea
  • Viral Load
  • Virus Replication

Keywords

  • SARS-CoV-2
  • angiotensin-converting enzyme II
  • hACE2-KI/NIFDC
  • mouse model
  • pathogenesis


COVID-19-associated cardiovascular morbidity in older adults: a position paper from the Italian Society of Cardiovascular Researches.


MeSH Terms

  • Age Factors
  • Aged
  • Betacoronavirus
  • COVID-19
  • Cardiovascular Diseases
  • Coronavirus Infections
  • Female
  • Humans
  • Italy
  • Male
  • Middle Aged
  • Pandemics
  • Pneumonia, Viral
  • Risk Factors
  • SARS-CoV-2

Keywords

  • Acute myocardial injury
  • Aging
  • COVID-19
  • Cardiovascular system
  • Frailty
  • SARS-CoV-2


Gut microbiota and Covid-19- possible link and implications.


MeSH Terms

  • Aging
  • Betacoronavirus
  • COVID-19
  • Coronavirus Infections
  • Diet
  • Dysbiosis
  • Gastrointestinal Microbiome
  • Gastrointestinal Tract
  • Homeostasis
  • Humans
  • Immunity
  • Lung
  • Pandemics
  • Pneumonia, Viral
  • SARS-CoV-2

Keywords

  • Covid-19
  • Diet
  • Dysbiosis
  • Gut microbiome
  • Immunity
  • Lung microbiota
  • SARS-CoV-2


Inflamm-aging: Why older men are the most susceptible to SARS-CoV-2 complicated outcomes.


MeSH Terms

  • Aged
  • Aged, 80 and over
  • Aging
  • Angiotensin-Converting Enzyme 2
  • Antibodies, Monoclonal, Humanized
  • Betacoronavirus
  • COVID-19
  • Comorbidity
  • Coronavirus Infections
  • Female
  • Humans
  • Inflammation
  • Interferon Type I
  • Interleukin-6
  • Male
  • Pandemics
  • Peptidyl-Dipeptidase A
  • Pneumonia, Viral
  • SARS-CoV-2
  • Severe Acute Respiratory Syndrome

Keywords

  • COVID-19
  • Cardiovascular diseases
  • Host-directed therapies
  • Inflamm-aging
  • SARS-CoV-2
  • interleukin-6


Restoration of the Renin-Angiotensin System Balance Is a Part of the Effect of Fasting on Cardiovascular Rejuvenation: Role of Age and Fasting Models.


Keywords

  • aging
  • cardiac hypertrophy index
  • intermittent fasting
  • renin–angiotensin system (RAS)


Angiotensin 1-7 alleviates aging-associated muscle weakness and bone loss, but is not associated with accelerated aging in ACE2-knockout mice.


MeSH Terms

  • Adipose Tissue
  • Aging
  • Angiotensin I
  • Angiotensin-Converting Enzyme 2
  • Animals
  • Body Weight
  • Bone Resorption
  • Cyclin-Dependent Kinase Inhibitor p16
  • Forelimb
  • Gene Deletion
  • Hand Strength
  • Male
  • Mice, Inbred C57BL
  • Mice, Knockout
  • Muscle Weakness
  • Muscles
  • Organ Size
  • PAX3 Transcription Factor
  • Peptide Fragments
  • Peptidyl-Dipeptidase A
  • Proto-Oncogene Proteins
  • Receptors, G-Protein-Coupled
  • Renin-Angiotensin System
  • Time Factors

Keywords

  • Angiotensin 1-7
  • Angiotensin Converting Enzyme 2
  • Mas receptor
  • Muscle weakness
  • osteoporosis

ACLY[править]

In S. cerevisiae hydroxycitric acid antagonizes chronological aging and apoptosis regardless of citrate lyase.


Keywords

  • Aging
  • Apoptosis/necrosis
  • Caloric restriction mimetics
  • Hydroxycitric acid
  • Oxidative stress
  • Sch9 and Ras2 pathways

ACR[править]

Progenitor cell niche senescence reflects pathology of the parotid salivary gland in primary Sjögren's syndrome.


Keywords

  • p16
  • primary Sjögren’s syndrome
  • salivary gland
  • salivary gland progenitor cells
  • senescence


Jumping Joints: The Complex Relationship Between Osteoarthritis and Jumping Mechanography.


Keywords

  • Aging
  • Jumping mechanography
  • Muscle
  • Osteoarthritis
  • Sarcopenia

ACVR1[править]

Fibrodysplasia Ossificans Progressiva (FOP): A Segmental Progeroid Syndrome.


Keywords

  • ACVR1
  • activin A
  • cell senescence
  • fibrodysplasia ossificans progressiva
  • progeroid syndrome

ADA[править]

Adenosine Metabolism in the Cerebral Cortex from Several Mice Models during Aging.


Keywords

  • adenosine metabolism
  • aging
  • animal models
  • glutamate
  • purinergic signaling

ADAM10[править]

NKG2D Ligand Shedding in Response to Stress: Role of ADAM10.


Keywords

  • ADAM10
  • NKG2D
  • NKG2D ligands
  • cancer
  • chemotherapy
  • senescence
  • shedding


Chronic Mild Stress Modified Epigenetic Mechanisms Leading to Accelerated Senescence and Impaired Cognitive Performance in Mice.


MeSH Terms

  • ADAM10 Protein
  • Aging
  • Amyloid Precursor Protein Secretases
  • Animals
  • Cognition
  • Epigenesis, Genetic
  • Female
  • Glial Fibrillary Acidic Protein
  • Glycogen Synthase Kinase 3 beta
  • Mechanistic Target of Rapamycin Complex 1
  • Membrane Proteins
  • Mice
  • MicroRNAs
  • NF-kappa B
  • Reactive Oxygen Species
  • Signal Transduction
  • Stress, Psychological

Keywords

  • Alzheimer’s disease
  • SAMP8
  • SAMR1
  • age-related cognitive decline
  • autophagy
  • cognition
  • epigenetics
  • inflammation
  • oxidative stress
  • senescence
  • stress

ADAM17[править]

ACE2/ADAM17/TMPRSS2 Interplay May Be the Main Risk Factor for COVID-19.


MeSH Terms

  • ADAM17 Protein
  • Aged
  • Aging
  • Angiotensin-Converting Enzyme 2
  • Betacoronavirus
  • COVID-19
  • Comorbidity
  • Coronavirus Infections
  • Female
  • Humans
  • Male
  • Pandemics
  • Peptidyl-Dipeptidase A
  • Pneumonia, Viral
  • Receptors, Interleukin-6
  • Risk Factors
  • SARS-CoV-2
  • Serine Endopeptidases
  • Tumor Necrosis Factor-alpha

Keywords

  • ACE2
  • ADAM17
  • COVID-19 pathophysiology
  • SARS-CoV-2
  • TMPRSS2

ADH5[править]

Can Serum Nitrosoproteome Predict Longevity of Aged Women?


Keywords

  • aging
  • cardiovascular disease
  • muscle atrophy
  • nitrosative stress
  • proteomics

ADM[править]

Assessment of age-related differences in decomposition-based quantitative EMG in the intrinsic hand muscles: A multivariate approach.


Keywords

  • Aging
  • Decomposition-based quantitative electromyography (DQEMG)
  • Hand muscle
  • Jiggle
  • Motor unit potential (MUP)
  • Multivariate


Evaluation of transcriptional levels of the natriuretic peptides, endothelin-1, adrenomedullin, their receptors and long non-coding RNAs in rat cardiac tissue as cardiovascular biomarkers of aging.


Keywords

  • ADM system
  • Aging
  • Biomarkers
  • ET-1system
  • LncRNA
  • NP system

ADORA2B[править]

Adenosine A2B receptor: A pathogenic factor and a therapeutic target for sensorineural hearing loss.


Keywords

  • ADA-deficiency
  • adenosine deaminase deficiency
  • aging
  • myelin protein zero
  • myelination

ADRA2A[править]

α2A-Adrenergic Receptor Inhibits the Progression of Cervical Cancer Through Blocking PI3K/AKT/mTOR Pathway.


Keywords

  • ADRA2A
  • PI3K/Akt/mTOR pathway
  • cervical cancer
  • metastasis
  • proliferation
  • senescence

AFM[править]

Photocatalytic aging process of Nano-TiO coated polypropylene microplastics: Combining atomic force microscopy and infrared spectroscopy (AFM-IR) for nanoscale chemical characterization.


Keywords

  • AFM-IR
  • Aging process
  • Microplastics
  • Nanoscale characterization
  • Polypropylene


Nanoscale infrared, thermal and mechanical properties of aged microplastics revealed by an atomic force microscopy coupled with infrared spectroscopy (AFM-IR) technique.


Keywords

  • AFM-IR
  • Aging process
  • Mechanical properties
  • Microplastics (MPs)
  • Thermal analysis


Detecting zeta potential of polydimethylsiloxane (PDMS) in electrolyte solutions with atomic force microscope.


Keywords

  • AFM
  • Air plasma treatment
  • Liquid aging
  • PDMS
  • Zeta potential


Recent Applications of Advanced Atomic Force Microscopy in Polymer Science: A Review.


Keywords

  • AFM-IR
  • blends
  • nanoscale characterization
  • polymer aging
  • polymer composites
  • polymers


Active fractions of mannoproteins derived from yeast cell wall stimulate innate and acquired immunity of adult and elderly dogs.


Keywords

  • AFM, active fraction of mannoproteins
  • ALP, alkaline phosphatase
  • ALT, alanine aminotransferase
  • Ageing
  • CBC, complete blood count
  • CD21+, B lymphocyte
  • CD4+, auxiliary T lymphocyte
  • CD5+, total T lymphocyte
  • CD8+, cytotoxic lymphocyte
  • CO, cells only
  • Canine
  • DCHT, delayed cutaneous hypersensitivity test
  • FOSs, fructooligosaccharides
  • GALT, gut-associated lymphoid tissue
  • IL-12, interleukin 12
  • IgA, immunoglobulin A
  • Immunosenescence
  • LPS, bacterial lipopolysaccharide
  • MOSs, mannanoligosaccharides
  • NADPH, reduced nicotinamide adenine dinucleotide phosphate
  • NO, nitrogen monoxide
  • NOS, nitric oxide synthase
  • OD, optical density
  • PMA, phorbol myristate acetate
  • Saccharomyces cerevisiae
  • Senescence
  • TNF-α, tumour necrosis factor alpha
  • Th1, helper T lymphocyte


The Effect of Waste Engine Oil and Waste Polyethylene on UV Aging Resistance of Asphalt.


Keywords

  • Fourier transform infrared spectroscopy
  • atomic force microscopy
  • gel permeation chromatography
  • ultraviolet aging
  • waste engine oil
  • waste polyethylene


Mechanical properties measured by atomic force microscopy define health biomarkers in ageing C. elegans.


MeSH Terms

  • Aging
  • Animal Feed
  • Animals
  • Bacillus subtilis
  • Biomarkers
  • Caenorhabditis elegans
  • Caenorhabditis elegans Proteins
  • Comamonas
  • Escherichia coli
  • Forkhead Transcription Factors
  • Hot Temperature
  • Insulin
  • Microbiota
  • Microscopy, Atomic Force
  • Mutation
  • Receptor, Insulin
  • Signal Transduction
  • Ultraviolet Rays


Nanomechanical insights: Amyloid beta oligomer-induced senescent brain endothelial cells.


MeSH Terms

  • Alzheimer Disease
  • Amyloid beta-Peptides
  • Biomechanical Phenomena
  • Brain
  • Cell Culture Techniques
  • Cell Membrane
  • Cellular Senescence
  • Endothelial Cells
  • Endothelium, Vascular
  • Humans
  • Microscopy, Atomic Force
  • Vascular Endothelial Growth Factor A

Keywords

  • Amyloid beta oligomer
  • Atomic force microscopy
  • Brain endothelial cells
  • Nanoindentation
  • Nanomechanical properties
  • Senescence

AGER[править]

Vitamin D3 regulates apoptosis and proliferation in the testis of D-galactose-induced aged rat model.


MeSH Terms

  • Aging
  • Animals
  • Antioxidants
  • Apoptosis
  • Cell Proliferation
  • Cholecalciferol
  • Down-Regulation
  • Galactose
  • Male
  • Oxidative Stress
  • Rats
  • Spermatogenesis
  • Testis

AGT[править]

SQSTM1/p62 and PPARGC1A/PGC-1alpha at the interface of autophagy and vascular senescence.


Keywords

  • Aging
  • SQSTM1
  • autophagy
  • oxidative stress
  • senescence
  • vascular biology

AHR[править]

Indoles from the commensal microbiota act via the AHR and IL-10 to tune the cellular composition of the colonic epithelium during aging.


MeSH Terms

  • Aging
  • Animals
  • Bacteria
  • Cell Differentiation
  • Epithelial Cells
  • Female
  • Goblet Cells
  • Indoles
  • Interleukin-10
  • Interleukins
  • Male
  • Mice
  • Mice, Inbred BALB C
  • Mice, Inbred C57BL
  • Mice, Knockout
  • Microbiota
  • Mucus
  • Receptors, Aryl Hydrocarbon
  • Signal Transduction

Keywords

  • aging
  • goblet cell
  • intestinal homeostasis
  • mucus


Role of the Aryl Hydrocarbon Receptor in Environmentally Induced Skin Aging and Skin Carcinogenesis.


MeSH Terms

  • Animals
  • Environmental Exposure
  • Extracellular Matrix
  • Humans
  • Receptors, Aryl Hydrocarbon
  • Skin Aging
  • Skin Neoplasms

Keywords

  • DNA damage
  • UV radiation
  • extracellular matrix
  • extrinsic skin aging
  • melanoma
  • particulate matter
  • pigmentation
  • polycyclic aromatic hydrocarbons
  • squamous cell carcinoma

AIP[править]

[Aryl hydrocarbon receptor interacting protein (AIP) in human dermis during aging.]


Keywords

  • AIP
  • PCNA
  • aging
  • fibroblasts
  • skin


Sex-Specific Association between Serum Vitamin D Status and Lipid Profiles: A Cross-Sectional Study of a Middle-Aged and Elderly Chinese Population.


Keywords

  • atherogenic index of plasma
  • dyslipidaemia
  • gerontology
  • sex difference
  • vitamin D


The oblique effect: The relationship between profiles of visuospatial preference, cognition, and brain connectomics in older adults.


MeSH Terms

  • Aged
  • Brain
  • Cognition
  • Connectome
  • Diffusion Tensor Imaging
  • Executive Function
  • Female
  • Humans
  • Judgment
  • Male
  • Middle Aged
  • Neuropsychological Tests
  • Pattern Recognition, Visual
  • Spatial Processing

Keywords

  • Aging
  • Executive function
  • Oblique effect
  • Perception
  • Structural connectivity
  • Visuospatial processing

ALAS1[править]

Heterozygous disruption of ALAS1 in mice causes an accelerated age-dependent reduction in free heme, but not total heme, in skeletal muscle and liver.


Keywords

  • 5-Aminolevulinate synthase 1 (ALAS1)
  • 5-Aminolevulinic acid (ALA)
  • Aging
  • Free heme
  • Liver
  • Skeletal muscle

ALB[править]

Effects of Age on Inflammatory Profiles and Nutrition/Energy Metabolism in Domestic Cats.


Keywords

  • M/L ratio
  • SAA
  • aging
  • domestic cats
  • obesity

ALK[править]

Catalog of Lung Cancer Gene Mutations Among Chinese Patients.


Keywords

  • China
  • aging
  • gene mutation
  • lung cancer
  • pathology
  • tobacco smoking

ALKBH8[править]

Loss of epitranscriptomic control of selenocysteine utilization engages senescence and mitochondrial reprogramming .


MeSH Terms

  • AlkB Homolog 8, tRNA Methyltransferase
  • Animals
  • Cells, Cultured
  • Cellular Senescence
  • Epigenesis, Genetic
  • Gene Deletion
  • Gene Expression Profiling
  • Humans
  • Mice
  • Mitochondria
  • Oxygen Consumption
  • Selenocysteine
  • Uncoupling Protein 2

Keywords

  • Epitranscriptome
  • Mitochondria
  • Selenium
  • Senescence
  • Uncoupling protein

ALOX12[править]

Arachidonate 12-lipoxygenase and 12-hydroxyeicosatetraenoic acid contribute to stromal aging-induced progression of pancreatic cancer.


Keywords

  • aging
  • arachidonic acid (AA) (ARA)
  • cancer biology
  • cell proliferation
  • fibroblast
  • pancreatic cancer
  • stromal cell

ALOX5[править]

Functional Characterization of Knock-In Mice Expressing a 12/15-Lipoxygenating Alox5 Mutant Instead of the 5-Lipoxygenating Wild-Type Enzyme.


MeSH Terms

  • Aging
  • Alanine
  • Animals
  • Arachidonate 5-Lipoxygenase
  • Asparagine
  • Body Weight
  • Female
  • Gene Knock-In Techniques
  • Leukotrienes
  • Linoleic Acid
  • Male
  • Mice
  • Mutation
  • PPAR gamma
  • Phenylalanine

Keywords

  • eicosanoids
  • inflammation
  • leukotrienes
  • lipoxygenase
  • resolvins

AMH[править]

Beyond premature ovarian insufficiency: Staging reproductive aging in adolescent and young adult cancer survivors.


Keywords

  • STRAW
  • adolescent and young adult cancer
  • menopausal transition
  • premature ovarian insufficiency
  • reproductive aging


Correlates and Timing of Reproductive Aging Transitions in a Global Cohort of Midlife Women With Human Immunodeficiency Virus: Insights From the REPRIEVE Trial.


Keywords

  • Cardiometabolic Risk
  • HIV
  • Menopause
  • Reproductive Aging
  • Sex
  • Women


Epigenetic clock measuring age acceleration via DNA methylation levels in blood is associated with decreased oocyte yield.


Keywords

  • Aging
  • DNA methylation
  • Epigenetic clock
  • Epigenetics
  • Infertility
  • Methylome
  • Ovarian aging


Modeling Variation in the Reproductive Lifespan of Female Adolescent and Young Adult Cancer Survivors Using AMH.


Keywords

  • AMH
  • adolescent and young adult cancer
  • functional principal components analysis
  • ovarian reserve
  • reproductive lifespan


Improving Prediction of Age at Menopause Using Multiple Anti-Müllerian Hormone Measurements: the Tehran Lipid-Glucose Study.


Keywords

  • Tehran Lipid and Glucose Study (TLGS)
  • anti-müllerian hormone (AMH)
  • menopause
  • reproductive aging


Antimullerian Hormone and Impending Menopause in Late Reproductive Age: The Study of Women's Health Across the Nation.


Keywords

  • aging
  • female reproductive endocrinology
  • gonadotropins
  • inhibin/activin/follistatin/AMH
  • menopause
  • ovaries


Basal characterization and in vitro differentiation of putative stem cells derived from the adult mouse ovary.


MeSH Terms

  • Aging
  • Animals
  • Anti-Mullerian Hormone
  • Antigens, Ly
  • Cell Differentiation
  • Cell Shape
  • Female
  • Lewis X Antigen
  • Membrane Proteins
  • Mice, Inbred C57BL
  • Ovary
  • Stem Cells

Keywords

  • BMP-4
  • Multipotent
  • Ovary
  • Retinoic acid
  • Stem cells


Serum anti-Müllerian hormone concentration and follicle density throughout reproductive life and in different diseases-implications in fertility preservation.


MeSH Terms

  • Adolescent
  • Adult
  • Aging
  • Anti-Mullerian Hormone
  • Child
  • Child, Preschool
  • Female
  • Fertility Preservation
  • Humans
  • Ovarian Follicle
  • Retrospective Studies
  • Young Adult

Keywords

  • anti-Müllerian hormone
  • cancer
  • fertility preservation
  • ovarian reserve
  • ovarian tissue
  • primary follicle
  • primordial follicle


Associations Between Anti-Mullerian Hormone and Cardiometabolic Health in Reproductive Age Women Are Explained by Body Mass Index.


MeSH Terms

  • Adult
  • Anti-Mullerian Hormone
  • Biomarkers
  • Body Mass Index
  • Cardiovascular Diseases
  • Case-Control Studies
  • Cross-Sectional Studies
  • Female
  • Follow-Up Studies
  • Humans
  • Incidence
  • Infertility, Female
  • Polycystic Ovary Syndrome
  • Prognosis
  • United States

Keywords

  • anti-mullerian hormone (AMH)
  • cardiometabolic health
  • cardiovascular risk
  • ovarian aging
  • ovarian reserve markers
  • reproductive aging


Relationships between antral follicle count, blood serum concentration of anti-Müllerian hormone and fertility in mares.


MeSH Terms

  • Aging
  • Animals
  • Anti-Mullerian Hormone
  • Female
  • Fertility
  • Horses
  • Ovarian Follicle
  • Ovulation

Keywords

  • AMH
  • Anzahl Follikel
  • Ovar
  • Pferd
  • Ultraschall
  • compte folliculaire
  • conta dei follicoli
  • ecografia
  • equine
  • equini
  • follicle count
  • ovaia
  • ovaire
  • ovary
  • reproductive status
  • stato riproduttivo
  • ultrasonography
  • ­Reproduktionsstatus
  • échographie
  • équin
  • état reproducteur

AMT[править]

A multi-method comparison of autobiographical memory impairments amongst younger and older adults.


Keywords

  • Depression
  • aging
  • episodic memory
  • overgeneral
  • specificity

ANGPTL2[править]

Circulating angiopoietin-like protein 2 levels and mortality risk in patients receiving maintenance hemodialysis: a prospective cohort study.


MeSH Terms

  • Aged
  • Angiopoietin-like Proteins
  • Biomarkers
  • C-Reactive Protein
  • Disease Progression
  • Female
  • Humans
  • Kidney Diseases
  • Male
  • Middle Aged
  • Prognosis
  • Prospective Studies
  • Renal Dialysis
  • Risk Factors
  • Survival Rate

Keywords

  • aging
  • angiopoietin-like protein (ANGPTL) 2
  • chronic inflammation
  • hemodialysis
  • mortality risk

ANK3[править]

Age-related atrophy of cortical thickness and genetic effect of ANK3 gene in first episode MDD patients.


Keywords

  • ANK3
  • Aging
  • Cortical thickness
  • Major depressive disorder
  • Neuroimage

AOX1[править]

N1-Methylnicotinamide: An Anti-Ovarian Aging Hormetin?


Keywords

  • AMPK
  • MNAM
  • Ovarian Aging
  • ROS

AP2B1[править]

Circular RNA NF1-419 enhances autophagy to ameliorate senile dementia by binding Dynamin-1 and Adaptor protein 2 B1 in AD-like mice.


MeSH Terms

  • Adaptor Protein Complex beta Subunits
  • Aging
  • Alzheimer Disease
  • Animals
  • Astrocytes
  • Autophagy
  • Cellular Senescence
  • Dynamin I
  • Genes, Neurofibromatosis 1
  • Mice
  • RNA, Circular
  • Rats
  • Rats, Sprague-Dawley

Keywords

  • aging
  • astrocyte
  • autophagy
  • biological function
  • circular RNA

APC[править]

Differences between blacks and whites in well-being, beliefs, emotional states, behaviors and survival, 1978-2014.


MeSH Terms

  • Adult
  • African Americans
  • Aged
  • Behavior
  • Cohort Studies
  • Emotions
  • European Continental Ancestry Group
  • Female
  • Hispanic Americans
  • Humans
  • Longevity
  • Male
  • Middle Aged
  • Socioeconomic Factors
  • Survival Analysis
  • United States


Wnt-induced, TRP53-mediated Cell Cycle Arrest of Precursors Underlies Interstitial Cell of Cajal Depletion During Aging.


Keywords

  • Compliance
  • Senescence
  • Stem Cell


Burden of musculoskeletal disorders in Iran during 1990-2017: estimates from the Global Burden of Disease Study 2017.


MeSH Terms

  • Female
  • Global Burden of Disease
  • Global Health
  • Humans
  • Iran
  • Life Expectancy
  • Male
  • Musculoskeletal Diseases
  • Quality-Adjusted Life Years

Keywords

  • Burden
  • DALY
  • Decomposition
  • Global burden of diseases
  • Iran
  • Musculoskeletal diseases


Fall-related mortality trends in older Japanese adults aged ≥65 years: a nationwide observational study.


MeSH Terms

  • Accidental Falls
  • Aged
  • Aged, 80 and over
  • Female
  • Geriatrics
  • Health Policy
  • Health Services Needs and Demand
  • Humans
  • Japan
  • Male
  • Mortality
  • Public Health

Keywords

  • adult intensive & critical care
  • epidemiology
  • geriatric medicine
  • health & safety
  • health policy
  • public health


Stroke Mortality Rates and Trends in Romania, 1994-2017.


MeSH Terms

  • Adult
  • Age Distribution
  • Aged
  • Aged, 80 and over
  • Cause of Death
  • Female
  • Humans
  • Life Expectancy
  • Male
  • Middle Aged
  • Prognosis
  • Registries
  • Risk Assessment
  • Risk Factors
  • Romania
  • Sex Distribution
  • Stroke
  • Time Factors

Keywords

  • Mortality
  • age-standardized mortality rates
  • life expectancy
  • stroke


A new approach to quantifying the EEG during walking: Initial evidence of gait related potentials and their changes with aging and dual tasking.


MeSH Terms

  • Accelerometry
  • Adult
  • Aged
  • Aging
  • Electroencephalography
  • Evoked Potentials
  • Exercise Test
  • Female
  • Gait
  • Humans
  • Male
  • Middle Aged
  • Multitasking Behavior
  • Reaction Time
  • Walking

Keywords

  • Dual task
  • EEG
  • Gait cycle
  • Gait related potentials (GRP)

APOC3[править]

Positional Obstructive Sleep Apnea Syndrome in Elderly Patients.


MeSH Terms

  • Adult
  • Aged
  • Humans
  • Middle Aged
  • Polysomnography
  • Posture
  • Prospective Studies
  • Sleep Apnea, Obstructive
  • Supine Position
  • Young Adult

Keywords

  • aging effects
  • obstructive sleep apnea
  • polysomnography
  • positional sleep apnea

APOE[править]

Polygenic risk score of longevity predicts longer survival across an age-continuum.


Keywords

  • centenarians
  • cognitive health
  • genetics
  • healthy aging
  • longevity


Association Between APOE Alleles and Change of Neuropsychological Tests in the Long Life Family Study.


Keywords

  • APOE
  • cognition
  • longevity
  • longitudinal studies


The APOE gene cluster responds to air pollution factors in mice with coordinated expression of genes that differs by age in humans.


Keywords

  • Alzheimer's disease
  • aging
  • air pollution
  • apolipoprotein E
  • chromosome 19q13


Homozygosity in the [i]APOE[/i] 3 Polymorphism Is Associated With Less Depression and Higher Serum Low-Density Lipoprotein in Chinese Elderly Schizophrenics.


Keywords

  • APOE E3
  • Chinese
  • aging
  • depressive symptom
  • schizophrenia


Effect of apolipoprotein E polymorphism on cognition and brain in the Cambridge Centre for Ageing and Neuroscience cohort.


Keywords

  • Cognition
  • ageing
  • apolipoprotein E
  • brain
  • lifespan


Cardiovascular risk factors and APOE-ε4 status affect memory functioning in aging via changes to temporal stem diffusion.


Keywords

  • APOE
  • BMI
  • RRID:SCR_001398
  • RRID:SCR_002403
  • RRID:SCR_002823
  • RRID:SCR_002865
  • RRID:SCR_007037
  • aging
  • diffusion tensor imaging
  • hypertension
  • memory
  • path modeling


APOE [i]ε[/i]4 and resting-state functional connectivity in racially/ethnically diverse older adults.


Keywords

  • APOE ε4 differences
  • brain aging
  • dementia
  • neuroimaging
  • racial/ethnic differences
  • resting‐state functional connectivity


Predictors of Olfactory Decline in Aging: A Longitudinal Population-Based Study.


Keywords

  • Cognitive aging
  • Epidemiology
  • Olfactory
  • Olfactory impairment


When Culture Influences Genes: Positive Age Beliefs Amplify the Cognitive-Aging Benefit of APOE ε2.


Keywords 

         APOE
  • Age beliefs
  • Cognition
  • Gene
  • Health and Retirement Study
  • Self-perceptions of aging


Age and the association between apolipoprotein E genotype and Alzheimer disease: A cerebrospinal fluid biomarker-based case-control study.


MeSH Terms

  • Adult
  • Aged
  • Aged, 80 and over
  • Aging
  • Alzheimer Disease
  • Apolipoprotein E4
  • Biomarkers
  • Case-Control Studies
  • Cohort Studies
  • Female
  • Genotype
  • Humans
  • Male
  • Middle Aged


Estimating the potential for dementia prevention through modifiable risk factors elimination in the real-world setting: a population-based study.


Keywords

  • Aging
  • Alzheimer’s disease
  • Dementia
  • Dementia prevention
  • Modifiable risk factors
  • Population attributable fraction
  • Public health


Machine learning-based estimation of cognitive performance using regional brain MRI markers: the Northern Manhattan Study.


Keywords

  • Biomarkers
  • Brain aging
  • Cognitive aging
  • Machine learning


Effects of an APOE Promoter Polymorphism on Fronto-Parietal Functional Connectivity During Nondemented Aging.


Keywords

  • APOE promoter
  • aging
  • brain connectome
  • fronto-parietal network
  • working memory


The relationship of parental longevity with the aging brain-results from UK Biobank.


Keywords

  • Aging
  • Brain structure
  • DTI
  • MRI
  • Neuroimaging
  • Parental longevity


Alzheimer's Patient Microglia Exhibit Enhanced Aging and Unique Transcriptional Activation.


Keywords

  • Alzheimer’s disease
  • aging
  • microglia
  • neurodegenerative diseases
  • neuroinflammation
  • transcriptomics


Relationships Between Plasma Lipids Species, Gender, Risk Factors, and Alzheimer's Disease.


Keywords

  • APOEɛ4
  • Aging
  • Alzheimer’s disease
  • gender
  • lipid

species


Effects of sex, age, and apolipoprotein E genotype on hippocampal parenchymal fraction in cognitively normal older adults.


MeSH Terms

  • Age Factors
  • Aged
  • Aged, 80 and over
  • Apolipoproteins E
  • Biomarkers
  • Cognition
  • Databases, Factual
  • Female
  • Genotype
  • Hippocampus
  • Humans
  • Linear Models
  • Male
  • Middle Aged
  • Neuroimaging
  • Organ Size
  • Parenchymal Tissue
  • Reference Values
  • Sex Factors

Keywords

  • Alzheimer’s disease
  • Apolipoprotein E ϵ4
  • Atrophy
  • Brain
  • Healthy aging
  • Hippocampal parenchymal fraction
  • Hippocampal volumetric integrity
  • Hippocampus
  • MRI
  • Mild cognitive impairment
  • Neurodegeneration
  • Sex


Cognitive Health of Nonagenarians in Southern Italy: A Descriptive Analysis from a Cross-Sectional, Home-Based Pilot Study of Exceptional Longevity (Cilento Initiative on Aging Outcomes Or CIAO).


Keywords

  • Cilento Region
  • cognitive health
  • lifestyle
  • longevity


Apolipoprotein E and Health in Older Men: The Concord Health and Ageing in Men Project.


Keywords

  • Aging
  • Alzheimer’s disease
  • Apolipoprotein E
  • Cognition
  • Cognitive frailty
  • Frailty
  • Male


CSF amyloid is a consistent predictor of white matter hyperintensities across the disease course from aging to Alzheimer's disease.


MeSH Terms

  • Aged
  • Aged, 80 and over
  • Aging
  • Alzheimer Disease
  • Amyloid beta-Peptides
  • Biomarkers
  • Cerebrovascular Disorders
  • Cognitive Dysfunction
  • Female
  • Humans
  • Magnetic Resonance Imaging
  • Male
  • Peptide Fragments
  • White Matter
  • tau Proteins

Keywords

  • Alzheimer's disease
  • Amyloid
  • Cerebrospinal fluid
  • Tau
  • Vascular disease
  • White matter hyperintensities


Association of Cardiovascular Risk Factors with Cerebral Perfusion in Whites and African Americans.


Keywords

  • Aging
  • Alzheimer’s disease
  • blood pressure
  • cerebrovascular circulation
  • neuroimaging
  • obesity


Alzheimer's Risk Factors Age, APOE Genotype, and Sex Drive Distinct Molecular Pathways.


MeSH Terms

  • Adaptor Proteins, Signal Transducing
  • Age Factors
  • Aging
  • Alzheimer Disease
  • Animals
  • Apolipoprotein E2
  • Apolipoprotein E3
  • Apolipoprotein E4
  • Apolipoproteins E
  • Brain
  • Female
  • Gene Expression
  • Gene Expression Profiling
  • Gene Regulatory Networks
  • Genotype
  • Humans
  • Male
  • Membrane Glycoproteins
  • Membrane Proteins
  • Metabolome
  • Mice
  • Mice, Transgenic
  • Protective Factors
  • Receptors, Immunologic
  • Risk Factors
  • Serpins
  • Sex Factors
  • Unfolded Protein Response

Keywords

  • APOE
  • Alzheimer’s disease
  • Serpina3
  • age
  • extracellular vesicles
  • inflammation
  • lipid metabolism
  • metabolomics
  • sex
  • transcriptomics


Less agreeable, better preserved? A PET amyloid and MRI study in a community-based cohort.


MeSH Terms

  • Aged
  • Aged, 80 and over
  • Amyloidogenic Proteins
  • Apolipoproteins E
  • Brain
  • Cognition
  • Cohort Studies
  • Female
  • Follow-Up Studies
  • Humans
  • Magnetic Resonance Imaging
  • Male
  • Neuroimaging
  • Organ Size
  • Personality
  • Positron-Emission Tomography

Keywords

  • Amyloid load
  • Cognitive aging
  • Cohort studies
  • Personality
  • Structural MRI


Physical Activity as Moderator of the Association Between APOE and Cognitive Decline in Older Adults: Results from Three Longitudinal Cohort Studies.


Keywords

  • Gene–environment interaction
  • InCHIANTI
  • Longitudinal Aging Study Amsterdam
  • Rotterdam Study


Longitudinal Maintenance of Cognitive Health in Centenarians in the 100-plus Study.


MeSH Terms

  • Aged, 80 and over
  • Aging
  • Apolipoprotein E4
  • Cognition
  • Female
  • Humans
  • Longitudinal Studies
  • Male
  • Mental Status and Dementia Tests
  • Prospective Studies


Interaction of APOE, cerebral blood flow, and cortical thickness in the entorhinal cortex predicts memory decline.


Keywords

  • APOE ε4
  • Aging
  • Cerebral blood flow
  • Cognitive decline
  • Cortical thickness


Determinants of mesial temporal lobe volume loss in older individuals with preserved cognition: a longitudinal PET amyloid study.


MeSH Terms

  • Aged
  • Aged, 80 and over
  • Aging
  • Alleles
  • Amyloidogenic Proteins
  • Apolipoprotein E4
  • Cognitive Reserve
  • Female
  • Follow-Up Studies
  • Genotype
  • Humans
  • Longitudinal Studies
  • Male
  • Neuropsychological Tests
  • Organ Size
  • Positron-Emission Tomography
  • Sex Factors
  • Temporal Lobe

Keywords

  • APOE
  • Amyloid load
  • Cognitive changes
  • Mesial temporal lobe
  • Normal aging
  • Structural MRI


Long-term exposure to ambient air pollution, APOE-ε4 status, and cognitive decline in a cohort of older adults in northern Manhattan.


MeSH Terms

  • Aged
  • Air Pollutants
  • Air Pollution
  • Apolipoprotein E4
  • Apolipoproteins E
  • Cognitive Dysfunction
  • Female
  • Genotype
  • Humans
  • Male
  • Prospective Studies
  • Washington

Keywords

  • APOE-ε4 allele
  • Aging
  • Air pollution
  • Cognitive decline
  • Cognitive risk factors
  • Epidemiology


Evidence in support of chromosomal sex influencing plasma based metabolome vs APOE genotype influencing brain metabolome profile in humanized APOE male and female mice.


MeSH Terms

  • Age of Onset
  • Aging
  • Alzheimer Disease
  • Amyloid beta-Peptides
  • Animals
  • Apolipoprotein E4
  • Apolipoproteins E
  • Brain
  • Disease Models, Animal
  • Female
  • Genotype
  • Humans
  • Magnetic Resonance Imaging
  • Male
  • Metabolome
  • Mice
  • Mice, Transgenic
  • Sex Characteristics
  • Sex Chromosomes


APOE region molecular signatures of Alzheimer's disease across races/ethnicities.


MeSH Terms

  • Alleles
  • Alzheimer Disease
  • Apolipoproteins E
  • Continental Population Groups
  • Haplotypes
  • Heterozygote
  • Homozygote
  • Humans
  • Linkage Disequilibrium
  • Polymorphism, Single Nucleotide
  • Risk Factors

Keywords

  • APOE polymorphism
  • Aging
  • Alzheimer's disease
  • Health span
  • Life span
  • Neurodegenerative disorders


Varying Effects of APOE Alleles on Extreme Longevity in European Ethnicities.


MeSH Terms

  • Aged, 80 and over
  • Alleles
  • Apolipoproteins E
  • Ethnic Groups
  • Europe
  • European Continental Ancestry Group
  • Female
  • Humans
  • Longevity
  • Male

Keywords

  • APOE
  • Bioinformatics
  • Human genetics
  • Longevity


Prospective Evaluation of Cognitive Health and Related Factors in Elderly at Risk for Developing Alzheimer's Dementia: A Longitudinal Cohort Study.


MeSH Terms

  • Aged
  • Aged, 80 and over
  • Alzheimer Disease
  • Anxiety
  • Apolipoprotein E4
  • Cognition
  • Cognitive Dysfunction
  • Cohort Studies
  • Depression
  • Efficiency
  • Female
  • Healthy Volunteers
  • Humans
  • Longitudinal Studies
  • Male
  • Mental Status and Dementia Tests
  • Middle Aged
  • Neuropsychological Tests
  • Prospective Studies
  • Risk Factors
  • Sleep
  • United Kingdom
  • Work

Keywords

  • Alzheimer Disease
  • CHARIOT
  • aging registry
  • cognitive health
  • pre-clinical


Association of Cardiovascular and Alzheimer's Disease Risk Factors with Intracranial Arterial Blood Flow in Whites and African Americans.


MeSH Terms

  • African Americans
  • Aged
  • Alzheimer Disease
  • Biomarkers
  • Blood Flow Velocity
  • Cardiovascular Diseases
  • Cerebrovascular Circulation
  • European Continental Ancestry Group
  • Female
  • Humans
  • Male
  • Middle Aged
  • Risk Factors

Keywords

  • African Americans
  • Alzheimer’s disease
  • Apolipoprotein E4
  • aging
  • cerebrovascular circulation
  • glucose
  • metabolic syndrome
  • neuroimaging
  • risk factors


Is Ongoing Anticholinergic Burden Associated With Greater Cognitive Decline and Dementia Severity in Mild to Moderate Alzheimer's Disease?


Keywords

  • Alzheimers
  • Cognitive aging
  • Drug related
  • Medication


Multicenter Alzheimer's and Parkinson's disease immune biomarker verification study.


MeSH Terms

  • Age Factors
  • Aged
  • Aged, 80 and over
  • Alzheimer Disease
  • Amyloid
  • Biomarkers
  • Cohort Studies
  • Europe
  • Female
  • Humans
  • Inflammation
  • Male
  • Middle Aged
  • Parkinson Disease
  • Sex Factors
  • tau Proteins

Keywords

  • Aging
  • Alzheimer's disease
  • Amyloid
  • Biomarker
  • Cerebrospinal fluid
  • Inflammation
  • Mild cognitive impairment
  • Multicenter
  • Parkinson's disease
  • Tau


Prospective Memory: Age related change is influenced by APOE genotype.


Keywords

  • APOE
  • Alzheimer’s disease
  • aging
  • mid-adulthood
  • prospective memory


Education Moderates the Relation Between APOE ɛ4 and Memory in Nondemented Non-Hispanic Black Older Adults.


MeSH Terms

  • Adult
  • African Americans
  • Aged
  • Aged, 80 and over
  • Aging
  • Alzheimer Disease
  • Apolipoprotein E4
  • Cognitive Reserve
  • Educational Status
  • Executive Function
  • Female
  • Humans
  • Male
  • Memory
  • Memory, Episodic
  • Memory, Short-Term
  • Middle Aged
  • Neuropsychological Tests
  • Sex Characteristics

Keywords

  • APOE
  • African American
  • Alzheimer’s disease
  • cognitive reserve
  • educational attainment
  • episodic memory
  • genetic risk
  • neuropsychological evaluation


Apolipoprotein E ε4 allele effects on longitudinal cognitive trajectories are sex and age dependent.


MeSH Terms

  • Age Factors
  • Aged
  • Alleles
  • Apolipoprotein E4
  • Cognition Disorders
  • European Continental Ancestry Group
  • Executive Function
  • Female
  • Humans
  • Longitudinal Studies
  • Male
  • Memory
  • Neuropsychological Tests
  • Sex Factors

Keywords

  • Aging
  • Alzheimer's disease
  • Apolipoprotein E ε4
  • Cognitive decline
  • Sex


Interactive effect of age and APOE-ε4 allele load on white matter myelin content in cognitively normal middle-aged subjects.


MeSH Terms

  • Age Factors
  • Aged
  • Aging
  • Apolipoprotein E4
  • Female
  • Humans
  • Magnetic Resonance Imaging
  • Male
  • Middle Aged
  • Myelin Sheath
  • White Matter

Keywords

  • Aging
  • Alzheimer
  • Apolipoprotein E
  • Cognitively normal subjects
  • Myelination
  • T1w/T2w ratio
  • White matter integrity


APOE modifies the interaction of entorhinal cerebral blood flow and cortical thickness on memory function in cognitively normal older adults.


MeSH Terms

  • Aged
  • Aged, 80 and over
  • Apolipoproteins E
  • Cerebral Cortex
  • Cerebrovascular Circulation
  • Entorhinal Cortex
  • Female
  • Genotype
  • Humans
  • Linear Models
  • Male
  • Memory
  • Middle Aged

Keywords

  • APOE ε4
  • Aging
  • Alzheimer’s disease
  • Cerebral blood flow
  • Cognitive decline
  • Cortical thickness


When time's arrow doesn't bend: APOE-ε4 influences episodic memory before old age.


MeSH Terms

  • Adult
  • Alleles
  • Alzheimer Disease
  • Apolipoprotein E4
  • Cognition
  • Cognitive Aging
  • Female
  • Genotype
  • Humans
  • Linear Models
  • Male
  • Memory
  • Memory, Episodic
  • Middle Aged
  • Young Adult

Keywords

  • Alzheimer's diseas
  • Apolipoprotein E
  • Cognition
  • Episodic memory
  • Semantic memory


Cognitive-Motor Integration Performance Is Affected by Sex, APOE Status, and Family History of Dementia.


MeSH Terms

  • Aged
  • Apolipoproteins E
  • Cognition
  • Cognitive Dysfunction
  • Cross-Sectional Studies
  • Dementia
  • Female
  • Humans
  • Male
  • Medical History Taking
  • Middle Aged
  • Photic Stimulation
  • Psychomotor Performance
  • Sex Characteristics
  • Surveys and Questionnaires

Keywords

  • Aging
  • alzheimer’s disease
  • apolipoprotein E4
  • dementia risk
  • geriatric

assessment

  • motor skills
  • movement
  • visuomotor integration


Associations among amyloid status, age, and longitudinal regional brain atrophy in cognitively unimpaired older adults.


MeSH Terms

  • Aged
  • Aged, 80 and over
  • Aging
  • Amyloid beta-Peptides
  • Atrophy
  • Brain
  • Cognition
  • Cognitive Dysfunction
  • Databases, Factual
  • Female
  • Humans
  • Longitudinal Studies
  • Male
  • Middle Aged

Keywords

  • Aging
  • Alzheimer's disease
  • Amyloid-β
  • Brain atrophy


Cognitive function and neuropathological outcomes: a forward-looking approach.


MeSH Terms

  • Aged
  • Aged, 80 and over
  • Aging
  • Alzheimer Disease
  • Cognitive Dysfunction
  • Female
  • Humans
  • Male
  • Middle Aged

Keywords

  • Alzheimer’s disease
  • Cognition
  • Multi-state model
  • Neuropathology


APOE gene-dependent BOLD responses to a breath-hold across the adult lifespan.


MeSH Terms

  • Adult
  • Aged
  • Aging
  • Apolipoprotein E3
  • Apolipoprotein E4
  • Apolipoproteins E
  • Breath Holding
  • Cerebrovascular Circulation
  • Cross-Over Studies
  • Double-Blind Method
  • Female
  • Genotype
  • Hemodynamics
  • Humans
  • Longevity
  • Magnetic Resonance Imaging
  • Male
  • Middle Aged
  • Nitrates

Keywords

  • Ageing
  • Alzheimer's disease
  • Apolipoprotein E
  • BOLD fMRI
  • Breath-hold
  • Cerebrovascular reactivity

APP[править]

Pre-symptomatic Caspase-1 inhibitor delays cognitive decline in a mouse model of Alzheimer disease and aging.


MeSH Terms

  • Aging
  • Alzheimer Disease
  • Amyloid beta-Peptides
  • Animals
  • Behavior, Animal
  • Cognitive Dysfunction
  • Cytokines
  • Dipeptides
  • Disease Models, Animal
  • Encephalitis
  • Female
  • Humans
  • Inflammation
  • Male
  • Memory Disorders
  • Mice
  • Mice, Inbred C57BL
  • Mice, Transgenic
  • Serpins
  • Spatial Memory
  • Viral Proteins
  • para-Aminobenzoates


Regorafenib Regulates AD Pathology, Neuroinflammation, and Dendritic Spinogenesis in Cells and a Mouse Model of AD.


Keywords

  • aging
  • amyloid beta
  • dendritic spine
  • neuroinflammation
  • regorafenib
  • tau


An agnostic reevaluation of the amyloid cascade hypothesis of Alzheimer's disease pathogenesis: The role of APP homeostasis.


Keywords

  • aging
  • amyloid hypothesis
  • amyloid precursor protein homeostasis
  • late onset Alzheimer's disease
  • young onset Alzheimer's disease


Transcriptomic profiling of microglia and astrocytes throughout aging.


Keywords

  • Aging
  • Alzheimer’s disease (AD)
  • Astrocyte
  • Microglia
  • RNA-seq


Platelets in Amyloidogenic Mice Are Activated and Invade the Brain.


Keywords

  • Alzheimer’s disease
  • aging
  • astrocytes
  • platelets
  • vascular pathology


CHIP modulates APP-induced autophagy-dependent pathological symptoms in Drosophila.


MeSH Terms

  • Alzheimer Disease
  • Amyloid beta-Protein Precursor
  • Animals
  • Aspartic Acid Endopeptidases
  • Autophagy
  • Brain
  • Cognitive Dysfunction
  • Disease Models, Animal
  • Dopaminergic Neurons
  • Down-Regulation
  • Drosophila
  • Drosophila Proteins
  • Eye
  • Learning Disabilities
  • Locomotion
  • Longevity
  • Nuclear Proteins
  • Presenilins
  • RNA Interference
  • Wings, Animal

Keywords

CHIP

  • APP
  • Alzheimer’s disease
  • Aβ
  • autophagy


Studies on APP metabolism related to age-associated mitochondrial dysfunction in APP/PS1 transgenic mice.


MeSH Terms

  • Adenosine Triphosphate
  • Aging
  • Alzheimer Disease
  • Amyloid beta-Protein Precursor
  • Animals
  • Blood Platelets
  • Disease Models, Animal
  • Hippocampus
  • Mice
  • Mice, Inbred C57BL
  • Mice, Transgenic
  • Mitochondria
  • Presenilin-1

Keywords

  • APP/PS1 mice
  • Amyloid-beta
  • adenosine 5’-triphosphate
  • mitochondria dysfunction
  • platelets


Intermittent Hypoxia-Hyperoxia Training Improves Cognitive Function and Decreases Circulating Biomarkers of Alzheimer's Disease in Patients with Mild Cognitive Impairment: A Pilot Study.


MeSH Terms

  • Aged
  • Alzheimer Disease
  • Biomarkers
  • Case-Control Studies
  • Cognition
  • Cognitive Dysfunction
  • Female
  • Humans
  • Hyperoxia
  • Hypoxia
  • Male
  • Middle Aged
  • Pilot Projects
  • Respiratory Therapy
  • Treatment Outcome

Keywords

  • Alzheimer’s disease
  • adaptation
  • aging
  • amyloid beta
  • biomarker
  • cognitive function
  • hyperoxia
  • intermittent hypoxia
  • platelets


The Implication of Androgens in the Presence of Protein Kinase C to Repair Alzheimer’s Disease-Induced Cognitive Dysfunction


MeSH Terms

  • Adult
  • Aged
  • Aged, 80 and over
  • Aging
  • Alzheimer Disease
  • Amyloid Precursor Protein Secretases
  • Amyloid beta-Peptides
  • Androgens
  • Aspartic Acid Endopeptidases
  • Cognition
  • Cognitive Dysfunction
  • Cyclic AMP Response Element-Binding Protein
  • Female
  • Hippocampus
  • Humans
  • Learning
  • MAP Kinase Signaling System
  • Male
  • Middle Aged
  • Neoplasm Proteins
  • Phosphorylation
  • Protein Kinase C
  • Receptors for Activated C Kinase
  • tau Proteins

Keywords

  • Androgens
  • Cognition
  • Hippocampus
  • Protein kinase C
  • Spatial memory


Modulation of Neural and Muscular Adaptation Processes During Resistance Training by Fish Protein Ingestions in Older Adults.


Keywords

  • Aging
  • Alaska pollack protein
  • Motor unit identification
  • Multichannel surface electromyography
  • Nutritional supplementation


Antipsychotic Polypharmacy in Older Adult Asian Patients With Schizophrenia: Research on Asian Psychotropic Prescription Pattern.


MeSH Terms

  • Aged
  • Aged, 80 and over
  • Aging
  • Antipsychotic Agents
  • Asian Continental Ancestry Group
  • Female
  • Humans
  • Male
  • Middle Aged
  • Polypharmacy
  • Schizophrenia

Keywords

  • Asian
  • antipsychotic polypharmacy
  • older adult patients
  • schizophrenia


A pleiotropic role for exosomes loaded with the amyloid β precursor protein carboxyl-terminal fragments in the brain of Down syndrome patients.


MeSH Terms

  • Amyloid beta-Protein Precursor
  • Brain
  • Down Syndrome
  • Exosomes
  • Humans

Keywords

  • APP
  • APP-CTFs
  • Aging
  • Brain
  • Down syndrome
  • Exosomes
  • Extracellular vesicles

APPL1[править]

Insulin and adipokine signaling and their cross-regulation in postmortem human brain.


MeSH Terms

  • Adipokines
  • Aging
  • Brain
  • Humans
  • Insulin
  • Leptin
  • Postmortem Changes
  • Signal Transduction

Keywords

  • Adipokine
  • Adiponectin receptors
  • Alzheimer's disease–related dementias
  • Leptin receptors
  • Postmortem brain
  • Type 2 diabetes
  • insulin signaling

AQP3[править]

Transbuccal platform for delivery of lipogenic actives to facial skin: Because fat matters.


Keywords

  • adipocytes
  • aging
  • cosmetics
  • face
  • fat pads
  • integument
  • subcutis
  • wrinkles

AR[править]

Mechanisms of Androgen Receptor Agonist- and Antagonist-Mediated Cellular Senescence in Prostate Cancer.


Keywords

  • PKB/Akt
  • Src
  • androgen receptor antagonist
  • antiandrogen
  • bipolar androgen therapy
  • cellular senescence
  • prostate cancer
  • supraphysiological androgen levels


Interleukin-23 Represses the Level of Cell Senescence Induced by the Androgen Receptor Antagonists Enzalutamide and Darolutamide in Castration-Resistant Prostate Cancer Cells.


Keywords

  • Androgen receptor antagonists
  • Cellular senescence
  • Interleukin-23
  • Prostate cancer spheroids


A Landscape of Murine Long Non-Coding RNAs Reveals the Leading Transcriptome Alterations in Adipose Tissue during Aging.


Keywords

  • adipocyte
  • adipose tissue
  • aging
  • lncRNA
  • long non-coding RNA
  • non-coding RNA
  • transcriptome


Senolytic compounds control a distinct fate of androgen receptor agonist- and antagonist-induced cellular senescent LNCaP prostate cancer cells.


Keywords

  • Akt inhibitor
  • Antiandrogen
  • Bcl-2 family inhibitor
  • Bipolar androgen therapy
  • Cellular senescence
  • HSP90 inhibitor
  • Prostate cancer
  • Senolytic compounds


Role of gut microbiota in sex- and diet-dependent metabolic disorders that lead to early mortality of androgen receptor-deficient male mice.


MeSH Terms

  • Adipocytes
  • Adipose Tissue
  • Animals
  • Anti-Bacterial Agents
  • Diet
  • Diet, High-Fat
  • Feces
  • Female
  • Gastrointestinal Microbiome
  • Lipid Metabolism
  • Longevity
  • Male
  • Metabolic Diseases
  • Mice
  • Mice, Inbred C57BL
  • Mice, Knockout
  • Obesity
  • Receptors, Androgen
  • Sex Characteristics

Keywords

  • androgen-insensitive syndrome
  • longevity
  • metabolic syndrome
  • testosterone
  • type 2 diabetes


A jaboticaba extract prevents prostatic damage associated with aging and high-fat diet intake.


MeSH Terms

  • Aging
  • Animals
  • Cell Proliferation
  • Diet, High-Fat
  • Male
  • Mice
  • Myrtaceae
  • Plant Extracts
  • Prostate


Identifying blood-specific age-related DNA methylation markers on the Illumina MethylationEPIC® BeadChip.


MeSH Terms

  • Adolescent
  • Adult
  • Aged
  • Aged, 80 and over
  • Aging
  • Child
  • Child, Preschool
  • Cohort Studies
  • CpG Islands
  • DNA Methylation
  • Forensic Genetics
  • Genetic Markers
  • Humans
  • Infant
  • Infant, Newborn
  • Linear Models
  • Middle Aged
  • Oligonucleotide Array Sequence Analysis
  • Young Adult

Keywords

  • Age
  • CpG sites
  • DNA methylation
  • Forensic age estimation
  • Forensic epigenetics
  • Illumina MethylationEPIC

ARC[править]

The Polymorphism rs2968 of [i]LSS[/i] Gene Confers Susceptibility to Age-Related Cataract.


MeSH Terms

  • Aged
  • Aging
  • Alleles
  • Cataract
  • Female
  • Gene Expression Regulation
  • Genetic Association Studies
  • Genetic Predisposition to Disease
  • Genotype
  • Haplotypes
  • Humans
  • Hydroxymethylglutaryl CoA Reductases
  • Intramolecular Transferases
  • Lens, Crystalline
  • Male
  • Middle Aged
  • Polymorphism, Single Nucleotide

Keywords

  • ARC
  • HMGCR
  • LSS
  • SNPs
  • lanosterol


Decreased Anti-Müllerian hormone and Anti-Müllerian hormone receptor type 2 in hypothalami of old Japanese Black cows.


Keywords

  • Müllerian inhibiting substance
  • female reproductive senescence
  • gonadotropin-releasing hormone neuron
  • preoptic area
  • ruminant


Resveratrol delay the cataract formation against naphthalene-induced experimental cataract in the albino rats.


MeSH Terms

  • Animals
  • Cataract
  • Dose-Response Relationship, Drug
  • Male
  • Naphthalenes
  • Rats
  • Rats, Sprague-Dawley
  • Resveratrol

Keywords

  • age-related cataracts
  • aging
  • oxidative stress
  • resveratrol

AREG[править]

Targeting amphiregulin (AREG) derived from senescent stromal cells diminishes cancer resistance and averts programmed cell death 1 ligand (PD-L1)-mediated immunosuppression.


MeSH Terms

  • Amphiregulin
  • Animals
  • Antineoplastic Agents
  • B7-H1 Antigen
  • Cells, Cultured
  • Cellular Senescence
  • Drug Resistance, Neoplasm
  • Humans
  • Mice
  • Mice, Inbred NOD
  • Mice, SCID
  • Stromal Cells
  • Tumor Microenvironment

Keywords

  • aging
  • amphiregulin
  • cancer resistance
  • clinical biomarker
  • combinational treatment
  • programmed cell death 1 ligand
  • senescence-associated secretory phenotype
  • stroma

ARNT[править]

Loss of ARNT in skeletal muscle limits muscle regeneration in aging.


Keywords

  • aging
  • hypoxia signaling
  • muscle regeneration


[Arylhydrocarbon receptor nuclear translocator (ARNT) in human skin during aging.]


MeSH Terms

  • Adolescent
  • Adult
  • Aged
  • Aged, 80 and over
  • Aging
  • Aryl Hydrocarbon Receptor Nuclear Translocator
  • Child
  • Child, Preschool
  • Dermis
  • Fetus
  • Fibroblasts
  • Humans
  • Infant
  • Infant, Newborn
  • Skin
  • Skin Aging
  • Young Adult

Keywords

  • ARNT
  • PCNA
  • aging
  • fibroblasts
  • skin


The E3 ubiquitin ligase STUB1 attenuates cell senescence by promoting the ubiquitination and degradation of the core circadian regulator BMAL1.


Keywords

  • E3 ubiquitin ligase
  • STIP1 homology and U-box-containing protein 1 (STUB1)
  • brain and muscle ARNT-like 1 (BMAL1, ARNTL, MOP3)
  • cell cycle regulation
  • circadian clock
  • hydrogen peroxide
  • proteasome
  • protein degradation
  • senescence
  • ubiquitylation (ubiquitination)

ASB7[править]

ASB7 Is a Novel Regulator of Cytoskeletal Organization During Oocyte Maturation.


Keywords

  • ASBs
  • maternal aging
  • meiosis
  • oocyte
  • reproduction

ASL[править]

Increased blood-brain barrier permeability to water in the aging brain detected using noninvasive multi-TE ASL MRI.


Keywords

  • aging
  • aquaporin-4
  • arterial spin labeling
  • blood-brain barrier
  • blood-brain interface
  • water permeability


Quantitative Cerebrovascular Reactivity in Normal Aging: Comparison Between Phase-Contrast and Arterial Spin Labeling MRI.


Keywords

  • MRI
  • aging
  • arterial spin labeling
  • cerebrovascular reactivity
  • phase-contrast


Correcting Task fMRI Signals for Variability in Baseline CBF Improves BOLD-Behavior Relationships: A Feasibility Study in an Aging Model.


Keywords

  • BOLD deactivation
  • aging
  • cerebral blood flow
  • domain-general
  • language fMRI
  • semantic fluency
  • sensitization

ASXL1[править]

ASXL1 mutation in clonal hematopoiesis.


MeSH Terms

  • Aged
  • Aging
  • Animals
  • Clonal Evolution
  • Codon, Nonsense
  • Hematologic Neoplasms
  • Hematopoiesis
  • Humans
  • Myeloproliferative Disorders
  • Neoplasm Proteins
  • Repressor Proteins

ATF4[править]

Endoplasmic Reticulum Stress Mediates Vascular Smooth Muscle Cell Calcification via Increased Release of Grp78-Loaded Extracellular Vesicles.


Keywords

  • aging
  • arteries
  • endoplasmic reticulum
  • vascular calcification
  • warfarin

ATF6[править]

Cellular proteostasis decline in human senescence.


Keywords

  • UPR
  • chaperones
  • heat shock response
  • protein homeostasis
  • senescence


Impact of endoplasmic reticulum stress on oocyte aging mechanisms.


Keywords

  • ER stress
  • GRP78
  • PERK
  • eIF2α
  • endoplasmic reticulum
  • mouse oocyte
  • oocyte aging
  • salubrinal


ER stress activates immunosuppressive network: implications for aging and Alzheimer's disease.


Keywords

  • Ageing
  • Immunometabolism
  • Immunosenescence
  • Immunosuppression
  • Inflammaging
  • Neurodegeneration


Towards Age-Related Anti-Inflammatory Therapy: Klotho Suppresses Activation of ER and Golgi Stress Response in Senescent Monocytes.


Keywords

  • ER stress response
  • Golgi apparatus/complex stress response
  • SASP
  • immunosenescence
  • klotho
  • monocytes

ATG3[править]

Estrogen Signaling Induces Mitochondrial Dysfunction-Associated Autophagy and Senescence in Breast Cancer Cells.


Keywords

  • Estrogen
  • MCF-7
  • MDA-MB-231
  • autophagy
  • mitochondria
  • senescence

ATG5[править]

Autophagy and heat-shock response impair stress granule assembly during cellular senescence.


Keywords

  • Ageing
  • Cellular senescence
  • Molecular biology
  • Oxidative stress
  • Stress granules

ATG7[править]

Age-related impairment of autophagy in cervical motor neurons.


Keywords

  • Aging
  • Autophagy
  • Motor neuron
  • Neuromuscular dysfunction
  • Spinal cord


Comprehensive Bioinformatics Identifies Key microRNA Players in ATG7-Deficient Lung Fibroblasts.


Keywords

  • autophagy
  • bioinformatics
  • functional network analysis
  • lung fibrosis
  • miR
  • proteomics
  • senescence


Regulation of autophagy by DNA G-quadruplexes.


Keywords

  • G-quadruplex
  • aging
  • astrocytes
  • autophagy
  • neurodegeneration
  • neurons


ATG7 is essential for secretion of iron from ameloblasts and normal growth of murine incisors during aging.


Keywords

  • ATG7
  • Aging
  • ameloblast
  • autophagy
  • epithelium
  • ferritin
  • hyperplasia
  • iron
  • secretion
  • tooth


Enhancing Autophagy Diminishes Aberrant Ca Homeostasis and Arrhythmogenesis in Aging Rabbit Hearts.


Keywords

  • aging
  • autophagy
  • calcium
  • cardiac physiology
  • ryanodine receptor

ATM[править]

SATMF Suppresses the Premature Senescence Phenotype of the ATM Loss-of-Function Mutant and Improves Its Fertility in [i]Arabidopsis[/i].


Keywords

  • ATM
  • DNA damage
  • SATMF
  • fertility
  • leaf senescence


ATM mediated-p53 signaling pathway forms a novel axis for senescence control.


Keywords

  • ATM inhibition
  • Metabolic reprogrammer
  • Mitochondria
  • P53
  • Senescence alleviation


Non-canonical ATM/MRN activities temporally define the senescence secretory program.


Keywords

  • DNA damage response
  • MRN complex
  • NF-κB
  • chromatin
  • senescence secretome


ATM is a key driver of NF-κB-dependent DNA-damage-induced senescence, stem cell dysfunction and aging.


Keywords

  • ATM
  • DNA damage response
  • NF-κB
  • aging
  • cellular senescence


ATM suppresses leaf senescence triggered by DNA double-strand break through epigenetic control of senescence-associated genes in Arabidopsis.


Keywords

Arabidopsis thaliana

  • ATM
  • DNA repair
  • double-strand breaks
  • histone methylation
  • leaf senescence


Glioblastoma Cells Do Not Affect Axitinib-Dependent Senescence of HUVECs in a Transwell Coculture Model.


MeSH Terms

  • Ataxia Telangiectasia Mutated Proteins
  • Axitinib
  • Cell Line, Tumor
  • Cellular Senescence
  • Coculture Techniques
  • Gene Expression Profiling
  • Glioblastoma
  • Human Umbilical Vein Endothelial Cells
  • Humans
  • Phosphorylation

Keywords

  • Axitinib
  • endothelial cells
  • glioblastoma
  • senescence


Declining BRCA-Mediated DNA Repair in Sperm Aging and its Prevention by Sphingosine-1-Phosphate.


Keywords

  • Aging
  • DNA fragmentation
  • Gene expression
  • Sperm


BRCA-related ATM-mediated DNA double-strand break repair and ovarian aging.


MeSH Terms

  • Aging
  • Animals
  • Ataxia Telangiectasia
  • BRCA1 Protein
  • BRCA2 Protein
  • DNA Breaks, Double-Stranded
  • DNA Repair
  • Female
  • Fertility
  • Fertility Preservation
  • Humans
  • Mice
  • Oocytes
  • Ovarian Follicle
  • Ovarian Reserve
  • Ovary

Keywords 

         BRCA
       

         BRCA1/2
  • DNA repair
  • anti-Mullerian hormone
  • chemotherapy
  • mutations
  • oocyte
  • ovarian aging
  • ovarian reserve
  • ovarian response


ATM Deficiency Accelerates DNA Damage, Telomere Erosion, and Premature T Cell Aging in HIV-Infected Individuals on Antiretroviral Therapy.


MeSH Terms

  • Anti-Retroviral Agents
  • Ataxia Telangiectasia Mutated Proteins
  • Cellular Senescence
  • DNA Damage
  • HIV Infections
  • Humans
  • T-Lymphocytes
  • Telomere

Keywords

  • ATM
  • DNA damage repair
  • HIV
  • T cell homeostasis
  • apoptosis
  • immune aging


SMG1 heterozygosity exacerbates haematopoietic cancer development in Atm null mice by increasing persistent DNA damage and oxidative stress.


MeSH Terms

  • Animals
  • Ataxia Telangiectasia Mutated Proteins
  • Carcinogenesis
  • Cells, Cultured
  • DNA Damage
  • Embryo, Mammalian
  • Fibroblasts
  • Gamma Rays
  • Hematologic Neoplasms
  • Heterozygote
  • Kaplan-Meier Estimate
  • Longevity
  • Lymphoma
  • Mice, Inbred C57BL
  • Mice, Knockout
  • Oxidative Stress
  • Protein-Serine-Threonine Kinases

Keywords

  • DNA damage
  • cancer
  • inflammation
  • lymphoma
  • oxidative stress


LncRNA RP11-670E13.6, interacted with hnRNPH, delays cellular senescence by sponging microRNA-663a in UVB damaged dermal fibroblasts.


MeSH Terms

  • Cell Proliferation
  • Cellular Senescence
  • Fibroblasts
  • Heterogeneous-Nuclear Ribonucleoprotein Group F-H
  • Humans
  • MicroRNAs
  • RNA, Long Noncoding
  • Skin
  • Skin Aging
  • Ultraviolet Rays

Keywords

  • cellular senescence
  • dermal fibroblast
  • lncRNA
  • microRNA
  • ultraviolet B


Tel1/ATM Signaling to the Checkpoint Contributes to Replicative Senescence in the Absence of Telomerase.


MeSH Terms

  • Amino Acid Substitution
  • Ataxia Telangiectasia Mutated Proteins
  • Cell Cycle Checkpoints
  • Cell Division
  • Cellular Senescence
  • DNA Damage
  • DNA Replication
  • DNA, Single-Stranded
  • DNA-Binding Proteins
  • Intracellular Signaling Peptides and Proteins
  • Mutant Proteins
  • Protein-Serine-Threonine Kinases
  • Saccharomyces cerevisiae
  • Saccharomyces cerevisiae Proteins
  • Telomerase
  • Telomere
  • Telomere Shortening

Keywords

  • Tel1
  • checkpoint
  • replicative senescence
  • telomere

ATP7A[править]

Adipocyte-specific disruption of ATPase copper transporting α in mice accelerates lipoatrophy.


MeSH Terms

  • 3T3-L1 Cells
  • Adipocytes
  • Adipose Tissue, White
  • Aging
  • Animals
  • Body Weight
  • Copper
  • Copper-Transporting ATPases
  • Diet, High-Fat
  • Energy Metabolism
  • Insulin Resistance
  • Lipid Metabolism
  • Lipodystrophy
  • Lipolysis
  • Mice
  • Mice, Knockout

Keywords

  • ATP7A
  • Adipose tissues
  • Copper
  • Insulin resistance
  • Lipoatrophy

ATR[править]

Bloodstain age estimation through infrared spectroscopy and Chemometric models.


Keywords

  • Aging
  • Bloodstains
  • Chemometric
  • Forensic chemistry
  • MLR
  • PLSR


Artificial Intelligence and fourier-transform infrared spectroscopy for evaluating water-mediated degradation of lubricant oils.


Keywords

  • ANN
  • Artificial neural networks
  • FTIR
  • LDA
  • Linear discriminant analysis
  • Lubricant oil aging


Senescence Induction by Combined Ionizing Radiation and DNA Damage Response Inhibitors in Head and Neck Squamous Cell Carcinoma Cells.


Keywords

  • ATM
  • ATR
  • DNA damage response inhibitor
  • DNAPK
  • HNSCC
  • homologous recombination
  • ionizing radiation
  • kinase inhibitor
  • radiosensitivity
  • senescence


Kinetics of thermal degradation and lifetime study of poly(vinylidene fluoride) (PVDF) subjected to bioethanol fuel accelerated aging.


Keywords

  • Activation energy
  • Aging
  • Bioethanol fuel
  • Kinetics analysis
  • Lifetime prediction
  • Materials chemistry
  • Materials science
  • Poly(vinylidene fluoride)


Supraphysiological protection from replication stress does not extend mammalian lifespan.


Keywords

  • DNA damage
  • aging
  • cancer
  • mouse models
  • replication stress


Assessing the Retest Reliability of Prefrontal EEG Markers of Brain Rhythm Slowing in the Eyes-Closed Resting State.


Keywords

  • EEG
  • EEG slowing
  • brain aging
  • dominant frequency
  • prefrontal


Effects of Hydrogen Peroxide and Sodium Hypochlorite Aging on Properties and Performance of Polyethersulfone Ultrafiltration Membrane.


MeSH Terms

  • Humic Substances
  • Hydrogen Peroxide
  • Hydrophobic and Hydrophilic Interactions
  • Membranes, Artificial
  • Polymers
  • Sodium Hypochlorite
  • Sulfones
  • Ultrafiltration

Keywords

  • chemical cleaning
  • hydrogen peroxide (H2O2)
  • membrane aging
  • polyethersulfone (PES) ultrafiltration (UF) membrane
  • sodium hypochlorite (NaClO)


NF-κB signaling in skin aging.


MeSH Terms

  • Animals
  • Cellular Senescence
  • Humans
  • NF-kappa B
  • Phenotype
  • Signal Transduction
  • Skin Aging
  • Skin Neoplasms

Keywords

  • NF-κB
  • Senescence-associated secretory phenotype
  • Skin aging


Development of a w/o emulsion using ionic liquid strategy for transdermal delivery of anti - aging component α - lipoic acid: Mechanism of different ionic liquids on skin retention and efficacy evaluation.


MeSH Terms

  • Administration, Cutaneous
  • Animals
  • Emulsions
  • Hydroxyproline
  • Ionic Liquids
  • Male
  • Rats, Wistar
  • Skin
  • Skin Absorption
  • Skin Aging
  • Thioctic Acid
  • Ultraviolet Rays

Keywords

  • Anti – aging efficacy
  • Ionic liquids
  • Skin retention
  • Solubility
  • Α – lipoic acid


Effect of Nitrogen-Doped Graphene Oxide on the Aging Behavior of Nitrile-Butadiene Rubber.


Keywords

  • aging resistance
  • graphene oxide
  • nitrile-butadiene rubber
  • nitrogen-doped

AVP[править]

Plasma oxytocin and vasopressin levels in young and older men and women: Functional relationships with attachment and cognition.


MeSH Terms

  • Adolescent
  • Adult
  • Age Factors
  • Aged
  • Aged, 80 and over
  • Aging
  • Anxiety
  • Avoidance Learning
  • Cognition
  • Cohort Studies
  • Female
  • Humans
  • Male
  • Middle Aged
  • Object Attachment
  • Oxytocin
  • Sex Factors
  • Vasopressins
  • Young Adult

Keywords

  • Age
  • Attachment anxiety
  • Oxytocin
  • Processing speed
  • Sex
  • Vasopressin

B4GALT1[править]

Expression of β-1,4-galactosyltransferases during Aging in Caenorhabditis elegans.


Keywords

  • Biomarker
  • Glycosylation
  • Lifespan regulation
  • bre-4
  • sqv-3

BACE1[править]

Electric Stimulation of Neurogenesis Improves Behavioral Recovery After Focal Ischemia in Aged Rats.


Keywords

  • aging
  • behavior
  • electrical stimulation
  • neurogenesis
  • rats
  • stroke


Disruption of synaptic expression pattern and age-related DNA oxidation in a neuronal model of lead-induced toxicity.


Keywords

  • Aging mice
  • Brain-derived neurotrophic factor precursor
  • Latent expression pattern
  • Lead
  • Pubertal exposure
  • Synaptic deficits
  • Tau phosphorylation

BAD[править]

I imidazoline receptor modulation protects aged SAMP8 mice against cognitive decline by suppressing the calcineurin pathway.


Keywords

  • Aging
  • Alzheimer’s disease
  • Behavior
  • I2 imidazoline receptors
  • NFAT
  • Neuroinflammation
  • Neuroprotection

BAK1[править]

Developmental Attenuation of Neuronal Apoptosis by Neural-Specific Splicing of Bak1 Microexon.


MeSH Terms

  • Animals
  • Apoptosis
  • Brain
  • Cell Line, Tumor
  • Cells, Cultured
  • Female
  • Heterogeneous-Nuclear Ribonucleoproteins
  • Male
  • Mice
  • Mice, Inbred C57BL
  • Mutation
  • Neural Stem Cells
  • Neurogenesis
  • Nonsense Mediated mRNA Decay
  • Polypyrimidine Tract-Binding Protein
  • RNA Splicing
  • bcl-2 Homologous Antagonist-Killer Protein

Keywords

  • AS-NMD
  • BAK
  • BCL2 family proteins
  • NMD
  • PTB
  • PTBP
  • PTBP2
  • UPF2
  • alternative splicing
  • cell death
  • neural development
  • neurogenesis
  • neuronal lifespan

BANF1[править]

An additional case of Néstor-Guillermo progeria syndrome diagnosed in early childhood.


Keywords

  • BANF1
  • Néstor-Guillermo progeria syndrome
  • premature aging
  • progeria
  • whole exome sequencing

BATF[править]

LncRNA-ES3 inhibition by Bhlhe40 is involved in high glucose-induced calcification/senescence of vascular smooth muscle cells.


Keywords

  • Bhlhe40
  • VSMC calcification/senescence
  • diabetes
  • lncRNA-ES3
  • microRNA
  • vascular aging

BAX[править]

Clearance of therapy-induced senescent tumor cells by the senolytic ABT-263 via interference with BCL-X -BAX interaction.


Keywords

  • ABT-263
  • BCL-XL
  • chemotherapy
  • radiation
  • senescence
  • senolytic


CREB Signaling Mediates Dose-Dependent Radiation Response in the Murine Hippocampus Two Years after Total Body Exposure.


Keywords

  • CREB signaling
  • aging
  • brain
  • hippocampus
  • ionizing radiation
  • label-free proteomics

BAZ2B[править]

Two conserved epigenetic regulators prevent healthy ageing.


MeSH Terms

  • Aging
  • Animals
  • Caenorhabditis elegans
  • Caenorhabditis elegans Proteins
  • Cognition
  • Cognitive Dysfunction
  • Epigenesis, Genetic
  • Healthy Aging
  • Histone-Lysine N-Methyltransferase
  • Histones
  • Humans
  • Longevity
  • Lysine
  • Male
  • Memory
  • Methylation
  • Mice
  • Mitochondria
  • Neurons
  • Proteins
  • RNA Interference
  • Spatial Learning
  • Transcription Factors, General

BCL6[править]

Ecto-NTPDase CD39 is a negative checkpoint that inhibits follicular helper cell generation.


Keywords

  • Adaptive immunity
  • Aging
  • Cellular senescence
  • T cells
  • Vaccines

BCR[править]

The presence of CLL-associated stereotypic B cell receptors in the normal BCR repertoire from healthy individuals increases with age.


Keywords

  • Aging
  • B-lymphocyte
  • BCR repertoire
  • CLL
  • Stereotypic BCR

BDNF[править]

Influence of [i]BDNF[/i] Genetic Polymorphisms in the Pathophysiology of Aging-related Diseases.


Keywords

  • Aging
  • BDNF gene
  • aging-related diseases
  • polymorphism


Moderators of the Impact of (Poly)Phenols Interventions on Psychomotor Functions and BDNF: Insights from Subgroup Analysis and Meta-Regression.


Keywords

  • aging
  • antioxidant
  • brain functions
  • brain plasticity
  • cognition
  • psychomotor functions


Astroglia-Derived BDNF and MSK-1 Mediate Experience- and Diet-Dependent Synaptic Plasticity.


Keywords

  • AMPA receptors
  • Arc/Arg3.1
  • GABA receptors
  • TrkB receptors
  • aging
  • calcium signalling
  • dendritic spines
  • diet
  • enriched environment
  • glia-neuron interactions
  • ion conductance microscopy
  • synaptic scaling
  • synaptic strength


BDNF reverses aging-related microglial activation.


Keywords

  • Aging
  • BDNF
  • CREB
  • Microglial activation
  • NF-кB
  • TrkB


High Supervised Resistance Training in Elderly Women: The Role of Supervision Ratio.


Keywords

  • Aging
  • exercise
  • functional capacity
  • muscle strength


Metformin regulates astrocyte reactivity in Parkinson's disease and normal aging.


Keywords

  • Aging
  • Dorsal striatum
  • Metformin
  • Parkinson's disease
  • Reactive astrocyte


Aging-Induced Brain-Derived Neurotrophic Factor in Adipocyte Progenitors Contributes to Adipose Tissue Dysfunction.


Keywords

  • BDNF
  • adipocyte progenitors
  • adipose tissue
  • aging
  • sympathetic innervation


The Role of BDNF on Aging-Modulation Markers.


Keywords

  • BBB
  • astrocytes
  • brain aging
  • in vivo model
  • low dose BDNF


Spermidine and spermine delay brain aging by inducing autophagy in SAMP8 mice.


Keywords

  • aging
  • autophagy
  • mitochondrial dysfunction
  • polyamine


Microglia senescence occurs in both substantia nigra and ventral tegmental area.


Keywords

  • Parkinson's disease
  • aging-dependent neurodegeneration
  • dopamine neurons
  • microglia complexity
  • stereological analyses
  • tyrosine hydroxylase; microglia senescence


Towards an understanding of the physical activity-BDNF-cognition triumvirate: A review of associations and dosage.


MeSH Terms

  • Aging
  • Brain-Derived Neurotrophic Factor
  • Cognition
  • Exercise
  • Healthy Aging
  • Humans

Keywords

  • Ageing
  • BDNF
  • Brain
  • Physical activity


Impact of BDNF and sex on maintaining intact memory function in early midlife.


MeSH Terms

  • Brain
  • Brain-Derived Neurotrophic Factor
  • Cognition
  • Female
  • Humans
  • Magnetic Resonance Imaging
  • Male
  • Memory
  • Memory, Short-Term
  • Menopause
  • Middle Aged
  • Neuroprotective Agents
  • Neuropsychological Tests
  • Reproduction
  • Sex Characteristics

Keywords

  • Aging
  • BDNF
  • Hormones
  • Memory
  • Menopause
  • Sex differences


Testosterone replacement causes dose-dependent improvements in spatial memory among aged male rats.


Keywords

  • Aging
  • BDNF
  • Object location memory
  • Radial arm maze
  • Spatial memory
  • Testosterone


The effects of aerobic exercise intensity on memory in older adults.


Keywords

  • BDNF
  • activité physique
  • aging
  • cognition
  • entraînement par intervalles de haute intensité
  • executive functions
  • exercice
  • exercise
  • fonctions exécutives
  • high-intensity interval training
  • memory
  • mémoire
  • physical activity
  • vieillissement


Protective effects of vitamin D on neurophysiologic alterations in brain aging: role of brain-derived neurotrophic factor (BDNF).


Keywords

  • BDNF
  • Brain aging
  • neurophysiologic alterations
  • neuroprotection
  • vitamin D supplementation


Differential Effects of Physical Exercise, Cognitive Training, and Mindfulness Practice on Serum BDNF Levels in Healthy Older Adults: A Randomized Controlled Intervention Study.


MeSH Terms

  • Aged
  • Brain-Derived Neurotrophic Factor
  • Cognition
  • Correlation of Data
  • Exercise
  • Female
  • Healthy Aging
  • Healthy Lifestyle
  • Humans
  • Learning
  • Male
  • Mindfulness
  • Neuropsychological Tests
  • Outcome Assessment, Health Care

Keywords

  • Aging
  • brain-derived neurotrophic factor
  • cognitive training
  • mindfulness
  • physical exercise


Dietary Supplementation with Fish Oil or Conjugated Linoleic Acid Relieves Depression Markers in Mice by Modulation of the Nrf2 Pathway.


MeSH Terms

  • Aging
  • Animals
  • Antidepressive Agents
  • Autoimmunity
  • Biomarkers
  • Brain
  • Brain-Derived Neurotrophic Factor
  • Depression
  • Dietary Supplements
  • Docosahexaenoic Acids
  • Fatty Acid Elongases
  • Fatty Acids
  • Fish Oils
  • Inflammation
  • Linoleic Acids, Conjugated
  • Liver
  • Male
  • Mice, Inbred MRL lpr
  • NF-E2-Related Factor 2
  • Oxidative Stress
  • Stearoyl-CoA Desaturase
  • Tumor Necrosis Factor-alpha

Keywords

  • brain derived neurotrophic factor
  • brain fatty acid profile
  • conjugated linoleic acid
  • depression
  • fish oil
  • nuclear erythroid related factor-2

BGN[править]

Alterations of local functional connectivity in lifespan: A resting-state fMRI study.


Keywords

  • four-dimensional spatial-temporal consistency of local neural activity
  • lifespan
  • local functional connectivity
  • local functional connectivity density
  • resting-state fMRI

BHLHE40[править]

Thyroid hormone induces cellular senescence in prostate cancer cells through induction of DEC1.


MeSH Terms

  • Basic Helix-Loop-Helix Transcription Factors
  • Cell Line, Tumor
  • Cell Proliferation
  • Cellular Senescence
  • Cyclin-Dependent Kinase Inhibitor p15
  • Homeodomain Proteins
  • Humans
  • Male
  • Prostatic Neoplasms
  • Thyroid Hormones

Keywords

  • BHLHE40
  • Cellular senescence
  • DEC1
  • Prostate cancer
  • Thyroid hormone

BLM[править]

[Olmesartan inhibits age-associated migration and invasion of human aortic vascular smooth muscle cells by upregulating miR-3133 axis].


MeSH Terms

  • Cell Movement
  • Cell Proliferation
  • Cells, Cultured
  • Humans
  • Imidazoles
  • Matrix Metalloproteinase 2
  • MicroRNAs
  • Muscle, Smooth, Vascular
  • Myocytes, Smooth Muscle
  • Tetrazoles

Keywords

  • aging
  • invasion
  • microRNA
  • migration
  • olmesartan
  • vascular smooth muscle cells

BMI1[править]

Senescence Induced by BMI1 Inhibition Is a Therapeutic Vulnerability in H3K27M-Mutant DIPG.


Keywords

  • BH3 mimetics
  • BMI1
  • DIPG
  • H3K27M mutant
  • H3WT
  • PTC 028
  • RNAi screen
  • SASP
  • senescence

BMP2[править]

Interleukin-1β-Induced Senescence Promotes Osteoblastic Transition of Vascular Smooth Muscle Cells.


MeSH Terms

  • Adult
  • Aged
  • Aged, 80 and over
  • Female
  • Humans
  • Interleukin-1beta
  • Male
  • Middle Aged
  • Muscle, Smooth, Vascular
  • Osteoblasts

Keywords

  • Interleukin-1β
  • Osteoblastic transition
  • Senescence
  • Vascular calcification

BMP4[править]

Direct reprogramming of human smooth muscle and vascular endothelial cells reveals defects associated with aging and Hutchinson-Gilford progeria syndrome.


Keywords

  • aging
  • direct reprogramming
  • endothelial cell
  • human
  • hutchinson-gilford progeria syndrome
  • medicine
  • mouse
  • smooth muscle cell
  • vascular barrier

BMP7[править]

Downregulation of miR-542-3p promotes osteogenic transition of vascular smooth muscle cells in the aging rat by targeting BMP7.


MeSH Terms

  • Aging
  • Animals
  • Base Sequence
  • Bone Morphogenetic Protein 7
  • Down-Regulation
  • Glycerophosphates
  • MicroRNAs
  • Models, Biological
  • Muscle, Smooth, Vascular
  • Myocytes, Smooth Muscle
  • Osteogenesis
  • Rats

Keywords

  • Aging
  • Mir-542-3p
  • Osteogenic differentiation
  • Vascular smooth muscle cells

BOC[править]

Protein Requirements of Elderly Chinese Adults Are Higher than Current Recommendations.


MeSH Terms

  • Aged
  • Aging
  • Amino Acids
  • Body Weight
  • China
  • Dietary Proteins
  • Energy Intake
  • Energy Metabolism
  • Female
  • Humans
  • Male
  • Nutritional Requirements
  • Oxidation-Reduction
  • Phenylalanine
  • Recommended Dietary Allowances
  • Tyrosine

Keywords

  • indicator amino acid oxidation
  • older adults
  • phenylalanine oxidation
  • protein requirement
  • stable isotope

BPI[править]

High TARC plasma levels confer protection to long living individuals by inducing M2 profile.


Keywords

  • FACS
  • Longevity
  • M2 macrophages
  • Plasma profile
  • TARC


Circulating BPIFB4 Levels Associate With and Influence the Abundance of Reparative Monocytes and Macrophages in Long Living Individuals.


Keywords

  • FACS
  • M2 macrophages
  • immunity
  • longevity
  • patrolling-monocytes
  • plasma

BPIFB4[править]

New Insights for BPIFB4 in Cardiovascular Therapy.


Keywords

  • BPIFB4
  • aging
  • cardiovascular disease


LAV-BPIFB4 associates with reduced frailty in humans and its transfer prevents frailty progression in old mice.


MeSH Terms

  • Aged
  • Aged, 80 and over
  • Aging
  • Animals
  • Female
  • Frailty
  • Gene Expression Regulation
  • Genotype
  • Humans
  • Longevity
  • Male
  • Mice
  • Mice, Inbred C57BL
  • Mice, Transgenic
  • Phosphoproteins
  • Specific Pathogen-Free Organisms

Keywords

  • BPIFB4
  • aging
  • frailty
  • longevity-associated variant-lav
  • survival

BRAF[править]

Conditional reprograming culture conditions facilitate growth of lower grade glioma models.


Keywords

  • BRAFV600E
  • Conditional reprogramming
  • NF1
  • Senescence
  • low grade glioma


Active notch protects MAPK activated melanoma cell lines from MEK inhibitor cobimetinib.


Keywords

  • Cobimetinib (PubChem CID: 16222096)
  • MEK
  • Nirogacestat (PubChem CID:46224413)
  • Notch
  • Senescence
  • Uveal melanoma


Mitochondrial metabolic reprograming via BRAF inhibition ameliorates senescence.


MeSH Terms

  • Cell Proliferation
  • Cells, Cultured
  • Cellular Reprogramming
  • Cellular Senescence
  • Drug Evaluation, Preclinical
  • Humans
  • Mitochondria
  • Proto-Oncogene Proteins B-raf

Keywords

  • BRAF
  • Metabolic reprogramming
  • Mitochondrial function
  • SB590885
  • Senescence

BRD2[править]

Brd2 haploinsufficiency extends lifespan and healthspan in C57B6/J mice.


MeSH Terms

  • Animals
  • Female
  • Fertility
  • Grooming
  • Haploinsufficiency
  • Kidney
  • Longevity
  • Male
  • Mice
  • Mice, Inbred C57BL
  • Transcription Factors

BRD4[править]

Inhibition of BRD4 triggers cellular senescence through suppressing aurora kinases in oesophageal cancer cells.


Keywords

  • BRD4
  • aurora kinase
  • cellular senescence
  • oesophageal cancer


BRD4 contributes to LPS-induced macrophage senescence and promotes progression of atherosclerosis-associated lipid uptake.


Keywords

  • BRD4
  • gene expression
  • inflammation
  • macrophage
  • senescence


BET Proteins Are Required for Transcriptional Activation of the Senescent Islet Cell Secretome in Type 1 Diabetes.


MeSH Terms

  • Animals
  • Cell Cycle Proteins
  • Cellular Senescence
  • Diabetes Mellitus, Type 1
  • Female
  • Humans
  • Insulin-Secreting Cells
  • Islets of Langerhans
  • Mice
  • Mice, Inbred NOD
  • Paracrine Communication
  • Protein Binding
  • Transcription Factors
  • Transcriptional Activation

Keywords

  • BET proteins
  • beta cells
  • senescence and SASP
  • type 1 diabetes

BTK[править]

Amelioration of age-related brain function decline by Bruton's tyrosine kinase inhibition.


Keywords

  • BTK
  • cellular senescence
  • healthspan
  • p53
  • progeria

C2[править]

[Effects of resistance training on mitochondrial function in skeletal muscle of aging rats].


MeSH Terms

  • Aging
  • Animals
  • Male
  • Membrane Potential, Mitochondrial
  • Mitochondria, Muscle
  • Muscle, Skeletal
  • Physical Conditioning, Animal
  • Rats
  • Rats, Sprague-Dawley
  • Resistance Training

Keywords

  • fusion protein 2
  • mitochondria
  • quadriceps
  • rats
  • resistance training


Structural and functional characterization of Solanum lycopersicum phosphatidylinositol 3-kinase C2 domain.


MeSH Terms

  • Animals
  • C2 Domains
  • Lycopersicon esculentum
  • Phosphatidylinositol 3-Kinase
  • Plants, Genetically Modified
  • Protein Binding
  • Tobacco

Keywords

  • C2 domain
  • Membrane binding
  • Phosphatidylinositol 3-kinase
  • Senescence

C3[править]

Inverse association between periumbilical fat and longevity mediated by complement C3 and cardiac structure.


Keywords

  • abdominal obesity
  • cardiac structure
  • complement C3
  • longevity
  • periumbilical fat


Complement C3 deficiency ameliorates aging related changes in the kidney.


MeSH Terms

  • Aging
  • Animals
  • Complement C3
  • Inflammation
  • Kidney
  • Kidney Diseases
  • Male
  • Mice
  • Mice, Inbred C57BL
  • Mice, Knockout

Keywords

  • Complement component 3
  • Kidney disorder
  • Senescence


Reduced sialylation triggers homeostatic synapse and neuronal loss in middle-aged mice.


MeSH Terms

  • Aging
  • Animals
  • Brain
  • Homeostasis
  • Immunity, Innate
  • Mice, Transgenic
  • Neurons
  • Racemases and Epimerases
  • Sialic Acid Binding Immunoglobulin-like Lectins
  • Sialic Acids
  • Synapses

Keywords

  • Aging
  • GNE
  • Glycocalyx
  • Microglia
  • Neurodegeneration
  • Neuroinflammation
  • Sialic acid


[Comparative analysis of experimental data about the effects of various polyphenols on lifespan and aging.]


MeSH Terms

  • Animals
  • Antioxidants
  • Female
  • Longevity
  • Male
  • Mice
  • Mice, Inbred BALB C
  • Polyphenols
  • Survival Analysis

Keywords

  • BP-C3
  • Gompertz model
  • SkQ1
  • aging
  • herbal extracts
  • lifespan
  • metformin
  • polyphenols
  • resveratrol
  • tocopherol

C5[править]

The C5-75 Program: Meeting the Need for Efficient, Pragmatic Frailty Screening and Management in Primary Care.


Keywords

  • aging
  • case-finding
  • co-morbid conditions
  • comorbidité
  • dépistage
  • fragilité
  • frailty
  • primary care
  • recherche de cas
  • screening
  • soins de première ligne
  • vieillissement


Can a relatively large spinal cord for the dural sac influence severity of paralysis in elderly patients with cervical spinal cord injury caused by minor trauma?


MeSH Terms

  • Aged
  • Aged, 80 and over
  • Cervical Vertebrae
  • Female
  • Geriatrics
  • Humans
  • Japan
  • Magnetic Resonance Imaging
  • Male
  • Paralysis
  • Severity of Illness Index
  • Spinal Canal
  • Spinal Cord
  • Spinal Cord Injuries
  • Tomography, X-Ray Computed
  • Wounds and Injuries

C6[править]

Evolution of the Aroma of Treixadura Wines during Bottle Aging.


Keywords

  • bottle aging
  • flavor profile
  • sensory evaluation
  • volatile composition
  • white wine


D-galactose induces senescence of glioblastoma cells through YAP-CDK6 pathway.


Keywords

  • CDK6
  • D-galatose
  • YAP
  • cellular senescence
  • glioblastoma

C7[править]

The Vertebral Artery Convergence to the Cervical Spine in Elders.


MeSH Terms

  • Aged
  • Aged, 80 and over
  • Aging
  • Cervical Vertebrae
  • Computed Tomography Angiography
  • Cross-Sectional Studies
  • Female
  • Humans
  • Male
  • Middle Aged
  • Retrospective Studies
  • Vertebral Artery

Keywords

  • angiography
  • computed tomography
  • osteoarthritis
  • spine
  • vertebral artery
  • aging

C9[править]

C9orf72 in myeloid cells suppresses STING-induced inflammation.


MeSH Terms

  • Aging
  • Amyotrophic Lateral Sclerosis
  • Animals
  • C9orf72 Protein
  • Dendritic Cells
  • Encephalomyelitis, Autoimmune, Experimental
  • Female
  • Humans
  • Inflammation
  • Interferon Type I
  • Membrane Proteins
  • Mice
  • Myeloid Cells
  • Neoplasms
  • T-Lymphocytes


Glycine-alanine dipeptide repeats spread rapidly in a repeat length- and age-dependent manner in the fly brain.


MeSH Terms

  • Aging
  • Alanine
  • Animals
  • Animals, Genetically Modified
  • Brain
  • C9orf72 Protein
  • DNA Repeat Expansion
  • Dipeptides
  • Drosophila
  • Female
  • Glycine

Keywords

  • Ageing
  • C9orf72
  • Dipeptide repeat proteins
  • Drosophila
  • PolyGA
  • Repeat size
  • Spread


Human iPSC-derived astrocytes from ALS patients with mutated C9ORF72 show increased oxidative stress and neurotoxicity.


MeSH Terms

  • Amyotrophic Lateral Sclerosis
  • Animals
  • Astrocytes
  • Biomarkers
  • C9orf72 Protein
  • Cells, Cultured
  • Cellular Reprogramming
  • Cellular Senescence
  • Cerebral Cortex
  • Disease Models, Animal
  • Gene Expression Profiling
  • Glutamic Acid
  • Humans
  • Induced Pluripotent Stem Cells
  • Mice
  • Motor Neurons
  • Mutation
  • Oxidative Stress
  • Proteomics
  • Reactive Oxygen Species

Keywords

  • Amyotrophic lateral sclerosis
  • Astrocytes
  • Neurotoxicity
  • Oxidative stress
  • Senescence
  • iPSC

C9orf72[править]

Carriership of two copies of C9orf72 hexanucleotide repeat intermediate-length alleles is a risk factor for ALS in the Finnish population.


Keywords

  • ALS
  • Aging
  • C9orf72
  • Case-control analysis
  • Intermediate repeats

CA1[править]

The relation between tau pathology and granulovacuolar degeneration of neurons.


Keywords

  • AT8
  • Aging
  • CA1
  • Casein kinase 1δ
  • Congo red
  • Dorsal raphe nucleus
  • Locus coeruleus
  • Neurodegeneration
  • Tau pathology


Memory and dendritic spines loss, and dynamic dendritic spines changes are age-dependent in the rat.


Keywords

  • Aging
  • Hippocampus
  • Locomotor activity
  • Memory and learning
  • Prefrontal cortex
  • Pyramidal neurons
  • dendritic spines


Deregulated expression of a longevity gene, Klotho, in the C9orf72 deletion mice with impaired synaptic plasticity and adult hippocampal neurogenesis.


Keywords

  • Amyotrophic lateral sclerosis (ALS)
  • C9ORF72
  • Dentate gyrus, adult neurogenesis
  • Frontotemporal dementia (FTD)
  • Klotho
  • Long-term depression (LTD)
  • Long-term potentiation (LTP)
  • Longevity


COX5A Plays a Vital Role in Memory Impairment Associated With Brain Aging [i]via[/i] the BDNF/ERK1/2 Signaling Pathway.


Keywords

  • BDNF
  • COX5A
  • ERK1/2
  • brain senescence
  • memory impairment
  • mitochondria


Changes of fat-mass and obesity-associated protein expression in the hippocampus in animal models of high-fat diet-induced obesity and D-galactose-induced aging.


Keywords

  • Aging
  • Fto
  • Hippocampus
  • Mice
  • Obesity


Phenylbutyrate ameliorates prefrontal cortex, hippocampus, and nucleus accumbens neural atrophy as well as synaptophysin and GFAP stress in aging mice.


Keywords

  • aging
  • dendrites
  • hippocampus
  • memory and learning
  • nucleus accumbens
  • prefrontal cortex
  • sodium phenylbutyrate


Heterogeneity in brain distribution of activated microglia and astrocytes in a rat ischemic model of Alzheimer's disease after 2 years of survival.


Keywords

  • Alzheimer’s disease
  • aging
  • brain ischemia
  • glia
  • neuroinflammation


Hippocampal Subregion Transcriptomic Profiles Reflect Strategy Selection during Cognitive Aging.


MeSH Terms

  • Animals
  • Cognitive Aging
  • Dentate Gyrus
  • Hippocampus
  • Maze Learning
  • Rats
  • Rats, Inbred F344
  • Spatial Memory
  • Transcriptome

Keywords

  • aging
  • hippocampus
  • pattern separation
  • reference memory
  • spatial discrimination
  • transcription


Associations between pattern separation and hippocampal subfield structure and function vary along the lifespan: A 7 T imaging study.


MeSH Terms

  • Adult
  • Age Factors
  • Aged
  • Brain Mapping
  • Female
  • Hippocampus
  • Humans
  • Longevity
  • Magnetic Resonance Imaging
  • Male
  • Middle Aged
  • Young Adult


Laminarin Pretreatment Provides Neuroprotection against Forebrain Ischemia/Reperfusion Injury by Reducing Oxidative Stress and Neuroinflammation in Aged Gerbils.


Keywords

  • aging
  • laminarin
  • neuroinflammation
  • neuroprotection
  • oxidative stress
  • transient cerebral ischemia


Age-dependent Alteration in Mitochondrial Dynamics and Autophagy in Hippocampal Neuron of Cannabinoid CB1 Receptor-deficient Mice.


Keywords

  • Aging
  • CB1 receptor
  • Hippocampus
  • Mitochondria
  • Mitophagy


Functional Connectivity of Hippocampal CA3 Predicts Neurocognitive Aging via CA1-Frontal Circuit.


Keywords

  • aging
  • functional connectivity
  • hippocampus
  • spatial memory


Integration of qRT-PCR and Immunohistochemical Techniques for mRNA Expression and Localization of m1AChR in the Brain of Aging Rat.


Keywords

  • Acetylcholine
  • Aging
  • Brain
  • Immunohistochemistry
  • m1AChR
  • qRT-PCR


Role of Eclipta prostrata extract in improving spatial learning and memory deficits in D-galactose-induced aging in rats.


MeSH Terms

  • Aging
  • Animals
  • Behavior, Animal
  • CA1 Region, Hippocampal
  • Catalase
  • Dopamine
  • Eclipta
  • Galactose
  • Gene Expression Regulation, Enzymologic
  • Glutathione Peroxidase
  • Glutathione Reductase
  • Male
  • Memory Disorders
  • Nitric Oxide
  • Nitric Oxide Synthase Type II
  • Norepinephrine
  • Plant Extracts
  • RNA, Messenger
  • Rats
  • Rats, Sprague-Dawley
  • Serotonin
  • Spatial Learning
  • Superoxide Dismutase

Keywords

  • Antioxidants
  • Eclipta
  • Galactose
  • Memory disorders
  • Spatial learning


Differential annualized rates of hippocampal subfields atrophy in aging and future Alzheimer's clinical syndrome.


MeSH Terms

  • Aged
  • Aging
  • Alzheimer Disease
  • Atrophy
  • Cohort Studies
  • Cross-Sectional Studies
  • Dentate Gyrus
  • Female
  • Hippocampus
  • Humans
  • Magnetic Resonance Imaging
  • Male
  • Neuropsychological Tests
  • Risk

Keywords

  • Aging
  • Alzheimer's disease
  • Hippocampal subfields
  • MRI


Rectification of radiotherapy-induced cognitive impairments in aged mice by reconstituted Sca-1 stem cells from young donors.


MeSH Terms

  • Animals
  • Behavior, Animal
  • Cognitive Dysfunction
  • Dendritic Spines
  • Hematopoietic Stem Cell Transplantation
  • Hippocampus
  • Humans
  • Long-Term Potentiation
  • Maze Learning
  • Memory
  • Mice
  • Neurons
  • Radiotherapy
  • Recovery of Function
  • Spinocerebellar Ataxias
  • Treatment Outcome

Keywords

  • Aging
  • Bone marrow stem cells
  • Learning and memory
  • Microglia
  • Radiotherapy


Increasing neurogenesis refines hippocampal activity rejuvenating navigational learning strategies and contextual memory throughout life.


MeSH Terms

  • Aging
  • Animals
  • Cyclin D1
  • Cyclin-Dependent Kinase 4
  • Female
  • Hippocampus
  • Learning
  • Memory
  • Memory Consolidation
  • Mice
  • Mice, Inbred C57BL
  • Neural Stem Cells
  • Neurogenesis


Memory Performance Correlates of Hippocampal Subfield Volume in Mild Cognitive Impairment Subtype.


Keywords

  • aging
  • hippocampus
  • memory
  • mild cognitive impairment
  • neuroimaging
  • subfields


Spermidine protects from age-related synaptic alterations at hippocampal mossy fiber-CA3 synapses.


MeSH Terms

  • Aging
  • Animals
  • CA3 Region, Hippocampal
  • Long-Term Potentiation
  • Mice
  • Mossy Fibers, Hippocampal
  • Spermidine
  • Synaptic Transmission
  • Synaptic Vesicles


Methylene blue inhibits Caspase-6 activity, and reverses Caspase-6-induced cognitive impairment and neuroinflammation in aged mice.


MeSH Terms

  • Aging
  • Animals
  • Caspase 6
  • Caspase Inhibitors
  • Cognitive Dysfunction
  • Female
  • Humans
  • Inflammation
  • Male
  • Methylene Blue
  • Mice
  • Mice, Inbred C57BL
  • Mice, Knockout
  • Mice, Transgenic

Keywords

  • Alzheimer disease
  • Axonal degeneration
  • Caspase-6
  • Caspase-6 inhibitor
  • Hippocampal CA1
  • Hippocampal fibres
  • Methylene blue
  • Synaptic plasticity
  • White matter


Long-term Memory Upscales Volume of Postsynaptic Densities in the Process that Requires Autophosphorylation of αCaMKII.


Keywords

  • CA1 area
  • CaMKII
  • IntelliCages
  • aging
  • dendritic spines
  • memory
  • postsynaptic density


PACAP27 mitigates an age-dependent hippocampal vulnerability to PGJ2-induced spatial learning deficits and neuroinflammation in mice.


Keywords

  • CA1
  • CA3
  • Fluoro-Jade C
  • aging
  • microglia
  • radial arm maze


Inhibition of oxidative stress by testosterone improves synaptic plasticity in senescence accelerated mice.


MeSH Terms

  • Aging
  • Animals
  • Male
  • Mice
  • Neuronal Plasticity
  • Oxidative Stress
  • Random Allocation
  • Receptors, N-Methyl-D-Aspartate
  • Testosterone

Keywords

  • Alzheimer’s disease
  • N-methyl-D-aspartate receptor-1
  • Senescence accelerated mouse
  • Testosterone
  • oxidative stress


Restored presynaptic synaptophysin and cholinergic inputs contribute to the protective effects of physical running on spatial memory in aged mice.


MeSH Terms

  • Aging
  • Animals
  • Cholinergic Neurons
  • Hippocampus
  • Mice
  • Mice, Inbred C57BL
  • Physical Conditioning, Animal
  • Presynaptic Terminals
  • Spatial Memory
  • Synaptophysin

Keywords

  • Aging
  • Cholinergic cells
  • Hippocampus
  • Memory
  • Physical training
  • Presynaptic terminals
  • Synaptophysin


Senescent neurophysiology: Ca signaling from the membrane to the nucleus.


MeSH Terms

  • Aging
  • Animals
  • CA1 Region, Hippocampal
  • Calcium Signaling
  • Cell Nucleus
  • Epigenesis, Genetic
  • Excitatory Postsynaptic Potentials
  • Humans
  • Membrane Potentials
  • Neuronal Plasticity
  • Pyramidal Cells
  • Receptors, N-Methyl-D-Aspartate

Keywords

  • Afterhyperpolarization
  • Aging
  • Epigenetics
  • Hippocampus
  • N-methyl-D-aspartate receptor
  • Synaptic plasticity
  • Transcription

CA2[править]

Maintaining Aging Hippocampal Function with Safe and Feasible Shaking Exercise in SAMP10 Mice.


Keywords

  • Aging
  • Behavior analysis
  • Hippocampus
  • Shaking exercise
  • Spatial cognition


One-year Follow-up Study of Hippocampal Subfield Atrophy in Alzheimer's Disease and Normal Aging.


MeSH Terms

  • Aged
  • Aged, 80 and over
  • Aging
  • Alzheimer Disease
  • Atrophy
  • Case-Control Studies
  • Cognitive Dysfunction
  • Disease Progression
  • Female
  • Follow-Up Studies
  • Hippocampus
  • Humans
  • Magnetic Resonance Imaging
  • Male
  • Neuroimaging

Keywords

  • Alzheimer's disease
  • biomarker
  • hippocampal
  • mild cognitive impairment
  • neurodegenerative diseases
  • normal aging
  • radial distance
  • subfield atrophy


Maturation of PNN and ErbB4 Signaling in Area CA2 during Adolescence Underlies the Emergence of PV Interneuron Plasticity and Social Memory.


MeSH Terms

  • Aging
  • Animals
  • Animals, Newborn
  • CA2 Region, Hippocampal
  • Interneurons
  • Long-Term Synaptic Depression
  • Male
  • Memory
  • Mice
  • Mice, Inbred C57BL
  • Neural Inhibition
  • Neuregulin-1
  • Neuronal Plasticity
  • Parvalbumins
  • Receptor, ErbB-4
  • Receptors, Opioid, delta
  • Signal Transduction
  • Social Behavior
  • Synapses
  • gamma-Aminobutyric Acid

Keywords

  • ErbB4
  • adolescence
  • area CA2
  • delta opioid receptors
  • hippocampus
  • long-term depression
  • neuregulin 1
  • parvalbumin interneuron
  • perineuronal net
  • social memory

CA3[править]

Features of Postnatal Hippocampal Development in a Rat Model of Sporadic Alzheimer's Disease.


Keywords

  • Alzheimer’s disease
  • OXYS rats
  • aging
  • hippocampal mossy fibers
  • hippocampus
  • neurogenesis
  • postnatal development


Age-Related Changes in Synaptic Plasticity Associated with Mossy Fiber Terminal Integration during Adult Neurogenesis.


Keywords

  • aging
  • conditional transgenic
  • giant synapse
  • stratum lucidum
  • synaptogenesis


Metabotropic Glutamate Receptors at the Aged Mossy Fiber - CA3 Synapse of the Hippocampus.


Keywords

  • aging
  • hippocampal area CA3
  • mGluRs
  • mossy fibers
  • synaptic transmission

CACNA1S[править]

Increased calcium channel in the lamina propria of aging rat.


MeSH Terms

  • Aging
  • Animals
  • Calcium Channel Blockers
  • Calcium Channels
  • Cell Line
  • Fibroblasts
  • Gene Expression Regulation
  • Humans
  • Larynx
  • Male
  • Mucous Membrane
  • Rats
  • Rats, Sprague-Dawley
  • Verapamil

Keywords

  • aging
  • calcium channel
  • extracellular matrix
  • vocal fold

CAD[править]

Serum soluble Klotho is inversely related to coronary artery calcification assessed by intravascular ultrasound in patients with stable coronary artery disease.


Keywords

  • Aging
  • Coronary artery calcification
  • Intravascular ultrasound
  • Klotho


Shear bond strengths of aged and non-aged CAD/CAM materials after different surface treatments.


Keywords

  • Bond strength
  • Computer-aided design and computer-aided manufacturing (CAD/CAM)
  • Laser
  • Repair
  • Surface treatment
  • Thermal aging


Prediction of Early Postoperative Major Cardiac Events and In-Hospital Mortality in Elderly Hip Fracture Patients: The Role of Different Types of Preoperative Cardiac Abnormalities on Echocardiography Report.


MeSH Terms

  • Aged
  • Aortic Valve Stenosis
  • Cardiovascular Diseases
  • Comorbidity
  • Echocardiography
  • Female
  • Fracture Fixation
  • Hip Fractures
  • Hospital Mortality
  • Humans
  • Male
  • Postoperative Complications
  • Prognosis
  • Risk Factors

Keywords

  • aging
  • echocardiographic abnormality
  • hip fracture surgery
  • mortality
  • postoperative cardiac complications


[Polymorbidity in elderly patients needing myocardial revascularization (a review article).]


MeSH Terms

  • Aged
  • Cognitive Dysfunction
  • Coronary Artery Disease
  • Humans
  • Myocardial Revascularization
  • Quality of Life
  • Risk

Keywords

  • aging
  • elderly
  • ischemic heart disease
  • myocardial revascularization
  • polymorbidity


Fracture force of CAD/CAM resin composite crowns after in vitro aging.


MeSH Terms

  • Ceramics
  • Composite Resins
  • Computer-Aided Design
  • Crowns
  • Dental Porcelain
  • Dental Restoration Failure
  • Dental Stress Analysis
  • Humans
  • Materials Testing

Keywords

  • Aging
  • CAD/CAM
  • CAD/CAM bloc
  • Dental material
  • Fit
  • Preparation
  • Resin composite
  • Resin-based material
  • Storage
  • TCML


Clinical performance of chairside monolithic lithium disilicate glass-ceramic CAD-CAM crowns.


MeSH Terms

  • Ceramics
  • Computer-Aided Design
  • Crowns
  • Dental Porcelain
  • Dental Prosthesis Design
  • Humans
  • Materials Testing

Keywords

  • CAD-CAM
  • chairside
  • dental crowns
  • lithium disilicate
  • longevity
  • survival


Acute resveratrol supplementation in coronary artery disease: towards patient stratification.


MeSH Terms

  • Aged
  • Biomarkers
  • Brachial Artery
  • Cardiac Rehabilitation
  • Coronary Artery Bypass
  • Coronary Artery Disease
  • Cross-Over Studies
  • Exercise Therapy
  • Female
  • Humans
  • Kinetics
  • Male
  • Middle Aged
  • Oxygen
  • Oxygen Consumption
  • Percutaneous Coronary Intervention
  • Resveratrol
  • Single-Blind Method
  • Treatment Outcome
  • Vasodilation

Keywords

  • Antioxidant
  • aging
  • endothelial dysfunction
  • oxygen uptake

CARM1[править]

CARM1 regulates senescence during airway epithelial cell injury in COPD pathogenesis.


MeSH Terms

  • Aged
  • Animals
  • Apoptosis
  • Cell Differentiation
  • Cell Proliferation
  • Cellular Senescence
  • Epithelial Cells
  • Female
  • Humans
  • Male
  • Mice, Inbred C57BL
  • Mice, Knockout
  • Middle Aged
  • Naphthalenes
  • Protein-Arginine N-Methyltransferases
  • Pulmonary Disease, Chronic Obstructive
  • Respiratory Mucosa
  • Wound Healing

Keywords

  • CARM1
  • COPD
  • airway epithelium
  • senescence

CASP3[править]

Does cartilage ERα overexpression correlate with osteoarthritic chondrosenescence? Indications from [i]Labisia pumila[/i] OA mitigation.


MeSH Terms

  • Aging
  • Animals
  • Bone Development
  • Cartilage
  • Chondrocytes
  • Diclofenac
  • Disease Models, Animal
  • Estrogen Receptor alpha
  • Flavonoids
  • Gallic Acid
  • Gene Expression Regulation
  • Humans
  • Iodoacetates
  • Matrix Metalloproteinase 13
  • Metabolism
  • Osteoarthritis
  • Ovariectomy
  • Plant Extracts
  • Primulaceae
  • Rats

CAT[править]

Training improves the handling of inhaler devices and reduces the severity of symptoms in geriatric patients suffering from chronic-obstructive pulmonary disease.


Keywords

  • Chronic-obstructive pulmonary disease - Inhaler devices
  • Compliance
  • Geriatrics


7-chloro-4-(phenylselanyl) quinoline co-treatment prevent oxidative stress in diabetic-like phenotype induced by hyperglycidic diet in Drosophila melanogaster.


Keywords

  • 4-PSQ
  • 7-chloro-4-(phenylselanyl) quinolone
  • Antioxidant effect
  • Diabetic-like phenotype
  • Hyperglycidic diet
  • Longevity
  • Oxidative stress


Aging influences in the blood-brain barrier permeability and cerebral oxidative stress in sepsis.


Keywords

  • Aging
  • Blood-brain barrier
  • Brain
  • Oxidative stress
  • Sepsis


2 -Deoxy - d-glucose at chronic low dose acts as a caloric restriction mimetic through a mitohormetic induction of ROS in the brain of accelerated senescence model of rat.


Keywords

  • 2-Deoxy- d-glucose
  • Aging
  • Brain
  • CRM
  • Mitohormosis
  • ROS


Ceftriaxone improves senile neurocognition damages induced by D-galactose in mice.


Keywords

  • Aging
  • Ceftriaxone
  • D-galactose
  • Mice
  • Oxidative stress


Ginsenoside Rg1 protects against d-galactose induced fatty liver disease in a mouse model via FOXO1 transcriptional factor.


MeSH Terms

  • Animals
  • Antioxidants
  • Cellular Senescence
  • Disease Models, Animal
  • Fatty Liver
  • Forkhead Box Protein O1
  • Galactose
  • Ginsenosides
  • Lipid Peroxidation
  • Male
  • Medicine, Chinese Traditional
  • Mice
  • Mice, Inbred C57BL
  • Oxidative Stress
  • Protective Agents
  • Transcription Factors

Keywords

  • D-galactose
  • FOXO1
  • Non-alcoholic fatty liver disease
  • Rg1
  • Senescence


Effects of long-term intermittent versus chronic calorie restriction on oxidative stress in a mouse cancer model.


MeSH Terms

  • Aging
  • Animals
  • Antioxidants
  • Caloric Restriction
  • Catalase
  • Erythrocytes
  • Female
  • Glutathione
  • Lipid Peroxidation
  • Malondialdehyde
  • Mammary Neoplasms, Experimental
  • Mice, Inbred C57BL
  • Oxidative Stress
  • Superoxide Dismutase

Keywords

  • MMTV-TGF-α mice
  • breast cancer
  • energy restriction
  • intermittent calorie restriction
  • mammary tumor
  • oxidative stress


The Toxicity of Nonaged and Aged Coated Silver Nanoparticles to Freshwater Alga Raphidocelis subcapitata.


MeSH Terms

  • Aquatic Organisms
  • Chlorophyta
  • Fresh Water
  • Hydrodynamics
  • Lipid Peroxidation
  • Metal Nanoparticles
  • Particle Size
  • Reactive Oxygen Species
  • Silver
  • Static Electricity
  • Toxicity Tests

Keywords

  • Aquatic toxicology
  • Ecotoxicology
  • Environmental fate
  • Heavy metals
  • Nanoparticle aging
  • Nanotoxicology

CBS[править]

Permanent cystathionine-β-Synthase gene knockdown promotes inflammation and oxidative stress in immortalized human adipose-derived mesenchymal stem cells, enhancing their adipogenic capacity.


Keywords

  • Cellular senescence
  • Cystathionine β-synthase
  • Human adipose-derived mesenchymal stem cells
  • Inflammation
  • Oxidative stress and adipogenesis


Cardiovascular phenotype of mice lacking 3-mercaptopyruvate sulfurtransferase.


MeSH Terms

  • Animals
  • Antioxidants
  • Cardiovascular System
  • Cystathionine beta-Synthase
  • Cystathionine gamma-Lyase
  • Gene Expression Regulation, Enzymologic
  • Hydrogen Sulfide
  • Male
  • Mice, Inbred C57BL
  • Mice, Knockout
  • Myocardial Reperfusion Injury
  • Myocytes, Cardiac
  • Nitric Oxide
  • Phenotype
  • Reactive Oxygen Species
  • Sulfurtransferases
  • Vasodilation

Keywords

  • 3-mercaptopyruvate transferase (3-MST)
  • Aging
  • Blood pressure
  • Myocardial infarction
  • Nitric Oxide (NO)
  • Reactive Oxygen Species (ROS)

CBX3[править]

Biological functions of chromobox (CBX) proteins in stem cell self-renewal, lineage-commitment, cancer and development.


Keywords

  • Aging
  • Bone
  • CBX1
  • CBX2
  • CBX3
  • CBX4
  • CBX5
  • CBX6
  • CBX7
  • CBX8
  • Cancer
  • Chromatin
  • Development
  • Epigenetics
  • H3K27me3
  • H3K9me3
  • Lineage-commitment
  • Osteoblast
  • Senescence
  • Stem cell

CCK[править]

Senolytic agent Quercetin ameliorates intervertebral disc degeneration via the Nrf2/NF-κB axis.


Keywords

  • Intervertebral disc degeneration
  • NF-κB pathway
  • Nrf2
  • Quercetin
  • Senescence


Astragalus improve aging bone marrow mesenchymal stem cells (BMSCs) vitality and osteogenesis through VD-FGF23-Klotho axis.


Keywords

  • Astragalus
  • BMSCs
  • VD-FGF23-Klotho axis
  • aging
  • osteogenesis differentiation


Effects of Age on Acute Appetite-Related Responses to Whey-Protein Drinks, Including Energy Intake, Gastric Emptying, Blood Glucose, and Plasma Gut Hormone Concentrations-A Randomized Controlled Trial.


Keywords

  • aging
  • appetite
  • energy intake
  • gastric emptying
  • glucose
  • gut hormones
  • whey protein


Lactose induced redox-dependent senescence and activated Nrf2 pathway.


Keywords

  • Lactose
  • Nrf2
  • ROS
  • cellular senescence
  • oxidative stress


Quercetin Suppresses the Progression of Atherosclerosis by Regulating MST1-Mediated Autophagy in ox-LDL-Induced RAW264.7 Macrophage Foam Cells.


MeSH Terms

  • Adenine
  • Animals
  • Atherosclerosis
  • Autophagy
  • Cell Survival
  • Cellular Senescence
  • Cyclin-Dependent Kinase Inhibitor p16
  • Cyclin-Dependent Kinase Inhibitor p21
  • Disease Progression
  • Foam Cells
  • Hepatocyte Growth Factor
  • Lipid Metabolism
  • Lipoproteins, LDL
  • Mice
  • Proto-Oncogene Proteins
  • Quercetin
  • RAW 264.7 Cells
  • Sirolimus
  • Up-Regulation

Keywords

  • RAW264.7
  • atherosclerosis
  • autophagy
  • quercetin
  • senescence


LncRNA AW112010 Promotes Mitochondrial Biogenesis and Hair Cell Survival: Implications for Age-Related Hearing Loss.


MeSH Terms

  • Adenosine Triphosphate
  • Aging
  • Animals
  • Cell Survival
  • DNA-Binding Proteins
  • Gene Silencing
  • Hair Cells, Auditory
  • Hearing Loss
  • Mice
  • Mitochondria
  • Organelle Biogenesis
  • RNA, Long Noncoding
  • Resveratrol
  • Signal Transduction
  • Transcription Factors


Effects of age on feeding response: Focus on the rostral C1 neuron and its glucoregulatory proteins.


Keywords

  • Aging
  • Catecholaminergic neurons
  • Feeding response
  • Glucoprivation
  • Rostral ventrolateral medulla


Ser-Tyr and Asn-Ala, vasorelaxing dipeptides found by comprehensive screening, reduce blood pressure via different age-dependent mechanisms.


MeSH Terms

  • Aging
  • Amino Acid Sequence
  • Animals
  • Antihypertensive Agents
  • Blood Pressure
  • Cholecystokinin
  • Dipeptides
  • Drug Evaluation, Preclinical
  • Hypertension
  • Male
  • Mesenteric Arteries
  • Nitric Oxide
  • Peptide Library
  • Proglumide
  • Rats
  • Rats, Inbred SHR
  • Receptors, Cholecystokinin
  • Vasodilation
  • Vasodilator Agents

Keywords

  • aging
  • dipeptide library
  • nitric oxide
  • structure-activity relationship
  • vasorelaxation


Fisetin, via CKIP-1/REGγ, limits oxidized LDL-induced lipid accumulation and senescence in RAW264.7 macrophage-derived foam cells.


MeSH Terms

  • Animals
  • Autoantigens
  • Carrier Proteins
  • Cellular Senescence
  • Flavonoids
  • Foam Cells
  • Lipid Metabolism
  • Lipoproteins, LDL
  • Mice
  • Proteasome Endopeptidase Complex
  • RAW 264.7 Cells
  • Signal Transduction

Keywords

  • CKIP-1/REGγ signaling
  • Fisetin
  • Lipid accumulation
  • RAW264.7
  • Senescence

CCL11[править]

CCL-11 or Eotaxin-1: An Immune Marker for Ageing and Accelerated Ageing in Neuro-Psychiatric Disorders.


Keywords

  • Alzheimer’s disease
  • CCL-11
  • aging
  • behaviour
  • biomarkers
  • brain
  • cytokines
  • eotaxin
  • prevention
  • schizophrenia
  • stroke

CCL17[править]

Aging and chronic high-fat feeding negatively affects kidney size, function, and gene expression in CTRP1-deficient mice.


Keywords

  • aging
  • heart
  • kidney
  • metabolism
  • obesity

CCL19[править]

Age-Related Gliosis Promotes Central Nervous System Lymphoma through CCL19-Mediated Tumor Cell Retention.


MeSH Terms

  • Adolescent
  • Adult
  • Aged
  • Aging
  • Animals
  • Astrocytes
  • Blood-Brain Barrier
  • Cell Line, Tumor
  • Central Nervous System Neoplasms
  • Chemokine CCL19
  • Chemokine CXCL12
  • Disease Models, Animal
  • Female
  • Gliosis
  • Humans
  • Intravital Microscopy
  • Lymphoma
  • Male
  • Mice
  • Mice, Transgenic
  • Microscopy, Fluorescence, Multiphoton
  • Middle Aged
  • NF-kappa B
  • Receptors, CCR7
  • Time-Lapse Imaging
  • Young Adult

Keywords

  • CCL19
  • CNSL
  • CXCL12
  • DLBCL
  • PCNSL
  • SCNSL
  • gliosis
  • lymphoma
  • metastasis
  • neuroinflammation

CCL2[править]

β1 Integrin regulates adult lung alveolar epithelial cell inflammation.


MeSH Terms

  • Aging
  • Alveolar Epithelial Cells
  • Animals
  • Cell Adhesion
  • Chemokine CCL2
  • Chemokines
  • Disease Models, Animal
  • Epithelium
  • Integrin beta1
  • Lung
  • Macrophages
  • Mice
  • Mice, Inbred C57BL
  • Mice, Knockout
  • Pneumonia
  • Pulmonary Disease, Chronic Obstructive
  • Receptors, CCR2

Keywords

  • COPD
  • Inflammation
  • Integrins
  • Macrophages
  • Pulmonology

CCL20[править]

p53 and p53-related mediators PAI-1 and IGFBP-3 are downregulated in peripheral blood mononuclear cells of HIV-patients exposed to non-nucleoside reverse transcriptase inhibitors.


Keywords

  • Aging
  • Antiretroviral drugs
  • HIV
  • Inflammation
  • NNRTI
  • Senescence
  • p53

CCL28[править]

Age-related chemokine alterations affect IgA secretion and gut immunity in female mice.


Keywords

  • Aging
  • CCL25
  • CCL28
  • Gut immunity
  • IgA

CCN1[править]

Sodium tanshinone IIA sulfonate restrains fibrogenesis through induction of senescence in mice with induced deep endometriosis.


Keywords

  • Deep endometriosis
  • Fibrogenesis
  • Mouse
  • Senescence
  • Sodium tanshinone IIA sulfonate


Inhibition of cellular communication network factor 1 (CCN1)-driven senescence slows down cartilage inflammaging and osteoarthritis.


Keywords

  • CCN1
  • Cartilage inflammaging
  • Chondrocyte cluster
  • Osteoarthritis
  • Senescence


The senescence-associated matricellular protein CCN1 in plasma of human subjects with idiopathic pulmonary fibrosis.


MeSH Terms

  • Aged
  • Cellular Senescence
  • Cysteine-Rich Protein 61
  • Disease Progression
  • Enzyme-Linked Immunosorbent Assay
  • Female
  • Humans
  • Idiopathic Pulmonary Fibrosis
  • Male
  • Middle Aged
  • Outcome Assessment, Health Care
  • Predictive Value of Tests
  • Survival Rate

Keywords

  • CCN1
  • Cellular senescence
  • Idiopathic pulmonary fibrosis
  • Transplant-free survival

CCN3[править]

CCN3 Signaling Is Differently Regulated in Placental Diseases Preeclampsia and Abnormally Invasive Placenta.


Keywords

  • CCN3
  • abnormally invasive placenta
  • invasion
  • preeclampsia
  • senescence
  • trophoblast


CCN3 (NOV) Drives Degradative Changes in Aging Articular Cartilage.


Keywords

  • CCN3
  • NOV
  • SASP
  • aging
  • cellular communication network factor 3
  • oxidative stress
  • p21
  • p53
  • primary chondrocytes
  • senescence

CCND1[править]

Effects of hydrogen peroxide, doxorubicin and ultraviolet irradiation on senescence of human dental pulp stem cells.


MeSH Terms

  • Cells, Cultured
  • Cellular Senescence
  • Dental Pulp
  • Doxorubicin
  • Humans
  • Hydrogen Peroxide
  • Stem Cells
  • Ultraviolet Rays

Keywords

  • Cell cycle
  • ROS
  • Stress induced senescence
  • Ultraviolet irradiation
  • p21

CCND3[править]

The effect of aging on the biological and immunological characteristics of periodontal ligament stem cells.


Keywords

  • Aging
  • Immunosuppression
  • Osteogenic differentiation
  • Periodontal ligament stem cells
  • Peripheral blood mononuclear cells
  • Tissue engineering

CCR2[править]

Hip Fracture Leads to Transitory Immune Imprint in Older Patients.


Keywords

  • acute stress
  • aging
  • immune response
  • inflammation
  • regulation loop


The CC-chemokine receptor 2 is involved in the control of ovarian folliculogenesis and fertility lifespan in mice.


Keywords

  • Aging
  • CCR2
  • Fertility
  • Follicle
  • Ovary


Deficit of resolution receptor magnifies inflammatory leukocyte directed cardiorenal and endothelial dysfunction with signs of cardiomyopathy of obesity.


Keywords

  • inflammatory macrophage
  • kidney function
  • non-resolving inflammation
  • obesogenic aging


Tet2-mediated clonal hematopoiesis in nonconditioned mice accelerates age-associated cardiac dysfunction.


Keywords

  • Aging
  • Bone marrow transplantation
  • Cardiology
  • Hematopoietic stem cells
  • Macrophages


Inflammation and Ectopic Fat Deposition in the Aging Murine Liver Is Influenced by CCR2.


MeSH Terms

  • Aging
  • Animals
  • Body Weight
  • Chemokine CCL2
  • Disease Models, Animal
  • Female
  • Gene Expression Profiling
  • Inflammation
  • Macrophages
  • Male
  • Mice
  • Mice, Inbred C57BL
  • Non-alcoholic Fatty Liver Disease
  • Organ Size
  • Receptors, CCR2


Klotho-mediated targeting of CCL2 suppresses the induction of colorectal cancer progression by stromal cell senescent microenvironments.


MeSH Terms

  • Aged
  • Cell Line, Tumor
  • Cell Movement
  • Cell Proliferation
  • Cellular Microenvironment
  • Cellular Senescence
  • Chemokine CCL2
  • Colorectal Neoplasms
  • Disease Progression
  • Down-Regulation
  • Doxorubicin
  • Female
  • Glucuronidase
  • Human Umbilical Vein Endothelial Cells
  • Humans
  • Male
  • Middle Aged
  • NF-kappa B
  • Neoplasm Invasiveness
  • Proportional Hazards Models
  • Signal Transduction
  • Stromal Cells

Keywords

  • CCL2
  • Klotho
  • colorectal cancer
  • senescence

CCR3[править]

Low Molecular Weight Hyaluronan Induces an Inflammatory Response in Ovarian Stromal Cells and Impairs Gamete Development In Vitro.


MeSH Terms

  • Aging
  • Animals
  • Extracellular Matrix
  • Female
  • Germ Cells
  • Granulosa Cells
  • Hyaluronan Receptors
  • Hyaluronic Acid
  • Inflammation
  • Mice
  • Mice, Inbred BALB C
  • Mice, Inbred C57BL
  • Molecular Weight
  • Ovary
  • Stromal Cells

Keywords

  • hyaluronan fragments
  • inflammation
  • ovarian biology
  • reproductive aging
  • stroma

CCR5[править]

[Enhancement can do harm].


MeSH Terms

  • Adult
  • Aged
  • CRISPR-Cas Systems
  • China
  • Embryo Research
  • Gene Editing
  • Gene Silencing
  • Genetic Enhancement
  • Genome-Wide Association Study
  • HIV Infections
  • HIV-1
  • Humans
  • Longevity
  • Middle Aged
  • Receptors, CCR5

CCS[править]

Frailty Significantly Associated with a Risk for Mid-term Outcomes in Elderly Chronic Coronary Syndrome Patients: a Prospective Study.


Keywords

  • Aging
  • Canada
  • Confidence Intervals
  • Death
  • Frail Elderly
  • Frailty
  • Heart
  • Multivariate Analysis
  • Prognosis
  • Risk Factors


Microbleeds and Medial Temporal Atrophy Determine Cognitive Trajectories in Normal Aging: A Longitudinal PET-MRI Study.


Keywords

  • Atrophy
  • cognition
  • imaging markers
  • medial temporal lobe
  • microbleeds
  • normal aging


Hippocampal Volume Loss, Brain Amyloid Accumulation, and APOE Status in Cognitively Intact Elderly Subjects.


MeSH Terms

  • Aged
  • Aged, 80 and over
  • Amyloid beta-Peptides
  • Apolipoprotein E4
  • Brain
  • Cognitive Aging
  • Female
  • Hippocampus
  • Humans
  • Longitudinal Studies
  • Magnetic Resonance Imaging
  • Male
  • Positron-Emission Tomography

Keywords

  • APOE
  • Aging
  • Amyloid
  • Hippocampus


Amyloid Load, Hippocampal Volume Loss, and Diffusion Tensor Imaging Changes in Early Phases of Brain Aging.


Keywords

  • APOE genotyping
  • amyloid deposition
  • magnetic resonance imaging
  • normal aging
  • positron emission tomography


Lower bone mass is associated with subclinical atherosclerosis, endothelial dysfunction and carotid thickness in the very elderly.


Keywords

  • Aging
  • Endothelial dysfunction
  • Osteoporosis
  • Subclinical atherosclerosis

CD14[править]

Human innate immune cell crosstalk induces melanoma cell senescence.


Keywords

  • NK cell
  • cytokines
  • melanoma
  • senescence
  • slanMo


Fusion Potential of Human Osteoclasts In Vitro Reflects Age, Menopause, and In Vivo Bone Resorption Levels of Their Donors-A Possible Involvement of DC-STAMP.


Keywords

  • CTX
  • DC-STAMP
  • DNA methylation
  • aging
  • cell fusion
  • epigenetics
  • menopause
  • multinucleation
  • osteoclast
  • osteoclastogenesis


Association of CD14 with incident dementia and markers of brain aging and injury.


MeSH Terms

  • Aged
  • Aged, 80 and over
  • Aging
  • Atrophy
  • Biomarkers
  • Brain
  • Cognitive Dysfunction
  • Dementia
  • Female
  • Humans
  • Incidence
  • Lipopolysaccharide Receptors
  • Longitudinal Studies
  • Male
  • Middle Aged


Compromised Bone Healing in Aged Rats Is Associated With Impaired M2 Macrophage Function.


MeSH Terms

  • Age Factors
  • Aging
  • Animals
  • Antigens, CD
  • Antigens, Differentiation, Myelomonocytic
  • Biomarkers
  • Bone Regeneration
  • Bone and Bones
  • Female
  • Fractures, Bone
  • Gene Expression
  • Lipopolysaccharide Receptors
  • Macrophages
  • Osteotomy
  • Rats, Sprague-Dawley
  • Wound Healing

Keywords

  • CD14+ cells
  • aging
  • angiogenesis
  • bone regeneration
  • compromised healing
  • macrophage
  • monocyte

CD19[править]

Sequential treatment with aT19 cells generates memory CAR-T cells and prolongs the lifespan of Raji-B-NDG mice.


MeSH Terms

  • Animals
  • Antigens, CD19
  • Cell Line, Tumor
  • Combined Modality Therapy
  • Disease-Free Survival
  • HEK293 Cells
  • Healthy Volunteers
  • Humans
  • Immunologic Memory
  • Immunotherapy, Adoptive
  • Longevity
  • Lymphoma, B-Cell
  • Mice
  • Neoplasm Recurrence, Local
  • Receptors, Chimeric Antigen
  • Recombinant Proteins
  • Remission Induction
  • T-Lymphocytes
  • Time Factors
  • Transduction, Genetic
  • Transplantation, Autologous
  • Xenograft Model Antitumor Assays

Keywords

  • Autologous CD19 T cells
  • Chimeric antigen receptor
  • Memory T cells
  • Sequential therapy

CD27[править]

The Interplay between CD27 and CD27 B Cells Ensures the Flexibility, Stability, and Resilience of Human B Cell Memory.


Keywords

  • CD27
  • VH repertoire
  • aging
  • germinal center
  • immunodeficiency
  • immunological memory
  • memory B cells
  • pregnancy
  • spleen
  • vaccine


CMV-independent increase in CD27-CD28+ CD8+ EMRA T cells is inversely related to mortality in octogenarians.


Keywords

  • Biomarkers
  • Senescence


Compartmentalized cytotoxic immune response leads to distinct pathogenic roles of natural killer and senescent CD8 T cells in human cutaneous leishmaniasis.


MeSH Terms

  • CD56 Antigen
  • CD57 Antigens
  • Case-Control Studies
  • Cellular Senescence
  • Cytotoxicity, Immunologic
  • Female
  • Gene Expression Regulation
  • Host-Parasite Interactions
  • Humans
  • Interferon-gamma
  • Killer Cells, Natural
  • Lectins, C-Type
  • Leishmania braziliensis
  • Leishmaniasis, Cutaneous
  • Male
  • Oligosaccharides
  • Receptors, Immunologic
  • Severity of Illness Index
  • Sialyl Lewis X Antigen
  • Signal Transduction
  • Skin
  • T-Lymphocytes, Cytotoxic

Keywords

Leishmania braziliensis

  • CD8+ T cells
  • cellular senescence
  • cutaneous leishmaniasis
  • immunopathology
  • natural killer cells


CD27- IgD- B cell memory subset associates with inflammation and frailty in elderly individuals but only in males.


Keywords

  • Aging
  • B cell
  • Frailty
  • Immunosenescence

CD28[править]

Premature CD4 T Cells Senescence Induced by Chronic Infection in Patients with Acute Coronary Syndrome.


Keywords

  • CD28null T cells
  • CD4+ T cells
  • acute coronary syndrome
  • immunosenescence
  • infection


The IMMENSE Study: The Interplay Between iMMune and ENdothelial Cells in Mediating Cardiovascular Risk in Systemic Lupus Erythematosus.


Keywords

  • angiogenic T cells
  • cardiovascular risk
  • endothelial progenitor cells
  • immunosenescence
  • systemic lupus erythematosus


Emergence of T cell immunosenescence in diabetic chronic kidney disease.


Keywords

  • BMI
  • CKD
  • Diabetes
  • Immunosenescence
  • T cell


The relationship between Chlamydia pneumoniae infection and CD4/CD8 ratio, lymphocyte subsets in middle-aged and elderly individuals.


Keywords

  • CD4/CD8 ratio
  • Chlamydia pneumoniae
  • Immune profile
  • Immunosenescence
  • Lymphocyte subsets


Next steps in mechanisms of inflammaging.


Keywords

  • Aging
  • autophagy
  • glutathione
  • membrane potential
  • mitochondria
  • oxidative stress


A randomized pilot trial to evaluate the benefit of the concomitant use of atorvastatin and Raltegravir on immunological markers in protease-inhibitor-treated subjects living with HIV.


MeSH Terms

  • Adult
  • Anti-HIV Agents
  • Anticholesteremic Agents
  • Atorvastatin
  • CD4-Positive T-Lymphocytes
  • CD8-Positive T-Lymphocytes
  • Female
  • HIV Infections
  • HIV Protease Inhibitors
  • Humans
  • Immunosenescence
  • Inflammation
  • Lymphocyte Activation
  • Male
  • Middle Aged
  • Pilot Projects
  • Raltegravir Potassium


Aging affects responsiveness of peripheral blood mononuclear cells to immunosuppression of periodontal ligament stem cells.


Keywords

  • Periodontal ligament stem cells
  • T lymphocytes
  • age
  • coculture
  • cytokines
  • immunophenotyping
  • immunosenescence
  • immunosuppression
  • peripheral blood mononuclear cells


Comparison of Donepezil, Memantine, Melatonin, and Liuwei Dihuang Decoction on Behavioral and Immune Endocrine Responses of Aged Senescence-Accelerated Mouse Resistant 1 Mice.


Keywords

  • Liuwei Dihuang decoction
  • aging
  • cognition
  • immune response
  • inflammation


Immunosenescent characteristics of T cells in young patients following haploidentical haematopoietic stem cell transplantation from parental donors.


Keywords

  • CD28− T cells
  • HaploSCT
  • immune monitoring
  • immunosenescence
  • telomere length


Diagnosis-independent loss of T-cell costimulatory molecules in individuals with cytomegalovirus infection.


Keywords

  • Biological aging
  • Cytomegalovirus
  • Depression
  • Immunosenescence
  • Major depressive disorder
  • Sex differences
  • T-cells


Accelerated immunosenescence in rheumatoid arthritis: impact on clinical progression.


Keywords

  • Ageing
  • Cell senescence
  • Cognitive impairment
  • Immune ageing
  • Rheumatoid arthritis


Accelerated immune aging was correlated with lupus-associated brain fog in reproductive-age systemic lupus erythematosus patients.


Keywords

  • immunosenescence
  • lupus-associated brain fog
  • systemic lupus erythematosus


T cells, aging and senescence.


Keywords

  • Aging
  • Senescence
  • T cells


Liver fibrosis and accelerated immune dysfunction (immunosenescence) among HIV-infected Russians with heavy alcohol consumption - an observational cross-sectional study.


MeSH Terms

  • Adult
  • Alcoholism
  • CD28 Antigens
  • CD4-Positive T-Lymphocytes
  • CD57 Antigens
  • CD8-Positive T-Lymphocytes
  • Cross-Sectional Studies
  • Female
  • HIV Infections
  • Hepatitis C
  • Humans
  • Immunologic Memory
  • Immunosenescence
  • Leukocyte Common Antigens
  • Linear Models
  • Liver Cirrhosis, Alcoholic
  • Male
  • Phenotype
  • Randomized Controlled Trials as Topic
  • Russia
  • Zinc

Keywords

  • Alcohol
  • HIV
  • Immune senescence
  • Liver fibrosis
  • Russia


Effect of Allogenic Bone Marrow Mesenchymal Stem Cell Transplantation on T Cells of Old Mice.


Keywords

  • aging
  • cellular senescence
  • memory T cells
  • stem cell


Peripheral antibody concentrations are associated with highly differentiated T cells and inflammatory processes in the human bone marrow.


Keywords

  • Aging
  • Antibodies
  • B cells
  • Bone marrow
  • Exhaustion
  • Immunosenescence
  • Inflammation
  • Pro-inflammatory
  • Senescence

CD33[править]

Maximum reproductive lifespan correlates with CD33rSIGLEC gene number: Implications for NADPH oxidase-derived reactive oxygen species in aging.


MeSH Terms

  • Animals
  • Gene Dosage
  • Humans
  • Longevity
  • NADPH Oxidases
  • Neutrophils
  • Reactive Oxygen Species
  • Sialic Acid Binding Ig-like Lectin 3
  • Whale, Killer

Keywords

CD33rSIGLEC

  • NADPH-oxidase
  • prolonged post-reproductive lifespan
  • reactive oxygen species

CD34[править]

Comparing the Effect of TGF-β Receptor Inhibition on Human Perivascular Mesenchymal Stromal Cells Derived from Endometrium, Bone Marrow and Adipose Tissues.


Keywords

  • SUSD2
  • adipose tissue
  • apoptosis
  • bone marrow
  • clonogenicity
  • endometrium
  • menstrual fluid
  • perivascular mesenchymal stromal cells
  • placenta
  • senescence


ACE2/ACE imbalance and impaired vasoreparative functions of stem/progenitor cells in aging.


Keywords

  • ACE2
  • Aging
  • Angiotensin-(1-7)
  • Hematopoietic stem/progenitor cells
  • Ischemia


Innovative Mind-Body Intervention Day Easy Exercise Increases Peripheral Blood CD34 Cells in Adults.


Keywords

  • CD34+ cells
  • aging
  • day easy exercise
  • mind–body intervention


Human Thymic Involution and Aging in Humanized Mice.


Keywords

  • aging
  • human
  • humanized mouse
  • recent thymic emigrants
  • thymus involution


Coinhibition of activated p38 MAPKα and mTORC1 potentiates stemness maintenance of HSCs from SR1-expanded human cord blood CD34 cells via inhibition of senescence.


Keywords

  • HSC stemness maintenance
  • Stem Regenin 1
  • cellular senescence
  • ex vivo expansion
  • human cord blood CD34+ cells
  • mammalian target of rapamycin complex 1
  • p38 mitogen-activated protein kinase α


Bulk and single-cell gene expression analyses reveal aging human choriocapillaris has pro-inflammatory phenotype.


MeSH Terms

  • Age Factors
  • Aged
  • Aged, 80 and over
  • Aging
  • Choroid
  • Endothelial Cells
  • Female
  • Gene Expression Regulation
  • Humans
  • Infant
  • Infant, Newborn
  • Inflammation
  • Inflammation Mediators
  • Macular Degeneration
  • Male
  • Middle Aged
  • Phenotype
  • Sequence Analysis, RNA
  • Single-Cell Analysis

Keywords

  • Age-related macular degeneration
  • Choriocapillaris
  • Choroid
  • Infant
  • Pericytes
  • Single-cell


Mesenchymal stem cells repair bone marrow damage of aging rats and regulate autophagy and aging genes.


Keywords

  • aging
  • autophagy
  • bone marrow injury
  • mesenchymal stem cells
  • repair


Immune cell extracellular vesicles and their mitochondrial content decline with ageing.


Keywords

  • Ageing
  • Apoptotic bodies
  • Exosomes
  • Extracellular vesicles
  • Immune cells
  • Immunosenescence
  • Inflammageing
  • Microvesicles
  • Mitochondria


Young and elderly oral squamous cell carcinoma patients present similar angiogenic profile and predominance of M2 macrophages: Comparative immunohistochemical study.


MeSH Terms

  • Adult
  • Aged
  • Aged, 80 and over
  • Antigens, CD
  • Antigens, Differentiation, Myelomonocytic
  • Carcinoma, Squamous Cell
  • Female
  • Humans
  • Immunohistochemistry
  • Immunosenescence
  • Macrophages
  • Male
  • Middle Aged
  • Mouth Neoplasms
  • Neovascularization, Pathologic
  • Receptors, Cell Surface
  • Tumor Microenvironment

Keywords

  • M1 and M2 macrophages
  • angiogenesis
  • immunohistochemistry
  • immunosenescence
  • oral squamous cell carcinoma

CD36[править]

Liver osteopontin is required to prevent the progression of age-related nonalcoholic fatty liver disease.


Keywords

  • Osteopontin
  • aging
  • lipid metabolism
  • nonalcoholic fatty liver disease
  • p53
  • senescence


Reduction of senescence-associated beta-galactosidase activity by vitamin E in human fibroblasts depends on subjects' age and cell passage number.


Keywords

  • CD36 scavenger receptor
  • alpha-tocopherol
  • exosomes
  • extracellular vesicles
  • gene expression
  • lysosome
  • senescence
  • signal transduction
  • vitamin E


Niacin-mediated rejuvenation of macrophage/microglia enhances remyelination of the aging central nervous system.


Keywords

  • Aging
  • Macrophages
  • Microglia
  • Oligodendrocyte progenitor cells
  • Phagocytosis
  • Remyelination

CD38[править]

Re-equilibration of imbalanced NAD metabolism ameliorates the impact of telomere dysfunction.


Keywords

  • CD38 NADase
  • NAD metabolism
  • mitochondrial impairment
  • replicative senescence
  • telomere biology disorders


TNFRSF12A and CD38 Contribute to a Vicious Circle for Chronic Obstructive Pulmonary Disease by Engaging Senescence Pathways.


Keywords

  • aging
  • chronic inflammation
  • lung
  • network analysis
  • senescence
  • tissue remodeling


Aging alters acetylation status in skeletal and cardiac muscles.


Keywords

  • Aging
  • CD38
  • Deacetylation
  • NAD+
  • PARP
  • SIRT
  • Skeletal muscle


CD38 in Neurodegeneration and Neuroinflammation.


Keywords

  • ALS.
  • Alzheimer’s disease
  • CD38
  • NAD
  • Parkinson’s disease
  • aging
  • neurodegeneration
  • neuroinflammation


CD38, a Receptor with Multifunctional Activities: From Modulatory Functions on Regulatory Cell Subsets and Extracellular Vesicles, to a Target for Therapeutic Strategies.


MeSH Terms

  • ADP-ribosyl Cyclase 1
  • Aging
  • Animals
  • Antibodies, Monoclonal
  • B-Lymphocytes, Regulatory
  • Cell Line
  • Extracellular Vesicles
  • Humans
  • Infections
  • Membrane Glycoproteins
  • Mice
  • Neoplasms
  • T-Lymphocytes, Regulatory

Keywords

  • CD38
  • adenosine
  • immune-modulation
  • regulatory cells


CD38 Deficiency Alleviates D-Galactose-Induced Myocardial Cell Senescence Through NAD /Sirt1 Signaling Pathway.


Keywords

  • CD38
  • D-galactose
  • NAD+
  • heart senescence
  • oxidative stress

CD4[править]

Identification of Key Genes and Potential New Biomarkers for Ovarian Aging: A Study Based on RNA-Sequencing Data.


Keywords

  • GEO database
  • bioinformatics
  • biomarker
  • immune cell infiltration
  • ovarian aging


Distinct Age-Related Epigenetic Signatures in CD4 and CD8 T Cells.


Keywords

  • T-cell
  • T-cell homeostasis
  • aging
  • chromatin accessibility
  • epigenetics
  • ribosomal proteins


IL-1β-MyD88-mTOR Axis Promotes Immune-Protective IL-17A Foxp3 Cells During Mucosal Infection and Is Dysregulated With Aging.


Keywords

  • Candida
  • Foxp3
  • IL-1β
  • Treg
  • Treg17
  • aging
  • fungal infection
  • senescence


Thymus involution sets the clock of declined immunity and repair with aging.


Keywords

  • Aging
  • Chronic systemic inflammation
  • Dysregulated CD4 T cells
  • Immune-mediated repair
  • Thymus


Food insecurity and T-cell dysregulation in women living with HIV on antiretroviral therapy.


Keywords

  • HIV
  • exhaustion
  • food insecurity
  • immune activation
  • senescence


Rapamycin Eyedrops Increased CD4 Foxp3 Cells and Prevented Goblet Cell Loss in the Aged Ocular Surface.


Keywords

  • aging
  • dry eye
  • goblet cell
  • inflammation
  • lacrimal gland
  • ocular surface
  • rapamycin


Antioxidants N-Acetylcysteine and Vitamin C Improve T Cell Commitment to Memory and Long-Term Maintenance of Immunological Memory in Old Mice.


Keywords

  • NAC
  • T cells
  • aging
  • antioxidants
  • immunosenescence
  • vaccination
  • vitamin C


Evolution of comorbidities in people living with HIV between 2004 and 2014: cross-sectional analyses from ANRS CO3 Aquitaine cohort.


Keywords

  • Aging
  • Cardiovascular events
  • Chronic kidney disease
  • Comorbidities
  • HIV


Impact of age on CD4 recovery and viral suppression over time among adults living with HIV who initiated antiretroviral therapy in the African Cohort Study.


Keywords

  • Elders on antiretroviral drugs
  • HIV and aging
  • HIV treatment outcomes
  • Sub-saharan Africa


hPMSCs protects against D-galactose-induced oxidative damage of CD4 T cells through activating Akt-mediated Nrf2 antioxidant signaling.


Keywords

  • Aging
  • CD4+ T cells
  • Nrf2
  • Oxidative stress
  • Senescence-associated secretoryphenotype
  • hPMSC


Substantial gap in primary care: older adults with HIV presenting late to care.


Keywords

  • Aging population
  • HIV
  • Older adults
  • Risk
  • Stigma
  • Testing


Quantitative Digitography Measures Fine Motor Disturbances in Chronically Treated HIV Similar to Parkinson's Disease.


Keywords

  • HIV—human immunodeficiency virus
  • Parkinson’s disease
  • aging
  • fine motor activities
  • motor control


Monocyte and T Cell Immune Phenotypic Profiles Associated With Age Advancement Differ Between People With HIV, Lifestyle-Comparable Controls and Blood Donors.


Keywords

  • HIV
  • T cell
  • aging
  • immune activation
  • immune dysfunction
  • inflammation
  • monocyte


HIV and three dimensions of Wisdom: Association with cognitive function and physical and mental well-being: For: Psychiatry Research.


Keywords

  • Affective
  • Aging
  • Aids
  • Compassion
  • Reflective


CD8 T cells are present at low levels in the white matter with physiological and pathological aging.


Keywords

  • aging
  • neuroscience
  • pathology


Immunotherapy in older patients with cancer.


Keywords

  • Ageing
  • Cancer
  • Elderly
  • Immunosenescence
  • Immunotherapy
  • Old people
  • Oncogeriatry


Multiple genetic programs contribute to CD4 T cell memory differentiation and longevity by maintaining T cell quiescence.


Keywords

  • CD4 T cell
  • Cell longevity
  • Gene
  • Genetic programs
  • Memory T cell
  • Memory cell markers


Conventional Treatment for Multiple Myeloma Drives Premature Aging Phenotypes and Metabolic Dysfunction in T Cells.


Keywords

  • T cell
  • aging
  • autologous stem cell transplant
  • metabolism
  • myeloma


Immunosenescence: the role of age in multiple sclerosis.


Keywords

  • Ageing
  • Envejecimiento
  • Esclerosis múltiple
  • Esclerosis múltiple de comienzo tardío
  • Immunosenescence
  • Inmunosenescencia
  • Late-onset multiple sclerosis
  • Multiple sclerosis


Umbilical cord mesenchymal stem cells protect thymus structure and function in aged C57 mice by downregulating aging-related genes and upregulating autophagy- and anti-oxidative stress-related genes.


Keywords

  • aged
  • senescence
  • thymus
  • transplantation
  • umbilical cord mesenchymal stem cells


Impaired Cytotoxic CD8 T Cell Response in Elderly COVID-19 Patients.


MeSH Terms

  • Aged, 80 and over
  • Antigens, CD
  • Betacoronavirus
  • CD4-Positive T-Lymphocytes
  • CD8-Positive T-Lymphocytes
  • COVID-19
  • Coronavirus Infections
  • Cytotoxins
  • Female
  • Humans
  • Immunity, Cellular
  • Male
  • Middle Aged
  • Pandemics
  • Pneumonia, Viral
  • SARS-CoV-2
  • T-Lymphocyte Subsets
  • T-Lymphocytes, Cytotoxic

Keywords

  • CD4+
  • CD8+
  • COVID-19
  • PD-1
  • SARS-CoV-2
  • aging
  • cytotoxic T cells
  • granzyme
  • perforin


What are the roles of antibodies versus a durable, high quality T-cell response in protective immunity against SARS-CoV-2?


Keywords

  • Antibodies
  • Antibody-dependent enhancement
  • CD8 T-cells
  • COVID-19
  • Durable immunity
  • Protective immunity
  • SARS
  • SARS-CoV-2
  • T cell lifespan
  • T-cell epitopes
  • T-cells
  • Vaccines
  • Yellow Fever Vaccine


Per2 Upregulation in Circulating Hematopoietic Progenitor Cells During Chronic HIV Infection.


Keywords

  • HIV
  • Sirtuin 1
  • hematopoietic progenitor cells
  • period circadian clock 2
  • senescence
  • telomere length


COVID-19: age, Interleukin-6, C-reactive protein, and lymphocytes as key clues from a multicentre retrospective study.


Keywords

  • ACE2
  • C-reactive protein
  • COVID-19
  • Immunity
  • Immunosenescence
  • Interleukin-6
  • Lymphocytes
  • Renin-angiotensin system
  • Severe acute respiratory syndrome coronavirus 2
  • Spain


Immunosenescence profiles are not associated with muscle strength, physical performance and sarcopenia risk in very old adults: The Newcastle 85+ Study.


Keywords

  • immunosenescence
  • lymphocyte compartments
  • physical performance
  • sarcopenia
  • very old adults


Homeostasis and the functional roles of CD4 Treg cells in aging.


Keywords

  • Aging
  • Autoimmunity
  • Cancer
  • FOXP3
  • Immune senescence
  • Immune suppression
  • Inflammaging
  • Regulatory T cells
  • T helper 17
  • Treg


A Comprehensive Evaluation of the Impact of Bovine Milk Containing Different Beta-Casein Profiles on Gut Health of Ageing Mice.


Keywords

  • A2 beta-casein
  • SCFAs
  • elderly
  • gut inflammation
  • gut microbiota
  • gut morphology
  • immunosenescence


Premature aging of circulating T cells predicts all-cause mortality in hemodialysis patients.


Keywords

  • Hemodialysis
  • Inflammation
  • Mortality
  • T cell aging
  • naïve T cells


In-depth immune cellular profiling reveals sex-specific associations with frailty.


Keywords

  • Frailty
  • Healthy aging
  • Immune cellular profiling
  • Immune homeostasis
  • Immunosenescence
  • Sex-specific immune profile


CD70 contributes to age-associated T cell defects and overwhelming inflammatory responses.


Keywords

  • CD70
  • T cell aging
  • co-inhibitory molecules
  • immunosenescence
  • overwhelming inflammatory responses


Comparison of Overall and Comorbidity-Free Life Expectancy Between Insured Adults With and Without HIV Infection, 2000-2016.


MeSH Terms

  • Adult
  • Chronic Disease
  • Cohort Studies
  • Comorbidity
  • Female
  • HIV Infections
  • Humans
  • Insurance, Health
  • Life Expectancy
  • Male
  • Middle Aged


Comparative Analysis of Age-Related Changes in Lacrimal Glands and Meibomian Glands of a C57BL/6 Male Mouse Model.


Keywords

  • aging
  • dry eye
  • inflammation
  • lacrimal glands
  • meibomian glands
  • oxidative stress
  • senescence


Thymus aging in mice deficient in either EphB2 or EphB3, two master regulators of thymic epithelium development.


Keywords

  • senescence
  • thymic epithelial cells
  • thymocytes


CD8 T-cell senescence and skewed lymphocyte subsets in young Dyskeratosis Congenita patients with PARN and DKC1 mutations.


Keywords

DKC1

PARN

  • Dyskeratosis Congenita
  • primary immunodeficiency
  • senescence
  • telomere


Short-Term Environmental Enrichment is a Stronger Modulator of Brain Glial Cells and Cervical Lymph Node T Cell Subtypes than Exercise or Combined Exercise and Enrichment.


Keywords

  • Aging
  • Astrocytes
  • Environmental enrichment
  • Microglia
  • Physical exercise
  • T cells


Viral and host factors related to the clinical outcome of COVID-19.


MeSH Terms

  • Adolescent
  • Adult
  • Aged
  • Aged, 80 and over
  • Aging
  • Animals
  • Asymptomatic Infections
  • Betacoronavirus
  • COVID-19
  • China
  • Cohort Studies
  • Coronavirus Infections
  • Critical Illness
  • Disease Progression
  • Evolution, Molecular
  • Female
  • Genetic Variation
  • Genome, Viral
  • Hospitalization
  • Host-Pathogen Interactions
  • Humans
  • Inflammation Mediators
  • Interleukin-6
  • Interleukin-8
  • Lymphocyte Count
  • Lymphopenia
  • Male
  • Middle Aged
  • Pandemics
  • Phylogeny
  • Pneumonia, Viral
  • Respiratory Distress Syndrome
  • SARS-CoV-2
  • T-Lymphocytes
  • Time Factors
  • Treatment Outcome
  • Virulence
  • Virus Shedding
  • Young Adult
  • Zoonoses


Use of comedications and potential drug-drug interactions in people living with HIV in China.


Keywords

  • Aging
  • China
  • Co-medication
  • Drug-drug interaction
  • HIV


CD4 T helper 17 cell response of aged mice promotes prostate cancer cell migration and invasion.


MeSH Terms

  • Aging
  • Animals
  • CD4-Positive T-Lymphocytes
  • Cell Differentiation
  • Cell Line, Tumor
  • Cell Movement
  • Humans
  • Inflammation
  • Male
  • Mice
  • Mice, Inbred C57BL
  • Mice, Knockout
  • Models, Animal
  • NF-kappa B
  • Neoplasm Invasiveness
  • PC-3 Cells
  • Prostatic Neoplasms
  • Th17 Cells

Keywords

  • CD4+ T cell-secreted factors
  • PCa cells
  • Th17 cytokines
  • aging
  • inflammation


The Rules of Human T Cell Fate [i]in vivo[/i].


Keywords

  • decision
  • fate
  • half-life
  • labeling
  • lifespan
  • lymphocyte
  • mathematical model
  • proliferation


CD4/CD8 ratio, comorbidities, and aging in treated HIV infected individuals on viral suppression.


Keywords

  • CD4/CD8 ratio
  • HIV
  • aging
  • comorbidities


The effects of advanced maternal age on T-cell subsets at the maternal-fetal interface prior to term labor and in the offspring: a mouse study.


MeSH Terms

  • Adult
  • Aging
  • Animals
  • Female
  • Humans
  • Live Birth
  • Mice
  • Mice, Transgenic
  • Placenta
  • Pregnancy
  • T-Lymphocyte Subsets

Keywords

  • birth weight
  • neonate
  • offspring
  • pregnancy
  • preterm labor


Structural and Functional Changes in the Mesenteric Lymph Nodes in Humans during Aging.


Keywords

  • age-related involution
  • aging
  • immune system
  • immunomorphology
  • mesenteric lymph nodes


Neurocognitive Functioning is Associated with Self-Reported and Performance-Based Treatment Management Abilities in People Living with HIV with Low Health Literacy.


MeSH Terms

  • Adult
  • Cognition
  • Cross-Sectional Studies
  • HIV Infections
  • Health Literacy
  • Humans
  • Neuropsychological Tests
  • Self Report

Keywords

  • Adherence
  • Aging
  • Cognitive impairment
  • HIV/AIDS
  • Health illiteracy
  • Observational study


Blockade of Stat3 oncogene addiction induces cellular senescence and reveals a cell-nonautonomous activity suitable for cancer immunotherapy.


Keywords

  • Stat3
  • immune checkpoint blockade
  • immunotherapy
  • oncogene addiction
  • senescence


Age-related changes in T lymphocytes of patients with head and neck squamous cell carcinoma.


Keywords

  • Aging
  • Head and neck cancer
  • Immune escape
  • Immunosenescence
  • T cells


Immunological history governs human stem cell memory CD4 heterogeneity via the Wnt signaling pathway.


MeSH Terms

  • Aging
  • Animals
  • Antigens, CD
  • CD4-Positive T-Lymphocytes
  • Gene Expression Profiling
  • HIV Infections
  • Humans
  • Immunologic Memory
  • Intercellular Signaling Peptides and Proteins
  • Mice
  • Precursor Cells, T-Lymphoid
  • Thymus Gland
  • Wnt Signaling Pathway
  • beta Catenin


Estimating HIV Management and Comorbidity Costs Among Aging HIV Patients in the United States: A Systematic Review.


MeSH Terms

  • Anti-HIV Agents
  • CD4 Lymphocyte Count
  • Comorbidity
  • Cost-Benefit Analysis
  • HIV Infections
  • Health Care Costs
  • Humans
  • Life Expectancy
  • United States


Sex Differences in People Aging With HIV.


MeSH Terms

  • Aged
  • Aging
  • Alcohol Drinking
  • Body Composition
  • CD4 Lymphocyte Count
  • CD4-CD8 Ratio
  • CD4-Positive T-Lymphocytes
  • Cohort Studies
  • Cross-Sectional Studies
  • Female
  • Frailty
  • HIV Infections
  • Humans
  • Male
  • Middle Aged
  • Muscle Strength
  • Prospective Studies


Identification of Differentially Expressed miRNAs in the Response of Spleen CD4 T Cells to Electroacupuncture in Senescence-Accelerated Mice.


MeSH Terms

  • Aging
  • Animals
  • Antagomirs
  • CD4-Positive T-Lymphocytes
  • Cell Differentiation
  • Cytokines
  • Down-Regulation
  • Electroacupuncture
  • Female
  • Gene Regulatory Networks
  • High-Throughput Nucleotide Sequencing
  • Male
  • Mice
  • Mice, Inbred C57BL
  • MicroRNAs
  • Sequence Analysis, RNA
  • Spleen
  • Up-Regulation

Keywords

  • CD4+ T cell
  • Deep sequencing
  • Electroacupuncture
  • Immunological aging
  • miRNA


Thymus Involution and Intravenous Drug Abuse.


MeSH Terms

  • Adolescent
  • Adult
  • Aging
  • Atrophy
  • CD4-Positive T-Lymphocytes
  • CD8-Positive T-Lymphocytes
  • Calcinosis
  • Case-Control Studies
  • Drug Users
  • Female
  • Forensic Pathology
  • Hepatitis C, Chronic
  • Humans
  • Male
  • Middle Aged
  • Substance Abuse, Intravenous
  • Thymus Gland
  • Young Adult


Depletion of CD4 T cells provides therapeutic benefits in aged mice after ischemic stroke.


MeSH Terms

  • Aging
  • Animals
  • Behavior, Animal
  • Brain Chemistry
  • Brain Ischemia
  • CD4-Positive T-Lymphocytes
  • Chemokines
  • Cytokines
  • Female
  • Infarction, Middle Cerebral Artery
  • Inflammation
  • Male
  • Mice
  • Mice, Inbred C57BL
  • Stroke
  • Treatment Outcome

Keywords

  • Age
  • CD4 T cells
  • CXCL10
  • Inflammation
  • Stroke


Immunological and Virological Responses in Older HIV-Infected Adults Receiving Antiretroviral Therapy: An Evidence-Based Meta-Analysis.


MeSH Terms

  • Aged
  • Aging
  • Anti-HIV Agents
  • HIV Infections
  • Humans
  • Middle Aged


African Mitochondrial DNA Haplogroup L2 Is Associated With Slower Decline of β-cell Function and Lower Incidence of Diabetes Mellitus in Non-Hispanic, Black Women Living With Human Immunodeficiency Virus.


Keywords

  • HIV
  • aging
  • diabetes mellitus
  • mitochondrial genetics


DP1 Activation Reverses Age-Related Hypertension Via NEDD4L-Mediated T-Bet Degradation in T Cells.


MeSH Terms

  • Aged
  • Aging
  • Animals
  • Antihypertensive Agents
  • CD4-Positive T-Lymphocytes
  • Cyclic AMP-Dependent Protein Kinases
  • Cytokines
  • Humans
  • Hypertension
  • Mice
  • Mice, Inbred C57BL
  • Nedd4 Ubiquitin Protein Ligases
  • Prostaglandin D2
  • Receptors, Prostaglandin
  • Signal Transduction
  • Sp1 Transcription Factor
  • Superoxides
  • T-Box Domain Proteins
  • Th1 Cells
  • Ubiquitination

Keywords

  • D-prostanoid receptor 1
  • aging
  • hypertension
  • lymphocyte
  • prostaglandin (PG) D2


An Emerging Concern-High Rates of Frailty among Middle-aged and Older Individuals Living with HIV.


Keywords

  • accelerated aging
  • anti-retroviral therapy
  • frailty
  • frailty index
  • geriatric syndrome
  • human immunodeficiency virus (HIV)
  • multimorbidity
  • vulnerability


Higher Acuity Resource Utilization With Older Age and Poorer HIV Control in Adolescents and Young Adults in the HIV Research Network.


MeSH Terms

  • Adolescent
  • Adult
  • Aging
  • Anti-Retroviral Agents
  • CD4 Lymphocyte Count
  • Drug Administration Schedule
  • Female
  • HIV Infections
  • HIV-1
  • Humans
  • Male
  • Medication Adherence
  • Viral Load
  • Young Adult


Mitochondrial DNA Haplogroups and Frailty in Adults Living with HIV.


Keywords

  • HIV
  • aging
  • frailty
  • haplotypes
  • mitochondria
  • sarcopenia


Gallic acid attenuates thymic involution in the d-galactose induced accelerated aging mice.


Keywords

  • Aging
  • FoxN1
  • Gallic acid
  • Thymus
  • d-galactose


Mitochondrial mass governs the extent of human T cell senescence.


MeSH Terms

  • Adenosine Triphosphate
  • Adult
  • CD4-Positive T-Lymphocytes
  • CD8-Positive T-Lymphocytes
  • Cell Movement
  • Cell Proliferation
  • Cellular Senescence
  • Glucose
  • Glycolysis
  • Humans
  • Immunosenescence
  • Leukocyte Common Antigens
  • Microscopy, Electron, Transmission
  • Middle Aged
  • Mitochondria
  • Rotenone

Keywords

  • T cell
  • aging
  • metabolism
  • mitochondria
  • senescence


T cells and immune functions of plasma extracellular vesicles are differentially modulated from adults to centenarians.


MeSH Terms

  • Adult
  • Aged
  • Aged, 80 and over
  • Extracellular Vesicles
  • Female
  • Humans
  • Immunosenescence
  • Lymphocyte Activation
  • Male
  • Middle Aged
  • T-Lymphocytes

Keywords

  • T cells
  • aging
  • centenarians
  • extracellular vesicles (EVs)
  • immunosenescence


Defects in Antiviral T Cell Responses Inflicted by Aging-Associated miR-181a Deficiency.


MeSH Terms

  • Aging
  • Animals
  • CD4-Positive T-Lymphocytes
  • CD8-Positive T-Lymphocytes
  • Disease Models, Animal
  • Lymphocytic Choriomeningitis
  • Lymphocytic choriomeningitis virus
  • Mice
  • MicroRNAs

Keywords

  • CD8 effector T cell
  • T cell repertoire
  • antiviral response
  • immune aging
  • immunosenescence
  • microRNA


Increased Prevalence of Neurocognitive Impairment in Aging People Living With Human Immunodeficiency Virus: The ANRS EP58 HAND 55-70 Study.


Keywords

  • Frascati criteria
  • HAND
  • HIV
  • aging
  • neurocognitive impairment


Age-associated changes in human CD4 T cells point to mitochondrial dysfunction consequent to impaired autophagy.


MeSH Terms

  • Adult
  • Aged
  • CD4-Positive T-Lymphocytes
  • Cell Respiration
  • Humans
  • Immunosenescence
  • Longitudinal Studies
  • Mitochondria
  • Mitophagy
  • Young Adult

Keywords

  • CD4+ T cells
  • aging
  • autophagy
  • mitochondria
  • proteomics


Sex Differences in the Blood Transcriptome Identify Robust Changes in Immune Cell Proportions with Aging and Influenza Infection.


MeSH Terms

  • Aging
  • CD4-Positive T-Lymphocytes
  • Female
  • Humans
  • Influenza, Human
  • Male
  • Monocytes
  • Sex Characteristics
  • Transcriptome

Keywords

  • CD4(+) T cells
  • aging
  • immune system
  • immunology
  • influenza
  • meta-analysis
  • monocytes
  • multi-cohort analysis
  • sex differences
  • transcriptome


Going Beyond Giving Antiretroviral Therapy: Multimorbidity in Older People Aging with HIV in Nigeria.


Keywords

  • ART
  • PLWH
  • aging
  • multimorbidity
  • quality of life


Alterations in composition of immune cells and impairment of anti-tumor immune response in aged oral cancer-bearing mice.


MeSH Terms

  • Aged
  • Animals
  • Cell Line, Tumor
  • Cell Proliferation
  • Female
  • Humans
  • Immunotherapy
  • Mice

Keywords

  • Aging
  • Immune check-point molecules
  • Immunosenescence
  • Immunotherapy
  • Myeloid derived suppressor cells
  • Oral cancer
  • Regulatory T cells


LTA1 is a safe, intranasal enterotoxin-based adjuvant that improves vaccine protection against influenza in young, old and B-cell-depleted (μMT) mice.


MeSH Terms

  • Adjuvants, Immunologic
  • Administration, Intranasal
  • Aging
  • Animals
  • Antibodies
  • Antibody Formation
  • B-Lymphocytes
  • CD4-Positive T-Lymphocytes
  • Dose-Response Relationship, Immunologic
  • Enterotoxins
  • Female
  • Immunity, Mucosal
  • Immunization
  • Inflammation
  • Influenza A Virus, H1N1 Subtype
  • Lung
  • Lymphocyte Activation
  • Lymphocyte Depletion
  • Mast Cells
  • Mice, Inbred C57BL
  • Orthomyxoviridae Infections


Thymus Imaging Detection and Size Is Inversely Associated With Metabolic Syndrome and Frailty in People With HIV.


Keywords

  • HIV
  • aging
  • frailty
  • metabolic syndrome
  • thymus


Alterations in peripheral T cell and B cell subsets in patients with osteoarthritis.


MeSH Terms

  • Aged
  • Aging
  • B-Lymphocyte Subsets
  • Case-Control Studies
  • Female
  • Humans
  • Male
  • Middle Aged
  • Osteoarthritis, Knee
  • T-Lymphocyte Subsets

Keywords

  • B cell
  • Lymphocyte
  • Osteoarthritis
  • T cell


Short Communication: Carotid Intima-Media Thickness Is Not Associated with Neurocognitive Impairment Among People Older than 50 Years With and Without HIV Infection from Thailand.


MeSH Terms

  • Aging
  • Anti-Retroviral Agents
  • Cardiovascular Diseases
  • Carotid Intima-Media Thickness
  • Cross-Sectional Studies
  • Depression
  • Female
  • HIV Infections
  • Humans
  • Male
  • Middle Aged
  • Neurocognitive Disorders
  • Quality of Life
  • Risk Factors
  • Thailand

Keywords

  • HIV
  • aging
  • carotid intima-media thickness
  • neurocognitive


Implications of Immune Checkpoint Expression During Aging in HIV-Infected People on Antiretroviral Therapy.


MeSH Terms

  • Adult
  • Aged
  • Aging
  • Anti-HIV Agents
  • Antiretroviral Therapy, Highly Active
  • CD4-Positive T-Lymphocytes
  • CD8-Positive T-Lymphocytes
  • Cytokines
  • Female
  • Flow Cytometry
  • Gene Expression
  • HIV Infections
  • HIV-1
  • Hepatitis A Virus Cellular Receptor 2
  • Humans
  • Leukocytes, Mononuclear
  • Male
  • Middle Aged
  • Young Adult
  • gag Gene Products, Human Immunodeficiency Virus

Keywords

  • aging
  • immune checkpoint molecules
  • virus suppression


Age-related alterations in human gut CD4 T cell phenotype, T helper cell frequencies, and functional responses to enteric bacteria.


MeSH Terms

  • Adolescent
  • Adult
  • Age Factors
  • Aged
  • Aged, 80 and over
  • CD4-Positive T-Lymphocytes
  • Female
  • Gastrointestinal Microbiome
  • Humans
  • Interleukin-17
  • Intestinal Mucosa
  • Male
  • Middle Aged
  • Phenotype
  • Th1 Cells
  • Th17 Cells
  • Young Adult

Keywords

  • T helper cells
  • aging
  • gut
  • human


Determinants of blood telomere length in antiretroviral treatment-naïve HIV-positive participants enrolled in the NEAT 001/ANRS 143 clinical trial.


MeSH Terms

  • Adult
  • Aged
  • Anti-Retroviral Agents
  • Cross-Sectional Studies
  • Darunavir
  • Emtricitabine
  • Female
  • HIV Infections
  • Humans
  • Logistic Models
  • Male
  • Middle Aged
  • RNA, Viral
  • Raltegravir Potassium
  • Ritonavir
  • Telomere
  • Tenofovir

Keywords

  • HIV infection
  • aging
  • immunosenescence
  • telomere length
  • viral load


Human T Cell Differentiation Negatively Regulates Telomerase Expression Resulting in Reduced Activation-Induced Proliferation and Survival.


MeSH Terms

  • Adult
  • Cell Differentiation
  • Cell Proliferation
  • Cell Survival
  • Humans
  • T-Lymphocytes
  • Telomerase

Keywords

  • T cell subsets
  • T lymphocytes
  • aging
  • alternative splicing
  • differentiation
  • hTERT
  • proliferation
  • telomerase


Short Communication: Getting Older with HIV: Increasing Frequency of Comorbidities and Polypharmacy in Brazilian HIV Patients.


MeSH Terms

  • Aged
  • Aging
  • Brazil
  • CD4 Lymphocyte Count
  • Cardiovascular Diseases
  • Comorbidity
  • Diabetes Mellitus
  • Female
  • HIV Infections
  • Humans
  • Life Expectancy
  • Male
  • Middle Aged
  • Neoplasms
  • Polypharmacy

Keywords

  • Brazil
  • HIV
  • aging
  • noncommunicable diseases


Gait Speed Decline Is Associated with Hemoglobin A1C, Neurocognitive Impairment, and Black Race in Persons with HIV.


MeSH Terms

  • Adult
  • African Americans
  • Aging
  • CD4 Lymphocyte Count
  • Cohort Studies
  • Female
  • Glycated Hemoglobin A
  • HIV Infections
  • Humans
  • Longitudinal Studies
  • Male
  • Middle Aged
  • Neurocognitive Disorders
  • Odds Ratio
  • RNA, Viral
  • Risk Factors
  • Walking Speed

Keywords

  • aging
  • gait speed
  • hemoglobin A1C
  • neurocognitive impairment


Noncommunicable Diseases Burden and Risk Factors in a Cohort of HIV+ Elderly Patients in Malawi.


MeSH Terms

  • Adult
  • Age Factors
  • Aged
  • Anti-HIV Agents
  • Anti-Retroviral Agents
  • CD4 Lymphocyte Count
  • Comorbidity
  • Cost of Illness
  • Cross-Sectional Studies
  • Diabetes Mellitus
  • Female
  • HIV Infections
  • Humans
  • Hypertension
  • Malawi
  • Male
  • Middle Aged
  • Noncommunicable Diseases
  • Odds Ratio
  • Prevalence
  • Retrospective Studies
  • Risk Factors

Keywords

  • HIV infection
  • Malawi
  • aging
  • noncommunicable diseases


Aging promotes reorganization of the CD4 T cell landscape toward extreme regulatory and effector phenotypes.


MeSH Terms

  • Aging
  • Animals
  • CD4-Positive T-Lymphocytes
  • High-Throughput Nucleotide Sequencing
  • Immunomodulation
  • Mice
  • Phenotype
  • Sequence Analysis, RNA
  • Single-Cell Analysis
  • T-Lymphocyte Subsets


Prevalence of hypertension and cardiovascular risk factors among long-term AIDS survivors: A report from the field.


MeSH Terms

  • Acquired Immunodeficiency Syndrome
  • Adult
  • Anti-Retroviral Agents
  • CD4 Lymphocyte Count
  • Cardiovascular Diseases
  • Diabetes Mellitus
  • Diagnostic Screening Programs
  • Female
  • HIV Infections
  • HIV-1
  • Haiti
  • Humans
  • Hypercholesterolemia
  • Hypertension
  • Male
  • Middle Aged
  • Obesity
  • Prevalence
  • Retrospective Studies
  • Risk Factors
  • Smoking
  • Survivors

Keywords

  • HIV
  • aging
  • cardiovascular disease
  • hypertension
  • risk assessment

CD44[править]

Hyaluronan goes to great length.


Keywords

  • aging
  • hyaluronan
  • longevity
  • naked mole rat
  • very high molecular weight hyaluronan


Naked mole-rat very-high-molecular-mass hyaluronan exhibits superior cytoprotective properties.


MeSH Terms

  • Animals
  • Apoptosis
  • Cell Cycle Checkpoints
  • Cell Line
  • Cytoprotection
  • Gene Expression Regulation
  • Gene Knockout Techniques
  • Humans
  • Hyaluronan Receptors
  • Hyaluronic Acid
  • Longevity
  • Mice
  • Mole Rats
  • Molecular Weight
  • Primary Cell Culture
  • Protein Interaction Maps
  • RNA-Seq
  • Signal Transduction
  • Species Specificity
  • Stress, Physiological
  • Tumor Suppressor Protein p53


Maturity-dependent cartilage cell plasticity and sensitivity to external perturbation.


Keywords

  • Aging
  • Articular cartilage
  • Osteoarthritis
  • Plasticity
  • Progenitor cells


Aged Mice Exhibit Severe Exacerbations of Dry Eye Disease with an Amplified Memory Th17 Cell Response.


MeSH Terms

  • Aging
  • Animals
  • Dry Eye Syndromes
  • Female
  • Immunologic Memory
  • Mice
  • Mice, Inbred C57BL
  • Th17 Cells


Chronic circadian misalignment accelerates immune senescence and abbreviates lifespan in mice.


MeSH Terms

  • Animals
  • B-Lymphocytes
  • Cellular Senescence
  • Circadian Rhythm
  • Disease Models, Animal
  • Humans
  • Hyaluronan Receptors
  • Inflammation
  • Jet Lag Syndrome
  • Longevity
  • Mice
  • Programmed Cell Death 1 Receptor
  • Sequence Analysis, RNA
  • T-Lymphocytes


Defective induction of the proteasome associated with T-cell receptor signaling underlies T-cell senescence.


MeSH Terms

  • Animals
  • CD4-Positive T-Lymphocytes
  • Cell Proliferation
  • Cells, Cultured
  • Cellular Senescence
  • Cytokines
  • Hyaluronan Receptors
  • Mice
  • Mice, Inbred C57BL
  • Phenotype
  • Programmed Cell Death 1 Receptor
  • Proteasome Endopeptidase Complex
  • Receptors, Antigen, T-Cell
  • Signal Transduction

Keywords

  • T cell receptor signal
  • T cell senescence
  • aging
  • proteasome

CD47[править]

Aging-associated changes in CD47 arrangement and interaction with thrombospondin-1 on red blood cells visualized by super-resolution imaging.


Keywords

  • CD47
  • aging
  • dSTORM
  • red blood cells
  • thrombospondin-1


CD47 Promotes Age-Associated Deterioration in Angiogenesis, Blood Flow and Glucose Homeostasis.


Keywords

  • CD47
  • aging
  • angiogenesis
  • blood flow
  • endothelial cells
  • glucose homeostasis
  • metabolism
  • self-renewal
  • thrombospondin-1


Unique Spatial Immune Profiling in Pancreatic Ductal Adenocarcinoma with Enrichment of Exhausted and Senescent T Cells and Diffused CD47-SIRPα Expression.


Keywords

  • CD47
  • T cell exhaustion
  • T cell senescence
  • draining lymph nodes
  • macrophage checkpoint
  • neoadjuvant chemotherapy
  • pancreatic ductal adenocarcinoma
  • signal regulatory protein alpha (SIRPα)
  • spatial heterogeneity
  • tumor microenvironment

CD5[править]

Comparative proteomic analysis identifies biomarkers for renal aging.


Keywords

  • NMN
  • biomarkers
  • glutathionylation
  • proteomics
  • renal aging

CD63[править]

Cellular senescence contributes to age-dependent changes in circulating extracellular vesicle cargo and function.


Keywords

  • aging
  • extracellular vesicles
  • microRNA
  • plasma
  • senescence
  • senolytic

CD68[править]

Insulin activates microglia and increases COX-2/IL-1β expression in young but not in aged hippocampus.


Keywords

  • Aging
  • Hippocampus
  • Insulin
  • Memory
  • Microglia
  • Neuroinflammation


Epigenetic modulation of macrophage polarization prevents lumbar disc degeneration.


Keywords

  • DNA methyltransferase 1 (DNMT1)
  • aging
  • lumbar disc degeneration (LDD)
  • macrophage polarization
  • transforming growth factor beta 1 (TGFβ1)


Cellular senescence in recurrent tonsillitis and tonsillar hypertrophy in children.


MeSH Terms

  • Antigens, CD
  • Antigens, Differentiation, Myelomonocytic
  • Cellular Senescence
  • Child
  • Germinal Center
  • Humans
  • Hypertrophy
  • Macrophages
  • Palatine Tonsil
  • Recurrence
  • Tonsillectomy
  • Tonsillitis

Keywords

  • Cellular senescence
  • Recurrent tonsillitis
  • Tonsillar hypertrophy


Ginsenoside Rg1 supplementation clears senescence-associated β-galactosidase in exercising human skeletal muscle.


Keywords

  • Cellular senescence
  • Endurance
  • Ergogenic aid
  • Inflammation
  • Macrophage


Histopathological, immunohistochemical, and molecular studies for determination of wound age and vitality in rats.


MeSH Terms

  • Actins
  • Animals
  • Antigens, CD
  • Antigens, Differentiation, Myelomonocytic
  • Cell Movement
  • Fibroblasts
  • Granulation Tissue
  • Immunohistochemistry
  • Macrophages
  • Models, Animal
  • Neovascularization, Physiologic
  • RNA, Messenger
  • Rats, Wistar
  • Re-Epithelialization
  • Skin
  • Time Factors
  • Transforming Growth Factor beta1
  • Vascular Endothelial Growth Factor A
  • Wound Healing
  • Wounds and Injuries

Keywords

  • TGFb1
  • VEGF
  • gene expression
  • immunohistochemistry
  • wound aging

CD80[править]

The aging common marmoset's immune system: From junior to senior.


MeSH Terms

  • Aging
  • Animals
  • CD4-CD8 Ratio
  • Callithrix
  • Female
  • Flow Cytometry
  • Immune System
  • Longevity
  • Male
  • Models, Animal
  • Sex Factors

Keywords

  • aging
  • common marmoset
  • immune system
  • immunosenescence
  • innate and adaptive immunity
  • sex

CD81[править]

Ovarian aging increases small extracellular vesicle CD81 release in human follicular fluid and influences miRNA profiles.


Keywords

  • extracellular vesicles
  • follicular fluid
  • microRNAs
  • reproductive aging


Older Adults with Physical Frailty and Sarcopenia Show Increased Levels of Circulating Small Extracellular Vesicles with a Specific Mitochondrial Signature.


Keywords

  • aging
  • biomarkers
  • exosomes
  • mitochondrial dynamics
  • mitochondrial quality control
  • mitochondrial-derived vesicles (MDVs)
  • mitochondrial-lysosomal axis
  • mitophagy


Increased production of functional small extracellular vesicles in senescent endothelial cells.


Keywords

  • endothelium
  • exosomes
  • extracellular vesicles
  • senescence

CDA[править]

Cumulative Dis/Advantage and Health Pattern in Late Life: A Comparison between Genders and Welfare State Regimes.


MeSH Terms

  • Aged
  • Aged, 80 and over
  • China
  • Cross-Sectional Studies
  • England
  • Female
  • Health Behavior
  • Health Status Disparities
  • Humans
  • Longevity
  • Male
  • Mexico
  • Middle Aged
  • Regression Analysis
  • Self Report
  • Sex Factors
  • Social Class
  • Social Welfare
  • United States

Keywords

  • Cumulative dis/advantage
  • cross-national study
  • health retirement study
  • welfare state theory


Does numerical similarity alter age-related distractibility in working memory?


MeSH Terms

  • Adult
  • Aged
  • Aging
  • Alpha Rhythm
  • Attention
  • Evoked Potentials
  • Female
  • Healthy Volunteers
  • Humans
  • Male
  • Memory, Short-Term
  • Young Adult

CDC20[править]

Premature aging syndrome showing random chromosome number instabilities with CDC20 mutation.


Keywords

  • Cdc20 proteins
  • M phase cell cycle checkpoints
  • aging
  • chromosomal instability
  • chromosome segregation
  • genomic instability
  • premature

CDC25A[править]

Babam2 Regulates Cell Cycle Progression and Pluripotency in Mouse Embryonic Stem Cells as Revealed by Induced DNA Damage.


Keywords

  • Babam2
  • DNA damage
  • cell cycle
  • embryonic stem cells
  • pluripotency
  • senescence

CDC42[править]

Effects of age-dependent changes in cell size on endothelial cell proliferation and senescence through YAP1.


MeSH Terms

  • Adaptor Proteins, Signal Transducing
  • Adult
  • Aging
  • Animals
  • Cell Cycle Proteins
  • Cell Size
  • Endothelial Cells
  • Female
  • Humans
  • Male
  • Mice, Inbred C57BL
  • Middle Aged
  • Neovascularization, Physiologic
  • Primary Cell Culture
  • Transcription Factors
  • cdc42 GTP-Binding Protein

Keywords

  • aging
  • angiogenesis
  • cell proliferation
  • cell size
  • senescence

CDH1[править]

Cdc6 as a novel target in cancer: Oncogenic potential, senescence and subcellular localisation.


Keywords

  • Cdc6
  • cytoplasmic Cdc6
  • pancreatic cancer
  • senescence
  • subcellular localisation

CDK1[править]

MicroRNAomic Transcriptomic Analysis Reveal Deregulation of Clustered Cellular Functions in Human Mesenchymal Stem Cells During in Vitro Passaging.


MeSH Terms

  • CDC2-CDC28 Kinases
  • Cell Differentiation
  • Cell Proliferation
  • Cellular Senescence
  • Cyclin B
  • Gene Expression Regulation, Developmental
  • Humans
  • Mesenchymal Stem Cells
  • MicroRNAs
  • Transcriptome
  • Tumor Suppressor Protein p53
  • Umbilical Cord

Keywords

  • Cell proliferation
  • Cell senescence
  • Cellular ageing
  • Human Mesenchymal stem / stromal cells
  • miRNA-mRNA integration

CDK2[править]

p57 is a master regulator of human adipose derived stem cell quiescence and senescence.


Keywords

  • Human adipose derived stem cells
  • Quiescence
  • Senescence
  • p57(Kip2)

CDK4[править]

Emerging Roles for the [i]INK4a/ARF[/i] ([i]CDKN2A[/i]) Locus in Adipose Tissue: Implications for Obesity and Type 2 Diabetes.


Keywords

  • adipogenesis
  • inflammation
  • insulin sensitivity
  • obesity
  • oxidative activity
  • senescence
  • type 2 diabetes


Guilu Erxian Glue () Inhibits Chemotherapy-Induced Bone Marrow Hematopoietic Stem Cell Senescence in Mice May via p16 -Rb Signaling Pathway.


Keywords

  • Chinese medicine
  • Guilu Erxian Glue
  • bone marrow suppression
  • hematopoietic stem cell senescence
  • p16INK4a

CDK5[править]

Age-related hyperinsulinemia leads to insulin resistance in neurons and cell-cycle-induced senescence.


MeSH Terms

  • Aging
  • Animals
  • Cell Cycle
  • Cell Death
  • Cellular Senescence
  • Cyclin-Dependent Kinase 5
  • Excitatory Postsynaptic Potentials
  • Gene Expression
  • Glycolysis
  • Hexokinase
  • Hyperinsulinism
  • Inhibitory Postsynaptic Potentials
  • Insulin
  • Insulin Resistance
  • Liraglutide
  • Male
  • Maze Learning
  • Metformin
  • Mice
  • Neurons
  • Phosphotransferases
  • Primary Cell Culture
  • Protein-Serine-Threonine Kinases
  • Ubiquitination
  • beta Catenin

CDK6[править]

Saturated Fatty Acids Promote Hepatocytic Senecence through Regulation of miR-34a/Cyclin-Dependent Kinase 6.


Keywords

  • cyclin-dependent kinase 6 (CDK6)
  • high-fat diet (HFD)
  • miR-34a
  • palmitate acid (PA)
  • senescence


Hepatoprotective effects of hydroxysafflor yellow A in D-galactose-treated aging mice.


Keywords

  • D-galactose
  • Hydroxysafflor yellow A
  • Oxidative stress
  • Replicative senescence
  • p16


Anti-cell growth and anti-cancer stem cell activity of the CDK4/6 inhibitor palbociclib in breast cancer cells.


Keywords

  • Breast cancer
  • CDK4
  • Cancer stem cells
  • Palbociclib
  • Senescence


Compromising the constitutive p16 expression sensitizes human neuroblastoma cells to Hsp90 inhibition and promotes premature senescence.


Keywords

  • 17AAG
  • Hsp90
  • cancer
  • p16INK4a
  • senescence
  • tumor suppressor

CDKN1A[править]

Involvement of CDKN1A (p21) in cellular senescence in response to heat and irradiation stress during preimplantation development.


Keywords

  • Cdkn1a
  • Heat stress
  • Irradiation
  • Preimplantation
  • Senescence
  • p21

CDKN2A[править]

Association between Nrf2 and CDKN2A expression in patients with end-stage renal disease: a pilot study.


Keywords

  • CDKN2A
  • Nrf2
  • aging
  • end-stage renal disease
  • inflammation

CDKN2B[править]

Molecular Genetics and Functional Analysis Implicate [i]CDKN2BAS1-CDKN2B[/i] Involvement in POAG Pathogenesis.


Keywords

  • African Americans
  • CDKN2B-AS1
  • Primary open-angle glaucoma (POAG)
  • senescence
  • trabecular meshwork cells

CFI[править]

Psychosocial Resources for Hedonic Balance, Life Satisfaction and Happiness in the Elderly: A Path Analysis.


MeSH Terms

  • Adult
  • Aged
  • Aged, 80 and over
  • Aging
  • Cross-Sectional Studies
  • Female
  • Happiness
  • Health Status
  • Humans
  • Male
  • Personal Satisfaction
  • Quality of Life

Keywords

  • happiness
  • older adults
  • path analysis
  • psychosocial resources
  • subjective well-being


Validity and Reliability of the Flourishing Scale in a Sample of Older Adults in Iran.


MeSH Terms

  • Aged
  • Aging
  • Cross-Sectional Studies
  • Female
  • Geriatric Assessment
  • Health Status Disparities
  • Humans
  • Iran
  • Male
  • Mental Health
  • Psychometrics
  • Reproducibility of Results
  • Surveys and Questionnaires

Keywords

  • aging
  • factor analysis
  • flourishing
  • reliability
  • validity


The decision about retirement: A scale to describe representations and practices of medical doctors and nurses.


Keywords

  • Aging
  • Job satisfaction
  • Retirement
  • Scale


Family versus intimate partners: Estimating who matters more for health in a 20-year longitudinal study.


MeSH Terms

  • Adult
  • Aged
  • Aging
  • Emotions
  • Family Relations
  • Female
  • Health Status
  • Humans
  • Interpersonal Relations
  • Longitudinal Studies
  • Male
  • Middle Aged
  • Sexual Partners
  • United States


Adapting and validating the Rosenberg Self-Esteem Scale for elderly Spanish population.


Keywords

  • aging
  • life span
  • self-esteem
  • structural equation model
  • validity

CFTR[править]

Exercise Physiology Across the Lifespan in Cystic Fibrosis.


Keywords

  • aging
  • cystic fibrosis
  • exercise capacity
  • exercise prescription
  • pediatric


Reduced expression of the Ion channel CFTR contributes to airspace enlargement as a consequence of aging and in response to cigarette smoke in mice.


MeSH Terms

  • Aging
  • Animals
  • Cystic Fibrosis Transmembrane Conductance Regulator
  • Gene Expression
  • Inhalation Exposure
  • Mice
  • Mice, Knockout
  • Pulmonary Emphysema
  • Tobacco Smoke Pollution

Keywords

  • Aging
  • CFTR
  • Emphysema
  • Smoking

CGA[править]

Safety and efficacy of preoperative chemoradiotherapy in fit older patients with intermediate or locally advanced rectal cancer evaluated by comprehensive geriatric assessment: A planned interim analysis of a multicenter, phase II trial.


Keywords

  • Comprehensive geriatric assessment
  • Geriatrics
  • Preoperative chemoradiotherapy
  • Rectal cancer


The Protective Effect of Chlorogenic Acid on Vascular Senescence via the Nrf2/HO-1 Pathway.


Keywords

  • chlorogenic acid
  • heme oxygenase-1
  • nuclear factor erythroid 2-related factor 2
  • vascular senescence


Association between comprehensive geriatric assessment and short-term outcomes among older adult patients with stroke: A nationwide retrospective cohort study using propensity score and instrumental variable methods.


Keywords

  • Comprehensive geriatric assessment
  • Geriatrics
  • Japanese diagnosis procedure combination database
  • Length of stay
  • Mortality
  • Stroke


Interventions to Improve Clinical Outcomes in Older Adults Admitted to a Surgical Service: A Systematic Review and Meta-analysis.


Keywords

  • Aging
  • comprehensive geriatric assessment
  • delirium
  • functional status
  • outcomes
  • surgery


A Computerized Frailty Assessment Tool at Points-of-Care: Development of a Standalone Electronic Comprehensive Geriatric Assessment/Frailty Index (eFI-CGA).


Keywords

  • aging
  • comprehensive geriatric assessment (CGA)
  • electronic assessment tools
  • frailty
  • frailty index
  • healthcare
  • older adults


Allocating patients to geriatric medicine wards in a tertiary university hospital in England: A service evaluation of the Specialist Advice for the Frail Elderly (SAFE) team.


Keywords

  • clinical frailty scale
  • frail older adults
  • geriatrics
  • hospital medicine


Role of Frailty on Risk Stratification in Cardiac Surgery and Procedures.


MeSH Terms

  • Aged
  • Aged, 80 and over
  • Cardiac Surgical Procedures
  • Frail Elderly
  • Frailty
  • Geriatric Assessment
  • Humans
  • Percutaneous Coronary Intervention
  • Risk Assessment
  • Transcatheter Aortic Valve Replacement

Keywords

  • Cardiac surgery
  • Comprehensive geriatric assessment
  • Disability
  • Elderly
  • Frailty
  • Geriatrics
  • Surgical risk scores
  • TAVI


Developing an objective structured clinical examination in comprehensive geriatric assessment - A pilot study.


MeSH Terms

  • Aged
  • Clinical Competence
  • Education, Medical, Graduate
  • Educational Measurement
  • Female
  • Geriatric Assessment
  • Geriatrics
  • Humans
  • Male
  • Pilot Projects
  • United Kingdom

Keywords

  • Comprehensive geriatric assessment
  • development
  • entrustable professional capabilities
  • objective structured clinical examination
  • summative assessment


How do doctors choose treatment for older gynecological cancer patients? A Japanese Gynecologic Oncology Group survey of gynecologic oncologists.


MeSH Terms

  • Aged
  • Aged, 80 and over
  • Comorbidity
  • Female
  • Genital Neoplasms, Female
  • Geriatric Assessment
  • Gynecology
  • Humans
  • Hysterectomy
  • Japan
  • Lymph Node Excision
  • Oncologists
  • Surveys and Questionnaires

Keywords

  • Comprehensive geriatric assessment
  • Elderly
  • Geriatrics
  • Gynecologic cancer


Validation of the Pictorial Fit-Frail Scale in a memory clinic setting.


Keywords

  • aging
  • dementia
  • frail elderly
  • frailty
  • psychometrics


Impact of Resolution of Hyponatremia on Neurocognitive and Motor Performance in Geriatric Patients.


MeSH Terms

  • Activities of Daily Living
  • Aged
  • Aged, 80 and over
  • Aging
  • Cognition
  • Female
  • Geriatrics
  • Humans
  • Hyponatremia
  • Male
  • Mental Status and Dementia Tests
  • Middle Aged
  • Motor Activity
  • Sodium


Health outcome of older hospitalized patients in internal medicine environments evaluated by Identification of Seniors at Risk (ISAR) screening and geriatric assessment.


MeSH Terms

  • Accidental Falls
  • Aged
  • Aged, 80 and over
  • Cohort Studies
  • Emergency Service, Hospital
  • Female
  • Geriatric Assessment
  • Health Status
  • Hospitalization
  • Humans
  • Internal Medicine
  • Length of Stay
  • Male
  • Mass Screening
  • Patient Discharge
  • Risk Assessment

Keywords

  • CGA
  • Cutoff
  • Geriatrics
  • ISAR
  • Internal medicine
  • Older in-patients
  • Risk screening
  • Sensitivity
  • Specificity

CHI3L1[править]

Postsynaptic damage and microglial activation in AD patients could be linked CXCR4/CXCL12 expression levels.


Keywords

  • Aging
  • Alzheimer’s disease
  • Bioinformatics
  • CHI3L1
  • Chitinase
  • NRGN

CHRNA7[править]

Associations between genetic variations and global motion perception.


MeSH Terms

  • Adult
  • Differential Threshold
  • Female
  • Genotype
  • Humans
  • Male
  • Motion Perception
  • Polymorphism, Single Nucleotide
  • Receptors, Nicotinic
  • Sensory Thresholds
  • Young Adult
  • alpha7 Nicotinic Acetylcholine Receptor

Keywords

  • Aging
  • CHRNA7
  • Cholinergic system
  • Coherent motion
  • Genetic variations

CHSY1[править]

Loss of Chondroitin Sulfate Modification Causes Inflammation and Neurodegeneration in [i]skt[/i] Mice.


MeSH Terms

  • Age Factors
  • Animals
  • Apoptosis
  • Chondroitin Sulfates
  • Female
  • Glucuronosyltransferase
  • Inflammation
  • Male
  • Mice
  • Mice, Inbred C57BL
  • Mice, Knockout
  • Multifunctional Enzymes
  • Mutation
  • N-Acetylgalactosaminyltransferases
  • Neurodegenerative Diseases
  • Neurons
  • Protein Processing, Post-Translational
  • Proteins
  • Retinal Degeneration

Keywords

  • aging
  • chondroitin sulfate synthase
  • hippocampus
  • inflammation
  • mouse
  • myeloid cells
  • neurodegeneration
  • retina
  • retinal pigment epithelium
  • subretinal space

CISD2[править]

CISD2 Attenuates Inflammation and Regulates Microglia Polarization in EOC Microglial Cells-As a Potential Therapeutic Target for Neurodegenerative Dementia.


Keywords

  • CISD2
  • M1/M2 microglia polarization
  • aging
  • anti-inflammatory effects
  • neurodegenerative disease and dementia

CIT[править]

Effect of sex on aging-related decline of dopamine transporter in healthy subjects.


Keywords

  • 123I-FP-CIT
  • Aging
  • Dopamine plasma membrane transport proteins
  • SPECT
  • Sex


The Relationship Between the Striatal Dopaminergic Neuronal and Cognitive Function With Aging.


Keywords

  • SPECT
  • Wechsler Adult Intelligence Scale
  • aging
  • cognitive function
  • dopamine transporter
  • verbal function

CLEC3B[править]

CLEC3B p.S106G Mutant in a Caucasian Population of Successful Neurological Aging.


Keywords 

         APOE
       

         CLEC3B
  • Aging
  • Human genetics
  • Human health

COL1A1[править]

Remodeling process in bone of aged rats in response to resistance training.


MeSH Terms

  • Age Factors
  • Aging
  • Animals
  • Bone Remodeling
  • Gene Expression Regulation
  • Male
  • Physical Conditioning, Animal
  • RNA, Messenger
  • Random Allocation
  • Rats
  • Rats, Wistar
  • Resistance Training

Keywords

  • Aging
  • Bone homeostasis
  • Function
  • Resistance training

COL3A1[править]

Different expression of Defensin-B gene in the endometrium of mares of different age during the breeding season.


MeSH Terms

  • Aging
  • Animals
  • Breeding
  • Defensins
  • Endometrium
  • Female
  • Fibrosis
  • Gene Expression
  • Horses
  • Inflammation
  • Reverse Transcriptase Polymerase Chain Reaction

Keywords

  • Defensin-β
  • Endometrium
  • Gene expression
  • Immune-modulation
  • Mare

COMT[править]

The geriatric pain experience in mice: intact cutaneous thresholds but altered responses to tonic and chronic pain.


MeSH Terms

  • Acetone
  • Aging
  • Animals
  • Behavior
  • Biogenic Monoamines
  • Capsaicin
  • Chronic Pain
  • Disease Models, Animal
  • Male
  • Mice, Inbred C57BL
  • Peripheral Nerve Injuries
  • Physical Stimulation
  • Prefrontal Cortex
  • Sensory Thresholds

Keywords

  • Geriatric pain
  • Healthy aging
  • Mice
  • Sensory thresholds
  • Supraspinal plasticity
  • Tonic and chronic pain response

COPE[править]

Patterns and characteristics of cognitive functioning in older patients approaching end stage kidney disease, the COPE-study.


Keywords

  • Cognitive function
  • End stage renal disease
  • Geriatric assessment
  • Geriatrics
  • Older patients

CORT[править]

Sex differences in body composition, metabolism-related hormones, and energy homeostasis during aging in Wistar rats.


Keywords

  • aging
  • body composition
  • energy metabolism
  • metabolism-related hormone
  • sex differences


Effects of age and social isolation on murine hippocampal biochemistry and behavior.


Keywords

  • Aging
  • Hippocampus
  • Inflammation
  • Memory
  • Serotonin
  • Social isolation
  • Stress


Interleukin 6 reduces allopregnanolone synthesis in the brain and contributes to age-related cognitive decline in mice.


Keywords

  • Alzheimer’s disease
  • aging
  • cognitive function
  • enzyme regulation
  • inflammation
  • neurosteroid
  • progesterone
  • steroid hormones


Sex- and age-dependent differences in the hormone and drinking responses to water deprivation.


MeSH Terms

  • Age Factors
  • Animals
  • Arginine Vasopressin
  • Behavior, Animal
  • Dehydration
  • Drinking
  • Female
  • Male
  • Rats, Wistar
  • Sex Factors
  • Sodium Chloride
  • Subfornical Organ
  • Water Deprivation

Keywords

  • aging
  • hormonal response
  • sex differences
  • sodium appetite
  • thirst


Ontogeny of the adrenocortical response in an extremely altricial bird.


MeSH Terms

  • Adrenal Glands
  • Aging
  • Animals
  • Corticosterone
  • Female
  • Hypothalamo-Hypophyseal System
  • Male
  • Parrots
  • Restraint, Physical
  • Stress, Physiological

Keywords

  • Venezuela
  • adrenocortical
  • altricial
  • birds
  • corticosterone
  • glucocorticoid
  • hypothalamic-pituitary-adrenal axis
  • ontogeny
  • parrots
  • stress

CP[править]

A Life Course Perspective on Growing Older With Cerebral Palsy.


Keywords

  • aging
  • cerebral palsy
  • midlife
  • neurological disorders
  • neurology
  • qualitative descriptive


The molecular anatomy and functions of the choroid plexus in healthy and diseased brain.


Keywords

  • Aging
  • Alzheimer's disease
  • Choroid plexus
  • Development
  • Multiple sclerosis
  • Neuroprotection


The effects and mechanism of collagen peptide and elastin peptide on skin aging induced by D-galactose combined with ultraviolet radiation.


Keywords

  • Collagen
  • D-galactose
  • Elastin
  • Skin aging
  • Ultraviolet


Model based strategies towards protein A resin lifetime optimization and supervision.


MeSH Terms

  • Algorithms
  • Chromatography
  • Kinetics
  • Least-Squares Analysis
  • Ligands
  • Models, Theoretical
  • Principal Component Analysis
  • Resins, Plant
  • Staphylococcal Protein A
  • Statistics as Topic

Keywords

  • Cleaning procedures
  • Hybrid modeling
  • Multivariate data analysis
  • Protein A chromatography
  • Resin aging
  • Resin lifetime


The influence of age and environmental conditions on supplement intake by beef cattle winter grazing northern mixed-grass rangelands.


MeSH Terms

  • Aging
  • Animal Feed
  • Animal Husbandry
  • Animals
  • Cattle
  • Diet
  • Dietary Supplements
  • Ecosystem
  • Female
  • Poaceae
  • Seasons
  • Weather

Keywords

  • beef cattle
  • cow age
  • environment
  • supplement intake
  • winter grazing


Cyclophosphamide, a cancer chemotherapy drug-induced early onset of reproductive senescence and alterations in reproductive performance and their prevention in mice.


Keywords

  • Cyclophosphamide
  • Decalepis hamiltonii
  • premature ovarian failure
  • reproductive performance
  • reproductive senescence
  • uterus


Asymptomatic [i]Clostridium perfringens[/i] Inhabitation in Intestine Can Cause Inflammation, Apoptosis, and Disorders in Brain.


MeSH Terms

  • Aging
  • Animals
  • Apoptosis
  • Asymptomatic Infections
  • Brain
  • Brain Diseases
  • Clostridium Infections
  • Clostridium perfringens
  • Disease Models, Animal
  • Feces
  • Food Microbiology
  • Gene Expression
  • Humans
  • Inflammation
  • Intestines
  • Liver
  • Male
  • Mice
  • Mice, Inbred C57BL
  • Organ Size
  • Oxidative Stress
  • Risk Factors
  • Spleen

Keywords

  • Clostridium perfringens
  • brain damage
  • brain disorder
  • gut microbiota


The Role of the Clinical Pharmacist in the Management of People Living with HIV in the Modern Antiretroviral Era.


MeSH Terms

  • Aged
  • Aged, 80 and over
  • Anti-Retroviral Agents
  • Disease Management
  • Disease Transmission, Infectious
  • Female
  • HIV Infections
  • Humans
  • Male
  • Medication Adherence
  • Middle Aged
  • Pharmacists
  • Professional Role
  • Treatment Outcome

Keywords

  • Aging
  • Antiretroviral therapy
  • Clinical pharmacist
  • Comorbidities
  • HIV


A clinically feasible method for the assessment and characterization of pain in patients with chronic pancreatitis.


MeSH Terms

  • Adult
  • Aging
  • Case-Control Studies
  • Cross-Sectional Studies
  • Humans
  • Middle Aged
  • Pain
  • Pain Measurement
  • Pancreatitis, Chronic
  • Sex Factors

Keywords

  • Central sensitization
  • Chronic pancreatitis
  • Nociception
  • Pain


Differences in geometric strength at the contralateral hip between men with hip fracture and non-fractured comparators.


Keywords

  • Aging
  • DXA
  • Fracture prevention
  • Injury/fracture healing
  • Osteoporosis


Factors associated with the number of clinical pharmacy recommendations: findings from an observational study in geriatric inpatients.


Keywords

  • Clinical pharmacy
  • geriatrics
  • inpatients
  • polypharmacy
  • risk stratification


Protection against oxidative stress and anti-aging effect in Drosophila of royal jelly-collagen peptide.


MeSH Terms

  • Aging
  • Amino Acids
  • Animals
  • Body Weight
  • Collagen
  • Drosophila
  • Fatty Acids
  • Feeding Behavior
  • Hydrogen Peroxide
  • Longevity
  • Molecular Weight
  • Oxidative Stress
  • Paraquat

Keywords

  • Anti-aging
  • Antioxidant activity
  • Collagen
  • Drosophila
  • Royal jelly

CPM[править]

Test-Retest Instability of Temporal Summation and Conditioned Pain Modulation Measures in Older Adults.


Keywords

  • Aging
  • Anxiety
  • Conditioned Pain Modulation
  • Pain Catastrophizing
  • Reliability
  • Temporal Summation of Pain


Age does not affect sex effect of conditioned pain modulation of pressure and thermal pain across 2 conditioning stimuli.


Keywords

  • Aging
  • CPM duration
  • Conditioned pain modulation
  • Conditioning stimulus
  • Sex differences
  • Test stimulus


The Decline of Endogenous Pain Modulation With Aging: A Meta-Analysis of Temporal Summation and Conditioned Pain Modulation.


Keywords

  • Aging
  • conditioned pain modulation
  • meta-analysis
  • pain modulation
  • temporal summation

CPNE1[править]

Prevalent intron retention fine-tunes gene expression and contributes to cellular senescence.


Keywords

  • CPNE1
  • U2AF1
  • intron retention
  • senescence
  • splicing factor

CPT1A[править]

Alteration of fatty acid oxidation by increased CPT1A on replicative senescence of placenta-derived mesenchymal stem cells.


Keywords

  • CPT1A
  • Fatty acid
  • Mitochondria
  • Placenta-derived mesenchymal stem cell
  • Senescence

CPT1C[править]

Carnitine palmitoyltransferase 1C reverses cellular senescence of MRC-5 fibroblasts via regulating lipid accumulation and mitochondrial function.


Keywords

  • MRC-5 fibroblasts
  • carnitine palmitoyltransferase 1C (CPT1C)
  • cellular senescence
  • lipidomics
  • mitochondrial function


Carnitine palmitoyltransferase 1C contributes to progressive cellular senescence.


Keywords

  • carnitine palmitoyltransferase 1C
  • metabolic reprogramming
  • mitochondria
  • senescence
  • stable transfection

CPT2[править]

The phytochemical epigallocatechin gallate prolongs the lifespan by improving lipid metabolism, reducing inflammation and oxidative stress in high-fat diet-fed obese rats.


Keywords

  • EGCG
  • free fatty acid
  • high-fat dietary
  • lifespan
  • proteomics
  • transcriptome

CR1[править]

Single Nucleotide Polymorphisms in Alzheimer's Disease Risk Genes Are Associated with Intrinsic Connectivity in Middle Age.


Keywords

  • Aging
  • Alzheimer’s disease
  • middle aged
  • neuroimaging
  • single nucleotide

polymorphism


The whale shark genome reveals how genomic and physiological properties scale with body size.


MeSH Terms

  • Adaptation, Physiological
  • Animals
  • Base Sequence
  • Body Size
  • Genome
  • Genomics
  • Longevity
  • Sharks
  • Temperature

Keywords

  • body size
  • lifespan
  • metabolic rate
  • neural genes
  • whale shark

CRABP2[править]

Preconception resveratrol intake against infertility: Friend or foe?


Keywords

  • aging
  • assisted reproductive technology
  • infertility
  • resveratrol
  • sirtuin

CRBN[править]

Using proteolysis-targeting chimera technology to reduce navitoclax platelet toxicity and improve its senolytic activity.


MeSH Terms

  • Adaptor Proteins, Signal Transducing
  • Aging
  • Aniline Compounds
  • Animals
  • Blood Platelets
  • Cell Line
  • Cellular Senescence
  • Female
  • Humans
  • Male
  • Mice
  • Mice, Transgenic
  • Models, Animal
  • Primary Cell Culture
  • Proteolysis
  • Sulfonamides
  • Ubiquitin-Protein Ligases
  • bcl-X Protein

CRP[править]

Omega-3 supplementation improves isometric strength but not muscle anabolic and catabolic signaling in response to resistance exercise in healthy older adults.


Keywords

  • Muscle wasting
  • aging
  • anabolic resistance
  • inflammation
  • resistance training
  • sarcopenia


Circulating angiopoietin-like protein 2 levels and arterial stiffness in patients receiving maintenance hemodialysis: A cross-sectional study.


Keywords

  • Angiopoietin-like protein (ANGPTL) 2
  • Cardio-ankle vascular index (CAVI)
  • Chronic inflammation
  • Hemodialysis
  • Senescence


Cardiovascular rehabilitation in patients aged 70-year-old or older: benefits on functional capacity, physical activity and metabolic profile in younger [i]vs[/i]. older patients.


Keywords

  • Aging
  • Cardiovascular prevention
  • Exercise-based cardiac rehabilitation


rRT-PCR Results of a Covid-19 Diagnosed Geriatric Patient.


Keywords

  • COVID-19
  • False negative reactions
  • Geriatrics
  • Mass screening
  • Reverse transcriptase polymerase chain reaction
  • SARS-CoV-2
  • Tomography


The Association of Aging Biomarkers, Interstitial Lung Abnormalities, and Mortality.


Keywords

  • aging
  • growth differentiation factor 15
  • idiopathic pulmonary fibrosis
  • interstitial lung abnormalities
  • mortality


A Novel Fortified Dairy Product and Sarcopenia Measures in Sarcopenic Older Adults: A Double-Blind Randomized Controlled Trial.


Keywords

  • Functional food
  • aging
  • beta-hydroxy beta-methylbutyrate
  • muscle strength
  • sarcopenia
  • vitamin D


Age-Related Colonic Mucosal Microbiome Community Shifts in Monkeys.


Keywords

  • Aging
  • Microbial co-occurrences
  • Mucosal microbiome
  • Systemic inflammation


The relationship between frailty and serum alpha klotho levels in geriatric patients.


Keywords

  • Aging
  • Biomarkers
  • Frailty syndrome
  • Geriatric syndrome
  • Sarcopenia


ZMPSTE24 Is Associated with Elevated Inflammation and Progerin mRNA.


Keywords

  • ZMPSTE24
  • aging
  • inflammation
  • lamin A/C
  • progerin


Cultural and life style practices associated with low inflammatory physiology in Japanese adults.


Keywords

  • Aging
  • Bathing
  • C-reactive protein
  • Diet
  • Inflammation
  • Interleukin-6
  • Japan
  • Tea


Moderate- to high intensity aerobic and resistance exercise reduces peripheral blood regulatory cell populations in older adults with rheumatoid arthritis.


Keywords

  • Aging
  • Breg cells
  • Exercise
  • IL-10
  • Rheumatoid arthritis
  • T cells
  • Treg cells


PTSD and the klotho longevity gene: Evaluation of longitudinal effects on inflammation via DNA methylation.


Keywords

  • Accelerated aging
  • Inflammation
  • Klotho
  • Methylation
  • PTSD


Bereavement is associated with reduced systemic inflammation: C-reactive protein before and after widowhood.


Keywords

  • Aging
  • Bereavement
  • C-reactive protein
  • Health
  • Inflammation
  • Widowhood


The Impact of Age on the Prevalence of Sarcopenic Obesity in Bariatric Surgery Candidates.


Keywords

  • Aging
  • Bariatric surgery
  • Elderly
  • Obesity
  • Sarcopenia


Intake of dietary advanced glycation end products influences inflammatory markers, immune phenotypes, and antiradical capacity of healthy elderly in a little-studied population.


Keywords

  • CRP
  • advanced glycationed end products
  • aging
  • dAGE
  • immunity
  • inflammation


Intentional Switching Between Bimanual Coordination Patterns in Older Adults: Is It Mediated by Inhibition Processes?


Keywords

  • Stroop task
  • aging
  • bimanual coordination
  • inhibition
  • mediation analysis
  • switching


Shorter Telomere Length in Peripheral Blood Leukocytes Is Associated with Post-Traumatic Chronic Osteomyelitis.


Keywords

  • aging
  • post-traumatic chronic osteomyelitis
  • telomere


Risk Factors of Progression to Frailty: Findings from the Singapore Longitudinal Ageing Study.


MeSH Terms

  • Aged
  • Aged, 80 and over
  • Aging
  • Disease Progression
  • Female
  • Frail Elderly
  • Frailty
  • Geriatric Assessment
  • Humans
  • Independent Living
  • Longitudinal Studies
  • Male
  • Nutrition Assessment
  • Nutritional Status
  • Physical Examination
  • Risk Factors
  • Singapore
  • Socioeconomic Factors

Keywords

  • Frailty
  • longitudinal
  • risk factors
  • transition


Physical Function and Strength in Relation to Inflammation in Older Adults with Obesity and Increased Cardiometabolic Risk.


MeSH Terms

  • Aged
  • Aging
  • Cardiovascular Diseases
  • Female
  • Humans
  • Inflammation
  • Male
  • Muscle Strength
  • Obesity
  • Physical Exertion

Keywords

  • Inflammation
  • cardiovascular disease risk factors
  • obesity
  • physical activity
  • physical function


Key diagnostic characteristics of fever of unknown origin in Japanese patients: a prospective multicentre study.


MeSH Terms

  • Adult
  • Aged
  • Aged, 80 and over
  • Female
  • Fever of Unknown Origin
  • Humans
  • Japan
  • Male
  • Middle Aged
  • Prospective Studies
  • Young Adult

Keywords

  • Japan
  • aging population
  • elderly
  • erythrocyte sedimentation rate
  • fever of unknown origin
  • prospective studies


Decrease in Serum Vitamin D Level of Older Patients with Fatigue.


MeSH Terms

  • Aged
  • Cohort Studies
  • Fatigue
  • Female
  • Humans
  • Male
  • Middle Aged
  • Vitamin D
  • Vitamin D Deficiency

Keywords

  • aging
  • mental fatigue
  • older
  • physical fatigue
  • sex differences
  • vitamin D


The Association between Frailty Indicators and Blood-Based Biomarkers in Early-Old Community Dwellers of Thailand.


MeSH Terms

  • Aged
  • Aged, 80 and over
  • Biomarkers
  • C-Reactive Protein
  • CD4-CD8 Ratio
  • Cross-Sectional Studies
  • Female
  • Frail Elderly
  • Frailty
  • Humans
  • Independent Living
  • Interleukin-6
  • Male
  • Middle Aged
  • Thailand

Keywords

  • C-reactive protein
  • Thailand
  • aging
  • cross-sectional study
  • frailty
  • frailty biomarkers
  • fried’s phenotypes
  • interleukin-6


Associations of C-reactive protein and homocysteine concentrations with the impairment of intrinsic capacity domains over a 5-year follow-up among community-dwelling older adults at risk of cognitive decline (MAPT Study).


MeSH Terms

  • Activities of Daily Living
  • Aged
  • Biomarkers
  • Body Mass Index
  • C-Reactive Protein
  • Cognitive Dysfunction
  • Depression
  • Female
  • Follow-Up Studies
  • Geriatric Assessment
  • Hand Strength
  • Homocysteine
  • Humans
  • Independent Living
  • Inflammation
  • Male
  • Mobility Limitation
  • Neuropsychological Tests
  • Prospective Studies
  • Risk Factors
  • Time Factors

Keywords

  • Aging
  • C-reactive protein
  • Homocysteine
  • Inflammation
  • Intrinsic capacity
  • Older adults


Longitudinal analysis of loneliness and inflammation at older ages: English longitudinal study of ageing.


MeSH Terms

  • Age Factors
  • Aged
  • Aged, 80 and over
  • Aging
  • C-Reactive Protein
  • England
  • Female
  • Ferritins
  • Fibrinogen
  • Humans
  • Inflammation
  • Loneliness
  • Longitudinal Studies
  • Male
  • Middle Aged

Keywords

  • C-reactive protein
  • Ferritin
  • Fibrinogen
  • Inflammation
  • Loneliness


The cortisol burden in elderly subjects with metabolic syndrome and its association with low-grade inflammation.


MeSH Terms

  • Aged
  • Aged, 80 and over
  • Echocardiography
  • Female
  • Humans
  • Hydrocortisone
  • Inflammation
  • Male
  • Metabolic Syndrome

Keywords

  • Aging
  • Cortisol
  • Inflammation
  • Metabolic syndrome


Recurrent circadian fasting (RCF) improves blood pressure, biomarkers of cardiometabolic risk and regulates inflammation in men.


MeSH Terms

  • Adult
  • Biomarkers
  • Blood Pressure
  • C-Reactive Protein
  • Cardiovascular Diseases
  • Circadian Rhythm
  • Diet
  • Energy Intake
  • Fasting
  • Heart Rate
  • Humans
  • Inflammation
  • Male
  • Metabolic Diseases
  • Middle Aged
  • Nutritional Physiological Phenomena
  • Regression Analysis
  • Risk Factors
  • Young Adult

Keywords

  • Aging
  • Health benefits
  • Inflammation
  • Recurrent fasting


Characteristics of patients with rheumatoid arthritis undergoing primary total joint replacement: A 14-year trend analysis (2004-2017).


MeSH Terms

  • Adult
  • Aged
  • Antirheumatic Agents
  • Arthritis, Rheumatoid
  • Arthroplasty, Replacement
  • Arthroplasty, Replacement, Knee
  • Biological Products
  • Drug Utilization
  • Female
  • Humans
  • Japan
  • Male
  • Middle Aged
  • Postoperative Complications

Keywords

  • C-reactive protein
  • Rheumatoid arthritis
  • aging
  • arthroplasty
  • drug therapy

CS[править]

Acute effect of bodyweight-based strength training on blood pressure of hypertensive older adults: A randomized crossover clinical trial.


Keywords

  • Exercise
  • aging
  • hypertension
  • hypotension
  • resistance training


Particle growth with photochemical age from new particle formation to haze in the winter of Beijing, China.


Keywords

  • Condensation sink
  • Haze
  • New particle formation
  • Photochemical aging
  • Pollution evolution


Effect of aging on stabilization of Cd and Ni by biochars and enzyme activities in a historically contaminated alkaline agricultural soil simulated with wet-dry and freeze-thaw cycling.


Keywords

  • Accelerated aging
  • Biochar
  • Cadmium
  • Enzyme activity
  • Heavy metal stabilization
  • Soil remediation


Cockayne syndrome proteins CSA and CSB maintain mitochondrial homeostasis through NAD signaling.


Keywords

  • AMPK
  • Cockayne syndrome
  • NAD+
  • accelerated ageing
  • aging
  • mitochondrial maintenance
  • mitophagy


Vision Impairment and Participation in Cognitively Stimulating Activities: The Health ABC Study.


Keywords

  • Cognition
  • Cognitive Aging
  • Sensory
  • Vision loss


Suspension training vs. traditional resistance training: effects on muscle mass, strength and functional performance in older adults.


Keywords

  • Aging
  • Functionality
  • Instability resistance training
  • Muscle hypertrophy
  • TRX training


Generational Differences in the 10-year Incidence of Impaired Contrast Sensitivity.


Keywords

  • Aging
  • Birth Cohort Effect
  • Contrast Sensitivity
  • Epidemiology
  • Visual Function


Inducible aging in Hydra oligactis implicates sexual reproduction, loss of stem cells, and genome maintenance as major pathways.


Keywords

  • Aging
  • Cold-sensitive
  • DNA repair
  • Gametogenesis
  • Hydra oligactis
  • Transcriptome


Noradrenergic Responsiveness Supports Selective Attention across the Adult Lifespan.


MeSH Terms

  • Adult
  • Aged
  • Aging
  • Attention
  • Brain Waves
  • Cortical Synchronization
  • Humans
  • Male
  • Norepinephrine
  • Reflex, Pupillary

Keywords

  • cognitive aging
  • locus coeruleus
  • noradrenaline
  • norepinephrine
  • rhythmic neural activity
  • selective attention


Cellular senescence: from anti-cancer weapon to anti-aging target.


MeSH Terms

  • Aging
  • Animals
  • Antineoplastic Agents
  • Breast Neoplasms
  • Cell Proliferation
  • Cell Transformation, Neoplastic
  • Cellular Senescence
  • Cyclin-Dependent Kinases
  • Drug Discovery
  • Female
  • Humans
  • Piperazines
  • Protein Kinase Inhibitors
  • Pyridines

Keywords

  • cancer
  • cellular senescence
  • healthy aging
  • pro-senescence cancer therapy
  • senolytic therapies


Extra-mitochondrial citrate synthase initiates calcium oscillation and suppresses age-dependent sperm dysfunction.


MeSH Terms

  • Aging
  • Animals
  • Calcium Signaling
  • Citrate (si)-Synthase
  • Citric Acid Cycle
  • Female
  • Infertility, Male
  • Male
  • Metabolome
  • Mice
  • Ovum
  • Spermatozoa


Pathogenesis of chronic obstructive pulmonary disease (COPD) induced by cigarette smoke.


Keywords

  • Airway inflammation
  • autophagy
  • cellular senescence
  • chronic obstructive pulmonary disease (COPD)
  • necroptosis
  • oxidative stress


Possible Role of Amyloid Cross-Seeding in Evolvability and Neurodegenerative Disease.


MeSH Terms

  • Aging
  • Amyloidogenic Proteins
  • Animals
  • Biological Evolution
  • Brain
  • Female
  • Humans
  • Inheritance Patterns
  • Models, Neurological
  • Neurodegenerative Diseases
  • Pregnancy
  • Stress, Physiological

Keywords

  • Alzheimer’s disease
  • Parkinson’s disease
  • amyloid cascade hypothesis
  • amyloidogenic proteins
  • antimicrobial protection model
  • cross-seeding
  • evolvability hypothesis


Targeting p16-induced senescence prevents cigarette smoke-induced emphysema by promoting IGF1/Akt1 signaling in mice.


MeSH Terms

  • Alveolar Epithelial Cells
  • Animals
  • Cell Proliferation
  • Cellular Senescence
  • Cyclin-Dependent Kinase Inhibitor p16
  • Cytokines
  • Emphysema
  • Insulin-Like Growth Factor I
  • Lung
  • Mice, Inbred C57BL
  • Models, Biological
  • Promoter Regions, Genetic
  • Proto-Oncogene Proteins c-akt
  • Pulmonary Disease, Chronic Obstructive
  • RNA, Messenger
  • Signal Transduction
  • Smoking

Keywords

  • Molecular biology
  • Senescence
  • Stem cells

CSF1R[править]

CSF1R inhibitor PLX5622 and environmental enrichment additively improve metabolic outcomes in middle-aged female mice.


Keywords

  • CSF1R
  • adipose
  • aging
  • environmental enrichment
  • microglia


Modulation of Microglia by Voluntary Exercise or CSF1R Inhibition Prevents Age-Related Loss of Functional Motor Units.


MeSH Terms

  • Aging
  • Animals
  • Cell Line
  • Databases, Genetic
  • Humans
  • Induced Pluripotent Stem Cells
  • Macrophages
  • Male
  • Mice
  • Mice, Inbred C57BL
  • Microglia
  • Motor Neurons
  • Muscle, Skeletal
  • Neuromuscular Junction
  • Neuronal Plasticity
  • Physical Conditioning, Animal
  • RNA-Seq
  • Receptors, Granulocyte-Macrophage Colony-Stimulating Factor
  • Spinal Cord

Keywords

  • CSF1R inhibition
  • aging
  • exercise
  • innervation
  • microglia
  • motor unit
  • neuroinflammation
  • neuromuscular junction
  • neuromuscular system
  • spinal cord

CTCF[править]

New targeted approaches for epigenetic age predictions.


Keywords

  • Aging
  • Amplicon sequencing
  • Blood
  • Buccal swabs
  • CTCF
  • DNA methylation
  • Droplet digital PCR
  • Epigenetic
  • Human

CTH[править]

Anterior Cingulate Structure and Perfusion is Associated with Cerebrospinal Fluid Tau among Cognitively Normal Older Adult APOEɛ4 Carriers.


Keywords

  • APOE
  • Aging
  • Alzheimer’s disease
  • cerebral blood flow
  • cognition
  • cognitive decline
  • grey matter
  • magnetic resonance imaging
  • tau proteins

CTLA4[править]

Horticultural Therapy Reduces Biomarkers of Immunosenescence and Inflammaging in Community-Dwelling Older Adults: A Feasibility Pilot Randomized Controlled Trial.


Keywords

  • CTLA-4
  • Geroscience
  • IL-6
  • Immunosenescence
  • Inflammaging

CTRL[править]

Aging reduces the maximal level of peripheral fatigue tolerable and impairs exercise capacity.


Keywords

  • aging
  • critical torque
  • exercise performance
  • group III/IV muscle afferents
  • neuromuscular fatigue


miR-146a Plasma Levels Are Not Altered in Alzheimer's Disease but Correlate With Age and Illness Severity.


Keywords

  • Alzheimer’s disease
  • aging
  • blood
  • miR-146a
  • microRNA
  • plasma


Centrally-mediated regulation of peripheral fatigue during knee extensor exercise and consequences on the force-duration relationship in older men.


Keywords

  • Aging
  • critical torque
  • group III/IV muscle afferents

CTSA[править]

A CTSA-based consultation service to advance research on special and underserved populations.


Keywords

  • faculty development
  • geriatrics
  • grant review
  • grant studio
  • pediatrics
  • peer review
  • research consultation service
  • special populations
  • underrepresented minorities

CTSB[править]

Myocardial cathepsin D is downregulated in sudden cardiac death.


MeSH Terms

  • Adult
  • Aged
  • Aged, 80 and over
  • Aging
  • Cathepsin D
  • Death, Sudden, Cardiac
  • Down-Regulation
  • Female
  • Humans
  • Male
  • Middle Aged
  • Myocardium
  • Substrate Specificity

CX3CL1[править]

Two forms of CX3CL1 display differential activity and rescue cognitive deficits in CX3CL1 knockout mice.


Keywords

  • Aging
  • CX3CL1
  • Cognition
  • Fractalkine
  • Long-term potentiation
  • Microglia
  • Neurodegeneration
  • Neurogenesis
  • Neuroinflammation

CX3CR1[править]

Monocytes present age-related changes in phospholipid concentration and decreased energy metabolism.


Keywords

  • DNA methylation
  • aging
  • glucose metabolism
  • monocytes
  • phosphatidylcholines
  • transcriptome


Muscle Injury Induces Postoperative Cognitive Dysfunction.


MeSH Terms

  • Aging
  • Animals
  • Brain
  • Brain-Derived Neurotrophic Factor
  • CX3C Chemokine Receptor 1
  • Cytokines
  • Disease Models, Animal
  • Hippocampus
  • Humans
  • Male
  • Mice
  • Microglia
  • Muscle, Skeletal
  • Nerve Growth Factor
  • Postoperative Cognitive Complications
  • Postoperative Complications

CXCL1[править]

Contusion spinal cord injury upregulates p53 protein expression in rat soleus muscle at multiple timepoints but not key senescence cytokines.


Keywords

  • SASP
  • cytokines
  • inflammation
  • paralysis
  • senescence
  • spinal cord injury


Systemic Inflammation and the Increased Risk of Inflamm-Aging and Age-Associated Diseases in People Living With HIV on Long Term Suppressive Antiretroviral Therapy.


MeSH Terms

  • Adult
  • Aging
  • Anti-HIV Agents
  • Antiretroviral Therapy, Highly Active
  • Biomarkers
  • CD4 Lymphocyte Count
  • Computational Biology
  • Cross-Sectional Studies
  • Disease Susceptibility
  • Duration of Therapy
  • Female
  • HIV Infections
  • Humans
  • Inflammation
  • Male
  • Metabolome
  • Metabolomics
  • Middle Aged
  • Proteomics
  • Telomere Homeostasis
  • Viral Load

Keywords

  • HIV
  • India
  • LMIC (lower middle income country)
  • inflammation markers
  • long term antiretroviral therapy

CXCL10[править]

Age-related decline of interferon-gamma responses in macrophage impairs satellite cell proliferation and regeneration.


Keywords

  • Aging
  • CXCL10
  • IFN-γ
  • Macrophage
  • Muscle regeneration
  • Single-cell RNA sequence

CXCL11[править]

Endothelial cells under therapy-induced senescence secrete CXCL11, which increases aggressiveness of breast cancer cells.


Keywords

  • CXCL11
  • Endothelial cells
  • Therapy-induced senescence
  • Tumor microenvironment

CXCL12[править]

Co-option of Neutrophil Fates by Tissue Environments.


Keywords

  • angiogenesis
  • immune heterogeneity
  • immune niche
  • innate immunity
  • neutrophil lifespan
  • neutrophils
  • single-cell analysis
  • tissue-resident cells


Heme oxygenase-1 deficiency triggers exhaustion of hematopoietic stem cells.


Keywords

  • aging
  • bone marrow
  • cxcl12-abudant reticular cells
  • endothelial cells
  • niche


Global Transcriptomic Profiling of the Bone Marrow Stromal Microenvironment during Postnatal Development, Aging, and Inflammation.


MeSH Terms

  • Aging
  • Animals
  • Bone Marrow
  • Bone Marrow Cells
  • Cell Differentiation
  • Cells, Cultured
  • Cellular Microenvironment
  • Chemokine CXCL12
  • Embryonic Development
  • Endothelial Cells
  • Gene Expression Profiling
  • Hematopoiesis
  • Hematopoietic Stem Cells
  • Inflammation
  • Male
  • Mesenchymal Stem Cells
  • Mice
  • Mice, Inbred C57BL
  • Stem Cell Niche
  • Transcriptome

Keywords

  • aging
  • bone marrow microenvironment
  • hematopoietic stem cells
  • inflammation
  • niches
  • stromal cells
  • transcriptomics

CXCL13[править]

RNA-seq data from C-X-C chemokine receptor type 5 (CXCR5) gene knockout aged mice with retinal degeneration phenotype.


Keywords

  • CXCR5
  • FastQC
  • RNA-Seq
  • aging
  • choroid
  • mice
  • retina
  • retinal degeneration

CXCL14[править]

Identification of genes associated with endometrial cell aging.


Keywords

  • CXCL12
  • CXCL14
  • IL17RB
  • endometrial cell aging
  • infertility
  • quantitative

immunohistochemistry

CXCL8[править]

Cerebrovascular Senescence Is Associated With Tau Pathology in Alzheimer's Disease.


Keywords

  • Alzheimer's disease
  • endothelial senescence
  • gene expression
  • neurofibrillary tangles
  • plasma biomarkers
  • tau pathology
  • vascular dysfunction

CXCL9[править]

CXCL9 and CXCL10 display an age-dependent profile in Chagas patients: a cohort study of aging in Bambui, Brazil.


MeSH Terms

  • Aged
  • Aged, 80 and over
  • Aging
  • Biomarkers
  • Brazil
  • Chagas Disease
  • Chemokine CXCL10
  • Chemokine CXCL9
  • Cohort Studies
  • Electrocardiography
  • Female
  • Humans
  • Male
  • Middle Aged
  • Trypanosoma cruzi

Keywords

  • Chagas disease
  • Chemokines
  • Cohort
  • Cytokines
  • Immune biomarkers

CXCR2[править]

CXCL5-CXCR2 signaling is a senescence-associated secretory phenotype in preimplantation embryos.


Keywords

  • CXCL5
  • CXCR2
  • SASP
  • aging
  • infertility
  • preimplantation embryo


Senescence in Wound Repair: Emerging Strategies to Target Chronic Healing Wounds.


Keywords

  • ageing
  • diabetes
  • senescence
  • senolytics
  • wound healing

CXCR3[править]

Senescent hepatocytes enhance natural killer cell activity via the CXCL-10/CXCR3 axis.


Keywords

  • chemokine
  • hepatocyte
  • natural killer cell
  • senescence

CXCR4[править]

Aging-Related Reduced Expression of CXCR4 on Bone Marrow Mesenchymal Stromal Cells Contributes to Hematopoietic Stem and Progenitor Cell Defects.


Keywords

  • Aging
  • CXCR4 and ROS
  • HSPC
  • MSC


Transfer of a human gene variant associated with exceptional longevity improves cardiac function in obese type 2 diabetic mice through induction of the SDF-1/CXCR4 signalling pathway.


Keywords

  • BPIFB4
  • Cardiomyopathy
  • Diabetes
  • Gene therapy
  • Longevity


Stromal Cell-Derived Factor 1 Protects Brain Vascular Endothelial Cells from Radiation-Induced Brain Damage.


MeSH Terms

  • Animals
  • Blood Vessels
  • Brain
  • Cell Line
  • Cellular Senescence
  • Chemokine CXCL12
  • Cranial Irradiation
  • Disease Models, Animal
  • Down-Regulation
  • Endothelial Cells
  • Female
  • Gene Expression Regulation
  • Humans
  • Lipopeptides
  • Mice
  • Receptors, CXCR4
  • Signal Transduction

Keywords

  • CXCR4
  • SDF-1
  • brain disorder
  • endothelial dysfunction
  • ionizing radiation
  • senescence

CYP11B1[править]

Intratumoral heterogeneity of the tumor cells based on in situ cortisol excess in cortisol-producing adenomas; ∼An association among morphometry, genotype and cellular senescence∼.


Keywords

  • CYP11B1
  • CYP17A
  • Cellular senescence
  • Compact and clear cells
  • Cortisol-producing adenoma
  • PRKACA

CYP1A1[править]

Genome-wide scan identified genetic variants associated with skin aging in a Chinese female population.


MeSH Terms

  • Adult
  • Aged
  • Aged, 80 and over
  • Asian Continental Ancestry Group
  • Cheek
  • Cohort Studies
  • Cytochrome P-450 CYP1A1
  • European Continental Ancestry Group
  • Female
  • Genome-Wide Association Study
  • Humans
  • Middle Aged
  • Polymorphism, Single Nucleotide
  • Risk Factors
  • Skin Aging
  • Skin Pigmentation

Keywords

  • Candidate SNPs
  • Chinese Han females
  • GWAS
  • Skin aging

CYP26B1[править]

Increased Retinoic Acid Catabolism in Olfactory Sensory Neurons Activates Dormant Tissue-Specific Stem Cells and Accelerates Age-Related Metaplasia.


MeSH Terms

  • Aging
  • Animals
  • Female
  • Isotretinoin
  • Male
  • Metaplasia
  • Mice
  • Neural Stem Cells
  • Neurogenesis
  • Olfactory Mucosa
  • Olfactory Receptor Neurons
  • Retinoic Acid 4-Hydroxylase

Keywords

  • aging
  • inositol-1,4,5-triphosphate
  • metaplasia
  • olfactory epithelium
  • retinoic acid
  • stem cells

CYP2C19[править]

Physiologically Based Pharmacokinetic Approach Can Successfully Predict Pharmacokinetics of Citalopram in Different Patient Populations.


Keywords

  • citalopram
  • genetic polymorphism
  • geriatrics
  • physiologically based pharmacokinetic modeling


Longitudinal exposure of English primary care patients to pharmacogenomic drugs: An analysis to inform design of pre-emptive pharmacogenomic testing.


MeSH Terms

  • Aged
  • Aged, 80 and over
  • Aging
  • Cytochrome P-450 CYP2C19
  • Cytochrome P-450 CYP2D6
  • Drug Prescriptions
  • Female
  • Humans
  • Liver-Specific Organic Anion Transporter 1
  • Longitudinal Studies
  • Male
  • Middle Aged
  • Pharmaceutical Preparations
  • Pharmacogenomic Testing
  • Precision Medicine
  • Primary Health Care
  • United Kingdom

Keywords

  • clinical pharmacology
  • general practice
  • pharmacogenomics

CYP2E1[править]

DNA methylation and histone acetylation changes to cytochrome P450 2E1 regulation in normal aging and impact on rates of drug metabolism in the liver.


Keywords

  • Aging
  • Cyp2e1
  • DNA methylation
  • Drug metabolism
  • Histone acetylation
  • Pharmacokinetics

CYP7A1[править]

Age-associated changes of cytochrome P450 and related phase-2 gene/proteins in livers of rats.


Keywords

  • Aging
  • Cytochrome P450’s
  • Nuclear receptors
  • Ontogeny
  • Rat liver
  • mRNA/protein expression

DBI[править]

Quantifying cumulative anticholinergic and sedative drug load among US Medicare Beneficiaries.


Keywords

  • aging
  • cholinergic antagonists
  • drug burden index
  • drug utilization
  • hypnotics and sedatives
  • inappropriate prescribing
  • pharmacoepidemiology


Drug Burden Index and Cognitive and Physical Function in Aged Care Residents: A Longitudinal Study.


Keywords

  • Cognitive function
  • anti-muscarinics
  • benzodiazepines
  • geriatrics
  • longitudinal
  • mobility impairment
  • physical function
  • polypharmacy


Using the Drug Burden Index to identify older adults at highest risk for medication-related falls.


Keywords

  • Accidental falls
  • Aging
  • Health services
  • Medication
  • Medication therapy management


Impact of STEADI-Rx: A Community Pharmacy-Based Fall Prevention Intervention.


Keywords

  • aging
  • community pharmacy
  • falls
  • health services
  • medication

DBP[править]

Do baseline blood pressure and type of exercise influence level of reduction induced by training in hypertensive older adults? A meta-analysis of controlled trials.


Keywords

  • Aged
  • Aging
  • Exercise
  • Exercise therapy
  • High blood pressure
  • Hypertension
  • Resistance training


Attenuated aortic blood pressure responses to metaboreflex activation in older adults with dynapenia.


Keywords

  • Aging
  • Diastolic pressure
  • Handgrip strength
  • Post-exercise muscle ischemia
  • Walking performance


The Effect of Blood Pressure on Cognitive Performance. An 8-Year Follow-Up of the Tromsø Study, Comprising People Aged 45-74 Years.


Keywords

  • aging
  • blood pressure
  • cognitive performance
  • dementia
  • sex differences


Low Diastolic Blood Pressure and Cognitive Decline in Korean Elderly People: The Korean Longitudinal Study on Cognitive Aging and Dementia.


Keywords

  • Cognition
  • Diastolic blood pressure
  • Senility


Diastolic Blood Pressure Is Associated With Regional White Matter Lesion Load: The Northern Manhattan Study.


MeSH Terms

  • Aged
  • Arterial Pressure
  • Blood Pressure
  • Brain
  • Cohort Studies
  • Diastole
  • Female
  • Frontal Lobe
  • Humans
  • Hypertension
  • Linear Models
  • Magnetic Resonance Imaging
  • Male
  • Middle Aged
  • Organ Size
  • Parietal Lobe
  • Prospective Studies
  • Systole
  • Temporal Lobe
  • White Matter

Keywords

  • American Heart Association
  • blood pressure
  • cerebrovascular disease
  • cognitive aging
  • white matter


Orthostatic Hypotension and Novel Blood Pressure Associated Gene Variants in Older Adults: Data From the TILDA Study.


Keywords

  • Aging
  • Blood pressure
  • Cardiovascular
  • Genetics
  • Single-nucleotide polymorphism


Blood pressure and hypertension prevalence among oldest-old in China for 16 year: based on CLHLS.


MeSH Terms

  • Aged, 80 and over
  • Blood Pressure
  • Blood Pressure Determination
  • China
  • Female
  • Health Surveys
  • Humans
  • Hypertension
  • Longevity
  • Longitudinal Studies
  • Male
  • Prevalence

Keywords

  • Blood pressure
  • Epidemiology
  • Hypertension
  • Oldest-old
  • Prevalence


The age-related blood pressure trajectories from young-old adults to centenarians: A cohort study.


MeSH Terms

  • Age Factors
  • Aged
  • Aged, 80 and over
  • Aging
  • Blood Pressure
  • Cohort Studies
  • Female
  • Humans
  • Male
  • Middle Aged

Keywords

  • Antihypertensive therapy
  • Birth cohort effect
  • Blood pressure
  • Cohort study
  • Heart disease
  • Survival

DCC[править]

X Chromosome Domain Architecture Regulates Caenorhabditis elegans Lifespan but Not Dosage Compensation.


MeSH Terms

  • Adenosine Triphosphatases
  • Animals
  • Caenorhabditis elegans
  • Caenorhabditis elegans Proteins
  • DNA-Binding Proteins
  • Dosage Compensation, Genetic
  • Gene Expression Regulation
  • Longevity
  • Multiprotein Complexes
  • X Chromosome

Keywords

  • X chromosome dosage compensation
  • aging
  • condensin
  • gene expression
  • higher-order chromosome structure
  • lifespan
  • proteotoxic stress
  • topologically associating domains

DCN[править]

Decorin inhibits the insulin-like growth factor I signaling in bone marrow mesenchymal stem cells of aged humans.


Keywords

  • IGF-I
  • aging
  • bone marrow mesenchymal stem cell
  • osteoporosis
  • small leucine-rich proteoglycan

DCX[править]

GSK-3β activation accelerates early-stage consumption of Hippocampal Neurogenesis in senescent mice.


Keywords

  • Adult hippocampal neurogenesis
  • Glycogen synthase kinase-3β
  • Senescence


Doublecortin and IGF-1R protein levels are reduced in spite of unchanged DNA methylation in the hippocampus of aged rats.


Keywords

  • Aging
  • DNA methylation
  • Doublecortin
  • Hippocampus
  • IGF-1R
  • mGluR5

DDB1[править]

DCAF1 regulates Treg senescence via the ROS axis during immunological aging.


Keywords

  • Aging
  • Cellular senescence
  • Immunology
  • Inflammatory bowel disease
  • T cells

DDC[править]

N-Acetyl Cysteine Attenuates the Sarcopenia and Muscle Apoptosis Induced by Chronic Liver Disease.


MeSH Terms

  • Acetylcysteine
  • Aging
  • Animals
  • Apoptosis
  • Disease Models, Animal
  • End Stage Liver Disease
  • Humans
  • Mice
  • Muscle Fibers, Skeletal
  • Muscular Atrophy
  • Oxidative Stress
  • Pyridines
  • Sarcopenia

Keywords

  • Sarcopenia
  • UPP oxidative stress
  • apoptosis
  • chronic liver disease
  • hepatotoxin.

DDO[править]

New insights on the influence of free d-aspartate metabolism in the mammalian brain during prenatal and postnatal life.


Keywords

  • Brain aging
  • Cell death
  • L-Glutamate
  • NMDA receptors
  • d-Aspartate
  • d-Aspartate oxidase

DDT[править]

Prognostic Value of a Test of Central Auditory Function in Conversion from Mild Cognitive Impairment to Dementia.


Keywords

  • Aging
  • Alzheimer’s disease
  • Auditory processing
  • Cognition
  • Dichotic Digits Test


Uptake kinetics of four hydrophobic organic pollutants in the earthworm Eisenia andrei in aged laboratory-contaminated natural soils.


MeSH Terms

  • Animals
  • DDT
  • Hexachlorocyclohexane
  • Hydrophobic and Hydrophilic Interactions
  • Kinetics
  • Oligochaeta
  • Polychlorinated Biphenyls
  • Pyrenes
  • Soil Pollutants

Keywords

  • Aging
  • BAFs
  • Bioaccumulation
  • HOCs
  • Laboratory-contaminated soils


Adult exposure to insecticides causes persistent behavioral and neurochemical alterations in zebrafish.


Keywords

  • Aging
  • Anxiety-related behavior
  • DDT
  • Neurobehavioral toxicology
  • Zebrafish


Second generation effects of larval metal pollutant exposure on reproduction, longevity and insecticide tolerance in the major malaria vector Anopheles arabiensis (Diptera: Culicidae).


MeSH Terms

  • Animals
  • Anopheles
  • Drug Resistance
  • Female
  • Fertility
  • Insecticides
  • Larva
  • Male
  • Metals
  • Reproduction
  • Water Pollutants

Keywords

  • Anopheles arabiensis
  • Insecticide resistance
  • Longevity
  • Transgenerational effects


Protective effect of Pedro-Ximénez must against p,p'-DDE-induced liver damages in aged Mus spretus mice.


MeSH Terms

  • Aging
  • Animals
  • Antioxidants
  • Chemical and Drug Induced Liver Injury
  • Dichlorodiphenyl Dichloroethylene
  • Down-Regulation
  • Liver
  • Male
  • Mice
  • Oxidative Stress
  • Pesticides
  • Plant Extracts
  • Polyphenols
  • Transcriptome
  • Up-Regulation
  • Vitis

Keywords

  • Aging
  • Hepatoprotection
  • Mus spretus
  • Organochlorine
  • Oxidative damage
  • Pedro-ximénez grape must
  • Transcriptional analysis
  • p,p'-DDE


Low-dose endosulfan inhibits proliferation and induces senescence and pro-inflammatory cytokine production in human lymphocytes, preferentially impacting cytotoxic cells.


MeSH Terms

  • Adult
  • B-Lymphocytes
  • Cell Proliferation
  • Cells, Cultured
  • Cellular Senescence
  • Cytokines
  • Dose-Response Relationship, Drug
  • Endosulfan
  • Female
  • Healthy Volunteers
  • Humans
  • Inflammation Mediators
  • Insecticides
  • Killer Cells, Natural
  • Male
  • Primary Cell Culture
  • T-Lymphocytes, Cytotoxic
  • Young Adult

Keywords

  • Endosulfan
  • Immunosenescence
  • NK cells
  • PBMC
  • cytotoxic cells
  • interferon
  • organochlorine pesticide
  • senescence

DKC1[править]

Successful liver transplantation in short telomere syndromes without bone marrow failure due to DKC1 mutation.


Keywords

  • DKC1
  • cell death: senescence
  • cirrhosis
  • hepatopulmonary syndrome
  • liver transplantation
  • short telomere syndromes

DLD[править]

A preliminary study of cerebral blood flow, aging and dementia in people with Down syndrome.


Keywords

  • Alzheimer's disease
  • Down syndrome
  • aging
  • cerebral blood flow
  • neuroimaging

DLGAP2[править]

Cross-Species Analyses Identify Dlgap2 as a Regulator of Age-Related Cognitive Decline and Alzheimer's Dementia.


Keywords

  • Alzheimer’s
  • Diversity Outbred
  • Dlgap2
  • GWAS
  • aging
  • cognition
  • genetic diversity
  • resilience
  • spines
  • susceptibility
  • translational

DLX5[править]

Inhibition of microRNA-27b-3p relieves osteoarthritis pain via regulation of KDM4B-dependent DLX5.


Keywords

  • adipogenic differentiation
  • cell senescence
  • distal-less homeobox 5
  • lysine demethylase 4B
  • mesenchymal stem cells
  • microRNA-27b-3p
  • osteoarthritis pain
  • osteogenic differentiation

DMD[править]

Aldehyde dehydrogenases contribute to skeletal muscle homeostasis in healthy, aging, and Duchenne muscular dystrophy patients.


Keywords

  • Aging
  • Aldehyde dehydrogenase
  • Dog model
  • Duchenne muscular dystrophy
  • Human
  • Myogenic
  • Non-human primate
  • Skeletal muscle


Life expectancy at birth in Duchenne muscular dystrophy: a systematic review and meta-analysis.


MeSH Terms

  • Female
  • Humans
  • Life Expectancy
  • Male
  • Muscular Dystrophy, Duchenne
  • Parturition
  • Pregnancy
  • Prognosis
  • Quality of Life
  • Respiration, Artificial
  • Survival

Keywords

  • Mechanical ventilation
  • Mortality
  • Prognosis
  • Survival


Renal dysfunction can occur in advanced-stage Duchenne muscular dystrophy.


MeSH Terms

  • Adolescent
  • Adult
  • Aging
  • Child
  • Child, Preschool
  • Cystatin C
  • Disease Progression
  • Female
  • Heart Diseases
  • Heart Function Tests
  • Humans
  • Kidney Diseases
  • Kidney Function Tests
  • Male
  • Muscular Dystrophy, Duchenne
  • Risk Factors
  • Young Adult

Keywords

  • Duchenne muscular dystrophy
  • advanced stage
  • cystatin C
  • ejection fraction
  • fractional shortening
  • renal dysfunction

DNAJB9[править]

DNAJB9 Inhibits p53-Dependent Oncogene-Induced Senescence and Induces Cell Transformation.


Keywords

  • DNAJB9
  • RAS
  • p53
  • senescence
  • transformation

DNMT1[править]

DNA Methyltransferase 1 (DNMT1) Function Is Implicated in the Age-Related Loss of Cortical Interneurons.


Keywords

  • DNA methylation
  • GABA
  • aging
  • cerebral cortex
  • inhibitory interneurons
  • proteostasis
  • synapse
  • transcriptional control

DNMT3A[править]

Epigenetic regulation of miR-29a/miR-30c/DNMT3A axis controls SOD2 and mitochondrial oxidative stress in human mesenchymal stem cells.


Keywords

  • Cellular senescence
  • DNMT3A
  • Human mesenchymal stem cells
  • Mitochondrial oxidative stress
  • SOD2
  • microRNAs


Collagens and DNA methyltransferases in mare endometrosis.


MeSH Terms

  • Aging
  • Animals
  • Collagen
  • DNA (Cytosine-5-)-Methyltransferases
  • DNA Methylation
  • Endometritis
  • Endometrium
  • Female
  • Fibrosis
  • Horse Diseases
  • Horses
  • RNA, Messenger

Keywords

  • DNA methylation
  • collagen
  • endometrium
  • epigenetic
  • fibrosis
  • mare


Age-related clonal haemopoiesis is associated with increased epigenetic age.


MeSH Terms

  • Aged
  • Aged, 80 and over
  • Aging
  • Epigenesis, Genetic
  • Female
  • Hematopoiesis
  • Humans
  • Longitudinal Studies
  • Male
  • Risk Factors
  • Scotland

DNMT3L[править]

Transient DNMT3L Expression Reinforces Chromatin Surveillance to Halt Senescence Progression in Mouse Embryonic Fibroblast.


Keywords

  • DNA methyltransferase 3-like (DNMT3L)
  • chromatin surveillance
  • epigenetics
  • polycomb repressive complex 2 (PRC2)
  • senescence
  • transposable element (TE)

DOCK11[править]

[Immunosenescence: The Forefront of Infection and Trophic Control].


MeSH Terms

  • Aging
  • Animals
  • B-Lymphocytes
  • Cytokinesis
  • Gene Expression
  • Guanine Nucleotide Exchange Factors
  • Humans
  • Immunoglobulin M
  • Immunosenescence
  • Mice
  • Nutritional Status
  • Streptococcus pneumoniae

Keywords

  • B-1a B cell
  • dedicator of cytokinesis 11
  • immunosenescence

DPP4[править]

Age-Dependent Assessment of Genes Involved in Cellular Senescence, Telomere, and Mitochondrial Pathways in Human Lung Tissue of Smokers, COPD, and IPF: Associations With SARS-CoV-2 COVID-19 ACE2-TMPRSS2-Furin-DPP4 Axis.


Keywords

  • DNA damage
  • aging
  • cellular senescence
  • chronic obstructive pulmonary diseases
  • idiopathic pulmonary fibrosis
  • mitochondria
  • smokers
  • telomere


Dipeptidyl peptidase-4 inhibition improves endothelial senescence by activating AMPK/SIRT1/Nrf2 signaling pathway.


Keywords

  • Aging
  • Dipeptidyl peptidase-4
  • Endothelium
  • Oxidative stress
  • Vascular


Molecular crosstalk between Y5 receptor and neuropeptide Y drives liver cancer.


Keywords

  • Aging
  • Cancer
  • Hepatology

DPP6[править]

A novel structure associated with aging is augmented in the DPP6-KO mouse brain.


Keywords

  • Aging dementia
  • Alzheimer’s disease
  • DPP6
  • Presynaptic terminals

DPYSL2[править]

Alcohol drinking exacerbates neural and behavioral pathology in the 3xTg-AD mouse model of Alzheimer's disease.


MeSH Terms

  • Alcohol Drinking
  • Alzheimer Disease
  • Amyloid beta-Protein Precursor
  • Animals
  • Behavior, Animal
  • Brain
  • Disease Models, Animal
  • Mice, Transgenic
  • tau Proteins

Keywords

  • Aging
  • Amyloid beta
  • Ethanol
  • GSK
  • Immunohistochemistry
  • Morris Water Maze
  • Prepulse inhibition
  • Self-administration
  • Tau pathology
  • Transgenic mouse model

DRD1[править]

Impact of dopamine-related genetic variants on physical activity in old age - a cohort study.


MeSH Terms

  • Aged
  • Aged, 80 and over
  • Aging
  • Cohort Studies
  • Exercise
  • Humans
  • Receptors, Dopamine
  • Sedentary Behavior
  • Sweden

Keywords

  • Accelerometery
  • Aging
  • Dopamine
  • Genes
  • Physical activity
  • Sedentary behaviour

DRD2[править]

Cortical thickness mediates the relationship between DRD2 C957T polymorphism and executive function across the adult lifespan.


Keywords

  • Aging
  • Cortical thickness
  • DRD2
  • Dopamine
  • Executive function


The relationship of age and DRD2 polymorphisms to frontostriatal brain activity and working memory performance.


MeSH Terms

  • Aging
  • Brain
  • Humans
  • Memory, Short-Term
  • Polymorphism, Genetic
  • Receptors, Dopamine D2

Keywords

  • Aging
  • C957T
  • DRD2
  • Dopamine
  • Working memory
  • fMRI

DSPP[править]

Effects of [i]p[/i]-Cresol on Senescence, Survival, Inflammation, and Odontoblast Differentiation in Canine Dental Pulp Stem Cells.


Keywords

  • aged teeth
  • apoptosis
  • dental pulp stem cells
  • differentiation
  • pulp regeneration
  • senescence

DST[править]

Ancestral germen/soma distinction in microbes: Expanding the disposable soma theory of aging to all unicellular lineages.


MeSH Terms

  • Aging
  • Animals
  • Biological Evolution
  • DNA Replication
  • Humans
  • Phylogeny

Keywords

  • Aging
  • Asymmetric cell division
  • DNA replication
  • Disposable Soma Theory
  • Epigenetics
  • Evolution
  • Germen/Soma
  • Prokaryotes
  • Protists
  • Rejuvenation
  • Unicellular

DUSP1[править]

miR-1468-3p Promotes Aging-Related Cardiac Fibrosis.


Keywords

  • aging
  • cardiac fibrosis
  • dual-specificity phosphatases
  • extracellular matrix
  • miR-1468-3p
  • microRNA
  • p38
  • senescence

DUSP8[править]

MiR-21-5p/dual-specificity phosphatase 8 signalling mediates the anti-inflammatory effect of haem oxygenase-1 in aged intracerebral haemorrhage rats.


MeSH Terms

  • Aging
  • Animals
  • Antagomirs
  • Anti-Inflammatory Agents
  • Cells, Cultured
  • Cerebral Hemorrhage
  • Dual-Specificity Phosphatases
  • HEK293 Cells
  • Heme Oxygenase-1
  • Hemin
  • Humans
  • Male
  • MicroRNAs
  • Rats
  • Rats, Sprague-Dawley
  • Signal Transduction

Keywords

  • aging
  • dual-specificity phosphatase 8
  • haem oxygenase-1
  • intracerebral haemorrhage
  • microRNA

DUT[править]

Simultaneous liquefaction, saccharification, and fermentation of L-lactic acid using aging paddy rice with hull by an isolated thermotolerant Enterococcus faecalis DUT1805.


Keywords

  • Aging paddy rice with hull (APRH)
  • Corn steep liquor powder (CSLP)
  • High-thermotolerance
  • Lactic acid
  • Saccharification and fermentation (SLSF)
  • Simultaneous liquification

DYRK1A[править]

Altered age-linked regulation of plasma DYRK1A in elderly cognitive complainers (INSIGHT-preAD study) with high brain amyloid load.


Keywords

  • Alzheimer's disease
  • aging
  • blood marker
  • immunometric test

E2F1[править]

Regulation of E2F1 activity via PKA-mediated phosphorylations.


Keywords

  • E2F1
  • PKA
  • cell cycle
  • forskolin
  • proliferation
  • senescence


Astragaloside IV ameliorates radiation-induced senescence via antioxidative mechanism.


Keywords

  • cell signal pathway
  • nerve cells
  • radiation
  • senescence

ECD[править]

Outcome of Descemet Membrane Endothelial Keratoplasty Using Corneas from Donors ≥80 Years of Age.


MeSH Terms

  • Adolescent
  • Adult
  • Aged
  • Aged, 80 and over
  • Aging
  • Cell Count
  • Cornea
  • Descemet Stripping Endothelial Keratoplasty
  • Donor Selection
  • Endothelium, Corneal
  • Female
  • Fuchs' Endothelial Dystrophy
  • Humans
  • Male
  • Middle Aged
  • Retrospective Studies
  • Tissue Donors
  • Treatment Outcome
  • Visual Acuity
  • Young Adult

EDA[править]

Interplay between aging, lung inflammation/remodeling, and fibronectin EDA in lung cancer progression.


Keywords

  • Lung cancer
  • aging
  • fibronectin EDA
  • fibrosis
  • inflammation
  • lewis lung carcinoma
  • metastasis


Arousal Detection in Elderly People from Electrodermal Activity Using Musical Stimuli.


Keywords

  • aging adults
  • arousal
  • electrodermal activity
  • musical genres


The structure of agricultural microplastics (PT, PU and UF) and their sorption capacities for PAHs and PHE derivates under various salinity and oxidation treatments.


MeSH Terms

  • Adsorption
  • Agriculture
  • Ecosystem
  • Environmental Pollutants
  • Hydrogen Peroxide
  • Microplastics
  • Models, Chemical
  • Naphthalenes
  • Organic Chemicals
  • Phenanthrenes
  • Plastics
  • Polycyclic Aromatic Hydrocarbons
  • Polyethylene
  • Polypropylenes
  • Polyurethanes
  • Polyuria
  • Pyrenes
  • Salinity

Keywords

  • Aging
  • Microplastics
  • Polycyclic aromatic hydrocarbons
  • Salinity
  • Sorption

EDARADD[править]

Age prediction in living: Forensic epigenetic age estimation based on blood samples.


MeSH Terms

  • Adolescent
  • Adult
  • Aged
  • Aging
  • Child
  • Child, Preschool
  • CpG Islands
  • Cyclic Nucleotide Phosphodiesterases, Type 4
  • DNA Methylation
  • Edar-Associated Death Domain Protein
  • Fatty Acid Elongases
  • Female
  • Forensic Genetics
  • Humans
  • Infant
  • LIM-Homeodomain Proteins
  • Male
  • Middle Aged
  • Muscle Proteins
  • Polymerase Chain Reaction
  • Transcription Factors
  • Young Adult

Keywords

  • Age the living
  • CpGs
  • DNA methylation age
  • Forensic epigenetics
  • Forensic sciences

EDF1[править]

Silencing of FOREVER YOUNG FLOWER Like Genes from Phalaenopsis Orchids Promotes Flower Senescence and Abscission.


Keywords 

         FOREVER YOUNG FLOWER
       

         Phalaenopsis orchids
  • Abscission
  • Ethylene responses
  • MADS-box gene
  • Senescence

EFS[править]

The aging bladder phenotype is not the direct consequence of bladder aging.


MeSH Terms

  • Adrenergic beta-Agonists
  • Aging
  • Animals
  • Carbachol
  • Cholinergic Agonists
  • Electric Stimulation
  • Female
  • Isoproterenol
  • Male
  • Mice
  • Mucous Membrane
  • Muscle Contraction
  • Myography
  • Phenotype
  • Receptor, Muscarinic M3
  • Receptors, Adrenergic, beta-2
  • Urinary Bladder
  • Urination

Keywords

  • aging
  • control physiology
  • resilience
  • urinary dysfunction

EGF[править]

Acute, exercise-induced alterations in cytokines and chemokines in the blood distinguish physically active and sedentary aging.


Keywords

  • growth factors
  • human aging
  • inflammation
  • physical activity


Proinflammation, profibrosis, and arterial aging.


Keywords

  • aging
  • artery
  • collagen
  • profibrosis
  • proinflammation
  • stiffening


Hinokitiol induces cell death and inhibits epidermal growth factor-induced cell migration and signaling pathways in human cervical adenocarcinoma.


Keywords

  • Autophagy
  • Epidermal growth factor
  • Hinokitiol
  • Senescence
  • c-Jun N-Terminal kinase


Activation of epidermal growth factor receptor signaling mediates cellular senescence induced by certain pro-inflammatory cytokines.


Keywords

  • EGFR
  • HUVEC
  • IMR90
  • Ras signaling
  • pro-inflammatory cytokine
  • senescence


Insulin Signaling in Intestinal Stem and Progenitor Cells as an Important Determinant of Physiological and Metabolic Traits in [i]Drosophila[/i].


Keywords

  • ISC
  • fruit fly
  • insulin signaling pathway
  • lifespan
  • metabolism
  • midgut
  • progenitor cells


Different cellular properties and loss of nuclear signalling of porcine epidermal growth factor receptor with aging.


MeSH Terms

  • Animals
  • ErbB Receptors
  • Signal Transduction
  • Swine

Keywords

  • Aging
  • Cell behaviour
  • EGF
  • EGFR
  • Signalling pathway

EGFR[править]

Type I Collagen Aging Increases Expression and Activation of EGFR and Induces Resistance to Erlotinib in Lung Carcinoma in 3D Matrix Model.


Keywords

  • EGFR
  • Erlotinib
  • Type I collagen
  • aging
  • resistance


Comparative effectiveness and cost-effectiveness of three first-line EGFR-tyrosine kinase inhibitors: Analysis of real-world data in a tertiary hospital in Taiwan.


MeSH Terms

  • Afatinib
  • Aged
  • Carcinoma, Non-Small-Cell Lung
  • Cost-Benefit Analysis
  • Erlotinib Hydrochloride
  • Female
  • Gefitinib
  • Humans
  • Life Expectancy
  • Lung Neoplasms
  • Male
  • Propensity Score
  • Protein Kinase Inhibitors
  • Quality of Life
  • Survival Rate
  • Taiwan
  • Tertiary Care Centers


An Optogenetic Method to Study Signal Transduction in Intestinal Stem Cell Homeostasis.


MeSH Terms

  • Animals
  • Cell Communication
  • Cell Proliferation
  • Cells, Cultured
  • Drosophila Proteins
  • Drosophila melanogaster
  • Gene Expression Regulation
  • Gene Regulatory Networks
  • Homeostasis
  • Intestinal Mucosa
  • Light
  • Longevity
  • Optogenetics
  • Signal Transduction
  • Stem Cells

Keywords

  • Drosophila
  • EGFR
  • Toll
  • optogenetics
  • stem cells


Treatment-Induced Tumor Dormancy through YAP-Mediated Transcriptional Reprogramming of the Apoptotic Pathway.


MeSH Terms

  • Adaptor Proteins, Signal Transducing
  • Animals
  • Apoptosis
  • Cell Cycle Proteins
  • Cell Line, Tumor
  • Cell Proliferation
  • Cell Survival
  • Cellular Senescence
  • Drug Resistance, Neoplasm
  • ErbB Receptors
  • Female
  • Gene Deletion
  • Gene Expression Regulation, Neoplastic
  • Humans
  • Lung Neoplasms
  • MAP Kinase Kinase 1
  • Male
  • Mice
  • Mice, Knockout
  • Mutation
  • Signal Transduction
  • Transcription Factors
  • Transcription, Genetic

Keywords

  • YAP
  • dormancy
  • drug resistance
  • drug tolerance
  • epidermal growth factor receptor
  • lung cancer
  • senescence


Association between EGFR mutation and ageing, history of pneumonia and gastroesophageal reflux disease among patients with advanced lung cancer.


MeSH Terms

  • Adult
  • Aged
  • Aged, 80 and over
  • Aging
  • Case-Control Studies
  • ErbB Receptors
  • Female
  • Gastroesophageal Reflux
  • Humans
  • Lung Neoplasms
  • Male
  • Middle Aged
  • Mutation
  • Pneumonia
  • Republic of Korea
  • Retrospective Studies
  • Risk Factors
  • Young Adult

Keywords

  • Ageing
  • EGFR mutation
  • GERD
  • Lung cancer
  • Pneumonia
  • Risk factors

EHF[править]

Extended high frequency hearing and speech perception implications in adults and children.


Keywords

  • Aging
  • Development
  • Extended high frequency audiometry
  • Otitis media
  • Ototoxicity
  • Speech in noise
  • Speech perception
  • Tinnitus

EIF4E[править]

Transcriptomic evidence that insulin signalling pathway regulates the ageing of subterranean termite castes.


MeSH Terms

  • Aging
  • Animals
  • Insulin
  • Isoptera
  • Molecular Sequence Annotation
  • Signal Transduction
  • Transcriptome

ELF3[править]

High Ambient Temperature Accelerates Leaf Senescence via PHYTOCHROME-INTERACTING FACTOR 4 and 5 in [i]Arabidopsis[/i].


Keywords

  • Arabidopsis
  • PIF4
  • phytochrome
  • senescence
  • temperature

ELOVL2[править]

ELOVL2: Not just a biomarker of aging.


Keywords

  • Aging
  • Macular degeneration
  • Membrane structure
  • Polyunsaturated fatty acids


The lipid elongation enzyme ELOVL2 is a molecular regulator of aging in the retina.


MeSH Terms

  • Aging
  • Animals
  • Cell Line
  • DNA Methylation
  • Decitabine
  • Down-Regulation
  • Fatty Acid Elongases
  • Fatty Acids, Unsaturated
  • Female
  • Humans
  • Macular Degeneration
  • Male
  • Mice
  • Mice, Transgenic
  • Point Mutation
  • Promoter Regions, Genetic
  • Retina
  • Retinal Pigment Epithelium

Keywords

  • DNA methylation
  • ELOVL2
  • PUFA
  • age-related macular degeneration
  • aging
  • retina

EN1[править]

Electrochemically detecting DNA methylation in the EN1 gene promoter: implications for understanding ageing and disease.


Keywords

  • Aging
  • biosensor
  • electrochemistry
  • methylation

ENO1[править]

Reduced expression of enolase-1 correlates with high intracellular glucose levels and increased senescence in cisplatin-resistant ovarian cancer cells.


Keywords

  • ENO1
  • Enolase
  • beta-Gal
  • cisplatin resistance
  • glucose
  • ovarian cancer
  • p21
  • p53
  • senescence

ENTPD7[править]

Inhibition of lung cancer cells and Ras/Raf/MEK/ERK signal transduction by ectonucleoside triphosphate phosphohydrolase-7 (ENTPD7).


MeSH Terms

  • Adult
  • Aged
  • Animals
  • Apoptosis
  • Apyrase
  • Biomarkers
  • Cell Line, Tumor
  • Cell Proliferation
  • Cells, Cultured
  • Female
  • Gene Expression Regulation, Neoplastic
  • Gene Silencing
  • Humans
  • Lung Neoplasms
  • MAP Kinase Signaling System
  • Male
  • Mice
  • Mice, Inbred BALB C
  • Mice, Nude
  • Middle Aged
  • Mitogen-Activated Protein Kinases
  • Plasmids
  • Signal Transduction
  • Survival Analysis
  • raf Kinases
  • ras Proteins

Keywords

  • Ectonucleoside triphosphate phosphohydrolase-7
  • Lung cancer
  • Proliferation
  • Senescence

EPO[править]

Regulation of muscle and metabolic physiology by hypothalamic erythropoietin independently of its peripheral action.


Keywords

  • Aging
  • Brain
  • Erythropoietin
  • Glucose tolerance
  • Hypothalamus
  • Metabolism
  • Muscle
  • Obesity


Red Blood Cell Lifespan Shortening in Patients with Early-Stage Chronic Kidney Disease.


MeSH Terms

  • Anemia
  • Erythrocytes
  • Female
  • Humans
  • Male
  • Middle Aged
  • Renal Insufficiency, Chronic

Keywords

  • Chronic kidney disease
  • Erythropoietin
  • Levitt’s CO breath test
  • Red blood cell lifespan
  • Renal anemia

ERCC1[править]

Chronic Sildenafil Treatment Improves Vasomotor Function in a Mouse Model of Accelerated Aging.


Keywords

  • aging
  • cGMP
  • guanylate cyclase
  • hypertension
  • nitric oxide
  • phosphodiesterase
  • sildenafil
  • vascular dysfunction


Local endothelial DNA repair deficiency causes aging-resembling endothelial-specific dysfunction.


MeSH Terms

  • Age Factors
  • Aging
  • Animals
  • Capillary Permeability
  • Cellular Senescence
  • Cyclin-Dependent Kinase Inhibitor p21
  • DNA Damage
  • DNA Repair
  • DNA-Binding Proteins
  • Endonucleases
  • Endothelial Cells
  • Endothelium, Vascular
  • Mice, Inbred C57BL
  • Mice, Knockout
  • Nitric Oxide
  • Nitric Oxide Synthase Type III
  • Superoxides
  • Vascular Stiffness
  • Vasodilation

Keywords

  • DNA damage
  • aging
  • endothelial dysfunction
  • endothelium-dependent dilation
  • nitric oxide


Tissue specificity of senescent cell accumulation during physiologic and accelerated aging of mice.


Keywords

  • DNA repair
  • ERCC1-XPF
  • aging
  • cellular senescence
  • endogenous DNA damage
  • progeria


Deficiency in the DNA repair protein ERCC1 triggers a link between senescence and apoptosis in human fibroblasts and mouse skin.


Keywords

  • DNA damage repair
  • aging
  • cell death
  • senescence-associated secretory phenotype
  • tumor necrosis factor α

ERF[править]

Angiotensin-Converting Enzyme Gene D/I Polymorphism in Relation to Endothelial Function and Endothelial-Released Factors in Chinese Women.


Keywords

  • ACE D/I gene polymorphism
  • Chinese women
  • aging
  • endothelial function
  • endothelial-released factors
  • menopause


Projections of Ambient Temperature- and Air Pollution-Related Mortality Burden Under Combined Climate Change and Population Aging Scenarios: a Review.


Keywords

  • Air pollution
  • Climate change
  • Mortality
  • Population aging
  • Projection
  • Temperature


Exome Sequencing Analysis Identifies Rare Variants in [i]ATM[/i] and [i]RPL8[/i] That Are Associated With Shorter Telomere Length.


Keywords

  • ATM
  • RPL8
  • aging
  • meta-analysis
  • telomere
  • whole exome sequencing

ERG[править]

Effect of age and sex on neurodevelopment and neurodegeneration in the healthy eye: Longitudinal functional and structural study in the Long-Evans rat.


Keywords

  • Aging
  • Electroretinography
  • Neurodegeneration
  • Neurodevelopment
  • Optical coherence tomography
  • Retina
  • Sex


Mice With a Combined Deficiency of Superoxide Dismutase 1 (Sod1), DJ-1 (Park7), and Parkin (Prkn) Develop Spontaneous Retinal Degeneration With Aging.


MeSH Terms

  • Aging
  • Animals
  • Biomarkers
  • Electroretinography
  • Enzyme-Linked Immunosorbent Assay
  • Immunohistochemistry
  • Malondialdehyde
  • Mice
  • Mice, Inbred C57BL
  • Mice, Knockout
  • Microscopy, Electron, Transmission
  • Mitochondria
  • Oxidative Stress
  • Protein Deglycase DJ-1
  • Retina
  • Retinal Degeneration
  • Retinal Pigment Epithelium
  • Superoxide Dismutase-1
  • Tomography, Optical Coherence
  • Ubiquitin-Protein Ligases

ESPL1[править]

Identification and genomic analysis of pedigrees with exceptional longevity identifies candidate rare variants.


Keywords

  • Genomics
  • Longevity
  • Pedigree
  • Rare variant sharing
  • Utah population database

ETS1[править]

The transcription factor ETS1 promotes apoptosis resistance of senescent cholangiocytes by epigenetically up-regulating the apoptosis suppressor BCL2L1.


MeSH Terms

  • ATP Binding Cassette Transporter, Subfamily B
  • Animals
  • Apoptosis
  • Cellular Senescence
  • Hepatocytes
  • Humans
  • Lipopolysaccharides
  • Liver
  • Mice
  • Proto-Oncogene Protein c-ets-1
  • Transcription Factors
  • bcl-X Protein

Keywords

  • BCL2 like 1 (BCL2L1)
  • apoptosis
  • cholangiocyte
  • chromatin modification
  • epigenetics
  • gene expression
  • primary sclerosing cholangitis (PSC)
  • senescence
  • transcription factor

EVL[править]

Health Years in Total: A New Health Objective Function for Cost-Effectiveness Analysis.


MeSH Terms

  • Cost-Benefit Analysis
  • Health Care Costs
  • Health Status
  • Health Status Indicators
  • Humans
  • Life Expectancy
  • Quality of Life
  • Quality-Adjusted Life Years
  • Time Factors

Keywords

  • cost-effectiveness
  • equal value of life
  • health years in total
  • quality-adjusted life-year
  • thresholds

EZH2[править]

Linking gene expression and phenotypic changes in the developmental and evolutionary origins of osteosclerosis in the ribs of bowhead whales (Balaena mysticetus).


Keywords

  • Cetacea
  • aging
  • bone
  • hyperostosis
  • osteoblasts
  • whales


EZH2 is involved in vulnerability to neuroinflammation and depression-like behaviors induced by chronic stress in different aged mice.


Keywords

  • Aging
  • CUMS
  • Cytokines
  • Depresion
  • EZH2
  • Microglia


A positive feedback loop between EZH2 and NOX4 regulates nucleus pulposus cell senescence in age-related intervertebral disc degeneration.


Keywords

  • Epigenetic histone modification
  • Intervertebral disc degeneration
  • Nucleus pulposus cell senescence
  • Wnt/β-catenin signaling pathway


Perinatal exposure to bisphenol A impacts in the mammary gland morphology of adult Mongolian gerbils.


MeSH Terms

  • Actins
  • Aging
  • Animals
  • Benzhydryl Compounds
  • Cell Proliferation
  • Collagen
  • Enhancer of Zeste Homolog 2 Protein
  • Female
  • Gerbillinae
  • Histones
  • Mammary Glands, Animal
  • Phenols
  • Pregnancy
  • Prenatal Exposure Delayed Effects

Keywords

  • BPA
  • EZH2
  • Environment pollutant
  • Estrogen
  • Morphologic alterations
  • Phospho-histone-h3

F2[править]

Environmental risk assessment of glufosinate-resistant soybean by pollen-mediated gene flow under field conditions in the region of the genetic origin.


Keywords

  • Glufosinate resistance
  • Relative fitness
  • Seed longevity
  • Transgene flow
  • Weed risk


Gestational arsenite exposure augments hepatic tumors of C3H mice by promoting senescence in F1 and F2 offspring via different pathways.


Keywords

  • Arsenic
  • Liver
  • Multigenerational Effect
  • SASP
  • Senescence
  • Tumor


Familial Longevity is Associated with an Attenuated Thyroidal Response to Recombinant Human Thyroid Stimulating Hormone.


Keywords

  • Thyroid
  • longevity
  • recombinant human TSH
  • responsivity


Conclusions from a behavioral aging study on male and female F2 hybrid mice on age-related behavior, buoyancy in water-based tests, and an ethical method to assess lifespan.


MeSH Terms

  • Adiposity
  • Aging
  • Animals
  • Exploratory Behavior
  • Female
  • Male
  • Memory
  • Mice, Inbred BALB C
  • Mice, Inbred C57BL
  • Swimming

Keywords

  • F2 hybrid mice
  • aging
  • exploratory activity
  • sex comparison
  • water-based behavioral tests


In utero exposure to acetaminophen and ibuprofen leads to intergenerational accelerated reproductive aging in female mice.


MeSH Terms

  • Acetaminophen
  • Aging
  • Animals
  • Animals, Newborn
  • Cell Proliferation
  • Female
  • Fertility
  • Forkhead Box Protein O3
  • Germ Cells
  • Ibuprofen
  • Luteolysis
  • Mice
  • Ovary
  • Pregnancy
  • Prenatal Exposure Delayed Effects
  • Proto-Oncogene Proteins c-akt
  • Reproduction
  • Signal Transduction

Keywords

  • Infertility
  • Oogenesis
  • Risk factors

F3[править]

A Comprehensive Analysis of Age and Gender Effects in European Portuguese Oral Vowels.


Keywords

  • Acoustic
  • Aging voice
  • European Portuguese
  • Oral vowel


Prenatal exposure to an environmentally relevant phthalate mixture accelerates biomarkers of reproductive aging in a multiple and transgenerational manner in female mice.


Keywords

  • cyclicity
  • hormone
  • mixture
  • ovary
  • phthalates
  • reproductive aging
  • transgenerational


Combining Frontal Transcranial Direct Current Stimulation With Walking Rehabilitation to Enhance Mobility and Executive Function: A Pilot Clinical Trial.


Keywords

  • Aging
  • cognition
  • rehabilitation
  • transcranial direct current stimulation
  • walking


Multigenerational exposure to TiO nanoparticles in soil stimulates stress resistance and longevity of survived C. elegans via activating insulin/IGF-like signaling.


MeSH Terms

  • Animals
  • Caenorhabditis elegans
  • Caenorhabditis elegans Proteins
  • Insulin
  • Longevity
  • Nanoparticles
  • Oxidative Stress
  • Soil
  • Titanium

Keywords

  • Insulin/IGF-like signaling
  • Longevity
  • Multigenerational toxicity
  • Nanomaterial
  • Soil nematode


Co-expression network analysis identified hub genes critical to triglyceride and free fatty acid metabolism as key regulators of age-related vascular dysfunction in mice.


MeSH Terms

  • Aging
  • Animals
  • Fatty Acids, Nonesterified
  • Gene Expression Profiling
  • Gene Expression Regulation
  • Gene Regulatory Networks
  • Lipid Metabolism
  • Mice
  • Microarray Analysis
  • Signal Transduction
  • Triglycerides
  • Vascular Diseases

Keywords

  • aging
  • co-expression network
  • hub gene
  • module
  • mouse
  • vascular dysfunction

F5[править]

Methylation signatures in peripheral blood are associated with marked age acceleration and disease progression in patients with primary sclerosing cholangitis.


Keywords

  • ALP, alkaline phosphatase
  • ALT, alanine aminotransferase
  • Aging
  • BMI, body mass index
  • DNAm, DNA methylation
  • ELF, enhanced liver fibrosis
  • FDR, false discovery rate
  • GGT, gamma-glutamyltransferase
  • IBD, inflammatory bowel disease
  • IL, interleukin
  • LOXL2, lysyl oxidase-like-2
  • NASH, non-alcoholic steatohepatitis
  • PSC, primary sclerosing cholangitis
  • SMA, smooth muscle actin
  • UDCA, ursodeoxycholic acid
  • biomarker
  • inflammatory bowel disease
  • primary sclerosing cholangitis
  • prognosis
  • ursodeoxycholic acid


Fermentation of Blackberry with [i]L. plantarum[/i] JBMI F5 Enhance the Protection Effect on UVB-Mediated Photoaging in Human Foreskin Fibroblast and Hairless Mice through Regulation of MAPK/NF-κB Signaling.


MeSH Terms

  • Animals
  • Cell Line
  • Cell Survival
  • Female
  • Fermentation
  • Fibroblasts
  • Foreskin
  • Fruit
  • Lactobacillus plantarum
  • Male
  • Mice
  • Mice, Hairless
  • Plant Extracts
  • Rubus
  • Skin Aging
  • Ultraviolet Rays

Keywords

  • Lactobacillus plantarum
  • MMPs
  • fermented blackberry
  • photoaging
  • skin aging
  • type I procollagen

F7[править]

The Pattern of Mu Rhythm Modulation During Emotional Destination Memory: Comparison Between Mild Cognitive Impairment Patients and Healthy Controls.


MeSH Terms

  • Aged
  • Aging
  • Cognitive Dysfunction
  • Electroencephalography
  • Emotions
  • Female
  • Frontal Lobe
  • Humans
  • Male
  • Memory
  • Neurophysiological Monitoring
  • Neuropsychological Tests
  • Task Performance and Analysis
  • Temporal Lobe

Keywords

  • Emotional destination memory
  • Mu suppression
  • fronto-temporal
  • mild cognitive impairment
  • mirror neurons

FAAH[править]

Endocannabinoid genetic variation enhances vulnerability to THC reward in adolescent female mice.


MeSH Terms

  • Aging
  • Amidohydrolases
  • Animals
  • Axons
  • Choice Behavior
  • Dronabinol
  • Endocannabinoids
  • Female
  • Genetic Variation
  • Male
  • Mice, Inbred C57BL
  • Nerve Net
  • Nucleus Accumbens
  • Polymorphism, Single Nucleotide
  • Receptor, Cannabinoid, CB1
  • Reward
  • Tyrosine 3-Monooxygenase
  • Ventral Tegmental Area

FABP3[править]

FABP3-mediated membrane lipid saturation alters fluidity and induces ER stress in skeletal muscle with aging.


MeSH Terms

  • Aging
  • Animals
  • Cell Line
  • Endoplasmic Reticulum Stress
  • Eukaryotic Initiation Factor-2
  • Fatty Acid Binding Protein 3
  • Female
  • Gene Knockdown Techniques
  • Lipidomics
  • Membrane Fluidity
  • Membrane Lipids
  • Mice, Inbred C57BL
  • Mice, Knockout
  • Muscle, Skeletal
  • Myoblasts
  • Phospholipids
  • Protein-Serine-Threonine Kinases
  • Sarcopenia
  • Up-Regulation


Autophagy receptor OPTN (optineurin) regulates mesenchymal stem cell fate and bone-fat balance during aging by clearing FABP3.


Keywords

  • Adipogenesis
  • autophagy
  • bone metabolism
  • fabp3
  • mesenchymal stem cell
  • optineurin
  • osteogenesis
  • osteoporosis
  • senescence


Myokines as biomarkers of frailty and cardiovascular disease risk in females.


Keywords

  • Aging
  • Biomarkers
  • Cardiovascular disease
  • Females
  • Frailty
  • Myokines

FADS1[править]

Aging and FADS1 polymorphisms decrease the biosynthetic capacity of long-chain PUFAs: A human trial using [U- C]linoleic acid.


MeSH Terms

  • Adult
  • Age Factors
  • Aged
  • Aging
  • Alleles
  • Arachidonic Acid
  • Area Under Curve
  • Fatty Acid Desaturases
  • Fatty Acids, Unsaturated
  • Female
  • Healthy Volunteers
  • Humans
  • Linoleic Acid
  • Male
  • Polymorphism, Single Nucleotide

Keywords

  • Aging
  • Arachidonic acid
  • Fatty acid conversion
  • Linoleic acid
  • Lipid metabolism
  • Long-chain polyunsaturated fatty acid

FANCD2[править]

TFG-maintaining stability of overlooked FANCD2 confers early DNA-damage response.


Keywords

  • DNA damage response
  • FANCD2
  • TFG
  • aging and cancer

FAP[править]

Rapamycin Extends Life Span in Apc Colon Cancer FAP Model.


Keywords

  • Aging
  • Crypt stem cells
  • eEF2K
  • mTORC1
  • rpS6


Exercise enhances skeletal muscle regeneration by promoting senescence in fibro-adipogenic progenitors.


MeSH Terms

  • Aging
  • Animals
  • Apoptosis
  • Exercise Therapy
  • Female
  • Humans
  • Mesenchymal Stem Cells
  • Mice
  • Mice, Inbred BALB C
  • Mice, Inbred C57BL
  • Muscle, Skeletal
  • Muscular Diseases
  • Regeneration


Control of Muscle Fibro-Adipogenic Progenitors by Myogenic Lineage is Altered in Aging and Duchenne Muscular Dystrophy.


MeSH Terms

  • Adipogenesis
  • Adolescent
  • Adult
  • Adult Stem Cells
  • Aged
  • Aging
  • Cells, Cultured
  • Child
  • Child, Preschool
  • Female
  • Humans
  • Infant
  • Male
  • Middle Aged
  • Muscle Development
  • Muscular Dystrophy, Duchenne
  • Myoblasts
  • Young Adult

Keywords Adipocytes; Myofibroblasts; Muscle progenitors; Myopathies

FAS[править]

Five-year change in maximum tongue pressure and physical function in community-dwelling elderly adults.


Keywords

  • Aging
  • Biological age
  • Elderly
  • Physical function
  • Tongue pressure


Inhibition of USP7 activity selectively eliminates senescent cells in part via restoration of p53 activity.


Keywords

  • MDM2
  • Senescence
  • USP7
  • apoptosis
  • p53
  • senolytics

FES[править]

An outpatient Tai Chi program: Effects on veterans' functional outcomes.


Keywords

  • Tai Chi
  • balance
  • exercise
  • gait
  • geriatrics


Gait Function in Adults Aged 50 Years and Older With Spina Bifida.


Keywords

  • Adult
  • Aging
  • Gait analysis
  • Myelomeningocele
  • Rehabilitation


A Single Question as a Screening Tool to Assess Fear of Falling in Young-Old Community-Dwelling Persons.


Keywords

  • FES-I
  • elderly
  • fear of falling
  • healthy aging
  • older adults


Fall-related efficacy is a useful and independent index to detect fall risk in Japanese community-dwelling older people: a 1-year longitudinal study.


MeSH Terms

  • Accidental Falls
  • Activities of Daily Living
  • Aged
  • Aging
  • Female
  • Geriatric Assessment
  • Humans
  • Independent Living
  • Japan
  • Longitudinal Studies
  • Male
  • Physical Functional Performance
  • Postural Balance
  • Risk Factors
  • Walking Speed

Keywords

  • Accidental falls
  • Aged
  • Fall-related efficacy
  • Japanese
  • Physical performance


Investigating Changes in Real-time Conscious Postural Processing by Older Adults during Different Stance Positions Using Electroencephalography Coherence.


MeSH Terms

  • Accidental Falls
  • Aged
  • Aging
  • Brain
  • Electroencephalography
  • Fear
  • Female
  • Humans
  • Male
  • Movement
  • Postural Balance
  • Posture

FEV[править]

Prediction of Lung Function in Adolescence Using Epigenetic Aging: A Machine Learning Approach.


Keywords

  • epigenetic aging
  • feature selection
  • hyperparameter tuning
  • lung function
  • machine learning


Effect of Age on the Efficacy and Safety of Once-Daily Single-Inhaler Triple Therapy Fluticasone Furoate/Umeclidinium/Vilanterol in Patients With Chronic Obstructive Pulmonary Disease: A Post Hoc Analysis of the IMPACT Trial.


Keywords

  • COPD
  • aging
  • exacerbations
  • safety
  • single-inhaler triple therapy


A comprehensive analysis of factors related to lung function in older adults: Cross-sectional findings from the Canadian Longitudinal Study on Aging.


Keywords

  • Aging
  • Determinants
  • Lung function
  • Sex
  • Spirometry


Risk factors associated with the detection of pulmonary emphysema in older asymptomatic respiratory subjects.


Keywords

  • Aging
  • COPD
  • Klotho
  • Pulmonary emphysema
  • Risk factors
  • Telomere length


Tiotropium Respimat Efficacy and Safety in Asthma: Relationship to Age.


Keywords

  • Aging
  • Asthma
  • Long-acting muscarinic antagonist
  • Long-acting β(2)-agonists
  • Pharmacotherapy


Current Bronchodilator Responsiveness Criteria Underestimate Asthma in Older Adults.


Keywords

  • aging
  • albuterol
  • asthma
  • bronchodilator effect
  • lung diseases
  • older adult
  • spirometry


Physical performances show conflicting associations in aged manual workers.


MeSH Terms

  • Aged
  • Aging
  • Body Composition
  • Body Mass Index
  • Cardiorespiratory Fitness
  • Cross-Sectional Studies
  • Hand Strength
  • Humans
  • Lung
  • Male
  • Middle Aged
  • Physical Functional Performance


FEV as a Standalone Spirometric Predictor and the Attributable Fraction for Death in Older Persons.


Keywords

  • aging
  • average attributable fraction
  • death
  • relative risk
  • spirometry


An Individualized Prediction Model for Long-term Lung Function Trajectory and Risk of COPD in the General Population.


MeSH Terms

  • Adult
  • Age Factors
  • Aging
  • Alcohol Drinking
  • Algorithms
  • Alkaline Phosphatase
  • Body Height
  • Bronchodilator Agents
  • Cigarette Smoking
  • Cohort Studies
  • Cough
  • Dyspnea
  • Electrocardiography
  • Female
  • Forced Expiratory Volume
  • Hematocrit
  • Humans
  • Leukocyte Count
  • Longitudinal Studies
  • Lung
  • Machine Learning
  • Male
  • Middle Aged
  • Pulmonary Disease, Chronic Obstructive
  • Risk Assessment
  • Serum Albumin
  • Serum Globulins
  • Sex Factors
  • Spirometry
  • Triglycerides
  • Vital Capacity

Keywords

  • COPD
  • FEV(1)
  • FEV(1)/FVC
  • airflow limitation
  • lung function
  • predictive modeling


Telomere length and lung function in a population-based cohort of children and mid-life adults.


MeSH Terms

  • Aged
  • Asthma
  • Body Mass Index
  • Child
  • Cohort Studies
  • Cross-Sectional Studies
  • Exercise
  • Female
  • Forced Expiratory Volume
  • Humans
  • Lung
  • Male
  • Respiratory Function Tests
  • Risk Factors
  • Smoking
  • Spirometry
  • Telomere
  • Vital Capacity

Keywords

  • aging
  • cell senescence
  • life course
  • national cohort
  • spirometry

FGA[править]

Goal Pursuit, Goal Adjustment, and Pain in Middle-Aged Adults Aging With Physical Disability.


MeSH Terms

  • Adaptation, Psychological
  • Aged
  • Aging
  • Depression
  • Disabled Persons
  • Female
  • Goals
  • Humans
  • Male
  • Middle Aged
  • Multiple Sclerosis
  • Muscular Dystrophies
  • Pain
  • Postpoliomyelitis Syndrome
  • Spinal Cord Injuries

Keywords

  • aging
  • disability
  • goal management
  • pain
  • psychological adaptation


Tenacious Goal Pursuit, Flexible Goal Adjustment, and Life Satisfaction Among Chinese Older Adult Couples.


Keywords

  • flexible goal adjustment
  • life satisfaction
  • older couples
  • self-perceptions of aging
  • tenacious goal pursuit

FGF19[править]

Bile acid receptor agonists in primary biliary cholangitis: Regulation of the cholangiocyte secretome and downstream T cell differentiation.


Keywords

  • FGF19
  • FXR
  • TGR5
  • autoimmunity
  • senescence

FGF2[править]

The influence of fibroblast growth factor 2 on the senescence of human adipose-derived mesenchymal stem cells during long-term culture.


Keywords

  • cell proliferation
  • cellular senescence
  • fibroblast growth factor 2
  • long-term culture
  • mesenchymal stem cell

FGF21[править]

Differential effects of sulfur amino acid-restricted and low-calorie diets on gut microbiome profile and bile acid composition in male C57BL6/J mice.


Keywords

  • Clostridales
  • firmicutes
  • lifespan
  • methionine restriction
  • sulfur metabolism


Relationship between physical activity and circulating fibroblast growth factor 21 in middle-aged and older adults.


Keywords

  • Accelerometer
  • Activity intensity
  • Aging
  • FGF21
  • Physical activity


Exercise and dietary intervention ameliorate high-fat diet-induced NAFLD and liver aging by inducing lipophagy.


Keywords

  • Aging
  • Exercise
  • FGF21
  • Lipophagy
  • Nonalcoholic fatty liver disease (NAFLD)


Mitochondria, immunosenescence and inflammaging: a role for mitokines?


Keywords

  • Human ageing
  • Immunosenescence
  • Inflammaging
  • Mitochondrial metabolism
  • Mitokines


Age-at-onset-dependent effects of sulfur amino acid restriction on markers of growth and stress in male F344 rats.


Keywords

  • ER stress
  • cysteine
  • glutathione
  • hormesis
  • lifespan
  • methionine
  • trade-offs
  • translational


Fibroblast growth factor 21 prolongs lifespan and improves stress tolerance in the silkworm, [i]Bombyx mori[/i].


Keywords

  • Bombyx mori
  • fibroblast growth factor 21 (FGF21)
  • lifespan
  • oxidation resistance
  • stress tolerance


Neurogenesis and prolongevity signaling in young germ-free mice transplanted with the gut microbiota of old mice.


MeSH Terms

  • Animals
  • Butyrates
  • Fecal Microbiota Transplantation
  • Fibroblast Growth Factors
  • Gastrointestinal Microbiome
  • Germ-Free Life
  • Hippocampus
  • Intestines
  • Liver
  • Longevity
  • Male
  • Metabolome
  • Mice, Inbred C57BL
  • Microtubule-Associated Proteins
  • Neurogenesis
  • Neurons
  • Neuropeptides
  • Phenotype
  • Proton Magnetic Resonance Spectroscopy


Fibroblast Growth Factor 21 Mediates the Associations between Exercise, Aging, and Glucose Regulation.


MeSH Terms

  • Adiponectin
  • Adult
  • Aging
  • Blood Glucose
  • Blood Pressure
  • Body Mass Index
  • Diabetes Mellitus, Type 2
  • Exercise
  • Female
  • Fibroblast Growth Factors
  • Glucose Tolerance Test
  • Humans
  • Insulin
  • Lipids
  • Male
  • Middle Aged
  • Risk Factors


Effects of Moderate Chronic Food Restriction on the Development of Postprandial Dyslipidemia with Ageing.


MeSH Terms

  • Adiposity
  • Aging
  • Animals
  • Basic Helix-Loop-Helix Leucine Zipper Transcription Factors
  • Blood Glucose
  • Diet, Fat-Restricted
  • Dietary Fats
  • Disease Models, Animal
  • Dyslipidemias
  • Glucagon
  • Insulin
  • Lipids
  • Liver
  • Metabolic Syndrome
  • Postprandial Period
  • Rats
  • Rats, Wistar
  • Triglycerides

Keywords

  • ChREBP
  • adipose tissue
  • ageing
  • oral lipid loading test
  • postprandial hypertrigliceridemia
  • postprandial thermogenesis

FGF23[править]

Phosphate as a Pathogen of Arteriosclerosis and Aging.


Keywords

  • Aging
  • Calciprotein particles (CPPs)
  • Fibroblast growth factor-23 (FGF23)
  • Inflammation
  • Klotho
  • Phosphate
  • Vascular calcification


Plasma Soluble αKlotho, Serum Fibroblast Growth Factor 23, and Mobility Disability in Community-Dwelling Older Adults.


Keywords

  • aging
  • chronic kidney disease
  • fibroblast growth factor 23
  • mobility disability
  • αKlotho


Protective effect of Polygonatum sibiricum Polysaccharide on D-galactose-induced aging rats model.


MeSH Terms

  • Aging
  • Animals
  • Calcium
  • Dietary Carbohydrates
  • Fibroblast Growth Factors
  • Galactose
  • Glucuronidase
  • Male
  • Oxidative Stress
  • Phosphorus
  • Phytochemicals
  • Polygonatum
  • Polysaccharides
  • Protective Agents
  • Rats
  • Rats, Sprague-Dawley


FGF23 expression is stimulated in transgenic α-Klotho longevity mouse model.


MeSH Terms

  • Aldosterone
  • Animals
  • Bone and Bones
  • Cardiovascular Diseases
  • Disease Models, Animal
  • Female
  • Fibroblast Growth Factors
  • Gene Knockout Techniques
  • Glucuronidase
  • Kidney
  • Longevity
  • Male
  • Mice
  • Mice, Inbred C57BL
  • Mice, Transgenic
  • Osteoblasts
  • Protein Isoforms
  • Transcriptome

Keywords

  • Bone Biology
  • Cardiovascular disease


Fibroblast growth factor 23 and symmetric dimethylarginine concentrations in geriatric cats.


MeSH Terms

  • Aging
  • Animals
  • Arginine
  • Biomarkers
  • Cats
  • Cross-Sectional Studies
  • Female
  • Fibroblast Growth Factors
  • Male
  • Reference Values
  • Retrospective Moral Judgment

Keywords

  • azotemia
  • feline
  • phosphate
  • renal

FGFR1[править]

Alignment of Alzheimer's disease amyloid β-peptide and klotho.


Keywords

  • Alzheimer’s disease
  • HSV-1
  • aging
  • alignment
  • klotho
  • neurodegeneration
  • neuroinflammation
  • protein
  • ubiquitin
  • β-amyloid


Satellite cell-specific ablation of Cdon impairs integrin activation, FGF signalling, and muscle regeneration.


Keywords

  • Cdon
  • Cellular senescence
  • FGFR
  • Growth factor signalling
  • Muscle regeneration
  • Satellite cell

FGFR4[править]

FGFR4 Inhibitor BLU9931 Attenuates Pancreatic Cancer Cell Proliferation and Invasion While Inducing Senescence: Evidence for Senolytic Therapy Potential in Pancreatic Cancer.


Keywords

  • FGFR4
  • FGFR4 inhibitor
  • growth
  • invasion
  • pancreatic cancer
  • senescence
  • senolytic therapy

FGR[править]

Aurora kinase mRNA expression is reduced with increasing gestational age and in severe early onset fetal growth restriction.


Keywords

  • Aurora kinase
  • Cellular senescence
  • FGR
  • Preeclampsia

FH[править]

Genetic Factors of Alzheimer's Disease Modulate How Diet is Associated with Long-Term Cognitive Trajectories: A UK Biobank Study.


Keywords

  • APOE4
  • Aging
  • Mediterranean diet
  • cognitive decline
  • functional food
  • lamb
  • nutrition policy
  • preventive medicine
  • red wine
  • salt


Volumetric alterations in the hippocampal subfields of subjects at increased risk of dementia.


MeSH Terms

  • Adult
  • Aging
  • Alzheimer Disease
  • Apolipoproteins E
  • Atrophy
  • Dementia
  • Diffusion Magnetic Resonance Imaging
  • Educational Status
  • Female
  • Genotype
  • Hippocampus
  • Humans
  • Male
  • Middle Aged
  • Organ Size
  • Risk

Keywords

  • Alzheimer's disease
  • Dementia
  • Hippocampal subfields
  • Hippocampus
  • Preclinical dementia


Macroscopic hematuria as a risk factor for hypertension in ageing people with hemophilia and a family history of hypertension.


MeSH Terms

  • Adult
  • Aged
  • Aged, 80 and over
  • Aging
  • Cross-Sectional Studies
  • Female
  • Hematuria
  • Hemophilia A
  • Humans
  • Hypertension
  • Israel
  • Logistic Models
  • Male
  • Middle Aged
  • Risk Factors


LDL Receptor Deficiency Does not Alter Brain Amyloid-β Levels but Causes an Exacerbation of Apoptosis.


MeSH Terms

  • Aging
  • Amyloid beta-Protein Precursor
  • Animals
  • Apoptosis
  • Brain Chemistry
  • Caspase 3
  • Cholesterol
  • Gene Expression
  • Hippocampus
  • Male
  • Maze Learning
  • Mice
  • Mice, Inbred C57BL
  • Mice, Knockout
  • Prefrontal Cortex
  • Receptors, LDL

Keywords

  • Familial hypercholesterolemia
  • LDLr-/- mice
  • amyloid-β
  • apoptosis
  • memory impairment

FNDC5[править]

Irisin Correlates Positively With BMD in a Cohort of Older Adult Patients and Downregulates the Senescent Marker p21 in Osteoblasts.


Keywords

  • BONE-MUSCLE INTERACTIONS
  • IRISIN
  • OSTEOPOROSIS
  • SARCOPENIA
  • SENESCENCE


[Investigation of signal molecules in saliva: prospects of application for diagnostics of myocardial infarction and the aging rate of different age people.]


MeSH Terms

  • Aged
  • Aging
  • Biomarkers
  • Cytokines
  • Humans
  • Middle Aged
  • Myocardial Infarction
  • Saliva
  • Tumor Necrosis Factor-alpha

Keywords

  • aging
  • diagnosis
  • myocardial infarction
  • saliva
  • signaling molecules

FOS[править]

Muscle atrophy-related myotube-derived exosomal microRNA in neuronal dysfunction: Targeting both coding and long noncoding RNAs.


Keywords

  • HIF-1α-AS2
  • aging
  • lncRNAs
  • miR-29b-3p
  • muscle atrophy

FOSL2[править]

LncRNA GUARDIN suppresses cellular senescence through a LRP130-PGC1α-FOXO4-p21-dependent signaling axis.


Keywords

GUARDIN

  • LRP130-PGC1α
  • cellular senescence
  • lncRNAs
  • p21

FOXA1[править]

Analyses of an epigenetic switch involved in the activation of pioneer factor FOXA1 leading to the prognostic value of estrogen receptor and FOXA1 co-expression in breast cancer.


MeSH Terms

  • Breast Neoplasms
  • Down-Regulation
  • Epigenesis, Genetic
  • Female
  • Gene Expression Regulation, Neoplastic
  • Hepatocyte Nuclear Factor 3-alpha
  • Humans
  • Middle Aged
  • Prognosis
  • RNA, Messenger
  • Receptor, ErbB-2
  • Receptors, Estrogen
  • Receptors, Progesterone
  • Transcriptome
  • Up-Regulation

Keywords

  • FOXA1
  • age-related diseases
  • aging
  • breast cancer
  • hormone receptor
  • methylation
  • prognosis

FOXM1[править]

Sirtuin 6 deficiency induces endothelial cell senescence via downregulation of forkhead box M1 expression.


Keywords

  • FOXM1
  • SIRT6
  • cell cycle
  • endothelial cell
  • senescence

FOXN1[править]

Thymic rejuvenation via FOXN1-reprogrammed embryonic fibroblasts (FREFs) to counteract age-related inflammation.


Keywords

  • Aging
  • Immunology
  • Immunotherapy
  • T cell development

FOXO1[править]

l-Theanine attenuates liver aging by inhibiting advanced glycation end products in d-galactose-induced rats and reversing an imbalance of oxidative stress and inflammation.


Keywords

  • AGEs
  • Inflammatory response
  • Liver aging
  • Oxidative stress
  • l-Theanine

FOXO3[править]

The DNA methylation of FOXO3 and TP53 as a blood biomarker of late-onset asthma.


Keywords

  • Aging
  • DNA methylation
  • FOXO3
  • Late-onset asthma
  • TP53


FOXO3 targets are reprogrammed as Huntington's disease neural cells and striatal neurons face senescence with p16 increase.


Keywords

  • neurodegenerative disease
  • neuronal differentiation
  • neuronal senescence
  • response mechanisms
  • temporal dynamics


Astaxanthin as a Putative Geroprotector: Molecular Basis and Focus on Brain Aging.


Keywords

  • FOXO3
  • NRF2
  • SIRT1
  • astaxanthin
  • geroprotector
  • longevity
  • neuroprotection


Inflamma-miR-21 Negatively Regulates Myogenesis during Ageing.


Keywords

  • IL6
  • IL6R
  • aging
  • cachexia
  • miR-21
  • microRNA
  • muscle
  • regeneration
  • sarcopenia


Variable DNA methylation of aging-related genes is associated with male COPD.


MeSH Terms

  • Adolescent
  • Adult
  • Age Factors
  • Aged
  • Aged, 80 and over
  • Aging
  • Case-Control Studies
  • CpG Islands
  • DNA Methylation
  • Databases, Genetic
  • Female
  • Forced Expiratory Volume
  • Forkhead Transcription Factors
  • Genetic Predisposition to Disease
  • Humans
  • Lung
  • Male
  • Middle Aged
  • Pulmonary Disease, Chronic Obstructive
  • Risk Assessment
  • Risk Factors
  • Severity of Illness Index
  • Sex Factors
  • Transcriptome
  • Vital Capacity
  • Young Adult

Keywords

  • Aging
  • Aging-related genes
  • COPD
  • DNA methylation


A conserved role of the insulin-like signaling pathway in diet-dependent uric acid pathologies in Drosophila melanogaster.


MeSH Terms

  • Animals
  • Animals, Genetically Modified
  • Cohort Studies
  • Disease Models, Animal
  • Drosophila melanogaster
  • Feeding Behavior
  • Female
  • Gene Knockdown Techniques
  • Gout
  • Humans
  • Insulin
  • Kidney Calculi
  • Longevity
  • Male
  • Metabolic Networks and Pathways
  • Middle Aged
  • NADPH Oxidases
  • Polymorphism, Single Nucleotide
  • Purines
  • Signal Transduction
  • Urate Oxidase
  • Uric Acid

FOXO4[править]

FOXO4-DRI alleviates age-related testosterone secretion insufficiency by targeting senescent Leydig cells in aged mice.


Keywords

  • FOXO4-DRI
  • Leydig cell
  • male late-onset hypogonadism
  • senescence
  • senolytics

FOXP1[править]

GATA6 regulates aging of human mesenchymal stem/stromal cells.


Keywords

  • aging
  • cell signaling
  • mesenchymal stem cells
  • reprogramming
  • transcription factors

FSHR[править]

FSHR ablation induces depression-like behaviors.


Keywords

  • FSH
  • ROS
  • aging
  • antioxidants
  • depression
  • metabolism


Direct actions of gonadotropins beyond the reproductive system and their role in human aging and neoplasia [Bezpośrednie działanie gonadotropin poza układem rozrodczym i ich rola w starzeniu się i nowotworzeniu u człowieka].


MeSH Terms

  • Aging
  • Female
  • Gonadotropin-Releasing Hormone
  • Gonadotropins
  • Humans
  • Hypothalamo-Hypophyseal System
  • Luteinizing Hormone
  • Male
  • Receptors, FSH
  • Receptors, LH

Keywords

  • aging
  • folitropin
  • lutropin
  • neoplasia

FTO[править]

Decreased expression of m A demethylase FTO in ovarian aging.


Keywords

  • Epigenetics
  • FTO
  • Ovarian aging
  • Ovarian reserve
  • m6A

FYN[править]

An inhibitor role of Nrf2 in the regulation of myocardial senescence and dysfunction after myocardial infarction.


MeSH Terms

  • Animals
  • Cardiomyopathies
  • Cellular Senescence
  • Echocardiography
  • Gene Silencing
  • Male
  • Mice
  • Mice, Inbred C57BL
  • Mice, Knockout
  • Myocardial Infarction
  • Myocardium
  • Myocytes, Cardiac
  • NF-E2-Related Factor 2
  • RNA, Small Interfering
  • Ventricular Remodeling

Keywords

  • Cellular senescence
  • Myocardial infarction
  • Nrf2
  • Oxidative stress

G6PD[править]

G6PD overexpression protects from oxidative stress and age-related hearing loss.


Keywords

  • ARHL
  • NADPH
  • TrxR
  • aging
  • glutathione


The Sickle Effect: The Silent Titan Affecting Glycated Hemoglobin Reliability.


Keywords

  • diabetes
  • genetics
  • glycosylated hemoglobin
  • hba1c
  • hbas
  • race
  • rbc lifespan
  • sickle cell trait


DNA damage and synaptic and behavioural disorders in glucose-6-phosphate dehydrogenase-deficient mice.


MeSH Terms

  • Animals
  • Brain
  • DNA Breaks, Double-Stranded
  • DNA Breaks, Single-Stranded
  • DNA Damage
  • Disease Models, Animal
  • Enzyme Activation
  • Female
  • Glucosephosphate Dehydrogenase
  • Glucosephosphate Dehydrogenase Deficiency
  • Male
  • Mental Disorders
  • Mice
  • Oxidation-Reduction
  • Purkinje Cells

Keywords

  • 8-Oxo-2′-deoxyguanine (8-oxodG)
  • Aging
  • Behavioural disorders
  • Comet
  • DNA damage
  • Electrophysiology
  • Gamma-H2AX (γH2AX)
  • Glucose-6-phosphate dehydrogenase (G6PD)
  • Lifespan
  • Neurodegeneration
  • Reactive oxygen species (ROS)

GAA[править]

Mitochondrial damage and senescence phenotype of cells derived from a novel frataxin G127V point mutation mouse model of Friedreich's ataxia.


Keywords

  • Frataxin
  • Friedreich's ataxia
  • Mitochondria
  • Oxidative stress
  • Point mutation
  • Senescence


Age-Related Changes in Serum Guanidinoacetic Acid in Women.


MeSH Terms

  • Adolescent
  • Adult
  • Aged
  • Aging
  • Biomarkers
  • Energy Metabolism
  • Exercise
  • Female
  • Glycine
  • Humans
  • Independent Living
  • Middle Aged
  • Young Adult

GABARAP[править]

Age-dependent loss of adipose Rubicon promotes metabolic disorders via excess autophagy.


MeSH Terms

  • Adipocytes
  • Adipogenesis
  • Adipose Tissue
  • Adiposity
  • Aging
  • Animals
  • Apoptosis Regulatory Proteins
  • Autophagy
  • Fatty Liver
  • Gene Knockout Techniques
  • Glucose
  • HEK293 Cells
  • Humans
  • Intracellular Signaling Peptides and Proteins
  • Lipid Metabolism
  • Metabolic Diseases
  • Mice
  • Mice, Inbred C57BL
  • Mice, Knockout
  • Microtubule-Associated Proteins
  • Nuclear Receptor Coactivator 1
  • Nuclear Receptor Coactivator 2
  • PPAR gamma

GAL[править]

Overexpression of Pitx1 attenuates the senescence of chondrocytes from osteoarthritis degeneration cartilage-A self-controlled model for studying the etiology and treatment of osteoarthritis.


Keywords

  • Osteoarthritis
  • Pitx1
  • Senescence
  • Sirt1


β-Caryophyllene Reduces DNA Oxidation and the Overexpression of Glial Fibrillary Acidic Protein in the Prefrontal Cortex and Hippocampus of d-Galactose-Induced Aged BALB/c Mice.


MeSH Terms

  • Aging
  • Animals
  • Antioxidants
  • DNA Damage
  • Disease Models, Animal
  • Galactose
  • Glial Fibrillary Acidic Protein
  • Hippocampus
  • Male
  • Mice
  • Mice, Inbred BALB C
  • Neuroprotection
  • Oxidative Stress
  • Polycyclic Sesquiterpenes
  • Prefrontal Cortex

Keywords

  • CB2 receptor agonist
  • biological aging
  • cognitive flexibility
  • phytocannabinoid
  • β-caryophyllene

GAP43[править]

HDAC inhibition leads to age-dependent opposite regenerative effect upon PTEN deletion in rubrospinal axons after SCI.


MeSH Terms

  • Aging
  • Animals
  • Axons
  • GAP-43 Protein
  • Gene Deletion
  • Gene Expression
  • Histone Deacetylase Inhibitors
  • Histone Deacetylases
  • Hydroxamic Acids
  • Mice, Transgenic
  • Motor Activity
  • Nerve Regeneration
  • PTEN Phosphohydrolase
  • Recovery of Function
  • Spinal Cord
  • Spinal Cord Injuries

Keywords

  • Aging
  • Epigenetics
  • Histone deacetylase
  • Pten
  • Regeneration
  • Spinal cord injury

GATA4[править]

Epigenetics and Vascular Senescence-Potential New Therapeutic Targets?


Keywords

  • calcification
  • cell senescence
  • epigenetics
  • inflammation
  • oxidation stress
  • vascular aging


Prolonged treatment with Y-27632 promotes the senescence of primary human dermal fibroblasts by increasing the expression of IGFBP-5 and transforming them into a CAF-like phenotype.


Keywords

  • IGFBP-5
  • Rho kinase inhibitor
  • Y-27632
  • dermal fibroblast
  • senescence

GBA[править]

Reduced sphingolipid hydrolase activities, substrate accumulation and ganglioside decline in Parkinson's disease.


MeSH Terms

  • Aged
  • Aging
  • Female
  • Glucosylceramidase
  • Humans
  • Hydrolases
  • Lysosomes
  • Male
  • Mutation
  • Parkinson Disease
  • Risk Factors
  • Substantia Nigra
  • alpha-Synuclein

Keywords

  • Ageing
  • Ganglioside
  • Glucocerebrosidase
  • Glycosphingolipid
  • Lysosome
  • Neurodegeneration
  • Parkinson’s disease

GC[править]

Body Size and Cuticular Hydrocarbons as Larval Age Indicators in the Forensic Blow Fly, Chrysomya albiceps (Diptera: Calliphoridae).


Keywords 

         Chrysomya albiceps
  • body size
  • cuticular hydrocarbon
  • forensic
  • larval longevity


Composition of peony petal fatty acids and flavonoids and their effect on Caenorhabditis elegans lifespan.


Keywords

  • Caenorhabditis elegans
  • Fatty acid
  • Flavonoid identification and composition
  • Lifespan extension
  • Tree peony petal


Photo aging and fragmentation of polypropylene food packaging materials in artificial seawater.


Keywords

  • Aging
  • Antioxidant
  • Food packaging materials
  • Microplastics
  • Polypropylene
  • seawater


Secretory galectin-3 induced by glucocorticoid stress triggers stemness exhaustion of hepatic progenitor cells.


Keywords

  • AMP-activated kinase (AMPK)
  • Cell senescence
  • cell cycle
  • cellular senescence
  • galectin
  • galectin-3
  • glycoprotein
  • liver injury
  • proliferation
  • protein interaction
  • protein-protein interaction
  • quiescence
  • stem cells
  • stemness exhaustion


Optimization of Ethanol Detection by Automatic Headspace Method for Cellulose Insulation Aging of Oil-immersed Transformers.


Keywords

  • aging
  • cellulose insulation
  • gas chromatography
  • headspace sampling


Sensory, olfactometric and chemical characterization of the aroma potential of Garnacha and Tempranillo winemaking grapes.


MeSH Terms

  • Fruit
  • Gas Chromatography-Mass Spectrometry
  • Hexanols
  • Norisoprenoids
  • Odorants
  • Olfactometry
  • Principal Component Analysis
  • Sulfhydryl Compounds
  • Vitis
  • Volatile Organic Compounds

Keywords

  • Aging
  • Aroma precursors
  • Glycosides
  • Lipid-derived aroma
  • Norisoprenoids
  • Sensory properties
  • Terpenols
  • Volatile phenols


Accelerated Cognitive Ageing in epilepsy: exploring the effective connectivity between resting-state networks and its relation to cognitive decline.


Keywords

  • Accelerated cognitive ageing
  • Ageing
  • Aging
  • Biomarkers
  • Clinical research
  • Cognition
  • Cognitive decline
  • Cognitive neuroscience
  • Effective connectivity
  • Epilepsy
  • Fmri
  • Granger causality
  • Image processing
  • Medical imaging
  • Mental health
  • Nervous system
  • Neuroscience
  • Psychiatry


Characterization of Jinhua ham aroma profiles in specific to aging time by gas chromatography-ion mobility spectrometry (GC-IMS).


Keywords

  • Aging
  • Electronic-nose
  • Gas chromatography-ion mobility spectrometry
  • Jinhua ham
  • Volatiles


Quantitative Profiling of Lipid Species in Caenorhabditis elegans with Gas Chromatography-Mass Spectrometry.


Keywords

  • Aging
  • C. elegans
  • Fat
  • Fatty acids
  • Gas chromatography–mass spectrometry
  • Lipids
  • Phospholipids
  • Solid-phase chromatography
  • Triglycerides


Physicochemical characterization of a polysaccharide from Agrocybe aegirita and its anti-ageing activity.


MeSH Terms

  • Aging
  • Agrocybe
  • Antioxidants
  • Carbohydrate Sequence
  • Cell Line
  • Chemical Phenomena
  • G1 Phase Cell Cycle Checkpoints
  • Humans
  • Membrane Potential, Mitochondrial
  • Mitochondria
  • Polysaccharides

Keywords

  • Agrocybe aegirita polysaccharide
  • Anti-ageing
  • Cell cycle
  • Mitochondrial membrane potential
  • Structure


Structural characteristics, antioxidant properties and antiaging activities of galactan produced by Mentha haplocalyx Briq.


MeSH Terms

  • Aging
  • Animals
  • Antioxidants
  • Biphenyl Compounds
  • Carbohydrate Conformation
  • Galactans
  • Male
  • Mentha
  • Mice
  • Mice, Inbred Strains
  • Particle Size
  • Picrates
  • Surface Properties

Keywords

  • Anti-aging activity
  • Antioxidant activity
  • Mentha haplocalyx Briq
  • Polysaccharides


Contribution of Volatile Odorous Terpenoid Compounds to Aged Cognac Spirits Aroma in a Context of Multicomponent Odor Mixtures.


Keywords

  • Cognac
  • aging aroma
  • lees
  • monoterpenes
  • perceptual synergic effects


Plasma Formate Is Greater in Fetal and Neonatal Rats Compared with Their Mothers.


MeSH Terms

  • Aging
  • Animals
  • Animals, Newborn
  • Female
  • Fetus
  • Formates
  • Liver
  • Maternal-Fetal Exchange
  • Mothers
  • Placenta
  • Pregnancy
  • Rats
  • Rats, Sprague-Dawley

Keywords

  • fetus
  • glycine
  • methionine
  • mitochondria
  • one-carbon metabolism
  • pregnancy
  • serine
  • tetrahydrofolate


Development of a new strategy for studying the aroma potential of winemaking grapes through the accelerated hydrolysis of phenolic and aromatic fractions (PAFs).


Keywords

  • Aging
  • Glycosidic precursors
  • Grape aroma
  • Grape quality
  • Hydrolysis
  • Polyphenols
  • Wine


Compromised steady-state germinal center activity with age in nonhuman primates.


MeSH Terms

  • Aging
  • Animals
  • Antigens, CD
  • B-Lymphocytes
  • CD4-Positive T-Lymphocytes
  • CD8-Positive T-Lymphocytes
  • Forkhead Transcription Factors
  • Germinal Center
  • Granulocytes
  • Immunity, Humoral
  • Inflammation
  • Lymph Nodes
  • Macaca mulatta
  • Monocytes

Keywords

  • B cells
  • Tfh cells
  • aging
  • follicles


Endogenous Glucocorticoid Signaling in the Regulation of Bone and Marrow Adiposity: Lessons from Metabolism and Cross Talk in Other Tissues.


MeSH Terms

  • Adipose Tissue
  • Adiposity
  • Animals
  • Bone Marrow
  • Energy Metabolism
  • Glucocorticoids
  • Homeostasis
  • Humans
  • Liver
  • Muscle, Skeletal
  • Receptor Cross-Talk
  • Receptors, Glucocorticoid
  • Signal Transduction
  • Stress, Physiological

Keywords

  • Adipocyte
  • Aging
  • Bone marrow
  • Corticosterone
  • Cortisol
  • Cortisone
  • Glucocorticoid
  • Osteoblast


4,5-Diphenyl-2-methyl picolinate induces cellular senescence by accumulating DNA damage and activating associated signaling pathways in gastric cancer.


MeSH Terms

  • Animals
  • Antineoplastic Agents
  • Apoptosis
  • Cell Cycle
  • Cell Proliferation
  • Cellular Senescence
  • DNA Damage
  • Humans
  • Mice
  • Mice, Inbred BALB C
  • Mice, Nude
  • Picolinic Acids
  • Signal Transduction
  • Stomach Neoplasms
  • Tumor Cells, Cultured
  • Xenograft Model Antitumor Assays

Keywords

  • Cellular senescence
  • DNA damage
  • Gastric cancer
  • N-heterocyclic compound


Relationship Between the Dose Administered, Target Tissue Dose, and Toxicity Level After Acute Oral Exposure to Bifenthrin and Tefluthrin in Young Adult Rats.


MeSH Terms

  • Administration, Oral
  • Aging
  • Animals
  • Body Temperature
  • Cerebellum
  • Cyclopropanes
  • Dose-Response Relationship, Drug
  • Hydrocarbons, Fluorinated
  • Liver
  • Male
  • Pyrethrins
  • Rats
  • Rats, Wistar
  • Tissue Distribution
  • Toxicokinetics

Keywords

  • acute effects
  • bifenthrin
  • body temperature
  • disposition
  • rat
  • tefluthrin


Sugar Beet Pectin Supplementation Did Not Alter Profiles of Fecal Microbiota and Exhaled Breath in Healthy Young Adults and Healthy Elderly.


MeSH Terms

  • Aged
  • Beta vulgaris
  • Breath Tests
  • Dietary Supplements
  • Double-Blind Method
  • Exhalation
  • Fatty Acids, Volatile
  • Feces
  • Female
  • Gastrointestinal Microbiome
  • Healthy Volunteers
  • Humans
  • Male
  • Pectins
  • Volatile Organic Compounds
  • Young Adult

Keywords

  • aging
  • dietary fiber
  • elderly
  • exhaled air
  • microbiota
  • pectin
  • young adults


Identification and analysis of new α- and β-hydroxy ketones related to the formation of 3-methyl-2,4-nonanedione in musts and red wines.


MeSH Terms

  • Alkanes
  • Diacetyl
  • Ethanol
  • Fruit and Vegetable Juices
  • Gas Chromatography-Mass Spectrometry
  • Humans
  • Hydrogen-Ion Concentration
  • Ketones
  • Limit of Detection
  • Solid Phase Microextraction
  • Stereoisomerism
  • Time Factors
  • Wine

Keywords

  • 3-methyl-2,4-nonanedione
  • Aroma precursor
  • Hydroxy ketones
  • Oxidation
  • Premature aging
  • Wine


Neonatal T Follicular Helper Cells Are Lodged in a Pre-T Follicular Helper Stage Favoring Innate Over Adaptive Germinal Center Responses.


MeSH Terms

  • Adaptive Immunity
  • Adjuvants, Immunologic
  • Aging
  • Animals
  • Animals, Newborn
  • Germinal Center
  • Immunity, Innate
  • Interleukin-13
  • Lymphopoiesis
  • Mice, Inbred C57BL
  • T-Lymphocytes, Helper-Inducer
  • Th2 Cells
  • Transcriptome

Keywords

  • T follicular helper cells
  • adjuvant
  • neonates
  • transcriptional profile analysis
  • vaccines


Identification of Dialkylpyrazines Off-Flavors in Oak Wood.


MeSH Terms

  • Flavoring Agents
  • Gas Chromatography-Mass Spectrometry
  • Odorants
  • Olfactometry
  • Pyrazines
  • Quercus
  • Wood

Keywords

  • aroma
  • barrel aging
  • dialkylpyrazine
  • oak wood
  • off-flavor
  • wine


Metabolomics Coupled with Transcriptomics Approach Deciphering Age Relevance in Sepsis.


Keywords

  • aging
  • biomarker
  • metabolomics
  • sepsis
  • transcriptomics

GCA[править]

Familial aggregation of longevity in giant cell arteritis and polymyalgia rheumatica.


Keywords

  • Giant cell arteritis
  • Longevity
  • Mortality
  • Polymyalgia rheumatica


Interaction between Alcohol Consumption and Apolipoprotein E (ApoE) Genotype with Cognition in Middle-Aged Men.


Keywords

  • Aging
  • Alcohol drinking
  • Apolipoprotein E4 (ApoE)
  • Cognitive abilities
  • Male
  • Middle aged
  • Risk factors

GCK[править]

The Impact of Biomarker Screening and Cascade Genetic Testing on the Cost-Effectiveness of MODY Genetic Testing.


MeSH Terms

  • Biomarkers
  • Child
  • Cost-Benefit Analysis
  • Diabetes Mellitus, Type 2
  • Female
  • Genetic Testing
  • Health Care Costs
  • Humans
  • Life Expectancy
  • Male
  • Mass Screening
  • Pedigree
  • Precision Medicine
  • Quality-Adjusted Life Years

GCLC[править]

Aerobic exercise training partially reverses the impairment of Nrf2 activation in older humans.


Keywords

  • Aging
  • Exercise
  • GCLC
  • NQO1
  • Nrf2 signaling
  • Redox homeostasis

GCLM[править]

Silencing Bach1 alters aging-related changes in the expression of Nrf2-regulated genes in primary human bronchial epithelial cells.


MeSH Terms

  • Adult
  • Aged
  • Aging
  • Basic-Leucine Zipper Transcription Factors
  • Bronchi
  • Epithelial Cells
  • Gene Expression
  • Gene Silencing
  • Glutamate-Cysteine Ligase
  • Heme Oxygenase-1
  • Humans
  • Isothiocyanates
  • Middle Aged
  • NAD(P)H Dehydrogenase (Quinone)
  • NF-E2-Related Factor 2
  • RNA, Messenger
  • RNA, Small Interfering
  • Signal Transduction
  • Young Adult

Keywords

  • Aging
  • Bach1
  • Glutamate cysteine ligase
  • Heme oxygenase
  • Nrf2
  • Sulforaphane

GDF11[править]

Growth differentiation factor-11 supplementation improves survival and promotes recovery after ischemic stroke in aged mice.


Keywords

  • GDF11
  • White matter integrity
  • aging
  • gliosis
  • stroke


Anti-Aging Effects of GDF11 on Skin.


Keywords

  • disease
  • growth factors
  • regeneration
  • skin aging


Targeted Approach to Distinguish and Determine Absolute Levels of GDF8 and GDF11 in Mouse Serum.


Keywords

  • GDF11
  • aging
  • immunoprecipitation
  • myostatin/GDF8
  • serum
  • targeted-quantitative proteomics


Growth differentiation factor 11 impairs titanium implant healing in the femur and leads to mandibular bone loss.


Keywords

  • aging
  • alveolar bone loss
  • dental implants
  • osseointegration
  • transforming growth factors


Systemic GDF11 stimulates the secretion of adiponectin and induces a calorie restriction-like phenotype in aged mice.


Keywords

  • GDF11
  • adiponectin
  • aging
  • calorie restriction
  • heterochronic parabiosis
  • rejuvenation


Circulating factors in young blood as potential therapeutic agents for age-related neurodegenerative and neurovascular diseases.


MeSH Terms

  • Age Factors
  • Aging
  • Animals
  • Blood
  • Bone Morphogenetic Proteins
  • Chemokine CCL11
  • Enzyme Therapy
  • Enzymes
  • Growth Differentiation Factors
  • Mice
  • Neurodegenerative Diseases
  • Parabiosis
  • Vascular Diseases

Keywords

  • C-C motif chemokine 11
  • Circulating factor
  • Growth differentiation factor 11
  • Neurodegenerative diseases
  • Neurovascular diseases
  • Young blood


Effects of Exercise Training on Growth and Differentiation Factor 11 Expression in Aged Mice.


Keywords

  • aging
  • exercise
  • growth and differentiation factor 11
  • sarcopenia
  • skeletal muscle

GDF15[править]

Disease-specific plasma levels of mitokines FGF21, GDF15, and Humanin in type II diabetes and Alzheimer's disease in comparison with healthy aging.


Keywords

  • AD
  • Aging
  • FGF21
  • GDF15
  • Humanin
  • T2D


Growth differentiation factor 15 protects against the aging-mediated systemic inflammatory response in humans and mice.


Keywords

  • T cell
  • aging
  • inflammation
  • mitochondria
  • senescence


Analysis of Epigenetic Age Predictors in Pain-Related Conditions.


Keywords

  • DNA methylation
  • aging biomarker
  • chronic pain
  • epigenetic aging
  • epigenetic clock
  • fibromyalgia
  • headache
  • pain sensitivity


GDF15 Plasma Level Is Inversely Associated With Level of Physical Activity and Correlates With Markers of Inflammation and Muscle Weakness.


Keywords

  • GDF15
  • healthy aging
  • inflammation
  • physical activity
  • sedentarity
  • skeletal muscle


GDF15 is an epithelial-derived biomarker of idiopathic pulmonary fibrosis.


MeSH Terms

  • Aged
  • Alveolar Epithelial Cells
  • Animals
  • Bleomycin
  • Bronchoalveolar Lavage Fluid
  • Case-Control Studies
  • Disease Models, Animal
  • Female
  • Gene Expression Profiling
  • Growth Differentiation Factor 15
  • Humans
  • Idiopathic Pulmonary Fibrosis
  • Lung
  • Male
  • Mice
  • Middle Aged
  • Respiratory Function Tests
  • Severity of Illness Index
  • Survival Analysis
  • Telomere
  • Transcriptome

Keywords

  • MIC-1
  • NAG-1
  • SASP
  • aging


Senescence-associated tissue microenvironment promotes colon cancer formation through the secretory factor GDF15.


MeSH Terms

  • Aging
  • Cells, Cultured
  • Cellular Senescence
  • Colonic Neoplasms
  • Fibroblasts
  • Growth Differentiation Factor 15
  • HEK293 Cells
  • Humans
  • Phenotype
  • RNA, Messenger
  • Tumor Microenvironment

Keywords

  • GDF15
  • colon organoids
  • colorectal cancer
  • microenvironment
  • senescence

GDF5[править]

An embryonic CaVβ1 isoform promotes muscle mass maintenance via GDF5 signaling in adult mouse.


MeSH Terms

  • Adult
  • Aged
  • Aged, 80 and over
  • Aging
  • Animals
  • Atrophy
  • Calcium Channels, L-Type
  • Denervation
  • Embryo, Mammalian
  • Exons
  • Female
  • Gene Expression Regulation, Developmental
  • Growth Differentiation Factor 5
  • Humans
  • Male
  • Mice
  • Muscles
  • Neuromuscular Junction
  • Organ Size
  • Physical Conditioning, Animal
  • Protein Isoforms
  • RNA Splicing
  • Signal Transduction
  • Young Adult

GDNF[править]

GFR-α1 Expression in Substantia Nigra Increases Bilaterally Following Unilateral Striatal GDNF in Aged Rats and Attenuates Nigral Tyrosine Hydroxylase Loss Following 6-OHDA Nigrostriatal Lesion.


MeSH Terms

  • Aging
  • Animals
  • Dopamine
  • Glial Cell Line-Derived Neurotrophic Factor
  • Glial Cell Line-Derived Neurotrophic Factor Receptors
  • Neurons
  • Oxidopamine
  • Phosphorylation
  • Rats
  • Substantia Nigra
  • Tyrosine 3-Monooxygenase

Keywords

  • 6-hydroxydopamine
  • Parkinson’s disease
  • Substantia nigra
  • aging
  • nigrostriatal
  • tyrosine hydroxylase

GEM[править]

The Impact of Geriatric Emergency Management Nurses on the Care of Frail Older Patients in the Emergency Department: a Systematic Review.


Keywords

  • emergency department
  • geriatric emergency management nurses
  • geriatrics

GFAP[править]

Immunohistological Detection of Active Satellite Cellsin Rat Dorsal Root Ganglia after Parenteral Administration of Lipopolysaccharide and during Aging.


Keywords

  • aging
  • dorsal root ganglion
  • satellite cells
  • systemic inflammation


Transgenic Mice Expressing Human α-Synuclein in Noradrenergic Neurons Develop Locus Ceruleus Pathology and Nonmotor Features of Parkinson's Disease.


Keywords

  • Parkinson's disease
  • aging
  • locus ceruleus
  • nonmotor
  • norepinephrine
  • α-synuclein


ApoE Genotype-Dependent Response to Antioxidant and Exercise Interventions on Brain Function.


Keywords

  • Alzheimer’s disease
  • ApoE
  • aging
  • antioxidants
  • cognition
  • exercise
  • motor
  • oxidative stress
  • vitamin C
  • vitamin E


Age-Dependent Heterogeneity of Murine Olfactory Bulb Astrocytes.


Keywords

  • Sholl analysis
  • aging
  • astrocyte
  • cell morphology
  • heterogeneity
  • olfactory bulb


Neuroinflammation in Aged Brain: Impact of the Oral Administration of Ellagic Acid Microdispersion.


Keywords

  • CD45
  • EA microdispersion (EAm)
  • GFAP
  • aging
  • behavioral skills
  • ellagic acid (EA)
  • mice
  • noradrenaline
  • oral administration
  • principal component analysis (PCA)


Long-term treatment with spermidine increases health span of middle-aged Sprague-Dawley male rats.


Keywords

  • Autophagy
  • Behavior
  • Longevity
  • Middle-aged rats
  • Neuroinflammation
  • Spermidine


Meta-analysis of human prefrontal cortex reveals activation of GFAP and decline of synaptic transmission in the aging brain.


Keywords

  • Aging
  • Meta-analysis
  • Prefrontal cortex
  • Sex-specific
  • Transcriptome


Astroglial biotin deprivation under endoplasmic reticulum stress uncouples BCAA-mTORC1 role in lipid synthesis to prolong autophagy inhibition in the aging brain.


Keywords

  • BCAA
  • ER stress
  • aging
  • autophagy
  • lipogenesis
  • mTORC1


Long-lived mice with reduced growth hormone signaling have a constitutive upregulation of hepatic chaperone-mediated autophagy.


Keywords

  • Aging
  • chaperone-mediated autophagy
  • endocrine control of autophagy
  • endocrine signaling
  • growth hormone


Lipopolysaccharide exposure during late embryogenesis triggers and drives Alzheimer-like behavioral and neuropathological changes in CD-1 mice.


Keywords

  • Alzheimer's disease
  • aging
  • lipopolysaccharide
  • memory
  • mice


Increased levels of Aβ42 decrease the lifespan of ob/ob mice with dysregulation of microglia and astrocytes.


MeSH Terms

  • Alzheimer Disease
  • Amyloid beta-Peptides
  • Animals
  • Astrocytes
  • Gene Knock-In Techniques
  • Longevity
  • Mice
  • Mice, Knockout
  • Mice, Obese
  • Microglia
  • Peptide Fragments

Keywords

  • Alzheimer's disease
  • astrocytes
  • diabetes
  • lifespan
  • microglia
  • obesity


Selective brain neuronal and glial losses without changes in GFAP immunoreactivity: Young versus mature adult Wistar rats.


MeSH Terms

  • Aging
  • Animals
  • Brain
  • Glial Fibrillary Acidic Protein
  • Male
  • Neuroglia
  • Neurons
  • Rats
  • Rats, Wistar

Keywords

  • Ageing
  • Astrocytes
  • GFAP
  • Glia
  • Neurons

GGCT[править]

Blockade of γ-Glutamylcyclotransferase Enhances Docetaxel Growth Inhibition of Prostate Cancer Cells.


MeSH Terms

  • Antineoplastic Agents
  • Apoptosis
  • Cell Line, Tumor
  • Cell Proliferation
  • Cellular Senescence
  • Docetaxel
  • Enzyme Inhibitors
  • Gene Expression
  • Humans
  • Immunohistochemistry
  • Male
  • Prostatic Neoplasms
  • RNA, Small Interfering
  • gamma-Glutamylcyclotransferase

Keywords

  • docetaxel
  • pro-GA
  • prostate cancer cells
  • senescence
  • γ-glutamylcyclotransferase

GHR[править]

Tissue-Specific GHR Knockout Mice: An Updated Review.


Keywords

  • aging
  • growth hormone
  • longevity
  • metabolism
  • mice

GHRH[править]

Physiological and metabolic features of mice with CRISPR/Cas9-mediated loss-of-function in growth hormone-releasing hormone.


Keywords

  • CRISPR
  • GHRH
  • aging
  • lifespan
  • metabolism


Transcriptomic and metabolomic profiling of long-lived growth hormone releasing hormone knock-out mice: evidence for altered mitochondrial function and amino acid metabolism.


Keywords

  • aging
  • growth hormone
  • metabolite
  • mouse
  • transcriptomics

GIP[править]

Absence of GIP secretion alleviates age-related obesity and insulin resistance.


MeSH Terms

  • Adiponectin
  • Adipose Tissue
  • Age Factors
  • Animals
  • Diet
  • Diet, High-Fat
  • Enteroendocrine Cells
  • Gastric Inhibitory Polypeptide
  • Gene Expression
  • Glucose Tolerance Test
  • Insulin
  • Insulin Resistance
  • Leptin
  • Male
  • Mice, Inbred C57BL
  • Mice, Knockout
  • Mice, Transgenic
  • Obesity

Keywords

  • GIP
  • aging
  • incretin
  • obesity

GIT2[править]

Multidimensional informatic deconvolution defines gender-specific roles of hypothalamic GIT2 in aging trajectories.


MeSH Terms

  • Aging
  • Animals
  • Cluster Analysis
  • Computational Biology
  • Female
  • GTPase-Activating Proteins
  • Hypothalamus
  • Longevity
  • Male
  • Mice
  • Mice, Inbred C57BL
  • RNA
  • Sex Characteristics
  • Signal Transduction
  • Transcriptome

Keywords

  • Aging
  • Female
  • GIT2
  • Hypothalamus
  • Longevity

GJC2[править]

Zebrafish brain RNA sequencing reveals that cell adhesion molecules are critical in brain aging.


Keywords

  • Brain aging
  • Cell adhesion molecules
  • RNA sequencing
  • Zebrafish

GK[править]

Progression of diabetic kidney disease in T2DN rats.


MeSH Terms

  • Aging
  • Albuminuria
  • Animals
  • Blood Glucose
  • Diabetes Mellitus, Type 2
  • Diabetic Nephropathies
  • Disease Progression
  • Hypertrophy
  • Kidney Glomerulus
  • Male
  • Membrane Proteins
  • Organ Size
  • Polyuria
  • Rats
  • Rats, Wistar
  • Renin-Angiotensin System
  • Water-Electrolyte Imbalance

Keywords

  • diabetic glomerular disease
  • diabetic nephropathy
  • podocyte pathology
  • renin-angiotensin-aldosterone system
  • scanning ion microscopy
  • type 2 diabetic nephropathy

GNAQ[править]

GNAQ expression initiated in multipotent neural crest cells drives aggressive melanoma of the central nervous system.


MeSH Terms

  • Aging
  • Animals
  • Central Nervous System Neoplasms
  • Disease Models, Animal
  • Disease Progression
  • Embryonic Development
  • Female
  • GTP-Binding Protein alpha Subunits, Gq-G11
  • Male
  • Melanocytes
  • Melanoma
  • Meningeal Neoplasms
  • Mice, Transgenic
  • Multipotent Stem Cells
  • Mutation
  • Neoplasm Invasiveness
  • Neural Crest
  • Nevus
  • Skin Neoplasms
  • Uveal Neoplasms

Keywords

  • GNAQ
  • Plp1
  • blue nevus
  • leptomeningeal melanocytoma
  • uveal melanoma

GNE[править]

Aberrant mitochondrial morphology and function associated with impaired mitophagy and DNM1L-MAPK/ERK signaling are found in aged mutant Parkinsonian LRRK2 mice.


Keywords

  • Aging
  • Dnm1l/DRP1
  • SQSTM1/p62
  • knockin mice
  • macroautophagy
  • mitochondria dysfunction
  • mitochondrial fission
  • mitophagy
  • parkinson disease
  • ubiquitination

GPC1[править]

Decreased expression of GPC1 in human skin keratinocytes and epidermis during ageing.


MeSH Terms

  • Adult
  • Aged
  • Aged, 80 and over
  • Aging
  • Cell Proliferation
  • Cells, Cultured
  • Epidermis
  • Female
  • Fibroblast Growth Factor 2
  • Gene Expression Regulation
  • Glypicans
  • Humans
  • Keratinocytes
  • Middle Aged
  • RNA, Messenger
  • Signal Transduction
  • Skin
  • Young Adult

Keywords

  • Ageing
  • Epidermis
  • Glypican 1
  • Human skin
  • Keratinocytes

GPI[править]

Blood factors transfer beneficial effects of exercise on neurogenesis and cognition to the aged brain.


MeSH Terms

  • Aging
  • Animals
  • Blood Circulation
  • Brain
  • Cognition
  • Cognitive Dysfunction
  • Glycosylphosphatidylinositols
  • Liver
  • Mice
  • Neurogenesis
  • Phospholipase D
  • Physical Conditioning, Animal
  • Regeneration
  • Signal Transduction

GPR6[править]

Accelerated Epigenetic Aging and Methylation Disruptions Occur in Human Immunodeficiency Virus Infection Prior to Antiretroviral Therapy.


Keywords

  • HIV
  • aging
  • epigenetics
  • methylation

GPT[править]

Brain Structural-Behavioral Correlates Underlying Grooved Pegboard Test Performance Across Lifespan.


Keywords

  • aging
  • gray matter
  • visuomotor function
  • white matter

GPX1[править]

Glutathione peroxidase-1 overexpression reduces oxidative stress, and improves pathology and proteome remodeling in the kidneys of old mice.


Keywords

  • glutathione peroxidase-1
  • kidney aging
  • mitochondria
  • proteomics
  • reactive oxygen species

GPX3[править]

Long noncoding RNA glutathione peroxidase 3-antisense inhibits lens epithelial cell apoptosis by upregulating glutathione peroxidase 3 expression in age-related cataract.


MeSH Terms

  • Aging
  • Anterior Capsule of the Lens
  • Apoptosis
  • Cataract
  • Cell Line
  • Cell Nucleus
  • Epithelial Cells
  • Glutathione Peroxidase
  • Humans
  • Hydrogen Peroxide
  • Lens, Crystalline
  • RNA, Long Noncoding
  • Up-Regulation

GPX4[править]

l-carnitine supplementation during in vitro culture regulates oxidative stress in embryos from bovine aged oocytes.


MeSH Terms

  • Animals
  • Carnitine
  • Cattle
  • Culture Media
  • Embryo Culture Techniques
  • Female
  • Fertilization in Vitro
  • In Vitro Oocyte Maturation Techniques
  • Oocytes
  • Oxidative Stress

Keywords

  • Bovine
  • Embryo development
  • Oocyte aging
  • l-carnitine


Dietary Selenium Supplementation Ameliorates Female Reproductive Efficiency in Aging Mice.


Keywords

  • GPX4
  • Gpx1
  • Gpx3
  • Selenof
  • apoptosis
  • embryo
  • follicle development
  • ovarian aging
  • selenium
  • selenoprotein

GREM1[править]

GREM1 inhibits osteogenic differentiation, senescence and BMP transcription of adipose-derived stem cells.


Keywords

  • BMP
  • GREM1
  • adipose-derived stem cells (ADSCs)
  • osteogenic differentiation
  • senescence

GREM2[править]

Increase of gremlin 2 with age in human adipose-derived stromal/stem cells and its inhibitory effect on adipogenesis.


Keywords

  • Adipogenic differentiation
  • Adipose-derived stromal/stem stem cells
  • Aging
  • DAPI, 4′,6-diamidino-2-phenylindole
  • FGF, fibroblast growth factor
  • GREM2
  • GREM2 knockdown
  • HE, hematoxylin eosin
  • Individual differences
  • PBS, phosphate buffered Solution
  • PFA, paraformaldehyde
  • TGF-β, transforming growth factor beta

GRID1[править]

Gene discovery for high-density lipoprotein cholesterol level change over time in prospective family studies.


Keywords

  • GWAS
  • HDL-C metabolism
  • Healthy aging
  • Longevity
  • Longitudinal HDL-C change

GRIK2[править]

Senescence of Normal Human Fibroblasts Relates to the Expression of Ionotropic Glutamate Receptor GluR6/Grik2.


Keywords

  • GluR6
  • Grik2
  • Senescence
  • cancer
  • glutamate receptor
  • normal fibroblasts

GRK2[править]

G protein-coupled receptor kinase 2 modifies the ability of Caenorhabditis elegans to survive oxidative stress.


Keywords

  • Aging
  • Caenorhabditis elegans (C. elegans)
  • G protein coupled receptor kinase (GRK)
  • Oxidative stress
  • Resistance
  • Stress response


G protein coupled receptor kinases modulate Caenorhabditis elegans reactions to heat stresses.


Keywords

  • Aging
  • Biological control
  • Caenorhabditis elegans (C. elegans)
  • G protein coupled receptor (GPCR)
  • G protein coupled receptor kinase (GRK)
  • Heat stress
  • Resistance
  • Stress response


Loss of dynamic regulation of G protein-coupled receptor kinase 2 by nitric oxide leads to cardiovascular dysfunction with aging.


MeSH Terms

  • Aging
  • Animals
  • Female
  • G Protein-Coupled Inwardly-Rectifying Potassium Channels
  • Heart
  • Heart Diseases
  • Homeostasis
  • Male
  • Mice
  • Mutation
  • Myocardium
  • Nitric Oxide

Keywords

  • S-nitrosylation
  • cardiac hypertrophy
  • heart disease

GRM3[править]

Profiling gene expression in the human dentate gyrus granule cell layer reveals insights into schizophrenia and its genetic risk.


MeSH Terms

  • Adolescent
  • Adult
  • Aged
  • Aged, 80 and over
  • Aging
  • Bipolar Disorder
  • Dentate Gyrus
  • Depressive Disorder, Major
  • Female
  • Gene Expression Profiling
  • Genetic Predisposition to Disease
  • Genome-Wide Association Study
  • Humans
  • Male
  • Middle Aged
  • Neurons
  • Quantitative Trait Loci
  • Schizophrenia
  • Transcriptome
  • Young Adult

GRN[править]

Stressful development: Integrating endoderm development, stress, and longevity.


Keywords

  • Caenorhabditis elegans
  • Embryonic development
  • Epigenetics inheritance
  • Innate immunity
  • Longevity
  • Pleiotropy
  • Stress


A Scoping Review of the Evidence About the Nurses Improving Care for Healthsystem Elders (NICHE) Program.


Keywords

  • Aging
  • Geriatric nursing
  • Health care professionals
  • Intervention
  • Quality improvement

GSC[править]

[i]mastermind[/i] regulates niche ageing independently of the [i]Notch[/i] pathway in the [i]Drosophila[/i] ovary.


MeSH Terms

  • Aging
  • Animals
  • Cellular Senescence
  • Drosophila Proteins
  • Drosophila melanogaster
  • Female
  • Germ Cells
  • Nuclear Proteins
  • Ovary
  • Receptors, Notch
  • Signal Transduction
  • Stem Cell Niche
  • Transcriptome

Keywords

  • DE-cadherin
  • Drosophila oogenesis
  • Hedgehog
  • mastermind
  • niche ageing
  • reactive oxygen species

GSTM1[править]

The effects of everyday-life exposure to polycyclic aromatic hydrocarbons on biological age indicators.


Keywords

  • Biological aging
  • DNA adduct
  • Mitochondrial DNA copy number
  • Polycyclic aromatic hydrocarbon
  • Structural equation modelling
  • Telomere length

GSTM2[править]

Small Extracellular Vesicles Have GST Activity and Ameliorate Senescence-Related Tissue Damage.


Keywords

  • 4-HNE
  • EV
  • GSH
  • GST
  • ROS
  • SASP
  • aging
  • extracellular vesicles
  • glutathione metabolism
  • glutathione-S-transferase
  • lipid peroxidation
  • rejuvenation
  • senescence
  • senescence-associated secretory phenotype

GUK1[править]

Characterization of the impact of GMP/GDP synthesis inhibition on replicative lifespan extension in yeast.


Keywords

  • Aging
  • GDP
  • GMP
  • Mycophenolic acid
  • Proteasome
  • Replicative lifespan
  • Yeast

GZMK[править]

Comprehensive Profiling of an Aging Immune System Reveals Clonal GZMK CD8 T Cells as Conserved Hallmark of Inflammaging.


Keywords

  • Aging
  • CD8 T cells
  • CITE-seq
  • granzyme K
  • immune system
  • inflammaging
  • single-cell ATAC-sequencing
  • single-cell BCR-sequencing
  • single-cell RNA-sequencing
  • single-cell TCR-sequencing

H2AX[править]

Evaluation of GammaH2AX in Buccal Cells as a Molecular Biomarker of DNA Damage in Alzheimer's Disease in the AIBL Study of Ageing.


Keywords

  • Alzheimer’s disease
  • DNA damage
  • mild cognitive impairment
  • senescence
  • γH2AX


Cisplatin-induced peripheral neuropathy is associated to neuronal senescence-like response.


Keywords

  • cisplatin
  • neuropathy
  • neurotoxicity
  • p21
  • senescence


Guanine Deaminase Stimulates Ultraviolet-induced Keratinocyte Senescence in Seborrhoeic Keratosis via Guanine Metabolites.


Keywords

  • DNA damage
  • UV-induced keratinocyte senescence
  • guanine deaminase
  • reactive oxygen species
  • uric acid
  • seborrhoeic keratosis


Do BRCA1 and BRCA2 gene mutation carriers have a reduced ovarian reserve? Protocol for a prospective observational study.


MeSH Terms

  • Adolescent
  • Adult
  • Aging
  • BRCA1 Protein
  • BRCA2 Protein
  • Female
  • Germ-Line Mutation
  • Heterozygote
  • Humans
  • Immunohistochemistry
  • Middle Aged
  • Observational Studies as Topic
  • Ovarian Follicle
  • Ovarian Reserve
  • Prospective Studies
  • Research Design
  • Young Adult

Keywords

  • BRCA
  • DNA repair
  • fertility
  • follicle
  • germline mutation
  • oocyte


Slower rates of accumulation of DNA damage in leukocytes correlate with longer lifespans across several species of birds and mammals.


MeSH Terms

  • Animals
  • Birds
  • Bottle-Nosed Dolphin
  • Cross-Sectional Studies
  • DNA Damage
  • Goats
  • Leukocytes
  • Longevity
  • Reindeer
  • Turtles
  • Vertebrates

Keywords

  • DNA damage
  • lifespan
  • short telomeres
  • species


Phosphoproteomic analysis reveals plant DNA damage signalling pathways with a functional role for histone H2AX phosphorylation in plant growth under genotoxic stress.


MeSH Terms

  • ATP-Binding Cassette Transporters
  • Aging
  • Arabidopsis
  • Arabidopsis Proteins
  • Cells, Cultured
  • DNA Damage
  • DNA Repair
  • Gene Expression Regulation, Plant
  • Gene Ontology
  • Germination
  • Histones
  • Mass Spectrometry
  • Phosphorylation
  • Proteome
  • Seeds
  • Serine
  • Signal Transduction
  • Stress, Physiological
  • X-Rays

Keywords

  • ATAXIA TELANGIECTASIA MUTATED (ATM)
  • DNA damage response
  • DNA repair
  • phosphorylation
  • seed

HBM[править]

The effects of dietary fatty acids on bone, hematopoietic marrow and marrow adipose tissue in a murine model of senile osteoporosis.


MeSH Terms

  • Adipose Tissue
  • Adiposity
  • Animals
  • Bone Density
  • Bone Marrow
  • Dietary Fats
  • Dietary Supplements
  • Disease Models, Animal
  • Fatty Acids, Omega-3
  • Female
  • Femur
  • Mice
  • Osteoporosis
  • X-Ray Microtomography

Keywords

  • SAMP8 mouse
  • aging
  • fish oil
  • marrow adipose tissue
  • osteoporosis

HBP1[править]

Suppression of p38/HBP1 pathway alleviates hyperosmotic stress-induced senescent progression of chondrocyte senescence.


MeSH Terms

  • Cellular Senescence
  • Chondrocytes
  • Disease Progression
  • High Mobility Group Proteins
  • Humans
  • Osteoarthritis
  • Repressor Proteins
  • Up-Regulation
  • p38 Mitogen-Activated Protein Kinases

Keywords

  • HBP1
  • chondrocyte
  • osmolality stress
  • p38
  • senescence

HCN1[править]

Protein expression changes of HCN1 and HCN2 in hippocampal subregions of gerbils during the normal aging process.


Keywords

  • Aging
  • Dentate gyrus
  • Granule cells
  • HCN channel
  • Hippocampus proper
  • Pyramidal cells

HDAC1[править]

HDAC1 modulates OGG1-initiated oxidative DNA damage repair in the aging brain and Alzheimer's disease.


MeSH Terms

  • Acetylation
  • Aging
  • Alzheimer Disease
  • Animals
  • Astrocytes
  • Base Sequence
  • Benzophenones
  • Brain
  • Cognition
  • Cognition Disorders
  • DNA Damage
  • DNA Glycosylases
  • Down-Regulation
  • Gene Ontology
  • Guanine
  • Histone Deacetylase 1
  • Memory
  • Mice, Inbred C57BL
  • Mice, Knockout
  • Neurons
  • Oxidative Stress
  • Promoter Regions, Genetic

HDAC10[править]

Middle-aged female rats lack changes in histone H3 acetylation in the anterior hypothalamus observed in young females on the day of a luteinizing hormone surge.


MeSH Terms

  • Acetylation
  • Age Factors
  • Animals
  • Estradiol
  • Female
  • Histones
  • Hypothalamus, Anterior
  • Luteinizing Hormone
  • Rats
  • Rats, Sprague-Dawley

Keywords

  • Histone acetylation
  • LH
  • aging
  • histone deacetylases
  • hypothalamus

HDAC2[править]

EEF1A1 deacetylation enables transcriptional activation of remyelination.


MeSH Terms

  • Acetylation
  • Aging
  • Animals
  • Cell Dedifferentiation
  • Cell Nucleus
  • Histone Deacetylase 1
  • Histone Deacetylase 2
  • Lysine Acetyltransferase 5
  • Mice
  • Models, Biological
  • Oligodendroglia
  • Peptide Elongation Factor 1
  • Peripheral Nervous System
  • Recovery of Function
  • Remyelination
  • SOXE Transcription Factors
  • STAT3 Transcription Factor
  • Schwann Cells
  • Theophylline
  • Trans-Activators
  • Transcriptional Activation

HDAC3[править]

Histone deacetylase-3: Friend and foe of the brain.


Keywords

  • Histone deacetylases
  • aging
  • histone deacetylase-3
  • learning and memory
  • neurodegenerative diseases
  • neurodevelopment


Loss of HDAC3 contributes to meiotic defects in aged oocytes.


MeSH Terms

  • Animals
  • Cells, Cultured
  • Cellular Senescence
  • Female
  • Histone Deacetylases
  • Meiosis
  • Mice
  • Mice, Inbred ICR
  • Oocytes

Keywords

  • HDACs
  • aneuploidy
  • maternal aging
  • oocyte quality
  • reproduction

HDAC4[править]

The posttranslational modification of HDAC4 in cell biology: Mechanisms and potential targets.


Keywords

  • HDAC4
  • cell senescence
  • cellular apoptosis and autophagy
  • glucose metabolism
  • inflammation and pathology
  • proliferation and differentiation

HDAC6[править]

Inhibition of HDAC6 Attenuates Diabetes-Induced Retinal Redox Imbalance and Microangiopathy.


Keywords

  • HDAC6
  • diabetic retinopathy
  • oxidative stress
  • retinal endothelial cell senescence
  • retinal endothelial cells
  • tubastatin A

HDC[править]

Induced pluripotency and spontaneous reversal of cellular aging in supercentenarian donor cells.


MeSH Terms

  • Adult
  • Aged, 80 and over
  • Cell Differentiation
  • Cell Line
  • Cellular Reprogramming
  • Cellular Senescence
  • Child
  • Clone Cells
  • Gene Expression Regulation
  • Humans
  • Induced Pluripotent Stem Cells
  • Mesenchymal Stem Cells
  • Telomere Homeostasis
  • Tissue Donors
  • Transcriptome

Keywords

  • Aging
  • Longevity
  • Reprogramming
  • Supercentenarian
  • Telomere
  • iPSC

HES1[править]

A Single-Cell Transcriptomic Atlas of Human Skin Aging.


Keywords

  • HES1
  • KLF6
  • aging
  • fibroblast
  • keratinocyte
  • quercetin
  • senescence
  • single-cell RNA sequencing
  • skin

HFE[править]

Polyphenol Characterization and Skin-Preserving Properties of Hydroalcoholic Flower Extract from [i]Himantoglossum robertianum[/i] (Orchidaceae).


Keywords

  • Himantoglossum robertianum
  • antioxidants
  • collagenase
  • elastase
  • flavonoids
  • keratinocytes
  • skin aging

HGD[править]

High-glucose diets induce mitochondrial dysfunction in Caenorhabditis elegans.


MeSH Terms

  • Animals
  • Caenorhabditis elegans
  • Diet
  • Gene Expression Regulation
  • Glucose
  • Longevity
  • Mitochondria
  • Mitophagy

HGF[править]

Age-related changes in the immunomodulatory effects of human dental pulp derived mesenchymal stem cells on the CD4 T cell subsets.


Keywords

  • Aging
  • CD4 T cell
  • Dental pulp
  • Immunomodulation
  • Mesenchymal stem cell


Hepatocyte growth factor (HGF) and stem cell factor (SCF) maintained the stemness of human bone marrow mesenchymal stem cells (hBMSCs) during long-term expansion by preserving mitochondrial function via the PI3K/AKT, ERK1/2, and STAT3 signaling pathways.


Keywords

  • Hepatocyte growth factor
  • Mitochondrial function
  • Osteogenic differentiation
  • Senescence
  • Stem cell factor
  • Stem cells from human exfoliated deciduous teeth
  • Stemness


Phenytoin sodium-ameliorated gingival fibroblast aging is associated with autophagy.


Keywords

  • aging
  • autophagy
  • gingival fibroblast
  • phenytoin sodium


Impaired integrin α /β -mediated hepatocyte growth factor release by stellate cells of the aged liver.


Keywords

  • aging
  • hepatic stellate cells
  • integrins
  • laminins
  • mechanobiology

HGS[править]

Handgrip strength asymmetry is associated with future falls in older Americans.


Keywords

  • Aging
  • Functional laterality
  • Geriatric assessment
  • Geriatrics
  • Muscle strength dynamometer


Examining Additional Aspects of Muscle Function with a Digital Handgrip Dynamometer and Accelerometer in Older Adults: A Pilot Study.


Keywords

  • aging
  • geriatric assessment
  • muscle strength
  • muscle weakness
  • physical functional performance


The Relationship between Muscular Strength and Depression in Older Adults with Chronic Disease Comorbidity.


Keywords

  • aging
  • depression
  • disease comorbidities
  • muscular strength


Handgrip Strength in the Korean Population: Normative Data and Cutoff Values.


Keywords

  • Aging
  • Hand strength
  • Muscle strength
  • Nutrition surveys
  • Sarcopenia


Handgrip Strength Asymmetry and Weakness Are Associated with Lower Cognitive Function: A Panel Study.


Keywords

  • aging
  • functional laterality
  • geriatric assessment
  • geriatrics
  • muscle strength dynamometer


Handgrip Strength Asymmetry and Weakness are Differentially Associated with Functional Limitations in Older Americans.


MeSH Terms

  • Aged
  • Aged, 80 and over
  • Female
  • Geriatric Assessment
  • Hand Strength
  • Humans
  • Male
  • Middle Aged
  • Muscle Strength
  • Muscle Strength Dynamometer
  • Muscle Weakness
  • Odds Ratio
  • United States

Keywords

  • aging
  • geriatrics
  • muscle strength
  • muscle strength dynamometer
  • nutrition surveys


Absolute and Body Mass Index Normalized Handgrip Strength Percentiles by Gender, Ethnicity, and Hand Dominance in Americans.


Keywords

  • aging
  • epidemiology
  • hand strength
  • human development
  • muscle weakness


Hand grip strength variability during serial testing as an entropic biomarker of aging: a Poincaré plot analysis.


MeSH Terms

  • Aged
  • Aged, 80 and over
  • Aging
  • Biomarkers
  • Cross-Sectional Studies
  • Entropy
  • Female
  • Hand Strength
  • Heart Rate
  • Humans
  • Male

Keywords

  • Aging
  • Entropy
  • Hand grip strength
  • Nonlinear dynamics
  • Poincaré plot
  • Time series


Physical Activity and Fitness in White- and Blue-Collar Retired Men.


MeSH Terms

  • Aged
  • Aged, 80 and over
  • Aging
  • Body Mass Index
  • Exercise
  • Geriatric Assessment
  • Humans
  • Longitudinal Studies
  • Male
  • Men's Health
  • Occupations
  • Physical Fitness
  • Poland
  • Retirement
  • Social Class
  • Surveys and Questionnaires
  • Task Performance and Analysis

Keywords

  • Retirement
  • occupation
  • old men
  • physical activity


Association between Hand Grip Strength and Self-Rated Health in Middle- and Old-Aged Korean Citizens.


Keywords

  • Hand Grip Strength
  • Korean Longitudinal Study of Aging
  • Self-Rated Health


Weakness May Have a Causal Association With Early Mortality in Older Americans: A Matched Cohort Analysis.


Keywords

  • Aging
  • Epidemiology
  • Geriatrics
  • hand strength
  • muscle strength
  • sarcopenia


Associations Between Dietary Patterns and Handgrip Strength: The Korea National Health and Nutrition Examination Survey 2014-2016.


Keywords

  • Dietary patterns
  • Korea National Health and Nutrition Examination Survey
  • aging
  • diet
  • handgrip strength


Effect of relative handgrip strength on cardiovascular disease among Korean adults aged 45 years and older: Results from the Korean Longitudinal Study of Aging (2006-2016).


MeSH Terms

  • Adult
  • Aged
  • Aged, 80 and over
  • Aging
  • Cardiovascular Diseases
  • Female
  • Hand Strength
  • Humans
  • Longitudinal Studies
  • Male
  • Middle Aged
  • Muscle Strength
  • Muscle, Skeletal
  • Republic of Korea
  • Risk Factors

Keywords

  • Cardiovascular disease
  • KLoSA
  • Relative handgrip strength


Weakness and cognitive impairment are independently and jointly associated with functional decline in aging Americans.


MeSH Terms

  • Activities of Daily Living
  • Aged
  • Aging
  • Cognitive Dysfunction
  • Geriatric Assessment
  • Hand Strength
  • Humans
  • Middle Aged

Keywords

  • Dementia
  • Epidemiology
  • Geriatrics
  • Muscle strength
  • Nervous system


Association of phase angle with sarcopenia and its components in physically active older women.


MeSH Terms

  • Aged
  • Cross-Sectional Studies
  • Electric Impedance
  • Female
  • Hand Strength
  • Humans
  • Muscle Strength
  • Sarcopenia
  • Walking Speed

Keywords

  • Aging
  • Bioimpedance
  • Muscle function
  • Muscle mass

HLA-DRB1[править]

The pathophysiology of polymyalgia rheumatica, small pieces of a big puzzle.


Keywords

  • Aging
  • B cell
  • HLA-DR
  • Interleukin-6
  • Polymyalgia rheumatica
  • T cell

HMGA1[править]

Characterization of [i]HMGA1P6[/i] transgenic mouse embryonic fibroblasts.


Keywords

  • CeRNA
  • HMGA1
  • HMGA1P6
  • pseudogenes
  • senescence

HMGA2[править]

4D Genome Rewiring during Oncogene-Induced and Replicative Senescence.


MeSH Terms

  • Cells, Cultured
  • Cellular Senescence
  • Chromatin Assembly and Disassembly
  • DNA (Cytosine-5-)-Methyltransferase 1
  • DNA Methylation
  • Fibroblasts
  • Genome, Human
  • Heterochromatin
  • Humans
  • In Situ Hybridization, Fluorescence
  • Oncogenes

Keywords

  • 3D genome architecture
  • DNMT1
  • Hi-C
  • chromatin compartments
  • gene regulation
  • oncogene-induced senescence
  • replicative senescence
  • senescence


The protective effects of HMGA2 in the senescence process of bone marrow-derived mesenchymal stromal cells.


Keywords

  • bone marrow derived mesenchymal stromal cells (MSCs)
  • high-mobility group AT-hook 2 (HMGA2)
  • regulator of G protein signaling 2 (Rgs2)
  • senescence

HMGB1[править]

Senescent human melanocytes drive skin ageing via paracrine telomere dysfunction.


MeSH Terms

  • Adult
  • Aged
  • Aged, 80 and over
  • Aging
  • Atrophy
  • Cells, Cultured
  • Cellular Senescence
  • Cyclin-Dependent Kinase Inhibitor p16
  • Epidermis
  • Female
  • Humans
  • Male
  • Melanocytes
  • Middle Aged
  • Paracrine Communication
  • Reactive Oxygen Species
  • Receptors, CXCR4
  • Skin
  • Telomere
  • Young Adult

Keywords

SASP

  • melanocytes
  • senescence
  • skin ageing
  • telomeres

HMGCR[править]

Cholesterol Homeostasis: An In Silico Investigation into How Aging Disrupts Its Key Hepatic Regulatory Mechanisms.


Keywords

  • aging
  • cholesterol biosynthesis
  • mathematical model
  • reactive oxygen species
  • systems biology


Artesunate inhibits the mevalonate pathway and promotes glioma cell senescence.


Keywords

  • artesunate
  • distant seeding
  • glioma
  • mevalonate pathway
  • senescence

HOXD8[править]

Single-Cell Transcriptome Analysis Reveals Six Subpopulations Reflecting Distinct Cellular Fates in Senescent Mouse Embryonic Fibroblasts.


Keywords

  • Hoxd8
  • cellular senescence
  • mouse embryonic fibroblasts
  • senescence-associated secretory phenotype
  • single-cell RNA sequencing
  • transcriptomic heterogeneity

HP[править]

A narrative review of highly processed food addiction across the lifespan.


Keywords

  • Adolescence
  • Adulthood
  • Childhood
  • Food addiction
  • Infancy
  • Lifespan
  • Prenatal


Beta Human Papillomavirus 8E6 Attenuates LATS Phosphorylation after Failed Cytokinesis.


MeSH Terms

  • Apoptosis
  • Cell Cycle Proteins
  • Cell Line, Tumor
  • Cell Proliferation
  • Cell Survival
  • Cytochalasin B
  • Cytokinesis
  • DNA Repair
  • E1A-Associated p300 Protein
  • Gene Expression Regulation
  • HCT116 Cells
  • Host-Pathogen Interactions
  • Humans
  • Keratinocytes
  • Oncogene Proteins, Viral
  • Osteoblasts
  • Papillomaviridae
  • Phenotype
  • Phosphorylation
  • Primary Cell Culture
  • Protein-Serine-Threonine Kinases
  • Signal Transduction
  • Transcription Factors
  • Tumor Suppressor Protein p53

Keywords

  • Hippo signaling pathway
  • apoptosis
  • cancer
  • cytokinesis
  • human papillomavirus
  • senescence
  • skin cancer

HPSE[править]

Distribution of heparan sulfate correlated with the expression of heparanase-1 and matrix metalloproteinase-9 in an ovariectomized rats skin.


Keywords

  • aging
  • estrogen
  • extracellular matrix
  • heparan sulfate
  • heparanase-1
  • matrix metalloproteinase-9

HR[править]

Patients with hip fracture and total hip arthroplasty surgery differ in anthropometric, but not cardiovascular screening abnormalities.


Keywords

  • Aging
  • Cardiovascular reactivity
  • Heart rate variability
  • Hip fracture
  • Total hip arthroplasty


Clinical Role of Lung Ultrasound for the Diagnosis and Prognosis of Coronavirus Disease Pneumonia in Elderly Patients: A Pivotal Study.


Keywords

  • Aging
  • Coronavirus disease
  • Elderly
  • Lung ultrasound
  • Severe acute respiratory syndrome-coronavirus-2


The Relationship of Accelerometer-Assessed Standing Time With and Without Ambulation and Mortality: The WHI OPACH Study.


Keywords

  • Accelerometer
  • Longevity
  • Physical activity


Age-related myofiber atrophy in old mice is reversed by ten weeks voluntary high-resistance wheel running.


Keywords

  • Aging
  • Exercise
  • Mouse model
  • Muscle morphology
  • Skeletal muscle
  • Training


Predicted Skeletal Muscle Mass and 4-Year Cardiovascular Disease Incidence in Middle-Aged and Elderly Participants of IKARIA Prospective Epidemiological Study: The Mediating Effect of Sex and Cardiometabolic Factors.


Keywords

  • aging
  • body composition
  • gender
  • heart disease
  • lean mass
  • obesity
  • primary prevention
  • women


Obesity is associated with early hip fracture risk in postmenopausal women: a 25-year follow-up.


Keywords

  • Aging
  • Body mass index
  • Bone mineral density
  • Follow-up study
  • General population
  • Hip fracture
  • Menopause
  • Obesity


ATM inhibition synergizes with fenofibrate in high grade serous ovarian cancer cells.


Keywords

  • Biochemistry
  • Bioinformatics
  • Cancer research
  • Cell biology
  • Cellular metabolism
  • Cellular senescence
  • Drug combinations
  • Homologous recombination
  • Metabolite
  • Molecular biology
  • PPARa


Effectiveness of adjuvant FOLFOX vs 5FU/LV in adults over age 65 with stage II and III colon cancer using a novel hybrid approach.


Keywords

  • aging
  • cancer
  • chemotherapy
  • comparative effectiveness research
  • pharmacoepidemiology


Age, Frailty, and Comorbidity as Prognostic Factors for Short-Term Outcomes in Patients With Coronavirus Disease 2019 in Geriatric Care.


MeSH Terms

  • Age Factors
  • Aged
  • Aged, 80 and over
  • Betacoronavirus
  • COVID-19
  • Comorbidity
  • Coronavirus Infections
  • Female
  • Frail Elderly
  • Geriatrics
  • Humans
  • Male
  • Models, Statistical
  • Outcome Assessment, Health Care
  • Pandemics
  • Pneumonia, Viral
  • Prognosis
  • SARS-CoV-2
  • Survival Analysis
  • Sweden

Keywords

  • COVID-19
  • aging
  • comorbidity
  • frailty
  • geriatrics
  • survival


Clinical and demographic parameters predict the progression from mild cognitive impairment to dementia in elderly patients.


Keywords

  • Aging
  • Cox regression
  • Dementia
  • Follow-up
  • Mild cognitive impairment


Plasma Dehydroepiandrosterone Sulfate and Cardiovascular Disease Risk in Older Men and Women.


Keywords

  • DHEA-S
  • aging
  • heart failure
  • mortality


High intensity interval training combined with L-citrulline supplementation: Effects on physical performance in healthy older adults.


Keywords

  • Aging
  • Body composition
  • Exercise
  • Mobility
  • Nutrition


Associations of blood pressure with risk of injurious falls in old age vary by functional status: A cohort study.


Keywords

  • Aging
  • Blood pressure
  • Falls
  • Injury
  • Swedish National study on Aging and Care in Kungsholmen (SNAC-K)


Epigenetic age acceleration and clinical outcomes in gliomas.


MeSH Terms

  • Adult
  • Aging
  • DNA Methylation
  • Epigenesis, Genetic
  • Female
  • Glioma
  • Humans
  • Male
  • Middle Aged
  • Prognosis
  • Survival Analysis


Do Stairs Inhibit Seniors Who Live on Upper Floors From Going Out?


Keywords

  • active aging
  • activity monitor
  • homebound
  • mobility
  • walk-up buildings


Age-specific acute changes in carotid-femoral pulse wave velocity with head-up tilt.


Keywords

  • arterial function
  • arterial stiffness
  • blood pressure
  • early vascular aging
  • pressure dependence


Pre-frailty status increases the risk of rehospitalization in patients after elective cardiac surgery without complication.


MeSH Terms

  • Aged
  • Cardiac Surgical Procedures
  • Elective Surgical Procedures
  • Female
  • Frailty
  • Humans
  • Male
  • Patient Readmission
  • Postoperative Complications
  • Retrospective Studies
  • Risk

Keywords

  • adverse events
  • aging
  • cardiac surgery
  • frailty
  • rehospitalization


Comparative Performance of Creatinine-Based GFR Estimation Equations in Exceptional Longevity: The Rugao Longevity and Ageing Study.


MeSH Terms

  • Aged, 80 and over
  • Creatinine
  • Female
  • Glomerular Filtration Rate
  • Humans
  • Kidney Function Tests
  • Longevity
  • Male
  • Mortality
  • Predictive Value of Tests
  • Renal Insufficiency
  • Reproducibility of Results
  • Risk Factors

Keywords

  • equation
  • exceptional longevity
  • glomerular filtration rate
  • kidney function
  • mortality


Sex-and race-specific associations of protein intake with change in muscle mass and physical function in older adults: the Health, Aging, and Body Composition (Health ABC) Study.


MeSH Terms

  • Aged
  • Aged, 80 and over
  • Aging
  • Biomass
  • Body Composition
  • Body Weight
  • Dietary Proteins
  • Female
  • Humans
  • Independent Living
  • Male
  • Muscle Development
  • Muscle Strength
  • Muscles
  • Prospective Studies
  • Sex Factors

Keywords

  • appendicular lean body mass
  • community-dwelling
  • gait speed
  • mobility limitation
  • old age
  • optimal intake
  • physical performance
  • spline functions


Deterioration of bone microstructure by aging and menopause in Japanese healthy women: analysis by HR-pQCT.


MeSH Terms

  • Absorptiometry, Photon
  • Adult
  • Aged
  • Aging
  • Asian Continental Ancestry Group
  • Bone Density
  • Bone and Bones
  • Cancellous Bone
  • Cortical Bone
  • Female
  • Finite Element Analysis
  • Humans
  • Japan
  • Linear Models
  • Menopause
  • Middle Aged
  • Porosity
  • Tomography, X-Ray Computed

Keywords

  • Bone microstructure
  • Estimated bone strength
  • High resolution peripheral quantitative CT (HR-pQCT)
  • Japanese women
  • Non-metric trabecular parameter


Association between Low Protein Intake and Mortality in Patients with Type 2 Diabetes.


Keywords

  • aging
  • diabetes
  • mortality
  • nutritional support
  • protein intake


CAUSES, mortality rates and risk factors of death in community-dwelling Europeans aged 50 years and over: Results from the Survey of Health, Ageing and Retirement in Europe 2013-2015.


MeSH Terms

  • Activities of Daily Living
  • Aged
  • Aging
  • Cohort Studies
  • Europe
  • Humans
  • Independent Living
  • Male
  • Middle Aged
  • Mortality
  • Proportional Hazards Models
  • Prospective Studies
  • Retirement
  • Risk Factors
  • Surveys and Questionnaires

Keywords

  • Aging
  • Comorbidity
  • Depressive symptoms
  • Diseases
  • Mortality risk


Estimation of Wave Condition Number From Pressure Waveform Alone and Its Changes With Advancing Age in Healthy Women and Men.


Keywords

  • arterial wave reflection
  • cardiovascular biomarker
  • optimum cardiovascular function
  • vascular aging
  • wave condition number


Extended in vitro culture of primary human mesenchymal stem cells downregulates Brca1-related genes and impairs DNA double-strand break recognition.


Keywords

BRCA1

  • DNA repair
  • cellular aging
  • homologous recombination
  • mesenchymal stem cells


Effect of artificial dawn light on cardiovascular function, alertness, and balance in middle-aged and older adults.


Keywords

  • aging
  • alertness
  • balance
  • blood pressure
  • heart rate
  • heart rate variability
  • light
  • sleep inertia


Heart Rate Performance Curve Is Dependent on Age, Sex, and Performance.


Keywords

  • aging
  • heart rate deflection
  • intensity prescription
  • maximal heart rate
  • sex differences
  • ß1-receptor sensitivity


Physical activity trajectories, mortality, hospitalization, and disability in the Toledo Study of Healthy Aging.


Keywords

  • Adverse outcomes
  • Healthy aging
  • Mortality
  • Older adults
  • Physical activity
  • Trajectories


U-Shaped Association of Plasma Testosterone, and no Association of Plasma Estradiol, with Incidence of Fractures in Men.


Keywords

  • estradiol
  • fracture
  • male aging
  • osteoporosis
  • sex hormone-binding globulin
  • testosterone


Pregnancy-Related Bone Mineral and Microarchitecture Changes in Women Aged 30 to 45 Years.


Keywords

  • AGING
  • ANALYSIS/QUANTITATION OF BONE
  • BONE QCT/μCT
  • EPIDEMIOLOGY
  • GENERAL POPULATION STUDIES


Analysis of the world record time for combined father and son marathon.


Keywords

  • V̇o2max
  • aerobic exercise
  • aging
  • endurance
  • oxygen consumption
  • running


Age-related reductions in heart rate variability do not worsen during exposure to humid compared to dry heat: A secondary analysis.


Keywords

  • Aging
  • autonomic nervous system
  • heat stress
  • parasympathetic nervous system
  • relative humidity
  • sympathetic nervous system


Efficacy and Safety of Dapagliflozin in the Elderly: Analysis From the DECLARE-TIMI 58 Study.


MeSH Terms

  • Adult
  • Age Factors
  • Aged
  • Aged, 80 and over
  • Aging
  • Benzhydryl Compounds
  • Cardiovascular System
  • Diabetes Mellitus, Type 2
  • Diabetic Ketoacidosis
  • Female
  • Glucosides
  • Humans
  • Hypoglycemia
  • Hypoglycemic Agents
  • Incidence
  • Kidney
  • Male
  • Middle Aged
  • Sodium-Glucose Transporter 2 Inhibitors
  • Survival Analysis
  • Treatment Outcome
  • Urinary Tract Infections


Validity of Prediction Equations of Maximal Heart Rate in Physically Active Female Adolescents and the Role of Maturation.


MeSH Terms

  • Adolescent
  • Aging
  • Body Mass Index
  • Exercise
  • Exercise Test
  • Female
  • Heart Rate
  • Humans

Keywords

  • cardiac rate
  • exercise prescription
  • exercise testing
  • prediction equations
  • training zones
  • volleyball


Base excision repair but not DNA double-strand break repair is impaired in aged human adipose-derived stem cells.


MeSH Terms

  • Adipose Tissue
  • Adult
  • Aging
  • DNA Breaks, Double-Stranded
  • DNA End-Joining Repair
  • DNA Repair
  • Humans
  • Middle Aged
  • Recombinational DNA Repair
  • Stem Cells
  • Up-Regulation
  • X-ray Repair Cross Complementing Protein 1
  • Young Adult

Keywords

  • XRCC1
  • adipose-derived stem cells
  • base excision repair
  • genome integrity
  • human aging


Urban-Rural Differences in Hip Fracture Mortality: A Nationwide NOREPOS Study.


Keywords

  • AGING
  • EPIDEMIOLOGY
  • GENERAL POPULATION STUDIES
  • OSTEOPOROSIS
  • STATISTICAL METHODS


Malnutrition as a Strong Predictor of the Onset of Sarcopenia.


MeSH Terms

  • Aged
  • Aging
  • Cohort Studies
  • Female
  • Humans
  • Independent Living
  • Male
  • Malnutrition
  • Proportional Hazards Models
  • Prospective Studies
  • Risk Factors
  • Sarcopenia

Keywords

  • EWGSOP2
  • GLIM
  • SarcoPhAge
  • malnutrition
  • sarcopenia


Acclimation to a thermoneutral environment abolishes age-associated alterations in heart rate and heart rate variability in conscious, unrestrained mice.


Keywords

  • Aging
  • Cardiac autonomic modulation
  • Heart rate
  • Heart rate variability
  • Thermoneutrality


Long-term dementia risk prediction by the LIBRA score: A 30-year follow-up of the CAIDE study.


MeSH Terms

  • Aged
  • Apolipoproteins E
  • Cognitive Dysfunction
  • Dementia
  • Female
  • Follow-Up Studies
  • Genetic Predisposition to Disease
  • Humans
  • Life Style
  • Male
  • Protective Factors
  • Risk Assessment
  • Risk Factors

Keywords

  • cognitive aging
  • cohort study
  • dementia
  • epidemiology
  • lifestyle
  • prevention
  • risk factors


Kidney function and its association to imminent, short- and long-term fracture risk-a longitudinal study in older women.


Keywords

  • Aging
  • Bone mineral density
  • Chronic kidney disease
  • Estimated glomerular filtration rate
  • Fracture
  • Women


Oxidatively Damaged DNA/RNA and 8-Isoprostane Levels Are Associated With the Development of Type 2 Diabetes at Older Age: Results From a Large Cohort Study.


MeSH Terms

  • Age of Onset
  • Aged
  • Aging
  • Biomarkers
  • Cohort Studies
  • DNA
  • DNA Damage
  • Diabetes Mellitus, Type 2
  • Dinoprost
  • Female
  • Follow-Up Studies
  • Germany
  • Humans
  • Incidence
  • Lipid Peroxidation
  • Male
  • Middle Aged
  • Oxidation-Reduction
  • Oxidative Stress
  • RNA


Associations of vigorous physical activity with all-cause, cardiovascular and cancer mortality among 64 913 adults.


Keywords

  • cardio-protection
  • exercise
  • longevity
  • non-communicable diseases
  • physical activity


Reduced cerebrovascular and cardioventilatory responses to intermittent hypoxia in elderly.


MeSH Terms

  • Adult
  • Aged
  • Aging
  • Blood Pressure
  • Brain
  • Cerebrovascular Circulation
  • Female
  • Heart Rate
  • Humans
  • Hypoxia
  • Male
  • Pulmonary Ventilation
  • Ultrasonography, Doppler, Transcranial
  • Young Adult

Keywords

  • Aging
  • Arterial oxygen saturation
  • Cerebral blood flow
  • Cerebral tissue oxygenation
  • Heart rate
  • Hypoxemia
  • Ventilation


Vestibulo-sympathetic reflex in patients with bilateral vestibular loss.


MeSH Terms

  • Aging
  • Bilateral Vestibulopathy
  • Female
  • Humans
  • Male
  • Middle Aged
  • Reflex, Abnormal
  • Sympathetic Nervous System

Keywords

  • bilateral vestibular loss
  • compensation
  • multisensory integration
  • otolithic system
  • vestibulo-sympathetic reflex


Heart rate and blood pressure in male Ts65Dn mice: a model to investigate cardiovascular responses in Down syndrome.


MeSH Terms

  • Animals
  • Autonomic Nervous System
  • Blood Pressure
  • Circadian Rhythm
  • Down Syndrome
  • Heart Rate
  • Male
  • Mice
  • Mice, Inbred C57BL
  • Vascular Stiffness

Keywords

  • Aging
  • arterial stiffness
  • autonomic nervous system
  • circadian
  • pulse wave velocity
  • spectral analysis


Body weight at 10 years of age and change in body composition between 8 and 10 years of age were related to survival in a longitudinal study of 39 Labrador retriever dogs.


MeSH Terms

  • Adipose Tissue
  • Animals
  • Body Composition
  • Body Weight
  • Dogs
  • Longevity
  • Longitudinal Studies
  • Survival Analysis

Keywords

  • Cohort
  • Cox
  • DEXA
  • Dogs
  • Fat mass
  • Healthspan
  • Lean mass
  • Lean to fat ratio
  • Longevity
  • Sarcopenia


Dietary diversity offsets the adverse mortality risk among older indigenous Taiwanese.


MeSH Terms

  • Aged
  • Aged, 80 and over
  • Asian Continental Ancestry Group
  • Diet
  • Female
  • Health Surveys
  • Humans
  • Indigenous Peoples
  • Longevity
  • Male
  • Mortality
  • Nutrition Surveys
  • Nutritional Status
  • Risk Factors
  • Taiwan


Independent and joint effects of vascular and cardiometabolic risk factor pairs for risk of all-cause dementia: a prospective population-based study.


MeSH Terms

  • Aged
  • Aged, 80 and over
  • Aging
  • Apolipoprotein E4
  • Cognitive Dysfunction
  • Dementia
  • Exercise
  • Female
  • Heart Failure
  • Heterozygote
  • Humans
  • Hypertension
  • Male
  • Pennsylvania
  • Proportional Hazards Models
  • Prospective Studies
  • Risk Factors
  • Stroke

Keywords

  • Alzheimer‘s disease (AD)
  • apolipoprotein E (APOE)
  • cerebral vascular disease (CVD)
  • dementia
  • epidemiology


Work Ability and Job Survival: Four-Year Follow-Up.


MeSH Terms

  • Adult
  • Brazil
  • Employment
  • Female
  • Follow-Up Studies
  • Hospitals
  • Humans
  • Male
  • Proportional Hazards Models
  • Work Capacity Evaluation

Keywords

  • aging
  • healthcare worker
  • life course
  • longitudinal studies
  • prolonged work career
  • work ability


Predictivity of bioimpedance phase angle for incident disability in older adults.


Keywords

  • Aging
  • Body composition
  • Cellular health
  • Muscle mass
  • Nutrition

HRAS[править]

How do combinations of unhealthy behaviors relate to attitudinal factors and subjective health among the adult population in the Netherlands?


MeSH Terms

  • Adult
  • Alcohol Drinking
  • Attitude to Health
  • Cluster Analysis
  • Diagnostic Self Evaluation
  • Diet, Healthy
  • Exercise
  • Female
  • Health Risk Behaviors
  • Humans
  • Life Expectancy
  • Life Style
  • Logistic Models
  • Male
  • Middle Aged
  • Netherlands
  • Prevalence
  • Sedentary Behavior
  • Smoking
  • Surveys and Questionnaires
  • Young Adult

Keywords

  • Clustering risk attitude
  • Health behaviours
  • Subjective health
  • Time orientation


Elucidating Proteoform Dynamics Underlying the Senescence Associated Secretory Phenotype.


Keywords

  • proteoform
  • quantitative proteomics
  • secretome
  • senescence
  • top-down proteomics

HS2ST1[править]

Whole Genome Analysis of the Red-Crowned Crane Provides Insight into Avian Longevity.


MeSH Terms

  • Animals
  • Avian Proteins
  • Birds
  • Endangered Species
  • Immunity
  • Longevity
  • Polymorphism, Genetic
  • Species Specificity
  • Transcriptome
  • Whole Genome Sequencing

Keywords

  • genome
  • longevity
  • red-crowned crane

HSF1[править]

A Mitochondrial Stress-Specific Form of HSF1 Protects against Age-Related Proteostasis Collapse.


Keywords

  • HSF1
  • PP2A
  • aging
  • mitochondria
  • molecular chaperones
  • protein aggregation
  • proteostasis
  • stress responses


Heat shock factor 1-mediated transcription activation of Omi/HtrA2 induces myocardial mitochondrial apoptosis in the aging heart.


MeSH Terms

  • Aging
  • Animals
  • Apoptosis
  • Heat Shock Transcription Factors
  • High-Temperature Requirement A Serine Peptidase 2
  • Male
  • Mice
  • Mice, Inbred C57BL
  • Mitochondria, Heart
  • Myocytes, Cardiac
  • NIH 3T3 Cells
  • Transcriptional Activation
  • Up-Regulation

Keywords

  • Omi/HtrA2
  • age-related pathology
  • cardiovascular
  • mitochondria
  • transcriptional regulation


Multifactorial Attenuation of the Murine Heat Shock Response With Age.


Keywords

  • Aging
  • HSF1
  • Stress

HSPA1A[править]

Vitamin D3 treatment regulates apoptosis, antioxidant defense system, and DNA integrity in the epididymal sperm of an aged rat model.


MeSH Terms

  • Aging
  • Animals
  • Antioxidants
  • Apoptosis
  • Cholecalciferol
  • Epididymis
  • Male
  • Rats
  • Rats, Wistar
  • Spermatozoa

Keywords

  • aging
  • apoptosis
  • oxidative stress
  • sperm

HSPA1L[править]

Melatonin suppresses senescence-derived mitochondrial dysfunction in mesenchymal stem cells via the HSPA1L-mitophagy pathway.


Keywords

  • HSPA1L
  • melatonin
  • mesenchymal stem cells
  • mitochondria
  • mitophagy
  • replicative senescence

HTT[править]

Biological Aging and the Cellular Pathogenesis of Huntington's Disease.


Keywords

  • Biological aging
  • DNA damage
  • Huntington’s disease
  • cellular aging
  • microsatellite instability
  • neurodegeneration
  • oxidative stress
  • proteostasis
  • telomere

ICE1[править]

ATBS1-INTERACTING FACTOR 2 negatively regulates dark- and brassinosteroid-induced leaf senescence through interactions with INDUCER OF CBF EXPRESSION 1.


Keywords

  • ATBS1-INTERACTING FACTOR 2 (AIF2)
  • Arabidopsis
  • C-REPEAT BINDING FACTOR (CBF)
  • INDUCER OF CBF EXPRESSION 1 (ICE1)
  • PHYTOCHROME-INTERACTING FACTORS (PIFs)
  • basic helix–loop–helix (bHLH)
  • brassinosteroid (BR)
  • leaf senescence

IDE[править]

Dendrobium nobile Lindl. Alkaloids Ameliorate Cognitive Dysfunction in Senescence Accelerated SAMP8 Mice by Decreasing Amyloid-β Aggregation and Enhancing Autophagy Activity.


Keywords

  • Aging
  • Dendrobium nobile Lindl. alkaloid (DNLA)
  • amyloid-β
  • autophagy
  • metformin
  • senescence accelerated mouse prone 8 (SAMP8)

IDH2[править]

Reactive oxygen species-mediated senescence is accelerated by inhibiting Cdk2 in Idh2-deficient conditions.


MeSH Terms

  • Animals
  • Cellular Senescence
  • Cyclin-Dependent Kinase 2
  • Cyclin-Dependent Kinase Inhibitor p21
  • Embryo, Mammalian
  • Fibroblasts
  • Isocitrate Dehydrogenase
  • Mice
  • Mice, Knockout
  • NIH 3T3 Cells
  • Reactive Oxygen Species

Keywords

  • cell cycle
  • cyclin-dependent kinase 2 (Cdk2)
  • isocitrate dehydrogenase 2 (IDH2)
  • reactive oxygen species (ROS)
  • senescence

IDS[править]

Effect of immediate dentine sealing on the aging and fracture strength of lithium disilicate inlays and overlays.


Keywords

  • Aging
  • Ceramic
  • Fracture strength
  • Immediate dentin sealing
  • Inlay
  • Overlay

IFI27[править]

Ultraviolet B irradiation-induced keratinocyte senescence and impaired development of 3D epidermal reconstruct.


Keywords

  • epidermis
  • keratinocytes
  • reactive oxygen species
  • senescence
  • skin aging
  • ultraviolet radiation

IGF1[править]

Genetic differences and longevity-related phenotypes influence lifespan and lifespan variation in a sex-specific manner in mice.


Keywords

  • IGF1
  • antagonistic gene
  • female sexual maturation
  • lifespan variation
  • maximum lifespan
  • sex difference in lifespan


17α-estradiol modulates IGF1 and hepatic gene expression in a sex-specific manner.


Keywords

  • 17α-estradiol
  • aging
  • growth hormone
  • insulin
  • insulin-like growth factor-1
  • liver


Pan-mammalian analysis of molecular constraints underlying extended lifespan.


Keywords

  • RERconverge
  • computational biology
  • evolution
  • genetics
  • genomics
  • longevity
  • mammals
  • phylogenomics
  • systems biology


17α-Estradiol promotes ovarian aging in growth hormone receptor knockout mice, but not wild-type littermates.


Keywords

  • Follicles
  • Ovarian aging
  • Ovarian reserve
  • Reproductive lifespan

IGF1R[править]

Comparison of mitochondrial transplantation by using a stamp-type multineedle injector and platelet-rich plasma therapy for hair aging in naturally aging mice.


Keywords

  • Aging mice
  • Hair growth
  • Mitochondrial transplantation
  • Pep-1
  • Platelet-rich plasma

IGFBP1[править]

Role of IGFBP1 in the senescence of vascular endothelial cells and severity of aging‑related coronary atherosclerosis.


MeSH Terms

  • Adult
  • Aged
  • Aged, 80 and over
  • Aging
  • Atherosclerosis
  • Cells, Cultured
  • Cellular Senescence
  • Coronary Artery Disease
  • Coronary Vessels
  • Down-Regulation
  • Endothelial Cells
  • Female
  • Humans
  • Insulin-Like Growth Factor Binding Protein 1
  • Jagged-1 Protein
  • Male
  • Middle Aged
  • Signal Transduction
  • Up-Regulation

IGFBP2[править]

Intracellular Insulin-like growth factor binding protein 2 (IGFBP2) contributes to the senescence of keratinocytes in psoriasis by stabilizing cytoplasmic p21.


Keywords

  • insulin-like growth factor binding protein 2
  • keratinocytes
  • p21CIP1/WAF1
  • psoriasis
  • senescence

IGFBP3[править]

Cellular and Molecular Biomarkers Indicate Premature Aging in Pseudoxanthoma Elasticum Patients.


Keywords

  • CCL11
  • GDF11
  • IGF1
  • IGFBP
  • aging
  • pseudoxanthoma elasticum


Paracrine senescence of human endometrial mesenchymal stem cells: a role for the insulin-like growth factor binding protein 3.


Keywords

  • IGFBP3
  • endocytosis
  • endometrial stem cells
  • paracrine senescence
  • secretome

IGFBP4[править]

Quantitative iTRAQ-based proteomic analysis of differentially expressed proteins in aging in human and monkey.


MeSH Terms

  • Adult
  • Aged
  • Aged, 80 and over
  • Aging
  • Animals
  • Cognition
  • Female
  • Gene Expression Regulation
  • Gene Regulatory Networks
  • Haplorhini
  • Humans
  • Insulin-Like Growth Factor Binding Protein 4
  • Male
  • Mice
  • Proteomics

Keywords

  • Cognitive dysfunction
  • IGFBP4
  • Plasma
  • Quantitative proteomics
  • iTRAQ

IGFBP7[править]

Reprogramming of human fibroblasts into osteoblasts by insulin-like growth factor-binding protein 7.


Keywords

  • IGFBP7
  • IL-6
  • human fibroblast
  • osteoblast
  • reprogramming
  • senescence

IHH[править]

Indian Hedgehog regulates senescence in bone marrow-derived mesenchymal stem cell through modulation of ROS/mTOR/4EBP1, p70S6K1/2 pathway.


Keywords

  • Indian hedgehog
  • aging
  • differentiation
  • mammalian target of rapamycin
  • mesenchymal stem cell

IL10[править]

The beneficial effect of physical exercise on inflammatory makers in older individuals.


Keywords

  • IL-6 expression
  • Inflammatory markers
  • aerobic exercise
  • aging
  • plasma IL-6 levels
  • resistance training


Astrocyte senescence may drive alterations in GFAPα, CDKN2A p14 , and TAU3 transcript expression and contribute to cognitive decline.


MeSH Terms

  • Aged
  • Alternative Splicing
  • Astrocytes
  • Cells, Cultured
  • Cellular Senescence
  • Cognitive Dysfunction
  • Cytokines
  • Gene Expression
  • Glial Fibrillary Acidic Protein
  • Humans
  • Matrix Metalloproteinases
  • Transcription, Genetic
  • Tumor Suppressor Protein p14ARF
  • tau Proteins

Keywords

  • Alternative splicing
  • Gene expression
  • Neurodegenerative disease
  • Senescence


Dietary Spray-Dried Porcine Plasma Prevents Cognitive Decline in Senescent Mice and Reduces Neuroinflammation and Oxidative Stress.


MeSH Terms

  • Animals
  • Cognition Disorders
  • Encephalitis
  • Male
  • Mice
  • Oxidative Stress
  • Plasma
  • Swine

Keywords

  • aging
  • cognitive decline
  • dietary supplementation
  • neuroinflammation
  • spray-dried animal plasma

IL15[править]

Moderate physical activity associated with a higher naïve/memory T-cell ratio in healthy old individuals: potential role of IL15.


Keywords

  • T cells
  • ageing
  • immune senescence
  • older people
  • physical activity

IL1A[править]

IL1B triggers inflammatory cytokine production in bovine oviduct epithelial cells and induces neutrophil accumulation via CCL2.


Keywords

  • CCL2
  • cellular senescence
  • inflammaging
  • senescence-associated secretory phenotype

IL2[править]

Impact of Aging on the Phenotype of Invariant Natural Killer T Cells in Mouse Thymus.


Keywords

  • IL2
  • aging
  • invariant natural killer T cells
  • thymus
  • transcriptome

IL6[править]

Basic immunology may lead to translational therapeutic rationale: SARS-CoV-2 and rheumatic diseases.


MeSH Terms

  • Adaptive Immunity
  • Aged
  • Antirheumatic Agents
  • COVID-19
  • Comorbidity
  • Coronavirus Infections
  • Disease Outbreaks
  • Female
  • Humans
  • Hydroxychloroquine
  • Immunity, Innate
  • Immunologic Factors
  • Immunosuppressive Agents
  • Italy
  • Male
  • Middle Aged
  • Pandemics
  • Pneumonia, Viral
  • Rheumatic Diseases
  • Risk Assessment
  • Severe Acute Respiratory Syndrome

Keywords

  • COVID-19
  • SARS-CoV-2
  • geriatrics
  • pathophysiology
  • pediatrics
  • rheumatology


ATM-deficient neural precursors develop senescence phenotype with disturbances in autophagy.


Keywords

  • ATM
  • Ataxia-telangiectasia
  • Autophagy
  • Mitophagy
  • Neural progenitors
  • Oxidative stress
  • Senescence
  • hiPSCs


The microRNA-34a-Induced Senescence-Associated Secretory Phenotype (SASP) Favors Vascular Smooth Muscle Cells Calcification.


Keywords

  • IL6
  • SASP
  • VSMCs
  • inflammaging
  • senescence
  • vascular calcification


Impact of Influenza on Pneumococcal Vaccine Effectiveness during [i]Streptococcus pneumoniae[/i] Infection in Aged Murine Lung.


Keywords

  • Streptococcus pneumoniae
  • aging
  • influenza
  • vaccine effectiveness
  • viral immune imprinting


Patterns of multi-domain cognitive aging in participants of the Long Life Family Study.


Keywords

  • Aging
  • Biomarker
  • Cognition
  • Neuropsychology


Cholest-4,6-Dien-3-One Promote Epithelial-To-Mesenchymal Transition (EMT) in Biliary Tree Stem/Progenitor Cell Cultures In Vitro.


MeSH Terms

  • Biliary Tract
  • Cell Differentiation
  • Cell Proliferation
  • Cells, Cultured
  • Cellular Senescence
  • Cholestenones
  • Epithelial-Mesenchymal Transition
  • Histone Deacetylase 6
  • Humans
  • Interleukin-6
  • Signal Transduction
  • Stem Cells
  • Tissue Donors

Keywords

  • BMP pathway
  • SHH pathway
  • biliary tree stem/progenitor cells (BTSCs)
  • epithelial-to-mesenchymal transition (EMT)
  • primary sclerosing cholangitis (PSC)
  • senescence
  • telomerase


Single xenotransplant of rat brown adipose tissue prolonged the ovarian lifespan of aging mice by improving follicle survival.


MeSH Terms

  • Adipose Tissue, Brown
  • Animals
  • Cellular Senescence
  • Female
  • Longevity
  • Male
  • Mice
  • Ovarian Follicle
  • Ovary
  • Rats
  • Rats, Sprague-Dawley
  • Transplantation, Heterologous

Keywords

  • aging
  • brown adipose tissue (BAT)
  • lifespan
  • mice
  • ovary
  • rat
  • xenotransplant

ILDR1[править]

Genome-wide association meta-analysis identifies five novel loci for age-related hearing impairment.


MeSH Terms

  • Aging
  • Animals
  • Auditory Pathways
  • Female
  • Gene Expression Regulation
  • Genetic Loci
  • Genetic Predisposition to Disease
  • Genome-Wide Association Study
  • Hearing Loss
  • Humans
  • Male
  • Mice
  • Middle Aged
  • Molecular Sequence Annotation
  • Phenotype
  • Reproducibility of Results

IMPACT[править]

Load-dependent modulation of alpha oscillations during working memory encoding and retention in young and older adults.


Keywords

  • EEG
  • alpha oscillations
  • cognitive aging
  • working memory


Using Video Telehealth to Deliver Patient-Centered Collaborative Care: The G-IMPACT Pilot.


Keywords

  • Telehealth
  • aging
  • care coordination
  • home care
  • interdisciplinary
  • medicine
  • older adult
  • video


AGING, HEART RATE VARIABILITY AND METABOLIC IMPACT OF OBESITY.


MeSH Terms

  • Aging
  • Autonomic Nervous System
  • Autonomic Nervous System Diseases
  • Female
  • Heart Rate
  • Humans
  • Male
  • Metabolic Diseases
  • Metabolism
  • Middle Aged
  • Obesity

Keywords

  • Aging
  • Autonomic nervous system
  • Heart rate
  • Obesity, metabolically benign
  • Parasympathetic nervous system
  • Sympathetic nervous system

INS[править]

Melatonin protects INS-1 pancreatic β-cells from apoptosis and senescence induced by glucotoxicity and glucolipotoxicity.


Keywords

  • Melatonin
  • Senescence
  • glucolipotoxicity
  • glucotoxicity
  • pancreatic β-cell


Nicotine triggers islet β cell senescence to facilitate the progression of type 2 diabetes.


MeSH Terms

  • Animals
  • Blotting, Western
  • Calcium
  • Cellular Senescence
  • Diabetes Mellitus, Type 2
  • Disease Progression
  • Dose-Response Relationship, Drug
  • Enzyme-Linked Immunosorbent Assay
  • Glucose
  • Insulin-Secreting Cells
  • Male
  • Mice
  • Mice, Inbred C57BL
  • Nicotine
  • Reactive Oxygen Species
  • Real-Time Polymerase Chain Reaction
  • beta-Galactosidase

Keywords

  • ROS
  • islet β cells
  • nicotine
  • senescence
  • type 2 diabetes

INSL3[править]

Effect of Thyroxine Replacement on Leydig Cell and Sertoli Cell Function in Men with Hypothyroidism.


Keywords

  • Androgen deficiency in aging male
  • arizona sexual experience scale
  • hypothyroidism
  • inhibin B
  • insulin-like factor 3
  • semen analysis
  • sperm motility

IP6K1[править]

The Role of the IGF-1 Signaling Cascade in Muscle Protein Synthesis and Anabolic Resistance in Aging Skeletal Muscle.


Keywords

  • Akt
  • IP6K1
  • aging
  • anabolic resistance
  • mTOR
  • protein
  • resistance exercise
  • sarcopenia

IQGAP1[править]

IQGAP1-dysfunction leads to induction of senescence in human vascular smooth muscle cells.


Keywords

  • Cellular bridges (CBs)
  • IQGAP1
  • Intercellular communication
  • Senescence
  • Tunneling nanotubes (TNTs)
  • Vascular smooth muscle cells (VSMCs)


Hyaluronan-binding protein 1 (HABP1) overexpression triggers induction of senescence in fibroblasts cells.


Keywords

  • F-HABP07
  • HABP1
  • IQGAP1
  • senescence

IRF8[править]

IRF8 induces senescence of lung cancer cells to exert its tumor suppressive function.


MeSH Terms

  • A549 Cells
  • Animals
  • Carcinogenesis
  • Carcinoma, Non-Small-Cell Lung
  • Cell Movement
  • Cell Proliferation
  • Cellular Senescence
  • Gene Expression Regulation, Neoplastic
  • Heterografts
  • Humans
  • Interferon Regulatory Factors
  • Mice
  • Prognosis
  • Signal Transduction
  • Tumor Suppressor Proteins

Keywords

  • IRF8
  • NSCLC
  • cell cycle arrest
  • cell senescence
  • tumor suppresser gene

IRS1[править]

MicroRNA-34a causes ceramide accumulation and effects insulin signaling pathway by targeting ceramide kinase (CERK) in aging skeletal muscle.


Keywords

  • CERK
  • aging muscle
  • insulin signaling pathway
  • miR-34a


Longevity in response to lowered insulin signaling requires glycine N-methyltransferase-dependent spermidine production.


Keywords

  • IGF
  • aging
  • autophagy
  • insulin
  • lifespan
  • metabolism
  • polyamine


Serine Phosphorylation of IRS1 Correlates with Aβ-Unrelated Memory Deficits and Elevation in Aβ Level Prior to the Onset of Memory Decline in AD.


MeSH Terms

  • Aging
  • Alzheimer Disease
  • Amyloid beta-Peptides
  • Amyloid beta-Protein Precursor
  • Animals
  • Brain
  • Diabetes Mellitus, Type 2
  • Humans
  • Insulin
  • Insulin Receptor Substrate Proteins
  • Male
  • Memory
  • Memory Disorders
  • Mice, Inbred C57BL
  • Mice, Transgenic
  • Phosphorylation
  • Serine
  • Signal Transduction

Keywords

  • AMPK
  • Alzheimer’s disease
  • Aβ
  • IRS1
  • aging
  • diabetes
  • energy depletion
  • hippocampus
  • memory decline
  • serine phosphorylation

IRS2[править]

Effects of Heshouwuyin on gene expression of the insulin/IGF signalling pathway in rat testis and spermatogenic cells.


Keywords

  • IGF1
  • IGFBP3
  • INSR
  • IRS1
  • IRS2
  • Male reproduction
  • senescence

ITGA3[править]

A transcriptomic analysis of serial-cultured, tonsil-derived mesenchymal stem cells reveals decreased integrin α3 protein as a potential biomarker of senescent cells.


Keywords

  • AKT
  • Culture-aged
  • ECM-receptor protein
  • Integrin α3
  • Senescence
  • Serial passaging
  • Tonsil-derived mesenchymal stem cells
  • Transcriptome

ITGA5[править]

Kaempferol alleviates the reduction of developmental competence during aging of porcine oocytes.


MeSH Terms

  • Animals
  • Blastocyst
  • Cellular Senescence
  • Embryo Culture Techniques
  • Embryo, Mammalian
  • Embryonic Development
  • Female
  • Integrins
  • Kaempferols
  • Mitochondria
  • Nanog Homeobox Protein
  • Octamer Transcription Factor-3
  • Oocytes
  • Oxidative Stress
  • RNA, Messenger
  • Reactive Oxygen Species
  • Swine

Keywords

  • embryonic development
  • kaempferol
  • oocyte aging
  • porcine

ITGAM[править]

Comparative Analysis of Gene Expression Patterns for Oral Epithelium-Related Functions with Aging.


MeSH Terms

  • Aging
  • Animals
  • Disease Models, Animal
  • Epithelial Cells
  • Gingiva
  • Macaca mulatta
  • Oligonucleotide Array Sequence Analysis
  • Transcriptome

IVD[править]

MicroRNAs in Intervertebral Disc Degeneration, Apoptosis, Inflammation, and Mechanobiology.


Keywords

  • ECM
  • MMP
  • annulus fibrosus
  • cartilaginous endplate
  • degenerative disc disease
  • miRNA
  • nucleus pulposus
  • senescence


A step-by-step protocol for isolation of murine nucleus pulposus cells.


Keywords

  • aging
  • gene expression
  • intervertebral disc degeneration
  • nucleus pulposus


Caspase-3 knockout inhibits intervertebral disc degeneration related to injury but accelerates degeneration related to aging.


MeSH Terms

  • Aging
  • Animals
  • Annulus Fibrosus
  • Apoptosis
  • Biomarkers
  • Carcinogenesis
  • Caspase 3
  • Cell Count
  • Extracellular Matrix
  • Intervertebral Disc
  • Intervertebral Disc Degeneration
  • Mice, Inbred C57BL
  • Mice, Knockout
  • Nucleus Pulposus
  • Up-Regulation


Finite element and deformation analyses predict pattern of bone failure in loaded zebrafish spines.


MeSH Terms

  • Aging
  • Animals
  • Back Pain
  • Disease Models, Animal
  • Finite Element Analysis
  • Humans
  • Intervertebral Disc
  • Movement
  • Weight-Bearing
  • Zebrafish

Keywords

  • deformation
  • finite element
  • geometric morphometrics
  • mechanics
  • spine
  • zebrafish


Improvement in determining the risk of damage to the human lumbar functional spinal unit considering age, height, weight and sex using a combination of FEM and RSM.


MeSH Terms

  • Adult
  • Age Factors
  • Aging
  • Analysis of Variance
  • Biomechanical Phenomena
  • Body Height
  • Body Mass Index
  • Body Weight
  • Cortical Bone
  • Female
  • Finite Element Analysis
  • Humans
  • Imaging, Three-Dimensional
  • Intervertebral Disc
  • Lumbar Vertebrae
  • Male
  • Models, Biological
  • Range of Motion, Articular
  • Risk Factors
  • Sex Characteristics

Keywords

  • Age
  • Biomechanics
  • Body mass index (BMI)
  • Finite element method (FEM)
  • Functional spinal unit (FSU)
  • Height
  • Response surface method (RSM)
  • Sex
  • Weight


In vivo contrast-enhanced microCT for the monitoring of mouse thoracic, lumbar, and coccygeal intervertebral discs.


Keywords

  • Contrast‐enhanced microCT
  • aging
  • intervertebral disc
  • mouse model

JAK1[править]

Irradiation-induced senescence of bone marrow mesenchymal stem cells aggravates osteogenic differentiation dysfunction via paracrine signaling.


MeSH Terms

  • Bone Resorption
  • Cell Cycle Checkpoints
  • Cell Differentiation
  • Cell Proliferation
  • Cellular Senescence
  • DNA Damage
  • Gene Expression Regulation, Developmental
  • Histones
  • Humans
  • Janus Kinase 1
  • Mesenchymal Stem Cells
  • Mitochondria
  • Osteogenesis
  • Paracrine Communication
  • Radiation
  • Reactive Oxygen Species
  • STAT3 Transcription Factor
  • Signal Transduction

Keywords

  • SASP
  • bone marrow mesenchymal stem cells
  • cellular senescence
  • irradiation
  • osteogenic differentiation


The Upregulation of Toll-Like Receptor 3 via Autocrine IFN-β Signaling Drives the Senescence of Human Umbilical Cord Blood-Derived Mesenchymal Stem Cells Through JAK1.


MeSH Terms

  • Autocrine Communication
  • Cellular Senescence
  • Fetal Blood
  • Humans
  • Interleukin-6
  • Janus Kinase 1
  • Mesenchymal Stem Cells
  • Toll-Like Receptor 3
  • Up-Regulation

Keywords

  • Janus kinase 1 (JAK1)
  • Toll-like receptor 3 (TLR3)
  • interferon-β (IFN-β)
  • mesenchymal stromal cell (MSC)
  • senescence

JAK2[править]

Senescence in Monocytes Facilitates Dengue Virus Infection by Increasing Infectivity.


Keywords

  • DC-SIGN
  • IL-10
  • dengue virus
  • monocytes
  • senescence


Quercetin Directly Targets JAK2 and PKCδ and Prevents UV-Induced Photoaging in Human Skin.


MeSH Terms

  • Antioxidants
  • Cell Line
  • Cells, Cultured
  • Cyclooxygenase 2
  • Humans
  • Janus Kinase 2
  • MAP Kinase Signaling System
  • Matrix Metalloproteinase 1
  • NF-kappa B
  • Protein Kinase C-delta
  • Quercetin
  • STAT3 Transcription Factor
  • Skin
  • Skin Aging
  • Transcription Factor AP-1
  • Ultraviolet Rays

Keywords

  • JAK2
  • PKC-delta
  • quercetin
  • skin aging


[Red blood cell lifespan detected by endogenous carbon monoxide breath test in patients with polycythemia vera].


MeSH Terms

  • Adult
  • Aged
  • Aged, 80 and over
  • Breath Tests
  • Carbon Monoxide
  • Case-Control Studies
  • Erythrocyte Count
  • Erythrocytes
  • Female
  • Humans
  • Janus Kinase 2
  • Longevity
  • Male
  • Middle Aged
  • Polycythemia Vera

Keywords

  • Carbon monoxide breath test
  • Polycythemia vera
  • Red blood cell lifespan


Roles of JAK2 in Aging, Inflammation, Hematopoiesis and Malignant Transformation.


MeSH Terms

  • Aging
  • Animals
  • Hematopoiesis
  • Humans
  • Inflammation
  • Janus Kinase 2
  • Mice
  • Myeloproliferative Disorders
  • Neoplasms

Keywords

  • JAK2
  • Janus-kinase
  • aging
  • clonal hematopoiesis (CHIP), myeloproliferative neoplasia (MPN)

JUN[править]

Age-Onset Phosphorylation of a Minor Actin Variant Promotes Intestinal Barrier Dysfunction.


MeSH Terms

  • Actin Cytoskeleton
  • Actins
  • Aging
  • Animals
  • Binding Sites
  • Caenorhabditis elegans
  • Caenorhabditis elegans Proteins
  • Intercellular Junctions
  • Intestinal Mucosa
  • JNK Mitogen-Activated Protein Kinases
  • Phosphorylation
  • Protein Phosphatase 1
  • Transcription Factors
  • Troponin

Keywords

  • HSF-1
  • actin
  • aging
  • barrier
  • intestine
  • junctions
  • kinase
  • pathogenesis
  • phosphorylation
  • stress

JUNB[править]

Promotion of cellular senescence by THG-1/TSC22D4 knockout through activation of JUNB.


MeSH Terms

  • Cell Line, Tumor
  • Cell Proliferation
  • Cellular Senescence
  • Cyclin-Dependent Kinase Inhibitor p21
  • Gene Expression Regulation, Neoplastic
  • Gene Knockout Techniques
  • HEK293 Cells
  • Humans
  • Transcription Factors
  • Transcription, Genetic
  • Up-Regulation

Keywords

  • Cellular senescence
  • JUNB
  • P21(CDKN1A)
  • THG-1(TSC22D4)

KAT6B[править]

Aging-associated decrease in the histone acetyltransferase KAT6B is linked to altered hematopoietic stem cell differentiation.


MeSH Terms

  • Aging
  • Animals
  • Cell Differentiation
  • Epigenesis, Genetic
  • Erythroid Cells
  • Gene Expression Profiling
  • Gene Expression Regulation, Enzymologic
  • Gene Knockout Techniques
  • Histone Acetyltransferases
  • Male
  • Mice
  • Mice, Transgenic
  • Myeloid Progenitor Cells
  • Transcriptome

KCNK2[править]

Brain age prediction using deep learning uncovers associated sequence variants.


MeSH Terms

  • Adolescent
  • Adult
  • Aged
  • Aged, 80 and over
  • Aging
  • Brain
  • Databases, Factual
  • Deep Learning
  • Genome-Wide Association Study
  • Humans
  • Iceland
  • Magnetic Resonance Imaging
  • Middle Aged
  • Neural Networks, Computer
  • Neuropsychological Tests
  • Polymorphism, Single Nucleotide
  • United Kingdom
  • Young Adult

KCNQ4[править]

Guanylyl Cyclase A/cGMP Signaling Slows Hidden, Age- and Acoustic Trauma-Induced Hearing Loss.


Keywords

  • KCNQ4
  • PARP-1
  • aging
  • cGMP
  • guanylyl cyclase A
  • hidden hearing loss
  • inner ear
  • otoprotection

KCTD12[править]

The association between poverty and gene expression within peripheral blood mononuclear cells in a diverse Baltimore City cohort.


MeSH Terms

  • Adult
  • Demography
  • Female
  • Gene Expression Profiling
  • Humans
  • Longevity
  • Male
  • Metabolic Networks and Pathways
  • Middle Aged
  • Monocytes
  • Poverty
  • Transcriptome
  • Urban Population

KDM2A[править]

SIRT6 mono-ADP ribosylates KDM2A to locally increase H3K36me2 at DNA damage sites to inhibit transcription and promote repair.


Keywords

  • DNA repair
  • SIRT6
  • genome stability
  • longevity
  • transcription

KDM2B[править]

Identification of Structural Elements of the Lysine Specific Demethylase 2B CxxC Domain Associated with Replicative Senescence Bypass in Primary Mouse Cells.


Keywords

  • Lysine demethylase
  • Non-methylated CpG
  • Oncogene
  • Polycomb repressive complex
  • Replicative senescence
  • Zn-finger

KDM3A[править]

KDM3A and KDM4C Regulate Mesenchymal Stromal Cell Senescence and Bone Aging via Condensin-mediated Heterochromatin Reorganization.


Keywords

  • Cell Biology
  • DNA damage
  • Molecular Mechanism of Gene Regulation
  • Stem Cells Research
  • bone aging
  • condensin
  • epigenetic regulation
  • histone demethylase
  • mesenchymal stromal cells

KEAP1[править]

NRF2 pathway activation by KEAP1 inhibition attenuates the manifestation of aging phenotypes in salivary glands.


Keywords

  • Aging
  • KEAP1
  • Mouse
  • NRF2
  • Salivary glands


Adaptation of the master antioxidant response connects metabolism, lifespan and feather development pathways in birds.


MeSH Terms

  • Adaptation, Physiological
  • Animals
  • Antioxidants
  • Basal Metabolism
  • Biological Evolution
  • Birds
  • Cell Nucleus
  • Feathers
  • Fibroblasts
  • Genomics
  • Glutathione Transferase
  • HEK293 Cells
  • Humans
  • Kelch-Like ECH-Associated Protein 1
  • Longevity
  • NF-E2-Related Factor 2
  • Oxidative Stress
  • Phylogeny
  • Proteasome Endopeptidase Complex
  • Protein Binding
  • Protein Transport
  • Ubiquitination
  • Up-Regulation

KIN[править]

The noncanonical small heat shock protein HSP-17 from [i]Caenorhabditis elegans[/i] is a selective protein aggregase.


MeSH Terms

  • Animals
  • Caenorhabditis elegans
  • Caenorhabditis elegans Proteins
  • Casein Kinase I
  • Heat-Shock Proteins, Small
  • Longevity
  • Malate Dehydrogenase
  • Peptides
  • Protein Aggregates
  • Protein Folding
  • RNA Interference
  • RNA, Small Interfering
  • Recombinant Proteins

Keywords

  • Caenorhabditis elegans (C. elegans)
  • chaperone
  • protein aggregates
  • protein aggregation
  • protein folding
  • proteostasis
  • selective protein aggregase
  • small heat shock protein (sHsp)

KIT[править]

Prediction of ovarian aging using ovarian expression of BMP15, GDF9, and C-KIT.


Keywords

  • BMP15
  • C-KIT
  • GDF9
  • Ovarian aging
  • biomarkers

KLF2[править]

KLF2 induces the senescence of pancreatic cancer cells by cooperating with FOXO4 to upregulate p21.


MeSH Terms

  • Animals
  • Carcinogenesis
  • Cell Cycle Proteins
  • Cell Line
  • Cells, Cultured
  • Cellular Senescence
  • Cyclin-Dependent Kinase Inhibitor p21
  • Forkhead Transcription Factors
  • Kruppel-Like Transcription Factors
  • Male
  • Mice
  • Mice, Nude
  • Pancreatic Neoplasms
  • Protein Binding
  • Up-Regulation

Keywords

  • FOXO4
  • KLF2
  • Pancreatic cancer
  • Senescence

KLF4[править]

Extracellular Vesicles from Healthy Cells Improves Cell Function and Stemness in Premature Senescent Stem Cells by miR-302b and HIF-1α Activation.


Keywords

  • aging
  • extracellular vesicles
  • oxygen
  • physiological oxygen concentration
  • physioxia
  • redox
  • senescence


Soluble klotho regulates the function of salivary glands by activating KLF4 pathways.


MeSH Terms

  • Animals
  • Cells, Cultured
  • Down-Regulation
  • Gene Expression Regulation
  • Glucuronidase
  • HEK293 Cells
  • Humans
  • Kruppel-Like Transcription Factors
  • Membrane Proteins
  • Mice
  • Mice, Knockout
  • Nuclear Proteins
  • RNA Interference
  • RNA, Small Interfering
  • Salivary Glands

Keywords

  • KLF4
  • aging
  • salivary gland
  • soluble klotho

KLF6[править]

Krüppel-Like Factor 6 Is Required for Oxidative and Oncogene-Induced Cellular Senescence.


Keywords

  • DNA damage
  • KLF6
  • cell proliferation
  • cellular senescence
  • ras oncogene

KRAS[править]

Chemical Pathology of Homocysteine VIII. Effects of Tocotrienol, Geranylgeraniol, and Squalene on Thioretinaco Ozonide, Mitochondrial Permeability, and Oxidative Phosphorylation in Arteriosclerosis, Cancer, Neurodegeneration and Aging.


Keywords

  • adenosine triphosphate
  • aging
  • antioxidant
  • apoptosis
  • atherogenesis
  • cancer
  • carcinogenesis
  • cholesterol
  • free radical
  • geraniol
  • geranylgeraniol
  • homocysteine
  • menoquinone
  • mitochondrial dysfunction
  • mitochondrial membrane potential
  • mitochondrial permeability transition pore
  • mitophagy
  • neuro-degeneration
  • oxidative phosphorylation
  • oxidative stress
  • squalene
  • statin
  • stellate cells
  • testosterone
  • thioretinaco ozonide
  • thioretinamide
  • tocopherol
  • tocotrienol
  • ubiquinone


Senescence-Induced Vascular Remodeling Creates Therapeutic Vulnerabilities in Pancreas Cancer.


MeSH Terms

  • Aging
  • Animals
  • CD8-Positive T-Lymphocytes
  • Carcinoma, Pancreatic Ductal
  • Cell Line, Tumor
  • Cell Proliferation
  • Cyclin-Dependent Kinase 4
  • Cyclin-Dependent Kinase 6
  • Gene Expression Regulation, Neoplastic
  • Genes, ras
  • Humans
  • Immunotherapy
  • MAP Kinase Signaling System
  • Mice
  • Pancreatic Neoplasms
  • Retinoblastoma Protein
  • Signal Transduction
  • Tumor Microenvironment
  • Vascular Remodeling

Keywords

  • T cells
  • chemotherapy resistance
  • endothelial cell activation
  • immunotherapy
  • pancreatic cancer
  • senescence
  • senescence-associated secretory phenotype
  • targeted therapy
  • tumor microenvironment
  • vascular biology

L1CAM[править]

Glioma malignancy is linked to interdependent and inverse AMOG and L1 adhesion molecule expression.


MeSH Terms

  • Adenosine Triphosphatases
  • Apoptosis
  • Biomarkers
  • Brain Neoplasms
  • Cation Transport Proteins
  • Cell Adhesion
  • Cell Adhesion Molecules, Neuronal
  • Cell Line, Tumor
  • Cellular Senescence
  • Gene Expression Profiling
  • Gene Expression Regulation, Neoplastic
  • Glioblastoma
  • Humans
  • Immunohistochemistry
  • Neural Cell Adhesion Molecule L1
  • RNA, Small Interfering
  • Signal Transduction

Keywords

  • AMOG
  • Apoptosis
  • Glioma
  • Human
  • L1CAM
  • Senescence
  • Therapy

LAG3[править]

T Cell Transcriptional Profiling and Immunophenotyping Uncover LAG3 as a Potential Significant Target of Immune Modulation in Multiple Myeloma.


Keywords

  • Autologous stem cell transplant
  • Exhaustion
  • LAG3
  • Multiple myeloma
  • Senescence

LAMP1[править]

Differential accumulation of storage bodies with aging defines discrete subsets of microglia in the healthy brain.


Keywords

  • CLN3
  • TREM2
  • aging
  • autofluorescence
  • immunology
  • inflammation
  • lysosomal storage disorder
  • microglia
  • mouse
  • neuroscience
  • rhesus macaque

LBP[править]

Lipopolysaccharide binding protein is associated with CVD risk in older adults.


Keywords

  • Aging
  • Cardiovascular disease risk
  • Intestinal permeability
  • Lipopolysaccharide binding protein


Aging-related liver degeneration is associated with increased bacterial endotoxin and lipopolysaccharide binding protein levels.


MeSH Terms

  • Acute-Phase Proteins
  • Aging
  • Animals
  • Apoptosis
  • Biomarkers
  • Carrier Proteins
  • Endotoxins
  • Female
  • Gene Expression Regulation
  • Glucose
  • Inflammation
  • Insulin Receptor Substrate Proteins
  • Liver
  • Liver Cirrhosis
  • Malate Dehydrogenase
  • Male
  • Membrane Glycoproteins
  • Mice
  • Mice, Inbred C57BL
  • Mice, Knockout
  • RNA, Messenger
  • Receptor, Insulin
  • Toll-Like Receptor 4

Keywords

  • Tlr-4 signaling
  • aging
  • bacterial endotoxin
  • lipopolysaccharide binding protein
  • liver degeneration


Biomarkers of leaky gut are related to inflammation and reduced physical function in older adults with cardiometabolic disease and mobility limitations.


MeSH Terms

  • Aged
  • Aging
  • Biomarkers
  • Exercise Therapy
  • Female
  • Follow-Up Studies
  • Humans
  • Inflammation
  • Male
  • Metabolic Syndrome
  • Middle Aged
  • Mobility Limitation
  • Motor Activity
  • Obesity
  • Retrospective Studies
  • Weight Loss

Keywords

  • Ageing
  • Lipopolysaccharide-binding protein
  • Microbial translocation
  • Physical function


Needle-shaped amyloid deposition in rat mammary gland: evidence of a novel amyloid fibril protein.


MeSH Terms

  • Aging
  • Amyloidogenic Proteins
  • Amyloidosis
  • Animals
  • Antigens, Surface
  • Female
  • Mammary Glands, Animal
  • Milk Proteins
  • Plaque, Amyloid
  • Rats
  • Rats, Sprague-Dawley

Keywords

  • Amyloidosis
  • lipopolysaccharide binding protein
  • mammary gland
  • pathology
  • rat


Effects of Lycium barbarum Polysaccharides on Health and Aging of [i]C. elegans[/i] Depend on [i]daf-12/daf-16[/i].


MeSH Terms

  • Aging
  • Animals
  • Caenorhabditis elegans
  • Caenorhabditis elegans Proteins
  • Drugs, Chinese Herbal
  • Receptors, Cytoplasmic and Nuclear

LBR[править]

Lamin B receptor: role on chromatin structure, cellular senescence and possibly aging.


Keywords

  • Aging
  • cancer
  • cellular senescence
  • chromatine structure
  • nuclear envelop


The impact of age beyond ploidy: outcome data from 8175 euploid single embryo transfers.


Keywords

  • Aneuploidy
  • Pregestational genetic testing
  • Reproductive aging
  • Single embryo transfer


The role of lamin B receptor in the regulation of senescence-associated secretory phenotype (SASP).


Keywords

  • Gene expression
  • LBR
  • SAHF
  • SASP
  • Senescence


Lamin B receptor plays a key role in cellular senescence induced by inhibition of the proteasome.


Keywords

  • LBR
  • autophagy
  • proteasome
  • protein accumulation
  • senescence
  • unbalanced growth

LEP[править]

Age- and Sex-Specific Changes in Lower-Limb Muscle Power Throughout the Lifespan.


Keywords

  • Aging
  • Body mass index
  • Dynapenia
  • Leg extension power
  • Sarcopenia
  • Skeletal muscle


The Copenhagen Sarcopenia Study: lean mass, strength, power, and physical function in a Danish cohort aged 20-93 years.


MeSH Terms

  • Adult
  • Aged
  • Aged, 80 and over
  • Body Composition
  • Cohort Studies
  • Cross-Sectional Studies
  • Denmark
  • Female
  • Hand Strength
  • Humans
  • Leg
  • Longevity
  • Middle Aged
  • Prospective Studies
  • Sarcopenia
  • Young Adult

Keywords

  • Body composition
  • DXA
  • Handgrip strength
  • Lean mass
  • Leg power
  • Sarcopenia

LGR6[править]

Effect of defensins-containing eye cream on periocular rhytids and skin quality.


Keywords

  • aging
  • defensins
  • periocular
  • rhytids
  • skin

LHCGR[править]

Comparative Study of the Steroidogenic Effects of Human Chorionic Gonadotropin and Thieno[2,3-D]pyrimidine-Based Allosteric Agonist of Luteinizing Hormone Receptor in Young Adult, Aging and Diabetic Male Rats.


Keywords

  • aging rats
  • diabetes mellitus
  • human chorionic gonadotropin
  • low-molecular-weight agonist
  • luteinizing hormone receptor
  • spermatogenesis
  • steroidogenesis
  • testes

LMNA[править]

Metformin alters peripheral blood mononuclear cells (PBMC) senescence biomarkers gene expression in type 2 diabetic patients.


Keywords

  • Inflammation and cellular senescence
  • Insulin resistance
  • LMNA/C transcript variants
  • Mononuclear cells
  • Type 2 diabetes mellitus


Protein structural and mechanistic basis of progeroid laminopathies.


Keywords

  • 3D structure
  • aging disorders
  • contact sites
  • lamin
  • nuclear structure


Progerin Expression Induces Inflammation, Oxidative Stress and Senescence in Human Coronary Endothelial Cells.


Keywords

  • Hutchinson–Gilford progeria syndrome
  • LMNA
  • aging
  • atherosclerosis
  • endothelial dysfunction
  • inflammation
  • lamin A
  • prenylation
  • progerin


The JAK1/2 inhibitor ruxolitinib delays premature aging phenotypes.


Keywords

  • JAK/STAT pathway
  • cellular senescence
  • progeria
  • ruxolitinib


Pharmacotherapy to gene editing: potential therapeutic approaches for Hutchinson-Gilford progeria syndrome.


Keywords

  • Aging
  • Extracellular vesicles
  • Hutchinson–Gilford progeria syndrome
  • Progerin
  • Stem cells
  • Therapeutics


Long term breeding of the Lmna G609G progeric mouse: Characterization of homozygous and heterozygous models.


Keywords

  • Aging
  • Animal model breeding
  • Bone strength
  • Hutchinson-Gilford Progeria Syndrome (HGPS)
  • Kyphosis
  • Quality of life

LMNB1[править]

SIRT1 - a new mammalian substrate of nuclear autophagy.


Keywords

  • Aging
  • SIRT1
  • nuclear autophagy
  • senescence
  • sirtuin


Cellular senescence as a response to multiwalled carbon nanotube (MWCNT) exposure in human mesothelial cells.


Keywords

  • alpha tubulin
  • cellular senescence
  • mesothelial cells
  • microarray analysis
  • multiwalled carbon nanotubes
  • γH2A.X


Inflammatory Drivers of Cardiovascular Disease: Molecular Characterization of Senescent Coronary Vascular Smooth Muscle Cells.


Keywords

  • aging
  • cardiovascular
  • inflammation
  • senescence
  • smooth muscle cell

LOX[править]

12-LOX catalyzes the oxidation of 2-arachidonoyl-lysolipids in platelets generating eicosanoid-lysolipids that are attenuated by iPLA γ knockout.


Keywords

  • 2-arachidonoyl-lysophospholipids
  • aging
  • calcium
  • eicosanoid
  • iPLA2γ
  • lysophospholipid
  • myocardium
  • platelet
  • platelet-type 12-lipoxygenase (12-LOX)
  • polyunsaturated fatty acids (PUFAs)

LOXL1[править]

A blackberry-dill extract combination synergistically increases skin elasticity.


Keywords

  • blackberry-dill
  • elasticity
  • skin aging
  • skin physiology/structure
  • skin repair

LOXL2[править]

Lysyl Oxidase-Like 2 Protects against Progressive and Aging Related Knee Joint Osteoarthritis in Mice.


MeSH Terms

  • Adenoviridae
  • Aging
  • Amino Acid Oxidoreductases
  • Animals
  • Arthritis, Experimental
  • Cartilage, Articular
  • Disease Models, Animal
  • Disease Progression
  • Gene Expression
  • Gene Transfer Techniques
  • Genetic Vectors
  • Interleukin-1beta
  • Mice
  • Mice, Transgenic
  • NF-kappa B
  • Osteoarthritis, Knee
  • Transduction, Genetic

Keywords

  • Lysyl oxidase like-2
  • adenovirus delivery
  • anabolic response
  • articular cartilage
  • knee joint
  • osteoarthritis
  • regeneration

LPA[править]

Ginseng gintonin, aging societies, and geriatric brain diseases.


Keywords

  • Brain aging
  • Gintonin
  • Neurodegenerative diseases
  • Panax ginseng
  • Rejuvenation


Late-life related subtypes of depression - a data-driven approach on cognitive domains and physical frailty.


Keywords

  • cognitive aging
  • depression
  • frailty


Does sedentary time increase in older adults in the days following participation in intense exercise?


MeSH Terms

  • Accelerometry
  • Aged
  • Exercise
  • Exercise Test
  • Humans
  • Sedentary Behavior
  • Sleep

Keywords

  • Aging
  • Compensation
  • High intensity
  • Movement behaviours


Association of Long-term Exposure to Elevated Lipoprotein(a) Levels With Parental Life Span, Chronic Disease-Free Survival, and Mortality Risk: A Mendelian Randomization Analysis.


MeSH Terms

  • Aged
  • Case-Control Studies
  • Cross-Sectional Studies
  • Female
  • Humans
  • Lipoprotein(a)
  • Longevity
  • Male
  • Mendelian Randomization Analysis
  • Middle Aged
  • Parents
  • Phenotype
  • Prospective Studies
  • Risk Factors


Elevated Autotaxin and LPA Levels During Chronic Viral Hepatitis and Hepatocellular Carcinoma Associate with Systemic Immune Activation.


Keywords

  • Aging
  • Autotaxin
  • Hepatitis
  • Hepatocellular Carcinoma
  • Immune Activation
  • Immunity
  • Inflammation
  • Liver
  • Lysophosphatidic Acid


Lysophosphatidic acid receptor LPA prevents oxidative stress and cellular senescence in Hutchinson-Gilford progeria syndrome.


Keywords

  • 1-Oleoyl-2-O-methyl-rac-glycerophosphothionate
  • Hutchinson-Gilford progeria syndrome
  • LPA3
  • cell senescence
  • lysophosphatidic acid
  • reactive oxygen species


Associations of Sedentary and Physically-Active Behaviors With Cognitive-Function Decline in Community-Dwelling Older Adults: Compositional Data Analysis From the NEIGE Study.


Keywords

  • accelerometry
  • aging
  • exercise
  • neurocognitive disorders
  • sedentary lifestyle


Validation and comparison of two automated methods for quantifying brain white matter hyperintensities of presumed vascular origin.


Keywords

  • White matter hyperintensity
  • brain aging
  • cerebral small vessel disease
  • lesion segmentation
  • methodology
  • validation


The Sedentary Time and Physical Activity Levels on Physical Fitness in the Elderly: A Comparative Cross Sectional Study.


MeSH Terms

  • Accelerometry
  • Aged
  • Aged, 80 and over
  • Aging
  • Body Mass Index
  • Cross-Sectional Studies
  • Exercise
  • Female
  • Humans
  • Male
  • Physical Fitness
  • Sedentary Behavior

Keywords

  • accelerometry
  • ageing
  • health
  • physical fitness
  • sedentary behaviour


Light-Intensity Physical Activity in a Large Prospective Cohort of Older US Adults: A 21-Year Follow-Up of Mortality.


MeSH Terms

  • Aged
  • Cardiovascular Diseases
  • Cohort Studies
  • Exercise
  • Female
  • Follow-Up Studies
  • Humans
  • Leisure Activities
  • Male
  • Middle Aged
  • Mortality
  • Neoplasms
  • Proportional Hazards Models
  • Prospective Studies
  • Respiratory Tract Diseases
  • Risk Factors
  • Surveys and Questionnaires
  • United States

Keywords

  • Aging
  • Cancer prevention study
  • Leisure time physical activity
  • Light-intensity physical activity

LPL[править]

Survival analyses in Holstein cows considering direct disease diagnoses and specific SNP marker effects.


Keywords

  • SNP effect
  • Weibull hazards model
  • genetic parameter
  • health disorder
  • longevity


Influence of common health disorders on the length of productive life and stayability in German Holstein cows.


MeSH Terms

  • Animals
  • Breeding
  • Cattle
  • Cattle Diseases
  • Dairying
  • Farmers
  • Female
  • Lactation
  • Longevity
  • Phenotype

Keywords

  • genetic parameter
  • health disorder
  • longevity
  • subjective culling reason

LPO[править]

[Features of the changes in lipid peroxidation and activity of Na+/K+-ATPase in the brain of the aged rats in the conditions of two-vessel cerebral ischemia/reperfusion.]


MeSH Terms

  • Aging
  • Animals
  • Brain Ischemia
  • Disease Models, Animal
  • Lipid Peroxidation
  • Rats
  • Reperfusion Injury
  • Sodium-Potassium-Exchanging ATPase

Keywords

  • Na+/K+-ATPase
  • aging
  • brain
  • lipid peroxidation
  • oxidative stress
  • stroke

LRP1[править]

Drug Targeting of Plasminogen Activator Inhibitor-1 Inhibits Metabolic Dysfunction and Atherosclerosis in a Murine Model of Metabolic Syndrome.


MeSH Terms

  • Animals
  • Atherosclerosis
  • Cellular Senescence
  • Diet, Western
  • Disease Models, Animal
  • Indoleacetic Acids
  • Macrophages
  • Metabolic Syndrome
  • Mice
  • Mice, Knockout
  • Obesity
  • Plaque, Atherosclerotic
  • Plasminogen Activator Inhibitor 1
  • Receptors, LDL

Keywords

  • atherosclerosis
  • cellular senescence
  • fibrinolysis
  • metabolic syndrome
  • muscle, smooth
  • obesity
  • plasminogen activator inhibitor-1

LRP4[править]

Multiple MuSK signaling pathways and the aging neuromuscular junction.


Keywords

  • Aging
  • BMP signaling
  • MuSK
  • Neuromuscular junction
  • Synaptic maintenance

LRP6[править]

Low-density lipoprotein receptor-related protein 6-mediated signaling pathways and associated cardiovascular diseases: diagnostic and therapeutic opportunities.


MeSH Terms

  • Aging
  • Animals
  • Cardiovascular Diseases
  • Humans
  • Low Density Lipoprotein Receptor-Related Protein-6
  • Muscle, Smooth, Vascular
  • Myocytes, Smooth Muscle
  • Obesity
  • Signal Transduction
  • Structure-Activity Relationship
  • Vascular Calcification
  • Wnt Signaling Pathway

LRRK2[править]

Accelerated telomere shortening independent of LRRK2 variants in Chinese patients with Parkinson's disease.


Keywords

  • LRRK2 variants
  • Parkinson’s disease
  • aging
  • telomere length


The effect of LRRK2 loss-of-function variants in humans.


MeSH Terms

  • Adult
  • Aged
  • Aged, 80 and over
  • Biological Specimen Banks
  • Cell Line
  • Embryonic Stem Cells
  • Female
  • Gain of Function Mutation
  • Heterozygote
  • Humans
  • Leucine-Rich Repeat Serine-Threonine Protein Kinase-2
  • Longevity
  • Loss of Function Mutation
  • Lymphocytes
  • Male
  • Middle Aged
  • Myocytes, Cardiac
  • Parkinson Disease
  • Phenotype


Parkinson's disease-related Leucine-rich repeat kinase 2 modulates nuclear morphology and genomic stability in striatal projection neurons during aging.


Keywords

  • And aging
  • Dendritic hypotrophy
  • Excitability
  • G2019S
  • GABAA
  • LRRK2
  • Nuclear DNA damage
  • Nuclear hypertrophy
  • Nuclear invagination
  • Parkinson’s disease
  • R1441C
  • Striatal spiny projection neuron


Autophagy and LRRK2 in the Aging Brain.


Keywords

  • LAMP2A
  • LC3
  • LRRK2
  • Parkinson’s disease
  • aging
  • autophagy
  • lysosomes
  • α-synuclein

LSS[править]

Surgical results in older patients with lumbar spinal stenosis according to gait speed in relation to the diagnosis for sarcopenia.


Keywords

  • aging
  • elderly person
  • gait speed
  • lumbar spinal stenosis
  • lumbar spine
  • muscle strength
  • sarcopenia
  • skeletal muscle mass
  • surgical result


Streamlining an existing hip fracture patient pathway in an acute tertiary adult Irish hospital to improve patient experience and outcomes.


MeSH Terms

  • Aged
  • Aged, 80 and over
  • Delivery of Health Care, Integrated
  • Geriatrics
  • Hip Fractures
  • Hospitals, Teaching
  • Humans
  • Ireland
  • Length of Stay
  • Nerve Block
  • Orthopedics
  • Pain Management
  • Total Quality Management
  • Treatment Outcome

Keywords

  • Lean Six Sigma
  • healthcare outcomes
  • hip fracture care
  • integrated care pathways
  • interdisciplinary working
  • process improvement

LTA[править]

Lipoteichoic acid from the cell wall of a heat killed Lactobacillus paracasei D3-5 ameliorates aging-related leaky gut, inflammation and improves physical and cognitive functions: from C. elegans to mice.


Keywords

  • Aging
  • Cell wall
  • Cognition
  • Goblet cell
  • Inflammation
  • Leaky gut
  • Lipoteichoic acid
  • Metabolism
  • Mucin
  • Physical function
  • Probiotics


The change of pain classes over time: a latent transition analysis.


MeSH Terms

  • Aged
  • Aging
  • Humans
  • Life Style
  • Longitudinal Studies
  • Middle Aged
  • Pain
  • Quality of Life

LY6D[править]

LY6D-induced macropinocytosis as a survival mechanism of senescent cells.


Keywords

  • LY6D
  • Ras protein
  • cellular senescence
  • endocytosis
  • lipid raft
  • macropinocytosis
  • vacuole

MAG[править]

Exploration of life satisfaction of Korean people with sensory impairments across the lifespan.


Keywords

  • Across the lifespan
  • Leisure domain
  • Life satisfaction
  • Sensory impairment
  • Social domain

MALT1[править]

MALT-1 mediates IL-17 neural signaling to regulate C. elegans behavior, immunity and longevity.


MeSH Terms

  • Animals
  • Behavior, Animal
  • Caenorhabditis elegans
  • Caenorhabditis elegans Proteins
  • Gene Expression Regulation
  • Green Fluorescent Proteins
  • Immunity
  • Interleukin-17
  • Interneurons
  • Longevity
  • Models, Biological
  • Mucosa-Associated Lymphoid Tissue Lymphoma Translocation 1 Protein
  • Neurons
  • Oxygen
  • Signal Transduction
  • Subcellular Fractions
  • Transgenes


MALT1-Deficient Mice Develop Atopic-Like Dermatitis Upon Aging.


MeSH Terms

  • Age Factors
  • Animals
  • CTLA-4 Antigen
  • Cytokines
  • Dermatitis, Atopic
  • Disease Models, Animal
  • Disease Susceptibility
  • Gene Expression
  • Genetic Predisposition to Disease
  • Immunoglobulin E
  • Lymphocyte Activation
  • Mice
  • Mice, Knockout
  • Mucosa-Associated Lymphoid Tissue Lymphoma Translocation 1 Protein
  • Skin
  • T-Lymphocyte Subsets

Keywords

  • MALT1
  • Th2
  • Tregs
  • aging
  • atopic dermatitis
  • lymphocytes
  • skin inflammation

MAP2[править]

Protective effects of ischemic preconditioning against neuronal apoptosis and dendritic injury in the hippocampus are age-dependent.


Keywords

  • aging
  • diffusion tensor imaging
  • immunohistochemistry
  • ischemic preconditioning

MAP4K3[править]

MAP4K3/GLK in autoimmune disease, cancer and aging.


MeSH Terms

  • Aging
  • Autoimmune Diseases
  • Humans
  • Neoplasms
  • Protein-Serine-Threonine Kinases

Keywords

  • Aging
  • Autoimmune disease
  • Autophagy
  • Cancer metastasis
  • HPK1
  • IL-17A
  • IQGAP1
  • MAP4K3 (GLK)
  • PKCθ
  • Verteporfin

MAPK1[править]

Purified Vitexin Compound 1 Inhibits UVA-Induced Cellular Senescence in Human Dermal Fibroblasts by Binding Mitogen-Activated Protein Kinase 1.


Keywords

  • MAPK1
  • VB1
  • purified vitexin compound 1
  • senescence
  • skin photoaging

MAPKAPK2[править]

Quantitative In Vivo Proteomics of Metformin Response in Liver Reveals AMPK-Dependent and -Independent Signaling Networks.


MeSH Terms

  • AMP-Activated Protein Kinases
  • Animals
  • Calcium
  • Cell Line
  • Endocytosis
  • HEK293 Cells
  • Homeostasis
  • Humans
  • Intracellular Signaling Peptides and Proteins
  • Liver
  • Metformin
  • Mice
  • Phosphorylation
  • Protein Kinase C
  • Protein-Serine-Threonine Kinases
  • Proteomics
  • Signal Transduction

Keywords

  • AMPK3
  • LKB1
  • PKD1
  • STIM1
  • aging
  • calcium
  • diabetes
  • kinases
  • liver
  • metformin

MAPT[править]

Association of relative brain age with tobacco smoking, alcohol consumption, and genetic variants.


MeSH Terms

  • Aged
  • Aged, 80 and over
  • Aging
  • Alcohol Drinking
  • Biological Specimen Banks
  • Brain
  • Cognition
  • Female
  • Humans
  • Magnetic Resonance Imaging
  • Male
  • Middle Aged
  • Neuroimaging
  • Polymorphism, Single Nucleotide
  • Smoking
  • United Kingdom
  • tau Proteins


A blood-based nutritional risk index explains cognitive enhancement and decline in the multidomain Alzheimer prevention trial.


Keywords

  • Aging
  • Biomarkers of diet quality
  • Cognitive decline
  • DHA
  • EPA
  • Elderly
  • Homocysteine
  • Metabolomics
  • Nutrient biomarkers
  • Omega-3 fatty acids
  • Vitamin D


Longitudinal associations of physical activity levels with morphological and functional changes related with aging: The MAPT study.


MeSH Terms

  • Aged
  • Aged, 80 and over
  • Aging
  • Alzheimer Disease
  • Body Composition
  • Brain
  • Cognition
  • Exercise
  • Female
  • Humans
  • Longitudinal Studies
  • Male

Keywords

  • Aging
  • Biomarkers
  • Phenotype
  • Physical activity


Ageing and amyloidosis underlie the molecular and pathological alterations of tau in a mouse model of familial Alzheimer's disease.


MeSH Terms

  • Aging
  • Alzheimer Disease
  • Amyloid beta-Peptides
  • Amyloidosis
  • Animals
  • Disease Models, Animal
  • Mice
  • Mice, Transgenic
  • tau Proteins


Revisiting the intersection of amyloid, pathologically modified tau and iron in Alzheimer's disease from a ferroptosis perspective.


Keywords

  • Alzheimer’s disease
  • Ferroptosis
  • Iron
  • Reactive oxygen species
  • Senescence
  • Tau

MATN3[править]

Mice Lacking the Matrilin Family of Extracellular Matrix Proteins Develop Mild Skeletal Abnormalities and Are Susceptible to Age-Associated Osteoarthritis.


MeSH Terms

  • Aging
  • Animals
  • Cell Proliferation
  • Cells, Cultured
  • Chondrocytes
  • Disease Models, Animal
  • Female
  • Gene Knockout Techniques
  • Humans
  • Male
  • Matrilin Proteins
  • Mice
  • Mice, Knockout
  • Microscopy, Atomic Force
  • Muscle, Skeletal
  • Osteoarthritis

Keywords

  • articular cartilage
  • bone development
  • cartilage
  • matrilin
  • osteoarthritis

MB[править]

Probing menstrual bloodstain aging with fluorescence spectroscopy.


Keywords

  • Aging
  • Analytical methods
  • Blood
  • Fluorescence spectroscopy
  • Forensics


Effect of physical exercise and medication on enhancing cognitive function in older adults with vascular risk.


MeSH Terms

  • Aged
  • Aged, 80 and over
  • Cognition
  • Cross-Sectional Studies
  • Exercise
  • Exercise Therapy
  • Female
  • Humans
  • Male
  • Middle Aged
  • Risk Factors
  • Vascular Diseases

Keywords

  • active aging
  • cognitive preservation
  • exercise habit
  • lifestyle advice
  • vascular care


A novel indenone derivative selectively induces senescence in MDA-MB-231 (breast adenocarcinoma) cells.


MeSH Terms

  • Antineoplastic Agents
  • Breast Neoplasms
  • Catalysis
  • Cell Line, Tumor
  • Cell Survival
  • Cellular Senescence
  • Cyclin-Dependent Kinase Inhibitor p21
  • Down-Regulation
  • Female
  • G1 Phase Cell Cycle Checkpoints
  • Humans
  • Palladium
  • Sulfonamides
  • Survivin
  • Tumor Suppressor Protein p53
  • Up-Regulation

Keywords

  • Cell cycle arrest
  • Novel indenone derivative
  • Senescence
  • Triple-negative breast cancer


Improved Autophagic Flux in Escapers from Doxorubicin-Induced Senescence/Polyploidy of Breast Cancer Cells.


Keywords

  • DNA damage
  • Rubicon
  • SQSTM1/p62
  • TFEB
  • autophagic index
  • autophagy
  • cancer
  • polyploidy
  • senescence
  • senescence escape


Lifespan regulation in α/β posterior neurons of the fly mushroom bodies by Rab27.


Keywords

  • Drosophila
  • Rab27
  • S6K
  • TOR
  • lifespan extension
  • mushroom body


Tailored Functionalized Magnetic Nanoparticles to Target Breast Cancer Cells Including Cancer Stem-Like Cells.


Keywords

  • apoptosis
  • cancer stem-like cells
  • doxorubicin
  • magnetic iron oxide nanoparticles
  • mitotic catastrophe
  • senescence


"Mitotic Slippage" and Extranuclear DNA in Cancer Chemoresistance: A Focus on Telomeres.


Keywords

  • ALT
  • SQSTM1/p62
  • amoeboid conversion
  • budding of mitotic progeny
  • cellular senescence
  • extranuclear DNA
  • genotoxic treatment
  • inverted meiosis
  • mtTP53 cancer
  • polyploidization


Diversity of the Senescence Phenotype of Cancer Cells Treated with Chemotherapeutic Agents.


MeSH Terms

  • Antineoplastic Agents
  • Cell Proliferation
  • Cellular Senescence
  • Cyclin-Dependent Kinase Inhibitor p21
  • Doxorubicin
  • Fluorouracil
  • Humans
  • Irinotecan
  • Methotrexate
  • Neoplasms
  • Oxaliplatin
  • Paclitaxel
  • Phenotype
  • Tumor Cells, Cultured

Keywords

  • DNA damage
  • SASP
  • cancer
  • chemotherapy
  • senescence
  • senescence markers


Downregulation of the inflammatory network in senescent fibroblasts and aging tissues of the long-lived and cancer-resistant subterranean wild rodent, Spalax.


Keywords

Spalax

  • DNA damage
  • DNA repair
  • cellular senescence
  • interleukin-1 alpha (IL1α)
  • nuclear factor κB (NF-κB)
  • senescence-associated secretory phenotype (SASP)


Quantification of the health-status of the Dutch Labrador retriever population.


MeSH Terms

  • Animals
  • Dog Diseases
  • Dogs
  • Female
  • Health Status
  • Insurance
  • Laboratories
  • Longevity
  • Male
  • Netherlands
  • Proportional Hazards Models
  • Risk Factors

Keywords

  • Canine health
  • Data analysis
  • Health parameters
  • Labrador retriever
  • Lifespan
  • Oncology


Conjugated Physiological Resveratrol Metabolites Induce Senescence in Breast Cancer Cells: Role of p53/p21 and p16/Rb Pathways, and ABC Transporters.


MeSH Terms

  • ATP-Binding Cassette Transporters
  • Breast Neoplasms
  • Cell Cycle Checkpoints
  • Cellular Senescence
  • Cyclin-Dependent Kinase Inhibitor p16
  • Cyclin-Dependent Kinase Inhibitor p21
  • Female
  • Glucuronides
  • Humans
  • MCF-7 Cells
  • Resveratrol
  • Retinoblastoma Protein
  • Signal Transduction
  • Stilbenes
  • Tumor Suppressor Protein p53

Keywords

  • ABC transporters
  • breast cancer
  • deconjugation
  • resveratrol metabolites
  • senescence

MBP[править]

Demyelination associated with chronic arsenic exposure in Wistar rats.


MeSH Terms

  • Aging
  • Amyloid beta-Protein Precursor
  • Animals
  • Arsenic Poisoning
  • Arsenites
  • Axons
  • Corpus Callosum
  • Demyelinating Diseases
  • Diffusion Tensor Imaging
  • Drinking Water
  • Immunohistochemistry
  • Male
  • Mitochondria
  • Myelin Basic Protein
  • Neurofilament Proteins
  • Prefrontal Cortex
  • Rats
  • Rats, Wistar
  • Sodium Compounds
  • White Matter

Keywords

  • Amyloid
  • Anisotropy
  • Arsenic
  • Axonal damage
  • DTI
  • Demyelination
  • Development
  • MRI
  • Microstructure
  • Mitochondria


Natural killer cells as participants in pathogenesis of rat experimental autoimmune encephalomyelitis (EAE): lessons from research on rats with distinct age and strain.


Keywords

  • EAE
  • NK cells
  • aging
  • dendritic cells
  • strain differences

MCC[править]

Multiple chronic conditions and risk of cognitive impairment and dementia among older Americans: findings from the Aging, Demographics, and Memory Study (ADAMS).


Keywords

  • Aging
  • and memory study
  • cognitive impairment with no dementia
  • dementia
  • demographics
  • multimorbidity
  • multiple chronic conditions


Behaviour consistency is a sensitive tool for distinguishing the effects of aging on physical activity.


Keywords

  • Aging
  • Behaviour consistency
  • Heart rate
  • Physical activity
  • Treadmill running


Burden on Caregivers of Adults with Multiple Chronic Conditions: Intersectionality of Age, Gender, Education level, Employment Status, and Impact on Social Life.


Keywords

  • aging
  • analyse d’intersectionnalité
  • caregiver burden
  • fardeau de l’aidant
  • gender
  • interférence sociale
  • intersectionality analysis
  • maladies chroniques multiples
  • multiple chronic conditions
  • sexe
  • social interference
  • vieillissement

MCM9[править]

MCM8- and MCM9 Deficiencies Cause Lifelong Increased Hematopoietic DNA Damage Driving p53-Dependent Myeloid Tumors.


MeSH Terms

  • Aging
  • Animals
  • Apoptosis
  • Bone Marrow
  • Cell Differentiation
  • Cell Proliferation
  • DNA Damage
  • Gene Expression Regulation, Leukemic
  • Hematologic Neoplasms
  • Mice
  • Mice, Knockout
  • Minichromosome Maintenance Proteins
  • Retinoblastoma Protein
  • Signal Transduction
  • Splenomegaly
  • Tumor Suppressor Protein p53

Keywords

  • DNA damage
  • DNA repair
  • MCM8
  • MCM9
  • cancer
  • hematopoiesis
  • homologous recombination
  • myelodysplastic syndrome

MCU[править]

A rare case of Epstein-Barr virus-positive mucocutaneous ulcer that developed into an intestinal obstruction: a case report.


MeSH Terms

  • Aged, 80 and over
  • Colon, Transverse
  • Epstein-Barr Virus Infections
  • Herpesvirus 4, Human
  • Humans
  • Intestinal Mucosa
  • Intestinal Obstruction
  • Male
  • Ulcer

Keywords

  • Aging
  • Epstein–Barr virus-positive mucocutaneous ulcer (EBV-MCU)
  • Immunosuppression
  • Intestinal obstruction
  • Surgical resection


Inhibition of Mitochondrial Calcium Overload by SIRT3 Prevents Obesity- or Age-Related Whitening of Brown Adipose Tissue.


MeSH Terms

  • Adipocytes, Brown
  • Adipose Tissue, Brown
  • Aging
  • Animals
  • Calcium
  • Capsaicin
  • Gene Expression Regulation
  • Mice
  • Mice, Knockout
  • Mitochondria
  • Obesity
  • Sirtuin 3

MDH1[править]

Oxidative Damage to the TCA Cycle Enzyme MDH1 Dysregulates Bioenergetic Enzymatic Activity in the Aged Murine Brain.


Keywords

  • DPM
  • MRM
  • TCA cycle
  • aging
  • brain

MDM2[править]

SENEBLOC, a long non-coding RNA suppresses senescence via p53-dependent and independent mechanisms.


MeSH Terms

  • Aging
  • Animals
  • Carcinogenesis
  • Cyclin-Dependent Kinase Inhibitor p21
  • Gene Expression Regulation, Neoplastic
  • HCT116 Cells
  • Heterografts
  • Histone Deacetylases
  • Humans
  • Mice
  • Neoplasms
  • Protein Binding
  • RNA, Long Noncoding
  • Signal Transduction
  • Tumor Suppressor Protein p53


Disruption of Robo2-Baiap2 integrated signaling drives cystic disease.


MeSH Terms

  • Animals
  • Cell Differentiation
  • Cell Proliferation
  • Cellular Senescence
  • Cilia
  • Disease Models, Animal
  • Epithelial Cells
  • Humans
  • Kidney
  • Kidney Diseases, Cystic
  • Mice
  • Mice, Knockout
  • Nerve Tissue Proteins
  • Protein Binding
  • Protein Domains
  • Receptors, Immunologic
  • Signal Transduction
  • Tumor Suppressor Protein p53

Keywords

  • Cellular senescence
  • Development
  • Genetic diseases
  • Nephrology
  • Signal transduction


Senescence-induced immunophenotype, gene expression and electrophysiology changes in human amniocytes.


MeSH Terms

  • Amniocentesis
  • Amnion
  • Biomarkers
  • Cell Proliferation
  • Cells, Cultured
  • Cellular Senescence
  • Electrophysiological Phenomena
  • Female
  • Gene Expression Regulation
  • Humans
  • Immunophenotyping
  • Phenotype

Keywords

  • amniocyte
  • automated patch-clamp
  • flow cytometry
  • mesenchymal stem cell
  • qRT-PCR
  • replicative senescence
  • senescence-associated secretory phenotype

MED25[править]

The [i]HAC1[/i] histone acetyltransferase promotes leaf senescence and regulates the expression of [i]ERF022[/i].


Keywords

  • ERF022
  • H3K9ac
  • HAC1
  • Mediator complex
  • histone acetylation
  • leaf senescence

MEFV[править]

The grandfather's fever.


MeSH Terms

  • Age of Onset
  • Aged, 80 and over
  • Familial Mediterranean Fever
  • Female
  • Humans
  • Male
  • Pedigree
  • Pyrin

Keywords

  • Autoinflammatory diseases
  • FMF
  • Genetics
  • Geriatrics
  • Periodic fever

MEOX2[править]

Reduced expression of microRNA-130a promotes endothelial cell senescence and age-dependent impairment of neovascularization.


Keywords

  • aging
  • angiogenesis
  • microRNA
  • neovascularization
  • senescence

MET[править]

Self-rated health in relation to fruit and vegetable consumption and physical activity among older cancer survivors.


Keywords

  • Cancer survivorship
  • Epidemiology
  • Fruit and vegetable
  • Gerontology
  • Physical activity


Leisure-time physical activity volume, intensity, and duration from mid- to late-life in U.S. subpopulations by race and sex. The Atherosclerosis Risk In Communities (ARIC) Study.


Keywords

  • exercise
  • healthy aging
  • physical activity
  • retirement
  • successful aging


Repressive H3K9me2 protects lifespan against the transgenerational burden of COMPASS activity in [i]C. elegans[/i].


MeSH Terms

  • Animals
  • Caenorhabditis elegans
  • Caenorhabditis elegans Proteins
  • Heterochromatin
  • Histone-Lysine N-Methyltransferase
  • Histones
  • Inheritance Patterns
  • Jumonji Domain-Containing Histone Demethylases
  • Longevity
  • Lysine
  • Methylation
  • Mutation

Keywords

  • C. elegans
  • COMPASS
  • aging
  • chromatin
  • chromosomes
  • epigenetics
  • gene expression
  • genetics
  • genomics
  • heterochromatin
  • transgenerational inheritance


Influence of Anthropometrics on Step-Rate Thresholds for Moderate and Vigorous Physical Activity in Older Adults: Scientific Modeling Study.


Keywords

  • aging
  • cadence
  • physical activity intensity
  • public health
  • walking

MFI[править]

The Influence of the Accelerated Aging Conditions on the Properties of Polyolefin Geogrids Used for Landfill Slope Reinforcement.


Keywords

  • HDPE
  • accelerated aging tests
  • decrease mechanical properties
  • degradation
  • geosynthetics
  • landfill
  • polyolefin


Changes in Physical Meat Traits, Protein Solubility, and the Microstructure of Different Beef Muscles during Post-Mortem Aging.


Keywords

  • aging
  • beef muscle
  • microstructure
  • myofibril fragmentation
  • protein solubility


Effect of a low-voltage electrical stimulation on yak meat tenderness during postmortem aging.


MeSH Terms

  • Animals
  • Cattle
  • Cold Temperature
  • Electric Stimulation
  • Food Handling
  • Food Quality
  • Food Storage
  • Hydrogen-Ion Concentration
  • Male
  • Meat
  • Muscle, Skeletal
  • Polysaccharides
  • Postmortem Changes
  • Time Factors

Keywords

  • Yak
  • electrical stimulation
  • postmortem aging
  • tenderness


Comparative effects of dry-aging and wet-aging on physicochemical properties and digestibility of Hanwoo beef.


Keywords

  • Beef Loin
  • Digestibility
  • Dry Aging
  • Shear Force
  • Wet Aging

MFN2[править]

Thioredoxin protects mitochondrial structure, function and biogenesis in myocardial ischemia-reperfusion via redox-dependent activation of AKT-CREB- PGC1α pathway in aged mice.


Keywords

  • aging
  • heart
  • ischemia-reperfusion
  • mitochondria
  • thioredoxin


MFN2 contributes to metabolic disorders and inflammation in the aging of rat chondrocytes and osteoarthritis.


Keywords

  • Aging
  • Inflammation
  • MFN2
  • Metabolic disorders
  • Osteoarthritis

MFSD2A[править]

Decreased Blood Level of MFSD2a as a Potential Biomarker of Alzheimer's Disease.


MeSH Terms

  • Aged
  • Alzheimer Disease
  • Biomarkers
  • Brain
  • Fatty Acids
  • Female
  • Humans
  • Male
  • Symporters

Keywords

  • Alzheimer’s disease
  • MFSD2a carrier
  • aging
  • neurologic disorders
  • omega-3 PUFA

MGMT[править]

Cytotoxic and Senolytic Effects of Methadone in Combination with Temozolomide in Glioblastoma Cells.


Keywords

  • apoptosis
  • cancer therapy
  • drug resistance
  • glioblastoma
  • methadone
  • senescence
  • temozolomide

MIA[править]

Age, cohort, and period effects on metamemory beliefs.


MeSH Terms

  • Aged
  • Aged, 80 and over
  • Aging
  • Cohort Studies
  • Cross-Sectional Studies
  • Female
  • Humans
  • Longitudinal Studies
  • Male
  • Metacognition
  • Middle Aged


Memory Age-based Stereotype Threat: Role of Locus of Control and Anxiety.


MeSH Terms

  • Aged
  • Aging
  • Anxiety
  • Female
  • Humans
  • Internal-External Control
  • Male
  • Memory, Episodic
  • Metacognition
  • Middle Aged
  • Stereotyping

MIB1[править]

Immunohistochemical detection of senescence markers in human sarcomas.


Keywords

  • SenTraGor
  • Senescence
  • p16
  • p21
  • sarcoma

MIP[править]

Inspiratory muscle training improves cerebrovascular and postural control responses during orthostatic stress in older women.


Keywords

  • Aging
  • Cardiac output
  • Center-of-pressure
  • Middle cerebral artery blood flow velocity
  • Respiratory muscles


A novel multi-marker discovery approach identifies new serum biomarkers for Parkinson's disease in older people: an EXosomes in PArkiNson Disease (EXPAND) ancillary study.


Keywords

  • Aging
  • Amino acids
  • Cytokines
  • Metabolomics
  • Neurodegeneration
  • Personalized medicine


Sexual dimorphism of physical activity on cognitive aging: Role of immune functioning.


Keywords

  • Brain aging
  • Chemokines
  • Cognitive aging
  • Exercise
  • Gender
  • Inflammation
  • Lifestyle


Comparison of balance changes after inspiratory muscle or Otago exercise training.


MeSH Terms

  • Aged
  • Aged, 80 and over
  • Aging
  • Breathing Exercises
  • Exercise
  • Exercise Therapy
  • Female
  • Humans
  • Male
  • Maximal Respiratory Pressures
  • Muscle Strength
  • Physical Endurance
  • Postural Balance
  • Respiratory Muscles
  • Respiratory Therapy

MITF[править]

Thymocid , a Standardized Black Cumin ([i]Nigella sativa[/i]) Seed Extract, Modulates Collagen Cross-Linking, Collagenase and Elastase Activities, and Melanogenesis in Murine B16F10 Melanoma Cells.


Keywords

  • Nigella sativa
  • Thymocid®
  • black cumin
  • collagen
  • collagenase
  • cosmeceutical
  • elastase
  • glycation
  • melanogenesis
  • skin aging


HuRdling Senescence: HuR Breaks BRAF-Induced Senescence in Melanocytes and Supports Melanoma Growth.


Keywords

  • HuR
  • MITF
  • Microphthalmia-associated transcription factor
  • malignant melanoma
  • oncogene induced senescence

MLH1[править]

The somatic mutation landscape of the human body.


MeSH Terms

  • Age Factors
  • Aging
  • Humans
  • Mutation
  • Neoplasms
  • Selection, Genetic
  • Sex Factors

Keywords

  • Aging
  • Cancer
  • Genomic instability
  • Human
  • Somatic evolution
  • Somatic mutation

MLKL[править]

Remifentanil preconditioning protects against hypoxia-induced senescence and necroptosis in human cardiac myocytes [i]in vitro[/i].


Keywords

  • cardiomyocytes
  • hypoxia
  • necroptosis
  • remifentanil
  • senescence

MLN[править]

Age-Dependent Decrease in the Induction of Regulatory T Cells Is Associated With Decreased Expression of RALDH2 in Mesenteric Lymph Node Dendritic Cells.


Keywords

  • RALDH2
  • aging
  • dendritic cells
  • epigenetic regulation
  • regulatory T cells
  • retinoic acid

MMD[править]

Association between a Deficit Accumulation Frailty Index and Mobility Outcomes in Older Adults: Secondary Analysis of the Lifestyle Interventions and Independence for Elders (LIFE) Study.


Keywords

  • LIFE Study
  • deficit accumulation
  • disability
  • frailty
  • healthy aging
  • mobility
  • older adults


Impact of Anticholinergic Medication Burden on Mobility and Falls in the Lifestyle Interventions for Elders (LIFE) Study.


Keywords

  • anticholinergic burden
  • falls
  • mobility
  • physical activity
  • successful aging


Impact and Lessons From the Lifestyle Interventions and Independence for Elders (LIFE) Clinical Trials of Physical Activity to Prevent Mobility Disability.


Keywords

  • aging
  • mobility disability
  • multicenter trialphysical activity

MME[править]

Geriatric Opioid Harm Reduction: Interprofessional Student Learning Outcomes.


Keywords

  • aging
  • older adults
  • opioid harm reduction
  • overdose risk


Effectiveness of local anesthetic injection in geriatric patients following operative management of proximal and diaphyseal femur fracture.


MeSH Terms

  • Aged
  • Aged, 80 and over
  • Analgesics, Opioid
  • Anesthetics, Local
  • Delirium
  • Female
  • Femoral Fractures
  • Fracture Fixation, Internal
  • Geriatrics
  • Humans
  • Injections, Intra-Articular
  • Intraoperative Care
  • Male
  • Pain Management
  • Pain, Postoperative
  • Retrospective Studies

Keywords

  • Geriatrics
  • Hip fracture
  • Local anesthetic
  • Narcotics

MMP1[править]

Reacquisition of a spindle cell shape does not lead to the restoration of a youthful state in senescent human skin fibroblasts.


Keywords

  • Cell shape
  • Fibroblast
  • Lithography
  • SASP
  • Senescence


A novel multifunctional skin care formulation with a unique blend of antipollution, brightening and antiaging active complexes.


Keywords

  • anti-wrinkle
  • pigmentation
  • pollution
  • skin aging
  • skin barrier

MMP13[править]

Aging aggravates intervertebral disc degeneration by regulating transcription factors toward chondrogenesis.


MeSH Terms

  • Aging
  • Animals
  • Antigens, Differentiation
  • Chondrocytes
  • Chondrogenesis
  • Core Binding Factor Alpha 1 Subunit
  • Fetal Proteins
  • Gene Expression Regulation
  • Intervertebral Disc Degeneration
  • Mice
  • Mice, Transgenic
  • Sp7 Transcription Factor
  • T-Box Domain Proteins

Keywords

  • Wnt/β-catenin/LRPs
  • biomechanics
  • genetic animal models
  • osterix

MOS[править]

Effect of mannan oligosaccharides on the microbiota and productivity parameters of Litopenaeus vannamei shrimp under intensive cultivation in Ecuador.


MeSH Terms

  • Actinobacteria
  • Aeromonas
  • Animal Feed
  • Animals
  • Aquaculture
  • Bacterial Adhesion
  • Ecuador
  • Flavobacteriaceae
  • Lactococcus
  • Longevity
  • Mannans
  • Microbiota
  • Oligosaccharides
  • Penaeidae
  • Proteobacteria
  • Seafood
  • Shewanella
  • Verrucomicrobia
  • Vibrio


Predictors of health-related quality of life among older adults living with HIV in Thailand: results from the baseline and follow-up surveys.


Keywords

  • Chiang Mai
  • HIV and aging
  • Older adults living with HIV
  • Thailand
  • health-related quality of life
  • quality of life


Comparison of health-related quality of life between the Han and Yi ethnicity elderly in the Yi autonomous areas of Yunnan Province.


MeSH Terms

  • Activities of Daily Living
  • Aged
  • Aged, 80 and over
  • Aging
  • China
  • Cross-Sectional Studies
  • Ethnic Groups
  • Female
  • Humans
  • Male
  • Middle Aged
  • Quality of Life

Keywords

  • ADL
  • Elderly
  • Health-related quality of life
  • IADL
  • Yi ethnic minority


Mannan oligosaccharide increases the growth performance, immunity and resistance capability against Vibro Parahemolyticus in juvenile abalone Haliotis discus hannai Ino.


MeSH Terms

  • Animal Feed
  • Animals
  • Antioxidants
  • Diet
  • Dietary Supplements
  • Dose-Response Relationship, Drug
  • Gastropoda
  • Immunity, Innate
  • Longevity
  • Mannans
  • Oligosaccharides
  • Vibrio parahaemolyticus

Keywords

  • Abalone
  • Antioxidation
  • Bacterial challenge
  • Disease resistance
  • Growth
  • Immunity
  • Mannan oligosaccharide

MPHOSPH6[править]

Genome-wide Association Analysis in Humans Links Nucleotide Metabolism to Leukocyte Telomere Length.


MeSH Terms

  • Genome-Wide Association Study
  • Humans
  • Leukocytes
  • Nucleotides
  • Telomere

Keywords

  • Mendelian randomisation
  • age-related disease
  • biological aging
  • telomere length

MPI[править]

Age-related decline of lymphatic drainage from the eye: A noninvasive in vivo photoacoustic tomography study.


Keywords

  • Age-related
  • Aging
  • Aqueous humor
  • Drainage
  • Eye
  • Glaucoma
  • Imaging
  • In vivo
  • Lymph node
  • Lymphatic
  • Mice
  • Photoacoustic tomography
  • Uveoscleral


Interest of the multidimensional prognostic index (MPI) as an assessment tool in hospitalized patients in geriatrics.


MeSH Terms

  • Aged, 80 and over
  • Female
  • Geriatric Assessment
  • Hospital Mortality
  • Hospitalization
  • Humans
  • Length of Stay
  • Male
  • Patient Readmission
  • Prognosis

Keywords

  • elderly
  • geriatrics
  • hospitalization
  • multidimensional prognostic index

MRE11[править]

Chromosomal alterations among age-related haematopoietic clones in Japan.


MeSH Terms

  • Aged, 80 and over
  • Aging
  • Alleles
  • Cell Lineage
  • Chromosome Aberrations
  • Chromosomes, Human
  • Clone Cells
  • Cohort Studies
  • Female
  • Genetic Loci
  • Genome, Human
  • Hematopoiesis
  • Hematopoietic Stem Cells
  • Humans
  • Japan
  • Leukemia, Lymphocytic, Chronic, B-Cell
  • Leukemia, T-Cell
  • Male
  • Mosaicism
  • Mutation
  • United Kingdom

MSC[править]

Rejuvenation of Senescent Endothelial Progenitor Cells by Extracellular Vesicles Derived From Mesenchymal Stromal Cells.


Keywords

  • BM, bone marrow
  • CVD, cardiovascular disease
  • EC, endothelial cell
  • EPC, endothelial progenitor cell
  • EV, extracellular vesicle
  • FBS, fetal bovine serum
  • MEM, minimum essential medium
  • MI, myocardial infarction
  • MSC, mesenchymal stromal cell
  • NTA, nanotracking analysis
  • PBS, phosphate-buffered saline
  • TEV, tailored extracellular vesicle
  • VEGF, vascular endothelial growth factor
  • acellular
  • angiogenesis
  • extracellular vesicles
  • lin− BMC, lineage negative bone marrow cell
  • miR, microRNA
  • qPCR, quantitative transcription polymerase chain reaction
  • regeneration
  • senescence


Extracellular vesicles derived from bone marrow mesenchymal stem cells enhance myelin maintenance after cortical injury in aged rhesus monkeys.


Keywords

  • Aging
  • Cortical injury
  • Extracellular vesicles
  • Monkeys
  • Myelin
  • Non-human primates
  • Oligodendrocytes
  • Stroke
  • White matter


TPP1 Enhances the Therapeutic Effects of Transplanted Aged Mesenchymal Stem Cells in Infarcted Hearts via the MRE11/AKT Pathway.


Keywords

  • DNA repair
  • aging
  • myocardial infarction
  • stem cells therapy
  • telomere


Aging-Affected MSC Functions and Severity of Periodontal Tissue Destruction in a Ligature-Induced Mouse Periodontitis Model.


Keywords

  • aging
  • bone resorption
  • immunomodulation
  • mesenchymal stem cell
  • periodontitis
  • tissue destruction


Human placenta-derived mesenchymal stem cells stimulate ovarian function via miR-145 and bone morphogenetic protein signaling in aged rats.


Keywords

  • Aging
  • Follicular development
  • Hormone biosynthesis
  • Primordial follicle activation
  • Stem cell therapy
  • miR-145


Mesenchymal Stromal Cells as Critical Contributors to Tissue Regeneration.


Keywords

  • adult stem cells
  • aging
  • mesenchymal stromal cells (MSC)
  • regenerative medicine
  • stem cell niche


The biology of human hair greying.


Keywords

  • ageing
  • endocrine
  • graying
  • melanin
  • senescence


[i]Tsc1[/i] Regulates the Proliferation Capacity of Bone-Marrow Derived Mesenchymal Stem Cells.


Keywords

  • TSC1
  • mammalian target of rapamycin (mTOR)
  • mesenchymal stem cell
  • senescence
  • stem cell proliferation
  • tuberous sclerosis


The role of mitochondrial dysfunction in mesenchymal stem cell senescence.


Keywords

  • Mesenchymal stem cells
  • Mitochondrial dysfunction
  • Mitophagy
  • Reactive oxygen species
  • Senescence


Metabolic syndrome increases senescence-associated micro-RNAs in extracellular vesicles derived from swine and human mesenchymal stem/stromal cells.


Keywords

  • EV
  • MSC
  • Metabolic syndrome
  • RNA-sequencing
  • Senescence


Functional heterogeneity of mesenchymal stem cells from natural niches to culture conditions: implications for further clinical uses.


Keywords

  • Aging diseases
  • Conditioned medium
  • Diabetes
  • Exosomes
  • Extracellular vesicles
  • Lupus
  • Regenerative medicine
  • Secretome


Functional crosstalk between mTORC1/p70S6K pathway and heterochromatin organization in stress-induced senescence of MSCs.


Keywords

  • Aging
  • Heterochromatin
  • MSC senescence
  • mTORC1/p70S6K


Increased cellular senescence in the murine and human stenotic kidney: Effect of mesenchymal stem cells.


Keywords

  • cellular senescence
  • exosomes
  • kidney
  • mesenchymal stem cells
  • renal artery obstruction


Intrinsic Type 1 Interferon (IFN1) Profile of Uncultured Human Bone Marrow CD45 CD271 Multipotential Stromal Cells (BM-MSCs): The Impact of Donor Age, Culture Expansion and IFNα and IFNβ Stimulation.


Keywords

  • aging
  • bone marrow
  • mesenchymal stromal cells
  • senescence
  • type 1 interferon


Facial rejuvenation using stem cell conditioned media combined with skin needling: A split-face comparative study.


Keywords

  • amniotic fluid stem cells products
  • dermaroller
  • facial aging
  • skin needling


Mesenchymal Stem Cell Senescence and Rejuvenation: Current Status and Challenges.


Keywords

  • autophagy
  • mesenchymal stem cells
  • mitochondrial
  • rejuvenation
  • senescence
  • telomere


The changing epigenetic landscape of Mesenchymal Stem/Stromal Cells during aging.


Keywords

  • Aging
  • DNA methylation
  • Epigenetics
  • Histome modifications
  • MSC
  • Mesenchymal Stem/Stromal Cells
  • Skeleton
  • miRNA


Dual Role of Autophagy in Regulation of Mesenchymal Stem Cell Senescence.


Keywords

  • SASP
  • general autophagy
  • mesenchymal stem cell
  • selective autophagy
  • senescence


Molecular Aspects of Adipose-Derived Stromal Cell Senescence in a Long-Term Culture: A Potential Role of Inflammatory Pathways.


Keywords

  • adipose-derived stromal/stem cell
  • aging
  • gene expression
  • long-term culture
  • senescence


Human Obesity Induces Dysfunction and Early Senescence in Adipose Tissue-Derived Mesenchymal Stromal/Stem Cells.


Keywords

  • adipose tissue
  • cellular dysfunction
  • cellular senescence
  • mesenchymal stem cells
  • obesity


miR-155-5p inhibition rejuvenates aged mesenchymal stem cells and enhances cardioprotection following infarction.


Keywords

  • mesenchymal stem cells
  • miR-155-5p
  • myocardial infarction
  • rejuvenation
  • senescence


Mesenchymal Stem Cell Derived Extracellular Vesicles in Aging.


Keywords

  • aging
  • clinical translation
  • extracellular vesicles
  • mesenchymal stem cells
  • regenerative medicine
  • senescence


Molecular Mechanisms Contributing to Mesenchymal Stromal Cell Aging.


Keywords

  • MSC senescence
  • in vitro aging
  • in vivo aging
  • mesenchymal stem/stromal cells (MSC)
  • rejuvenating strategies


Inhibition of DNA Methyltransferase by RG108 Promotes Pluripotency-Related Character of Porcine Bone Marrow Mesenchymal Stem Cells.


Keywords

  • RG108
  • apoptosis
  • pluripotency
  • porcine bone marrow mesenchymal stem cells
  • senescence


Extracellular Vesicles of Stem Cells to Prevent BRONJ.


Keywords

  • bisphosphonate-associated osteonecrosis of the jaw
  • cellular senescence
  • exosomes
  • mesenchymal stem cells
  • wound healing
  • zoledronic acid


Ginsenoside Rg1 as an Effective Regulator of Mesenchymal Stem Cells.


Keywords

  • apoptosis
  • differentiation
  • ginsenoside Rg1
  • mesenchymal stem cells
  • preclinical study
  • proliferation
  • senescence


The Importance of Stem Cell Senescence in Regenerative Medicine.


Keywords

  • Aging
  • Mesenchymal stem cell
  • Regenerative medicine


Control of mesenchymal stem cell biology by histone modifications.


Keywords

  • Cell biology
  • Cell differentiation
  • Cellular senescence
  • Epigenetics
  • Histone modifications
  • Mesenchymal stem cells


Impact of mesenchymal stem cell senescence on inflammaging.


MeSH Terms

  • Aging
  • Cellular Senescence
  • Cytokines
  • Hematopoiesis
  • Humans
  • Immunomodulation
  • Immunosenescence
  • Inflammation
  • Macrophages
  • Mesenchymal Stem Cells


Late Rescue Therapy with Cord-Derived Mesenchymal Stromal Cells for Established Lung Injury in Experimental Bronchopulmonary Dysplasia.


Keywords

  • COPD
  • aging
  • lung
  • newborn
  • regenerative medicine
  • stem cells


Low-Level Radiofrequency Exposure Does Not Induce Changes in MSC Biology: An in vitro Study for the Prevention of NIR-Related Damage.


Keywords

  • 169 MHz
  • CFU
  • senescence
  • stem cell


Macrophage migration inhibitory factor rejuvenates aged human mesenchymal stem cells and improves myocardial repair.


MeSH Terms

  • Adolescent
  • Aged
  • Aged, 80 and over
  • Aging
  • Animals
  • Animals, Newborn
  • Cellular Senescence
  • Humans
  • Macrophage Migration-Inhibitory Factors
  • Mesenchymal Stem Cell Transplantation
  • Mesenchymal Stem Cells
  • Myocardial Infarction
  • Myocardium
  • Myocytes, Cardiac
  • Rats
  • Rats, Sprague-Dawley
  • Young Adult

Keywords

  • macrophage migration inhibitory factor
  • mesenchymal stem cells
  • myocardial infarction
  • rejuvenation
  • senescence


Influence of olive oil and its components on mesenchymal stem cell biology.


Keywords

  • Aging
  • Cellular differentiation
  • Cellular niche
  • Mediterranean diet
  • Mesenchymal stem cells
  • Olive oil


Epigenetic Regulation of Mesenchymal Stem Cell Homeostasis.


Keywords

  • aging
  • epigenetics
  • fate decision
  • mesenchymal stem cells
  • pathogenesis
  • regeneration


Mesenchymal Stem Cells: Allogeneic MSC May Be Immunosuppressive but Autologous MSC Are Dysfunctional in Lupus Patients.


Keywords

  • dysfunction
  • immunoregulatory
  • mesenchymal stem cells
  • senescence
  • systemic lupus erythematosus


Effects of high glucose conditions on the expansion and differentiation capabilities of mesenchymal stromal cells derived from rat endosteal niche.


MeSH Terms

  • Adipogenesis
  • Animals
  • Biomarkers
  • Bone Regeneration
  • Bone and Bones
  • Cell Differentiation
  • Cell Proliferation
  • Cells, Cultured
  • Cellular Senescence
  • Diabetes Mellitus, Type 2
  • Glucose
  • Hyperglycemia
  • Male
  • Mesenchymal Stem Cells
  • Osteogenesis
  • Rats, Wistar

Keywords

  • Bone repair
  • Cellular senescence
  • Differentiation
  • Hyperglycaemia
  • Mesenchymal stromal cells; Endosteum
  • Type II diabetes


Autophagy inhibits the mesenchymal stem cell aging induced by D-galactose through ROS/JNK/p38 signalling.


Keywords

  • ROS/JNK/p38 signalling
  • autophagy
  • mesenchymal stem cells
  • senescence


Enhancing survival, engraftment, and osteogenic potential of mesenchymal stem cells.


Keywords

  • Anoikis
  • Bioactive scaffolds
  • Bone regeneration
  • Engraftment
  • Homing
  • Hypoxia
  • Mesenchymal stem cells
  • Osteogenesis
  • Preconditioning
  • Senescence


Mesenchymal stem cell senescence alleviates their intrinsic and seno-suppressive paracrine properties contributing to osteoarthritis development.


MeSH Terms

  • Animals
  • Cell Proliferation
  • Cells, Cultured
  • Cellular Senescence
  • Chondrocytes
  • Coculture Techniques
  • Collagenases
  • Etoposide
  • Gene Expression Regulation
  • Humans
  • Inflammation
  • Luciferases
  • Male
  • Mesenchymal Stem Cells
  • Mice
  • Mice, Inbred Strains
  • Mice, Transgenic
  • Osteoarthritis
  • Paracrine Communication

Keywords

  • mesenchymal stem cell
  • osteoarthritis
  • senescence
  • tissue homeostasis


Embryonic stem cell-derived extracellular vesicles enhance the therapeutic effect of mesenchymal stem cells.


MeSH Terms

  • Animals
  • Cell- and Tissue-Based Therapy
  • Cellular Senescence
  • Disease Models, Animal
  • Embryonic Stem Cells
  • Extracellular Vesicles
  • Humans
  • Insulin-Like Growth Factor I
  • Mesenchymal Stem Cell Transplantation
  • Mesenchymal Stem Cells
  • Mice
  • Mice, Inbred BALB C
  • Phosphatidylinositol 3-Kinases
  • Wounds and Injuries

Keywords

  • Cellular senescence
  • Embryonic stem cells
  • Extracellular vesicles
  • IGF1/PI3K/AKT pathway
  • Mesenchymal stem cells


Survival of aging CD264 and CD264 populations of human bone marrow mesenchymal stem cells is independent of colony-forming efficiency.


Keywords

  • aging
  • decoy TRAIL receptor 2 (CD264)
  • mesenchymal stem cells
  • survival


Differential effects of extracellular vesicles from aging and young mesenchymal stem cells in acute lung injury.


MeSH Terms

  • Acute Lung Injury
  • Age Factors
  • Animals
  • Disease Models, Animal
  • Extracellular Vesicles
  • Mesenchymal Stem Cell Transplantation
  • Mesenchymal Stem Cells
  • Mice
  • Treatment Outcome

Keywords

  • ARDS
  • acute lung injury
  • aging
  • extracellular vesicles
  • mesenchymal stem cells


Connexin43 is Dispensable for Early Stage Human Mesenchymal Stem Cell Adipogenic Differentiation But is Protective against Cell Senescence.


MeSH Terms

  • Adipogenesis
  • Cell Differentiation
  • Cellular Senescence
  • Connexin 43
  • Gene Expression Regulation
  • Humans
  • Mesenchymal Stem Cells
  • Time Factors

Keywords

  • CRISPR-Cas9
  • adipogenesis
  • connexin43
  • gap junctional intercellular communication
  • mesenchymal stem cells
  • oculodentodigital dysplasia
  • senescence


Maintained Properties of Aged Dental Pulp Stem Cells for Superior Periodontal Tissue Regeneration.


Keywords

  • inflammation
  • mesenchymal stem cells
  • periodontitis
  • senescence

MTHFR[править]

One-carbon metabolism supplementation improves outcome after stroke in aged male MTHFR-deficient mice.


MeSH Terms

  • Aging
  • Animals
  • Brain
  • Choline
  • Dietary Supplements
  • Male
  • Methylenetetrahydrofolate Reductase (NADPH2)
  • Mice
  • Mice, Inbred C57BL
  • Recovery of Function
  • Stroke
  • Tetrahydrofolates
  • Vitamin B 12

Keywords

  • Cerebral ischemia
  • Homocysteine
  • Methylenetetrahydrofolate reductase
  • Neurodegeneration
  • Sensorimotor cortex
  • Supplementation

MTOR[править]

The roles of MTOR and miRNAs in endothelial cell senescence.


Keywords

  • Endothelium
  • MTOR
  • MicroRNAs
  • Senescence
  • Vascular aging


Autophagy drives fibroblast senescence through MTORC2 regulation.


Keywords

  • Autophagy
  • MTORC2
  • myofibroblast
  • rapamycin
  • senescence


The GID ubiquitin ligase complex is a regulator of AMPK activity and organismal lifespan.


Keywords

  • AMPK
  • GID
  • autophagy
  • longevity
  • primary cilium
  • ubiquitination

MTR[править]

Amide proton transfer-weighted magnetic resonance imaging of human brain aging at 3 Tesla.


Keywords

  • Aging
  • amide proton transfer imaging
  • biomarkers
  • chemical exchange saturation transfer (CEST)
  • molecular imaging

MUC7[править]

Reduced Salivary Mucin Binding and Glycosylation in Older Adults Influences Taste in an In Vitro Cell Model.


MeSH Terms

  • Adolescent
  • Adult
  • Aged
  • Aging
  • Cell Line
  • Epithelial Cells
  • Female
  • Glycosylation
  • Humans
  • Male
  • Middle Aged
  • Mucins
  • N-Acetylneuraminic Acid
  • Plasmids
  • Protein Binding
  • Rheology
  • Saliva
  • Taste
  • Young Adult

Keywords

  • ageing
  • mucin
  • rheology
  • saliva
  • taste

MYB[править]

Transcriptome profiling of postharvest shoots identifies PheNAP2- and PheNAP3-promoted shoot senescence.


MeSH Terms

  • Arabidopsis
  • Arabidopsis Proteins
  • Gene Expression Profiling
  • Gene Expression Regulation, Plant
  • Plant Leaves
  • Transcriptome

Keywords 

         Phyllostachys edulis
  • NAC
  • postharvest
  • regulatory factors
  • shoot senescence

MYC[править]

Enhanced proliferative capacity of human preadipocytes achieved by an optimized cultivating method that induces transient activity of hTERT.


Keywords

  • Adipogenesis
  • Adipose-derived stromal cells
  • Senescence
  • hTERT
  • mTesR1

MYCN[править]

Silencing of AURKA augments the antitumor efficacy of the AURKA inhibitor MLN8237 on neuroblastoma cells.


Keywords

  • Aurora kinase A
  • Cellular senescence
  • MLN8237
  • Neuroblastoma
  • Small interfering RNA

MYSM1[править]

MYSM1 Suppresses Cellular Senescence and the Aging Process to Prolong Lifespan.


Keywords

  • DNA repair
  • Myb‐like, SWIRM, and MPN domains‐containing protein 1 (MYSM1)
  • aging
  • senescence
  • senescence‐associated secretory phenotype (SASP)

MYT1[править]

ESC-sEVs Rejuvenate Aging Hippocampal NSCs by Transferring SMADs to Regulate the MYT1-Egln3-Sirt1 Axis.


Keywords

  • ESC-sEVs
  • MYT1
  • aging
  • hippocampal NSCs
  • senescence

NACA[править]

Age and Sex Are Strongly Correlated to the Rate and Type of Mountain Injuries Requiring Search and Rescue Missions.


MeSH Terms

  • Adolescent
  • Adult
  • Aged
  • Aged, 80 and over
  • Aging
  • Emergency Medical Services
  • Female
  • Humans
  • Male
  • Middle Aged
  • Mountaineering
  • Rescue Work
  • Sex Factors
  • Young Adult

Keywords

  • MRT
  • NACA ICAR
  • SAR
  • injury
  • mechanism

NAMPT[править]

Over-expression of Nicotinamide phosphoribosyltransferase in mouse cells confers protective effect against oxidative and ER stress-induced premature senescence.


Keywords

  • ER stress
  • NAD+
  • NAMPT
  • oxidative stress
  • premature senescence


Resistance training increases muscle NAD and NADH concentrations as well as NAMPT protein levels and global sirtuin activity in middle-aged, overweight, untrained individuals.


Keywords

  • NAD +
  • NADH
  • aging
  • muscle
  • resistance training


Differential Expression of Human N-Alpha-Acetyltransferase 40 (hNAA40), Nicotinamide Phosphoribosyltransferase (NAMPT) and Sirtuin-1 (SIRT-1) Pathway in Obesity and T2DM: Modulation by Metformin and Macronutrient Intake.


Keywords

  • NAMPT
  • T2DM
  • hNAA40
  • nicotinamide phosphoribosyltransferase
  • obesity
  • senescence
  • sirtuin-1

NDRG2[править]

NDRG2 Expression Correlates with Neurofibrillary Tangles and Microglial Pathology in the Ageing Brain.


MeSH Terms

  • Aged
  • Aged, 80 and over
  • Aging
  • Alzheimer Disease
  • Antigens, CD
  • Antigens, Differentiation, Myelomonocytic
  • Astrocytes
  • Brain
  • DNA Damage
  • Excitatory Amino Acid Transporter 2
  • Gene Expression Regulation
  • Glial Fibrillary Acidic Protein
  • Glutamate-Ammonia Ligase
  • Humans
  • Microglia
  • Neurofibrillary Tangles
  • Tumor Suppressor Proteins
  • tau Proteins

Keywords

  • N-myc downstream regulated gene 2 (NDRG2)
  • ageing brain
  • astrocyte
  • neurofibrillary tangles

NDUFS8[править]

Mitochondrial Complex I Mutations Predispose Drosophila to Isoflurane Neurotoxicity.


MeSH Terms

  • Aging
  • Anesthetics, Inhalation
  • Animals
  • Animals, Genetically Modified
  • Drosophila
  • Electron Transport Complex I
  • Isoflurane
  • Male
  • Mitochondria
  • Mutation
  • Sevoflurane

NEDD8[править]

Targeting Protein Neddylation for Cancer Therapy.


MeSH Terms

  • Animals
  • Apoptosis
  • Autophagy
  • Cyclopentanes
  • Humans
  • NEDD8 Protein
  • Neoplasms
  • Pyrimidines
  • Ubiquitin-Protein Ligases
  • Ubiquitination

Keywords

  • Apoptosis
  • Autophagy
  • Cancer target
  • Inflammatory responses
  • Neddylation
  • Senescence


Effective targeting of the ubiquitin-like modifier NEDD8 for lung adenocarcinoma treatment.


Keywords

  • NEDD8
  • apoptosis
  • cullin-RING ligases
  • neddylation
  • senescence


Pevonedistat targeted therapy inhibits canine melanoma cell growth through induction of DNA re-replication and senescence.


Keywords

  • DNA re-replication
  • MLN4924
  • NAE-inhibitor
  • canine
  • melanoma
  • senescence

NEO1[править]

Neogenin-1 distinguishes between myeloid-biased and balanced [i]Hoxb5[/i] mouse long-term hematopoietic stem cells.


MeSH Terms

  • Aging
  • Animals
  • Female
  • Hematopoietic Stem Cell Transplantation
  • Hematopoietic Stem Cells
  • Homeodomain Proteins
  • Membrane Proteins
  • Mice
  • Mice, Transgenic

Keywords

  • Neogenin-1
  • aging
  • hematopoietic stem cell
  • myeloid bias
  • transplantation

NES[править]

Mini-review: Aging of the neuroendocrine system: Insights from nonhuman primate models.


Keywords

  • Aging
  • Neuroendocrine system
  • Nonhuman primate

NFKB1[править]

NFKB1 gene single-nucleotide polymorphisms: implications for graft-versus-host disease in allogeneic hematopoietic stem cell transplantation.


MeSH Terms

  • Adult
  • Allografts
  • Disease-Free Survival
  • Female
  • Graft vs Host Disease
  • Hematopoietic Stem Cell Transplantation
  • Humans
  • Male
  • Middle Aged
  • NF-kappa B p50 Subunit
  • Pilot Projects
  • Polymorphism, Single Nucleotide
  • Survival Rate

Keywords

  • Allogeneic hematopoietic stem cell transplantation
  • Cellular senescence
  • Graft-versus-host disease
  • NFKB1 gene
  • Senescence-associated secretory phenotype
  • Single-nucleotide polymorphism

NGF[править]

Dietary fish hydrolysate supplementation containing n-3 LC-PUFAs and peptides prevents short-term memory and stress response deficits in aged mice.


Keywords

  • Aging
  • Anxiety-like behaviour
  • Cognitive decline
  • Hydrolysate
  • Low molecular weight peptides
  • Marine by-products
  • Memory
  • Navigation strategies
  • Neuroinflammation
  • Stress response
  • n-3 Long chain polyunsaturated fatty acids (n-3 LC-PUFAs)


Imbalance of nerve growth factor metabolism in aging women with overactive bladder syndrome.


Keywords

  • Aging female
  • MMP-7
  • MMP-9
  • Nerve growth factor
  • Overactive bladder
  • proNGF


Parity Attenuates Intraepithelial Corneal Sensory Nerve Loss in Female Mice.


Keywords

  • aging
  • corneal epithelial cell proliferation
  • corneal sensitivity
  • corneal sensory nerves
  • mouse
  • parity
  • pregnancy


Cholinergic System and NGF Receptors: Insights from the Brain of the Short-Lived Fish [i]Nothobranchius furzeri[/i].


Keywords

  • NTRK1/NTRKA
  • aging
  • cholinergic system
  • fish
  • p75/NGFR


Retrograde axonal transport of BDNF and proNGF diminishes with age in basal forebrain cholinergic neurons.


MeSH Terms

  • Aging
  • Alzheimer Disease
  • Axonal Transport
  • Brain-Derived Neurotrophic Factor
  • Cholinergic Neurons
  • Humans
  • Nerve Growth Factor
  • Prosencephalon

Keywords

  • Alzheimer's disease
  • Axonal transport
  • Basal forebrain
  • Neurodegeneration
  • Neurotrophins
  • Trk receptors


C-SH2 point mutation converts p85β regulatory subunit of phosphoinositide 3-kinase to an anti-aging gene.


MeSH Terms

  • Aging
  • Animals
  • Blood Glucose
  • Class I Phosphatidylinositol 3-Kinases
  • Class Ia Phosphatidylinositol 3-Kinase
  • Female
  • Forkhead Transcription Factors
  • Insulin
  • Male
  • Mice
  • Mice, Inbred C57BL
  • Mice, Transgenic
  • Nerve Growth Factor
  • Oxidative Stress
  • PC12 Cells
  • Platelet-Derived Growth Factor
  • Point Mutation
  • Proto-Oncogene Proteins c-akt
  • Rats
  • src Homology Domains

NHS[править]

Telomerase Activation to Reverse Immunosenescence in Elderly Patients With Acute Coronary Syndrome: Protocol for a Randomized Pilot Trial.


Keywords

  • acute coronary syndrome
  • coronary heart disease
  • immunosenescence
  • telomerase activator


Factors associated with COVID-19-related death using OpenSAFELY.


MeSH Terms

  • Adolescent
  • Adult
  • African Continental Ancestry Group
  • Age Distribution
  • Age Factors
  • Aged
  • Aged, 80 and over
  • Aging
  • Asian Continental Ancestry Group
  • Asthma
  • Betacoronavirus
  • COVID-19
  • Cohort Studies
  • Coronavirus Infections
  • Diabetes Mellitus
  • Female
  • Humans
  • Hypertension
  • Male
  • Middle Aged
  • Pandemics
  • Pneumonia, Viral
  • Proportional Hazards Models
  • Risk Assessment
  • SARS-CoV-2
  • Sex Characteristics
  • Smoking
  • State Medicine
  • Young Adult


Advanced ophthalmic nurse practitioners: the potential to improve outcomes for older people with cataracts.


Keywords

  • advanced practice
  • gerontology
  • older people
  • patient outcomes
  • patients
  • practice development
  • professional
  • professional issues
  • quality of life


Patient Satisfaction in the Spanish National Health Service: Partial Least Squares Structural Equation Modeling.


MeSH Terms

  • Cross-Sectional Studies
  • Gross Domestic Product
  • Health Care Rationing
  • Health Expenditures
  • Humans
  • Latent Class Analysis
  • Least-Squares Analysis
  • Life Expectancy
  • Patient Safety
  • Patient Satisfaction
  • Spain
  • State Medicine

Keywords

  • National Health Service
  • health policy
  • partial least squares structural equation modeling (PLS-SEM)
  • patient satisfaction
  • quality of healthcare


Heart failure with preserved ejection fraction (HFpEF) pathophysiology study (IDENTIFY-HF): does increased arterial stiffness associate with HFpEF, in addition to ageing and vascular effects of comorbidities? Rationale and design.


MeSH Terms

  • Aged
  • Aged, 80 and over
  • Aging
  • Biomarkers
  • Comorbidity
  • Diabetes Mellitus
  • Echocardiography
  • Exercise Tolerance
  • Female
  • Heart Failure
  • Heart Ventricles
  • Humans
  • Hypertension
  • Male
  • Observational Studies as Topic
  • Prospective Studies
  • Pulse Wave Analysis
  • Research Design
  • Stroke Volume
  • Vascular Stiffness

Keywords

  • arterial stiffness
  • comorbidities
  • heart failure with preserved ejection fraction
  • pathophysiology


Challenges to concordance: theories that explain variations in patient responses.


MeSH Terms

  • Aging
  • Benchmarking
  • Communication Barriers
  • Community Health Nursing
  • Humans
  • Nurse-Patient Relations
  • State Medicine
  • United Kingdom

Keywords

  • Concordance
  • Decision making
  • Person-centred care
  • Psychological theories
  • Self-management


Optimism is associated with exceptional longevity in 2 epidemiologic cohorts of men and women.


MeSH Terms

  • Adult
  • Aged
  • Aged, 80 and over
  • Aging
  • Female
  • Health Behavior
  • Humans
  • Logistic Models
  • Longevity
  • Longitudinal Studies
  • Male
  • Middle Aged
  • Odds Ratio

Keywords

  • aging
  • longevity
  • longitudinal study
  • optimism
  • psychological well-being

NKAP[править]

NKAP Regulates Senescence and Cell Death Pathways in Hematopoietic Progenitors.


Keywords

  • NKAP
  • apoptosis
  • cyclin dependent kinase inhibitor
  • hematopoiesis
  • senescence

NKX6-1[править]

The dynamic methylome of islets in health and disease.


MeSH Terms

  • Animals
  • Cell Differentiation
  • DNA Methylation
  • Diabetes Mellitus, Type 2
  • Epigenome
  • Humans
  • Insulin-Secreting Cells

Keywords

  • Aging
  • Beta cells
  • DNA methylation
  • Endocrine pancreas
  • Epigenetics

NLRC4[править]

Hyperglycemia-induced inflamm-aging accelerates gingival senescence via NLRC4 phosphorylation.


MeSH Terms

  • Aging
  • Animals
  • Apoptosis Regulatory Proteins
  • Blotting, Western
  • Calcium-Binding Proteins
  • Cellular Senescence
  • Clustered Regularly Interspaced Short Palindromic Repeats
  • Gingiva
  • Glucose
  • Hyperglycemia
  • Immunohistochemistry
  • Inflammation
  • Interferon Regulatory Factors
  • Male
  • Mice
  • Mice, Inbred C57BL
  • RAW 264.7 Cells
  • Signal Transduction

Keywords

  • NLRC4
  • SASP
  • aging
  • cellular senescence
  • diabetes
  • gingiva
  • hyperglycemia
  • inflamm-aging
  • inflammasome
  • inflammation

NLRP12[править]

Persistent DNA damage-induced NLRP12 improves hematopoietic stem cell function.


Keywords

  • Aging
  • DNA repair
  • Hematology
  • Hematopoietic stem cells

NLRP3[править]

Innate and Adaptive Immunity in Aging and Longevity: The Foundation of Resilience.


Keywords

  • adaptive immunity
  • aging
  • innate immunity
  • longevity
  • resilience


TET2-Loss-of-Function-Driven Clonal Hematopoiesis Exacerbates Experimental Insulin Resistance in Aging and Obesity.


Keywords

  • CHIP
  • IL-1β
  • TET2
  • adipose tissue
  • aging
  • clonal hematopoiesis
  • diabetes
  • insulin resistance
  • obesity
  • somatic mutations


Repeated propofol exposure-induced neuronal damage and cognitive impairment in aged rats by activation of NF-κB pathway and NLRP3 inflammasome.


Keywords

  • Aging
  • Apoptosis
  • NOD-like receptor protein 3 inflammasome
  • Neuroinflammation
  • Postoperative cognitive dysfunction
  • Propofol


A Small Molecule Stabilizer of the MYC G4-Quadruplex Induces Endoplasmic Reticulum Stress, Senescence and Pyroptosis in Multiple Myeloma.


Keywords

  • ASC and pannexin 1
  • MYC G4-quadruplex stabilizer
  • NLRP3
  • caspase 1
  • endoplasmic reticulum stress
  • gasdermin D
  • inflammasome
  • pyroptosis
  • senescence


Interleukin-1β Drives Cellular Senescence of Rat Astrocytes Induced by Oligomerized Amyloid β Peptide and Oxidative Stress.


Keywords

  • Alzheimer's disease
  • amyloid β
  • astrocyte
  • interleukin-1β
  • neuroinflammation
  • senescence
  • tau


Mechanisms of NLRP3 priming in inflammaging and age related diseases.


Keywords

  • Aging
  • Inflammaging
  • Inflammasome
  • NLRP3
  • Priming
  • Senescence


Lamivudine Inhibits [i]Alu[/i] RNA-induced Retinal Pigment Epithelium Degeneration via Anti-inflammatory and Anti-senescence Activities.


Keywords

  • NLRP3 inflammasome
  • age-related macular degeneration
  • lamivudine
  • retinal pigment epithelium
  • senescence


The NLRP3 Inflammasome: Metabolic Regulation and Contribution to Inflammaging.


Keywords

  • NLRP3 inflammasome
  • aging
  • inflammation
  • metabolism
  • mitochondria


Aging aggravated liver ischemia and reperfusion injury by promoting STING-mediated NLRP3 activation in macrophages.


Keywords

  • aging
  • and reperfusion injury
  • leucine-rich repeat containing protein 3
  • liver ischemia
  • macrophage immune response
  • nucleotide-binding domain
  • stimulator of interferon genes


Targeting NLRP3 Inflammasome Reduces Age-Related Experimental Alveolar Bone Loss.


Keywords

  • aging
  • inflammasomes
  • inflammation
  • macrophages
  • osteoclasts
  • periodontitis


Korean Red Ginseng Suppresses the Expression of Oxidative Stress Response and NLRP3 Inflammasome Genes in Aged C57BL/6 Mouse Ovaries.


Keywords

  • Korean ginseng extract
  • NLRP3 inflammasome
  • aging
  • ovary
  • oxidative stress response
  • subfertility


Cepharanthine promotes the effect of dexmedetomidine on the deposition of β-amyloid in the old age of the senile dementia rat model by regulating inflammasome expression.


MeSH Terms

  • Aging
  • Animals
  • Benzylisoquinolines
  • Brain
  • Dexmedetomidine
  • Inflammasomes
  • Inflammation
  • Male
  • Mitochondria
  • Oxidative Stress
  • Rats, Sprague-Dawley
  • Reactive Oxygen Species

Keywords

  • dementia
  • dexmedetomidine
  • inflammasomes
  • β-amyloid
  • cepharanthine


Ginsenoside Rg1 ameliorates glomerular fibrosis during kidney aging by inhibiting NOX4 and NLRP3 inflammasome activation in SAMP8 mice.


Keywords

  • Ginsenoside Rg1
  • Kidney aging
  • NADPH oxidase 4 (NOX4)
  • NLRP3 inflammasome
  • Renal fibrosis


Blockade of the NLRP3 inflammasome improves metabolic health and lifespan in obese mice.


Keywords

  • Aging
  • Autophagy
  • High-fat diet
  • Longevity
  • NLRP3 inflammasome
  • Obesity


Autophagy and NLRP3 inflammasome crosstalk in neuroinflammation in aged bovine brains.


Keywords

  • NLRP3 inflammasome
  • aging
  • autophagy
  • bovine
  • immunosenescence
  • neuroinflammation


NLRP3 Inflammasome Inhibition by MCC950 in Aged Mice Improves Health via Enhanced Autophagy and PPARα Activity.


Keywords

  • Aging
  • Autophagy
  • MCC950
  • NLRP3 inflammasome
  • PPARα


NLRP3 inflammasome suppression improves longevity and prevents cardiac aging in male mice.


Keywords

  • NLRP3-inflammasome
  • autophagy
  • cardiac aging
  • longevity
  • morbidity
  • mortality


Reduced NRF2 expression suppresses endothelial progenitor cell function and induces senescence during aging.


MeSH Terms

  • Aging
  • Animals
  • Cellular Senescence
  • Endothelial Progenitor Cells
  • Mice
  • NF-E2-Related Factor 2
  • NF-kappa B
  • NLR Family, Pyrin Domain-Containing 3 Protein
  • Neovascularization, Physiologic
  • Oxidative Stress

Keywords

  • NLRP3 inflammasome
  • NRF2
  • aging
  • endothelial progenitor cells
  • oxidative stress


Effect of Aging on Taurine Transporter (TauT) Expression in the Mouse Brain Cortex.


MeSH Terms

  • Aging
  • Animals
  • Brain
  • Membrane Glycoproteins
  • Membrane Transport Proteins
  • Mice
  • Mice, Inbred C57BL
  • Taurine

Keywords

  • Age-related diseases
  • Glycine Transporter (GLYT)
  • NLRP3
  • Taurine Transporter (TauT)

NMI[править]

Age-Dependent Control of Shoulder Muscles During a Reach-and-Lift Task.


Keywords

  • activity of daily living
  • aging
  • functional connectivity
  • motor variability
  • muscle fatigue

NMS[править]

Uncontrolled Diabetes as an Associated Factor with Dynapenia in Adults Aged 50 Years or Older: Sex Differences.


Keywords

  • Aging
  • Dynapenia
  • Glycated hemoglobin
  • Hyperglycemia
  • Neuromuscular strength

NMUR1[править]

[Medicinal Chemistry Focused on Mid-sized Peptides Derived from Biomolecules].


MeSH Terms

  • Aging
  • Chemistry, Pharmaceutical
  • Drug Discovery
  • Humans
  • Life Style
  • Molecular Targeted Therapy
  • Muscle Weakness
  • Muscular Atrophy
  • Myostatin
  • Neuropeptides
  • Obesity
  • Peptides
  • Receptors, Neurotransmitter
  • Structure-Activity Relationship

Keywords

  • myostatin inhibitor
  • neuromedin U receptor-selective agonist
  • peptide

NNT[править]

Yoga, Health-Related Quality of Life and Mental Well-Being: A Re-analysis of a Meta-analysis Using the Quality Effects Model.


Keywords

  • Outcomes
  • Physical activity
  • Successful aging
  • Systematic review


Statins After Myocardial Infarction in the Oldest: A Cohort Study in the Clinical Practice Research Datalink Database.


MeSH Terms

  • Aged
  • Aged, 80 and over
  • Case-Control Studies
  • Databases, Factual
  • Female
  • Humans
  • Hydroxymethylglutaryl-CoA Reductase Inhibitors
  • Male
  • Myocardial Infarction
  • Proportional Hazards Models
  • Retrospective Studies
  • Risk Assessment
  • Secondary Prevention
  • Stroke

Keywords

  • geriatrics
  • myocardial infarction
  • secondary prevention
  • statin
  • time varying

NOP10[править]

Pseudouridylation defect due to [i]DKC1[/i] and [i]NOP10[/i] mutations causes nephrotic syndrome with cataracts, hearing impairment, and enterocolitis.


MeSH Terms

  • Animals
  • Cataract
  • Cell Cycle Proteins
  • Child
  • Enterocolitis
  • Female
  • Genetic Predisposition to Disease
  • Hearing Loss, Sensorineural
  • Humans
  • Longevity
  • Male
  • Models, Molecular
  • Molecular Dynamics Simulation
  • Mutation
  • Nephrotic Syndrome
  • Nuclear Proteins
  • Pedigree
  • Protein Conformation
  • RNA, Ribosomal
  • Ribonucleoproteins, Small Nucleolar
  • Zebrafish

Keywords

  • H/ACA snoRNP
  • pediatrics
  • pseudouridylation
  • rRNA
  • telomere

NOS1[править]

Prepubertal overexposure to manganese induce precocious puberty through GABA receptor/nitric oxide pathway in immature female rats.


MeSH Terms

  • Aging
  • Animals
  • Chlorides
  • Endocrine Disruptors
  • Female
  • Gonadotropin-Releasing Hormone
  • Manganese Compounds
  • Neurons
  • Nitric Oxide
  • Ovary
  • Preoptic Area
  • Rats
  • Rats, Sprague-Dawley
  • Receptors, GABA-A
  • Sexual Maturation
  • Signal Transduction
  • Uterus
  • Weaning

Keywords

  • GABA(A)R
  • GnRH
  • Manganese
  • Nitric oxide
  • Precocious puberty

NOS3[править]

Application of Oxidative Stress to a Tissue-Engineered Vascular Aging Model Induces Endothelial Cell Senescence and Activation.


Keywords

  • endothelial cells
  • oxidative stress
  • senescence
  • tissue-engineered blood vessel
  • vascular smooth muscle cells

NOTCH1[править]

[How Does Aging Contribute to Cancer?]


MeSH Terms

  • Aged
  • Aging
  • Carcinogenesis
  • Esophageal Neoplasms
  • Humans
  • Mutation


H19 is not hypomethylated or upregulated with age or sex in the aortic valves of mice.


MeSH Terms

  • Aging
  • Animals
  • Aortic Valve
  • Aortic Valve Stenosis
  • Calcinosis
  • DNA Methylation
  • Female
  • Male
  • Mice
  • Mice, Inbred C57BL
  • RNA, Long Noncoding
  • Sex Factors
  • Up-Regulation

Keywords

H19

  • age
  • calcific aortic valve disease
  • epigenetics

NOTCH4[править]

Age-dependent autophagy induction after injury promotes axon regeneration by limiting NOTCH.


Keywords

  • Aging
  • DLK
  • LC3
  • Notch signaling
  • autophagy
  • axon injury
  • axon regeneration

NOX4[править]

Sestrin2 Attenuates Cellular Senescence by Inhibiting NADPH Oxidase 4 Expression.


Keywords

  • NOX4
  • Reactive oxygen species
  • Senescence
  • Sestrin2

NPM1[править]

Flow cytometric identification and cell-line establishment of macrophages in naked mole-rats.


MeSH Terms

  • Animals
  • Cell Line
  • Cell Proliferation
  • Cell Separation
  • Culture Media
  • Flow Cytometry
  • Longevity
  • Macrophage Colony-Stimulating Factor
  • Macrophages
  • Mole Rats
  • Recombinant Proteins

NPR1[править]

The NPR1-WRKY46-WRKY6 signaling cascade mediates probenazole/salicylic acid-elicited leaf senescence in Arabidopsis thaliana.


Keywords

  • Leaf senescence
  • NPR1
  • Probenazole
  • Salicylic acid
  • WRKY46
  • WRKY6


Loss of proton/calcium exchange 1 results in the activation of plant defense and accelerated senescence in Arabidopsis.


Keywords

  • Early senescence
  • H(+)/Ca(2+)exchanger 1
  • Plant defense
  • Salicylic acid
  • Scopoletin

NPW[править]

Novel information processing at work across time is associated with cognitive change in later life: A 14-year longitudinal study.


MeSH Terms

  • Aged
  • Aging
  • Cognition
  • Cognitive Aging
  • Cognitive Dysfunction
  • Employment
  • Female
  • Humans
  • Longitudinal Studies
  • Male
  • Middle Aged
  • Retirement
  • Time

NPY[править]

Neuropeptide Y Enhances Progerin Clearance and Ameliorates the Senescent Phenotype of Human Hutchinson-Gilford Progeria Syndrome Cells.


Keywords

  • Autophagy
  • Caloric restriction mimetic
  • Cellular senescence
  • Human aging


Effects of rikkunshito supplementation on resistance to oxidative stress and lifespan in mice.


MeSH Terms

  • Animals
  • Caloric Restriction
  • Dietary Supplements
  • Drugs, Chinese Herbal
  • Female
  • Ghrelin
  • Longevity
  • Male
  • Mice
  • Mice, Knockout
  • Oxidative Stress

Keywords

  • calorie restriction
  • ghrelin
  • longevity
  • metabolism
  • oxidative stress

NRAS[править]

Senescent cholangiocytes release extracellular vesicles that alter target cell phenotype via the epidermal growth factor receptor.


Keywords

  • biliary epithelial cell
  • cellular senescence
  • extracellular vesicles
  • primary sclerosing cholangitis
  • senescence-associated secretory phenotype


STAT3 Relays a Differential Response to Melanoma-Associated [i]NRAS[/i] Mutations.


Keywords

  • NRAS
  • STAT3
  • melanoma
  • mutation
  • oncogene-induced senescence


Cooperation of Dnmt3a R878H with Nras G12D promotes leukemogenesis in knock-in mice: a pilot study.


MeSH Terms

  • Animals
  • Apoptosis
  • Carcinogenesis
  • Cell Differentiation
  • DNA (Cytosine-5-)-Methyltransferases
  • Disease Models, Animal
  • Disease Progression
  • Gene Expression Regulation, Neoplastic
  • Gene Knock-In Techniques
  • Leukemia, Myeloid, Acute
  • Longevity
  • Mice
  • Mice, Inbred C57BL
  • Mice, Transgenic
  • Monomeric GTP-Binding Proteins
  • Mutation
  • Phenotype
  • Pilot Projects
  • Proto-Oncogene Proteins c-myc
  • RNA-Seq
  • Transcription, Genetic

Keywords

  • Acute myeloid leukemia
  • DNMT3A mutation
  • Myc activation
  • Nras G12D

NRL[править]

Development of a cyclophosphamide stress test to predict resilience to aging in mice.


Keywords

  • Aging mice
  • Cyclophosphamide
  • Neutrophil lymphocyte ratio
  • Resilience to aging
  • Stress test
  • WBC count

NRM[править]

Association between Clonal Hematopoiesis and Late Nonrelapse Mortality after Autologous Hematopoietic Cell Transplantation.


MeSH Terms

  • Adult
  • Age Factors
  • Aged
  • Aging
  • Autografts
  • Female
  • Hematopoiesis
  • Hematopoietic Stem Cell Transplantation
  • Humans
  • Lymphoma, Non-Hodgkin
  • Male
  • Middle Aged
  • Multiple Myeloma
  • Retrospective Studies

Keywords

  • Autologous
  • Clonal hematopoiesis
  • Lymphoma
  • Multiple myeloma
  • Nonrelapse mortality
  • Survivors
  • Transplantation

NSF[править]

Effects of air pollution on children from a socioecological perspective.


MeSH Terms

  • Air Pollution
  • Child Mortality
  • Child, Preschool
  • Environment
  • Humans
  • Income
  • Infant
  • Life Expectancy
  • Retrospective Studies
  • Socioeconomic Factors
  • Sociological Factors

Keywords

  • Deaths of children under age 5
  • Electrification rates
  • Income
  • Inequality in life expectancy
  • Natural resource depletion
  • Non-solid fuel
  • Outdoor and indoor air pollution
  • Socioecological perspective

NT5E[править]

The NT5E gene variant strongly affects the degradation rate of inosine 5'-monophosphate under postmortem conditions in Japanese Black beef.


MeSH Terms

  • 5'-Nucleotidase
  • Animals
  • Cattle
  • Diaphragm
  • Food Handling
  • Inosine Monophosphate
  • Muscle, Skeletal
  • Polymorphism, Single Nucleotide
  • Postmortem Changes
  • Red Meat
  • Taste

Keywords

  • Inosine 5′-monophosphate
  • Japanese Black beef
  • Meat quality
  • NT5E
  • Postmortem aging

NTHL1[править]

Mitochondrial base excision repair positively correlates with longevity in the liver and heart of mammals.


Keywords

  • AP endonuclease
  • Aging
  • DNA glycosylases
  • DNA repair
  • Mitochondria

NUCB2[править]

Ontogenetic Pattern Changes of Nucleobindin-2/Nesfatin-1 in the Brain and Intestinal Bulb of the Short Lived African Turquoise Killifish.


Keywords

  • Nesf-1
  • Nothobranchius furzeri
  • aging
  • brain-gut axis
  • vertebrate

OGA[править]

NPGPx-Mediated Adaptation to Oxidative Stress Protects Motor Neurons from Degeneration in Aging by Directly Modulating O-GlcNAcase.


MeSH Terms

  • Aging
  • Amyotrophic Lateral Sclerosis
  • Animals
  • Female
  • Humans
  • Mice
  • Mice, Mutant Strains
  • Motor Neurons
  • Muscle Denervation
  • Oxidative Stress
  • Paralysis
  • beta-N-Acetylhexosaminidases

Keywords

  • ALS
  • NPGPx
  • O-GlcNAcylation
  • OGA
  • aging
  • motor neuron
  • oxidative stress

OGG1[править]

Advanced Age Is Associated with Iron Dyshomeostasis and Mitochondrial DNA Damage in Human Skeletal Muscle.


MeSH Terms

  • Adult
  • Aged
  • Aged, 80 and over
  • Aging
  • DNA, Mitochondrial
  • Female
  • Homeostasis
  • Humans
  • Inflammation
  • Iron
  • Male
  • Mitochondria, Muscle
  • Quadriceps Muscle
  • Young Adult

Keywords

  • ZIP
  • ferritin
  • hepcidin
  • inflammation
  • iron overload
  • mitochondrial dysfunction
  • mtDNA
  • muscle aging
  • physical performance
  • transferrin

OGT[править]

ELT-2 promotes O-GlcNAc transferase OGT-1 expression to modulate Caenorhabditis elegans lifespan.


Keywords

  • Caenorhabditis elegans
  • GATA factor ELT-2
  • OGT-1
  • lifespan


Neuronal O-GlcNAcylation Improves Cognitive Function in the Aged Mouse Brain.


MeSH Terms

  • Acetylglucosamine
  • Acylation
  • Aging
  • Animals
  • Cognition
  • Male
  • Mice
  • Mice, Knockout
  • N-Acetylglucosaminyltransferases

Keywords

  • O-GlcNAcylation
  • OGT
  • aging
  • brain
  • cognition
  • hippocampus
  • rejuvenation
  • synaptic plasticity

OSM[править]

Age Differences in Sexual Minority Stress and the Importance of Friendship in Later Life.


Keywords

  • LGBT
  • Sexual minorities
  • cohort differences
  • discrimination
  • friendship aging
  • internalized homonegativity
  • minority stress
  • outness
  • social support

OTC[править]

Age and growth of stocked juvenile Shoal Bass in a tailwater: Environmental variation and accuracy of daily age estimates.


MeSH Terms

  • Aging
  • Animals
  • Bass
  • Ecosystem
  • Environmental Monitoring
  • Population Dynamics
  • Reproduction
  • Rivers

P2RY12[править]

Potential caveats of putative microglia-specific markers for assessment of age-related cerebrovascular neuroinflammation.


Keywords

  • Aging
  • Brain infiltrating myeloid cells
  • CD45
  • Cerebral amyloid angiopathy
  • Microglia
  • Neuroinflammation
  • P2RY12
  • Stroke
  • Tmem119


Microglial changes in the early aging stage in a healthy retina and an experimental glaucoma model.


Keywords

  • Aging
  • CD68
  • Glaucoma
  • Iba-1
  • Inflammation
  • MHCII
  • Microglia
  • Mouse
  • Ocular hypertension
  • P2RY12
  • Retina


Patterns of Expression of Purinergic Receptor P2RY12, a Putative Marker for Non-Activated Microglia, in Aged and Alzheimer's Disease Brains.


MeSH Terms

  • Aging
  • Alzheimer Disease
  • Biomarkers
  • Brain
  • Humans
  • Immunohistochemistry
  • Inflammation
  • Macrophages
  • Microglia
  • Phenotype
  • Plaque, Amyloid
  • Receptors, Purinergic P2Y2

Keywords

  • Alzheimer’s disease
  • activation phenotypes
  • amyloid
  • immunohistochemistry
  • microglia
  • neuroinflammation
  • temporal cortex

P4HA2[править]

Expanding the Phenotypic and Genotypic Landscape of Nonsyndromic High Myopia: A Cross-Sectional Study in 731 Chinese Patients.


MeSH Terms

  • Adolescent
  • Adult
  • Aged
  • Aged, 80 and over
  • Aging
  • Asian Continental Ancestry Group
  • Axial Length, Eye
  • Child
  • Child, Preschool
  • China
  • Cross-Sectional Studies
  • DNA Mutational Analysis
  • Female
  • Genetic Association Studies
  • Genotype
  • Humans
  • Male
  • Middle Aged
  • Myopia, Degenerative
  • Phenotype
  • Retinal Diseases
  • Vision, Low
  • Young Adult

P4HA3[править]

Age-associated genes in human mammary gland drive human breast cancer progression.


MeSH Terms

  • Adult
  • Age Factors
  • Aged
  • Aged, 80 and over
  • Animals
  • Biomarkers, Tumor
  • Breast
  • Breast Neoplasms
  • Disease Progression
  • Dyneins
  • Female
  • Gene Expression Regulation, Neoplastic
  • Heterografts
  • Humans
  • Mice
  • Mice, Inbred NOD
  • Mice, SCID
  • Middle Aged
  • Procollagen-Proline Dioxygenase
  • Prognosis
  • Survival Rate
  • Tumor Cells, Cultured

Keywords

  • ALX4
  • Aging
  • Breast cancer
  • DYNLT3
  • Gene expression
  • P4HA3
  • Relapse-free survival
  • Transcriptomics
  • Tumor progression

PAH[править]

Changes in light absorption by brown carbon in soot particles due to heterogeneous ozone aging in a smog chamber.


MeSH Terms

  • Aerosols
  • Biomass
  • Carbon
  • Ozone
  • Smog
  • Soot

Keywords

  • Absorption Ångström exponent
  • Brown carbon
  • Light absorption
  • Ozone aging
  • Soot particles


Factors associated with pulmonary arterial hypertension (PAH) in systemic sclerosis (SSc).


MeSH Terms

  • Aging
  • Humans
  • Natriuretic Peptide, Brain
  • Pulmonary Arterial Hypertension
  • Risk Factors
  • Scleroderma, Systemic


Potentially Avoidable Hospitalization among Long-Term Care Insurance Beneficiaries with Dementia.


Keywords

  • Aging
  • Dementia
  • Long-Term Care

PAM[править]

Relationship between patient activation measurement and self-rated health in patients with chronic diseases.


Keywords

  • Aging population
  • Chronic diseases
  • Patient activation measurement
  • Primary health care
  • Self-rated health


Reversal of Age-Related Neuronal Atrophy by α5-GABAA Receptor Positive Allosteric Modulation.


Keywords

  • GABA
  • aging
  • cognition
  • neurotrophic effect
  • positive allosteric modulator


The ratio of prematurely aging to non-prematurely aging mice cohabiting, conditions their behavior, immunity and lifespan.


MeSH Terms

  • Aging
  • Aging, Premature
  • Animals
  • Behavior, Animal
  • Female
  • Housing, Animal
  • Longevity
  • Lymphocytes
  • Macrophages
  • Mice
  • Oxidative Stress
  • Social Environment

Keywords

  • Behavior
  • Immunity
  • Mean lifespan
  • Prematurely aging mice
  • Social environmental strategy

PAX8[править]

Inadequate control of thyroid hormones sensitizes to hepatocarcinogenesis and unhealthy aging.


MeSH Terms

  • Aging
  • Animals
  • Fatty Liver
  • Insulin Resistance
  • Liver
  • Liver Neoplasms
  • Male
  • Mice
  • Mice, Knockout
  • PAX8 Transcription Factor
  • Thyroid Hormones

Keywords

  • glucose metabolism
  • healthspan
  • hyperthyroidism
  • hypothyroidism
  • lifespan
  • thyroid hormones

PBX1[править]

Internalization of the TAT-PBX1 fusion protein significantly enhances the proliferation of human hair follicle-derived mesenchymal stem cells and delays their senescence.


Keywords

  • AKT
  • Hair follicle mesenchymal stem cells
  • PBX1
  • Protein purification
  • Senescence
  • TAT

PC[править]

Blended home-based exercise and dietary protein in community-dwelling older adults: a cluster randomized controlled trial.


Keywords

  • Aging
  • Behaviour change
  • Physical functioning
  • Protein
  • Sarcopenia
  • e-Health


Right ventricular diastolic function in aging: a head-to-head comparison between phase-contrast MRI and Doppler echocardiography.


Keywords

  • Aging
  • Diastolic function
  • Phase-contrast MRI
  • Right ventricle


Pulse Width and Implantable Pulse Generator Longevity in Pallidal Deep Brain Stimulation for Dystonia: A Population-Based Comparative Effectiveness Study.


Keywords

  • Deep brain stimulation
  • Dystonia
  • Globus pallidus internus
  • Pulse generator longevity
  • Pulse width


Gemcitabine plus nab-paclitaxel with initial dose reduction for older patients with advanced pancreatic cancer.


Keywords

  • Adverse events
  • Chemotherapy
  • Gemcitabine
  • Geriatrics
  • Nab-paclitaxel
  • Pancreatic cancer


Protective effects of 17-β-oestradiol and phytoestrogen on age-induced oxidative stress and inhibition of surfactant synthesis in rat type II pneumocytes.


Keywords

  • 17-β-Oestradiol
  • aging
  • oxidative stress
  • phytoestrogen
  • surfactant
  • type ii pneumocytes


Pacing During 200-m Competitive Masters Swimming.


MeSH Terms

  • Adult
  • Age Factors
  • Aged
  • Aged, 80 and over
  • Aging
  • Athletes
  • Athletic Performance
  • Competitive Behavior
  • Female
  • Humans
  • Male
  • Middle Aged
  • Sex Factors
  • Swimming


Prostate cancer in Pennsylvania: The role of older age at diagnosis, aggressiveness, and environmental risk factors on treatment and mortality using data from the Pennsylvania Cancer Registry.


Keywords

  • aging
  • behavioral risk factors
  • geriatric oncology
  • healthy aging
  • prostate cancer survivorship


Extracranial versus intracranial hydro-hemodynamics during aging: a PC-MRI pilot cross-sectional study.


MeSH Terms

  • Aged
  • Aged, 80 and over
  • Brain
  • Cerebral Ventricles
  • Cerebrospinal Fluid
  • Cerebrovascular Circulation
  • Cross-Sectional Studies
  • Female
  • Hemodynamics
  • Humans
  • Magnetic Resonance Imaging
  • Male
  • Middle Aged

Keywords

  • Aging
  • Arterial cerebral blood flow
  • CSF flow
  • PC-MRI
  • Pulsatility
  • Venous cerebral blood flow


Age-specific health-related quality of life in disease-free long-term prostate cancer survivors versus male population controls-results from a population-based study.


MeSH Terms

  • Adult
  • Age Factors
  • Aged
  • Aging
  • Cancer Survivors
  • Case-Control Studies
  • Disease-Free Survival
  • Germany
  • Humans
  • Male
  • Middle Aged
  • Prostatic Neoplasms
  • Quality of Life
  • Surveys and Questionnaires
  • Young Adult

Keywords

  • Health-related quality of life
  • Long-term survivor
  • Population-based
  • Prostate cancer


Cross-Linked Polyphenol-Based Drug Nano-Self-Assemblies Engineered to Blockade Prostate Cancer Senescence.


MeSH Terms

  • Animals
  • Antineoplastic Agents
  • Apoptosis
  • Cell Line, Tumor
  • Cellular Senescence
  • Docetaxel
  • Forkhead Box Protein O1
  • Humans
  • Male
  • Mice
  • Mice, Nude
  • Nanostructures
  • Polyphenols
  • Prostatic Neoplasms
  • Receptor, Transforming Growth Factor-beta Type I
  • Signal Transduction
  • Tannins
  • Transplantation, Heterologous

Keywords

  • DSAs
  • apoptosis
  • docetaxel
  • nanoassemblies
  • prostate cancer
  • senescence


An Immersive Virtual Reality Platform for Assessing Spatial Navigation Memory in Predementia Screening: Feasibility and Usability Study.


Keywords

  • cognition
  • dementia
  • healthy aging
  • memory
  • virtual reality

PCNA[править]

Impairment of Pol β-related DNA Base-excision Repair Leads to Ovarian Aging in Mice.


Keywords

  • BER
  • Pol β
  • menopause
  • oocytes
  • ovarian aging


[Heat shock protein 90 (HSP90) in age-dependent changes in the number of fibroblasts in human skin.]


MeSH Terms

  • Adolescent
  • Adult
  • Aging
  • Child
  • Child, Preschool
  • Dermis
  • Female
  • Fibroblasts
  • HSP90 Heat-Shock Proteins
  • Humans
  • Infant
  • Infant, Newborn
  • Middle Aged
  • Pregnancy
  • Young Adult

Keywords

  • HSP90
  • PCNA
  • aging
  • fibroblasts
  • skin


A Higher Frequency Administration of the Nontoxic Cycloartane-Type Triterpene Argentatin A Improved Its Anti-Tumor Activity.


Keywords

  • Argentatin A
  • PCNA
  • antiproliferative
  • antitumor
  • apoptosis
  • cell senescence
  • colon cancer
  • xenografts


[Mechanosensitive protein of Hippo regulatory pathway - transcription coactivator with PZD-binding motif (TAZ) in human skin during aging.]


MeSH Terms

  • Adolescent
  • Adult
  • Aged
  • Aged, 80 and over
  • Aging
  • Child
  • Child, Preschool
  • Dermis
  • Female
  • Fibroblasts
  • Humans
  • Infant
  • Infant, Newborn
  • Middle Aged
  • Pregnancy
  • Protein-Serine-Threonine Kinases
  • Skin Aging
  • Trans-Activators
  • Young Adult

Keywords

  • CD31
  • PCNA
  • TAZ
  • aging
  • blood vessels
  • fibroblasts
  • skin


[Mechanosensitive Yes-associated protein in human skin during aging.]


MeSH Terms

  • Adaptor Proteins, Signal Transducing
  • Adult
  • Aged
  • Aged, 80 and over
  • Aging
  • Dermis
  • Endothelial Cells
  • Female
  • Fibroblasts
  • Humans
  • Middle Aged
  • Pregnancy
  • Skin Aging
  • Transcription Factors

Keywords

  • CD31
  • PCNA
  • YAP
  • aging
  • blood vessels
  • fibroblasts
  • skin


[Role of mechanosensitive protein Piezo1 in human age-dependent changes in the number of fibroblasts and blood vessels in human skin.]


MeSH Terms

  • Adolescent
  • Adult
  • Aged
  • Aged, 80 and over
  • Blood Vessels
  • Child
  • Child, Preschool
  • Dermis
  • Female
  • Fibroblasts
  • Humans
  • Infant
  • Ion Channels
  • Male
  • Middle Aged
  • Platelet Endothelial Cell Adhesion Molecule-1
  • Pregnancy
  • Proliferating Cell Nuclear Antigen
  • Skin Aging

Keywords

  • CD31
  • PCNA
  • Piezo1
  • aging
  • blood vessels
  • fibroblasts
  • skin

PCSK9[править]

Lipoprotein removal mechanisms and aging: implications for the cardiovascular health of the elderly.


MeSH Terms

  • Aged
  • Aged, 80 and over
  • Aging
  • Apolipoproteins B
  • Atherosclerosis
  • Cardiovascular Diseases
  • Cardiovascular System
  • Cholesterol
  • Humans
  • Lipid Metabolism
  • Lipoproteins
  • Lipoproteins, LDL
  • Risk Factors


The role of proprotein convertase subtilisin-kexin type 9 (PCSK9) in the vascular aging process - is there a link?


Keywords

  • PCSK9
  • atherosclerosis
  • cholesterol
  • inflammation
  • vascular aging

PDCD4[править]

Petal abscission in roses is associated with the activation of a truncated version of the animal PDCD4 homologue, RbPCD1.


MeSH Terms

  • Amino Acid Sequence
  • Arabidopsis
  • Gene Expression Regulation, Plant
  • Plant Proteins
  • Plants, Genetically Modified
  • Programmed Cell Death 1 Receptor
  • Rosa
  • Sequence Alignment
  • Transcription Factors

Keywords

  • Ethylene
  • Heat shock
  • Inflorescence
  • MA3 domain
  • PDCD4
  • Repression
  • Senescence

PDE2A[править]

TAK-915, a phosphodiesterase 2A inhibitor, ameliorates the cognitive impairment associated with aging in rodent models.


MeSH Terms

  • Aging
  • Animals
  • Brain
  • Cognition
  • Cognition Disorders
  • Cognitive Dysfunction
  • Cyclic AMP
  • Cyclic GMP
  • Cyclic Nucleotide Phosphodiesterases, Type 2
  • Male
  • Memory Disorders
  • Memory, Episodic
  • Phosphodiesterase Inhibitors
  • Pyrazines
  • Pyridines
  • Rats
  • Rats, Inbred F344
  • Rats, Long-Evans
  • Rats, Sprague-Dawley

Keywords

  • Aging
  • Cognition
  • PDE2A
  • TAK-915

PDE4D[править]

Phosphodiesterase PDE4D Is Decreased in Frontal Cortex of Aged Rats and Positively Correlated With Working Memory Performance and Inversely Correlated With PKA Phosphorylation of Tau.


Keywords

  • Alzheimer’s disease
  • PDE4D
  • aging
  • tau
  • working memory

PDE5A[править]

Repurposing erectile dysfunction drugs tadalafil and vardenafil to increase bone mass.


MeSH Terms

  • Aging
  • Animals
  • Bone Density
  • Bone and Bones
  • Brain
  • Cell Differentiation
  • Cyclic Nucleotide Phosphodiesterases, Type 5
  • Drug Repositioning
  • Erectile Dysfunction
  • Humans
  • Male
  • Mice
  • Middle Aged
  • Models, Animal
  • Models, Molecular
  • Neurons
  • Osteoblasts
  • Osteoclasts
  • Osteogenesis
  • Osteoporosis
  • Osteoporotic Fractures
  • Phosphodiesterase 5 Inhibitors
  • Primary Cell Culture
  • Tadalafil
  • Vardenafil Dihydrochloride

Keywords

  • PDE5 inhibitor
  • computational modeling
  • cyclic GMP
  • osteoporosis
  • resorption

PDK1[править]

Inhibition of 3-phosphoinositide-dependent protein kinase 1 (PDK1) can revert cellular senescence in human dermal fibroblasts.


Keywords

  • PDK1
  • cellular senescence
  • network modeling
  • skin aging
  • systems biology


The Impact of the PI3K/Akt Signaling Pathway in Anxiety and Working Memory in Young and Middle-Aged PDK1 K465E Knock-In Mice.


Keywords

  • PI3K/Akt
  • RDoC
  • aging
  • animal model
  • anxiety
  • cognition
  • fine tuning
  • signaling pathway

PER1[править]

Quercetin, caffeic acid and resveratrol regulate circadian clock genes and aging-related genes in young and old human lung fibroblast cells.


MeSH Terms

  • ARNTL Transcription Factors
  • Age Factors
  • Aging
  • CLOCK Proteins
  • Caffeic Acids
  • Cell Line
  • Circadian Clocks
  • Circadian Rhythm
  • Fibroblasts
  • Humans
  • NF-E2-Related Factor 2
  • Polyphenols
  • Quercetin
  • Receptors, Glucocorticoid
  • Resveratrol
  • Sirtuin 1

Keywords

  • Caffeic acid
  • Circadian clock genes
  • NR1D1
  • NRF2
  • Quercetin
  • Resveratrol

PER2[править]

NAD Controls Circadian Reprogramming through PER2 Nuclear Translocation to Counter Aging.


MeSH Terms

  • ARNTL Transcription Factors
  • Age Factors
  • Aging
  • Animals
  • CLOCK Proteins
  • Circadian Clocks
  • Circadian Rhythm
  • Cytokines
  • Female
  • HEK293 Cells
  • Humans
  • Male
  • Mice
  • Mice, Inbred C57BL
  • NAD
  • Period Circadian Proteins
  • Sirtuin 1
  • Sirtuins

Keywords

  • NAD(+)
  • SIRT1
  • aging
  • circadian
  • clock
  • heat shock factor 1
  • liver
  • nicotinamide mononucleotide
  • nicotinamide riboside
  • transcriptomics

PEX19[править]

A genome-wide screen identifies genes that suppress the accumulation of spontaneous mutations in young and aged yeast cells.


MeSH Terms

  • Amino Acid Transport Systems, Basic
  • Cellular Senescence
  • DNA Replication
  • Flap Endonucleases
  • Gene Ontology
  • Genetic Techniques
  • Genomic Instability
  • Membrane Proteins
  • Mutagenesis
  • Mutation
  • Mutation Accumulation
  • Mutation Rate
  • Nuclear Pore Complex Proteins
  • Saccharomyces cerevisiae
  • Saccharomyces cerevisiae Proteins
  • Single-Strand Specific DNA and RNA Endonucleases

Keywords

  • genome stability
  • high-throughput screen
  • mutagenesis
  • mutation rate
  • replicative aging
  • yeast

PEX5[править]

Aging lowers PEX5 levels in cortical neurons in male and female mouse brains.


Keywords

  • Aging brain
  • PEX5
  • Peroxisomal protein

PFAS[править]

Associations between serum concentrations of perfluoroalkyl substances and DNA methylation in women exposed through drinking water: A pilot study in Ronneby, Sweden.


Keywords

  • EPIC chip
  • Environmental pollutant
  • Epigenetic aging
  • Epigenetics
  • PFAS
  • Perfluoroalkyl substance


Perfluorinated alkyl substances impede growth, reproduction, lipid metabolism and lifespan in Daphnia magna.


MeSH Terms

  • Alkanesulfonic Acids
  • Animals
  • Caprylates
  • Daphnia
  • Fatty Acids
  • Fluorocarbons
  • Humans
  • Lipid Metabolism
  • Longevity
  • Reproduction

Keywords

  • Fatty acid
  • Fecundity
  • Gene expression
  • PFAS toxicity
  • Perfluorooctane sulfonate (PFOS)
  • Perfluorooctanoic acid (PFOA)


The effect of weathering on per- and polyfluoroalkyl substances (PFASs) from durable water repellent (DWR) clothing.


MeSH Terms

  • Acrylates
  • Alcohols
  • Clothing
  • Environmental Monitoring
  • Fluorocarbon Polymers
  • Fluorocarbons
  • Humidity
  • Models, Chemical
  • Textiles
  • Water
  • Water Pollutants, Chemical
  • Weather

Keywords

  • Aging
  • Durable water repellency
  • Outdoor clothing
  • Per- and polyfluoroalkyl substances
  • Textile
  • Weathering

PGC[править]

The Aging Stress Response and Its Implication for AMD Pathogenesis.


Keywords

  • AMD
  • DNA damage response
  • PGC-1α
  • SIRT1
  • age-related macular degeneration
  • aging
  • autophagy
  • insulin/IGF-1
  • mitochondrial quality control
  • the aging stress response


Constitutive PGC-1α Overexpression in Skeletal Muscle Does Not Contribute to Exercise-Induced Neurogenesis.


Keywords

  • Aging
  • Hippocampal neurogenesis
  • Immunohistochemistry
  • PGC-1α
  • Transgenic mice
  • Voluntary running


Dysregulated Autophagy Mediates Sarcopenic Obesity and Its Complications via AMPK and PGC1α Signaling Pathways: Potential Involvement of Gut Dysbiosis as a Pathological Link.


Keywords

  • AMPK signaling pathway
  • PGC-1α signaling pathway
  • aging
  • autophagy
  • gut axis
  • inflammation
  • insulin resistance
  • sarcopenic obesity


Resemblance and differences in dietary restriction nephroprotective mechanisms in young and old rats.


Keywords

  • aging
  • caloric restriction
  • ischemia/reperfusion
  • kidney injury
  • mitochondria


Acute and chronic effects of resistance training on skeletal muscle markers of mitochondrial remodeling in older adults.


Keywords

  • aging
  • mitochondrial dynamics
  • mitochondrial function


PGC-1α-mediated regulation of mitochondrial function and physiological implications.


Keywords

  • aging
  • exercise metabolism
  • insulin resistance
  • mitochondrial metabolism
  • muscle metabolism
  • muscle physiology
  • métabolisme mitochondrial
  • métabolisme musculaire
  • métabolisme à l’effort
  • physiologie musculaire
  • résistance à l’insuline
  • vieillissement


Targeting Mitochondrial Network Architecture in Down Syndrome and Aging.


Keywords

  • Down syndrome
  • PGC-1α/PPARGC1A
  • aging
  • mTOR
  • mitochondrial dynamics
  • mitochondrial function
  • mitochondrial network


Colchicine treatment impairs skeletal muscle mitochondrial function and insulin sensitivity in an age-specific manner.


Keywords

  • ADP sensitivity
  • ROS
  • aging
  • autophagy


A novel dipeptide from potato protein hydrolysate augments the effects of exercise training against high-fat diet-induced damages in senescence-accelerated mouse-prone 8 by boosting pAMPK / SIRT1/ PGC-1α/ pFOXO3 pathway.


Keywords

  • alcalase
  • bioactive peptides
  • cardio-protection
  • hepato-protection
  • longevity


Mitochondrial nucleoid remodeling and biogenesis are regulated by the p53-p21 -PKCζ pathway in p16 -silenced cells.


Keywords

  • mitochondria
  • nucleoid remodeling
  • p16INK4a silence
  • p53-p21-PKCζ activation
  • senescence


[Metabolic Alteration in Aging Process: Metabolic Remodeling in White Adipose Tissue by Caloric Restriction].


MeSH Terms

  • Adipose Tissue, White
  • Aging
  • Animals
  • Caloric Restriction
  • Gene Expression
  • Humans
  • Longevity
  • Mice
  • Organelle Biogenesis
  • Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha
  • Sirtuin 3
  • Sterol Regulatory Element Binding Protein 1
  • Up-Regulation

Keywords

  • caloric restriction (CR)
  • fatty acid biosynthesis
  • mitochondria
  • white adipose tissue (WAT)


Kynurenine aminotransferase isoforms display fiber-type specific expression in young and old human skeletal muscle.


Keywords

  • Aging
  • Kynurenine aminotransferases
  • Mitochondria
  • Muscle fiber-type
  • Skeletal muscle


Ubiquinol-10 delays postovulatory oocyte aging by improving mitochondrial renewal in pigs.


Keywords

  • mitochondria
  • oxidative stress
  • pig
  • postovulatory aging
  • ubiquinol-10


Mitochondrial oxidative capacity and NAD biosynthesis are reduced in human sarcopenia across ethnicities.


MeSH Terms

  • Aged
  • Aged, 80 and over
  • Aging
  • Biopsy
  • Case-Control Studies
  • Energy Metabolism
  • Humans
  • Jamaica
  • Male
  • Middle Aged
  • Mitochondria
  • Muscle, Skeletal
  • NAD
  • Oxidation-Reduction
  • Oxidative Phosphorylation
  • Oxidative Stress
  • Proteostasis
  • Sarcopenia
  • Singapore
  • United Kingdom


MicroRNA-34a (miR-34a) Mediates Retinal Endothelial Cell Premature Senescence through Mitochondrial Dysfunction and Loss of Antioxidant Activities.


Keywords

  • diabetic retinopathy
  • miR-34a
  • mitochondrial dysfunction
  • vascular senescence


Constitutive PGC-1α overexpression in skeletal muscle does not protect from age-dependent decline in neurogenesis.


MeSH Terms

  • Aging
  • Animals
  • Blood Proteins
  • Cytokines
  • Female
  • Hippocampus
  • Male
  • Mice, Inbred C57BL
  • Mice, Transgenic
  • Muscle, Skeletal
  • Neurogenesis
  • Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha
  • Reproducibility of Results

PGK2[править]

Arsenic influences spermatogenesis by disorganizing the elongation of spermatids in adult male mice.


MeSH Terms

  • Aging
  • Animals
  • Arsenic
  • Cell Cycle Proteins
  • DEAD-box RNA Helicases
  • Gene Expression Profiling
  • Male
  • Mice
  • RNA, Messenger
  • Spermatids
  • Spermatogenesis
  • Spermatozoa

Keywords

  • Arsenic
  • Elongation of spermatids
  • Male reproduction
  • Spermatogenesis

PGLS[править]

547 transcriptomes from 44 brain areas reveal features of the aging brain in non-human primates.


MeSH Terms

  • Aging
  • Animals
  • Brain
  • Carboxylic Ester Hydrolases
  • Macaca mulatta
  • Male
  • Mice
  • Transcriptome

Keywords

  • Brain aging
  • Multiple brain regions
  • PGLS
  • Rhesus macaques
  • Transcriptome

PIEZO1[править]

Niche stiffness underlies the ageing of central nervous system progenitor cells.


MeSH Terms

  • Adult Stem Cells
  • Aging
  • Animals
  • Animals, Newborn
  • Cell Count
  • Central Nervous System
  • Extracellular Matrix
  • Female
  • Humans
  • Membrane Proteins
  • Multipotent Stem Cells
  • Oligodendroglia
  • Rats
  • Stem Cell Niche

PINK1[править]

Spermidine inhibits neurodegeneration and delays aging via the PINK1-PDR1-dependent mitophagy pathway in [i]C. elegans[/i].


Keywords

  • aging
  • caenorhabditis elegans
  • mitophagy
  • neurodegenerative diseases
  • spermidine


Female mice are resilient to age-related decline of substantia nigra dopamine neuron firing parameters.


Keywords

  • Aging
  • Dopamine
  • Electrophysiology
  • Firing
  • Mouse
  • Substantia nigra


Attenuation of epigenetic regulator SMARCA4 and ERK-ETS signaling suppresses aging-related dopaminergic degeneration.


Keywords

Drosophila

  • MAPK-ERK-ETS signaling
  • Parkinson's disease
  • SMARCA4/Brahma
  • aging
  • neurodegeneration


SIRT1 alleviates high-magnitude compression-induced senescence in nucleus pulposus cells via PINK1-dependent mitophagy.


Keywords

  • SIRT1
  • compression
  • mitophagy
  • nucleus pulposus
  • senescence


Synergistic action of propolis with levodopa in the management of Parkinsonism in Drosophila melanogaster.


Keywords

  • Drosophila melanogaster
  • Levodopa induced dyskinesia
  • PINK1B9
  • Parkinsonism
  • Parkinson’s disease
  • aging
  • antioxidant activity
  • catalase
  • climbing index
  • lifespan
  • oxidative stress
  • propolis


Compression-induced senescence of nucleus pulposus cells by promoting mitophagy activation via the PINK1/PARKIN pathway.


Keywords

  • PARKIN pathway
  • PINK1
  • compression
  • intervertebral disc
  • mitophagy
  • senescence


Doxorubicin-induced normal breast epithelial cellular aging and its related breast cancer growth through mitochondrial autophagy and oxidative stress mitigated by ginsenoside Rh2.


MeSH Terms

  • Autophagy
  • Breast Neoplasms
  • Cell Culture Techniques
  • Cell Line, Tumor
  • Doxorubicin
  • Drugs, Chinese Herbal
  • Female
  • Ginsenosides
  • Humans
  • Mitochondria
  • Oxidative Stress

Keywords

  • ROS
  • cancer growth
  • cellular senescence
  • chemotherapy
  • ginsenoside Rh2
  • mitophagy


Mitochondrial DNA heteroplasmy rises in substantial nigra of aged PINK1 KO mice.


MeSH Terms

  • Aging
  • Animals
  • Brain
  • DNA Copy Number Variations
  • DNA, Mitochondrial
  • Gene Frequency
  • Mice, Knockout
  • Mutation Rate
  • Protein Kinases
  • Substantia Nigra

Keywords

  • PINK1
  • Parkin
  • Parkinson’s disease
  • mtDNA heteroplasmy

PIP[править]

Potentially inappropriate prescriptions according to explicit and implicit criteria in patients with multimorbidity and polypharmacy. MULTIPAP: A cross-sectional study.


MeSH Terms

  • Aged
  • Cross-Sectional Studies
  • Female
  • Geriatrics
  • Humans
  • Inappropriate Prescribing
  • Independent Living
  • Male
  • Multimorbidity
  • Polypharmacy
  • Potentially Inappropriate Medication List
  • Prevalence
  • Primary Health Care
  • Risk
  • Spain


Quality of prescribing predicts hospitalisation in octogenarians: life and living in advanced age: a cohort study in New Zealand (LiLACS NZ).


MeSH Terms

  • Aged
  • Aged, 80 and over
  • Aging
  • Cohort Studies
  • Drug Prescriptions
  • Female
  • Follow-Up Studies
  • Forecasting
  • Hospitalization
  • Humans
  • Inappropriate Prescribing
  • Longitudinal Studies
  • Male
  • New Zealand
  • Patient Discharge
  • Potentially Inappropriate Medication List

Keywords

  • Appropriate prescribing
  • Ethnicity
  • Longitudinal study
  • Older people

PLIN2[править]

Cardiac overexpression of perilipin 2 induces atrial steatosis, connexin 43 remodeling, and atrial fibrillation in aged mice.


MeSH Terms

  • Animals
  • Atrial Fibrillation
  • Connexin 43
  • Gene Knock-In Techniques
  • Heart Atria
  • Isolated Heart Preparation
  • Lipid Droplets
  • Mice
  • Mice, Transgenic
  • Microscopy, Electron
  • Myocytes, Cardiac
  • Perilipin-2
  • Sterol Esterase
  • Triglycerides
  • Voltage-Sensitive Dye Imaging

Keywords

  • aging
  • cardiac steatosis
  • gap junction
  • lipid droplets
  • lipotoxic arrhythmia

PLK4[править]

A novel lncRNA PLK4 up-regulated by talazoparib represses hepatocellular carcinoma progression by promoting YAP-mediated cell senescence.


Keywords

  • Yes-associated protein
  • cellular senescence
  • hepatocellular carcinoma
  • polo-like kinase 4 associated lncRNA
  • talazoparib


Differential expression of AURKA/PLK4 in quiescence and senescence of osteosarcoma U2OS cells.


Keywords

  • AURKA
  • Osteosarcoma
  • PLK4
  • quiescence
  • senescence

PLN[править]

An analysis of the costs of treating aged patients in a large clinical hospital in Poland under the pressure of recent demographic trends.


Keywords

  • Polish health care system
  • ageing society
  • gerontology
  • healthcare
  • hospital costs
  • length and cost of hospitalization

PML[править]

Progressive multifocal leukoencephalopathy in dimethyl fumarate-treated multiple sclerosis patients.


Keywords

  • Multiple sclerosis
  • PML
  • fumarate
  • immunosenescence
  • lymphopenia


PML2-mediated thread-like nuclear bodies mark late senescence in Hutchinson-Gilford progeria syndrome.


Keywords

  • HGPS
  • PML2
  • senescence
  • thread-like PML NBs

PNN[править]

Hyaluronan degradation and release of a hyaluronan-aggrecan complex from perineuronal nets in the aged mouse brain.


Keywords

  • Brain aging
  • Chondroitin sulfate proteoglycan
  • Extracellular matrix
  • Hyaluronan
  • Perineuronal net

PNP[править]

Temporal Discrimination Thresholds and Proprioceptive Performance: Impact of Age and Nerve Conduction.


Keywords

  • TDMT
  • aging
  • kinesthesia
  • pointing task
  • position estimation
  • somatosensory temporal discrimination
  • temporal discrimination threshold

POLL[править]

Temporal trends in loss of life expectancy after a cancer diagnosis among the Australian population.


MeSH Terms

  • Aged
  • Aged, 80 and over
  • Australia
  • Cancer Survivors
  • Cohort Studies
  • Female
  • Humans
  • Life Expectancy
  • Male
  • Middle Aged
  • Neoplasms

Keywords

  • Australia
  • Cancer
  • Life expectancy
  • Survival
  • Temporal

POLR3A[править]

Nucleolar disruption, activation of P53 and premature senescence in POLR3A-mutated Wiedemann-Rautenstrauch syndrome fibroblasts.


Keywords

  • Cell senescence
  • DNA damage
  • Nucleolus
  • Nucleus
  • RNA polymerase III subunit A (POLR3A)
  • Wiedemann-Rautenstrauch syndrome

POMC[править]

Gpr17 deficiency in POMC neurons ameliorates the metabolic derangements caused by long-term high-fat diet feeding.


MeSH Terms

  • Aging
  • Animals
  • Body Weight
  • Brain
  • Diet, High-Fat
  • Energy Metabolism
  • Female
  • Homeostasis
  • Insulin Resistance
  • Liver
  • Male
  • Mice
  • Mice, Knockout
  • Motor Activity
  • Nerve Tissue Proteins
  • Neurons
  • Pro-Opiomelanocortin
  • Receptors, G-Protein-Coupled
  • Sex Factors

POR[править]

The Ventricular System Enlarges Abnormally in the Seventies, Earlier in Men, and First in the Frontal Horn: A Study Based on More Than 3,000 Scans.


Keywords

  • Evans’ index
  • aging
  • brain
  • enlargement
  • hydrocephalus
  • normal pressure
  • ventricular system

POT1[править]

MiR-185 targets POT1 to induce telomere dysfunction and cellular senescence.


Keywords

  • aging
  • cellular senescence
  • miR-185
  • protection of telomere 1
  • telomere dysfunction


Seryl tRNA synthetase cooperates with POT1 to regulate telomere length and cellular senescence.


Keywords

  • Cancer genomics
  • Senescence

POU5F1[править]

Cell quality evaluation with gene expression analysis of spheroids (3D) and adherent (2D) adipose stem cells.


Keywords

  • ALDH family
  • Adipose stem cells
  • Aging
  • Shelterin complex
  • Spheroid
  • Telomere length

PPID[править]

Relationships of inflamm-aging with circulating nutrient levels, body composition, age, and pituitary pars intermedia dysfunction in a senior horse population.


MeSH Terms

  • Aging
  • Animals
  • Body Composition
  • Cytokines
  • Female
  • Folic Acid
  • Horse Diseases
  • Horses
  • Inflammation
  • Male
  • Nutrients
  • Pituitary Diseases
  • Pituitary Gland, Intermediate

Keywords

  • Horse
  • Inflamm-aging
  • Muscle
  • Nutrition
  • Pituitary pars intermedia dysfunction
  • Senior

PRDM8[править]

PRDM8 reveals aberrant DNA methylation in aging syndromes and is relevant for hematopoietic and neuronal differentiation.


Keywords

  • Aging
  • Aplastic anemia
  • DNA methylation
  • Dyskeratosis congenita
  • Epigenetic clock
  • Hematopoietic differentiation
  • Neuronal differentiation
  • PRDM8
  • Telomere
  • iPSC

PRDX1[править]

Active vitamin D supplementation alleviates initiation and progression of nonalcoholic fatty liver disease by repressing the p53 pathway.


MeSH Terms

  • Animals
  • Apoptosis
  • Cellular Senescence
  • Diet, High-Fat
  • Dietary Supplements
  • Fas Ligand Protein
  • Hepatocytes
  • Metabolic Networks and Pathways
  • Mice, Knockout
  • Non-alcoholic Fatty Liver Disease
  • Oxidative Stress
  • Proteins
  • Steroid Hydroxylases
  • Tumor Suppressor Protein p53
  • Vitamin D
  • fas Receptor

Keywords

  • Active vitamin D
  • Apoptosis
  • Nonalcoholic fatty liver disease
  • Oxidative stress
  • Senescence
  • p53 pathway

PRDX3[править]

Proteomic analyses reveal that ginsenoside Rg3([i]S[/i]) partially reverses cellular senescence in human dermal fibroblasts by inducing peroxiredoxin.


Keywords

  • Ginsenoside Rg3(S)
  • Human dermal fibroblast
  • Label-free quantitative proteomics
  • Restoration
  • Senescence

PRDX6[править]

Dentate Gyrus Peroxiredoxin 6 Levels Discriminate Aged Unimpaired From Impaired Rats in a Spatial Memory Task.


Keywords

  • PRDX6
  • aging
  • dentate gyrus
  • hippocampus
  • hole-board
  • peroxiredoxin
  • proteomics
  • spatial memory

PRKDC[править]

DNA-PKcs modulates progenitor cell proliferation and fibroblast senescence in idiopathic pulmonary fibrosis.


MeSH Terms

  • Animals
  • Cell Line
  • Cell Proliferation
  • Cellular Senescence
  • Chromones
  • DNA Damage
  • DNA Repair
  • DNA-Activated Protein Kinase
  • DNA-Binding Proteins
  • Female
  • Fibroblasts
  • Humans
  • Idiopathic Pulmonary Fibrosis
  • Lung
  • Mesenchymal Stem Cells
  • Mice
  • Mice, SCID
  • Morpholines

Keywords

  • DNA-PKcs
  • IPF
  • Mesenchymal progenitor cells
  • Senescence

PRL[править]

Mechanism of PRL2 phosphatase-mediated PTEN degradation and tumorigenesis.


MeSH Terms

  • Animals
  • Carcinogenesis
  • Female
  • HEK293 Cells
  • Humans
  • Immediate-Early Proteins
  • Longevity
  • Male
  • Mice, Inbred C57BL
  • Mice, Knockout
  • Nedd4 Ubiquitin Protein Ligases
  • PTEN Phosphohydrolase
  • Protein Tyrosine Phosphatases
  • Proto-Oncogene Proteins c-akt
  • Ubiquitination

Keywords

  • NEDD4
  • PRL2
  • PTEN
  • protein tyrosine phosphatases
  • ubiquitination


Prolactin mitigates deficiencies of retinal function associated with aging.


MeSH Terms

  • Aging
  • Animals
  • Apoptosis
  • Electroretinography
  • Mice, Inbred C57BL
  • Nerve Growth Factors
  • Neuroglia
  • Prolactin
  • Retina
  • Retinal Degeneration

Keywords

  • Aging
  • Apoptosis
  • Glia activation
  • Hormone
  • Mesotopic and photopic electroretinogram
  • Retina


A Spontaneous Aggressive ERα+ Mammary Tumor Model Is Driven by Kras Activation.


MeSH Terms

  • Aging
  • Animals
  • Carcinogenesis
  • Datasets as Topic
  • Estrogen Receptor alpha
  • Female
  • Gene Expression Profiling
  • Humans
  • Mammary Neoplasms, Experimental
  • Mice
  • Prolactin
  • Proto-Oncogene Proteins p21(ras)
  • Rats
  • Signal Transduction
  • Transgenes

Keywords

  • ER+ breast cancer
  • Ras mutations
  • breast cancer
  • genomic analyses
  • mouse models
  • prolactin

PRNP[править]

Spontaneous generation of prions and transmissible PrP amyloid in a humanised transgenic mouse model of A117V GSS.


MeSH Terms

  • Adult
  • Aging
  • Amyloid
  • Animals
  • Brain
  • Codon
  • Heterozygote
  • Homozygote
  • Humans
  • Mice, Transgenic
  • Middle Aged
  • Prions

PROC[править]

Does midlife aging impact women's sleep duration, continuity, and timing?: A longitudinal analysis from the Study of Women's Health Across the Nation.


Keywords

  • actigraphy
  • aging
  • sleep duration
  • sleep in women
  • sleep quality

PSD[править]

Quantitative Immunoblotting Analyses Reveal that the Abundance of Actin, Tubulin, Synaptophysin and EEA1 Proteins is Altered in the Brains of Aged Mice.


Keywords

  • aging
  • brain
  • cortex
  • glutamate receptor
  • synapse
  • vesicle


Exercise Attenuates Brain Aging by Rescuing Down-Regulated Wnt/β-Catenin Signaling in Aged Rats.


Keywords

  • DKK-1
  • Wnt
  • brain aging
  • exercise
  • β-catenin


Concurrent nicotine exposure to prenatal alcohol consumption alters the hippocampal and cortical neurotoxicity.


Keywords

  • Aging
  • Mitochondrial function
  • Neuroscience
  • Oxidative stress

PSEN2[править]

Accelerated brain aging towards transcriptional inversion in a zebrafish model of the K115fs mutation of human PSEN2.


MeSH Terms

  • Aging
  • Alternative Splicing
  • Alzheimer Disease
  • Animals
  • Animals, Genetically Modified
  • Brain
  • Datasets as Topic
  • Disease Models, Animal
  • Down-Regulation
  • Female
  • Frameshift Mutation
  • Gene Editing
  • Gene Regulatory Networks
  • Heterozygote
  • Humans
  • Microglia
  • Presenilin-1
  • Presenilin-2
  • Protein Isoforms
  • Proteomics
  • RNA-Seq
  • Up-Regulation
  • Zebrafish
  • Zebrafish Proteins


Loss of presenilin 2 age-dependently alters susceptibility to acute seizures and kindling acquisition.


Keywords

  • Aging
  • Alzheimer's
  • Carbamazepine
  • Corneal kindling
  • Diazepam
  • Epilepsy
  • Lamotrigine
  • Levetiracetam
  • Presenilin
  • Seizures
  • Valproic acid

PSMD11[править]

The effect and mechanism of 19S proteasome PSMD11/Rpn6 subunit in D-Galactose induced mimetic aging models.


Keywords

  • Age-related hearing loss
  • Aging
  • D-galactose
  • PSMD11
  • Proteasome

PSMD14[править]

Upregulation of deubiquitinase PSMD14 in lung adenocarcinoma (LUAD) and its prognostic significance.


Keywords

  • PMSD14
  • apoptosis
  • deubiquitinating enzyme
  • lung adenocarcinoma
  • prognosis
  • senescence

PTEN[править]

Senescence Reprogramming by TIMP1 Deficiency Promotes Prostate Cancer Metastasis.


Keywords

  • FGF1
  • GDF-15
  • MMPs
  • PTEN
  • TIMP1
  • docetaxel
  • prostate cancer metastasis
  • senescence
  • senescence-associated secretory phenotype (SASP)
  • senolytic therapy


Alterations in Mitochondrial Dynamic-related Genes in the Peripheral Blood of Alzheimer's Disease Patients.


Keywords

  • Alzheimer's disease
  • DRP1
  • FIS1
  • aging
  • mitochondrial dynamics
  • mitophagy


Human ESC-sEVs alleviate age-related bone loss by rejuvenating senescent bone marrow-derived mesenchymal stem cells.


Keywords

  • Extracellular vesicle
  • bone loss
  • bone marrow MSCs
  • cellular senescence
  • embryonic stem cells


The precursor of PI(3,4,5)P alleviates aging by activating daf-18(Pten) and independent of daf-16.


MeSH Terms

  • Aging
  • Animals
  • Animals, Genetically Modified
  • Caenorhabditis elegans
  • Caenorhabditis elegans Proteins
  • Cell Line, Tumor
  • Female
  • Forkhead Transcription Factors
  • Inositol
  • Locomotion
  • Longevity
  • Metabolic Networks and Pathways
  • Metabolomics
  • Mice
  • Mitophagy
  • Models, Animal
  • PTEN Phosphohydrolase
  • Phosphatidylinositol Phosphates
  • Protein Kinases
  • Protein-Serine-Threonine Kinases
  • RNA Interference
  • RNA-Seq


Quercetin alleviates kidney fibrosis by reducing renal tubular epithelial cell senescence through the SIRT1/PINK1/mitophagy axis.


MeSH Terms

  • Animals
  • Antioxidants
  • Cell Line
  • Cellular Senescence
  • Epithelium
  • Fibrosis
  • Flow Cytometry
  • Kidney
  • Kidney Tubules, Proximal
  • Mitophagy
  • Protein Kinases
  • Quercetin
  • Rats
  • Sirtuin 1

Keywords

  • Fibrosis
  • Mitochondria
  • Mitophagy
  • Quercetin
  • Senescence


Downregulation of PTEN mediates bleomycin-induced premature senescence in lung cancer cells by suppressing autophagy.


Keywords

  • PI3K/Akt/mTOR pathway
  • PTEN
  • autophagy
  • bleomycin
  • cancer cell
  • premature senescence


miR-155 inhibits mitophagy through suppression of BAG5, a partner protein of PINK1.


MeSH Terms

  • Adaptor Proteins, Signal Transducing
  • Aging
  • Animals
  • Cell Line
  • Cells, Cultured
  • Down-Regulation
  • Humans
  • Male
  • Mesenchymal Stem Cells
  • Mice, Inbred C57BL
  • MicroRNAs
  • Mitophagy
  • Protein Interaction Maps
  • Protein Kinases
  • Up-Regulation

Keywords

  • Aging
  • Bone marrow MSCs
  • Mitophagy
  • miR-155


Environmental Exposures and Asthma Development: Autophagy, Mitophagy, and Cellular Senescence.


MeSH Terms

  • Airway Remodeling
  • Asthma
  • Autophagy
  • Cellular Senescence
  • Disease Susceptibility
  • Environmental Exposure
  • Humans
  • Mitophagy
  • Oxidative Stress
  • Respiratory Mucosa

Keywords

  • asthma
  • autophagy
  • mitophagy
  • oxidative stress
  • senescence


PTEN loss regulates alveolar epithelial cell senescence in pulmonary fibrosis depending on Akt activation.


MeSH Terms

  • Aging
  • Cellular Senescence
  • Epithelial Cells
  • Humans
  • Idiopathic Pulmonary Fibrosis
  • PTEN Phosphohydrolase
  • Proto-Oncogene Proteins c-akt
  • Pulmonary Alveoli
  • Respiratory Mucosa

Keywords

  • aging
  • cellular senescence
  • phosphatase and tension homolog deleted on chromosome ten
  • protein kinase B
  • pulmonary fibrosis

PTH[править]

Vitamin D Receptor Polymorphisms in Sex-Frailty Paradox.


Keywords

  • aging
  • frailty
  • vitamin D
  • vitamin D receptor


Parathyroid hormone ameliorates temporomandibular joint osteoarthritic-like changes related to age.


MeSH Terms

  • Aging
  • Animals
  • Calcium-Regulating Hormones and Agents
  • Cells, Cultured
  • Disease Models, Animal
  • Male
  • Mice
  • Mice, Inbred C57BL
  • Osteoarthritis
  • Osteogenesis
  • Parathyroid Hormone
  • Temporomandibular Joint

Keywords

  • cellular senescence
  • cyclin-dependent kinase inhibitor P16INK4A
  • marrow mesenchymal stem cells
  • osteoarthritis
  • temporomandibular joint disorders

PTP4A3[править]

Transcriptional and Functional Changes of the Human Microvasculature during Physiological Aging and Alzheimer Disease.


Keywords

  • 3D microvascular network
  • blood-brain barrier
  • endothelium
  • human serum
  • vascular aging

PTPN11[править]

Fine mapping genetic variants associated with age at puberty and sow fertility using SowPro90 genotyping array.


Keywords 

         SowPro90
  • Bayes interval mapping
  • custom genotyping array
  • gilts
  • puberty
  • reproductive longevity

PTTG1[править]

[Down-regulated PTTG1 expression promotes the senescence of human prostate cancer LNCaP-AI].


MeSH Terms

  • Cell Line, Tumor
  • Cell Proliferation
  • Humans
  • Male
  • Prostatic Neoplasms, Castration-Resistant
  • RNA, Small Interfering
  • Securin
  • beta-Galactosidase

Keywords

  • LNCaP-AI cell


  • castration-resistant prostate cancer
  • cellular senescence
  • pituitary tumor-transforming gene-1
  • prostate cancer

PTX3[править]

Aerobic Training Down-Regulates Pentraxin 3 and Pentraxin 3/Toll-Like Receptor 4 Ratio, Irrespective of Oxidative Stress Response, in Elderly Subjects.


Keywords

  • aging
  • endurance training
  • exercise
  • inflammation
  • oxidative stress
  • pentraxin 3
  • toll-like receptor 4


Sex Differences in the Association Between Pentraxin 3 and Cognitive Decline: The Cardiovascular Health Study.


Keywords

  • Biomarkers
  • Cognitive aging
  • Inflammation
  • Sex differences

PUM1[править]

Identification of reference genes for RT-qPCR data normalisation in aging studies.


MeSH Terms

  • Aging
  • Algorithms
  • Gene Expression Profiling
  • Genes, Essential
  • Humans
  • Real-Time Polymerase Chain Reaction
  • Software

RACK1[править]

Invariable stoichiometry of ribosomal proteins in mouse brain tissues with aging.


MeSH Terms

  • Aging
  • Animals
  • Brain
  • Female
  • Gene Expression Regulation, Developmental
  • Male
  • Mice
  • Proteomics
  • Ribosomal Proteins

Keywords

  • aging
  • mass spectrometry
  • neuronal tissues
  • ribosome
  • translation

RAF1[править]

Circular [i]ANRIL[/i] isoforms switch from repressors to activators of [i]p15/CDKN2B[/i] expression during RAF1 oncogene-induced senescence.


Keywords

  • INK4 locus
  • Non-coding RNAs
  • Polycomb proteins
  • circular RNAs
  • gene expression regulation
  • oncogene-induced senescence

RAG1[править]

T cell senescence accelerates Angiotensin II-induced target organ damage.


Keywords

  • T cell
  • angiotensin II
  • cardiorenal dysfunction
  • senescence

RAG2[править]

Phosphate Transporter Profiles in Murine and Human Thymi Identify Thymocytes at Distinct Stages of Differentiation.


Keywords

  • aging
  • glucose transporters
  • human
  • metabolism
  • mice
  • phosphate transporters
  • thymus

RAN[править]

Rapid automatized naming (RAN): effects of aging on a predictor of reading skill.


Keywords

  • Aging
  • RAN
  • individual differences
  • naming
  • reading

RELB[править]

New control of the senescence barrier in breast cancer.


Keywords

  • CEBPB
  • Cellular senescence
  • PAK4
  • RELB
  • p21-activated kinase

REST[править]

[Brain and Neuronal Aging: Aged Brain Controls via Gene Expression Fidelity and Master Regulatory Factors].


MeSH Terms

  • Aged
  • Aged, 80 and over
  • Aging
  • Animals
  • Brain
  • Gene Expression
  • Gene Expression Regulation, Developmental
  • Humans
  • Neurodegenerative Diseases
  • Protein Biosynthesis
  • Repressor Proteins
  • Ribosomes

Keywords

  • aging
  • brain
  • gene expression
  • neurodegeneration
  • ribosome
  • translational fidelity


Effect of 9 - PAHSA on cognitive dysfunction in diabetic mice and its possible mechanism.


MeSH Terms

  • Aging
  • Animals
  • Behavior, Animal
  • Blood Glucose
  • Body Weight
  • Brain
  • Brain-Derived Neurotrophic Factor
  • Cognitive Dysfunction
  • Diabetes Mellitus, Experimental
  • Exploratory Behavior
  • Male
  • Memory Disorders
  • Mice
  • Palmitic Acid
  • Repressor Proteins
  • Social Behavior
  • Spatial Memory
  • Stearic Acids

Keywords

  • 9-PAHSA
  • BDNF
  • Diabetes mellitus
  • REST


Increased REST to Optimize Life Span?


MeSH Terms

  • Animals
  • Caenorhabditis elegans
  • Caenorhabditis elegans Proteins
  • Homeostasis
  • Longevity
  • Repressor Proteins
  • Signal Transduction

Keywords

  • life span
  • neuronal activity
  • neurotoxicity

RET[править]

Effects of resistance exercise training on redox homeostasis in older adults. A systematic review and meta-analysis.


Keywords

  • Aging
  • Antioxidants
  • Exercise
  • Oxidative stress
  • Resistance exercise training


Effects of an 8-week resistance training intervention on plantar flexor muscle quality and functional capacity in older women: A randomised controlled trial.


Keywords

  • Aging
  • Muscle echo intensity
  • Muscle quality
  • Physical function
  • Resistance training


Resistance exercise training promotes fiber type-specific myonuclear adaptations in older adults.


Keywords

  • aging
  • hypertrophy
  • myonuclear domain
  • skeletal muscle


Low skeletal muscle capillarization limits muscle adaptation to resistance exercise training in older adults.


MeSH Terms

  • Adaptation, Physiological
  • Aged
  • Capillaries
  • Citrate (si)-Synthase
  • Exercise
  • Female
  • Humans
  • Hypertrophy
  • Male
  • Muscle Fibers, Skeletal
  • Muscle Proteins
  • Muscle, Skeletal
  • Resistance Training
  • Sarcopenia
  • Ubiquitin-Protein Ligases

Keywords

  • Aging
  • Capillary
  • Fiber cross-sectional area
  • Muscle hypertrophy
  • Muscle protein synthesis

REV1[править]

REV1 inhibitor JH-RE-06 enhances tumor cell response to chemotherapy by triggering senescence hallmarks.


Keywords

  • Rev1
  • cell death
  • chemotherapy
  • senescence
  • translesion synthesis

RHEB[править]

The Rheb-TORC1 signaling axis functions as a developmental checkpoint.


MeSH Terms

  • Animals
  • Animals, Genetically Modified
  • Autophagy
  • CRISPR-Cas Systems
  • Caenorhabditis elegans
  • Caenorhabditis elegans Proteins
  • Life Cycle Stages
  • Longevity
  • Mechanistic Target of Rapamycin Complex 1
  • Phosphotransferases (Alcohol Group Acceptor)
  • RNA Interference
  • RNA, Small Interfering
  • Ras Homolog Enriched in Brain Protein
  • Signal Transduction

Keywords

  • MTOR
  • MTORC1
  • Ral
  • RalGAP
  • TSC
  • Tuberous sclerosis complex

RHO[править]

Conditional reprogramming: next generation cell culture.


Keywords

  • 3T3-J2 fibroblast
  • AACR, American Association for Cancer Research
  • ACC, adenoid cystic carcinoma
  • AR, androgen receptor
  • CFTR, cystic fibrosis transmembrane conductance regulators
  • CR, conditional reprogramming
  • CYPs, cytochrome P450 enzymes
  • Conditional reprogramming
  • DCIS, ductal carcinoma in situ
  • ECM, extracellular matrix
  • ESC, embryonic stem cell
  • HCMI, human cancer model initiatives
  • HGF, hepatocyte growth factor
  • HNE, human nasal epithelial
  • HPV, human papillomaviruses
  • ICD, intracellular domain
  • LECs, limbal epithelial cells
  • NCI, National Cancer Institute
  • NGFR, nerve growth factor receptor
  • NSCLC, non-small cell lung cancer
  • NSG, NOD/SCID/gamma
  • PDAC, pancreatic ductal adenocarcinoma
  • PDX, patient derived xenograft
  • PP2A, protein phosphatase 2A
  • RB, retinoblastoma-associated protein
  • ROCK
  • ROCK, Rho kinase
  • SV40, simian virus 40 large tumor antigen
  • Senescence
  • UVB, ultraviolet radiation b
  • Y-27632
  • dECM, decellularized extracellular matrix
  • hASC, human adipose stem cells
  • hTERT, human telomerase reverse transcriptase
  • iPSCs, induction of pluripotent stem cells
  • ΔNP63α, N-terminal truncated form of P63α


SARS-CoV-2 receptor ACE2 and TMPRSS2 are primarily expressed in bronchial transient secretory cells.


MeSH Terms

  • Adult
  • Aging
  • Angiotensin-Converting Enzyme 2
  • Bronchi
  • COVID-19
  • Cells, Cultured
  • Chronic Disease
  • Coronavirus Infections
  • Epithelial Cells
  • Female
  • Gene Expression
  • Gene Expression Profiling
  • Germany
  • Goblet Cells
  • Humans
  • Lung
  • Male
  • Middle Aged
  • Pandemics
  • Peptidyl-Dipeptidase A
  • Pneumonia, Viral
  • Reference Standards
  • Sequence Analysis, RNA
  • Serine Endopeptidases
  • Sex Characteristics
  • Single-Cell Analysis
  • Smoking
  • Tissue Banks

Keywords

FURIN

  • COVID-19
  • Human Cell Atlas
  • epithelial differentiation
  • respiratory tract

RICTOR[править]

Endothelial senescence-associated secretory phenotype (SASP) is regulated by Makorin-1 ubiquitin E3 ligase.


MeSH Terms

  • Cellular Senescence
  • Endothelial Cells
  • Human Umbilical Vein Endothelial Cells
  • Humans
  • MicroRNAs
  • Nerve Tissue Proteins
  • Phosphorylation
  • Protein Binding
  • Rapamycin-Insensitive Companion of mTOR Protein
  • Ribonucleoproteins
  • Telomeric Repeat Binding Protein 2
  • Ubiquitin-Protein Ligases

Keywords

  • Inflammation
  • MKRN1
  • Senescence
  • Senescence-associated secretory phenotype (SASP)
  • Telomeric repeat binding factor 2-interacting protein (TERF2IP)
  • p90RSK

RIF1[править]

53BP1 Enforces Distinct Pre- and Post-resection Blocks on Homologous Recombination.


MeSH Terms

  • Aging
  • Animals
  • BRCA1 Protein
  • DNA Breaks, Double-Stranded
  • DNA Damage
  • Genomic Instability
  • Homologous Recombination
  • Mice
  • Mutation
  • Poly(ADP-ribose) Polymerase Inhibitors
  • Rad51 Recombinase
  • Tumor Suppressor p53-Binding Protein 1
  • Ubiquitin-Protein Ligases

Keywords

  • 53BP1
  • BRCA1
  • PARPi
  • aging
  • cancer
  • homologous recombination
  • resection
  • shieldin

RIPK1[править]

Casein kinase 1G2 suppresses necroptosis-promoted testis aging by inhibiting receptor-interacting kinase 3.


Keywords

  • aging
  • cell biology
  • mouse
  • necroptosis
  • protein kinase
  • reproductivity
  • testis


Crucial role of the terminal complement complex in chondrocyte death and hypertrophy after cartilage trauma.


Keywords

  • Aurintricarboxylic acid
  • Cartilage trauma
  • Hypertrophy
  • Regulated cell death
  • Senescence
  • Terminal complement complex

RIPK3[править]

Metformin mediates cardioprotection against aging-induced ischemic necroptosis.


MeSH Terms

  • Aging
  • Animals
  • Autophagy
  • GTPase-Activating Proteins
  • Humans
  • Hypoglycemic Agents
  • Imidazoles
  • Indoles
  • Male
  • Metformin
  • Mice
  • Mice, Inbred C57BL
  • Mice, Knockout
  • Myocardium
  • Myocytes, Cardiac
  • Necroptosis
  • Protein Binding
  • RNA, Small Interfering
  • Receptor-Interacting Protein Serine-Threonine Kinases
  • Reperfusion Injury
  • Sequestosome-1 Protein

Keywords

  • aging
  • autophagy defect
  • cardioprotection
  • ischemia/reperfusion injury
  • metformin
  • myocardial necroptosis

RNF10[править]

Reduced RING finger protein 10 expression in macrophages is associated with aging-related inflammation.


Keywords

  • E3 ubiquitin ligase
  • RNF10
  • immunosenescence
  • inflammation
  • macrophages

RNF13[править]

The effects of environmental stressors on candidate aging associated genes.


Keywords

  • Aging
  • Candidate genes
  • Environmental factors
  • Epigenetic
  • Hypo/hyper methylated (methylation)

ROCK2[править]

Physical exercise increases ROCK activity in the skeletal muscle of middle-aged rats.


Keywords

  • Aging
  • Insulin resistance
  • Physical exercise
  • Rho-kinase (ROCK)

RPE[править]

Transcriptomic Profiling of Human Pluripotent Stem Cell-derived Retinal Pigment Epithelium over Time.


Keywords

  • Aging
  • Human embryonic stem cell
  • Human pluripotent stem cell
  • Retinal pigment epithelium
  • Single-cell RNA sequencing


Relationship between Oxygen Uptake, Heart Rate, and Perceived Effort in an Aquatic Incremental Test in Older Women.


Keywords

  • aging
  • cardiorespiratory
  • maximum test
  • rate of perceived exertion
  • water aerobics
  • water-based exercises


Photoreceptor Degeneration in Homozygous Male Per2 Mice During Aging.


Keywords

  • Per2luc
  • aging
  • circadian
  • mice
  • photoreceptors
  • retinal pigment epithelium


An In-Vitro Cell Model of Intracellular Protein Aggregation Provides Insights into RPE Stress Associated with Retinopathy.


Keywords

  • AMD
  • RPE
  • aging
  • autofluorescence
  • autophagy
  • diet
  • lysosomes
  • oxidized POS
  • proteolysis
  • retina


Short-Term Effect of Self-Selected Training Intensity on Ambulatory Blood Pressure in Hypertensive Older Women: A Randomized Controlled Trial.


Keywords

  • aging
  • exercise
  • hypertension


Correlation between brain volume and retinal photoreceptor outer segment volume in normal aging and neurodegenerative diseases.


MeSH Terms

  • Aged
  • Aging
  • Brain
  • Female
  • Humans
  • Linear Models
  • Magnetic Resonance Imaging
  • Male
  • Middle Aged
  • Multivariate Analysis
  • Neurodegenerative Diseases
  • Organ Size
  • Retinal Photoreceptor Cell Outer Segment
  • Retinal Pigment Epithelium
  • Tomography, Optical Coherence


Oxidative stress in the retina and retinal pigment epithelium (RPE): Role of aging, and DJ-1.


Keywords

  • Aging
  • DJ-1
  • Oxidative stress
  • Retina
  • Retinal pigment epithelium
  • Sodium iodate


Direct-Coupled Electroretinogram (DC-ERG) for Recording the Light-Evoked Electrical Responses of the Mouse Retinal Pigment Epithelium.


MeSH Terms

  • Aging
  • Animals
  • Electrophysiological Phenomena
  • Electroretinography
  • Light
  • Mice
  • Retinal Pigment Epithelium


High-density lipoproteins are a potential therapeutic target for age-related macular degeneration.


Keywords

  • age-related macular degeneration
  • aging
  • apolipoprotein
  • complement
  • complement factor H
  • glycosaminoglycan
  • heparan sulfate
  • heparan sulfate proteoglycans
  • high-density lipoprotein (HDL)
  • lipoprotein
  • oligosaccharide
  • retinal degeneration
  • retinal pigmented epithelium


MTOR-initiated metabolic switch and degeneration in the retinal pigment epithelium.


Keywords

  • AMD
  • Mtor
  • aging
  • lipid
  • metabolism


[i]Lactobacillus paracasei[/i] KW3110 Suppresses Inflammatory Stress-Induced Premature Cellular Senescence of Human Retinal Pigment Epithelium Cells and Reduces Ocular Disorders in Healthy Humans.


Keywords

  • cellular senescence
  • eye fatigue
  • inflammation
  • lactic acid bacteria
  • probiotics
  • retina


Retinal pigment epithelium transcriptome analysis in chronic smoking reveals a suppressed innate immune response and activation of differentiation pathways.


Keywords

  • Age-related macular degeneration
  • Aging
  • Differentiation
  • Innate immunity
  • RNA sequencing
  • Smoking


Differences in Intraretinal Pigment Migration Across Inherited Retinal Dystrophies.


MeSH Terms

  • Adult
  • Aging
  • Cell Movement
  • Female
  • Follow-Up Studies
  • Humans
  • Male
  • Ophthalmoscopy
  • Retinal Dystrophies
  • Retinal Pigment Epithelium
  • Retrospective Studies
  • Slit Lamp Microscopy
  • Tomography, Optical Coherence


Exosomal MiRNA Transfer between Retinal Microglia and RPE.


Keywords

  • RPE
  • aging
  • exosome
  • inflammation
  • microglia


Functionally validated imaging endpoints in the Alabama study on early age-related macular degeneration 2 (ALSTAR2): design and methods.


Keywords

  • Age-related macular degeneration
  • Aging
  • Cones
  • Dark adaptation
  • Light sensitivity
  • Macula
  • Quantitative autofluorescence
  • Retina
  • Rods
  • Spectral domain optical coherence tomography


Mechanisms of mitochondrial dysfunction and their impact on age-related macular degeneration.


Keywords

  • Age-related macular degeneration
  • Aggregation
  • Aging
  • Autophagy
  • Clearance
  • Degeneration
  • Mitochondria
  • Mitophagy
  • Retina
  • Retinal pigment epithelium


CSF1R blockade induces macrophage ablation and results in mouse choroidal vascular atrophy and RPE disorganization.


Keywords

  • RPE disorganization
  • aging
  • choroid
  • choroidal macrophage
  • choroidal vasculature
  • immunology
  • inflammation
  • mouse
  • neuroscience


Extracellular microparticles exacerbate oxidative damage to retinal pigment epithelial cells.


Keywords

  • Extracellular vesicles
  • Oxidative stress
  • Phagocytosis
  • RPE cell Dysfunction
  • RPE cell-Derived microparticles (RMPs)
  • Retinal pigment epithelial cell (RPE)
  • Senescence


Water-based continuous and interval training in older women: Cardiorespiratory and neuromuscular outcomes (WATER study).


Keywords

  • Aerobic capacity
  • Aerobic training
  • Aging
  • Aquatic exercise
  • Interval exercise
  • Muscle echo intensity
  • Muscle strength
  • Muscle thickness


Retrieval Practice Improves Recollection-Based Memory Over a Seven-Day Period in Younger and Older Adults.


Keywords

  • aging
  • recollection and familiarity
  • retrieval practice
  • temporal dynamics
  • testing effect


A Comparison of Heart Rate Training Load and Perceptual Effort Between Masters and Young Cyclists


MeSH Terms

  • Adult
  • Aging
  • Bicycling
  • Heart Rate
  • High-Intensity Interval Training
  • Humans
  • Middle Aged
  • Perception
  • Physical Exertion

Keywords

  • age
  • endurance training
  • high-intensity interval training
  • older athlete


Retinal Pigment Epithelial Cells: The Unveiled Component in the Etiology of Prpf Splicing Factor-Associated Retinitis Pigmentosa.


MeSH Terms

  • Animals
  • Circadian Rhythm
  • Epithelial Cells
  • Eye Proteins
  • Humans
  • Mice
  • Phagocytosis
  • Photoreceptor Cells, Vertebrate
  • RNA Splicing Factors
  • Retinal Pigment Epithelium
  • Retinitis Pigmentosa

Keywords

  • Aging
  • Cellular stress
  • Circadian rhythm
  • Metabolism
  • PRPF
  • Phagocytosis
  • Retinal pigment epithelium
  • Retinitis pigmentosa
  • Splicing factors


AMPK May Play an Important Role in the Retinal Metabolic Ecosystem.


MeSH Terms

  • AMP-Activated Protein Kinases
  • Animals
  • DNA Damage
  • DNA, Mitochondrial
  • Disease Models, Animal
  • Gene Dosage
  • Metformin
  • Mice
  • Oxidative Stress
  • Retina
  • Retinal Degeneration
  • Retinitis Pigmentosa

Keywords

  • AMPK
  • Adenosine monophosphate-activated protein kinase
  • Aging
  • Glycolysis
  • Metabolism
  • Neuroprotection
  • Retina


Stem cell-derived retinal pigment epithelium from patients with age-related macular degeneration exhibit reduced metabolism and matrix interactions.


Keywords

  • Bruch's membrane
  • age-related macular degeneration
  • aging
  • induced pluripotent stem cells
  • nonenzymatic nitration
  • retinal pigment epithelium


Elovanoids counteract oligomeric β-amyloid-induced gene expression and protect photoreceptors.


MeSH Terms

  • Amyloid beta-Peptides
  • Animals
  • Apoptosis
  • Autophagy
  • Cells, Cultured
  • Docosahexaenoic Acids
  • Extracellular Matrix
  • Fatty Acids, Omega-3
  • Gene Expression Regulation
  • Humans
  • Male
  • Mice, Inbred C57BL
  • Mice, Transgenic
  • Photoreceptor Cells
  • Retina
  • Retinal Pigment Epithelium
  • Young Adult

Keywords

  • SASP
  • age-related macular degeneration
  • p16
  • retinal pigment epithelial cells
  • senescence gene program


Genetic LAMP2 deficiency accelerates the age-associated formation of basal laminar deposits in the retina.


MeSH Terms

  • Aging
  • Animals
  • Basement Membrane
  • Bruch Membrane
  • Exocytosis
  • Humans
  • Lysosomal-Associated Membrane Protein 2
  • Lysosomes
  • Macular Degeneration
  • Mice
  • Mice, Knockout
  • Phagocytosis
  • Retina
  • Retinal Pigment Epithelium

Keywords

  • LAMP2
  • aging
  • lysosome
  • retinal degeneration


Age, lipofuscin and melanin oxidation affect fundus near-infrared autofluorescence.


MeSH Terms

  • Age Factors
  • Animals
  • Biomarkers
  • Choroid
  • Disease Models, Animal
  • Female
  • Fluorescein Angiography
  • Fundus Oculi
  • Humans
  • Lipofuscin
  • Macular Degeneration
  • Male
  • Melanins
  • Melanosomes
  • Mice
  • Mice, Knockout
  • Optical Imaging
  • Oxidation-Reduction
  • Oxidative Stress
  • Protein Transport
  • Retinal Pigment Epithelium
  • Tomography, Optical Coherence

Keywords

  • Aging
  • Lipofuscin
  • Melanin
  • Melanolipofuscin
  • Oxidative stress


Relevance of working memory for reinforcement learning in older adults varies with timescale of learning.


Keywords

  • Aging
  • computational modeling
  • individual differences
  • reinforcement learning
  • working memory


Expression and Function of Mas-Related G Protein-Coupled Receptor D and Its Ligand Alamandine in Retina.


MeSH Terms

  • Aging
  • Angiotensin II
  • Animals
  • Cells, Cultured
  • Electroretinography
  • Humans
  • Ligands
  • Lipopolysaccharides
  • Mice, Inbred C57BL
  • Mice, Knockout
  • Oligopeptides
  • Rats
  • Reactive Oxygen Species
  • Receptors, G-Protein-Coupled
  • Retina

Keywords

  • Alamandine
  • Angiotensin-(1–7)
  • Mas-related G protein-coupled receptor D
  • Rennin-angiotensin system
  • Retina

RPIA[править]

Suppression of p16 Induces mTORC1-Mediated Nucleotide Metabolic Reprogramming.


MeSH Terms

  • Aldose-Ketose Isomerases
  • Animals
  • Cell Line
  • Cellular Senescence
  • Cyclin-Dependent Kinase Inhibitor p16
  • Gene Knockdown Techniques
  • Humans
  • Male
  • Mechanistic Target of Rapamycin Complex 1
  • Mice, SCID
  • Nucleotides
  • Pentose Phosphate Pathway
  • Protein Biosynthesis

Keywords

  • BRAF
  • cancer metabolism
  • cell cycle
  • melanoma
  • nevi
  • pancreatic cancer
  • pentose phosphate pathway
  • ribonucleotide reductase M2
  • ribose-5-phosphate isomerase A
  • senescence

RPS19BP1[править]

Material basis, effect, and mechanism of ethanol extract of Pinellia ternata tubers on oxidative stress-induced cell senescence.


Keywords

  • Oxidative stress
  • Pinellia ternata
  • SIRT1
  • Senescence

RTEL1[править]

Telomere length and aging-related outcomes in humans: A Mendelian randomization study in 261,000 older participants.


MeSH Terms

  • Adult
  • Aged
  • Aged, 80 and over
  • Aging
  • Cohort Studies
  • Female
  • Humans
  • Male
  • Mendelian Randomization Analysis
  • Middle Aged
  • Risk Factors
  • Telomere Homeostasis

Keywords

  • TERT
  • UK Biobank
  • anti-aging
  • cellular senescence
  • centenarians
  • frailty
  • longevity
  • sarcopenia

RXFP3[править]

The RXFP3 receptor is functionally associated with cellular responses to oxidative stress and DNA damage.


MeSH Terms

  • Camptothecin
  • Computational Biology
  • DNA Damage
  • Felodipine
  • GTPase-Activating Proteins
  • Gene Expression Regulation
  • Gene Regulatory Networks
  • HEK293 Cells
  • Humans
  • Oxidative Stress
  • RNA, Messenger
  • Receptors, G-Protein-Coupled
  • Topoisomerase I Inhibitors

Keywords

  • DNA damage
  • GPCR
  • aging
  • relaxin 3
  • relaxin family peptide 3 receptor

S100A4[править]

Protective role of mesenchymal stem cells and mesenchymal stem cell-derived exosomes in cigarette smoke-induced mitochondrial dysfunction in mice.


MeSH Terms

  • Alarmins
  • Animals
  • Cytokines
  • Exosomes
  • Lung
  • Mesenchymal Stem Cells
  • Mice
  • Mitochondria
  • Mitophagy
  • Oxidative Phosphorylation
  • Smoke
  • Tobacco

Keywords

  • COPD
  • Cellular Senescence
  • Exosomes
  • Mesenchymal stem cells
  • Mitochondria

S100A9[править]

Cigarette smoke induction of S100A9 contributes to chronic obstructive pulmonary disease.


Keywords

  • Cigarette smoke
  • S100A9
  • aging
  • kinase
  • pulmonary function


Modulation of KDM1A with vafidemstat rescues memory deficit and behavioral alterations.


MeSH Terms

  • Aging
  • Alzheimer Disease
  • Animals
  • Behavior, Animal
  • Brain
  • Disease Models, Animal
  • Enzyme Inhibitors
  • Epigenesis, Genetic
  • Female
  • Gene Expression
  • Hippocampus
  • Histone Demethylases
  • Humans
  • Male
  • Memory Disorders
  • Mice
  • Mice, Inbred C57BL
  • Mice, Mutant Strains
  • Monoamine Oxidase Inhibitors
  • Oxadiazoles
  • Rats
  • Rats, Sprague-Dawley


Cellular senescence induced by S100A9 in mesenchymal stromal cells through NLRP3 inflammasome activation.


MeSH Terms

  • Adolescent
  • Adult
  • Aged
  • Aged, 80 and over
  • Calgranulin B
  • Case-Control Studies
  • Cell Line
  • Cells, Cultured
  • Cellular Reprogramming
  • Cellular Senescence
  • Female
  • Humans
  • Inflammasomes
  • Interleukin-1beta
  • Male
  • Mesenchymal Stem Cells
  • Middle Aged
  • Myelodysplastic Syndromes
  • NLR Family, Pyrin Domain-Containing 3 Protein
  • Reactive Oxygen Species
  • Signal Transduction
  • Stem Cell Niche
  • Toll-Like Receptor 4
  • Up-Regulation
  • Young Adult

Keywords

  • NLRP3
  • S100A9
  • cellular senescence
  • mesenchymal stromal cells
  • myelodysplastic syndromes


S100A9 extends lifespan in insulin deficiency.


MeSH Terms

  • Animals
  • Calgranulin B
  • Diabetes Mellitus, Experimental
  • Diphtheria Toxin
  • Fatty Acids
  • Humans
  • Hyperglycemia
  • Insulin
  • Leptin
  • Liver
  • Longevity
  • Male
  • Mice
  • Mice, Knockout
  • Oxidation-Reduction
  • Signal Transduction
  • Streptozocin
  • Toll-Like Receptor 4

S100B[править]

Aging protects rat cortical slices against to oxygen-glucose deprivation induced damage.


Keywords

  • Aging
  • LDH
  • S100B
  • edema
  • oxygen-glucose deprivation

S1PR1[править]

Aging Suppresses Sphingosine-1-Phosphate Chaperone ApoM in Circulation Resulting in Maladaptive Organ Repair.


Keywords

  • aging
  • endothelial cell
  • fibrosis
  • kidney repair
  • lipoprotein
  • lung regeneration
  • sphingosine-1-phosphate receptor
  • vascular barrier
  • vascular niche

SAG[править]

WRKY42 transcription factor positively regulates leaf senescence through modulating SA and ROS synthesis in Arabidopsis thaliana.


Keywords

WRKY42

  • Arabidopsis
  • leaf senescence
  • reactive oxygen species
  • salicylic acid


Neurogenesis in the inner ear: the zebrafish statoacoustic ganglion provides new neurons from a Neurod/Nestin-positive progenitor pool well into adulthood.


MeSH Terms

  • Adult Stem Cells
  • Aging
  • Animals
  • Animals, Genetically Modified
  • Basic Helix-Loop-Helix Transcription Factors
  • Cell Differentiation
  • Ear, Inner
  • Embryo, Nonmammalian
  • Ganglia, Sensory
  • Gene Expression Regulation, Developmental
  • Hair Cells, Auditory
  • Larva
  • Nerve Tissue Proteins
  • Nestin
  • Neural Stem Cells
  • Neurogenesis
  • Sensory Receptor Cells
  • Stem Cell Niche
  • Zebrafish

Keywords

  • Inner ear
  • Neuronal stem cells
  • PNS
  • Zebrafish

SAT1[править]

Triethylenetetramine (trientine): a caloric restriction mimetic with a new mode of action.


Keywords

  • Acetylation
  • SAT1
  • aging
  • autophagy
  • copper
  • metabolomics
  • obesity
  • spermidine

SATB1[править]

Loss of SATB1 Induces p21-Dependent Cellular Senescence in Post-mitotic Dopaminergic Neurons.


MeSH Terms

  • Aging
  • Animals
  • Cells, Cultured
  • Cellular Senescence
  • Cyclin-Dependent Kinase Inhibitor p21
  • Dopaminergic Neurons
  • Epigenetic Repression
  • Gene Knockdown Techniques
  • Humans
  • Matrix Attachment Region Binding Proteins
  • Mice
  • Mice, Knockout
  • Mitosis
  • Parkinson Disease
  • Protein Binding

Keywords

  • Parkinson’s disease
  • SATB1
  • cellular senescence
  • dopamine
  • neurodegeneration
  • neuroinflammation
  • p21
  • senolytics
  • stem cells
  • transcriptomics

SCD[править]

Cognitive training and brain stimulation in prodromal Alzheimer's disease (AD-Stim)-study protocol for a double-blind randomized controlled phase IIb (monocenter) trial.


Keywords

  • Aging
  • Decision-making
  • Mild cognitive impairment
  • Subjective cognitive decline
  • Transcranial direct current stimulation
  • Transfer
  • Working memory


Blood Pressure in Different Dementia Disorders, Mild Cognitive Impairment, and Subjective Cognitive Decline.


Keywords

  • Alzheimer’s disease
  • aging
  • blood pressure
  • mild cognitive impairment
  • subjective cognitive decline


Known-Groups and Convergent Validity of the Telephone Rey Auditory Verbal Learning Test total Learning Scores for Distinguishing Between Older Adults With Amnestic Cognitive Impairment and Subjective Cognitive Decline.


Keywords

  • aging
  • cognitive impairment
  • neuropsychological assessment


Subjective cognitive decline as a predictor of future cognitive decline: a systematic review.


Keywords

  • Alzheimer disease.
  • aging
  • cognition
  • cognitive dysfunction
  • dementia


Geriatric assessment for older adults with sickle cell disease: protocol for a prospective cohort pilot study.


Keywords

  • Aging
  • Functional assessment
  • Geriatric assessment
  • Geriatrics
  • Older adults
  • Sickle cell


Prevalence and psychosocial correlates of subjectively perceived decline in five cognitive domains: Results from a population-based cohort study in Germany.


Keywords

  • Germany
  • cognitive aging
  • cognitive complaints
  • cohort study
  • prevalence
  • subjective cognitive decline


SC411 treatment can enhance survival in a mouse model of sickle cell disease.


Keywords

  • Aging
  • Cerebral blood flow
  • Docosahexaenoic acid
  • Neuroinflammation
  • Sickle cell disease
  • Working memory


DNA fragmentation of human spermatozoa: Simple assessment of single- and double-strand DNA breaks and their respective dynamic behavioral response.


Keywords

  • DNA longevity
  • sperm DNA damage
  • sperm DNA dynamics
  • sperm DNA fragmentation
  • sperm chromatin dispersion test


Psychometric Cognitive Decline Precedes the Advent of Subjective Cognitive Decline in the Evolution of Alzheimer's Disease.


Keywords

  • Alzheimer’s disease
  • Brain aging
  • Cognitive decline
  • Cognitive testing
  • Longitudinal studies
  • Psychometric cognition


Serum alkaline phosphatase is elevated and inversely correlated with cognitive functions in subjective cognitive decline: results from the ReGAl 2.0 project.


Keywords

  • Aging
  • Biochemistry
  • Cognition
  • Dementia
  • Geriatric medicine


Changes in Activity Participation Among Older Adults With Subjective Cognitive Decline or Objective Cognitive Deficits.


Keywords

  • activity participation
  • aging
  • daily functioning
  • metamemory
  • subjective cognitive decline


Age, gender and drug therapy influences on Tpeak-tend interval and on electrical risk score.


Keywords

  • Aging
  • Electrical risk score
  • Gender
  • Mortality
  • QTc
  • Repolarization phase
  • T peak-tend interval


Comorbid Chronic Conditions Among Older Adults with Subjective Cognitive Decline, United States, 2015-2017.


Keywords

  • Aging
  • Chronic disease
  • Cognitive dysfunction
  • Dementia


Resting State BOLD Variability Is Linked to White Matter Vascular Burden in Healthy Aging but Not in Older Adults With Subjective Cognitive Decline.


Keywords

  • Alzheimer’s disease
  • aging
  • biomarkers
  • cerebrovascular health
  • signal variability
  • subjective cognitive decline
  • white matter


Estimated Life Expectancy and Income of Patients With Sickle Cell Disease Compared With Those Without Sickle Cell Disease.


MeSH Terms

  • Adolescent
  • Adult
  • Aged
  • Anemia, Sickle Cell
  • Child
  • Child, Preschool
  • Cohort Studies
  • Female
  • Forecasting
  • Humans
  • Income
  • Infant
  • Life Expectancy
  • Male
  • Middle Aged
  • Models, Statistical
  • Quality-Adjusted Life Years
  • United States
  • Young Adult


Does Empirically Derived Classification of Individuals with Subjective Cognitive Complaints Predict Dementia?


Keywords

  • Compostela aging study
  • cluster analysis
  • cognitive aging
  • dementia
  • mild cognitive impairment
  • screening and diagnosis
  • subjective cognitive complaints


Spatiotemporal Oscillatory Patterns During Working Memory Maintenance in Mild Cognitive Impairment and Subjective Cognitive Decline.


MeSH Terms

  • Aged
  • Aging
  • Brain Waves
  • Cerebral Cortex
  • Cognitive Dysfunction
  • Cortical Synchronization
  • Female
  • Humans
  • Magnetoencephalography
  • Male
  • Memory, Short-Term
  • Task Performance and Analysis

Keywords

  • Alzheimer’s disease (AD)
  • Induced oscillatory activity
  • magnetoencephalography (MEG)
  • mild cognitive impairment (MCI)
  • subjective cognitive decline (SCD)
  • working memory (WM)


Microstructural Correlates and Laterality Effect of Prospective Memory in Non-Demented Adults with Memory Complaints.


MeSH Terms

  • Aged
  • Aged, 80 and over
  • Corpus Callosum
  • Diffusion Tensor Imaging
  • Female
  • Frontal Lobe
  • Functional Laterality
  • Humans
  • Magnetic Resonance Imaging
  • Male
  • Memory Disorders
  • Middle Aged
  • Nerve Fibers
  • Neuropsychological Tests
  • Retrospective Studies
  • Surveys and Questionnaires
  • Taiwan

Keywords

  • Aging
  • Alzheimer’s disease
  • Cognitive complaints
  • Diffusion tensor imaging
  • Lateralization
  • Prospective memory
  • Tract-based spatial statistics

SCN2A[править]

Na 1.2 haploinsufficiency in Scn2a knock-out mice causes an autistic-like phenotype attenuated with age.


MeSH Terms

  • Aging
  • Animals
  • Autism Spectrum Disorder
  • Gene Knockout Techniques
  • Haploinsufficiency
  • Memory
  • Mice
  • NAV1.2 Voltage-Gated Sodium Channel
  • Phenotype
  • Spatial Learning

SCN2B[править]

MicroRNA‑449a regulates the progression of brain aging by targeting SCN2B in SAMP8 mice.


MeSH Terms

  • Aging
  • Animals
  • Brain
  • Gene Expression Regulation
  • Male
  • Mice
  • Mice, Transgenic
  • MicroRNAs
  • Voltage-Gated Sodium Channel beta-2 Subunit

SCO1[править]

Real-Time PCR Analysis of Metabolism-Related Genes in a Long-Lived Model of C. elegans.


Keywords

  • Caenorhabditis elegans
  • Energy metabolism
  • Longevity
  • TaqMan real-time PCR
  • p53/CEP-1

SDC1[править]

Olmesartan alleviates bleomycin-mediated vascular smooth muscle cell senescence via the miR-665/SDC1 axis.


Keywords

  • Atherosclerosis
  • MiR-665
  • SDC1
  • olmesartan
  • vascular smooth muscle cell senescence


Sulfated syndecan 1 is critical to preventing cellular senescence by modulating fibroblast growth factor receptor endocytosis.


Keywords

  • FGFR1
  • SDC1
  • cellular senescence
  • endocytosis
  • heparan sulfation

SDHB[править]

Mitochondrial Signatures in Circulating Extracellular Vesicles of Older Adults with Parkinson's Disease: Results from the EXosomes in PArkiNson's Disease (EXPAND) Study.


Keywords

  • aging
  • biomarkers
  • exosomes
  • mitochondrial dynamics
  • mitochondrial quality control
  • mitochondrial-derived vesicles
  • mitochondrial-lysosomal axis
  • mitophagy

SDS[править]

Semiautomatic morphometric analysis of skeletal muscle obtained by needle biopsy in older adults.


Keywords

  • Aging skeletal muscle
  • Morphometric analysis
  • Myosin heavy chain
  • Semiautomatic muscle analysis
  • Skeletal muscle


Effects of late-onset dietary intake of salidroside on insulin/insulin-like growth factor-1 (IGF-1) signaling pathway of the annual fish Nothobranchius guentheri.


Keywords

  • Aging
  • Annual fish
  • Lifespan
  • Nothobranchius
  • Salidroside


Quantification of Insoluble Protein Aggregation in Caenorhabditis elegans during Aging with a Novel Data-Independent Acquisition Workflow.


MeSH Terms

  • Aging
  • Animals
  • Caenorhabditis elegans
  • Caenorhabditis elegans Proteins
  • Longevity
  • Protein Aggregates
  • Proteome
  • Proteomics
  • Workflow


Skeletal Muscle Myofibrillar Protein Abundance Is Higher in Resistance-Trained Men, and Aging in the Absence of Training May Have an Opposite Effect.


Keywords

  • aging
  • myofibrillar protein
  • proteomics
  • resistance training
  • sarcoplasmic protein


Characterization, evaluation of nutritional parameters of Radix isatidis protein and its antioxidant activity in D-galactose induced ageing mice.


MeSH Terms

  • Aging
  • Animals
  • Antioxidants
  • Catalase
  • Drugs, Chinese Herbal
  • Galactose
  • Humans
  • Kidney
  • Liver
  • Male
  • Malondialdehyde
  • Mice
  • Mice, Inbred ICR
  • Molecular Weight
  • Oxidative Stress
  • Plant Proteins
  • Plant Roots
  • Superoxide Dismutase

Keywords

  • Antioxidant activity
  • D-galactose
  • Oxidative damage
  • Protein composition
  • Radix isatidis protein


[Effects of silver nanoparticles on pupation, eclosion, life span, apoptosis and protein expression in Drosophila melanogaster].


MeSH Terms

  • Animals
  • Apoptosis
  • Drosophila melanogaster
  • Longevity
  • Metal Nanoparticles
  • Oregon
  • Silver

Keywords

  • Drosophila melanogaster
  • apoptosis
  • protein expression
  • silver nanoparticles


Does an Age-Specific Treatment Program Augment the Efficacy of a Cognitive-Behavioral Weight Loss Program in Adolescence and Young Adulthood? Results from a Controlled Study.


MeSH Terms

  • Adolescent
  • Aging
  • Behavior Therapy
  • Cognitive Behavioral Therapy
  • Female
  • Humans
  • Male
  • Weight Loss
  • Weight Reduction Programs
  • Young Adult

Keywords

  • adolescents
  • behavioral weight loss
  • controlled trial
  • emerging adults
  • obesity
  • quality of life

SELENBP1[править]

A Caenorhabditis elegans ortholog of human selenium-binding protein 1 is a pro-aging factor protecting against selenite toxicity.


MeSH Terms

  • Animals
  • Caenorhabditis elegans
  • Caenorhabditis elegans Proteins
  • Cytoplasm
  • Drug Resistance
  • Gene Expression Regulation
  • Humans
  • Longevity
  • Membrane Proteins
  • Oxidative Stress
  • Paraquat
  • Selenious Acid
  • Selenium-Binding Proteins
  • Structural Homology, Protein

Keywords

  • Caenorhabditis elegans
  • Lifespan
  • Selenium-binding protein
  • Stress signaling

SELENOK[править]

Dietary selenium deficiency and supplementation differentially modulate the expression of two ER-resident selenoproteins (selenoprotein K and selenoprotein M) in the ovaries of aged mice: Preliminary data.


Keywords

  • Female fertility
  • Ovarian aging
  • Selenium
  • Selenoprotein K
  • Selenoprotein M

SENP6[править]

Molecular signature for senile and complicated cataracts derived from analysis of sumoylation enzymes and their substrates in human cataract lenses.


Keywords

  • Pax6
  • SUMO1
  • SUMO2/3
  • aging
  • apoptosis
  • cataract
  • de-sumoylation enzymes (SENPs)
  • sumoylation ligases

SERPINE1[править]

Elevated circulating HtrA4 in preeclampsia may alter endothelial expression of senescence genes.


Keywords

  • Endothelial aging
  • Endothelial cells
  • HtrA4
  • Preeclampsia
  • Senescence

SESN2[править]

Copy Number Alterations in Papillary Thyroid Carcinomas: Does Loss of [i]SESN2[/i] Have a Role in Age-related Different Prognoses?


Keywords

  • Papillary thyroid cancer
  • SESN2
  • aCGH
  • deletion
  • senescence

SFN[править]

The phytoprotective agent sulforaphane prevents inflammatory degenerative diseases and age-related pathologies via Nrf2-mediated hormesis.


Keywords

  • Aging
  • Hormesis
  • Inflammation
  • Neuroprotection
  • Nrf2
  • Sulforaphane


Multi-Omic Analysis Reveals Different Effects of Sulforaphane on the Microbiome and Metabolome in Old Compared to Young Mice.


Keywords

  • aging
  • biomarkers
  • gut microbiome
  • metabolome
  • sulforaphane


Sulforaphane controls the release of paracrine factors by keratinocytes and thus mitigates particulate matter-induced premature skin aging by suppressing melanogenesis and maintaining collagen homeostasis.


Keywords

  • Coculture system
  • Collagen homeostasis
  • Melanogenesis
  • Particulate matter 2.5
  • Premature skin aging
  • Sulforaphane


Sulforaphane Inhibits Autophagy and Induces Exosome-Mediated Paracrine Senescence via Regulating mTOR/TFE3.


Keywords

  • ROS
  • autophagy
  • exosome
  • senescence
  • sulforaphane

SFPQ[править]

Downregulation of LncRNA NORAD promotes Ox-LDL-induced vascular endothelial cell injury and atherosclerosis.


Keywords

  • IL-8
  • NORAD
  • cell apoptosis
  • cell senescence
  • ox-LDL

SGK1[править]

Epigenetic Regulation of KL (Klotho) via H3K27me3 (Histone 3 Lysine [K] 27 Trimethylation) in Renal Tubule Cells.


Keywords

  • AKT
  • EZH2
  • aging
  • mTOR
  • p53

SHBG[править]

Endogenous Testosterone Levels and the Risk of Incident Cardiovascular Events in Elderly Men: The MrOS Prospective Study.


Keywords

  • aging
  • cardiovascular events
  • men
  • testosterone


Associations of Endogenous Sex Hormones with Carotid Plaque Burden and Characteristics in Midlife Women.


Keywords

  • aging
  • atherosclerosis
  • carotid artery
  • hormones
  • women


Analysis of the Relationship between the Levels of Androgens and Biochemical Bone Markers in Men Aged 60-75 Years.


MeSH Terms

  • Absorptiometry, Photon
  • Aged
  • Aging
  • Androgens
  • Biomarkers
  • Bone Density
  • Bone Remodeling
  • Bone and Bones
  • Collagen Type I
  • Dehydroepiandrosterone Sulfate
  • Estradiol
  • Humans
  • Male
  • Middle Aged
  • Parathyroid Hormone
  • Peptide Fragments
  • Peptides
  • Procollagen
  • Sex Hormone-Binding Globulin
  • Testosterone

Keywords

  • aging men
  • biochemical bone markers
  • levels of androgens


Testosterone and Estrone Increase From the Age of 70 Years: Findings From the Sex Hormones in Older Women Study.


MeSH Terms

  • Aged
  • Aged, 80 and over
  • Aging
  • Biomarkers
  • Community-Based Participatory Research
  • Cross-Sectional Studies
  • Dehydroepiandrosterone
  • Estrone
  • Female
  • Follow-Up Studies
  • Humans
  • Obesity
  • Overweight
  • Prognosis
  • Testosterone

SHD[править]

Does self-reported hearing difficulty decrease older adults' cognitive and physical functioning? The mediating role of social isolation.


MeSH Terms

  • Activities of Daily Living
  • Aged
  • Aged, 80 and over
  • Cognition
  • Cognitive Dysfunction
  • Cohort Studies
  • Disabled Persons
  • Female
  • Health Status
  • Hearing Loss
  • Humans
  • Longevity
  • Longitudinal Studies
  • Male
  • Mental Status and Dementia Tests
  • Odds Ratio
  • Self Report
  • Social Isolation

Keywords

  • Cognitive impairment
  • Older people
  • Physical disability
  • Self-reported hearing difficulty
  • Social isolation

SHH[править]

Recent advances in SHH medulloblastoma progression: tumor suppressor mechanisms and the tumor microenvironment.


MeSH Terms

  • Animals
  • Cerebellar Neoplasms
  • Cerebellum
  • Hedgehog Proteins
  • Humans
  • Medulloblastoma
  • Mice
  • Tumor Microenvironment

Keywords

  • Medulloblastoma
  • Sonic hedgehog
  • cell senescence
  • tumor microenvironment
  • tumor progression

SI[править]

Microarray Profiling Reveals Distinct Circulating miRNAs in Aged Male and Female Mice Subjected to Post-stroke Social Isolation.


Keywords

  • Aging
  • Biomarkers
  • Sex differences
  • Social isolation
  • Stroke
  • miRNAs


Is Heart Rate a Confounding Factor for Photoplethysmography Markers? A Systematic Review.


MeSH Terms

  • Aging
  • Cardiovascular Diseases
  • Diabetes Mellitus, Type 2
  • Female
  • Fingers
  • Heart Rate
  • Humans
  • Male
  • Microcirculation
  • Photoplethysmography
  • Vascular Stiffness

Keywords

  • cardiovascular disease
  • heart rate
  • photoplethysmography
  • reflection index
  • second derivative of photoplethysmography
  • stiffness index


Survival time after marked reduction in oral intake in terminally ill noncancer patients: A retrospective study.


Keywords

  • elderly
  • geriatrics
  • palliative medicine


Adherence to Mediterranean diet moderates the association between multimorbidity and depressive symptoms in older adults.


MeSH Terms

  • Aged
  • Aged, 80 and over
  • Cohort Studies
  • Depression
  • Diet, Mediterranean
  • Healthy Aging
  • Humans
  • Multimorbidity
  • Surveys and Questionnaires

Keywords

  • Aging
  • Depressive symptoms
  • Mediterranean diet
  • Mental health
  • Multimorbidity


Loneliness, Social Isolation, and Objectively Measured Physical Activity in Rural-Living Older Adults.


Keywords

  • accelerometry
  • aging
  • health
  • social well-being
  • volunteering


The associations between social support and negative social interaction with suicidal ideation in US Chinese older adults.


Keywords

  • Chinese American
  • Social support
  • aging
  • negative social interaction
  • suicidal ideation


Cell Senescence and Cerebral Small Vessel Disease in the Brains of People Aged 80 Years and Older.


MeSH Terms

  • Aged, 80 and over
  • Aging
  • Brain
  • Cellular Senescence
  • Cerebral Arteries
  • Cerebral Small Vessel Diseases
  • Female
  • Humans
  • Male
  • White Matter

Keywords

  • Brain aging
  • Cerebrovascular disease
  • Senescence
  • Small vessel disease

SIK3[править]

Quantitative and Qualitative Role of Antagonistic Heterogeneity in Genetics of Blood Lipids.


Keywords

  • Age-related phenotypes
  • Aging
  • Genome-wide association studies
  • Health span
  • Life span
  • Pleiotropy

SIRT1[править]

Anthocyanins attenuate endothelial dysfunction through regulation of uncoupling of nitric oxide synthase in aged rats.


Keywords

  • NO
  • SIRT1
  • anthocyanins
  • eNOS deacetylation
  • senescence


Sirtuins and Their Implications in Neurodegenerative Diseases from a Drug Discovery Perspective.


Keywords

  • Aging
  • neurodegenerative diseases
  • neuroprotective
  • sirtuin
  • sirtuin activators
  • sirtuin inhibitors


Effects of alpha-mangostin on memory senescence induced by high glucose in human umbilical vein endothelial cells.


Keywords

  • Cellular senescence
  • Diabetes
  • Diabetes complications
  • Endothelial cells
  • Garcinia mangostana
  • Hyperglycemia
  • Mangostin
  • Metabolic syndrome


SIRT1 Activation Using CRISPR/dCas9 Promotes Regeneration of Human Corneal Endothelial Cells through Inhibiting Senescence.


Keywords

  • CRISPR/dCas9
  • SIRT1
  • corneal endothelial cells
  • senescence


Histone Deacetylase SIRT1, Smooth Muscle Cell Function, and Vascular Diseases.


Keywords

  • SIRT1
  • SIRT1 activators
  • calorie restriction
  • senescence
  • vascular diseases
  • vascular smooth muscle cells


6,4'-dihydroxy-7-methoxyflavanone protects against H O -induced cellular senescence by inducing SIRT1 and inhibiting phosphatidylinositol 3-kinase/Akt pathway activation.


Keywords

  • 6,4′-dihydroxy-7-methoxyflavanone
  • Akt
  • Oxidative stress
  • Premature senescence
  • SIRT1


Isoparvifuran isolated from Dalbergia odorifera attenuates H O -induced senescence of BJ cells through SIRT1 activation and AKT/mTOR pathway inhibition.


Keywords

  • AKT/mTOR signaling pathway
  • Antioxidant: SIRT1
  • Cellular senescence
  • Isoparvifuran


SIRT1 Is the Target Gene for 2,3,5,4'-Tetrahydroxystilbene-2-O-β-D-Glucoside Alleviating the HUVEC Senescence.


Keywords

  • 2,3,5,4’-tetrahydroxystilbene-2-O-β-d-glucoside
  • SIRT1
  • human umbilical vein cells
  • hydrogen peroxide
  • senescence


The Role of Sirtuins in Kidney Diseases.


Keywords

  • acute kidney injury
  • aging kidney
  • chronic kidney disease
  • diabetic nephropathy
  • kidney
  • sirtuins


The effect of 12-week resistance exercise training on serum levels of cellular aging process parameters in elderly men.


Keywords

  • Cellular senescence
  • Elderly
  • Resistance training


Virus-Induced Asthma Exacerbations: SIRT1 Targeted Approach.


Keywords

  • SIRT1
  • asthma
  • cellular senescence
  • exacerbations
  • virus infection


Novel resveratrol derivatives have diverse effects on the survival, proliferation and senescence of primary human fibroblasts.


Keywords

  • Resveratrol
  • SIRT1
  • Senescence
  • Toxicity


Glucose restriction delays senescence and promotes proliferation of HUVECs via the AMPK/SIRT1-FOXA3-Beclin1 pathway.


Keywords

  • Beclin1
  • Endothelial cells
  • FOXA3
  • Glucose restriction
  • Proliferation
  • Senescence


Therapeutic Effects of SRT2104 on Lung Injury in Rats with Emphysema via Reduction of Type II Alveolar Epithelial Cell Senescence.


Keywords

  • Sirtuin 1
  • alveolar epithelial cells
  • cellular senescence
  • chronic obstructive pulmonary disease
  • cigarette smoking


Latifolin Inhibits Oxidative Stress-Induced Senescence via Upregulation of SIRT1 in Human Dermal Fibroblasts.


Keywords

  • human dermal fibroblast
  • latifolin
  • mammalian target of rapamycin
  • oxidative stress
  • senescence
  • silent information regulator 1


SRT1720-induced activation of SIRT1 alleviates vascular smooth muscle cell senescence through PKA-dependent phosphorylation of AMPKα at Ser485.


Keywords

  • SIRT1
  • SRT1720
  • VSMC senescence
  • p-AMPK (Ser485)
  • telomere length


miR-128 plays a critical role in murine osteoclastogenesis and estrogen deficiency-induced bone loss.


Keywords

  • PMOP
  • aging
  • inflammation
  • miR-128
  • osteoclastogenesis
  • ovariectomy


Lymphocyte senescence in COPD is associated with decreased sirtuin 1 expression in steroid resistant pro-inflammatory lymphocytes.


Keywords

  • CD28nullCD8+ T and NKT-like cells
  • COPD
  • IFNγ and TNFα
  • SIRT1
  • lymphocyte senescence


Therapeutic effects of hydro-alcoholic leaf extract of Withania somnifera on age-induced changes in daily rhythms of Sirt1, Nrf2 and Rev-erbα in the SCN of male Wistar rats.


Keywords

  • Aging
  • Ashwagandha
  • Circadian clock
  • NRF2
  • SCN
  • SIRT1


The Serum Concentration of Anti-Aging Proteins, Sirtuin1 and αKlotho in Patients with End-Stage Kidney Disease on Maintenance Hemodialysis.


MeSH Terms

  • Age Factors
  • Aged
  • Aging
  • Biomarkers
  • Blood Pressure
  • Cardiovascular Diseases
  • Case-Control Studies
  • Diabetes Complications
  • Echocardiography
  • Female
  • Glucuronidase
  • Heart Ventricles
  • Humans
  • Kidney
  • Kidney Failure, Chronic
  • Male
  • Middle Aged
  • Renal Dialysis
  • Sirtuin 1
  • Stroke Volume

Keywords

  • chronic kidney disease
  • hemodialysis
  • sirtuin1
  • αKlotho


Small extracellular vesicles deliver miR-21 and miR-217 as pro-senescence effectors to endothelial cells.


Keywords

  • Cellular senescence
  • DNMT1
  • SIRT1
  • extracellular vesicles
  • microRNAs


Spatiotemporal gating of SIRT1 functions by O-GlcNAcylation is essential for liver metabolic switching and prevents hyperglycemia.


MeSH Terms

  • Acetylglucosamine
  • Aging
  • Animals
  • Fasting
  • Gluconeogenesis
  • Glycosylation
  • HEK293 Cells
  • Homeostasis
  • Humans
  • Hyperglycemia
  • Insulin Resistance
  • Liver
  • Male
  • Mice
  • Mice, Inbred C57BL
  • Obesity
  • Phosphorylation
  • Protein Processing, Post-Translational
  • Sirtuin 1
  • Spatio-Temporal Analysis

Keywords

  • PGC1α
  • fed–fast cycle
  • gluconeogenesis
  • insulin signaling
  • ubiquitinylation


Hydrogen Sulfide Inhibits Homocysteine-Induced Neuronal Senescence by Up-Regulation of SIRT1.


Keywords

  • SIRT1
  • cell senescence
  • homocysteine
  • hydrogen sulfide


SIRT1 and aging related signaling pathways.


Keywords

  • Aging
  • Deacetylate
  • NAD(+)
  • SIRT1
  • Signaling pathways


Tropisetron protects against brain aging via attenuating oxidative stress, apoptosis and inflammation: The role of SIRT1 signaling.


MeSH Terms

  • Aging
  • Animals
  • Antioxidants
  • Apoptosis
  • Brain
  • Drug Administration Schedule
  • Galactose
  • Gene Expression Regulation
  • Inflammation
  • Injections, Intraperitoneal
  • Injections, Subcutaneous
  • Interleukin-6
  • Male
  • Mice
  • Mitochondria
  • Neurons
  • Nitric Oxide
  • Oxidative Stress
  • Proto-Oncogene Proteins c-bcl-2
  • Reactive Oxygen Species
  • Serotonin 5-HT3 Receptor Antagonists
  • Sirtuin 1
  • Tropisetron
  • Tumor Necrosis Factor-alpha
  • bcl-2-Associated X Protein

Keywords

  • Aging
  • Brain
  • Neurotoxicity
  • Sirtuin 1
  • Tropisetron
  • d-galactose


Nicotinamide mononucleotide (NMN) supplementation promotes neurovascular rejuvenation in aged mice: transcriptional footprint of SIRT1 activation, mitochondrial protection, anti-inflammatory, and anti-apoptotic effects.


Keywords

  • Aging
  • Geroscience
  • Mitochondria dysfunction
  • Transcriptomics
  • Vascular cognitive impairment


Deacetylation of MRTF-A by SIRT1 defies senescence induced down-regulation of collagen type I in fibroblast cells.


MeSH Terms

  • Acetylation
  • Animals
  • Benzamides
  • Carbazoles
  • Cellular Senescence
  • Collagen Type I
  • Down-Regulation
  • Embryo, Mammalian
  • Fibroblasts
  • HEK293 Cells
  • Heterocyclic Compounds, 4 or More Rings
  • Humans
  • Mice
  • Mutation
  • Naphthols
  • Primary Cell Culture
  • Promoter Regions, Genetic
  • RNA, Small Interfering
  • Resveratrol
  • Sirtuin 1
  • Trans-Activators

Keywords

  • Collagen type I
  • Fibroblast
  • Lysine deacetylation
  • Post-translational modification
  • Senescence
  • Transcriptional regulation


Chronic Polyphenon-60 or Catechin Treatments Increase Brain Monoamines Syntheses and Hippocampal SIRT1 Levels Improving Cognition in Aged Rats.


MeSH Terms

  • Age Factors
  • Animals
  • Behavior, Animal
  • Biogenic Monoamines
  • Catechin
  • Cognition
  • Cognitive Aging
  • Corpus Striatum
  • Hippocampus
  • Male
  • Memory, Episodic
  • Memory, Short-Term
  • Neuroprotective Agents
  • Rats, Sprague-Dawley
  • Sirtuin 1
  • Time Factors

Keywords

  • NF-κB
  • RBAP46/48
  • SIRT1
  • brain aging
  • brain monoamine synthesis
  • catechin
  • green tea
  • memory


Duck Oil-loaded Nanoemulsion Inhibits Senescence of Angiotensin II-treated Vascular Smooth Muscle Cells by Upregulating SIRT1.


Keywords

  • SIRT1
  • angiotensin II
  • duck oil
  • nanoemulsion
  • senescence


Two novel SIRT1 activators, SCIC2 and SCIC2.1, enhance SIRT1-mediated effects in stress response and senescence.


Keywords

  • Sirtuins
  • drug discovery
  • epigenetic modulators
  • senescence
  • stress response


Hydrogen sulfide attenuates mitochondrial dysfunction-induced cellular senescence and apoptosis in alveolar epithelial cells by upregulating sirtuin 1.


MeSH Terms

  • A549 Cells
  • Alveolar Epithelial Cells
  • Apoptosis
  • Cellular Senescence
  • Humans
  • Hydrogen Sulfide
  • Mitochondria
  • Oxidative Stress
  • Sirtuin 1
  • Smoke
  • Tobacco
  • Up-Regulation

Keywords

  • alveolar epithelial cell
  • cigarette smoke extract
  • hydrogen sulfide
  • mitochondria injury
  • senescence


The protective role of omentin-1 in IL-1β-induced chondrocyte senescence.


MeSH Terms

  • Adipokines
  • Caveolin 1
  • Cell Line, Tumor
  • Cellular Senescence
  • Chondrocytes
  • Cyclin-Dependent Kinase Inhibitor p21
  • Cytoprotection
  • G1 Phase Cell Cycle Checkpoints
  • Humans
  • Interleukin-1beta
  • Plasminogen Activator Inhibitor 1
  • Sirtuin 1
  • Transcriptional Activation

Keywords

  • IL-1β
  • Omentin-1
  • SIRT-1
  • chondrocyte senescence


The Lifespan Extension Ability of Nicotinic Acid Depends on Whether the Intracellular NAD Level Is Lower than the Sirtuin-Saturating Concentrations.


MeSH Terms

  • Animals
  • Caenorhabditis elegans
  • Caenorhabditis elegans Proteins
  • Caloric Restriction
  • Cell Line
  • Humans
  • NAD
  • Niacin
  • Sirtuins
  • beta-Galactosidase

Keywords

  • C. elegans
  • Hs68 cells
  • NAD+
  • calorie restriction mimetic
  • lifespan
  • nicotinic acid


Alpha-mangostin decreased cellular senescence in human umbilical vein endothelial cells.


Keywords

  • Alpha-mangostin
  • Diabetes
  • HUVEC
  • High glucose
  • SIRT1
  • Senescence


Central nervous system SIRT1 expression is required for cued and contextual fear conditioning memory responses in aging mice.


Keywords

  • Fear conditioning
  • SIRT1
  • aging
  • classically conditioned memory
  • hippocampus


Does education level protect us from rapid ageing? Sirtuin expression versus age and level of education.


MeSH Terms

  • Adolescent
  • Adult
  • Age Factors
  • Aging
  • Aging, Premature
  • Educational Status
  • Epigenesis, Genetic
  • Female
  • Gene Expression Regulation, Enzymologic
  • Histones
  • Humans
  • Learning
  • Male
  • Middle Aged
  • Sirtuins
  • Young Adult


CO ameliorates endothelial senescence induced by 5-fluorouracil through SIRT1 activation.


MeSH Terms

  • Antioxidants
  • Carbon Monoxide
  • Cellular Senescence
  • Down-Regulation
  • Fluorouracil
  • Heme Oxygenase-1
  • Human Umbilical Vein Endothelial Cells
  • Humans
  • Nitric Oxide Synthase Type III
  • Reactive Oxygen Species
  • Sirtuin 1

Keywords

  • 5-Fluorouracil
  • Carbon monoxide
  • Endothelial senescence
  • Reactive oxygen species
  • SIRT1


Long noncoding RNA GAS5 inhibits cell proliferation and fibrosis in diabetic nephropathy by sponging miR-221 and modulating SIRT1 expression.


MeSH Terms

  • Aging
  • Animals
  • Argonaute Proteins
  • Cell Proliferation
  • Diabetes Mellitus, Experimental
  • Diabetic Nephropathies
  • Fibrosis
  • Gene Deletion
  • Gene Expression Regulation
  • Glucose
  • Male
  • Mesangial Cells
  • Mice
  • MicroRNAs
  • RAW 264.7 Cells
  • RNA, Long Noncoding
  • Rats
  • Rats, Sprague-Dawley
  • Sirtuin 1

Keywords

  • diabetic nephropathy
  • fibrosis
  • lncRNA GAS5
  • proliferation


The Role of Sirtuin1 in Regulating Endothelial Function, Arterial Remodeling and Vascular Aging.


Keywords

  • PVAT
  • SIRT1
  • eNOS
  • vascular aging
  • vascular remodeling


Deacetylation of LAMP1 drives lipophagy-dependent generation of free fatty acids by Abrus agglutinin to promote senescence in prostate cancer.


Keywords

  • Abrus agglutinin
  • LAMP1
  • SIRT1
  • free fatty acid
  • lipophagy
  • reactive oxygen species
  • senescence


Plasma exosomes in OSA patients promote endothelial senescence: effect of long-term adherent continuous positive airway pressure.


Keywords

  • CPAP
  • OSA
  • aging
  • cardiovascular
  • endothelium
  • exosomes
  • extracellular vesicles
  • intermittent hypoxia
  • oxidative stress
  • senescence


Hydrogen Sulfide Inhibits High Glucose-Induced Neuronal Senescence by Improving Autophagic Flux [i]via[/i] Up-regulation of SIRT1.


Keywords

  • SIRT1
  • autophagic flux
  • high glucose
  • hydrogen sulfide
  • neuronal senescence


Activation of the miR-34a-Mediated SIRT1/mTOR Signaling Pathway by Urolithin A Attenuates D-Galactose-Induced Brain Aging in Mice.


MeSH Terms

  • Aging
  • Animals
  • Brain
  • Coumarins
  • Galactose
  • Male
  • Mice
  • Mice, Inbred ICR
  • MicroRNAs
  • PC12 Cells
  • Random Allocation
  • Rats
  • Signal Transduction
  • Sirtuin 1
  • TOR Serine-Threonine Kinases

Keywords

  • D-Gal
  • SIRT1/mTOR signal pathway
  • Urolithin A
  • aging
  • autophagy
  • miR-34a

SIRT2[править]

Melatonin ameliorates the advanced maternal age-associated meiotic defects in oocytes through the SIRT2-dependent H4K16 deacetylation pathway.


Keywords

  • aging
  • histone acetylation
  • meiosis
  • melatonin
  • oocyte quality

SIRT3[править]

SIRT3 protects endothelial cells from high glucose-induced senescence and dysfunction via the p53 pathway.


Keywords

  • Endothelial senescence
  • High glucose
  • SIRT3
  • p53


Melatonin and Sirtuins in Buccal Epithelium: Potential Biomarkers of Aging and Age-Related Pathologies.


Keywords

  • aging
  • arterial hypertension
  • buccal epithelium
  • melatonin
  • sirtuins


[i]SIRT3[/i] Transfection of Aged Human Bone Marrow-Derived Mesenchymal Stem Cells Improves Cell Therapy-Mediated Myocardial Repair.


Keywords

  • O-hMSC transplantation
  • SIRT3
  • aging
  • gene modification
  • myocardial infarction
  • myocardial repair


17β-estradiol inhibits H O -induced senescence in HUVEC cells through upregulating SIRT3 expression and promoting autophagy.


Keywords

  • 17β-estradiol
  • Autophagy
  • SIRT3
  • Senescence


CR6 interacting factor 1 deficiency induces premature senescence via SIRT3 inhibition in endothelial cells.


Keywords

  • Antioxidant system
  • Mitochondria
  • Oxidative stress
  • Senescence
  • Vascular endothelial cell


Mitochondrial function in skeletal myofibers is controlled by a TRF2-SIRT3 axis over lifetime.


Keywords

  • aging
  • mitochondria
  • postmitotic cells
  • skeletal muscle
  • telomeres


Context-Dependent Roles for SIRT2 and SIRT3 in Tumor Development Upon Calorie Restriction or High Fat Diet.


Keywords

  • SIRT2
  • SIRT3
  • aging
  • calorie restriction
  • cancer
  • high fat diet


The yin and yang faces of the mitochondrial deacetylase sirtuin 3 in age-related disorders.


MeSH Terms

  • Aging
  • Animals
  • Cardiovascular Diseases
  • Humans
  • Metabolic Diseases
  • Mitochondria
  • Neurodegenerative Diseases
  • Protein Isoforms
  • Sirtuin 3

Keywords

  • Age-related diseases
  • Deacetylation
  • Genetic manipulations
  • Mitochondria
  • Pharmacological modulators
  • Sirtuins

SIRT5[править]

Lysine malonylation and propionylation are prevalent in human lens proteins.


MeSH Terms

  • Aging
  • Animals
  • Blotting, Western
  • Chromatography, Liquid
  • Crystallins
  • Cytoskeletal Proteins
  • Cytosol
  • Epithelial Cells
  • Humans
  • Immunohistochemistry
  • Lens, Crystalline
  • Lysine
  • Malonates
  • Membrane Proteins
  • Mice, Inbred C57BL
  • Mice, Knockout
  • Middle Aged
  • Mitochondrial Proteins
  • Organ Culture Techniques
  • Paraffin Embedding
  • Propionates
  • Sirtuin 3
  • Sirtuins
  • Tandem Mass Spectrometry

Keywords

  • Lens proteins
  • Malonylation
  • Mass spectrometry
  • Propionylation
  • Sirtuins

SIRT6[править]

Association between SIRT6 Methylation and Human Longevity in a Chinese Population.


Keywords

  • DNA Methylation
  • Longevity
  • Messenger RNA
  • SIRT6


The SIRT6 activator MDL-800 improves genomic stability and pluripotency of old murine-derived iPS cells.


Keywords

  • DNA repair
  • MDL-800
  • SIRT6
  • aging
  • genome integrity
  • pluripotency


Sirtuins as Possible Predictors of Aging and Alzheimer's Disease Development: Verification in the Hippocampus and Saliva.


Keywords

  • Alzheimer’s disease
  • aging
  • intravital diagnosis
  • saliva
  • sirtuins


Age-related epigenetic drift deregulates [i]SIRT6[/i] expression and affects its downstream genes in human peripheral blood mononuclear cells.


Keywords

  • SIRT6
  • aging
  • interaction network
  • longevity
  • methylation
  • miRNA
  • peripheral blood mononuclear cells (PBMCs)


Biological and catalytic functions of sirtuin 6 as targets for small-molecule modulators.


Keywords

  • SIRT6
  • activator
  • aging
  • cancer
  • cell metabolism
  • chromatin
  • gene expression
  • histone deacetylase (HDAC)
  • longevity
  • metabolic disorder
  • sirtuin
  • small molecule


Age-dependent role of SIRT6 in jawbone via regulating senescence and autophagy of bone marrow stromal cells.


MeSH Terms

  • Adult
  • Aged
  • Aging
  • Animals
  • Bone Marrow Cells
  • Humans
  • Jaw
  • Male
  • Mesenchymal Stem Cells
  • Mice
  • Mice, Knockout
  • Middle Aged
  • Osteogenesis
  • Sirtuins

Keywords

  • Autophagy
  • Bone marrow stromal cells
  • Jawbone
  • Osteoporosis
  • SIRT6
  • Senescence


Mechanism of activation for the sirtuin 6 protein deacylase.


MeSH Terms

  • Allosteric Regulation
  • Biocatalysis
  • Fatty Acids
  • HEK293 Cells
  • Histones
  • Humans
  • Hydrophobic and Hydrophilic Interactions
  • Kinetics
  • Lipids
  • Mutagenesis
  • Mutation
  • NAD
  • Peptides
  • Protein Binding
  • Protein Conformation
  • Sirtuins
  • Small Molecule Libraries

Keywords

  • SIRT6
  • activator
  • cancer
  • chromatin
  • deacetylation
  • epigenetics
  • histone
  • histone deacetylase (HDAC)
  • lifespan
  • long chain acyl substrate
  • longevity
  • sirtuin


Proteomics of Long-Lived Mammals.


Keywords

  • SIRT6
  • aging
  • long-lived mammals
  • naked mole rats
  • proteomics


Sirtuins and SIRT6 in Carcinogenesis and in Diet.


MeSH Terms

  • Aging
  • Animals
  • Carcinogenesis
  • Diet
  • Gene Expression Regulation, Neoplastic
  • Humans
  • Nanomedicine
  • Organ Specificity
  • Sirtuins

Keywords

  • SIRT6
  • cancer
  • chemotherapy
  • diet
  • modulator
  • sirtuins


SIRT6-mediated transcriptional suppression of MALAT1 is a key mechanism for endothelial to mesenchymal transition.


MeSH Terms

  • Aging
  • Animals
  • Cells, Cultured
  • Disease Models, Animal
  • Endothelium, Vascular
  • Epithelial-Mesenchymal Transition
  • Gene Expression Regulation
  • Male
  • Mice
  • Mice, Inbred C57BL
  • Mice, Knockout
  • RNA, Long Noncoding
  • Signal Transduction
  • Sirtuins
  • Vascular Diseases

SIRT7[править]

SIRT7 antagonizes human stem cell aging as a heterochromatin stabilizer.


Keywords

  • LINE1
  • SIRT7
  • STING
  • aging
  • cGAS
  • stem cell

SLA[править]

Vaccination of aged mice with adjuvanted recombinant influenza nucleoprotein enhances protective immunity.


Keywords

  • Adjuvant
  • Aging
  • Influenza
  • Mouse
  • Nucleoprotein
  • Vaccination


Mechanical Anisotropy and Surface Roughness in Additively Manufactured Parts Fabricated by Stereolithography (SLA) Using Statistical Analysis.


Keywords

  • Taguchi methods
  • additive manufacturing
  • aging effect
  • analysis of variance
  • anisotropy
  • design of experiments
  • stereolithography
  • surface roughness
  • tensile testing


The Effect of Age of Titanium Dental Implants on Implant Survival and Marginal Bone Resorption: A 5-Year Retrospective Follow-Up Study.


Keywords 

           aged implant
         
       

           biological aging
         
       

           implant survival
         
       

           marginal bone resorption
         
       

           titanium dental implant

SLC16A7[править]

Genetics of facial telangiectasia in the Rotterdam Study: a genome-wide association study and candidate gene approach.


Keywords

  • GWAS
  • KIAA0930
  • MC1R
  • SLCA45A2
  • SNP
  • Telangiectasia
  • candidate gene approach
  • epidemiology
  • genetics
  • pigmentation genes
  • red veins
  • skin aging

SLC26A2[править]

Phenotypic characterization of Slc26a2 mutant mice reveals a multifactorial etiology of spondylolysis.


MeSH Terms

  • Aging
  • Animals
  • Lumbar Vertebrae
  • Male
  • Mice
  • Osteogenesis
  • Phenotype
  • Spondylolysis
  • Sulfate Transporters

Keywords

  • SLC26A2
  • bone loss
  • isthmic defect
  • spondylolysis
  • vertebral development

SLC6A4[править]

The Psilocybin-Telomere Hypothesis: An empirically falsifiable prediction concerning the beneficial neuropsychopharmacological effects of psilocybin on genetic aging.


MeSH Terms

  • Aging
  • Aging, Premature
  • Animals
  • Anxiety
  • Brain-Derived Neurotrophic Factor
  • Consciousness
  • DNA Methylation
  • Depression
  • Disease Models, Animal
  • Endocrine System
  • Humans
  • Models, Genetic
  • Models, Psychological
  • Neurotransmitter Agents
  • Oxidative Stress
  • Personality
  • Psilocybin
  • Psychotropic Drugs
  • Research Design
  • Serotonin Plasma Membrane Transport Proteins
  • Stress, Psychological
  • Telomere Shortening

Keywords

  • Cellular senescence
  • Depression
  • Epigenetic clock
  • Genetic aging
  • Life extension
  • Neurophenomenology
  • Psilocybin
  • Rejuvenation
  • Rumination
  • Senotherapy
  • Telomeres

SMAD1[править]

TGFB1-Mediated Gliosis in Multiple Sclerosis Spinal Cords Is Favored by the Regionalized Expression of HOXA5 and the Age-Dependent Decline in Androgen Receptor Ligands.


MeSH Terms

  • Age Factors
  • Aged
  • Aging
  • Brain
  • Data Mining
  • Databases, Genetic
  • Disease Progression
  • Female
  • Gene Expression Profiling
  • Gliosis
  • Homeodomain Proteins
  • Humans
  • Ligands
  • Male
  • Middle Aged
  • Multiple Sclerosis
  • Proteomics
  • Receptors, Androgen
  • Sequence Analysis, RNA
  • Signal Transduction
  • Smad1 Protein
  • Spinal Cord
  • Transforming Growth Factor beta1
  • Up-Regulation

Keywords

  • androgen receptor
  • astrocytes
  • homeobox A5
  • multiple sclerosis
  • spinal cord
  • transforming growth factor beta 1

SMAD2[править]

Prostate epithelial-specific expression of activated PI3K drives stromal collagen production and accumulation.


MeSH Terms

  • Aging
  • Animals
  • Class I Phosphatidylinositol 3-Kinases
  • Collagen
  • Disease Models, Animal
  • Disease Progression
  • Epithelium
  • Male
  • Mice, Mutant Strains
  • Phosphorylation
  • Prostate
  • Prostatic Hyperplasia
  • Prostatic Intraepithelial Neoplasia
  • Prostatic Neoplasms
  • Signal Transduction
  • Smad2 Protein
  • Stromal Cells
  • Transforming Growth Factor beta

Keywords

  • PIK3CA
  • cancer
  • collagen
  • fibrosis
  • mouse model
  • prostate
  • stroma

SMAD3[править]

Sirtuin 6 deficiency transcriptionally up-regulates TGF-β signaling and induces fibrosis in mice.


MeSH Terms

  • Aging
  • Animals
  • Fibroblasts
  • Fibrosis
  • Gene Deletion
  • Male
  • Mice
  • Myocardium
  • Myofibroblasts
  • Signal Transduction
  • Sirtuins
  • Smad3 Protein
  • Transcriptional Activation
  • Transforming Growth Factor beta

Keywords

  • SIRT6 deacetylase
  • SMAD transcription factor
  • SMAD3
  • TGF-beta signaling
  • aging
  • aging-associated fibrosis
  • caloric restriction
  • cardiac disease
  • extracellular matrix (ECM)
  • fibrosis
  • sirtuin
  • transforming growth factor beta (TGF-beta)

SMN2[править]

Age-dependent SMN expression in disease-relevant tissue and implications for SMA treatment.


MeSH Terms

  • Aging
  • Autopsy
  • Cell Survival
  • Female
  • Humans
  • Male
  • Motor Neurons
  • Muscular Atrophy, Spinal
  • Oligodeoxyribonucleotides, Antisense
  • Spinal Cord
  • Survival of Motor Neuron 2 Protein

Keywords

  • Development
  • Neurodegeneration
  • Neurodevelopment
  • Neuromuscular disease
  • Neuroscience

SMS[править]

Does a Live Performance Impact Synchronization to Musical Rhythm in Cognitively Impaired Elderly?


Keywords

  • Aging
  • Alzheimer’s disease
  • cognitive impairment
  • dementia
  • motor activity
  • music therapy
  • social interaction


Testing the effectiveness of physical activity advice delivered via text messaging vs. human phone advisors in a Latino population: The On The Move randomized controlled trial design and methods.


Keywords

  • Aging
  • Digital health
  • Latino
  • Physical activity
  • Text-messaging
  • mHealth

SNAP25[править]

The Biological Foundations of Sarcopenia: Established and Promising Markers.


Keywords

  • SNAP25
  • aging
  • biomarkers
  • neuromuscular junction
  • sarcopenia

SNCA[править]

Behavioural and dopaminergic changes in double mutated human A30P*A53T alpha-synuclein transgenic mouse model of Parkinson´s disease.


MeSH Terms

  • Aging
  • Alanine
  • Amino Acid Substitution
  • Animals
  • Behavior, Animal
  • Disease Models, Animal
  • Dopaminergic Neurons
  • Humans
  • Locomotion
  • Male
  • Mice
  • Mice, Inbred C57BL
  • Mice, Transgenic
  • Mutation, Missense
  • Parkinson Disease
  • Proline
  • Threonine
  • alpha-Synuclein

SND1[править]

[Downregulation of SND1 Expression Accelerates Cell Senescence of Human Diploid Fibroblasts 2BS via Modulating the SASP].


MeSH Terms

  • Cellular Senescence
  • Diploidy
  • Down-Regulation
  • Endonucleases
  • Fibroblasts
  • Humans
  • Nuclear Proteins

Keywords

  • Aging
  • Cellular senescent
  • SND1
  • Senescence-associated-secretory-phenotype

SOD1[править]

SOD1, more than just an antioxidant.


Keywords

  • Aging
  • Cancer
  • Neurodegenerative diseases
  • Post-translational modifications
  • Superoxide dismutase 1


The Exacerbation of Aging and Oxidative Stress in the Epididymis of [i]Sod1[/i] Null Mice.


Keywords

  • 4-hydroxynonenal
  • 8-hydroxyguanosine
  • aging
  • epididymis
  • oxidative stress
  • reactive oxygen species
  • spermatozoa
  • superoxide dismutase


Alterations in lipid metabolism of spinal cord linked to amyotrophic lateral sclerosis.


MeSH Terms

  • Aging
  • Amyotrophic Lateral Sclerosis
  • Animals
  • Cardiolipins
  • Cholesterol Esters
  • Disease Models, Animal
  • Disease Progression
  • Fatty Acids, Unsaturated
  • Female
  • Humans
  • Lipid Droplets
  • Lipid Metabolism
  • Lipidomics
  • Male
  • Mass Spectrometry
  • Motor Cortex
  • Motor Neurons
  • Mutation
  • Oxidative Stress
  • Rats
  • Rats, Transgenic
  • Spinal Cord
  • Superoxide Dismutase-1

SOD2[править]

Astaxanthin Counteracts Vascular Calcification In Vitro Through an Early Up-Regulation of SOD2 Based on a Transcriptomic Approach.


Keywords

  • aortic calcification
  • astaxanthin
  • chronic kidney disease
  • chronic kidney disease-mineral bone disorder
  • oxidative stress
  • reactive oxygen species
  • senescence
  • vascular calcification
  • vascular smooth muscle cells


Alginate Oligosaccharide Prevents against D-galactose-mediated Cataract in C57BL/6J Mice via Regulating Oxidative Stress and Antioxidant System.


Keywords

  • Cataract
  • D-galactose
  • aging
  • alginate oligosaccharide
  • oxidative stress


Protoflavones in melanoma therapy: Prooxidant and pro-senescence effect of protoapigenone and its synthetic alkyl derivative in A375 cells.


MeSH Terms

  • Antineoplastic Agents, Phytogenic
  • Autophagy
  • Biomarkers
  • Cell Cycle
  • Cell Line, Tumor
  • Cellular Senescence
  • Cyclohexanones
  • Flavones
  • Humans
  • Melanoma
  • Reactive Oxygen Species
  • Superoxide Dismutase
  • beta-Galactosidase

Keywords

  • Alkyl protoflavone
  • Flavonoid
  • Melanoma
  • Protoapigenone
  • Semi-synthesis
  • Senescence


Ginsenoside Rg1 protects against Sca-1 HSC/HPC cell aging by regulating the SIRT1-FOXO3 and SIRT3-SOD2 signaling pathways in a γ-ray irradiation-induced aging mice model.


Keywords

  • SIRT1
  • SIRT3
  • aging
  • ginsenoside Rg1
  • hematopoietic progenitor cells
  • hematopoietic stem cells
  • senescence
  • γ-ray irradiation


Almond Skin Extracts and Chlorogenic Acid Delay Chronological Aging and Enhanced Oxidative Stress Response in Yeast.


Keywords

  • 8-Oxo-guanine
  • aging
  • almond
  • chlorogenic acid
  • lipid peroxidation
  • mitochondria
  • oxidative stress
  • protein carbonylation
  • sirtuin
  • superoxide dismutase
  • yeast


Opposing p53 and mTOR/AKT promote an in vivo switch from apoptosis to senescence upon telomere shortening in zebrafish.


Keywords

  • AKT
  • aging
  • apoptosis
  • cell biology
  • p53
  • regenerative medicine
  • senescence
  • stem cells
  • telomeres
  • zebrafish


Bioactive peptides derived from crimson snapper and in vivo anti-aging effects on fat diet-induced high fat Drosophila melanogaster.


MeSH Terms

  • Aging
  • Animal Scales
  • Animals
  • Catalase
  • Diet, High-Fat
  • Disease Models, Animal
  • Drosophila Proteins
  • Drosophila melanogaster
  • Female
  • Fish Proteins
  • Fishes
  • Humans
  • Longevity
  • Male
  • Malondialdehyde
  • Oxidative Stress
  • Peptides
  • Superoxide Dismutase


Ellagic acid prolongs the lifespan of Drosophila melanogaster.


Keywords

  • Drosophila melanogaster
  • Ellagic acid
  • Gene expression
  • Longevity
  • Stress


Chlorella vulgaris modulates the expression of senescence-associated genes in replicative senescence of human diploid fibroblasts.


MeSH Terms

  • Antioxidants
  • Catalase
  • Cell Differentiation
  • Cell Proliferation
  • Cells, Cultured
  • Cellular Senescence
  • Chlorella vulgaris
  • DNA Damage
  • Diploidy
  • Fibroblasts
  • Gene Expression
  • Genes, p53
  • Humans
  • Male
  • Mitogen-Activated Protein Kinase 14
  • Molecular Chaperones
  • Primary Cell Culture
  • Signal Transduction
  • Superoxide Dismutase
  • Superoxide Dismutase-1

Keywords

  • Chlorella vulgaris
  • Fibroblasts
  • Replicative senescence
  • Senescence-associated genes


Age-Associated Changes in Antioxidants and Redox Proteins of Rat Heart.


MeSH Terms

  • Aging
  • Animals
  • Antioxidants
  • Glutathione Peroxidase
  • Male
  • Myocardium
  • Oxidation-Reduction
  • Rats
  • Rats, Wistar
  • Superoxide Dismutase


Impact of curcumin on replicative and chronological aging in the Saccharomyces cerevisiae yeast.


Keywords

  • Aging
  • Curcumin
  • Hypertrophy
  • Oxidative stress
  • Yeast

SOX13[править]

In silico analysis of human renin gene-gene interactions and neighborhood topologically associated domains suggests breakdown of insulators contribute to ageing-associated diseases.


MeSH Terms

  • Aging
  • Computer Simulation
  • Epistasis, Genetic
  • Humans
  • Promoter Regions, Genetic
  • Renin

Keywords

  • Aging
  • Diseases of aging
  • Gene expression
  • Gene–gene interaction
  • Genomics
  • Longevity
  • Renin-angiotensin system
  • Topologically associated domains

SOX2[править]

Multiple nanosecond pulsed electric fields stimulation with conductive poly(l-lactic acid)/carbon nanotubes films maintains the multipotency of mesenchymal stem cells during prolonged in vitro culture.


Keywords

  • cell physical stimulus
  • differentiation
  • mesenchymal stem cells
  • multipotency
  • nanosecond pulsed electric fields
  • senescence


Subpopulations of miniature pig mesenchymal stromal cells with different differentiation potentials differ in the expression of octamer-binding transcription factor 4 and sex determining region Y-box 2.


Keywords

  • Aging
  • Mesenchymal Stromal Cell (MSC) Subpopulations
  • Miniature Pig
  • Octamerbinding Transcription Factor 4 (OCT4)
  • Sex Determining Region Y-box 2 (SOX2)


Increased Type I and Decreased Type II Hair Cells after Deletion of Sox2 in the Developing Mouse Utricle.


MeSH Terms

  • Aging
  • Animals
  • Cell Count
  • Cell Differentiation
  • Cell Lineage
  • Hair Cells, Vestibular
  • Mice
  • Mice, Knockout
  • Mice, Transgenic
  • SOXB1 Transcription Factors
  • Saccule and Utricle

Keywords

  • SOX2
  • balance disorder
  • hair cell
  • utricle
  • vestibule

SOX4[править]

Age-induced accumulation of methylmalonic acid promotes tumour progression.


MeSH Terms

  • Adult
  • Aged
  • Aging
  • Animals
  • Cell Line, Tumor
  • Disease Progression
  • Female
  • Gene Expression Regulation, Neoplastic
  • Humans
  • Male
  • Methylmalonic Acid
  • Mice
  • Middle Aged
  • Neoplasm Invasiveness
  • Neoplasm Metastasis
  • Neoplasms
  • SOXC Transcription Factors
  • Signal Transduction
  • Transcriptome
  • Transforming Growth Factor beta

SOX9[править]

Positive Effects of a Young Systemic Environment and High Growth Differentiation Factor 11 Levels on Chondrocyte Proliferation and Cartilage Matrix Synthesis in Old Mice.


MeSH Terms

  • Adolescent
  • Aged
  • Aging
  • Animals
  • Arthroplasty, Replacement, Knee
  • Bone Morphogenetic Proteins
  • Cartilage, Articular
  • Cell Proliferation
  • Chondrocytes
  • Collagen Type II
  • Collagen Type X
  • Core Binding Factor Alpha 1 Subunit
  • Extracellular Matrix
  • Female
  • Growth Differentiation Factors
  • Humans
  • In Vitro Techniques
  • Knee Joint
  • Male
  • Matrix Metalloproteinase 13
  • Mice
  • Osteoarthritis, Knee
  • Parabiosis
  • Phosphorylation
  • RNA, Messenger
  • Reverse Transcriptase Polymerase Chain Reaction
  • SOX9 Transcription Factor
  • Smad2 Protein
  • Smad3 Protein
  • Stifle
  • Young Adult

SPARC[править]

SPARC Metrics Provide Mobility Smoothness Assessment in Oldest-Old With and Without a History of Falls: A Case Control Study.


Keywords

  • aging
  • falls
  • functional mobility
  • movement smoothness
  • oldest-old


Reduced fibrillar collagen accumulation in skeletal muscle of secreted protein acidic and rich in cysteine (SPARC)-null mice.


MeSH Terms

  • Aging
  • Animals
  • Fibrillar Collagens
  • Gene Expression
  • Male
  • Mice
  • Mice, Knockout
  • Muscle, Skeletal
  • Myofibrils
  • Osteonectin

Keywords

  • Secreted protein acidic and rich in cysteine
  • collagen
  • fibrosis
  • myofiber
  • skeletal muscle

SPR[править]

Regulation of lifespan by neural excitation and REST.


MeSH Terms

  • Aging
  • Animals
  • Brain
  • Caenorhabditis elegans
  • Caenorhabditis elegans Proteins
  • DNA-Binding Proteins
  • Forkhead Transcription Factors
  • Humans
  • Longevity
  • Mice
  • Mice, 129 Strain
  • Mice, Inbred C57BL
  • Mice, Knockout
  • Mice, Transgenic
  • Neurons
  • RNA Interference
  • RNA-Binding Proteins
  • Repressor Proteins
  • Transcription Factors

SPRTN[править]

Tandem Deubiquitination and Acetylation of SPRTN Promotes DNA-Protein Crosslink Repair and Protects against Aging.


MeSH Terms

  • Acetylation
  • Aging
  • Animals
  • Cell Line
  • DNA Damage
  • DNA Repair
  • DNA-Binding Proteins
  • Deubiquitinating Enzymes
  • Endopeptidases
  • Female
  • Genomic Instability
  • HEK293 Cells
  • Humans
  • Male
  • Mice, Inbred C57BL
  • Mice, Knockout
  • Phosphorylation
  • Protein Domains
  • Protein Processing, Post-Translational
  • Ubiquitination

Keywords

  • DNA repair
  • DNA-protein crosslink
  • SPRTN
  • Top1cc
  • VCPIP1/VCIP135
  • acetylation
  • aging
  • genomic instability
  • metalloprotease
  • ubiquitination

SPRY1[править]

Sprouty1 Prevents Cellular Senescence Maintaining Proliferation and Differentiation Capacity of Human Adipose Stem/Progenitor Cells.


Keywords

  • Adipogenesis
  • Adipose stem cell
  • Obesity
  • Senescence
  • Sprouty1


Mechanism of SPRY1 methylation regulating natural aging of skin epidermal cells.


Keywords

  • SPRY1
  • methylation
  • natural aging
  • skin epidermal aging

SQSTM1[править]

The selective autophagy receptor SQSTM1/p62 improves lifespan and proteostasis in an evolutionarily conserved manner.


Keywords

  • Aging
  • C. elegans
  • Drosophila
  • SQST-1
  • SQSTM1
  • aggrephagy
  • heat shock
  • mitophagy
  • p62
  • proteostasis
  • ref(2)P
  • selective autophagy

SRC[править]

Metabolic characteristics of CD8 T cell subsets in young and aged individuals are not predictive of functionality.


MeSH Terms

  • Adult
  • Aged
  • Aging
  • Animals
  • CD8-Positive T-Lymphocytes
  • Cell Differentiation
  • Cell Proliferation
  • Disease Models, Animal
  • Female
  • Humans
  • Immunologic Memory
  • Influenza A virus
  • Influenza, Human
  • Male
  • Mice
  • Microscopy, Electron, Transmission
  • Mitochondria
  • T-Lymphocyte Subsets
  • Young Adult

SRD5A2[править]

Extract of Plumbago zeylanica enhances the growth of hair follicle dermal papilla cells with down-regulation of 5α-reductase type II.


Keywords

P zeylanica

  • 5α-reductase
  • dermal papilla
  • hair
  • plumbagin
  • senescence

SRF[править]

Changes in snail and SRF expression in the kidneys of diabetic rats during ageing.


MeSH Terms

  • Aging
  • Animals
  • Diabetes Mellitus, Experimental
  • Diabetic Nephropathies
  • Gene Expression Regulation
  • Kidney
  • Male
  • Rats
  • Rats, Sprague-Dawley
  • Snail Family Transcription Factors
  • Transcription Factors

Keywords

  • Diabetic nephropathy
  • Renal fibrosis
  • SRF
  • Snail


Mechanosensitive transcriptional coactivators MRTF-A and YAP/TAZ regulate nucleus pulposus cell phenotype through cell shape.


MeSH Terms

  • Actins
  • Adaptor Proteins, Signal Transducing
  • Aging
  • Biomechanical Phenomena
  • Cells, Cultured
  • Cytoskeleton
  • Gene Expression Regulation
  • Humans
  • Hydrogels
  • Intervertebral Disc Degeneration
  • Nucleus Pulposus
  • RNA Interference
  • Trans-Activators
  • Transcription Factors
  • rho-Associated Kinases

Keywords

  • F-actin
  • SRF
  • TEAD
  • intervertebral disc
  • mechanotransduction

SRL[править]

Income dividends and subjective survival in a Cherokee Indian cohort: a quasi-experiment.


MeSH Terms

  • Adult
  • Aged
  • Aged, 80 and over
  • Cohort Studies
  • Female
  • Humans
  • Income
  • Indians, South American
  • Longevity
  • Male
  • Middle Aged
  • North Carolina
  • Social Class
  • Surveys and Questionnaires
  • Survival Analysis

SRM[править]

[Geriatric specificities of localized renal cell carcinoma].


MeSH Terms

  • Age Factors
  • Aged
  • Carcinoma, Renal Cell
  • Geriatric Assessment
  • Humans
  • Kidney Neoplasms

Keywords

  • Cancer du rein
  • Diagnosis
  • Diagnostic
  • Elderly
  • Geriatrics
  • Gériatrie
  • Personne âgée
  • Petite masse rénale
  • Renal cell carcinoma
  • Small renal mass
  • Traitement
  • Treatment

SSB[править]

Modelling the Effects of Beverage Substitution during Adolescence on Later Obesity Outcomes in Early Adulthood: Results from the Raine Study.


MeSH Terms

  • Adolescent
  • Adolescent Nutritional Physiological Phenomena
  • Aging
  • Humans
  • Models, Biological
  • Obesity
  • Odds Ratio
  • Risk Factors
  • Sugar-Sweetened Beverages
  • Young Adult

Keywords

  • obesity
  • substitution modelling
  • sugar-sweetened beverages
  • waist circumference

SST[править]

The distance to death perceptions of older adults explain why they age in place: A theoretical examination.


Keywords

  • Agency- or belonging-related
  • Distance to death, aging in place
  • Emotions
  • Residential mobility
  • Socioemotional selectivity theory


Population Segmentation Based on Healthcare Needs: Validation of a Brief Clinician-Administered Tool.


Keywords

  • aging
  • health services research
  • psychometrics


Examination on how emotion regulation mediates the relationship between future time perspective and well-being: a counter-evidence to the socioemotional selectivity theory.


Keywords

  • Aging
  • Emotion regulation
  • Future time perspective
  • Socioemotional selectivity theory
  • Time left in life

STAT1[править]

STAT1-p53-p21axis-dependent stress-induced progression of chronic nephrosis in adriamycin-induced mouse model.


Keywords

  • Adriamycin
  • STAT1
  • chronic nephrosis (CN)
  • mitogen-activated protein kinase
  • senescence


Age-Dependent and -Independent Effects of Perivascular Adipose Tissue and Its Paracrine Activities during Neointima Formation.


MeSH Terms

  • Adipose Tissue
  • Aging
  • Animals
  • Carotid Arteries
  • Carotid Artery Diseases
  • Carotid Artery Injuries
  • Humans
  • Mice
  • Mice, Mutant Strains
  • Neointima
  • Paracrine Communication
  • STAT1 Transcription Factor

Keywords

  • aging
  • atherosclerosis
  • neointima formation
  • perivascular adipose tissue


Legumain-deficient macrophages promote senescence of tumor cells by sustaining JAK1/STAT1 activation.


MeSH Terms

  • Animals
  • Bone Marrow Transplantation
  • Breast Neoplasms
  • Cell Cycle Proteins
  • Cell Line, Tumor
  • Cellular Senescence
  • Disease Models, Animal
  • Female
  • Gene Expression Regulation, Neoplastic
  • Humans
  • Integrin alphaVbeta3
  • Interleukin-1beta
  • Janus Kinase 1
  • Macrophage Activation
  • Macrophages
  • Mice
  • Mice, Knockout
  • STAT1 Transcription Factor
  • Signal Transduction

Keywords

  • Cellular senescence
  • Legumain
  • M1 polarization
  • Tumor-associated macrophage

STAT3[править]

Dietary Restriction Suppresses Steatosis-Associated Hepatic Tumorigenesis in Hepatitis C Virus Core Gene Transgenic Mice.


Keywords

  • Cyclin D1
  • NF-κB
  • STAT3
  • Senescence
  • p62/SQSTM1


Skeletal glucocorticoid signalling determines leptin resistance and obesity in aging mice.


Keywords

  • Aging
  • Appetite
  • Glucocorticoid
  • Leptin
  • Obesity
  • Osteoblast
  • Osteocyte


AMPK alleviates oxidative stress‑induced premature senescence via inhibition of NF-κB/STAT3 axis-mediated positive feedback loop.


Keywords

  • AMPK
  • NF-κB/STAT3 signalling
  • Oxidative stress
  • SASP
  • Senescence


Age-related loss of neural stem cell O-GlcNAc promotes a glial fate switch through STAT3 activation.


MeSH Terms

  • Aging
  • Animals
  • Cell Differentiation
  • Cell Proliferation
  • Computational Biology
  • Gene Expression Regulation
  • Glucosamine
  • Hippocampus
  • Mice
  • Neural Stem Cells
  • Neurogenesis
  • Neuroglia
  • STAT3 Transcription Factor
  • Sequence Analysis, RNA

Keywords

  • O-GlcNAcylation
  • aging
  • gliogenesis
  • neural stem cells
  • neurogenesis


Cell Death by Gallotannin Is Associated with Inhibition of the JAK/STAT Pathway in Human Colon Cancer Cells.


Keywords

  • Apoptosis
  • JAK/STAT
  • caspase
  • colon cancer
  • gallotannin
  • senescence


The effect of interleukin 6 deficiency on myocardial signal transduction pathways activation induced by bacterial lipopolysaccharide in young and old mice.


Keywords

  • Aging
  • For review: bacterial lipolisacharide (LPS)
  • Heart
  • Inflammation
  • Interleukin-6
  • Signal transduction


Silibinin and SARS-CoV-2: Dual Targeting of Host Cytokine Storm and Virus Replication Machinery for Clinical Management of COVID-19 Patients.


Keywords

  • IL-6
  • JAK
  • coronavirus
  • cytokine storm
  • remdesivir
  • senescence
  • stat3


Implication of JAK1/STAT3/SOCS3 Pathway in Aging of Cerebellum of Male Rat: Histological and Molecular study.


MeSH Terms

  • Aging
  • Animals
  • Caspase 3
  • Cerebellum
  • Glial Fibrillary Acidic Protein
  • Glutathione
  • Immunohistochemistry
  • Janus Kinase 1
  • Male
  • Malondialdehyde
  • Microscopy, Electron
  • Rats
  • Rats, Wistar
  • STAT3 Transcription Factor
  • Signal Transduction
  • Suppressor of Cytokine Signaling 3 Protein
  • Tumor Necrosis Factor-alpha


Atorvastatin-induced senescence of hepatocellular carcinoma is mediated by downregulation of hTERT through the suppression of the IL-6/STAT3 pathway.


Keywords

  • Cancer therapy
  • Senescence


Deciphering the Molecular Mechanism of Spontaneous Senescence in Primary Epithelial Ovarian Cancer Cells.


Keywords

  • aging biomarkers
  • cancer biology
  • cellular senescence
  • epithelial ovarian cancer
  • oxidative stress


Persistent Activation of STAT3 Pathway in the Retina Induced Vision Impairment and Retinal Degenerative Changes in Ageing Mice.


MeSH Terms

  • Aging
  • Animals
  • Mice
  • Mice, Inbred C57BL
  • Retina
  • Retinal Degeneration
  • STAT3 Transcription Factor
  • Suppressor of Cytokine Signaling 3 Protein
  • Suppressor of Cytokine Signaling Proteins
  • Uveitis

Keywords

  • EAU
  • Experimental autoimmune uveitis
  • Retinal dystrophies
  • SOCS3
  • STAT3
  • Transgenic mouse
  • Uveitis


Interleukin-10 induces senescence of activated hepatic stellate cells via STAT3-p53 pathway to attenuate liver fibrosis.


Keywords

  • Hepatic stellate cells
  • Interleukin-10
  • Liver fibrosis
  • Senescence
  • Signal pathway

STC2[править]

Genome-wide Associations Reveal Human-Mouse Genetic Convergence and Modifiers of Myogenesis, CPNE1 and STC2.


MeSH Terms

  • Adult
  • Aged
  • Aging
  • Animals
  • Body Composition
  • Body Weight
  • Calcium-Binding Proteins
  • Case-Control Studies
  • Female
  • Follow-Up Studies
  • Genome-Wide Association Study
  • Glycoproteins
  • Humans
  • Intercellular Signaling Peptides and Proteins
  • Male
  • Mice
  • Middle Aged
  • Muscle Development
  • Muscle, Skeletal
  • Quantitative Trait Loci
  • Thinness

Keywords

  • UK Biobank
  • human and mouse GWAS
  • sarcopenia
  • skeletal muscle

STIM1[править]

Progerin in muscle leads to thermogenic and metabolic defects via impaired calcium homeostasis.


MeSH Terms

  • Animals
  • Calcium
  • Calnexin
  • Cell Nucleus
  • Disease Models, Animal
  • Endoplasmic Reticulum
  • Endoplasmic Reticulum Stress
  • Lamin Type A
  • Mice
  • Mice, Knockout
  • Microscopy, Electron, Transmission
  • Muscle Proteins
  • Muscle, Skeletal
  • Muscular Dystrophies
  • Mutation
  • Myoblasts
  • ORAI1 Protein
  • Progeria
  • Proteolipids
  • Stromal Interaction Molecule 1
  • Thermogenesis
  • Up-Regulation

Keywords

  • aging
  • calcium homeostasis
  • lamin A
  • muscular dystrophy
  • progeria

STS[править]

Delayed Impairment of Postural, Physical, and Muscular Functions Following Downhill Compared to Level Walking in Older People.


Keywords

  • aging
  • balance
  • falls
  • fatigue
  • functional performance
  • muscle damage
  • walking


Autophagy displays divergent roles during intermittent amino acid starvation and toxic stress-induced senescence in cultured skeletal muscle cells.


Keywords

  • autophagy
  • caspase
  • cell death
  • remodeling
  • senescence


The WRKY53 transcription factor enhances stilbene synthesis and disease resistance by interacting with MYB14 and MYB15 in Chinese wild grape.


Keywords

  • Chinese wild grape (Vitis quinquangularis)
  • WRKY transcription factor
  • disease resistance
  • leaf senescence
  • stilbene
  • transcriptional regulation


On the role of ageing and musculoskeletal pain on dynamic balance in manual workers.


MeSH Terms

  • Aged
  • Aging
  • Female
  • Humans
  • Male
  • Middle Aged
  • Muscle, Skeletal
  • Musculoskeletal Pain
  • Occupational Diseases
  • Postural Balance

Keywords

  • Discomfort
  • Lower extremity function
  • Posturography
  • Sit-to-stand

SUCNR1[править]

[The effect of Mexidol on cerebral mitochondriogenesis at a young age and during aging].


MeSH Terms

  • Age Factors
  • Aging
  • Animals
  • Male
  • Mitochondria
  • Neurodegenerative Diseases
  • Picolines
  • Rats
  • Receptors, G-Protein-Coupled
  • Transcription Factors

Keywords

  • Western blot analysis
  • aging
  • cerebral mitochondriogenesis
  • mexidol
  • mitochondrial dysfunction
  • rats
  • respiratory enzyme subunits
  • succinate receptor
  • transcriptional coactivator PGC-1α

SUGCT[править]

Knockout of the non-essential gene SUGCT creates diet-linked, age-related microbiome disbalance with a diabetes-like metabolic syndrome phenotype.


MeSH Terms

  • Aging
  • Animals
  • Anti-Bacterial Agents
  • Bacteria
  • Carnitine
  • Coenzyme A-Transferases
  • Dietary Supplements
  • Feces
  • Gastrointestinal Microbiome
  • Humans
  • Kidney
  • Lipid Metabolism
  • Liver
  • Lysine
  • Metabolic Syndrome
  • Metabolome
  • Mice
  • Mice, Knockout
  • Obesity
  • Tryptophan

Keywords

  • C7orf10
  • Glutaric aciduria type 3 (GA3)
  • Gut microflora
  • Lipids
  • Metabolomics
  • Obesity
  • Sugct

SUV39H1[править]

Increase in hippocampal histone H3K9me3 is negatively correlated with memory in old male mice.


Keywords

  • Aging
  • H3K9me3
  • Hippocampus
  • IEGs
  • Memory
  • SUV39H1

SYK[править]

miR-25-3p promotes endothelial cell angiogenesis in aging mice via TULA-2/SYK/VEGFR-2 downregulation.


Keywords

  • TULA-2
  • aging
  • angiogenesis
  • endothelial cell
  • miR-25-3p


Identification of SYK inhibitor, R406 as a novel senolytic agent.


Keywords

  • FAK
  • apoptosis
  • cellular senescence
  • p38
  • senolytics

SYNE1[править]

Nesprin-1 impact on tumorigenic cell phenotypes.


MeSH Terms

  • Actins
  • Carcinogenesis
  • Cell Line, Tumor
  • Cell Nucleus
  • Cytoskeletal Proteins
  • Gene Expression
  • Gene Expression Regulation, Neoplastic
  • Humans
  • Microfilament Proteins
  • Nerve Tissue Proteins
  • Nuclear Envelope
  • Phenotype

Keywords

  • Cancer
  • Cellular senescence
  • Genome stability
  • Nesprin-1
  • Nuclear envelope

TAAR1[править]

Minimal Age-Related Alterations in Behavioral and Hematological Parameters in Trace Amine-Associated Receptor 1 (TAAR1) Knockout Mice.


MeSH Terms

  • Age Factors
  • Animals
  • Anxiety
  • Dose-Response Relationship, Drug
  • Male
  • Mice
  • Mice, 129 Strain
  • Mice, Inbred C57BL
  • Mice, Knockout
  • Receptors, G-Protein-Coupled
  • Sodium Chloride

Keywords

  • Aging
  • Anxiety
  • Hematology
  • Leukocytes
  • Neutrophils
  • TAAR1
  • Thyroid
  • Trace amines

TAS2R16[править]

Taste receptor polymorphisms and longevity: a systematic review and meta-analysis.


Keywords

  • Immune-inflammatory responses
  • Longevity
  • Meta-analysis
  • Taste receptors

TAS2R38[править]

TAS2R38 bitter taste receptor and attainment of exceptional longevity.


MeSH Terms

  • Adolescent
  • Adult
  • Aged
  • Aged, 80 and over
  • Case-Control Studies
  • Female
  • Food Preferences
  • Gene Frequency
  • Genetic Variation
  • Haplotypes
  • Humans
  • Longevity
  • Male
  • Middle Aged
  • Receptors, G-Protein-Coupled
  • Taste
  • Taste Perception
  • Young Adult

TAZ[править]

Transcriptional Coactivator TAZ Negatively Regulates Tumor Suppressor p53 Activity and Cellular Senescence.


Keywords

  • TAZ
  • cellular senescence
  • oncogene
  • p300
  • p53

TBC1D5[править]

TBC1D5-Catalyzed Cycling of Rab7 Is Required for Retromer-Mediated Human Papillomavirus Trafficking during Virus Entry.


Keywords

  • HPV
  • Rab7B
  • TBC1D5
  • functional genetics screen
  • proximity ligation assay
  • retrograde
  • retromer
  • senescence
  • traptamer


Retromer and TBC1D5 maintain late endosomal RAB7 domains to enable amino acid-induced mTORC1 signaling.


MeSH Terms

  • Animals
  • Caenorhabditis elegans
  • Caenorhabditis elegans Proteins
  • Longevity
  • Mechanistic Target of Rapamycin Complex 1
  • Membrane Microdomains
  • Signal Transduction
  • rab GTP-Binding Proteins

TBK1[править]

Parkin overexpression alleviates cardiac aging through facilitating K63-polyubiquitination of TBK1 to facilitate mitophagy.


Keywords

  • Aging
  • K63-linked polyubiquitination
  • Mitophagy
  • Parkin
  • TBK1

TCF7L2[править]

A myelin-related transcriptomic profile is shared by Pitt-Hopkins syndrome models and human autism spectrum disorder.


MeSH Terms

  • Aging
  • Animals
  • Autism Spectrum Disorder
  • Cell Count
  • DNA Fingerprinting
  • Facies
  • Gene Expression Regulation
  • Humans
  • Hyperventilation
  • Intellectual Disability
  • Methyl-CpG-Binding Protein 2
  • Mice
  • Mice, Knockout
  • Myelin Sheath
  • Oligodendroglia
  • PTEN Phosphohydrolase
  • Primary Cell Culture
  • Signal Transduction
  • Transcription Factor 4
  • Transcriptome

TEC[править]

Vestibular function and cortical and sub-cortical alterations in an aging population.


Keywords

  • Aging
  • Cognition
  • Diffeomorphometry
  • Epidemiology
  • Eye-ear-nose-throat
  • MRI
  • Medical imaging
  • Shape
  • Vestibular
  • Volume


Metabolic Flexibility and Innate Immunity in Renal Ischemia Reperfusion Injury: The Fine Balance Between Adaptive Repair and Tissue Degeneration.


Keywords

  • cell death
  • innate immunity
  • kidney transplantation
  • mitochondria
  • senescence
  • tubular repair


Postnatal Involution and Counter-Involution of the Thymus.


Keywords

  • Myc
  • aging
  • cyclin D1
  • growth
  • involution
  • thymus


Gender Disparity Impacts on Thymus Aging and LHRH Receptor Antagonist-Induced Thymic Reconstitution Following Chemotherapeutic Damage.


Keywords

  • aging
  • chemotherapy
  • gender
  • luteinizing hormone-releasing hormone
  • regeneration
  • sex hormone deprivation
  • thymic epithelial cell
  • thymus


Clonogenic Culture of Mouse Thymic Epithelial Cells.


MeSH Terms

  • Aging
  • Animals
  • Cell Differentiation
  • Cell Line
  • Coculture Techniques
  • Colony-Forming Units Assay
  • DNA-Binding Proteins
  • Epithelial Cells
  • Flow Cytometry
  • Fluorescent Antibody Technique, Direct
  • Fluorescent Dyes
  • Immunomagnetic Separation
  • Mice
  • Mice, Knockout
  • Primary Cell Culture
  • Rhodamines
  • Self Tolerance
  • Staining and Labeling
  • Stem Cells
  • Thymus Gland

Keywords

  • Clonogenic assay
  • Thymic epithelial cells
  • Thymic epithelial stem cells
  • Thymus

TEF[править]

Expression of human HSP27 in yeast extends replicative lifespan and uncovers a hormetic response.


Keywords

  • Aging
  • Cancer
  • HSP27
  • Hormesis
  • Neurodegeneratve diseases
  • Proteasome

TERT[править]

Telomeres and telomerase in risk assessment of cardiovascular diseases.


Keywords

  • Cardiovascular diseases
  • Senescence
  • Telomerase
  • Telomeres


A 4-Base-Pair Core-Enclosing Helix in Telomerase RNA Is Essential for Activity and for Binding to the Telomerase Reverse Transcriptase Catalytic Protein Subunit.


Keywords

  • RNA
  • RNP
  • TERT
  • TLC1
  • senescence
  • telomerase
  • telomerase RNA
  • telomere
  • two-hybrid screening
  • yeast


Angiotensin inhibition and cellular senescence in the developing rat kidney.


Keywords

  • Apoptosis
  • Cellular senescence
  • Fetal development
  • Kidney
  • Renin-angiotensin system


Decreased expression of TERT and telomeric proteins as human ovaries age may cause telomere shortening.


Keywords

  • Ovarian aging
  • TERT
  • Telomere
  • Telomere-binding proteins


The secrets of telomerase: Retrospective analysis and future prospects.


MeSH Terms

  • Aging
  • Animals
  • Diabetes Mellitus
  • Humans
  • Neoplasms
  • Telomerase
  • Telomere Shortening

Keywords

  • Cancers
  • G-quadruplex formation
  • Metabolic disorders
  • TERT gene
  • Telomere-telomerase system


Gene expression in human mesenchymal stem cell aging cultures: modulation by short peptides.


Keywords

  • Cell aging
  • Genes
  • Human mesenchymal stem cells
  • Short peptides


Unravelling Cellular Mechanisms of Stem Cell Senescence: An Aid from Natural Bioactive Molecules.


Keywords

  • cellular mechanisms
  • gene expression
  • nutraceuticals
  • oxidative stress
  • senescence
  • stem cells


Expression of telomerase reverse transcriptase positively correlates with duration of lithium treatment in bipolar disorder.


MeSH Terms

  • Adult
  • Aging
  • Antimanic Agents
  • Bipolar Disorder
  • Cellular Senescence
  • Female
  • Humans
  • Lithium
  • Lithium Compounds
  • Male
  • Middle Aged
  • Mitochondria
  • Oxidative Stress
  • Polymorphism, Single Nucleotide
  • Real-Time Polymerase Chain Reaction
  • Telomerase
  • Telomere
  • Telomere Homeostasis
  • Telomere Shortening

Keywords

  • Affective disorder
  • Aging
  • Mitochondria
  • Oxidative stress
  • TERT
  • Telomere


FAM96B inhibits the senescence of dental pulp stem cells.


Keywords

  • FAM96B
  • aging
  • dental pulp stem cells (DPSCs)
  • proteomic analysis


Aging and biomarkers: Transcriptional levels evaluation of Osteopontin/miRNA-181a axis in hepatic tissue of rats in different age ranges.


Keywords

  • Aging
  • Long non-coding RNA
  • Osteopontin
  • Telomeres
  • miRNA


Resveratrol inhibits adipocyte differentiation and cellular senescence of human bone marrow stromal stem cells.


Keywords

  • Adipogenesis
  • Antioxidant
  • Bone marrow adiposity
  • Bone marrow skeletal stromal cells
  • Cellular senescence
  • Osteogenesis


Characterization of human telomerase reverse transcriptase immortalized anterior cruciate ligament cell lines.


MeSH Terms

  • Adolescent
  • Aged
  • Anterior Cruciate Ligament
  • Cell Differentiation
  • Cell Separation
  • Cells, Cultured
  • Humans
  • Mesenchymal Stem Cells
  • Telomerase

Keywords

  • Anterior cruciate ligament
  • Immortalization
  • Mesenchymal stem cells
  • Multilineage differentiation
  • Senescence


Mitochondria, Telomeres and Telomerase Subunits.


Keywords

  • TERC
  • TERT
  • aging
  • mitochondria
  • telomerase
  • telomere


Towards Therapeutic Alternatives for Mercury Neurotoxicity in the Amazon: Unraveling the Pre-Clinical Effects of the Superfruit Açaí ([i]Euterpe oleracea[/i], Mart.) as Juice for Human Consumption.


MeSH Terms

  • Animals
  • Antioxidants
  • Behavior, Animal
  • Brain Chemistry
  • Euterpe
  • Fruit and Vegetable Juices
  • Lipid Peroxidation
  • Male
  • Mercury
  • Mice
  • Motor Skills
  • Neurotoxins
  • Plant Extracts
  • Telomere

Keywords

  • Euterpe
  • acai
  • aging
  • antioxidant
  • açaí
  • extract
  • intoxication
  • methylmercury
  • telomere


Replication Stress at Telomeric and Mitochondrial DNA: Common Origins and Consequences on Ageing.


MeSH Terms

  • Aging
  • Animals
  • Cellular Senescence
  • DNA Damage
  • DNA Replication
  • DNA, Mitochondrial
  • Epigenesis, Genetic
  • Humans
  • Mitochondria
  • Oxidative Stress
  • Stress, Physiological
  • Telomere
  • Telomere Homeostasis
  • Telomere Shortening

Keywords

  • G-quadruplex
  • R-loop
  • ageing
  • helicase
  • mitochondria
  • replication stress
  • senescence
  • telomere


Telomerase Biology Associations Offer Keys to Cancer and Aging Therapeutics.


Keywords

  • Aging
  • TERT
  • associates
  • cancer
  • cell cycle
  • diseases
  • oncogenes
  • viral infection.


Transient induction of telomerase expression mediates senescence and reduces tumorigenesis in primary fibroblasts.


MeSH Terms

  • Animals
  • Cell Cycle
  • Cell Transformation, Neoplastic
  • Cells, Cultured
  • Cellular Senescence
  • Fibroblasts
  • Gene Expression
  • Gene Expression Regulation
  • Gene Knockdown Techniques
  • Humans
  • Mice
  • Mice, Inbred C57BL
  • Mice, Knockout
  • Phenotype
  • Telomerase
  • Telomere

Keywords

  • ATM
  • senescence
  • telomerase
  • tumorigenesis

TET2[править]

Non-coding and Loss-of-Function Coding Variants in TET2 are Associated with Multiple Neurodegenerative Diseases.


MeSH Terms

  • Aged
  • Aged, 80 and over
  • Alzheimer Disease
  • Animals
  • Cognition
  • DNA-Binding Proteins
  • Female
  • Frontotemporal Dementia
  • Humans
  • Loss of Function Mutation
  • Male
  • Mice
  • Neurodegenerative Diseases
  • Proto-Oncogene Proteins

Keywords

  • AD
  • ALS
  • Alzheimer
  • FTD
  • TET2
  • aging
  • amyotrophic lateral sclerosis
  • frontotemporal dementia
  • genome sequencing
  • non-coding


60 Years of clonal hematopoiesis research: From X-chromosome inactivation studies to the identification of driver mutations.


MeSH Terms

  • Adult
  • Aging
  • Biomedical Research
  • Chromosomes, Human, X
  • DNA-Binding Proteins
  • Female
  • Hematopoiesis
  • Hematopoietic Stem Cells
  • History, 20th Century
  • History, 21st Century
  • Humans
  • Male
  • Mutation
  • Proto-Oncogene Proteins
  • Receptors, Androgen
  • Repressor Proteins
  • X Chromosome Inactivation


DNA methylation instability by BRAF-mediated TET silencing and lifestyle-exposure divides colon cancer pathways.


MeSH Terms

  • Animals
  • Caco-2 Cells
  • Cell Line, Tumor
  • Colonic Neoplasms
  • DNA Methylation
  • DNA-Binding Proteins
  • Down-Regulation
  • Epigenesis, Genetic
  • Female
  • Gene Regulatory Networks
  • HT29 Cells
  • Humans
  • Male
  • Mice
  • Mixed Function Oxygenases
  • Mutation
  • Neoplasms, Experimental
  • Proto-Oncogene Proteins
  • Proto-Oncogene Proteins B-raf

Keywords

  • Aging
  • BRAF V600E
  • CIMP
  • Colon cancer
  • DNA methylation
  • TET


Clonal haematopoiesis: connecting ageing and inflammation in cardiovascular disease.


MeSH Terms

  • Adult
  • Age Factors
  • Aged
  • Aged, 80 and over
  • Aging
  • Animals
  • Cardiovascular Diseases
  • DNA (Cytosine-5-)-Methyltransferases
  • DNA-Binding Proteins
  • Genetic Predisposition to Disease
  • Hematopoiesis
  • Hematopoietic Stem Cells
  • Humans
  • Inflammation
  • Middle Aged
  • Mutation
  • Phenotype
  • Proto-Oncogene Proteins
  • Repressor Proteins
  • Risk Assessment
  • Risk Factors

TF[править]

A preliminary investigation of the contribution of different tenderness factors to beef loin, tri-tip and heel tenderness.


Keywords

  • Aging
  • Beef
  • Collagen
  • Tenderness
  • Trained panel


The transcription factor ZmNAC126 accelerates leaf senescence downstream of the ethylene signalling pathway in maize.


Keywords

  • ZmNAC
  • chlorophyll catabolic genes
  • ethylene
  • leaf senescence
  • maize


Extensive transcriptome changes during seasonal leaf senescence in field-grown black cottonwood (Populus trichocarpa Nisqually-1).


MeSH Terms

  • Aging
  • Gene Expression Profiling
  • Gene Expression Regulation, Plant
  • Genome, Plant
  • Photosynthesis
  • Plant Leaves
  • Populus
  • Seasons
  • Transcription Factors
  • Transcriptome


Expression of Transferrin and Albumin in the Sperm-Storage Tubules of Japanese Quail and their Possible Involvement in Long-Term Sperm Storage.


Keywords

  • Japanese quail
  • albumin
  • sperm longevity
  • sperm storage tubules
  • transferrin


OsWRKY5 Promotes Rice Leaf Senescence via Senescence-Associated NAC and Abscisic Acid Biosynthesis Pathway.


MeSH Terms

  • Abscisic Acid
  • Chlorophyll
  • Gene Expression Regulation, Plant
  • Gene Knockdown Techniques
  • Oryza
  • Plant Leaves
  • Plant Proteins
  • Transcription Factors

Keywords

  • NAC
  • OsWRKY
  • abscisic acid (ABA)
  • leaf senescence
  • rice


BrTCP7 Transcription Factor Is Associated with MeJA-Promoted Leaf Senescence by Activating the Expression of [i]BrOPR3[/i] and [i]BrRCCR[/i].


MeSH Terms

  • Amino Acid Sequence
  • Brassica
  • Cellular Senescence
  • Cyclopentanes
  • Gene Expression Regulation, Plant
  • Oxylipins
  • Phenotype
  • Phylogeny
  • Plant Growth Regulators
  • Plant Leaves
  • Plant Proteins
  • Promoter Regions, Genetic
  • Protein Binding
  • Transcription Factors

Keywords

  • Chinese flowering cabbage
  • JA
  • leaf senescence
  • transcriptional activation


Activation of the Transcription of [i]BrGA20ox3[/i] by a BrTCP21 Transcription Factor Is Associated with Gibberellin-Delayed Leaf Senescence in Chinese Flowering Cabbage during Storage.


MeSH Terms

  • Aging
  • Base Sequence
  • Brassica
  • Food Preservation
  • Gene Expression Regulation, Plant
  • Gibberellins
  • Phenotype
  • Phylogeny
  • Plant Leaves
  • Plant Proteins
  • Promoter Regions, Genetic
  • Protein Binding
  • Transcription Factors

Keywords

  • Chinese flowering cabbage
  • GA
  • leaf senescence
  • transcriptional activation

TFEB[править]

A Novel Lipofuscin-detecting Marker of Senescence Relates With Hypoxia, Dysregulated Autophagy and With Poor Prognosis in Non-small-cell-lung Cancer.


Keywords

  • Senescence
  • autophagy
  • glycolysis
  • hypoxia
  • lipofuscin
  • lung cancer


ESC-sEVs Rejuvenate Senescent Hippocampal NSCs by Activating Lysosomes to Improve Cognitive Dysfunction in Vascular Dementia.


Keywords

  • embryonic stem cells derived small extracellular vesicles (ESC‐sEVs)
  • hippocampal neural stem cells (HNSCs)
  • lysosomes
  • senescence
  • vascular dementia


Nitrative Stress-Related Autophagic Insufficiency Participates in Hyperhomocysteinemia-Induced Renal Aging.


MeSH Terms

  • Aging
  • Animals
  • Autophagy
  • Cells, Cultured
  • Homocysteine
  • Humans
  • Hyperhomocysteinemia
  • Kidney
  • Kidney Diseases
  • Male
  • Metalloporphyrins
  • Peroxynitrous Acid
  • Rats
  • Rats, Sprague-Dawley


Polyamines reverse immune senescence via the translational control of autophagy.


MeSH Terms

  • Aging
  • Animals
  • Autophagy
  • Humans
  • Lysosomes
  • Polyamines
  • Protein Processing, Post-Translational
  • Spermidine

Keywords

  • Aging
  • B cells
  • EIF5A
  • TFEB
  • autophagy
  • hypusine
  • spermidine
  • translation


Polyamines Control eIF5A Hypusination, TFEB Translation, and Autophagy to Reverse B Cell Senescence.


MeSH Terms

  • Adaptive Immunity
  • Age Factors
  • Aging
  • Animals
  • Autophagy
  • B-Lymphocytes
  • Basic Helix-Loop-Helix Leucine Zipper Transcription Factors
  • Cellular Senescence
  • HEK293 Cells
  • Humans
  • Immunologic Memory
  • Immunosenescence
  • Jurkat Cells
  • Mice
  • Mice, Inbred C57BL
  • Mice, Knockout
  • NIH 3T3 Cells
  • Peptide Initiation Factors
  • Protein Processing, Post-Translational
  • RNA-Binding Proteins
  • Signal Transduction
  • Spermidine

Keywords

  • B cell
  • TFEB
  • aging
  • autophagy
  • eIF5A
  • spermidine

TFPI[править]

Identification of cardiovascular health gene variants related to longevity in a Chinese population.


Keywords

  • Chinese
  • factor related to cardiovascular health (FCH)
  • genetic variation
  • lipid metabolism
  • longevity

TG[править]

Inhibition of the alternative lengthening of telomeres pathway by subtelomeric sequences in Saccharomyces cerevisiae.


Keywords

  • Budding yeast
  • Rad52
  • Replicative senescence
  • Subtelomeric Y’ elements
  • Telomerase-independent telomere maintenance
  • Telomere recombination


E4orf1, an Adeno-viral protein, attenuates renal lipid accumulation in high fat fed mice: A novel approach to reduce a key risk factor for chronic kidney disease.


Keywords

  • Aging
  • CKD
  • Diabetes
  • Diet
  • E4orf1
  • FA synthesis
  • Hyperinsulinemia
  • Insulin
  • Lipid metabolism
  • Obesity


Resistance exercise attenuates postprandial metabolic responses to a high-fat meal similarly in younger and older men.


Keywords

  • Aging
  • Cardiometabolic
  • Lipemia
  • Metabolism
  • Nutrition


Aging-induced aberrant RAGE/PPARα axis promotes hepatic steatosis via dysfunctional mitochondrial β oxidation.


Keywords

  • PPARα
  • RAGE
  • aging
  • hepatic steatosis
  • mitochondria


Fenofibrate impairs liver function and structure more pronounced in old than young rats.


Keywords

  • Aging
  • Fenofibrate
  • Lipids
  • Liver function and morphology
  • Rat
  • serum


Awareness of major cardiovascular risk factors and its relationship with markers of vascular aging: Data from the Brisighella Heart Study.


MeSH Terms

  • Adolescent
  • Adult
  • Age Factors
  • Aged
  • Aged, 80 and over
  • Aging
  • Biomarkers
  • Blood Glucose
  • Blood Pressure
  • Cardiovascular Diseases
  • Cholesterol
  • Cross-Sectional Studies
  • Diabetes Mellitus
  • Female
  • Humans
  • Hypercholesterolemia
  • Hypertension
  • Hypertriglyceridemia
  • Italy
  • Male
  • Middle Aged
  • Risk Assessment
  • Risk Factors
  • Triglycerides
  • Vascular Stiffness
  • Young Adult

Keywords

  • Arterial aging
  • Awareness
  • Epidemiology
  • Pulse wave velocity
  • Risk factors


Characterisation of the dynamic nature of lipids throughout the lifespan of genetically identical female and male Daphnia magna.


MeSH Terms

  • Aging
  • Animals
  • Daphnia
  • Diglycerides
  • Female
  • Lipid Metabolism
  • Longevity
  • Male
  • Phosphatidylcholines
  • Sphingomyelins
  • Triglycerides


Effects of laboratory biotic aging on the characteristics of biochar and its water-soluble organic products.


MeSH Terms

  • Benzopyrans
  • Charcoal
  • Humic Substances
  • Microbiota
  • Soil Microbiology
  • Solubility
  • Triticum
  • Water

Keywords

  • Biochar
  • Biotic incubation aging
  • Dissolved organic matter (DOM)
  • Excitation-emission matrix
  • Humification


Using Caenorhabditis elegans for Studying Trans- and Multi-Generational Effects of Toxicants.


MeSH Terms

  • Animals
  • Caenorhabditis elegans
  • Hazardous Substances
  • Humans
  • Longevity
  • Reproduction
  • Toxicity Tests

TH[править]

Thyroid hormone signaling is associated with physical performance, muscle mass, and strength in a cohort of oldest-old: results from the Mugello study.


Keywords

  • Aging
  • Muscle mass
  • Muscle strength
  • Oldest-old
  • Physical performance
  • Rehabilitation
  • Thyroid hormone signaling


Social Environment Ameliorates Behavioral and Immune Impairments in Tyrosine Hydroxylase Haploinsufficient Female Mice.


Keywords

  • Behavioral responses
  • Immunosenescence
  • Oxidative-inflammatory stress
  • Social environmental strategy
  • Tyrosine hydroxylase haploinsufficient mice


Mechanism of thyroid hormone signaling in skeletal muscle of aging mice.


Keywords

  • Aging
  • Mice
  • Skeletal muscle
  • Thyroid hormone signaling


Longitudinal changes in bone mineral density and trabecular bone score in Korean adults: a community-based prospective study.


MeSH Terms

  • Absorptiometry, Photon
  • Adult
  • Bone Density
  • Cancellous Bone
  • Cohort Studies
  • Female
  • Humans
  • Lumbar Vertebrae
  • Male
  • Prospective Studies
  • Republic of Korea

Keywords

  • Aging
  • Bone mineral density
  • Natural history
  • Osteoporosis


Quantitative proteomic profiling of the rat substantia nigra places glial fibrillary acidic protein at the hub of proteins dysregulated during aging: Implications for idiopathic Parkinson's disease.


Keywords

  • RRID:AB_11145309
  • RRID:AB_2109791
  • RRID:AB_228307
  • RRID:AB_228341
  • RRID:AB_2336820
  • RRID:AB_2631098
  • RRID:AB_390204
  • RRID:MGI:5651135
  • RRID:SCR_001881
  • RRID:SCR_002798
  • RRID:SCR_003070
  • RRID:SCR_004946
  • RRID:SCR_005223
  • aging
  • dopaminergic neuron
  • glial fibrillary acidic protein
  • proteome
  • proteomics
  • substantia nigra


Withaferin-A Protects the Nigral Dopamine Neuron and Recovers Motor Activity in Aged Rats.


MeSH Terms

  • Aging
  • Animals
  • Brain
  • Corpus Striatum
  • Dopaminergic Neurons
  • Male
  • Motor Activity
  • Neuroprotective Agents
  • Rats
  • Rats, Wistar
  • Substantia Nigra
  • Tyrosine 3-Monooxygenase
  • Withanolides

Keywords

  • Ageing
  • Dopamine
  • Striatum
  • Substantia nigra
  • Withaferin-A


Effects of physical activity on bone mineral density in older adults: Korea National Health and Nutrition Examination Survey, 2008-2011.


MeSH Terms

  • Absorptiometry, Photon
  • Aged
  • Bone Density
  • Cross-Sectional Studies
  • Exercise
  • Female
  • Femur Neck
  • Humans
  • Lumbar Vertebrae
  • Male
  • Middle Aged
  • Nutrition Surveys
  • Osteoporosis
  • Republic of Korea
  • Surveys and Questionnaires

Keywords

  • Aging
  • Bone mineral density
  • Exercise
  • Gender
  • Osteoporosis
  • Physical activity


Age-Related Resistance to Thyroid Hormone Action.


MeSH Terms

  • Aged
  • Aged, 80 and over
  • Aging
  • Animals
  • Humans
  • Hyperthyroidism
  • Hypothyroidism
  • Iodide Peroxidase
  • Male
  • Receptors, Thyroid Hormone
  • Thyroid Hormones
  • Thyroxine
  • Triiodothyronine


Age-Dependent Changes in Glucose Homeostasis in Male Deiodinase Type 2 Knockout Zebrafish.


MeSH Terms

  • Aging
  • Animals
  • Animals, Genetically Modified
  • Glucose
  • Glucose Transport Proteins, Facilitative
  • Homeostasis
  • Hyperglycemia
  • Iodide Peroxidase
  • Islets of Langerhans
  • Male
  • Proglucagon
  • Proinsulin
  • Receptor, Insulin
  • Receptors, Glucagon
  • Zebrafish


Age effect on thyroid hormone brain response in male mice.


MeSH Terms

  • Aging
  • Animals
  • Brain
  • Gene Expression
  • Hyperthyroidism
  • Hypothyroidism
  • Male
  • Maze Learning
  • Mice, Inbred C57BL
  • Monocarboxylic Acid Transporters
  • Organic Cation Transport Proteins
  • Rotarod Performance Test
  • Symporters
  • Thyroid Hormones
  • Thyrotropin
  • Thyrotropin-Releasing Hormone

Keywords

  • Ageing
  • Hyperthyroidism
  • Hypothyroidism
  • Male mice
  • Thyroid hormones


Aging Is Associated with Low Thyroid State and Organ-Specific Sensitivity to Thyroxine.


MeSH Terms

  • Aging
  • Animals
  • DNA-Binding Proteins
  • Hypothalamo-Hypophyseal System
  • Liver
  • Male
  • Mice
  • Mice, Inbred C57BL
  • Myocardium
  • Pituitary Gland
  • Thyroid Gland
  • Thyroid Hormones
  • Thyrotropin
  • Thyroxine
  • Transcription Factors

Keywords

  • HPT-axis
  • aging
  • mice
  • thyroid gland
  • thyroid hormones

TLR1[править]

Effects of aging and lifelong aerobic exercise on expression of innate immune components in human skeletal muscle.


Keywords

  • TLR
  • aging
  • innate immunity
  • lifelong exercise
  • skeletal muscle


Association of TLR gene variants in a Czech Red Pied cattle population with reproductive traits.


MeSH Terms

  • Age Factors
  • Animals
  • Breeding
  • Cattle
  • Czech Republic
  • Female
  • Genotype
  • Longevity
  • Male
  • Phenotype
  • Polymorphism, Single Nucleotide
  • Reproduction
  • Toll-Like Receptor 1
  • Toll-Like Receptor 2
  • Toll-Like Receptor 6
  • Toll-Like Receptors

Keywords

  • Cattle
  • Diversity
  • Effect prediction
  • Health traits
  • Toll-like receptors

TLR2[править]

Changes in salivary microbial sensing proteins CD14 and TLR2 with aging.


MeSH Terms

  • Adolescent
  • Adult
  • Aging
  • Biomarkers
  • Child
  • Child, Preschool
  • Humans
  • Lipopolysaccharide Receptors
  • Middle Aged
  • Saliva
  • Salivary Proteins and Peptides
  • Toll-Like Receptor 2
  • Young Adult

Keywords

  • Age changes
  • CD14
  • Saliva
  • Toll-like receptor-2


Culture Model for Non-human Primate Choroid Plexus.


Keywords

  • aging
  • cell culture
  • choroid plexus
  • epithelial cell
  • infectious disease
  • rhesus macaque

TLR4[править]

Age-Dependent Changes of Adipokine and Cytokine Secretion From Rat Adipose Tissue by Endogenous and Exogenous Toll-Like Receptor Agonists.


Keywords

  • adipokines
  • aging
  • batokines
  • biglycan
  • cytokines
  • fat explant cultures
  • high mobility group box-1 protein
  • lipopolysaccharide


Role of Toll Like Receptor 4 in Alzheimer's Disease.


Keywords

  • Alzheimer’s disease
  • TLR4
  • aging
  • amyloid beta oligomers
  • calcium
  • hippocampal neurons


Commentary on Some Recent Theses Relevant to Combating Aging: August 2020.


Keywords

  • aging
  • dissertations
  • theses


Sialylation and Galectin-3 in Microglia-Mediated Neuroinflammation and Neurodegeneration.


Keywords

  • aging
  • desialylation
  • galectin-3
  • microglia
  • neurodegeneration
  • phagocytosis
  • sialic acid


Chemerin facilitates intervertebral disc degeneration via TLR4 and CMKLR1 and activation of NF-kB signaling pathway.


Keywords

  • chemerin
  • inflammation
  • intervertebral disc
  • nucleus pulposus
  • senescence


Toll-like receptor 4 differentially regulates adult hippocampal neurogenesis in an age- and sex-dependent manner.


Keywords

  • TLR4
  • adult hippocampal neurogenesis
  • aging
  • proliferation
  • sex differences


Aging-associated immunosenescence via alterations in splenic immune cell populations in rat.


MeSH Terms

  • Animals
  • B-Lymphocytes
  • Cells, Cultured
  • Immunity, Cellular
  • Immunosenescence
  • Male
  • Malondialdehyde
  • Oxidative Stress
  • Rats
  • Rats, Wistar
  • Spleen
  • Superoxide Dismutase
  • T-Lymphocytes

Keywords

  • Aging
  • Immunohistochemistry
  • Immunosenescence
  • Oxidative stress
  • Spleen


Leptin induces immunosenescence in human B cells.


MeSH Terms

  • Adult
  • Aged
  • B-Lymphocytes
  • Humans
  • Immunoglobulin Class Switching
  • Immunosenescence
  • Leptin
  • Middle Aged
  • Obesity

Keywords

  • B cells
  • Immunosenescence
  • Leptin
  • Obesity


Genetic Variation in the Magnitude and Longevity of the IgG Subclass Response to a Diphtheria-Tetanus-Acellular Pertussis (DTaP) Vaccine in Mice.


Keywords

  • DTaP
  • IgG subclass
  • antibody longevity
  • antibody magnitude
  • genetics
  • vaccine


Rapamycin improves sevoflurane‑induced cognitive dysfunction in aged rats by mediating autophagy through the TLR4/MyD88/NF‑κB signaling pathway.


MeSH Terms

  • Aging
  • Animals
  • Autophagic Cell Death
  • Cognitive Dysfunction
  • Male
  • Myeloid Differentiation Factor 88
  • NF-kappa B
  • Rats
  • Rats, Sprague-Dawley
  • Sevoflurane
  • Signal Transduction
  • Sirolimus
  • Toll-Like Receptor 4

TLR9[править]

Age-Associated B Cells.


Keywords

  • B lymphocytes
  • aging
  • autoimmunity
  • memory B cells

TMEM106B[править]

Genetics of Gene Expression in the Aging Human Brain Reveal TDP-43 Proteinopathy Pathophysiology.


MeSH Terms

  • Aged
  • Aged, 80 and over
  • Aging
  • Alzheimer Disease
  • Amyloid beta-Peptides
  • Apolipoproteins E
  • Brain
  • Cohort Studies
  • DNA-Binding Proteins
  • Female
  • Gene Expression Regulation
  • Haplotypes
  • Humans
  • Lysosomes
  • Male
  • Membrane Proteins
  • Myelin Sheath
  • Nerve Tissue Proteins
  • Progranulins
  • Quantitative Trait Loci
  • RNA Splicing Factors
  • TDP-43 Proteinopathies

Keywords

  • Alzheimer's disease
  • Amyloid-β
  • GRN
  • RBFOX1
  • TDP-43
  • TMEM106B
  • co-expression module
  • cognitive resilience
  • eQTL
  • expression quantitative trait loci
  • sQTL
  • splicing quantitative trait loci

TMPRSS2[править]

Susceptibility to COVID-19 in populations with health disparities: Posited involvement of mitochondrial disorder, socioeconomic stress, and pollutants.


Keywords

  • SARS-CoV-2
  • dysfunction
  • exposome
  • immunosenescence
  • metabolomics
  • mitochondria
  • pollutant
  • socioeconomic
  • stress


Expression of the SARS-CoV-2 Entry Proteins, ACE2 and TMPRSS2, in Cells of the Olfactory Epithelium: Identification of Cell Types and Trends with Age.


MeSH Terms

  • Age Factors
  • Angiotensin-Converting Enzyme 2
  • Animals
  • Betacoronavirus
  • COVID-19
  • Coronavirus Infections
  • Gene Expression
  • Gene Expression Profiling
  • Immunohistochemistry
  • In Situ Hybridization
  • Mice
  • Olfaction Disorders
  • Olfactory Mucosa
  • Olfactory Receptor Neurons
  • Pandemics
  • Peptidyl-Dipeptidase A
  • Pneumonia, Viral
  • RNA-Seq
  • Reverse Transcriptase Polymerase Chain Reaction
  • SARS-CoV-2
  • Serine Endopeptidases
  • Virus Internalization

Keywords

  • ACE2 expression
  • COVID-19
  • SARS-CoV-2
  • aging
  • anosmia
  • olfactory epithelium

TNC[править]

Effects of Tenascin C on the Integrity of Extracellular Matrix and Skin Aging.


Keywords

  • TGF-β
  • aging
  • collagen
  • extracellular matrix
  • fibroblast
  • skin
  • tenascin C


Tenascin-C expression controls the maturation of articular cartilage in mice.


MeSH Terms

  • Aging
  • Animals
  • Cartilage, Articular
  • Cell Count
  • Genotype
  • Mice
  • Tenascin

Keywords

  • Adhesion
  • Articular cartilage
  • Cartilage defect
  • Cell density
  • Knock-out mouse
  • Load
  • Tenascin C


Effects of hydrothermal aging, thermal cycling, and water storage on the mechanical properties of a machinable resin-based composite containing nano-zirconia fillers.


Keywords

  • Aging
  • Mechanical properties
  • Nano-zirconia
  • Phase transformation
  • Resin nano-ceramic
  • Resin-based composite

TNF[править]

Naringenin alleviates nonalcoholic steatohepatitis in middle-aged Apoe mice: role of SIRT1.


Keywords

  • AML-12 cells
  • Aging
  • ApoE(−/−) mice
  • Naringenin
  • Nonalcoholic steatohepatitis
  • SIRT1


Protective role of microglial HO-1 blockade in aging: Implication of iron metabolism.


Keywords

  • Aging
  • Ferroptosis
  • Heme oxygenase-1
  • Iron metabolism
  • Microglia
  • Neuroinflammation


Anti-aging effect of DL-β-hydroxybutyrate against hepatic cellular senescence induced by D-galactose or γ-irradiation via autophagic flux stimulation in male rats.


Keywords

  • Autophagy
  • D-galacose
  • Ionizing radiation
  • Senescence
  • β-hydroxybutyric acid


Exploring the extensive crosstalk between the antagonistic cytokines- TGF-β and TNF-α in regulating cancer pathogenesis.


Keywords

  • Apoptosis
  • Autophagy
  • EMT
  • Fibrogenesis
  • Senescence
  • TGF-β and TNF-α


Long non-coding RNA SNHG29 regulates cell senescence via p53/p21 signaling in spontaneous preterm birth.


Keywords

  • Cellular senescence
  • Oxidative stress
  • SASP
  • SNHG29
  • Spontaneous preterm birth
  • p53/p21


Cognition Is Associated With Peripheral Immune Molecules in Healthy Older Adults: A Cross-Sectional Study.


Keywords

  • chemokines
  • cognition
  • cytokines
  • healthy aging
  • immune molecules


Anti-aging effects of [i]Ribes meyeri[/i] anthocyanins on neural stem cells and aging mice.


Keywords

  • Ribes meyeri anthocyanin
  • aging
  • cognition
  • naringenin
  • senescence


Effects of a four week detraining period on physical, metabolic, and inflammatory profiles of elderly women who regularly participate in a program of strength training.


Keywords

  • Aging
  • Inflammation
  • Physical exercise


Contribution of Porphyromonas gingivalis lipopolysaccharide to experimental periodontitis in relation to aging.


Keywords

  • Aging
  • Bone loss
  • Osteoclastogenesis
  • Periodontitis
  • Porphyromonas gingivalis lipopolysaccharide


New MoDC-Targeting TNF Fusion Proteins Enhance Cyclic Di-GMP Vaccine Adjuvanticity in Middle-Aged and Aged Mice.


Keywords

  • 3′
  • 5′-cyclic diguanylic acid (cyclic di-GMP)
  • aging
  • monocyte-derived dendritic cells (moDCs)
  • tumor necrosis factor (TNF)
  • vaccine


Cognitive impairment in elderly patients with rheumatic disease and the effect of disease-modifying anti-rheumatic drugs.


Keywords

  • Aging
  • Biologics
  • Cognition
  • Rheumatic diseases


Cotinine ameliorates memory and learning impairment in senescent mice.


Keywords

  • Aging
  • Cognitive impairment
  • Cotinine
  • Improvement
  • α(7)nAChRs


Kynurenines link chronic inflammation to functional decline and physical frailty.


Keywords

  • Aging
  • Cytokines
  • Inflammation
  • Neurodegeneration


Voluntary exercise training attenuated the middle-aged maturity-induced cardiac apoptosis.


MeSH Terms

  • Aging
  • Animals
  • Apoptosis
  • Heart
  • In Situ Nick-End Labeling
  • Male
  • Mice
  • Mice, Inbred C57BL
  • Mitochondria, Heart
  • Muscle, Skeletal
  • Physical Conditioning, Animal
  • Running
  • Sedentary Behavior

Keywords

  • Caspase-independent
  • Cell death
  • Fas dependent
  • IGF-related
  • Mitochondrial


Preclinical Evaluation of a Food-Derived Functional Ingredient to Address Skeletal Muscle Atrophy.


Keywords

  • aging
  • bioactive
  • functional ingredient
  • immobilization
  • inflammation
  • muscle atrophy
  • peptide
  • protein synthesis
  • skeletal muscle


Childhood survivors of high-risk neuroblastoma show signs of immune recovery and not immunosenescence.


Keywords

  • adverse late effects
  • childhood
  • immune recovery
  • immunosenescence
  • neuroblastoma


FK506 induces lung lymphatic endothelial cell senescence and downregulates LYVE-1 expression, with associated decreased hyaluronan uptake.


Keywords

  • Endothelial cells
  • Fk506
  • Hyaluronan
  • LYVE-1
  • Lung lymphatic
  • Senescence
  • TERT


Late-onset hypogonadism: Reductio ad absurdum of the cardiovascular risk-benefit of testosterone replacement therapy.


Keywords

  • aging
  • androgen
  • heart failure
  • myocardial infarction
  • testosterone
  • thromboembolism


Doxorubicin generates senescent microglia that exhibit altered proteomes, higher levels of cytokine secretion, and a decreased ability to internalize amyloid β.


Keywords

  • Aging
  • Alzheimer's disease
  • Inflammation
  • Microglia
  • Proteomics
  • Senescence


Time restricted feeding provides a viable alternative to alternate day fasting when evaluated in terms of redox homeostasis in rats.


Keywords

  • Aging
  • Alternate day fasting (ADF)
  • Intermittent fasting (IF)
  • Oxidative stress
  • Time-Restricted feeding (TRF)


Associations Between Plasma Immunomodulatory and Inflammatory Mediators With VACS Index Scores Among Older HIV-Infected Adults on Antiretroviral Therapy.


Keywords

  • HIV
  • aging
  • anti-retroviral therapy
  • inflammation
  • morbidity


Chrysin Impact on Oxidative and Inflammation Damages in the Liver of Aged Male Rats.


Keywords

  • Aging
  • chrysin
  • inflammation
  • liver
  • oxidative stress
  • rat.


Correction of immunosuppression in aged septic rats by human ghrelin and growth hormone through the vagus nerve-dependent inhibition of TGF-β production.


Keywords

  • Aging
  • Ghrelin
  • Immunosuppression
  • Sepsis
  • Vagus nerve


Epigenetics of neuroinflammation: Immune response, inflammatory response and cholinergic synaptic involvement evidenced by genome-wide DNA methylation analysis of delirious inpatients.


Keywords

  • Aging
  • Delirium
  • Genome-wide DNA methylation
  • Immune response
  • Inflammatory response


[i]Andrographis paniculata[/i] and Its Bioactive Diterpenoids Against Inflammation and Oxidative Stress in Keratinocytes.


Keywords

  • Andrographis paniculata
  • andrographolide
  • inflammation
  • keratinocytes
  • oxidative stress
  • skin aging


Etanercept improves aging-induced cognitive deficits by reducing inflammation and vascular dysfunction in rats.


Keywords

  • Aging
  • Etanercept
  • Inflammation
  • Learning
  • Memory
  • TNFα
  • Vascular dementia


Bacterial antigen translocation and age as BMI-independent contributing factors on systemic inflammation in NAFLD patients.


Keywords

  • NAFLD
  • aging
  • bacterial translocation
  • cytokines
  • insulin resistance


Bone marrow mesenchymal stem cells improve thymus and spleen function of aging rats through affecting P21/PCNA and suppressing oxidative stress.


Keywords

  • BMSCs
  • P21/PCNA
  • aging
  • immune system
  • oxidative stress


Glycolic acid adjusted to pH 4 stimulates collagen production and epidermal renewal without affecting levels of proinflammatory TNF-alpha in human skin explants.


Keywords

  • cosmetics
  • glycolic acid
  • keratolytic agents
  • rejuvenation
  • skin aging


A20 of nucleus pulposus cells plays a self-protection role via the nuclear factor-kappa B pathway in the inflammatory microenvironment.


Keywords

  • A20
  • Nuclear factor-kappa B
  • Nucleus pulposus
  • Senescence
  • Tumour necrosis factor alpha


Age-associated decline in neural, endocrine, and immune responses in men and women: Involvement of intracellular signaling pathways.


MeSH Terms

  • Adult
  • Aging
  • Estradiol
  • Female
  • Humans
  • Hydrocortisone
  • Immunity, Cellular
  • Intracellular Fluid
  • Male
  • Middle Aged
  • Signal Transduction
  • Testosterone
  • Young Adult

Keywords

  • 17β-estradiol
  • Cortisol
  • Cytokines
  • Testosterone
  • Tyrosine hydroxylase


Classical and lectin complement pathways and markers of inflammation for investigation of susceptibility to infections among healthy older adults.


Keywords

  • Aging
  • Complement system
  • Elderly
  • Immune
  • Inflammation
  • Lectin


Activation of FoxO1/SIRT1/RANKL/OPG pathway may underlie the therapeutic effects of resveratrol on aging-dependent male osteoporosis.


Keywords

  • Aging
  • FoxO1
  • Male osteoporosois
  • OPG
  • RANKL
  • Resveratrol
  • SIRT1
  • Type II osteoporosis


The senescence-associated secretome as an indicator of age and medical risk.


Keywords

  • Aging
  • Cellular senescence


Exercise Partially Rejuvenates Muscle Stem Cells.


Keywords

  • TGF-beta
  • aging
  • cyclin D1
  • longevity
  • regeneration
  • stem cells


Brazilian berry extract (Myrciaria jaboticaba): A promising therapy to minimize prostatic inflammation and oxidative stress.


MeSH Terms

  • Age Factors
  • Animals
  • Anti-Inflammatory Agents
  • Antioxidants
  • Cyclooxygenase 2
  • Diet, High-Fat
  • Dose-Response Relationship, Drug
  • Fruit
  • Interleukin-1beta
  • Interleukin-6
  • Lipid Peroxidation
  • Male
  • Mice
  • Myrtaceae
  • Oxidative Stress
  • Plant Extracts
  • Prostatitis
  • T-Lymphocytes

Keywords

  • aging
  • bioactive compounds
  • obesity
  • overweight
  • polyphenols


Potential therapeutic effects of endothelial cells trans-differentiated from Wharton's Jelly-derived mesenchymal stem cells on altered vascular functions in aged diabetic rat model.


Keywords

  • Aging
  • Diabetes mellitus
  • Endothelial cells
  • Hypertension
  • Mesenchymal stem cells


[Effect of fragmented sleep on postoperative cognitive function and central neuroinflammation].


MeSH Terms

  • Aging
  • Animals
  • Cognition
  • Cognition Disorders
  • Fear
  • Hippocampus
  • Mice
  • Mice, Inbred ICR

Keywords

  • Central nervous system
  • Cognition disorders
  • Inflammation
  • Postoperative period
  • Sleep deprivation


Can blocking inflammation enhance immunity during aging?


Keywords

  • Inflammaging
  • p38-MAP Kinase
  • senescence
  • senolytics


[FAS- and TNF-dependent ways participation in apoptosis mechanisms in hypotalumus in physiological and pathological aging.]


MeSH Terms

  • Aging
  • Animals
  • Apoptosis
  • Female
  • Hypothalamus
  • Mice
  • Mice, Transgenic
  • Signal Transduction
  • Tumor Necrosis Factor-alpha
  • fas Receptor

Keywords

  • FAS-, TNF-dependent pathways
  • aging
  • apoptosis
  • hypothalamus
  • neurons


Ultrasound-guided continuous thoracic paravertebral block alleviates postoperative delirium in elderly patients undergoing esophagectomy: A randomized controlled trial.


MeSH Terms

  • Aged
  • Aged, 80 and over
  • Analgesia, Patient-Controlled
  • Delirium
  • Esophagectomy
  • Female
  • Geriatrics
  • Humans
  • Male
  • Middle Aged
  • Nerve Block
  • Postoperative Complications
  • Prospective Studies
  • Ultrasonography


17β-Estradiol improves insulin signalling and insulin resistance in the aged female hearts: Role of inflammatory and anti-inflammatory cytokines.


MeSH Terms

  • Aging
  • Animals
  • Anti-Inflammatory Agents
  • Blood Glucose
  • Cytokines
  • Estradiol
  • Female
  • Heart
  • Insulin
  • Insulin Resistance
  • Lipid Metabolism
  • Menopause
  • Ovariectomy
  • Rats
  • Rats, Wistar
  • Signal Transduction

Keywords

  • 17β-estradiol
  • Aging
  • Cytokines
  • Heart
  • Insulin signalling


Synergistic Antitumor Efficacy of Magnetohyperthermia and Poly(lactic-co-glycolic acid)-Encapsulated Selol in Ehrlich Breast Adenocarcinoma Treatment in Elderly Swiss Mice.


MeSH Terms

  • Adenocarcinoma
  • Aging
  • Animals
  • Cell Line, Tumor
  • Glycols
  • Humans
  • Mice
  • Nanoparticles
  • Polylactic Acid-Polyglycolic Acid Copolymer
  • Selenium Compounds


Pinitol suppresses TNF-α-induced chondrocyte senescence.


Keywords

  • Cellular senescence
  • Nrf2
  • Osteoarthritis
  • Pinitol
  • TNF-α


[Aging of skin fibroblasts: genetic and epigenetic factors.]


MeSH Terms

  • Cells, Cultured
  • Epigenesis, Genetic
  • Fibroblasts
  • Humans
  • Skin Aging

Keywords

  • aging
  • melatonin
  • signal molecules
  • skin fibroblasts


Functional and traditional training improve muscle power and reduce proinflammatory cytokines in older women: A randomized controlled trial.


Keywords

  • Aging
  • Cytokines.
  • Dynapenia
  • Inflamm-aging


Associations of TNF-α -308 G>A and TNF-β 252 A>G with Physical Function and BNP-Rugao Longevity and Ageing Study.


MeSH Terms

  • Aged
  • Aged, 80 and over
  • Aging
  • Female
  • Humans
  • Longevity
  • Male
  • Natriuretic Peptide, Brain
  • Tumor Necrosis Factor-alpha

Keywords

  • Physical function
  • TNF-α -308 G>A polymorphism
  • TNF-β 252 A>G polymorphism
  • plasma BNP
  • population study.


3D TECA hydrogel reduces cellular senescence and enhances fibroblasts migration in wound healing.


Keywords

  • 3D TECA
  • Cellular senescence
  • Fibroblast migration
  • SA-β-gal
  • TNF-α


Regulatory Effect of Anwulignan on the Immune Function Through Its Antioxidation and Anti-Apoptosis in D-Galactose-Induced Aging Mice.


MeSH Terms

  • Animals
  • Antioxidants
  • Apoptosis
  • Cytokines
  • Immunologic Factors
  • Immunosenescence
  • Male
  • Medicine, Chinese Traditional
  • Mice
  • Models, Animal
  • NF-E2-Related Factor 2
  • Oxidative Stress
  • Phytochemicals
  • Schisandra
  • Spleen

Keywords

  • Anwulignan
  • anti-apoptosis
  • antioxidation
  • immunosenescence


Pretreatment Frailty Is Independently Associated With Increased Risk of Infections After Immunosuppression in Patients With Inflammatory Bowel Diseases.


Keywords

  • Aging
  • Immunosuppression
  • Side Effect
  • Thiopurine


The Citrus Flavonoid Naringenin Protects the Myocardium from Ageing-Dependent Dysfunction: Potential Role of SIRT1.


MeSH Terms

  • Aging
  • Animals
  • Antioxidants
  • Cell Line
  • Cellular Senescence
  • Citrus
  • Cytoprotection
  • Disease Models, Animal
  • Flavanones
  • Humans
  • Interleukin-6
  • Mice
  • Myocardium
  • Protein Binding
  • Rats
  • Reactive Oxygen Species
  • Sirtuin 1
  • Tumor Necrosis Factor-alpha


In the Absence of a TCR Signal IL-2/IL-12/18-Stimulated γδ T Cells Demonstrate Potent Anti-Tumoral Function Through Direct Killing and Senescence Induction in Cancer Cells.


Keywords

  • IL-12
  • IL-18
  • TCR bypass stimulation
  • senescence
  • γδ T cells


Aging is associated with loss of beneficial effects of estrogen on leptin responsiveness in mice fed high fat diet: Role of estrogen receptor α and cytokines.


Keywords

  • Aging
  • Cytokines
  • ERα
  • Estrogen
  • Leptin sensitivity


Mitochondrial Dysfunction and Alpha-Lipoic Acid: Beneficial or Harmful in Alzheimer's Disease?


MeSH Terms

  • Aging
  • Alzheimer Disease
  • Amyloid beta-Peptides
  • Animals
  • Cytokines
  • Humans
  • Inflammation Mediators
  • Mitochondria
  • Neurofibrillary Tangles
  • Neurons
  • Neuroprotective Agents
  • Thioctic Acid


Design, synthesis and evaluation of diosgenin carbamate derivatives as multitarget anti-Alzheimer's disease agents.


MeSH Terms

  • Aging
  • Alzheimer Disease
  • Amyloid beta-Peptides
  • Animals
  • Anti-Inflammatory Agents, Non-Steroidal
  • Astrocytes
  • Carbamates
  • Cell Line, Tumor
  • Cell Survival
  • Diosgenin
  • Dose-Response Relationship, Drug
  • Drug Design
  • Galactose
  • Humans
  • Inflammation
  • Male
  • Mice
  • Mice, Inbred ICR
  • Molecular Structure
  • Neuroprotective Agents
  • Oxidative Stress
  • Protein Aggregates
  • Structure-Activity Relationship

Keywords

  • Alzheimer’s disease
  • Anti-Aβ activity
  • Anti-inflammatory
  • Antioxidant
  • Diosgenin
  • Multi-target-directed ligands


Oral Administration of Okara Soybean By-Product Attenuates Cognitive Impairment in a Mouse Model of Accelerated Aging.


MeSH Terms

  • Aging
  • Animal Feed
  • Animals
  • Brain-Derived Neurotrophic Factor
  • Cognitive Dysfunction
  • Diet
  • Gastrointestinal Microbiome
  • Gene Expression Regulation
  • Hippocampus
  • Male
  • Mice
  • Soybeans
  • Tumor Necrosis Factor-alpha

Keywords

  • BDNF
  • SAMP8
  • cognitive impairment
  • neuroprotection
  • okara


Electric vagal nerve stimulation inhibits inflammation and improves early postoperation cognitive dysfunction in aged rats.


MeSH Terms

  • Aging
  • Anesthesia, General
  • Animals
  • Behavior, Animal
  • Hippocampus
  • Inflammation
  • Male
  • Maze Learning
  • NF-kappa B
  • Postoperative Cognitive Complications
  • Rats
  • Rats, Sprague-Dawley
  • Splenectomy
  • Tumor Necrosis Factor-alpha
  • Vagus Nerve Stimulation

Keywords

  • Cognitive dysfunction
  • General anesthesia
  • Inflammation
  • Vagus nerve stimulation


Metformin decreases LPS-induced inflammatory response in rabbit annulus fibrosus stem/progenitor cells by blocking HMGB1 release.


MeSH Terms

  • Animals
  • Annulus Fibrosus
  • Anti-Inflammatory Agents
  • Cellular Senescence
  • HMGB1 Protein
  • Inflammation
  • Intervertebral Disc Degeneration
  • Lipopolysaccharides
  • Metformin
  • Rabbits
  • Stem Cells

Keywords

  • HMGB1
  • annulus fibrosis stem cells
  • cell senescence
  • intervertebral disc degeneration
  • metformin


The effects of blueberry and strawberry serum metabolites on age-related oxidative and inflammatory signaling in vitro.


MeSH Terms

  • Aged
  • Aging
  • Animals
  • Blueberry Plants
  • Double-Blind Method
  • Female
  • Fragaria
  • Fruit
  • Humans
  • Male
  • Microglia
  • Middle Aged
  • Nitric Oxide
  • Nitric Oxide Synthase Type II
  • Oxidative Stress
  • Postprandial Period
  • Rats
  • Tumor Necrosis Factor-alpha


Arsenic induces human chondrocyte senescence and accelerates rat articular cartilage aging.


Keywords

  • Aging
  • Arsenic
  • Articular cartilage
  • Human chondrocyte
  • Senescence
  • Senescence-associated secretory phenotype


Bone Benefits of Fish Oil Supplementation Depend on its EPA and DHA Content.


MeSH Terms

  • Age Factors
  • Animals
  • Bone Density
  • Bone Density Conservation Agents
  • Bone Marrow Cells
  • Bone Remodeling
  • Bone and Bones
  • Cells, Cultured
  • Cytokines
  • Dietary Supplements
  • Disease Models, Animal
  • Docosahexaenoic Acids
  • Eicosapentaenoic Acid
  • Female
  • JNK Mitogen-Activated Protein Kinases
  • Mice, Inbred C57BL
  • Osteoporosis
  • Signal Transduction
  • p38 Mitogen-Activated Protein Kinases

Keywords

  • aging
  • bone mineral density
  • bone resorption
  • concentrated fish oil
  • cytokines
  • inflammation
  • omega-3 fatty acids


Inflammaging phenotype in rhesus macaques is associated with a decline in epithelial barrier-protective functions and increased pro-inflammatory function in CD161-expressing cells.


MeSH Terms

  • Aging
  • Animals
  • Chronic Disease
  • Cytokines
  • Disease Models, Animal
  • Epithelium
  • Flow Cytometry
  • Immunity, Innate
  • Inflammation
  • Macaca mulatta
  • NK Cell Lectin-Like Receptor Subfamily B
  • Phenotype
  • Th17 Cells

Keywords

  • CD161+ cells
  • I-FABP
  • Inflammaging
  • LBP
  • Leaky gut
  • sCD14


Single-cell transcriptomics reveals expansion of cytotoxic CD4 T cells in supercentenarians.


MeSH Terms

  • Adult
  • Aged
  • Aged, 80 and over
  • B-Lymphocytes
  • CD4-Positive T-Lymphocytes
  • Case-Control Studies
  • Cell Differentiation
  • Cells, Cultured
  • Clonal Evolution
  • Gene Expression Profiling
  • Humans
  • Interferon-gamma
  • Leukocytes, Mononuclear
  • Middle Aged
  • Single-Cell Analysis
  • Tumor Necrosis Factor-alpha

Keywords

  • CD4 CTL
  • aging
  • centenarian
  • single-cell transcriptome


Gut microbiota combined with metabolomics reveals the metabolic profile of the normal aging process and the anti-aging effect of FuFang Zhenshu TiaoZhi(FTZ) in mice.


MeSH Terms

  • Aging
  • Animals
  • Bacteria
  • Biomarkers
  • Drugs, Chinese Herbal
  • Gastrointestinal Microbiome
  • Hyperlipidemias
  • Lipid Metabolism
  • Male
  • Metabolome
  • Metabolomics
  • Mice
  • Mice, Inbred C57BL

Keywords

  • Aging
  • FTZ
  • Gut microbiota
  • Metabolomics


Intervertebral disc ageing and degeneration: The antiapoptotic effect of oestrogen.


MeSH Terms

  • Aging
  • Animals
  • Apoptosis
  • Cytokines
  • Estrogens
  • Female
  • Humans
  • Inflammation
  • Intervertebral Disc
  • Intervertebral Disc Degeneration
  • Intervertebral Disc Displacement
  • Male
  • Phosphatidylinositol 3-Kinases
  • Signal Transduction

Keywords

  • Ageing
  • Apoptosis
  • Intervertebral disc degeneration
  • Oestrogen
  • Spine


MicroRNA 16-5p is upregulated in calorie-restricted mice and modulates inflammatory cytokines of macrophages.


MeSH Terms

  • Aging
  • Animals
  • Caloric Restriction
  • Cytokines
  • Diet Therapy
  • Inflammation
  • Interleukin-1beta
  • Macrophages
  • Male
  • Mice
  • Mice, Inbred C57BL
  • MicroRNAs
  • Models, Animal
  • RAW 264.7 Cells
  • Transcriptional Activation
  • Tumor Necrosis Factor-alpha
  • Up-Regulation

Keywords

  • Caloric restriction
  • Cellular immunology
  • Cytokines
  • Macrophages
  • microRNA


Aerobic exercise modulates cytokine profile and sleep quality in elderly.


MeSH Terms

  • Aged
  • Cytokines
  • Exercise
  • Female
  • Humans
  • Male
  • Middle Aged
  • Sedentary Behavior
  • Sleep Wake Disorders

Keywords

  • Sleep quality
  • aerobic exercise
  • aging
  • inflammatory cytokines


Trehalose targets Nrf2 signal to alleviate d-galactose induced aging and improve behavioral ability.


MeSH Terms

  • Aging
  • Animals
  • Disease Models, Animal
  • Dose-Response Relationship, Drug
  • Galactose
  • Male
  • Memory Disorders
  • Mice
  • Mice, Inbred ICR
  • NF-E2-Related Factor 2
  • Signal Transduction
  • Trehalose

Keywords

  • Antioxidant stress
  • Cognitive impairment
  • Inflammation
  • Nrf2
  • Trehalose
  • d-galactose


Anti-Inflammatory and Anti-Aging Evaluation of Pigment-Protein Complex Extracted from [i]Chlorella Pyrenoidosa[/i].


MeSH Terms

  • Aging
  • Animals
  • Anti-Inflammatory Agents
  • Antioxidants
  • Biological Products
  • Chlorella
  • Cytokines
  • Disease Models, Animal
  • Galactose
  • Inflammation
  • Interleukin-6
  • Lipopolysaccharides
  • Macrophages
  • Male
  • Mice
  • Mice, Inbred C57BL
  • NF-kappa B
  • Nitric Oxide
  • Oxidative Stress
  • RAW 264.7 Cells
  • Superoxide Dismutase
  • Tumor Necrosis Factor-alpha

Keywords

  • Chlorella pyrenoidosa
  • NF-κB
  • PPARs
  • anti-aging
  • anti-inflammation
  • pigment–protein complex


Inflammatory mediators and the risk of falls among older women with acute low back pain: data from Back Complaints in the Elders (BACE)-Brazil.


Keywords

  • Aging
  • BACE
  • Cytokines
  • Disability
  • Fall risk
  • Low back pain


Acetylcholinesterase inhibitors targeting the cholinergic anti-inflammatory pathway: a new therapeutic perspective in aging-related disorders.


Keywords

  • Acetylcholinesterase inhibitor
  • Aging
  • CHRFAM7A
  • CHRNA7
  • Cholinergic anti-inflammatory pathway
  • Neuroinflammation


Study on Metabolic Trajectory of Liver Aging and the Effect of Fufang Zhenzhu Tiaozhi on Aging Mice.


Keywords

  • Fufang Zhenzhu Tiaozhi
  • liver aging
  • mass spectrometry
  • metabolomics
  • ultra-performance liquid chromatography


Systemic Tumor Necrosis Factor-Alpha Trajectories Relate to Brain Health in Typically Aging Older Adults.


Keywords

  • Brain aging
  • Cognition
  • Gray matter volume
  • Inflammation
  • Neuroimaging


Targeting senescence improves angiogenic potential of adipose-derived mesenchymal stem cells in patients with preeclampsia.


MeSH Terms

  • Adipose Tissue
  • Adult
  • Cell Movement
  • Cell Proliferation
  • Cell Survival
  • Cellular Senescence
  • Dasatinib
  • Female
  • Humans
  • Mesenchymal Stem Cells
  • Pre-Eclampsia
  • Pregnancy
  • Protein Kinase Inhibitors

Keywords

  • Angiogenesis, Senolytics, Dasatinib
  • Mesenchymal stem cells
  • Preeclampsia
  • Senescence


Suppression of gut dysbiosis by Bifidobacterium longum alleviates cognitive decline in 5XFAD transgenic and aged mice.


MeSH Terms

  • Aging
  • Animals
  • Bifidobacterium longum
  • Cognitive Dysfunction
  • Dysbiosis
  • Feces
  • Gastrointestinal Microbiome
  • Humans
  • Lipopolysaccharides
  • Mice
  • Mice, Transgenic
  • Probiotics


Moderate hyperoxia induces senescence in developing human lung fibroblasts.


MeSH Terms

  • Autophagy
  • CCAAT-Enhancer-Binding Protein-beta
  • Cell Proliferation
  • Cellular Senescence
  • Cyclin-Dependent Kinase Inhibitor p21
  • DNA Damage
  • Endoplasmic Reticulum Stress
  • Etoposide
  • Extracellular Matrix
  • Fetus
  • Fibroblasts
  • G2 Phase Cell Cycle Checkpoints
  • Gene Expression Regulation
  • Humans
  • Hyperoxia
  • Interleukin-1
  • Interleukin-8
  • Lung
  • Matrix Metalloproteinase 3
  • Oxygen
  • Plasminogen Activator Inhibitor 1
  • Primary Cell Culture
  • Tumor Necrosis Factor-alpha
  • Tumor Suppressor Protein p53

Keywords

  • autophagy
  • endoplasmic reticulum stress
  • lung development
  • oxygen
  • senescence


Aging-related carcinoembryonic antigen-related cell adhesion molecule 1 signaling promotes vascular dysfunction.


MeSH Terms

  • Aged
  • Aging
  • Animals
  • Antigens, CD
  • Cell Adhesion Molecules
  • Cells, Cultured
  • Endothelium, Vascular
  • Humans
  • Mice
  • Mice, Inbred C57BL
  • Mice, Knockout
  • Middle Aged
  • Signal Transduction

Keywords

  • aging
  • anti-aging
  • cytokines
  • inflammation
  • mouse
  • reactive oxygen species


Microglia Express Insulin-Like Growth Factor-1 in the Hippocampus of Aged APP /PS1 Transgenic Mice.


Keywords

  • aging
  • cerebral amyloidosis
  • insulin-like growth factor
  • neurogenesis
  • neuroinflammation
  • tumor necrosis factor


Age- and diet-specific effects of chronic exposure to chlorpyrifos on hormones, inflammation and gut microbiota in rats.


MeSH Terms

  • Aging
  • Animals
  • Chlorpyrifos
  • Diet, High-Fat
  • Gastrointestinal Microbiome
  • Hypothalamo-Hypophyseal System
  • Inflammation
  • Male
  • Pituitary-Adrenal System
  • RNA, Ribosomal, 16S
  • Rats

Keywords

  • 16S rRNA gene sequencing
  • Gut endocrine
  • Gut-brain axis
  • Hormone
  • Hypothalamic-pituitary-adrenal axis
  • Inflammation

TOMM20[править]

Effect of aging on mitochondria and metabolism of bovine granulosa cells.


Keywords

  • Aging
  • Cow
  • Granulosa cells
  • Mitochondria

TP53[править]

p53 inhibits the osteogenic differentiation but does not induce senescence in human dental follicle cells.


Keywords

  • Cellular senescence
  • Dental follicle cells
  • E2F-1
  • Osteogenic differentiation
  • p53


Mutational spectrum and dynamics of clonal hematopoiesis in anemia of older individuals.


MeSH Terms

  • Age Factors
  • Aged
  • Aging
  • Anemia
  • Female
  • Hematopoiesis
  • Humans
  • Kaplan-Meier Estimate
  • Male
  • Middle Aged
  • Mutation
  • Prospective Studies


TP53/miR-34a-associated signaling targets [i]SERPINE1[/i] expression in human pancreatic cancer.


Keywords

  • Aging
  • PDAC
  • SERPINE1
  • TP53
  • cancer
  • miR-34a


Expression of p16 in nodular fasciitis: an implication for self-limited and inflammatory nature of the lesion.


Keywords

  • CDK4
  • MDM2
  • TP53
  • nodular fasciitis
  • p16
  • senescence

TPH1[править]

[i]Lactobacillus plantarum[/i] DR7 improved brain health in aging rats via the serotonin, inflammatory and apoptosis pathways.


Keywords

  • Lactobacillus spp.
  • aging
  • brain

TPO[править]

Megakaryocytes promote osteoclastogenesis in aging.


Keywords

  • aging
  • bone marrow macrophage
  • megakaryocyte
  • osteoclast
  • thrombopoietin

TPP1[править]

FBW7 Mediates Senescence and Pulmonary Fibrosis through Telomere Uncapping.


Keywords

  • DNA damage response
  • FBXW7
  • TPP1
  • cellular senescence
  • chronic stress
  • idiopathic pulmonary fibrosis
  • premature aging
  • proteostasis
  • stem cells
  • telomere
  • telomere uncapping

TPR[править]

Catalytic Performances of Cu/MCM-22 Zeolites with Different Cu Loadings in NH -SCR.


Keywords

  • Cu loading
  • Cu/MCM-22
  • NH3-SCR
  • hydrothermal aging


Do traits of plant species predict the efficacy of species distribution models for finding new occurrences?


Keywords

  • dispersal
  • generalist
  • lifespan
  • niche models
  • range size
  • specialist


In-situ modified the surface of Pt-doped perovskite catalyst for soot oxidation.


Keywords

  • Aging resistance
  • Amorphization
  • Surface modification
  • Symmetrical structure

TRAF3[править]

TRAF3, a Target of MicroRNA-363-3p, Suppresses Senescence and Regulates the Balance Between Osteoblastic and Adipocytic Differentiation of Rat Bone Marrow-Derived Mesenchymal Stem Cells.


Keywords

  • TRAF3
  • adipogenic differentiation
  • bone marrow-derived mesenchymal stem cells
  • miR-363-3p
  • osteogenic differentiation
  • senescence

TREM2[править]

Loss of TREM2 Confers Resilience to Synaptic and Cognitive Impairment in Aged Mice.


Keywords

  • TREM2
  • aging
  • dendritic spine density
  • learning and memory
  • long-term potentiation
  • synaptic plasticity


Triggering Receptor Expressed on Myeloid Cell 2 R47H Exacerbates Immune Response in Alzheimer's Disease Brain.


Keywords

  • NKG2D ligands
  • aging
  • inflammation
  • interferon type I response
  • microglia
  • neurodegeneration
  • senescence


Knockdown of astrocytic TREM2 in the hippocampus relieves cognitive decline in elderly male mice.


Keywords

  • Aging
  • Long-term potentiation
  • TREM2
  • astrocytes
  • learning and memory

TRIM21[править]

TRIM21 overexpression promotes tumor progression by regulating cell proliferation, cell migration and cell senescence in human glioma.


Keywords

  • Glioma
  • TRIM21
  • cell senescence
  • drug resistance
  • p53-p21 pathway
  • prognosis

TRIM27[править]

TRIM27 Functions as a Novel Oncogene in Non-Triple-Negative Breast Cancer by Blocking Cellular Senescence through p21 Ubiquitination.


Keywords

  • EP300
  • TRIM27
  • breast cancer
  • cell apoptosis
  • cell senescence
  • chemoresistance
  • p21
  • prognosis
  • transcription
  • ubiquitination

TRIP13[править]

BubR1 allelic effects drive phenotypic heterogeneity in mosaic-variegated aneuploidy progeria syndrome.


MeSH Terms

  • Aging
  • Alleles
  • Animals
  • Cell Cycle Proteins
  • Chromosome Disorders
  • Lung Neoplasms
  • Mice
  • Mice, Inbred C57BL
  • Mitosis
  • Mosaicism
  • Mutation
  • Phenotype
  • Progeria
  • Protein-Serine-Threonine Kinases

Keywords

  • Aging
  • Cancer
  • Cellular senescence
  • Genetic diseases
  • Oncology

TRPC6[править]

Redox and mTOR-dependent regulation of plasma lamellar calcium influx controls the senescence-associated secretory phenotype.


Keywords

  • SASP
  • Senescence
  • TRPC6
  • calcium
  • hydrogen peroxide
  • mTOR

TRPC7[править]

Nociceptive transient receptor potential canonical 7 (TRPC7) mediates aging-associated tumorigenesis induced by ultraviolet B.


Keywords

  • TRPC7
  • aging
  • p53
  • tumor initiator gene
  • tumorigenesis
  • ultraviolet pathology

TRPV4[править]

TRPV4 receptor as a functional sensory molecule in bladder urothelium: Stretch-independent, tissue-specific actions and pathological implications.


MeSH Terms

  • Animals
  • Calcium
  • Guinea Pigs
  • Humans
  • Muscle Contraction
  • Muscle, Smooth
  • TRPV Cation Channels
  • Urinary Bladder
  • Urothelium

Keywords

  • ATP release
  • TRPV4 receptor
  • aging
  • overactive bladders
  • urothelium


Exercise restores impaired endothelium-derived hyperpolarizing factor-mediated vasodilation in aged rat aortic arteries via the TRPV4-K 2.3 signaling complex.


MeSH Terms

  • Animals
  • Biological Factors
  • Cardiovascular Diseases
  • Endothelial Cells
  • Endothelium, Vascular
  • Male
  • Potassium Channels, Calcium-Activated
  • Rats
  • Rats, Sprague-Dawley
  • TRPV Cation Channels
  • Vasodilation

Keywords

  • EDHF
  • KCa2.3
  • TRPV4
  • aging
  • endothelium
  • exercise

TSPO[править]

Age and Sex Influence the Neuro-inflammatory Response to a Peripheral Acute LPS Challenge.


Keywords

  • 18 kDa translocator protein
  • aging
  • astrocytes
  • microglia
  • neuroinflammation
  • triggering receptor expressed on myeloid cells 2


Upregulation of cannabinoid receptor type 2, but not TSPO, in senescence-accelerated neuroinflammation in mice: a positron emission tomography study.


MeSH Terms

  • Aging
  • Animals
  • Brain
  • Inflammation
  • Mice
  • Microglia
  • Positron-Emission Tomography
  • Radiopharmaceuticals
  • Receptor, Cannabinoid, CB2
  • Receptors, GABA
  • Up-Regulation

Keywords

  • Cannabinoid receptor type 2
  • Immunostaining
  • Microglial activation
  • Positron emission tomography
  • Senescence-accelerated prone mouse
  • Translocator protein

TST[править]

H S Donors Reverse Age-Related Gastric Malfunction Impaired Due to Fructose-Induced Injury [i]via[/i] CBS, CSE, and TST Expression.


Keywords

  • aging
  • donor
  • fructose
  • gastric mucosa
  • hydrogen sulfide
  • oxidative stress


Adaptations in mechanical muscle function, muscle morphology, and aerobic power to high-intensity endurance training combined with either traditional or power strength training in older adults: a randomized clinical trial.


Keywords

  • Aging
  • Concurrent training
  • Explosive force
  • Functional capacity
  • HIIT


Digital phenotyping by consumer wearables identifies sleep-associated markers of cardiovascular disease risk and biological aging.


MeSH Terms

  • Adult
  • Aged
  • Aging
  • Body Mass Index
  • Cardiovascular Diseases
  • Cohort Studies
  • Female
  • Humans
  • Male
  • Middle Aged
  • Risk Factors
  • Self Report
  • Sleep
  • Telomere
  • Waist Circumference
  • Wearable Electronic Devices
  • Young Adult

Keywords

  • Data integration
  • Predictive markers
  • Risk factors
  • Senescence


Objective Sleep Duration in Older Adults: Results From The Irish Longitudinal Study on Ageing.


MeSH Terms

  • Accelerometry
  • Aged
  • Aging
  • Cross-Sectional Studies
  • Exercise
  • Female
  • Health Status
  • Humans
  • Independent Living
  • Ireland
  • Longitudinal Studies
  • Male
  • Polysomnography
  • Self Report
  • Sleep
  • Time Factors

Keywords

  • GENEActiv
  • accelerometer
  • actigraphy
  • older population
  • sleep duration

TTL[править]

Longitudinal Associations of Body Mass Index, Waist Circumference, and Waist-to-Hip Ratio with Biomarkers of Oxidative Stress in Older Adults: Results of a Large Cohort Study.


MeSH Terms

  • Aged
  • Aged, 80 and over
  • Aging
  • Biomarkers
  • Body Mass Index
  • Cohort Studies
  • Female
  • Germany
  • Humans
  • Longitudinal Studies
  • Male
  • Middle Aged
  • Oxidative Stress
  • Waist Circumference
  • Waist-Hip Ratio

Keywords

  • Body mass index
  • Free radicals
  • Oxidative stress
  • Reactive oxygen metabolites
  • Total thiol levels
  • Waist circumference
  • Waist-to-hip ratio

TTN[править]

LncRNA TTN-AS1 regulates osteosarcoma cell apoptosis and drug resistance via the miR-134-5p/MBTD1 axis.


MeSH Terms

  • Aging
  • Apoptosis
  • Brain Neoplasms
  • Cell Line, Tumor
  • Cell Proliferation
  • Chromosomal Proteins, Non-Histone
  • Computational Biology
  • Drug Resistance
  • Gene Expression Regulation, Neoplastic
  • Humans
  • MicroRNAs
  • Osteosarcoma
  • RNA, Long Noncoding

Keywords

  • aging and age-related diseases
  • lncRNA TTN-AS1
  • malignant brain tumour domain containing protein 1
  • miR-134-5p
  • osteosarcoma
  • resistance

TTR[править]

Cellular secretion and cytotoxicity of transthyretin mutant proteins underlie late-onset amyloidosis and neurodegeneration.


MeSH Terms

  • Amyloid Neuropathies, Familial
  • Animals
  • Cell Death
  • Cell Line, Tumor
  • Disease Models, Animal
  • Drosophila
  • HEK293 Cells
  • Humans
  • Locomotion
  • Longevity
  • Mutant Proteins
  • Mutation
  • Nerve Degeneration
  • Prealbumin

Keywords

  • Amyloidosis
  • Drosophila melanogaster
  • ERQC
  • Endoplasmic reticulum quality control
  • Proteostasis
  • TTR
  • Transthyretin

TXNIP[править]

Panax notoginseng saponins attenuate neuroinflammation through TXNIP-mediated NLRP3 inflammasome activation in aging rats.


Keywords

  • Aging
  • Microglia
  • NLRP3 inflammasome
  • Saponins from Panax notoginseng.
  • TXNIP
  • neuroinflammation


Redox homeostasis and cell cycle activation mediate beta-cell mass expansion in aged, diabetes-prone mice under metabolic stress conditions: Role of thioredoxin-interacting protein (TXNIP).


Keywords

  • Aging
  • Beta-cells
  • Cell cycle
  • Metabolic stress
  • Redox homeostasis
  • Thioredoxin-interacting protein


[Effect of diabetic induced thioredoxin interacting protein (TXNIP) on islet cell senescence].


MeSH Terms

  • Animals
  • Carrier Proteins
  • Cellular Senescence
  • Diabetes Mellitus, Experimental
  • Islets of Langerhans
  • Mice
  • Thioredoxins

Keywords

  • INS-1 cell
  • cell senescence
  • diabetes
  • thioredoxin interacting protein


PRMT5-TRIM21 interaction regulates the senescence of osteosarcoma cells by targeting the TXNIP/p21 axis.


Keywords

  • PRMT5
  • TRIM21
  • TXNIP
  • p21
  • senescence

TXNRD2[править]

Wogonin induces cellular senescence in breast cancer via suppressing TXNRD2 expression.


Keywords

  • Breast cancer
  • Immune surveillance
  • ROS
  • Senescence
  • TXNRD2
  • Wogonin

U2AF1[править]

Isobaric tags for relative and absolute quantitation (iTRAQ)-based proteomic analysis of mRNA splicing relevant proteins in aging HSPCs.


Keywords

  • Aging
  • DEPs
  • HSPC
  • iTRAQ
  • mRNA splicing

UACA[править]

Knockdown of [i]UACA[/i] inhibitsproliferation and invasion and promotes senescence of hepatocellular carcinoma cells.


Keywords

  • HIF1α
  • UACA
  • hepatocellular carcinoma
  • invasion
  • knockdown
  • proliferation
  • senescence

UCHL1[править]

Abolishing UCHL1's hydrolase activity exacerbates TBI-induced axonal injury and neuronal death in mice.


Keywords

  • Aging
  • Axonal injury
  • Neurodegeneration
  • Traumatic brain injury
  • Ubiquitin carboxy terminal hydrolase L1
  • Ubiquitin proteasome pathway

UCP1[править]

Muscle-dependent regulation of adipose tissue function in long-lived growth hormone-mutant mice.


Keywords

  • adipose tissue
  • aging
  • growth hormone
  • inflammation
  • uncoupling protein 1 (UCP1)


Lack of UCP1 stimulates fatty liver but mediates UCP1-independent action of beige fat to improve hyperlipidemia in Apoe knockout mice.


Keywords

  • Apoe knockout mice
  • Beige fat
  • Gene expression
  • Hyperlipidemia
  • Longevity
  • Uncoupling protein 1


Postnatal leptin surge is critical for the transient induction of the developmental beige adipocytes in mice.


MeSH Terms

  • Adipocytes, Beige
  • Adipocytes, White
  • Adipose Tissue
  • Aging
  • Animals
  • Dose-Response Relationship, Drug
  • Female
  • Leptin
  • Male
  • Mice
  • Mice, Obese
  • Sympathetic Nervous System
  • Tyrosine 3-Monooxygenase
  • Uncoupling Protein 1

Keywords

  • beige adipocytes
  • leptin
  • sympathetic nerve system


Age-related sex differences in the expression of important disease-linked mitochondrial proteins in mice.


MeSH Terms

  • Adipose Tissue, Brown
  • Aging
  • Animals
  • Brain
  • Female
  • Male
  • Mice, Inbred C57BL
  • Mitochondrial Proteins
  • Muscle, Skeletal
  • Sex Characteristics
  • Spleen


An anti-inflammatory phenotype in visceral adipose tissue of old lean mice, augmented by exercise.


MeSH Terms

  • Adipocytes
  • Aging
  • Animals
  • Humans
  • Inflammation
  • Intra-Abdominal Fat
  • Macrophages
  • Mice
  • Obesity
  • Phenotype
  • Physical Conditioning, Animal
  • Resistance Training

UGT2B28[править]

Ages of hepatocellular carcinoma occurrence and life expectancy are associated with a UGT2B28 genomic variation.


MeSH Terms

  • Adult
  • Age of Onset
  • Aged
  • Aged, 80 and over
  • Carcinoma, Hepatocellular
  • Female
  • Genetic Association Studies
  • Genetic Predisposition to Disease
  • Glucuronosyltransferase
  • Humans
  • Life Expectancy
  • Liver Neoplasms
  • Male
  • Middle Aged
  • Neoplasm Metastasis
  • Neoplasm Recurrence, Local
  • Odds Ratio
  • Polymorphism, Single Nucleotide
  • Survival Analysis
  • Young Adult

Keywords

  • Alcoholism
  • Xenobiotic metabolizing enzymes
  • Young hepatocellular carcinoma; age of death

USP7[править]

Deubiquitinase USP7 regulates [i]Drosophila[/i] aging through ubiquitination and autophagy.


Keywords

  • DMC
  • Drosophila
  • USP7
  • aging
  • autophagy

VCAM1[править]

Sunitinib facilitates metastatic breast cancer spreading by inducing endothelial cell senescence.


Keywords

  • Cell senescence
  • Metastasis
  • Metastatic breast cancer (MBC)
  • Receptor tyrosine kinase (RTK)
  • Sunitinib

VDAC1[править]

Low abundance of NDUFV2 and NDUFS4 subunits of the hydrophilic complex I domain and VDAC1 predicts mammalian longevity.


Keywords

  • Complex I
  • Droplet digital PCR
  • Longevity
  • Mammals
  • Mitochondria
  • NDUFS4 subunit
  • NDUFV2 subunit
  • VDAC
  • Western blot


Changes in the expression of oxidative phosphorylation complexes in the aging intestinal mucosa.


Keywords

  • Aging
  • Colonic crypt
  • Expression
  • Intestine
  • Mitochondria
  • OXPHOS

VDR[править]

25-Hydroxyvitamin D positively regulates periodontal inflammaging via SOCS3/STAT signaling in diabetic mice.


Keywords

  • 25-Hydroxyvitamin D(3)
  • Diabetic periodontitis
  • Inflammaging
  • SOCS3
  • Senescence
  • Senescence-associated secretory phenotypes


1,25-Dihydroxyvitamin D protects against age-related osteoporosis by a novel VDR-Ezh2-p16 signal axis.


MeSH Terms

  • 25-Hydroxyvitamin D3 1-alpha-Hydroxylase
  • Aging
  • Animals
  • Bone and Bones
  • Cells, Cultured
  • Cyclin-Dependent Kinase Inhibitor p16
  • Cyclin-Dependent Kinase Inhibitor p19
  • DNA Damage
  • Enhancer of Zeste Homolog 2 Protein
  • Female
  • Histones
  • Male
  • Mesenchymal Stem Cells
  • Mice
  • Mice, Knockout
  • Osteocytes
  • Osteogenesis
  • Osteoporosis
  • Oxidative Stress
  • Receptors, Calcitriol
  • Vitamin D

Keywords

  • Ezh2
  • Vitamin D
  • cellular senescence
  • osteogenesis
  • osteoporosis
  • p16


Active vitamin D impedes the progression of non-alcoholic fatty liver disease by inhibiting cell senescence in a rat model.


Keywords

  • Active vitamin D
  • Cell senescence
  • Non-alcoholic fatty liver disease
  • Oxidative stress
  • P53-p21 signaling pathway
  • Vitamin D receptor

VEGFA[править]

APOE ε4-specific associations of VEGF gene family expression with cognitive aging and Alzheimer's disease.


MeSH Terms

  • Aged
  • Aged, 80 and over
  • Aging
  • Apolipoprotein E4
  • Cognitive Aging
  • Cognitive Dysfunction
  • Female
  • Gene Expression
  • Genetic Association Studies
  • Genetic Predisposition to Disease
  • Genotype
  • Humans
  • Male
  • Neovascularization, Physiologic
  • Neuropilin-1
  • Vascular Endothelial Growth Factor A

Keywords

  • APOE-ε4
  • Aging
  • Cognition
  • Gene expression
  • Vascular endothelial growth factor (VEGF)

VGLL4[править]

The lncRNA MEG3/miR-16-5p/VGLL4 regulatory axis is involved in etoposide-induced senescence of tumor cells.


Keywords

  • LncRNA MEG3
  • breast cancer
  • cell senescence
  • etoposide
  • lung adenocarcinoma

VHL[править]

Hypoxic response regulators RHY-1 and EGL-9/PHD promote longevity through a VHL-1-independent transcriptional response.


Keywords

  • Aging
  • C. elegans
  • EGL-9/PHD
  • HIF-1 signaling
  • Hypoxic response
  • Lifespan
  • RHY-1

VIM[править]

Establishment and characterization of a fibroblast cell line from postmortem skin of an adult Chinese muntjac (Muntiacus reevesi).


MeSH Terms

  • Aging
  • Animals
  • Cell Culture Techniques
  • Cell Line
  • Cell Proliferation
  • Cell Shape
  • Chromosomes, Mammalian
  • Fibroblasts
  • Male
  • Muntjacs
  • Postmortem Changes
  • Skin

Keywords

  • Characteristics
  • Chinese muntjac
  • Fibroblast cell line
  • Postmortem skin

VIP[править]

Alterations in Intrinsic and Synaptic Properties of Hippocampal CA1 VIP Interneurons During Aging.


Keywords

  • VIP
  • action potential
  • aging
  • calretinin
  • circuit disinhibition
  • hippocampus
  • synapse


Nutrition and exercise interventions could ameliorate age-related cognitive decline: a meta-analysis of randomized controlled trials.


Keywords

  • Aging
  • Cognitive impairment
  • Exercise
  • Meta-analysis
  • Nutrition

VSIG4[править]

Immune checkpoint protein VSIG4 as a biomarker of aging in murine adipose tissue.


Keywords

  • VSIG4
  • adipose tissue
  • aging
  • frailty index
  • immune checkpoint
  • inflammation
  • macrophage
  • mouse

WASL[править]

Loss of Wasl improves pancreatic cancer outcome.


Keywords

  • Cancer
  • Cellular senescence
  • Mouse models
  • Oncology

WDR5[править]

Inhibition of the H3K4 methyltransferase MLL1/WDR5 complex attenuates renal senescence in ischemia reperfusion mice by reduction of p16 .


MeSH Terms

  • Acute Kidney Injury
  • Animals
  • Biphenyl Compounds
  • Cell Line
  • Cyclin-Dependent Kinase Inhibitor p16
  • Dihydropyridines
  • Drug Evaluation, Preclinical
  • Fibroblasts
  • Histone-Lysine N-Methyltransferase
  • Histones
  • Intracellular Signaling Peptides and Proteins
  • Male
  • Mice, Inbred C57BL
  • Myeloid-Lymphoid Leukemia Protein
  • Rats
  • Renal Insufficiency
  • Reperfusion Injury

Keywords

  • H3K4me3
  • MLL1
  • WDR5
  • acute kidney injury
  • p16(INK4a)
  • senescence

WFDC2[править]

Differences in biomarkers and molecular pathways according to age for patients with HFrEF.


Keywords

  • aging
  • biological age
  • biomarkers
  • chronological age
  • heart failure with reduced ejection fraction

WIPI2[править]

Neuronal autophagy declines substantially with age and is rescued by overexpression of WIPI2.


MeSH Terms

  • Aging
  • Animals
  • Autophagy
  • Autophagy-Related Proteins
  • Mice, Transgenic
  • Models, Biological
  • Neurons
  • Phagosomes
  • Phosphate-Binding Proteins
  • RNA, Messenger

Keywords

  • Aging
  • WIPI2
  • autophagosome biogenesis
  • autophagy
  • macroautophagy
  • neurodegeneration
  • neuronal autophagy

WNT1[править]

Plasma proteomic profile of age, health span, and all-cause mortality in older adults.


Keywords

  • SomaScan® assay
  • aging
  • proteomics
  • weighted gene co-expression network analysis

WNT10A[править]

Dysregulation of the Wnt Signaling Pathway and Synovial Stem Cell Dysfunction in Osteoarthritis Development.


Keywords

  • Wnt signaling pathway
  • cell senescence
  • differentiation
  • osteoarthritis
  • synovial mesenchymal stem cells (SMSCs)

WNT3A[править]

Chronic WNT/β-catenin signaling induces cellular senescence in lung epithelial cells.


Keywords

  • ATII cells
  • Aging
  • Cellular senescence
  • IPF
  • WNT signaling

WNT7A[править]

Exogenous Expression of WNT7A in Leukemia-Derived Cell Lines Induces Resistance to Chemotherapeutic Agents.


Keywords

  • WNT signaling
  • WNT7A
  • cell cycle
  • chemotherapeutic agents
  • leukemias
  • senescence

WRN[править]

The Impact of Vitamin C on Different System Models of Werner Syndrome.


Keywords

  • Werner syndrome
  • aging
  • mouse
  • stem cells
  • vitamin C
  • worm


WRN modulates translation by influencing nuclear mRNA export in HeLa cancer cells.


Keywords

  • Cancer
  • NXF1 export receptor
  • Senescence
  • Translation
  • Werner syndrome protein
  • mRNA export


MIB1-mediated degradation of WRN promotes cellular senescence in response to camptothecin treatment.


Keywords

  • CPT
  • Mind bomb 1
  • Werner syndrome protein
  • aging
  • protein stability


A Case Report of Werner's Syndrome With a Novel Mutation From India.


Keywords

  • aging
  • novel mutation
  • progeria
  • werner syndrome
  • wrn gene


Evidence for premature aging in a Drosophila model of Werner syndrome.


MeSH Terms

  • Aging, Premature
  • Animals
  • Behavior, Animal
  • Body Composition
  • Body Weight
  • DNA Repair
  • Drosophila
  • Drosophila Proteins
  • Exonucleases
  • Female
  • Gastrointestinal Neoplasms
  • Male
  • Motor Activity
  • Muscle Weakness
  • Mutation
  • Phenotype
  • Werner Syndrome

Keywords

  • Aging
  • DNA repair
  • Locomotor function
  • Tumor
  • Werner syndrome

WT1[править]

Age and weight at first mating affects plasma leptin concentration but no effects on reproductive performance of gilts.


Keywords

  • Backfat
  • Gilts
  • Leptin
  • Litter performance
  • Longevity
  • Mating

WWP1[править]

The ubiquitin ligase WWP1 contributes to shifts in matrix proteolytic profiles and a myocardial aging phenotype with diastolic heart.


MeSH Terms

  • Age Factors
  • Animals
  • Cells, Cultured
  • Diastole
  • Disease Models, Animal
  • Extracellular Matrix
  • Female
  • Fibroblasts
  • Heart Failure
  • Hypertrophy, Left Ventricular
  • Male
  • Mice, Inbred C57BL
  • Mice, Transgenic
  • Myocardium
  • Phenotype
  • Proteolysis
  • Stroke Volume
  • Ubiquitin-Protein Ligases
  • Ventricular Dysfunction, Left
  • Ventricular Function, Left
  • Ventricular Remodeling

Keywords

  • aging
  • cardiac hypertrophy
  • diastolic dysfunction
  • heart failure
  • ventricular remodeling

XBP1[править]

Age-dependent impairment of adipose-derived stem cells isolated from horses.


Keywords

  • Aging
  • Endoplasmic reticulum stress
  • Equine adipose-derived mesenchymal stem cells
  • Insulin resistance
  • Pro-inflammatory cytokines

XDH[править]

Enhancing xanthine dehydrogenase activity is an effective way to delay leaf senescence and increase rice yield.


Keywords

  • Allantoin
  • Reactive oxygen species
  • Rice (Oryza sativa L.)
  • Senescence
  • Xanthine dehydrogenase
  • Yield

ZC3H12A[править]

Keratinocyte-specific ablation of Mcpip1 impairs skin integrity and promotes local and systemic inflammation.


MeSH Terms

  • Aging
  • Animals
  • Calgranulin A
  • Cell Differentiation
  • Cell Proliferation
  • Cells, Cultured
  • Cornified Envelope Proline-Rich Proteins
  • Epidermis
  • Gene Expression Regulation
  • Gene Ontology
  • Inflammation
  • Interleukin-1
  • Keratinocytes
  • Keratins
  • Lymph Nodes
  • Mice
  • Mice, Inbred C57BL
  • Mice, Transgenic
  • Proliferating Cell Nuclear Antigen
  • Ribonucleases
  • Skin
  • Spleen
  • Transcriptome

Keywords

  • MCPIP1
  • Regnase-1
  • Skin inflammation
  • ZC3H12A

ZEB2[править]

miR-200b regulates cellular senescence and inflammatory responses by targeting ZEB2 in pulmonary emphysema.


MeSH Terms

  • Animals
  • Cell Line
  • Cellular Senescence
  • Disease Models, Animal
  • Gene Expression
  • Gene Expression Regulation
  • Inflammation
  • Lung
  • Mice
  • MicroRNAs
  • Pulmonary Emphysema
  • Zinc Finger E-box Binding Homeobox 2

Keywords

  • ZEB2
  • cellular senescence
  • inflammation
  • miR-200b
  • pulmonary emphysema

ZMPSTE24[править]

Bone marrow-derived mesenchymal stem cells in three-dimensional co-culture attenuate degeneration of nucleus pulposus cells.


MeSH Terms

  • Bone Marrow Cells
  • Cell Cycle
  • Cell Proliferation
  • Cell Survival
  • Cells, Cultured
  • Cellular Senescence
  • Coculture Techniques
  • Collagen Type II
  • Female
  • Humans
  • Intervertebral Disc Degeneration
  • Male
  • Matrix Metalloproteinase 9
  • Membrane Proteins
  • Mesenchymal Stem Cells
  • Metalloendopeptidases
  • Middle Aged
  • Nucleus Pulposus
  • Signal Transduction
  • Transcription Factor RelA
  • Up-Regulation
  • beta-Galactosidase

Keywords

  • 3D co-culture
  • ZMPSTE24
  • bone marrow-derived mesenchymal stem cells
  • nucleus pulposus
  • senescence
Источник — https://transhumanist.ru/index.php?title=Публикации_о_генах_и_старении_(titles)&oldid=2650