Aging genes 1-2

ABCA1

Intracellular cholesterol stimulates ENaC by interacting with phosphatidylinositol‑4,5‑bisphosphate and mediates cyclosporine A-induced hypertension. / 01.07.2019 / PubMed / Full text
Disrupted cholesterol metabolism promotes age-related photoreceptor neurodegeneration. / 08.2018 / PubMed / Full text

ACACA

Expression of lipogenic markers is decreased in subcutaneous adipose tissue and adipocytes of older women and is negatively linked to GDF15 expression. / 08.2019 / PubMed / Full text
GH prevents adipogenic differentiation of mesenchymal stromal stem cells derived from human trabecular bone via canonical Wnt signaling. / 07.2018 / PubMed / Full text

ACAT1

An Adult Drosophila Glioma Model for Studying Pathometabolic Pathways of Gliomagenesis. / 06.2019 / PubMed / Full text
Serum starvation of ARPE-19 changes the cellular distribution of cholesterol and Fibulin3 in patterns reminiscent of age-related macular degeneration. / 15.12.2017 / PubMed / Full text

ACOX1

Dietary methionine increased the lipid accumulation in juvenile tiger puffer Takifugu rubripes. / 04.2019 / PubMed / Full text
Peroxisomal Acyl-CoA Oxidase Type 1: Anti-Inflammatory and Anti-Aging Properties with a Special Emphasis on Studies with LPS and Argan Oil as a Model Transposable to Aging. / 2018 / PubMed / Full text

ACTA1

Explaining meat quality of bulls and steers by differential proteome and phosphoproteome analysis of skeletal muscle. / 15.05.2019 / PubMed / Full text
Serum starvation of ARPE-19 changes the cellular distribution of cholesterol and Fibulin3 in patterns reminiscent of age-related macular degeneration. / 15.12.2017 / PubMed / Full text

ACTB

Selection of a Real-Time PCR Housekeeping Gene Panel in Human Endothelial Colony Forming Cells for Cellular Senescence Studies. / 2019 / PubMed / Full text
WNT-activated bone grafts repair osteonecrotic lesions in aged animals. / 27.10.2017 / PubMed / Full text

ADAM17

ACE2/ADAM17/TMPRSS2 Interplay May Be the Main Risk Factor for COVID-19. / 2020 / PubMed / Full text
DNA methylation analysis on purified neurons and glia dissects age and Alzheimer's disease-specific changes in the human cortex. / 25.07.2018 / PubMed / Full text

ADH5

Can Serum Nitrosoproteome Predict Longevity of Aged Women? / 27.11.2020 / PubMed / Full text
Denitrosylate and live longer: how ADH5/GSNOR links mitophagy to aging. / 2018 / PubMed / Full text

AGER

Vitamin D3 regulates apoptosis and proliferation in the testis of D-galactose-induced aged rat model. / 01.10.2019 / PubMed / Full text
Long-lived rodents reveal signatures of positive selection in genes associated with lifespan. / 03.2018 / PubMed / Full text

AGO2

Profiling of m6A RNA modifications identified an age-associated regulation of AGO2 mRNA stability. / 06.2018 / PubMed / Full text
miRNA processing gene polymorphisms, blood DNA methylation age and long-term ambient PM exposure in elderly men. / 12.2017 / PubMed / Full text

AGT

SQSTM1/p62 and PPARGC1A/PGC-1alpha at the interface of autophagy and vascular senescence. / 06.2020 / PubMed / Full text
Towards frailty biomarkers: Candidates from genes and pathways regulated in aging and age-related diseases. / 11.2018 / PubMed / Full text

ALKBH8

Loss of epitranscriptomic control of selenocysteine utilization engages senescence and mitochondrial reprogramming . / 01.2020 / PubMed / Full text
ALKB-8, a 2-Oxoglutarate-Dependent Dioxygenase and S-Adenosine Methionine-Dependent Methyltransferase Modulates Metabolic Events Linked to Lysosome-Related Organelles and Aging in C. elegans. / 2018 / PubMed

AMT

A multi-method comparison of autobiographical memory impairments amongst younger and older adults. / 12.03.2020 / PubMed / Full text
Autobiographical Memory From Different Life Stages in Individuals With Obstructive Sleep Apnea. / 03.2019 / PubMed / Full text

ANGPTL2

Circulating angiopoietin-like protein 2 levels and mortality risk in patients receiving maintenance hemodialysis: a prospective cohort study. / 01.05.2020 / PubMed / Full text
Age-dependent increase in angiopoietin-like protein 2 accelerates skeletal muscle loss in mice. / 02.02.2018 / PubMed / Full text

ANK1

Alzheimer's Disease Associated Genes Ankyrin and Tau Cause Shortened Lifespan and Memory Loss in [i]Drosophila[/i]. / 2019 / PubMed / Full text
DNA methylation analysis on purified neurons and glia dissects age and Alzheimer's disease-specific changes in the human cortex. / 25.07.2018 / PubMed / Full text

APOA5

Critical Role of SREBP-1c Large-VLDL Pathway in Environment-Induced Hypertriglyceridemia of Apo AV Deficiency. / 03.2019 / PubMed / Full text
Longitudinal interaction between APOA5 -1131T>C and overweight in the acceleration of age-related increase in arterial stiffness through the regulation of circulating triglycerides. / 02.2019 / PubMed / Full text

APPL2

The reversal effect of physical exercise on aging-related increases in APPL2 content in skeletal muscle. / 01.10.2018 / PubMed / Full text
Adaptor Protein APPL2 Affects Adult Antidepressant Behaviors and Hippocampal Neurogenesis via Regulating the Sensitivity of Glucocorticoid Receptor. / 07.2018 / PubMed / Full text

AQP1

Blue Light Induces Down-Regulation of Aquaporin 1, 3, and 9 in Human Keratinocytes. / 03.11.2018 / PubMed / Full text
[Age-related changes of water transport by corneal endothelial cells in rats.] / 2017 / PubMed

AQP3

Transbuccal platform for delivery of lipogenic actives to facial skin: Because fat matters. / 08.2020 / PubMed / Full text
[Age-related changes of water transport by corneal endothelial cells in rats.] / 2017 / PubMed

AREG

Targeting amphiregulin (AREG) derived from senescent stromal cells diminishes cancer resistance and averts programmed cell death 1 ligand (PD-L1)-mediated immunosuppression. / 12.2019 / PubMed / Full text
Regulatory T-cells regulate neonatal heart regeneration by potentiating cardiomyocyte proliferation in a paracrine manner. / 2019 / PubMed / Full text

ARID1A

Oncogenic mutations in histologically normal endometrium: the new normal? / 10.2019 / PubMed / Full text
ARID1A suppresses malignant transformation of human pancreatic cells via mediating senescence-associated miR-503/[[CDKN2A]] regulatory axis. / 18.11.2017 / PubMed / Full text

ATG12

Lifelong Football Training: Effects on Autophagy and Healthy Longevity Promotion. / 2019 / PubMed / Full text
SIRT6 histone deacetylase functions as a potential oncogene in human melanoma. / 09.2017 / PubMed / Full text

ATG3

Estrogen Signaling Induces Mitochondrial Dysfunction-Associated Autophagy and Senescence in Breast Cancer Cells. / 01.04.2020 / PubMed / Full text
SIRT6 histone deacetylase functions as a potential oncogene in human melanoma. / 09.2017 / PubMed / Full text

ATG9A

SIRT1 protects cochlear hair cell and delays age-related hearing loss via autophagy. / 08.2019 / PubMed / Full text
Activation of miR-34a impairs autophagic flux and promotes cochlear cell death via repressing ATG9A: implications for age-related hearing loss. / 05.10.2017 / PubMed / Full text

ATP7A

Adipocyte-specific disruption of ATPase copper transporting α in mice accelerates lipoatrophy. / 12.2019 / PubMed / Full text
TAp73 regulates ATP7A: possible implications for ageing-related diseases. / 08.12.2018 / PubMed / Full text

B2M

The relationships between markers of tubular injury and intrarenal haemodynamic function in adults with and without type 1 diabetes: Results from the Canadian Study of Longevity in Type 1 Diabetes. / 03.2019 / PubMed / Full text
Association between serum β2-microglobulin levels and frailty in an elderly Chinese population: results from RuLAS. / 2017 / PubMed / Full text

B4GALT1

Expression of β-1,4-galactosyltransferases during Aging in Caenorhabditis elegans. / 2020 / PubMed / Full text
Glycobiology of Aging. / 2018 / PubMed / Full text

BAK1

Developmental Attenuation of Neuronal Apoptosis by Neural-Specific Splicing of Bak1 Microexon. / 23.09.2020 / PubMed / Full text
SIRT6 histone deacetylase functions as a potential oncogene in human melanoma. / 09.2017 / PubMed / Full text

BCL6

Ecto-NTPDase CD39 is a negative checkpoint that inhibits follicular helper cell generation. / 01.07.2020 / PubMed / Full text
Transcription factor networks in aged naïve CD4 T cells bias lineage differentiation. / 08.2019 / PubMed / Full text

BECN1

Calpain-dependent Beclin1 cleavage stimulates senescence-associated cell death in HT22 hippocampal cells under the oxidative stress conditions. / 14.05.2019 / PubMed / Full text
Autophagy regulates the degeneration of the auditory cortex through the AMPK-mTOR-ULK1 signaling pathway. / 04.2018 / PubMed / Full text

BGN

Alterations of local functional connectivity in lifespan: A resting-state fMRI study. / 07.2020 / PubMed / Full text
Exploring variability in basal ganglia connectivity with functional MRI in healthy aging. / 12.2018 / PubMed / Full text

BIN1

Amphiphysin 2 modulation rescues myotubular myopathy and prevents focal adhesion defects in mice. / 20.03.2019 / PubMed / Full text
Recent studies on cellular and molecular mechanisms in Alzheimer's disease: focus on epigenetic factors and histone deacetylase. / 28.03.2018 / PubMed / Full text

BMF

lncRNA-ES3/miR-34c-5p/BMF axis is involved in regulating high-glucose-induced calcification/senescence of VSMCs. / 17.01.2019 / PubMed / Full text
Aging, hematopoiesis, and the myelodysplastic syndromes. / 08.12.2017 / PubMed / Full text

BMP15

Antioxidant hesperetin improves the quality of porcine oocytes during aging in vitro. / 01.2019 / PubMed / Full text
Observation of the influences of diosgenin on aging ovarian reserve and function in a mouse model. / 18.10.2017 / PubMed / Full text

BNIP3

Late life maintenance and enhancement of functional exercise capacity in low and high responding rats after low intensity treadmill training. / 01.10.2019 / PubMed / Full text
Regulation of apoptosis and autophagy in mouse and human skeletal muscle with aging and lifelong exercise training. / 01.10.2018 / PubMed / Full text

BTK

Amelioration of age-related brain function decline by Bruton's tyrosine kinase inhibition. / 01.2020 / PubMed / Full text
BTK suppresses myeloma cellular senescence through activating AKT/P27/Rb signaling. / 22.08.2017 / PubMed / Full text

C9orf72

Carriership of two copies of C9orf72 hexanucleotide repeat intermediate-length alleles is a risk factor for ALS in the Finnish population. / 09.11.2020 / PubMed / Full text
C9orf72 Dipeptide Repeats Cause Selective Neurodegeneration and Cell-Autonomous Excitotoxicity in [i]Drosophila[/i] Glutamatergic Neurons. / 29.08.2018 / PubMed / Full text

CAST

Cytomatrix proteins CAST and ELKS regulate retinal photoreceptor development and maintenance. / 05.11.2018 / PubMed / Full text
Short Telomeres Induce p53 and Autophagy and Modulate Age-Associated Changes in Cardiac Progenitor Cell Fate. / 06.2018 / PubMed / Full text

CBL

Effects of cerebrolysin on nerve growth factor system in the aging rat brain. / 2017 / PubMed / Full text
Skeletal Muscle CAP Expression Increases after Dietary Restriction and Aerobic Training in Women with a History of Gestational Diabetes. / 2016 / PubMed / Full text

CCL17

Aging and chronic high-fat feeding negatively affects kidney size, function, and gene expression in CTRP1-deficient mice. / 21.10.2020 / PubMed / Full text
Senescent thyrocytes and thyroid tumor cells induce M2-like macrophage polarization of human monocytes via a PGE2-dependent mechanism. / 21.05.2019 / PubMed / Full text

CCL20

p53 and p53-related mediators PAI-1 and IGFBP-3 are downregulated in peripheral blood mononuclear cells of HIV-patients exposed to non-nucleoside reverse transcriptase inhibitors. / 06.2020 / PubMed / Full text
Effects of the Consumption of Milk Biofortified with Selenium, Vitamin E, and Different Fatty Acid Profile on Immune Response in the Elderly. / 02.2018 / PubMed / Full text

CCL21

CCL21/CCR7 axis regulating juvenile cartilage repair can enhance cartilage healing in adults. / 26.03.2019 / PubMed / Full text
Changes in expression of klotho affect physiological processes, diseases, and cancer. / 01.2018 / PubMed / Full text

CCL24

Regulatory T-cells regulate neonatal heart regeneration by potentiating cardiomyocyte proliferation in a paracrine manner. / 2019 / PubMed / Full text
Anserine/Carnosine Supplementation Suppresses the Expression of the Inflammatory Chemokine CCL24 in Peripheral Blood Mononuclear Cells from Elderly People. / 31.10.2017 / PubMed / Full text

CCN3

CCN3 Signaling Is Differently Regulated in Placental Diseases Preeclampsia and Abnormally Invasive Placenta. / 2020 / PubMed / Full text
CCN3 (NOV) Drives Degradative Changes in Aging Articular Cartilage. / 13.10.2020 / PubMed / Full text

CCNG2

A Novel [i]Dnmt3a1[/i] Transcript Inhibits Adipogenesis. / 2018 / PubMed / Full text
Hypoxia-inducible transcription factors, HIF1A and HIF2A, increase in aging mucosal tissues. / 07.2018 / PubMed / Full text

CCR6

Age-associated antigen-presenting cell alterations promote dry-eye inducing Th1 cells. / 07.2019 / PubMed / Full text
Age-related but not longevity-related genes are found by weighted gene co-expression network analysis in the peripheral blood cells of humans. / 19.01.2019 / PubMed / Full text

CD22

CD22 blockade restores homeostatic microglial phagocytosis in ageing brains. / 04.2019 / PubMed / Full text
Age-related changes in mRNA expression of selected surface receptors in lymphocytes of dairy calves. / 03.2018 / PubMed / Full text

CDK1

MicroRNAomic Transcriptomic Analysis Reveal Deregulation of Clustered Cellular Functions in Human Mesenchymal Stem Cells During in Vitro Passaging. / 02.2020 / PubMed / Full text
Targeting DTL induces cell cycle arrest and senescence and suppresses cell growth and colony formation through TPX2 inhibition in human hepatocellular carcinoma cells. / 2018 / PubMed / Full text

CDKN2B

Molecular Genetics and Functional Analysis Implicate [i]CDKN2BAS1-CDKN2B[/i] Involvement in POAG Pathogenesis. / 21.08.2020 / PubMed / Full text
Interference of the long noncoding RNA CDKN2B-AS1 upregulates miR-181a-5p/TGFβI axis to restrain the metastasis and promote apoptosis and senescence of cervical cancer cells. / 04.2019 / PubMed / Full text

CFD

Senescent dermal fibroblasts negatively influence fibroblast extracellular matrix-related gene expression partly via secretion of complement factor D. / 07.2019 / PubMed / Full text
New horizons in the compression of functional decline. / 01.11.2018 / PubMed / Full text

CHI3L1

Postsynaptic damage and microglial activation in AD patients could be linked CXCR4/CXCL12 expression levels. / 15.12.2020 / PubMed / Full text
Sex difference in CHI3L1 expression levels in human brain aging and in Alzheimer's disease. / 01.10.2019 / PubMed / Full text

CHM

[Molecular regulative mechanisms of aging and interventional effects of Chinese herbal medicine]. / 08.2017 / PubMed / Full text
[Molecular mechanisms of autophagy in regulating renal aging and interventional effects of Chinese herbal medicine]. / 11.2016 / PubMed / Full text

CISD2

CISD2 Attenuates Inflammation and Regulates Microglia Polarization in EOC Microglial Cells-As a Potential Therapeutic Target for Neurodegenerative Dementia. / 2020 / PubMed / Full text
Protective Effects of CISD2 and Influence of Curcumin on CISD2 Expression in Aged Animals and Inflammatory Cell Model. / 25.03.2019 / PubMed / Full text

CLC

Impact of Intervention to Improve Nursing Home Resident-Staff Interactions and Engagement. / 13.07.2018 / PubMed / Full text
Effect of cholesterol loaded cyclodextrin on semen cryopreservation of Aksaray Malakli shepherd dogs of different ages. / 06.2018 / PubMed / Full text

CLPP

Mitochondrial unfolded protein response: a stress response with implications for fertility and reproductive aging. / 02.2019 / PubMed / Full text
Mitochondrial unfolded protein response gene Clpp is required to maintain ovarian follicular reserve during aging, for oocyte competence, and development of pre-implantation embryos. / 08.2018 / PubMed / Full text

COL3A1

Different expression of Defensin-B gene in the endometrium of mares of different age during the breeding season. / 21.12.2019 / PubMed / Full text
Reductive Stress Selectively Disrupts Collagen Homeostasis and Modifies Growth Factor-independent Signaling Through the MAPK/Akt Pathway in Human Dermal Fibroblasts. / 06.2019 / PubMed / Full text

COPE

Patterns and characteristics of cognitive functioning in older patients approaching end stage kidney disease, the COPE-study. / 09.04.2020 / PubMed / Full text
Falls self-efficacy and falls incidence in community-dwelling older people: the mediating role of coping. / 05.2018 / PubMed / Full text

CPD

Reduced proliferation capacity of lung cells in chronic obstructive pulmonary disease. / 05.2019 / PubMed / Full text
What Do Clinical Supervisors Require to Teach Residents in Family Medicine How to Care for Seniors? / 03.2018 / PubMed / Full text

CPE

Cross-Sectional and Cumulative Longitudinal Central Nervous System Penetration Effectiveness Scores Are Not Associated With Neurocognitive Impairment in a Well Treated Aging Human Immunodeficiency Virus-Positive Population in Switzerland. / 07.2019 / PubMed / Full text
COCOA (Theobroma cacao) Polyphenol-Rich Extract Increases the Chronological Lifespan of Saccharomyces cerevisiae. / 2016 / PubMed

CPQ

A Spanish Adaptation of the Computer and Mobile Device Proficiency Questionnaires (CPQ and MDPQ) for Older Adults. / 2019 / PubMed / Full text
Protective Effect of Semisynthetic and Natural Flavonoid on Aged Rat Microglia-enriched Cultures. / 11.2019 / PubMed / Full text

CRABP2

Preconception resveratrol intake against infertility: Friend or foe? / 04.2020 / PubMed / Full text
Cross platform analysis of transcriptomic data identifies ageing has distinct and opposite effects on tendon in males and females. / 31.10.2017 / PubMed / Full text

CSRP1

FOXO3, a Molecular Search for the Fountain of Youth. / 07.03.2019 / PubMed / Full text
FOXO3-Engineered Human ESC-Derived Vascular Cells Promote Vascular Protection and Regeneration. / 07.03.2019 / PubMed / Full text

CTLA4

Horticultural Therapy Reduces Biomarkers of Immunosenescence and Inflammaging in Community-Dwelling Older Adults: A Feasibility Pilot Randomized Controlled Trial. / 18.10.2020 / PubMed / Full text
[Efficacy and toxicity of immune checkpoint inhibitors in elderly patients - 5th edition of the congress of pharmacology of anticancer drugs]. / 12.2018 / PubMed / Full text

CXCL11

Endothelial cells under therapy-induced senescence secrete CXCL11, which increases aggressiveness of breast cancer cells. / 10.10.2020 / PubMed / Full text
Prebiotic supplementation in frail older people affects specific gut microbiota taxa but not global diversity. / 13.03.2019 / PubMed / Full text

CXCL5

Hassall's corpuscles with cellular-senescence features maintain IFNα production through neutrophils and pDC activation in the thymus. / 05.03.2019 / PubMed / Full text
Urine Cytokine and Chemokine Levels Predict Urinary Tract Infection Severity Independent of Uropathogen, Urine Bacterial Burden, Host Genetics, and Host Age. / 09.2018 / PubMed / Full text

CYLD

Premature aging and cancer development in transgenic mice lacking functional CYLD. / 10.01.2019 / PubMed / Full text
Pathophysiological significance of cylindromatosis in the vascular endothelium and macrophages for the initiation of age-related atherogenesis. / 22.01.2019 / PubMed / Full text

CYP1A1

Genome-wide scan identified genetic variants associated with skin aging in a Chinese female population. / 10.2019 / PubMed / Full text
Furanoflavones pongapin and lanceolatin B blocks the cell cycle and induce senescence in CYP1A1-overexpressing breast cancer cells. / 15.12.2018 / PubMed / Full text

CYP1A2

Impact of Ethnicity-Specific Hepatic Microsomal Scaling Factor, Liver Weight, and Cytochrome P450 (CYP) 1A2 Content on Physiologically Based Prediction of CYP1A2-Mediated Pharmacokinetics in Young and Elderly Chinese Adults. / 07.2019 / PubMed / Full text
Pediatric Cytochrome P450 Activity Alterations in Nonalcoholic Steatohepatitis. / 12.2017 / PubMed / Full text

CYP27B1

Decreased Serum 25-Hydroxyvitamin D in Aging Male Mice Is Associated With Reduced Hepatic Cyp2r1 Abundance. / 01.08.2018 / PubMed / Full text
Oleanolic Acid Exerts Osteoprotective Effects and Modulates Vitamin D Metabolism. / 22.02.2018 / PubMed / Full text

CYP2D6

Application of a physiologically based pharmacokinetic model for the prediction of mirabegron plasma concentrations in a population with severe renal impairment. / 05.2019 / PubMed / Full text
[Use of Pharmacogenetic Information for Therapeutic Drug Monitoring of an Antiarrhythmic Drug]. / 2018 / PubMed / Full text

CYP3A4

Application of a physiologically based pharmacokinetic model for the prediction of mirabegron plasma concentrations in a population with severe renal impairment. / 05.2019 / PubMed / Full text
Effect of Age and Allele Variants of CYP3A5, CYP3A4, and POR Genes on the Pharmacokinetics of Cyclosporin A in Pediatric Renal Transplant Recipients From Serbia. / 12.2017 / PubMed / Full text

CYP7A1

Age-associated changes of cytochrome P450 and related phase-2 gene/proteins in livers of rats. / 2019 / PubMed / Full text
Combined toxicity of endosulfan and phenanthrene mixtures and induced molecular changes in adult Zebrafish (Danio rerio). / 03.2018 / PubMed / Full text

DAO

Age- and gender-dependent D-amino acid oxidase activity in mouse brain and peripheral tissues: implication for aging and neurodegeneration. / 01.08.2019 / PubMed / Full text
Blood levels of D-amino acid oxidase vs. D-amino acids in reflecting cognitive aging. / 01.11.2017 / PubMed / Full text

DAPK1

SerThr-PhosphoProteome of Brain from Aged PINK1-KO+A53T-SNCA Mice Reveals pT1928-MAP1B and pS3781-ANK2 Deficits, as Hub between Autophagy and Synapse Changes. / 04.07.2019 / PubMed / Full text
Degradation of Caytaxin Causes Learning and Memory Deficits via Activation of DAPK1 in Aging. / 05.2019 / PubMed / Full text

DDB1

DCAF1 regulates Treg senescence via the ROS axis during immunological aging. / 02.11.2020 / PubMed / Full text
Deletion of DDB1- and CUL4- associated factor-17 (Dcaf17) gene causes spermatogenesis defects and male infertility in mice. / 15.06.2018 / PubMed / Full text

DDX41

Salidroside influences the cellular cross-talk of human fetal lung diploid fibroblasts: A proteomic approach. / 03.2018 / PubMed / Full text
Sequential acquisition of mutations in myelodysplastic syndromes. / 2017 / PubMed / Full text

DDX58

Transcriptome analysis reveals immune-related gene expression changes with age in giant panda ([i]Ailuropoda melanoleuca[/i]) blood. / 14.01.2019 / PubMed / Full text
Age-associated mRNA expression changes in bovine endometrial cells in vitro. / 14.08.2017 / PubMed / Full text

DEGS1

[Frailty: Prevalence in the Resident Population of Germany 70 - 79 Years of Age - a Population-Based Approach]. / 11.2017 / PubMed / Full text
Physical exercise and cognitive function across the life span: Results of a nationwide population-based study. / 05.2018 / PubMed / Full text

DICER1

DICER1: A Key Player in Rheumatoid Arthritis, at the Crossroads of Cellular Stress, Innate Immunity, and Chronic Inflammation in Aging. / 2018 / PubMed / Full text
Profiling of m6A RNA modifications identified an age-associated regulation of AGO2 mRNA stability. / 06.2018 / PubMed / Full text

DISC1

Age-Related Changes in Topological Degradation of White Matter Networks and Gene Expression in Chronic Schizophrenia. / 11.2017 / PubMed / Full text
Disruption to schizophrenia-associated gene Fez1 in the hippocampus of HDAC11 knockout mice. / 19.09.2017 / PubMed / Full text

DKC1

Successful liver transplantation in short telomere syndromes without bone marrow failure due to DKC1 mutation. / 05.2020 / PubMed / Full text
Acute telomerase components depletion triggers oxidative stress as an early event previous to telomeric shortening. / 04.2018 / PubMed / Full text

DLX5

Inhibition of microRNA-27b-3p relieves osteoarthritis pain via regulation of KDM4B-dependent DLX5. / 09.2020 / PubMed / Full text
Detection and evaluation of DNA methylation markers found at SCGN and KLF14 loci to estimate human age. / 11.2017 / PubMed / Full text

DRD3

Image-guided phenotyping of ovariectomized mice: altered functional connectivity, cognition, myelination, and dopaminergic functionality. / 02.2019 / PubMed / Full text
Dopamine-Related Genotypes and Physical Activity Change During an Intervention: The Lifestyle Interventions and Independence for Elders Study. / 07.2018 / PubMed / Full text

DSP

Noradrenergic dysfunction accelerates LPS-elicited inflammation-related ascending sequential neurodegeneration and deficits in non-motor/motor functions. / 10.2019 / PubMed / Full text
Trade-offs in aging lung diseases: a review on shared but opposite genetic risk variants in idiopathic pulmonary fibrosis, lung cancer and chronic obstructive pulmonary disease. / 05.2018 / PubMed / Full text

DST

Ancestral germen/soma distinction in microbes: Expanding the disposable soma theory of aging to all unicellular lineages. / 07.2020 / PubMed / Full text
Diet Quality Is Associated With Mortality in Adults Aged 80 Years and Older: A Prospective Study. / 10.2019 / PubMed / Full text

E2F2

MicroRNA-31a-5p from aging BMSCs links bone formation and resorption in the aged bone marrow microenvironment. / 08.2018 / PubMed / Full text
In situ regeneration of retinal pigment epithelium by gene transfer of E2F2: a potential strategy for treatment of macular degenerations. / 12.2017 / PubMed / Full text

EDARADD

Age prediction in living: Forensic epigenetic age estimation based on blood samples. / 11.2020 / PubMed / Full text
DNA methylation levels in candidate genes associated with chronological age in mammals are not conserved in a long-lived seabird. / 2017 / PubMed / Full text

EN1

Electrochemically detecting DNA methylation in the EN1 gene promoter: implications for understanding ageing and disease. / 27.11.2020 / PubMed / Full text
The role of DNA methylation in ageing and cancer. / 11.2018 / PubMed / Full text

ERBB2

The biological age linked to oxidative stress modifies breast cancer aggressiveness. / 20.05.2018 / PubMed / Full text
Identification of human age-associated gene co-expressions in functional modules using liquid association. / 02.01.2018 / PubMed / Full text

ETS1

The transcription factor ETS1 promotes apoptosis resistance of senescent cholangiocytes by epigenetically up-regulating the apoptosis suppressor BCL2L1. / 06.12.2019 / PubMed / Full text
G protein-coupled receptor kinase 4-induced cellular senescence and its senescence-associated gene expression profiling. / 15.11.2017 / PubMed / Full text

F7

The Pattern of Mu Rhythm Modulation During Emotional Destination Memory: Comparison Between Mild Cognitive Impairment Patients and Healthy Controls. / 2019 / PubMed / Full text
High levels of incidental physical activity are positively associated with cognition and EEG activity in aging. / 2018 / PubMed / Full text

FAAH

Endocannabinoid genetic variation enhances vulnerability to THC reward in adolescent female mice. / 02.2020 / PubMed / Full text
Pharmacological convergence reveals a lipid pathway that regulates C. elegans lifespan. / 05.2019 / PubMed / Full text

FABP4

Senescence Alters PPARγ (Peroxisome Proliferator-Activated Receptor Gamma)-Dependent Fatty Acid Handling in Human Adipose Tissue Microvascular Endothelial Cells and Favors Inflammation. / 05.2018 / PubMed / Full text
Endothelial APLNR regulates tissue fatty acid uptake and is essential for apelin's glucose-lowering effects. / 13.09.2017 / PubMed / Full text

FANCD2

TFG-maintaining stability of overlooked FANCD2 confers early DNA-damage response. / 24.10.2020 / PubMed / Full text
FANCD2 and DNA Damage. / 19.08.2017 / PubMed / Full text

FGFR4

FGFR4 Inhibitor BLU9931 Attenuates Pancreatic Cancer Cell Proliferation and Invasion While Inducing Senescence: Evidence for Senolytic Therapy Potential in Pancreatic Cancer. / 14.10.2020 / PubMed / Full text
The Klotho proteins in health and disease. / 01.2019 / PubMed / Full text

FHL2

Genetic associations with age of menopause in familial longevity. / 10.2019 / PubMed / Full text
DNA methylation of the ELOVL2, FHL2, KLF14, C1orf132/MIR29B2C, and TRIM59 genes for age prediction from blood, saliva, and buccal swab samples. / 01.2019 / PubMed / Full text

FLT1

Novel molecular mechanisms for the adaptogenic effects of herbal extracts on isolated brain cells using systems biology. / 15.11.2018 / PubMed / Full text
Analysis of Polymorphisms in 59 Potential Candidate Genes for Association With Human Longevity. / 08.10.2018 / PubMed / Full text

FN1

Systems biology and network pharmacology of frailty reveal novel epigenetic targets and mechanisms. / 22.07.2019 / PubMed / Full text
Effects of Fibronectin 1 on Cell Proliferation, Senescence and Apoptosis of Human Glioma Cells Through the PI3K/AKT Signaling Pathway. / 2018 / PubMed / Full text

FOXA1

Analyses of an epigenetic switch involved in the activation of pioneer factor FOXA1 leading to the prognostic value of estrogen receptor and FOXA1 co-expression in breast cancer. / 28.09.2019 / PubMed / Full text
The correlation of copy number variations with longevity in a genome-wide association study of Han Chinese. / 05.06.2018 / PubMed / Full text

FOXF1

Functional CRISPR screen identifies AP1-associated enhancer regulating FOXF1 to modulate oncogene-induced senescence. / 17.08.2018 / PubMed / Full text
Co-culturing nucleus pulposus mesenchymal stem cells with notochordal cell-rich nucleus pulposus explants attenuates tumor necrosis factor-α-induced senescence. / 26.06.2018 / PubMed / Full text

FOXP3

Regulatory T-cells regulate neonatal heart regeneration by potentiating cardiomyocyte proliferation in a paracrine manner. / 2019 / PubMed / Full text
Enhanced expression of PD-1 and other activation markers by CD4+ T cells of young but not old patients with metastatic melanoma. / 06.2018 / PubMed / Full text

FSTL3

Activin type II receptor signaling in cardiac aging and heart failure. / 06.03.2019 / PubMed / Full text
Physiology of Activins/Follistatins: Associations With Metabolic and Anthropometric Variables and Response to Exercise. / 01.10.2018 / PubMed / Full text

FUNDC1

Mitochondria organize the cellular proteostatic response and promote cellular senescence. / 15.03.2019 / PubMed / Full text
A mitochondrial FUNDC1/HSC70 interaction organizes the proteostatic stress response at the risk of cell morbidity. / 01.02.2019 / PubMed / Full text

GALT

Microanatomical dissection of human intestinal T-cell immunity reveals site-specific changes in gut-associated lymphoid tissues over life. / 03.2019 / PubMed / Full text
Dietary Animal Plasma Proteins Improve the Intestinal Immune Response in Senescent Mice. / 11.12.2017 / PubMed / Full text

GAS6

Regulatory T-cells regulate neonatal heart regeneration by potentiating cardiomyocyte proliferation in a paracrine manner. / 2019 / PubMed / Full text
Red blood cell distribution width: Genetic evidence for aging pathways in 116,666 volunteers. / 2017 / PubMed / Full text

GATA2

GATA2 hypomorphism induces chronic myelomonocytic leukemia in mice. / 04.2019 / PubMed / Full text
Sequential acquisition of mutations in myelodysplastic syndromes. / 2017 / PubMed / Full text

GATA3

An imbalance in the T-helper phenotypes displayed by senescent CD4 CD28 T cells is associated with erosive arthritis (rhupus syndrome) in systemic lupus erythematosus. / 11.2018 / PubMed / Full text
Expression of Luminal Progenitor Marker CD117 in the Human Breast Gland. / 12.2018 / PubMed / Full text

GDF3

In vivo GDF3 administration abrogates aging related muscle regeneration delay following acute sterile injury. / 10.2018 / PubMed / Full text
Inflammasome-driven catecholamine catabolism in macrophages blunts lipolysis during ageing. / 05.10.2017 / PubMed / Full text

GIT2

Multidimensional informatic deconvolution defines gender-specific roles of hypothalamic GIT2 in aging trajectories. / 12.2019 / PubMed / Full text
GIT2-A keystone in ageing and age-related disease. / 05.2018 / PubMed / Full text

GK

Progression of diabetic kidney disease in T2DN rats. / 01.12.2019 / PubMed / Full text
Reactive oxygen species-induced changes in glucose and lipid metabolism contribute to the accumulation of cholesterol in the liver during aging. / 04.2019 / PubMed / Full text

GLS

Normal Values and Growth-Related Changes of Left Ventricular Volumes, Stress, and Strain in Healthy Children Measured by 3-Dimensional Echocardiography. / 15.07.2018 / PubMed / Full text
Future Perspectives for Management of Stage A Heart Failure. / 01.07.2018 / PubMed / Full text

GNG3

Gene Expression Analysis Reveals Novel Gene Signatures Between Young and Old Adults in Human Prefrontal Cortex. / 2018 / PubMed / Full text
Low expression of aging-related [[NRXN3]] is associated with Alzheimer disease: A systematic review and meta-analysis. / 07.2018 / PubMed / Full text

GNRH1

Novel molecular mechanisms for the adaptogenic effects of herbal extracts on isolated brain cells using systems biology. / 15.11.2018 / PubMed / Full text
Elucidating the genetic architecture of reproductive ageing in the Japanese population. / 17.05.2018 / PubMed / Full text

GPR39

Zinc-mediated Neurotransmission in Alzheimer's Disease: A Potential Role of the GPR39 in Dementia. / 2020 / PubMed / Full text
GPR39 agonist TC-G 1008 ameliorates IL-1β-induced chondrocyte senescence. / 12.2019 / PubMed / Full text

GPT

Brain Structural-Behavioral Correlates Underlying Grooved Pegboard Test Performance Across Lifespan. / 07.07.2020 / PubMed / Full text
Effects of tDCS of Dorsolateral Prefrontal Cortex on Dual-Task Performance Involving Manual Dexterity and Cognitive Task in Healthy Older Adults. / 2019 / PubMed / Full text

GRIK2

Senescence of Normal Human Fibroblasts Relates to the Expression of Ionotropic Glutamate Receptor GluR6/Grik2. / 11-12.2020 / PubMed / Full text
Isoforms of Ionotropic Glutamate Receptor GRIK2 Induce Senescence of Carcinoma Cells. / 01-02.2019 / PubMed / Full text

GRK5

Downregulation of thromboxane A2 and angiotensin II type 1 receptors associated with aging-related decrease in internal anal sphincter tone. / 01.05.2019 / PubMed / Full text
GRK5 - A Functional Bridge Between Cardiovascular and Neurodegenerative Disorders. / 2018 / PubMed / Full text

GRSF1

GRSF1 is an age-related regulator of senescence. / 03.04.2019 / PubMed / Full text
GRSF1 suppresses cell senescence. / 07.08.2018 / PubMed / Full text

GSTA4

Impaired enzymatic reactive aldehyde-detoxifying capacity and glutathione peroxidase activity in the aged human arterial tissue. / 02.2019 / PubMed / Full text
Age-associated changes in GSH S-transferase gene/proteins in livers of rats. / 12.2018 / PubMed / Full text

HAL

Comparison of haloperidol, non-haloperidol antipsychotics, and no pharmacotherapy for the management of delirium in an inpatient geriatric palliative care population. / 06-09.2018 / PubMed / Full text
Acute and long-term effects of haloperidol on surgery-induced neuroinflammation and cognitive deficits in aged rats. / 06.2019 / PubMed / Full text

HAPLN1

Remodeling of the Collagen Matrix in Aging Skin Promotes Melanoma Metastasis and Affects Immune Cell Motility. / 01.2019 / PubMed / Full text
Age-Related Changes in HAPLN1 Increase Lymphatic Permeability and Affect Routes of Melanoma Metastasis. / 01.2019 / PubMed / Full text

HAS1

A large-scale CRISPR screen and identification of essential genes in cellular senescence bypass. / 20.06.2019 / PubMed / Full text
Age-related changes in cyclic phosphatidic acid-induced hyaluronic acid synthesis in human fibroblasts. / 01.2018 / PubMed / Full text

HBP1

Suppression of p38/HBP1 pathway alleviates hyperosmotic stress-induced senescent progression of chondrocyte senescence. / 03-04.2020 / PubMed / Full text
Transcription factor HBP1: A regulator of senescence and apoptosis of preadipocytes. / 17.09.2019 / PubMed / Full text

HCN1

Protein expression changes of HCN1 and HCN2 in hippocampal subregions of gerbils during the normal aging process. / 11.2019 / PubMed / Full text
HCN as a Mediator of Urinary Homeostasis: Age-Associated Changes in Expression and Function in Adrenergic Detrusor Relaxation. / 15.02.2019 / PubMed / Full text

HGD

High-glucose diets induce mitochondrial dysfunction in Caenorhabditis elegans. / 2019 / PubMed / Full text
A high glucose diet induces autophagy in a HLH-30/TFEB-dependent manner and impairs the normal lifespan of [i]C. elegans[/i]. / 05.10.2018 / PubMed / Full text

HLA-A

Reduced expression of the lncRNA NRON is a potential hallmark of the CMV-amplified CD8+ T cell accumulations commonly seen in older humans. / 01.2019 / PubMed / Full text
Cytomegalovirus-Specific T Cells Restricted by HLA-Cw*0702 Increase Markedly with Age and Dominate the CD8 T-Cell Repertoire in Older People. / 2017 / PubMed / Full text

HLA-B

Epigenome-wide exploratory study of monozygotic twins suggests differentially methylated regions to associate with hand grip strength. / 10.2019 / PubMed / Full text
Cytomegalovirus-Specific T Cells Restricted by HLA-Cw*0702 Increase Markedly with Age and Dominate the CD8 T-Cell Repertoire in Older People. / 2017 / PubMed / Full text

HLA-C

Epigenome-wide exploratory study of monozygotic twins suggests differentially methylated regions to associate with hand grip strength. / 10.2019 / PubMed / Full text
Cytomegalovirus-Specific T Cells Restricted by HLA-Cw*0702 Increase Markedly with Age and Dominate the CD8 T-Cell Repertoire in Older People. / 2017 / PubMed / Full text

HLA-DPB1

17th IHIW component "Immunogenetics of Ageing" - New NGS data. / 09.2019 / PubMed / Full text
Epigenome-wide exploratory study of monozygotic twins suggests differentially methylated regions to associate with hand grip strength. / 10.2019 / PubMed / Full text

HMOX1

Well-aging: A new strategy for skin homeostasis under multi-stressed conditions. / 02.2020 / PubMed / Full text
Age-related distribution and potential role of SNCB in topographically different retinal areas of the common marmoset Callithrix jacchus, including the macula. / 08.2019 / PubMed / Full text

HRAS

How do combinations of unhealthy behaviors relate to attitudinal factors and subjective health among the adult population in the Netherlands? / 03.04.2020 / PubMed / Full text
Elucidating Proteoform Dynamics Underlying the Senescence Associated Secretory Phenotype. / 07.02.2020 / PubMed / Full text

HSF2

Identification of key genes and transcription factors in aging mesenchymal stem cells by DNA microarray data. / 15.04.2019 / PubMed / Full text
Nutrition and water temperature regulate the expression of heat-shock proteins in golden pompano larvae (Trachinotus ovata, Limmaeus 1758). / 04.2019 / PubMed / Full text

HSPA1A

Vitamin D3 treatment regulates apoptosis, antioxidant defense system, and DNA integrity in the epididymal sperm of an aged rat model. / 12.2019 / PubMed / Full text
The effect of aging on the autophagic and heat shock response in human peripheral blood mononuclear cells. / 01.09.2018 / PubMed / Full text

ID1

Commentary on Some Recent Theses Relevant to Combating Aging: April 2019. / 04.2019 / PubMed / Full text
ER stress and distinct outputs of the IRE1α RNase control proliferation and senescence in response to oncogenic Ras. / 12.09.2017 / PubMed / Full text

ID3

Transcription factor networks in aged naïve CD4 T cells bias lineage differentiation. / 08.2019 / PubMed / Full text
Proteomics and metabolomics identify molecular mechanisms of aging potentially predisposing for chronic lymphocytic leukemia. / 02.2018 / PubMed / Full text

IDE

Dendrobium nobile Lindl. Alkaloids Ameliorate Cognitive Dysfunction in Senescence Accelerated SAMP8 Mice by Decreasing Amyloid-β Aggregation and Enhancing Autophagy Activity. / 2020 / PubMed / Full text
Hyperinsulinemia is associated with increasing insulin secretion but not with decreasing insulin clearance in an age-related metabolic dysfunction mice model. / 06.2019 / PubMed / Full text

IDS

Effect of immediate dentine sealing on the aging and fracture strength of lithium disilicate inlays and overlays. / 10.2020 / PubMed / Full text
Increased double limb support times during walking in right limb dominant healthy older adults with low bone density. / 06.2018 / PubMed / Full text

IGFBP1

Role of IGFBP1 in the senescence of vascular endothelial cells and severity of aging‑related coronary atherosclerosis. / 11.2019 / PubMed / Full text
Dehydroepiandrosterone enhances decidualization in women of advanced reproductive age. / 04.2018 / PubMed / Full text

IL1A

IL1B triggers inflammatory cytokine production in bovine oviduct epithelial cells and induces neutrophil accumulation via CCL2. / 25.10.2020 / PubMed / Full text
Age-associated mRNA expression changes in bovine endometrial cells in vitro. / 14.08.2017 / PubMed / Full text

IL7

SCAMP4 enhances the senescent cell secretome. / 01.07.2018 / PubMed / Full text
Thymic Atrophy: Experimental Studies and Therapeutic Interventions. / 01.2018 / PubMed / Full text

INSL3

Effect of Thyroxine Replacement on Leydig Cell and Sertoli Cell Function in Men with Hypothyroidism. / 05-06.2020 / PubMed / Full text
Age related and seasonal changes of plasma concentrations of insulin-like peptide 3 and testosterone from birth to early-puberty in Thoroughbred male horses. / 01.07.2019 / PubMed / Full text

IQGAP1

IQGAP1-dysfunction leads to induction of senescence in human vascular smooth muscle cells. / 09.2020 / PubMed / Full text
Hyaluronan-binding protein 1 (HABP1) overexpression triggers induction of senescence in fibroblasts cells. / 06.2020 / PubMed / Full text

IRF4

Transcription factor networks in aged naïve CD4 T cells bias lineage differentiation. / 08.2019 / PubMed / Full text
Age-related differences in interferon regulatory factor-4 and -5 signaling in ischemic brains of mice. / 11.2017 / PubMed / Full text

IRF7

Transcriptome analysis reveals immune-related gene expression changes with age in giant panda ([i]Ailuropoda melanoleuca[/i]) blood. / 14.01.2019 / PubMed / Full text
Sirtuin 1-Chromatin-Binding Dynamics Points to a Common Mechanism Regulating Inflammatory Targets in SIV Infection and in the Aging Brain. / 06.2018 / PubMed / Full text

KIT

Prediction of ovarian aging using ovarian expression of BMP15, GDF9, and C-KIT. / 04.2020 / PubMed / Full text
miR-19b-3p induces cell proliferation and reduces heterochromatin-mediated senescence through PLZF in goat male germline stem cells. / 06.2018 / PubMed / Full text

L1CAM

Glioma malignancy is linked to interdependent and inverse AMOG and L1 adhesion molecule expression. / 12.09.2019 / PubMed / Full text
Induction, regulation and roles of neural adhesion molecule L1CAM in cellular senescence. / 28.03.2018 / PubMed / Full text

LAMP2

A pH probe inhibits senescence in mesenchymal stem cells. / 07.12.2018 / PubMed / Full text
Skeletal muscle from aged American Quarter Horses shows impairments in mitochondrial biogenesis and expression of autophagy markers. / 02.2018 / PubMed / Full text

LAT2

Blood glucose, amino acid profiles and nutrient transporter gene expressions in the small intestine of low and normal birthweight piglets during the early suckling period. / 05.2019 / PubMed / Full text
Skeletal muscle: from birth to old age, routes to mechanical and metabolic failure. / 2017 / PubMed / Full text

LATS2

[Expression relationship of Hippo signaling molecules and ovarian germline stem cell markers in the ovarian aging process of women and mice]. / 25.06.2019 / PubMed
YAP1-LATS2 feedback loop dictates senescent or malignant cell fate to maintain tissue homeostasis. / 03.2019 / PubMed / Full text

LCT

Functional MRI of Letter Cancellation Task Performance in Older Adults. / 2019 / PubMed / Full text
Milk Intake at Midlife and Cognitive Decline over 20 Years. The Atherosclerosis Risk in Communities (ARIC) Study. / 17.10.2017 / PubMed / Full text

LDHA

Upregulation of lactate-inducible snail protein suppresses oncogene-mediated senescence through p16 inactivation. / 26.02.2018 / PubMed / Full text
Role of Sirtuin1-p53 regulatory axis in aging, cancer and cellular reprogramming. / 05.2018 / PubMed / Full text

LIF

Aminopeptidase N expression in the endometrium could affect endometrial receptivity. / 25.06.2019 / PubMed / Full text
Efficacy of leukemia inhibitory factor as a therapeutic for permanent large vessel stroke differs among aged male and female rats. / 15.03.2019 / PubMed / Full text

LONP1

Mitochondria organize the cellular proteostatic response and promote cellular senescence. / 15.03.2019 / PubMed / Full text
A mitochondrial FUNDC1/HSC70 interaction organizes the proteostatic stress response at the risk of cell morbidity. / 01.02.2019 / PubMed / Full text

LOXL2

Lysyl Oxidase-Like 2 Protects against Progressive and Aging Related Knee Joint Osteoarthritis in Mice. / 27.09.2019 / PubMed / Full text
Lysyl oxidase-like 2 depletion is protective in age-associated vascular stiffening. / 01.07.2019 / PubMed / Full text

LRP4

Multiple MuSK signaling pathways and the aging neuromuscular junction. / 13.07.2020 / PubMed / Full text
Sarcoglycan Alpha Mitigates Neuromuscular Junction Decline in Aged Mice by Stabilizing LRP4. / 10.10.2018 / PubMed / Full text

LRP5

LRP5 in age-related changes in vascular and alveolar morphogenesis in the lung. / 05.01.2019 / PubMed / Full text
Wnt1 is an Lrp5-independent bone-anabolic Wnt ligand. / 07.11.2018 / PubMed / Full text

LSR

Age-related changes in regiospecific expression of Lipolysis Stimulated Receptor (LSR) in mice brain. / 2019 / PubMed / Full text
Discriminating Alzheimer's disease progression using a new hippocampal marker from T1-weighted MRI: The local surface roughness. / 01.04.2019 / PubMed / Full text

LTB

Aging and Hyperglycemia Intensify Dyslipidemia-Induced Oxidative Stress and Inflammation in Rats: Assessment of Restorative Potentials of ALA and EPA + DHA. / 06.2019 / PubMed / Full text
Advanced age in mares affects endometrial secretion of arachidonic acid metabolites during equine subclinical endometritis. / 11.2017 / PubMed / Full text

MALT1

MALT-1 mediates IL-17 neural signaling to regulate C. elegans behavior, immunity and longevity. / 29.04.2020 / PubMed / Full text
MALT1-Deficient Mice Develop Atopic-Like Dermatitis Upon Aging. / 2019 / PubMed / Full text

MAP1LC3B

The effect of aging on the autophagic and heat shock response in human peripheral blood mononuclear cells. / 01.09.2018 / PubMed / Full text
Inhibition of glioma growth by flavokawain B is mediated through endoplasmic reticulum stress induced autophagy. / 2018 / PubMed / Full text

MAPK14

Micro-RNAS Regulate Metabolic Syndrome-induced Senescence in Porcine Adipose Tissue-derived Mesenchymal Stem Cells through the P16/MAPK Pathway. / 10.2018 / PubMed / Full text
G protein-coupled receptor kinase 4-induced cellular senescence and its senescence-associated gene expression profiling. / 15.11.2017 / PubMed / Full text

MAPK3

A tyrosine kinase-activating variant Asn666Ser in PDGFRB causes a progeria-like condition in the severe end of Penttinen syndrome. / 04.2019 / PubMed / Full text
Micro-RNAS Regulate Metabolic Syndrome-induced Senescence in Porcine Adipose Tissue-derived Mesenchymal Stem Cells through the P16/MAPK Pathway. / 10.2018 / PubMed / Full text

MAPKAPK2

Quantitative In Vivo Proteomics of Metformin Response in Liver Reveals AMPK-Dependent and -Independent Signaling Networks. / 03.12.2019 / PubMed / Full text
Cell fate regulation by reticulon-4 in human prostate cancers. / 07.2019 / PubMed / Full text

MARCO

Age-dependent effect between MARCO and TLR4 on PMMA particle phagocytosis by macrophages. / 08.2019 / PubMed / Full text
Aging-Impaired Filamentous Actin Polymerization Signaling Reduces Alveolar Macrophage Phagocytosis of Bacteria. / 01.11.2017 / PubMed / Full text

MCL1

MCL1 gene silencing promotes senescence and apoptosis of glioma cells via inhibition of the PI3K/Akt signaling pathway. / 01.2019 / PubMed / Full text
A lowered 26S proteasome activity correlates with mantle lymphoma cell lines resistance to genotoxic stress. / 10.08.2017 / PubMed / Full text

MCM2

Trophoblast type-specific expression of senescence markers in the human placenta. / 15.09.2019 / PubMed / Full text
Changes in MCM2-7 proteins at senescence. / 27.07.2019 / PubMed / Full text

MCM7

Changes in MCM2-7 proteins at senescence. / 27.07.2019 / PubMed / Full text
Inhibition of CIP2A attenuates tumor progression by inducing cell cycle arrest and promoting cellular senescence in hepatocellular carcinoma. / 08.01.2018 / PubMed / Full text

MDH1

Oxidative Damage to the TCA Cycle Enzyme MDH1 Dysregulates Bioenergetic Enzymatic Activity in the Aged Murine Brain. / 03.04.2020 / PubMed / Full text
Low-Dose Pesticide Mixture Induces Accelerated Mesenchymal Stem Cell Aging In Vitro. / 08.2019 / PubMed / Full text

MEIS1

Down-regulation of MEIS1 promotes the maturation of oxidative phosphorylation in perinatal cardiomyocytes. / 06.2019 / PubMed / Full text
Chronological age prediction based on DNA methylation: Massive parallel sequencing and random forest regression. / 11.2017 / PubMed / Full text

MIF

Mitochondrial DNA alterations in aged macrophage migration inhibitory factor-knockout mice. / 09.2019 / PubMed / Full text
Macrophage migration inhibitory factor knockdown inhibit viability and induce apoptosis of PVM/Ms. / 12.2017 / PubMed / Full text

MLH1

The somatic mutation landscape of the human body. / 24.12.2019 / PubMed / Full text
RNA-Seq analysis of differentially expressed genes relevant to mismatch repair in aging hematopoietic stem-progenitor cells. / 25.02.2019 / PubMed / Full text

MMP3

Systemic analysis of gene expression profiles in porcine granulosa cells during aging. / 14.11.2017 / PubMed / Full text
Identification of a pyridine derivative inducing senescence in ovarian cancer cell lines via P21 activation. / 05.2018 / PubMed / Full text

MTM1

Amphiphysin 2 modulation rescues myotubular myopathy and prevents focal adhesion defects in mice. / 20.03.2019 / PubMed / Full text
Tamoxifen prolongs survival and alleviates symptoms in mice with fatal X-linked myotubular myopathy. / 19.11.2018 / PubMed / Full text

MTMR14

EDTP/MTMR14: A novel target for improved survivorship to prolonged anoxia and cellular protein aggregates. / 13.07.2019 / PubMed / Full text
Downregulation of EDTP in glial cells suppresses polyglutamine protein aggregates and extends lifespan in Drosophila melanogaster. / 16.02.2019 / PubMed / Full text

MVD

Prostate cancer aggressiveness and age: Impact of p53, BCL-2 and microvessel density. / 12.2018 / PubMed / Full text
Assessing Microvascular Function in Humans from a Chronic Disease Perspective. / 12.2017 / PubMed / Full text

NAV2

Genetic associations with age of menopause in familial longevity. / 10.2019 / PubMed / Full text
Low expression of aging-related [[NRXN3]] is associated with Alzheimer disease: A systematic review and meta-analysis. / 07.2018 / PubMed / Full text

NCL

Factors Affecting Microvascular Responses in the Bulbar Conjunctiva in Habitual Contact Lens Wearers. / 01.08.2018 / PubMed / Full text
Small nucleoli are a cellular hallmark of longevity. / 30.08.2017 / PubMed / Full text

NDNF

Effect of neuron-derived neurotrophic factor on rejuvenation of human adipose-derived stem cells for cardiac repair after myocardial infarction. / 09.2019 / PubMed / Full text
Aged Human Multipotent Mesenchymal Stromal Cells Can Be Rejuvenated by Neuron-Derived Neurotrophic Factor and Improve Heart Function After Injury. / 12.2017 / PubMed / Full text

NDUFB8

Effect of Melatonin on Rat Heart Mitochondria in Acute Heart Failure in Aged Rats. / 23.05.2018 / PubMed / Full text
Maternal nutrient restriction in baboon programs later-life cellular growth and respiration of cultured skin fibroblasts: a potential model for the study of aging-programming interactions. / 06.2018 / PubMed / Full text

NECTIN2

Genetics of Human Longevity From Incomplete Data: New Findings From the Long Life Family Study. / 08.10.2018 / PubMed / Full text
Apolipoprotein E region molecular signatures of Alzheimer's disease. / 08.2018 / PubMed / Full text

NLRC4

Hyperglycemia-induced inflamm-aging accelerates gingival senescence via NLRC4 phosphorylation. / 06.12.2019 / PubMed / Full text
Contribution of the inflammasome to inflammaging. / 2018 / PubMed / Full text

NMNAT1

ADNP differentially interact with genes/proteins in correlation with aging: a novel marker for muscle aging. / 06.2019 / PubMed / Full text
Genome-wide association study and annotating candidate gene networks affecting age at first calving in Nellore cattle. / 12.2017 / PubMed / Full text

NMNAT2

NMNAT2-mediated NAD generation is essential for quality control of aged oocytes. / 06.2019 / PubMed / Full text
Sarm1 Deletion, but Not Wld , Confers Lifelong Rescue in a Mouse Model of Severe Axonopathy. / 03.10.2017 / PubMed / Full text

NNMT

Small molecule nicotinamide N-methyltransferase inhibitor activates senescent muscle stem cells and improves regenerative capacity of aged skeletal muscle. / 05.2019 / PubMed / Full text
Nicotinamide-N-methyltransferase controls behavior, neurodegeneration and lifespan by regulating neuronal autophagy. / 09.2018 / PubMed / Full text

NOP10

Pseudouridylation defect due to [i]DKC1[/i] and [i]NOP10[/i] mutations causes nephrotic syndrome with cataracts, hearing impairment, and enterocolitis. / 30.06.2020 / PubMed / Full text
Acute telomerase components depletion triggers oxidative stress as an early event previous to telomeric shortening. / 04.2018 / PubMed / Full text

NOS2

Genetic background, epigenetic factors and dietary interventions which influence human longevity. / 10.2019 / PubMed / Full text
Secreted α-Klotho maintains cartilage tissue homeostasis by repressing [i]NOS2[/i] and [i]ZIP8-MMP13[/i] catabolic axis. / 19.06.2018 / PubMed / Full text

NOTCH3

Whole-Exome Sequencing of an Exceptional Longevity Cohort. / 16.08.2019 / PubMed / Full text
Mendelian adult-onset leukodystrophy genes in Alzheimer's disease: critical influence of CSF1R and NOTCH3. / 06.2018 / PubMed / Full text

NPR1

The NPR1-WRKY46-WRKY6 signaling cascade mediates probenazole/salicylic acid-elicited leaf senescence in Arabidopsis thaliana. / 03.12.2020 / PubMed / Full text
Loss of proton/calcium exchange 1 results in the activation of plant defense and accelerated senescence in Arabidopsis. / 07.2020 / PubMed / Full text

NRK

[Molecular mechanisms of mycelium of Cordyceps sinensis ameliorating renal tubular epithelial cells aging induced by D-galactose via inhibiting autophagy-related AMPK/ULK1 signaling activation]. / 03.2019 / PubMed / Full text
Hyperoside attenuates renal aging and injury induced by D-galactose via inhibiting AMPK-ULK1 signaling-mediated autophagy. / 24.12.2018 / PubMed / Full text

NTS

Neuropeptide changes in the suprachiasmatic nucleus are associated with the development of hypertension. / 08.2019 / PubMed / Full text
Aging affects isoproterenol-induced water drinking, astrocyte density, and central neuronal activation in female Brown Norway rats. / 01.08.2018 / PubMed / Full text

OAT

Opioid agonist treatment reduces losses in quality of life and quality-adjusted life expectancy in heroin users: Evidence from real world data. / 01.08.2019 / PubMed / Full text
Strength training and aerobic exercise alter mitochondrial parameters in brown adipose tissue and equally reduce body adiposity in aged rats. / 02.2019 / PubMed / Full text

PAK1

1,2,3-Triazolyl ester of ketorolac (15K): Boosting both heat-endurance and lifespan of C. elegans by down-regulating PAK1 at nM levels. / 2018 / PubMed / Full text
From bench (laboratory) to bed (hospital/home): How to explore effective natural and synthetic PAK1-blockers/longevity-promoters for cancer therapy. / 15.12.2017 / PubMed / Full text

PAPPA

Proteomic profiling of follicle fluids after superstimulation in one-month-old lambs. / 02.2018 / PubMed / Full text
Genome-wide association study and annotating candidate gene networks affecting age at first calving in Nellore cattle. / 12.2017 / PubMed / Full text

PDC

The mitochondrial translocase of the inner membrane PaTim54 is involved in defense response and longevity in Podospora anserina. / 11.2019 / PubMed / Full text
Neuron-specific knockdown of Drosophila PDHB induces reduction of lifespan, deficient locomotive ability, abnormal morphology of motor neuron terminals and photoreceptor axon targeting. / 15.05.2018 / PubMed / Full text

PDCD4

Petal abscission in roses is associated with the activation of a truncated version of the animal PDCD4 homologue, RbPCD1. / 11.2019 / PubMed / Full text
PDCD4 Knockdown Induces Senescence in Hepatoma Cells by Up-Regulating the p21 Expression. / 2018 / PubMed / Full text

PDE4D

Phosphodiesterase PDE4D Is Decreased in Frontal Cortex of Aged Rats and Positively Correlated With Working Memory Performance and Inversely Correlated With PKA Phosphorylation of Tau. / 2020 / PubMed / Full text
Compound D159687, a phosphodiesterase 4D inhibitor, induces weight and fat mass loss in aged mice without changing lean mass, physical and cognitive function. / 02.12.2018 / PubMed / Full text

PER1

Quercetin, caffeic acid and resveratrol regulate circadian clock genes and aging-related genes in young and old human lung fibroblast cells. / 02.2020 / PubMed / Full text
Is the aging human ovary still ticking?: Expression of clock-genes in luteinized granulosa cells of young and older women. / 21.11.2018 / PubMed / Full text

PF4

TMT-Based Quantitative Proteomic Analysis Reveals Proteomic Changes Involved in Longevity. / 07.2019 / PubMed / Full text
Effects of collagen peptides intake on skin ageing and platelet release in chronologically aged mice revealed by cytokine array analysis. / 01.2018 / PubMed / Full text

PGD

Primary Care for the Elderly Bereaved: Recommendations for Medical Education. / 12.2018 / PubMed / Full text
High percentages of embryos with 21, 18 or 13 trisomy are related to advanced paternal age in donor egg cycles. / 01.03.2018 / PubMed / Full text

PGP

Age-associated changes of the intrinsic nervous system in relation with interstitial cells in the pre-weaning goat rumen. / 14.07.2019 / PubMed / Full text
Changes in the interstitial cells of Cajal and neuronal nitric oxide synthase positive neuronal cells with aging in the esophagus of F344 rats. / 2017 / PubMed / Full text

PIEZO1

Niche stiffness underlies the ageing of central nervous system progenitor cells. / 09.2019 / PubMed / Full text
On the Mechanism of Human Red Blood Cell Longevity: Roles of Calcium, the Sodium Pump, PIEZO1, and Gardos Channels. / 2017 / PubMed / Full text

PIK3CG

Myocyte enhancer factor 2A delays vascular endothelial cell senescence by activating the PI3K/p-Akt/SIRT1 pathway. / 10.06.2019 / PubMed / Full text
MEF2A alters the proliferation, inflammation-related gene expression profiles and its silencing induces cellular senescence in human coronary endothelial cells. / 18.03.2019 / PubMed / Full text

PLD2

Age-related distribution and potential role of SNCB in topographically different retinal areas of the common marmoset Callithrix jacchus, including the macula. / 08.2019 / PubMed / Full text
Role of phospholipase D in the lifespan of Caenorhabditis elegans. / 06.04.2018 / PubMed / Full text

PLIN2

Cardiac overexpression of perilipin 2 induces atrial steatosis, connexin 43 remodeling, and atrial fibrillation in aged mice. / 01.12.2019 / PubMed / Full text
HDAC6 Suppresses Age-Dependent Ectopic Fat Accumulation by Maintaining the Proteostasis of PLIN2 in Drosophila. / 09.10.2017 / PubMed / Full text

PLK4

A novel lncRNA PLK4 up-regulated by talazoparib represses hepatocellular carcinoma progression by promoting YAP-mediated cell senescence. / 05.2020 / PubMed / Full text
Differential expression of AURKA/PLK4 in quiescence and senescence of osteosarcoma U2OS cells. / 04.2020 / PubMed / Full text

POSTN

A Transcriptome Study of Progeroid Neurocutaneous Syndrome Reveals POSTN As a New Element in Proline Metabolic Disorder. / 12.2018 / PubMed / Full text
Proteomic profiling of follicle fluids after superstimulation in one-month-old lambs. / 02.2018 / PubMed / Full text

POT1

MiR-185 targets POT1 to induce telomere dysfunction and cellular senescence. / 18.07.2020 / PubMed / Full text
Seryl tRNA synthetase cooperates with POT1 to regulate telomere length and cellular senescence. / 2019 / PubMed / Full text

PPID

Relationships of inflamm-aging with circulating nutrient levels, body composition, age, and pituitary pars intermedia dysfunction in a senior horse population. / 03.2020 / PubMed / Full text
Epidemiology of pituitary pars intermedia dysfunction: A systematic literature review of clinical presentation, disease prevalence and risk factors. / 05.2018 / PubMed / Full text

PPM1D

Detectible mosaic truncating PPM1D mutations, age and breast cancer risk. / 06.2019 / PubMed / Full text
Age-related remodelling of oesophageal epithelia by mutated cancer drivers. / 01.2019 / PubMed / Full text

PRC1

Timosaponin A-III inhibits oncogenic phenotype via regulation of PcG protein BMI1 in breast cancer cells. / 07.2018 / PubMed / Full text
Epigenetic factors Polycomb (Pc) and Suppressor of zeste (Su(z)2) negatively regulate longevity in Drosophila melanogaster. / 02.2018 / PubMed / Full text

PROC

Does midlife aging impact women's sleep duration, continuity, and timing?: A longitudinal analysis from the Study of Women's Health Across the Nation. / 15.04.2020 / PubMed / Full text
Effects of feeding frequency of an elevated plane of milk replacer and calf age on behavior, and glucose and insulin kinetics in male Holstein calves. / 07.2019 / PubMed / Full text

PSEN2

Accelerated brain aging towards transcriptional inversion in a zebrafish model of the K115fs mutation of human PSEN2. / 2020 / PubMed / Full text
Loss of presenilin 2 age-dependently alters susceptibility to acute seizures and kindling acquisition. / 03.2020 / PubMed / Full text

PTBP1

Dual functions for OVAAL in initiation of RAF/MEK/ERK prosurvival signals and evasion of p27-mediated cellular senescence. / 11.12.2018 / PubMed / Full text
PTBP1-Mediated Alternative Splicing Regulates the Inflammatory Secretome and the Pro-tumorigenic Effects of Senescent Cells. / 09.07.2018 / PubMed / Full text

PTPN11

Fine mapping genetic variants associated with age at puberty and sow fertility using SowPro90 genotyping array. / 01.10.2020 / PubMed / Full text
A tyrosine kinase-activating variant Asn666Ser in PDGFRB causes a progeria-like condition in the severe end of Penttinen syndrome. / 04.2019 / PubMed / Full text

PTS

Posttraumatic stress symptom persistence across 24 years: association with brain structures. / 08.2020 / PubMed / Full text
Association of prenatal and childhood environment smoking exposure with puberty timing: a systematic review and meta-analysis. / 18.07.2018 / PubMed / Full text

PTX3

Aerobic Training Down-Regulates Pentraxin 3 and Pentraxin 3/Toll-Like Receptor 4 Ratio, Irrespective of Oxidative Stress Response, in Elderly Subjects. / 27.01.2020 / PubMed / Full text
Sex Differences in the Association Between Pentraxin 3 and Cognitive Decline: The Cardiovascular Health Study. / 13.07.2020 / PubMed / Full text

PUM2

PUMILIO hyperactivity drives premature aging of [i]Norad[/i]-deficient mice. / 08.02.2019 / PubMed / Full text
The RNA-Binding Protein PUM2 Impairs Mitochondrial Dynamics and Mitophagy During Aging. / 21.02.2019 / PubMed / Full text

PYY

Peptide YY (PYY) Is Expressed in Human Skeletal Muscle Tissue and Expanding Human Muscle Progenitor Cells. / 2019 / PubMed / Full text
Peptide YY induces characteristic meal patterns of aged mice. / 11.2017 / PubMed / Full text

RAD52

Quantitative assessment of changes in cell growth, size and morphology during telomere-initiated cellular senescence in Saccharomyces cerevisiae. / 01.08.2019 / PubMed / Full text
Increased age-adjusted hazard of death associated with a common single nucleotide polymorphism of the human RAD52 gene in a cardiovascular cohort. / 10.2017 / PubMed / Full text

RAG1

T cell senescence accelerates Angiotensin II-induced target organ damage. / 12.02.2020 / PubMed / Full text
Aged murine hematopoietic stem cells drive aging-associated immune remodeling. / 09.08.2018 / PubMed / Full text

RAN

Rapid automatized naming (RAN): effects of aging on a predictor of reading skill. / 17.08.2020 / PubMed / Full text
SCA8 RAN polySer protein preferentially accumulates in white matter regions and is regulated by eIF3F. / 01.10.2018 / PubMed / Full text

RGN

Effect of senescence marker protein 30 on the proliferation and apoptosis of human lens epithelial cells SRA01/04. / 2018 / PubMed / Full text
Effect of supplementation of recombinant Regucalcin in extender on cryopreservation of spermatozoa of water buffalo (Bubalus bubalis). / 11.2017 / PubMed / Full text

RIG

Protective Effect of Klotho against Ischemic Brain Injury Is Associated with Inhibition of RIG-I/NF-κB Signaling. / 2017 / PubMed / Full text
Aging impairs both primary and secondary RIG-I signaling for interferon induction in human monocytes. / 12.12.2017 / PubMed / Full text

RNF8

Expression of RNF8 on cochlear apoptosis and aging in mice of different ages. / 03-Apr,.2019 / PubMed
Function of RAD6B and RNF8 in spermatogenesis. / 2018 / PubMed / Full text

RPS6

Regulation of Amino Acid Transporters and Sensors in Response to a High protein Diet: A Randomized Controlled Trial in Elderly Men. / 2019 / PubMed / Full text
Endothelial replicative senescence delayed by the inhibition of MTORC1 signaling involves MicroRNA-107. / 08.2018 / PubMed / Full text

RTEL1

Telomere length and aging-related outcomes in humans: A Mendelian randomization study in 261,000 older participants. / 12.2019 / PubMed / Full text
Genome-wide association study of telomere length among South Asians identifies a second RTEL1 association signal. / 01.2018 / PubMed / Full text

RUNX1

RUNX-mediated growth arrest and senescence are attenuated by diverse mechanisms in cells expressing RUNX1 fusion oncoproteins. / 03.2018 / PubMed / Full text
Sequential acquisition of mutations in myelodysplastic syndromes. / 2017 / PubMed / Full text

S100A4

Protective role of mesenchymal stem cells and mesenchymal stem cell-derived exosomes in cigarette smoke-induced mitochondrial dysfunction in mice. / 15.12.2019 / PubMed / Full text
Tissue Taurine Depletion Induces Profibrotic Pattern of Gene Expression and Causes Aging-Related Cardiac Fibrosis in Heart in Mice. / 2018 / PubMed / Full text

S1PR1

Aging Suppresses Sphingosine-1-Phosphate Chaperone ApoM in Circulation Resulting in Maladaptive Organ Repair. / 22.06.2020 / PubMed / Full text
Profiling the lymphoid-resident T cell pool reveals modulation by age and microbiota. / 04.01.2018 / PubMed / Full text

SAA1

Naturally occurring antibodies against serum amyloid A reduce IL-6 release from peripheral blood mononuclear cells. / 2018 / PubMed / Full text
Association between local inflammation and breast tissue age-related lobular involution among premenopausal and postmenopausal breast cancer patients. / 2017 / PubMed / Full text

SCAP

Dementia outcomes after addition of proxy-based assessments for deceased or proxy-dependent participants. / 10.2019 / PubMed / Full text
Increased hepatic INSIG-SCAP-SREBP expression is associated with cholesterol metabolism disorder in assisted reproductive technology-conceived aged mice. / 03.2019 / PubMed / Full text

SESN2

Copy Number Alterations in Papillary Thyroid Carcinomas: Does Loss of [i]SESN2[/i] Have a Role in Age-related Different Prognoses? / 09-10.2020 / PubMed / Full text
Loss of sestrin 2 potentiates the early onset of age-related sensory cell degeneration in the cochlea. / 11.10.2017 / PubMed / Full text

SLC25A24

De Novo Mutations in SLC25A24 Cause a Disorder Characterized by Early Aging, Bone Dysplasia, Characteristic Face, and Early Demise. / 02.11.2017 / PubMed / Full text
De Novo Mutations in SLC25A24 Cause a Craniosynostosis Syndrome with Hypertrichosis, Progeroid Appearance, and Mitochondrial Dysfunction. / 02.11.2017 / PubMed / Full text

SMAD2

Prostate epithelial-specific expression of activated PI3K drives stromal collagen production and accumulation. / 02.2020 / PubMed / Full text
Restoring extracellular matrix synthesis in senescent stem cells. / 10.2019 / PubMed / Full text

SMAD4

A clinical trial of somatic and germline analyses for healthy longevity in a postoperative cancer patient. / 09.2019 / PubMed / Full text
E47 Governs the MYC-CDKN1B/p27 -RB Network to Growth Arrest PDA Cells Independent of CDKN2A/p16 and Wild-Type p53. / 2018 / PubMed / Full text

SNCB

Age-related distribution and potential role of SNCB in topographically different retinal areas of the common marmoset Callithrix jacchus, including the macula. / 08.2019 / PubMed / Full text
Age-related Beta-synuclein Alters the p53/Mdm2 Pathway and Induces the Apoptosis of Brain Microvascular Endothelial Cells In Vitro. / 05.2018 / PubMed / Full text

SOCS1

Individual and combined effects of salinity and lipopolysaccharides on the immune response of juvenile Takifugu fasciatus. / 06.2019 / PubMed / Full text
SOCS1 regulates senescence and ferroptosis by modulating the expression of p53 target genes. / 28.10.2017 / PubMed / Full text

SORL1

A candidate gene study of risk for dementia in older, postmenopausal women: Results from the Women's Health Initiative Memory Study. / 05.2019 / PubMed / Full text
Genetic Risk for Age-Related Cognitive Impairment Does Not Predict Cognitive Performance in Middle Age. / 2018 / PubMed / Full text

SOST

Low Serum Levels of DKK2 Predict Incident Low-Impact Fracture in Older Women. / 07.2019 / PubMed / Full text
Bone adaptation in response to treadmill exercise in young and adult mice. / 06.2018 / PubMed / Full text

SPARCL1

Specific factors in blood from young but not old mice directly promote synapse formation and NMDA-receptor recruitment. / 18.06.2019 / PubMed / Full text
SPARCL1 Accelerates Symptom Onset in Alzheimer's Disease and Influences Brain Structure and Function During Aging. / 2018 / PubMed / Full text

SPR

Regulation of lifespan by neural excitation and REST. / 10.2019 / PubMed / Full text
How many geriatricians should, at minimum, be staffing health regions in Australia? / 03.2018 / PubMed / Full text

SRR

Mediterranean diet and its components in relation to all-cause mortality: meta-analysis. / 11.2018 / PubMed / Full text
Genetic Biomarkers on Age-Related Cognitive Decline. / 2017 / PubMed / Full text

SSB

Modelling the Effects of Beverage Substitution during Adolescence on Later Obesity Outcomes in Early Adulthood: Results from the Raine Study. / 03.12.2019 / PubMed / Full text
WHIRLY1 Occupancy Affects Histone Lysine Modification and [i]WRKY53[/i] Transcription in [i]Arabidopsis[/i] Developmental Manner. / 2018 / PubMed / Full text

STAT5A

Novel molecular mechanisms for the adaptogenic effects of herbal extracts on isolated brain cells using systems biology. / 15.11.2018 / PubMed / Full text
SOCS1 regulates senescence and ferroptosis by modulating the expression of p53 target genes. / 28.10.2017 / PubMed / Full text

STIM1

Progerin in muscle leads to thermogenic and metabolic defects via impaired calcium homeostasis. / 02.2020 / PubMed / Full text
Ca entry via TRPC1 is essential for cellular differentiation and modulates secretion via the SNARE complex. / 01.07.2019 / PubMed / Full text

SUV39H1

Increase in hippocampal histone H3K9me3 is negatively correlated with memory in old male mice. / 04.2020 / PubMed / Full text
Triptolide Promotes Senescence of Prostate Cancer Cells Through Histone Methylation and Heterochromatin Formation / 27.09.2017 / PubMed / Full text

SV2A

Assessing Synaptic Density in Alzheimer Disease With Synaptic Vesicle Glycoprotein 2A Positron Emission Tomographic Imaging. / 01.10.2018 / PubMed / Full text
Mutant Huntingtin Causes a Selective Decrease in the Expression of Synaptic Vesicle Protein 2C. / 10.2018 / PubMed / Full text

TAS2R16

Taste receptor polymorphisms and longevity: a systematic review and meta-analysis. / 10.11.2020 / PubMed / Full text
Taste receptors, innate immunity and longevity: the case of TAS2R16 gene. / 2019 / PubMed / Full text

TAS2R38

TAS2R38 bitter taste receptor and attainment of exceptional longevity. / 02.12.2019 / PubMed / Full text
Bitter, Sweet, Salty, Sour and Umami Taste Perception Decreases with Age: Sex-Specific Analysis, Modulation by Genetic Variants and Taste-Preference Associations in 18 to 80 Year-Old Subjects. / 18.10.2018 / PubMed / Full text

TAT

Mitochondrial Quality Control in Aging and Heart Failure: Influence of Ketone Bodies and Mitofusin-Stabilizing Peptides. / 2019 / PubMed / Full text
Effects of HIV-1 gp120 and TAT-derived microvesicles on endothelial cell function. / 01.05.2019 / PubMed / Full text

TBC1D5

TBC1D5-Catalyzed Cycling of Rab7 Is Required for Retromer-Mediated Human Papillomavirus Trafficking during Virus Entry. / 09.06.2020 / PubMed / Full text
Retromer and TBC1D5 maintain late endosomal RAB7 domains to enable amino acid-induced mTORC1 signaling. / 02.09.2019 / PubMed / Full text

TBK1

Parkin overexpression alleviates cardiac aging through facilitating K63-polyubiquitination of TBK1 to facilitate mitophagy. / 01.01.2021 / PubMed / Full text
TBK1 Suppresses RIPK1-Driven Apoptosis and Inflammation during Development and in Aging. / 06.09.2018 / PubMed / Full text

TCF7L2

A myelin-related transcriptomic profile is shared by Pitt-Hopkins syndrome models and human autism spectrum disorder. / 03.2020 / PubMed / Full text
Lifelong physical activity is associated with promoter hypomethylation of genes involved in metabolism, myogenesis, contractile properties and oxidative stress resistance in aged human skeletal muscle. / 01.03.2019 / PubMed / Full text

TIMELESS

Loss of circadian protein TIMELESS accelerates the progression of cellular senescence. / 18.09.2018 / PubMed / Full text
Clock gene expression and locomotor activity predict death in the last days of life in Drosophila melanogaster. / 09.08.2018 / PubMed / Full text

TIMP1

Design, cyclization, and optimization of MMP13-TIMP1 interaction-derived self-inhibitory peptides against chondrocyte senescence in osteoarthritis. / 01.2019 / PubMed / Full text
Retinoic acid promotes in vitro follicle activation in the cat ovary by regulating expression of matrix metalloproteinase 9. / 2018 / PubMed / Full text

TLR7

Bovine Lactoferrin Enhances TLR7-Mediated Responses in Plasmacytoid Dendritic Cells in Elderly Women: Results From a Nutritional Intervention Study With Bovine Lactoferrin, GOS and Vitamin D. / 2018 / PubMed / Full text
B cell responses to apoptotic cells in MFG-E8-/- mice. / 2018 / PubMed / Full text

TMPRSS2

Susceptibility to COVID-19 in populations with health disparities: Posited involvement of mitochondrial disorder, socioeconomic stress, and pollutants. / 09.09.2020 / PubMed / Full text
Expression of the SARS-CoV-2 Entry Proteins, ACE2 and TMPRSS2, in Cells of the Olfactory Epithelium: Identification of Cell Types and Trends with Age. / 03.06.2020 / PubMed / Full text

TNNT3

Genome-wide associations and detection of potential candidate genes for direct genetic and maternal genetic effects influencing dairy cattle body weight at different ages. / 06.02.2019 / PubMed / Full text
Troponin T3 associates with DNA consensus sequence that overlaps with p53 binding motifs. / 15.07.2018 / PubMed / Full text

TPO

Megakaryocytes promote osteoclastogenesis in aging. / 07.07.2020 / PubMed / Full text
To reflect human autoimmune thyroiditis, thyroid peroxidase (not thyroglobulin) antibodies should be measured in female (not sex-independent) NOD.H2 mice. / 04.2019 / PubMed / Full text

TREX1

Mechanistic link between DNA damage sensing, repairing and signaling factors and immune signaling. / 2019 / PubMed / Full text
Mendelian adult-onset leukodystrophy genes in Alzheimer's disease: critical influence of CSF1R and NOTCH3. / 06.2018 / PubMed / Full text

TRH

Neonatal exposure to bisphenol A alters the hypothalamic-pituitary-thyroid axis in female rats. / 15.03.2018 / PubMed / Full text
Effect of dietary carbohydrates and time of year on ACTH and cortisol concentrations in adult and aged horses. / 04.2018 / PubMed / Full text

TRPC6

Redox and mTOR-dependent regulation of plasma lamellar calcium influx controls the senescence-associated secretory phenotype. / 11.2020 / PubMed / Full text
TRPC6 in simulated microgravity of intervertebral disc cells. / 10.2018 / PubMed / Full text

TRPM7

mRNA expression of transient receptor potential melastatin (TRPM) channels 2 and 7 in perinatal brain development. / 10.2018 / PubMed / Full text
Role of kinase-coupled TRP channels in mineral homeostasis. / 04.2018 / PubMed / Full text

TRPM8

Morphological and functional changes in TRPM8-expressing corneal cold thermoreceptor neurons during aging and their impact on tearing in mice. / 01.08.2018 / PubMed / Full text
A comparative study on the therapeutic effect of TRPV1, TRPA1, and TRPM8 agonists on swallowing dysfunction associated with aging and neurological diseases. / 02.2018 / PubMed / Full text

TTN

LncRNA TTN-AS1 regulates osteosarcoma cell apoptosis and drug resistance via the miR-134-5p/MBTD1 axis. / 10.10.2019 / PubMed / Full text
Novel molecular mechanisms for the adaptogenic effects of herbal extracts on isolated brain cells using systems biology. / 15.11.2018 / PubMed / Full text

TXNRD2

Wogonin induces cellular senescence in breast cancer via suppressing TXNRD2 expression. / 10.2020 / PubMed / Full text
Loss of IDH2 Accelerates Age-related Hearing Loss in Male Mice. / 22.03.2018 / PubMed / Full text

VCAM1

Sunitinib facilitates metastatic breast cancer spreading by inducing endothelial cell senescence. / 29.09.2020 / PubMed / Full text
Aged blood impairs hippocampal neural precursor activity and activates microglia via brain endothelial cell VCAM1. / 06.2019 / PubMed / Full text

VCAN

Deletion of miR-126a Promotes Hepatic Aging and Inflammation in a Mouse Model of Cholestasis. / 07.06.2019 / PubMed / Full text
Exosomes from hyperglycemia-stimulated vascular endothelial cells contain versican that regulate calcification/senescence in vascular smooth muscle cells. / 2019 / PubMed / Full text

WFS1

Knockdown of wfs1, a fly homolog of Wolfram syndrome 1, in the nervous system increases susceptibility to age- and stress-induced neuronal dysfunction and degeneration in Drosophila. / 01.2018 / PubMed / Full text
A nonsynonymous mutation in the WFS1 gene in a Finnish family with age-related hearing impairment. / 11.2017 / PubMed / Full text

WIPI2

Neuronal autophagy declines substantially with age and is rescued by overexpression of WIPI2. / 02.2020 / PubMed / Full text
The ATG5-binding and coiled coil domains of ATG16L1 maintain autophagy and tissue homeostasis in mice independently of the WD domain required for LC3-associated phagocytosis. / 04.2019 / PubMed / Full text

XRCC1

[Protective effect of Wuzi Yanzong recipe on testicular DNA oxidative damage in natural ageing rats]. / 07.2018 / PubMed / Full text
The replicative senescent mesenchymal stem / stromal cells defect in DNA damage response and anti-oxidative capacity. / 2018 / PubMed / Full text

YAP1

[Expression relationship of Hippo signaling molecules and ovarian germline stem cell markers in the ovarian aging process of women and mice]. / 25.06.2019 / PubMed
YAP1-LATS2 feedback loop dictates senescent or malignant cell fate to maintain tissue homeostasis. / 03.2019 / PubMed / Full text

ZC3H12A

Keratinocyte-specific ablation of Mcpip1 impairs skin integrity and promotes local and systemic inflammation. / 12.2019 / PubMed / Full text
Prediction and characterization of human ageing-related proteins by using machine learning. / 06.03.2018 / PubMed / Full text

ZEB1

MicroRNA-338-5p plays a tumor suppressor role in glioma through inhibition of the MAPK-signaling pathway by binding to FOXD1. / 12.2018 / PubMed / Full text
Ultraviolet A irradiation induces senescence in human dermal fibroblasts by down-regulating DNMT1 via ZEB1. / 16.02.2018 / PubMed / Full text

ZEB2

miR-200b regulates cellular senescence and inflammatory responses by targeting ZEB2 in pulmonary emphysema. / 12.2020 / PubMed / Full text
MicroRNA-145 induces the senescence of activated hepatic stellate cells through the activation of p53 pathway by ZEB2. / 05.2019 / PubMed / Full text

ZSCAN10

RNA Exosome Complex-Mediated Control of Redox Status in Pluripotent Stem Cells. / 10.10.2017 / PubMed / Full text
ZSCAN10 expression corrects the genomic instability of iPSCs from aged donors. / 09.2017 / PubMed / Full text

AACS

Sex differences in subjective age-associated changes in sleep: a prospective elderly cohort study. / 07.11.2020 / PubMed / Full text

AANAT

Pinealectomy or light exposure exacerbates biliary damage and liver fibrosis in cholestatic rats through decreased melatonin synthesis. / 01.06.2019 / PubMed / Full text

ABCC9

TDP-43 proteinopathy in aging: Associations with risk-associated gene variants and with brain parenchymal thyroid hormone levels. / 05.2019 / PubMed / Full text

ABCE1

Widespread Accumulation of Ribosome-Associated Isolated 3' UTRs in Neuronal Cell Populations of the Aging Brain. / 27.11.2018 / PubMed / Full text

ABCG1

Disrupted cholesterol metabolism promotes age-related photoreceptor neurodegeneration. / 08.2018 / PubMed / Full text

ABCG5

2, 3, 4', 5-tetrahydroxystilbene-2-0-β-d Glycoside Attenuates Age- and Diet-Associated Non-Alcoholic Steatohepatitis and Atherosclerosis in LDL Receptor Knockout Mice and Its Possible Mechanisms. / 01.04.2019 / PubMed / Full text

ABHD12

Elevated Levels of Arachidonic Acid-Derived Lipids Including Prostaglandins and Endocannabinoids Are Present Throughout ABHD12 Knockout Brains: Novel Insights Into the Neurodegenerative Phenotype. / 2019 / PubMed / Full text

ABI3BP

Long noncoding RNA MALAT1 potentiates growth and inhibits senescence by antagonizing ABI3BP in gallbladder cancer cells. / 07.06.2019 / PubMed / Full text

ABL1

European LeukemiaNet 2020 recommendations for treating chronic myeloid leukemia. / 04.2020 / PubMed / Full text

ABLIM3

Dentate granule cell recruitment of feedforward inhibition governs engram maintenance and remote memory generalization. / 05.2018 / PubMed / Full text

ACAD10

Genome-wide association study and annotating candidate gene networks affecting age at first calving in Nellore cattle. / 12.2017 / PubMed / Full text

ACAD9

Identification of a novel mitochondrial complex I assembly factor ACDH-12 in Caenorhabditis elegans. / 05.2019 / PubMed / Full text

ACADM

High fat diet aggravates atrial and ventricular remodeling of hypertensive heart disease in aging rats. / 07.2018 / PubMed / Full text

ACAN

MicroRNA-143-5p targeting eEF2 gene mediates intervertebral disc degeneration through the AMPK signaling pathway. / 15.04.2019 / PubMed / Full text

ACAT2

Serum starvation of ARPE-19 changes the cellular distribution of cholesterol and Fibulin3 in patterns reminiscent of age-related macular degeneration. / 15.12.2017 / PubMed / Full text

ACD

Genetics of cognitive trajectory in Brazilians: 15 years of follow-up from the Bambuí-Epigen Cohort Study of Aging. / 02.12.2019 / PubMed / Full text

ACMSD

De novo NAD synthesis enhances mitochondrial function and improves health. / 11.2018 / PubMed / Full text

ACO1

Broad range metabolomics coupled with network analysis for explaining possible mechanisms of Er-Zhi-Wan in treating liver-kidney Yin deficiency syndrome of Traditional Chinese medicine. / 24.04.2019 / PubMed / Full text

ACSL5

Ageing sensitized by iPLA β deficiency induces liver fibrosis and intestinal atrophy involving suppression of homeostatic genes and alteration of intestinal lipids and bile acids. / 12.2017 / PubMed / Full text

ACTA2

Tissue Taurine Depletion Induces Profibrotic Pattern of Gene Expression and Causes Aging-Related Cardiac Fibrosis in Heart in Mice. / 2018 / PubMed / Full text

ACTR3B

Gene Expression Analysis Reveals Novel Gene Signatures Between Young and Old Adults in Human Prefrontal Cortex. / 2018 / PubMed / Full text

ACVR1

Fibrodysplasia Ossificans Progressiva (FOP): A Segmental Progeroid Syndrome. / 2019 / PubMed / Full text

ADAMTS3

Explorative results from multistep screening for potential genetic risk loci of Alzheimer's disease in the longitudinal VITA study cohort. / 01.2018 / PubMed / Full text

ADAMTS9

Proteomic profiling of follicle fluids after superstimulation in one-month-old lambs. / 02.2018 / PubMed / Full text

ADAR

Enoxacin extends lifespan of C. elegans by inhibiting miR-34-5p and promoting mitohormesis. / 09.2018 / PubMed / Full text

ADCK1

Functional analysis of Aarf domain-containing kinase 1 in Drosophila melanogaster. / 09.2019 / PubMed / Full text

ADD2

SerThr-PhosphoProteome of Brain from Aged PINK1-KO+A53T-SNCA Mice Reveals pT1928-MAP1B and pS3781-ANK2 Deficits, as Hub between Autophagy and Synapse Changes. / 04.07.2019 / PubMed / Full text

ADH1B

Telomere shortening in alcohol dependence: Roles of alcohol and acetaldehyde. / 02.2019 / PubMed / Full text

ADIPOR1

A Novel [i]Dnmt3a1[/i] Transcript Inhibits Adipogenesis. / 2018 / PubMed / Full text

ADK

Deletion of pancreatic β-cell adenosine kinase improves glucose homeostasis in young mice and ameliorates streptozotocin-induced hyperglycaemia. / 07.2019 / PubMed / Full text

ADNP

ADNP differentially interact with genes/proteins in correlation with aging: a novel marker for muscle aging. / 06.2019 / PubMed / Full text

ADNP2

ADNP differentially interact with genes/proteins in correlation with aging: a novel marker for muscle aging. / 06.2019 / PubMed / Full text

ADORA2B

Adenosine A2B receptor: A pathogenic factor and a therapeutic target for sensorineural hearing loss. / 12.2020 / PubMed / Full text

ADRA2A

α2A-Adrenergic Receptor Inhibits the Progression of Cervical Cancer Through Blocking PI3K/AKT/mTOR Pathway. / 2020 / PubMed / Full text

ADRA2B

Aging and the Combined effects of ADRA2B and CB1 deletions on Affective Working Memory. / 11.03.2019 / PubMed / Full text

ADRM1

Androgen receptor polyglutamine expansion drives age-dependent quality control defects and muscle dysfunction. / 01.08.2018 / PubMed / Full text

AGAP2

Exosomes derived from microRNA-199a-overexpressing mesenchymal stem cells inhibit glioma progression by down-regulating AGAP2. / 05.08.2019 / PubMed / Full text

AHCY

Towards frailty biomarkers: Candidates from genes and pathways regulated in aging and age-related diseases. / 11.2018 / PubMed / Full text

AIDA

Identification of Postharvest Senescence Regulators Through Map-Based Cloning Using Detached Arabidopsis Inflorescences as a Model Tissue. / 2018 / PubMed / Full text

AIF1

Sirtuin 1-Chromatin-Binding Dynamics Points to a Common Mechanism Regulating Inflammatory Targets in SIV Infection and in the Aging Brain. / 06.2018 / PubMed / Full text

AKAP12

A-Kinase Anchor Protein 12 Is Required for Oligodendrocyte Differentiation in Adult White Matter. / 05.2018 / PubMed / Full text

AKAP17A

The transcript expression levels of HNRNPM, HNRNPA0 and AKAP17A splicing factors may be predictively associated with ageing phenotypes in human peripheral blood. / 10.2019 / PubMed / Full text

AKT2

Therapeutic and preventive effects of exercise on cardiometabolic parameters in aging and obese rats. / 02.2019 / PubMed / Full text

AKT3

Oxidative stress-induced miRNAs modulate AKT signaling and promote cellular senescence in uterine leiomyoma. / 10.2018 / PubMed / Full text

AKTIP

Mice with reduced expression of the telomere-associated protein Ft1 develop p53-sensitive progeroid traits. / 08.2018 / PubMed / Full text

ALAS1

Heterozygous disruption of ALAS1 in mice causes an accelerated age-dependent reduction in free heme, but not total heme, in skeletal muscle and liver. / 08.12.2020 / PubMed / Full text

ALDH3A1

Hallmarks of the cancer cell of origin: Comparisons with "energetic" cancer stem cells (e-CSCs). / 13.02.2019 / PubMed / Full text

ALDOA

An Adult Drosophila Glioma Model for Studying Pathometabolic Pathways of Gliomagenesis. / 06.2019 / PubMed / Full text

ALK

Catalog of Lung Cancer Gene Mutations Among Chinese Patients. / 2020 / PubMed / Full text

ALKBH1

ALKB-8, a 2-Oxoglutarate-Dependent Dioxygenase and S-Adenosine Methionine-Dependent Methyltransferase Modulates Metabolic Events Linked to Lysosome-Related Organelles and Aging in C. elegans. / 2018 / PubMed

ALKBH2

ALKB-8, a 2-Oxoglutarate-Dependent Dioxygenase and S-Adenosine Methionine-Dependent Methyltransferase Modulates Metabolic Events Linked to Lysosome-Related Organelles and Aging in C. elegans. / 2018 / PubMed

ALOX12

Arachidonate 12-lipoxygenase and 12-hydroxyeicosatetraenoic acid contribute to stromal aging-induced progression of pancreatic cancer. / 15.05.2020 / PubMed / Full text

ALOX5

Functional Characterization of Knock-In Mice Expressing a 12/15-Lipoxygenating Alox5 Mutant Instead of the 5-Lipoxygenating Wild-Type Enzyme. / 01.01.2020 / PubMed / Full text

AMFR

Mice heterozygous for the Cdh23/Ahl1 mutation show age-related deficits in auditory temporal processing. / 09.2019 / PubMed / Full text

AMHR2

Long-lived rodents reveal signatures of positive selection in genes associated with lifespan. / 03.2018 / PubMed / Full text

AMPH

Effects of amphetamine exposure during adolescence on behavior and prelimbic cortex neuron activity in adulthood. / 01.09.2018 / PubMed / Full text

ANG

Age-related differences in the cutaneous vascular response to exogenous angiotensin II. / 01.03.2019 / PubMed / Full text

ANGPT2

Systemic analysis of gene expression profiles in porcine granulosa cells during aging. / 14.11.2017 / PubMed / Full text

ANGPTL4

Involvement of ERK1/2 activation in the gene expression of senescence-associated secretory factors in human hepatic stellate cells. / 05.2019 / PubMed / Full text

ANK2

SerThr-PhosphoProteome of Brain from Aged PINK1-KO+A53T-SNCA Mice Reveals pT1928-MAP1B and pS3781-ANK2 Deficits, as Hub between Autophagy and Synapse Changes. / 04.07.2019 / PubMed / Full text

ANK3

Age-related atrophy of cortical thickness and genetic effect of ANK3 gene in first episode MDD patients. / 26.08.2020 / PubMed / Full text

ANKS1B

Explorative results from multistep screening for potential genetic risk loci of Alzheimer's disease in the longitudinal VITA study cohort. / 01.2018 / PubMed / Full text

ANPEP

Aminopeptidase N expression in the endometrium could affect endometrial receptivity. / 25.06.2019 / PubMed / Full text

ANXA1

Assessment of Human Skin Gene Expression by Different Blends of Plant Extracts with Implications to Periorbital Skin Aging. / 26.10.2018 / PubMed / Full text

AOX1

N1-Methylnicotinamide: An Anti-Ovarian Aging Hormetin? / 09.2020 / PubMed / Full text

AP2B1

Circular RNA NF1-419 enhances autophagy to ameliorate senile dementia by binding Dynamin-1 and Adaptor protein 2 B1 in AD-like mice. / 20.12.2019 / PubMed / Full text

APLNR

Endothelial APLNR regulates tissue fatty acid uptake and is essential for apelin's glucose-lowering effects. / 13.09.2017 / PubMed / Full text

APLP2

Analysis of Motor Function in Amyloid Precursor-Like Protein 2 Knockout Mice: The Effects of Ageing and Sex. / 06.2019 / PubMed / Full text

APOA1

Effects of iron on the aggregation propensity of the N-terminal fibrillogenic polypeptide of human apolipoprotein A-I. / 08.2018 / PubMed / Full text

APOBEC1

Loss of APOBEC1 RNA-editing function in microglia exacerbates age-related CNS pathophysiology. / 12.12.2017 / PubMed / Full text

APOC1

Genetics of Human Longevity From Incomplete Data: New Findings From the Long Life Family Study. / 08.10.2018 / PubMed / Full text

APOC3

Positional Obstructive Sleep Apnea Syndrome in Elderly Patients. / 10.02.2020 / PubMed / Full text

APPL1

Insulin and adipokine signaling and their cross-regulation in postmortem human brain. / 12.2019 / PubMed / Full text

AQP2

A bell-shaped pattern of urinary aquaporin-2-bearing extracellular vesicle release in an experimental model of nephronophthisis. / 05.2019 / PubMed / Full text

AQP4

Overexpression of Slit2 improves function of the paravascular pathway in the aging mouse brain. / 10.2018 / PubMed / Full text

AQP5

Submandibular gland-specific inflammaging-induced hyposalivation in the male senescence-accelerated mouse prone -1 line (SAM-P1). / 08.2019 / PubMed / Full text

ARHGAP18

Stress-Induced Premature Senescence Promotes Proliferation by Activating the [i]SENEX[/i] and p16 /Retinoblastoma (Rb) Pathway in Diffuse Large B-Cell Lymphoma / 18.11.2019 / PubMed / Full text

ARID1B

A 69-year-old woman with Coffin-Siris syndrome. / 08.2018 / PubMed / Full text

ARID5A

Differentially regulated gene expression in quiescence versus senescence and identification of ARID5A as a quiescence associated marker. / 05.2018 / PubMed / Full text

ARL13B

ARL13B, a Joubert Syndrome-Associated Protein, Is Critical for Retinogenesis and Elaboration of Mouse Photoreceptor Outer Segments. / 20.02.2019 / PubMed / Full text

ARNTL

Is the aging human ovary still ticking?: Expression of clock-genes in luteinized granulosa cells of young and older women. / 21.11.2018 / PubMed / Full text

ARNTL2

Is the aging human ovary still ticking?: Expression of clock-genes in luteinized granulosa cells of young and older women. / 21.11.2018 / PubMed / Full text

ARRB2

Age-dependent effects of dopamine receptor inactivation on cocaine-induced behaviors in male rats: Evidence of dorsal striatal D2 receptor supersensitivity. / 12.2019 / PubMed / Full text

ARSA

Mendelian adult-onset leukodystrophy genes in Alzheimer's disease: critical influence of CSF1R and NOTCH3. / 06.2018 / PubMed / Full text

ASB3

Longitudinal analysis of bronchodilator response in asthmatics and effect modification of age-related trends by genotype. / 02.2019 / PubMed / Full text

ASB7

ASB7 Is a Novel Regulator of Cytoskeletal Organization During Oocyte Maturation. / 2020 / PubMed / Full text

ASIP

Efficacy of an agonist of α-MSH, the palmitoyl tetrapeptide-20, in hair pigmentation. / 10.2018 / PubMed / Full text

ASMT

The influence of ageing on the extrapineal melatonin synthetic pathway. / 09.2018 / PubMed / Full text

ASPA

Effect of adding B-vitamins to vitamin D and calcium supplementation on CpG methylation of epigenetic aging markers. / 04.2018 / PubMed / Full text

ATF2

Transcriptional regulation of stress kinase JNK2 in pro-arrhythmic CaMKIIδ expression in the aged atrium. / 01.04.2018 / PubMed / Full text

ATF3

ATF3 represses PINK1 gene transcription in lung epithelial cells to control mitochondrial homeostasis. / 04.2018 / PubMed / Full text

ATF7

Stress-induced and ATF7-dependent epigenetic change influences cellular senescence. / 09.2019 / PubMed / Full text

ATG10

Genetic associations with age of menopause in familial longevity. / 10.2019 / PubMed / Full text

ATG16L1

The ATG5-binding and coiled coil domains of ATG16L1 maintain autophagy and tissue homeostasis in mice independently of the WD domain required for LC3-associated phagocytosis. / 04.2019 / PubMed / Full text

ATG4B

Impaired autophagic activity and ATG4B deficiency are associated with increased endoplasmic reticulum stress-induced lung injury. / 27.08.2018 / PubMed / Full text

ATG4D

Reduction of Aging-Induced Oxidative Stress and Activation of Autophagy by Bilberry Anthocyanin Supplementation via the AMPK-mTOR Signaling Pathway in Aged Female Rats. / 17.07.2019 / PubMed / Full text

ATP1A2

SerThr-PhosphoProteome of Brain from Aged PINK1-KO+A53T-SNCA Mice Reveals pT1928-MAP1B and pS3781-ANK2 Deficits, as Hub between Autophagy and Synapse Changes. / 04.07.2019 / PubMed / Full text

ATP2B1

Reduced expression of PMCA1 is associated with increased blood pressure with age which is preceded by remodelling of resistance arteries. / 10.2017 / PubMed / Full text

ATP6V0C

A pH probe inhibits senescence in mesenchymal stem cells. / 07.12.2018 / PubMed / Full text

ATP6V1E1

Low expression of aging-related [[NRXN3]] is associated with Alzheimer disease: A systematic review and meta-analysis. / 07.2018 / PubMed / Full text

ATXN1

Integrative Analysis of Hippocampus Gene Expression Profiles Identifies Network Alterations in Aging and Alzheimer's Disease. / 2018 / PubMed / Full text

ATXN3

Rescue of ATXN3 neuronal toxicity in [i]Caenorhabditis[/i][i]elegans[/i] by chemical modification of endoplasmic reticulum stress. / 19.12.2017 / PubMed / Full text

AXL

Extracellular acidosis triggers a senescence-like phenotype in human melanoma cells. / 01.2020 / PubMed / Full text

BACH2

Age-related changes in the BACH2 and PRDM1 genes in lymphocytes from healthy donors and chronic lymphocytic leukemia patients. / 17.01.2019 / PubMed / Full text

BAG3

Nrf2 mediates the expression of BAG3 and autophagy cargo adaptor proteins and tau clearance in an age-dependent manner. / 03.2018 / PubMed / Full text

BANF1

An additional case of Néstor-Guillermo progeria syndrome diagnosed in early childhood. / 10.2020 / PubMed / Full text

BARD1

BRCA1 and BARD1 mediate apoptotic resistance but not longevity upon mitochondrial stress in [i]Caenorhabditis elegans[/i]. / 12.2018 / PubMed / Full text

BAZ1A

Chromatin remodeling factor BAZ1A regulates cellular senescence in both cancer and normal cells. / 15.07.2019 / PubMed / Full text

BAZ2B

Two conserved epigenetic regulators prevent healthy ageing. / 03.2020 / PubMed / Full text

BBS5

Progressive Characterization of Visual Phenotype in Bardet-Biedl Syndrome Mutant Mice. / 01.03.2019 / PubMed / Full text

BCAS1

Hallmarks of the cancer cell of origin: Comparisons with "energetic" cancer stem cells (e-CSCs). / 13.02.2019 / PubMed / Full text

BCL11B

Responders and non-responders to influenza vaccination: A DNA methylation approach on blood cells. / 05.2018 / PubMed / Full text

BCL2L1

SIRT6 histone deacetylase functions as a potential oncogene in human melanoma. / 09.2017 / PubMed / Full text

BCL2L11

miRNA expression profiling uncovers a role of miR-302b-3p in regulating skin fibroblasts senescence. / 01.2020 / PubMed / Full text

BHLHE40

Thyroid hormone induces cellular senescence in prostate cancer cells through induction of DEC1. / 07.2020 / PubMed / Full text

BMP6

Noggin rescues age-related stem cell loss in the brain of senescent mice with neurodegenerative pathology. / 06.11.2018 / PubMed / Full text

BMP7

Downregulation of miR-542-3p promotes osteogenic transition of vascular smooth muscle cells in the aging rat by targeting BMP7. / 11.12.2019 / PubMed / Full text

BMPR1B

Growth hormone during in vitro fertilization in older women modulates the density of receptors in granulosa cells, with improved pregnancy outcomes. / 12.2018 / PubMed / Full text

BMPR2

Centenarians Overexpress Pluripotency-Related Genes. / 16.08.2019 / PubMed / Full text

BNC1

Basonuclin 1 deficiency causes testicular premature aging: BNC1 cooperates with TAF7L to regulate spermatogenesis. / 22.01.2020 / PubMed / Full text

BOC

Protein Requirements of Elderly Chinese Adults Are Higher than Current Recommendations. / 01.05.2020 / PubMed / Full text

BRD2

Brd2 haploinsufficiency extends lifespan and healthspan in C57B6/J mice. / 2020 / PubMed / Full text

BRD3

Neuroprotective effects of targeting BET proteins for degradation with dBET1 in aged mice subjected to ischemic stroke. / 07.2019 / PubMed / Full text

BTC

Behavioral tagging and capture: long-term memory decline in middle-aged rats. / 07.2018 / PubMed / Full text

BTG1

Tumor cell escape from therapy-induced senescence. / 04.2019 / PubMed / Full text

C2CD2

Genetic variants associated with physical performance and anthropometry in old age: a genome-wide association study in the ilSIRENTE cohort. / 20.11.2017 / PubMed / Full text

CA12

Co-culturing nucleus pulposus mesenchymal stem cells with notochordal cell-rich nucleus pulposus explants attenuates tumor necrosis factor-α-induced senescence. / 26.06.2018 / PubMed / Full text

CABLES1

CABLES1 Deficiency Impairs Quiescence and Stress Responses of Hematopoietic Stem Cells in Intrinsic and Extrinsic Manners. / 13.08.2019 / PubMed / Full text

CACNA1B

Epigenome-wide exploratory study of monozygotic twins suggests differentially methylated regions to associate with hand grip strength. / 10.2019 / PubMed / Full text

CACNA1S

Increased calcium channel in the lamina propria of aging rat. / 31.10.2019 / PubMed / Full text

CALR

Molecular Pathogenesis of Myeloproliferative Neoplasms: Influence of Age and Gender. / 10.2017 / PubMed / Full text

CAMSAP1

Gene Expression Analysis Reveals Novel Gene Signatures Between Young and Old Adults in Human Prefrontal Cortex. / 2018 / PubMed / Full text

CAP2

Targeting MRTF/SRF in CAP2-dependent dilated cardiomyopathy delays disease onset. / 21.03.2019 / PubMed / Full text

CAPRIN1

Reduced Levels of the Synaptic Functional Regulator FMRP in Dentate Gyrus of the Aging Sprague-Dawley Rat. / 2017 / PubMed / Full text

CARF

Induction of Senescence in Cancer Cells by a Novel Combination of Cucurbitacin B and Withanone: Molecular Mechanism and Therapeutic Potential. / 22.05.2020 / PubMed / Full text

CARM1

CARM1 regulates senescence during airway epithelial cell injury in COPD pathogenesis. / 01.11.2019 / PubMed / Full text

CASK

Integrated study on comparative transcriptome and skeletal muscle function in aged rats. / 01.2018 / PubMed / Full text

CASP3

Does cartilage ERα overexpression correlate with osteoarthritic chondrosenescence? Indications from [i]Labisia pumila[/i] OA mitigation. / 09.2019 / PubMed

CASS4

Genetic Biomarkers on Age-Related Cognitive Decline. / 2017 / PubMed / Full text

CAV1

Broad range metabolomics coupled with network analysis for explaining possible mechanisms of Er-Zhi-Wan in treating liver-kidney Yin deficiency syndrome of Traditional Chinese medicine. / 24.04.2019 / PubMed / Full text

CBX3

Biological functions of chromobox (CBX) proteins in stem cell self-renewal, lineage-commitment, cancer and development. / 24.09.2020 / PubMed / Full text

CBX4

Maintenance of Nucleolar Homeostasis by CBX4 Alleviates Senescence and Osteoarthritis. / 26.03.2019 / PubMed / Full text

CBX8

PIM1-catalyzed CBX8 phosphorylation promotes the oncogene-induced senescence of human diploid fibroblast. / 27.06.2018 / PubMed / Full text

CCAR2

CCAR-1 is a negative regulator of the heat-shock response in Caenorhabditis elegans. / 10.2018 / PubMed / Full text

CCDC88A

Proteomics and metabolomics identify molecular mechanisms of aging potentially predisposing for chronic lymphocytic leukemia. / 02.2018 / PubMed / Full text

CCL13

Age-specific changes in the molecular phenotype of patients with moderate-to-severe atopic dermatitis. / 07.2019 / PubMed / Full text

CCL18

Age-specific changes in the molecular phenotype of patients with moderate-to-severe atopic dermatitis. / 07.2019 / PubMed / Full text

CCL19

Age-Related Gliosis Promotes Central Nervous System Lymphoma through CCL19-Mediated Tumor Cell Retention. / 16.09.2019 / PubMed / Full text

CCL28

Age-related chemokine alterations affect IgA secretion and gut immunity in female mice. / 10.2020 / PubMed / Full text

CCN4

CCN proteins as potential actionable targets in scleroderma. / 01.2019 / PubMed / Full text

CCNA1

Age-dependent human β cell proliferation induced by glucagon-like peptide 1 and calcineurin signaling. / 02.10.2017 / PubMed / Full text

CCNA2

Hypoxia Upregulates Mitotic Cyclins Which Contribute to the Multipotency of Human Mesenchymal Stem Cells by Expanding Proliferation Lifespan. / 31.03.2018 / PubMed / Full text

CCND1

Effects of hydrogen peroxide, doxorubicin and ultraviolet irradiation on senescence of human dental pulp stem cells. / 09.2020 / PubMed / Full text

CCND2

Oxidative stress-induced miRNAs modulate AKT signaling and promote cellular senescence in uterine leiomyoma. / 10.2018 / PubMed / Full text

CCND3

The effect of aging on the biological and immunological characteristics of periodontal ligament stem cells. / 29.07.2020 / PubMed / Full text

CCR3

Low Molecular Weight Hyaluronan Induces an Inflammatory Response in Ovarian Stromal Cells and Impairs Gamete Development In Vitro. / 04.02.2020 / PubMed / Full text

CD2

Adaptive NKG2C CD57 Natural Killer Cell and Tim-3 Expression During Viral Infections. / 2018 / PubMed / Full text

CD209

Comparative analysis of microbial sensing molecules in mucosal tissues with aging. / 03.2018 / PubMed / Full text

CD226

T-cell Immunoglobulin and ITIM Domain Contributes to CD8 T-cell Immunosenescence. / 04.2018 / PubMed / Full text

CD2AP

Recent studies on cellular and molecular mechanisms in Alzheimer's disease: focus on epigenetic factors and histone deacetylase. / 28.03.2018 / PubMed / Full text

CD48

Genetic overexpression of COMP-Ang1 impairs BM microenvironment and induces senescence of BM HSCs. / 15.05.2018 / PubMed / Full text

CD55

Loss of complement regulatory proteins on uninfected erythrocytes in vivax and falciparum malaria anemia. / 15.11.2018 / PubMed / Full text

CD59

Red Blood Cell Homeostasis and Altered Vesicle Formation in Patients With Paroxysmal Nocturnal Hemoglobinuria. / 2019 / PubMed / Full text

CD72

Crucial Role of Increased Arid3a at the Pre-B and Immature B Cell Stages for B1a Cell Generation. / 2019 / PubMed / Full text

CD82

Cell-surface phenotyping identifies CD36 and CD97 as novel markers of fibroblast quiescence in lung fibrosis. / 01.11.2018 / PubMed / Full text

CDC20

Premature aging syndrome showing random chromosome number instabilities with CDC20 mutation. / 11.2020 / PubMed / Full text

CDC25A

Babam2 Regulates Cell Cycle Progression and Pluripotency in Mouse Embryonic Stem Cells as Revealed by Induced DNA Damage. / 10.10.2020 / PubMed / Full text

CDC6

A prototypical non-malignant epithelial model to study genome dynamics and concurrently monitor micro-RNAs and proteins in situ during oncogene-induced senescence. / 10.01.2018 / PubMed / Full text

CDC73

Down-regulation of cancer-associated gene CDC73 contributes to cellular senescence. / 23.05.2018 / PubMed / Full text

CDH1

Cdc6 as a novel target in cancer: Oncogenic potential, senescence and subcellular localisation. / 15.09.2020 / PubMed / Full text

CDH2

CellBIC: bimodality-based top-down clustering of single-cell RNA sequencing data reveals hierarchical structure of the cell type. / 30.11.2018 / PubMed / Full text

CDKN1B

A Novel [i]Dnmt3a1[/i] Transcript Inhibits Adipogenesis. / 2018 / PubMed / Full text

CDKN1C

Human iPSC-derived MSCs (iMSCs) from aged individuals acquire a rejuvenation signature. / 18.03.2019 / PubMed / Full text

CDO1

The intervention effect of licorice in d-galactose induced aging rats by regulating the taurine metabolic pathway. / 19.09.2018 / PubMed / Full text

CDR1

Two Distinct Pathways in Mice Generate Antinuclear Antigen-Reactive B Cell Repertoires. / 2018 / PubMed / Full text

CDX2

Maternal ageing impairs mitochondrial DNA kinetics during early embryogenesis in mice. / 08.07.2019 / PubMed / Full text

CEBPB

Integrative Analysis of Hippocampus Gene Expression Profiles Identifies Network Alterations in Aging and Alzheimer's Disease. / 2018 / PubMed / Full text

CEBPD

Epigenome-wide exploratory study of monozygotic twins suggests differentially methylated regions to associate with hand grip strength. / 10.2019 / PubMed / Full text

CEL

Nanocarrier-Mediated Chemo-Immunotherapy Arrested Cancer Progression and Induced Tumor Dormancy in Desmoplastic Melanoma. / 28.08.2018 / PubMed / Full text

CES1

[Comparative Study of Hydrolase Activity in Skin with Liver and Intestine, and Its Aging Relation of Carboxylesterase Expression in Cynomolgus Monkey and Beagle Dog]. / 2019 / PubMed / Full text

CETP

Biomarkers and Gene Polymorphisms in Members of Long- and Short-lived Families: A Longevity Study. / 2018 / PubMed / Full text

CFB

The expression of C1 inhibitor (C1INH) in macrophages is upregulated by retinal pigment epithelial cells - implication in subretinal immune privilege in the aging eye. / 13.06.2018 / PubMed / Full text

CFH

The expression of C1 inhibitor (C1INH) in macrophages is upregulated by retinal pigment epithelial cells - implication in subretinal immune privilege in the aging eye. / 13.06.2018 / PubMed / Full text

CHAT

Satisfaction and Technology Evaluation of a Telehealth Robotic Program to Optimize Healthy Independent Living for Older Adults. / 11.2018 / PubMed / Full text

CHEK2

A large-scale CRISPR screen and identification of essential genes in cellular senescence bypass. / 20.06.2019 / PubMed / Full text

CHIA

Lipoprotein Profile in Aged Rats Fed Chia Oil- or Hydroxytyrosol-Enriched Pork in High Cholesterol/High Saturated Fat Diets. / 26.11.2018 / PubMed / Full text

CHL1

Close Homolog of L1 Regulates Dendritic Spine Density in the Mouse Cerebral Cortex Through Semaphorin 3B. / 07.08.2019 / PubMed / Full text

CHRM4

Novel molecular mechanisms for the adaptogenic effects of herbal extracts on isolated brain cells using systems biology. / 15.11.2018 / PubMed / Full text

CHRNA7

Associations between genetic variations and global motion perception. / 10.2019 / PubMed / Full text

CHRNE

Novel molecular mechanisms for the adaptogenic effects of herbal extracts on isolated brain cells using systems biology. / 15.11.2018 / PubMed / Full text

CHSY1

Loss of Chondroitin Sulfate Modification Causes Inflammation and Neurodegeneration in [i]skt[/i] Mice. / 01.2020 / PubMed / Full text

CINP

Neuropathology-driven Whole-genome Sequencing Study Points to Novel Candidate Genes for Healthy Brain Aging. / 01-03.2019 / PubMed / Full text

CIP2A

Inhibition of CIP2A attenuates tumor progression by inducing cell cycle arrest and promoting cellular senescence in hepatocellular carcinoma. / 08.01.2018 / PubMed / Full text

CIZ1

DNA damage and neurodegenerative phenotypes in aged Ciz1 null mice. / 02.2018 / PubMed / Full text

CLEC3B

CLEC3B p.S106G Mutant in a Caucasian Population of Successful Neurological Aging. / 16.09.2020 / PubMed / Full text

CLEC4E

Comparative analysis of microbial sensing molecules in mucosal tissues with aging. / 03.2018 / PubMed / Full text

CLN3

SIRT6 histone deacetylase functions as a potential oncogene in human melanoma. / 09.2017 / PubMed / Full text

CNP

Environmental Enrichment Elicits a Transient Rise of Bioactive C-Type Natriuretic Peptide in Young but Not Aged Rats. / 2018 / PubMed / Full text

CNTF

Absence of axonal sprouting following unilateral lesion in 125-day-old rat supraoptic nucleus may be due to age-dependent decrease in protein levels of ciliary neurotrophic factor receptor alpha. / 01.10.2019 / PubMed / Full text

CNTNAP2

Selective molecular biomarkers to predict biologic behavior in pituitary tumors. / 05.2017 / PubMed / Full text

COL12A1

Genetic associations with age of menopause in familial longevity. / 10.2019 / PubMed / Full text

COL13A1

[Alu insertion-deletion polymorphism of COL13A1 and LAMA2 genes: The analysis of association with longevity]. / 10.2016 / PubMed

COL1A1

Remodeling process in bone of aged rats in response to resistance training. / 01.09.2020 / PubMed / Full text

COL2A1

Inhibition of Wnt/β-catenin signaling ameliorates osteoarthritis in a murine model of experimental osteoarthritis. / 08.02.2018 / PubMed / Full text

COL6A1

Epigenome-wide exploratory study of monozygotic twins suggests differentially methylated regions to associate with hand grip strength. / 10.2019 / PubMed / Full text

COQ5

Reduction in the levels of CoQ biosynthetic proteins is related to an increase in lifespan without evidence of hepatic mitohormesis. / 18.09.2018 / PubMed / Full text

COQ6

Reduction in the levels of CoQ biosynthetic proteins is related to an increase in lifespan without evidence of hepatic mitohormesis. / 18.09.2018 / PubMed / Full text

COQ7

Reduction in the levels of CoQ biosynthetic proteins is related to an increase in lifespan without evidence of hepatic mitohormesis. / 18.09.2018 / PubMed / Full text

COQ9

Reduction in the levels of CoQ biosynthetic proteins is related to an increase in lifespan without evidence of hepatic mitohormesis. / 18.09.2018 / PubMed / Full text

CPNE1

Prevalent intron retention fine-tunes gene expression and contributes to cellular senescence. / 04.12.2020 / PubMed / Full text

CPT1A

Alteration of fatty acid oxidation by increased CPT1A on replicative senescence of placenta-derived mesenchymal stem cells. / 03.01.2020 / PubMed / Full text

CPT1B

Effects of carnitine palmitoyltransferases on cancer cellular senescence. / 02.2019 / PubMed / Full text

CPT2

The phytochemical epigallocatechin gallate prolongs the lifespan by improving lipid metabolism, reducing inflammation and oxidative stress in high-fat diet-fed obese rats. / 09.2020 / PubMed / Full text

CR2

Age-related but not longevity-related genes are found by weighted gene co-expression network analysis in the peripheral blood cells of humans. / 19.01.2019 / PubMed / Full text

CRBN

Using proteolysis-targeting chimera technology to reduce navitoclax platelet toxicity and improve its senolytic activity. / 24.04.2020 / PubMed / Full text

CREB1

Arginine Methyltransferase PRMT8 Provides Cellular Stress Tolerance in Aging Motoneurons. / 29.08.2018 / PubMed / Full text

CREB5

Cellular senescence induces replication stress with almost no affect on DNA replication timing. / 2018 / PubMed / Full text

CREBBP

Systems biology and network pharmacology of frailty reveal novel epigenetic targets and mechanisms. / 22.07.2019 / PubMed / Full text

CREM

Ageing in men with normal spermatogenesis alters spermatogonial dynamics and nuclear morphology in Sertoli cells. / 11.2019 / PubMed / Full text

CRISPLD2

A large-scale CRISPR screen and identification of essential genes in cellular senescence bypass. / 20.06.2019 / PubMed / Full text

CRY2

Is the aging human ovary still ticking?: Expression of clock-genes in luteinized granulosa cells of young and older women. / 21.11.2018 / PubMed / Full text

CRYAB

Binding of a glaucoma-associated myocilin variant to the αB-crystallin chaperone impedes protein clearance in trabecular meshwork cells. / 28.12.2018 / PubMed / Full text

CSAD

The intervention effect of licorice in d-galactose induced aging rats by regulating the taurine metabolic pathway. / 19.09.2018 / PubMed / Full text

CSF3R

Both Granulocytic and Non-Granulocytic Blood Cells Are Affected in Patients with Severe Congenital Neutropenia and Their Non-Neutropenic Family Members: An Evaluation of Morphology, Function, and Cell Death / 13.11.2018 / PubMed / Full text

CTC1

CTC1-STN1 coordinates G- and C-strand synthesis to regulate telomere length. / 08.2018 / PubMed / Full text

CTNS

Reducing INS-IGF1 signaling protects against non-cell autonomous vesicle rupture caused by SNCA spreading. / 05.2020 / PubMed / Full text

CTSA

A CTSA-based consultation service to advance research on special and underserved populations. / 16.01.2020 / PubMed / Full text

CTSL

Cathepsin L deficiency results in reactive oxygen species (ROS) accumulation and vascular cells activation. / 12.2017 / PubMed / Full text

CTSS

SIRT6 histone deacetylase functions as a potential oncogene in human melanoma. / 09.2017 / PubMed / Full text

CUL3

KLHL22 activates amino-acid-dependent mTORC1 signalling to promote tumorigenesis and ageing. / 05.2018 / PubMed / Full text

CUX1

Identification of key genes and transcription factors in aging mesenchymal stem cells by DNA microarray data. / 15.04.2019 / PubMed / Full text

CXCL13

RNA-seq data from C-X-C chemokine receptor type 5 (CXCR5) gene knockout aged mice with retinal degeneration phenotype. / 08.2020 / PubMed / Full text

CXCL14

Identification of genes associated with endometrial cell aging. / 01.12.2020 / PubMed / Full text

CXCL16

CXCR6 Inhibits Hepatocarcinogenesis by Promoting Natural Killer T- and CD4 T-Cell-Dependent Control of Senescence. / 05.2019 / PubMed / Full text

CXCL17

[Age-related aspects of the involvement of heat shock proteins in the pathogenesis of osteoarthritis]. / 2017 / PubMed

CXCR1

Harmful neutrophil subsets in patients with ischemic stroke: Association with disease severity. / 07.2019 / PubMed / Full text

CXCR5

Altered marginal zone and innate-like B cells in aged senescence-accelerated SAMP8 mice with defective IgG1 responses. / 17.08.2017 / PubMed / Full text

CXCR6

CXCR6 Inhibits Hepatocarcinogenesis by Promoting Natural Killer T- and CD4 T-Cell-Dependent Control of Senescence. / 05.2019 / PubMed / Full text

CYB5A

11-Oxygenated C19 Steroids Do Not Decline With Age in Women. / 01.07.2019 / PubMed / Full text

CYB5R3

Overexpression of CYB5R3 and NQO1, two NAD -producing enzymes, mimics aspects of caloric restriction. / 08.2018 / PubMed / Full text

CYP11B1

Intratumoral heterogeneity of the tumor cells based on in situ cortisol excess in cortisol-producing adenomas; ∼An association among morphometry, genotype and cellular senescence∼. / 11.2020 / PubMed / Full text

CYP11B2

Expression of aldosterone synthase CYP11B2 was inversely correlated with longevity. / 07.2019 / PubMed / Full text

CYP17A1

Combined toxicity of endosulfan and phenanthrene mixtures and induced molecular changes in adult Zebrafish (Danio rerio). / 03.2018 / PubMed / Full text

CYP19A1

Vitamin D3 mediated regulation of steroidogenesis mitigates testicular activity in an aged rat model. / 06.2019 / PubMed / Full text

CYP1B1

Bisphenol A induces DSB-ATM-p53 signaling leading to cell cycle arrest, senescence, autophagy, stress response, and estrogen release in human fetal lung fibroblasts. / 04.2018 / PubMed / Full text

CYP24A1

Oleanolic Acid Exerts Osteoprotective Effects and Modulates Vitamin D Metabolism. / 22.02.2018 / PubMed / Full text

CYP26A1

Genetics of Human Longevity From Incomplete Data: New Findings From the Long Life Family Study. / 08.10.2018 / PubMed / Full text

CYP26B1

Increased Retinoic Acid Catabolism in Olfactory Sensory Neurons Activates Dormant Tissue-Specific Stem Cells and Accelerates Age-Related Metaplasia. / 20.05.2020 / PubMed / Full text

CYP2C9

Pediatric Cytochrome P450 Activity Alterations in Nonalcoholic Steatohepatitis. / 12.2017 / PubMed / Full text

CYP2R1

Decreased Serum 25-Hydroxyvitamin D in Aging Male Mice Is Associated With Reduced Hepatic Cyp2r1 Abundance. / 01.08.2018 / PubMed / Full text

CYP3A5

Effect of Age and Allele Variants of CYP3A5, CYP3A4, and POR Genes on the Pharmacokinetics of Cyclosporin A in Pediatric Renal Transplant Recipients From Serbia. / 12.2017 / PubMed / Full text

DAP

Examining changes in the equity of physician distribution in Japan: a specialty-specific longitudinal study. / 08.01.2018 / PubMed / Full text

DAPK2

SerThr-PhosphoProteome of Brain from Aged PINK1-KO+A53T-SNCA Mice Reveals pT1928-MAP1B and pS3781-ANK2 Deficits, as Hub between Autophagy and Synapse Changes. / 04.07.2019 / PubMed / Full text

DAXX

ATRX-DAXX Complex Expression Levels and Telomere Length in Normal Young and Elder Autopsy Human Brains. / 09.2019 / PubMed / Full text

DAZL

DAZL Regulates Germ Cell Survival through a Network of PolyA-Proximal mRNA Interactions. / 30.10.2018 / PubMed / Full text

DBH

ADHD risk genes involved in dopamine signaling and metabolism are associated with reduced estimated life expectancy at young adult follow-up in hyperactive and control children. / 04.2019 / PubMed / Full text

DBT

Diurnal rhythms of heart and respiratory rates in donkeys of different age groups during the cold-dry and hot-dry seasons in a tropical savannah. / 09.2018 / PubMed / Full text

DCAF17

Deletion of DDB1- and CUL4- associated factor-17 (Dcaf17) gene causes spermatogenesis defects and male infertility in mice. / 15.06.2018 / PubMed / Full text

DCLRE1C

Polymorphisms of the DNA repair gene EXO1 modulate cognitive aging in old adults in a Taiwanese population. / 06.2019 / PubMed / Full text

DCTN2

Dynactin pathway-related gene expression is altered by aging, but not by vitrification. / 09.2019 / PubMed / Full text

DCTN3

Dynactin pathway-related gene expression is altered by aging, but not by vitrification. / 09.2019 / PubMed / Full text

DCTN6

Dynactin pathway-related gene expression is altered by aging, but not by vitrification. / 09.2019 / PubMed / Full text

DDI2

Androgen receptor polyglutamine expansion drives age-dependent quality control defects and muscle dysfunction. / 01.08.2018 / PubMed / Full text

DDIT3

Inhibition of glioma growth by flavokawain B is mediated through endoplasmic reticulum stress induced autophagy. / 2018 / PubMed / Full text

DDR1

Age-related modifications of type I collagen impair DDR1-induced apoptosis in non-invasive breast carcinoma cells. / 2018 / PubMed / Full text

DDR2

Selective Role of Discoidin Domain Receptor 2 in Murine Temporomandibular Joint Development and Aging. / 03.2018 / PubMed / Full text

DEPDC5

KLHL22 activates amino-acid-dependent mTORC1 signalling to promote tumorigenesis and ageing. / 05.2018 / PubMed / Full text

DEPTOR

DEPTOR at the Nexus of Cancer, Metabolism, and Immunity. / 01.07.2018 / PubMed / Full text

DES

Increased circulating desmosine and age-dependent elastinolysis in idiopathic pulmonary fibrosis. / 20.03.2018 / PubMed / Full text

DGAT1

Ghrelin deletion protects against age-associated hepatic steatosis by downregulating the C/EBPα-p300/DGAT1 pathway. / 02.2018 / PubMed / Full text

DGAT2

Expression of lipogenic markers is decreased in subcutaneous adipose tissue and adipocytes of older women and is negatively linked to GDF15 expression. / 08.2019 / PubMed / Full text

DGCR8

HPV shapes tumor transcriptome by globally modifying the pool of RNA binding protein-binding motif. / 29.04.2019 / PubMed / Full text

DHRS2

Acute HSF1 depletion induces cellular senescence through the MDM2-p53-p21 pathway in human diploid fibroblasts. / 08.05.2018 / PubMed / Full text

DIAPH1

Diaphanous 1 (DIAPH1) is Highly Expressed in the Aged Human Medial Temporal Cortex and Upregulated in Myeloid Cells During Alzheimer's Disease. / 2018 / PubMed / Full text

DIP2A

Blocking the FSTL1-DIP2A Axis Improves Anti-tumor Immunity. / 14.08.2018 / PubMed / Full text

DKK2

Low Serum Levels of DKK2 Predict Incident Low-Impact Fracture in Older Women. / 07.2019 / PubMed / Full text

DLAT

Proteomics and metabolomics identify molecular mechanisms of aging potentially predisposing for chronic lymphocytic leukemia. / 02.2018 / PubMed / Full text

DLC1

Resveratrol promotes oxidative stress to drive DLC1 mediated cellular senescence in cancer cells. / 15.09.2018 / PubMed / Full text

DLGAP2

Cross-Species Analyses Identify Dlgap2 as a Regulator of Age-Related Cognitive Decline and Alzheimer's Dementia. / 01.09.2020 / PubMed / Full text

DLL1

MiR-34a Enhances Chondrocyte Apoptosis, Senescence and Facilitates Development of Osteoarthritis by Targeting DLL1 and Regulating PI3K/AKT Pathway. / 2018 / PubMed / Full text

DLL4

Dynamic regulation of NOTCH1 activation and Notch ligand expression in human thymus development. / 13.08.2018 / PubMed / Full text

DMP1

Cx43 overexpression in osteocytes prevents osteocyte apoptosis and preserves cortical bone quality in aging mice. / 07.2018 / PubMed / Full text

DMPK

Expanded CUG Repeats Trigger Disease Phenotype and Expression Changes through the RNAi Machinery in C. elegans. / 19.04.2019 / PubMed / Full text

DNAJB9

DNAJB9 Inhibits p53-Dependent Oncogene-Induced Senescence and Induces Cell Transformation. / 30.04.2020 / PubMed / Full text

DNM1

Increased Degradation Rates in the Components of the Mitochondrial Oxidative Phosphorylation Chain in the Cerebellum of Old Mice. / 2018 / PubMed / Full text

DNM2

Tamoxifen prolongs survival and alleviates symptoms in mice with fatal X-linked myotubular myopathy. / 19.11.2018 / PubMed / Full text

DNMT3L

Transient DNMT3L Expression Reinforces Chromatin Surveillance to Halt Senescence Progression in Mouse Embryonic Fibroblast. / 2020 / PubMed / Full text

DOCK11

[Immunosenescence: The Forefront of Infection and Trophic Control]. / 2020 / PubMed / Full text

DOT1L

Metformin regulates mitochondrial biogenesis and senescence through AMPK mediated H3K79 methylation: Relevance in age-associated vascular dysfunction. / 04.2018 / PubMed / Full text

DPP6

A novel structure associated with aging is augmented in the DPP6-KO mouse brain. / 23.11.2020 / PubMed / Full text

DPT

Influence of season, age and management on scrotal thermal profile in Murrah bulls using scrotal infrared digital thermography. / 12.2017 / PubMed / Full text

DPYSL2

Alcohol drinking exacerbates neural and behavioral pathology in the 3xTg-AD mouse model of Alzheimer's disease. / 2019 / PubMed / Full text

DRAM1

Genome-wide meta-analysis of macronutrient intake of 91,114 European ancestry participants from the cohorts for heart and aging research in genomic epidemiology consortium. / 12.2019 / PubMed / Full text

DRAM2

SIRT6 histone deacetylase functions as a potential oncogene in human melanoma. / 09.2017 / PubMed / Full text

DRD1

Impact of dopamine-related genetic variants on physical activity in old age - a cohort study. / 24.05.2020 / PubMed / Full text

DRD4

ADHD risk genes involved in dopamine signaling and metabolism are associated with reduced estimated life expectancy at young adult follow-up in hyperactive and control children. / 04.2019 / PubMed / Full text

DROSHA

Profiling of m6A RNA modifications identified an age-associated regulation of AGO2 mRNA stability. / 06.2018 / PubMed / Full text

DSC1

HDLs and the pathogenesis of atherosclerosis. / 05.2018 / PubMed / Full text

DSCAM

Age- and speed-dependent modulation of gaits in DSCAM mutant mice. / 01.02.2018 / PubMed / Full text

DSE

Impact of Intensive Lifestyle Intervention on Disability-Free Life Expectancy: The Look AHEAD Study. / 05.2018 / PubMed / Full text

DSPP

Effects of [i]p[/i]-Cresol on Senescence, Survival, Inflammation, and Odontoblast Differentiation in Canine Dental Pulp Stem Cells. / 21.09.2020 / PubMed / Full text

DTL

Targeting DTL induces cell cycle arrest and senescence and suppresses cell growth and colony formation through TPX2 inhibition in human hepatocellular carcinoma cells. / 2018 / PubMed / Full text

DTNBP1

Genetic Biomarkers on Age-Related Cognitive Decline. / 2017 / PubMed / Full text

DUSP1

miR-1468-3p Promotes Aging-Related Cardiac Fibrosis. / 05.06.2020 / PubMed / Full text

DUSP2

Aging Increases Hippocampal DUSP2 by a Membrane Cholesterol Loss-Mediated RTK/p38MAPK Activation Mechanism. / 2019 / PubMed / Full text

DUSP8

MiR-21-5p/dual-specificity phosphatase 8 signalling mediates the anti-inflammatory effect of haem oxygenase-1 in aged intracerebral haemorrhage rats. / 12.2019 / PubMed / Full text

DUT

Simultaneous liquefaction, saccharification, and fermentation of L-lactic acid using aging paddy rice with hull by an isolated thermotolerant Enterococcus faecalis DUT1805. / 09.2020 / PubMed / Full text

DYNC2H1

Role for intraflagellar transport in building a functional transition zone. / 12.2018 / PubMed / Full text

DYRK1A

Altered age-linked regulation of plasma DYRK1A in elderly cognitive complainers (INSIGHT-preAD study) with high brain amyloid load. / 2020 / PubMed / Full text

E2F3

Time-course transcriptome analysis of medullary thymic epithelial cells in the early phase of thymic involution. / 07.2018 / PubMed / Full text

ECM1

Novel role of extracellular matrix protein 1 (ECM1) in cardiac aging and myocardial infarction. / 2019 / PubMed / Full text

ECRG4

ECRG4: a new potential target in precision medicine. / 10.2019 / PubMed / Full text

ECSIT

Longevity-related molecular pathways are subject to midlife "switch" in humans. / 08.2019 / PubMed / Full text

EDEM1

Expression of lipogenic markers is decreased in subcutaneous adipose tissue and adipocytes of older women and is negatively linked to GDF15 expression. / 08.2019 / PubMed / Full text

EDF1

Silencing of FOREVER YOUNG FLOWER Like Genes from Phalaenopsis Orchids Promotes Flower Senescence and Abscission. / 25.11.2020 / PubMed / Full text

EDN1

Dexamethasone downregulates SIRT1 and IL6 and upregulates EDN1 genes in stem cells derived from gingivae via the AGE/RAGE pathway. / 03.2018 / PubMed / Full text

EED

Economic evaluations of eHealth technologies: A systematic review. / 2018 / PubMed / Full text

EFEMP1

A novel age-related venous amyloidosis derived from EGF-containing fibulin-like extracellular matrix protein 1. / 04.2019 / PubMed / Full text

EHF

Extended high frequency hearing and speech perception implications in adults and children. / 11.2020 / PubMed / Full text

EID3

Upregulation of EID3 sensitizes breast cancer cells to ionizing radiation-induced cellular senescence. / 11.2018 / PubMed / Full text

EIF2B1

Mendelian adult-onset leukodystrophy genes in Alzheimer's disease: critical influence of CSF1R and NOTCH3. / 06.2018 / PubMed / Full text

EIF2B2

Mendelian adult-onset leukodystrophy genes in Alzheimer's disease: critical influence of CSF1R and NOTCH3. / 06.2018 / PubMed / Full text

EIF2B3

Mendelian adult-onset leukodystrophy genes in Alzheimer's disease: critical influence of CSF1R and NOTCH3. / 06.2018 / PubMed / Full text

EIF2B4

Mendelian adult-onset leukodystrophy genes in Alzheimer's disease: critical influence of CSF1R and NOTCH3. / 06.2018 / PubMed / Full text

EIF2B5

Mendelian adult-onset leukodystrophy genes in Alzheimer's disease: critical influence of CSF1R and NOTCH3. / 06.2018 / PubMed / Full text

EIF4E

Transcriptomic evidence that insulin signalling pathway regulates the ageing of subterranean termite castes. / 18.05.2020 / PubMed / Full text

ELANE

Both Granulocytic and Non-Granulocytic Blood Cells Are Affected in Patients with Severe Congenital Neutropenia and Their Non-Neutropenic Family Members: An Evaluation of Morphology, Function, and Cell Death / 13.11.2018 / PubMed / Full text

ELF3

High Ambient Temperature Accelerates Leaf Senescence via PHYTOCHROME-INTERACTING FACTOR 4 and 5 in [i]Arabidopsis[/i]. / 31.07.2020 / PubMed / Full text

ELL

Exceptional Longevity and Polygenic Risk for Cardiovascular Health. / 18.03.2019 / PubMed / Full text

ELOVL6

An Adult Drosophila Glioma Model for Studying Pathometabolic Pathways of Gliomagenesis. / 06.2019 / PubMed / Full text

EML6

Cell fate regulation by reticulon-4 in human prostate cancers. / 07.2019 / PubMed / Full text

ENC1

Selective molecular biomarkers to predict biologic behavior in pituitary tumors. / 05.2017 / PubMed / Full text

ENO1

Reduced expression of enolase-1 correlates with high intracellular glucose levels and increased senescence in cisplatin-resistant ovarian cancer cells. / 2020 / PubMed / Full text

ENTPD7

Inhibition of lung cancer cells and Ras/Raf/MEK/ERK signal transduction by ectonucleoside triphosphate phosphohydrolase-7 (ENTPD7). / 23.08.2019 / PubMed / Full text

EPG5

Genome-wide scan of depressive symptomatology in two representative cohorts in the United States and the United Kingdom. / 05.2018 / PubMed / Full text

EPHA1

Whole-Exome Sequencing of an Exceptional Longevity Cohort. / 16.08.2019 / PubMed / Full text

EPHA2

Germ-line and somatic EPHA2 coding variants in lens aging and cataract. / 2017 / PubMed / Full text

ERAP1

Epigenome-wide exploratory study of monozygotic twins suggests differentially methylated regions to associate with hand grip strength. / 10.2019 / PubMed / Full text

ERBB4

Overexpression of ERBB4 rejuvenates aged mesenchymal stem cells and enhances angiogenesis via PI3K/AKT and MAPK/ERK pathways. / 03.2019 / PubMed / Full text

ERCC2

The genetic component of human longevity: New insights from the analysis of pathway-based SNP-SNP interactions. / 06.2018 / PubMed / Full text

ERCC5

Identification of a ERCC5 c.2333T>C (L778P) Variant in Two Tunisian Siblings With Mild Xeroderma Pigmentosum Phenotype. / 2019 / PubMed / Full text

ERCC6

Two Cockayne Syndrome patients with a novel splice site mutation - clinical and metabolic analyses. / 10.2018 / PubMed / Full text

ERCC8

Analysis of somatic mutations identifies signs of selection during in vitro aging of primary dermal fibroblasts. / 12.2019 / PubMed / Full text

ESPL1

Identification and genomic analysis of pedigrees with exceptional longevity identifies candidate rare variants. / 09.2020 / PubMed / Full text

ESR1

Menopause and adipose tissue: miR-19a-3p is sensitive to hormonal replacement. / 05.01.2018 / PubMed / Full text

ESRG

MYC Releases Early Reprogrammed Human Cells from Proliferation Pause via Retinoblastoma Protein Inhibition. / 10.04.2018 / PubMed / Full text

ETV5

miR-19b-3p induces cell proliferation and reduces heterochromatin-mediated senescence through PLZF in goat male germline stem cells. / 06.2018 / PubMed / Full text

ETV6

FOXO1 and ETV6 genes may represent novel regulators of splicing factor expression in cellular senescence. / 01.2019 / PubMed / Full text

EVL

Health Years in Total: A New Health Objective Function for Cost-Effectiveness Analysis. / 01.2020 / PubMed / Full text

EWSR1

EWSR1, a multifunctional protein, regulates cellular function and aging via genetic and epigenetic pathways. / 01.07.2019 / PubMed / Full text

EXD2

EXD2 governs germ stem cell homeostasis and lifespan by promoting mitoribosome integrity and translation. / 02.2018 / PubMed / Full text

EXO1

Polymorphisms of the DNA repair gene EXO1 modulate cognitive aging in old adults in a Taiwanese population. / 06.2019 / PubMed / Full text

EXOC7

PTBP1-Mediated Alternative Splicing Regulates the Inflammatory Secretome and the Pro-tumorigenic Effects of Senescent Cells. / 09.07.2018 / PubMed / Full text

EZR

Proteomic analysis of six- and twelve-month hippocampus and cerebellum in a murine Down syndrome model. / 03.2018 / PubMed / Full text

F10

Hydroalcoholic extract of Spartium junceum L. flowers inhibits growth and melanogenesis in B16-F10 cells by inducing senescence. / 15.07.2018 / PubMed / Full text

F12

Multigenerational effects of carbendazim in Daphnia magna: From a subcellular to a population level. / 02.2019 / PubMed / Full text

FA2H

C. Elegans Fatty Acid Two-Hydroxylase Regulates Intestinal Homeostasis by Affecting Heptadecenoic Acid Production. / 2018 / PubMed / Full text

FABP1

Expression of digestive enzyme and intestinal transporter genes during chronic heat stress in the thermally manipulated broiler chicken. / 01.09.2019 / PubMed / Full text

FADD

Improved age-related deficits in cognitive performance and affective-like behavior following acute, but not repeated, 8-OH-DPAT treatments in rats: regulation of hippocampal FADD. / 11.2018 / PubMed / Full text

FADS1

Aging and FADS1 polymorphisms decrease the biosynthetic capacity of long-chain PUFAs: A human trial using [U- C]linoleic acid. / 09.2019 / PubMed / Full text

FAH

Oxaloacetate decarboxylase FAHD1 - a new regulator of mitochondrial function and senescence. / 01.2019 / PubMed / Full text

FAHD1

Oxaloacetate decarboxylase FAHD1 - a new regulator of mitochondrial function and senescence. / 01.2019 / PubMed / Full text

FAM13A

Trade-offs in aging lung diseases: a review on shared but opposite genetic risk variants in idiopathic pulmonary fibrosis, lung cancer and chronic obstructive pulmonary disease. / 05.2018 / PubMed / Full text

FANCC

Fanconi Anemia complementation group C protein in metabolic disorders. / 21.06.2018 / PubMed / Full text

FAR2

FAR2 is associated with kidney disease in mice and humans. / 01.08.2018 / PubMed / Full text

FASN

Expression of lipogenic markers is decreased in subcutaneous adipose tissue and adipocytes of older women and is negatively linked to GDF15 expression. / 08.2019 / PubMed / Full text

FBN2

Assessment of Human Skin Gene Expression by Different Blends of Plant Extracts with Implications to Periorbital Skin Aging. / 26.10.2018 / PubMed / Full text

FBXO31

The SCF ubiquitin ligase complex mediates degradation of the tumor suppressor FBXO31 and thereby prevents premature cellular senescence. / 19.10.2018 / PubMed / Full text

FBXO46

The SCF ubiquitin ligase complex mediates degradation of the tumor suppressor FBXO31 and thereby prevents premature cellular senescence. / 19.10.2018 / PubMed / Full text

FCER1G

A Microglial Signature Directing Human Aging and Neurodegeneration-Related Gene Networks. / 2019 / PubMed / Full text

FCGR2A

Impact of C-reactive protein on osteo-/chondrogenic transdifferentiation and calcification of vascular smooth muscle cells. / 03.08.2019 / PubMed / Full text

FDPS

Targeting the phospholipase A2 receptor ameliorates premature aging phenotypes. / 12.2018 / PubMed / Full text

FER

Tracking the recognition of static and dynamic facial expressions of emotion across the life span. / 04.09.2018 / PubMed / Full text

FER1L6

Genome-wide association study and annotating candidate gene networks affecting age at first calving in Nellore cattle. / 12.2017 / PubMed / Full text

FEZ1

Disruption to schizophrenia-associated gene Fez1 in the hippocampus of HDAC11 knockout mice. / 19.09.2017 / PubMed / Full text

FGF6

Genome-wide associations and detection of potential candidate genes for direct genetic and maternal genetic effects influencing dairy cattle body weight at different ages. / 06.02.2019 / PubMed / Full text

FGFR2

Oncogenic mutations in histologically normal endometrium: the new normal? / 10.2019 / PubMed / Full text

FKBP5

Epigenetic upregulation of FKBP5 by aging and stress contributes to NF-κB-driven inflammation and cardiovascular risk. / 04.06.2019 / PubMed / Full text

FLT3

Sequential acquisition of mutations in myelodysplastic syndromes. / 2017 / PubMed / Full text

FMO3

Genetic and Nongenetic Factors Associated with Protein Abundance of Flavin-Containing Monooxygenase 3 in Human Liver. / 11.2017 / PubMed / Full text

FMR1

Static and dynamic postural control deficits in aging fragile X mental retardation 1 (FMR1) gene premutation carriers. / 21.01.2019 / PubMed / Full text

FNTA

The Hip Morphology Changes with Ageing in Asian Population. / 2018 / PubMed / Full text

FOSL2

LncRNA GUARDIN suppresses cellular senescence through a LRP130-PGC1α-FOXO4-p21-dependent signaling axis. / 03.04.2020 / PubMed / Full text

FOXC1

Identification of key genes and transcription factors in aging mesenchymal stem cells by DNA microarray data. / 15.04.2019 / PubMed / Full text

FOXD1

MicroRNA-338-5p plays a tumor suppressor role in glioma through inhibition of the MAPK-signaling pathway by binding to FOXD1. / 12.2018 / PubMed / Full text

FOXL2

Human amniotic mesenchymal stem cells improve ovarian function in natural aging through secreting hepatocyte growth factor and epidermal growth factor. / 09.03.2018 / PubMed / Full text

FOXN1

Thymic rejuvenation via FOXN1-reprogrammed embryonic fibroblasts (FREFs) to counteract age-related inflammation. / 17.09.2020 / PubMed / Full text

FOXP2

Identification of the neurotransmitter profile of AmFoxP expressing neurons in the honeybee brain using double-label in situ hybridization. / 06.11.2018 / PubMed / Full text

FOXP4

Identification of the neurotransmitter profile of AmFoxP expressing neurons in the honeybee brain using double-label in situ hybridization. / 06.11.2018 / PubMed / Full text

FRG1

Intergenerational response of steroidogenesis-related genes to maternal malnutrition. / 10.2019 / PubMed / Full text

FRG2

Intergenerational response of steroidogenesis-related genes to maternal malnutrition. / 10.2019 / PubMed / Full text

FSTL1

Blocking the FSTL1-DIP2A Axis Improves Anti-tumor Immunity. / 14.08.2018 / PubMed / Full text

FZD4

MiR-1292 Targets FZD4 to Regulate Senescence and Osteogenic Differentiation of Stem Cells in TE/SJ/Mesenchymal Tissue System via the Wnt/β-catenin Pathway. / 12.2018 / PubMed / Full text

G6PC

Detection of a novel, primate-specific 'kill switch' tumor suppression mechanism that may fundamentally control cancer risk in humans: an unexpected twist in the basic biology of TP53. / 11.2018 / PubMed / Full text

G6PC3

Both Granulocytic and Non-Granulocytic Blood Cells Are Affected in Patients with Severe Congenital Neutropenia and Their Non-Neutropenic Family Members: An Evaluation of Morphology, Function, and Cell Death / 13.11.2018 / PubMed / Full text

GAB2

Age-related gene expression changes, and transcriptome wide association study of physical and cognitive aging traits, in the Lothian Birth Cohort 1936. / 01.12.2017 / PubMed / Full text

GABARAP

Age-dependent loss of adipose Rubicon promotes metabolic disorders via excess autophagy. / 18.08.2020 / PubMed / Full text

GADD45B

Are There Common Mechanisms Between the Hutchinson-Gilford Progeria Syndrome and Natural Aging? / 2019 / PubMed / Full text

GALC

Analysis of age-related changes in psychosine metabolism in the human brain. / 2018 / PubMed / Full text

GATA1

Aging negatively impacts the ability of megakaryocytes to stimulate osteoblast proliferation and bone mass. / 10.2019 / PubMed / Full text

GATA6

GATA Regulation and Function During the Ovarian Life Cycle. / 2018 / PubMed / Full text

GCAT

Impairing L-Threonine Catabolism Promotes Healthspan through Methylglyoxal-Mediated Proteohormesis. / 03.04.2018 / PubMed / Full text

GCK

The Impact of Biomarker Screening and Cascade Genetic Testing on the Cost-Effectiveness of MODY Genetic Testing. / 12.2019 / PubMed / Full text

GCNT2

Human iPSC-derived MSCs (iMSCs) from aged individuals acquire a rejuvenation signature. / 18.03.2019 / PubMed / Full text

GDA

Comparison of the Shear Bond Strength of Metal Orthodontic Brackets Bonded to Long-term Water-aged and Fresh Porcelain and Composite Surfaces. / 03.2019 / PubMed / Full text

GDF5

An embryonic CaVβ1 isoform promotes muscle mass maintenance via GDF5 signaling in adult mouse. / 06.11.2019 / PubMed / Full text

GDF9

Observation of the influences of diosgenin on aging ovarian reserve and function in a mouse model. / 18.10.2017 / PubMed / Full text

GEN1

US acculturation and poor sleep among an intergenerational cohort of adult Latinos in Sacramento, California. / 01.03.2019 / PubMed / Full text

GFRAL

Growth differentiation factor 15 (GDF15): A survival protein with therapeutic potential in metabolic diseases. / 06.2019 / PubMed / Full text

GGCX

Multiple Modes of Vitamin K Actions in Aging-Related Musculoskeletal Disorders. / 11.06.2019 / PubMed / Full text

GHSR

The genetic component of human longevity: New insights from the analysis of pathway-based SNP-SNP interactions. / 06.2018 / PubMed / Full text

GIT1

GIT2-A keystone in ageing and age-related disease. / 05.2018 / PubMed / Full text

GJA8

The impact of GJA8 SNPs on susceptibility to age-related cataract. / 12.2018 / PubMed / Full text

GJC2

Zebrafish brain RNA sequencing reveals that cell adhesion molecules are critical in brain aging. / 10.2020 / PubMed / Full text

GLA

TLR-adjuvanted nanoparticle vaccines differentially influence the quality and longevity of responses to malaria antigen Pfs25. / 17.05.2018 / PubMed / Full text

GLI1

Sonic hedgehog regulation of cavernous nerve regeneration and neurite formation in aged pelvic plexus. / 02.2019 / PubMed / Full text

GLO1

The AGE-RAGE Axis: Implications for Age-Associated Arterial Diseases. / 2017 / PubMed / Full text

GNAQ

GNAQ expression initiated in multipotent neural crest cells drives aggressive melanoma of the central nervous system. / 01.2020 / PubMed / Full text

GNE

Aberrant mitochondrial morphology and function associated with impaired mitophagy and DNM1L-MAPK/ERK signaling are found in aged mutant Parkinsonian LRRK2 mice. / 10.12.2020 / PubMed / Full text

GNG4

Neurotransmitter Pathway Genes in Cognitive Decline During Aging: Evidence for GNG4 and KCNQ2 Genes. / 05.2018 / PubMed / Full text

GNPAT

Plasmalogens Inhibit Endocytosis of Toll-like Receptor 4 to Attenuate the Inflammatory Signal in Microglial Cells. / 05.2019 / PubMed / Full text

GORAB

Examining tissue composition, whole-bone morphology and mechanical behavior of Gorab mice tibiae: A mouse model of premature aging. / 08.12.2017 / PubMed / Full text

GOT1

Low expression of aging-related [[NRXN3]] is associated with Alzheimer disease: A systematic review and meta-analysis. / 07.2018 / PubMed / Full text

GP1BA

Novel molecular mechanisms for the adaptogenic effects of herbal extracts on isolated brain cells using systems biology. / 15.11.2018 / PubMed / Full text

GP6

Novel molecular mechanisms for the adaptogenic effects of herbal extracts on isolated brain cells using systems biology. / 15.11.2018 / PubMed / Full text

GPBAR1

Activation of the bile acid receptor GPBAR1 (TGR5) ameliorates interleukin-1β (IL-1β)- induced chondrocytes senescence. / 10.2018 / PubMed / Full text

GPC1

Decreased expression of GPC1 in human skin keratinocytes and epidermis during ageing. / 15.10.2019 / PubMed / Full text

GPD2

Switching off IMMP2L signaling drives senescence via simultaneous metabolic alteration and blockage of cell death. / 06.2018 / PubMed / Full text

GPR101

Regulation of Gonadotropin-Releasing Hormone-(1-5) Signaling Genes by Estradiol Is Age Dependent. / 2017 / PubMed / Full text

GPR158

RbAp48 Protein Is a Critical Component of GPR158/OCN Signaling and Ameliorates Age-Related Memory Loss. / 23.10.2018 / PubMed / Full text

GPR173

Regulation of Gonadotropin-Releasing Hormone-(1-5) Signaling Genes by Estradiol Is Age Dependent. / 2017 / PubMed / Full text

GPR19

Novel molecular mechanisms for the adaptogenic effects of herbal extracts on isolated brain cells using systems biology. / 15.11.2018 / PubMed / Full text

GPR37

Prosaposin and its receptors are differentially expressed in the salivary glands of male and female rats. / 08.2018 / PubMed / Full text

GPR37L1

Prosaposin and its receptors are differentially expressed in the salivary glands of male and female rats. / 08.2018 / PubMed / Full text

GPR6

Accelerated Epigenetic Aging and Methylation Disruptions Occur in Human Immunodeficiency Virus Infection Prior to Antiretroviral Therapy. / 22.09.2020 / PubMed / Full text

GPX2

RNA Exosome Complex-Mediated Control of Redox Status in Pluripotent Stem Cells. / 10.10.2017 / PubMed / Full text

GPX3

Long noncoding RNA glutathione peroxidase 3-antisense inhibits lens epithelial cell apoptosis by upregulating glutathione peroxidase 3 expression in age-related cataract. / 2019 / PubMed / Full text

GPX7

Metformin alleviates human cellular aging by upregulating the endoplasmic reticulum glutathione peroxidase 7. / 08.2018 / PubMed / Full text

GRB10

De-silencing [i]Grb10[/i] contributes to acute ER stress-induced steatosis in mouse liver. / 05.2018 / PubMed / Full text

GRB2

Fucoidan⁻Fucoxanthin Ameliorated Cardiac Function via IRS1/GRB2/ SOS1, GSK3β/CREB Pathways and Metabolic Pathways in Senescent Mice. / 21.01.2019 / PubMed / Full text

GREM1

GREM1 inhibits osteogenic differentiation, senescence and BMP transcription of adipose-derived stem cells. / 09.03.2020 / PubMed / Full text

GREM2

Increase of gremlin 2 with age in human adipose-derived stromal/stem cells and its inhibitory effect on adipogenesis. / 12.2019 / PubMed / Full text

GRID1

Gene discovery for high-density lipoprotein cholesterol level change over time in prospective family studies. / 03.2020 / PubMed / Full text

GRIN2B

Medial temporal lobe atrophy relates more strongly to sleep-wake rhythm fragmentation than to age or any other known risk. / 04.2019 / PubMed / Full text

GRK4

G protein-coupled receptor kinase 4-induced cellular senescence and its senescence-associated gene expression profiling. / 15.11.2017 / PubMed / Full text

GRK6

Age-dependent effects of dopamine receptor inactivation on cocaine-induced behaviors in male rats: Evidence of dorsal striatal D2 receptor supersensitivity. / 12.2019 / PubMed / Full text

GRM2

Chronological age prediction based on DNA methylation: Massive parallel sequencing and random forest regression. / 11.2017 / PubMed / Full text

GRM3

Profiling gene expression in the human dentate gyrus granule cell layer reveals insights into schizophrenia and its genetic risk. / 04.2020 / PubMed / Full text

GSN

Oral administration of alcalase potato protein hydrolysate-APPH attenuates high fat diet-induced cardiac complications via TGF-β/GSN axis in aging rats. / 01.2019 / PubMed / Full text

GSTA1

Age-associated changes in GSH S-transferase gene/proteins in livers of rats. / 12.2018 / PubMed / Full text

GSTK1

Age-associated changes in GSH S-transferase gene/proteins in livers of rats. / 12.2018 / PubMed / Full text

GSTM2

Small Extracellular Vesicles Have GST Activity and Ameliorate Senescence-Related Tissue Damage. / 07.07.2020 / PubMed / Full text

GSTM3

Age-associated changes in GSH S-transferase gene/proteins in livers of rats. / 12.2018 / PubMed / Full text

GSTO1

Age-associated changes in GSH S-transferase gene/proteins in livers of rats. / 12.2018 / PubMed / Full text

GSTP1

Age-associated changes in GSH S-transferase gene/proteins in livers of rats. / 12.2018 / PubMed / Full text

GSTT1

Age-associated changes in GSH S-transferase gene/proteins in livers of rats. / 12.2018 / PubMed / Full text

GSTT2

Age-associated changes in GSH S-transferase gene/proteins in livers of rats. / 12.2018 / PubMed / Full text

GSTZ1

Age-associated changes in GSH S-transferase gene/proteins in livers of rats. / 12.2018 / PubMed / Full text

GUK1

Characterization of the impact of GMP/GDP synthesis inhibition on replicative lifespan extension in yeast. / 08.2020 / PubMed / Full text

GYS2

In ovo feeding of creatine pyruvate modulates growth performance, energy reserves and mRNA expression levels of gluconeogenesis and glycogenesis enzymes in liver of embryos and neonatal broilers. / 04.2018 / PubMed / Full text

GZMK

Comprehensive Profiling of an Aging Immune System Reveals Clonal GZMK CD8 T Cells as Conserved Hallmark of Inflammaging. / 21.11.2020 / PubMed / Full text

HADHA

Exosomes from hyperglycemia-stimulated vascular endothelial cells contain versican that regulate calcification/senescence in vascular smooth muscle cells. / 2019 / PubMed / Full text

HAMP

A potent tilapia secreted granulin peptide enhances the survival of transgenic zebrafish infected by Vibrio vulnificus via modulation of innate immunity. / 04.2018 / PubMed / Full text

HAP1

The longevity SNP rs2802292 uncovered: HSF1 activates stress-dependent expression of FOXO3 through an intronic enhancer. / 20.06.2018 / PubMed / Full text

HAS2

Age-related changes in cyclic phosphatidic acid-induced hyaluronic acid synthesis in human fibroblasts. / 01.2018 / PubMed / Full text

HAX1

Both Granulocytic and Non-Granulocytic Blood Cells Are Affected in Patients with Severe Congenital Neutropenia and Their Non-Neutropenic Family Members: An Evaluation of Morphology, Function, and Cell Death / 13.11.2018 / PubMed / Full text

HBD

Impact of reproductive aging on the vaginal microbiome and soluble immune mediators in women living with and at-risk for HIV infection. / 2019 / PubMed / Full text

HBM

The effects of dietary fatty acids on bone, hematopoietic marrow and marrow adipose tissue in a murine model of senile osteoporosis. / 25.09.2019 / PubMed / Full text

HCN4

Structural and functional remodeling of the atrioventricular node with aging in rats: The role of hyperpolarization-activated cyclic nucleotide-gated and ryanodine 2 channels. / 05.2018 / PubMed / Full text

HCRT

Age-related central regulation of orexin and NPY in the short-lived African killifish Nothobranchius furzeri. / 15.05.2019 / PubMed / Full text

HDAC10

Middle-aged female rats lack changes in histone H3 acetylation in the anterior hypothalamus observed in young females on the day of a luteinizing hormone surge. / 17.09.2019 / PubMed / Full text

HDAC11

Disruption to schizophrenia-associated gene Fez1 in the hippocampus of HDAC11 knockout mice. / 19.09.2017 / PubMed / Full text

HDAC8

Histone deacetylase 1 expression is inversely correlated with age in the short-lived fish Nothobranchius furzeri. / 09.2018 / PubMed / Full text

HDC

Induced pluripotency and spontaneous reversal of cellular aging in supercentenarian donor cells. / 07.05.2020 / PubMed / Full text

HES1

A Single-Cell Transcriptomic Atlas of Human Skin Aging. / 23.11.2020 / PubMed / Full text

HHLA2

Impaired Cytolytic Activity and Loss of Clonal Neoantigens in Elderly Patients With Lung Adenocarcinoma. / 05.2019 / PubMed / Full text

HIF1A

Hypoxia-inducible transcription factors, HIF1A and HIF2A, increase in aging mucosal tissues. / 07.2018 / PubMed / Full text

HIF3A

Hypoxia-inducible transcription factors, HIF1A and HIF2A, increase in aging mucosal tissues. / 07.2018 / PubMed / Full text

HIRA

Pak2 kinase promotes cellular senescence and organismal aging. / 02.07.2019 / PubMed / Full text

HJV

Hemojuvelin is a novel suppressor for Duchenne muscular dystrophy and age-related muscle wasting. / 06.2019 / PubMed / Full text

HK2

Resveratrol, an Nrf2 activator, ameliorates aging-related progressive renal injury. / 11.01.2018 / PubMed / Full text

HLA-DMA

Epigenome-wide exploratory study of monozygotic twins suggests differentially methylated regions to associate with hand grip strength. / 10.2019 / PubMed / Full text

HLA-DPA1

17th IHIW component "Immunogenetics of Ageing" - New NGS data. / 09.2019 / PubMed / Full text

HLA-DQA1

17th IHIW component "Immunogenetics of Ageing" - New NGS data. / 09.2019 / PubMed / Full text

HLA-DQB1

Identification of new genetic variants of HLA-DQB1 associated with human longevity and lipid homeostasis-a cross-sectional study in a Chinese population. / 10.11.2017 / PubMed / Full text

HLA-DRB1

The pathophysiology of polymyalgia rheumatica, small pieces of a big puzzle. / 11.2020 / PubMed / Full text

HLA-E

Senescent cells evade immune clearance via HLA-E-mediated NK and CD8 T cell inhibition. / 03.06.2019 / PubMed / Full text

HMGA1

Characterization of [i]HMGA1P6[/i] transgenic mouse embryonic fibroblasts. / 09.2020 / PubMed / Full text

HMGCS1

The Age-dependent Elevation of miR-335-3p Leads to Reduced Cholesterol and Impaired Memory in Brain. / 15.10.2018 / PubMed / Full text

HNF4A

Hepatocyte Nuclear Factor-4α P2 Promoter Variants Are Associated With the Risk of Metabolic Syndrome and Testosterone Deficiency in Aging Taiwanese Men. / 11.2018 / PubMed / Full text

HNRNPA0

The transcript expression levels of HNRNPM, HNRNPA0 and AKAP17A splicing factors may be predictively associated with ageing phenotypes in human peripheral blood. / 10.2019 / PubMed / Full text

HNRNPA1

HNRNPA1-mediated 3' UTR length changes of [i]HN1[/i] contributes to cancer- and senescence-associated phenotypes. / 30.06.2019 / PubMed / Full text

HNRNPM

The transcript expression levels of HNRNPM, HNRNPA0 and AKAP17A splicing factors may be predictively associated with ageing phenotypes in human peripheral blood. / 10.2019 / PubMed / Full text

HOXA3

DNA methylation analysis on purified neurons and glia dissects age and Alzheimer's disease-specific changes in the human cortex. / 25.07.2018 / PubMed / Full text

HOXA4

Epigenetic signatures of Werner syndrome occur early in life and are distinct from normal epigenetic aging processes. / 10.2019 / PubMed / Full text

HOXB7

Impact of HOXB7 overexpression on human adipose-derived mesenchymal progenitors. / 19.03.2019 / PubMed / Full text

HOXC4

Chronological age prediction based on DNA methylation: Massive parallel sequencing and random forest regression. / 11.2017 / PubMed / Full text

HOXD8

Single-Cell Transcriptome Analysis Reveals Six Subpopulations Reflecting Distinct Cellular Fates in Senescent Mouse Embryonic Fibroblasts. / 2020 / PubMed / Full text

HPD

Protein-Amino Acid Metabolism Disarrangements: The Hidden Enemy of Chronic Age-Related Conditions. / 22.03.2018 / PubMed / Full text

HPSE

Distribution of heparan sulfate correlated with the expression of heparanase-1 and matrix metalloproteinase-9 in an ovariectomized rats skin. / 07.2020 / PubMed / Full text

HRG

Chronic dietary ginseng extract administration ameliorates antioxidant and cholinergic systems in the brains of aged mice. / 10.2017 / PubMed / Full text

HRH4

Histamime Receptor H4 as a New Therapeutic Target for Age-related Macular Degeneration. / 11.2016 / PubMed

HS2ST1

Whole Genome Analysis of the Red-Crowned Crane Provides Insight into Avian Longevity. / 31.01.2020 / PubMed / Full text

HSD17B14

Bisphenol A induces DSB-ATM-p53 signaling leading to cell cycle arrest, senescence, autophagy, stress response, and estrogen release in human fetal lung fibroblasts. / 04.2018 / PubMed / Full text

HSD17B4

Autonomous Purkinje cell axonal dystrophy causes ataxia in peroxisomal multifunctional protein-2 deficiency. / 09.2018 / PubMed / Full text

HSD3B2

11-Oxygenated C19 Steroids Do Not Decline With Age in Women. / 01.07.2019 / PubMed / Full text

HSP90AA1

SIRT6 histone deacetylase functions as a potential oncogene in human melanoma. / 09.2017 / PubMed / Full text

HSPA13

Genetic associations with age of menopause in familial longevity. / 10.2019 / PubMed / Full text

HSPA1L

Melatonin suppresses senescence-derived mitochondrial dysfunction in mesenchymal stem cells via the HSPA1L-mitophagy pathway. / 03.2020 / PubMed / Full text

HSPA5

Expression of lipogenic markers is decreased in subcutaneous adipose tissue and adipocytes of older women and is negatively linked to GDF15 expression. / 08.2019 / PubMed / Full text

HSPB1

The beneficial effects of 15 units of high-intensity circuit training in women is modified by age, baseline insulin resistance and physical capacity. / 06.2019 / PubMed / Full text

HSPB6

Lifelong Football Training: Effects on Autophagy and Healthy Longevity Promotion. / 2019 / PubMed / Full text

HSPG2

Proteomic profiling of follicle fluids after superstimulation in one-month-old lambs. / 02.2018 / PubMed / Full text

HTRA1

Mendelian adult-onset leukodystrophy genes in Alzheimer's disease: critical influence of CSF1R and NOTCH3. / 06.2018 / PubMed / Full text

HYOU1

Expression of lipogenic markers is decreased in subcutaneous adipose tissue and adipocytes of older women and is negatively linked to GDF15 expression. / 08.2019 / PubMed / Full text

IAPP

Protein aggregates and proteostasis in aging: Amylin and β-cell function. / 01.2019 / PubMed / Full text

ICAM1

An Inhibitor of Activated Blood Coagulation Factor X Shows Anti-Endothelial Senescence and Anti-Atherosclerotic Effects. / 2019 / PubMed / Full text

ICE1

ATBS1-INTERACTING FACTOR 2 negatively regulates dark- and brassinosteroid-induced leaf senescence through interactions with INDUCER OF CBF EXPRESSION 1. / 19.02.2020 / PubMed / Full text

ID2

Epigenome-wide exploratory study of monozygotic twins suggests differentially methylated regions to associate with hand grip strength. / 10.2019 / PubMed / Full text

IFI27

Ultraviolet B irradiation-induced keratinocyte senescence and impaired development of 3D epidermal reconstruct. / 01.06.2021 / PubMed / Full text

IFIH1

Comparative analysis of microbial sensing molecules in mucosal tissues with aging. / 03.2018 / PubMed / Full text

IFIT1

Sirtuin 1-Chromatin-Binding Dynamics Points to a Common Mechanism Regulating Inflammatory Targets in SIV Infection and in the Aging Brain. / 06.2018 / PubMed / Full text

IFITM1

Age-Associated Changes in the Respiratory Epithelial Response to Influenza Infection. / 10.11.2018 / PubMed / Full text

IFITM3

Small Extracellular Vesicles Are Key Regulators of Non-cell Autonomous Intercellular Communication in Senescence via the Interferon Protein IFITM3. / 25.06.2019 / PubMed / Full text

IFNG

Glutathione Peroxidase 3 Delivered by hiPSC-MSCs Ameliorated Hepatic IR Injury via Inhibition of Hepatic Senescence. / 2018 / PubMed / Full text

IFT140

The Role of IFT140 in Osteogenesis of Adult Mice Long Bone. / 08.2019 / PubMed / Full text

IGF2BP3

Avenanthramide A Induces Cellular Senescence via miR-129-3p/Pirh2/p53 Signaling Pathway To Suppress Colon Cancer Growth. / 01.05.2019 / PubMed / Full text

IGF2R

Insulin-like factor-2 receptor rs9456497 G genotype overrepresents in males of average population and its correlation with cardiovascular risks. / 05-06.2018 / PubMed / Full text

IGFBP4

Quantitative iTRAQ-based proteomic analysis of differentially expressed proteins in aging in human and monkey. / 11.10.2019 / PubMed / Full text

IGFBP6

Proteomic profiling of follicle fluids after superstimulation in one-month-old lambs. / 02.2018 / PubMed / Full text

IGFBP7

Reprogramming of human fibroblasts into osteoblasts by insulin-like growth factor-binding protein 7. / 03.2020 / PubMed / Full text

IGHD

Growth Hormone Deficiency: Health and Longevity. / 01.04.2019 / PubMed / Full text

IGSF1

Age-related gene and miRNA expression changes in airways of healthy individuals. / 06.03.2019 / PubMed / Full text

IHH

Indian Hedgehog regulates senescence in bone marrow-derived mesenchymal stem cell through modulation of ROS/mTOR/4EBP1, p70S6K1/2 pathway. / 01.04.2020 / PubMed / Full text

IKBKB

Therapeutic and preventive effects of exercise on cardiometabolic parameters in aging and obese rats. / 02.2019 / PubMed / Full text

IL13

Age-specific changes in the molecular phenotype of patients with moderate-to-severe atopic dermatitis. / 07.2019 / PubMed / Full text

IL15

Moderate physical activity associated with a higher naïve/memory T-cell ratio in healthy old individuals: potential role of IL15. / 27.04.2020 / PubMed / Full text

IL17RA

Chronic disruptions of circadian sleep regulation induce specific proinflammatory responses in the rat colon. / 2017 / PubMed / Full text

IL18

Aging and the Inflammasomes. / 2018 / PubMed / Full text

IL1R2

Lower levels of interleukin-1β gene expression are associated with impaired Langerhans' cell migration in aged human skin. / 01.2018 / PubMed / Full text

IL22

Age-specific changes in the molecular phenotype of patients with moderate-to-severe atopic dermatitis. / 07.2019 / PubMed / Full text

IL2RA

Dynamic demethylation of the IL2RA promoter during in vitro CD4+ T cell activation in association with IL2RA expression. / 2018 / PubMed / Full text

IL4

Deficiency in Protein Tyrosine Phosphatase PTP1B Shortens Lifespan and Leads to Development of Acute Leukemia. / 01.01.2018 / PubMed / Full text

IL6ST

The senescent status of endothelial cells affects proliferation, inflammatory profile and SOX2 expression in bone marrow-derived mesenchymal stem cells. / 06.2019 / PubMed / Full text

IL9

Transcription factor networks in aged naïve CD4 T cells bias lineage differentiation. / 08.2019 / PubMed / Full text

ILDR1

Genome-wide association meta-analysis identifies five novel loci for age-related hearing impairment. / 23.10.2019 / PubMed / Full text

IMMP2L

Switching off IMMP2L signaling drives senescence via simultaneous metabolic alteration and blockage of cell death. / 06.2018 / PubMed / Full text

ING1

Impaired DNA demethylation of C/EBP sites causes premature aging. / 01.06.2018 / PubMed / Full text

INHBA

Proteomic profiling of follicle fluids after superstimulation in one-month-old lambs. / 02.2018 / PubMed / Full text

INHBE

Human iPSC-derived MSCs (iMSCs) from aged individuals acquire a rejuvenation signature. / 18.03.2019 / PubMed / Full text

INPP4B

[Target protein candidates of hypothalamus in aging rats with intervention by Qiongyugao]. / 04.2016 / PubMed / Full text

INPP5A

DNA methylation analysis on purified neurons and glia dissects age and Alzheimer's disease-specific changes in the human cortex. / 25.07.2018 / PubMed / Full text

IP6K1

The Role of the IGF-1 Signaling Cascade in Muscle Protein Synthesis and Anabolic Resistance in Aging Skeletal Muscle. / 2019 / PubMed / Full text

IPMK

Inositol Polyphosphate Multikinase ([i]IPMK[/i]), a Gene Coding for a Potential Moonlighting Protein, Contributes to Human Female Longevity. / 08.02.2019 / PubMed / Full text

IRF1

Sirtuin 1-Chromatin-Binding Dynamics Points to a Common Mechanism Regulating Inflammatory Targets in SIV Infection and in the Aging Brain. / 06.2018 / PubMed / Full text

IRF5

Age-related differences in interferon regulatory factor-4 and -5 signaling in ischemic brains of mice. / 11.2017 / PubMed / Full text

IRGM

SIRT6 histone deacetylase functions as a potential oncogene in human melanoma. / 09.2017 / PubMed / Full text

ISG15

Transcriptome analysis reveals immune-related gene expression changes with age in giant panda ([i]Ailuropoda melanoleuca[/i]) blood. / 14.01.2019 / PubMed / Full text

ITGA2B

Effect of adding B-vitamins to vitamin D and calcium supplementation on CpG methylation of epigenetic aging markers. / 04.2018 / PubMed / Full text

ITGA3

A transcriptomic analysis of serial-cultured, tonsil-derived mesenchymal stem cells reveals decreased integrin α3 protein as a potential biomarker of senescent cells. / 17.08.2020 / PubMed / Full text

ITGA5

Kaempferol alleviates the reduction of developmental competence during aging of porcine oocytes. / 11.2019 / PubMed / Full text

ITGA6

Selective molecular biomarkers to predict biologic behavior in pituitary tumors. / 05.2017 / PubMed / Full text

ITGAM

Comparative Analysis of Gene Expression Patterns for Oral Epithelium-Related Functions with Aging. / 2019 / PubMed / Full text

ITGB1

Switch in Laminin β2 to Laminin β1 Isoforms During Aging Controls Endothelial Cell Functions-Brief Report. / 05.2018 / PubMed / Full text

ITGB2

A Microglial Signature Directing Human Aging and Neurodegeneration-Related Gene Networks. / 2019 / PubMed / Full text

ITGB4

ITGB4 deficiency induces senescence of airway epithelial cells through p53 activation. / 03.2019 / PubMed / Full text

ITK

Does Tetralogy of Fallot affect brain aging? A proof-of-concept study. / 2018 / PubMed / Full text

ITPR2

The nuclear receptor RXRA controls cellular senescence by regulating calcium signaling. / 12.2018 / PubMed / Full text

JAGN1

Both Granulocytic and Non-Granulocytic Blood Cells Are Affected in Patients with Severe Congenital Neutropenia and Their Non-Neutropenic Family Members: An Evaluation of Morphology, Function, and Cell Death / 13.11.2018 / PubMed / Full text

JAK3

Immunologic effects of chronic administration of tofacitinib, a Janus kinase inhibitor, in cynomolgus monkeys and rats - Comparison of juvenile and adult responses. / 04.2018 / PubMed / Full text

JAM3

Selective molecular biomarkers to predict biologic behavior in pituitary tumors. / 05.2017 / PubMed / Full text

JARID2

Proteomics and metabolomics identify molecular mechanisms of aging potentially predisposing for chronic lymphocytic leukemia. / 02.2018 / PubMed / Full text

JDP2

Jun dimerization protein 2 controls hypoxia-induced replicative senescence via both the p16 -pRb and Arf-p53 pathways. / 11.2017 / PubMed / Full text

JUNB

Promotion of cellular senescence by THG-1/TSC22D4 knockout through activation of JUNB. / 19.02.2020 / PubMed / Full text

KAT6B

Aging-associated decrease in the histone acetyltransferase KAT6B is linked to altered hematopoietic stem cell differentiation. / 02.2020 / PubMed / Full text

KCNAB3

Tracking age-correlated DNA methylation markers in the young. / 09.2018 / PubMed / Full text

KCNB1

Oxidation of KCNB1 potassium channels in the murine brain during aging is associated with cognitive impairment. / 14.05.2019 / PubMed / Full text

KCNC3

DNA methylation levels in candidate genes associated with chronological age in mammals are not conserved in a long-lived seabird. / 2017 / PubMed / Full text

KCNE4

Kcne4 deletion sex-specifically predisposes to cardiac arrhythmia via testosterone-dependent impairment of RISK/SAFE pathway induction in aged mice. / 29.05.2018 / PubMed / Full text

KCNK2

Brain age prediction using deep learning uncovers associated sequence variants. / 27.11.2019 / PubMed / Full text

KCNQ2

Neurotransmitter Pathway Genes in Cognitive Decline During Aging: Evidence for GNG4 and KCNQ2 Genes. / 05.2018 / PubMed / Full text

KCNQ4

Guanylyl Cyclase A/cGMP Signaling Slows Hidden, Age- and Acoustic Trauma-Induced Hearing Loss. / 2020 / PubMed / Full text

KCTD12

The association between poverty and gene expression within peripheral blood mononuclear cells in a diverse Baltimore City cohort. / 2020 / PubMed / Full text

KDM2A

SIRT6 mono-ADP ribosylates KDM2A to locally increase H3K36me2 at DNA damage sites to inhibit transcription and promote repair. / 25.06.2020 / PubMed / Full text

KDM2B

Identification of Structural Elements of the Lysine Specific Demethylase 2B CxxC Domain Associated with Replicative Senescence Bypass in Primary Mouse Cells. / 06.2020 / PubMed / Full text

KDM3A

KDM3A and KDM4C Regulate Mesenchymal Stromal Cell Senescence and Bone Aging via Condensin-mediated Heterochromatin Reorganization. / 22.11.2019 / PubMed / Full text

KDM4A

Structure-Based Discovery of a Selective KDM5A Inhibitor that Exhibits Anti-Cancer Activity via Inducing Cell Cycle Arrest and Senescence in Breast Cancer Cell Lines. / 15.01.2019 / PubMed / Full text

KDM5A

Structure-Based Discovery of a Selective KDM5A Inhibitor that Exhibits Anti-Cancer Activity via Inducing Cell Cycle Arrest and Senescence in Breast Cancer Cell Lines. / 15.01.2019 / PubMed / Full text

KDM6B

Histone demethylase KDM6B regulates 1,25-dihydroxyvitamin D3-induced senescence in glioma cells. / 08.2019 / PubMed / Full text

KIF1A

SerThr-PhosphoProteome of Brain from Aged PINK1-KO+A53T-SNCA Mice Reveals pT1928-MAP1B and pS3781-ANK2 Deficits, as Hub between Autophagy and Synapse Changes. / 04.07.2019 / PubMed / Full text

KIF1B

BDNF trafficking and signaling impairment during early neurodegeneration is prevented by moderate physical activity. / 12.2016 / PubMed / Full text

KIFC3

Defective recruitment of motor proteins to autophagic compartments contributes to autophagic failure in aging. / 08.2018 / PubMed / Full text

KLB

Infants Uniquely Express High Levels of RBM3 and Other Cold-Adaptive Neuroprotectant Proteins in the Human Brain. / 2018 / PubMed / Full text

KLF1

Mutant KLF1 in Adult Anemic Nan Mice Leads to Profound Transcriptome Changes and Disordered Erythropoiesis. / 24.08.2018 / PubMed / Full text

KLF2

KLF2 induces the senescence of pancreatic cancer cells by cooperating with FOXO4 to upregulate p21. / 01.03.2020 / PubMed / Full text

KLF5

EGR1 promotes the cartilage degeneration and hypertrophy by activating the Krüppel-like factor 5 and β-catenin signaling. / 01.09.2019 / PubMed / Full text

KLF6

Krüppel-Like Factor 6 Is Required for Oxidative and Oncogene-Induced Cellular Senescence. / 2019 / PubMed / Full text

KLHL22

KLHL22 activates amino-acid-dependent mTORC1 signalling to promote tumorigenesis and ageing. / 05.2018 / PubMed / Full text

KPNA2

Karyopherin Alpha 2-Expressing Pancreatic Duct Glands and Intra-Islet Ducts in Aged Diabetic C414A-Mutant-CRY1 Transgenic Mice. / 2019 / PubMed / Full text

KRT15

Extracellular proteoglycan decorin maintains human hair follicle stem cells. / 12.2018 / PubMed / Full text

KRT18

Towards frailty biomarkers: Candidates from genes and pathways regulated in aging and age-related diseases. / 11.2018 / PubMed / Full text

KRT19

Characterization of Krt19 allele for targeting the nucleus pulposus cells in the postnatal mouse intervertebral disc. / 01.2020 / PubMed / Full text

KY

Combination of acupuncture and Chinese herbal formula for elderly adults with mild cognitive impairment: protocol for a randomized controlled trial. / 11.02.2019 / PubMed / Full text

LAG3

T Cell Transcriptional Profiling and Immunophenotyping Uncover LAG3 as a Potential Significant Target of Immune Modulation in Multiple Myeloma. / 01.2020 / PubMed / Full text

LAGE3

Novel homozygous OSGEP gene pathogenic variants in two unrelated patients with Galloway-Mowat syndrome: case report and review of the literature. / 11.04.2019 / PubMed / Full text

LAMA2

[Alu insertion-deletion polymorphism of COL13A1 and LAMA2 genes: The analysis of association with longevity]. / 10.2016 / PubMed

LAMA5

The correlation of copy number variations with longevity in a genome-wide association study of Han Chinese. / 05.06.2018 / PubMed / Full text

LAT

Is the combined auriculotherapy approach superior to magneto-auriculotherapy alone in aging males with lower urinary tract symptoms? A randomized controlled trial. / 16.01.2019 / PubMed / Full text

LCN2

Anthropometric and glucometabolic changes in an aged mouse model of lipocalin-2 overexpression. / 01.2019 / PubMed / Full text

LDB2

Chronological age prediction based on DNA methylation: Massive parallel sequencing and random forest regression. / 11.2017 / PubMed / Full text

LDLR

Inactivation of the E3 Ubiquitin Ligase IDOL Attenuates Diet-Induced Obesity and Metabolic Dysfunction in Mice. / 08.2018 / PubMed / Full text

LEF1

LncRNA H19 targets miR-22 to modulate H O -induced deregulation in nucleus pulposus cell senescence, proliferation, and ECM synthesis through Wnt signaling. / 06.2018 / PubMed / Full text

LGALS3

Tissue Taurine Depletion Induces Profibrotic Pattern of Gene Expression and Causes Aging-Related Cardiac Fibrosis in Heart in Mice. / 2018 / PubMed / Full text

LGI1

Antibody-associated CNS syndromes without signs of inflammation in the elderly. / 03.10.2017 / PubMed / Full text

LGR6

Effect of defensins-containing eye cream on periocular rhytids and skin quality. / 08.2020 / PubMed / Full text

LHCGR

Comparative Study of the Steroidogenic Effects of Human Chorionic Gonadotropin and Thieno[2,3-D]pyrimidine-Based Allosteric Agonist of Luteinizing Hormone Receptor in Young Adult, Aging and Diabetic Male Rats. / 11.10.2020 / PubMed / Full text

LIFR

Efficacy of leukemia inhibitory factor as a therapeutic for permanent large vessel stroke differs among aged male and female rats. / 15.03.2019 / PubMed / Full text

LIN28B

Genetic variations, reproductive aging, and breast cancer risk in African American and European American women: The Women's Circle of Health Study. / 2017 / PubMed / Full text

LIPA

Influence of Habitual Physical Behavior - Sleeping, Sedentarism, Physical Activity - On Bone Health in Community-Dwelling Older People. / 2019 / PubMed / Full text

LMX1A

Phenotypic Reprogramming of Striatal Neurons into Dopaminergic Neuron-like Cells in the Adult Mouse Brain. / 13.11.2018 / PubMed / Full text

LOXL1

A blackberry-dill extract combination synergistically increases skin elasticity. / 10.2020 / PubMed / Full text

LPAR3

Upregulated microRNA-15b alleviates ovarian cancer through inhitbition of the PI3K/Akt pathway by targeting LPAR3. / 12.2019 / PubMed / Full text

LRP1

Drug Targeting of Plasminogen Activator Inhibitor-1 Inhibits Metabolic Dysfunction and Atherosclerosis in a Murine Model of Metabolic Syndrome. / 06.2020 / PubMed / Full text

LRP2

Single-Cell Transcriptomics Characterizes Cell Types in the Subventricular Zone and Uncovers Molecular Defects Impairing Adult Neurogenesis. / 27.11.2018 / PubMed / Full text

LRP6

Low-density lipoprotein receptor-related protein 6-mediated signaling pathways and associated cardiovascular diseases: diagnostic and therapeutic opportunities. / 04.2020 / PubMed / Full text

LRP8

SFRS11 Loss Leads to Aging-Associated Cognitive Decline by Modulating LRP8 and ApoE. / 02.07.2019 / PubMed / Full text

LRRC34

The polygenic nature of telomere length and the anti-ageing properties of lithium. / 03.2019 / PubMed / Full text

LRRC8B

DNA methylation analysis on purified neurons and glia dissects age and Alzheimer's disease-specific changes in the human cortex. / 25.07.2018 / PubMed / Full text

LRRK1

Age-Dependent Dopaminergic Neurodegeneration and Impairment of the Autophagy-Lysosomal Pathway in LRRK-Deficient Mice. / 15.11.2017 / PubMed / Full text

LTF

Uncovering genetic mechanisms of kidney aging through transcriptomics, genomics, and epigenomics. / 03.2019 / PubMed / Full text

LY6D

LY6D-induced macropinocytosis as a survival mechanism of senescent cells. / 09.11.2020 / PubMed / Full text

LY86

Identification of age- and gender-associated long noncoding RNAs in the human brain with Alzheimer's disease. / 09.2019 / PubMed / Full text

LYG1

Uncovering genetic mechanisms of kidney aging through transcriptomics, genomics, and epigenomics. / 03.2019 / PubMed / Full text

LYST

Whole-Exome Sequencing of an Exceptional Longevity Cohort. / 16.08.2019 / PubMed / Full text

MAF

Biocatalytic Degradation Efficiency of Postconsumer Polyethylene Terephthalate Packaging Determined by Their Polymer Microstructures. / 17.07.2019 / PubMed / Full text

MAF1

Beyond regulation of pol III: Role of MAF1 in growth, metabolism, aging and cancer. / 04.2018 / PubMed / Full text

MAFB

Age-dependent skeletal muscle transcriptome response to bed rest-induced atrophy. / 01.04.2019 / PubMed / Full text

MAL

Daylight photodynamic therapy versus cryosurgery for the treatment and prophylaxis of actinic keratoses of the face - protocol of a multicenter, prospective, randomized, controlled, two-armed study. / 25.10.2017 / PubMed / Full text

MAOA

Inflammasome-driven catecholamine catabolism in macrophages blunts lipolysis during ageing. / 05.10.2017 / PubMed / Full text

MAP1A

SerThr-PhosphoProteome of Brain from Aged PINK1-KO+A53T-SNCA Mice Reveals pT1928-MAP1B and pS3781-ANK2 Deficits, as Hub between Autophagy and Synapse Changes. / 04.07.2019 / PubMed / Full text

MAP1B

SerThr-PhosphoProteome of Brain from Aged PINK1-KO+A53T-SNCA Mice Reveals pT1928-MAP1B and pS3781-ANK2 Deficits, as Hub between Autophagy and Synapse Changes. / 04.07.2019 / PubMed / Full text

MAP2K3

Associations of [i]MAP2K3[/i] Gene Variants With Superior Memory in SuperAgers. / 2018 / PubMed / Full text

MAP3K5

Analysis of Polymorphisms in 59 Potential Candidate Genes for Association With Human Longevity. / 08.10.2018 / PubMed / Full text

MAP4K3

MAP4K3/GLK in autoimmune disease, cancer and aging. / 22.10.2019 / PubMed / Full text

MAPK10

Novel molecular mechanisms for the adaptogenic effects of herbal extracts on isolated brain cells using systems biology. / 15.11.2018 / PubMed / Full text

MAPK11

lncRNA ENSMUST00000134285 Increases MAPK11 Activity, Regulating Aging-Related Myocardial Apoptosis. / 09.07.2018 / PubMed / Full text

MAPK13

Novel molecular mechanisms for the adaptogenic effects of herbal extracts on isolated brain cells using systems biology. / 15.11.2018 / PubMed / Full text

MAPK8

Therapeutic and preventive effects of exercise on cardiometabolic parameters in aging and obese rats. / 02.2019 / PubMed / Full text

MARCKS

Ser46-Phosphorylated MARCKS Is a Marker of Neurite Degeneration at the Pre-aggregation Stage in PD/DLB Pathology. / 07-08.2018 / PubMed / Full text

MARCKSL1

MARCKSL1 Regulates Spine Formation in the Amygdala and Controls the Hypothalamic-Pituitary-Adrenal Axis and Anxiety-Like Behaviors. / 04.2018 / PubMed / Full text

MARK1

SerThr-PhosphoProteome of Brain from Aged PINK1-KO+A53T-SNCA Mice Reveals pT1928-MAP1B and pS3781-ANK2 Deficits, as Hub between Autophagy and Synapse Changes. / 04.07.2019 / PubMed / Full text

MAS1

AVE0991, a nonpeptide analogue of Ang-(1-7), attenuates aging-related neuroinflammation. / 17.04.2018 / PubMed / Full text

MATN3

Mice Lacking the Matrilin Family of Extracellular Matrix Proteins Develop Mild Skeletal Abnormalities and Are Susceptible to Age-Associated Osteoarthritis. / 19.01.2020 / PubMed / Full text

MAVS

Spontaneous activation of a MAVS-dependent antiviral signaling pathway determines high basal interferon-β expression in cardiac myocytes. / 10.2017 / PubMed / Full text

MAX

Validation of the MedUseQ: A Self-Administered Screener for Older Adults to Assess Medication Use Problems. / 10.2019 / PubMed / Full text

MBD2

Age-related Changes in the Global DNA Methylation Profile of Oligodendrocyte Progenitor Cells Derived from Rat Spinal Cords. / 02.2019 / PubMed / Full text

MC1R

In vitro behavior and UV response of melanocytes derived from carriers of [[CDKN2A]] mutations and MC1R variants. / 03.2019 / PubMed / Full text

MCAT

Small molecules as therapeutic drugs for Alzheimer's disease. / 04.2019 / PubMed / Full text

MCF2L

DNA methylation analysis on purified neurons and glia dissects age and Alzheimer's disease-specific changes in the human cortex. / 25.07.2018 / PubMed / Full text

MCM3

Changes in MCM2-7 proteins at senescence. / 27.07.2019 / PubMed / Full text

MCM4

Changes in MCM2-7 proteins at senescence. / 27.07.2019 / PubMed / Full text

MCM5

Changes in MCM2-7 proteins at senescence. / 27.07.2019 / PubMed / Full text

MCM6

Changes in MCM2-7 proteins at senescence. / 27.07.2019 / PubMed / Full text

MCM8

Genetic variations, reproductive aging, and breast cancer risk in African American and European American women: The Women's Circle of Health Study. / 2017 / PubMed / Full text

MCM9

MCM8- and MCM9 Deficiencies Cause Lifelong Increased Hematopoietic DNA Damage Driving p53-Dependent Myeloid Tumors. / 10.09.2019 / PubMed / Full text

MCUR1

Cytosolic and mitochondrial Ca concentrations in primary hepatocytes change with ageing and in consequence of an mtDNA mutation. / 09.2019 / PubMed / Full text

MDK

A large-scale CRISPR screen and identification of essential genes in cellular senescence bypass. / 20.06.2019 / PubMed / Full text

MDN1

Whole-Exome Sequencing of an Exceptional Longevity Cohort. / 16.08.2019 / PubMed / Full text

ME1

NADP-MALIC ENZYME 1 Affects Germination after Seed Storage in Arabidopsis thaliana. / 01.02.2019 / PubMed / Full text

MECOM

Clinical and genetic risk factors for decreased bone mineral density in Japanese patients with inflammatory bowel disease. / 11.2018 / PubMed / Full text

MED25

The [i]HAC1[/i] histone acetyltransferase promotes leaf senescence and regulates the expression of [i]ERF022[/i]. / 08.2019 / PubMed / Full text

MEFV

The grandfather's fever. / 02.2020 / PubMed / Full text

MEOX2

Reduced expression of microRNA-130a promotes endothelial cell senescence and age-dependent impairment of neovascularization. / 26.05.2020 / PubMed / Full text

MERTK

Novel molecular mechanisms for the adaptogenic effects of herbal extracts on isolated brain cells using systems biology. / 15.11.2018 / PubMed / Full text

MEST

Improving specific autobiographical memory in older adults: impacts on mood, social problem solving, and functional limitations. / 09.2018 / PubMed / Full text

MFN1

Increased Degradation Rates in the Components of the Mitochondrial Oxidative Phosphorylation Chain in the Cerebellum of Old Mice. / 2018 / PubMed / Full text

MFSD2A

Decreased Blood Level of MFSD2a as a Potential Biomarker of Alzheimer's Disease. / 20.12.2019 / PubMed / Full text

MGRN1

Chronic and age-dependent effects of the spongiform neurodegeneration-associated MGRN1 E3 ubiquitin ligase on mitochondrial homeostasis. / 06.2019 / PubMed / Full text

MIB1

Immunohistochemical detection of senescence markers in human sarcomas. / 02.2020 / PubMed / Full text

MICA

Derivation and Validation of a Geriatric-Sensitive Perioperative Cardiac Risk Index. / 16.11.2017 / PubMed / Full text

MICB

Genetic associations with age of menopause in familial longevity. / 10.2019 / PubMed / Full text

MICU1

Cytosolic and mitochondrial Ca concentrations in primary hepatocytes change with ageing and in consequence of an mtDNA mutation. / 09.2019 / PubMed / Full text

MLH3

Age-Dependent Alterations in Meiotic Recombination Cause Chromosome Segregation Errors in Spermatocytes. / 19.10.2017 / PubMed / Full text

MMP12

Macrophage-Restricted Shp2 Tyrosine Phosphatase Acts as a Rheostat for MMP12 through TGF-β Activation in the Prevention of Age-Related Emphysema in Mice. / 01.10.2017 / PubMed / Full text

MMP14

Overexpression of microRNA-1470 promotes proliferation and migration, and inhibits senescence of esophageal squamous carcinoma cells. / 12.2017 / PubMed / Full text

MMP7

Retinoic acid promotes in vitro follicle activation in the cat ovary by regulating expression of matrix metalloproteinase 9. / 2018 / PubMed / Full text

MORF4L1

A large-scale CRISPR screen and identification of essential genes in cellular senescence bypass. / 20.06.2019 / PubMed / Full text

MPHOSPH6

Genome-wide Association Analysis in Humans Links Nucleotide Metabolism to Leukocyte Telomere Length. / 05.03.2020 / PubMed / Full text

MPL

Molecular Pathogenesis of Myeloproliferative Neoplasms: Influence of Age and Gender. / 10.2017 / PubMed / Full text

MPST

Methionine restriction leads to hyperhomocysteinemia and alters hepatic H S production capacity in Fischer-344 rats. / 12.2018 / PubMed / Full text

MR1

Human blood MAIT cell subsets defined using MR1 tetramers. / 05.2018 / PubMed / Full text

MRO

[Effects of different intensities exercise combined with resveratrol on RBP4 in aged obese rats]. / 08.05.2017 / PubMed / Full text

MRPS5

Mutant MRPS5 affects mitoribosomal accuracy and confers stress-related behavioral alterations. / 11.2018 / PubMed / Full text

MRTFA

Endothelial progerin expression causes cardiovascular pathology through an impaired mechanoresponse. / 01.02.2019 / PubMed / Full text

MS4A1

Age-related but not longevity-related genes are found by weighted gene co-expression network analysis in the peripheral blood cells of humans. / 19.01.2019 / PubMed / Full text

MS4A4E

Recent studies on cellular and molecular mechanisms in Alzheimer's disease: focus on epigenetic factors and histone deacetylase. / 28.03.2018 / PubMed / Full text

MS4A6A

Recent studies on cellular and molecular mechanisms in Alzheimer's disease: focus on epigenetic factors and histone deacetylase. / 28.03.2018 / PubMed / Full text

MSH2

RNA-Seq analysis of differentially expressed genes relevant to mismatch repair in aging hematopoietic stem-progenitor cells. / 25.02.2019 / PubMed / Full text

MSH3

RNA-Seq analysis of differentially expressed genes relevant to mismatch repair in aging hematopoietic stem-progenitor cells. / 25.02.2019 / PubMed / Full text

MSH6

RNA-Seq analysis of differentially expressed genes relevant to mismatch repair in aging hematopoietic stem-progenitor cells. / 25.02.2019 / PubMed / Full text

MSRA

Temporal pattern of neuronal insulin release during Caenorhabditis elegans aging: Role of redox homeostasis. / 02.2019 / PubMed / Full text

MST1

[Expression relationship of Hippo signaling molecules and ovarian germline stem cell markers in the ovarian aging process of women and mice]. / 25.06.2019 / PubMed

MTRR

One-carbon metabolism gene polymorphisms are associated with cognitive trajectory among African-American adults. / 12.2019 / PubMed / Full text

MUC5AC

InflammAging at Ocular Surface: Clinical and Biomolecular Analyses in Healthy Volunteers. / 01.04.2019 / PubMed / Full text

MUC7

Reduced Salivary Mucin Binding and Glycosylation in Older Adults Influences Taste in an In Vitro Cell Model. / 24.09.2019 / PubMed / Full text

MUL1

Effects of MUL1 and PARKIN on the circadian clock, brain and behaviour in Drosophila Parkinson's disease models. / 28.05.2019 / PubMed / Full text

MUS81

Mechanistic link between DNA damage sensing, repairing and signaling factors and immune signaling. / 2019 / PubMed / Full text

MX1

Age-Associated Changes in the Respiratory Epithelial Response to Influenza Infection. / 10.11.2018 / PubMed / Full text

MYCN

Silencing of AURKA augments the antitumor efficacy of the AURKA inhibitor MLN8237 on neuroblastoma cells. / 2020 / PubMed / Full text

MYCNOS

Insights into the Function of Long Noncoding RNAs in Sepsis Revealed by Gene Co-Expression Network Analysis. / 26.01.2017 / PubMed / Full text

MYH10

Epigenome-wide exploratory study of monozygotic twins suggests differentially methylated regions to associate with hand grip strength. / 10.2019 / PubMed / Full text

MYLPF

Explaining meat quality of bulls and steers by differential proteome and phosphoproteome analysis of skeletal muscle. / 15.05.2019 / PubMed / Full text

MYO1F

A Microglial Signature Directing Human Aging and Neurodegeneration-Related Gene Networks. / 2019 / PubMed / Full text

MYOC

Binding of a glaucoma-associated myocilin variant to the αB-crystallin chaperone impedes protein clearance in trabecular meshwork cells. / 28.12.2018 / PubMed / Full text

MYOF

Genetics of Human Longevity From Incomplete Data: New Findings From the Long Life Family Study. / 08.10.2018 / PubMed / Full text

MYSM1

MYSM1 Suppresses Cellular Senescence and the Aging Process to Prolong Lifespan. / 11.2020 / PubMed / Full text

MYT1

ESC-sEVs Rejuvenate Aging Hippocampal NSCs by Transferring SMADs to Regulate the MYT1-Egln3-Sirt1 Axis. / 01.10.2020 / PubMed / Full text

NACA

Age and Sex Are Strongly Correlated to the Rate and Type of Mountain Injuries Requiring Search and Rescue Missions. / 12.2019 / PubMed / Full text

NAIP

Protective effect of xanthohumol against age-related brain damage. / 11.2017 / PubMed / Full text

NBN

G protein-coupled receptor kinase 4-induced cellular senescence and its senescence-associated gene expression profiling. / 15.11.2017 / PubMed / Full text

NBR1

Nrf2 mediates the expression of BAG3 and autophagy cargo adaptor proteins and tau clearance in an age-dependent manner. / 03.2018 / PubMed / Full text

NCK2

Genetic associations with age of menopause in familial longevity. / 10.2019 / PubMed / Full text

NCOR2

DNA methylation analysis on purified neurons and glia dissects age and Alzheimer's disease-specific changes in the human cortex. / 25.07.2018 / PubMed / Full text

NDN

The Changing Landscape of Naive T Cell Receptor Repertoire With Human Aging. / 2018 / PubMed / Full text

NDRG1

Cx43 phosphorylation-mediated effects on ERK and Akt protect against ischemia reperfusion injury and alter the stability of the stress-inducible protein NDRG1. / 02.08.2019 / PubMed / Full text

NDRG2

NDRG2 Expression Correlates with Neurofibrillary Tangles and Microglial Pathology in the Ageing Brain. / 04.01.2020 / PubMed / Full text

NDUFAB1

Proteomics and metabolomics identify molecular mechanisms of aging potentially predisposing for chronic lymphocytic leukemia. / 02.2018 / PubMed / Full text

NDUFS1

Mapping the protein phosphorylation sites in human mitochondrial complex I (NADH: Ubiquinone oxidoreductase): A bioinformatics study with implications for brain aging and neurodegeneration. / 01.2019 / PubMed / Full text

NDUFS3

Elucidation of the mechanism of changes in the antioxidant function with the aging in the liver of the senescence-accelerated mouse P10 (SAMP10). / 06.2018 / PubMed / Full text

NDUFS8

Mitochondrial Complex I Mutations Predispose Drosophila to Isoflurane Neurotoxicity. / 01.10.2020 / PubMed / Full text

NDUFV2

Low expression of aging-related [[NRXN3]] is associated with Alzheimer disease: A systematic review and meta-analysis. / 07.2018 / PubMed / Full text

NEFM

Changes in mechanoreceptors in rabbits' anterior cruciate ligaments with age. / 06.2019 / PubMed / Full text

NEIL1

NEIL1 stimulates neurogenesis and suppresses neuroinflammation after stress. / 09.2019 / PubMed / Full text

NEIL3

Age-Related Oxidative Changes in Primary Porcine Fibroblasts Expressing Mutated Huntingtin. / 2019 / PubMed / Full text

NEK2

Upregulation of FOXM1 leads to diminished drug sensitivity in myeloma. / 21.11.2018 / PubMed / Full text

NEO1

Neogenin-1 distinguishes between myeloid-biased and balanced [i]Hoxb5[/i] mouse long-term hematopoietic stem cells. / 10.12.2019 / PubMed / Full text

NFATC1

Age-dependent human β cell proliferation induced by glucagon-like peptide 1 and calcineurin signaling. / 02.10.2017 / PubMed / Full text

NFKB1

NFKB1 gene single-nucleotide polymorphisms: implications for graft-versus-host disease in allogeneic hematopoietic stem cell transplantation. / 03.2020 / PubMed / Full text

NGFR

Evidence for changing nerve growth factor signalling mechanisms during development, maturation and ageing in the rat molar pulp. / 02.2019 / PubMed / Full text

NKAP

NKAP Regulates Senescence and Cell Death Pathways in Hematopoietic Progenitors. / 2019 / PubMed / Full text

NKIRAS2

Chronological age prediction based on DNA methylation: Massive parallel sequencing and random forest regression. / 11.2017 / PubMed / Full text

NKX2-5

Isolation, Characterization, and Differentiation of Cardiac Stem Cells from the Adult Mouse Heart. / 07.01.2019 / PubMed / Full text

NKX6-1

The dynamic methylome of islets in health and disease. / 09.2019 / PubMed / Full text

NLRC5

Methylation of the genes ROD1, NLRC5, and HKR1 is associated with aging in Hainan centenarians. / 02.02.2018 / PubMed / Full text

NLRP1

NADPH oxidase 2-mediated NLRP1 inflammasome activation involves in neuronal senescence in hippocampal neurons in vitro. / 04.2019 / PubMed / Full text

NLRP12

Persistent DNA damage-induced NLRP12 improves hematopoietic stem cell function. / 21.05.2020 / PubMed / Full text

NLRP6

LRP6 targeting suppresses gastric tumorigenesis via P14 -Mdm2-P53-dependent cellular senescence. / 19.12.2017 / PubMed / Full text

NLRX1

NOD-like receptor X1 functions as a tumor suppressor by inhibiting epithelial-mesenchymal transition and inducing aging in hepatocellular carcinoma cells. / 26.02.2018 / PubMed / Full text

NMI

Age-Dependent Control of Shoulder Muscles During a Reach-and-Lift Task. / 10.12.2019 / PubMed / Full text

NMRK2

Aged Nicotinamide Riboside Kinase 2 Deficient Mice Present an Altered Response to Endurance Exercise Training. / 2018 / PubMed / Full text

NMS

Uncontrolled Diabetes as an Associated Factor with Dynapenia in Adults Aged 50 Years or Older: Sex Differences. / 22.05.2020 / PubMed / Full text

NMUR1

[Medicinal Chemistry Focused on Mid-sized Peptides Derived from Biomolecules]. / 2019 / PubMed / Full text

NOA1

The dependence of leaf senescence on the balance between 1-aminocyclopropane-1-carboxylate acid synthase 1 (ACS1)-catalysed ACC generation and nitric oxide-associated 1 (NOS1)-dependent NO accumulation in Arabidopsis. / 07.2019 / PubMed / Full text

NOBOX

Observation of the influences of diosgenin on aging ovarian reserve and function in a mouse model. / 18.10.2017 / PubMed / Full text

NOL12

NOL12 Repression Induces Nucleolar Stress-Driven Cellular Senescence and Is Associated with Normative Aging. / 15.06.2019 / PubMed / Full text

NOTCH4

Age-dependent autophagy induction after injury promotes axon regeneration by limiting NOTCH. / 11.2020 / PubMed / Full text

NPAS2

Is the aging human ovary still ticking?: Expression of clock-genes in luteinized granulosa cells of young and older women. / 21.11.2018 / PubMed / Full text

NPBWR1

Genome-wide association study and annotating candidate gene networks affecting age at first calving in Nellore cattle. / 12.2017 / PubMed / Full text

NPC2

Attenuation of the Niemann-Pick type C2 disease phenotype by intracisternal administration of an AAVrh.10 vector expressing Npc2. / 08.2018 / PubMed / Full text

NPM1

Flow cytometric identification and cell-line establishment of macrophages in naked mole-rats. / 29.11.2019 / PubMed / Full text

NPRL2

KLHL22 activates amino-acid-dependent mTORC1 signalling to promote tumorigenesis and ageing. / 05.2018 / PubMed / Full text

NPRL3

KLHL22 activates amino-acid-dependent mTORC1 signalling to promote tumorigenesis and ageing. / 05.2018 / PubMed / Full text

NPW

Novel information processing at work across time is associated with cognitive change in later life: A 14-year longitudinal study. / 09.2020 / PubMed / Full text

NR3C1

Glucocorticoid receptor (NR3C1) gene polymorphisms are associated with age and blood parameters in Polish Caucasian nonagenarians and centenarians. / 02.2019 / PubMed / Full text

NRARP

Low dose Emodin induces tumor senescence for boosting breast cancer chemotherapy via silencing NRARP. / 10.11.2018 / PubMed / Full text

NRL

Development of a cyclophosphamide stress test to predict resilience to aging in mice. / 12.2020 / PubMed / Full text

NRM

Association between Clonal Hematopoiesis and Late Nonrelapse Mortality after Autologous Hematopoietic Cell Transplantation. / 12.2019 / PubMed / Full text

NRXN3

Low expression of aging-related [[NRXN3]] is associated with Alzheimer disease: A systematic review and meta-analysis. / 07.2018 / PubMed / Full text

NSF

Effects of air pollution on children from a socioecological perspective. / 15.11.2019 / PubMed / Full text

NT5E

The NT5E gene variant strongly affects the degradation rate of inosine 5'-monophosphate under postmortem conditions in Japanese Black beef. / 12.2019 / PubMed / Full text

NTHL1

Mitochondrial base excision repair positively correlates with longevity in the liver and heart of mammals. / 04.2020 / PubMed / Full text

NTN4

EGF/EGFR upregulates and cooperates with Netrin-4 to protect glioblastoma cells from DNA damage-induced senescence. / 04.12.2018 / PubMed / Full text

NUCB2

Ontogenetic Pattern Changes of Nucleobindin-2/Nesfatin-1 in the Brain and Intestinal Bulb of the Short Lived African Turquoise Killifish. / 31.12.2019 / PubMed / Full text

NUPR1

NUPR1 maintains autolysosomal efflux by activating SNAP25 transcription in cancer cells. / 2018 / PubMed / Full text

OCLN

Reduction of Aging-Induced Oxidative Stress and Activation of Autophagy by Bilberry Anthocyanin Supplementation via the AMPK-mTOR Signaling Pathway in Aged Female Rats. / 17.07.2019 / PubMed / Full text

OGA

NPGPx-Mediated Adaptation to Oxidative Stress Protects Motor Neurons from Degeneration in Aging by Directly Modulating O-GlcNAcase. / 19.11.2019 / PubMed / Full text

OLFML3

Dexamethasone Induces a Specific Form of Ramified Dysfunctional Microglia. / 02.2019 / PubMed / Full text

OMD

Genome-wide associations and detection of potential candidate genes for direct genetic and maternal genetic effects influencing dairy cattle body weight at different ages. / 06.02.2019 / PubMed / Full text

OOEP

Maternal gene [i]Ooep[/i] may participate in homologous recombination-mediated DNA double-strand break repair in mouse oocytes. / 18.11.2018 / PubMed / Full text

OSGEP

Novel homozygous OSGEP gene pathogenic variants in two unrelated patients with Galloway-Mowat syndrome: case report and review of the literature. / 11.04.2019 / PubMed / Full text

OSM

Age Differences in Sexual Minority Stress and the Importance of Friendship in Later Life. / 04.11.2020 / PubMed / Full text

OTX2

Tau Deficiency Down-Regulated Transcription Factor Orthodenticle Homeobox 2 Expression in the Dopaminergic Neurons in Ventral Tegmental Area and Caused No Obvious Motor Deficits in Mice. / 01.03.2018 / PubMed / Full text

OXR1

Oxidation resistance 1 is a novel senolytic target. / 08.2018 / PubMed / Full text

P2RY10

Divergent age-dependent peripheral immune transcriptomic profile following traumatic brain injury. / 12.06.2019 / PubMed / Full text

P4HA2

Expanding the Phenotypic and Genotypic Landscape of Nonsyndromic High Myopia: A Cross-Sectional Study in 731 Chinese Patients. / 03.09.2019 / PubMed / Full text

P4HA3

Age-associated genes in human mammary gland drive human breast cancer progression. / 15.06.2020 / PubMed / Full text

PABPN1

Dysfunctional transcripts are formed by alternative polyadenylation in OPMD. / 26.09.2017 / PubMed / Full text

PAFAH2

Elevated truncated oxidized phospholipids as a factor exacerbating ALI in the aging lungs. / 03.2019 / PubMed / Full text

PARK7

The genetic component of human longevity: New insights from the analysis of pathway-based SNP-SNP interactions. / 06.2018 / PubMed / Full text

PAX1

Co-culturing nucleus pulposus mesenchymal stem cells with notochordal cell-rich nucleus pulposus explants attenuates tumor necrosis factor-α-induced senescence. / 26.06.2018 / PubMed / Full text

PAX5

Diminished antibody response to influenza vaccination is characterized by expansion of an age-associated B-cell population with low PAX5. / 08.2018 / PubMed / Full text

PAX7

Muscle health and performance in monozygotic twins with 30 years of discordant exercise habits. / 10.2018 / PubMed / Full text

PAX8

Inadequate control of thyroid hormones sensitizes to hepatocarcinogenesis and unhealthy aging. / 13.09.2019 / PubMed / Full text

PBX1

Internalization of the TAT-PBX1 fusion protein significantly enhances the proliferation of human hair follicle-derived mesenchymal stem cells and delays their senescence. / 10.2020 / PubMed / Full text

PCCA

Propionyl-CoA carboxylase pcca-1 and pccb-1 gene deletions in Caenorhabditis elegans globally impair mitochondrial energy metabolism. / 03.2018 / PubMed / Full text

PCCB

Propionyl-CoA carboxylase pcca-1 and pccb-1 gene deletions in Caenorhabditis elegans globally impair mitochondrial energy metabolism. / 03.2018 / PubMed / Full text

PCDHGA3

DNA methylation associated with healthy aging of elderly twins. / 12.2018 / PubMed / Full text

PCMTD1

Genome-wide association study and annotating candidate gene networks affecting age at first calving in Nellore cattle. / 12.2017 / PubMed / Full text

PDE10A

Cyclic nucleotide signaling changes associated with normal aging and age-related diseases of the brain. / 01.2018 / PubMed / Full text

PDE2A

TAK-915, a phosphodiesterase 2A inhibitor, ameliorates the cognitive impairment associated with aging in rodent models. / 30.12.2019 / PubMed / Full text

PDE4B

Phosphodiesterase-4B as a Therapeutic Target for Cognitive Impairment and Obesity-Related Metabolic Diseases. / 2017 / PubMed / Full text

PDE4C

Effect of adding B-vitamins to vitamin D and calcium supplementation on CpG methylation of epigenetic aging markers. / 04.2018 / PubMed / Full text

PDE5A

Repurposing erectile dysfunction drugs tadalafil and vardenafil to increase bone mass. / 23.06.2020 / PubMed / Full text

PDE9A

Identification of new PDE9A isoforms and how their expression and subcellular compartmentalization in the brain change across the life span. / 05.2018 / PubMed / Full text

PDF

Effects of MUL1 and PARKIN on the circadian clock, brain and behaviour in Drosophila Parkinson's disease models. / 28.05.2019 / PubMed / Full text

PDGFRB

A tyrosine kinase-activating variant Asn666Ser in PDGFRB causes a progeria-like condition in the severe end of Penttinen syndrome. / 04.2019 / PubMed / Full text

PDHB

Neuron-specific knockdown of Drosophila PDHB induces reduction of lifespan, deficient locomotive ability, abnormal morphology of motor neuron terminals and photoreceptor axon targeting. / 15.05.2018 / PubMed / Full text

PDK4

Putrescine delays postovulatory aging of mouse oocytes by upregulating PDK4 expression and improving mitochondrial activity. / 16.12.2018 / PubMed / Full text

PEBP1

[i]Drosophila[/i] PEBP1 inhibits intestinal stem cell aging via suppression of ERK pathway. / 06.04.2018 / PubMed / Full text

PER3

Effects of PER3 clock gene polymorphisms on aging-related changes of the cerebral cortex. / 03.2018 / PubMed / Full text

PES1

Transcription factor RD26 is a key regulator of metabolic reprogramming during dark-induced senescence. / 06.2018 / PubMed / Full text

PEX19

A genome-wide screen identifies genes that suppress the accumulation of spontaneous mutations in young and aged yeast cells. / 02.2020 / PubMed / Full text

PEX5

Aging lowers PEX5 levels in cortical neurons in male and female mouse brains. / 09.2020 / PubMed / Full text

PF4V1

Involvement of ERK1/2 activation in the gene expression of senescence-associated secretory factors in human hepatic stellate cells. / 05.2019 / PubMed / Full text

PFKFB3

DNA damage, metabolism and aging in pro-inflammatory T cells: Rheumatoid arthritis as a model system. / 05.2018 / PubMed / Full text

PGAP1

Hypoxia-inducible transcription factors, HIF1A and HIF2A, increase in aging mucosal tissues. / 07.2018 / PubMed / Full text

PGK2

Arsenic influences spermatogenesis by disorganizing the elongation of spermatids in adult male mice. / 01.2020 / PubMed / Full text

PGLS

547 transcriptomes from 44 brain areas reveal features of the aging brain in non-human primates. / 28.11.2019 / PubMed / Full text

PGM1

Explaining meat quality of bulls and steers by differential proteome and phosphoproteome analysis of skeletal muscle. / 15.05.2019 / PubMed / Full text

PHB

Ubiquinol-cytochrome C reductase core protein II promotes tumorigenesis by facilitating p53 degradation. / 02.2019 / PubMed / Full text

PHB2

Prohibitin-2 is a novel regulator of p21 induced by depletion of γ-glutamylcyclotransferase. / 29.01.2018 / PubMed / Full text

PHGDH

Tanshinone prevents alveolar bone loss in ovariectomized osteoporosis rats by up-regulating phosphoglycerate dehydrogenase. / 01.08.2019 / PubMed / Full text

PIGR

Proteomics and metabolomics identify molecular mechanisms of aging potentially predisposing for chronic lymphocytic leukemia. / 02.2018 / PubMed / Full text

PIK3C2A

Identification of key genes and transcription factors in aging mesenchymal stem cells by DNA microarray data. / 15.04.2019 / PubMed / Full text

PIK3R1

Analysis of Polymorphisms in 59 Potential Candidate Genes for Association With Human Longevity. / 08.10.2018 / PubMed / Full text

PIK3R2

The senescent status of endothelial cells affects proliferation, inflammatory profile and SOX2 expression in bone marrow-derived mesenchymal stem cells. / 06.2019 / PubMed / Full text

PIM1

PIM1-catalyzed CBX8 phosphorylation promotes the oncogene-induced senescence of human diploid fibroblast. / 27.06.2018 / PubMed / Full text

PIP5K1C

[Target protein candidates of hypothalamus in aging rats with intervention by Qiongyugao]. / 04.2016 / PubMed / Full text

PKD1

The protein kinase D1-mediated classical protein secretory pathway regulates the Ras oncogene-induced senescence response. / 16.03.2018 / PubMed / Full text

PLA2G6

Mutations in the Drosophila homolog of human PLA2G6 give rise to age-dependent loss of psychomotor activity and neurodegeneration. / 13.02.2018 / PubMed / Full text

PLA2R1

Targeting the phospholipase A2 receptor ameliorates premature aging phenotypes. / 12.2018 / PubMed / Full text

PLCG2

A nonsynonymous mutation in PLCG2 reduces the risk of Alzheimer's disease, dementia with Lewy bodies and frontotemporal dementia, and increases the likelihood of longevity. / 08.2019 / PubMed / Full text

PLD3

Whole-Exome Sequencing of an Exceptional Longevity Cohort. / 16.08.2019 / PubMed / Full text

PLK1

Dynactin pathway-related gene expression is altered by aging, but not by vitrification. / 09.2019 / PubMed / Full text

PLN

An analysis of the costs of treating aged patients in a large clinical hospital in Poland under the pressure of recent demographic trends. / 2020 / PubMed / Full text

PLXNA4

Novel molecular mechanisms for the adaptogenic effects of herbal extracts on isolated brain cells using systems biology. / 15.11.2018 / PubMed / Full text

PMP22

Role of microRNAs in senescence and its contribution to peripheral neuropathy in the arsenic exposed population of West Bengal, India. / 02.2018 / PubMed / Full text

PMS1

RNA-Seq analysis of differentially expressed genes relevant to mismatch repair in aging hematopoietic stem-progenitor cells. / 25.02.2019 / PubMed / Full text

PMS2

RNA-Seq analysis of differentially expressed genes relevant to mismatch repair in aging hematopoietic stem-progenitor cells. / 25.02.2019 / PubMed / Full text

POLG2

An N-Ethyl-N-Nitrosourea (ENU)-Induced Tyr265Stop Mutation of the DNA Polymerase Accessory Subunit Gamma 2 (Polg2) Is Associated With Renal Calcification in Mice. / 03.2019 / PubMed / Full text

POLL

Temporal trends in loss of life expectancy after a cancer diagnosis among the Australian population. / 04.2020 / PubMed / Full text

POLR3A

Nucleolar disruption, activation of P53 and premature senescence in POLR3A-mutated Wiedemann-Rautenstrauch syndrome fibroblasts. / 12.2020 / PubMed / Full text

PON1

Paraoxonases Activities and Polymorphisms in Elderly and Old-Age Diseases: An Overview. / 02.05.2019 / PubMed / Full text

POU3F2

POU3F2 participates in cognitive function and adult hippocampal neurogenesis via mammalian-characteristic amino acid repeats. / 02.2018 / PubMed / Full text

POU5F1

Cell quality evaluation with gene expression analysis of spheroids (3D) and adherent (2D) adipose stem cells. / 24.10.2020 / PubMed / Full text

PPA2

Characterization of long living yeast deletion mutants that lack mitochondrial metabolism genes DSS1, PPA2 and AFG3. / 20.07.2019 / PubMed / Full text

PPARG

The PPARG Pro12Ala Polymorphism and 20-year Cognitive Decline: Race and Sex Heterogeneity. / 04-06.2018 / PubMed / Full text

PPARGC1A

Maternal ageing impairs mitochondrial DNA kinetics during early embryogenesis in mice. / 08.07.2019 / PubMed / Full text

PPFIA1

Explorative results from multistep screening for potential genetic risk loci of Alzheimer's disease in the longitudinal VITA study cohort. / 01.2018 / PubMed / Full text

PPM1A

The TGF-β1/p53/PAI-1 Signaling Axis in Vascular Senescence: Role of Caveolin-1. / 03.08.2019 / PubMed / Full text

PPP1R3C

Uncovering genetic mechanisms of kidney aging through transcriptomics, genomics, and epigenomics. / 03.2019 / PubMed / Full text

PPP2R1A

Identification of key genes and transcription factors in aging mesenchymal stem cells by DNA microarray data. / 15.04.2019 / PubMed / Full text

PPP2R3C

The mir-465 family is upregulated with age and attenuates growth hormone signaling in mouse liver. / 04.2019 / PubMed / Full text

PPP3CB

Gene Expression Analysis Reveals Novel Gene Signatures Between Young and Old Adults in Human Prefrontal Cortex. / 2018 / PubMed / Full text

PRDM1

Age-related changes in the BACH2 and PRDM1 genes in lymphocytes from healthy donors and chronic lymphocytic leukemia patients. / 17.01.2019 / PubMed / Full text

PRDM16

Assessment of the Aging of the Brown Adipose Tissue by F-FDG PET/CT Imaging in the Progeria Mouse Model Lmna . / 2018 / PubMed / Full text

PRDM8

PRDM8 reveals aberrant DNA methylation in aging syndromes and is relevant for hematopoietic and neuronal differentiation. / 20.08.2020 / PubMed / Full text

PRDX6

Dentate Gyrus Peroxiredoxin 6 Levels Discriminate Aged Unimpaired From Impaired Rats in a Spatial Memory Task. / 2019 / PubMed / Full text

PREP

Genome-wide association study and annotating candidate gene networks affecting age at first calving in Nellore cattle. / 12.2017 / PubMed / Full text

PRG4

Inhibition of Wnt/β-catenin signaling ameliorates osteoarthritis in a murine model of experimental osteoarthritis. / 08.02.2018 / PubMed / Full text

PRKAA1

Therapeutic and preventive effects of exercise on cardiometabolic parameters in aging and obese rats. / 02.2019 / PubMed / Full text

PRKCB

MEF2A alters the proliferation, inflammation-related gene expression profiles and its silencing induces cellular senescence in human coronary endothelial cells. / 18.03.2019 / PubMed / Full text

PRKCH

Novel molecular mechanisms for the adaptogenic effects of herbal extracts on isolated brain cells using systems biology. / 15.11.2018 / PubMed / Full text

PRKDC

DNA-PKcs modulates progenitor cell proliferation and fibroblast senescence in idiopathic pulmonary fibrosis. / 29.08.2019 / PubMed / Full text

PRKG1

Long-term inhibition of PDE5 ameliorates aging-induced changes in rat testis. / 15.07.2018 / PubMed / Full text

PRKN

PRKN-regulated mitophagy and cellular senescence during COPD pathogenesis. / 03.2019 / PubMed / Full text

PRLR

Novel molecular mechanisms for the adaptogenic effects of herbal extracts on isolated brain cells using systems biology. / 15.11.2018 / PubMed / Full text

PRM1

Cytological and molecular aspects of the ageing sperm. / 01.02.2019 / PubMed / Full text

PRM2

Cytological and molecular aspects of the ageing sperm. / 01.02.2019 / PubMed / Full text

PRMT1

Reactive oxygen species extend insect life span using components of the insulin-signaling pathway. / 12.09.2017 / PubMed / Full text

PRMT8

Arginine Methyltransferase PRMT8 Provides Cellular Stress Tolerance in Aging Motoneurons. / 29.08.2018 / PubMed / Full text

PRNP

Spontaneous generation of prions and transmissible PrP amyloid in a humanised transgenic mouse model of A117V GSS. / 06.2020 / PubMed / Full text

PRR9

Circadian control of [i]ORE1[/i] by PRR9 positively regulates leaf senescence in [i]Arabidopsis[/i]. / 14.08.2018 / PubMed / Full text

PRRX1

A SIRT1-centered circuitry regulates breast cancer stemness and metastasis. / 12.2018 / PubMed / Full text

PSAP

Prosaposin and its receptors are differentially expressed in the salivary glands of male and female rats. / 08.2018 / PubMed / Full text

PSMB8

[Target protein candidates of hypothalamus in aging rats with intervention by Qiongyugao]. / 04.2016 / PubMed / Full text

PSMD11

The effect and mechanism of 19S proteasome PSMD11/Rpn6 subunit in D-Galactose induced mimetic aging models. / 01.09.2020 / PubMed / Full text

PSMD13

Lifelong Football Training: Effects on Autophagy and Healthy Longevity Promotion. / 2019 / PubMed / Full text

PSMD14

Upregulation of deubiquitinase PSMD14 in lung adenocarcinoma (LUAD) and its prognostic significance. / 2020 / PubMed / Full text

PSMG1

Long-lived rodents reveal signatures of positive selection in genes associated with lifespan. / 03.2018 / PubMed / Full text

PTCH1

Sonic hedgehog regulation of cavernous nerve regeneration and neurite formation in aged pelvic plexus. / 02.2019 / PubMed / Full text

PTGS2

Senescent thyrocytes and thyroid tumor cells induce M2-like macrophage polarization of human monocytes via a PGE2-dependent mechanism. / 21.05.2019 / PubMed / Full text

PTK2B

Integrative transcriptome analyses of the aging brain implicate altered splicing in Alzheimer's disease susceptibility. / 11.2018 / PubMed / Full text

PTK7

Innate and adaptive immune dysregulation in critically ill ICU patients. / 05.07.2018 / PubMed / Full text

PTN

Connecting Metainflammation and Neuroinflammation Through the PTN-MK-RPTPβ/ζ Axis: Relevance in Therapeutic Development. / 2019 / PubMed / Full text

PTP4A3

Transcriptional and Functional Changes of the Human Microvasculature during Physiological Aging and Alzheimer Disease. / 05.2020 / PubMed / Full text

PTPN1

The genetic component of human longevity: New insights from the analysis of pathway-based SNP-SNP interactions. / 06.2018 / PubMed / Full text

PTPRC

Selective molecular biomarkers to predict biologic behavior in pituitary tumors. / 05.2017 / PubMed / Full text

PTPRD

Novel molecular mechanisms for the adaptogenic effects of herbal extracts on isolated brain cells using systems biology. / 15.11.2018 / PubMed / Full text

PTPRR

Novel molecular mechanisms for the adaptogenic effects of herbal extracts on isolated brain cells using systems biology. / 15.11.2018 / PubMed / Full text

PTTG1

[Down-regulated PTTG1 expression promotes the senescence of human prostate cancer LNCaP-AI]. / 03.2019 / PubMed

PUM1

Identification of reference genes for RT-qPCR data normalisation in aging studies. / 27.09.2019 / PubMed / Full text

PYCR1

A Transcriptome Study of Progeroid Neurocutaneous Syndrome Reveals POSTN As a New Element in Proline Metabolic Disorder. / 12.2018 / PubMed / Full text

QRFPR

Explorative results from multistep screening for potential genetic risk loci of Alzheimer's disease in the longitudinal VITA study cohort. / 01.2018 / PubMed / Full text

RAB1B

Lifelong Football Training: Effects on Autophagy and Healthy Longevity Promotion. / 2019 / PubMed / Full text

RACK1

Invariable stoichiometry of ribosomal proteins in mouse brain tissues with aging. / 05.11.2019 / PubMed / Full text

RAD23A

Lifelong Football Training: Effects on Autophagy and Healthy Longevity Promotion. / 2019 / PubMed / Full text

RAD50

Transactivation domain of p53 regulates DNA repair and integrity in human iPS cells. / 01.09.2018 / PubMed / Full text

RAD51B

Increased age-adjusted hazard of death associated with a common single nucleotide polymorphism of the human RAD52 gene in a cardiovascular cohort. / 10.2017 / PubMed / Full text

RAD51C

Polymorphisms of the DNA repair gene EXO1 modulate cognitive aging in old adults in a Taiwanese population. / 06.2019 / PubMed / Full text

RAD9A

Proteomics and metabolomics identify molecular mechanisms of aging potentially predisposing for chronic lymphocytic leukemia. / 02.2018 / PubMed / Full text

RAF1

Circular [i]ANRIL[/i] isoforms switch from repressors to activators of [i]p15/CDKN2B[/i] expression during RAF1 oncogene-induced senescence. / 29.09.2020 / PubMed / Full text

RAG2

Phosphate Transporter Profiles in Murine and Human Thymi Identify Thymocytes at Distinct Stages of Differentiation. / 2020 / PubMed / Full text

RAI1

DNA methylation analysis on purified neurons and glia dissects age and Alzheimer's disease-specific changes in the human cortex. / 25.07.2018 / PubMed / Full text

RARB

Genome-wide meta-analysis of macronutrient intake of 91,114 European ancestry participants from the cohorts for heart and aging research in genomic epidemiology consortium. / 12.2019 / PubMed / Full text

RB1

G protein-coupled receptor kinase 4-induced cellular senescence and its senescence-associated gene expression profiling. / 15.11.2017 / PubMed / Full text

RBM25

HPV shapes tumor transcriptome by globally modifying the pool of RNA binding protein-binding motif. / 29.04.2019 / PubMed / Full text

RBM3

Infants Uniquely Express High Levels of RBM3 and Other Cold-Adaptive Neuroprotectant Proteins in the Human Brain. / 2018 / PubMed / Full text

RBM38

Genetic Ablation of [i]Rbm38[/i] Promotes Lymphomagenesis in the Context of Mutant p53 by Downregulating PTEN. / 15.03.2018 / PubMed / Full text

RBMXL1

Whole-Exome Sequencing of an Exceptional Longevity Cohort. / 16.08.2019 / PubMed / Full text

RBP1

The SR proteins SF2 and RBP1 regulate triglyceride storage in the fat body of Drosophila. / 27.08.2019 / PubMed / Full text

RBP4

[Effects of different intensities exercise combined with resveratrol on RBP4 in aged obese rats]. / 08.05.2017 / PubMed / Full text

RCAN1

Mitochondrial dysfunction and endoplasmic reticulum stress involved in oocyte aging: an analysis using single-cell RNA-sequencing of mouse oocytes. / 08.06.2019 / PubMed / Full text

REC8

Effects of Heyan Kuntai Capsule () on Follicular Development and Oocyte Cohesin Levels in Aged Mice. / 10.2018 / PubMed / Full text

RELA

Genome-wide association study and annotating candidate gene networks affecting age at first calving in Nellore cattle. / 12.2017 / PubMed / Full text

RELB

New control of the senescence barrier in breast cancer. / 2020 / PubMed / Full text

REV1

REV1 inhibitor JH-RE-06 enhances tumor cell response to chemotherapy by triggering senescence hallmarks. / 17.11.2020 / PubMed / Full text

RGS14

Enhanced longevity and metabolism by brown adipose tissue with disruption of the regulator of G protein signaling 14. / 08.2018 / PubMed / Full text

RGS2

Downregulation of thromboxane A2 and angiotensin II type 1 receptors associated with aging-related decrease in internal anal sphincter tone. / 01.05.2019 / PubMed / Full text

RHCG

Rh type C-glycoprotein functions as a novel tumor suppressor gene by inhibiting tumorigenicity and metastasis in head and neck squamous cell carcinoma. / 06.06.2019 / PubMed / Full text

RHEBL1

Long-lived rodents reveal signatures of positive selection in genes associated with lifespan. / 03.2018 / PubMed / Full text

RHOB

Regulation of RhoB Gene Expression during Tumorigenesis and Aging Process and Its Potential Applications in These Processes. / 13.06.2019 / PubMed / Full text

RICTOR

Endothelial senescence-associated secretory phenotype (SASP) is regulated by Makorin-1 ubiquitin E3 ligase. / 11.2019 / PubMed / Full text

RIF1

53BP1 Enforces Distinct Pre- and Post-resection Blocks on Homologous Recombination. / 02.01.2020 / PubMed / Full text

RIMS2

Age-related gene and miRNA expression changes in airways of healthy individuals. / 06.03.2019 / PubMed / Full text

RIPK2

RIP kinases as modulators of inflammation and immunity. / 09.2018 / PubMed / Full text

RNF10

Reduced RING finger protein 10 expression in macrophages is associated with aging-related inflammation. / 28.11.2020 / PubMed / Full text

RNF13

The effects of environmental stressors on candidate aging associated genes. / 08.2020 / PubMed / Full text

RNF144A

Identification of age- and gender-associated long noncoding RNAs in the human brain with Alzheimer's disease. / 09.2019 / PubMed / Full text

RNF168

PML nuclear bodies are recruited to persistent DNA damage lesions in an RNF168-53BP1 dependent manner and contribute to DNA repair. / 06.2019 / PubMed / Full text

RORA

Novel molecular mechanisms for the adaptogenic effects of herbal extracts on isolated brain cells using systems biology. / 15.11.2018 / PubMed / Full text

ROS1

Novel molecular mechanisms for the adaptogenic effects of herbal extracts on isolated brain cells using systems biology. / 15.11.2018 / PubMed / Full text

RPA2

Chronological age prediction based on DNA methylation: Massive parallel sequencing and random forest regression. / 11.2017 / PubMed / Full text

RPE65

Effects of Ranibizumab, Bevacizumab, and Aflibercept on Senescent Retinal Pigment Epithelial Cells. / 08.2018 / PubMed / Full text

RPIA

Suppression of p16 Induces mTORC1-Mediated Nucleotide Metabolic Reprogramming. / 20.08.2019 / PubMed / Full text

RPL11

NOL12 Repression Induces Nucleolar Stress-Driven Cellular Senescence and Is Associated with Normative Aging. / 15.06.2019 / PubMed / Full text

RPL13

Selection of a Real-Time PCR Housekeeping Gene Panel in Human Endothelial Colony Forming Cells for Cellular Senescence Studies. / 2019 / PubMed / Full text

RPL30

Selection of a Real-Time PCR Housekeeping Gene Panel in Human Endothelial Colony Forming Cells for Cellular Senescence Studies. / 2019 / PubMed / Full text

RPL31

Selection of a Real-Time PCR Housekeeping Gene Panel in Human Endothelial Colony Forming Cells for Cellular Senescence Studies. / 2019 / PubMed / Full text

RPL36

Lifelong Football Training: Effects on Autophagy and Healthy Longevity Promotion. / 2019 / PubMed / Full text

RPL37

Selection of a Real-Time PCR Housekeeping Gene Panel in Human Endothelial Colony Forming Cells for Cellular Senescence Studies. / 2019 / PubMed / Full text

RPL4

Lifelong Football Training: Effects on Autophagy and Healthy Longevity Promotion. / 2019 / PubMed / Full text

RPS19BP1

Material basis, effect, and mechanism of ethanol extract of Pinellia ternata tubers on oxidative stress-induced cell senescence. / 10.2020 / PubMed / Full text

RPS6KB1

Inhibition of glioma growth by flavokawain B is mediated through endoplasmic reticulum stress induced autophagy. / 2018 / PubMed / Full text

RPTOR

Endothelial replicative senescence delayed by the inhibition of MTORC1 signaling involves MicroRNA-107. / 08.2018 / PubMed / Full text

RRAD

Pan-senescence transcriptome analysis identified RRAD as a marker and negative regulator of cellular senescence. / 01.2019 / PubMed / Full text

RRM1

α-Synuclein toxicity in yeast and human cells is caused by cell cycle re-entry and autophagy degradation of ribonucleotide reductase 1. / 08.2019 / PubMed / Full text

RRM2B

Troponin T3 associates with DNA consensus sequence that overlaps with p53 binding motifs. / 15.07.2018 / PubMed / Full text

RSF1

The SR proteins SF2 and RBP1 regulate triglyceride storage in the fat body of Drosophila. / 27.08.2019 / PubMed / Full text

RTN4

Cell fate regulation by reticulon-4 in human prostate cancers. / 07.2019 / PubMed / Full text

RUNX3

circLARP4 induces cellular senescence through regulating miR-761/RUNX3/p53/p21 signaling in hepatocellular carcinoma. / 02.2019 / PubMed / Full text

RXFP3

The RXFP3 receptor is functionally associated with cellular responses to oxidative stress and DNA damage. / 03.12.2019 / PubMed / Full text

RXRA

The nuclear receptor RXRA controls cellular senescence by regulating calcium signaling. / 12.2018 / PubMed / Full text

RXRG

Genetic variations, reproductive aging, and breast cancer risk in African American and European American women: The Women's Circle of Health Study. / 2017 / PubMed / Full text

S100A12

Fetal articular cartilage regeneration versus adult fibrocartilaginous repair: secretome proteomics unravels molecular mechanisms in an ovine model. / 06.07.2018 / PubMed / Full text

S100A13

S100A13 promotes senescence-associated secretory phenotype and cellular senescence via modulation of non-classical secretion of IL-1α. / 23.01.2019 / PubMed / Full text

S100A6

Sex differences in distribution of cannabinoid receptors (CB1 and CB2), S100A6 and CacyBP/SIP in human ageing hearts. / 27.11.2018 / PubMed / Full text

S1PR3

Sexual dimorphism of metabolic and vascular dysfunction in aged mice and those lacking the sphingosine 1-phosphate receptor 3. / 01.12.2017 / PubMed / Full text

SAA2

Naturally occurring antibodies against serum amyloid A reduce IL-6 release from peripheral blood mononuclear cells. / 2018 / PubMed / Full text

SALL1

SALL1 functions as a tumor suppressor in breast cancer by regulating cancer cell senescence and metastasis through the NuRD complex. / 06.04.2018 / PubMed / Full text

SAMD10

Chronological age prediction based on DNA methylation: Massive parallel sequencing and random forest regression. / 11.2017 / PubMed / Full text

SAMD12

Genome-wide scan of depressive symptomatology in two representative cohorts in the United States and the United Kingdom. / 05.2018 / PubMed / Full text

SARM1

Sarm1 Deletion, but Not Wld , Confers Lifelong Rescue in a Mouse Model of Severe Axonopathy. / 03.10.2017 / PubMed / Full text

SAT1

Triethylenetetramine (trientine): a caloric restriction mimetic with a new mode of action. / 08.2020 / PubMed / Full text

SATB2

microRNA-31 inhibition partially ameliorates the deficiency of bone marrow stromal cells from cleidocranial dysplasia. / 06.2019 / PubMed / Full text

SCAMP4

SCAMP4 enhances the senescent cell secretome. / 01.07.2018 / PubMed / Full text

SCGN

Detection and evaluation of DNA methylation markers found at SCGN and KLF14 loci to estimate human age. / 11.2017 / PubMed / Full text

SCN2A

Na 1.2 haploinsufficiency in Scn2a knock-out mice causes an autistic-like phenotype attenuated with age. / 09.09.2019 / PubMed / Full text

SCN2B

MicroRNA‑449a regulates the progression of brain aging by targeting SCN2B in SAMP8 mice. / 04.2020 / PubMed / Full text

SCN5A

[Use of Pharmacogenetic Information for Therapeutic Drug Monitoring of an Antiarrhythmic Drug]. / 2018 / PubMed / Full text

SCN9A

The SCN9A channel and plasma membrane depolarization promote cellular senescence through Rb pathway. / 06.2018 / PubMed / Full text

SCNN1B

Bitter, Sweet, Salty, Sour and Umami Taste Perception Decreases with Age: Sex-Specific Analysis, Modulation by Genetic Variants and Taste-Preference Associations in 18 to 80 Year-Old Subjects. / 18.10.2018 / PubMed / Full text

SCO1

Real-Time PCR Analysis of Metabolism-Related Genes in a Long-Lived Model of C. elegans. / 2020 / PubMed / Full text

SCX

Novel molecular mechanisms for the adaptogenic effects of herbal extracts on isolated brain cells using systems biology. / 15.11.2018 / PubMed / Full text

SDC2

Alterations in Corneal Sensory Nerves During Homeostasis, Aging, and After Injury in Mice Lacking the Heparan Sulfate Proteoglycan Syndecan-1. / 01.10.2017 / PubMed / Full text

SDC3

Alterations in Corneal Sensory Nerves During Homeostasis, Aging, and After Injury in Mice Lacking the Heparan Sulfate Proteoglycan Syndecan-1. / 01.10.2017 / PubMed / Full text

SDC4

Alterations in Corneal Sensory Nerves During Homeostasis, Aging, and After Injury in Mice Lacking the Heparan Sulfate Proteoglycan Syndecan-1. / 01.10.2017 / PubMed / Full text

SDHB

Mitochondrial Signatures in Circulating Extracellular Vesicles of Older Adults with Parkinson's Disease: Results from the EXosomes in PArkiNson's Disease (EXPAND) Study. / 12.02.2020 / PubMed / Full text

SELENBP1

A Caenorhabditis elegans ortholog of human selenium-binding protein 1 is a pro-aging factor protecting against selenite toxicity. / 01.2020 / PubMed / Full text

SELENOH

The Thioredoxin-Like Family of Selenoproteins: Implications in Aging and Age-Related Degeneration. / 03.2019 / PubMed / Full text

SELENOK

Dietary selenium deficiency and supplementation differentially modulate the expression of two ER-resident selenoproteins (selenoprotein K and selenoprotein M) in the ovaries of aged mice: Preliminary data. / 09.2020 / PubMed / Full text

SELENOP

Analyses of Selenotranscriptomes and Selenium Concentrations in Response to Dietary Selenium Deficiency and Age Reveal Common and Distinct Patterns by Tissue and Sex in Telomere-Dysfunctional Mice. / 10.2017 / PubMed / Full text

SELENOT

The Thioredoxin-Like Family of Selenoproteins: Implications in Aging and Age-Related Degeneration. / 03.2019 / PubMed / Full text

SELENOV

The Thioredoxin-Like Family of Selenoproteins: Implications in Aging and Age-Related Degeneration. / 03.2019 / PubMed / Full text

SELENOW

The Thioredoxin-Like Family of Selenoproteins: Implications in Aging and Age-Related Degeneration. / 03.2019 / PubMed / Full text

SEMA3A

Autoregulation of Osteocyte Sema3A Orchestrates Estrogen Action and Counteracts Bone Aging. / 05.03.2019 / PubMed / Full text

SEMA6C

Suppression of SEMA6C promotes preantral follicles atresia with decreased cell junctions in mice ovaries. / 04.2019 / PubMed / Full text

SENP1

Aging-related SUMOylation pattern in the cortex and blood plasma of wild type mice. / 06.03.2018 / PubMed / Full text

SENP6

Molecular signature for senile and complicated cataracts derived from analysis of sumoylation enzymes and their substrates in human cataract lenses. / 10.2020 / PubMed / Full text

SERPINA1

Proteomic profiling of follicle fluids after superstimulation in one-month-old lambs. / 02.2018 / PubMed / Full text

SERPINB2

An Endogenous Anti-aging Factor, Sonic Hedgehog, Suppresses Endometrial Stem Cell Aging through SERPINB2. / 03.07.2019 / PubMed / Full text

SESN1

Sestrins are differentially expressed with age in the skeletal muscle of men: A cross-sectional analysis. / 09.2018 / PubMed / Full text

SESN3

Autophagy mediators (FOXO1, SESN3 and TSC2) in Lewy body disease and aging. / 25.09.2018 / PubMed / Full text

SF1

Prepubertal exposure to perfluorononanoic acid interferes with spermatogenesis and steroidogenesis in male mice. / 15.04.2019 / PubMed / Full text

SFPQ

Downregulation of LncRNA NORAD promotes Ox-LDL-induced vascular endothelial cell injury and atherosclerosis. / 08.04.2020 / PubMed / Full text

SFRP1

[Role and alterations of DNA methylation during the aging and cancer]. / 01.2018 / PubMed / Full text

SFRP2

[Role and alterations of DNA methylation during the aging and cancer]. / 01.2018 / PubMed / Full text

SFRP5

SFRP5 serves a beneficial role in arterial aging by inhibiting the proliferation, migration and inflammation of smooth muscle cells. / 11.2018 / PubMed / Full text

SGK1

Epigenetic Regulation of KL (Klotho) via H3K27me3 (Histone 3 Lysine [K] 27 Trimethylation) in Renal Tubule Cells. / 05.2020 / PubMed / Full text

SGSH

MPS-IIIA mice acquire autistic behaviours with age. / 07.2018 / PubMed / Full text

SH2B3

Genome-wide meta-analysis associates HLA-DQA1/DRB1 and LPA and lifestyle factors with human longevity. / 13.10.2017 / PubMed / Full text

SHANK3

Spontaneous seizure and partial lethality of juvenile Shank3-overexpressing mice in C57BL/6 J background. / 10.10.2018 / PubMed / Full text

SHD

Does self-reported hearing difficulty decrease older adults' cognitive and physical functioning? The mediating role of social isolation. / 11.2020 / PubMed / Full text

SIK3

Quantitative and Qualitative Role of Antagonistic Heterogeneity in Genetics of Blood Lipids. / 25.09.2020 / PubMed / Full text

SIL1

SIL1, the endoplasmic-reticulum-localized BiP co-chaperone, plays a crucial role in maintaining skeletal muscle proteostasis and physiology. / 10.05.2018 / PubMed / Full text

SIX3

CellBIC: bimodality-based top-down clustering of single-cell RNA sequencing data reveals hierarchical structure of the cell type. / 30.11.2018 / PubMed / Full text

SKAP2

Longevity-related molecular pathways are subject to midlife "switch" in humans. / 08.2019 / PubMed / Full text

SKI

Preventive effect of Shenkang injection against high glucose-induced senescence of renal tubular cells. / 04.2019 / PubMed / Full text

SLC15A1

Molecular changes to the rat renal cotransporters PEPT1 and PEPT2 due to ageing. / 02.2019 / PubMed / Full text

SLC15A2

Molecular changes to the rat renal cotransporters PEPT1 and PEPT2 due to ageing. / 02.2019 / PubMed / Full text

SLC16A7

Genetics of facial telangiectasia in the Rotterdam Study: a genome-wide association study and candidate gene approach. / 23.10.2020 / PubMed / Full text

SLC19A1

Novel drug-resistance mechanisms of pemetrexed-treated non-small cell lung cancer. / 30.03.2018 / PubMed / Full text

SLC1A5

SLC1A5 glutamine transporter is a target of MYC and mediates reduced mTORC1 signaling and increased fatty acid oxidation in long-lived Myc hypomorphic mice. / 06.2019 / PubMed / Full text

SLC22A14

Explorative results from multistep screening for potential genetic risk loci of Alzheimer's disease in the longitudinal VITA study cohort. / 01.2018 / PubMed / Full text

SLC22A23

Clinical and genetic risk factors for decreased bone mineral density in Japanese patients with inflammatory bowel disease. / 11.2018 / PubMed / Full text

SLC24A5

[A question of colour]. / 01.2018 / PubMed / Full text

SLC26A2

Phenotypic characterization of Slc26a2 mutant mice reveals a multifactorial etiology of spondylolysis. / 01.2020 / PubMed / Full text

SLC2A4

Therapeutic and preventive effects of exercise on cardiometabolic parameters in aging and obese rats. / 02.2019 / PubMed / Full text

SLC30A1

Changes in Zn homeostasis during long term culture of primary endothelial cells and effects of Zn on endothelial cell senescence. / 01.12.2017 / PubMed / Full text

SLC30A10

Changes in Zn homeostasis during long term culture of primary endothelial cells and effects of Zn on endothelial cell senescence. / 01.12.2017 / PubMed / Full text

SLC30A5

Changes in Zn homeostasis during long term culture of primary endothelial cells and effects of Zn on endothelial cell senescence. / 01.12.2017 / PubMed / Full text

SLC39A6

Changes in Zn homeostasis during long term culture of primary endothelial cells and effects of Zn on endothelial cell senescence. / 01.12.2017 / PubMed / Full text

SLC41A1

Magnesium transporter protein solute carrier family 41 member 1 suppresses human pancreatic ductal adenocarcinoma through magnesium-dependent Akt/mTOR inhibition and bax-associated mitochondrial apoptosis. / 08.05.2019 / PubMed / Full text

SLC52A2

Clinical, pathological and functional characterization of riboflavin-responsive neuropathy. / 01.11.2017 / PubMed / Full text

SLC52A3

Clinical, pathological and functional characterization of riboflavin-responsive neuropathy. / 01.11.2017 / PubMed / Full text

SLC7A11

SOCS1 regulates senescence and ferroptosis by modulating the expression of p53 target genes. / 28.10.2017 / PubMed / Full text

SMAD1

TGFB1-Mediated Gliosis in Multiple Sclerosis Spinal Cords Is Favored by the Regionalized Expression of HOXA5 and the Age-Dependent Decline in Androgen Receptor Ligands. / 26.11.2019 / PubMed / Full text

SMARCA5

The epigenetic regulator SIRT7 guards against mammalian cellular senescence induced by ribosomal DNA instability. / 13.07.2018 / PubMed / Full text

SMARCB1

High-Throughput Functional Genetic and Compound Screens Identify Targets for Senescence Induction in Cancer. / 17.10.2017 / PubMed / Full text

SMARCD1

Delphinidin-3-glucoside suppresses lipid accumulation in HepG2 cells. / 12.2018 / PubMed / Full text

SMC2

The proteomic study of serially passaged human skin fibroblast cells uncovers down-regulation of the chromosome condensin complex proteins involved in replicative senescence. / 10.11.2018 / PubMed / Full text

SMC3

Effects of Heyan Kuntai Capsule () on Follicular Development and Oocyte Cohesin Levels in Aged Mice. / 10.2018 / PubMed / Full text

SMC4

The proteomic study of serially passaged human skin fibroblast cells uncovers down-regulation of the chromosome condensin complex proteins involved in replicative senescence. / 10.11.2018 / PubMed / Full text

SMN1

Changing respiratory expectations with the new disease trajectory of nusinersen treated spinal muscular atrophy [SMA] type 1. / 09.2018 / PubMed / Full text

SMN2

Age-dependent SMN expression in disease-relevant tissue and implications for SMA treatment. / 01.11.2019 / PubMed / Full text

SMO

Sonic hedgehog regulation of cavernous nerve regeneration and neurite formation in aged pelvic plexus. / 02.2019 / PubMed / Full text

SMOX

Skeletal Muscle Pathophysiology: The Emerging Role of Spermine Oxidase and Spermidine. / 14.02.2018 / PubMed / Full text

SMPD1

Alterations in Lipid Profile of the Aging Kidney Identified by MALDI Imaging Mass Spectrometry. / 05.07.2019 / PubMed / Full text

SMYD2

Collaboration of MYC and RUNX2 in lymphoma simulates T-cell receptor signaling and attenuates p53 pathway activity. / 10.2019 / PubMed / Full text

SNAI2

Reawakening of dormant estrogen-dependent human breast cancer cells by bone marrow stroma secretory senescence. / 17.08.2018 / PubMed / Full text

SND1

[Downregulation of SND1 Expression Accelerates Cell Senescence of Human Diploid Fibroblasts 2BS via Modulating the SASP]. / 05.2020 / PubMed / Full text

SOS1

Fucoidan⁻Fucoxanthin Ameliorated Cardiac Function via IRS1/GRB2/ SOS1, GSK3β/CREB Pathways and Metabolic Pathways in Senescent Mice. / 21.01.2019 / PubMed / Full text

SOX11

A lowered 26S proteasome activity correlates with mantle lymphoma cell lines resistance to genotoxic stress. / 10.08.2017 / PubMed / Full text

SOX13

In silico analysis of human renin gene-gene interactions and neighborhood topologically associated domains suggests breakdown of insulators contribute to ageing-associated diseases. / 12.2019 / PubMed / Full text

SOX4

Age-induced accumulation of methylmalonic acid promotes tumour progression. / 09.2020 / PubMed / Full text

SP1

Identification of key genes and transcription factors in aging mesenchymal stem cells by DNA microarray data. / 15.04.2019 / PubMed / Full text

SP2

Influence of season, age and management on scrotal thermal profile in Murrah bulls using scrotal infrared digital thermography. / 12.2017 / PubMed / Full text

SP7

microRNA-31 inhibition partially ameliorates the deficiency of bone marrow stromal cells from cleidocranial dysplasia. / 06.2019 / PubMed / Full text

SPATS2L

Longitudinal analysis of bronchodilator response in asthmatics and effect modification of age-related trends by genotype. / 02.2019 / PubMed / Full text

SPG7

Loss of the Drosophila m-AAA mitochondrial protease paraplegin results in mitochondrial dysfunction, shortened lifespan, and neuronal and muscular degeneration. / 21.02.2018 / PubMed / Full text

SPHK1

Sphingosine Kinase-1 Is Essential for Maintaining External/Outer Limiting Membrane and Associated Adherens Junctions in the Aging Retina. / 10.2019 / PubMed / Full text

SPHK2

Loss of genomic integrity induced by lysosphingolipid imbalance drives ageing in the heart. / 04.2019 / PubMed / Full text

SPON1

APOE influences working memory in non-demented elderly through an interaction with SPON1 rs2618516. / 07.2018 / PubMed / Full text

SPP1

Dehydroepiandrosterone enhances decidualization in women of advanced reproductive age. / 04.2018 / PubMed / Full text

SPRTN

Tandem Deubiquitination and Acetylation of SPRTN Promotes DNA-Protein Crosslink Repair and Protects against Aging. / 03.09.2020 / PubMed / Full text

SRD5A2

Extract of Plumbago zeylanica enhances the growth of hair follicle dermal papilla cells with down-regulation of 5α-reductase type II. / 11.2020 / PubMed / Full text

SRI

The Role of Aging, Drug Dependence, and Hepatitis C Comorbidity in Alcoholism Cortical Compromise. / 01.05.2018 / PubMed / Full text

SRL

Income dividends and subjective survival in a Cherokee Indian cohort: a quasi-experiment. / 04-06.2020 / PubMed / Full text

SRM

[Geriatric specificities of localized renal cell carcinoma]. / 11.2019 / PubMed / Full text

SRPK1

[Age-related changes in the content of serine-arginine protein kinase 1 (SRPK1) in human dermis.] / 2017 / PubMed

SRSF1

Cellular stress and AMPK activation as a common mechanism of action linking the effects of metformin and diverse compounds that alleviate accelerated aging defects in Hutchinson-Gilford progeria syndrome. / 09.2018 / PubMed / Full text

SRSF3

Alternative polyadenylation dependent function of splicing factor SRSF3 contributes to cellular senescence. / 04.03.2019 / PubMed / Full text

SRY

Identification of novel genes in aging osteoblasts using next-generation sequencing and bioinformatics. / 26.12.2017 / PubMed / Full text

SSBP2

Genetic associations with age of menopause in familial longevity. / 10.2019 / PubMed / Full text

ST18

[Target protein candidates of hypothalamus in aging rats with intervention by Qiongyugao]. / 04.2016 / PubMed / Full text

ST6GAL1

Glycobiology of Aging. / 2018 / PubMed / Full text

STC1

Proteomic profiling of follicle fluids after superstimulation in one-month-old lambs. / 02.2018 / PubMed / Full text

STC2

Genome-wide Associations Reveal Human-Mouse Genetic Convergence and Modifiers of Myogenesis, CPNE1 and STC2. / 05.12.2019 / PubMed / Full text

STK3

Dual functions for OVAAL in initiation of RAF/MEK/ERK prosurvival signals and evasion of p27-mediated cellular senescence. / 11.12.2018 / PubMed / Full text

STK32C

DNA methylation analysis on purified neurons and glia dissects age and Alzheimer's disease-specific changes in the human cortex. / 25.07.2018 / PubMed / Full text

STN1

CTC1-STN1 coordinates G- and C-strand synthesis to regulate telomere length. / 08.2018 / PubMed / Full text

STOML2

Slower Dynamics and Aged Mitochondria in Sporadic Alzheimer's Disease. / 2017 / PubMed / Full text

STX17

Directed elimination of senescent cells attenuates development of osteoarthritis by inhibition of c-IAP and XIAP. / 01.10.2019 / PubMed / Full text

SUCNR1

[The effect of Mexidol on cerebral mitochondriogenesis at a young age and during aging]. / 2020 / PubMed / Full text

SUGCT

Knockout of the non-essential gene SUGCT creates diet-linked, age-related microbiome disbalance with a diabetes-like metabolic syndrome phenotype. / 09.2020 / PubMed / Full text

SUMO1

SUMO1-conjugation is altered during normal aging but not by increased amyloid burden. / 08.2018 / PubMed / Full text

SUN1

Imbalanced nucleocytoskeletal connections create common polarity defects in progeria and physiological aging. / 26.02.2019 / PubMed / Full text

SUN2

Imbalanced nucleocytoskeletal connections create common polarity defects in progeria and physiological aging. / 26.02.2019 / PubMed / Full text

SURF1

Lifelong reduction in complex IV induces tissue-specific metabolic effects but does not reduce lifespan or healthspan in mice. / 08.2018 / PubMed / Full text

SUZ12

Epigallocatechin-3-gallate and BIX-01294 have different impact on epigenetics and senescence modulation in acute and chronic myeloid leukemia cells. / 05.11.2018 / PubMed / Full text

SV2B

Mutant Huntingtin Causes a Selective Decrease in the Expression of Synaptic Vesicle Protein 2C. / 10.2018 / PubMed / Full text

SV2C

Mutant Huntingtin Causes a Selective Decrease in the Expression of Synaptic Vesicle Protein 2C. / 10.2018 / PubMed / Full text

SYNE1

Nesprin-1 impact on tumorigenic cell phenotypes. / 02.2020 / PubMed / Full text

SYNJ1

Excess Synaptojanin 1 Contributes to Place Cell Dysfunction and Memory Deficits in the Aging Hippocampus in Three Types of Alzheimer's Disease. / 05.06.2018 / PubMed / Full text

SYNJ2

DNA methylation analysis on purified neurons and glia dissects age and Alzheimer's disease-specific changes in the human cortex. / 25.07.2018 / PubMed / Full text

SYP

The neuropeptide-12 improves recognition memory and neuronal plasticity of the limbic system in old rats. / 08.2018 / PubMed / Full text

SYT1

Two Behavioral Tests Allow a Better Correlation Between Cognitive Function and Expression of Synaptic Proteins. / 2018 / PubMed / Full text

SYT7

Synaptotagmin-7, a binding protein of P53, inhibits the senescence and promotes the tumorigenicity of lung cancer cells. / 28.02.2019 / PubMed / Full text

TAAR1

Minimal Age-Related Alterations in Behavioral and Hematological Parameters in Trace Amine-Associated Receptor 1 (TAAR1) Knockout Mice. / 03.2020 / PubMed / Full text

TAF7

Basonuclin 1 deficiency causes testicular premature aging: BNC1 cooperates with TAF7L to regulate spermatogenesis. / 22.01.2020 / PubMed / Full text

TAF7L

Basonuclin 1 deficiency causes testicular premature aging: BNC1 cooperates with TAF7L to regulate spermatogenesis. / 22.01.2020 / PubMed / Full text

TARDBP

Selective Spatiotemporal Vulnerability of Central Nervous System Neurons to Pathologic TAR DNA-Binding Protein 43 in Aged Transgenic Mice. / 06.2018 / PubMed / Full text

TAS1R2

Bitter, Sweet, Salty, Sour and Umami Taste Perception Decreases with Age: Sex-Specific Analysis, Modulation by Genetic Variants and Taste-Preference Associations in 18 to 80 Year-Old Subjects. / 18.10.2018 / PubMed / Full text

TBC1D1

Therapeutic and preventive effects of exercise on cardiometabolic parameters in aging and obese rats. / 02.2019 / PubMed / Full text

TCERG1

The longevity-promoting factor, TCER-1, widely represses stress resistance and innate immunity. / 17.07.2019 / PubMed / Full text

TCF15

Loss of Neurogenesis in Aging Hydra. / 05.2019 / PubMed / Full text

TCF21

Balance between senescence and apoptosis is regulated by telomere damage-induced association between p16 and caspase-3. / 22.06.2018 / PubMed / Full text

TCF7

Osteoprotection Through the Deletion of the Transcription Factor Rorβ in Mice. / 04.2018 / PubMed / Full text

TCTA

Exciplex-Forming Cohost for High Efficiency and High Stability Phosphorescent Organic Light-Emitting Diodes. / 17.01.2018 / PubMed / Full text

TDG

lncRNA H19 contributes to oxidative damage repair in the early age-related cataract by regulating miR-29a/TDG axis. / 09.2019 / PubMed / Full text

TDP1

UCHL3 Regulates Topoisomerase-Induced Chromosomal Break Repair by Controlling TDP1 Proteostasis. / 12.06.2018 / PubMed / Full text

TECPR2

Neuropathology-driven Whole-genome Sequencing Study Points to Novel Candidate Genes for Healthy Brain Aging. / 01-03.2019 / PubMed / Full text

TEF

Expression of human HSP27 in yeast extends replicative lifespan and uncovers a hormetic response. / 10.2020 / PubMed / Full text

TEP1

[Influence of Age on the Susceptibility of Anopheles stephensi to Plasmodium berghei Infection]. / 12.2016 / PubMed

TES

The Effects of Electrical Stimulation Pulse Duration on Lingual Palatal Pressure Measures During Swallowing in Healthy Older Adults. / 08.2019 / PubMed / Full text

TET3

Age-related Changes in the Global DNA Methylation Profile of Oligodendrocyte Progenitor Cells Derived from Rat Spinal Cords. / 02.2019 / PubMed / Full text

TFPI

Identification of cardiovascular health gene variants related to longevity in a Chinese population. / 07.09.2020 / PubMed / Full text

TGDS

The evaluation and design of a short depression screening tool in Turkish older adults. / 10.2018 / PubMed / Full text

TGFB1

Proteomic Alterations Associated with Biomechanical Dysfunction are Early Processes in the Emilin1 Deficient Mouse Model of Aortic Valve Disease. / 11.2017 / PubMed / Full text

TGFBR1

Dexamethasone Induces a Specific Form of Ramified Dysfunctional Microglia. / 02.2019 / PubMed / Full text

TGFBR2

TGF-β type 2 receptor-mediated modulation of the IL-36 family can be therapeutically targeted in osteoarthritis. / 08.05.2019 / PubMed / Full text

TGM2

Towards frailty biomarkers: Candidates from genes and pathways regulated in aging and age-related diseases. / 11.2018 / PubMed / Full text

THBS1

G protein-coupled receptor kinase 4-induced cellular senescence and its senescence-associated gene expression profiling. / 15.11.2017 / PubMed / Full text

THBS4

Specific factors in blood from young but not old mice directly promote synapse formation and NMDA-receptor recruitment. / 18.06.2019 / PubMed / Full text

THEMIS

Lifetime benefits of early detection and treatment of diabetic kidney disease. / 2019 / PubMed / Full text

THRB

Age-associated increase of thyroid hormone receptor β gene promoter methylation coexists with decreased gene expression. / 11.2018 / PubMed / Full text

TIMP2

The effects of aging, diabetes mellitus, and antiplatelet drugs on growth factors and anti-aging proteins in platelet-rich plasma. / 2019 / PubMed / Full text

TINF2

Acute telomerase components depletion triggers oxidative stress as an early event previous to telomeric shortening. / 04.2018 / PubMed / Full text

TJP1

Morphological and immunohistochemical characteristics of the equine corneal epithelium. / 11.2019 / PubMed / Full text

TLR3

Repetitive TLR3 activation in the lung induces skeletal muscle adaptations and cachexia. / 06.2018 / PubMed / Full text

TLR5

Neonatal selection by Toll-like receptor 5 influences long-term gut microbiota composition. / 08.2018 / PubMed / Full text

TLR6

Decreased NLRP3 inflammasome expression in aged lung may contribute to increased susceptibility to secondary Streptococcus pneumoniae infection. / 05.2018 / PubMed / Full text

TLR8

TLR8-Mediated Metabolic Control of Human Treg Function: A Mechanistic Target for Cancer Immunotherapy. / 08.01.2019 / PubMed / Full text

TMEM119

Dexamethasone Induces a Specific Form of Ramified Dysfunctional Microglia. / 02.2019 / PubMed / Full text

TNFSF15

Expression of pro- and anti-inflammatory cytokines and chemokines during the ovulatory cycle and effects of aging on their expression in the uterine mucosa of laying hens. / 11.2018 / PubMed / Full text

TNNI1

Regular aerobic exercise-ameliorated troponin I carbonylation to mitigate aged rat soleus muscle functional recession. / 05.2019 / PubMed / Full text

TNP1

Cytological and molecular aspects of the ageing sperm. / 01.02.2019 / PubMed / Full text

TNP2

Cytological and molecular aspects of the ageing sperm. / 01.02.2019 / PubMed / Full text

TNPO3

Genetic associations with age of menopause in familial longevity. / 10.2019 / PubMed / Full text

TOMM20

Effect of aging on mitochondria and metabolism of bovine granulosa cells. / 13.09.2020 / PubMed / Full text

TOP1

UCHL3 Regulates Topoisomerase-Induced Chromosomal Break Repair by Controlling TDP1 Proteostasis. / 12.06.2018 / PubMed / Full text

TOR2A

The correlation of copy number variations with longevity in a genome-wide association study of Han Chinese. / 05.06.2018 / PubMed / Full text

TP53INP1

TP53INP1 deficiency maintains murine B lymphopoiesis in aged bone marrow through redox-controlled IL-7R/STAT5 signaling. / 02.01.2019 / PubMed / Full text

TP53RK

Novel homozygous OSGEP gene pathogenic variants in two unrelated patients with Galloway-Mowat syndrome: case report and review of the literature. / 11.04.2019 / PubMed / Full text

TP73

G protein-coupled receptor kinase 4-induced cellular senescence and its senescence-associated gene expression profiling. / 15.11.2017 / PubMed / Full text

TPH1

[i]Lactobacillus plantarum[/i] DR7 improved brain health in aging rats via the serotonin, inflammatory and apoptosis pathways. / 02.12.2020 / PubMed / Full text

TPP1

FBW7 Mediates Senescence and Pulmonary Fibrosis through Telomere Uncapping. / 03.11.2020 / PubMed / Full text

TPRKB

Novel homozygous OSGEP gene pathogenic variants in two unrelated patients with Galloway-Mowat syndrome: case report and review of the literature. / 11.04.2019 / PubMed / Full text

TPX2

Targeting DTL induces cell cycle arrest and senescence and suppresses cell growth and colony formation through TPX2 inhibition in human hepatocellular carcinoma cells. / 2018 / PubMed / Full text

TRAF2

The Misshapen subfamily of Ste20 kinases regulate proliferation in the aging mammalian intestinal epithelium. / 12.2019 / PubMed / Full text

TRAP1

Lifelong Football Training: Effects on Autophagy and Healthy Longevity Promotion. / 2019 / PubMed / Full text

TRAV1-2

Human blood MAIT cell subsets defined using MR1 tetramers. / 05.2018 / PubMed / Full text

TRAV27

Perturbed CD8 T cell immunity across universal influenza epitopes in the elderly. / 02.2018 / PubMed / Full text

TRBV19

Perturbed CD8 T cell immunity across universal influenza epitopes in the elderly. / 02.2018 / PubMed / Full text

TRIB2

TRIB2 functions as novel oncogene in colorectal cancer by blocking cellular senescence through AP4/p21 signaling. / 12.12.2018 / PubMed / Full text

TRIB3

Inhibition of glioma growth by flavokawain B is mediated through endoplasmic reticulum stress induced autophagy. / 2018 / PubMed / Full text

TRIM21

TRIM21 overexpression promotes tumor progression by regulating cell proliferation, cell migration and cell senescence in human glioma. / 2020 / PubMed / Full text

TRIM27

TRIM27 Functions as a Novel Oncogene in Non-Triple-Negative Breast Cancer by Blocking Cellular Senescence through p21 Ubiquitination. / 04.12.2020 / PubMed / Full text

TRIM28

Depleting Trim28 in adult mice is well tolerated and reduces levels of α-synuclein and tau. / 04.06.2018 / PubMed / Full text

TRIP13

BubR1 allelic effects drive phenotypic heterogeneity in mosaic-variegated aneuploidy progeria syndrome. / 02.01.2020 / PubMed / Full text

TRPC1

Ca entry via TRPC1 is essential for cellular differentiation and modulates secretion via the SNARE complex. / 01.07.2019 / PubMed / Full text

TRPC7

Nociceptive transient receptor potential canonical 7 (TRPC7) mediates aging-associated tumorigenesis induced by ultraviolet B. / 01.2020 / PubMed / Full text

TRPM6

Role of kinase-coupled TRP channels in mineral homeostasis. / 04.2018 / PubMed / Full text

TRPS1

miRNA expression profiling uncovers a role of miR-302b-3p in regulating skin fibroblasts senescence. / 01.2020 / PubMed / Full text

TRPV5

Changes in expression of klotho affect physiological processes, diseases, and cancer. / 01.2018 / PubMed / Full text

TRPV6

Changes in expression of klotho affect physiological processes, diseases, and cancer. / 01.2018 / PubMed / Full text

TSG101

Exosomal Notch3 from high glucose-stimulated endothelial cells regulates vascular smooth muscle cells calcification/aging. / 01.09.2019 / PubMed / Full text

TSHB

Adipose TSHB in Humans and Serum TSH in Hypothyroid Rats Inform About Cellular Senescence. / 2018 / PubMed / Full text

TSHR

TSH-independent release of thyroid hormones through cold exposure in aging rats. / 27.10.2017 / PubMed / Full text

TSPYL5

Uncovering genetic mechanisms of kidney aging through transcriptomics, genomics, and epigenomics. / 03.2019 / PubMed / Full text

TTL

Longitudinal Associations of Body Mass Index, Waist Circumference, and Waist-to-Hip Ratio with Biomarkers of Oxidative Stress in Older Adults: Results of a Large Cohort Study. / 2020 / PubMed / Full text

TXN

Thioredoxin mitigates radiation-induced hematopoietic stem cell injury in mice. / 15.11.2017 / PubMed / Full text

TXNDC5

Genetic associations with age of menopause in familial longevity. / 10.2019 / PubMed / Full text

TXNRD1

The genetic component of human longevity: New insights from the analysis of pathway-based SNP-SNP interactions. / 06.2018 / PubMed / Full text

TYK2

Immunologic effects of chronic administration of tofacitinib, a Janus kinase inhibitor, in cynomolgus monkeys and rats - Comparison of juvenile and adult responses. / 04.2018 / PubMed / Full text

TYROBP

TREM2 triggers microglial density and age-related neuronal loss. / 03.2019 / PubMed / Full text

U2AF1

Isobaric tags for relative and absolute quantitation (iTRAQ)-based proteomic analysis of mRNA splicing relevant proteins in aging HSPCs. / 05.03.2020 / PubMed / Full text

UACA

Knockdown of [i]UACA[/i] inhibitsproliferation and invasion and promotes senescence of hepatocellular carcinoma cells. / 2018 / PubMed / Full text

UBB

Different Expression Levels of Human Mutant Ubiquitin B (UBB ) Can Modify Chronological Lifespan or Stress Resistance of [i]Saccharomyces cerevisiae[/i]. / 2018 / PubMed / Full text

UBC

Selection of a Real-Time PCR Housekeeping Gene Panel in Human Endothelial Colony Forming Cells for Cellular Senescence Studies. / 2019 / PubMed / Full text

UBE2E3

Loss of the ubiquitin conjugating enzyme UBE2E3 induces cellular senescence. / 07.2018 / PubMed / Full text

UBE3A

Delayed loss of UBE3A reduces the expression of Angelman syndrome-associated phenotypes. / 2019 / PubMed / Full text

UBE4B

CircRNAs in the tree shrew ([i]Tupaia belangeri[/i]) brain during postnatal development and aging. / 30.04.2018 / PubMed / Full text

UBTF

Age-associated dysregulation of protein metabolism in the mammalian oocyte. / 12.2017 / PubMed / Full text

UCHL1

Abolishing UCHL1's hydrolase activity exacerbates TBI-induced axonal injury and neuronal death in mice. / 04.11.2020 / PubMed / Full text

UCHL3

UCHL3 Regulates Topoisomerase-Induced Chromosomal Break Repair by Controlling TDP1 Proteostasis. / 12.06.2018 / PubMed / Full text

UCN

Novel molecular mechanisms for the adaptogenic effects of herbal extracts on isolated brain cells using systems biology. / 15.11.2018 / PubMed / Full text

UCN3

Urocortin 3 signalling in the auditory brainstem aids recovery of hearing after reversible noise-induced threshold shift. / 08.2019 / PubMed / Full text

UCP3

Integrated study on comparative transcriptome and skeletal muscle function in aged rats. / 01.2018 / PubMed / Full text

UGT2B28

Ages of hepatocellular carcinoma occurrence and life expectancy are associated with a UGT2B28 genomic variation. / 05.12.2019 / PubMed / Full text

UGT2B7

Application of a physiologically based pharmacokinetic model for the prediction of mirabegron plasma concentrations in a population with severe renal impairment. / 05.2019 / PubMed / Full text

UHRF1

MLL3 promotes the senescence of esophageal squamous cell carcinoma. / 2019 / PubMed / Full text

ULK2

miR-26a suppresses autophagy in swine Sertoli cells by targeting ULK2. / 08.2018 / PubMed / Full text

UMOD

The relationships between markers of tubular injury and intrarenal haemodynamic function in adults with and without type 1 diabetes: Results from the Canadian Study of Longevity in Type 1 Diabetes. / 03.2019 / PubMed / Full text

UNG

UNG-1 and APN-1 are the major enzymes to efficiently repair 5-hydroxymethyluracil DNA lesions in C. elegans. / 01.05.2018 / PubMed / Full text

UPF1

Differential alternative splicing coupled to nonsense-mediated decay of mRNA ensures dietary restriction-induced longevity. / 21.08.2017 / PubMed / Full text

UQCRC2

Elucidation of the mechanism of changes in the antioxidant function with the aging in the liver of the senescence-accelerated mouse P10 (SAMP10). / 06.2018 / PubMed / Full text

USF1

The rs2516839 variation of USF1 gene is associated with 4-year mortality of nonagenarian women: The Vitality 90+ study. / 01.2019 / PubMed / Full text

USF2

Age-Related Expression of Human AT1R Variants and Associated Renal Dysfunction in Transgenic Mice. / 15.10.2018 / PubMed / Full text

USP14

Low expression of aging-related [[NRXN3]] is associated with Alzheimer disease: A systematic review and meta-analysis. / 07.2018 / PubMed / Full text

USP15

Deficiency of parkin and PINK1 impairs age-dependent mitophagy in [i]Drosophila[/i]. / 29.05.2018 / PubMed / Full text

USP28

Genetic interrogation of replicative senescence uncovers a dual role for USP28 in coordinating the p53 and GATA4 branches of the senescence program. / 01.10.2017 / PubMed / Full text

USP30

Deficiency of parkin and PINK1 impairs age-dependent mitophagy in [i]Drosophila[/i]. / 29.05.2018 / PubMed / Full text

USP7

Deubiquitinase USP7 regulates [i]Drosophila[/i] aging through ubiquitination and autophagy. / 20.11.2020 / PubMed / Full text

USP8

Inhibition of the deubiquitinase USP8 corrects a Drosophila PINK1 model of mitochondria dysfunction. / 04.2019 / PubMed / Full text

VAMP2

Newly produced synaptic vesicle proteins are preferentially used in synaptic transmission. / 01.08.2018 / PubMed / Full text

VAMP8

NUPR1 maintains autolysosomal efflux by activating SNAP25 transcription in cancer cells. / 2018 / PubMed / Full text

VASH1

Double-Face of Vasohibin-1 for the Maintenance of Vascular Homeostasis and Healthy Longevity. / 01.06.2018 / PubMed / Full text

VASP

Reversal of Aging-Induced Increases in Aortic Stiffness by Targeting Cytoskeletal Protein-Protein Interfaces. / 18.07.2018 / PubMed / Full text

VCL

The effects of different preservation methods on ide (Leuciscus idus) sperm and the longevity of sperm movement. / 04.2018 / PubMed / Full text

VCP

The role of air pollution and lung function in cognitive impairment. / 02.2018 / PubMed / Full text

VEGFA

APOE ε4-specific associations of VEGF gene family expression with cognitive aging and Alzheimer's disease. / 03.2020 / PubMed / Full text

VEGFC

Proteomic profiling of follicle fluids after superstimulation in one-month-old lambs. / 02.2018 / PubMed / Full text

VEGFD

Single-Arm Resistance Training Study to Determine the Relationship between Training Outcomes and Muscle Growth Factor mRNAs in Older Adults Consuming Numerous Medications and Supplements. / 2018 / PubMed / Full text

VGLL4

The lncRNA MEG3/miR-16-5p/VGLL4 regulatory axis is involved in etoposide-induced senescence of tumor cells. / 03.11.2020 / PubMed / Full text

VHLL

The Monetary Valuation of Lifetime Health Improvement and Life Expectancy Gains in Turkey. / 29.09.2017 / PubMed / Full text

VIPR2

Novel molecular mechanisms for the adaptogenic effects of herbal extracts on isolated brain cells using systems biology. / 15.11.2018 / PubMed / Full text

VPREB3

Age-related but not longevity-related genes are found by weighted gene co-expression network analysis in the peripheral blood cells of humans. / 19.01.2019 / PubMed / Full text

VPS13C

SerThr-PhosphoProteome of Brain from Aged PINK1-KO+A53T-SNCA Mice Reveals pT1928-MAP1B and pS3781-ANK2 Deficits, as Hub between Autophagy and Synapse Changes. / 04.07.2019 / PubMed / Full text

VPS13D

SerThr-PhosphoProteome of Brain from Aged PINK1-KO+A53T-SNCA Mice Reveals pT1928-MAP1B and pS3781-ANK2 Deficits, as Hub between Autophagy and Synapse Changes. / 04.07.2019 / PubMed / Full text

VPS29

Combined Proteomic and Metabolomic Profiling of the [i]Arabidopsis thaliana vps29[/i] Mutant Reveals Pleiotropic Functions of the Retromer in Seed Development. / 16.01.2019 / PubMed / Full text

VPS35

Combined Proteomic and Metabolomic Profiling of the [i]Arabidopsis thaliana vps29[/i] Mutant Reveals Pleiotropic Functions of the Retromer in Seed Development. / 16.01.2019 / PubMed / Full text

VSIG4

Immune checkpoint protein VSIG4 as a biomarker of aging in murine adipose tissue. / 10.2020 / PubMed / Full text

WAS

Psychological stress exposure to aged mice causes abnormal feeding patterns with changes in the bout number. / 09.11.2017 / PubMed / Full text

WASL

Loss of Wasl improves pancreatic cancer outcome. / 21.05.2020 / PubMed / Full text

WDR5

Inhibition of the H3K4 methyltransferase MLL1/WDR5 complex attenuates renal senescence in ischemia reperfusion mice by reduction of p16 . / 11.2019 / PubMed / Full text

WDR73

Novel homozygous OSGEP gene pathogenic variants in two unrelated patients with Galloway-Mowat syndrome: case report and review of the literature. / 11.04.2019 / PubMed / Full text

WFDC2

Differences in biomarkers and molecular pathways according to age for patients with HFrEF. / 01.10.2020 / PubMed / Full text

WFIKKN1

Relationship of Circulating Growth and Differentiation Factors 8 and 11 and Their Antagonists as Measured Using Liquid Chromatography-Tandem Mass Spectrometry With Age and Skeletal Muscle Strength in Healthy Adults. / 01.01.2019 / PubMed / Full text

WFIKKN2

Relationship of Circulating Growth and Differentiation Factors 8 and 11 and Their Antagonists as Measured Using Liquid Chromatography-Tandem Mass Spectrometry With Age and Skeletal Muscle Strength in Healthy Adults. / 01.01.2019 / PubMed / Full text

WLS

Evaluation of three statistical prediction models for forensic age prediction based on DNA methylation. / 05.2018 / PubMed / Full text

WNK1

Overexpression of WNK1 in POMC-expressing neurons reduces weigh gain via WNK4-mediated degradation of Kir6.2. / 10.2018 / PubMed / Full text

WNK4

Overexpression of WNK1 in POMC-expressing neurons reduces weigh gain via WNK4-mediated degradation of Kir6.2. / 10.2018 / PubMed / Full text

WNT10A

Dysregulation of the Wnt Signaling Pathway and Synovial Stem Cell Dysfunction in Osteoarthritis Development. / 01.04.2020 / PubMed / Full text

WNT16

Inducible [i]Wnt16[/i] inactivation: WNT16 regulates cortical bone thickness in adult mice. / 05.2018 / PubMed / Full text

WNT3

Role of CD133 Molecule in Wnt Response and Renal Repair. / 03.2018 / PubMed / Full text

WNT5A

WNT5A supports viability of senescent human dental follicle cells. / 05.2019 / PubMed / Full text

WNT7A

Exogenous Expression of WNT7A in Leukemia-Derived Cell Lines Induces Resistance to Chemotherapeutic Agents. / 2020 / PubMed / Full text

WT1

Age and weight at first mating affects plasma leptin concentration but no effects on reproductive performance of gilts. / 09.2019 / PubMed / Full text

WWP1

The ubiquitin ligase WWP1 contributes to shifts in matrix proteolytic profiles and a myocardial aging phenotype with diastolic heart. / 01.10.2020 / PubMed / Full text

XDH

Enhancing xanthine dehydrogenase activity is an effective way to delay leaf senescence and increase rice yield. / 11.03.2020 / PubMed / Full text

XG

The effect of administration media on palatability and ease of swallowing of multiparticulate formulations. / 15.11.2018 / PubMed / Full text

XPC

MicroRNA binding mediated Functional sequence variant in 3'-UTR of DNA repair Gene XPC in Age-related Cataract. / 12.10.2018 / PubMed / Full text

XPO1

Nuclear Export Inhibition Enhances HLH-30/TFEB Activity, Autophagy, and Lifespan. / 15.05.2018 / PubMed / Full text

XRCC4

The replicative senescent mesenchymal stem / stromal cells defect in DNA damage response and anti-oxidative capacity. / 2018 / PubMed / Full text

YES1

Re-exploring the core genes and modules in the human frontal cortex during chronological aging: insights from network-based analysis of transcriptomic studies. / 20.10.2018 / PubMed / Full text

ZBTB16

miR-19b-3p induces cell proliferation and reduces heterochromatin-mediated senescence through PLZF in goat male germline stem cells. / 06.2018 / PubMed / Full text

ZFHX3

Shift work, DNA methylation and epigenetic age. / 01.10.2019 / PubMed / Full text

ZFPM2

Novel molecular mechanisms for the adaptogenic effects of herbal extracts on isolated brain cells using systems biology. / 15.11.2018 / PubMed / Full text

ZNF207

Proteomics and metabolomics identify molecular mechanisms of aging potentially predisposing for chronic lymphocytic leukemia. / 02.2018 / PubMed / Full text

ZNF396

Novel molecular mechanisms for the adaptogenic effects of herbal extracts on isolated brain cells using systems biology. / 15.11.2018 / PubMed / Full text

ZNF467

Novel molecular mechanisms for the adaptogenic effects of herbal extracts on isolated brain cells using systems biology. / 15.11.2018 / PubMed / Full text

ZNF521

Reduced subcutaneous adipogenesis in human hypertrophic obesity is linked to senescent precursor cells. / 21.06.2019 / PubMed / Full text