Aging genes 1-2
SOCS1
ATG9A
LAT2
- Blood glucose, amino acid profiles and nutrient transporter gene expressions in the small intestine of low and normal birthweight piglets during the early suckling period. / 05.2019 / PubMed / Full text
- Skeletal muscle: from birth to old age, routes to mechanical and metabolic failure. / 2017 / PubMed / Full text
ID1
OAT
- Opioid agonist treatment reduces losses in quality of life and quality-adjusted life expectancy in heroin users: Evidence from real world data. / 01.08.2019 / PubMed / Full text
- Strength training and aerobic exercise alter mitochondrial parameters in brown adipose tissue and equally reduce body adiposity in aged rats. / 02.2019 / PubMed / Full text
ERBB2
NDNF
- Effect of neuron-derived neurotrophic factor on rejuvenation of human adipose-derived stem cells for cardiac repair after myocardial infarction. / 09.2019 / PubMed / Full text
- Aged Human Multipotent Mesenchymal Stromal Cells Can Be Rejuvenated by Neuron-Derived Neurotrophic Factor and Improve Heart Function After Injury. / 12.2017 / PubMed / Full text
NECTIN2
NDUFB8
- Effect of Melatonin on Rat Heart Mitochondria in Acute Heart Failure in Aged Rats. / 23.05.2018 / PubMed / Full text
- Maternal nutrient restriction in baboon programs later-life cellular growth and respiration of cultured skin fibroblasts: a potential model for the study of aging-programming interactions. / 06.2018 / PubMed / Full text
HSF2
- Identification of key genes and transcription factors in aging mesenchymal stem cells by DNA microarray data. / 15.04.2019 / PubMed / Full text
- Nutrition and water temperature regulate the expression of heat-shock proteins in golden pompano larvae (Trachinotus ovata, Limmaeus 1758). / 04.2019 / PubMed / Full text
IQGAP1
PAK1
- 1,2,3-Triazolyl ester of ketorolac (15K): Boosting both heat-endurance and lifespan of C. elegans by down-regulating PAK1 at nM levels. / 2018 / PubMed / Full text
- From bench (laboratory) to bed (hospital/home): How to explore effective natural and synthetic PAK1-blockers/longevity-promoters for cancer therapy. / 15.12.2017 / PubMed / Full text
GNRH1
SORL1
CISD2
- CISD2 Attenuates Inflammation and Regulates Microglia Polarization in EOC Microglial Cells-As a Potential Therapeutic Target for Neurodegenerative Dementia. / 2020 / PubMed / Full text
- Protective Effects of CISD2 and Influence of Curcumin on CISD2 Expression in Aged Animals and Inflammatory Cell Model. / 25.03.2019 / PubMed / Full text
MAPKAPK2
RPS6
NNMT
- Small molecule nicotinamide N-methyltransferase inhibitor activates senescent muscle stem cells and improves regenerative capacity of aged skeletal muscle. / 05.2019 / PubMed / Full text
- Nicotinamide-N-methyltransferase controls behavior, neurodegeneration and lifespan by regulating neuronal autophagy. / 09.2018 / PubMed / Full text
SPARCL1
IRF7
- Transcriptome analysis reveals immune-related gene expression changes with age in giant panda ([i]Ailuropoda melanoleuca[/i]) blood. / 14.01.2019 / PubMed / Full text
- Sirtuin 1-Chromatin-Binding Dynamics Points to a Common Mechanism Regulating Inflammatory Targets in SIV Infection and in the Aging Brain. / 06.2018 / PubMed / Full text
RGN
- Effect of senescence marker protein 30 on the proliferation and apoptosis of human lens epithelial cells SRA01/04. / 2018 / PubMed / Full text
- Effect of supplementation of recombinant Regucalcin in extender on cryopreservation of spermatozoa of water buffalo (Bubalus bubalis). / 11.2017 / PubMed / Full text
MCM7
AQP1
EN1
PPID
- Relationships of inflamm-aging with circulating nutrient levels, body composition, age, and pituitary pars intermedia dysfunction in a senior horse population. / 03.2020 / PubMed / Full text
- Epidemiology of pituitary pars intermedia dysfunction: A systematic literature review of clinical presentation, disease prevalence and risk factors. / 05.2018 / PubMed / Full text
ADH5
LTB
- Aging and Hyperglycemia Intensify Dyslipidemia-Induced Oxidative Stress and Inflammation in Rats: Assessment of Restorative Potentials of ALA and EPA + DHA. / 06.2019 / PubMed / Full text
- Advanced age in mares affects endometrial secretion of arachidonic acid metabolites during equine subclinical endometritis. / 11.2017 / PubMed / Full text
TRH
GLS
CLC
RAG1
HLA-C
- Epigenome-wide exploratory study of monozygotic twins suggests differentially methylated regions to associate with hand grip strength. / 10.2019 / PubMed / Full text
- Cytomegalovirus-Specific T Cells Restricted by HLA-Cw*0702 Increase Markedly with Age and Dominate the CD8 T-Cell Repertoire in Older People. / 2017 / PubMed / Full text
WFS1
- Knockdown of wfs1, a fly homolog of Wolfram syndrome 1, in the nervous system increases susceptibility to age- and stress-induced neuronal dysfunction and degeneration in Drosophila. / 01.2018 / PubMed / Full text
- A nonsynonymous mutation in the WFS1 gene in a Finnish family with age-related hearing impairment. / 11.2017 / PubMed / Full text
PLIN2
- Cardiac overexpression of perilipin 2 induces atrial steatosis, connexin 43 remodeling, and atrial fibrillation in aged mice. / 01.12.2019 / PubMed / Full text
- HDAC6 Suppresses Age-Dependent Ectopic Fat Accumulation by Maintaining the Proteostasis of PLIN2 in Drosophila. / 09.10.2017 / PubMed / Full text
CCL24
- Regulatory T-cells regulate neonatal heart regeneration by potentiating cardiomyocyte proliferation in a paracrine manner. / 2019 / PubMed / Full text
- Anserine/Carnosine Supplementation Suppresses the Expression of the Inflammatory Chemokine CCL24 in Peripheral Blood Mononuclear Cells from Elderly People. / 31.10.2017 / PubMed / Full text
TAS2R16
B4GALT1
FGFR4
NAV2
ANK1
- Alzheimer's Disease Associated Genes Ankyrin and Tau Cause Shortened Lifespan and Memory Loss in [i]Drosophila[/i]. / 2019 / PubMed / Full text
- DNA methylation analysis on purified neurons and glia dissects age and Alzheimer's disease-specific changes in the human cortex. / 25.07.2018 / PubMed / Full text
COL3A1
- Different expression of Defensin-B gene in the endometrium of mares of different age during the breeding season. / 21.12.2019 / PubMed / Full text
- Reductive Stress Selectively Disrupts Collagen Homeostasis and Modifies Growth Factor-independent Signaling Through the MAPK/Akt Pathway in Human Dermal Fibroblasts. / 06.2019 / PubMed / Full text
ATP7A
TPO
HAS1
TIMELESS
PROC
- Does midlife aging impact women's sleep duration, continuity, and timing?: A longitudinal analysis from the Study of Women's Health Across the Nation. / 15.04.2020 / PubMed / Full text
- Effects of feeding frequency of an elevated plane of milk replacer and calf age on behavior, and glucose and insulin kinetics in male Holstein calves. / 07.2019 / PubMed / Full text
FLT1
IGFBP1
NLRC4
PTBP1
- Dual functions for OVAAL in initiation of RAF/MEK/ERK prosurvival signals and evasion of p27-mediated cellular senescence. / 11.12.2018 / PubMed / Full text
- PTBP1-Mediated Alternative Splicing Regulates the Inflammatory Secretome and the Pro-tumorigenic Effects of Senescent Cells. / 09.07.2018 / PubMed / Full text
LSR
MLH1
DISC1
RAN
SRR
MIF
GSTA4
MCM2
RNF8
NOTCH3
AGO2
LATS2
CTLA4
- Horticultural Therapy Reduces Biomarkers of Immunosenescence and Inflammaging in Community-Dwelling Older Adults: A Feasibility Pilot Randomized Controlled Trial. / 18.10.2020 / PubMed / Full text
- [Efficacy and toxicity of immune checkpoint inhibitors in elderly patients - 5th edition of the congress of pharmacology of anticancer drugs]. / 12.2018 / PubMed / Full text
SESN2
- Copy Number Alterations in Papillary Thyroid Carcinomas: Does Loss of [i]SESN2[/i] Have a Role in Age-related Different Prognoses? / 09-10.2020 / PubMed / Full text
- Loss of sestrin 2 potentiates the early onset of age-related sensory cell degeneration in the cochlea. / 11.10.2017 / PubMed / Full text
ZEB1
CLPP
- Mitochondrial unfolded protein response: a stress response with implications for fertility and reproductive aging. / 02.2019 / PubMed / Full text
- Mitochondrial unfolded protein response gene Clpp is required to maintain ovarian follicular reserve during aging, for oocyte competence, and development of pre-implantation embryos. / 08.2018 / PubMed / Full text
BNIP3
- Late life maintenance and enhancement of functional exercise capacity in low and high responding rats after low intensity treadmill training. / 01.10.2019 / PubMed / Full text
- Regulation of apoptosis and autophagy in mouse and human skeletal muscle with aging and lifelong exercise training. / 01.10.2018 / PubMed / Full text
CSRP1
BCL6
GRK5
MCL1
COPE
L1CAM
MMP3
INSL3
- Effect of Thyroxine Replacement on Leydig Cell and Sertoli Cell Function in Men with Hypothyroidism. / 05-06.2020 / PubMed / Full text
- Age related and seasonal changes of plasma concentrations of insulin-like peptide 3 and testosterone from birth to early-puberty in Thoroughbred male horses. / 01.07.2019 / PubMed / Full text
CYP1A1
- Genome-wide scan identified genetic variants associated with skin aging in a Chinese female population. / 10.2019 / PubMed / Full text
- Furanoflavones pongapin and lanceolatin B blocks the cell cycle and induce senescence in CYP1A1-overexpressing breast cancer cells. / 15.12.2018 / PubMed / Full text
POSTN
HLA-B
- Epigenome-wide exploratory study of monozygotic twins suggests differentially methylated regions to associate with hand grip strength. / 10.2019 / PubMed / Full text
- Cytomegalovirus-Specific T Cells Restricted by HLA-Cw*0702 Increase Markedly with Age and Dominate the CD8 T-Cell Repertoire in Older People. / 2017 / PubMed / Full text
IRF4
PLD2
IDE
- Dendrobium nobile Lindl. Alkaloids Ameliorate Cognitive Dysfunction in Senescence Accelerated SAMP8 Mice by Decreasing Amyloid-β Aggregation and Enhancing Autophagy Activity. / 2020 / PubMed / Full text
- Hyperinsulinemia is associated with increasing insulin secretion but not with decreasing insulin clearance in an age-related metabolic dysfunction mice model. / 06.2019 / PubMed / Full text
NPR1
- The NPR1-WRKY46-WRKY6 signaling cascade mediates probenazole/salicylic acid-elicited leaf senescence in Arabidopsis thaliana. / 03.12.2020 / PubMed / Full text
- Loss of proton/calcium exchange 1 results in the activation of plant defense and accelerated senescence in Arabidopsis. / 07.2020 / PubMed / Full text
CYP2D6
- Application of a physiologically based pharmacokinetic model for the prediction of mirabegron plasma concentrations in a population with severe renal impairment. / 05.2019 / PubMed / Full text
- [Use of Pharmacogenetic Information for Therapeutic Drug Monitoring of an Antiarrhythmic Drug]. / 2018 / PubMed / Full text
PAPPA
ZC3H12A
NMNAT2
BMF
ACAT1
- An Adult Drosophila Glioma Model for Studying Pathometabolic Pathways of Gliomagenesis. / 06.2019 / PubMed / Full text
- Serum starvation of ARPE-19 changes the cellular distribution of cholesterol and Fibulin3 in patterns reminiscent of age-related macular degeneration. / 15.12.2017 / PubMed / Full text
CYLD
POT1
CPQ
NRK
- [Molecular mechanisms of mycelium of Cordyceps sinensis ameliorating renal tubular epithelial cells aging induced by D-galactose via inhibiting autophagy-related AMPK/ULK1 signaling activation]. / 03.2019 / PubMed / Full text
- Hyperoside attenuates renal aging and injury induced by D-galactose via inhibiting AMPK-ULK1 signaling-mediated autophagy. / 24.12.2018 / PubMed / Full text
CCL20
- p53 and p53-related mediators PAI-1 and IGFBP-3 are downregulated in peripheral blood mononuclear cells of HIV-patients exposed to non-nucleoside reverse transcriptase inhibitors. / 06.2020 / PubMed / Full text
- Effects of the Consumption of Milk Biofortified with Selenium, Vitamin E, and Different Fatty Acid Profile on Immune Response in the Elderly. / 02.2018 / PubMed / Full text
YAP1
CYP1A2
- Impact of Ethnicity-Specific Hepatic Microsomal Scaling Factor, Liver Weight, and Cytochrome P450 (CYP) 1A2 Content on Physiologically Based Prediction of CYP1A2-Mediated Pharmacokinetics in Young and Elderly Chinese Adults. / 07.2019 / PubMed / Full text
- Pediatric Cytochrome P450 Activity Alterations in Nonalcoholic Steatohepatitis. / 12.2017 / PubMed / Full text
ARID1A
CPD
CYP27B1
FHL2
LRP5
CFD
CHI3L1
FOXA1
- Analyses of an epigenetic switch involved in the activation of pioneer factor FOXA1 leading to the prognostic value of estrogen receptor and FOXA1 co-expression in breast cancer. / 28.09.2019 / PubMed / Full text
- The correlation of copy number variations with longevity in a genome-wide association study of Han Chinese. / 05.06.2018 / PubMed / Full text
CCL17
- Aging and chronic high-fat feeding negatively affects kidney size, function, and gene expression in CTRP1-deficient mice. / 21.10.2020 / PubMed / Full text
- Senescent thyrocytes and thyroid tumor cells induce M2-like macrophage polarization of human monocytes via a PGE2-dependent mechanism. / 21.05.2019 / PubMed / Full text
SSB
- Modelling the Effects of Beverage Substitution during Adolescence on Later Obesity Outcomes in Early Adulthood: Results from the Raine Study. / 03.12.2019 / PubMed / Full text
- WHIRLY1 Occupancy Affects Histone Lysine Modification and [i]WRKY53[/i] Transcription in [i]Arabidopsis[/i] Developmental Manner. / 2018 / PubMed / Full text
HGD
SMAD2
LRP4
DDX58
HAL
- Comparison of haloperidol, non-haloperidol antipsychotics, and no pharmacotherapy for the management of delirium in an inpatient geriatric palliative care population. / 06-09.2018 / PubMed / Full text
- Acute and long-term effects of haloperidol on surgery-induced neuroinflammation and cognitive deficits in aged rats. / 06.2019 / PubMed / Full text
FAAH
FABP4
- Senescence Alters PPARγ (Peroxisome Proliferator-Activated Receptor Gamma)-Dependent Fatty Acid Handling in Human Adipose Tissue Microvascular Endothelial Cells and Favors Inflammation. / 05.2018 / PubMed / Full text
- Endothelial APLNR regulates tissue fatty acid uptake and is essential for apelin's glucose-lowering effects. / 13.09.2017 / PubMed / Full text
TREX1
MAP1LC3B
PYY
MAPK14
- Micro-RNAS Regulate Metabolic Syndrome-induced Senescence in Porcine Adipose Tissue-derived Mesenchymal Stem Cells through the P16/MAPK Pathway. / 10.2018 / PubMed / Full text
- G protein-coupled receptor kinase 4-induced cellular senescence and its senescence-associated gene expression profiling. / 15.11.2017 / PubMed / Full text
NCL
ACACA
- Expression of lipogenic markers is decreased in subcutaneous adipose tissue and adipocytes of older women and is negatively linked to GDF15 expression. / 08.2019 / PubMed / Full text
- GH prevents adipogenic differentiation of mesenchymal stromal stem cells derived from human trabecular bone via canonical Wnt signaling. / 07.2018 / PubMed / Full text
ATG3
AREG
- Targeting amphiregulin (AREG) derived from senescent stromal cells diminishes cancer resistance and averts programmed cell death 1 ligand (PD-L1)-mediated immunosuppression. / 12.2019 / PubMed / Full text
- Regulatory T-cells regulate neonatal heart regeneration by potentiating cardiomyocyte proliferation in a paracrine manner. / 2019 / PubMed / Full text
PTPN11
- Fine mapping genetic variants associated with age at puberty and sow fertility using SowPro90 genotyping array. / 01.10.2020 / PubMed / Full text
- A tyrosine kinase-activating variant Asn666Ser in PDGFRB causes a progeria-like condition in the severe end of Penttinen syndrome. / 04.2019 / PubMed / Full text
NOP10
- Pseudouridylation defect due to [i]DKC1[/i] and [i]NOP10[/i] mutations causes nephrotic syndrome with cataracts, hearing impairment, and enterocolitis. / 30.06.2020 / PubMed / Full text
- Acute telomerase components depletion triggers oxidative stress as an early event previous to telomeric shortening. / 04.2018 / PubMed / Full text
MTM1
IDS
SV2A
NMNAT1
VCAM1
NOS2
SCAP
- Dementia outcomes after addition of proxy-based assessments for deceased or proxy-dependent participants. / 10.2019 / PubMed / Full text
- Increased hepatic INSIG-SCAP-SREBP expression is associated with cholesterol metabolism disorder in assisted reproductive technology-conceived aged mice. / 03.2019 / PubMed / Full text
AGER
PDC
- The mitochondrial translocase of the inner membrane PaTim54 is involved in defense response and longevity in Podospora anserina. / 11.2019 / PubMed / Full text
- Neuron-specific knockdown of Drosophila PDHB induces reduction of lifespan, deficient locomotive ability, abnormal morphology of motor neuron terminals and photoreceptor axon targeting. / 15.05.2018 / PubMed / Full text
SLC25A24
- De Novo Mutations in SLC25A24 Cause a Disorder Characterized by Early Aging, Bone Dysplasia, Characteristic Face, and Early Demise. / 02.11.2017 / PubMed / Full text
- De Novo Mutations in SLC25A24 Cause a Craniosynostosis Syndrome with Hypertrichosis, Progeroid Appearance, and Mitochondrial Dysfunction. / 02.11.2017 / PubMed / Full text
DICER1
LDHA
SNCB
- Age-related distribution and potential role of SNCB in topographically different retinal areas of the common marmoset Callithrix jacchus, including the macula. / 08.2019 / PubMed / Full text
- Age-related Beta-synuclein Alters the p53/Mdm2 Pathway and Induces the Apoptosis of Brain Microvascular Endothelial Cells In Vitro. / 05.2018 / PubMed / Full text
AQP3
HRAS
SUV39H1
E2F2
- MicroRNA-31a-5p from aging BMSCs links bone formation and resorption in the aged bone marrow microenvironment. / 08.2018 / PubMed / Full text
- In situ regeneration of retinal pigment epithelium by gene transfer of E2F2: a potential strategy for treatment of macular degenerations. / 12.2017 / PubMed / Full text
VCAN
- Deletion of miR-126a Promotes Hepatic Aging and Inflammation in a Mouse Model of Cholestasis. / 07.06.2019 / PubMed / Full text
- Exosomes from hyperglycemia-stimulated vascular endothelial cells contain versican that regulate calcification/senescence in vascular smooth muscle cells. / 2019 / PubMed / Full text
EDARADD
TAT
TCF7L2
- A myelin-related transcriptomic profile is shared by Pitt-Hopkins syndrome models and human autism spectrum disorder. / 03.2020 / PubMed / Full text
- Lifelong physical activity is associated with promoter hypomethylation of genes involved in metabolism, myogenesis, contractile properties and oxidative stress resistance in aged human skeletal muscle. / 01.03.2019 / PubMed / Full text
GRIK2
TTN
PIEZO1
HAPLN1
DAPK1
- SerThr-PhosphoProteome of Brain from Aged PINK1-KO+A53T-SNCA Mice Reveals pT1928-MAP1B and pS3781-ANK2 Deficits, as Hub between Autophagy and Synapse Changes. / 04.07.2019 / PubMed / Full text
- Degradation of Caytaxin Causes Learning and Memory Deficits via Activation of DAPK1 in Aging. / 05.2019 / PubMed / Full text
KIT
RIG
CXCL5
- Hassall's corpuscles with cellular-senescence features maintain IFNα production through neutrophils and pDC activation in the thymus. / 05.03.2019 / PubMed / Full text
- Urine Cytokine and Chemokine Levels Predict Urinary Tract Infection Severity Independent of Uropathogen, Urine Bacterial Burden, Host Genetics, and Host Age. / 09.2018 / PubMed / Full text
MEIS1
CCNG2
BGN
TRPM8
- Morphological and functional changes in TRPM8-expressing corneal cold thermoreceptor neurons during aging and their impact on tearing in mice. / 01.08.2018 / PubMed / Full text
- A comparative study on the therapeutic effect of TRPV1, TRPA1, and TRPM8 agonists on swallowing dysfunction associated with aging and neurological diseases. / 02.2018 / PubMed / Full text
HLA-A
- Reduced expression of the lncRNA NRON is a potential hallmark of the CMV-amplified CD8+ T cell accumulations commonly seen in older humans. / 01.2019 / PubMed / Full text
- Cytomegalovirus-Specific T Cells Restricted by HLA-Cw*0702 Increase Markedly with Age and Dominate the CD8 T-Cell Repertoire in Older People. / 2017 / PubMed / Full text
PER1
- Quercetin, caffeic acid and resveratrol regulate circadian clock genes and aging-related genes in young and old human lung fibroblast cells. / 02.2020 / PubMed / Full text
- Is the aging human ovary still ticking?: Expression of clock-genes in luteinized granulosa cells of young and older women. / 21.11.2018 / PubMed / Full text
RUNX1
CCL21
PIK3CG
- Myocyte enhancer factor 2A delays vascular endothelial cell senescence by activating the PI3K/p-Akt/SIRT1 pathway. / 10.06.2019 / PubMed / Full text
- MEF2A alters the proliferation, inflammation-related gene expression profiles and its silencing induces cellular senescence in human coronary endothelial cells. / 18.03.2019 / PubMed / Full text
TBK1
AMT
CDK1
- MicroRNAomic Transcriptomic Analysis Reveal Deregulation of Clustered Cellular Functions in Human Mesenchymal Stem Cells During in Vitro Passaging. / 02.2020 / PubMed / Full text
- Targeting DTL induces cell cycle arrest and senescence and suppresses cell growth and colony formation through TPX2 inhibition in human hepatocellular carcinoma cells. / 2018 / PubMed / Full text
FN1
HCN1
- Protein expression changes of HCN1 and HCN2 in hippocampal subregions of gerbils during the normal aging process. / 11.2019 / PubMed / Full text
- HCN as a Mediator of Urinary Homeostasis: Age-Associated Changes in Expression and Function in Adrenergic Detrusor Relaxation. / 15.02.2019 / PubMed / Full text
TRPC6
ALKBH8
- Loss of epitranscriptomic control of selenocysteine utilization engages senescence and mitochondrial reprogramming . / 01.2020 / PubMed / Full text
- ALKB-8, a 2-Oxoglutarate-Dependent Dioxygenase and S-Adenosine Methionine-Dependent Methyltransferase Modulates Metabolic Events Linked to Lysosome-Related Organelles and Aging in C. elegans. / 2018 / PubMed
PF4
MAPK3
- A tyrosine kinase-activating variant Asn666Ser in PDGFRB causes a progeria-like condition in the severe end of Penttinen syndrome. / 04.2019 / PubMed / Full text
- Micro-RNAS Regulate Metabolic Syndrome-induced Senescence in Porcine Adipose Tissue-derived Mesenchymal Stem Cells through the P16/MAPK Pathway. / 10.2018 / PubMed / Full text
GATA3
- An imbalance in the T-helper phenotypes displayed by senescent CD4 CD28 T cells is associated with erosive arthritis (rhupus syndrome) in systemic lupus erythematosus. / 11.2018 / PubMed / Full text
- Expression of Luminal Progenitor Marker CD117 in the Human Breast Gland. / 12.2018 / PubMed / Full text
HLA-DPB1
BAK1
BECN1
- Calpain-dependent Beclin1 cleavage stimulates senescence-associated cell death in HT22 hippocampal cells under the oxidative stress conditions. / 14.05.2019 / PubMed / Full text
- Autophagy regulates the degeneration of the auditory cortex through the AMPK-mTOR-ULK1 signaling pathway. / 04.2018 / PubMed / Full text
TIMP1
- Design, cyclization, and optimization of MMP13-TIMP1 interaction-derived self-inhibitory peptides against chondrocyte senescence in osteoarthritis. / 01.2019 / PubMed / Full text
- Retinoic acid promotes in vitro follicle activation in the cat ovary by regulating expression of matrix metalloproteinase 9. / 2018 / PubMed / Full text
APOA5
- Critical Role of SREBP-1c Large-VLDL Pathway in Environment-Induced Hypertriglyceridemia of Apo AV Deficiency. / 03.2019 / PubMed / Full text
- Longitudinal interaction between APOA5 -1131T>C and overweight in the acceleration of age-related increase in arterial stiffness through the regulation of circulating triglycerides. / 02.2019 / PubMed / Full text
FOXF1
- Functional CRISPR screen identifies AP1-associated enhancer regulating FOXF1 to modulate oncogene-induced senescence. / 17.08.2018 / PubMed / Full text
- Co-culturing nucleus pulposus mesenchymal stem cells with notochordal cell-rich nucleus pulposus explants attenuates tumor necrosis factor-α-induced senescence. / 26.06.2018 / PubMed / Full text
GK
TMPRSS2
- Susceptibility to COVID-19 in populations with health disparities: Posited involvement of mitochondrial disorder, socioeconomic stress, and pollutants. / 09.09.2020 / PubMed / Full text
- Expression of the SARS-CoV-2 Entry Proteins, ACE2 and TMPRSS2, in Cells of the Olfactory Epithelium: Identification of Cell Types and Trends with Age. / 03.06.2020 / PubMed / Full text
SOST
S1PR1
PRC1
MTMR14
- EDTP/MTMR14: A novel target for improved survivorship to prolonged anoxia and cellular protein aggregates. / 13.07.2019 / PubMed / Full text
- Downregulation of EDTP in glial cells suppresses polyglutamine protein aggregates and extends lifespan in Drosophila melanogaster. / 16.02.2019 / PubMed / Full text
ZSCAN10
CXCL11
- Endothelial cells under therapy-induced senescence secrete CXCL11, which increases aggressiveness of breast cancer cells. / 10.10.2020 / PubMed / Full text
- Prebiotic supplementation in frail older people affects specific gut microbiota taxa but not global diversity. / 13.03.2019 / PubMed / Full text
ADAM17
HMOX1
- Well-aging: A new strategy for skin homeostasis under multi-stressed conditions. / 02.2020 / PubMed / Full text
- Age-related distribution and potential role of SNCB in topographically different retinal areas of the common marmoset Callithrix jacchus, including the macula. / 08.2019 / PubMed / Full text
DLX5
MARCO
CDKN2B
- Molecular Genetics and Functional Analysis Implicate [i]CDKN2BAS1-CDKN2B[/i] Involvement in POAG Pathogenesis. / 21.08.2020 / PubMed / Full text
- Interference of the long noncoding RNA CDKN2B-AS1 upregulates miR-181a-5p/TGFβI axis to restrain the metastasis and promote apoptosis and senescence of cervical cancer cells. / 04.2019 / PubMed / Full text
LIF
CCN3
FOXP3
- Regulatory T-cells regulate neonatal heart regeneration by potentiating cardiomyocyte proliferation in a paracrine manner. / 2019 / PubMed / Full text
- Enhanced expression of PD-1 and other activation markers by CD4+ T cells of young but not old patients with metastatic melanoma. / 06.2018 / PubMed / Full text
PSEN2
C9orf72
- Carriership of two copies of C9orf72 hexanucleotide repeat intermediate-length alleles is a risk factor for ALS in the Finnish population. / 09.11.2020 / PubMed / Full text
- C9orf72 Dipeptide Repeats Cause Selective Neurodegeneration and Cell-Autonomous Excitotoxicity in [i]Drosophila[/i] Glutamatergic Neurons. / 29.08.2018 / PubMed / Full text
DSP
- Noradrenergic dysfunction accelerates LPS-elicited inflammation-related ascending sequential neurodegeneration and deficits in non-motor/motor functions. / 10.2019 / PubMed / Full text
- Trade-offs in aging lung diseases: a review on shared but opposite genetic risk variants in idiopathic pulmonary fibrosis, lung cancer and chronic obstructive pulmonary disease. / 05.2018 / PubMed / Full text
F7
- The Pattern of Mu Rhythm Modulation During Emotional Destination Memory: Comparison Between Mild Cognitive Impairment Patients and Healthy Controls. / 2019 / PubMed / Full text
- High levels of incidental physical activity are positively associated with cognition and EEG activity in aging. / 2018 / PubMed / Full text
ATG12
FANCD2
CAST
DRD3
- Image-guided phenotyping of ovariectomized mice: altered functional connectivity, cognition, myelination, and dopaminergic functionality. / 02.2019 / PubMed / Full text
- Dopamine-Related Genotypes and Physical Activity Change During an Intervention: The Lifestyle Interventions and Independence for Elders Study. / 07.2018 / PubMed / Full text
ID3
CHM
GPR39
B2M
- The relationships between markers of tubular injury and intrarenal haemodynamic function in adults with and without type 1 diabetes: Results from the Canadian Study of Longevity in Type 1 Diabetes. / 03.2019 / PubMed / Full text
- Association between serum β2-microglobulin levels and frailty in an elderly Chinese population: results from RuLAS. / 2017 / PubMed / Full text
HBP1
DEGS1
ACOX1
- Dietary methionine increased the lipid accumulation in juvenile tiger puffer Takifugu rubripes. / 04.2019 / PubMed / Full text
- Peroxisomal Acyl-CoA Oxidase Type 1: Anti-Inflammatory and Anti-Aging Properties with a Special Emphasis on Studies with LPS and Argan Oil as a Model Transposable to Aging. / 2018 / PubMed / Full text
TXNRD2
SAA1
- Naturally occurring antibodies against serum amyloid A reduce IL-6 release from peripheral blood mononuclear cells. / 2018 / PubMed / Full text
- Association between local inflammation and breast tissue age-related lobular involution among premenopausal and postmenopausal breast cancer patients. / 2017 / PubMed / Full text
STIM1
LAMP2
CPE
- Cross-Sectional and Cumulative Longitudinal Central Nervous System Penetration Effectiveness Scores Are Not Associated With Neurocognitive Impairment in a Well Treated Aging Human Immunodeficiency Virus-Positive Population in Switzerland. / 07.2019 / PubMed / Full text
- COCOA (Theobroma cacao) Polyphenol-Rich Extract Increases the Chronological Lifespan of Saccharomyces cerevisiae. / 2016 / PubMed
STAT5A
NTS
- Neuropeptide changes in the suprachiasmatic nucleus are associated with the development of hypertension. / 08.2019 / PubMed / Full text
- Aging affects isoproterenol-induced water drinking, astrocyte density, and central neuronal activation in female Brown Norway rats. / 01.08.2018 / PubMed / Full text
PGP
- Age-associated changes of the intrinsic nervous system in relation with interstitial cells in the pre-weaning goat rumen. / 14.07.2019 / PubMed / Full text
- Changes in the interstitial cells of Cajal and neuronal nitric oxide synthase positive neuronal cells with aging in the esophagus of F344 rats. / 2017 / PubMed / Full text
GDF3
TNNT3
- Genome-wide associations and detection of potential candidate genes for direct genetic and maternal genetic effects influencing dairy cattle body weight at different ages. / 06.02.2019 / PubMed / Full text
- Troponin T3 associates with DNA consensus sequence that overlaps with p53 binding motifs. / 15.07.2018 / PubMed / Full text
GPT
- Brain Structural-Behavioral Correlates Underlying Grooved Pegboard Test Performance Across Lifespan. / 07.07.2020 / PubMed / Full text
- Effects of tDCS of Dorsolateral Prefrontal Cortex on Dual-Task Performance Involving Manual Dexterity and Cognitive Task in Healthy Older Adults. / 2019 / PubMed / Full text
ANGPTL2
- Circulating angiopoietin-like protein 2 levels and mortality risk in patients receiving maintenance hemodialysis: a prospective cohort study. / 01.05.2020 / PubMed / Full text
- Age-dependent increase in angiopoietin-like protein 2 accelerates skeletal muscle loss in mice. / 02.02.2018 / PubMed / Full text
IL1A
PUM2
BTK
MALT1
DAO
FSTL3
BMP15
GIT2
PTS
FUNDC1
GNG3
CRABP2
GRSF1
BIN1
IL7
LOXL2
WIPI2
- Neuronal autophagy declines substantially with age and is rescued by overexpression of WIPI2. / 02.2020 / PubMed / Full text
- The ATG5-binding and coiled coil domains of ATG16L1 maintain autophagy and tissue homeostasis in mice independently of the WD domain required for LC3-associated phagocytosis. / 04.2019 / PubMed / Full text
TBC1D5
PLK4
LCT
XRCC1
GAS6
SPR
RTEL1
CBL
CCR6
LONP1
TRPM7
PDCD4
TLR7
- Bovine Lactoferrin Enhances TLR7-Mediated Responses in Plasmacytoid Dendritic Cells in Elderly Women: Results From a Nutritional Intervention Study With Bovine Lactoferrin, GOS and Vitamin D. / 2018 / PubMed / Full text
- B cell responses to apoptotic cells in MFG-E8-/- mice. / 2018 / PubMed / Full text
PGD
PTX3
- Aerobic Training Down-Regulates Pentraxin 3 and Pentraxin 3/Toll-Like Receptor 4 Ratio, Irrespective of Oxidative Stress Response, in Elderly Subjects. / 27.01.2020 / PubMed / Full text
- Sex Differences in the Association Between Pentraxin 3 and Cognitive Decline: The Cardiovascular Health Study. / 13.07.2020 / PubMed / Full text
TAS2R38
- TAS2R38 bitter taste receptor and attainment of exceptional longevity. / 02.12.2019 / PubMed / Full text
- Bitter, Sweet, Salty, Sour and Umami Taste Perception Decreases with Age: Sex-Specific Analysis, Modulation by Genetic Variants and Taste-Preference Associations in 18 to 80 Year-Old Subjects. / 18.10.2018 / PubMed / Full text
ETS1
- The transcription factor ETS1 promotes apoptosis resistance of senescent cholangiocytes by epigenetically up-regulating the apoptosis suppressor BCL2L1. / 06.12.2019 / PubMed / Full text
- G protein-coupled receptor kinase 4-induced cellular senescence and its senescence-associated gene expression profiling. / 15.11.2017 / PubMed / Full text
SMAD4
DDB1
DKC1
DST
S100A4
- Protective role of mesenchymal stem cells and mesenchymal stem cell-derived exosomes in cigarette smoke-induced mitochondrial dysfunction in mice. / 15.12.2019 / PubMed / Full text
- Tissue Taurine Depletion Induces Profibrotic Pattern of Gene Expression and Causes Aging-Related Cardiac Fibrosis in Heart in Mice. / 2018 / PubMed / Full text
DDX41
MVD
GALT
GATA2
ACTA1
- Explaining meat quality of bulls and steers by differential proteome and phosphoproteome analysis of skeletal muscle. / 15.05.2019 / PubMed / Full text
- Serum starvation of ARPE-19 changes the cellular distribution of cholesterol and Fibulin3 in patterns reminiscent of age-related macular degeneration. / 15.12.2017 / PubMed / Full text
CYP3A4
- Application of a physiologically based pharmacokinetic model for the prediction of mirabegron plasma concentrations in a population with severe renal impairment. / 05.2019 / PubMed / Full text
- Effect of Age and Allele Variants of CYP3A5, CYP3A4, and POR Genes on the Pharmacokinetics of Cyclosporin A in Pediatric Renal Transplant Recipients From Serbia. / 12.2017 / PubMed / Full text
ACTB
AGT
ZEB2
PDE4D
- Phosphodiesterase PDE4D Is Decreased in Frontal Cortex of Aged Rats and Positively Correlated With Working Memory Performance and Inversely Correlated With PKA Phosphorylation of Tau. / 2020 / PubMed / Full text
- Compound D159687, a phosphodiesterase 4D inhibitor, induces weight and fat mass loss in aged mice without changing lean mass, physical and cognitive function. / 02.12.2018 / PubMed / Full text
RAD52
- Quantitative assessment of changes in cell growth, size and morphology during telomere-initiated cellular senescence in Saccharomyces cerevisiae. / 01.08.2019 / PubMed / Full text
- Increased age-adjusted hazard of death associated with a common single nucleotide polymorphism of the human RAD52 gene in a cardiovascular cohort. / 10.2017 / PubMed / Full text
PPM1D
CYP7A1
APPL2
- The reversal effect of physical exercise on aging-related increases in APPL2 content in skeletal muscle. / 01.10.2018 / PubMed / Full text
- Adaptor Protein APPL2 Affects Adult Antidepressant Behaviors and Hippocampal Neurogenesis via Regulating the Sensitivity of Glucocorticoid Receptor. / 07.2018 / PubMed / Full text
ABCA1
- Intracellular cholesterol stimulates ENaC by interacting with phosphatidylinositol‑4,5‑bisphosphate and mediates cyclosporine A-induced hypertension. / 01.07.2019 / PubMed / Full text
- Disrupted cholesterol metabolism promotes age-related photoreceptor neurodegeneration. / 08.2018 / PubMed / Full text
MDH1
CD22
HSPA1A
- Vitamin D3 treatment regulates apoptosis, antioxidant defense system, and DNA integrity in the epididymal sperm of an aged rat model. / 12.2019 / PubMed / Full text
- The effect of aging on the autophagic and heat shock response in human peripheral blood mononuclear cells. / 01.09.2018 / PubMed / Full text
HCRT
RRM2B
INPP4B
PDGFRB
CYP2R1
CIP2A
ANGPTL4
FMO3
WLS
BBS5
UCHL1
PLA2G6
FMR1
MAP1A
IL13
DUSP8
TNFSF15
FAR2
NOA1
SPP1
TOR2A
WFIKKN2
ACMSD
HSD3B2
PREP
OSM
UGT2B7
EDN1
NAIP
PIK3C2A
NUCB2
ACTR3B
HES1
DRD1
PSMB8
GP6
AOX1
MRO
LRP1
RXRG
GORAB
PABPN1
CBX8
BAG3
KCNAB3
SRSF3
NGFR
COQ7
GPX2
PRKCH
FASN
SAT1
GADD45B
SALL1
LRP2
PDK4
TRIM28
RRAD
ECRG4
COL6A1
FSTL1
CREB5
MTRR
FADD
SND1
DDR1
ST18
TGM2
SP1
CIZ1
RORA
FOXP2
STC2
CXCR5
DDR2
DBH
NMUR1
TXN
HJV
TP73
MICB
PTN
MCM3
UCN
IGFBP7
KLF2
LIPA
SMARCB1
IP6K1
NBR1
PPP2R3C
CFH
USP8
PRNP
SV2B
CCN4
BANF1
TNP2
SMYD2
GDF9
KLF5
BTC
BARD1
PEBP1
NMI
TAF7
NLRX1
HHLA2
WT1
PPARG
PTK7
VASH1
TRAV27
ACSL5
HNRNPA0
MCF2L
ALOX12
RARB
COL1A1
ATF2
USF2
CLN3
GNAQ
MC1R
ERCC5
S1PR3
SATB2
SELENOK
GAB2
ITGA3
NRM
PRM2
DLAT
ACAT2
UBTF
WFIKKN1
GSTM3
YES1
GSN
RB1
MR1
LRP8
HLA-DMA
OOEP
ACAN
SOX13
TOP1
ST6GAL1
HSP90AA1
ZNF467
CYP26A1
SDC4
RPA2
HSPG2
NEK2
MAOA
HSPB1
LTF
EID3
GRM3
USP7
JAK3
ULK2
SPHK1
CTC1
CXCL16
ENTPD7
P2RY10
IFNG
PTTG1
CYP1B1
MCM6
LMX1A
POLL
TGFB1
IFIT1
UBE2E3
PAX7
PTPRR
ABCC9
NFATC1
EIF4E
SCAMP4
MYSM1
INHBA
BTG1
OMD
IMMP2L
TRIB2
ABLIM3
USF1
ASMT
ERBB4
CHRNE
CPT1B
CNP
MCAT
ALKBH2
- ALKB-8, a 2-Oxoglutarate-Dependent Dioxygenase and S-Adenosine Methionine-Dependent Methyltransferase Modulates Metabolic Events Linked to Lysosome-Related Organelles and Aging in C. elegans. / 2018 / PubMed
SELENOP
ELF3
SCN9A
ZBTB16
NDUFV2
NEFM
GPC1
NEIL1
SRY
SCGN
PYCR1
PGLS
CASP3
- Does cartilage ERα overexpression correlate with osteoarthritic chondrosenescence? Indications from [i]Labisia pumila[/i] OA mitigation. / 09.2019 / PubMed
CLEC4E
GRID1
IPMK
EIF2B1
WNK1
BCL2L11
ARID5A
SELENOW
PON1
PRKDC
MAPK11
CCNA2
EPHA2
DLGAP2
PIGR
STK3
CARF
MAP2K3
IRF1
ALK
RSF1
CDC25A
P4HA3
SLC15A2
CREB1
CUX1
APOC3
CBX4
PLK1
RUNX3
CCND3
LDLR
SUN2
PPA2
TXNDC5
MAP4K3
NKX2-5
TJP1
MAS1
IL4
TRIM27
FBXO46
MATN3
TRIB3
BCL11B
TRPC1
DEPTOR
SYNJ2
RNF144A
PKD1
PDHB
NLRP1
GYS2
MS4A1
LPAR3
DYRK1A
HSD17B14
GNPAT
SMAD1
PDE10A
ATXN1
KCTD12
PHB
CYP26B1
ATXN3
PCMTD1
GCAT
KDM4A
TBC1D1
FER
MAP3K5
KLB
CHEK2
RBM3
TP53INP1
FOXD1
ALDH3A1
GRIN2B
MCM4
ZNF207
MPST
TPH1
NRXN3
SDC3
HLA-DQB1
APLP2
EZR
RAD51C
GPBAR1
MS4A6A
UCN3
CTSS
MECOM
CA12
SDHB
DUSP1
EVL
PRKN
BNC1
SMN1
PDE9A
EXD2
GOT1
OGA
PRRX1
TINF2
USP15
LGALS3
ATP6V0C
ARID1B
FRG1
PTPRD
ADRM1
ESPL1
PGK2
IL18
PDE5A
SIX3
RAD51B
MLH3
KCNB1
AHCY
WDR73
INHBE
FOXN1
TRIP13
IL17RA
MRPS5
TEF
HPD
RXRA
RPS19BP1
UQCRC2
ITK
NSF
COL12A1
SELENOT
FA2H
RACK1
FAHD1
MST1
- [Expression relationship of Hippo signaling molecules and ovarian germline stem cell markers in the ovarian aging process of women and mice]. / 25.06.2019 / PubMed
NTHL1
KCNQ4
ITGB4
MRTFA
KLF6
FABP1
CHIA
SGSH
MX1
BCAS1
KCNQ2
CPT1A
ADNP2
SMARCD1
ARNTL2
SYP
AXL
MSH3
HAP1
EML6
NT5E
PTK2B
OXR1
GLI1
SP7
SFRP5
PPARGC1A
HMGCS1
COQ6
IGHD
TEP1
- [Influence of Age on the Susceptibility of Anopheles stephensi to Plasmodium berghei Infection]. / 12.2016 / PubMed
MAF
NDUFS8
RPL36
CACNA1B
CBX3
MEOX2
CLEC3B
ECSIT
KRT15
SARM1
HLA-DPA1
GSTT1
IKBKB
MAPK13
E2F3
PAX5
BHLHE40
TLR3
PPFIA1
RBP1
FGFR2
SUCNR1
MMP12
STN1
NEO1
CNTF
DYNC2H1
PHGDH
HSPB6
DTNBP1
ATG16L1
TAAR1
MAFB
LRRK1
TECPR2
CCDC88A
NPAS2
MAF1
MBD2
BRD2
SIK3
SLC52A3
MAP1B
MGRN1
PTCH1
GZMK
HADHA
KDM2A
LIN28B
SUZ12
HIF1A
DGAT1
WNT5A
HLA-E
ELL
SUN1
JUNB
NTN4
C2CD2
WNT7A
DLC1
CETP
GIT1
UPF1
SH2B3
DEPDC5
CASS4
ZNF396
MUC5AC
TNPO3
GCK
ZFHX3
NCK2
TGFBR2
ALDOA
SLC24A5
HSPA5
SKAP2
UACA
UBE4B
CUL3
SFPQ
PEX5
RELA
THBS4
TTL
AKT2
SCN2B
TRAF2
STK32C
RAF1
VPS29
TPRKB
DPYSL2
EIF2B2
ELOVL6
G6PC3
RPL30
AKAP12
CD72
RPL31
PEX19
TRAV1-2
CAP2
MDK
AKTIP
SPRTN
SENP1
IL1R2
CXCR6
CD48
GATA1
MPHOSPH6
CXCL17
- [Age-related aspects of the involvement of heat shock proteins in the pathogenesis of osteoarthritis]. / 2017 / PubMed
ATF3
NRL
SCO1
KLF1
MYCN
ARL13B
CPNE1
PLN
POLG2
REV1
AIDA
CRBN
LRRC8B
SHANK3
SPATS2L
TAS1R2
CYP2C9
TCTA
DRAM2
PCCB
SCN2A
ARNTL
CR2
CYP24A1
HAX1
NPBWR1
FKBP5
GREM2
GSTA1
TNNI1
SMOX
GRK6
PRM1
MAX
LHCGR
LCN2
ICAM1
DPP6
PFKFB3
GPR37
HYOU1
GUK1
AQP4
ELANE
SLC16A7
CD2
ERCC8
MFSD2A
SDC2
ACD
NRARP
CTNS
TYK2
GPR158
NPC2
RAI1
TSHB
ABCG5
SOS1
SLC30A1
NDUFS1
SELENOV
PRMT1
HAS2
KDM2B
ITGB1
EFEMP1
S100A12
ATG10
PSMG1
NDRG1
AP2B1
UGT2B28
PTGS2
MCM5
LAMA2
ACVR1
VASP
PPM1A
RNF13
VSIG4
AMHR2
ATP6V1E1
TGDS
CDKN1C
CXCL14
EWSR1
RNF10
SMO
ERCC2
NDRG2
AMFR
DES
UBB
RAD23A
TSG101
HNRNPA1
ATP2B1
ANG
PTPN1
GRB10
BAZ2B
REC8
LRP6
TRPV6
VHLL
POU5F1
HDAC10
FDPS
GDA
BOC
APLNR
LEF1
RHOB
SNAI2
UCP3
APPL1
DGCR8
VCL
CDH1
GP1BA
SMC2
ACADM
SYT7
ATG4D
CREBBP
ADAMTS3
IGFBP4
KY
ANGPT2
PF4V1
WNK4
RRM1
CINP
NPM1
GRK4
PRMT8
FADS1
ATG4B
PSMD13
PBX1
PGAP1
RBP4
SAMD12
RXFP3
CEL
UBE3A
SEMA3A
HRH4
- Histamime Receptor H4 as a New Therapeutic Target for Age-related Macular Degeneration. / 11.2016 / PubMed
VPREB3
FRG2
CYP19A1
AANAT
ALKBH1
- ALKB-8, a 2-Oxoglutarate-Dependent Dioxygenase and S-Adenosine Methionine-Dependent Methyltransferase Modulates Metabolic Events Linked to Lysosome-Related Organelles and Aging in C. elegans. / 2018 / PubMed