Aging genes 3-9

• Genes with 100 and more publications
• Genes with 60-99 publications
• Genes with 30-59 publications
• Genes with 10-29 publications
• Genes with 3-9 publications
• Genes with 1-2 publications

ATG7

• Age-related impairment of autophagy in cervical motor neurons. / 05.12.2020 / PubMed / Full text
• Comprehensive Bioinformatics Identifies Key microRNA Players in ATG7-Deficient Lung Fibroblasts. / 09.06.2020 / PubMed / Full text
• Regulation of autophagy by DNA G-quadruplexes. / 18.05.2020 / PubMed / Full text
• ATG7 is essential for secretion of iron from ameloblasts and normal growth of murine incisors during aging. / 10.2020 / PubMed / Full text
• Enhancing Autophagy Diminishes Aberrant Ca Homeostasis and Arrhythmogenesis in Aging Rabbit Hearts. / 2019 / PubMed / Full text
• Adipose-Derived Stem/Stromal Cells Recapitulate Aging Biomarkers and Show Reduced Stem Cell Plasticity Affecting Their Adipogenic Differentiation Capacity. / 08.2019 / PubMed / Full text
• Inhibition of glioma growth by flavokawain B is mediated through endoplasmic reticulum stress induced autophagy. / 2018 / PubMed / Full text
• Carvacrol nanoemulsion evokes cell cycle arrest, apoptosis induction and autophagy inhibition in doxorubicin resistant-A549 cell line. / 2018 / PubMed / Full text
• SIRT6 histone deacetylase functions as a potential oncogene in human melanoma. / 09.2017 / PubMed / Full text

BAX

• Clearance of therapy-induced senescent tumor cells by the senolytic ABT-263 via interference with BCL-X -BAX interaction. / 10.2020 / PubMed / Full text
• CREB Signaling Mediates Dose-Dependent Radiation Response in the Murine Hippocampus Two Years after Total Body Exposure. / 03.01.2020 / PubMed / Full text
• Reduced sucrose nonfermenting AMPK-related kinase (SNARK) activity aggravates cancer-induced skeletal muscle wasting. / 09.2019 / PubMed / Full text
• Modulated electro-hyperthermia induced p53 driven apoptosis and cell cycle arrest additively support doxorubicin chemotherapy of colorectal cancer in vitro. / 08.2019 / PubMed / Full text
• The Clearance Effect of Tetrahedral DNA Nanostructures on Senescent Human Dermal Fibroblasts. / 16.01.2019 / PubMed / Full text
• Premature placental aging in term small-for-gestational-age and growth-restricted fetuses. / 05.2019 / PubMed / Full text
• Regulation of apoptosis and autophagy in mouse and human skeletal muscle with aging and lifelong exercise training. / 01.10.2018 / PubMed / Full text
• Xanthohumol exerts protective effects in liver alterations associated with aging. / 03.2019 / PubMed / Full text
• Protective effect of xanthohumol against age-related brain damage. / 11.2017 / PubMed / Full text

BRAF

• Conditional reprograming culture conditions facilitate growth of lower grade glioma models. / 01.12.2020 / PubMed / Full text
• Active notch protects MAPK activated melanoma cell lines from MEK inhibitor cobimetinib. / 14.11.2020 / PubMed / Full text
• Mitochondrial metabolic reprograming via BRAF inhibition ameliorates senescence. / 15.10.2019 / PubMed / Full text
• Deciphering the genotype and phenotype of hairy cell leukemia: clues for diagnosis and treatment. / 08.2019 / PubMed / Full text
• A clinical trial of somatic and germline analyses for healthy longevity in a postoperative cancer patient. / 09.2019 / PubMed / Full text
• Aging-like Spontaneous Epigenetic Silencing Facilitates Wnt Activation, Stemness, and Braf -Induced Tumorigenesis. / 11.02.2019 / PubMed / Full text
• Acquired resistance to BRAFi reverses senescence-like phenotype in mutant BRAF melanoma. / 07.08.2018 / PubMed / Full text
• Cancer modeling by Transgene Electroporation in Adult Zebrafish (TEAZ). / 27.09.2018 / PubMed / Full text
• Menopause and adipose tissue: miR-19a-3p is sensitive to hormonal replacement. / 05.01.2018 / PubMed / Full text

CCS

• Frailty Significantly Associated with a Risk for Mid-term Outcomes in Elderly Chronic Coronary Syndrome Patients: a Prospective Study. / 01.12.2020 / PubMed / Full text
• Microbleeds and Medial Temporal Atrophy Determine Cognitive Trajectories in Normal Aging: A Longitudinal PET-MRI Study. / 2020 / PubMed / Full text
• Hippocampal Volume Loss, Brain Amyloid Accumulation, and APOE Status in Cognitively Intact Elderly Subjects. / 2019 / PubMed / Full text
• Amyloid Load, Hippocampal Volume Loss, and Diffusion Tensor Imaging Changes in Early Phases of Brain Aging. / 2019 / PubMed / Full text
• Lower bone mass is associated with subclinical atherosclerosis, endothelial dysfunction and carotid thickness in the very elderly. / 01.2020 / PubMed / Full text
• Cardiovascular Risk Assessment and Follow-Up of Women After Hypertensive Disorders of Pregnancy:A Prospective Cohort Study. / 08.2019 / PubMed / Full text
• T cell epigenetic remodeling and accelerated epigenetic aging are linked to long-term immune alterations in childhood cancer survivors. / 06.11.2018 / PubMed / Full text
• Circulating microRNAs disclose biology of normal cognitive function in healthy elderly people - a discovery twin study. / 09.2018 / PubMed / Full text
• High risk of hypogonadism in young male cancer survivors. / 03.2018 / PubMed / Full text

CDK2

• p57 is a master regulator of human adipose derived stem cell quiescence and senescence. / 04.2020 / PubMed / Full text
• Induction of Senescence in Cancer Cells by a Novel Combination of Cucurbitacin B and Withanone: Molecular Mechanism and Therapeutic Potential. / 22.05.2020 / PubMed / Full text
• Cyclin-Dependent Kinase 2 in Cellular Senescence and Cancer. A Structural and Functional Review. / 2019 / PubMed / Full text
• Tenovin-1 Induces Senescence and Decreases Wound-Healing Activity in Cultured Rat Primary Astrocytes. / 01.05.2019 / PubMed / Full text
• Relationship between intermuscular adipose tissue infiltration and myostatin before and after aerobic exercise training. / 01.09.2018 / PubMed / Full text
• Carvacrol nanoemulsion evokes cell cycle arrest, apoptosis induction and autophagy inhibition in doxorubicin resistant-A549 cell line. / 2018 / PubMed / Full text
• Gut flora-dependent metabolite Trimethylamine-N-oxide accelerates endothelial cell senescence and vascular aging through oxidative stress. / 20.02.2018 / PubMed / Full text
• Inhibition of CIP2A attenuates tumor progression by inducing cell cycle arrest and promoting cellular senescence in hepatocellular carcinoma. / 08.01.2018 / PubMed / Full text
• G protein-coupled receptor kinase 4-induced cellular senescence and its senescence-associated gene expression profiling. / 15.11.2017 / PubMed / Full text

CDK6

• Saturated Fatty Acids Promote Hepatocytic Senecence through Regulation of miR-34a/Cyclin-Dependent Kinase 6. / 24.09.2020 / PubMed / Full text
• Hepatoprotective effects of hydroxysafflor yellow A in D-galactose-treated aging mice. / 15.08.2020 / PubMed / Full text
• Anti-cell growth and anti-cancer stem cell activity of the CDK4/6 inhibitor palbociclib in breast cancer cells. / 05.2020 / PubMed / Full text
• Compromising the constitutive p16 expression sensitizes human neuroblastoma cells to Hsp90 inhibition and promotes premature senescence. / 04.2020 / PubMed / Full text
• Palbociclib Effectively Halts Proliferation but Fails to Induce Senescence in Patient-Derived Glioma Stem Cells. / 11.2019 / PubMed / Full text
• Avenanthramide A Induces Cellular Senescence via miR-129-3p/Pirh2/p53 Signaling Pathway To Suppress Colon Cancer Growth. / 01.05.2019 / PubMed / Full text
• Carvacrol nanoemulsion evokes cell cycle arrest, apoptosis induction and autophagy inhibition in doxorubicin resistant-A549 cell line. / 2018 / PubMed / Full text
• Preclinical characterization of abemaciclib in hormone receptor positive breast cancer. / 19.09.2017 / PubMed / Full text
• G protein-coupled receptor kinase 4-induced cellular senescence and its senescence-associated gene expression profiling. / 15.11.2017 / PubMed / Full text

CX3CR1

• Monocytes present age-related changes in phospholipid concentration and decreased energy metabolism. / 04.2020 / PubMed / Full text
• Muscle Injury Induces Postoperative Cognitive Dysfunction. / 17.02.2020 / PubMed / Full text
• Dexamethasone Induces a Specific Form of Ramified Dysfunctional Microglia. / 02.2019 / PubMed / Full text
• Surgical Trauma Exacerbates Cognitive Deficits and Neuroinflammation in Aged Rats: The Role of CX3CL1-CX3CR1 Signaling. / 01.08.2018 / PubMed / Full text
• Repopulating retinal microglia restore endogenous organization and function under CX3CL1-CX3CR1 regulation. / 03.2018 / PubMed / Full text
• Cryopreserved whole blood for the quantification of monocyte, T-cell and NK-cell subsets, and monocyte receptor expression by multi-color flow cytometry: A methodological study based on participants from the canadian longitudinal study on aging. / 05.2018 / PubMed / Full text
• Microglia and Aging: The Role of the TREM2-DAP12 and CX3CL1-CX3CR1 Axes. / 22.01.2018 / PubMed / Full text
• Strain specificities in age-related changes in mechanisms promoting and controlling rat spinal cord damage in experimental autoimmune encephalomyelitis. / 01.2018 / PubMed / Full text
• Sex as a determinant of age-related changes in rat spinal cord inflammation-oxidation state. / 10.2017 / PubMed / Full text

DCX

• GSK-3β activation accelerates early-stage consumption of Hippocampal Neurogenesis in senescent mice. / 2020 / PubMed / Full text
• Doublecortin and IGF-1R protein levels are reduced in spite of unchanged DNA methylation in the hippocampus of aged rats. / 04.2020 / PubMed / Full text
• Human Hippocampal Neurogenesis Persists in Aged Adults and Alzheimer's Disease Patients. / 06.06.2019 / PubMed / Full text
• Age-related changes in Ki-67 and DCX expression in the BALB/ c mouse (Mus Musculus) brain. / 02.2019 / PubMed / Full text
• Inflammation-induced Gro1 triggers senescence in neuronal progenitors: effects of estradiol. / 11.09.2018 / PubMed / Full text
• Neuroprotective Effects of the Multitarget Agent AVCRI104P3 in Brain of Middle-Aged Mice. / 04.09.2018 / PubMed / Full text
• Differential effects of adolescent and adult-initiated voluntary exercise on context and cued fear conditioning. / 02.2019 / PubMed / Full text
• Hippocampal neurogenesis in the C57BL/6J mice at early adulthood following prenatal alcohol exposure. / 04.2018 / PubMed / Full text
• Puerarin and Amlodipine Improvement of D-Galactose-Induced Impairments of Behaviour and Neurogenesis in Mouse Dentate Gyrus: Correlation with Glucocorticoid Receptor Expression. / 11.2017 / PubMed / Full text

E2F1

• Regulation of E2F1 activity via PKA-mediated phosphorylations. / 2020 / PubMed / Full text
• Astragaloside IV ameliorates radiation-induced senescence via antioxidative mechanism. / 08.2020 / PubMed / Full text
• E2F1 mediates the downregulation of POLD1 in replicative senescence. / 07.2019 / PubMed / Full text
• Low dose Emodin induces tumor senescence for boosting breast cancer chemotherapy via silencing NRARP. / 10.11.2018 / PubMed / Full text
• Downregulation of FOXP1 correlates with tendon stem/progenitor cells aging. / 26.09.2018 / PubMed / Full text
• Loss of circadian protein TIMELESS accelerates the progression of cellular senescence. / 18.09.2018 / PubMed / Full text
• Transcriptional Repression of High-Mobility Group Box 2 by p21 in Radiation-Induced Senescence. / 30.04.2018 / PubMed / Full text
• Genome-wide association study and annotating candidate gene networks affecting age at first calving in Nellore cattle. / 12.2017 / PubMed / Full text
• Triptolide Promotes Senescence of Prostate Cancer Cells Through Histone Methylation and Heterochromatin Formation / 27.09.2017 / PubMed / Full text

ELOVL2

• ELOVL2: Not just a biomarker of aging. / 2020 / PubMed / Full text
• The lipid elongation enzyme ELOVL2 is a molecular regulator of aging in the retina. / 02.2020 / PubMed / Full text
• Human aging DNA methylation signatures are conserved but accelerated in cultured fibroblasts. / 10.2019 / PubMed / Full text
• Cell and tissue type independent age-associated DNA methylation changes are not rare but common. / 27.11.2018 / PubMed / Full text
• DNA methylation of the ELOVL2, FHL2, KLF14, C1orf132/MIR29B2C, and TRIM59 genes for age prediction from blood, saliva, and buccal swab samples. / 01.2019 / PubMed / Full text
• Proof of concept study of age-dependent DNA methylation markers across different tissues by massive parallel sequencing. / 09.2018 / PubMed / Full text
• Age-related DNA methylation changes are tissue-specific with ELOVL2 promoter methylation as exception. / 30.05.2018 / PubMed / Full text
• DNA methylation levels in candidate genes associated with chronological age in mammals are not conserved in a long-lived seabird. / 2017 / PubMed / Full text
• Chronological age prediction based on DNA methylation: Massive parallel sequencing and random forest regression. / 11.2017 / PubMed / Full text

ERCC1

• Chronic Sildenafil Treatment Improves Vasomotor Function in a Mouse Model of Accelerated Aging. / 30.06.2020 / PubMed / Full text
• Local endothelial DNA repair deficiency causes aging-resembling endothelial-specific dysfunction. / 17.04.2020 / PubMed / Full text
• Tissue specificity of senescent cell accumulation during physiologic and accelerated aging of mice. / 03.2020 / PubMed / Full text
• Deficiency in the DNA repair protein ERCC1 triggers a link between senescence and apoptosis in human fibroblasts and mouse skin. / 03.2020 / PubMed / Full text
• Aerobic exercise promotes the expression of ERCC1 to prolong lifespan: A new possible mechanism. / 01.2019 / PubMed / Full text
• Dysregulation of DAF-16/FOXO3A-mediated stress responses accelerates oxidative DNA damage induced aging. / 09.2018 / PubMed / Full text
• ERCC1-deficient cells and mice are hypersensitive to lipid peroxidation. / 20.08.2018 / PubMed / Full text
• Spontaneous DNA damage to the nuclear genome promotes senescence, redox imbalance and aging. / 07.2018 / PubMed / Full text
• Oxidation Products of 5-Methylcytosine are Decreased in Senescent Cells and Tissues of Progeroid Mice. / 09.07.2018 / PubMed / Full text

FES

• An outpatient Tai Chi program: Effects on veterans' functional outcomes. / 26.11.2020 / PubMed / Full text
• Gait Function in Adults Aged 50 Years and Older With Spina Bifida. / 07.11.2020 / PubMed / Full text
• A Single Question as a Screening Tool to Assess Fear of Falling in Young-Old Community-Dwelling Persons. / 09.2020 / PubMed / Full text
• Fall-related efficacy is a useful and independent index to detect fall risk in Japanese community-dwelling older people: a 1-year longitudinal study. / 29.10.2019 / PubMed / Full text
• Investigating Changes in Real-time Conscious Postural Processing by Older Adults during Different Stance Positions Using Electroencephalography Coherence. / 10-12.2019 / PubMed / Full text
• Effectiveness of Daily Use of Bilateral Custom-Made Ankle-Foot Orthoses on Balance, Fear of Falling, and Physical Activity in Older Adults: A Randomized Controlled Trial. / 2019 / PubMed / Full text
• Decline in sensorimotor systems explains reduced falls self-efficacy. / 10.2018 / PubMed / Full text
• Fear of Falling in Older Adults with Diabetes Mellitus: The IMIAS Study. / 09.2018 / PubMed / Full text
• Cross-cultural adaptation and measurement properties testing of the Iconographical Falls Efficacy Scale (Icon-FES). / 07-08.2018 / PubMed / Full text

HSF1

• A Mitochondrial Stress-Specific Form of HSF1 Protects against Age-Related Proteostasis Collapse. / 28.09.2020 / PubMed / Full text
• Heat shock factor 1-mediated transcription activation of Omi/HtrA2 induces myocardial mitochondrial apoptosis in the aging heart. / 18.10.2019 / PubMed / Full text
• Multifactorial Attenuation of the Murine Heat Shock Response With Age. / 25.09.2020 / PubMed / Full text
• Nutrition and water temperature regulate the expression of heat-shock proteins in golden pompano larvae (Trachinotus ovata, Limmaeus 1758). / 04.2019 / PubMed / Full text
• CCAR-1 is a negative regulator of the heat-shock response in Caenorhabditis elegans. / 10.2018 / PubMed / Full text
• Modulation of Heat Shock Factor 1 Activity through Silencing of Ser303/Ser307 Phosphorylation Supports a Metabolic Program Leading to Age-Related Obesity and Insulin Resistance. / 15.09.2018 / PubMed / Full text
• The longevity SNP rs2802292 uncovered: HSF1 activates stress-dependent expression of FOXO3 through an intronic enhancer. / 20.06.2018 / PubMed / Full text
• Acute HSF1 depletion induces cellular senescence through the MDM2-p53-p21 pathway in human diploid fibroblasts. / 08.05.2018 / PubMed / Full text
• Azadiradione Restores Protein Quality Control and Ameliorates the Disease Pathogenesis in a Mouse Model of Huntington's Disease. / 08.2018 / PubMed / Full text

JAK2

• Senescence in Monocytes Facilitates Dengue Virus Infection by Increasing Infectivity. / 2020 / PubMed / Full text
• Quercetin Directly Targets JAK2 and PKCδ and Prevents UV-Induced Photoaging in Human Skin. / 23.10.2019 / PubMed / Full text
• [Red blood cell lifespan detected by endogenous carbon monoxide breath test in patients with polycythemia vera]. / 01.10.2019 / PubMed / Full text
• Roles of JAK2 in Aging, Inflammation, Hematopoiesis and Malignant Transformation. / 08.08.2019 / PubMed / Full text
• The mir-465 family is upregulated with age and attenuates growth hormone signaling in mouse liver. / 04.2019 / PubMed / Full text
• Clonal hematopoiesis: Genes and underlying mechanisms in cardiovascular disease development. / 06.2019 / PubMed / Full text
• Distinctive features of polycythaemia vera in New Zealand Polynesians. / 21.09.2018 / PubMed
• Immunologic effects of chronic administration of tofacitinib, a Janus kinase inhibitor, in cynomolgus monkeys and rats - Comparison of juvenile and adult responses. / 04.2018 / PubMed / Full text
• Molecular Pathogenesis of Myeloproliferative Neoplasms: Influence of Age and Gender. / 10.2017 / PubMed / Full text

LPO

• [Features of the changes in lipid peroxidation and activity of Na+/K+-ATPase in the brain of the aged rats in the conditions of two-vessel cerebral ischemia/reperfusion.] / 2019 / PubMed
• Exercise training initiated at old stage of lifespan attenuates aging-and ovariectomy-induced cardiac and renal oxidative stress: Role of baroreflex. / 09.2019 / PubMed / Full text
• Tris(1,3-dichloro-2-propyl) phosphate accelerated the aging process induced by the 4-hydroxynon-2-enal response to reactive oxidative species in Caenorhabditis elegans. / 03.2019 / PubMed / Full text
• Physical Exercise Attenuates Oxidative Stress and Morphofunctional Cerebellar Damages Induced by the Ethanol Binge Drinking Paradigm from Adolescence to Adulthood in Rats. / 2019 / PubMed / Full text
• [Effect of cryopreserved cord blood nucleated cells on course of pathological processes in progressive aging of brain (experimental study).] / 2018 / PubMed
• Analysis of Plasma MicroRNAs as Predictors and Biomarkers of Aging and Frailty in Humans. / 2018 / PubMed / Full text
• ERCC1-deficient cells and mice are hypersensitive to lipid peroxidation. / 20.08.2018 / PubMed / Full text
• Antioxidant action of grape seed polyphenols and aerobic exercise in improving neuronal number in the hippocampus is associated with decrease in lipid peroxidation and hydrogen peroxide in adult and middle-aged rats. / 01.2018 / PubMed / Full text
• The antioxidative and anti-aging effects of acidic- and alkalic-extractable mycelium polysaccharides by Agrocybe aegerita (Brig.) Sing. / 01.2018 / PubMed / Full text

MFN2

• Thioredoxin protects mitochondrial structure, function and biogenesis in myocardial ischemia-reperfusion via redox-dependent activation of AKT-CREB- PGC1α pathway in aged mice. / 13.10.2020 / PubMed / Full text
• MFN2 contributes to metabolic disorders and inflammation in the aging of rat chondrocytes and osteoarthritis. / 08.2020 / PubMed / Full text
• Mitofusin 2 plays a role in oocyte and follicle development, and is required to maintain ovarian follicular reserve during reproductive aging. / 16.06.2019 / PubMed / Full text
• Mitochondrial Quality Control in Aging and Heart Failure: Influence of Ketone Bodies and Mitofusin-Stabilizing Peptides. / 2019 / PubMed / Full text
• Low MFN2 expression related to ageing in granulosa cells is associated with assisted reproductive technology outcome. / 02.2019 / PubMed / Full text
• Loss of sirtuin 1 and mitofusin 2 contributes to enhanced ischemia/reperfusion injury in aged livers. / 08.2018 / PubMed / Full text
• Increased Degradation Rates in the Components of the Mitochondrial Oxidative Phosphorylation Chain in the Cerebellum of Old Mice. / 2018 / PubMed / Full text
• Slower Dynamics and Aged Mitochondria in Sporadic Alzheimer's Disease. / 2017 / PubMed / Full text
• Dietary supplementation with acetyl-l-carnitine counteracts age-related alterations of mitochondrial biogenesis, dynamics and antioxidant defenses in brain of old rats. / 11.2017 / PubMed / Full text

TSPO

• Age and Sex Influence the Neuro-inflammatory Response to a Peripheral Acute LPS Challenge. / 2019 / PubMed / Full text
• Upregulation of cannabinoid receptor type 2, but not TSPO, in senescence-accelerated neuroinflammation in mice: a positron emission tomography study. / 10.11.2019 / PubMed / Full text
• Effects of age, BMI and sex on the glial cell marker [[TSPO]] - a multicentre [ C]PBR28 HRRT PET study. / 10.2019 / PubMed / Full text
• Concentration, distribution, and influence of aging on the 18 kDa translocator protein in human brain: Implications for brain imaging studies. / 05.2020 / PubMed / Full text
• Microglial response to increasing amyloid load saturates with aging: a longitudinal dual tracer in vivo μPET-study. / 06.11.2018 / PubMed / Full text
• Age Influences Microglial Activation After Cuprizone-Induced Demyelination. / 2018 / PubMed / Full text
• [[TSPO]] ligand PK11195 improves Alzheimer-related outcomes in aged female 3xTg-AD mice. / 14.09.2018 / PubMed / Full text
• Imaging studies of the HIV-infected brain. / 2018 / PubMed / Full text
• Steroidogenic abnormalities in translocator protein knockout mice and significance in the aging male. / 02.01.2018 / PubMed / Full text

XBP1

• Age-dependent impairment of adipose-derived stem cells isolated from horses. / 03.01.2020 / PubMed / Full text
• Effects of a resistance-training programme on endoplasmic reticulum unfolded protein response and mitochondrial functions in PBMCs from elderly subjects. / 08.2019 / PubMed / Full text
• [Protective effect of Wuzi Yanzong recipe on testicular germ cell apoptosis in natural ageing rats through endoplasmic reticulum stress]. / 10.2018 / PubMed / Full text
• Protective effect of Wuzi Yanzong recipe on testicular dysfunction through inhibition of germ cell apoptosis in ageing rats via endoplasmic reticulum stress. / 03.2019 / PubMed / Full text
• Loss of XBP1 accelerates age-related decline in retinal function and neurodegeneration. / 04.04.2018 / PubMed / Full text
• A decay of the adaptive capacity of the unfolded protein response exacerbates Alzheimer's disease. / 03.2018 / PubMed / Full text
• Amyloid-β42 clearance and neuroprotection mediated by X-box binding protein 1 signaling decline with aging in the Drosophila brain. / 12.2017 / PubMed / Full text
• Ageing sensitized by iPLA β deficiency induces liver fibrosis and intestinal atrophy involving suppression of homeostatic genes and alteration of intestinal lipids and bile acids. / 12.2017 / PubMed / Full text
• ER stress and distinct outputs of the IRE1α RNase control proliferation and senescence in response to oncogenic Ras. / 12.09.2017 / PubMed / Full text

BCL2

• Soy isoflavones protect against oxidative stress and diminish apoptosis in ovary of middle-aged female rats. / 07.2019 / PubMed / Full text
• Nrdp1 is involved in hippocampus apoptosis in cardiopulmonary bypass-induced cognitive dysfunction via the regulation of ErbB3 protein levels. / 04.2019 / PubMed / Full text
• Self-Digestion for Lifespan Extension: Enhanced Autophagy Delays Aging. / 16.08.2018 / PubMed / Full text
• Disruption of the beclin 1-BCL2 autophagy regulatory complex promotes longevity in mice. / 06.2018 / PubMed / Full text
• Sestrins are differentially expressed with age in the skeletal muscle of men: A cross-sectional analysis. / 09.2018 / PubMed / Full text
• Autophagy regulates the degeneration of the auditory cortex through the AMPK-mTOR-ULK1 signaling pathway. / 04.2018 / PubMed / Full text
• The effect of ARC ablation on skeletal muscle morphology, function, and apoptotic signaling during aging. / 01.2018 / PubMed / Full text
• High-Throughput Functional Genetic and Compound Screens Identify Targets for Senescence Induction in Cancer. / 17.10.2017 / PubMed / Full text

CDKN2A

• Association between Nrf2 and CDKN2A expression in patients with end-stage renal disease: a pilot study. / 13.07.2020 / PubMed / Full text
• Analysis of somatic mutations identifies signs of selection during in vitro aging of primary dermal fibroblasts. / 12.2019 / PubMed / Full text
• Analysis of the putative tumor suppressor gene cdkn2ab in pigment cells and melanoma of Xiphophorus and medaka. / 03.2019 / PubMed / Full text
• In vitro behavior and UV response of melanocytes derived from carriers of [[CDKN2A]] mutations and MC1R variants. / 03.2019 / PubMed / Full text
• Endothelial PPARγ (Peroxisome Proliferator-Activated Receptor-γ) Is Essential for Preventing Endothelial Dysfunction With Aging. / 07.2018 / PubMed / Full text
• Upregulation of lactate-inducible snail protein suppresses oncogene-mediated senescence through p16 inactivation. / 26.02.2018 / PubMed / Full text
• Cellular aging dynamics after acute malaria infection: A 12-month longitudinal study. / 02.2018 / PubMed / Full text
• ARID1A suppresses malignant transformation of human pancreatic cells via mediating senescence-associated miR-503/[[CDKN2A]] regulatory axis. / 18.11.2017 / PubMed / Full text

CFTR

• Exercise Physiology Across the Lifespan in Cystic Fibrosis. / 2019 / PubMed / Full text
• Reduced expression of the Ion channel CFTR contributes to airspace enlargement as a consequence of aging and in response to cigarette smoke in mice. / 02.09.2019 / PubMed / Full text
• Is cellular senescence involved in cystic fibrosis? / 14.02.2019 / PubMed / Full text
• Autophagy delays progression of the two most frequent human monogenetic lethal diseases: cystic fibrosis and Wilson disease. / 19.12.2018 / PubMed / Full text
• The Clinical Biology of Cystic Fibrosis Transmembrane Regulator Protein: Its Role and Function in Extrapulmonary Disease. / 03.2019 / PubMed / Full text
• [Ageing with cystic fibrosis: Classical and emerging comorbidities in adults with cystic fibrosis]. / 10.2018 / PubMed / Full text
• A review of inflammatory mechanism in airway diseases. / 01.2019 / PubMed / Full text
• Up-to-date and projected estimates of survival for people with cystic fibrosis using baseline characteristics: A longitudinal study using UK patient registry data. / 03.2018 / PubMed / Full text

COMT

• The geriatric pain experience in mice: intact cutaneous thresholds but altered responses to tonic and chronic pain. / 05.2020 / PubMed / Full text
• A candidate gene study of risk for dementia in older, postmenopausal women: Results from the Women's Health Initiative Memory Study. / 05.2019 / PubMed / Full text
• Frontoparietal cortical thickness mediates the effect of COMT Val Met polymorphism on age-associated executive function. / 01.2019 / PubMed / Full text
• [MELATONIN: THE POSSIBILITY TO ANALYSE THE MARKER OF AGE-RELATED PATHOLOGY IN THE BUCCAL EPITHELIUM AND URINE]. / 2017 / PubMed
• The Moderating Role of COMT and BDNF Polymorphisms on Transfer Effects Following Multi- and Single-Domain Cognitive Training Among Community-Dwelling Shanghainese Older Adults. / 2018 / PubMed / Full text
• Genetic Risk for Age-Related Cognitive Impairment Does Not Predict Cognitive Performance in Middle Age. / 2018 / PubMed / Full text
• Dopamine-Related Genotypes and Physical Activity Change During an Intervention: The Lifestyle Interventions and Independence for Elders Study. / 07.2018 / PubMed / Full text
• Genetic Biomarkers on Age-Related Cognitive Decline. / 2017 / PubMed / Full text

CTRL

• Aging reduces the maximal level of peripheral fatigue tolerable and impairs exercise capacity. / 01.12.2020 / PubMed / Full text
• miR-146a Plasma Levels Are Not Altered in Alzheimer's Disease but Correlate With Age and Illness Severity. / 2019 / PubMed / Full text
• Centrally-mediated regulation of peripheral fatigue during knee extensor exercise and consequences on the force-duration relationship in older men. / 06.2020 / PubMed / Full text
• Non-linear registration improves statistical power to detect hippocampal atrophy in aging and dementia. / 2019 / PubMed / Full text
• Plyometric exercise improves jumping performance and skeletal muscle contractile properties in seniors. / 01.03.2019 / PubMed / Full text
• Soy isoflavones protect against oxidative stress and diminish apoptosis in ovary of middle-aged female rats. / 07.2019 / PubMed / Full text
• Heterogeneity of Thyroid Function and Impact of Peripheral Thyroxine Deiodination in Centenarians and Semi-Supercentenarians: Association With Functional Status and Mortality. / 16.05.2019 / PubMed / Full text
• Evaluation of Lymphocyte Response to the Induced Oxidative Stress in a Cohort of Ageing Subjects, including Semisupercentenarians and Their Offspring. / 2018 / PubMed / Full text

CXCL12

• Co-option of Neutrophil Fates by Tissue Environments. / 25.11.2020 / PubMed / Full text
• Heme oxygenase-1 deficiency triggers exhaustion of hematopoietic stem cells. / 05.02.2020 / PubMed / Full text
• Global Transcriptomic Profiling of the Bone Marrow Stromal Microenvironment during Postnatal Development, Aging, and Inflammation. / 03.12.2019 / PubMed / Full text
• Long-term repopulation of aged bone marrow stem cells using young Sca-1 cells promotes aged heart rejuvenation. / 12.2019 / PubMed / Full text
• Reducing CXCR4 Resulted in Impairing Proliferation and Promoting Aging. / 2018 / PubMed / Full text
• Quantitative spatial analysis of haematopoiesis-regulating stromal cells in the bone marrow microenvironment by 3D microscopy. / 28.06.2018 / PubMed / Full text
• Tumor microenvironment in functional adrenocortical adenomas: immune cell infiltration in cortisol-producing adrenocortical adenoma. / 07.2018 / PubMed / Full text
• Systemic analysis of gene expression profiles in porcine granulosa cells during aging. / 14.11.2017 / PubMed / Full text

ERF

• Angiotensin-Converting Enzyme Gene D/I Polymorphism in Relation to Endothelial Function and Endothelial-Released Factors in Chinese Women. / 2020 / PubMed / Full text
• Projections of Ambient Temperature- and Air Pollution-Related Mortality Burden Under Combined Climate Change and Population Aging Scenarios: a Review. / 09.2020 / PubMed / Full text
• Exome Sequencing Analysis Identifies Rare Variants in [i]ATM[/i] and [i]RPL8[/i] That Are Associated With Shorter Telomere Length. / 2020 / PubMed / Full text
• The ERF transcription factor EPI1 is a negative regulator of dark-induced and jasmonate-stimulated senescence in [i]Arabidopsis[/i]. / 2016 / PubMed / Full text
• Transcriptional regulation of Lonicera japonica Thunb. during flower development as revealed by comprehensive analysis of transcription factors. / 14.05.2019 / PubMed / Full text
• Impact of Alternatively Polyadenylated Isoforms of ETHYLENE RESPONSE FACTOR4 with Activator and Repressor Function on Senescence in [i]Arabidopsis thaliana[/i] L. / 28.01.2019 / PubMed / Full text
• Transcriptome analysis of leaf senescence in red clover ([i]Trifolium pratense[/i] L.). / 09.2018 / PubMed / Full text
• Molecular and functional characterization of ShNAC1, an NAC transcription factor from Solanum habrochaites. / 06.2018 / PubMed / Full text

G6PD

• G6PD overexpression protects from oxidative stress and age-related hearing loss. / 22.11.2020 / PubMed / Full text
• The Sickle Effect: The Silent Titan Affecting Glycated Hemoglobin Reliability. / 12.08.2020 / PubMed / Full text
• DNA damage and synaptic and behavioural disorders in glucose-6-phosphate dehydrogenase-deficient mice. / 01.2020 / PubMed / Full text
• JNK modifies neuronal metabolism to promote proteostasis and longevity. / 06.2019 / PubMed / Full text
• Antioxidant SMe1EC2 modulates pentose phosphate pathway and glutathione-dependent enzyme activities in tissues of aged diabetic rats. / 12.2017 / PubMed / Full text
• Detection of a novel, primate-specific 'kill switch' tumor suppression mechanism that may fundamentally control cancer risk in humans: an unexpected twist in the basic biology of TP53. / 11.2018 / PubMed / Full text
• Safety of Single-Dose Primaquine in G6PD-Deficient and G6PD-Normal Males in Mali Without Malaria: An Open-Label, Phase 1, Dose-Adjustment Trial. / 28.03.2018 / PubMed / Full text
• Effect of age, period and birth-cohort on the frequency of glucose-6-phosphate dehydrogenase deficiency in Sardinian adults. / 02.2018 / PubMed / Full text

HDAC3

• Histone deacetylase-3: Friend and foe of the brain. / 07.2020 / PubMed / Full text
• Loss of HDAC3 contributes to meiotic defects in aged oocytes. / 12.2019 / PubMed / Full text
• HDAC3-Mediated Repression of the [i]Nr4a[/i] Family Contributes to Age-Related Impairments in Long-Term Memory. / 19.06.2019 / PubMed / Full text
• Budesonide, Aclidinium and Formoterol in combination limit inflammaging processes in bronchial epithelial cells exposed to cigarette smoke. / 04.2019 / PubMed / Full text
• HDAC3 Regulates the Transition to the Homeostatic Myelinating Schwann Cell State. / 04.12.2018 / PubMed / Full text
• Novel anti-aging gene NM_026333 contributes to proton-induced aging via NCX1-pathway. / 12.2018 / PubMed / Full text
• Epigenetic regulation of the circadian gene Per1 contributes to age-related changes in hippocampal memory. / 20.08.2018 / PubMed / Full text
• Histone deacetylase 1 expression is inversely correlated with age in the short-lived fish Nothobranchius furzeri. / 09.2018 / PubMed / Full text

IL10

• The beneficial effect of physical exercise on inflammatory makers in older individuals. / 06.06.2020 / PubMed / Full text
• Astrocyte senescence may drive alterations in GFAPα, CDKN2A p14 , and TAU3 transcript expression and contribute to cognitive decline. / 10.2019 / PubMed / Full text
• Dietary Spray-Dried Porcine Plasma Prevents Cognitive Decline in Senescent Mice and Reduces Neuroinflammation and Oxidative Stress. / 01.02.2020 / PubMed / Full text
• Age-dependent hepatic alterations induced by a high-fat high-fructose diet. / 05.2019 / PubMed / Full text
• [i]Lactobacillus paracasei[/i] PS23 decelerated age-related muscle loss by ensuring mitochondrial function in SAMP8 mice. / 29.01.2019 / PubMed / Full text
• Inflammatory cytokines and immune system modulation by aerobic versus resisted exercise training for elderly. / 03.2018 / PubMed / Full text
• Pentoxifylline, dexamethasone and azithromycin demonstrate distinct age-dependent and synergistic inhibition of TLR- and inflammasome-mediated cytokine production in human newborn and adult blood in vitro. / 2018 / PubMed / Full text
• Deficiency in Protein Tyrosine Phosphatase PTP1B Shortens Lifespan and Leads to Development of Acute Leukemia. / 01.01.2018 / PubMed / Full text

INS

• Melatonin protects INS-1 pancreatic β-cells from apoptosis and senescence induced by glucotoxicity and glucolipotoxicity. / 03.07.2020 / PubMed / Full text
• Nicotine triggers islet β cell senescence to facilitate the progression of type 2 diabetes. / 08.2020 / PubMed / Full text
• Reducing INS-IGF1 signaling protects against non-cell autonomous vesicle rupture caused by SNCA spreading. / 05.2020 / PubMed / Full text
• Insulin-like peptides and the mTOR-TFEB pathway protect [i]Caenorhabditis elegans[/i] hermaphrodites from mating-induced death. / 08.07.2019 / PubMed / Full text
• The Maghreb demographic transition: Tunisia case study. / 10-11.2018 / PubMed
• Temporal pattern of neuronal insulin release during Caenorhabditis elegans aging: Role of redox homeostasis. / 02.2019 / PubMed / Full text
• A functional study of all 40 [i]Caenorhabditis elegans[/i] insulin-like peptides. / 26.10.2018 / PubMed / Full text
• The anti-aging protein Klotho is induced by GABA therapy and exerts protective and stimulatory effects on pancreatic beta cells. / 02.12.2017 / PubMed / Full text

KRAS

• Chemical Pathology of Homocysteine VIII. Effects of Tocotrienol, Geranylgeraniol, and Squalene on Thioretinaco Ozonide, Mitochondrial Permeability, and Oxidative Phosphorylation in Arteriosclerosis, Cancer, Neurodegeneration and Aging. / 09.2020 / PubMed
• Senescence-Induced Vascular Remodeling Creates Therapeutic Vulnerabilities in Pancreas Cancer. / 16.04.2020 / PubMed / Full text
• Oncogenic mutations in histologically normal endometrium: the new normal? / 10.2019 / PubMed / Full text
• Inhibition of ERK1/2 in cancer-associated pancreatic stellate cells suppresses cancer-stromal interaction and metastasis. / 27.05.2019 / PubMed / Full text
• Comprehensive transcriptome profiling in elderly cancer patients reveals aging-altered immune cells and immune checkpoints. / 01.04.2019 / PubMed / Full text
• O-GlcNAcylation is required for mutant KRAS-induced lung tumorigenesis. / 01.11.2018 / PubMed / Full text
• E47 Governs the MYC-CDKN1B/p27 -RB Network to Growth Arrest PDA Cells Independent of CDKN2A/p16 and Wild-Type p53. / 2018 / PubMed / Full text
• ARID1A suppresses malignant transformation of human pancreatic cells via mediating senescence-associated miR-503/[[CDKN2A]] regulatory axis. / 18.11.2017 / PubMed / Full text

MMP2

• Cellular retinoic acid binding protein-II expression and its potential role in skin aging. / 18.03.2019 / PubMed / Full text
• [Effect of saponins extracted from Panax japonicas on inhibiting myocardial fibrosis by TGF-β1/Smad3 signaling pathway in aging rats]. / 11.2018 / PubMed / Full text
• TMT-Based Quantitative Proteomic Analysis Reveals Proteomic Changes Involved in Longevity. / 07.2019 / PubMed / Full text
• MicroRNA-338-5p plays a tumor suppressor role in glioma through inhibition of the MAPK-signaling pathway by binding to FOXD1. / 12.2018 / PubMed / Full text
• PM2.5 promotes abdominal aortic aneurysm formation in angiotensin Ⅱ-infused apoe-/- mice. / 08.2018 / PubMed / Full text
• Activation of DNA demethylases attenuates aging-associated arterial stiffening and hypertension. / 08.2018 / PubMed / Full text
• MMP2-A2M interaction increases ECM accumulation in aged rat kidney and its modulation by calorie restriction. / 19.01.2018 / PubMed / Full text
• Systemic analysis of gene expression profiles in porcine granulosa cells during aging. / 14.11.2017 / PubMed / Full text

MTOR

• The roles of MTOR and miRNAs in endothelial cell senescence. / 10.2020 / PubMed / Full text
• Autophagy drives fibroblast senescence through MTORC2 regulation. / 11.2020 / PubMed / Full text
• The GID ubiquitin ligase complex is a regulator of AMPK activity and organismal lifespan. / 09.2020 / PubMed / Full text
• The double-edged sword of MTOR in autophagy deficiency induced-liver injury and tumorigenesis. / 09.2019 / PubMed / Full text
• A large-scale CRISPR screen and identification of essential genes in cellular senescence bypass. / 20.06.2019 / PubMed / Full text
• Effect of young exosomes injected in aged mice. / 2018 / PubMed / Full text
• Inhibition of glioma growth by flavokawain B is mediated through endoplasmic reticulum stress induced autophagy. / 2018 / PubMed / Full text
• Endothelial replicative senescence delayed by the inhibition of MTORC1 signaling involves MicroRNA-107. / 08.2018 / PubMed / Full text

MYB

• Transcriptome profiling of postharvest shoots identifies PheNAP2- and PheNAP3-promoted shoot senescence. / 01.12.2019 / PubMed / Full text
• Systematic Analysis of MYB Family Genes in Potato and Their Multiple Roles in Development and Stress Responses. / 30.07.2019 / PubMed / Full text
• Transcriptional regulation of Lonicera japonica Thunb. during flower development as revealed by comprehensive analysis of transcription factors. / 14.05.2019 / PubMed / Full text
• Transgenic expression of rice MYB102 (OsMYB102) delays leaf senescence and decreases abiotic stress tolerance in Arabidopsis thaliana. / 11.2019 / PubMed / Full text
• The WRKY transcription factor GhWRKY27 coordinates the senescence regulatory pathway in upland cotton (Gossypium hirsutum L.). / 29.03.2019 / PubMed / Full text
• Rice transcription factor OsMYB102 delays leaf senescence by down-regulating abscisic acid accumulation and signaling. / 09.05.2019 / PubMed / Full text
• Transcriptome analysis of leaf senescence in red clover ([i]Trifolium pratense[/i] L.). / 09.2018 / PubMed / Full text
• The Direct Involvement of Dark-Induced Tic55 Protein in Chlorophyll Catabolism and Its Indirect Role in the MYB108-NAC Signaling Pathway during Leaf Senescence in [i]Arabidopsis thaliana[/i]. / 23.06.2018 / PubMed / Full text

NQO1

• Augmentation of cellular NAD by NQO1 enzymatic action improves age-related hearing impairment. / 10.2019 / PubMed / Full text
• Well-aging: A new strategy for skin homeostasis under multi-stressed conditions. / 02.2020 / PubMed / Full text
• Limitations to adaptive homeostasis in an hyperoxia-induced model of accelerated ageing. / 06.2019 / PubMed / Full text
• Link between cardiac function and the antioxidative defense mechanism in aged rats. / 11.06.2019 / PubMed / Full text
• [Protective effect of Wuzi Yanzong recipe on testicular DNA oxidative damage in natural ageing rats]. / 07.2018 / PubMed / Full text
• Benefits of Caloric Restriction in Longevity and Chemical-Induced Tumorigenesis Are Transmitted Independent of NQO1. / 16.01.2019 / PubMed / Full text
• Overexpression of CYB5R3 and NQO1, two NAD -producing enzymes, mimics aspects of caloric restriction. / 08.2018 / PubMed / Full text
• Sargassum fusiforme Polysaccharide Rejuvenat es the Small Intestine in Mice Through Altering its Physiol ogy and Gut Microbiota Composition. / 2017 / PubMed / Full text

PIP

• Potentially inappropriate prescriptions according to explicit and implicit criteria in patients with multimorbidity and polypharmacy. MULTIPAP: A cross-sectional study. / 2020 / PubMed / Full text
• Quality of prescribing predicts hospitalisation in octogenarians: life and living in advanced age: a cohort study in New Zealand (LiLACS NZ). / 19.12.2019 / PubMed / Full text
• A Systematic Review of Studies of the STOPP/START 2015 and American Geriatric Society Beers 2015 Criteria in Patients ≥ 65 Years. / 2019 / PubMed / Full text
• Intracellular cholesterol stimulates ENaC by interacting with phosphatidylinositol‑4,5‑bisphosphate and mediates cyclosporine A-induced hypertension. / 01.07.2019 / PubMed / Full text
• Medicinal products for geriatric patients in Germany : Current status of regulatory requirements and clinical reality. / 07.2020 / PubMed / Full text
• Patterns of multi-morbidity and prediction of hospitalisation and all-cause mortality in advanced age. / 01.03.2018 / PubMed / Full text
• A Pharmacist-Led Program to Evaluate and Reduce Polypharmacy and Potentially Inappropriate Prescribing in Older HIV-Positive Patients. / 12.2017 / PubMed / Full text
• Prevalence and predictors of potentially inappropriate prescribing of central nervous system and psychotropic drugs among elderly patients: A national population study in Korea. / 01.2018 / PubMed / Full text

PML

• Progressive multifocal leukoencephalopathy in dimethyl fumarate-treated multiple sclerosis patients. / 18.08.2020 / PubMed / Full text
• PML2-mediated thread-like nuclear bodies mark late senescence in Hutchinson-Gilford progeria syndrome. / 06.2020 / PubMed / Full text
• Trophoblast type-specific expression of senescence markers in the human placenta. / 15.09.2019 / PubMed / Full text
• PML nuclear bodies are recruited to persistent DNA damage lesions in an RNF168-53BP1 dependent manner and contribute to DNA repair. / 06.2019 / PubMed / Full text
• Nuclear Nox4 interaction with prelamin A is associated with nuclear redox control of stem cell aging. / 24.10.2018 / PubMed / Full text
• Aging and lymphocyte changes by immunomodulatory therapies impact PML risk in multiple sclerosis patients. / 07.2018 / PubMed / Full text
• SOCS1 regulates senescence and ferroptosis by modulating the expression of p53 target genes. / 28.10.2017 / PubMed / Full text
• Age as a risk factor for early onset of natalizumab-related progressive multifocal leukoencephalopathy. / 10.2017 / PubMed / Full text

S100A9

• Cigarette smoke induction of S100A9 contributes to chronic obstructive pulmonary disease. / 23.09.2020 / PubMed / Full text
• Modulation of KDM1A with vafidemstat rescues memory deficit and behavioral alterations. / 2020 / PubMed / Full text
• Cellular senescence induced by S100A9 in mesenchymal stromal cells through NLRP3 inflammasome activation. / 14.11.2019 / PubMed / Full text
• S100A9 extends lifespan in insulin deficiency. / 07.08.2019 / PubMed / Full text
• S100A8, which increases with age, induces cellular senescence-like changes in bovine oviduct epithelial cells. / 09.2019 / PubMed / Full text
• Fetal articular cartilage regeneration versus adult fibrocartilaginous repair: secretome proteomics unravels molecular mechanisms in an ovine model. / 06.07.2018 / PubMed / Full text
• Intranasally Administered S100A9 Amyloids Induced Cellular Stress, Amyloid Seeding, and Behavioral Impairment in Aged Mice. / 20.06.2018 / PubMed / Full text
• S100A9 Protein Aggregates Boost Hippocampal Glutamate Modifying Monoaminergic Neurochemistry: A Glutamate Antibody Sensitive Outcome on Alzheimer-like Memory Decline. / 21.03.2018 / PubMed / Full text

SFN

• The phytoprotective agent sulforaphane prevents inflammatory degenerative diseases and age-related pathologies via Nrf2-mediated hormesis. / 04.11.2020 / PubMed / Full text
• Multi-Omic Analysis Reveals Different Effects of Sulforaphane on the Microbiome and Metabolome in Old Compared to Young Mice. / 29.09.2020 / PubMed / Full text
• Sulforaphane controls the release of paracrine factors by keratinocytes and thus mitigates particulate matter-induced premature skin aging by suppressing melanogenesis and maintaining collagen homeostasis. / 10.2020 / PubMed / Full text
• Sulforaphane Inhibits Autophagy and Induces Exosome-Mediated Paracrine Senescence via Regulating mTOR/TFE3. / 07.2020 / PubMed / Full text
• Effects of sulforaphane on D-galactose-induced liver aging in rats: Role of keap-1/nrf-2 pathway. / 15.07.2019 / PubMed / Full text
• Sulforaphane - role in aging and neurodegeneration. / 10.2019 / PubMed / Full text
• The secretory phenotype of senescent astrocytes isolated from Wistar newborn rats changes with anti-inflammatory drugs, but does not have a short-term effect on neuronal mitochondrial potential. / 10.2018 / PubMed / Full text
• Sulforaphane reactivates cellular antioxidant defense by inducing Nrf2/ARE/Prdx6 activity during aging and oxidative stress. / 26.10.2017 / PubMed / Full text

SST

• The distance to death perceptions of older adults explain why they age in place: A theoretical examination. / 09.2020 / PubMed / Full text
• Population Segmentation Based on Healthcare Needs: Validation of a Brief Clinician-Administered Tool. / 30.06.2020 / PubMed / Full text
• Examination on how emotion regulation mediates the relationship between future time perspective and well-being: a counter-evidence to the socioemotional selectivity theory. / 03.2020 / PubMed / Full text
• Shear-Wave and Strain Ultrasound Elastography of the Supraspinatus and Infraspinatus Tendons in Patients with Idiopathic Adhesive Capsulitis of the Shoulder: A Prospective Case-Control Study. / 07.2019 / PubMed / Full text
• Counting down while time flies: implications of age-related time acceleration for goal pursuit across adulthood. / 04.2019 / PubMed / Full text
• Relative costs and benefits of alternative reproductive phenotypes at different temperatures - genotype-by-environment interactions in a sexually selected trait. / 11.07.2018 / PubMed / Full text
• Climate change and functional traits affect population dynamics of a long-lived seabird. / 07.2018 / PubMed / Full text
• Influence of season, age and management on scrotal thermal profile in Murrah bulls using scrotal infrared digital thermography. / 12.2017 / PubMed / Full text

STAT1

• STAT1-p53-p21axis-dependent stress-induced progression of chronic nephrosis in adriamycin-induced mouse model. / 08.2020 / PubMed / Full text
• Age-Dependent and -Independent Effects of Perivascular Adipose Tissue and Its Paracrine Activities during Neointima Formation. / 31.12.2019 / PubMed / Full text
• Legumain-deficient macrophages promote senescence of tumor cells by sustaining JAK1/STAT1 activation. / 01.03.2020 / PubMed / Full text
• Inflammaging: Age and Systemic, Cellular, and Nuclear Inflammatory Biology in Older Adults. / 04.10.2019 / PubMed / Full text
• Age-specific changes in the molecular phenotype of patients with moderate-to-severe atopic dermatitis. / 07.2019 / PubMed / Full text
• Identification of key genes and transcription factors in aging mesenchymal stem cells by DNA microarray data. / 15.04.2019 / PubMed / Full text
• Transcriptome analysis reveals immune-related gene expression changes with age in giant panda ([i]Ailuropoda melanoleuca[/i]) blood. / 14.01.2019 / PubMed / Full text
• A tyrosine kinase-activating variant Asn666Ser in PDGFRB causes a progeria-like condition in the severe end of Penttinen syndrome. / 04.2019 / PubMed / Full text

ULK1

• [Molecular mechanisms of mycelium of Cordyceps sinensis ameliorating renal tubular epithelial cells aging induced by D-galactose via inhibiting autophagy-related AMPK/ULK1 signaling activation]. / 03.2019 / PubMed / Full text
• The autophagy-related gene [i]Atg101[/i] in [i]Drosophila[/i] regulates both neuron and midgut homeostasis. / 05.04.2019 / PubMed / Full text
• Hyperoside attenuates renal aging and injury induced by D-galactose via inhibiting AMPK-ULK1 signaling-mediated autophagy. / 24.12.2018 / PubMed / Full text
• Sarcopenia targeting with autophagy mechanism by exercise. / 01.2019 / PubMed / Full text
• Young plasma attenuates age-dependent liver ischemia reperfusion injury. / 02.2019 / PubMed / Full text
• Depletion of gamma-glutamylcyclotransferase in cancer cells induces autophagy followed by cellular senescence. / 2018 / PubMed / Full text
• Responders and non-responders to influenza vaccination: A DNA methylation approach on blood cells. / 05.2018 / PubMed / Full text
• Autophagy regulates the degeneration of the auditory cortex through the AMPK-mTOR-ULK1 signaling pathway. / 04.2018 / PubMed / Full text

ATF6

• Cellular proteostasis decline in human senescence. / 30.11.2020 / PubMed / Full text
• Impact of endoplasmic reticulum stress on oocyte aging mechanisms. / 01.08.2020 / PubMed / Full text
• ER stress activates immunosuppressive network: implications for aging and Alzheimer's disease. / 05.2020 / PubMed / Full text
• Towards Age-Related Anti-Inflammatory Therapy: Klotho Suppresses Activation of ER and Golgi Stress Response in Senescent Monocytes. / 21.01.2020 / PubMed / Full text
• Reaction to Endoplasmic Reticulum Stress [i]via[/i] ATF6 in Amyotrophic Lateral Sclerosis Deteriorates With Aging. / 2019 / PubMed / Full text
• [Protective effect of Wuzi Yanzong recipe on testicular germ cell apoptosis in natural ageing rats through endoplasmic reticulum stress]. / 10.2018 / PubMed / Full text
• PGC-1α in aging and lifelong exercise training-mediated regulation of UPR in mouse liver. / 11.2017 / PubMed / Full text

ATG5

• Autophagy and heat-shock response impair stress granule assembly during cellular senescence. / 12.2020 / PubMed / Full text
• Effects of MUL1 and PARKIN on the circadian clock, brain and behaviour in Drosophila Parkinson's disease models. / 28.05.2019 / PubMed / Full text
• Lifelong Football Training: Effects on Autophagy and Healthy Longevity Promotion. / 2019 / PubMed / Full text
• The ATG5-binding and coiled coil domains of ATG16L1 maintain autophagy and tissue homeostasis in mice independently of the WD domain required for LC3-associated phagocytosis. / 04.2019 / PubMed / Full text
• Inhibition of glioma growth by flavokawain B is mediated through endoplasmic reticulum stress induced autophagy. / 2018 / PubMed / Full text
• Carvacrol nanoemulsion evokes cell cycle arrest, apoptosis induction and autophagy inhibition in doxorubicin resistant-A549 cell line. / 2018 / PubMed / Full text
• Compromised autophagy precedes meniscus degeneration and cartilage damage in mice. / 11.2017 / PubMed / Full text

BCR

• The presence of CLL-associated stereotypic B cell receptors in the normal BCR repertoire from healthy individuals increases with age. / 2019 / PubMed / Full text
• Crucial Role of Increased Arid3a at the Pre-B and Immature B Cell Stages for B1a Cell Generation. / 2019 / PubMed / Full text
• Effect of Age on NK Cell Compartment in Chronic Myeloid Leukemia Patients Treated With Tyrosine Kinase Inhibitors. / 2018 / PubMed / Full text
• B cell responses to apoptotic cells in MFG-E8-/- mice. / 2018 / PubMed / Full text
• Early Generated B-1-Derived B Cells Have the Capacity To Progress To Become Mantle Cell Lymphoma-like Neoplasia in Aged Mice. / 15.07.2018 / PubMed / Full text
• Mean residual life regression with functional principal component analysis on longitudinal data for dynamic prediction. / 12.2018 / PubMed / Full text
• NLR Nod1 signaling promotes survival of BCR-engaged mature B cells through up-regulated Nod1 as a positive outcome. / 02.10.2017 / PubMed / Full text

CCL11

• CCL-11 or Eotaxin-1: An Immune Marker for Ageing and Accelerated Ageing in Neuro-Psychiatric Disorders. / 02.09.2020 / PubMed / Full text
• Young bone marrow transplantation preserves learning and memory in old mice. / 2019 / PubMed / Full text
• [The role of «Youth and aging proteins» in essential hypertension pathogenesis.] / 2018 / PubMed
• Association between plasma CCL11 (eotaxin-1) and cognitive status in older adults: Differences between rural and urban dwellers. / 11.2018 / PubMed / Full text
• Inflammaging impairs peripheral nerve maintenance and regeneration. / 12.2018 / PubMed / Full text
• Stem Cell-Induced Pulp Regeneration Can Be Enhanced by Administration of CCL11-Neutralizing Antibody in the Ectopic Tooth Transplantation Model in the Aged Mice. / 02.2019 / PubMed / Full text
• Inflammatory chemokine eotaxin-1 is correlated with age in heroin dependent patients under methadone maintenance therapy. / 01.02.2018 / PubMed / Full text

CCL5

• CCL5 secreted by senescent theca-interstitial cells inhibits preantral follicular development via granulosa cellular apoptosis. / 12.2019 / PubMed / Full text
• Inflammatory markers and occurrence of falls: Bambuí Cohort Study of Aging. / 01.04.2019 / PubMed / Full text
• TMT-Based Quantitative Proteomic Analysis Reveals Proteomic Changes Involved in Longevity. / 07.2019 / PubMed / Full text
• Burn wounds in the young versus the aged patient display differential immunological responses. / 09.2018 / PubMed / Full text
• Urine Cytokine and Chemokine Levels Predict Urinary Tract Infection Severity Independent of Uropathogen, Urine Bacterial Burden, Host Genetics, and Host Age. / 09.2018 / PubMed / Full text
• Immune senescence and biomarkers profile of Bambuí aged population-based cohort. / 03.2018 / PubMed / Full text
• Predictive value of multiple cytokines and chemokines for mortality in an admixed population: 15-year follow-up of the Bambui-Epigen (Brazil) cohort study of aging. / 11.2017 / PubMed / Full text

CD19

• Sequential treatment with aT19 cells generates memory CAR-T cells and prolongs the lifespan of Raji-B-NDG mice. / 28.01.2020 / PubMed / Full text
• Stress-Induced Premature Senescence Promotes Proliferation by Activating the [i]SENEX[/i] and p16 /Retinoblastoma (Rb) Pathway in Diffuse Large B-Cell Lymphoma / 18.11.2019 / PubMed / Full text
• Effects of pepsin and pepstatin on reflux tonsil hypertrophy in vitro. / 2018 / PubMed / Full text
• Innate and adaptive immune dysregulation in critically ill ICU patients. / 05.07.2018 / PubMed / Full text
• Vitamin D levels correlate with lymphocyte subsets in elderly patients with age-related diseases. / 16.05.2018 / PubMed / Full text
• Normal variation of bone marrow B-cell precursors according to age - reference ranges for studies in myelodysplastic syndromes in Brazil. / 09.2018 / PubMed / Full text
• Altered marginal zone and innate-like B cells in aged senescence-accelerated SAMP8 mice with defective IgG1 responses. / 17.08.2017 / PubMed / Full text

CD63

• Cellular senescence contributes to age-dependent changes in circulating extracellular vesicle cargo and function. / 03.2020 / PubMed / Full text
• Exosomal Notch3 from high glucose-stimulated endothelial cells regulates vascular smooth muscle cells calcification/aging. / 01.09.2019 / PubMed / Full text
• Adiponectin promotes muscle regeneration through binding to T-cadherin. / 09.01.2019 / PubMed / Full text
• Exosomes from hyperglycemia-stimulated vascular endothelial cells contain versican that regulate calcification/senescence in vascular smooth muscle cells. / 2019 / PubMed / Full text
• The Aging Process Alters IL-1β and CD63 Levels Differently in Extracellular Vesicles Obtained from the Plasma and Cerebrospinal Fluid. / 2018 / PubMed / Full text
• miRNA in Circulating Microvesicles as Biomarkers for Age-Related Cognitive Decline. / 2017 / PubMed / Full text
• Circulating extracellular vesicles in the aging process: impact of aerobic exercise. / 03.2018 / PubMed / Full text

CDKN1A

• Involvement of CDKN1A (p21) in cellular senescence in response to heat and irradiation stress during preimplantation development. / 05.2020 / PubMed / Full text
• Chromatin remodeling factor BAZ1A regulates cellular senescence in both cancer and normal cells. / 15.07.2019 / PubMed / Full text
• Histone demethylase KDM6B regulates 1,25-dihydroxyvitamin D3-induced senescence in glioma cells. / 08.2019 / PubMed / Full text
• A Novel [i]Dnmt3a1[/i] Transcript Inhibits Adipogenesis. / 2018 / PubMed / Full text
• Altered modulation of lamin A/C-HDAC2 interaction and p21 expression during oxidative stress response in HGPS. / 10.2018 / PubMed / Full text
• Conditioned medium from stimulated macrophages inhibits growth but induces an inflammatory phenotype in breast cancer cells. / 10.2018 / PubMed / Full text
• DNA damage and neurodegenerative phenotypes in aged Ciz1 null mice. / 02.2018 / PubMed / Full text

CLOCK

• Investigating circadian clock gene expression in human tendon biopsies from acute exercise and immobilization studies. / 06.2019 / PubMed / Full text
• CLOCK gene polymorphisms and quality of aging in a cohort of nonagenarians - The MUGELLO Study. / 06.02.2019 / PubMed / Full text
• Is the aging human ovary still ticking?: Expression of clock-genes in luteinized granulosa cells of young and older women. / 21.11.2018 / PubMed / Full text
• Aging and chromatoid body assembly: Are these two physiological events linked? / 07.2018 / PubMed / Full text
• CIRCADIAN CLOCK-ASSOCIATED 1 Inhibits Leaf Senescence in [i]Arabidopsis[/i]. / 2018 / PubMed / Full text
• Circadian clocks: from stem cells to tissue homeostasis and regeneration. / 01.2018 / PubMed / Full text
• Female ClockΔ19/Δ19 mice are protected from the development of age-dependent cardiomyopathy. / 01.02.2018 / PubMed / Full text

CR1

• Single Nucleotide Polymorphisms in Alzheimer's Disease Risk Genes Are Associated with Intrinsic Connectivity in Middle Age. / 2020 / PubMed / Full text
• The whale shark genome reveals how genomic and physiological properties scale with body size. / 25.08.2020 / PubMed / Full text
• Mouse models of Alzheimer's disease cause rarefaction of pial collaterals and increased severity of ischemic stroke. / 05.2019 / PubMed / Full text
• Loss of complement regulatory proteins on uninfected erythrocytes in vivax and falciparum malaria anemia. / 15.11.2018 / PubMed / Full text
• Recent studies on cellular and molecular mechanisms in Alzheimer's disease: focus on epigenetic factors and histone deacetylase. / 28.03.2018 / PubMed / Full text
• Genetic Biomarkers on Age-Related Cognitive Decline. / 2017 / PubMed / Full text
• Associations between management practices and major reproductive parameters of Holstein-Friesian replacement heifers. / 01.2018 / PubMed / Full text

CXCL10

• Age-related decline of interferon-gamma responses in macrophage impairs satellite cell proliferation and regeneration. / 10.2020 / PubMed / Full text
• Neuroprotective effects of targeting BET proteins for degradation with dBET1 in aged mice subjected to ischemic stroke. / 07.2019 / PubMed / Full text
• Towards frailty biomarkers: Candidates from genes and pathways regulated in aging and age-related diseases. / 11.2018 / PubMed / Full text
• Age-related pro-inflammatory and pro-angiogenic changes in human aqueous humor. / 2018 / PubMed / Full text
• Aged Chinese-origin rhesus macaques infected with SIV develop marked viremia in absence of clinical disease, inflammation or cognitive impairment. / 01.02.2018 / PubMed / Full text
• Immune senescence and biomarkers profile of Bambuí aged population-based cohort. / 03.2018 / PubMed / Full text
• Dysregulation of C-X-C motif ligand 10 during aging and association with cognitive performance. / 03.2018 / PubMed / Full text

DBI

• Quantifying cumulative anticholinergic and sedative drug load among US Medicare Beneficiaries. / 01.10.2020 / PubMed / Full text
• Drug Burden Index and Cognitive and Physical Function in Aged Care Residents: A Longitudinal Study. / 08.2020 / PubMed / Full text
• Using the Drug Burden Index to identify older adults at highest risk for medication-related falls. / 12.06.2020 / PubMed / Full text
• Impact of STEADI-Rx: A Community Pharmacy-Based Fall Prevention Intervention. / 08.2020 / PubMed / Full text
• Association of Drug Burden Index with grip strength, timed up and go and Barthel index activities of daily living in older adults with intellectual disabilities: an observational cross-sectional study. / 24.06.2019 / PubMed / Full text
• Impact of drug burden index on adverse health outcomes in Irish community-dwelling older people: a cohort study. / 29.04.2019 / PubMed / Full text
• Dietary Balance Index-07 and the Risk of Anemia in Middle Aged and Elderly People in Southwest China: A Cross Sectional Study. / 31.01.2018 / PubMed / Full text

FAS

• Five-year change in maximum tongue pressure and physical function in community-dwelling elderly adults. / 09.2020 / PubMed / Full text
• Inhibition of USP7 activity selectively eliminates senescent cells in part via restoration of p53 activity. / 03.2020 / PubMed / Full text
• Application of GFR estimation equations in elderly patients with measured GFR below 60 mL/min/1.73 m . / 03.2020 / PubMed / Full text
• Dietary methionine increased the lipid accumulation in juvenile tiger puffer Takifugu rubripes. / 04.2019 / PubMed / Full text
• Genetic and Environmental Influences on Language Ability in Older Adults: Findings from the Older Australian Twins Study. / 05.2018 / PubMed / Full text
• Effects of aging on fat deposition and meat quality in Sheldrake duck. / 01.06.2018 / PubMed / Full text
• Impact of sociodemographic variables on executive functions. / 01-03.2017 / PubMed / Full text

MFI

• The Influence of the Accelerated Aging Conditions on the Properties of Polyolefin Geogrids Used for Landfill Slope Reinforcement. / 20.08.2020 / PubMed / Full text
• Changes in Physical Meat Traits, Protein Solubility, and the Microstructure of Different Beef Muscles during Post-Mortem Aging. / 19.06.2020 / PubMed / Full text
• Effect of a low-voltage electrical stimulation on yak meat tenderness during postmortem aging. / 01-12.2020 / PubMed / Full text
• Comparative effects of dry-aging and wet-aging on physicochemical properties and digestibility of Hanwoo beef. / 03.2020 / PubMed / Full text
• Sexual dimorphism in rat thymic involution: a correlation with thymic oxidative status and inflammation. / 08.2019 / PubMed / Full text
• Circulating soluble RAGE and cell surface RAGE on peripheral blood mononuclear cells in healthy children. / 27.06.2018 / PubMed / Full text
• The frail fail: Increased mortality and post-operative complications in orthopaedic trauma patients. / 11.2017 / PubMed / Full text

MMP13

• Aging aggravates intervertebral disc degeneration by regulating transcription factors toward chondrogenesis. / 02.2020 / PubMed / Full text
• EGR1 promotes the cartilage degeneration and hypertrophy by activating the Krüppel-like factor 5 and β-catenin signaling. / 01.09.2019 / PubMed / Full text
• Chondrocyte-Specific RUNX2 Overexpression Accelerates Post-traumatic Osteoarthritis Progression in Adult Mice. / 09.2019 / PubMed / Full text
• TGF-β type 2 receptor-mediated modulation of the IL-36 family can be therapeutically targeted in osteoarthritis. / 08.05.2019 / PubMed / Full text
• Systemic clearance of p16 -positive senescent cells mitigates age-associated intervertebral disc degeneration. / 06.2019 / PubMed / Full text
• Design, cyclization, and optimization of MMP13-TIMP1 interaction-derived self-inhibitory peptides against chondrocyte senescence in osteoarthritis. / 01.2019 / PubMed / Full text
• Overexpression of microRNA-1470 promotes proliferation and migration, and inhibits senescence of esophageal squamous carcinoma cells. / 12.2017 / PubMed / Full text

MPO

• Impaired sleep quality is associated with concurrent elevations in inflammatory markers: are post-menopausal women at greater risk? / 08.07.2019 / PubMed / Full text
• Local and systemic effects of aging on acute pancreatitis. / 07.2019 / PubMed / Full text
• Inflammatory signatures in older persons with physical frailty and sarcopenia: The frailty "cytokinome" at its core. / 15.07.2019 / PubMed / Full text
• Astaxanthin-Rich [i]Haematococcus pluvialis[/i] Algal Hepatic Modulation in D-Galactose-Induced Aging in Rats: Role of Nrf2. / 08.2018 / PubMed / Full text
• Effect of β-D-Mannuronic Acid (M2000) on Oxidative Stress Enzymes' Gene Using Healthy Donor Peripheral Blood Mononuclear Cells for Evaluating the Anti-Aging Property. / 2019 / PubMed / Full text
• Chlorinative stress in age-related diseases: a literature review. / 2017 / PubMed / Full text
• Hippocampal-dependent memory deficit induced by perinatal exposure to polutted eels in middle-aged offspring mice: Sex differential effects. / 05.10.2017 / PubMed / Full text

NOX4

• Sestrin2 Attenuates Cellular Senescence by Inhibiting NADPH Oxidase 4 Expression. / 24.11.2020 / PubMed / Full text
• NADPH Oxidases and Aging Models of Lung Fibrosis. / 2019 / PubMed / Full text
• Age-related distribution and potential role of SNCB in topographically different retinal areas of the common marmoset Callithrix jacchus, including the macula. / 08.2019 / PubMed / Full text
• Expression of lipogenic markers is decreased in subcutaneous adipose tissue and adipocytes of older women and is negatively linked to GDF15 expression. / 08.2019 / PubMed / Full text
• Redox Imbalance in Idiopathic Pulmonary Fibrosis: A Role for Oxidant Cross-Talk Between NADPH Oxidase Enzymes and Mitochondria. / 10.11.2019 / PubMed / Full text
• NADPH oxidase 4 mediates ROS production in radiation-induced senescent cells and promotes migration of inflammatory cells. / 01.2018 / PubMed / Full text
• Alternative Splicing of NOX4 in the Failing Human Heart. / 2017 / PubMed / Full text

NPY

• Neuropeptide Y Enhances Progerin Clearance and Ameliorates the Senescent Phenotype of Human Hutchinson-Gilford Progeria Syndrome Cells. / 22.05.2020 / PubMed / Full text
• Effects of rikkunshito supplementation on resistance to oxidative stress and lifespan in mice. / 03.2020 / PubMed / Full text
• Autophagy within the mushroom body protects from synapse aging in a non-cell autonomous manner. / 21.03.2019 / PubMed / Full text
• β-Alanine supplementation reduces anxiety and increases neurotrophin expression in both young and older rats. / 02.2019 / PubMed / Full text
• Age-related central regulation of orexin and NPY in the short-lived African killifish Nothobranchius furzeri. / 15.05.2019 / PubMed / Full text
• Chronic treatment with tributyltin induces sexually dimorphic alterations in the hypothalamic POMC system of adult mice. / 12.2018 / PubMed / Full text
• Expression of CGRP neurotransmitter and vascular genesis marker mRNA is age-dependent in superior cervical ganglia of senescence-accelerated prone mice. / 18.01.2018 / PubMed / Full text

OPA1

• [i]Sirt3[/i] Deficiency Shortens Life Span and Impairs Cardiac Mitochondrial Function Rescued by [i]Opa1[/i] Gene Transfer. / 12.2019 / PubMed / Full text
• Novel role of the SIRT4-OPA1 axis in mitochondrial quality control. / 23.12.2017 / PubMed / Full text
• Inhibition of the Fission Machinery Mitigates OPA1 Impairment in Adult Skeletal Muscles. / 15.06.2019 / PubMed / Full text
• Increased Degradation Rates in the Components of the Mitochondrial Oxidative Phosphorylation Chain in the Cerebellum of Old Mice. / 2018 / PubMed / Full text
• SIRT4 interacts with OPA1 and regulates mitochondrial quality control and mitophagy. / 29.10.2017 / PubMed / Full text
• Optic atrophy 1 mediates coenzyme Q-responsive regulation of respiratory complex IV activity in brain mitochondria. / 11.2017 / PubMed / Full text
• Dietary supplementation with acetyl-l-carnitine counteracts age-related alterations of mitochondrial biogenesis, dynamics and antioxidant defenses in brain of old rats. / 11.2017 / PubMed / Full text

RET

• Effects of resistance exercise training on redox homeostasis in older adults. A systematic review and meta-analysis. / 09.2020 / PubMed / Full text
• Effects of an 8-week resistance training intervention on plantar flexor muscle quality and functional capacity in older women: A randomised controlled trial. / 09.2020 / PubMed / Full text
• Resistance exercise training promotes fiber type-specific myonuclear adaptations in older adults. / 01.04.2020 / PubMed / Full text
• Low skeletal muscle capillarization limits muscle adaptation to resistance exercise training in older adults. / 11.2019 / PubMed / Full text
• Resistance Exercise Training as a Primary Countermeasure to Age-Related Chronic Disease. / 2019 / PubMed / Full text
• Physical, Chemical, Microstructural and Rheological Properties of Reactive Terpolymer-Modified Bitumen. / 20.03.2019 / PubMed / Full text
• Citrulline counteracts overweight- and aging-related effects on adiponectin and leptin gene expression in rat white adipose tissue. / 2015 / PubMed / Full text

SPARC

• SPARC Metrics Provide Mobility Smoothness Assessment in Oldest-Old With and Without a History of Falls: A Case Control Study. / 2020 / PubMed / Full text
• Reduced fibrillar collagen accumulation in skeletal muscle of secreted protein acidic and rich in cysteine (SPARC)-null mice. / 29.11.2019 / PubMed / Full text
• Specific factors in blood from young but not old mice directly promote synapse formation and NMDA-receptor recruitment. / 18.06.2019 / PubMed / Full text
• Lifelong aerobic exercise protects against inflammaging and cancer. / 2019 / PubMed / Full text
• SPARC is required for the maintenance of glucose homeostasis and insulin secretion in mice. / 31.01.2019 / PubMed / Full text
• Aging may negatively impact movement smoothness during stair negotiation. / 08.2018 / PubMed / Full text
• The impact of SPARC on age-related cardiac dysfunction and fibrosis in Drosophila. / 08.2018 / PubMed / Full text

TOMM40

• A candidate gene study of risk for dementia in older, postmenopausal women: Results from the Women's Health Initiative Memory Study. / 05.2019 / PubMed / Full text
• Independent associations of TOMM40 and APOE variants with body mass index. / 02.2019 / PubMed / Full text
• Genetics of Human Longevity From Incomplete Data: New Findings From the Long Life Family Study. / 08.10.2018 / PubMed / Full text
• Genetic Risk for Age-Related Cognitive Impairment Does Not Predict Cognitive Performance in Middle Age. / 2018 / PubMed / Full text
• Apolipoprotein E region molecular signatures of Alzheimer's disease. / 08.2018 / PubMed / Full text
• Genetic Variation in FOXO3 is Associated with Self-Rated Health in a Population-Based Sample of Older Individuals. / 08.10.2018 / PubMed / Full text
• Genetic variants specific to aging-related verbal memory: Insights from GWASs in a population-based cohort. / 2017 / PubMed / Full text

TST

• H S Donors Reverse Age-Related Gastric Malfunction Impaired Due to Fructose-Induced Injury [i]via[/i] CBS, CSE, and TST Expression. / 2020 / PubMed / Full text
• Adaptations in mechanical muscle function, muscle morphology, and aerobic power to high-intensity endurance training combined with either traditional or power strength training in older adults: a randomized clinical trial. / 05.2020 / PubMed / Full text
• Digital phenotyping by consumer wearables identifies sleep-associated markers of cardiovascular disease risk and biological aging. / 2019 / PubMed / Full text
• Objective Sleep Duration in Older Adults: Results From The Irish Longitudinal Study on Ageing. / 01.2020 / PubMed / Full text
• Subjective Cognitive Decline and Nighttime Sleep Alterations, a Longitudinal Analysis. / 2019 / PubMed / Full text
• Validity Evaluation of the Fitbit Charge2 and the Garmin vivosmart HR+ in Free-Living Environments in an Older Adult Cohort. / 19.06.2019 / PubMed / Full text
• Paradoxical effect of testosterone supplementation therapy on cardiac ischemia/reperfusion injury in aged rats. / 07.2019 / PubMed / Full text

UCP2

• Potential Role of Leptin in Cardiac Steatosis Induced by Highly Saturated Fat Intake during Adolescence. / 10.2019 / PubMed / Full text
• Effect of Initial Aging and High-Fat/High-Fructose Diet on Mitochondrial Bioenergetics and Oxidative Status in Rat Brain. / 11.2019 / PubMed / Full text
• Decreased uncoupling protein 2 expression in aging retinal pigment epithelial cells. / 2019 / PubMed / Full text
• The Role of Genetic Profile in Functional Performance Adaptations to Exercise Training or Physical Activity: A Systematic Review of the Literature. / 01.08.2019 / PubMed / Full text
• G-1 exhibit antidepressant effect, increase of hippocampal ERs expression and improve hippocampal redox status in aged female rats. / 01.02.2019 / PubMed / Full text
• Rapamycin increases oxidative metabolism and enhances metabolic flexibility in human cardiac fibroblasts. / 21.06.2018 / PubMed / Full text
• Sestrin2 prevents age-related intolerance to post myocardial infarction via AMPK/PGC-1α pathway. / 02.2018 / PubMed / Full text

VDR

• 25-Hydroxyvitamin D positively regulates periodontal inflammaging via SOCS3/STAT signaling in diabetic mice. / 04.2020 / PubMed / Full text
• 1,25-Dihydroxyvitamin D protects against age-related osteoporosis by a novel VDR-Ezh2-p16 signal axis. / 02.2020 / PubMed / Full text
• Active vitamin D impedes the progression of non-alcoholic fatty liver disease by inhibiting cell senescence in a rat model. / 09.2020 / PubMed / Full text
• Age-dependent expression of the vitamin D receptor and the protective effect of vitamin D receptor activation on H O -induced apoptosis in rat intervertebral disc cells. / 06.2019 / PubMed / Full text
• Vitamin D Receptor in Muscle Atrophy of Elderly Patients: A Key Element of Osteoporosis-Sarcopenia Connection. / 12.2018 / PubMed / Full text
• Reduced vitamin D receptor (VDR) expression and plasma vitamin D levels are associated with aging-related prostate lesions. / 05.2018 / PubMed / Full text
• VDR Activation Reduces Proteinuria and High-Glucose-Induced Injury of Kidneys and Podocytes by Regulating Wnt Signaling Pathway. / 2017 / PubMed / Full text

ADAM10

• NKG2D Ligand Shedding in Response to Stress: Role of ADAM10. / 2020 / PubMed / Full text
• Chronic Mild Stress Modified Epigenetic Mechanisms Leading to Accelerated Senescence and Impaired Cognitive Performance in Mice. / 10.02.2020 / PubMed / Full text
• Removal of p75 Neurotrophin Receptor Expression from Cholinergic Basal Forebrain Neurons Reduces Amyloid-β Plaque Deposition and Cognitive Impairment in Aged APP/PS1 Mice. / 07.2019 / PubMed / Full text
• 11β-HSD1 Inhibition by RL-118 Promotes Autophagy and Correlates with Reduced Oxidative Stress and Inflammation, Enhancing Cognitive Performance in SAMP8 Mouse Model. / 12.2018 / PubMed / Full text
• Effects of senescence and angiotensin II on expression and processing of amyloid precursor protein in human cerebral microvascular endothelial cells. / 15.01.2018 / PubMed / Full text
• microRNA 221 Targets ADAM10 mRNA and is Downregulated in Alzheimer's Disease. / 2018 / PubMed / Full text

AIP

• [Aryl hydrocarbon receptor interacting protein (AIP) in human dermis during aging.] / 2020 / PubMed
• Sex-Specific Association between Serum Vitamin D Status and Lipid Profiles: A Cross-Sectional Study of a Middle-Aged and Elderly Chinese Population. / 2020 / PubMed / Full text
• The oblique effect: The relationship between profiles of visuospatial preference, cognition, and brain connectomics in older adults. / 12.2019 / PubMed / Full text
• A logic of choice: Problematizing the documentary reality of Canadian aging in place policies. / 03.2019 / PubMed / Full text
• Enhanced basal late sodium current appears to underlie the age-related prolongation of action potential duration in guinea pig ventricular myocytes. / 14.12.2017 / PubMed / Full text
• Building IoT Services for Aging in Place Using Standard-Based IoT Platforms and Heterogeneous IoT Products. / 11.10.2017 / PubMed / Full text

AKT1

• MicroRNA-495 enhances chondrocyte apoptosis, senescence and promotes the progression of osteoarthritis by targeting AKT1. / 2019 / PubMed / Full text
• Therapeutic and preventive effects of exercise on cardiometabolic parameters in aging and obese rats. / 02.2019 / PubMed / Full text
• The biological age linked to oxidative stress modifies breast cancer aggressiveness. / 20.05.2018 / PubMed / Full text
• Menopause and adipose tissue: miR-19a-3p is sensitive to hormonal replacement. / 05.01.2018 / PubMed / Full text
• SIRT6 histone deacetylase functions as a potential oncogene in human melanoma. / 09.2017 / PubMed / Full text
• G protein-coupled receptor kinase 4-induced cellular senescence and its senescence-associated gene expression profiling. / 15.11.2017 / PubMed / Full text

ALDH2

• Aldehyde Dehydrogenase 2 (ALDH2) and Aging: Is There a Sensible Link? / 2019 / PubMed / Full text
• Appropriate dose of ethanol exerts anti-senescence and anti-atherosclerosis protective effects by activating ALDH2. / 30.04.2019 / PubMed / Full text
• Impaired enzymatic reactive aldehyde-detoxifying capacity and glutathione peroxidase activity in the aged human arterial tissue. / 02.2019 / PubMed / Full text
• Telomere shortening in alcohol dependence: Roles of alcohol and acetaldehyde. / 02.2019 / PubMed / Full text
• Aldehyde dehydrogenase 2 deficiency promotes atherosclerotic plaque instability through accelerating mitochondrial ROS-mediated vascular smooth muscle cell senescence. / 01.07.2019 / PubMed / Full text
• ALDH2 mediates the dose-response protection of chronic ethanol against endothelial senescence through SIRT1/p53 pathway. / 12.10.2018 / PubMed / Full text

ARNT

• Loss of ARNT in skeletal muscle limits muscle regeneration in aging. / 12.2020 / PubMed / Full text
• [Arylhydrocarbon receptor nuclear translocator (ARNT) in human skin during aging.] / 2020 / PubMed
• The E3 ubiquitin ligase STUB1 attenuates cell senescence by promoting the ubiquitination and degradation of the core circadian regulator BMAL1. / 03.04.2020 / PubMed / Full text
• Deficiency of Bmal1 disrupts the diurnal rhythm of haemostasis. / 04.2019 / PubMed / Full text
• Insulin-like growth factor-1 acts as a zeitgeber on hypothalamic circadian clock gene expression via glycogen synthase kinase-3β signaling. / 02.11.2018 / PubMed / Full text
• Aging and chromatoid body assembly: Are these two physiological events linked? / 07.2018 / PubMed / Full text

BRCA2

• Analysis of somatic mutations identifies signs of selection during in vitro aging of primary dermal fibroblasts. / 12.2019 / PubMed / Full text
• Klotho gene polymorphisms are associated with healthy aging and longevity: Evidence from a meta-analysis. / 03.2019 / PubMed / Full text
• The replicative senescent mesenchymal stem / stromal cells defect in DNA damage response and anti-oxidative capacity. / 2018 / PubMed / Full text
• Faulty BRCA1, BRCA2 genes: how poor is the prognosis? / 10.2017 / PubMed / Full text
• Ovarian Aging in Women With BRCA Germline Mutations. / 01.10.2017 / PubMed / Full text
• The expected benefit of preventive mastectomy on breast cancer incidence and mortality in BRCA mutation carriers, by age at mastectomy. / 01.2018 / PubMed / Full text

C9

• C9orf72 in myeloid cells suppresses STING-induced inflammation. / 09.2020 / PubMed / Full text
• Glycine-alanine dipeptide repeats spread rapidly in a repeat length- and age-dependent manner in the fly brain. / 16.12.2019 / PubMed / Full text
• Human iPSC-derived astrocytes from ALS patients with mutated C9ORF72 show increased oxidative stress and neurotoxicity. / 12.2019 / PubMed / Full text
• Age and Sex-Associated Changes of Complement Activity and Complement Levels in a Healthy Caucasian Population. / 2018 / PubMed / Full text
• TMT-Based Quantitative Proteomic Analysis Reveals Proteomic Changes Involved in Longevity. / 07.2019 / PubMed / Full text
• C9orf72 Dipeptide Repeats Cause Selective Neurodegeneration and Cell-Autonomous Excitotoxicity in [i]Drosophila[/i] Glutamatergic Neurons. / 29.08.2018 / PubMed / Full text

CA4

• Dissociable age and memory relationships with hippocampal subfield volumes in vivo:Data from the Irish Longitudinal Study on Ageing (TILDA). / 29.07.2019 / PubMed / Full text
• Aerobic exercise increases hippocampal subfield volumes in younger adults and prevents volume decline in the elderly. / 10.2020 / PubMed / Full text
• The Volume of Hippocampal Subfields in Relation to Decline of Memory Recall Across the Adult Lifespan. / 2018 / PubMed / Full text
• Alzheimer's Disease Biomarkers Have Distinct Associations with Specific Hippocampal Subfield Volumes. / 2018 / PubMed / Full text
• Age-related changes in cortical and subcortical structures of healthy adult brains: A surface-based morphometry study. / 01.2019 / PubMed / Full text
• Hippocampal sclerosis, hippocampal neuron loss patterns and TDP-43 in the aged population. / 07.2018 / PubMed / Full text

CBS

• Permanent cystathionine-β-Synthase gene knockdown promotes inflammation and oxidative stress in immortalized human adipose-derived mesenchymal stem cells, enhancing their adipogenic capacity. / 02.08.2020 / PubMed / Full text
• Cardiovascular phenotype of mice lacking 3-mercaptopyruvate sulfurtransferase. / 06.2020 / PubMed / Full text
• Methionine restriction leads to hyperhomocysteinemia and alters hepatic H S production capacity in Fischer-344 rats. / 12.2018 / PubMed / Full text
• Human Cord Blood Serum-Derived APP α-Secretase Cleavage Activity is Mediated by C1 Complement. / 04.2018 / PubMed / Full text
• Dietary and Endocrine Regulation of Endogenous Hydrogen Sulfide Production: Implications for Longevity. / 01.06.2018 / PubMed / Full text
• Nitration-mediated deficiency of cystathionine β-synthase activity accelerates the progression of hyperhomocysteinemia. / 12.2017 / PubMed / Full text

CD47

• Aging-associated changes in CD47 arrangement and interaction with thrombospondin-1 on red blood cells visualized by super-resolution imaging. / 10.2020 / PubMed / Full text
• CD47 Promotes Age-Associated Deterioration in Angiogenesis, Blood Flow and Glucose Homeostasis. / 15.07.2020 / PubMed / Full text
• Unique Spatial Immune Profiling in Pancreatic Ductal Adenocarcinoma with Enrichment of Exhausted and Senescent T Cells and Diffused CD47-SIRPα Expression. / 07.07.2020 / PubMed / Full text
• Diabetes Impairs Angiogenesis and Induces Endothelial Cell Senescence by Up-Regulating Thrombospondin-CD47-Dependent Signaling. / 04.02.2019 / PubMed / Full text
• Loss of complement regulatory proteins on uninfected erythrocytes in vivax and falciparum malaria anemia. / 15.11.2018 / PubMed / Full text
• The matricellular protein TSP1 promotes human and mouse endothelial cell senescence through CD47 and Nox1. / 17.10.2017 / PubMed / Full text

CD5

• Comparative proteomic analysis identifies biomarkers for renal aging. / 06.11.2020 / PubMed / Full text
• Crucial Role of Increased Arid3a at the Pre-B and Immature B Cell Stages for B1a Cell Generation. / 2019 / PubMed / Full text
• Correlation of cell-surface CD8 levels with function, phenotype and transcriptome of naive CD8 T cells. / 04.2019 / PubMed / Full text
• Early Generated B-1-Derived B Cells Have the Capacity To Progress To Become Mantle Cell Lymphoma-like Neoplasia in Aged Mice. / 15.07.2018 / PubMed / Full text
• Age-related changes in mRNA expression of selected surface receptors in lymphocytes of dairy calves. / 03.2018 / PubMed / Full text
• Altered marginal zone and innate-like B cells in aged senescence-accelerated SAMP8 mice with defective IgG1 responses. / 17.08.2017 / PubMed / Full text

CPM

• Test-Retest Instability of Temporal Summation and Conditioned Pain Modulation Measures in Older Adults. / 21.10.2020 / PubMed / Full text
• Age does not affect sex effect of conditioned pain modulation of pressure and thermal pain across 2 conditioning stimuli. / 01-02.2020 / PubMed / Full text
• The Decline of Endogenous Pain Modulation With Aging: A Meta-Analysis of Temporal Summation and Conditioned Pain Modulation. / 05-06.2020 / PubMed / Full text
• A keratinocyte and integrated fibroblast culture model for studying particulate matter-induced skin lesions and therapeutic intervention of fucosterol. / 15.09.2019 / PubMed / Full text
• Daily physical activity patterns among aging workers: the Finnish Retirement and Aging Study (FIREA). / 01.2019 / PubMed / Full text
• Resting-state functional connectivity predicts neuroticism and extraversion in novel individuals. / 01.02.2018 / PubMed / Full text

CX3CL1

• Two forms of CX3CL1 display differential activity and rescue cognitive deficits in CX3CL1 knockout mice. / 14.05.2020 / PubMed / Full text
• Expression of pro- and anti-inflammatory cytokines and chemokines during the ovulatory cycle and effects of aging on their expression in the uterine mucosa of laying hens. / 11.2018 / PubMed / Full text
• Towards frailty biomarkers: Candidates from genes and pathways regulated in aging and age-related diseases. / 11.2018 / PubMed / Full text
• Surgical Trauma Exacerbates Cognitive Deficits and Neuroinflammation in Aged Rats: The Role of CX3CL1-CX3CR1 Signaling. / 01.08.2018 / PubMed / Full text
• Repopulating retinal microglia restore endogenous organization and function under CX3CL1-CX3CR1 regulation. / 03.2018 / PubMed / Full text
• Microglia and Aging: The Role of the TREM2-DAP12 and CX3CL1-CX3CR1 Axes. / 22.01.2018 / PubMed / Full text

CXCL2

• Inflammatory and Senescent Phenotype of Pancreatic Stellate Cells Induced by Sqstm1 Downregulation Facilitates Pancreatic Cancer Progression. / 2019 / PubMed / Full text
• Long-term every-other-day administration of DMAMCL has little effect on aging and age-associated physiological decline in mice. / 02.05.2019 / PubMed / Full text
• A Neutrophil Timer Coordinates Immune Defense and Vascular Protection. / 19.02.2019 / PubMed / Full text
• Excessive neutrophil levels in the lung underlie the age-associated increase in influenza mortality. / 03.2019 / PubMed / Full text
• Time-Dependent Changes in Local and Serum Levels of Inflammatory Cytokines as Markers for Incised Wound Aging of Skeletal Muscles. / 05.2018 / PubMed / Full text
• Tumor microenvironment in functional adrenocortical adenomas: immune cell infiltration in cortisol-producing adrenocortical adenoma. / 07.2018 / PubMed / Full text

CXCR2

• CXCL5-CXCR2 signaling is a senescence-associated secretory phenotype in preimplantation embryos. / 10.2020 / PubMed / Full text
• Senescence in Wound Repair: Emerging Strategies to Target Chronic Healing Wounds. / 2020 / PubMed / Full text
• Cellular Senescence in Diabetic Wounds: When Too Many Retirees Stress the System. / 05.2019 / PubMed / Full text
• Elevated Local Senescence in Diabetic Wound Healing Is Linked to Pathological Repair via CXCR2. / 05.2019 / PubMed / Full text
• A Neutrophil Timer Coordinates Immune Defense and Vascular Protection. / 19.02.2019 / PubMed / Full text
• Chronic Resveratrol Treatment Reduces the Pro-angiogenic Effect of Human Fibroblast "Senescent-Associated Secretory Phenotype" on Endothelial Colony-Forming Cells: The Role of IL8. / 23.04.2019 / PubMed / Full text

DPP4

• Age-Dependent Assessment of Genes Involved in Cellular Senescence, Telomere, and Mitochondrial Pathways in Human Lung Tissue of Smokers, COPD, and IPF: Associations With SARS-CoV-2 COVID-19 ACE2-TMPRSS2-Furin-DPP4 Axis. / 2020 / PubMed / Full text
• Dipeptidyl peptidase-4 inhibition improves endothelial senescence by activating AMPK/SIRT1/Nrf2 signaling pathway. / 07.2020 / PubMed / Full text
• Molecular crosstalk between Y5 receptor and neuropeptide Y drives liver cancer. / 01.05.2020 / PubMed / Full text
• Dose rectification of an imbalance between DPP4 and GLP-1 ameliorates chronic stress-related vascular aging and atherosclerosis? / 05.2018 / PubMed / Full text
• Chronic Psychological Stress Accelerates Vascular Senescence and Impairs Ischemia-Induced Neovascularization: The Role of Dipeptidyl Peptidase-4/Glucagon-Like Peptide-1-Adiponectin Axis. / 28.09.2017 / PubMed / Full text
• Identification of senescent cell surface targetable protein DPP4. / 01.08.2017 / PubMed / Full text

DRD2

• Cortical thickness mediates the relationship between DRD2 C957T polymorphism and executive function across the adult lifespan. / 11.11.2020 / PubMed / Full text
• The relationship of age and DRD2 polymorphisms to frontostriatal brain activity and working memory performance. / 12.2019 / PubMed / Full text
• Dopamine-Related Genotypes and Physical Activity Change During an Intervention: The Lifestyle Interventions and Independence for Elders Study. / 07.2018 / PubMed / Full text
• Influence of the DRD2/ANKK1 Taq1A polymorphism on caudate volume in older adults without dementia. / 07.2018 / PubMed / Full text
• FTO affects food cravings and interacts with age to influence age-related decline in food cravings. / 01.08.2018 / PubMed / Full text
• The DRD2 Taq1A A1 Allele May Magnify the Risk of Alzheimer's in Aging African-Americans. / 07.2018 / PubMed / Full text

EDA

• Interplay between aging, lung inflammation/remodeling, and fibronectin EDA in lung cancer progression. / 01.12.2020 / PubMed / Full text
• Arousal Detection in Elderly People from Electrodermal Activity Using Musical Stimuli. / 25.08.2020 / PubMed / Full text
• The structure of agricultural microplastics (PT, PU and UF) and their sorption capacities for PAHs and PHE derivates under various salinity and oxidation treatments. / 02.2020 / PubMed / Full text
• Effect of storage on quality parameters and phenolic content of Italian extra-virgin olive oils. / 01.2020 / PubMed / Full text
• Fibronectin Containing Extra Domain A Induces Plaque Destabilization in the Innominate Artery of Aged Apolipoprotein E-Deficient Mice. / 03.2018 / PubMed / Full text
• An Extract from the Plant [i]Deschampsia antarctica[/i] Protects Fibroblasts from Senescence Induced by Hydrogen Peroxide. / 2017 / PubMed / Full text

FAP

• Rapamycin Extends Life Span in Apc Colon Cancer FAP Model. / 15.09.2020 / PubMed / Full text
• Exercise enhances skeletal muscle regeneration by promoting senescence in fibro-adipogenic progenitors. / 14.02.2020 / PubMed / Full text
• Control of Muscle Fibro-Adipogenic Progenitors by Myogenic Lineage is Altered in Aging and Duchenne Muscular Dystrophy. / 2019 / PubMed / Full text
• Higher serum levels of fibroblast growth factor 21 in old patients with cachexia. / 07-08.2019 / PubMed / Full text
• Aging Disrupts Muscle Stem Cell Function by Impairing Matricellular WISP1 Secretion from Fibro-Adipogenic Progenitors. / 07.03.2019 / PubMed / Full text
• Odd skipped-related 1 identifies a population of embryonic fibro-adipogenic progenitors regulating myogenesis during limb development. / 31.10.2017 / PubMed / Full text

FH

• Genetic Factors of Alzheimer's Disease Modulate How Diet is Associated with Long-Term Cognitive Trajectories: A UK Biobank Study. / 2020 / PubMed / Full text
• Volumetric alterations in the hippocampal subfields of subjects at increased risk of dementia. / 07.2020 / PubMed / Full text
• Macroscopic hematuria as a risk factor for hypertension in ageing people with hemophilia and a family history of hypertension. / 02.2020 / PubMed / Full text
• LDL Receptor Deficiency Does not Alter Brain Amyloid-β Levels but Causes an Exacerbation of Apoptosis. / 2020 / PubMed / Full text
• Sex differences in cholesterol levels from birth to 19 years of age may lead to increased cholesterol burden in females with FH. / 05-06.2018 / PubMed / Full text
• Association between lipoprotein (a) and proprotein convertase substilisin/kexin type 9 in patients with heterozygous familial hypercholesterolemia: A case-control study. / 02.2018 / PubMed / Full text

FNDC5

• Irisin Correlates Positively With BMD in a Cohort of Older Adult Patients and Downregulates the Senescent Marker p21 in Osteoblasts. / 14.10.2020 / PubMed / Full text
• [Investigation of signal molecules in saliva: prospects of application for diagnostics of myocardial infarction and the aging rate of different age people.] / 2019 / PubMed
• Mechanistic complexities of bone loss in Alzheimer's disease: a review. / 01.2020 / PubMed / Full text
• Towards frailty biomarkers: Candidates from genes and pathways regulated in aging and age-related diseases. / 11.2018 / PubMed / Full text
• Exercise Training Protects Against Aging-Induced Cognitive Dysfunction via Activation of the Hippocampal PGC-1α/FNDC5/BDNF Pathway. / 09.2018 / PubMed / Full text
• Epistasis, physical capacity-related genes and exceptional longevity: FNDC5 gene interactions with candidate genes FOXOA3 and APOE. / 14.11.2017 / PubMed / Full text

FOXO4

• FOXO4-DRI alleviates age-related testosterone secretion insufficiency by targeting senescent Leydig cells in aged mice. / 20.01.2020 / PubMed / Full text
• Introduction to FOXO Biology. / 2019 / PubMed / Full text
• Regulation of cellular senescence via the FOXO4-p53 axis. / 06.2018 / PubMed / Full text
• Cellular senescence in the aging and diseased kidney. / 03.2018 / PubMed / Full text
• [Molecular regulative mechanisms of aging and interventional effects of Chinese herbal medicine]. / 08.2017 / PubMed / Full text
• FOXO Transcriptional Factors and Long-Term Living. / 2017 / PubMed / Full text

FST

• Comorbid sensorimotor and emotional profiles in the forced swim test immobility and predictive value of a single assay in very old female mice. / 06.2019 / PubMed / Full text
• Structure-function multi-scale connectomics reveals a major role of the fronto-striato-thalamic circuit in brain aging. / 12.2018 / PubMed / Full text
• Exercise related anxiety-like behaviours are mediated by TNF receptor signaling, but not depression-like behaviours. / 15.09.2018 / PubMed / Full text
• Preliminary Data on Some Behavioral Changes Induced by Short-Term Intraperitoneal Oxytocin Administration in Aged Rats. / 03.2018 / PubMed / Full text
• Proteomic profiling of follicle fluids after superstimulation in one-month-old lambs. / 02.2018 / PubMed / Full text
• Desipramine rescues age-related phenotypes in depression-like rats induced by chronic mild stress. / 01.11.2017 / PubMed / Full text

FTO

• Decreased expression of m A demethylase FTO in ovarian aging. / 22.11.2020 / PubMed / Full text
• ALKB-8, a 2-Oxoglutarate-Dependent Dioxygenase and S-Adenosine Methionine-Dependent Methyltransferase Modulates Metabolic Events Linked to Lysosome-Related Organelles and Aging in C. elegans. / 2018 / PubMed
• The GDF11-FTO-PPARγ axis controls the shift of osteoporotic MSC fate to adipocyte and inhibits bone formation during osteoporosis. / 12.2018 / PubMed / Full text
• Genome-wide meta-analysis of macronutrient intake of 91,114 European ancestry participants from the cohorts for heart and aging research in genomic epidemiology consortium. / 12.2019 / PubMed / Full text
• FTO is involved in Alzheimer's disease by targeting TSC1-mTOR-Tau signaling. / 25.03.2018 / PubMed / Full text
• FTO affects food cravings and interacts with age to influence age-related decline in food cravings. / 01.08.2018 / PubMed / Full text

GATA4

• Epigenetics and Vascular Senescence-Potential New Therapeutic Targets? / 2020 / PubMed / Full text
• Prolonged treatment with Y-27632 promotes the senescence of primary human dermal fibroblasts by increasing the expression of IGFBP-5 and transforming them into a CAF-like phenotype. / 25.08.2020 / PubMed / Full text
• The zinc finger protein GATA4 induces mesenchymal-to-epithelial transition and cellular senescence through the nuclear factor-κB pathway in hepatocellular carcinoma. / 12.2019 / PubMed / Full text
• Isolation, Characterization, and Differentiation of Cardiac Stem Cells from the Adult Mouse Heart. / 07.01.2019 / PubMed / Full text
• GATA Regulation and Function During the Ovarian Life Cycle. / 2018 / PubMed / Full text
• Genetic interrogation of replicative senescence uncovers a dual role for USP28 in coordinating the p53 and GATA4 branches of the senescence program. / 01.10.2017 / PubMed / Full text

GDNF

• GFR-α1 Expression in Substantia Nigra Increases Bilaterally Following Unilateral Striatal GDNF in Aged Rats and Attenuates Nigral Tyrosine Hydroxylase Loss Following 6-OHDA Nigrostriatal Lesion. / 16.10.2019 / PubMed / Full text
• The Gender-Biased Effects of Intranasal MPTP Administration on Anhedonic- and Depressive-Like Behaviors in C57BL/6 Mice: the Role of Neurotrophic Factors. / 11.2018 / PubMed / Full text
• Analysis of neurotrophic and antioxidant factors related to midbrain dopamine neuronal loss and brain inflammation in the cerebrospinal fluid of the elderly. / 09.2018 / PubMed / Full text
• Glial cell line-derived neurotrophic factor (GDNF) attenuates the peripheral neuromuscular dysfunction without inhibiting the activation of spinal microglia/monocyte. / 09.05.2018 / PubMed / Full text
• Aging-related limit of exercise efficacy on motor decline. / 2017 / PubMed / Full text
• The Noradrenergic System of Aged GDNF Heterozygous Mice. / 04.2003 / PubMed / Full text

HDAC1

• HDAC1 modulates OGG1-initiated oxidative DNA damage repair in the aging brain and Alzheimer's disease. / 18.05.2020 / PubMed / Full text
• Loss of genomic integrity induced by lysosphingolipid imbalance drives ageing in the heart. / 04.2019 / PubMed / Full text
• Re-exploring the core genes and modules in the human frontal cortex during chronological aging: insights from network-based analysis of transcriptomic studies. / 20.10.2018 / PubMed / Full text
• Acetylation of PGC1α by Histone Deacetylase 1 Downregulation Is Implicated in Radiation-Induced Senescence of Brain Endothelial Cells. / 16.05.2019 / PubMed / Full text
• Histone deacetylase 1 expression is inversely correlated with age in the short-lived fish Nothobranchius furzeri. / 09.2018 / PubMed / Full text
• Ablation of toll-like receptor 4 attenuates aging-induced myocardial remodeling and contractile dysfunction through NCoRI-HDAC1-mediated regulation of autophagy. / 06.2018 / PubMed / Full text

HDAC2

• EEF1A1 deacetylation enables transcriptional activation of remyelination. / 09.07.2020 / PubMed / Full text
• Endothelial toll-like receptor 4 maintains lung integrity via epigenetic suppression of p16 . / 06.2019 / PubMed / Full text
• Budesonide, Aclidinium and Formoterol in combination limit inflammaging processes in bronchial epithelial cells exposed to cigarette smoke. / 04.2019 / PubMed / Full text
• HDAC3 Regulates the Transition to the Homeostatic Myelinating Schwann Cell State. / 04.12.2018 / PubMed / Full text
• Altered modulation of lamin A/C-HDAC2 interaction and p21 expression during oxidative stress response in HGPS. / 10.2018 / PubMed / Full text
• Histone deacetylase 1 expression is inversely correlated with age in the short-lived fish Nothobranchius furzeri. / 09.2018 / PubMed / Full text

IDH2

• Reactive oxygen species-mediated senescence is accelerated by inhibiting Cdk2 in Idh2-deficient conditions. / 10.09.2019 / PubMed / Full text
• Augmentation of cellular NAD by NQO1 enzymatic action improves age-related hearing impairment. / 10.2019 / PubMed / Full text
• Improving Treatment for Myelodysplastic Syndromes Patients. / 25.10.2018 / PubMed / Full text
• Loss of IDH2 Accelerates Age-related Hearing Loss in Male Mice. / 22.03.2018 / PubMed / Full text
• IDH2-deficient mice develop spinal deformities with aging. / 17.07.2018 / PubMed / Full text
• Idh2 deficiency accelerates renal dysfunction in aged mice. / 04.11.2017 / PubMed / Full text

IGFBP3

• Cellular and Molecular Biomarkers Indicate Premature Aging in Pseudoxanthoma Elasticum Patients. / 05.2020 / PubMed / Full text
• Paracrine senescence of human endometrial mesenchymal stem cells: a role for the insulin-like growth factor binding protein 3. / 17.01.2020 / PubMed / Full text
• Are There Common Mechanisms Between the Hutchinson-Gilford Progeria Syndrome and Natural Aging? / 2019 / PubMed / Full text
• Blunted satellite cell response is associated with dysregulated IGF-1 expression after exercise with age. / 10.2018 / PubMed / Full text
• Systemic analysis of gene expression profiles in porcine granulosa cells during aging. / 14.11.2017 / PubMed / Full text
• G protein-coupled receptor kinase 4-induced cellular senescence and its senescence-associated gene expression profiling. / 15.11.2017 / PubMed / Full text

LBR

• Lamin B receptor: role on chromatin structure, cellular senescence and possibly aging. / 31.07.2020 / PubMed / Full text
• The impact of age beyond ploidy: outcome data from 8175 euploid single embryo transfers. / 03.2020 / PubMed / Full text
• The role of lamin B receptor in the regulation of senescence-associated secretory phenotype (SASP). / 01.05.2020 / PubMed / Full text
• Lamin B receptor plays a key role in cellular senescence induced by inhibition of the proteasome. / 11.12.2019 / PubMed / Full text
• Lamin B receptor (LBR) is involved in the induction of cellular senescence in human cells. / 03.2019 / PubMed / Full text
• Consequences of Lamin B1 and Lamin B Receptor Downregulation in Senescence. / 06.02.2018 / PubMed / Full text

LOX

• 12-LOX catalyzes the oxidation of 2-arachidonoyl-lysolipids in platelets generating eicosanoid-lysolipids that are attenuated by iPLA γ knockout. / 17.04.2020 / PubMed / Full text
• Rice DNA-Binding One Zinc Finger 24 (OsDOF24) Delays Leaf Senescence in a Jasmonate-Mediated Pathway. / 01.09.2019 / PubMed / Full text
• An Adult Drosophila Glioma Model for Studying Pathometabolic Pathways of Gliomagenesis. / 06.2019 / PubMed / Full text
• Suppression of LOX activity enhanced seed vigour and longevity of tobacco ([i]Nicotiana tabacum[/i] L.) seeds during storage. / 2018 / PubMed / Full text
• Dermal Collagen Stabilization by Polyphenols and Spray Drying as an Encapsulation Strategy. / 2018 / PubMed / Full text
• Oxygenation of polyunsaturated fatty acids and oxidative stress within blood platelets. / 06.2018 / PubMed / Full text

MBP

• Demyelination associated with chronic arsenic exposure in Wistar rats. / 15.04.2020 / PubMed / Full text
• Natural killer cells as participants in pathogenesis of rat experimental autoimmune encephalomyelitis (EAE): lessons from research on rats with distinct age and strain. / 2019 / PubMed / Full text
• Whey protein concentrate supplementation protects rat brain against aging-induced oxidative stress and neurodegeneration. / 05.2018 / PubMed / Full text
• Strain specificities in age-related changes in mechanisms promoting and controlling rat spinal cord damage in experimental autoimmune encephalomyelitis. / 01.2018 / PubMed / Full text
• Age-dependent differences in myelin basic protein expression in the hippocampus of young, adult and aged gerbils. / 09.2017 / PubMed / Full text
• Schwann Cell Phenotype Changes in Aging Human Dental Pulp. / 03.2018 / PubMed / Full text

MMP1

• Reacquisition of a spindle cell shape does not lead to the restoration of a youthful state in senescent human skin fibroblasts. / 12.2020 / PubMed / Full text
• A novel multifunctional skin care formulation with a unique blend of antipollution, brightening and antiaging active complexes. / 06.2020 / PubMed / Full text
• Seno-destructive smooth muscle cells in the ascending aorta of patients with bicuspid aortic valve disease. / 05.2019 / PubMed / Full text
• Senescent dermal fibroblasts negatively influence fibroblast extracellular matrix-related gene expression partly via secretion of complement factor D. / 07.2019 / PubMed / Full text
• Ginsenoside Rh2 Ameliorates Doxorubicin-Induced Senescence Bystander Effect in Breast Carcinoma Cell MDA-MB-231 and Normal Epithelial Cell MCF-10A. / 12.03.2019 / PubMed / Full text
• Retinoic acid promotes in vitro follicle activation in the cat ovary by regulating expression of matrix metalloproteinase 9. / 2018 / PubMed / Full text

MMP9

• EGR1 promotes the cartilage degeneration and hypertrophy by activating the Krüppel-like factor 5 and β-catenin signaling. / 01.09.2019 / PubMed / Full text
• [Effect of saponins extracted from Panax japonicas on inhibiting myocardial fibrosis by TGF-β1/Smad3 signaling pathway in aging rats]. / 11.2018 / PubMed / Full text
• Retinoic acid promotes in vitro follicle activation in the cat ovary by regulating expression of matrix metalloproteinase 9. / 2018 / PubMed / Full text
• Oxidative stress induces p38MAPK-dependent senescence in the feto-maternal interface cells. / 07.2018 / PubMed / Full text
• Activation of DNA demethylases attenuates aging-associated arterial stiffening and hypertension. / 08.2018 / PubMed / Full text
• Fibronectin Containing Extra Domain A Induces Plaque Destabilization in the Innominate Artery of Aged Apolipoprotein E-Deficient Mice. / 03.2018 / PubMed / Full text

OGG1

• Advanced Age Is Associated with Iron Dyshomeostasis and Mitochondrial DNA Damage in Human Skeletal Muscle. / 27.11.2019 / PubMed / Full text
• 8-Oxoguanine accumulation in aged female brain impairs neurogenesis in the dentate gyrus and major island of Calleja, causing sexually dimorphic phenotypes. / 09.2019 / PubMed / Full text
• Sirt3 mediates the protective effect of hydrogen in inhibiting ROS-induced retinal senescence. / 01.05.2019 / PubMed / Full text
• [Protective effect of Wuzi Yanzong recipe on testicular DNA oxidative damage in natural ageing rats]. / 07.2018 / PubMed / Full text
• The replicative senescent mesenchymal stem / stromal cells defect in DNA damage response and anti-oxidative capacity. / 2018 / PubMed / Full text
• DNA damage and telomere length shortening in the peripheral blood leukocytes of 20 years SM-exposed veterans. / 08.2018 / PubMed / Full text

PAM

• Relationship between patient activation measurement and self-rated health in patients with chronic diseases. / 04.11.2020 / PubMed / Full text
• Reversal of Age-Related Neuronal Atrophy by α5-GABAA Receptor Positive Allosteric Modulation. / 17.10.2020 / PubMed / Full text
• The ratio of prematurely aging to non-prematurely aging mice cohabiting, conditions their behavior, immunity and lifespan. / 15.06.2020 / PubMed / Full text
• Oxidative-Inflammatory Stress in Immune Cells from Adult Mice with Premature Aging. / 12.02.2019 / PubMed / Full text
• Social environment improves immune function and redox state in several organs from prematurely aging female mice and increases their lifespan. / 02.2019 / PubMed / Full text
• Synergistic enhancing-memory effect of donepezil and S 47445, an AMPA positive allosteric modulator, in middle-aged and aged mice. / 03.2018 / PubMed / Full text

POMC

• Gpr17 deficiency in POMC neurons ameliorates the metabolic derangements caused by long-term high-fat diet feeding. / 14.10.2019 / PubMed / Full text
• Congenital Hypothyroidism is Associated With Impairment of the Leptin Signaling Pathway in the Hypothalamus in Male Wistar Animals in Adult Life. / 05.2019 / PubMed / Full text
• Age-dependent decline of hypothalamic HIF2α in response to insulin and its contribution to advanced age-associated metabolic disorders in mice. / 29.03.2019 / PubMed / Full text
• Prss56 expression in the rodent hypothalamus: Inverse correlation with pro-opiomelanocortin suggests oscillatory gene expression in adult rat tanycytes. / 15.10.2018 / PubMed / Full text
• Chronic treatment with tributyltin induces sexually dimorphic alterations in the hypothalamic POMC system of adult mice. / 12.2018 / PubMed / Full text
• Overexpression of WNK1 in POMC-expressing neurons reduces weigh gain via WNK4-mediated degradation of Kir6.2. / 10.2018 / PubMed / Full text

RIPK1

• Casein kinase 1G2 suppresses necroptosis-promoted testis aging by inhibiting receptor-interacting kinase 3. / 18.11.2020 / PubMed / Full text
• Crucial role of the terminal complement complex in chondrocyte death and hypertrophy after cartilage trauma. / 05.2020 / PubMed / Full text
• RIP kinases as modulators of inflammation and immunity. / 09.2018 / PubMed / Full text
• TBK1 Suppresses RIPK1-Driven Apoptosis and Inflammation during Development and in Aging. / 06.09.2018 / PubMed / Full text
• Necroptosis increases with age and is reduced by dietary restriction. / 08.2018 / PubMed / Full text
• RIPK1-RIPK3-MLKL-dependent necrosis promotes the aging of mouse male reproductive system. / 15.08.2017 / PubMed / Full text

S100B

• Aging protects rat cortical slices against to oxygen-glucose deprivation induced damage. / 12.2020 / PubMed / Full text
• The Role of S100B in Aerobic Training Efficacy in Older Adults with Mild Vascular Cognitive Impairment: Secondary Analysis of a Randomized Controlled Trial. / 01.07.2019 / PubMed / Full text
• Changes in mechanoreceptors in rabbits' anterior cruciate ligaments with age. / 06.2019 / PubMed / Full text
• Towards frailty biomarkers: Candidates from genes and pathways regulated in aging and age-related diseases. / 11.2018 / PubMed / Full text
• DNA methylation analysis on purified neurons and glia dissects age and Alzheimer's disease-specific changes in the human cortex. / 25.07.2018 / PubMed / Full text
• Proteome profiling in the hippocampus, medial prefrontal cortex, and striatum of aging rat. / 01.10.2018 / PubMed / Full text

SIRT4

• Novel role of the SIRT4-OPA1 axis in mitochondrial quality control. / 23.12.2017 / PubMed / Full text
• Mitochondrial Function, Metabolic Regulation, and Human Disease Viewed through the Prism of Sirtuin 4 (SIRT4) Functions. / 03.05.2019 / PubMed / Full text
• Loss of mitochondrial SIRT4 shortens lifespan and leads to a decline in physical activity. / 06.2018 / PubMed
• SIRT4 is essential for metabolic control and meiotic structure during mouse oocyte maturation. / 08.2018 / PubMed / Full text
• Differential gene expression of sirtuins between somatotropinomas and nonfunctioning pituitary adenomas. / 08.2018 / PubMed / Full text
• SIRT4 interacts with OPA1 and regulates mitochondrial quality control and mitophagy. / 29.10.2017 / PubMed / Full text

SIRT7

• SIRT7 antagonizes human stem cell aging as a heterochromatin stabilizer. / 07.2020 / PubMed / Full text
• Spatio-temporal expression profile of sirtuins during aging of the annual fish Nothobranchius furzeri. / 09.2019 / PubMed / Full text
• Advances in Cellular Characterization of the Sirtuin Isoform, SIRT7. / 2018 / PubMed / Full text
• The epigenetic regulator SIRT7 guards against mammalian cellular senescence induced by ribosomal DNA instability. / 13.07.2018 / PubMed / Full text
• Differential gene expression of sirtuins between somatotropinomas and nonfunctioning pituitary adenomas. / 08.2018 / PubMed / Full text
• Analysis of Polymorphisms in 59 Potential Candidate Genes for Association With Human Longevity. / 08.10.2018 / PubMed / Full text

SQSTM1

• The selective autophagy receptor SQSTM1/p62 improves lifespan and proteostasis in an evolutionarily conserved manner. / 04.2020 / PubMed / Full text
• SIRT2 functions in aging, autophagy, and apoptosis in post-maturation bovine oocytes. / 01.09.2019 / PubMed / Full text
• A pH probe inhibits senescence in mesenchymal stem cells. / 07.12.2018 / PubMed / Full text
• The ATG5-binding and coiled coil domains of ATG16L1 maintain autophagy and tissue homeostasis in mice independently of the WD domain required for LC3-associated phagocytosis. / 04.2019 / PubMed / Full text
• Systemic overexpression of SQSTM1/p62 accelerates disease onset in a SOD1 -expressing ALS mouse model. / 29.05.2018 / PubMed / Full text
• SIRT6 histone deacetylase functions as a potential oncogene in human melanoma. / 09.2017 / PubMed / Full text

TLR9

• Age-Associated B Cells. / 26.04.2020 / PubMed / Full text
• Inhibition of TLR9 attenuates skeletal muscle fibrosis in aged sarcopenic mice via the p53/SIRT1 pathway. / 15.07.2019 / PubMed / Full text
• Novel molecular mechanisms for the adaptogenic effects of herbal extracts on isolated brain cells using systems biology. / 15.11.2018 / PubMed / Full text
• B cell responses to apoptotic cells in MFG-E8-/- mice. / 2018 / PubMed / Full text
• Sirtuin 1-Chromatin-Binding Dynamics Points to a Common Mechanism Regulating Inflammatory Targets in SIV Infection and in the Aging Brain. / 06.2018 / PubMed / Full text
• Decreased NLRP3 inflammasome expression in aged lung may contribute to increased susceptibility to secondary Streptococcus pneumoniae infection. / 05.2018 / PubMed / Full text

TPR

• Catalytic Performances of Cu/MCM-22 Zeolites with Different Cu Loadings in NH -SCR. / 30.10.2020 / PubMed / Full text
• Do traits of plant species predict the efficacy of species distribution models for finding new occurrences? / 06.2020 / PubMed / Full text
• In-situ modified the surface of Pt-doped perovskite catalyst for soot oxidation. / 05.02.2020 / PubMed / Full text
• Nuclear pore density controls heterochromatin reorganization during senescence. / 01.02.2019 / PubMed / Full text
• Spontaneous mutations in [i]CYC8[/i] and [i]MIG1[/i] suppress the short chronological lifespan of budding yeast lacking SNF1/AMPK. / 19.02.2018 / PubMed / Full text
• Genome-wide association study and annotating candidate gene networks affecting age at first calving in Nellore cattle. / 12.2017 / PubMed / Full text

TXNIP

• Panax notoginseng saponins attenuate neuroinflammation through TXNIP-mediated NLRP3 inflammasome activation in aging rats. / 10.11.2020 / PubMed / Full text
• Redox homeostasis and cell cycle activation mediate beta-cell mass expansion in aged, diabetes-prone mice under metabolic stress conditions: Role of thioredoxin-interacting protein (TXNIP). / 07.10.2020 / PubMed / Full text
• [Effect of diabetic induced thioredoxin interacting protein (TXNIP) on islet cell senescence]. / 03.2020 / PubMed / Full text
• PRMT5-TRIM21 interaction regulates the senescence of osteosarcoma cells by targeting the TXNIP/p21 axis. / 05.02.2020 / PubMed / Full text
• TXNIP regulates AKT-mediated cellular senescence by direct interaction under glucose-mediated metabolic stress. / 12.2018 / PubMed / Full text
• Enhanced expression of thioredoxin-interacting-protein regulates oxidative DNA damage and aging. / 07.2018 / PubMed / Full text

VIP

• Alterations in Intrinsic and Synaptic Properties of Hippocampal CA1 VIP Interneurons During Aging. / 2020 / PubMed / Full text
• Nutrition and exercise interventions could ameliorate age-related cognitive decline: a meta-analysis of randomized controlled trials. / 14.10.2020 / PubMed / Full text
• Neuropeptide changes in the suprachiasmatic nucleus are associated with the development of hypertension. / 08.2019 / PubMed / Full text
• The Alabama VIP older driver study rationale and design: examining the relationship between vision impairment and driving using naturalistic driving techniques. / 07.02.2018 / PubMed / Full text
• Aging-Induced Modulation of Pituitary Adenylate Cyclase-Activating Peptide- and Vasoactive Intestinal Peptide-Induced Vasomotor Responses in the Arteries of Mice. / 2017 / PubMed / Full text
• Ontogeny of Circadian Rhythms and Synchrony in the Suprachiasmatic Nucleus. / 07.02.2018 / PubMed / Full text

ABO

• Allelic distribution of [i]ABO[/i] gene in Chinese centenarians. / 09.2020 / PubMed / Full text
• Genetically Determined ABO Blood Group and its Associations With Health and Disease. / 03.2020 / PubMed / Full text
• Plasma proteomic and autoantibody profiles reveal the proteomic characteristics involved in longevity families in Bama, China. / 2019 / PubMed / Full text
• Recipients with blood group A associated with longer survival rates in cardiac valvular bioprostheses. / 04.2019 / PubMed / Full text
• ABO blood group polymorphism has an impact on prostate, kidney and bladder cancer in association with longevity. / 07.2018 / PubMed / Full text

ACR

• Progenitor cell niche senescence reflects pathology of the parotid salivary gland in primary Sjögren's syndrome. / 01.10.2020 / PubMed / Full text
• Jumping Joints: The Complex Relationship Between Osteoarthritis and Jumping Mechanography. / 02.2020 / PubMed / Full text
• Hospitalization Risk among Older Adults with Chronic Kidney Disease. / 2019 / PubMed / Full text
• Longitudinal association of carotid endothelial shear stress with renal function decline in aging adults with normal renal function: A population-based cohort study. / 14.02.2019 / PubMed / Full text
• Albumin-to-creatinine ratio as a predictor of all-cause mortality and hospitalization of congestive heart failure in Chinese elder hypertensive patients with high cardiovascular risks. / 2018 / PubMed / Full text

AVP

• Plasma oxytocin and vasopressin levels in young and older men and women: Functional relationships with attachment and cognition. / 12.2019 / PubMed / Full text
• Pathophysiological Mechanisms of Nocturia and Nocturnal Polyuria: The Contribution of Cellular Function, the Urinary Bladder Urothelium, and Circadian Rhythm. / 11.2019 / PubMed / Full text
• Neuropeptide changes in the suprachiasmatic nucleus are associated with the development of hypertension. / 08.2019 / PubMed / Full text
• The effects of aging on biosynthetic processes in the rat hypothalamic osmoregulatory neuroendocrine system. / 05.2018 / PubMed / Full text
• Copeptin and insulin resistance: effect modification by age and 11 β-HSD2 activity in a population-based study. / 07.2018 / PubMed / Full text

BRD4

• Inhibition of BRD4 triggers cellular senescence through suppressing aurora kinases in oesophageal cancer cells. / 20.09.2020 / PubMed / Full text
• BRD4 contributes to LPS-induced macrophage senescence and promotes progression of atherosclerosis-associated lipid uptake. / 11.05.2020 / PubMed / Full text
• BET Proteins Are Required for Transcriptional Activation of the Senescent Islet Cell Secretome in Type 1 Diabetes. / 26.09.2019 / PubMed / Full text
• Interference with the bromodomain epigenome readers drives p21 expression and tumor senescence. / 01.10.2019 / PubMed / Full text
• Neuroprotective effects of targeting BET proteins for degradation with dBET1 in aged mice subjected to ischemic stroke. / 07.2019 / PubMed / Full text

C5

• The C5-75 Program: Meeting the Need for Efficient, Pragmatic Frailty Screening and Management in Primary Care. / 23.06.2020 / PubMed / Full text
• Can a relatively large spinal cord for the dural sac influence severity of paralysis in elderly patients with cervical spinal cord injury caused by minor trauma? / 26.06.2020 / PubMed / Full text
• Age and Sex-Associated Changes of Complement Activity and Complement Levels in a Healthy Caucasian Population. / 2018 / PubMed / Full text
• Longevity of adenovirus vector immunity in mice and its implications for vaccine efficacy. / 29.10.2018 / PubMed / Full text
• Generating Rasch-based activity of daily living measures from the Spinal Cord Injury Longitudinal Aging Study. / 01.2018 / PubMed / Full text

C7

• The Vertebral Artery Convergence to the Cervical Spine in Elders. / 30.09.2019 / PubMed / Full text
• Age-related Changes in Cervical Sagittal Alignment: A Radiographic Analysis. / 01.10.2019 / PubMed / Full text
• Early Intravenous Infusion of Mesenchymal Stromal Cells Exerts a Tissue Source Age-Dependent Beneficial Effect on Neurovascular Integrity and Neurobehavioral Recovery After Traumatic Cervical Spinal Cord Injury. / 07.2019 / PubMed / Full text
• Age and Sex-Associated Changes of Complement Activity and Complement Levels in a Healthy Caucasian Population. / 2018 / PubMed / Full text
• Twenty-year Longitudinal Follow-up MRI Study of Asymptomatic Volunteers: The Impact of Cervical Alignment on Disk Degeneration. / 12.2018 / PubMed / Full text

CCL4

• Microglial translational profiling reveals a convergent APOE pathway from aging, amyloid, and tau. / 03.09.2018 / PubMed / Full text
• Time-Dependent Changes in Local and Serum Levels of Inflammatory Cytokines as Markers for Incised Wound Aging of Skeletal Muscles. / 05.2018 / PubMed / Full text
• Human Body Composition and Immunity: Visceral Adipose Tissue Produces IL-15 and Muscle Strength Inversely Correlates with NK Cell Function in Elderly Humans. / 2018 / PubMed / Full text
• Age-related pro-inflammatory and pro-angiogenic changes in human aqueous humor. / 2018 / PubMed / Full text
• Age-related decline of the acute local inflammation response: a mitigating role for the adenosine A receptor. / 18.10.2017 / PubMed / Full text

CCR7

• Are skin senescence and immunosenescence linked within individuals? / 08.2019 / PubMed / Full text
• CCL21/CCR7 axis regulating juvenile cartilage repair can enhance cartilage healing in adults. / 26.03.2019 / PubMed / Full text
• Low IL-2 Expressing T Cells in Thalassemia Major Patients: Is It Immune Aging. / 10.2018 / PubMed / Full text
• Abnormalities of age-related T cell senescence in Parkinson's disease. / 28.05.2018 / PubMed / Full text
• Effects of lifelong training on senescence and mobilization of T lymphocytes in response to acute exercise. / 2018 / PubMed

CD163

• Complement Inhibition Attenuates Early Erythrolysis in the Hematoma and Brain Injury in Aged Rats. / 07.2019 / PubMed / Full text
• Increased monocyte activation with age among HIV-infected long term non-progressor children: implications for early treatment initiation. / 09.2019 / PubMed / Full text
• Age Influences Microglial Activation After Cuprizone-Induced Demyelination. / 2018 / PubMed / Full text
• Age-related M1/M2 phenotype changes in circulating monocytes from healthy/unhealthy individuals. / 08.06.2018 / PubMed / Full text
• Distinct effect of age, sex, and CMV seropositivity on dendritic cells and monocytes in human blood. / 01.2018 / PubMed / Full text

CD69

• CD8 HLADR Regulatory T Cells Change With Aging: They Increase in Number, but Lose Checkpoint Inhibitory Molecules and Suppressive Function. / 2018 / PubMed / Full text
• Differential Impact of Obesity on CD69 Expression in Individuals with Bipolar Disorder and Healthy Controls. / 05.2018 / PubMed / Full text
• An immunological age index in bipolar disorder: A confirmatory factor analysis of putative immunosenescence markers and associations with clinical characteristics. / 12.2018 / PubMed / Full text
• Differences Between Pediatric and Adult T Cell Responses to [i]In Vitro[/i] Staphylococcal Enterotoxin B Stimulation. / 2018 / PubMed / Full text
• Associations between immunological function and memory recall in healthy adults. / 12.2017 / PubMed / Full text

CD80

• The aging common marmoset's immune system: From junior to senior. / 06.2020 / PubMed / Full text
• [i]Akkermansia muciniphila[/i] ameliorates the age-related decline in colonic mucus thickness and attenuates immune activation in accelerated aging [i]Ercc1[/i] mice. / 2019 / PubMed / Full text
• The Regulatory Status Adopted by Lymph Node Dendritic Cells and T Cells During Healthy Aging Is Maintained During Cancer and May Contribute to Reduced Responses to Immunotherapy. / 2018 / PubMed / Full text
• Age-related M1/M2 phenotype changes in circulating monocytes from healthy/unhealthy individuals. / 08.06.2018 / PubMed / Full text
• Elderly dendritic cells respond to LPS/IFN-γ and CD40L stimulation despite incomplete maturation. / 2018 / PubMed / Full text

CD86

• Iso-α-acids, Hop-Derived Bitter Components of Beer, Attenuate Age-Related Inflammation and Cognitive Decline. / 2019 / PubMed / Full text
• Age-associated antigen-presenting cell alterations promote dry-eye inducing Th1 cells. / 07.2019 / PubMed / Full text
• One-Year Consumption of a Mediterranean-Like Dietary Pattern With Vitamin D3 Supplements Induced Small Scale but Extensive Changes of Immune Cell Phenotype, Co-receptor Expression and Innate Immune Responses in Healthy Elderly Subjects: Results From the United Kingdom Arm of the NU-AGE Trial. / 2018 / PubMed / Full text
• C-Reactive Protein Impairs Dendritic Cell Development, Maturation, and Function: Implications for Peripheral Tolerance. / 2018 / PubMed / Full text
• Immunoglobulin therapy ameliorates the phenotype and increases lifespan in the severely affected dystrophin-utrophin double knockout mice. / 12.2017 / PubMed / Full text

CDA

• Cumulative Dis/Advantage and Health Pattern in Late Life: A Comparison between Genders and Welfare State Regimes. / 2019 / PubMed / Full text
• Does numerical similarity alter age-related distractibility in working memory? / 2019 / PubMed / Full text
• Can working memory capacity be expanded by boosting working memory updating efficiency in older adults? / 12.2018 / PubMed / Full text
• Negative Affect Influences Electrophysiological Markers of Visual Working Memory in Mildly Stressed Older Adults. / 2018 / PubMed / Full text
• EEG correlates of visual short-term memory in older age vary with adult lifespan cognitive development. / 02.2018 / PubMed / Full text

CLU

• Expression of Clusterin suppresses Cr(VI)-induced premature senescence through activation of PI3K/AKT pathway. / 15.11.2019 / PubMed / Full text
• Informative combination of CLU rs11136000, serum HDL levels, diabetes, and age as a new piece of puzzle-picture of predictive medicine for cognitive disorders. / 02.2019 / PubMed / Full text
• Integrative transcriptome analyses of the aging brain implicate altered splicing in Alzheimer's disease susceptibility. / 11.2018 / PubMed / Full text
• DNA methylation analysis on purified neurons and glia dissects age and Alzheimer's disease-specific changes in the human cortex. / 25.07.2018 / PubMed / Full text
• Recent studies on cellular and molecular mechanisms in Alzheimer's disease: focus on epigenetic factors and histone deacetylase. / 28.03.2018 / PubMed / Full text

CSF1R

• CSF1R inhibitor PLX5622 and environmental enrichment additively improve metabolic outcomes in middle-aged female mice. / 02.02.2020 / PubMed / Full text
• Modulation of Microglia by Voluntary Exercise or CSF1R Inhibition Prevents Age-Related Loss of Functional Motor Units. / 05.11.2019 / PubMed / Full text
• Forced turnover of aged microglia induces an intermediate phenotype but does not rebalance CNS environmental cues driving priming to immune challenge. / 26.11.2018 / PubMed / Full text
• Replacement of microglia in the aged brain reverses cognitive, synaptic, and neuronal deficits in mice. / 12.2018 / PubMed / Full text
• Mendelian adult-onset leukodystrophy genes in Alzheimer's disease: critical influence of CSF1R and NOTCH3. / 06.2018 / PubMed / Full text

CXCL9

• CXCL9 and CXCL10 display an age-dependent profile in Chagas patients: a cohort study of aging in Bambui, Brazil. / 11.05.2020 / PubMed / Full text
• Inflammatory markers and occurrence of falls: Bambuí Cohort Study of Aging. / 01.04.2019 / PubMed / Full text
• Age-related pro-inflammatory and pro-angiogenic changes in human aqueous humor. / 2018 / PubMed / Full text
• Immune senescence and biomarkers profile of Bambuí aged population-based cohort. / 03.2018 / PubMed / Full text
• Predictive value of multiple cytokines and chemokines for mortality in an admixed population: 15-year follow-up of the Bambui-Epigen (Brazil) cohort study of aging. / 11.2017 / PubMed / Full text

CYP11A1

• Prepubertal exposure to perfluorononanoic acid interferes with spermatogenesis and steroidogenesis in male mice. / 15.04.2019 / PubMed / Full text
• Morphological rearrangement of the cortical region, in aging ovaries. / 07.2019 / PubMed / Full text
• Peroxiredoxin 2 deficiency accelerates age-related ovarian failure through the reactive oxygen species-mediated JNK pathway in mice. / 01.08.2018 / PubMed / Full text
• Systemic analysis of gene expression profiles in porcine granulosa cells during aging. / 14.11.2017 / PubMed / Full text
• Combined toxicity of endosulfan and phenanthrene mixtures and induced molecular changes in adult Zebrafish (Danio rerio). / 03.2018 / PubMed / Full text

DCN

• Decorin inhibits the insulin-like growth factor I signaling in bone marrow mesenchymal stem cells of aged humans. / 26.11.2020 / PubMed / Full text
• The beneficial effects of 15 units of high-intensity circuit training in women is modified by age, baseline insulin resistance and physical capacity. / 06.2019 / PubMed / Full text
• MicroRNA-143-5p targeting eEF2 gene mediates intervertebral disc degeneration through the AMPK signaling pathway. / 15.04.2019 / PubMed / Full text
• Does Age Interfere With Gadolinium Toxicity and Presence in Brain and Bone Tissues?: A Comparative Gadoterate Versus Gadodiamide Study in Juvenile and Adult Rats. / 02.2019 / PubMed / Full text
• Extracellular proteoglycan decorin maintains human hair follicle stem cells. / 12.2018 / PubMed / Full text

DNMT1

• DNA Methyltransferase 1 (DNMT1) Function Is Implicated in the Age-Related Loss of Cortical Interneurons. / 2020 / PubMed / Full text
• Age-related Changes in the Global DNA Methylation Profile of Oligodendrocyte Progenitor Cells Derived from Rat Spinal Cords. / 02.2019 / PubMed / Full text
• Epigallocatechin-3-gallate and BIX-01294 have different impact on epigenetics and senescence modulation in acute and chronic myeloid leukemia cells. / 05.11.2018 / PubMed / Full text
• Resveratrol promotes oxidative stress to drive DLC1 mediated cellular senescence in cancer cells. / 15.09.2018 / PubMed / Full text
• Ultraviolet A irradiation induces senescence in human dermal fibroblasts by down-regulating DNMT1 via ZEB1. / 16.02.2018 / PubMed / Full text

ECD

• Outcome of Descemet Membrane Endothelial Keratoplasty Using Corneas from Donors ≥80 Years of Age. / 03.2020 / PubMed / Full text
• The occurrence and dynamics of polychlorinated hydrocarbons in roe deer ([i]Capreolus capreolus[/i]) in South-western Slovakia. / 2019 / PubMed / Full text
• Corneal thickness, endothelial cell density, and morphological and morphometric features of corneal endothelial cells in goats. / 10.2018 / PubMed / Full text
• Endothelial cell density and characterization of corneal endothelial cells in the Tawny Owl (Strix aluco) using specular microscopy. / 03.2019 / PubMed / Full text
• An autopsy case report: Differences in radiological images correlate with histology in Erdheim-Chester disease. / 06.2018 / PubMed / Full text

EGR1

• Glucocorticoids delay RAF-induced senescence promoted by EGR1. / 22.08.2019 / PubMed / Full text
• EGR1 promotes the cartilage degeneration and hypertrophy by activating the Krüppel-like factor 5 and β-catenin signaling. / 01.09.2019 / PubMed / Full text
• Identification of key genes and transcription factors in aging mesenchymal stem cells by DNA microarray data. / 15.04.2019 / PubMed / Full text
• Hypoxia-inducible transcription factors, HIF1A and HIF2A, increase in aging mucosal tissues. / 07.2018 / PubMed / Full text
• The p16/miR-217/EGR1 pathway modulates age-related tenogenic differentiation in tendon stem/progenitor cells. / 01.11.2017 / PubMed / Full text

EPO

• Regulation of muscle and metabolic physiology by hypothalamic erythropoietin independently of its peripheral action. / 02.2020 / PubMed / Full text
• Red Blood Cell Lifespan Shortening in Patients with Early-Stage Chronic Kidney Disease. / 2019 / PubMed / Full text
• Age-Dependent Systemic Effects of a Systemic Intermittent Hypoxic Therapy [i]In Vivo[/i]. / 09.2019 / PubMed / Full text
• Erythropoietin does not improve fracture healing in aged mice. / 15.07.2019 / PubMed / Full text
• Dose-response relationship of intermittent normobaric hypoxia to stimulate erythropoietin in the context of health promotion in young and old people. / 05.2019 / PubMed / Full text

F5

• Methylation signatures in peripheral blood are associated with marked age acceleration and disease progression in patients with primary sclerosing cholangitis. / 02.2020 / PubMed / Full text
• Fermentation of Blackberry with [i]L. plantarum[/i] JBMI F5 Enhance the Protection Effect on UVB-Mediated Photoaging in Human Foreskin Fibroblast and Hairless Mice through Regulation of MAPK/NF-κB Signaling. / 11.10.2019 / PubMed / Full text
• Proof of concept study of age-dependent DNA methylation markers across different tissues by massive parallel sequencing. / 09.2018 / PubMed / Full text
• Multigenerational effects of 4-methylbenzylidene camphor (4-MBC) on the survival, development and reproduction of the marine copepod Tigriopus japonicus. / 01.2018 / PubMed / Full text
• Chronological age prediction based on DNA methylation: Massive parallel sequencing and random forest regression. / 11.2017 / PubMed / Full text

FGFR1

• Alignment of Alzheimer's disease amyloid β-peptide and klotho. / 11-12.2020 / PubMed / Full text
• Satellite cell-specific ablation of Cdon impairs integrin activation, FGF signalling, and muscle regeneration. / 08.2020 / PubMed / Full text
• Systemic administration of a fibroblast growth factor receptor 1 agonist rescues the cognitive deficit in aged socially isolated rats. / 06.2019 / PubMed / Full text
• Impact of aging and caloric restriction on fibroblast growth factor 21 signaling in rat white adipose tissue. / 04.2019 / PubMed / Full text
• Activity-dependent neuronal Klotho enhances astrocytic aerobic glycolysis. / 08.2019 / PubMed / Full text

FSHR

• FSHR ablation induces depression-like behaviors. / 08.2020 / PubMed / Full text
• Direct actions of gonadotropins beyond the reproductive system and their role in human aging and neoplasia [Bezpośrednie działanie gonadotropin poza układem rozrodczym i ich rola w starzeniu się i nowotworzeniu u człowieka]. / 2019 / PubMed / Full text
• Follicle-stimulating hormone promotes renal tubulointerstitial fibrosis in aging women via the AKT/GSK-3β/β-catenin pathway. / 10.2019 / PubMed / Full text
• Growth hormone during in vitro fertilization in older women modulates the density of receptors in granulosa cells, with improved pregnancy outcomes. / 12.2018 / PubMed / Full text
• Diurnal rhythm of follicle-stimulating hormone is associated with nonalcoholic fatty liver disease in a Chinese elderly population. / 03.2018 / PubMed / Full text

FUS

• HPV shapes tumor transcriptome by globally modifying the pool of RNA binding protein-binding motif. / 29.04.2019 / PubMed / Full text
• Memory Decline and Its Reversal in Aging and Neurodegeneration Involve miR-183/96/182 Biogenesis. / 05.2019 / PubMed / Full text
• [Development of imaging-based diagnostic procedures for brain protein aging using a mouse model of tauopathy]. / 2018 / PubMed / Full text
• Riluzole does not improve lifespan or motor function in three ALS mouse models. / 08.2018 / PubMed / Full text
• Investigation of the Safety of Focused Ultrasound-Induced Blood-Brain Barrier Opening in a Natural Canine Model of Aging. / 2017 / PubMed / Full text

GCA

• Familial aggregation of longevity in giant cell arteritis and polymyalgia rheumatica. / 12.2020 / PubMed / Full text
• Interaction between Alcohol Consumption and Apolipoprotein E (ApoE) Genotype with Cognition in Middle-Aged Men. / 14.07.2020 / PubMed / Full text
• Influence of young adult cognitive ability and additional education on later-life cognition. / 05.02.2019 / PubMed / Full text
• Altered effective connectivity anchored in the posterior cingulate cortex and the medial prefrontal cortex in cognitively intact elderly APOE ε4 carriers: a preliminary study. / 02.2019 / PubMed / Full text
• Global Cerebral Atrophy Detected by Routine Imaging: Relationship with Age, Hippocampal Atrophy, and White Matter Hyperintensities. / 05.2018 / PubMed / Full text

GHR

• Tissue-Specific GHR Knockout Mice: An Updated Review. / 2020 / PubMed / Full text
• The mir-465 family is upregulated with age and attenuates growth hormone signaling in mouse liver. / 04.2019 / PubMed / Full text
• Growth hormone during in vitro fertilization in older women modulates the density of receptors in granulosa cells, with improved pregnancy outcomes. / 12.2018 / PubMed / Full text
• Effects of rapamycin on growth hormone receptor knockout mice. / 13.02.2018 / PubMed / Full text
• Disruption of the GH receptor gene in adult mice and in insulin sensitive tissues. / 02.2018 / PubMed / Full text

GHRH

• Physiological and metabolic features of mice with CRISPR/Cas9-mediated loss-of-function in growth hormone-releasing hormone. / 18.05.2020 / PubMed / Full text
• Transcriptomic and metabolomic profiling of long-lived growth hormone releasing hormone knock-out mice: evidence for altered mitochondrial function and amino acid metabolism. / 23.02.2020 / PubMed / Full text
• Roles of peptides and steroids in sleep disorders. / 09.2006 / PubMed / Full text
• Growth Hormone Deficiency: Health and Longevity. / 01.04.2019 / PubMed / Full text
• Aromatized Estrogens Amplify Nocturnal Growth Hormone Secretion in Testosterone-Replaced Older Hypogonadal Men. / 01.12.2018 / PubMed / Full text

GIP

• Absence of GIP secretion alleviates age-related obesity and insulin resistance. / 04.2020 / PubMed / Full text
• Inhibition of GIP signaling extends lifespan without caloric restriction. / 11.06.2019 / PubMed / Full text
• Transcriptional factor Pdx1 is involved in age-related GIP hypersecretion in mice. / 01.08.2018 / PubMed / Full text
• Older Subjects With β-Cell Dysfunction Have an Accentuated Incretin Release. / 01.07.2018 / PubMed / Full text
• Effect of Age on Blood Glucose and Plasma Insulin, Glucagon, Ghrelin, CCK, GIP, and GLP-1 Responses to Whey Protein Ingestion. / 21.12.2017 / PubMed / Full text

GRN

• Stressful development: Integrating endoderm development, stress, and longevity. / 08.12.2020 / PubMed / Full text
• A Scoping Review of the Evidence About the Nurses Improving Care for Healthsystem Elders (NICHE) Program. / 04.11.2019 / PubMed / Full text
• Methods to Investigate the Molecular Basis of Progranulin Actions on Brain and Behavior In Vivo Using Knockout Mice. / 2018 / PubMed / Full text
• Combined Pathologies in FTLD-TDP Types A and C. / 01.05.2018 / PubMed / Full text
• A potent tilapia secreted granulin peptide enhances the survival of transgenic zebrafish infected by Vibrio vulnificus via modulation of innate immunity. / 04.2018 / PubMed / Full text

HDAC6

• Inhibition of HDAC6 Attenuates Diabetes-Induced Retinal Redox Imbalance and Microangiopathy. / 09.07.2020 / PubMed / Full text
• Cellular senescence is associated with reorganization of the microtubule cytoskeleton. / 03.2019 / PubMed / Full text
• 2,4‑Di‑tert‑butylphenol, a potential HDAC6 inhibitor, induces senescence and mitotic catastrophe in human gastric adenocarcinoma AGS cells. / 05.2018 / PubMed / Full text
• HDAC6 Suppresses Age-Dependent Ectopic Fat Accumulation by Maintaining the Proteostasis of PLIN2 in Drosophila. / 09.10.2017 / PubMed / Full text
• The Deacetylase HDAC6 Mediates Endogenous Neuritic Tau Pathology. / 29.08.2017 / PubMed / Full text

HTT

• Biological Aging and the Cellular Pathogenesis of Huntington's Disease. / 2020 / PubMed / Full text
• Striatal Mutant Huntingtin Protein Levels Decline with Age in Homozygous Huntington's Disease Knock-In Mouse Models. / 2018 / PubMed / Full text
• Early Neurodegeneration in R6/2 Mice Carrying the Huntington's Disease Mutation with a Super-Expanded CAG Repeat, Despite Normal Lifespan. / 2018 / PubMed / Full text
• Striatal neurons directly converted from Huntington's disease patient fibroblasts recapitulate age-associated disease phenotypes. / 03.2018 / PubMed / Full text
• Cell-to-cell Transmission of Polyglutamine Aggregates in [i]C. elegans[/i]. / 12.2017 / PubMed / Full text

IGF1R

• Comparison of mitochondrial transplantation by using a stamp-type multineedle injector and platelet-rich plasma therapy for hair aging in naturally aging mice. / 10.2020 / PubMed / Full text
• In mice transgenic for IGF1 under keratin-14 promoter, lifespan is decreased and the rates of aging and thymus involution are accelerated. / 13.04.2019 / PubMed / Full text
• Insulin/IGF-1 signaling and aging. / 09.2016 / PubMed
• Effect of young exosomes injected in aged mice. / 2018 / PubMed / Full text
• The genetic component of human longevity: New insights from the analysis of pathway-based SNP-SNP interactions. / 06.2018 / PubMed / Full text

KEAP1

• NRF2 pathway activation by KEAP1 inhibition attenuates the manifestation of aging phenotypes in salivary glands. / 09.2020 / PubMed / Full text
• Adaptation of the master antioxidant response connects metabolism, lifespan and feather development pathways in birds. / 18.05.2020 / PubMed / Full text
• Inflammatory and Senescent Phenotype of Pancreatic Stellate Cells Induced by Sqstm1 Downregulation Facilitates Pancreatic Cancer Progression. / 2019 / PubMed / Full text
• Systemic overexpression of SQSTM1/p62 accelerates disease onset in a SOD1 -expressing ALS mouse model. / 29.05.2018 / PubMed / Full text
• Sulfur amino acid restriction-induced changes in redox-sensitive proteins are associated with slow protein synthesis rates. / 04.2018 / PubMed / Full text

LMNB1

• SIRT1 - a new mammalian substrate of nuclear autophagy. / 08.12.2020 / PubMed / Full text
• Cellular senescence as a response to multiwalled carbon nanotube (MWCNT) exposure in human mesothelial cells. / 03.12.2020 / PubMed / Full text
• Inflammatory Drivers of Cardiovascular Disease: Molecular Characterization of Senescent Coronary Vascular Smooth Muscle Cells. / 2020 / PubMed / Full text
• Neuronal [i]Lamin[/i] regulates motor circuit integrity and controls motor function and lifespan. / 17.08.2018 / PubMed / Full text
• KMT1 family methyltransferases regulate heterochromatin-nuclear periphery tethering via histone and non-histone protein methylation. / 05.2019 / PubMed / Full text

LPP

• Effects of lifelong intake of lemon polyphenols on aging and intestinal microbiome in the senescence-accelerated mouse prone 1 (SAMP1). / 06.03.2019 / PubMed / Full text
• Age differences in the neural correlates underlying control of emotional memory: An event-related potential study. / 15.10.2018 / PubMed / Full text
• The Influence of Emotional Material on Encoding and Retrieving Intentions: An ERP Study in Younger and Older Adults. / 2018 / PubMed / Full text
• Convergence of BOLD and ERP measures of neural reactivity to emotional faces in children and adolescents with and without anxiety disorders. / 04.2018 / PubMed / Full text
• Urethral function and histopathology in aged female rats as a stress urinary incontinence model. / 04.2019 / PubMed / Full text

MAP2

• Protective effects of ischemic preconditioning against neuronal apoptosis and dendritic injury in the hippocampus are age-dependent. / 11.2020 / PubMed / Full text
• SerThr-PhosphoProteome of Brain from Aged PINK1-KO+A53T-SNCA Mice Reveals pT1928-MAP1B and pS3781-ANK2 Deficits, as Hub between Autophagy and Synapse Changes. / 04.07.2019 / PubMed / Full text
• DNA methylation analysis on purified neurons and glia dissects age and Alzheimer's disease-specific changes in the human cortex. / 25.07.2018 / PubMed / Full text
• Systemic overexpression of SQSTM1/p62 accelerates disease onset in a SOD1 -expressing ALS mouse model. / 29.05.2018 / PubMed / Full text
• Long-term treadmill exercise improves memory impairment through restoration of decreased synaptic adhesion molecule 1/2/3 induced by transient cerebral ischemia in the aged gerbil hippocampus. / 03.2018 / PubMed / Full text

MECP2

• Senescence Phenomena and Metabolic Alteration in Mesenchymal Stromal Cells from a Mouse Model of Rett Syndrome. / 21.05.2019 / PubMed / Full text
• A Novel Mecp2 Knock-in Model Displays Similar Behavioral Traits But Distinct Molecular Features Compared to the Mecp2-Null Mouse Implying Precision Medicine for the Treatment of Rett Syndrome. / 07.2019 / PubMed / Full text
• Tsix-Mecp2 female mouse model for Rett syndrome reveals that low-level MECP2 expression extends life and improves neuromotor function. / 07.08.2018 / PubMed / Full text
• Epilepsy in classic Rett syndrome: Course and characteristics in adult age. / 09.2018 / PubMed / Full text
• Loss of MECP2 Leads to Activation of P53 and Neuronal Senescence. / 08.05.2018 / PubMed / Full text

MGMT

• Cytotoxic and Senolytic Effects of Methadone in Combination with Temozolomide in Glioblastoma Cells. / 23.09.2020 / PubMed / Full text
• Profound, durable and MGMT-independent sensitivity of glioblastoma cells to cyclin-dependent kinase inhibition. / 01.07.2019 / PubMed / Full text
• Influence of aging in the modulation of epigenetic biomarkers of carcinogenesis after exposure to air pollution. / 09.2018 / PubMed / Full text
• Integrated study on comparative transcriptome and skeletal muscle function in aged rats. / 01.2018 / PubMed / Full text
• Proteomics and metabolomics identify molecular mechanisms of aging potentially predisposing for chronic lymphocytic leukemia. / 02.2018 / PubMed / Full text

MIA

• Age, cohort, and period effects on metamemory beliefs. / 12.2019 / PubMed / Full text
• Memory Age-based Stereotype Threat: Role of Locus of Control and Anxiety. / 01-02.2020 / PubMed / Full text
• Role of melanoma inhibitory activity in melanocyte senescence. / 11.2019 / PubMed / Full text
• Refining the metamemory in adulthood questionnaire: a 20-item version of change and capacity designed for research and clinical settings. / 07.2020 / PubMed / Full text
• Maternal Immune Activation Alters Adult Behavior, Gut Microbiome and Juvenile Brain Oscillations in Ferrets. / 09-10.2018 / PubMed / Full text

MITF

• Thymocid , a Standardized Black Cumin ([i]Nigella sativa[/i]) Seed Extract, Modulates Collagen Cross-Linking, Collagenase and Elastase Activities, and Melanogenesis in Murine B16F10 Melanoma Cells. / 19.07.2020 / PubMed / Full text
• HuRdling Senescence: HuR Breaks BRAF-Induced Senescence in Melanocytes and Supports Melanoma Growth. / 21.05.2020 / PubMed / Full text
• Extracellular acidosis triggers a senescence-like phenotype in human melanoma cells. / 01.2020 / PubMed / Full text
• H O promotes the aging process of melanogenesis through modulation of MITF and Nrf2. / 04.2019 / PubMed / Full text
• Deregulated MITF sumoylation: A route to melanoma. / 2017 / PubMed / Full text

MMD

• Association between a Deficit Accumulation Frailty Index and Mobility Outcomes in Older Adults: Secondary Analysis of the Lifestyle Interventions and Independence for Elders (LIFE) Study. / 22.11.2020 / PubMed / Full text
• Impact of Anticholinergic Medication Burden on Mobility and Falls in the Lifestyle Interventions for Elders (LIFE) Study. / 16.09.2020 / PubMed / Full text
• Impact and Lessons From the Lifestyle Interventions and Independence for Elders (LIFE) Clinical Trials of Physical Activity to Prevent Mobility Disability. / 04.2020 / PubMed / Full text
• Lactobacillus rescues postnatal neurobehavioral and microglial dysfunction in a model of maternal microbiome dysbiosis. / 10.2019 / PubMed / Full text
• A Case for Promoting Movement Medicine: Preventing Disability in the LIFE Randomized Controlled Trial. / 04.10.2019 / PubMed / Full text

MTHFR

• One-carbon metabolism supplementation improves outcome after stroke in aged male MTHFR-deficient mice. / 12.2019 / PubMed / Full text
• One-carbon metabolism gene polymorphisms are associated with cognitive trajectory among African-American adults. / 12.2019 / PubMed / Full text
• Dietary Intervention Modifies DNA Methylation Age Assessed by the Epigenetic Clock. / 12.2018 / PubMed / Full text
• Early Manifestations of Brain Aging in Mice Due to Low Dietary Folate and Mild MTHFR Deficiency. / 06.2019 / PubMed / Full text
• Methylenetetrahydrofolate Reductase Deficiency Deregulates Regional Brain Amyloid-β Protein Precursor Expression and Phosphorylation Levels. / 2018 / PubMed / Full text

NANOG

• Restoring extracellular matrix synthesis in senescent stem cells. / 10.2019 / PubMed / Full text
• Maternal ageing impairs mitochondrial DNA kinetics during early embryogenesis in mice. / 08.07.2019 / PubMed / Full text
• Amnion epithelial cell-derived exosomes induce inflammatory changes in uterine cells. / 11.2018 / PubMed / Full text
• NANOG restores the impaired myogenic differentiation potential of skeletal myoblasts after multiple population doublings. / 01.2018 / PubMed / Full text
• Some chemotherapeutics-treated colon cancer cells display a specific phenotype being a combination of stem-like and senescent cell features. / 02.01.2018 / PubMed / Full text

P2RY12

• Potential caveats of putative microglia-specific markers for assessment of age-related cerebrovascular neuroinflammation. / 01.12.2020 / PubMed / Full text
• Microglial changes in the early aging stage in a healthy retina and an experimental glaucoma model. / 2020 / PubMed / Full text
• Patterns of Expression of Purinergic Receptor P2RY12, a Putative Marker for Non-Activated Microglia, in Aged and Alzheimer's Disease Brains. / 20.01.2020 / PubMed / Full text
• Age Influences Microglial Activation After Cuprizone-Induced Demyelination. / 2018 / PubMed / Full text
• Dexamethasone Induces a Specific Form of Ramified Dysfunctional Microglia. / 02.2019 / PubMed / Full text

PER2

• NAD Controls Circadian Reprogramming through PER2 Nuclear Translocation to Counter Aging. / 04.06.2020 / PubMed / Full text
• The protective effect of cycloastragenol on aging mouse circadian rhythmic disorder induced by d-galactose. / 10.2019 / PubMed / Full text
• Investigating circadian clock gene expression in human tendon biopsies from acute exercise and immobilization studies. / 06.2019 / PubMed / Full text
• Is the aging human ovary still ticking?: Expression of clock-genes in luteinized granulosa cells of young and older women. / 21.11.2018 / PubMed / Full text
• Ontogeny of Circadian Rhythms and Synchrony in the Suprachiasmatic Nucleus. / 07.02.2018 / PubMed / Full text

PIK3CA

• Myocyte enhancer factor 2A delays vascular endothelial cell senescence by activating the PI3K/p-Akt/SIRT1 pathway. / 10.06.2019 / PubMed / Full text
• Oncogenic mutations in histologically normal endometrium: the new normal? / 10.2019 / PubMed / Full text
• A clinical trial of somatic and germline analyses for healthy longevity in a postoperative cancer patient. / 09.2019 / PubMed / Full text
• Membrane metallo-endopeptidase mediates cellular senescence induced by oncogenic PIK3CA accompanied with pro-tumorigenic secretome. / 01.08.2019 / PubMed / Full text
• Therapeutic and preventive effects of exercise on cardiometabolic parameters in aging and obese rats. / 02.2019 / PubMed / Full text

RIPK3

• Metformin mediates cardioprotection against aging-induced ischemic necroptosis. / 02.2020 / PubMed / Full text
• A small molecule Nec-1 directly induces amyloid clearance in the brains of aged APP/PS1 mice. / 12.03.2019 / PubMed / Full text
• RIP kinases as modulators of inflammation and immunity. / 09.2018 / PubMed / Full text
• Necroptosis increases with age and is reduced by dietary restriction. / 08.2018 / PubMed / Full text
• RIPK1-RIPK3-MLKL-dependent necrosis promotes the aging of mouse male reproductive system. / 15.08.2017 / PubMed / Full text

ROCK2

• Physical exercise increases ROCK activity in the skeletal muscle of middle-aged rats. / 03.2020 / PubMed / Full text
• Disruption of both ROCK1 and ROCK2 genes in cardiomyocytes promotes autophagy and reduces cardiac fibrosis during aging. / 06.2019 / PubMed / Full text
• Role of age, Rho-kinase 2 expression, and G protein-mediated signaling in the myogenic response in mouse small mesenteric arteries. / 09.2018 / PubMed / Full text
• Vascular Smooth Muscle Contractile Function Declines With Age in Skeletal Muscle Feed Arteries. / 2018 / PubMed / Full text
• Changes in Cerebral Arteries and Parenchymal Arterioles With Aging: Role of Rho Kinase 2 and Impact of Genetic Background. / 05.2018 / PubMed / Full text

SAG

• WRKY42 transcription factor positively regulates leaf senescence through modulating SA and ROS synthesis in Arabidopsis thaliana. / 09.2020 / PubMed / Full text
• Neurogenesis in the inner ear: the zebrafish statoacoustic ganglion provides new neurons from a Neurod/Nestin-positive progenitor pool well into adulthood. / 10.04.2020 / PubMed / Full text
• Effects of natural dietary supplementation with Macleaya cordata extract containing sanguinarine on growth performance and gut health of early-weaned piglets. / 12.2018 / PubMed / Full text
• Genetic redundancy of senescence-associated transcription factors in Arabidopsis. / 12.02.2018 / PubMed / Full text
• Proteomic Investigations of Proteases Involved in Cotyledon Senescence: A Model to Explore the Genotypic Variability of Proteolysis Machinery Associated with Nitrogen Remobilization Efficiency during the Leaf Senescence of Oilseed Rape. / 02.11.2017 / PubMed / Full text

SMAD3

• Sirtuin 6 deficiency transcriptionally up-regulates TGF-β signaling and induces fibrosis in mice. / 10.01.2020 / PubMed / Full text
• Restoring extracellular matrix synthesis in senescent stem cells. / 10.2019 / PubMed / Full text
• Chromatin remodeling factor BAZ1A regulates cellular senescence in both cancer and normal cells. / 15.07.2019 / PubMed / Full text
• Histopathological and molecular analysis of idiopathic pulmonary fibrosis lungs from patients treated with pirfenidone or nintedanib. / 01.2019 / PubMed / Full text
• Beta-Catenin and SMAD3 Are Associated with Skeletal Muscle Aging in the Taurine Transpoeter Knockout Mouse. / 2017 / PubMed / Full text

SNCA

• Behavioural and dopaminergic changes in double mutated human A30P*A53T alpha-synuclein transgenic mouse model of Parkinson´s disease. / 22.11.2019 / PubMed / Full text
• Reducing INS-IGF1 signaling protects against non-cell autonomous vesicle rupture caused by SNCA spreading. / 05.2020 / PubMed / Full text
• SerThr-PhosphoProteome of Brain from Aged PINK1-KO+A53T-SNCA Mice Reveals pT1928-MAP1B and pS3781-ANK2 Deficits, as Hub between Autophagy and Synapse Changes. / 04.07.2019 / PubMed / Full text
• Age-dependent accumulation of oligomeric SNCA/α-synuclein from impaired degradation in mutant LRRK2 knockin mouse model of Parkinson disease: role for therapeutic activation of chaperone-mediated autophagy (CMA). / 02.2020 / PubMed / Full text
• Caloric restriction rescues yeast cells from alpha-synuclein toxicity through autophagic control of proteostasis. / 07.12.2018 / PubMed / Full text

SON

• Absence of axonal sprouting following unilateral lesion in 125-day-old rat supraoptic nucleus may be due to age-dependent decrease in protein levels of ciliary neurotrophic factor receptor alpha. / 01.10.2019 / PubMed / Full text
• Neural Mechanisms Involved in the Noxious Physical Stress-Induced Inhibition of Ovarian Estradiol Secretion. / 06.2019 / PubMed / Full text
• Aging affects isoproterenol-induced water drinking, astrocyte density, and central neuronal activation in female Brown Norway rats. / 01.08.2018 / PubMed / Full text
• The effects of aging on biosynthetic processes in the rat hypothalamic osmoregulatory neuroendocrine system. / 05.2018 / PubMed / Full text
• Increased oxytocin-monomeric red fluorescent protein 1 fluorescent intensity with urocortin-like immunoreactivity in the hypothalamo-neurohypophysial system of aged transgenic rats. / 03.2018 / PubMed / Full text

SRF

• Changes in snail and SRF expression in the kidneys of diabetic rats during ageing. / 01.2020 / PubMed / Full text
• Mechanosensitive transcriptional coactivators MRTF-A and YAP/TAZ regulate nucleus pulposus cell phenotype through cell shape. / 12.2019 / PubMed / Full text
• Resource recovery potentials by landfill mining and reclamation in South Korea. / 15.07.2019 / PubMed / Full text
• Pre-existing fibroblasts of epicardial origin are the primary source of pathological fibrosis in cardiac ischemia and aging. / 04.2019 / PubMed / Full text
• Targeting MRTF/SRF in CAP2-dependent dilated cardiomyopathy delays disease onset. / 21.03.2019 / PubMed / Full text

TAZ

• Transcriptional Coactivator TAZ Negatively Regulates Tumor Suppressor p53 Activity and Cellular Senescence. / 09.01.2020 / PubMed / Full text
• Downregulation of miR-125b promotes resistance of glioma cells to TRAIL through overexpression of Tafazzin which is a mitochondrial protein. / 05.05.2019 / PubMed / Full text
• Dysregulation of the Hippo pathway signaling in aging and cancer. / 05.2019 / PubMed / Full text
• Long noncoding RNA Bmncr regulates mesenchymal stem cell fate during skeletal aging. / 03.12.2018 / PubMed / Full text
• PGC-1α Controls Skeletal Stem Cell Fate and Bone-Fat Balance in Osteoporosis and Skeletal Aging by Inducing TAZ. / 02.08.2018 / PubMed / Full text

TRPM2

• Paraquat as an Environmental Risk Factor in Parkinson's Disease Accelerates Age-Related Degeneration Via Rapid Influx of Extracellular Zn into Nigral Dopaminergic Neurons. / 11.2019 / PubMed / Full text
• Pathophysiological Role of TRPM2 in Age-Related Cognitive Impairment in Mice. / 01.06.2019 / PubMed / Full text
• The TRPM2 channel nexus from oxidative damage to Alzheimer's pathologies: An emerging novel intervention target for age-related dementia. / 11.2018 / PubMed / Full text
• TRPM2 in the Brain: Role in Health and Disease. / 22.07.2018 / PubMed / Full text
• mRNA expression of transient receptor potential melastatin (TRPM) channels 2 and 7 in perinatal brain development. / 10.2018 / PubMed / Full text

TTR

• Cellular secretion and cytotoxicity of transthyretin mutant proteins underlie late-onset amyloidosis and neurodegeneration. / 04.2020 / PubMed / Full text
• Development of transgenic Caenorhabditis elegans expressing human transthyretin as a model for drug screening. / 14.12.2018 / PubMed / Full text
• Age-dependent cognitive dysfunction in untreated hereditary transthyretin amyloidosis. / 02.2018 / PubMed / Full text
• The delaying effect of alpha-glycerophosphocholine on senescence, transthyretin deposition, and osteoarthritis in senescence-accelerated mouse prone 8 mice. / 04.2018 / PubMed / Full text
• Transthyretin deposition promotes progression of osteoarthritis. / 12.2017 / PubMed / Full text

ZMPSTE24

• Bone marrow-derived mesenchymal stem cells in three-dimensional co-culture attenuate degeneration of nucleus pulposus cells. / 30.10.2019 / PubMed / Full text
• A humanized yeast system to analyze cleavage of prelamin A by ZMPSTE24. / 15.03.2019 / PubMed / Full text
• Proteomic Evidence of Biological Aging in a Child with a Compound Heterozygous ZMPSTE24 Mutation. / 03.2019 / PubMed / Full text
• Abnormal nuclear morphology is independent of longevity in a zmpste24-deficient fish model of Hutchinson-Gilford progeria syndrome (HGPS). / 07.2018 / PubMed / Full text
• Mandibuloacral dysplasia: A premature ageing disease with aspects of physiological ageing. / 03.2018 / PubMed / Full text

ADA

• Adenosine Metabolism in the Cerebral Cortex from Several Mice Models during Aging. / 02.10.2020 / PubMed / Full text
• Risk factors for diabetic kidney disease in adults with longstanding type 1 diabetes: results from the Canadian Study of Longevity in Diabetes. / 11.2019 / PubMed / Full text
• Ideglira is Associated With Improved Short-Term Clinical Outcomes and Cost Savings Compared with Insulin Glargine U100 Plus Insulin Aspart in the U.S. / 09.2018 / PubMed / Full text
• Mismatch between ADA and AGS recommendations for glycated hemoglobin targets for older adults. / 04.2018 / PubMed / Full text

AHR

• Indoles from the commensal microbiota act via the AHR and IL-10 to tune the cellular composition of the colonic epithelium during aging. / 01.09.2020 / PubMed / Full text
• Role of the Aryl Hydrocarbon Receptor in Environmentally Induced Skin Aging and Skin Carcinogenesis. / 28.11.2019 / PubMed / Full text
• Loss of Neurogenesis in Aging Hydra. / 05.2019 / PubMed / Full text
• Environmental cues received during development shape dendritic cell responses later in life. / 2018 / PubMed / Full text

BPIFB4

• New Insights for BPIFB4 in Cardiovascular Therapy. / 28.09.2020 / PubMed / Full text
• LAV-BPIFB4 associates with reduced frailty in humans and its transfer prevents frailty progression in old mice. / 28.08.2019 / PubMed / Full text
• Longevity-Associated Variant of BPIFB4 Mitigates Monocyte-Mediated Acquired Immune Response. / 13.11.2019 / PubMed / Full text
• A Model of Evolutionary Selection: The Cardiovascular Protective Function of the Longevity Associated Variant of BPIFB4. / 19.10.2018 / PubMed / Full text

C6

• Evolution of the Aroma of Treixadura Wines during Bottle Aging. / 08.10.2020 / PubMed / Full text
• D-galactose induces senescence of glioblastoma cells through YAP-CDK6 pathway. / 29.09.2020 / PubMed / Full text
• Alcohol Extracts From [i]Ganoderma lucidum[/i] Delay the Progress of Alzheimer's Disease by Regulating DNA Methylation in Rodents. / 2019 / PubMed / Full text
• Age and Sex-Associated Changes of Complement Activity and Complement Levels in a Healthy Caucasian Population. / 2018 / PubMed / Full text

CD33

• Maximum reproductive lifespan correlates with CD33rSIGLEC gene number: Implications for NADPH oxidase-derived reactive oxygen species in aging. / 02.2020 / PubMed / Full text
• New genetic players in late-onset Alzheimer's disease: Findings of genome-wide association studies. / 08.2018 / PubMed / Full text
• Chromogenic Multiplex Immunohistochemistry Reveals Modulation of the Immune Microenvironment Associated with Survival in Elderly Patients with Lung Adenocarcinoma. / 13.09.2018 / PubMed / Full text
• Recent studies on cellular and molecular mechanisms in Alzheimer's disease: focus on epigenetic factors and histone deacetylase. / 28.03.2018 / PubMed / Full text

CRH

• Roles of peptides and steroids in sleep disorders. / 09.2006 / PubMed / Full text
• Novel molecular mechanisms for the adaptogenic effects of herbal extracts on isolated brain cells using systems biology. / 15.11.2018 / PubMed / Full text
• Caenorhabditis elegans respond to high-glucose diets through a network of stress-responsive transcription factors. / 2018 / PubMed / Full text
• Genome-wide association study and annotating candidate gene networks affecting age at first calving in Nellore cattle. / 12.2017 / PubMed / Full text

CXCL8

• Cerebrovascular Senescence Is Associated With Tau Pathology in Alzheimer's Disease. / 2020 / PubMed / Full text
• Age-related pro-inflammatory and pro-angiogenic changes in human aqueous humor. / 2018 / PubMed / Full text
• Immune senescence and biomarkers profile of Bambuí aged population-based cohort. / 03.2018 / PubMed / Full text
• Predictive value of multiple cytokines and chemokines for mortality in an admixed population: 15-year follow-up of the Bambui-Epigen (Brazil) cohort study of aging. / 11.2017 / PubMed / Full text

CXCR3

• Senescent hepatocytes enhance natural killer cell activity via the CXCL-10/CXCR3 axis. / 11.2019 / PubMed / Full text
• Age-associated antigen-presenting cell alterations promote dry-eye inducing Th1 cells. / 07.2019 / PubMed / Full text
• CXCR3 CD8 T cells with naïve phenotype and high capacity for IFN-γ production are generated during homeostatic T-cell proliferation. / 10.2018 / PubMed / Full text
• The parasite-derived rOv-ASP-1 is an effective antigen-sparing CD4 T cell-dependent adjuvant for the trivalent inactivated influenza vaccine, and functions in the absence of MyD88 pathway. / 14.06.2018 / PubMed / Full text

CYP2C19

• Physiologically Based Pharmacokinetic Approach Can Successfully Predict Pharmacokinetics of Citalopram in Different Patient Populations. / 04.2020 / PubMed / Full text
• Longitudinal exposure of English primary care patients to pharmacogenomic drugs: An analysis to inform design of pre-emptive pharmacogenomic testing. / 12.2019 / PubMed / Full text
• The safety, tolerability and pharmacokinetics of BI 409306, a novel and potent PDE9 inhibitor: Overview of three Phase I randomised trials in healthy volunteers. / 05.2018 / PubMed / Full text
• Pediatric Cytochrome P450 Activity Alterations in Nonalcoholic Steatohepatitis. / 12.2017 / PubMed / Full text

CYP2E1

• DNA methylation and histone acetylation changes to cytochrome P450 2E1 regulation in normal aging and impact on rates of drug metabolism in the liver. / 06.2020 / PubMed / Full text
• 2, 3, 4', 5-tetrahydroxystilbene-2-0-β-d Glycoside Attenuates Age- and Diet-Associated Non-Alcoholic Steatohepatitis and Atherosclerosis in LDL Receptor Knockout Mice and Its Possible Mechanisms. / 01.04.2019 / PubMed / Full text
• Neuroprotective Effect of Dioscin on the Aging Brain. / 30.03.2019 / PubMed / Full text
• Cytochrome P450-2E1 is involved in aging-related kidney damage in mice through increased nitroxidative stress. / 11.2017 / PubMed / Full text

DCC

• X Chromosome Domain Architecture Regulates Caenorhabditis elegans Lifespan but Not Dosage Compensation. / 21.10.2019 / PubMed / Full text
• Dynamic functional connectivity analysis of functional MRI based on copula time-varying correlation. / 15.07.2019 / PubMed / Full text
• Comprehensive outpatient rehabilitation increases the ability of people over 60 to live independently. / 20.12.2018 / PubMed / Full text
• Mesocorticolimbic Connectivity and Volumetric Alterations in [i]DCC[/i] Mutation Carriers. / 16.05.2018 / PubMed / Full text

EFS

• The aging bladder phenotype is not the direct consequence of bladder aging. / 11.2019 / PubMed / Full text
• Autonomic dysregulation at multiple sites is implicated in age-associated underactive bladder in female mice. / 06.2019 / PubMed / Full text
• Does the empty follicle syndrome occur in cases of low number of maturing follicles in assisted reproduction? / 04.2019 / PubMed / Full text
• Changes in the interstitial cells of Cajal and neuronal nitric oxide synthase positive neuronal cells with aging in the esophagus of F344 rats. / 2017 / PubMed / Full text

ERAS

• Enhanced Recovery After Surgery: Are the Principles Applicable to Adult and Geriatric Acute Care and Trauma Surgery? / 03.2019 / PubMed / Full text
• Prospective application of an implementation framework to improve postoperative nutrition care processes: Evaluation of a mixed methods implementation study. / 09.2018 / PubMed / Full text
• Enhanced Recovery After Surgery (ERAS) - The Evidence in Geriatric Emergency Surgery: A Systematic Review. / Sept-10.2017 / PubMed / Full text
• Multimodal Rehabilitation in Geriatric Emergency Surgery. / Sept-10.2017 / PubMed / Full text

FGA

• Goal Pursuit, Goal Adjustment, and Pain in Middle-Aged Adults Aging With Physical Disability. / 12.2019 / PubMed / Full text
• Tenacious Goal Pursuit, Flexible Goal Adjustment, and Life Satisfaction Among Chinese Older Adult Couples. / 01.2020 / PubMed / Full text
• Association of tenacious goal pursuit and flexible goal adjustment with out-of-home mobility among community-dwelling older people. / 09.2019 / PubMed / Full text
• Assimilative and accommodative coping in older adults with and without sensory impairment: four-year change and prospective relations with affective well-being. / 09.2019 / PubMed / Full text

FGF19

• Bile acid receptor agonists in primary biliary cholangitis: Regulation of the cholangiocyte secretome and downstream T cell differentiation. / 05.2019 / PubMed / Full text
• Kotho and aging. / 09.2016 / PubMed
• The Klotho proteins in health and disease. / 01.2019 / PubMed / Full text
• Peroxisomal Acyl-CoA Oxidase Type 1: Anti-Inflammatory and Anti-Aging Properties with a Special Emphasis on Studies with LPS and Argan Oil as a Model Transposable to Aging. / 2018 / PubMed / Full text

FGF2

• The influence of fibroblast growth factor 2 on the senescence of human adipose-derived mesenchymal stem cells during long-term culture. / 04.2020 / PubMed / Full text
• Adipose-Derived Stem/Stromal Cells Recapitulate Aging Biomarkers and Show Reduced Stem Cell Plasticity Affecting Their Adipogenic Differentiation Capacity. / 08.2019 / PubMed / Full text
• Evaluation of human mesenchymal stem cell senescence, differentiation and secretion behavior cultured on polycarbonate cell culture inserts. / 2018 / PubMed / Full text
• Young bone marrow Sca-1 cells protect aged retina from ischaemia-reperfusion injury through activation of FGF2. / 12.2018 / PubMed / Full text

FGR

• Aurora kinase mRNA expression is reduced with increasing gestational age and in severe early onset fetal growth restriction. / 06.2020 / PubMed / Full text
• Premature Vascular Aging in Guinea Pigs Affected by Fetal Growth Restriction. / 15.07.2019 / PubMed / Full text
• Premature placental aging in term small-for-gestational-age and growth-restricted fetuses. / 05.2019 / PubMed / Full text
• The effect of fertility treatment on adverse perinatal outcomes in women aged at least 40 years. / 01.2018 / PubMed / Full text

FOXM1

• Sirtuin 6 deficiency induces endothelial cell senescence via downregulation of forkhead box M1 expression. / 10.11.2020 / PubMed / Full text
• Upregulation of FOXM1 leads to diminished drug sensitivity in myeloma. / 21.11.2018 / PubMed / Full text
• Preclinical characterization of abemaciclib in hormone receptor positive breast cancer. / 19.09.2017 / PubMed / Full text
• Age-dependent human β cell proliferation induced by glucagon-like peptide 1 and calcineurin signaling. / 02.10.2017 / PubMed / Full text

FOXO6

• Novel molecular mechanisms for the adaptogenic effects of herbal extracts on isolated brain cells using systems biology. / 15.11.2018 / PubMed / Full text
• Introduction to FOXO Biology. / 2019 / PubMed / Full text
• FOXO in Neural Cells and Diseases of the Nervous System. / 2018 / PubMed / Full text
• FOXO Transcriptional Factors and Long-Term Living. / 2017 / PubMed / Full text

GAA

• Mitochondrial damage and senescence phenotype of cells derived from a novel frataxin G127V point mutation mouse model of Friedreich's ataxia. / 27.07.2020 / PubMed / Full text
• Age-Related Changes in Serum Guanidinoacetic Acid in Women. / 30.12.2019 / PubMed / Full text
• ALKB-8, a 2-Oxoglutarate-Dependent Dioxygenase and S-Adenosine Methionine-Dependent Methyltransferase Modulates Metabolic Events Linked to Lysosome-Related Organelles and Aging in C. elegans. / 2018 / PubMed
• SIRT6 histone deacetylase functions as a potential oncogene in human melanoma. / 09.2017 / PubMed / Full text

GAP43

• HDAC inhibition leads to age-dependent opposite regenerative effect upon PTEN deletion in rubrospinal axons after SCI. / 06.2020 / PubMed / Full text
• Sonic hedgehog regulation of cavernous nerve regeneration and neurite formation in aged pelvic plexus. / 02.2019 / PubMed / Full text
• Differential expression of synaptic and interneuron genes in the aging human prefrontal cortex. / 10.2018 / PubMed / Full text
• Schwann Cell Phenotype Changes in Aging Human Dental Pulp. / 03.2018 / PubMed / Full text

GAPDH

• Age-dependent accumulation of oligomeric SNCA/α-synuclein from impaired degradation in mutant LRRK2 knockin mouse model of Parkinson disease: role for therapeutic activation of chaperone-mediated autophagy (CMA). / 02.2020 / PubMed / Full text
• Selection of a Real-Time PCR Housekeeping Gene Panel in Human Endothelial Colony Forming Cells for Cellular Senescence Studies. / 2019 / PubMed / Full text
• Age-related changes in mRNA expression of selected surface receptors in lymphocytes of dairy calves. / 03.2018 / PubMed / Full text
• Changes in contractile and metabolic parameters of skeletal muscle as rats age from 3 to 12 months. / 12.2017 / PubMed / Full text

GCLM

• Silencing Bach1 alters aging-related changes in the expression of Nrf2-regulated genes in primary human bronchial epithelial cells. / 15.09.2019 / PubMed / Full text
• Ontogeny and aging of Nrf2 pathway genes in livers of rats. / 15.06.2018 / PubMed / Full text
• Sulfur amino acid restriction-induced changes in redox-sensitive proteins are associated with slow protein synthesis rates. / 04.2018 / PubMed / Full text
• Aging-related decline in the induction of Nrf2-regulated antioxidant genes in human bronchial epithelial cells. / 04.2018 / PubMed / Full text

GGCT

• Blockade of γ-Glutamylcyclotransferase Enhances Docetaxel Growth Inhibition of Prostate Cancer Cells. / 09.2019 / PubMed / Full text
• Mechanisms of Tumor Growth Inhibition by Depletion of γ-Glutamylcyclotransferase (GGCT): A Novel Molecular Target for Anticancer Therapy. / 14.07.2018 / PubMed / Full text
• Depletion of gamma-glutamylcyclotransferase in cancer cells induces autophagy followed by cellular senescence. / 2018 / PubMed / Full text
• Prohibitin-2 is a novel regulator of p21 induced by depletion of γ-glutamylcyclotransferase. / 29.01.2018 / PubMed / Full text

GRK2

• G protein-coupled receptor kinase 2 modifies the ability of Caenorhabditis elegans to survive oxidative stress. / 16.10.2020 / PubMed / Full text
• G protein coupled receptor kinases modulate Caenorhabditis elegans reactions to heat stresses. / 01.10.2020 / PubMed / Full text
• Loss of dynamic regulation of G protein-coupled receptor kinase 2 by nitric oxide leads to cardiovascular dysfunction with aging. / 01.05.2020 / PubMed / Full text
• Senescent Cells Differentially Translate Senescence-Related mRNAs Via Ribosome Heterogeneity. / 18.06.2019 / PubMed / Full text

HMGB2

• Loss of Endogenous HMGB2 Promotes Cardiac Dysfunction and Pressure Overload-Induced Heart Failure in Mice. / 25.01.2019 / PubMed / Full text
• HMGB2 Loss upon Senescence Entry Disrupts Genomic Organization and Induces CTCF Clustering across Cell Types. / 17.05.2018 / PubMed / Full text
• Correlations between age, functional status, and the senescence-associated proteins HMGB2 and p16 . / 04.2018 / PubMed / Full text
• Transcriptional Repression of High-Mobility Group Box 2 by p21 in Radiation-Induced Senescence. / 30.04.2018 / PubMed / Full text

HMGCR

• Cholesterol Homeostasis: An In Silico Investigation into How Aging Disrupts Its Key Hepatic Regulatory Mechanisms. / 30.09.2020 / PubMed / Full text
• Artesunate inhibits the mevalonate pathway and promotes glioma cell senescence. / 01.2020 / PubMed / Full text
• Reactive oxygen species-induced changes in glucose and lipid metabolism contribute to the accumulation of cholesterol in the liver during aging. / 04.2019 / PubMed / Full text
• The Age-dependent Elevation of miR-335-3p Leads to Reduced Cholesterol and Impaired Memory in Brain. / 15.10.2018 / PubMed / Full text

IGFBP2

• Intracellular Insulin-like growth factor binding protein 2 (IGFBP2) contributes to the senescence of keratinocytes in psoriasis by stabilizing cytoplasmic p21. / 17.04.2020 / PubMed / Full text
• TMT-Based Quantitative Proteomic Analysis Reveals Proteomic Changes Involved in Longevity. / 07.2019 / PubMed / Full text
• IGFBP-2 and aging: a 20-year longitudinal study on IGFBP-2, IGF-I, BMI, insulin sensitivity and mortality in an aging population. / 01.02.2019 / PubMed / Full text
• Proteomic profiling of follicle fluids after superstimulation in one-month-old lambs. / 02.2018 / PubMed / Full text

IL1B

• Aged marrow macrophages expand platelet-biased hematopoietic stem cells via Interleukin1B. / 18.04.2019 / PubMed / Full text
• MEF2A alters the proliferation, inflammation-related gene expression profiles and its silencing induces cellular senescence in human coronary endothelial cells. / 18.03.2019 / PubMed / Full text
• Measuring the Inflammasome in Oncogene-Induced Senescence. / 2019 / PubMed / Full text
• Lower levels of interleukin-1β gene expression are associated with impaired Langerhans' cell migration in aged human skin. / 01.2018 / PubMed / Full text

IMPACT

• Load-dependent modulation of alpha oscillations during working memory encoding and retention in young and older adults. / 03.11.2020 / PubMed / Full text
• Using Video Telehealth to Deliver Patient-Centered Collaborative Care: The G-IMPACT Pilot. / 31.03.2020 / PubMed / Full text
• AGING, HEART RATE VARIABILITY AND METABOLIC IMPACT OF OBESITY. / 09.2019 / PubMed / Full text
• Endophytic Bacillus strains isolated from alfalfa (Medicago sativa L.) seeds: enhancing the lifespan of Caenorhabditis elegans. / 03.2019 / PubMed / Full text

IRS2

• Effects of Heshouwuyin on gene expression of the insulin/IGF signalling pathway in rat testis and spermatogenic cells. / 12.2020 / PubMed / Full text
• Involvement of insulin receptor substrates in cognitive impairment and Alzheimer's disease. / 08.2019 / PubMed / Full text
• The senescent status of endothelial cells affects proliferation, inflammatory profile and SOX2 expression in bone marrow-derived mesenchymal stem cells. / 06.2019 / PubMed / Full text
• Therapeutic and preventive effects of exercise on cardiometabolic parameters in aging and obese rats. / 02.2019 / PubMed / Full text

JAK1

• Irradiation-induced senescence of bone marrow mesenchymal stem cells aggravates osteogenic differentiation dysfunction via paracrine signaling. / 01.05.2020 / PubMed / Full text
• The Upregulation of Toll-Like Receptor 3 via Autocrine IFN-β Signaling Drives the Senescence of Human Umbilical Cord Blood-Derived Mesenchymal Stem Cells Through JAK1. / 2019 / PubMed / Full text
• Influence of age and renal impairment on the steady state pharmacokinetics of filgotinib, a selective JAK1 inhibitor. / 12.2018 / PubMed / Full text
• Immunologic effects of chronic administration of tofacitinib, a Janus kinase inhibitor, in cynomolgus monkeys and rats - Comparison of juvenile and adult responses. / 04.2018 / PubMed / Full text

JUN

• Age-Onset Phosphorylation of a Minor Actin Variant Promotes Intestinal Barrier Dysfunction. / 02.12.2019 / PubMed / Full text
• 1,3,5,8-Tetrahydroxy-9H-xanthen-9-one exerts its antiageing effect through the regulation of stress-response genes and the MAPK signaling pathway. / 09.2019 / PubMed / Full text
• Urolithin A Inhibits the Catabolic Effect of TNFα on Nucleus Pulposus Cell and Alleviates Intervertebral Disc Degeneration [i]in vivo[/i]. / 2018 / PubMed / Full text
• Schwann cell O-GlcNAcylation promotes peripheral nerve remyelination via attenuation of the AP-1 transcription factor JUN. / 31.07.2018 / PubMed / Full text

KLF14

• DNA methylation of the ELOVL2, FHL2, KLF14, C1orf132/MIR29B2C, and TRIM59 genes for age prediction from blood, saliva, and buccal swab samples. / 01.2019 / PubMed / Full text
• Proof of concept study of age-dependent DNA methylation markers across different tissues by massive parallel sequencing. / 09.2018 / PubMed / Full text
• Chronological age prediction based on DNA methylation: Massive parallel sequencing and random forest regression. / 11.2017 / PubMed / Full text
• Detection and evaluation of DNA methylation markers found at SCGN and KLF14 loci to estimate human age. / 11.2017 / PubMed / Full text

LEP

• Age- and Sex-Specific Changes in Lower-Limb Muscle Power Throughout the Lifespan. / 18.06.2020 / PubMed / Full text
• The Copenhagen Sarcopenia Study: lean mass, strength, power, and physical function in a Danish cohort aged 20-93 years. / 12.2019 / PubMed / Full text
• Caregiving for Older Adults with Limited English Proficiency: Transitioning from Hospital to Home. / 09.2019 / PubMed / Full text
• Effects of macronutrient intake on the lifespan and fecundity of the marula fruit fly, [i]Ceratitis cosyra[/i] (Tephritidae): Extreme lifespan in a host specialist. / 11.2017 / PubMed / Full text

LTA

• Lipoteichoic acid from the cell wall of a heat killed Lactobacillus paracasei D3-5 ameliorates aging-related leaky gut, inflammation and improves physical and cognitive functions: from C. elegans to mice. / 02.2020 / PubMed / Full text
• The change of pain classes over time: a latent transition analysis. / 02.2020 / PubMed / Full text
• Leisure time activities as mediating variables in functional disability progression: An application of parallel latent growth curve modeling. / 2018 / PubMed / Full text
• The Neighborhood Built Environment and Cognitive Function of Older Persons: Results from the Singapore Longitudinal Ageing Study. / 2018 / PubMed / Full text

MAG

• Exploration of life satisfaction of Korean people with sensory impairments across the lifespan. / 10.2020 / PubMed / Full text
• Omega-3 Monoacylglyceride Effects on Longevity, Mitochondrial Metabolism and Oxidative Stress: Insights from [i]Drosophila melanogaster[/i]. / 16.11.2018 / PubMed / Full text
• Glial Sulfatides and Neuronal Complex Gangliosides Are Functionally Interdependent in Maintaining Myelinating Axon Integrity. / 02.01.2019 / PubMed / Full text
• Gray Matter Volume and Cognitive Performance During Normal Aging. A Voxel-Based Morphometry Study. / 2018 / PubMed / Full text

MCU

• A rare case of Epstein-Barr virus-positive mucocutaneous ulcer that developed into an intestinal obstruction: a case report. / 13.01.2020 / PubMed / Full text
• Inhibition of Mitochondrial Calcium Overload by SIRT3 Prevents Obesity- or Age-Related Whitening of Brown Adipose Tissue. / 02.2020 / PubMed / Full text
• Cytosolic and mitochondrial Ca concentrations in primary hepatocytes change with ageing and in consequence of an mtDNA mutation. / 09.2019 / PubMed / Full text
• The nuclear receptor RXRA controls cellular senescence by regulating calcium signaling. / 12.2018 / PubMed / Full text

MME

• Geriatric Opioid Harm Reduction: Interprofessional Student Learning Outcomes. / 01-12.2020 / PubMed / Full text
• Effectiveness of local anesthetic injection in geriatric patients following operative management of proximal and diaphyseal femur fracture. / 11.2019 / PubMed / Full text
• Membrane metallo-endopeptidase mediates cellular senescence induced by oncogenic PIK3CA accompanied with pro-tumorigenic secretome. / 01.08.2019 / PubMed / Full text
• Medial meniscus extrusion increases with age and BMI and is depending on different loading conditions. / 08.2018 / PubMed / Full text

MOS

• Effect of mannan oligosaccharides on the microbiota and productivity parameters of Litopenaeus vannamei shrimp under intensive cultivation in Ecuador. / 17.02.2020 / PubMed / Full text
• Predictors of health-related quality of life among older adults living with HIV in Thailand: results from the baseline and follow-up surveys. / 23.12.2019 / PubMed / Full text
• Comparison of health-related quality of life between the Han and Yi ethnicity elderly in the Yi autonomous areas of Yunnan Province. / 25.11.2019 / PubMed / Full text
• Mannan oligosaccharide increases the growth performance, immunity and resistance capability against Vibro Parahemolyticus in juvenile abalone Haliotis discus hannai Ino. / 11.2019 / PubMed / Full text

MRE11

• Chromosomal alterations among age-related haematopoietic clones in Japan. / 08.2020 / PubMed / Full text
• Mechanistic link between DNA damage sensing, repairing and signaling factors and immune signaling. / 2019 / PubMed / Full text
• The activated DNA double-strand break repair pathway in cumulus cells from aging patients may be used as a convincing predictor of poor outcomes after in vitro fertilization-embryo transfer treatment. / 2018 / PubMed / Full text
• Transactivation domain of p53 regulates DNA repair and integrity in human iPS cells. / 01.09.2018 / PubMed / Full text

NEDD8

• Targeting Protein Neddylation for Cancer Therapy. / 2020 / PubMed / Full text
• Effective targeting of the ubiquitin-like modifier NEDD8 for lung adenocarcinoma treatment. / 08.2020 / PubMed / Full text
• Pevonedistat targeted therapy inhibits canine melanoma cell growth through induction of DNA re-replication and senescence. / 09.2020 / PubMed / Full text
• Protein neddylation and its alterations in human cancers for targeted therapy. / 04.2018 / PubMed / Full text

NNT

• Yoga, Health-Related Quality of Life and Mental Well-Being: A Re-analysis of a Meta-analysis Using the Quality Effects Model. / 16.09.2020 / PubMed / Full text
• Statins After Myocardial Infarction in the Oldest: A Cohort Study in the Clinical Practice Research Datalink Database. / 02.2020 / PubMed / Full text
• Years of Life Lost for Older Patients After Colorectal Cancer Diagnosis. / 08.2019 / PubMed / Full text
• Nicotinamide nucleotide transhydrogenase is required for brain mitochondrial redox balance under hampered energy substrate metabolism and high-fat diet. / 12.2018 / PubMed / Full text

NOTCH1

• [How Does Aging Contribute to Cancer?] / 09.2020 / PubMed
• H19 is not hypomethylated or upregulated with age or sex in the aortic valves of mice. / 10.2019 / PubMed / Full text
• Age-related remodelling of oesophageal epithelia by mutated cancer drivers. / 01.2019 / PubMed / Full text
• Dynamic regulation of NOTCH1 activation and Notch ligand expression in human thymus development. / 13.08.2018 / PubMed / Full text

NPC1

• Evaluation of age of death in Niemann-Pick disease, type C: Utility of disease support group websites to understand natural history. / 04.2019 / PubMed / Full text
• AAV9 intracerebroventricular gene therapy improves lifespan, locomotor function and pathology in a mouse model of Niemann-Pick type C1 disease. / 01.09.2018 / PubMed / Full text
• SIRT6 histone deacetylase functions as a potential oncogene in human melanoma. / 09.2017 / PubMed / Full text
• The adenosine A receptor agonist T1-11 ameliorates neurovisceral symptoms and extends the lifespan of a mouse model of Niemann-Pick type C disease. / 02.2018 / PubMed / Full text

NPS

• Cortical β-amyloid burden, neuropsychiatric symptoms, and cognitive status: the Mayo Clinic Study of Aging. / 28.03.2019 / PubMed / Full text
• Mild Behavioral Impairment as a Marker of Cognitive Decline in Cognitively Normal Older Adults. / 08.2019 / PubMed / Full text
• The course of neuropsychiatric symptoms in patients with dementia in primary care. / 31.07.2019 / PubMed / Full text
• Serum calcium levels and neuropsychological performance in depression and matched healthy controls: Reversal of correlation a marker of the aging cognitive clock? / 05.2018 / PubMed / Full text

NRAS

• Senescent cholangiocytes release extracellular vesicles that alter target cell phenotype via the epidermal growth factor receptor. / 10.2020 / PubMed / Full text
• STAT3 Relays a Differential Response to Melanoma-Associated [i]NRAS[/i] Mutations. / 02.01.2020 / PubMed / Full text
• Cooperation of Dnmt3a R878H with Nras G12D promotes leukemogenesis in knock-in mice: a pilot study. / 08.11.2019 / PubMed / Full text
• Sequential acquisition of mutations in myelodysplastic syndromes. / 2017 / PubMed / Full text

OTC

• Age and growth of stocked juvenile Shoal Bass in a tailwater: Environmental variation and accuracy of daily age estimates. / 2019 / PubMed / Full text
• Comprehensive characterization of ureagenesis in the spf mouse, a model of human ornithine transcarbamylase deficiency, reveals age-dependency of ammonia detoxification. / 11.2019 / PubMed / Full text
• Patterns and Perceptions of Self-Management for Osteoarthritis Pain in African American Older Adults. / 01.08.2019 / PubMed / Full text
• Use of over the counter products in older cardiovascular patients admitted to a tertiary care center in USA. / 04.12.2018 / PubMed / Full text

PARP1

• Topological DNA damage, telomere attrition and T cell senescence during chronic viral infections. / 2019 / PubMed / Full text
• PARP1 inhibitor (PJ34) improves the function of aging-induced endothelial progenitor cells by preserving intracellular NAD levels and increasing SIRT1 activity. / 23.08.2018 / PubMed / Full text
• Maternal high calorie diet induces mitochondrial dysfunction and senescence phenotype in subcutaneous fat of newborn mice. / 13.10.2017 / PubMed / Full text
• Acute telomerase components depletion triggers oxidative stress as an early event previous to telomeric shortening. / 04.2018 / PubMed / Full text

PCSK9

• Lipoprotein removal mechanisms and aging: implications for the cardiovascular health of the elderly. / 04.2020 / PubMed / Full text
• The role of proprotein convertase subtilisin-kexin type 9 (PCSK9) in the vascular aging process - is there a link? / 10.2019 / PubMed / Full text
• PCSK9 Inhibitors Show Value for Patients and the US Health Care System. / 12.2017 / PubMed / Full text
• Association between lipoprotein (a) and proprotein convertase substilisin/kexin type 9 in patients with heterozygous familial hypercholesterolemia: A case-control study. / 02.2018 / PubMed / Full text

PDK1

• Inhibition of 3-phosphoinositide-dependent protein kinase 1 (PDK1) can revert cellular senescence in human dermal fibroblasts. / 08.12.2020 / PubMed / Full text
• The Impact of the PI3K/Akt Signaling Pathway in Anxiety and Working Memory in Young and Middle-Aged PDK1 K465E Knock-In Mice. / 2020 / PubMed / Full text
• Vps15 is critical to mediate autophagy in AngII treated HUVECs probably by PDK1/PKC signaling pathway. / 15.09.2019 / PubMed / Full text
• Acupuncture Administration Improves Cognitive Functions and Alleviates Inflammation and Nuclear Damage by Regulating Phosphatidylinositol 3 Kinase (PI3K)/Phosphoinositol-Dependent Kinase 1 (PDK1)/Novel Protein Kinase C (nPKC)/Rac 1 Signaling Pathway in Senescence-Accelerated Prone 8 (SAM-P8) Mice. / 01.06.2019 / PubMed / Full text

PGF

• Long-Term Aspirin Administration Has No Effect on Erectile Function: Evidence from Adult Rats and Ageing Rat Model. / 28.05.2019 / PubMed / Full text
• In Vitro and In Vivo Antioxidant Activities of the Flowers and Leaves from Paeonia rockii and Identification of Their Antioxidant Constituents by UHPLC-ESI-HRMS via Pre-Column DPPH Reaction. / 12.02.2018 / PubMed / Full text
• Redox cycling induces spermptosis and necrosis in stallion spermatozoa while the hydroxyl radical (OH•) only induces spermptosis. / 02.2018 / PubMed / Full text
• Advanced age in mares affects endometrial secretion of arachidonic acid metabolites during equine subclinical endometritis. / 11.2017 / PubMed / Full text

PICALM

• Genetic Association between Alzheimer's Disease Risk Variant of the PICALM Gene and Auditory Event-Related Potentials in Aging. / 09.2018 / PubMed / Full text
• Integrative transcriptome analyses of the aging brain implicate altered splicing in Alzheimer's disease susceptibility. / 11.2018 / PubMed / Full text
• Recent studies on cellular and molecular mechanisms in Alzheimer's disease: focus on epigenetic factors and histone deacetylase. / 28.03.2018 / PubMed / Full text
• Alterations in endocytic protein expression with increasing age in the transgenic APP695 V717I London mouse model of amyloid pathology: implications for Alzheimer's disease. / 18.10.2017 / PubMed / Full text

PIN1

• Brain somatic mutations observed in Alzheimer's disease associated with aging and dysregulation of tau phosphorylation. / 12.07.2019 / PubMed / Full text
• Class XI Myosins Contribute to Auxin Response and Senescence-Induced Cell Death in [i]Arabidopsis[/i]. / 2018 / PubMed / Full text
• Effects of Melatonin and Its Underlying Mechanism on Ethanol-Stimulated Senescence and Osteoclastic Differentiation in Human Periodontal Ligament Cells and Cementoblasts. / 12.06.2018 / PubMed / Full text
• Integrative Analysis of Hippocampus Gene Expression Profiles Identifies Network Alterations in Aging and Alzheimer's Disease. / 2018 / PubMed / Full text

PNN

• Hyaluronan degradation and release of a hyaluronan-aggrecan complex from perineuronal nets in the aged mouse brain. / 28.11.2020 / PubMed / Full text
• Inhibition of Semaphorin3A Promotes Ocular Dominance Plasticity in the Adult Rat Visual Cortex. / 09.2019 / PubMed / Full text
• Proteomics and metabolomics identify molecular mechanisms of aging potentially predisposing for chronic lymphocytic leukemia. / 02.2018 / PubMed / Full text
• Age-dependent and region-specific alteration of parvalbumin neurons and perineuronal nets in the mouse cerebral cortex. / 01.2018 / PubMed / Full text

POLD1

• Epigenetic signatures of Werner syndrome occur early in life and are distinct from normal epigenetic aging processes. / 10.2019 / PubMed / Full text
• POLD1 deficiency is involved in cognitive function impairment in AD patients and SAMP8 mice. / 06.2019 / PubMed / Full text
• E2F1 mediates the downregulation of POLD1 in replicative senescence. / 07.2019 / PubMed / Full text
• Mandibuloacral dysplasia: A premature ageing disease with aspects of physiological ageing. / 03.2018 / PubMed / Full text

POLG

• Maternal ageing impairs mitochondrial DNA kinetics during early embryogenesis in mice. / 08.07.2019 / PubMed / Full text
• Parkin does not prevent accelerated cardiac aging in mitochondrial DNA mutator mice. / 16.04.2019 / PubMed / Full text
• The effects of AICAR and rapamycin on mitochondrial function in immortalized mitochondrial DNA mutator murine embryonic fibroblasts. / 16.11.2018 / PubMed / Full text
• Impact of exercise on oocyte quality in the POLG mitochondrial DNA mutator mouse. / 08.2018 / PubMed / Full text

RAD51

• Loss of Slug Compromises DNA Damage Repair and Accelerates Stem Cell Aging in Mammary Epithelium. / 09.07.2019 / PubMed / Full text
• Quantitative assessment of changes in cell growth, size and morphology during telomere-initiated cellular senescence in Saccharomyces cerevisiae. / 01.08.2019 / PubMed / Full text
• Mechanistic link between DNA damage sensing, repairing and signaling factors and immune signaling. / 2019 / PubMed / Full text
• The activated DNA double-strand break repair pathway in cumulus cells from aging patients may be used as a convincing predictor of poor outcomes after in vitro fertilization-embryo transfer treatment. / 2018 / PubMed / Full text

SATB1

• Loss of SATB1 Induces p21-Dependent Cellular Senescence in Post-mitotic Dopaminergic Neurons. / 03.10.2019 / PubMed / Full text
• Transcriptomic analysis of human IL-7 receptor alpha and effector memory CD8 T cells reveals an age-associated signature linked to influenza vaccine response in older adults. / 08.2019 / PubMed / Full text
• Divergent SATB1 expression across human life span and tissue compartments. / 05.2019 / PubMed / Full text
• Changes in expression of special AT-rich sequence binding protein 1 and phosphatase and tensin homologue in kidneys of diabetic rats during ageing. / 01.10.2018 / PubMed / Full text

SET

• Chromatin Modifiers SET-25 and SET-32 Are Required for Establishment but Not Long-Term Maintenance of Transgenerational Epigenetic Inheritance. / 20.11.2018 / PubMed / Full text
• SET-9 and SET-26 are H3K4me3 readers and play critical roles in germline development and longevity. / 01.05.2018 / PubMed / Full text
• Muscle-Specific Histone H3K36 Dimethyltransferase SET-18 Shortens Lifespan of Caenorhabditis elegans by Repressing daf-16a Expression. / 06.03.2018 / PubMed / Full text
• Assessing efficacy of day 3 embryo time-lapse algorithms retrospectively: impacts of dataset type and confounding factors. / 09.2019 / PubMed / Full text

SLA

• Vaccination of aged mice with adjuvanted recombinant influenza nucleoprotein enhances protective immunity. / 14.07.2020 / PubMed / Full text
• Mechanical Anisotropy and Surface Roughness in Additively Manufactured Parts Fabricated by Stereolithography (SLA) Using Statistical Analysis. / 30.05.2020 / PubMed / Full text
• The Effect of Age of Titanium Dental Implants on Implant Survival and Marginal Bone Resorption: A 5-Year Retrospective Follow-Up Study. / 01.10.2020 / PubMed / Full text
• "Spirometric" lung age reference equations: A narrative review. / 01.2018 / PubMed / Full text

SMS

• Does a Live Performance Impact Synchronization to Musical Rhythm in Cognitively Impaired Elderly? / 2020 / PubMed / Full text
• Testing the effectiveness of physical activity advice delivered via text messaging vs. human phone advisors in a Latino population: The On The Move randomized controlled trial design and methods. / 08.2020 / PubMed / Full text
• Mobile Health Interventions for Physical Activity, Sedentary Behavior, and Sleep in Adults Aged 50 Years and Older: A Systematic Literature Review. / 01.08.2019 / PubMed / Full text
• Senescence-messaging secretome factors trigger premature senescence in human endometrium-derived stem cells. / 19.02.2018 / PubMed / Full text

SOD3

• Prenatal hypoxia affected endothelium-dependent vasodilation in mesenteric arteries of aged offspring via increased oxidative stress. / 06.2019 / PubMed / Full text
• Superoxide dismutase activity is significantly lower in end-stage osteoarthritic cartilage than non-osteoarthritic cartilage. / 2018 / PubMed / Full text
• In silico analysis and molecular dynamics simulation of human superoxide dismutase 3 (SOD3) genetic variants. / 03.2019 / PubMed / Full text
• Proteomic profiling of follicle fluids after superstimulation in one-month-old lambs. / 02.2018 / PubMed / Full text

SOX9

• Positive Effects of a Young Systemic Environment and High Growth Differentiation Factor 11 Levels on Chondrocyte Proliferation and Cartilage Matrix Synthesis in Old Mice. / 07.2020 / PubMed / Full text
• Epigenetic Mechanisms Underlying the Aging of Articular Cartilage and Osteoarthritis. / 2019 / PubMed / Full text
• Co-culturing nucleus pulposus mesenchymal stem cells with notochordal cell-rich nucleus pulposus explants attenuates tumor necrosis factor-α-induced senescence. / 26.06.2018 / PubMed / Full text
• Role of CD133 Molecule in Wnt Response and Renal Repair. / 03.2018 / PubMed / Full text

TIGIT

• Impaired Cytolytic Activity and Loss of Clonal Neoantigens in Elderly Patients With Lung Adenocarcinoma. / 05.2019 / PubMed / Full text
• Multivariate Computational Analysis of Gamma Delta T Cell Inhibitory Receptor Signatures Reveals the Divergence of Healthy and ART-Suppressed HIV+ Aging. / 2018 / PubMed / Full text
• Characterization of Blimp-1 function in effector regulatory T cells. / 07.2018 / PubMed / Full text
• T-cell Immunoglobulin and ITIM Domain Contributes to CD8 T-cell Immunosenescence. / 04.2018 / PubMed / Full text

TRPA1

• Important regulatory function of transient receptor potential ankyrin 1 receptors in age-related learning and memory alterations of mice. / 10.2019 / PubMed / Full text
• Aging of mouse intervertebral disc and association with back pain. / 06.2019 / PubMed / Full text
• Congeneric variability in lifespan extension and onset of senescence suggest active regulation of aging in response to low temperature. / 12.2018 / PubMed / Full text
• A comparative study on the therapeutic effect of TRPV1, TRPA1, and TRPM8 agonists on swallowing dysfunction associated with aging and neurological diseases. / 02.2018 / PubMed / Full text

TRPV4

• TRPV4 receptor as a functional sensory molecule in bladder urothelium: Stretch-independent, tissue-specific actions and pathological implications. / 01.2020 / PubMed / Full text
• Exercise restores impaired endothelium-derived hyperpolarizing factor-mediated vasodilation in aged rat aortic arteries via the TRPV4-K 2.3 signaling complex. / 2019 / PubMed / Full text
• Autonomic dysregulation at multiple sites is implicated in age-associated underactive bladder in female mice. / 06.2019 / PubMed / Full text
• Reduced bladder responses to capsaicin and GSK-1016790A in retired-breeder female rats with diminished volume sensitivity. / 01.11.2018 / PubMed / Full text

TSC2

• AMPK/TSC2/mTOR pathway regulates replicative senescence of human vascular smooth muscle cells. / 12.2018 / PubMed / Full text
• Autophagy mediators (FOXO1, SESN3 and TSC2) in Lewy body disease and aging. / 25.09.2018 / PubMed / Full text
• FTO is involved in Alzheimer's disease by targeting TSC1-mTOR-Tau signaling. / 25.03.2018 / PubMed / Full text
• Postnatal reduction of tuberous sclerosis complex 1 expression in astrocytes and neurons causes seizures in an age-dependent manner. / 12.2017 / PubMed / Full text

A2M

• Age-Dependent Variation in Glycosylation Features of Alpha-2-Macroglobulin. / 12.2019 / PubMed / Full text
• MMP2-A2M interaction increases ECM accumulation in aged rat kidney and its modulation by calorie restriction. / 19.01.2018 / PubMed / Full text
• SPARCL1 Accelerates Symptom Onset in Alzheimer's Disease and Influences Brain Structure and Function During Aging. / 2018 / PubMed / Full text

ABCA7

• New genetic players in late-onset Alzheimer's disease: Findings of genome-wide association studies. / 08.2018 / PubMed / Full text
• Whole-Exome Sequencing of an Exceptional Longevity Cohort. / 16.08.2019 / PubMed / Full text
• Recent studies on cellular and molecular mechanisms in Alzheimer's disease: focus on epigenetic factors and histone deacetylase. / 28.03.2018 / PubMed / Full text

ABCG2

• Contribution of senescence in human endometrial stromal cells during proliferative phase to embryo receptivity†. / 23.06.2020 / PubMed / Full text
• ABCG2 rs2231142 variant in hyperuricemia is modified by SLC2A9 and SLC22A12 polymorphisms and cardiovascular risk factors in an elderly community-dwelling population. / 17.03.2020 / PubMed / Full text
• Morphological and immunohistochemical characteristics of the equine corneal epithelium. / 11.2019 / PubMed / Full text

ACLY

• In S. cerevisiae hydroxycitric acid antagonizes chronological aging and apoptosis regardless of citrate lyase. / 10.2020 / PubMed / Full text
• Dietary methionine increased the lipid accumulation in juvenile tiger puffer Takifugu rubripes. / 04.2019 / PubMed / Full text
• Spermidine reduces cancer-related mortality in humans. / 02.2019 / PubMed / Full text

ACTN3

• The Role of Genetic Profile in Functional Performance Adaptations to Exercise Training or Physical Activity: A Systematic Review of the Literature. / 01.08.2019 / PubMed / Full text
• Is evolutionary loss our gain? The role of ACTN3 p.Arg577Ter (R577X) genotype in athletic performance, ageing, and disease. / 12.2018 / PubMed / Full text
• ACTN3 genotype and physical function and frailty in an elderly Chinese population: the Rugao Longevity and Ageing Study. / 01.05.2018 / PubMed / Full text

ADM

• Assessment of age-related differences in decomposition-based quantitative EMG in the intrinsic hand muscles: A multivariate approach. / 09.2020 / PubMed / Full text
• Evaluation of transcriptional levels of the natriuretic peptides, endothelin-1, adrenomedullin, their receptors and long non-coding RNAs in rat cardiac tissue as cardiovascular biomarkers of aging. / 01.2020 / PubMed / Full text
• Development and physiological effects of an artificial diet for Wolbachia-infected Aedes aegypti. / 16.11.2017 / PubMed / Full text

AGA

• Relationship between androgenic alopecia and white matter hyperintensities in apparently healthy subjects. / 04.2020 / PubMed / Full text
• ALKB-8, a 2-Oxoglutarate-Dependent Dioxygenase and S-Adenosine Methionine-Dependent Methyltransferase Modulates Metabolic Events Linked to Lysosome-Related Organelles and Aging in C. elegans. / 2018 / PubMed
• The Impact of Being Born Preterm or Small for Gestational Age on Early Vascular Aging in Adolescents. / 10.2018 / PubMed / Full text

ALB

• Effects of Age on Inflammatory Profiles and Nutrition/Energy Metabolism in Domestic Cats. / 2020 / PubMed / Full text
• Blood Chemistry Reference Values for Free-Ranging Asiatic Black Bears ( Ursus thibetanus) by Season, Age, and Sex. / 07.2018 / PubMed / Full text
• Higher serum albumin was related with diabetes incidence and the impact of BMI changes: Based on cohort study of 18,384 Chinese male elderly. / 12.2017 / PubMed / Full text

ASXL1

• ASXL1 mutation in clonal hematopoiesis. / 03.2020 / PubMed / Full text
• [Role of ASXL1 mutations in hematological disorders]. / 2019 / PubMed / Full text
• Clonal hematopoiesis: Genes and underlying mechanisms in cardiovascular disease development. / 06.2019 / PubMed / Full text

ATRX

• ATRX-DAXX Complex Expression Levels and Telomere Length in Normal Young and Elder Autopsy Human Brains. / 09.2019 / PubMed / Full text
• Inactivation of hepatic ATRX in [i]Atrx[/i] Foxg1cre mice prevents reversal of aging-like phenotypes by thyroxine. / 07.06.2018 / PubMed / Full text
• Mechanistic understanding of the role of ATRX in senescence provides new insight for combinatorial therapies with CDK4 inhibitors. / 2018 / PubMed / Full text

BAD

• I imidazoline receptor modulation protects aged SAMP8 mice against cognitive decline by suppressing the calcineurin pathway. / 31.10.2020 / PubMed / Full text
• Xanthohumol exerts protective effects in liver alterations associated with aging. / 03.2019 / PubMed / Full text
• Protective effect of xanthohumol against age-related brain damage. / 11.2017 / PubMed / Full text

BATF

• LncRNA-ES3 inhibition by Bhlhe40 is involved in high glucose-induced calcification/senescence of vascular smooth muscle cells. / 08.2020 / PubMed / Full text
• Transcription factor networks in aged naïve CD4 T cells bias lineage differentiation. / 08.2019 / PubMed / Full text
• Transcriptomic analysis of human IL-7 receptor alpha and effector memory CD8 T cells reveals an age-associated signature linked to influenza vaccine response in older adults. / 08.2019 / PubMed / Full text

BLM

• [Olmesartan inhibits age-associated migration and invasion of human aortic vascular smooth muscle cells by upregulating miR-3133 axis]. / 30.04.2020 / PubMed / Full text
• Genomic instability and DNA replication defects in progeroid syndromes. / 31.12.2018 / PubMed / Full text
• Human RecQL4 helicase plays multifaceted roles in the genomic stability of normal and cancer cells. / 28.01.2018 / PubMed / Full text

BMI1

• Senescence Induced by BMI1 Inhibition Is a Therapeutic Vulnerability in H3K27M-Mutant DIPG. / 20.10.2020 / PubMed / Full text
• microRNA-31 inhibition partially ameliorates the deficiency of bone marrow stromal cells from cleidocranial dysplasia. / 06.2019 / PubMed / Full text
• Timosaponin A-III inhibits oncogenic phenotype via regulation of PcG protein BMI1 in breast cancer cells. / 07.2018 / PubMed / Full text

BMP2

• Interleukin-1β-Induced Senescence Promotes Osteoblastic Transition of Vascular Smooth Muscle Cells. / 2020 / PubMed / Full text
• Long noncoding RNA Bmncr regulates mesenchymal stem cell fate during skeletal aging. / 03.12.2018 / PubMed / Full text
• Synthesis of Extracellular Pyrophosphate Increases in Vascular Smooth Muscle Cells During Phosphate-Induced Calcification. / 09.2018 / PubMed / Full text

BMP4

• Direct reprogramming of human smooth muscle and vascular endothelial cells reveals defects associated with aging and Hutchinson-Gilford progeria syndrome. / 08.09.2020 / PubMed / Full text
• Interplay between Follistatin, Activin A, and BMP4 Signaling Regulates Postnatal Thymic Epithelial Progenitor Cell Differentiation during Aging. / 25.06.2019 / PubMed / Full text
• Centenarians Overexpress Pluripotency-Related Genes. / 16.08.2019 / PubMed / Full text

BPI

• High TARC plasma levels confer protection to long living individuals by inducing M2 profile. / 01.2021 / PubMed / Full text
• Circulating BPIFB4 Levels Associate With and Influence the Abundance of Reparative Monocytes and Macrophages in Long Living Individuals. / 2020 / PubMed / Full text
• The effect of postural deformities on back function and pain in patients with Parkinson's disease. / 2019 / PubMed / Full text

CCL3

• Microglial translational profiling reveals a convergent APOE pathway from aging, amyloid, and tau. / 03.09.2018 / PubMed / Full text
• Time-Dependent Changes in Local and Serum Levels of Inflammatory Cytokines as Markers for Incised Wound Aging of Skeletal Muscles. / 05.2018 / PubMed / Full text
• Age-related pro-inflammatory and pro-angiogenic changes in human aqueous humor. / 2018 / PubMed / Full text

CCN1

• Sodium tanshinone IIA sulfonate restrains fibrogenesis through induction of senescence in mice with induced deep endometriosis. / 09.2020 / PubMed / Full text
• Inhibition of cellular communication network factor 1 (CCN1)-driven senescence slows down cartilage inflammaging and osteoarthritis. / 10.2020 / PubMed / Full text
• The senescence-associated matricellular protein CCN1 in plasma of human subjects with idiopathic pulmonary fibrosis. / 01.2020 / PubMed / Full text

CCNB1

• Antioxidant hesperetin improves the quality of porcine oocytes during aging in vitro. / 01.2019 / PubMed / Full text
• Effect of CCNB1 silencing on cell cycle, senescence, and apoptosis through the p53 signaling pathway in pancreatic cancer. / 01.2018 / PubMed / Full text
• Hypoxia Upregulates Mitotic Cyclins Which Contribute to the Multipotency of Human Mesenchymal Stem Cells by Expanding Proliferation Lifespan. / 31.03.2018 / PubMed / Full text

CCR5

• [Enhancement can do harm]. / 08-09.2019 / PubMed / Full text
• CCR5-∆32 is deleterious in the homozygous state in humans. / 06.2019 / PubMed / Full text
• CCR5 chemokine receptor gene polymorphisms in ocular toxoplasmosis. / 02.2018 / PubMed / Full text

CD24

• CD24 expression indicates healthier phenotype and less tendency of cellular senescence in human nucleus pulposus cells. / 12.2019 / PubMed / Full text
• Innate and adaptive immune dysregulation in critically ill ICU patients. / 05.07.2018 / PubMed / Full text
• Some chemotherapeutics-treated colon cancer cells display a specific phenotype being a combination of stem-like and senescent cell features. / 02.01.2018 / PubMed / Full text

CD81

• Ovarian aging increases small extracellular vesicle CD81 release in human follicular fluid and influences miRNA profiles. / 17.06.2020 / PubMed / Full text
• Older Adults with Physical Frailty and Sarcopenia Show Increased Levels of Circulating Small Extracellular Vesicles with a Specific Mitochondrial Signature. / 15.04.2020 / PubMed / Full text
• Increased production of functional small extracellular vesicles in senescent endothelial cells. / 04.2020 / PubMed / Full text

CD9

• Exosomal Notch3 from high glucose-stimulated endothelial cells regulates vascular smooth muscle cells calcification/aging. / 01.09.2019 / PubMed / Full text
• Effects of RSC96 Schwann Cell-Derived Exosomes on Proliferation, Senescence, and Apoptosis of Dorsal Root Ganglion Cells In Vitro. / 02.11.2018 / PubMed / Full text
• Identification of functionally distinct fibro-inflammatory and adipogenic stromal subpopulations in visceral adipose tissue of adult mice. / 28.09.2018 / PubMed / Full text

CDC42

• Effects of age-dependent changes in cell size on endothelial cell proliferation and senescence through YAP1. / 05.09.2019 / PubMed / Full text
• Re-exploring the core genes and modules in the human frontal cortex during chronological aging: insights from network-based analysis of transcriptomic studies. / 20.10.2018 / PubMed / Full text
• The relationship between reproductive and biochemical ageing at the time of the menopausal transition. / 11.2017 / PubMed / Full text

CDK5

• Age-related hyperinsulinemia leads to insulin resistance in neurons and cell-cycle-induced senescence. / 11.2019 / PubMed / Full text
• CK2 inhibition protects white matter from ischemic injury. / 20.11.2018 / PubMed / Full text
• CK2 inhibition confers functional protection to young and aging axons against ischemia by differentially regulating the CDK5 and AKT signaling pathways. / 06.2019 / PubMed / Full text

COMP

• Effect of circadian rhythm, age, training and acute lameness on serum concentrations of cartilage oligomeric matrix protein (COMP) neo-epitope in horses. / 09.2019 / PubMed / Full text
• Genetic overexpression of COMP-Ang1 impairs BM microenvironment and induces senescence of BM HSCs. / 15.05.2018 / PubMed / Full text
• Longitudinal Twin Study of Subjective Health: Differences in Genetic and Environmental Components of Variance Across Age and Sex. / 01.01.2020 / PubMed / Full text

CPT1C

• Carnitine palmitoyltransferase 1C reverses cellular senescence of MRC-5 fibroblasts via regulating lipid accumulation and mitochondrial function. / 02.2021 / PubMed / Full text
• Carnitine palmitoyltransferase 1C contributes to progressive cellular senescence. / 14.04.2020 / PubMed / Full text
• Effects of carnitine palmitoyltransferases on cancer cellular senescence. / 02.2019 / PubMed / Full text

CRY1

• Karyopherin Alpha 2-Expressing Pancreatic Duct Glands and Intra-Islet Ducts in Aged Diabetic C414A-Mutant-CRY1 Transgenic Mice. / 2019 / PubMed / Full text
• Investigating circadian clock gene expression in human tendon biopsies from acute exercise and immobilization studies. / 06.2019 / PubMed / Full text
• Is the aging human ovary still ticking?: Expression of clock-genes in luteinized granulosa cells of young and older women. / 21.11.2018 / PubMed / Full text

CTCF

• New targeted approaches for epigenetic age predictions. / 24.06.2020 / PubMed / Full text
• Genetic Insights Into Frailty: Association of 9p21-23 Locus With Frailty. / 2018 / PubMed / Full text
• HMGB2 Loss upon Senescence Entry Disrupts Genomic Organization and Induces CTCF Clustering across Cell Types. / 17.05.2018 / PubMed / Full text

CTH

• Anterior Cingulate Structure and Perfusion is Associated with Cerebrospinal Fluid Tau among Cognitively Normal Older Adult APOEɛ4 Carriers. / 2020 / PubMed / Full text
• Curious CXR. / 07.2019 / PubMed / Full text
• Mechanochemical Catalytic Transfer Hydrogenation of Aromatic Nitro Derivatives. / 30.11.2018 / PubMed / Full text

CTNNB1

• [i]TP53[/i] Tumor-suppressor Gene Plays a Key Role in IGF1 Signaling Pathway Related to the Aging of Human Melanocytes. / 05.2019 / PubMed / Full text
• Identification of key genes and transcription factors in aging mesenchymal stem cells by DNA microarray data. / 15.04.2019 / PubMed / Full text
• Proteomic profiling of follicle fluids after superstimulation in one-month-old lambs. / 02.2018 / PubMed / Full text

CTSB

• Myocardial cathepsin D is downregulated in sudden cardiac death. / 2020 / PubMed / Full text
• A Free Radical-Generating System Regulates Amyloid Oligomers: Involvement of Cathepsin B. / 2018 / PubMed / Full text
• SIRT6 histone deacetylase functions as a potential oncogene in human melanoma. / 09.2017 / PubMed / Full text

CYP2J2

• The effects of endothelium-specific CYP2J2 overexpression on the attenuation of retinal ganglion cell apoptosis in a glaucoma rat model. / 10.2019 / PubMed / Full text
• Regional vulnerability to lipoxidative damage and inflammation in normal human brain aging. / 01.10.2018 / PubMed / Full text
• Endothelium-specific CYP2J2 overexpression attenuates age-related insulin resistance. / 04.2018 / PubMed / Full text

DCT

• Changes in expression of special AT-rich sequence binding protein 1 and phosphatase and tensin homologue in kidneys of diabetic rats during ageing. / 01.10.2018 / PubMed / Full text
• Evaluation of the NAL Dynamic Conversations Test in older listeners with hearing loss. / 03.2018 / PubMed / Full text
• Dihydrocapsiate improved age-associated impairments in mice by increasing energy expenditure. / 01.11.2017 / PubMed / Full text

DDC

• N-Acetyl Cysteine Attenuates the Sarcopenia and Muscle Apoptosis Induced by Chronic Liver Disease. / 2019 / PubMed / Full text
• Aging-Related Expression of Twinfilin-1 Regulates Cholangiocyte Biological Response to Injury. / 09.2019 / PubMed / Full text
• Life History of Parthenolecanium spp. (Hemiptera: Coccidae) in Urban Landscapes of the Southeastern United States. / 01.08.2017 / PubMed / Full text

DDO

• New insights on the influence of free d-aspartate metabolism in the mammalian brain during prenatal and postnatal life. / 10.2020 / PubMed / Full text
• Free d-aspartate triggers NMDA receptor-dependent cell death in primary cortical neurons and perturbs JNK activation, Tau phosphorylation, and protein SUMOylation in the cerebral cortex of mice lacking d-aspartate oxidase activity. / 07.2019 / PubMed / Full text
• Secreted d-aspartate oxidase functions in C. elegans reproduction and development. / 01.2019 / PubMed / Full text

DKK1

• Low Serum Levels of DKK2 Predict Incident Low-Impact Fracture in Older Women. / 07.2019 / PubMed / Full text
• Involvement of p38 in Age-Related Decline in Adult Neurogenesis via Modulation of Wnt Signaling. / 11.06.2019 / PubMed / Full text
• [Role and alterations of DNA methylation during the aging and cancer]. / 01.2018 / PubMed / Full text

DLD

• A preliminary study of cerebral blood flow, aging and dementia in people with Down syndrome. / 12.2020 / PubMed / Full text
• Premature senescence activation in DLD-1 colorectal cancer cells through adjuvant therapy to induce a miRNA profile modulating cellular death. / 08.2018 / PubMed / Full text
• Immature Auditory Evoked Potentials in Children With Moderate-Severe Developmental Language Disorder. / 13.07.2018 / PubMed / Full text

DNMT3B

• Alcohol Extracts From [i]Ganoderma lucidum[/i] Delay the Progress of Alzheimer's Disease by Regulating DNA Methylation in Rodents. / 2019 / PubMed / Full text
• Human iPSC-derived MSCs (iMSCs) from aged individuals acquire a rejuvenation signature. / 18.03.2019 / PubMed / Full text
• Effects of Parental Aging During Embryo Development and Adult Life: The Case of Nothobranchius furzeri. / 04.2018 / PubMed / Full text

EP300

• Identification of key genes and transcription factors in aging mesenchymal stem cells by DNA microarray data. / 15.04.2019 / PubMed / Full text
• Aspirin-another caloric-restriction mimetic. / 2018 / PubMed / Full text
• Aspirin Recapitulates Features of Caloric Restriction. / 27.02.2018 / PubMed / Full text

FABP3

• FABP3-mediated membrane lipid saturation alters fluidity and induces ER stress in skeletal muscle with aging. / 09.11.2020 / PubMed / Full text
• Autophagy receptor OPTN (optineurin) regulates mesenchymal stem cell fate and bone-fat balance during aging by clearing FABP3. / 04.11.2020 / PubMed / Full text
• Myokines as biomarkers of frailty and cardiovascular disease risk in females. / 05.2020 / PubMed / Full text

FIS1

• A mitochondrial FUNDC1/HSC70 interaction organizes the proteostatic stress response at the risk of cell morbidity. / 01.02.2019 / PubMed / Full text
• Increased Degradation Rates in the Components of the Mitochondrial Oxidative Phosphorylation Chain in the Cerebellum of Old Mice. / 2018 / PubMed / Full text
• Proteomics and metabolomics identify molecular mechanisms of aging potentially predisposing for chronic lymphocytic leukemia. / 02.2018 / PubMed / Full text

FOS

• Muscle atrophy-related myotube-derived exosomal microRNA in neuronal dysfunction: Targeting both coding and long noncoding RNAs. / 05.2020 / PubMed / Full text
• Dietary Fructooligosaccharide and Glucomannan Alter Gut Microbiota and Improve Bone Metabolism in Senescence-Accelerated Mouse. / 23.01.2019 / PubMed / Full text
• Novel molecular mechanisms for the adaptogenic effects of herbal extracts on isolated brain cells using systems biology. / 15.11.2018 / PubMed / Full text

FOXP1

• GATA6 regulates aging of human mesenchymal stem/stromal cells. / 30.11.2020 / PubMed / Full text
• Identification of the neurotransmitter profile of AmFoxP expressing neurons in the honeybee brain using double-label in situ hybridization. / 06.11.2018 / PubMed / Full text
• Downregulation of FOXP1 correlates with tendon stem/progenitor cells aging. / 26.09.2018 / PubMed / Full text

FYN

• An inhibitor role of Nrf2 in the regulation of myocardial senescence and dysfunction after myocardial infarction. / 15.10.2020 / PubMed / Full text
• Identification of key genes and transcription factors in aging mesenchymal stem cells by DNA microarray data. / 15.04.2019 / PubMed / Full text
• Cell fate regulation by reticulon-4 in human prostate cancers. / 07.2019 / PubMed / Full text

GBA

• Reduced sphingolipid hydrolase activities, substrate accumulation and ganglioside decline in Parkinson's disease. / 08.11.2019 / PubMed / Full text
• Glycosphingolipid levels and glucocerebrosidase activity are altered in normal aging of the mouse brain. / 07.2018 / PubMed / Full text
• GBA mutations in Parkinson disease: earlier death but similar neuropathological features. / 11.2017 / PubMed / Full text

GCLC

• Aerobic exercise training partially reverses the impairment of Nrf2 activation in older humans. / 20.11.2020 / PubMed / Full text
• Ontogeny and aging of Nrf2 pathway genes in livers of rats. / 15.06.2018 / PubMed / Full text
• Proteomic profiling of follicle fluids after superstimulation in one-month-old lambs. / 02.2018 / PubMed / Full text

GEM

• The Impact of Geriatric Emergency Management Nurses on the Care of Frail Older Patients in the Emergency Department: a Systematic Review. / 09.2020 / PubMed / Full text
• Cytosolic and mitochondrial Ca concentrations in primary hepatocytes change with ageing and in consequence of an mtDNA mutation. / 09.2019 / PubMed / Full text
• Understanding of diagnosis and medications among non-English-speaking older patients. / 06.2018 / PubMed / Full text

GPI

• Blood factors transfer beneficial effects of exercise on neurogenesis and cognition to the aged brain. / 10.07.2020 / PubMed / Full text
• Potential role of exercise-induced glucose-6-phosphate isomerase in skeletal muscle function. / 30.06.2019 / PubMed / Full text
• Red Blood Cell Homeostasis and Altered Vesicle Formation in Patients With Paroxysmal Nocturnal Hemoglobinuria. / 2019 / PubMed / Full text

GPX1

• Glutathione peroxidase-1 overexpression reduces oxidative stress, and improves pathology and proteome remodeling in the kidneys of old mice. / 06.2020 / PubMed / Full text
• Effect of β-D-Mannuronic Acid (M2000) on Oxidative Stress Enzymes' Gene Using Healthy Donor Peripheral Blood Mononuclear Cells for Evaluating the Anti-Aging Property. / 2019 / PubMed / Full text
• The impact of preserved Klotho gene expression on antioxidative stress activity in healthy kidney. / 01.08.2018 / PubMed / Full text

GPX4

• l-carnitine supplementation during in vitro culture regulates oxidative stress in embryos from bovine aged oocytes. / 02.2020 / PubMed / Full text
• Dietary Selenium Supplementation Ameliorates Female Reproductive Efficiency in Aging Mice. / 11.12.2019 / PubMed / Full text
• Resveratrol improves in vitro maturation of oocytes in aged mice and humans. / 05.2018 / PubMed / Full text

GSS

• Geriatric brain tumor management part I: Meningioma. / 09.2019 / PubMed / Full text
• Link between cardiac function and the antioxidative defense mechanism in aged rats. / 11.06.2019 / PubMed / Full text
• Towards improving sterile insect technique: Exposure to orange oil compounds increases sexual signalling and longevity in Ceratitis capitata males of the Vienna 8 GSS. / 2017 / PubMed / Full text

GSTM1

• The effects of everyday-life exposure to polycyclic aromatic hydrocarbons on biological age indicators. / 03.12.2020 / PubMed / Full text
• Carrying the T Allele of the SNP rs574344, an eQTL of GSTM1, Contributes to Longevity in the Han Chinese Population. / 01.2019 / PubMed / Full text
• Age-associated changes in GSH S-transferase gene/proteins in livers of rats. / 12.2018 / PubMed / Full text

HDAC4

• The posttranslational modification of HDAC4 in cell biology: Mechanisms and potential targets. / 02.2020 / PubMed / Full text
• Exercise preconditioning attenuates hind limb unloading-induced gastrocnemius muscle atrophy possibly via the HDAC4/Gadd45 axis in old rats. / 15.07.2019 / PubMed / Full text
• Novel anti-aging gene NM_026333 contributes to proton-induced aging via NCX1-pathway. / 12.2018 / PubMed / Full text

HFE

• Polyphenol Characterization and Skin-Preserving Properties of Hydroalcoholic Flower Extract from [i]Himantoglossum robertianum[/i] (Orchidaceae). / 14.11.2019 / PubMed / Full text
• Hydroalcoholic extract of Spartium junceum L. flowers inhibits growth and melanogenesis in B16-F10 cells by inducing senescence. / 15.07.2018 / PubMed / Full text
• Iron-processing genotypes, nutrient intakes, and cadmium levels in the Normative Aging Study: Evidence of sensitive subpopulations in cadmium risk assessment. / 10.2018 / PubMed / Full text

HMGA2

• 4D Genome Rewiring during Oncogene-Induced and Replicative Senescence. / 07.05.2020 / PubMed / Full text
• The protective effects of HMGA2 in the senescence process of bone marrow-derived mesenchymal stromal cells. / 04.2020 / PubMed / Full text
• Epigallocatechin-3-gallate and BIX-01294 have different impact on epigenetics and senescence modulation in acute and chronic myeloid leukemia cells. / 05.11.2018 / PubMed / Full text

HSPA8

• Influence of Normal Aging on Brain Autophagy: A Complex Scenario. / 2019 / PubMed / Full text
• Nitric oxide contributes to protein homeostasis by S-nitrosylations of the chaperone HSPA8 and the ubiquitin ligase UBE2D. / 01.2019 / PubMed / Full text
• Cerebrospinal Fluid Concentration of Key Autophagy Protein Lamp2 Changes Little During Normal Aging. / 2018 / PubMed / Full text

ICOS

• The Regulatory Status Adopted by Lymph Node Dendritic Cells and T Cells During Healthy Aging Is Maintained During Cancer and May Contribute to Reduced Responses to Immunotherapy. / 2018 / PubMed / Full text
• End-stage renal disease, dialysis, kidney transplantation and their impact on CD4 T-cell differentiation. / 10.2018 / PubMed / Full text
• Characterization of Blimp-1 function in effector regulatory T cells. / 07.2018 / PubMed / Full text

IGFBP5

• Intracellular Heat Shock Protein 70 Deficiency in Pulmonary Fibrosis. / 06.2019 / PubMed / Full text
• Blunted satellite cell response is associated with dysregulated IGF-1 expression after exercise with age. / 10.2018 / PubMed / Full text
• Material-induced Senescence (MIS): Fluidity Induces Senescent Type Cell Death of Lung Cancer Cells via Insulin-Like Growth Factor Binding Protein 5. / 2017 / PubMed / Full text

IL2

• Impact of Aging on the Phenotype of Invariant Natural Killer T Cells in Mouse Thymus. / 2020 / PubMed / Full text
• Redox, immune and genetic biomarker system for personalized treatments in colorectal cancer. / 15.02.2019 / PubMed / Full text
• Low IL-2 Expressing T Cells in Thalassemia Major Patients: Is It Immune Aging. / 10.2018 / PubMed / Full text

ILK

• Age-dependent skeletal muscle transcriptome response to bed rest-induced atrophy. / 01.04.2019 / PubMed / Full text
• Hyperphosphatemia Promotes Senescence of Myoblasts by Impairing Autophagy Through Ilk Overexpression, A Possible Mechanism Involved in Sarcopenia. / 10.2018 / PubMed / Full text
• Integrin-linked kinase: A new actor in the ageing process? / 15.12.2017 / PubMed / Full text

IPP

• Toxic effect of the novel chiral insecticide IPP and its biodegradation intermediate in nematode Caenorhabditis elegans. / 30.11.2018 / PubMed / Full text
• The inositol pyrophosphate pathway in health and diseases. / 05.2018 / PubMed / Full text
• Integrin-linked kinase: A new actor in the ageing process? / 15.12.2017 / PubMed / Full text

IRF8

• IRF8 induces senescence of lung cancer cells to exert its tumor suppressive function. / 12.2019 / PubMed / Full text
• Epigenome-wide exploratory study of monozygotic twins suggests differentially methylated regions to associate with hand grip strength. / 10.2019 / PubMed / Full text
• Aging impairs both primary and secondary RIG-I signaling for interferon induction in human monocytes. / 12.12.2017 / PubMed / Full text

KIN

• The noncanonical small heat shock protein HSP-17 from [i]Caenorhabditis elegans[/i] is a selective protein aggregase. / 06.03.2020 / PubMed / Full text
• KIN-4/MAST kinase promotes PTEN-mediated longevity of Caenorhabditis elegans via binding through a PDZ domain. / 06.2019 / PubMed / Full text
• Adenine type and diphenyl urea derived cytokinins improve the postharvest performance of [i]Iris germanica[/i] L. cut scapes. / 11.2018 / PubMed / Full text

KLRG1

• Are skin senescence and immunosenescence linked within individuals? / 08.2019 / PubMed / Full text
• Increased T cell immunosenescence and accelerated maturation phenotypes in older kidney transplant recipients. / 09.2018 / PubMed / Full text
• Impact of Aging on the Frequency, Phenotype, and Function of CD161-Expressing T Cells. / 2018 / PubMed / Full text

LAMP1

• Differential accumulation of storage bodies with aging defines discrete subsets of microglia in the healthy brain. / 24.06.2020 / PubMed / Full text
• A pH probe inhibits senescence in mesenchymal stem cells. / 07.12.2018 / PubMed / Full text
• Alterations in Corneal Sensory Nerves During Homeostasis, Aging, and After Injury in Mice Lacking the Heparan Sulfate Proteoglycan Syndecan-1. / 01.10.2017 / PubMed / Full text

LPL

• Survival analyses in Holstein cows considering direct disease diagnoses and specific SNP marker effects. / 09.2020 / PubMed / Full text
• Influence of common health disorders on the length of productive life and stayability in German Holstein cows. / 01.2020 / PubMed / Full text
• GH prevents adipogenic differentiation of mesenchymal stromal stem cells derived from human trabecular bone via canonical Wnt signaling. / 07.2018 / PubMed / Full text

LSS

• Surgical results in older patients with lumbar spinal stenosis according to gait speed in relation to the diagnosis for sarcopenia. / 01-04.2020 / PubMed / Full text
• Streamlining an existing hip fracture patient pathway in an acute tertiary adult Irish hospital to improve patient experience and outcomes. / 22.12.2019 / PubMed / Full text
• Low-dose radiation from A-bombs elongated lifespan and reduced cancer mortality relative to un-irradiated individuals. / 2018 / PubMed / Full text

MAPK1

• Purified Vitexin Compound 1 Inhibits UVA-Induced Cellular Senescence in Human Dermal Fibroblasts by Binding Mitogen-Activated Protein Kinase 1. / 2020 / PubMed / Full text
• Identification of key genes and transcription factors in aging mesenchymal stem cells by DNA microarray data. / 15.04.2019 / PubMed / Full text
• Integrative Analysis of Hippocampus Gene Expression Profiles Identifies Network Alterations in Aging and Alzheimer's Disease. / 2018 / PubMed / Full text

MEF2A

• Myocyte enhancer factor 2A delays vascular endothelial cell senescence by activating the PI3K/p-Akt/SIRT1 pathway. / 10.06.2019 / PubMed / Full text
• MEF2A alters the proliferation, inflammation-related gene expression profiles and its silencing induces cellular senescence in human coronary endothelial cells. / 18.03.2019 / PubMed / Full text
• Identification of key genes and transcription factors in aging mesenchymal stem cells by DNA microarray data. / 15.04.2019 / PubMed / Full text

MGA

• Fatigue at baseline is associated with geriatric impairments and represents an adverse prognostic factor in older patients with a hematological malignancy. / 11.2018 / PubMed / Full text
• Geriatric assessment in oncology: Moving the concept forward. The 20 years of experience of the Centre Léon Bérard geriatric oncology program. / 11.2018 / PubMed / Full text
• Degree of Peripheral Thyroxin Deiodination, Frailty, and Long-Term Survival in Hospitalized Older Patients. / 01.05.2018 / PubMed / Full text

MLKL

• Remifentanil preconditioning protects against hypoxia-induced senescence and necroptosis in human cardiac myocytes [i]in vitro[/i]. / 25.06.2020 / PubMed / Full text
• Necroptosis increases with age and is reduced by dietary restriction. / 08.2018 / PubMed / Full text
• RIPK1-RIPK3-MLKL-dependent necrosis promotes the aging of mouse male reproductive system. / 15.08.2017 / PubMed / Full text

MLN

• Age-Dependent Decrease in the Induction of Regulatory T Cells Is Associated With Decreased Expression of RALDH2 in Mesenteric Lymph Node Dendritic Cells. / 2020 / PubMed / Full text
• Variability of Spleen and Mesenteric Lymph Node in Control Cynomolgus Monkeys ( Macaca fascicularis) from Nonclinical Safety Studies: A Retrospective Assessment. / 01.2019 / PubMed / Full text
• Microanatomical dissection of human intestinal T-cell immunity reveals site-specific changes in gut-associated lymphoid tissues over life. / 03.2019 / PubMed / Full text

MTR

• Amide proton transfer-weighted magnetic resonance imaging of human brain aging at 3 Tesla. / 03.2020 / PubMed / Full text
• One-carbon metabolism gene polymorphisms are associated with cognitive trajectory among African-American adults. / 12.2019 / PubMed / Full text
• Test-retest reliability of myelin imaging in the human spinal cord: Measurement errors versus region- and aging-induced variations. / 2018 / PubMed / Full text

NES

• Mini-review: Aging of the neuroendocrine system: Insights from nonhuman primate models. / 08.06.2020 / PubMed / Full text
• Age Dependent Hypothalamic and Pituitary Responses to Novel Environment Stress or Lipopolysaccharide in Rats. / 2018 / PubMed / Full text
• [Prediction of life expectancy for prostate cancer patients based on the kinetic theory of aging of living systems]. / 2017 / PubMed

NFE2L2

• The double-edged sword of MTOR in autophagy deficiency induced-liver injury and tumorigenesis. / 09.2019 / PubMed / Full text
• The Association of a Single-Nucleotide Polymorphism in the Nuclear Factor (Erythroid-Derived 2)-Like 2 Gene With Adverse Drug Reactions, Multimorbidity, and Frailty in Older People. / 22.05.2020 / PubMed / Full text
• Immunohistochemical localization of Nrf2 in the human cochlea. / 01.12.2018 / PubMed / Full text

NOS1

• Prepubertal overexposure to manganese induce precocious puberty through GABA receptor/nitric oxide pathway in immature female rats. / 30.01.2020 / PubMed / Full text
• Genetic background, epigenetic factors and dietary interventions which influence human longevity. / 10.2019 / PubMed / Full text
• NOS3 Inhibition Confers Post-Ischemic Protection to Young and Aging White Matter Integrity by Conserving Mitochondrial Dynamics and Miro-2 Levels. / 11.07.2018 / PubMed / Full text

NOS3

• Application of Oxidative Stress to a Tissue-Engineered Vascular Aging Model Induces Endothelial Cell Senescence and Activation. / 22.05.2020 / PubMed / Full text
• Hypertension and longevity: role of genetic polymorphisms in renin-angiotensin-aldosterone system and endothelial nitric oxide synthase. / 05.2019 / PubMed / Full text
• NOS3 Inhibition Confers Post-Ischemic Protection to Young and Aging White Matter Integrity by Conserving Mitochondrial Dynamics and Miro-2 Levels. / 11.07.2018 / PubMed / Full text

NRF1

• Maternal ageing impairs mitochondrial DNA kinetics during early embryogenesis in mice. / 08.07.2019 / PubMed / Full text
• Photobiomodulation and Coenzyme Q Treatments Attenuate Cognitive Impairment Associated With Model of Transient Global Brain Ischemia in Artificially Aged Mice. / 2019 / PubMed / Full text
• Androgen receptor polyglutamine expansion drives age-dependent quality control defects and muscle dysfunction. / 01.08.2018 / PubMed / Full text

OGT

• ELT-2 promotes O-GlcNAc transferase OGT-1 expression to modulate Caenorhabditis elegans lifespan. / 06.07.2020 / PubMed / Full text
• Neuronal O-GlcNAcylation Improves Cognitive Function in the Aged Mouse Brain. / 21.10.2019 / PubMed / Full text
• Schwann cell O-GlcNAcylation promotes peripheral nerve remyelination via attenuation of the AP-1 transcription factor JUN. / 31.07.2018 / PubMed / Full text

OXTR

• Association of oxytocin levels and oxytocin receptor gene polymorphism (rs2254298) with cardiovascular risk factors in Brazilian elderly from Primary Health Care. / 09-10.2019 / PubMed / Full text
• Impact of housing conditions on social behavior, neuroimmune markers, and oxytocin receptor expression in aged male and female Fischer 344 rats. / 08.2019 / PubMed / Full text
• Associations between oxytocin receptor gene (OXTR) methylation, plasma oxytocin, and attachment across adulthood. / 02.2019 / PubMed / Full text

PFAS

• Associations between serum concentrations of perfluoroalkyl substances and DNA methylation in women exposed through drinking water: A pilot study in Ronneby, Sweden. / 12.2020 / PubMed / Full text
• Perfluorinated alkyl substances impede growth, reproduction, lipid metabolism and lifespan in Daphnia magna. / 01.10.2020 / PubMed / Full text
• The effect of weathering on per- and polyfluoroalkyl substances (PFASs) from durable water repellent (DWR) clothing. / 06.2020 / PubMed / Full text

PI3

• Pulmonary Diseases and Ageing. / 2019 / PubMed / Full text
• CD57 identifies T cells with functional senescence before terminal differentiation and relative telomere shortening in patients with activated PI3 kinase delta syndrome. / 11.2018 / PubMed / Full text
• Maternal diabetes up-regulates NOX2 and enhances myocardial ischaemia/reperfusion injury in adult offspring. / 04.2018 / PubMed / Full text

PLAU

• Identification of key genes and transcription factors in aging mesenchymal stem cells by DNA microarray data. / 15.04.2019 / PubMed / Full text
• Towards frailty biomarkers: Candidates from genes and pathways regulated in aging and age-related diseases. / 11.2018 / PubMed / Full text
• G protein-coupled receptor kinase 4-induced cellular senescence and its senescence-associated gene expression profiling. / 15.11.2017 / PubMed / Full text

PNP

• Temporal Discrimination Thresholds and Proprioceptive Performance: Impact of Age and Nerve Conduction. / 2019 / PubMed / Full text
• Polyneuropathy in Severely Obese Women Without Diabetes: Prevalence and Associated Factors. / 03.2019 / PubMed / Full text
• Electrophysiological evidence for preserved primacy of lexical prediction in aging. / 08.2018 / PubMed / Full text

POR

• The Ventricular System Enlarges Abnormally in the Seventies, Earlier in Men, and First in the Frontal Horn: A Study Based on More Than 3,000 Scans. / 2019 / PubMed / Full text
• Clinical findings associated with development of postoperative reflux and short-term survival after small intestinal surgery in geriatric and mature nongeriatric horses. / 07.2019 / PubMed / Full text
• Effect of Age and Allele Variants of CYP3A5, CYP3A4, and POR Genes on the Pharmacokinetics of Cyclosporin A in Pediatric Renal Transplant Recipients From Serbia. / 12.2017 / PubMed / Full text

PRDX1

• Active vitamin D supplementation alleviates initiation and progression of nonalcoholic fatty liver disease by repressing the p53 pathway. / 15.01.2020 / PubMed / Full text
• PRDX1 and MTH1 cooperate to prevent ROS-mediated inhibition of telomerase. / 01.05.2018 / PubMed / Full text
• Proteomic profiling of follicle fluids after superstimulation in one-month-old lambs. / 02.2018 / PubMed / Full text

PRDX3

• Proteomic analyses reveal that ginsenoside Rg3([i]S[/i]) partially reverses cellular senescence in human dermal fibroblasts by inducing peroxiredoxin. / 01.2020 / PubMed / Full text
• Late life maintenance and enhancement of functional exercise capacity in low and high responding rats after low intensity treadmill training. / 01.10.2019 / PubMed / Full text
• The impact of preserved Klotho gene expression on antioxidative stress activity in healthy kidney. / 01.08.2018 / PubMed / Full text

PVR

• Age estimation based on the volume change in the maxillary premolar crown using micro CT. / 03.2019 / PubMed / Full text
• Effect of age on the presence of comet tails at high altitude. / 01.2019 / PubMed / Full text
• Natural history of post-void residual urine volume over 5 years in community-dwelling older men: The Concord Health and Ageing in Men Project. / 03.2018 / PubMed / Full text

RHEB

• The Rheb-TORC1 signaling axis functions as a developmental checkpoint. / 02.03.2020 / PubMed / Full text
• Long-lived rodents reveal signatures of positive selection in genes associated with lifespan. / 03.2018 / PubMed / Full text
• CGEF-1 regulates mTORC1 signaling during adult longevity and stress response in [i]C. elegans[/i]. / 09.02.2018 / PubMed / Full text

RHO

• Conditional reprogramming: next generation cell culture. / 08.2020 / PubMed / Full text
• SARS-CoV-2 receptor ACE2 and TMPRSS2 are primarily expressed in bronchial transient secretory cells. / 18.05.2020 / PubMed / Full text
• Redox Signaling of NADPH Oxidases Regulates Oxidative Stress Responses, Immunity and Aging. / 28.09.2018 / PubMed / Full text

ROCK1

• Disruption of both ROCK1 and ROCK2 genes in cardiomyocytes promotes autophagy and reduces cardiac fibrosis during aging. / 06.2019 / PubMed / Full text
• Sonic hedgehog regulation of cavernous nerve regeneration and neurite formation in aged pelvic plexus. / 02.2019 / PubMed / Full text
• Vascular Smooth Muscle Contractile Function Declines With Age in Skeletal Muscle Feed Arteries. / 2018 / PubMed / Full text

RUNX2

• Collaboration of MYC and RUNX2 in lymphoma simulates T-cell receptor signaling and attenuates p53 pathway activity. / 10.2019 / PubMed / Full text
• Chondrocyte-Specific RUNX2 Overexpression Accelerates Post-traumatic Osteoarthritis Progression in Adult Mice. / 09.2019 / PubMed / Full text
• microRNA-31 inhibition partially ameliorates the deficiency of bone marrow stromal cells from cleidocranial dysplasia. / 06.2019 / PubMed / Full text

S100A8

• S100A8, which increases with age, induces cellular senescence-like changes in bovine oviduct epithelial cells. / 09.2019 / PubMed / Full text
• Fetal articular cartilage regeneration versus adult fibrocartilaginous repair: secretome proteomics unravels molecular mechanisms in an ovine model. / 06.07.2018 / PubMed / Full text
• Lung cellular senescence is independent of aging in a mouse model of COPD/emphysema. / 13.06.2018 / PubMed / Full text

SCT

• Short-Term Training and Detraining Effects of Supervised vs. Unsupervised Resistance Exercise in Aging Adults. / 10.2019 / PubMed / Full text
• High-intensity interval training improves acute plasma volume responses to exercise that is age dependent. / 02.2018 / PubMed / Full text
• Communication technology adoption among older adult veterans: the interplay of social and cognitive factors. / 12.2018 / PubMed / Full text

SDC1

• Olmesartan alleviates bleomycin-mediated vascular smooth muscle cell senescence via the miR-665/SDC1 axis. / 2020 / PubMed / Full text
• Sulfated syndecan 1 is critical to preventing cellular senescence by modulating fibroblast growth factor receptor endocytosis. / 08.2020 / PubMed / Full text
• Alterations in Corneal Sensory Nerves During Homeostasis, Aging, and After Injury in Mice Lacking the Heparan Sulfate Proteoglycan Syndecan-1. / 01.10.2017 / PubMed / Full text

SERPINE1

• Elevated circulating HtrA4 in preeclampsia may alter endothelial expression of senescence genes. / 15.01.2020 / PubMed / Full text
• Human iPSC-derived MSCs (iMSCs) from aged individuals acquire a rejuvenation signature. / 18.03.2019 / PubMed / Full text
• A null mutation in [i]SERPINE1[/i] protects against biological aging in humans. / 11.2017 / PubMed / Full text

SHH

• Recent advances in SHH medulloblastoma progression: tumor suppressor mechanisms and the tumor microenvironment. / 2019 / PubMed / Full text
• An Endogenous Anti-aging Factor, Sonic Hedgehog, Suppresses Endometrial Stem Cell Aging through SERPINB2. / 03.07.2019 / PubMed / Full text
• Sonic hedgehog regulation of cavernous nerve regeneration and neurite formation in aged pelvic plexus. / 02.2019 / PubMed / Full text

SIRT5

• Lysine malonylation and propionylation are prevalent in human lens proteins. / 01.2020 / PubMed / Full text
• Analysis of Polymorphisms in 59 Potential Candidate Genes for Association With Human Longevity. / 08.10.2018 / PubMed / Full text
• Expression of Sirtuins in the Retinal Neurons of Mice, Rats, and Humans. / 2017 / PubMed / Full text

SLC6A4

• The Psilocybin-Telomere Hypothesis: An empirically falsifiable prediction concerning the beneficial neuropsychopharmacological effects of psilocybin on genetic aging. / 01.2020 / PubMed / Full text
• Epigenetics-by-sex interaction for somatization conferred by methylation at the promoter region of SLC6A4 gene. / 08.03.2019 / PubMed / Full text
• Proteomics and metabolomics identify molecular mechanisms of aging potentially predisposing for chronic lymphocytic leukemia. / 02.2018 / PubMed / Full text

SNAI1

• MicroRNA-338-5p plays a tumor suppressor role in glioma through inhibition of the MAPK-signaling pathway by binding to FOXD1. / 12.2018 / PubMed / Full text
• O-GlcNAcylation is required for mutant KRAS-induced lung tumorigenesis. / 01.11.2018 / PubMed / Full text
• Upregulation of lactate-inducible snail protein suppresses oncogene-mediated senescence through p16 inactivation. / 26.02.2018 / PubMed / Full text

SNAP25

• The Biological Foundations of Sarcopenia: Established and Promising Markers. / 2019 / PubMed / Full text
• Frontotemporal dysregulation of the SNARE protein interactome is associated with faster cognitive decline in old age. / 06.2018 / PubMed / Full text
• NUPR1 maintains autolysosomal efflux by activating SNAP25 transcription in cancer cells. / 2018 / PubMed / Full text

SOCS3

• Congenital Hypothyroidism is Associated With Impairment of the Leptin Signaling Pathway in the Hypothalamus in Male Wistar Animals in Adult Life. / 05.2019 / PubMed / Full text
• Deletion of suppressor of cytokine signaling 3 (SOCS3) in muscle stem cells does not alter muscle regeneration in mice after injury. / 2019 / PubMed / Full text
• Age-related remodeling of the JAK/STAT/SOCS signaling pathway and associated myocardial changes: From histological to molecular level. / 11.2017 / PubMed / Full text

SPRY1

• Sprouty1 Prevents Cellular Senescence Maintaining Proliferation and Differentiation Capacity of Human Adipose Stem/Progenitor Cells. / 13.11.2020 / PubMed / Full text
• Mechanism of SPRY1 methylation regulating natural aging of skin epidermal cells. / 05.2020 / PubMed / Full text
• MicroRNA-21 promotes glioma cell proliferation and inhibits senescence and apoptosis by targeting SPRY1 via the PTEN/PI3K/AKT signaling pathway. / 05.2018 / PubMed / Full text

SRC

• Metabolic characteristics of CD8 T cell subsets in young and aged individuals are not predictive of functionality. / 05.06.2020 / PubMed / Full text
• Overexpression of steroid receptor coactivators alleviates hyperglycemia-induced endothelial cell injury in rats through activating the PI3K/Akt pathway. / 05.2019 / PubMed / Full text
• Integrative Analysis of Hippocampus Gene Expression Profiles Identifies Network Alterations in Aging and Alzheimer's Disease. / 2018 / PubMed / Full text

SYK

• miR-25-3p promotes endothelial cell angiogenesis in aging mice via TULA-2/SYK/VEGFR-2 downregulation. / 17.11.2020 / PubMed / Full text
• Identification of SYK inhibitor, R406 as a novel senolytic agent. / 07.05.2020 / PubMed / Full text
• Integrative Analysis of Hippocampus Gene Expression Profiles Identifies Network Alterations in Aging and Alzheimer's Disease. / 2018 / PubMed / Full text

TET1

• Age-related Changes in the Global DNA Methylation Profile of Oligodendrocyte Progenitor Cells Derived from Rat Spinal Cords. / 02.2019 / PubMed / Full text
• Epigenetic Co-Deregulation of EZH2/TET1 is a Senescence-Countering, Actionable Vulnerability in Triple-Negative Breast Cancer. / 2019 / PubMed / Full text
• DNA Hydroxymethylation Levels Are Altered in Blood Cells From Down Syndrome Persons Enrolled in the MARK-AGE Project. / 09.05.2018 / PubMed / Full text

TLR1

• Effects of aging and lifelong aerobic exercise on expression of innate immune components in human skeletal muscle. / 01.12.2020 / PubMed / Full text
• Association of TLR gene variants in a Czech Red Pied cattle population with reproductive traits. / 02.2020 / PubMed / Full text
• Decreased NLRP3 inflammasome expression in aged lung may contribute to increased susceptibility to secondary Streptococcus pneumoniae infection. / 05.2018 / PubMed / Full text

TMEM106B

• Genetics of Gene Expression in the Aging Human Brain Reveal TDP-43 Proteinopathy Pathophysiology. / 05.08.2020 / PubMed / Full text
• TMEM106B, a risk factor for FTLD and aging, has an intrinsically disordered cytoplasmic domain. / 2018 / PubMed / Full text
• TMEM106B haplotypes have distinct gene expression patterns in aged brain. / 03.07.2018 / PubMed / Full text

TNC

• Effects of Tenascin C on the Integrity of Extracellular Matrix and Skin Aging. / 18.11.2020 / PubMed / Full text
• Tenascin-C expression controls the maturation of articular cartilage in mice. / 17.02.2020 / PubMed / Full text
• Effects of hydrothermal aging, thermal cycling, and water storage on the mechanical properties of a machinable resin-based composite containing nano-zirconia fillers. / 02.2020 / PubMed / Full text

TRA

• MYC Releases Early Reprogrammed Human Cells from Proliferation Pause via Retinoblastoma Protein Inhibition. / 10.04.2018 / PubMed / Full text
• Sex-specific regulation of aging in Caenorhabditis elegans. / 06.2018 / PubMed / Full text
• Age-Associated Decline in Thymic B Cell Expression of Aire and Aire-Dependent Self-Antigens. / 30.01.2018 / PubMed / Full text

TRAF3

• TRAF3, a Target of MicroRNA-363-3p, Suppresses Senescence and Regulates the Balance Between Osteoblastic and Adipocytic Differentiation of Rat Bone Marrow-Derived Mesenchymal Stem Cells. / 01.06.2020 / PubMed / Full text
• TGFβ-induced degradation of TRAF3 in mesenchymal progenitor cells causes age-related osteoporosis. / 26.06.2019 / PubMed / Full text
• Aging impairs both primary and secondary RIG-I signaling for interferon induction in human monocytes. / 12.12.2017 / PubMed / Full text

TRIM59

• DNA methylation of the ELOVL2, FHL2, KLF14, C1orf132/MIR29B2C, and TRIM59 genes for age prediction from blood, saliva, and buccal swab samples. / 01.2019 / PubMed / Full text
• Proof of concept study of age-dependent DNA methylation markers across different tissues by massive parallel sequencing. / 09.2018 / PubMed / Full text
• Chronological age prediction based on DNA methylation: Massive parallel sequencing and random forest regression. / 11.2017 / PubMed / Full text

TRPV1

• Reduced bladder responses to capsaicin and GSK-1016790A in retired-breeder female rats with diminished volume sensitivity. / 01.11.2018 / PubMed / Full text
• Expression of CGRP neurotransmitter and vascular genesis marker mRNA is age-dependent in superior cervical ganglia of senescence-accelerated prone mice. / 18.01.2018 / PubMed / Full text
• A comparative study on the therapeutic effect of TRPV1, TRPA1, and TRPM8 agonists on swallowing dysfunction associated with aging and neurological diseases. / 02.2018 / PubMed / Full text

TSC1

• mTORC1 underlies age-related muscle fiber damage and loss by inducing oxidative stress and catabolism. / 06.2019 / PubMed / Full text
• FTO is involved in Alzheimer's disease by targeting TSC1-mTOR-Tau signaling. / 25.03.2018 / PubMed / Full text
• Postnatal reduction of tuberous sclerosis complex 1 expression in astrocytes and neurons causes seizures in an age-dependent manner. / 12.2017 / PubMed / Full text

VDAC1

• Low abundance of NDUFV2 and NDUFS4 subunits of the hydrophilic complex I domain and VDAC1 predicts mammalian longevity. / 07.2020 / PubMed / Full text
• Changes in the expression of oxidative phosphorylation complexes in the aging intestinal mucosa. / 01.07.2020 / PubMed / Full text
• Cytosolic and mitochondrial Ca concentrations in primary hepatocytes change with ageing and in consequence of an mtDNA mutation. / 09.2019 / PubMed / Full text

VHL

• Hypoxic response regulators RHY-1 and EGL-9/PHD promote longevity through a VHL-1-independent transcriptional response. / 12.2020 / PubMed / Full text
• The Energy Maintenance Theory of Aging: Maintaining Energy Metabolism to Allow Longevity. / 08.2018 / PubMed / Full text
• Shorter telomere length increases age-related tumor risks in von Hippel-Lindau disease patients. / 09.2017 / PubMed / Full text

VIM

• Establishment and characterization of a fibroblast cell line from postmortem skin of an adult Chinese muntjac (Muntiacus reevesi). / 02.2020 / PubMed / Full text
• The effect of test modality on dynamic exercise biomarkers in children, adolescents, and young adults. / 07.2019 / PubMed / Full text
• Centenarians Overexpress Pluripotency-Related Genes. / 16.08.2019 / PubMed / Full text

VWF

• Von Willebrand disease in the elderly: clinical perspectives. / 2018 / PubMed / Full text
• Comorbidities associated with higher von Willebrand factor (VWF) levels may explain the age-related increase of VWF in von Willebrand disease. / 07.2018 / PubMed / Full text
• The Association of Aging With Von Willebrand Factor Levels and Bleeding Risk in Type 1 Von Willebrand Disease. / 04.2018 / PubMed / Full text

WNT1

• Plasma proteomic profile of age, health span, and all-cause mortality in older adults. / 11.2020 / PubMed / Full text
• Aging Disrupts Muscle Stem Cell Function by Impairing Matricellular WISP1 Secretion from Fibro-Adipogenic Progenitors. / 07.03.2019 / PubMed / Full text
• Wnt1 is an Lrp5-independent bone-anabolic Wnt ligand. / 07.11.2018 / PubMed / Full text

WNT3A

• Chronic WNT/β-catenin signaling induces cellular senescence in lung epithelial cells. / 06.2020 / PubMed / Full text
• WNT3A accelerates delayed alveolar bone repair in ovariectomized mice. / 09.2019 / PubMed / Full text
• WNT-activated bone grafts repair osteonecrotic lesions in aged animals. / 27.10.2017 / PubMed / Full text

XIAP

• Directed elimination of senescent cells attenuates development of osteoarthritis by inhibition of c-IAP and XIAP. / 01.10.2019 / PubMed / Full text
• Modulated electro-hyperthermia induced p53 driven apoptosis and cell cycle arrest additively support doxorubicin chemotherapy of colorectal cancer in vitro. / 08.2019 / PubMed / Full text
• Protective effect of xanthohumol against age-related brain damage. / 11.2017 / PubMed / Full text

XPA

• Analysis of somatic mutations identifies signs of selection during in vitro aging of primary dermal fibroblasts. / 12.2019 / PubMed / Full text
• Proteomics and metabolomics identify molecular mechanisms of aging potentially predisposing for chronic lymphocytic leukemia. / 02.2018 / PubMed / Full text
• Systematic analysis of DNA crosslink repair pathways during development and aging in Caenorhabditis elegans. / 19.09.2017 / PubMed / Full text