Aging genes 30-59

STAT3Править

Dietary Restriction Suppresses Steatosis-Associated Hepatic Tumorigenesis in Hepatitis C Virus Core Gene Transgenic Mice. / 09.2020 / PubMed / Full text
Skeletal glucocorticoid signalling determines leptin resistance and obesity in aging mice. / 12.2020 / PubMed / Full text
AMPK alleviates oxidative stress‑induced premature senescence via inhibition of NF-κB/STAT3 axis-mediated positive feedback loop. / 10.2020 / PubMed / Full text
Age-related loss of neural stem cell O-GlcNAc promotes a glial fate switch through STAT3 activation. / 08.09.2020 / PubMed / Full text
Cell Death by Gallotannin Is Associated with Inhibition of the JAK/STAT Pathway in Human Colon Cancer Cells. / 2020 / PubMed / Full text
The effect of interleukin 6 deficiency on myocardial signal transduction pathways activation induced by bacterial lipopolysaccharide in young and old mice. / 09.2020 / PubMed / Full text
Silibinin and SARS-CoV-2: Dual Targeting of Host Cytokine Storm and Virus Replication Machinery for Clinical Management of COVID-19 Patients. / 07.06.2020 / PubMed / Full text
Implication of JAK1/STAT3/SOCS3 Pathway in Aging of Cerebellum of Male Rat: Histological and Molecular study. / 01.06.2020 / PubMed / Full text
Atorvastatin-induced senescence of hepatocellular carcinoma is mediated by downregulation of hTERT through the suppression of the IL-6/STAT3 pathway. / 2020 / PubMed / Full text
Deciphering the Molecular Mechanism of Spontaneous Senescence in Primary Epithelial Ovarian Cancer Cells. / 27.01.2020 / PubMed / Full text
Persistent Activation of STAT3 Pathway in the Retina Induced Vision Impairment and Retinal Degenerative Changes in Ageing Mice. / 2019 / PubMed / Full text
Interleukin-10 induces senescence of activated hepatic stellate cells via STAT3-p53 pathway to attenuate liver fibrosis. / 02.2020 / PubMed / Full text
The proteasome activator REGγ counteracts immunoproteasome expression and autoimmunity. / 09.2019 / PubMed / Full text
Sexual dimorphism in rat thymic involution: a correlation with thymic oxidative status and inflammation. / 08.2019 / PubMed / Full text
Inflammaging: Age and Systemic, Cellular, and Nuclear Inflammatory Biology in Older Adults. / 04.10.2019 / PubMed / Full text
A novel STAT3 inhibitor, HJC0152, exerts potent antitumor activity in glioblastoma. / 2019 / PubMed / Full text
Congenital Hypothyroidism is Associated With Impairment of the Leptin Signaling Pathway in the Hypothalamus in Male Wistar Animals in Adult Life. / 05.2019 / PubMed / Full text
mTORC1 underlies age-related muscle fiber damage and loss by inducing oxidative stress and catabolism. / 06.2019 / PubMed / Full text
[Tea polyphenols delays human glomerular mesangial cells senescence induced by high glucose via regulating STAT3/miR-126/telomere signaling pathway activation]. / 12.2018 / PubMed / Full text
STAT3 Regulates the Onset of Oxidant-induced Senescence in Lung Fibroblasts. / 07.2019 / PubMed / Full text
Deciphering Molecular and Phenotypic Changes Associated with Early Autoimmune Disease in the Aire-Deficient Mouse Model of Sjögren's Syndrome. / 17.11.2018 / PubMed / Full text
Senescent Breast Luminal Cells Promote Carcinogenesis through Interleukin-8-Dependent Activation of Stromal Fibroblasts. / 15.01.2019 / PubMed / Full text
The role of STAT3/mTOR-regulated autophagy in angiotensin II-induced senescence of human glomerular mesangial cells. / 01.2019 / PubMed / Full text
A Novel [i]Dnmt3a1[/i] Transcript Inhibits Adipogenesis. / 2018 / PubMed / Full text
Targeting a phospho-STAT3-miRNAs pathway improves vesicular hepatic steatosis in an in vitro and in vivo model. / 11.09.2018 / PubMed / Full text
Decreased NAD Activates STAT3 and Integrin Pathways to Drive Epithelial-Mesenchymal Transition. / 10.2018 / PubMed / Full text
Integrative Analysis of Hippocampus Gene Expression Profiles Identifies Network Alterations in Aging and Alzheimer's Disease. / 2018 / PubMed / Full text
Overexpression of Klotho Inhibits HELF Fibroblasts SASP-related Protumoral Effects on Non-small Cell Lung Cancer Cells. / 2018 / PubMed / Full text
Fibroblast senescence in the pathology of idiopathic pulmonary fibrosis. / 01.08.2018 / PubMed / Full text
Age-Associated Differences in Infection of Human Skin in the SCID Mouse Model of Varicella-Zoster Virus Pathogenesis. / 01.06.2018 / PubMed / Full text
MMP2-A2M interaction increases ECM accumulation in aged rat kidney and its modulation by calorie restriction. / 19.01.2018 / PubMed / Full text
Deficiency in Protein Tyrosine Phosphatase PTP1B Shortens Lifespan and Leads to Development of Acute Leukemia. / 01.01.2018 / PubMed / Full text
Chronic disruptions of circadian sleep regulation induce specific proinflammatory responses in the rat colon. / 2017 / PubMed / Full text
Genome-wide association study and annotating candidate gene networks affecting age at first calving in Nellore cattle. / 12.2017 / PubMed / Full text
The pathological roles of NDRG2 in Alzheimer's disease, a study using animal models and APPwt-overexpressed cells. / 08.2017 / PubMed / Full text
Maintenance of membrane organization in the aging mouse brain as the determining factor for preventing receptor dysfunction and for improving response to anti-Alzheimer treatments. / 06.2017 / PubMed / Full text
JAK-STAT signaling mediates the senescence of bone marrow-mesenchymal stem cells from systemic lupus erythematosus patients. / 01.03.2017 / PubMed / Full text
Hypothalamic S1P/S1PR1 axis controls energy homeostasis in Middle-Aged Rodents: the reversal effects of physical exercise. / 26.12.2016 / PubMed / Full text
Intracerebroventricular tempol administration in older rats reduces oxidative stress in the hypothalamus but does not change STAT3 signalling or SIRT1/AMPK pathway. / 01.2017 / PubMed / Full text
STAT3-mediated SMAD3 activation underlies Oncostatin M-induced Senescence. / 16.02.2017 / PubMed / Full text
Impaired Epidermal to Dendritic T Cell Signaling Slows Wound Repair in Aged Skin. / 17.11.2016 / PubMed / Full text
Aging amplifies multiple phenotypic defects in mice with zinc transporter Zip14 (Slc39a14) deletion. / 01.12.2016 / PubMed / Full text
The role of STAT transcription factors in apoptosis regulation of hypothalamic neurons in aging in HER-2/neu transgenic mice and wild-type FVB/N mice. / 05.2016 / PubMed / Full text
Exogenous H2S contributes to recovery of ischemic post-conditioning-induced cardioprotection by decrease of ROS level via down-regulation of NF-κB and JAK2-STAT3 pathways in the aging cardiomyocytes. / 2016 / PubMed / Full text
Enhanced Transcriptional Activity and Mitochondrial Localization of STAT3 Co-induce Axon Regrowth in the Adult Central Nervous System. / 12.04.2016 / PubMed / Full text
The Inflammatory Transcription Factors NFκB, STAT1 and STAT3 Drive Age-Associated Transcriptional Changes in the Human Kidney. / 12.2015 / PubMed / Full text
[Epidermal aging and anti-aging strategies]. / 02.2016 / PubMed / Full text
Seipin knockout in mice impairs stem cell proliferation and progenitor cell differentiation in the adult hippocampal dentate gyrus via reduced levels of PPARγ. / 12.2015 / PubMed / Full text
IL10-driven STAT3 signalling in senescent macrophages promotes pathological eye angiogenesis. / 11.08.2015 / PubMed / Full text
Down-regulation of mir-542-3p promotes neointimal formation in the aging rat. / 09.2015 / PubMed / Full text
CD4⁺CD28null T lymphocytes resemble CD8⁺CD28null T lymphocytes in their responses to IL-15 and IL-21 in HIV-infected patients. / 09.2015 / PubMed / Full text
Constitutive STAT3 activation in epidermal keratinocytes enhances cell clonogenicity and favours spontaneous immortalization by opposing differentiation and senescence checkpoints. / 01.2015 / PubMed / Full text
STAT3 signaling controls satellite cell expansion and skeletal muscle repair. / 10.2014 / PubMed / Full text
Aging impairs transcriptional regulation of vascular endothelial growth factor in human microvascular endothelial cells: implications for angiogenesis and cell survival. / 04.2014 / PubMed
Gene expression profiling of Epstein-Barr virus-positive diffuse large B-cell lymphoma of the elderly reveals alterations of characteristic oncogenetic pathways. / 05.2014 / PubMed / Full text
STAT3 and metabolism: how many ways to use a single molecule? / 01.11.2014 / PubMed / Full text
Differential loss of prolyl isomerase or chaperone activity of Ran-binding protein 2 (Ranbp2) unveils distinct physiological roles of its cyclophilin domain in proteostasis. / 21.02.2014 / PubMed / Full text
IL-6-STAT3 signaling and premature senescence. / 01.10.2013 / PubMed / Full text
From cirrhosis to hepatocellular carcinoma: new molecular insights on inflammation and cellular senescence. / 08.2013 / PubMed / Full text

GDF11Править

Growth differentiation factor-11 supplementation improves survival and promotes recovery after ischemic stroke in aged mice. / 04.05.2020 / PubMed / Full text
Anti-Aging Effects of GDF11 on Skin. / 09.04.2020 / PubMed / Full text
Targeted Approach to Distinguish and Determine Absolute Levels of GDF8 and GDF11 in Mouse Serum. / 06.2020 / PubMed / Full text
Growth differentiation factor 11 impairs titanium implant healing in the femur and leads to mandibular bone loss. / 09.2020 / PubMed / Full text
Systemic GDF11 stimulates the secretion of adiponectin and induces a calorie restriction-like phenotype in aged mice. / 01.2020 / PubMed / Full text
Circulating factors in young blood as potential therapeutic agents for age-related neurodegenerative and neurovascular diseases. / 11.2019 / PubMed / Full text
Effects of Exercise Training on Growth and Differentiation Factor 11 Expression in Aged Mice. / 2019 / PubMed / Full text
TERT assists GDF11 to rejuvenate senescent VEGFR2 /CD133 cells in elderly patients with myocardial infarction. / 11.2019 / PubMed / Full text
The role of GDF11 in aging and skeletal muscle, cardiac and bone homeostasis. / 04.2019 / PubMed / Full text
Circulating GDF11 levels are decreased with age but are unchanged with obesity and type 2 diabetes. / 21.03.2019 / PubMed / Full text
Activin type II receptor signaling in cardiac aging and heart failure. / 06.03.2019 / PubMed / Full text
Neuroprotective potential of GDF11 in experimental intracerebral hemorrhage in elderly rats. / 05.2019 / PubMed / Full text
The influence of GDF11 on brain fate and function. / 02.2019 / PubMed / Full text
Administration of rGDF11 retards the aging process in male mice via action of anti-oxidant system. / 08.2019 / PubMed / Full text
Novel biomolecules of ageing, sex differences and potential underlying mechanisms of telomere shortening in coronary artery disease. / 05.2019 / PubMed / Full text
The Growth Differentiation Factor 11 is Involved in Skin Fibroblast Ageing and is Induced by a Preparation of Peptides and Sugars Derived from Plant Cell Cultures. / 03.2019 / PubMed / Full text
[The role of «Youth and aging proteins» in essential hypertension pathogenesis.] / 2018 / PubMed
Regenerative Capacity of Endogenous Factor: Growth Differentiation Factor 11; a New Approach of the Management of Age-Related Cardiovascular Events. / 12.12.2018 / PubMed / Full text
Late-onset administration of GDF11 extends life span and delays development of age-related markers in the annual fish Nothobranchius guentheri. / 04.2019 / PubMed / Full text
Growth Differentiation Factor 11 treatment leads to neuronal and vascular improvements in the hippocampus of aged mice. / 23.11.2018 / PubMed / Full text
Relationship of Circulating Growth and Differentiation Factors 8 and 11 and Their Antagonists as Measured Using Liquid Chromatography-Tandem Mass Spectrometry With Age and Skeletal Muscle Strength in Healthy Adults. / 01.01.2019 / PubMed / Full text
The GDF11-FTO-PPARγ axis controls the shift of osteoporotic MSC fate to adipocyte and inhibits bone formation during osteoporosis. / 12.2018 / PubMed / Full text
The effects of aging, diabetes mellitus, and antiplatelet drugs on growth factors and anti-aging proteins in platelet-rich plasma. / 2019 / PubMed / Full text
Relationship of muscle function to circulating myostatin, follistatin and GDF11 in older women and men. / 30.08.2018 / PubMed / Full text
Activin subfamily peptides predict chronological age in humans. / 09.2018 / PubMed / Full text
Growth differentiation factor 11 worsens hepatocellular injury and liver regeneration after liver ischemia reperfusion injury. / 09.2018 / PubMed / Full text
The [i]Drosophila[/i] TGF-beta/Activin-like ligands Dawdle and Myoglianin appear to modulate adult lifespan through regulation of 26S proteasome function in adult muscle. / 26.04.2018 / PubMed / Full text
Lifelong exercise, but not short-term high-intensity interval training, increases GDF11, a marker of successful aging: a preliminary investigation. / 07.2017 / PubMed / Full text
Exogenous GDF11 induces cardiac and skeletal muscle dysfunction and wasting. / 07.2017 / PubMed / Full text
["Protein of senility" CCL11, "protein of juvenility" GDF11 and their role in age-related pathology]. / 2016 / PubMed
A targeted proteomic assay for the measurement of plasma proteoforms related to human aging phenotypes. / 08.2017 / PubMed / Full text
The Growth Differentiation Factor 11 (GDF11) and Myostatin (MSTN) in tissue specific aging. / 06.2017 / PubMed / Full text
Targeted myocardial delivery of GDF11 gene rejuvenates the aged mouse heart and enhances myocardial regeneration after ischemia-reperfusion injury. / 01.2017 / PubMed / Full text
GDF11 Treatment Attenuates the Recovery of Skeletal Muscle Function After Injury in Older Rats. / 03.2017 / PubMed / Full text
GDF11 improves tubular regeneration after acute kidney injury in elderly mice. / 05.10.2016 / PubMed / Full text
Increased serum GDF11 concentration is associated with a high prevalence of osteoporosis in elderly native Chinese women. / 11.2016 / PubMed / Full text
GDF11 administration does not extend lifespan in a mouse model of premature aging. / 30.08.2016 / PubMed / Full text
GDF11 Inhibits Bone Formation by Activating Smad2/3 in Bone Marrow Mesenchymal Stem Cells. / 11.2016 / PubMed / Full text
Serum Levels of Growth Differentiation Factor 11 Are Independently Associated with Low Hemoglobin Values in Hemodialysis Patients. / 2016 / PubMed / Full text
Quantification of GDF11 and Myostatin in Human Aging and Cardiovascular Disease. / 14.06.2016 / PubMed / Full text
Lack of evidence for GDF11 as a rejuvenator of aged skeletal muscle satellite cells. / 06.2016 / PubMed / Full text
Is Growth Differentiation Factor 11 a Realistic Therapeutic for Aging-Dependent Muscle Defects? / 01.04.2016 / PubMed / Full text
Biochemistry and Biology of GDF11 and Myostatin: Similarities, Differences, and Questions for Future Investigation. / 01.04.2016 / PubMed / Full text
Circulating Concentrations of Growth Differentiation Factor 11 Are Heritable and Correlate With Life Span. / 12.2016 / PubMed / Full text
Evaluation of growth differentiation factor 11 (GDF11) levels in dogs with chronic mitral valve insufficiency. / 01.2016 / PubMed / Full text
Molecular mechanism of endothelial and vascular aging: implications for cardiovascular disease. / 21.12.2015 / PubMed / Full text
Circulating Growth Differentiation Factor 11/8 Levels Decline With Age. / 08.01.2016 / PubMed / Full text
GDF11 does not rescue aging-related pathological hypertrophy. / 06.11.2015 / PubMed / Full text
Splenocytes derived from young WT mice prevent AD progression in APPswe/PSENldE9 transgenic mice. / 28.08.2015 / PubMed / Full text
Blood-Borne Revitalization of the Aged Brain. / 10.2015 / PubMed / Full text
GDF11 Increases with Age and Inhibits Skeletal Muscle Regeneration. / 07.07.2015 / PubMed / Full text
The aging human recipient of transfusion products. / 06.2015 / PubMed / Full text
Systemic factors mediate reversible age-associated brain dysfunction. / 12.2014 / PubMed / Full text
Rejuvenation: it's in our blood. / 01.07.2014 / PubMed / Full text
Intertissue control of the nucleolus via a myokine-dependent longevity pathway. / 12.06.2014 / PubMed / Full text
Vascular and neurogenic rejuvenation of the aging mouse brain by young systemic factors. / 09.05.2014 / PubMed / Full text
Restoring systemic GDF11 levels reverses age-related dysfunction in mouse skeletal muscle. / 09.05.2014 / PubMed / Full text

SHBGПравить

Endogenous Testosterone Levels and the Risk of Incident Cardiovascular Events in Elderly Men: The MrOS Prospective Study. / 01.05.2020 / PubMed / Full text
Associations of Endogenous Sex Hormones with Carotid Plaque Burden and Characteristics in Midlife Women. / 01.04.2020 / PubMed / Full text
Analysis of the Relationship between the Levels of Androgens and Biochemical Bone Markers in Men Aged 60-75 Years. / 22.12.2019 / PubMed / Full text
Testosterone and Estrone Increase From the Age of 70 Years: Findings From the Sex Hormones in Older Women Study. / 01.12.2019 / PubMed / Full text
Aging and the Male Reproductive System. / 01.08.2019 / PubMed / Full text
Prospective associations of androgens and sex hormone-binding globulin with 12-month, lifetime and incident anxiety and depressive disorders in men and women from the general population. / 15.02.2019 / PubMed / Full text
Cross-sectional associations of sex hormones with leucocyte telomere length, a marker of biological age, in a community-based cohort of older men. / 04.2019 / PubMed / Full text
Testosterone level in aging male with different glucose tolerance state and its association with osteocalcin. / 03.2019 / PubMed / Full text
Inverse association of testosterone and sex hormone binding globulin levels with leukocyte count in middle-aged and elderly men. / 09.2018 / PubMed / Full text
[Vasectomy has no obvious longterm influence on the levels of serum androgens in aging males]. / 02.2017 / PubMed
GONADOPENIA AND AGING IN MEN. / 04.2018 / PubMed / Full text
Reassessing Free-Testosterone Calculation by Liquid Chromatography-Tandem Mass Spectrometry Direct Equilibrium Dialysis. / 01.06.2018 / PubMed / Full text
Plasma steroids, body composition, and fat distribution: effects of age, sex, and exercise training. / 07.2018 / PubMed / Full text
New determinants for gallstone disease? . / 02.2018 / PubMed
The effect of acute and chronic exercise on steroid hormone fluctuations in young and middle-aged men. / 04.2018 / PubMed / Full text
Effects of growth hormone administration on luteinizing hormone secretion in healthy older men and women. / 12.2017 / PubMed / Full text
Individual testosterone decline and future mortality risk in men. / 01.2018 / PubMed / Full text
Ageratum conyzoides L. inhibits 5-alpha-reductase gene expression in human prostate cells and reduces symptoms of benign prostatic hypertrophy in otherwise healthy men in a double blind randomized placebo controlled clinical study. / 11.2017 / PubMed / Full text
Evaluating Calculated Free Testosterone as a Predictor of Morbidity and Mortality Independent of Testosterone for Cross-sectional and 5-Year Longitudinal Health Outcomes in Older Men: The Concord Health and Ageing in Men Project. / 09.05.2018 / PubMed / Full text
Progressive impairment of testicular endocrine function in ageing men: Testosterone and dihydrotestosterone decrease, and luteinizing hormone increases, in men transitioning from the 8th to 9th decades of life. / 01.2018 / PubMed / Full text
The impact of age, BMI and sex hormone on aging males' symptoms and the international index of erectile function scores. / 12.2017 / PubMed / Full text
Serum Concentrations of Sex Hormone-binding Globulin Vary Widely in Younger and Older Men: Clinical Data from a Men's Health Practice. / 03.2019 / PubMed / Full text
Are incident gallstones associated to sex-dependent changes with age? A cohort study. / 09.2017 / PubMed / Full text
Relationships between [i]FTO[/i] rs9939609, [i]MC4R[/i] rs17782313, and [i]PPARγ[/i] rs1801282 polymorphisms and the occurrence of selected metabolic and hormonal disorders in middle-aged and elderly men - a preliminary study. / 2016 / PubMed / Full text
Lipid Accumulation Product (LAP) as an Index of Metabolic and Hormonal Disorders in Aging Men. / 03.2017 / PubMed / Full text
The Limited Clinical Utility of Testosterone, Estradiol, and Sex Hormone Binding Globulin Measurements in the Prediction of Fracture Risk and Bone Loss in Older Men. / 03.2017 / PubMed / Full text
Progressive Temporal Change in Serum SHBG, But Not in Serum Testosterone or Estradiol, Is Associated With Bone Loss and Incident Fractures in Older Men: The Concord Health and Ageing in Men Project. / 12.2016 / PubMed / Full text
SHBG, Sex Steroids, and Kyphosis in Older Men: The MrOS Study. / 12.2016 / PubMed / Full text
Testosterone and disinhibited personality in healthy males. / 01.10.2016 / PubMed / Full text
The reproductive health indices and sex hormone levels in middle-aged and elderly Chinese men. / 09.2016 / PubMed / Full text
Hypothalamic-Pituitary-Gonadal Axis in Aging Men and Women: Increasing Total Testosterone in Aging Men. / 2017 / PubMed / Full text
Temporal Changes in Androgens and Estrogens Are Associated With All-Cause and Cause-Specific Mortality in Older Men. / 05.2016 / PubMed / Full text
Circulating Sex Steroids and Vascular Calcification in Community-Dwelling Men: The Framingham Heart Study. / 05.2016 / PubMed / Full text
Bioavailable Testosterone Linearly Declines Over A Wide Age Spectrum in Men and Women From The Baltimore Longitudinal Study of Aging. / 09.2016 / PubMed / Full text
Temporal Trend in Androgen Status and Androgen-Sensitive Outcomes in Older Men. / 04.2016 / PubMed / Full text
The reciprocal links between synaptophysin serum levels and the prevalence of metabolic syndrome according to selected low-grade inflammation indices and age-related androgen serum level changes in men. / 01.2016 / PubMed
Relationship between Lipids Levels of Serum and Seminal Plasma and Semen Parameters in 631 Chinese Subfertile Men. / 2016 / PubMed / Full text
The Association of Reproductive Hormone Levels and All-Cause, Cancer, and Cardiovascular Disease Mortality in Men. / 12.2015 / PubMed / Full text
Dynamic alteration of serum testosterone with aging: a cross-sectional study from Shanghai, China. / 30.09.2015 / PubMed / Full text
Analysis of the relationship between the blood concentration of several metals, macro- and micronutrients and endocrine disorders associated with male aging. / 06.2016 / PubMed / Full text
Relative importance of AMH and androgens changes with aging among non-obese women with polycystic ovary syndrome. / 09.07.2015 / PubMed / Full text
Six weeks of conditioning exercise increases total, but not free testosterone in lifelong sedentary aging men. / 2015 / PubMed / Full text
Age-dependent sex hormone-binding globulin expression in male rat. / 04.2015 / PubMed / Full text
Longitudinal Relationships between Reproductive Hormones and Cognitive Decline in Older Men: The Concord Health and Ageing in Men Project. / 06.2015 / PubMed / Full text
The association of obesity with sex hormone-binding globulin is stronger than the association with ageing--implications for the interpretation of total testosterone measurements. / 12.2015 / PubMed / Full text
Reproductive Hormones and Longitudinal Change in Bone Mineral Density and Incident Fracture Risk in Older Men: The Concord Health and Aging in Men Project. / 09.2015 / PubMed / Full text
Associations between sex steroids and the development of metabolic syndrome: a longitudinal study in European men. / 04.2015 / PubMed / Full text
Resting steroid hormone concentrations in lifetime exercisers and lifetime sedentary males. / 03.2015 / PubMed / Full text
Total testosterone is the most valuable indicator of metabolic syndrome among various testosterone values in middle-aged Japanese men. / 2015 / PubMed / Full text
Free and bioavailable fractions of sex steroids may influence bones in young men, depending on age and oestradiol level. / 2014 / PubMed / Full text
Associations between circulating reproductive hormones and SHBG and prevalent and incident metabolic syndrome in community-dwelling older men: the Concord Health and Ageing in Men Project. / 12.2014 / PubMed / Full text
[Reproductive hormone levels and relevant parameters in middle-aged and older men in the urban area of Nanjing]. / 04.2014 / PubMed
[Correlation of sex hormones and parathyroid hormone with biochemical markers of bone turnover in aged men]. / 03.2014 / PubMed
Metabolic and hormonal contributors to survival in the participants of the Mataró Ageing Study at 8 years follow-up. / 11.2014 / PubMed / Full text
Longitudinal relationships of circulating reproductive hormone with functional disability, muscle mass, and strength in community-dwelling older men: the Concord Health and Ageing in Men project. / 09.2014 / PubMed / Full text
Longitudinal and cross-sectional relationships of circulating reproductive hormone levels to self-rated health and health-related quality of life in community-dwelling older men. / 05.2014 / PubMed / Full text

C2Править

[Effects of resistance training on mitochondrial function in skeletal muscle of aging rats]. / 03.2020 / PubMed / Full text
Structural and functional characterization of Solanum lycopersicum phosphatidylinositol 3-kinase C2 domain. / 03.2020 / PubMed / Full text
Radiological and Clinical Outcomes of Anterior Cervical Discectomy and Fusion in Older Patients: A Comparative Analysis of Young-Old Patients (Ages 65-74 Years) and Middle-Old Patients (Over 75 Years). / 03.2020 / PubMed / Full text
SerThr-PhosphoProteome of Brain from Aged PINK1-KO A53T-SNCA Mice Reveals pT1928-MAP1B and pS3781-ANK2 Deficits, as Hub between Autophagy and Synapse Changes. / 04.07.2019 / PubMed / Full text
Age-related Changes in Cervical Sagittal Alignment: A Radiographic Analysis. / 01.10.2019 / PubMed / Full text
Age and Sex-Associated Changes of Complement Activity and Complement Levels in a Healthy Caucasian Population. / 2018 / PubMed / Full text
Twenty-year Longitudinal Follow-up MRI Study of Asymptomatic Volunteers: The Impact of Cervical Alignment on Disk Degeneration. / 12.2018 / PubMed / Full text
Dialdehyde cellulose crosslinked poly(vinyl alcohol) hydrogels: Influence of catalyst and crosslinker shelf life. / 15.10.2018 / PubMed / Full text
Trend-analysis of dental hard-tissue conditions as function of tooth age. / 07.2018 / PubMed / Full text
Attenuation of the Niemann-Pick type C2 disease phenotype by intracisternal administration of an AAVrh.10 vector expressing Npc2. / 08.2018 / PubMed / Full text
Repurposing existing drugs for new AMPK activators as a strategy to extend lifespan: a computer-aided drug discovery study. / 04.2018 / PubMed / Full text
The change of cervical spine alignment along with aging in asymptomatic population: a preliminary analysis. / 09.2017 / PubMed / Full text
The changing shape of the ISCEV standard pattern onset VEP. / 08.2017 / PubMed / Full text
Three types of sagittal alignment regarding compensation in asymptomatic adults: the contribution of the spine and lower limbs. / 02.2018 / PubMed / Full text
C1 Complex: An Adaptable Proteolytic Module for Complement and Non-Complement Functions. / 2017 / PubMed / Full text
Age-related variations in global spinal alignment and sagittal balance in asymptomatic Japanese adults. / 05.2017 / PubMed / Full text
Fascin2 regulates cisplatin-induced apoptosis in NRK-52E cells. / 15.01.2017 / PubMed / Full text
Management of Type II Odontoid Fractures: Experience from Latin American Spine Centers. / 02.2017 / PubMed / Full text
An Evaluation of Functional Sit-to-Stand Power in Cohorts of Healthy Adults Aged 18-97 Years. / 04.2017 / PubMed / Full text
Population-Stratified Analysis of Bone Mineral Density Distribution in Cervical and Lumbar Vertebrae of Chinese from Quantitative Computed Tomography. / 09-10.2016 / PubMed / Full text
Posterior Fixation with C1 Lateral Mass Screws and C2 Pars Screws for Type II Odontoid Fracture in the Elderly: Long-Term Follow-Up. / 12.2016 / PubMed / Full text
A Large Cohort Study of 18F Fluoro-Deoxy-Glucose Uptake in Normal Spinal Cord: Quantitative Assessment of the Contamination From Adjacent Vertebral Marrow Uptake and Validity of Normalizing the Cord Uptake Against the Lumbar Thecal Sac. / 01.2017 / PubMed / Full text
Tumor growth accelerated by chemotherapy-induced senescent cells is suppressed by treatment with IL-12 producing cellular vaccines. / 23.08.2016 / PubMed / Full text
Genetic factors associated with the development of age-related macular degeneration. / 2016 / PubMed / Full text
Quantification of age-related changes of α-tocopherol in lysosomal membranes in murine tissues and human fibroblasts. / 05.2016 / PubMed / Full text
Variations in Occipitocervical and Cervicothoracic Alignment Parameters Based on Age: A Prospective Study of Asymptomatic Volunteers Using Full-Body Radiographs. / 01.12.2016 / PubMed / Full text
Tract-specific and age-related variations of the spinal cord microstructure: a multi-parametric MRI study using diffusion tensor imaging (DTI) and inhomogeneous magnetization transfer (ihMT). / 06.2016 / PubMed / Full text
Age-related brain atrophy may be mitigated by internal jugular vein enlargement in male individuals without neurologic disease. / 03.2017 / PubMed / Full text
C2-substituted aromatic cytokinin sugar conjugates delay the onset of senescence by maintaining the activity of the photosynthetic apparatus. / 02.2016 / PubMed / Full text
Empirically Defining Trajectories of Late-Life Cognitive and Functional Decline. / 2016 / PubMed / Full text
Age-Related and Degenerative Changes in the Osseous Anatomy, Alignment, and Range of Motion of the Cervical Spine: A Comparative Study of Radiographic Data From 1016 Patients With Cervical Spondylotic Myelopathy and 1230 Asymptomatic Subjects. / 03.2016 / PubMed / Full text
Prediction of Neurological Impairment in Cervical Spondylotic Myelopathy using a Combination of Diffusion MRI and Proton MR Spectroscopy. / 2015 / PubMed / Full text
Two-piece zirconia oral implants withstand masticatory loads: An investigation in the artificial mouth. / 01.2016 / PubMed / Full text
Six-year incidence of visually significant age-related cataract: the Chennai eye disease incidence study. / 03.2016 / PubMed / Full text
Are the standard parameters of cervical spine alignment and range of motion related to age, sex, and cervical disc degeneration? / 09.2015 / PubMed / Full text
The ossification pattern in paediatric occipito-cervical spine: is it possible to estimate real age? / 08.2015 / PubMed / Full text
The hyperornithinemia-hyperammonemia-homocitrullinuria syndrome. / 11.03.2015 / PubMed / Full text
Longevity and skeletal muscle mass: the role of IGF signalling, the sirtuins, dietary restriction and protein intake. / 08.2015 / PubMed / Full text
The role of TORC1 in muscle development in Drosophila. / 13.04.2015 / PubMed / Full text
XRCC1 and XPD genetic polymorphisms and susceptibility to age-related cataract: a meta-analysis. / 2015 / PubMed / Full text
Telomere dysfunction causes alveolar stem cell failure. / 21.04.2015 / PubMed / Full text
Comprehensive analysis of the ubiquitinome during oncogene-induced senescence in human fibroblasts. / 2015 / PubMed / Full text
mTOR signaling in aging and neurodegeneration: At the crossroad between metabolism dysfunction and impairment of autophagy. / 12.2015 / PubMed / Full text
Non-sirtuin histone deacetylases in the control of cardiac aging. / 06.2015 / PubMed / Full text
Senescence-inducible LEC2 enhances triacylglycerol accumulation in leaves without negatively affecting plant growth. / 12.2015 / PubMed / Full text
Age-Related Changes in Pharyngeal Lumen Size: A Retrospective MRI Analysis. / 06.2015 / PubMed / Full text
Loss of Extended Synaptotagmins ESyt2 and ESyt3 does not affect mouse development or viability, but in vitro cell migration and survival under stress are affected. / 2014 / PubMed / Full text
Diurnal and temporal variations of water-soluble dicarboxylic acids and related compounds in aerosols from the northern vicinity of Beijing: implication for photochemical aging during atmospheric transport. / 15.11.2014 / PubMed / Full text
Loss of α(E)-catenin potentiates cisplatin-induced nephrotoxicity via increasing apoptosis in renal tubular epithelial cells. / 09.2014 / PubMed / Full text
A role for the age-dependent loss of α(E)-catenin in regulation of N-cadherin expression and cell migration. / 01.06.2014 / PubMed / Full text
Spontaneous age-related cervical disc degeneration in the sand rat. / 06.2014 / PubMed / Full text

FOXO3Править

The DNA methylation of FOXO3 and TP53 as a blood biomarker of late-onset asthma. / 09.12.2020 / PubMed / Full text
FOXO3 targets are reprogrammed as Huntington's disease neural cells and striatal neurons face senescence with p16 increase. / 11.2020 / PubMed / Full text
Astaxanthin as a Putative Geroprotector: Molecular Basis and Focus on Brain Aging. / 05.07.2020 / PubMed / Full text
Inflamma-miR-21 Negatively Regulates Myogenesis during Ageing. / 23.04.2020 / PubMed / Full text
Variable DNA methylation of aging-related genes is associated with male COPD. / 04.11.2019 / PubMed / Full text
A conserved role of the insulin-like signaling pathway in diet-dependent uric acid pathologies in Drosophila melanogaster. / 08.2019 / PubMed / Full text
FOXO3 on the Road to Longevity: Lessons From SNPs and Chromatin Hubs. / 2019 / PubMed / Full text
Longevity-Associated Forkhead Box O3 (FOXO3) Single Nucleotide Polymorphisms are Associated with Type 2 Diabetes Mellitus in Chinese Elderly Women. / 22.04.2019 / PubMed / Full text
Signal Transduction, Ageing and Disease. / 2019 / PubMed / Full text
FOXO3, a Molecular Search for the Fountain of Youth. / 07.03.2019 / PubMed / Full text
10-year follow-up of the Super-Seniors Study: compression of morbidity and genetic factors. / 28.02.2019 / PubMed / Full text
Taste receptors, innate immunity and longevity: the case of TAS2R16 gene. / 2019 / PubMed / Full text
FOXO3-Engineered Human ESC-Derived Vascular Cells Promote Vascular Protection and Regeneration. / 07.03.2019 / PubMed / Full text
Analysis of FOXO3 Gene Polymorphisms Associated with Human Longevity. / 2019 / PubMed / Full text
Recent advances in understanding the role of FOXO3. / 2018 / PubMed / Full text
FOXO are required for intervertebral disk homeostasis during aging and their deficiency promotes disk degeneration. / 10.2018 / PubMed / Full text
The longevity SNP rs2802292 uncovered: HSF1 activates stress-dependent expression of FOXO3 through an intronic enhancer. / 20.06.2018 / PubMed / Full text
Minimal Shortening of Leukocyte Telomere Length Across Age Groups in a Cross-Sectional Study for Carriers of a Longevity-Associated FOXO3 Allele. / 08.10.2018 / PubMed / Full text
FOXO in Neural Cells and Diseases of the Nervous System. / 2018 / PubMed / Full text
Genetic Variation in FOXO3 is Associated with Self-Rated Health in a Population-Based Sample of Older Individuals. / 08.10.2018 / PubMed / Full text
Identification and characterization of two functional variants in the human longevity gene FOXO3. / 12.12.2017 / PubMed / Full text
Effects of FOXO3 Polymorphisms on Survival to Extreme Longevity in Four Centenarian Studies. / 08.10.2018 / PubMed / Full text
FOXO Transcriptional Factors and Long-Term Living. / 2017 / PubMed / Full text
FOXO3 longevity interactome on chromosome 6. / 10.2017 / PubMed / Full text
The stress response factor daf-16/FOXO is required for multiple compound families to prolong the function of neurons with Huntington's disease. / 21.06.2017 / PubMed / Full text
Age-related reduction in the expression of FOXO transcription factors and correlations with intervertebral disc degeneration. / 12.2017 / PubMed / Full text
FOXO3 Transcription Factor Is Essential for Protecting Hematopoietic Stem and Progenitor Cells from Oxidative DNA Damage. / 17.02.2017 / PubMed / Full text
Modulation of gut microbiota and delayed immunosenescence as a result of syringaresinol consumption in middle-aged mice. / 15.12.2016 / PubMed / Full text
Genetic Association Analysis of Common Variants in FOXO3 Related to Longevity in a Chinese Population. / 2016 / PubMed / Full text
Genome-wide Association Study of Parental Life Span. / 01.10.2017 / PubMed / Full text
Longevity-Associated FOXO3 Genotype and its Impact on Coronary Artery Disease Mortality in Japanese, Whites, and Blacks: A Prospective Study of Three American Populations. / 01.05.2017 / PubMed / Full text
Genomewide meta-analysis identifies loci associated with IGF-I and IGFBP-3 levels with impact on age-related traits. / 10.2016 / PubMed / Full text
Diabetic complications within the context of aging: Nicotinamide adenine dinucleotide redox, insulin C-peptide, sirtuin 1-liver kinase B1-adenosine monophosphate-activated protein kinase positive feedback and forkhead box O3. / 07.2016 / PubMed / Full text
The FoxO3 gene and cause-specific mortality. / 08.2016 / PubMed / Full text
Association study of polymorphisms in FOXO3, AKT1 and IGF-2R genes with human longevity in a Han Chinese population. / 05.01.2016 / PubMed / Full text
Genetic factors and epigenetic mechanisms of longevity: current perspectives. / 2015 / PubMed / Full text
Long live FOXO: unraveling the role of FOXO proteins in aging and longevity. / 04.2016 / PubMed / Full text
Association Analysis of FOXO3 Longevity Variants With Blood Pressure and Essential Hypertension. / 01.11.2016 / PubMed / Full text
Mitochondrial metabolism in hematopoietic stem cells requires functional FOXO3. / 09.2015 / PubMed / Full text
The MicroRNA-132 and MicroRNA-212 Cluster Regulates Hematopoietic Stem Cell Maintenance and Survival with Age by Buffering FOXO3 Expression. / 16.06.2015 / PubMed / Full text
Age-Based Differences in the Genetic Determinants of Glycemic Control: A Case of FOXO3 Variations. / 2015 / PubMed / Full text
Tocotrienol-rich fraction prevents cellular aging by modulating cell proliferation signaling pathways. / 2015 / PubMed / Full text
FOXO3 variants are beneficial for longevity in Southern Chinese living in the Red River Basin: A case-control study and meta-analysis. / 27.04.2015 / PubMed / Full text
FOXO3: A Major Gene for Human Longevity--A Mini-Review. / 2015 / PubMed / Full text
Senescence of human skin-derived precursors regulated by Akt-FOXO3-p27(KIP¹)/p15(INK⁴b) signaling. / 08.2015 / PubMed / Full text
SIRT6 minor allele genotype is associated with >5-year decrease in lifespan in an aged cohort. / 2014 / PubMed / Full text
Association of the insulin-like growth factor binding protein 3 (IGFBP-3) polymorphism with longevity in Chinese nonagenarians and centenarians. / 11.2014 / PubMed / Full text
E2F transcription factor 1 regulates cellular and organismal senescence by inhibiting Forkhead box O transcription factors. / 05.12.2014 / PubMed / Full text
GxE interactions between FOXO genotypes and drinking tea are significantly associated with prevention of cognitive decline in advanced age in China. / 04.2015 / PubMed / Full text
Shorter men live longer: association of height with longevity and FOXO3 genotype in American men of Japanese ancestry. / 2014 / PubMed / Full text
FOXO3 and related transcription factors in development, aging, and exceptional longevity. / 04.2015 / PubMed / Full text

HGSПравить

Handgrip strength asymmetry is associated with future falls in older Americans. / 27.11.2020 / PubMed / Full text
Examining Additional Aspects of Muscle Function with a Digital Handgrip Dynamometer and Accelerometer in Older Adults: A Pilot Study. / 31.10.2020 / PubMed / Full text
The Relationship between Muscular Strength and Depression in Older Adults with Chronic Disease Comorbidity. / 18.09.2020 / PubMed / Full text
Handgrip Strength in the Korean Population: Normative Data and Cutoff Values. / 12.2019 / PubMed / Full text
Handgrip Strength Asymmetry and Weakness Are Associated with Lower Cognitive Function: A Panel Study. / 09.2020 / PubMed / Full text
Handgrip Strength Asymmetry and Weakness are Differentially Associated with Functional Limitations in Older Americans. / 06.05.2020 / PubMed / Full text
Absolute and Body Mass Index Normalized Handgrip Strength Percentiles by Gender, Ethnicity, and Hand Dominance in Americans. / 2020 / PubMed / Full text
Hand grip strength variability during serial testing as an entropic biomarker of aging: a Poincaré plot analysis. / 13.01.2020 / PubMed / Full text
Physical Activity and Fitness in White- and Blue-Collar Retired Men. / 11-12.2019 / PubMed / Full text
Association between Hand Grip Strength and Self-Rated Health in Middle- and Old-Aged Korean Citizens. / 01.2020 / PubMed / Full text
Weakness May Have a Causal Association With Early Mortality in Older Americans: A Matched Cohort Analysis. / 05.2020 / PubMed / Full text
Associations Between Dietary Patterns and Handgrip Strength: The Korea National Health and Nutrition Examination Survey 2014-2016. / 08.2020 / PubMed / Full text
Effect of relative handgrip strength on cardiovascular disease among Korean adults aged 45 years and older: Results from the Korean Longitudinal Study of Aging (2006-2016). / 01-02.2020 / PubMed / Full text
Weakness and cognitive impairment are independently and jointly associated with functional decline in aging Americans. / 09.2020 / PubMed / Full text
Association of phase angle with sarcopenia and its components in physically active older women. / 08.2020 / PubMed / Full text
Age- and sex-related differences in muscle strength and physical performance in older Chinese. / 05.2020 / PubMed / Full text
Decreased Handgrip Strength is Associated With Impairments in Each Autonomous Living Task for Aging Adults in the United States. / 2019 / PubMed / Full text
The impact of muscle function, muscle mass and sarcopenia on independent ageing in very old Swedish men. / 29.05.2019 / PubMed / Full text
Nutritional status of older patients on hemodialysis: Which nutritional markers can best predict clinical outcomes? / 09.2019 / PubMed / Full text
Handgrip strength, depression, and all-cause mortality in Korean older adults. / 03.05.2019 / PubMed / Full text
Handgrip Strength of World Trade Center (WTC) Responders: The Role of Re-Experiencing Posttraumatic Stress Disorder (PTSD) Symptoms. / 29.03.2019 / PubMed / Full text
Vitamin D is related to handgrip strength in adult men aged 50 years and over: A population study from the TCLSIH cohort study. / 05.2019 / PubMed / Full text
Reference data on hand grip and lower limb strength using the Nintendo Wii balance board: a cross-sectional study of 354 subjects from 20 to 99 years of age. / 12.01.2019 / PubMed / Full text
Determining functional activity profiles in patients with upper extremity disorders: is there effect modification by hand-grip strength? / 2018 / PubMed / Full text
Hand grip strength as a physical biomarker of aging from the perspective of a Fibonacci mathematical modeling. / 29.11.2018 / PubMed / Full text
Body image satisfaction, sociodemographic, functional and clinical aspects of community-dwelling older adults. / 07-09.2018 / PubMed / Full text
Orthostatic hypotension and physical functioning in older adults: A systematic review and meta-analysis. / 12.2018 / PubMed / Full text
Inverse relationship between serum hsCRP concentration and hand grip strength in older adults: a nationwide population-based study. / 16.08.2018 / PubMed / Full text
Association of Anthropometric and Nutrition Status Indicators with Hand Grip Strength and Gait Speed in Older Adults. / 03.2019 / PubMed / Full text
Handgrip Strength and Health in Aging Adults. / 09.2018 / PubMed / Full text
Hand grip strength as a predictor of postoperative complications in esophageal cancer patients undergoing esophagectomy. / 01.2018 / PubMed / Full text
Age-related declines in the swallowing muscle strength of men and women aged 20-89 years: A cross-sectional study on tongue pressure and jaw-opening force in 980 subjects. / 09-10.2018 / PubMed / Full text
Association between handgrip strength, balance, and knee flexion/extension strength in older adults. / 2018 / PubMed / Full text
Movement velocity in the chair squat is associated with measures of functional capacity and cognition in elderly people at low risk of fall. / 2018 / PubMed / Full text
Inverse Association Between Height-Increasing Alleles and Extreme Longevity in Japanese Women. / 17.04.2018 / PubMed / Full text
Hand-grip strength among older adults in Singapore: a comparison with international norms and associative factors. / 04.08.2017 / PubMed / Full text
Development of an updated normative data table for hand grip and pinch strength: A pilot study. / 01.07.2017 / PubMed / Full text
Association between muscular strength and intrarenal vascular resistance in middle-aged and older individuals. / 05.2017 / PubMed / Full text
Associations of sit-up ability with sarcopenia classification measures in Japanese older women. / 12.2016 / PubMed / Full text
Handgrip Strength in Old and Very Old Adults: Mood, Cognition, Function, and Mortality. / 03.2017 / PubMed / Full text
Forearm muscle quality as a better indicator of physical performance than handgrip strength in older male ground golf players aged 70 to 89. / 14.12.2016 / PubMed / Full text
A foodservice approach to enhance energy intake of elderly subacute patients: a pilot study to assess impact on patient outcomes and cost. / 01.05.2017 / PubMed / Full text
Sarcopenia Is Highly Prevalent in Older Medical Patients With Mobility Limitation. / 02.2017 / PubMed / Full text
Normative Values of Hand Grip Strength for Elderly Singaporeans Aged 60 to 89 Years: A Cross-Sectional Study. / 01.09.2016 / PubMed / Full text
Handgrip strength, quadriceps muscle power, and optimal shortening velocity roles in maintaining functional abilities in older adults living in a long-term care home: a 1-year follow-up study. / 2016 / PubMed / Full text
Age-related decline in skeletal muscle mass and function among elderly men and women in Shanghai, China: a cross sectional study. / 2016 / PubMed / Full text
Effect of Dietary Patterns on Muscle Strength and Physical Performance in the Very Old: Findings from the Newcastle 85 Study. / 2016 / PubMed / Full text
Clinically relevant weakness in diverse populations of older adults participating in the International Mobility in Aging Study. / 02.2016 / PubMed / Full text
Age-related change in handgrip strength in men and women: is muscle quality a contributing factor? / 02.2016 / PubMed / Full text
Physical performance and its association with anthropometric and body composition variables in the elderly. / 12.2015 / PubMed / Full text
Lean Body Mass Associated with Upper Body Strength in Healthy Older Adults While Higher Body Fat Limits Lower Extremity Performance and Endurance. / 26.08.2015 / PubMed / Full text

PTHПравить

Vitamin D Receptor Polymorphisms in Sex-Frailty Paradox. / 05.09.2020 / PubMed / Full text
Parathyroid hormone ameliorates temporomandibular joint osteoarthritic-like changes related to age. / 04.2020 / PubMed / Full text
A Vitamin D, Calcium and Leucine-Enriched Whey Protein Nutritional Supplement Improves Measures of Bone Health in Sarcopenic Non-Malnourished Older Adults: The PROVIDE Study. / 10.2019 / PubMed / Full text
EVALUATION OF PLASMA 25-HYDROXYVITAMIN D, IONIZED CALCIUM, AND PARATHYROID HORMONE IN GREEN SEA TURTLES ([i]CHELONIA MYDAS[/i]) EXPOSED TO DIFFERENT INTENSITIES OF ULTRAVIOLET B RADIATION. / 13.06.2019 / PubMed / Full text
The relative influence of serum ionized calcium and 25-hydroxyvitamin D in regulating PTH secretion in healthy subjects. / 08.2019 / PubMed / Full text
Vitamin D in Relation to Incident Sarcopenia and Changes in Muscle Parameters Among Older Adults: The KORA-Age Study. / 08.2019 / PubMed / Full text
Extraskeletal Calcifications in Hutchinson-Gilford Progeria Syndrome. / 08.2019 / PubMed / Full text
Sequential Treatment with Eldecalcitol After PTH Improves Bone Mechanical Properties of Lumbar Spine and Femur in Aged Ovariectomized Rats. / 03.2019 / PubMed / Full text
Effect of Vitamin D Treatment on Glucose Homeostasis and Metabolism in Lebanese Older Adults: A Randomized Controlled Trial. / 2018 / PubMed / Full text
Testosterone level in aging male with different glucose tolerance state and its association with osteocalcin. / 03.2019 / PubMed / Full text
Early effects of parathyroid hormone on vascularized bone regeneration and implant osseointegration in aged rats. / 10.2018 / PubMed / Full text
Mito-mice∆ and mitochondrial DNA mutator mice as models of human osteoporosis caused not by aging but by hyperparathyroidism. / 01.11.2018 / PubMed / Full text
Intermittent PTH 1-34 administration improves the marrow microenvironment and endothelium-dependent vasodilation in bone arteries of aged rats. / 01.06.2018 / PubMed / Full text
Nonandrogenic Anabolic Hormones Predict Risk of Frailty: European Male Ageing Study Prospective Data. / 01.08.2017 / PubMed / Full text
Effect of age and gender on serum periostin: Relationship to cortical measures, bone turnover and hormones. / 06.2017 / PubMed / Full text
[Clinical and anatomic study of preserving parathyroid specific adipose attachments in total thyroidectomy]. / 01.11.2016 / PubMed / Full text
Intermittent parathyroid hormone administration attenuates endothelial dysfunction in old rats. / 01.01.2017 / PubMed / Full text
The Effect of Moderate Dietary Protein and Phosphate Restriction on Calcium-Phosphate Homeostasis in Healthy Older Cats. / 09.2016 / PubMed / Full text
Sclerostin and Bone Aging: A Mini-Review. / 2016 / PubMed / Full text
Lifelong challenge of calcium homeostasis in male mice lacking TRPV5 leads to changes in bone and calcium metabolism. / 03.05.2016 / PubMed / Full text
The association of serum cathepsin B concentration with age-related cardiovascular-renal subclinical state in a healthy Chinese population. / 07-08.2016 / PubMed / Full text
Serum concentrations of 25-hydroxyvitamin D and its association with bone mineral density and serum parathyroid hormone levels during winter in urban males from Guiyang, Southwest China. / 28.03.2016 / PubMed / Full text
[Regulatory mechanism of circulating inorganic phosphate]. / 02.2016 / PubMed / Full text
Relation of Age, Sex and Bone Mineral Density to Serum 25-Hydroxyvitamin D Levels in Chinese Women and Men. / 11.2015 / PubMed / Full text
Establishment of a normal reference value of parathyroid hormone in a large healthy Chinese population and evaluation of its relation to bone turnover and bone mineral density. / 05.2016 / PubMed / Full text
Vitamin D, PTH and the risk of overall and disease-specific mortality: Results of the Longitudinal Aging Study Amsterdam. / 11.2016 / PubMed / Full text
Differential sclerostin and parathyroid hormone response to exercise in boys and men. / 03.2016 / PubMed / Full text
Enhanced parathyroid hormone levels are associated with left ventricle hypertrophy in very elderly men and women. / 09.2015 / PubMed / Full text
Factors associated with low femoral neck bone mineral density in very elderly Chinese males. / 11-12.2015 / PubMed / Full text
Parathyroid Hormone Levels in Healthy Children and Adolescents. / 2015 / PubMed / Full text
Molecular aspects of intestinal calcium absorption. / 21.06.2015 / PubMed / Full text
Associations between frailty and serum N-terminal propeptide of type I procollagen and 25-hydroxyvitamin D in older Spanish women: The Toledo Study for Healthy Aging. / 09.2015 / PubMed / Full text
Vitamin D metabolites and bone mineral density: The multi-ethnic study of atherosclerosis. / 09.2015 / PubMed / Full text
Thresholds for Serum 25(OH)D Concentrations With Respect to Different Outcomes. / 06.2015 / PubMed / Full text
Vitamin D Status Is Positively Associated with Calcium Absorption among Postmenopausal Thai Women with Low Calcium Intakes. / 05.2015 / PubMed / Full text
Bone health in phenylketonuria: a systematic review and meta-analysis. / 15.02.2015 / PubMed / Full text
Brief report: Does PTH increase with age, independent of 25-hydroxyvitamin D, phosphate, renal function, and ionized calcium? / 05.2015 / PubMed / Full text
Co-administration of antiresorptive and anabolic agents: a missed opportunity. / 05.2015 / PubMed / Full text
Serum 25-Hydroxyvitamin D and Parathyroid Hormone Levels in Non-Lactating Women with Post-Partum Thyroiditis: The Effect of L-Thyroxine Treatment. / 06.2015 / PubMed / Full text
Effect of high parathyroid hormone level on bone mineral density in a vitamin D-sufficient population: Korea National Health and Nutrition Examination Survey 2008-2010. / 2014 / PubMed / Full text
Oral administration of soluble guanylate cyclase agonists to rats results in osteoclastic bone resorption and remodeling with new bone formation in the appendicular and axial skeleton. / 04.2015 / PubMed / Full text
The influence of age on bone metabolism in mares during late pregnancy and lactation. / 10.2014 / PubMed / Full text
Low-dose PTH increases osteoblast activity via decreased Mef2c/Sost in senescent osteopenic mice. / 10.2014 / PubMed / Full text
Vitamin D and endothelial vasodilation in older individuals: data from the PIVUS study. / 09.2014 / PubMed / Full text
Radiometrical, hormonal and biological correlates of skeletal growth in the female rat from birth to senescence. / 04-06.2014 / PubMed / Full text
[Correlation of sex hormones and parathyroid hormone with biochemical markers of bone turnover in aged men]. / 03.2014 / PubMed
Dietary calcium does not interact with vitamin D₃ in terms of determining the response and catabolism of serum 25-hydroxyvitamin D during winter in older adults. / 06.2014 / PubMed / Full text
Aging periosteal progenitor cells have reduced regenerative responsiveness to bone injury and to the anabolic actions of PTH 1-34 treatment. / 05.2014 / PubMed / Full text
Decline in calcitonin receptor expression in osteocytes with age. / 05.2014 / PubMed / Full text
Variation in the [[PTH2R]] gene is associated with age-related degenerative changes in the lumbar spine. / 01.2015 / PubMed / Full text
Estrogen deficiency-induced Ca balance impairment is associated with decrease in expression of epithelial Ca transport proteins in aged female rats. / 06.02.2014 / PubMed / Full text

LMNAПравить

Metformin alters peripheral blood mononuclear cells (PBMC) senescence biomarkers gene expression in type 2 diabetic patients. / 01.2021 / PubMed / Full text
Protein structural and mechanistic basis of progeroid laminopathies. / 16.08.2020 / PubMed / Full text
Progerin Expression Induces Inflammation, Oxidative Stress and Senescence in Human Coronary Endothelial Cells. / 12.05.2020 / PubMed / Full text
The JAK1/2 inhibitor ruxolitinib delays premature aging phenotypes. / 04.2020 / PubMed / Full text
Pharmacotherapy to gene editing: potential therapeutic approaches for Hutchinson-Gilford progeria syndrome. / 04.2020 / PubMed / Full text
Long term breeding of the Lmna G609G progeric mouse: Characterization of homozygous and heterozygous models. / 02.2020 / PubMed / Full text
Epigenetic signatures of Werner syndrome occur early in life and are distinct from normal epigenetic aging processes. / 10.2019 / PubMed / Full text
Transient introduction of human telomerase mRNA improves hallmarks of progeria cells. / 08.2019 / PubMed / Full text
A humanized yeast system to analyze cleavage of prelamin A by ZMPSTE24. / 15.03.2019 / PubMed / Full text
Impaired immune surveillance accelerates accumulation of senescent cells and aging. / 21.12.2018 / PubMed / Full text
Endothelial progerin expression causes cardiovascular pathology through an impaired mechanoresponse. / 01.02.2019 / PubMed / Full text
Targeting the phospholipase A2 receptor ameliorates premature aging phenotypes. / 12.2018 / PubMed / Full text
Altered modulation of lamin A/C-HDAC2 interaction and p21 expression during oxidative stress response in HGPS. / 10.2018 / PubMed / Full text
Cellular stress and AMPK activation as a common mechanism of action linking the effects of metformin and diverse compounds that alleviate accelerated aging defects in Hutchinson-Gilford progeria syndrome. / 09.2018 / PubMed / Full text
Proteomic changes during adult stage in pre-optic, hypothalamus, hippocampus and pituitary regions of female rat brain following neonatal exposure to estradiol-17β. / 15.09.2018 / PubMed / Full text
RECQ helicase disease and related progeroid syndromes: RECQ2018 meeting. / 07.2018 / PubMed / Full text
Upregulation of the aging related LMNA splice variant progerin in dilated cardiomyopathy. / 2018 / PubMed / Full text
Increasing autophagy and blocking Nrf2 suppress laminopathy-induced age-dependent cardiac dysfunction and shortened lifespan. / 06.2018 / PubMed / Full text
Lipodystrophic syndromes due to LMNA mutations: recent developments on biomolecular aspects, pathophysiological hypotheses and therapeutic perspectives. / 01.01.2018 / PubMed / Full text
Differential stem cell aging kinetics in Hutchinson-Gilford progeria syndrome and Werner syndrome. / 04.2018 / PubMed / Full text
Mandibuloacral dysplasia: A premature ageing disease with aspects of physiological ageing. / 03.2018 / PubMed / Full text
Hutchinson-Gilford Progeria Syndrome: A Premature Aging Disease. / 05.2018 / PubMed / Full text
Progerin-Induced Replication Stress Facilitates Premature Senescence in Hutchinson-Gilford Progeria Syndrome. / 15.07.2017 / PubMed / Full text
Physiological and Pathological Aging Affects Chromatin Dynamics, Structure and Function at the Nuclear Edge. / 2016 / PubMed / Full text
Clinical Trial of the Protein Farnesylation Inhibitors Lonafarnib, Pravastatin, and Zoledronic Acid in Children With Hutchinson-Gilford Progeria Syndrome. / 12.07.2016 / PubMed / Full text
Hutchinson-Gilford Progeria Syndrome: A premature aging disease caused by LMNA gene mutations. / 01.2017 / PubMed / Full text
Progeria and the early aging in children: a case report. / 17.02.2016 / PubMed
A Heterozygous ZMPSTE24 Mutation Associated with Severe Metabolic Syndrome, Ectopic Fat Accumulation, and Dilated Cardiomyopathy. / 25.04.2016 / PubMed / Full text
Understanding Vascular Diseases: Lessons From Premature Aging Syndromes. / 05.2016 / PubMed / Full text
Molecular insights into the premature aging disease progeria. / 04.2016 / PubMed / Full text
LMNA mutations resulting in lipodystrophy and HIV protease inhibitors trigger vascular smooth muscle cell senescence and calcification: Role of ZMPSTE24 downregulation. / 02.2016 / PubMed / Full text
Methylene blue alleviates nuclear and mitochondrial abnormalities in progeria. / 04.2016 / PubMed / Full text
Pluripotent stem cells to model Hutchinson-Gilford progeria syndrome (HGPS): Current trends and future perspectives for drug discovery. / 11.2015 / PubMed / Full text
All-trans retinoic acid and rapamycin normalize Hutchinson Gilford progeria fibroblast phenotype. / 06.10.2015 / PubMed / Full text
New look at the role of progerin in skin aging. / 03.2015 / PubMed / Full text
Progerin reduces LAP2α-telomere association in Hutchinson-Gilford progeria. / 27.08.2015 / PubMed / Full text
Overexpression of Lamin B Receptor Results in Impaired Skin Differentiation. / 2015 / PubMed / Full text
Sustained accumulation of prelamin A and depletion of lamin A/C both cause oxidative stress and mitochondrial dysfunction but induce different cell fates. / 2015 / PubMed / Full text
Age-Related Lipid Metabolic Signature in Human LMNA-Lipodystrophic Stem Cell-Derived Adipocytes. / 07.2015 / PubMed / Full text
Transgene silencing of the Hutchinson-Gilford progeria syndrome mutation results in a reversible bone phenotype, whereas resveratrol treatment does not show overall beneficial effects. / 08.2015 / PubMed / Full text
Sulforaphane enhances progerin clearance in Hutchinson-Gilford progeria fibroblasts. / 02.2015 / PubMed / Full text
Expression of progerin in aging mouse brains reveals structural nuclear abnormalities without detectible significant alterations in gene expression, hippocampal stem cells or behavior. / 01.03.2015 / PubMed / Full text
Accumulation of prelamin A compromises NF-κB-regulated B-lymphopoiesis in a progeria mouse model. / 2013 / PubMed / Full text
Prelamin A accumulation and stress conditions induce impaired Oct-1 activity and autophagy in prematurely aged human mesenchymal stem cell. / 04.2014 / PubMed / Full text
Antagonistic functions of LMNA isoforms in energy expenditure and lifespan. / 05.2014 / PubMed / Full text
Epigenetic involvement in Hutchinson-Gilford progeria syndrome: a mini-review. / 2014 / PubMed / Full text
RB and lamins in cell cycle regulation and aging. / 2014 / PubMed / Full text
Search and insights into novel genetic alterations leading to classical and atypical Werner syndrome. / 2014 / PubMed / Full text
Mapping disease-related missense mutations in the immunoglobulin-like fold domain of lamin A/C reveals novel genotype-phenotype associations for laminopathies. / 06.2014 / PubMed / Full text

ARCПравить

The Polymorphism rs2968 of [i]LSS[/i] Gene Confers Susceptibility to Age-Related Cataract. / 11.2020 / PubMed / Full text
Decreased Anti-Müllerian hormone and Anti-Müllerian hormone receptor type 2 in hypothalami of old Japanese Black cows. / 19.08.2020 / PubMed / Full text
Resveratrol delay the cataract formation against naphthalene-induced experimental cataract in the albino rats. / 01.2020 / PubMed / Full text
lncRNA H19 contributes to oxidative damage repair in the early age-related cataract by regulating miR-29a/TDG axis. / 09.2019 / PubMed / Full text
Laminin α4 overexpression in the anterior lens capsule may contribute to the senescence of human lens epithelial cells in age-related cataract. / 10.05.2019 / PubMed / Full text
Dietary vitamin and carotenoid intake and risk of age-related cataract. / 01.01.2019 / PubMed / Full text
The impact of GJA8 SNPs on susceptibility to age-related cataract. / 12.2018 / PubMed / Full text
MicroRNA binding mediated Functional sequence variant in 3'-UTR of DNA repair Gene XPC in Age-related Cataract. / 12.10.2018 / PubMed / Full text
Serum selenium levels are associated with age-related cataract. / 25.09.2018 / PubMed / Full text
Chronic treatment with tributyltin induces sexually dimorphic alterations in the hypothalamic POMC system of adult mice. / 12.2018 / PubMed / Full text
Exercise Training Protects Against Aging-Induced Cognitive Dysfunction via Activation of the Hippocampal PGC-1α/FNDC5/BDNF Pathway. / 09.2018 / PubMed / Full text
miRNA Long-Term Response to Early Metabolic Environmental Challenge in Hypothalamic Arcuate Nucleus. / 2018 / PubMed / Full text
β-amyloid expression in age-related cataract lens epithelia and the effect of β-amyloid on oxidative damage in human lens epithelial cells. / 2017 / PubMed / Full text
17α-estradiol acts through hypothalamic pro-opiomelanocortin expressing neurons to reduce feeding behavior. / 02.2018 / PubMed / Full text
The effect of ARC ablation on skeletal muscle morphology, function, and apoptotic signaling during aging. / 01.2018 / PubMed / Full text
High-throughput sequencing reveals novel lincRNA in age-related cataract. / 12.2017 / PubMed / Full text
From bench (laboratory) to bed (hospital/home): How to explore effective natural and synthetic PAK1-blockers/longevity-promoters for cancer therapy. / 15.12.2017 / PubMed / Full text
Age-associated gene expression changes in the arcuate nucleus of male rhesus macaques. / 08.2017 / PubMed / Full text
Effects of active immunization against GnRH versus surgical castration on hypothalamic-pituitary function in boars. / 15.07.2017 / PubMed / Full text
Differential effects of metformin on age related comorbidities in older men with type 2 diabetes. / 04.2017 / PubMed / Full text
Expression of DNA repair genes in lens cortex of age-related cortical cataract. / 04.2017 / PubMed / Full text
Interactions between Kisspeptin Neurons and Hypothalamic Tuberoinfundibular Dopaminergic Neurons in Aged Female Rats. / 28.12.2016 / PubMed / Full text
Age-related changes in acute central leptin effects on energy balance are promoted by obesity. / 01.12.2016 / PubMed / Full text
Preventive effects of dexmedetomidine on the development of cognitive dysfunction following systemic inflammation in aged rats. / 02.2017 / PubMed / Full text
Relationship Between the Altered Expression and Epigenetics of GSTM3 and Age-Related Cataract. / 01.09.2016 / PubMed / Full text
Nuclear and Mitochondrial DNA of Age-Related Cataract Patients Are Susceptible to Oxidative Damage. / 04.2017 / PubMed / Full text
Effects of senescent lens epithelial cells on the severity of age-related cortical cataract in humans: A case-control study. / 06.2016 / PubMed / Full text
Expression Profiling of DNA Methylation and Transcriptional Repression Associated Genes in Lens Epithelium Cells of Age-Related Cataract. / 04.2017 / PubMed / Full text
Prevalence of Age-Related Cataract and Cataract Surgery in a Chinese Adult Population: The Taizhou Eye Study. / 03.2016 / PubMed / Full text
Polymorphism rs7278468 is associated with Age-related cataract through decreasing transcriptional activity of the CRYAA promoter. / 17.03.2016 / PubMed / Full text
Silent information regulator T1 in aqueous humor of patients with cataract. / 2016 / PubMed / Full text
Evaluation and Comparison of the Indices of Systemic Oxidative Stress among Black-Africans with Age-related Cataracts or Primary Glaucoma. / 10-12.2015 / PubMed / Full text
Associations of Polymorphisms in MTHFR Gene with the Risk of Age-Related Cataract in Chinese Han Population: A Genotype-Phenotype Analysis. / 2015 / PubMed / Full text
Flavonoid intake and the risk of age-related cataract in China's Heilongjiang Province. / 2015 / PubMed / Full text
Areca nut alkaloids induce irreparable DNA damage and senescence in fibroblasts and may create a favourable environment for tumour progression. / 05.2016 / PubMed / Full text
The Association of Outdoor Activity and Age-Related Cataract in a Rural Population of Taizhou Eye Study: Phase 1 Report. / 2015 / PubMed / Full text
Epigenetic changes of the Klotho gene in age-related cataracts. / 2015 / PubMed
Glutathione S-transferase GSTM 1, null genotype may be associated with susceptibility to age-related cataract. / 01-02.2015 / PubMed / Full text
Expression and methylation of DNA repair genes in lens epithelium cells of age-related cataract. / 08-09.2014 / PubMed / Full text
Effects of Age and Estradiol on Gene Expression in the Rhesus Macaque Hypothalamus. / 2015 / PubMed / Full text
Vitamin E and risk of age-related cataract: a meta-analysis. / 10.2015 / PubMed / Full text
A fine balance: Regulation of hippocampal Arc/Arg3.1 transcription, translation and degradation in a rat model of normal cognitive aging. / 11.2014 / PubMed / Full text
Association between DNA repair genes (XPD and XRCC1) polymorphisms and susceptibility to age-related cataract (ARC): a meta-analysis. / 08.2014 / PubMed / Full text
Hypothalamic molecular changes underlying natural reproductive senescence in the female rat. / 09.2014 / PubMed / Full text
The changes of 8-OHdG, hOGG1, APE1 and Pol β in lenses of patients with age-related cataract. / 04.2015 / PubMed / Full text
Polymorphisms of DNA repair genes OGG1 and XPD and the risk of age-related cataract in Egyptians. / 2014 / PubMed / Full text
G-protein coupled estrogen receptor, estrogen receptor α, and progesterone receptor immunohistochemistry in the hypothalamus of aging female rhesus macaques given long-term estradiol treatment. / 08.2014 / PubMed / Full text
RNA granule component TDRD7 gene polymorphisms in a Han Chinese population with age-related cataract. / 02.2014 / PubMed / Full text

IL6Править

Basic immunology may lead to translational therapeutic rationale: SARS-CoV-2 and rheumatic diseases. / 09.2020 / PubMed / Full text
ATM-deficient neural precursors develop senescence phenotype with disturbances in autophagy. / 09.2020 / PubMed / Full text
The microRNA-34a-Induced Senescence-Associated Secretory Phenotype (SASP) Favors Vascular Smooth Muscle Cells Calcification. / 23.06.2020 / PubMed / Full text
Impact of Influenza on Pneumococcal Vaccine Effectiveness during [i]Streptococcus pneumoniae[/i] Infection in Aged Murine Lung. / 11.06.2020 / PubMed / Full text
Patterns of multi-domain cognitive aging in participants of the Long Life Family Study. / 10.2020 / PubMed / Full text
Cholest-4,6-Dien-3-One Promote Epithelial-To-Mesenchymal Transition (EMT) in Biliary Tree Stem/Progenitor Cell Cultures In Vitro. / 15.11.2019 / PubMed / Full text
Single xenotransplant of rat brown adipose tissue prolonged the ovarian lifespan of aging mice by improving follicle survival. / 12.2019 / PubMed / Full text
Intestinal stem cells acquire premature senescence and senescence associated secretory phenotype concurrent with persistent DNA damage after heavy ion radiation in mice. / 25.06.2019 / PubMed / Full text
N-acetylcysteine and alpha-lipoic acid improve antioxidant defenses and decrease oxidative stress, inflammation and serum lipid levels in ovariectomized rats via estrogen-independent mechanisms. / 05.2019 / PubMed / Full text
Age-dependent hepatic alterations induced by a high-fat high-fructose diet. / 05.2019 / PubMed / Full text
Protective effects of a novel facial cream against environmental pollution: in vivo and in vitro assessment. / 2018 / PubMed / Full text
Expression of pro- and anti-inflammatory cytokines and chemokines during the ovulatory cycle and effects of aging on their expression in the uterine mucosa of laying hens. / 11.2018 / PubMed / Full text
Torquetenovirus (TTV) load is associated with mortality in Italian elderly subjects. / 02.10.2018 / PubMed / Full text
Review and meta-analysis of genetic polymorphisms associated with exceptional human longevity. / 10.2018 / PubMed / Full text
Composition and richness of the serum microbiome differ by age and link to systemic inflammation. / 06.2018 / PubMed / Full text
Interleukin 6 Knockout Inhibits Aging-Related Accumulation of p53 in the Mouse Myocardium. / 16.01.2019 / PubMed / Full text
Age Dependent Hypothalamic and Pituitary Responses to Novel Environment Stress or Lipopolysaccharide in Rats. / 2018 / PubMed / Full text
Sulodexide Slows Down the Senescence of Aortic Endothelial Cells Exposed to Serum from Patients with Peripheral Artery Diseases. / 2018 / PubMed / Full text
Dexamethasone downregulates SIRT1 and IL6 and upregulates EDN1 genes in stem cells derived from gingivae via the AGE/RAGE pathway. / 03.2018 / PubMed / Full text
Senescence promotes in vivo reprogramming through p16 and IL-6. / 04.2018 / PubMed / Full text
Predictive value of multiple cytokines and chemokines for mortality in an admixed population: 15-year follow-up of the Bambui-Epigen (Brazil) cohort study of aging. / 11.2017 / PubMed / Full text
Voluntary running exercise protects against sepsis-induced early inflammatory and pro-coagulant responses in aged mice. / 08.08.2017 / PubMed / Full text
Cooperation between p21 and Akt is required for p53-dependent cellular senescence. / 10.2017 / PubMed / Full text
Low Oxygen Consumption is Related to a Hypomethylation and an Increased Secretion of IL-6 in Obese Subjects with Sleep Apnea-Hypopnea Syndrome. / 2017 / PubMed / Full text
Senescence-associated IL-6 and IL-8 cytokines induce a self- and cross-reinforced senescence/inflammatory milieu strengthening tumorigenic capabilities in the MCF-7 breast cancer cell line. / 04.05.2017 / PubMed / Full text
Skeletal muscle morphology and regulatory signalling in endurance-trained and sedentary individuals: The influence of ageing. / 07.2017 / PubMed / Full text
Cellular Senescence in Mouse Hippocampus After Irradiation and the Role of p53 and p21. / 01.04.2017 / PubMed / Full text
Chronic Resveratrol Treatment Inhibits MRC5 Fibroblast SASP-Related Protumoral Effects on Melanoma Cells. / 01.09.2017 / PubMed / Full text
Analysis of molecular networks and targets mining of Chinese herbal medicines on anti-aging. / 28.12.2016 / PubMed / Full text
Aging promotes neoplastic disease through effects on the tissue microenvironment. / 06.12.2016 / PubMed / Full text
The integration of epigenetics and genetics in nutrition research for CVD risk factors. / 08.2017 / PubMed / Full text
Serum Immune Mediators Independently Associate with Atherosclerosis in the Left (But Not Right) Carotid Territory of Older Individuals. / 12.2016 / PubMed / Full text
ATF6α regulates morphological changes associated with senescence in human fibroblasts. / 18.10.2016 / PubMed / Full text
Stimulation of cellular senescent processes, including secretory phenotypes and anti-oxidant responses, after androgen deprivation therapy in human prostate cancer. / 01.2017 / PubMed / Full text
Genetic variation and exercise-induced muscle damage: implications for athletic performance, injury and ageing. / 09.2016 / PubMed / Full text
Inflammation in Lafora Disease: Evolution with Disease Progression in Laforin and Malin Knock-out Mouse Models. / 07.2017 / PubMed / Full text
No Association between Variation in Longevity Candidate Genes and Aging-related Phenotypes in Oldest-old Danes. / 06.2016 / PubMed / Full text
Bone biology-related gingival transcriptome in ageing and periodontitis in non-human primates. / 05.2016 / PubMed / Full text
CNS-wide Sexually Dimorphic Induction of the Major Histocompatibility Complex 1 Pathway With Aging. / 01.2017 / PubMed / Full text
TNF Drives Monocyte Dysfunction with Age and Results in Impaired Anti-pneumococcal Immunity. / 01.2016 / PubMed / Full text
Neuroimmune and Neuropathic Responses of Spinal Cord and Dorsal Root Ganglia in Middle Age. / 2015 / PubMed / Full text
LIPID PROFILE AND CYTOKINES INTERACTIONS DURING SUCCESSFUL AGING. / 06.2015 / PubMed
Gene expression markers of age-related inflammation in two human cohorts. / 10.2015 / PubMed / Full text
Age-independent effects of hyaluronan amide derivative and growth hormone on human osteoarthritic chondrocytes. / 11.2015 / PubMed / Full text
Evidence of cellular senescence during the development of estrogen-induced pituitary tumors. / 06.2015 / PubMed / Full text
TRIM28/KAP1 regulates senescence. / 11.2014 / PubMed / Full text
The expression of IL6 and 21 in crossbred calves upregulated by inactivated trivalent FMD vaccine. / 03.04.2014 / PubMed / Full text

HPПравить

A narrative review of highly processed food addiction across the lifespan. / 28.10.2020 / PubMed / Full text
Beta Human Papillomavirus 8E6 Attenuates LATS Phosphorylation after Failed Cytokinesis. / 01.06.2020 / PubMed / Full text
Cardiac baroreflex hysteresis is one of the determinants of the heart period variability asymmetry. / 01.10.2019 / PubMed / Full text
Aged rats with different performances at environmental enrichment onset display different modulation of habituation and aversive memory. / 05.2019 / PubMed / Full text
Extranuclear DNA accumulates in aged cells and contributes to senescence and inflammation. / 04.2019 / PubMed / Full text
Comparison between probabilistic and Wiener-Granger causality in assessing modifications of the cardiac baroreflex control with age. / 22.10.2018 / PubMed / Full text
CXCR3 CD8 T cells with naïve phenotype and high capacity for IFN-γ production are generated during homeostatic T-cell proliferation. / 10.2018 / PubMed / Full text
Mapping the Proxies of Memory and Learning Function in Senior Adults with High-performing, Normal Aging and Neurocognitive Disorders. / 2018 / PubMed / Full text
Role of Oral Nutritional Supplements Enriched with β-Hydroxy-β-Methylbutyrate in Maintaining Muscle Function and Improving Clinical Outcomes in Various Clinical Settings. / 2018 / PubMed / Full text
Effect of protein intake beyond habitual intakes following resistance training on cardiometabolic risk disease parameters in pre-conditioned older women. / 09.2018 / PubMed / Full text
Health care providers' perceptions of family caregivers' involvement in consultations within a geriatric hospital setting. / 07-08.2018 / PubMed / Full text
Influence of age and gender on the phase and strength of the relation between heart period and systolic blood pressure spontaneous fluctuations. / 01.03.2018 / PubMed / Full text
Species-specific role of gene-adjacent retroelements in human and mouse gastric carcinogenesis. / 15.04.2018 / PubMed / Full text
Associations of Helicobacter pylori infection and chronic atrophic gastritis with accelerated epigenetic ageing in older adults. / 10.10.2017 / PubMed / Full text
Aging Does Not Affect Axon Initial Segment Structure and Somatic Localization of Tau Protein in Hippocampal Neurons of Fischer 344 Rats. / 07-08.2017 / PubMed / Full text
Knee extensor power asymmetry is unrelated to functional mobility of older adults. / 11.2017 / PubMed / Full text
Reduced parahippocampal theta activity during spatial navigation in low, but not in high elderly performers. / 01.2018 / PubMed / Full text
The behavioral deficits and cognitive impairment are correlated with decreased IGF-II and ERK in depressed mice induced by chronic unpredictable stress. / 12.2017 / PubMed / Full text
The aminoestrogen prolame increases recognition memory and hippocampal neuronal spine density in aged mice. / 10.2017 / PubMed / Full text
The In Vitro Influence of a Genetic Superoxide-Hydrogen Peroxide Imbalance on Immunosenescence. / 08.2017 / PubMed / Full text
Lipid and Alzheimer's disease genes associated with healthy aging and longevity in healthy oldest-old. / 28.03.2017 / PubMed / Full text
Assessing the evolution of redundancy/synergy of spontaneous variability regulation with age. / 05.2017 / PubMed / Full text
Spatially dependent biotic and abiotic factors drive survivorship and physical structure of green roof vegetation. / 01.2017 / PubMed / Full text
Leucine supplementation enhances integrative myofibrillar protein synthesis in free-living older men consuming lower- and higher-protein diets: a parallel-group crossover study. / 12.2016 / PubMed / Full text
Copper accumulation in rodent brain astrocytes: A species difference. / 01.2017 / PubMed / Full text
Age-related individual variability in memory performance is associated with amygdala-hippocampal circuit function and emotional pattern separation. / 01.2017 / PubMed / Full text
Professionals' perspectives towards health promotion in residential aged care: an explorative study in Austria. / 01.04.2018 / PubMed / Full text
Energetics, Biomechanics, and Performance in Masters' Swimmers: A Systematic Review. / 07.2016 / PubMed / Full text
Estrogen-induced neuroprotective and anti-inflammatory effects are dependent on the brain areas of middle-aged female rats. / 06.2016 / PubMed / Full text
Transgenerational programming of longevity and reproduction by post-eclosion dietary manipulation in Drosophila. / 05.2016 / PubMed / Full text
[ENDOSCOPIC ANATOMY AND MORPHOLOGICAL CHANGES OF THE GASTRODUODENAL JUNCTION IN ULCER OF THE DUODENUM]. / 2015 / PubMed
1,3-Dinitrobenzene neurotoxicity - Passage effect in immortalized astrocytes. / 03.2016 / PubMed / Full text
The neural mechanisms underlying the aging-related enhancement of positive affects: electrophysiological evidences. / 2015 / PubMed / Full text
Flavonoid Chrysin prevents age-related cognitive decline via attenuation of oxidative stress and modulation of BDNF levels in aged mouse brain. / 07.2015 / PubMed / Full text
Post-weaning parental care increases fitness but is not heritable in North American red squirrels. / 06.2015 / PubMed / Full text
Sod1 gene ablation in adult mice leads to physiological changes at the neuromuscular junction similar to changes that occur in old wild-type mice. / 07.2015 / PubMed / Full text
Recent advances in the role of cortisol and metabolic syndrome in age-related degenerative diseases. / 02.2016 / PubMed / Full text
Cathelicidin related antimicrobial peptide, laminin, Toll-like receptors and chemokines levels in experimental hypersensitivity pneumonitis in mice. / 06.2015 / PubMed / Full text
Comparison of inducible nitric oxide synthase activity in pancreatic islets of young and aged rats. / 02.2015 / PubMed / Full text
Hexosamine pathway and (ER) protein quality control. / 04.2015 / PubMed / Full text
Antioxidant activity, delayed aging, and reduced amyloid-β toxicity of methanol extracts of tea seed pomace from Camellia tenuifolia. / 05.11.2014 / PubMed / Full text
The Effects of Linguistic Context on Word Recognition in Noise by Elderly Listeners Using Spanish Sentence Lists (SSL). / 12.2015 / PubMed / Full text
Genetic relationships among traits related to reproduction and growth of Nelore females. / 15.09.2014 / PubMed / Full text
Aging Influence on Gray Matter Structural Associations within the Default Mode Network Utilizing Bayesian Network Modeling. / 2014 / PubMed / Full text
Promoting health in Georgia. / 03.2014 / PubMed / Full text

TFПравить

A preliminary investigation of the contribution of different tenderness factors to beef loin, tri-tip and heel tenderness. / 12.2020 / PubMed / Full text
The transcription factor ZmNAC126 accelerates leaf senescence downstream of the ethylene signalling pathway in maize. / 09.2020 / PubMed / Full text
Extensive transcriptome changes during seasonal leaf senescence in field-grown black cottonwood (Populus trichocarpa Nisqually-1). / 20.04.2020 / PubMed / Full text
Expression of Transferrin and Albumin in the Sperm-Storage Tubules of Japanese Quail and their Possible Involvement in Long-Term Sperm Storage. / 25.01.2020 / PubMed / Full text
OsWRKY5 Promotes Rice Leaf Senescence via Senescence-Associated NAC and Abscisic Acid Biosynthesis Pathway. / 09.09.2019 / PubMed / Full text
BrTCP7 Transcription Factor Is Associated with MeJA-Promoted Leaf Senescence by Activating the Expression of [i]BrOPR3[/i] and [i]BrRCCR[/i]. / 14.08.2019 / PubMed / Full text
Activation of the Transcription of [i]BrGA20ox3[/i] by a BrTCP21 Transcription Factor Is Associated with Gibberellin-Delayed Leaf Senescence in Chinese Flowering Cabbage during Storage. / 08.08.2019 / PubMed / Full text
Anti-aging effects of long-term space missions, estimated by heart rate variability. / 20.06.2019 / PubMed / Full text
Transgenic expression of rice MYB102 (OsMYB102) delays leaf senescence and decreases abiotic stress tolerance in Arabidopsis thaliana. / 11.2019 / PubMed / Full text
Tomato fruit ripening factor NOR controls leaf senescence. / 09.05.2019 / PubMed / Full text
The WRKY transcription factor GhWRKY27 coordinates the senescence regulatory pathway in upland cotton (Gossypium hirsutum L.). / 29.03.2019 / PubMed / Full text
Effects of cerium oxide nanoparticles on hemostasis: Coagulation, platelets, and vascular endothelial cells. / 07.2019 / PubMed / Full text
Rice transcription factor OsMYB102 delays leaf senescence by down-regulating abscisic acid accumulation and signaling. / 09.05.2019 / PubMed / Full text
Identification of key genes and transcription factors in aging mesenchymal stem cells by DNA microarray data. / 15.04.2019 / PubMed / Full text
Bioinformatic Analysis Reveals Key Genes and Pathways in Aging Brain of Senescence-accelerated Mouse P8 (SAMP8). / 2018 / PubMed / Full text
Cardiac regenerative capacity is age- and disease-dependent in childhood heart disease. / 2018 / PubMed / Full text
Comparing palm oil tocotrienol rich fraction with α-tocopherol supplementation on oxidative stress in healthy older adults. / 10.2017 / PubMed / Full text
The endothelial tumor suppressor p53 is essential for venous thrombus formation in aged mice. / 12.06.2018 / PubMed / Full text
Comparing Palm Oil, Tocotrienol-Rich Fraction and α-Tocopherol Supplementation on the Antioxidant Levels of Older Adults. / 28.05.2018 / PubMed / Full text
Improved synaptic and cognitive function in aged 3 × Tg-AD mice with reduced amyloid-β after immunotherapy with a novel recombinant 6Aβ15-TF chimeric vaccine. / 08.2018 / PubMed / Full text
Zbtb20 Regulates Developmental Neurogenesis in the Olfactory Bulb and Gliogenesis After Adult Brain Injury. / 01.2019 / PubMed / Full text
Molecular and functional characterization of ShNAC1, an NAC transcription factor from Solanum habrochaites. / 06.2018 / PubMed / Full text
Characterization of a Transcriptional Regulator, BrWRKY6, Associated with Gibberellin-Suppressed Leaf Senescence of Chinese Flowering Cabbage. / 28.02.2018 / PubMed / Full text
Global mapping of transcription factor motifs in human aging. / 2018 / PubMed / Full text
MicroRNAs Regulate Thymic Epithelium in Age-Related Thymic Involution via Down- or Upregulation of Transcription Factors. / 2017 / PubMed / Full text
Cell reprogramming: Therapeutic potential and the promise of rejuvenation for the aging brain. / 11.2017 / PubMed / Full text
BrWRKY65, a WRKY Transcription Factor, Is Involved in Regulating Three Leaf Senescence-Associated Genes in Chinese Flowering Cabbage. / 08.06.2017 / PubMed / Full text
Replicative senescence promotes prothrombotic responses in endothelial cells: Role of NADPH oxidase- and cyclooxygenase-derived oxidative stress. / 07.2017 / PubMed / Full text
Senescence of Pancreas in Middle-Aged Rats with Normal Vascular Function. / 31.03.2017 / PubMed / Full text
Distinct Cell Stress Responses Induced by ATP Restriction in Quiescent Human Fibroblasts. / 2016 / PubMed / Full text
Age-Related Changes in Segmental Body Composition by Ethnicity and History of Weight Change across the Adult Lifespan. / 13.08.2016 / PubMed / Full text
Activation of Nrf2 contributes to the protective effect of Exendin-4 against angiotensin II-induced vascular smooth muscle cell senescence. / 01.10.2016 / PubMed / Full text
Network and biosignature analysis for the integration of transcriptomic and metabolomic data to characterize leaf senescence process in sunflower. / 06.06.2016 / PubMed / Full text
Severity and pattern of bone mineral loss in endocrine causes of osteoporosis as compared to age-related bone mineral loss. / 07-09.2016 / PubMed / Full text
Nitrogen remobilization and conservation, and underlying senescence-associated gene expression in the perennial switchgrass Panicum virgatum. / 07.2016 / PubMed / Full text
Rice ONAC106 Inhibits Leaf Senescence and Increases Salt Tolerance and Tiller Angle. / 12.2015 / PubMed / Full text
Age-related morphologic changes of the vertebral artery in the transverse process. Analysis by multidetector computed tomography angiography. / 01.09.2015 / PubMed / Full text
Different pools of glutamate receptors mediate sensitivity to ambient glutamate in the cochlear nucleus. / 01.06.2015 / PubMed / Full text
Transcriptional and epigenetic regulation of autophagy in aging. / 2015 / PubMed / Full text
Regenerative Medicine for the Aging Brain. / 2014 / PubMed / Full text
Ultrafine carbon particle mediated cardiovascular impairment of aged spontaneously hypertensive rats. / 17.09.2014 / PubMed / Full text
RUNX1, a transcription factor mutated in breast cancer, controls the fate of ER-positive mammary luminal cells. / 21.11.2014 / PubMed / Full text
Epigenetic regulation of tissue factor inducibility in endothelial cell senescence. / 09.2014 / PubMed / Full text
The prognosis of dysphagia patients over 100 years old. / 09-10.2014 / PubMed / Full text
Gene regulatory cascade of senescence-associated NAC transcription factors activated by ETHYLENE-INSENSITIVE2-mediated leaf senescence signalling in Arabidopsis. / 07.2014 / PubMed / Full text

FEVПравить

Prediction of Lung Function in Adolescence Using Epigenetic Aging: A Machine Learning Approach. / 09.11.2020 / PubMed / Full text
Effect of Age on the Efficacy and Safety of Once-Daily Single-Inhaler Triple Therapy Fluticasone Furoate/Umeclidinium/Vilanterol in Patients With Chronic Obstructive Pulmonary Disease: A Post Hoc Analysis of the IMPACT Trial. / 05.10.2020 / PubMed / Full text
A comprehensive analysis of factors related to lung function in older adults: Cross-sectional findings from the Canadian Longitudinal Study on Aging. / 11.2020 / PubMed / Full text
Risk factors associated with the detection of pulmonary emphysema in older asymptomatic respiratory subjects. / 09.06.2020 / PubMed / Full text
Tiotropium Respimat Efficacy and Safety in Asthma: Relationship to Age. / 09.2020 / PubMed / Full text
Current Bronchodilator Responsiveness Criteria Underestimate Asthma in Older Adults. / 08.2020 / PubMed / Full text
Physical performances show conflicting associations in aged manual workers. / 10.02.2020 / PubMed / Full text
FEV as a Standalone Spirometric Predictor and the Attributable Fraction for Death in Older Persons. / 02.2020 / PubMed / Full text
An Individualized Prediction Model for Long-term Lung Function Trajectory and Risk of COPD in the General Population. / 03.2020 / PubMed / Full text
Telomere length and lung function in a population-based cohort of children and mid-life adults. / 12.2019 / PubMed / Full text
Rate of normal lung function decline in ageing adults: a systematic review of prospective cohort studies. / 27.06.2019 / PubMed / Full text
The moderating effect of childhood disadvantage on the associations between smoking and occupational exposure and lung function; a cross sectional analysis of the UK Household Longitudinal Study (UKHLS). / 04.06.2019 / PubMed / Full text
Occupational exposure to solvents and lung function decline: A population based study. / 07.2019 / PubMed / Full text
Disease-Specific Comorbidity Clusters in COPD and Accelerated Aging. / 14.04.2019 / PubMed / Full text
The Effect of the Stretch-Shortening Cycle in the Force-Velocity Relationship and Its Association With Physical Function in Older Adults With COPD. / 2019 / PubMed / Full text
Socioeconomic status and pulmonary function, transition from childhood to adulthood: cross-sectional results from the polish part of the HAPIEE study. / 09.01.2019 / PubMed / Full text
Benefits of improved air quality on ageing lungs: impacts of genetics and obesity. / 04.2019 / PubMed / Full text
The Effects of Aging on Exhaled Nitric Oxide (FeNO) in a North African Population. / 02.2019 / PubMed / Full text
Exogenous female sex steroids may reduce lung ageing after menopause: A 20-year follow-up study of a general population sample (ECRHS). / 02.2019 / PubMed / Full text
Metastable DNA methylation sites associated with longitudinal lung function decline and aging in humans: an epigenome-wide study in the NAS and KORA cohorts. / 2018 / PubMed / Full text
Contribution of peripheral airway function to changes in FEV /FVC and RV/TLC with aging. / 01.11.2018 / PubMed / Full text
Movement behaviours are associated with lung function in middle-aged and older adults: a cross-sectional analysis of the Canadian longitudinal study on aging. / 03.07.2018 / PubMed / Full text
Relationship between pulmonary function and peripheral vascular function in older Chinese: Guangzhou biobank cohort study-CVD. / 21.05.2018 / PubMed / Full text
The role of air pollution and lung function in cognitive impairment. / 02.2018 / PubMed / Full text
Heterogeneous pattern of differences in respiratory parameters between elderly with either good or poor FEV . / 06.02.2018 / PubMed / Full text
Longitudinal assessment of lung function in extremely prematurely born children. / 03.2018 / PubMed / Full text
Older women exhibit greater airway 8-isoprostane responses to strenuous exercise compared with older men and younger controls. / 05.2018 / PubMed / Full text
The association between leisure-time physical activity and lung function in older adults: The English longitudinal study of ageing. / 01.2018 / PubMed / Full text
Spirometry reference values for an andean high-altitude population. / 01.2018 / PubMed / Full text
Consumption of fruit and vegetables might mitigate the adverse effects of ambient PM on lung function among adults. / 01.2018 / PubMed / Full text
Comparative Clinical, Physiological, and Inflammatory Characteristics of Elderly Subjects With or Without Asthma and Young Subjects With Asthma. / 12.2017 / PubMed / Full text
"Spirometric" lung age reference equations: A narrative review. / 01.2018 / PubMed / Full text
Aging and extrapulmonary effects of chronic obstructive pulmonary disease. / 2017 / PubMed / Full text
Prognostic value of short-term decline of forced expiratory volume in 1 s over height cubed (FEV /Ht ) in a cohort of adults aged 80 and over. / 05.2018 / PubMed / Full text
Relationship between lung function and grip strength in older hospitalized patients: a pilot study. / 2017 / PubMed / Full text
[The role of spirometry in encouraging smoking cessation in general practice. A pilot study using "lung age"]. / 09.2017 / PubMed / Full text
Development, Validity and Reliability of the Londrina Activities of Daily Living Protocol for Subjects With COPD. / 03.2017 / PubMed / Full text
Airway wall thickness on HRCT scans decreases with age and increases with smoking. / 01.02.2017 / PubMed / Full text
Menopause Is Associated with Accelerated Lung Function Decline. / 15.04.2017 / PubMed / Full text
Predictive Value of Different Expressions of Forced Expiratory Volume in 1 Second (FEV1) for Adverse Outcomes in a Cohort of Adults Aged 80 and Older. / 01.02.2017 / PubMed / Full text
Effect of aging on sputum inflammation and asthma control. / 06.2017 / PubMed / Full text
Age and Small Airway Imaging Abnormalities in Subjects with and without Airflow Obstruction in SPIROMICS. / 15.02.2017 / PubMed / Full text
Dyspnea in Community-Dwelling Older Persons: A Multifactorial Geriatric Health Condition. / 10.2016 / PubMed / Full text
Novel equations better predict lung age: a retrospective analysis using two cohorts of participants with medical check-up examinations in Japan. / 19.03.2015 / PubMed / Full text

IGF1Править

Genetic differences and longevity-related phenotypes influence lifespan and lifespan variation in a sex-specific manner in mice. / 11.2020 / PubMed / Full text
17α-estradiol modulates IGF1 and hepatic gene expression in a sex-specific manner. / 28.08.2020 / PubMed / Full text
Pan-mammalian analysis of molecular constraints underlying extended lifespan. / 11.02.2020 / PubMed / Full text
17α-Estradiol promotes ovarian aging in growth hormone receptor knockout mice, but not wild-type littermates. / 01.2020 / PubMed / Full text
Reducing INS-IGF1 signaling protects against non-cell autonomous vesicle rupture caused by SNCA spreading. / 05.2020 / PubMed / Full text
Are There Common Mechanisms Between the Hutchinson-Gilford Progeria Syndrome and Natural Aging? / 2019 / PubMed / Full text
Lactoferrin ameliorates aging-suppressed osteogenesis via IGF1 signaling. / 07.2019 / PubMed / Full text
[i]TP53[/i] Tumor-suppressor Gene Plays a Key Role in IGF1 Signaling Pathway Related to the Aging of Human Melanocytes. / 05.2019 / PubMed / Full text
Involvement of insulin receptor substrates in cognitive impairment and Alzheimer's disease. / 08.2019 / PubMed / Full text
In mice transgenic for IGF1 under keratin-14 promoter, lifespan is decreased and the rates of aging and thymus involution are accelerated. / 13.04.2019 / PubMed / Full text
IGF1 Gene Therapy Modifies Microglia in the Striatum of Senile Rats. / 2019 / PubMed / Full text
Novel biomolecules of ageing, sex differences and potential underlying mechanisms of telomere shortening in coronary artery disease. / 05.2019 / PubMed / Full text
Growth signaling and longevity in mouse models. / 01.2019 / PubMed / Full text
IGF-1 Gene Therapy as a Potentially Useful Therapy for Spontaneous Prolactinomas in Senile Rats. / 2018 / PubMed / Full text
A framework for selection of blood-based biomarkers for geroscience-guided clinical trials: report from the TAME Biomarkers Workgroup. / 12.2018 / PubMed / Full text
Matrine induces senescence of human glioblastoma cells through suppression of the IGF1/PI3K/AKT/p27 signaling pathway. / 09.2018 / PubMed / Full text
Composition and richness of the serum microbiome differ by age and link to systemic inflammation. / 06.2018 / PubMed / Full text
40 YEARS of IGF1: IGF1: the Jekyll and Hyde of the aging brain. / 07.2018 / PubMed / Full text
De-silencing [i]Grb10[/i] contributes to acute ER stress-induced steatosis in mouse liver. / 05.2018 / PubMed / Full text
Long-lived rodents reveal signatures of positive selection in genes associated with lifespan. / 03.2018 / PubMed / Full text
Activation of DAF-16/FOXO by reactive oxygen species contributes to longevity in long-lived mitochondrial mutants in Caenorhabditis elegans. / 03.2018 / PubMed / Full text
Withanolide A extends the lifespan in human EGFR-driven cancerous Caenorhabditis elegans. / 04.2018 / PubMed / Full text
Caloric restriction stabilizes body weight and accelerates behavioral recovery in aged rats after focal ischemia. / 12.2017 / PubMed / Full text
Molecular signatures of longevity: Insights from cross-species comparative studies. / 10.2017 / PubMed / Full text
The Ubiquitin Ligase CHIP Integrates Proteostasis and Aging by Regulation of Insulin Receptor Turnover. / 20.04.2017 / PubMed / Full text
Life-span Extension With Reduced Somatotrophic Signaling: Moderation of Aging Effect by Signal Type, Sex, and Experimental Cohort. / 09.11.2017 / PubMed / Full text
Insulin-Like Growth Factor 1: At the Crossroads of Brain Development and Aging. / 2017 / PubMed / Full text
Changes in Communication between Muscle Stem Cells and their Environment with Aging. / 02.09.2015 / PubMed / Full text
Role of Bone Marrow Maturity, Insulin-Like Growth Factor 1 Receptor, and Forkhead Box Protein N1 in Thymic Involution and Rejuvenation. / 10.2016 / PubMed / Full text
Effects of Metabolic Programming on Juvenile Play Behavior and Gene Expression in the Prefrontal Cortex of Rats. / 2016 / PubMed / Full text
Apoptosis during embryonic tissue remodeling is accompanied by cell senescence. / 11.2015 / PubMed / Full text
Telomerase activity promotes osteoblast differentiation by modulating IGF-signaling pathway. / 12.2015 / PubMed / Full text
Exercise does not enhance aged bone's impaired response to artificial loading in C57Bl/6 mice. / 12.2015 / PubMed / Full text
Enhanced memory consolidation in mice lacking the circadian modulators Sharp1 and -2 caused by elevated Igf2 signaling in the cortex. / 07.07.2015 / PubMed / Full text
Aerobic Exercise Recovers Disuse-induced Atrophy Through the Stimulus of the LRP130/PGC-1α Complex in Aged Rats. / 05.2016 / PubMed / Full text
Gene expression of key regulators of mitochondrial biogenesis is sex dependent in mice with growth hormone receptor deletion in liver. / 03.2015 / PubMed / Full text
Insulin-like growth factor 1, glycation and bone fragility: implications for fracture resistance of bone. / 2015 / PubMed / Full text
Comparison of rapamycin schedules in mice on high-fat diet. / 2014 / PubMed / Full text
Growth hormone abolishes beneficial effects of calorie restriction in long-lived Ames dwarf mice. / 10.2014 / PubMed / Full text
A randomised controlled trial evaluating IGF1 titration in contrast to current GH dosing strategies in children born small for gestational age: the North European Small-for-Gestational-Age Study. / 10.2014 / PubMed / Full text
Human IGF1 regulates midgut oxidative stress and epithelial homeostasis to balance lifespan and Plasmodium falciparum resistance in Anopheles stephensi. / 06.2014 / PubMed / Full text
Could different treatment approaches in acromegaly influence life expectancy? A comparative study between Bulgaria and Campania (Italy). / 08.2014 / PubMed / Full text
Insulin and insulin-like growth factor receptors in the brain: physiological and pathological aspects. / 12.2014 / PubMed / Full text
Selective manipulation of aging: a novel strategy for the treatment of neurodegenerative disorders. / 13.02.2014 / PubMed / Full text

CD34Править

Comparing the Effect of TGF-β Receptor Inhibition on Human Perivascular Mesenchymal Stromal Cells Derived from Endometrium, Bone Marrow and Adipose Tissues. / 01.12.2020 / PubMed / Full text
ACE2/ACE imbalance and impaired vasoreparative functions of stem/progenitor cells in aging. / 27.11.2020 / PubMed / Full text
Innovative Mind-Body Intervention Day Easy Exercise Increases Peripheral Blood CD34 Cells in Adults. / 01-12.2020 / PubMed / Full text
Human Thymic Involution and Aging in Humanized Mice. / 2020 / PubMed / Full text
Coinhibition of activated p38 MAPKα and mTORC1 potentiates stemness maintenance of HSCs from SR1-expanded human cord blood CD34 cells via inhibition of senescence. / 12.2020 / PubMed / Full text
Bulk and single-cell gene expression analyses reveal aging human choriocapillaris has pro-inflammatory phenotype. / 09.2020 / PubMed / Full text
Mesenchymal stem cells repair bone marrow damage of aging rats and regulate autophagy and aging genes. / 08.2020 / PubMed / Full text
Immune cell extracellular vesicles and their mitochondrial content decline with ageing. / 2020 / PubMed / Full text
Young and elderly oral squamous cell carcinoma patients present similar angiogenic profile and predominance of M2 macrophages: Comparative immunohistochemical study. / 12.2019 / PubMed / Full text
HIV-mediated immune aging in young adults infected perinatally or during childhood. / 01.09.2019 / PubMed / Full text
Immunophenotypic characterization, multi-lineage differentiation and aging of zebrafish heart and liver tissue-derived mesenchymal stem cells as a novel approach in stem cell-based therapy. / 04.2019 / PubMed / Full text
Cardio-ankle vascular index and circulating CD34-positive cell levels as indicators of endothelial repair activity in older Japanese men. / 06.2019 / PubMed / Full text
Role of apoptotic, autophagic and senescence pathways in minor salivary gland adenoid cystic carcinoma. / 08.02.2019 / PubMed / Full text
Dynamic regulation of NOTCH1 activation and Notch ligand expression in human thymus development. / 13.08.2018 / PubMed / Full text
Therapeutic efficacy of olfactory stem cells in rotenone induced Parkinsonism in adult male albino rats. / 07.2018 / PubMed / Full text
Gender and age-related cell compositional differences in C57BL/6 murine adipose tissue stromal vascular fraction. / 2018 / PubMed / Full text
Endothelial progenitor cells from aged subjects display decreased expression of sirtuin 1, angiogenic functions, and increased senescence. / 09.2018 / PubMed / Full text
Precise Intradermal Injection of Nanofat-Derived Stromal Cells Combined with Platelet-Rich Fibrin Improves the Efficacy of Facial Skin Rejuvenation. / 2018 / PubMed / Full text
Human nail stem cells are retained but hypofunctional during aging. / 06.2018 / PubMed / Full text
Hair Follicle Stem Cell Faith Is Dependent on Chromatin Remodeling Capacity Following Low-Dose Radiation. / 04.2018 / PubMed / Full text
Developmental differences between neonatal and adult human erythropoiesis. / 08.2018 / PubMed / Full text
Normal variation of bone marrow B-cell precursors according to age - reference ranges for studies in myelodysplastic syndromes in Brazil. / 09.2018 / PubMed / Full text
Aging process, adherence to Mediterranean diet and nutritional status in a large cohort of nonagenarians: Effects on endothelial progenitor cells. / 01.2018 / PubMed / Full text
Lower resting and exercise-induced circulating angiogenic progenitors and angiogenic T cells in older men. / 01.03.2018 / PubMed / Full text
HIV-1 p55-gag protein induces senescence of human bone marrow mesenchymal stem cells and reduces their capacity to support expansion of hematopoietic stem cells in vitro. / 09.2017 / PubMed / Full text
SOX17 Regulates Conversion of Human Fibroblasts Into Endothelial Cells and Erythroblasts by Dedifferentiation Into CD34 Progenitor Cells. / 20.06.2017 / PubMed / Full text
Platelets and circulating CD34-positive cells as an indicator of the activity of the vicious cycle between hypertension and endothelial dysfunction in elderly Japanese men. / 04.2017 / PubMed / Full text
Factors that may influence polymorphous low-grade adenocarcinoma growth. / 04.2017 / PubMed / Full text
Age-dependent cellular reactions of the human immune system of humanized NOD scid gamma mice on LPS stimulus. / 04.2017 / PubMed / Full text
Telomere Shortening, Regenerative Capacity, and Cardiovascular Outcomes. / 31.03.2017 / PubMed / Full text
Exercise restores muscle stem cell mobilization, regenerative capacity and muscle metabolic alterations via adiponectin/AdipoR1 activation in SAMP10 mice. / 06.2017 / PubMed / Full text
Expression Analysis of the Stem Cell Marker Pw1/Peg3 Reveals a CD34 Negative Progenitor Population in the Hair Follicle. / 04.2017 / PubMed / Full text
Age-Related Renal Microvascular Changes: Evaluation by Three-Dimensional Digital Imaging of the Human Renal Microcirculation Using Virtual Microscopy. / 02.11.2016 / PubMed / Full text
Constitutive Expression of Inducible Cyclic Adenosine Monophosphate Early Repressor (ICER) in Cycling Quiescent Hematopoietic Cells: Implications for Aging Hematopoietic Stem Cells. / 02.2017 / PubMed / Full text
Age and Human Regenerative Capacity Impact of Cardiovascular Risk Factors. / 16.09.2016 / PubMed / Full text
Endothelial Progenitor Cell Levels Predict Future Physical Function: An Exploratory Analysis From the VA Enhanced Fitness Study. / 03.2016 / PubMed / Full text
Renal resistive index correlates with peritubular capillary loss and arteriosclerosis in biopsy tissues from patients with chronic kidney disease. / 12.2015 / PubMed / Full text
The Mechanism of Ligamentum Flavum Hypertrophy: Introducing Angiogenesis as a Critical Link That Couples Mechanical Stress and Hypertrophy. / 08.2015 / PubMed / Full text
Global transcriptional profiling using RNA sequencing and DNA methylation patterns in highly enriched mesenchymal cells from young versus elderly women. / 07.2015 / PubMed / Full text
Quantification of nucleated cells, CD34-positive cells and CFU-GM colonies in single bone marrow samples and bone marrow harvests derived from healthy children. / 05.2014 / PubMed / Full text
Loss of CD34 expression in aging human choriocapillaris endothelial cells. / 2014 / PubMed / Full text

SDSПравить

Semiautomatic morphometric analysis of skeletal muscle obtained by needle biopsy in older adults. / 12.2020 / PubMed / Full text
Effects of late-onset dietary intake of salidroside on insulin/insulin-like growth factor-1 (IGF-1) signaling pathway of the annual fish Nothobranchius guentheri. / 17.08.2020 / PubMed / Full text
Quantification of Insoluble Protein Aggregation in Caenorhabditis elegans during Aging with a Novel Data-Independent Acquisition Workflow. / 07.08.2020 / PubMed / Full text
Skeletal Muscle Myofibrillar Protein Abundance Is Higher in Resistance-Trained Men, and Aging in the Absence of Training May Have an Opposite Effect. / 10.01.2020 / PubMed / Full text
Characterization, evaluation of nutritional parameters of Radix isatidis protein and its antioxidant activity in D-galactose induced ageing mice. / 06.11.2019 / PubMed / Full text
[Effects of silver nanoparticles on pupation, eclosion, life span, apoptosis and protein expression in Drosophila melanogaster]. / 10.2019 / PubMed / Full text
Does an Age-Specific Treatment Program Augment the Efficacy of a Cognitive-Behavioral Weight Loss Program in Adolescence and Young Adulthood? Results from a Controlled Study. / 02.09.2019 / PubMed / Full text
Strengths and limitations of Bacillus thuringiensis galleriae for managing Japanese beetle (Popillia japonica) adults and grubs with caveats for cross-order activity to monarch butterfly (Danaus plexippus) larvae. / 02.2020 / PubMed / Full text
3-Hydroxykynurenine bound to eye lens proteins induces oxidative modifications in crystalline proteins through a type I photosensitizing mechanism. / 09.2019 / PubMed / Full text
Recombinant Buckwheat Trypsin Inhibitor Improves the Protein and Mitochondria Homeostasis in Caenorhabditis elegans Model of Aging and Age-Related Disease. / 2019 / PubMed / Full text
Potential pitfalls in analyzing structural uncoupling of eNOS: aging is not associated with increased enzyme monomerization. / 01.01.2019 / PubMed / Full text
A 2-year longitudinal study of the relationship between masticatory function and progression to frailty or pre-frailty among community-dwelling Japanese aged 65 and older. / 11.2018 / PubMed / Full text
New findings on SNP variants of human protein L-isoaspartyl methyltransferase that affect catalytic activity, thermal stability, and aggregation. / 2018 / PubMed / Full text
Striatal Mutant Huntingtin Protein Levels Decline with Age in Homozygous Huntington's Disease Knock-In Mouse Models. / 2018 / PubMed / Full text
Proteomic changes during adult stage in pre-optic, hypothalamus, hippocampus and pituitary regions of female rat brain following neonatal exposure to estradiol-17β. / 15.09.2018 / PubMed / Full text
Cheap labor: myosin fiber type expression and enzyme activity in the forelimb musculature of sloths (Pilosa: Xenarthra). / 01.09.2018 / PubMed / Full text
Psychometric Evaluation of the Symptoms of Dementia Screener (SDS) in a Geriatric Primary Care Population. / 10-12.2019 / PubMed / Full text
The Aggravation of Depression with Aging in Japanese Patients with Subacute Myelo-optico-neuropathy (SMON). / 15.08.2017 / PubMed / Full text
Age-independent anti-Müllerian hormone (AMH) standard deviation scores to estimate ovarian function. / 06.2017 / PubMed / Full text
Feeding recombinant E. coli with GST-mBmKTX fusion protein increases the fecundity and lifespan of Caenorhabditis elegans. / 03.2017 / PubMed / Full text
Adult height of preterm infants: a longitudinal cohort study. / 06.2017 / PubMed / Full text
A Large Genome-Wide Association Study of Age-Related Hearing Impairment Using Electronic Health Records. / 10.2016 / PubMed / Full text
Absence of morphological and molecular correlates of sarcopenia in the macaque tongue muscle styloglossus. / 11.2016 / PubMed / Full text
Benchmarking of protein carbonylation analysis in Caenorhabditis elegans: specific considerations and general advice. / 10.2016 / PubMed / Full text
Increased levels of hyper-stable protein aggregates in plasma of older adults. / 06.2016 / PubMed / Full text
Marination and Physicochemical Characteristics of Vacuum-aged Duck Breast Meat. / 11.2016 / PubMed / Full text
The Effect of Aging and the High-Frequency Auditory Threshold on Speech-Evoked Mismatch Negativity in a Noisy Background. / 2016 / PubMed / Full text
Proteomics of the red blood cell carbonylome during blood banking of erythrocyte concentrates. / 03.2016 / PubMed / Full text
Anti-amyloid compounds protect from silica nanoparticle-induced neurotoxicity in the nematode C. elegans. / 2016 / PubMed / Full text
Changes in serum and urine SAA concentrations and qualitative and quantitative proteinuria in Abyssinian cats with familial amyloidosis: a five-year longitudinal study (2009-2014). / 03-04.2015 / PubMed / Full text
The relation of peripubertal and pubertal growth to final adult height in children with classic congenital adrenal hyperplasia. / 03.2015 / PubMed / Full text
Pathology and function of nuclear amyloid. Protein homeostasis matters. / 07-08.2014 / PubMed / Full text
daf-31 encodes the catalytic subunit of N alpha-acetyltransferase that regulates Caenorhabditis elegans development, metabolism and adult lifespan. / 10.2014 / PubMed / Full text
The intramuscular glucagon stimulation test does not provide good discrimination between normal and inadequate ACTH reserve when used in the investigation of short healthy children. / 2014 / PubMed / Full text
Changes in meat quality traits and sarcoplasmic proteins during aging in three different cattle breeds. / 10.2014 / PubMed / Full text
Dysfunctional lipoproteins from young smokers exacerbate cellular senescence and atherogenesis with smaller particle size and severe oxidation and glycation. / 07.2014 / PubMed / Full text
Effect of pH and postmortem aging on protein extraction from broiler breast muscle. / 07.2014 / PubMed / Full text
Age and SPARC change the extracellular matrix composition of the left ventricle. / 2014 / PubMed / Full text
Comprehensive evaluation of androgen replacement therapy in aging Japanese men with late-onset hypogonadism. / 06.2014 / PubMed / Full text
Multilevel, cross-sectional study on social capital with psychogeriatric health among older Japanese people dwelling in rural areas. / 09.2014 / PubMed / Full text
Reliability and validity of the korean version of the lifespan sibling relationship scale. / 12.2013 / PubMed / Full text

TP53Править

p53 inhibits the osteogenic differentiation but does not induce senescence in human dental follicle cells. / 07-08.2020 / PubMed / Full text
Mutational spectrum and dynamics of clonal hematopoiesis in anemia of older individuals. / 02.04.2020 / PubMed / Full text
TP53/miR-34a-associated signaling targets [i]SERPINE1[/i] expression in human pancreatic cancer. / 27.01.2020 / PubMed / Full text
Expression of p16 in nodular fasciitis: an implication for self-limited and inflammatory nature of the lesion. / 2019 / PubMed / Full text
Ultra-Sensitive TP53 Sequencing for Cancer Detection Reveals Progressive Clonal Selection in Normal Tissue over a Century of Human Lifespan. / 02.07.2019 / PubMed / Full text
Collaboration of MYC and RUNX2 in lymphoma simulates T-cell receptor signaling and attenuates p53 pathway activity. / 10.2019 / PubMed / Full text
mTOR Signaling Pathway Regulates Sperm Quality in Older Men. / 21.06.2019 / PubMed / Full text
[i]TP53[/i] Tumor-suppressor Gene Plays a Key Role in IGF1 Signaling Pathway Related to the Aging of Human Melanocytes. / 05.2019 / PubMed / Full text
Distinct cellular responses to replication stress leading to apoptosis or senescence. / 05.2019 / PubMed / Full text
Somatic genome alterations in relation to age in lung adenocarcinoma. / 15.10.2019 / PubMed / Full text
Predictors of disease aggressiveness influence outcome from immunotherapy treatment in renal clear cell carcinoma. / 2019 / PubMed / Full text
Adipose TSHB in Humans and Serum TSH in Hypothyroid Rats Inform About Cellular Senescence. / 2018 / PubMed / Full text
Breast cancer survival predicted by TP53 mutation status differs markedly depending on treatment. / 01.10.2018 / PubMed / Full text
Defective autophagy in vascular smooth muscle cells enhances cell death and atherosclerosis. / 2018 / PubMed / Full text
Detection of a novel, primate-specific 'kill switch' tumor suppression mechanism that may fundamentally control cancer risk in humans: an unexpected twist in the basic biology of TP53. / 11.2018 / PubMed / Full text
Human electronegative LDL induces mitochondrial dysfunction and premature senescence of vascular cells in vivo. / 08.2018 / PubMed / Full text
Troponin T3 associates with DNA consensus sequence that overlaps with p53 binding motifs. / 15.07.2018 / PubMed / Full text
The genetic component of human longevity: New insights from the analysis of pathway-based SNP-SNP interactions. / 06.2018 / PubMed / Full text
Identification of human age-associated gene co-expressions in functional modules using liquid association. / 02.01.2018 / PubMed / Full text
Genetic interrogation of replicative senescence uncovers a dual role for USP28 in coordinating the p53 and GATA4 branches of the senescence program. / 01.10.2017 / PubMed / Full text
A lowered 26S proteasome activity correlates with mantle lymphoma cell lines resistance to genotoxic stress. / 10.08.2017 / PubMed / Full text
Molecular evolutionary patterns of NAD /Sirtuin aging signaling pathway across taxa. / 2017 / PubMed / Full text
A Multigene Test Could Cost-Effectively Help Extend Life Expectancy for Women at Risk of Hereditary Breast Cancer. / 04.2017 / PubMed / Full text
Comprehensive Analysis of Interaction Networks of Telomerase Reverse Transcriptase with Multiple Bioinformatic Approaches: Deep Mining the Potential Functions of Telomere and Telomerase. / 08.2017 / PubMed / Full text
Establishment and application of a novel patient-derived KIAA1549:BRAF-driven pediatric pilocytic astrocytoma model for preclinical drug testing. / 14.02.2017 / PubMed / Full text
Roles of TP53 in determining therapeutic sensitivity, growth, cellular senescence, invasion and metastasis. / 01.2017 / PubMed / Full text
Phosphorylation of MITF by AKT affects its downstream targets and causes TP53-dependent cell senescence. / 11.2016 / PubMed / Full text
Mutational load and mutational patterns in relation to age in head and neck cancer. / 25.10.2016 / PubMed / Full text
GBM-associated mutations and altered protein expression are more common in young patients. / 25.10.2016 / PubMed / Full text
rs78378222 polymorphism in the 3'-untranslated region of TP53 contributes to development of age-associated cataracts by modifying microRNA-125b-induced apoptosis of lens epithelial cells. / 09.2016 / PubMed / Full text
Evasion of cell senescence in SHH medulloblastoma. / 17.08.2016 / PubMed / Full text
Candidate gene resequencing to identify rare, pedigree-specific variants influencing healthy aging phenotypes in the long life family study. / 09.04.2016 / PubMed / Full text
Induction of DNA double-strand breaks and cellular senescence by human respiratory syncytial virus. / 18.05.2016 / PubMed / Full text
Targeting genes in insulin-associated signalling pathway, DNA damage, cell proliferation and cell differentiation pathways by tocotrienol-rich fraction in preventing cellular senescence of human diploid fibroblasts. / 11-12.2015 / PubMed / Full text
EBV and not HPV sensitizes tobacco-associated head and neck cancer cell line FaDu to radiotherapy. / 2016 / PubMed / Full text
Radiation promotes colorectal cancer initiation and progression by inducing senescence-associated inflammatory responses. / 30.06.2016 / PubMed / Full text
The different radiation response and radiation-induced bystander effects in colorectal carcinoma cells differing in p53 status. / 08.2015 / PubMed / Full text
Epigenetic Aging Signatures Are Coherently Modified in Cancer. / 06.2015 / PubMed / Full text
Solutions to Peto's paradox revealed by mathematical modelling and cross-species cancer gene analysis. / 19.07.2015 / PubMed / Full text
Sensitivity of neoplastic cells to senescence unveiled under standard cell culture conditions. / 05.2015 / PubMed
Human TP53 polymorphism (rs1042522) modelled in mouse does not affect glucose metabolism and body composition. / 13.02.2014 / PubMed / Full text

IVDПравить

MicroRNAs in Intervertebral Disc Degeneration, Apoptosis, Inflammation, and Mechanobiology. / 20.05.2020 / PubMed / Full text
A step-by-step protocol for isolation of murine nucleus pulposus cells. / 12.2019 / PubMed / Full text
Caspase-3 knockout inhibits intervertebral disc degeneration related to injury but accelerates degeneration related to aging. / 18.12.2019 / PubMed / Full text
Finite element and deformation analyses predict pattern of bone failure in loaded zebrafish spines. / 29.11.2019 / PubMed / Full text
Improvement in determining the risk of damage to the human lumbar functional spinal unit considering age, height, weight and sex using a combination of FEM and RSM. / 02.2020 / PubMed / Full text
In vivo contrast-enhanced microCT for the monitoring of mouse thoracic, lumbar, and coccygeal intervertebral discs. / 06.2019 / PubMed / Full text
MicroRNA-143-5p targeting eEF2 gene mediates intervertebral disc degeneration through the AMPK signaling pathway. / 15.04.2019 / PubMed / Full text
Curcumin and o-Vanillin Exhibit Evidence of Senolytic Activity in Human IVD Cells In Vitro. / 29.03.2019 / PubMed / Full text
Aging of mouse intervertebral disc and association with back pain. / 06.2019 / PubMed / Full text
Role of heparan sulfate 6-0 endosulfatases in intervertebral disc homeostasis. / 09.2019 / PubMed / Full text
Evaluation of age-related changes in lumbar facet joints using T2 mapping. / 01.2020 / PubMed / Full text
A histocytological and radiological overview of the natural history of intervertebral disk: from embryonic formation to age-related degeneration. / 04.2019 / PubMed / Full text
Regenerative potential of human nucleus pulposus resident stem/progenitor cells declines with ageing and intervertebral disc degeneration. / 10.2018 / PubMed / Full text
TRPC6 in simulated microgravity of intervertebral disc cells. / 10.2018 / PubMed / Full text
FOXO are required for intervertebral disk homeostasis during aging and their deficiency promotes disk degeneration. / 10.2018 / PubMed / Full text
Major traits of the senescent phenotype of nucleus pulposus intervertebral disc cells persist under the specific microenvironmental conditions of the tissue. / 01.2019 / PubMed / Full text
[Influence analysis of aging of spinal segment on the mechanical behavior of vertebral cortex]. / 01.06.2017 / PubMed / Full text
The adolescent idiopathic scoliotic IVD displays advanced aggrecanolysis and a glycosaminoglycan composition similar to that of aged human and ovine IVDs. / 09.2018 / PubMed / Full text
Costs and benefits of diagnostic testing: four ways to improve patient care by purposive use of in vitro diagnostics. / 2017 / PubMed / Full text
Matrisome Profiling During Intervertebral Disc Development And Ageing. / 14.09.2017 / PubMed / Full text
Age-related decline in AMH is assay dependent limiting clinical interpretation of repeat AMH measures across the reproductive lifespan. / 02.2018 / PubMed / Full text
Notochordal and nucleus pulposus marker expression is maintained by sub-populations of adult human nucleus pulposus cells through aging and degeneration. / 04.05.2017 / PubMed / Full text
Microcalcification of lumbar spine intervertebral discs and facet joints is associated with cartilage degeneration, but differs in prevalence and its relation to age. / 12.2017 / PubMed / Full text
Age-related reduction in the expression of FOXO transcription factors and correlations with intervertebral disc degeneration. / 12.2017 / PubMed / Full text
Correlation of matrix metalloproteinase (MMP)-1, -2, -3, and -9 expressions with demographic and radiological features in primary lumbar intervertebral disc disease. / 07.2017 / PubMed / Full text
3D characterization of morphological changes in the intervertebral disc and endplate during aging: A propagation phase contrast synchrotron micro-tomography study. / 07.03.2017 / PubMed / Full text
Lumbar intervertebral discs T2 relaxometry and T1ρ relaxometry correlation with age in asymptomatic young adults. / 08.2016 / PubMed / Full text
Prevalence of Age-Related Changes in Ovine Lumbar Intervertebral Discs during Computed Tomography and Magnetic Resonance Imaging. / 2016 / PubMed / Full text
The intervertebral disc contains intrinsic circadian clocks that are regulated by age and cytokines and linked to degeneration. / 03.2017 / PubMed / Full text
Disc cell senescence in intervertebral disc degeneration: Causes and molecular pathways. / 02.07.2016 / PubMed / Full text
The aging disc: using an ovine model to examine age-related differences in the biomechanical properties of the intralamellar matrix of single lamellae. / 01.2017 / PubMed / Full text
Molecular mechanisms of cell death in intervertebral disc degeneration (Review). / 06.2016 / PubMed / Full text
Identifying molecular phenotype of nucleus pulposus cells in human intervertebral disc with aging and degeneration. / 08.2016 / PubMed / Full text
Role of SHOX2 in the development of intervertebral disc degeneration. / 05.2017 / PubMed / Full text
Age- and degeneration-related variations in cell density and glycosaminoglycan content in the human cervical intervertebral disc and its endplates. / 09.2015 / PubMed / Full text
Aging and age related stresses: a senescence mechanism of intervertebral disc degeneration. / 03.2016 / PubMed / Full text
Early changes in morphology, bone mineral density and matrix composition of vertebrae lead to disc degeneration in aged collagen IX -/- mice. / 01.2016 / PubMed / Full text
Chronic ingestion of advanced glycation end products induces degenerative spinal changes and hypertrophy in aging pre-diabetic mice. / 2015 / PubMed / Full text
A computational analysis on the implications of age-related changes in the expression of cellular signals on the role of IGF-1 in intervertebral disc homeostasis. / 21.01.2015 / PubMed / Full text
Gene expression analysis in response to osmotic stimuli in the intervertebral disc with DNA microarray. / 27.12.2013 / PubMed / Full text

METПравить

Self-rated health in relation to fruit and vegetable consumption and physical activity among older cancer survivors. / 26.09.2020 / PubMed / Full text
Leisure-time physical activity volume, intensity, and duration from mid- to late-life in U.S. subpopulations by race and sex. The Atherosclerosis Risk In Communities (ARIC) Study. / 13.03.2020 / PubMed / Full text
Repressive H3K9me2 protects lifespan against the transgenerational burden of COMPASS activity in [i]C. elegans[/i]. / 09.12.2019 / PubMed / Full text
Influence of Anthropometrics on Step-Rate Thresholds for Moderate and Vigorous Physical Activity in Older Adults: Scientific Modeling Study. / 13.12.2018 / PubMed / Full text
Physical activity, multimorbidity, and life expectancy: a UK Biobank longitudinal study. / 12.06.2019 / PubMed / Full text
Metformin prevents murine ovarian aging. / 10.06.2019 / PubMed / Full text
Afterword: Oral Methioninase-Answer to Cancer and Fountain of Youth? / 2019 / PubMed / Full text
Leveraging Household Structure for Increasing Adult Physical Activity in a Low-Income, African American Community. / 07.2020 / PubMed / Full text
Appropriate Amount of Regular Exercise Is Associated with a Reduced Mortality Risk. / 12.2018 / PubMed / Full text
The Relationship between Cardiorespiratory Fitness and Montreal Cognitive Assessment Scores in Older Adults. / 2018 / PubMed / Full text
Metabolic adaptation of short-living growth hormone transgenic mice to methionine restriction and supplementation. / 04.2018 / PubMed / Full text
Does the use of outdoor fitness equipment by older adults qualify as moderate to vigorous physical activity? / 2018 / PubMed / Full text
Hypoxia-inducible transcription factors, HIF1A and HIF2A, increase in aging mucosal tissues. / 07.2018 / PubMed / Full text
The metabolic equivalents of one-mile walking by older adults; implications for health promotion. / 2017 / PubMed / Full text
The effect of age on fitness among female firefighters. / 01.10.2017 / PubMed / Full text
Physical Activity in Midlife is not Associated with Cognitive Health in Later Life Among Cognitively Normal Older Adults. / 2017 / PubMed / Full text
Associations Between Self-Reported Physical Activity and Physical Performance Measures Over Time in Postmenopausal Women: The Women's Health Initiative. / 10.2017 / PubMed / Full text
Anti-aging pharmacology in cutaneous wound healing: effects of metformin, resveratrol, and rapamycin by local application. / 10.2017 / PubMed / Full text
Optical properties of the human lens constituents. / 08.2017 / PubMed / Full text
High intensity interval training (HIIT) improves resting blood pressure, metabolic (MET) capacity and heart rate reserve without compromising cardiac function in sedentary aging men. / 08.2018 / PubMed / Full text
Relationship Between Lifelong Exercise Volume and Coronary Atherosclerosis in Athletes. / 11.07.2017 / PubMed / Full text
Physical activity and telomere length in U.S. men and women: An NHANES investigation. / 07.2017 / PubMed / Full text
Glycation inhibitors extend yeast chronological lifespan by reducing advanced glycation end products and by back regulation of proteins involved in mitochondrial respiration. / 06.03.2017 / PubMed / Full text
Testing a Matching Hypothesis for Emerging Adults in Project MATCH: During-Treatment and One-Year Outcomes. / 01.2017 / PubMed / Full text
Non-sedentary Lifestyle Can Reduce Hip Fracture Risk among Older Caucasians Adults: The Adventist Health Study-2. / 2015 / PubMed / Full text
Performance of Older Persons in a Simulated Shopping Task Is Influenced by Priming with Age Stereotypes. / 2016 / PubMed / Full text
Metabolic Equivalent in Adolescents, Active Adults and Pregnant Women. / 20.07.2016 / PubMed / Full text
Motor effort training with low exercise intensity improves muscle strength and descending command in aging. / 06.2016 / PubMed / Full text
Changes in Neural Connectivity and Memory Following a Yoga Intervention for Older Adults: A Pilot Study. / 2016 / PubMed / Full text
Changes in physical activity during transition to retirement: a cohort study. / 16.04.2016 / PubMed / Full text
Accuracy of Direct Observation to Assess Physical Activity in Older Adults. / 10.2016 / PubMed / Full text
Multimorbidity, cognitive function, and physical activity. / 02.2016 / PubMed / Full text
Age-dependent prognostic value of exercise capacity and derivation of fitness-associated biologic age. / 03.2016 / PubMed / Full text
Elderly men with moderate and intense training lifestyle present sustained higher antibody responses to influenza vaccine. / 12.2015 / PubMed / Full text
Age-related microstructural differences quantified using myelin water imaging and advanced diffusion MRI. / 06.2015 / PubMed / Full text
Altered dietary methionine differentially impacts glutathione and methionine metabolism in long-living growth hormone-deficient Ames dwarf and wild-type mice. / 2014 / PubMed / Full text
Diabetes-related distress, insulin dose, and age contribute to insulin-associated weight gain in patients with type 2 diabetes: results of a prospective study. / 10.2014 / PubMed / Full text
A prospective epigenetic paradigm between cellular senescence and epithelial-mesenchymal transition in organismal development and aging. / 01.2015 / PubMed / Full text
Associations of physical exercise as a lifestyle habit with lean and fat body mass and handgrip strength and age in Asian men. / 09.2014 / PubMed / Full text
Exercise capacity and all-cause mortality in male veterans with hypertension aged ≥70 years. / 07.2014 / PubMed / Full text

NHSПравить

Telomerase Activation to Reverse Immunosenescence in Elderly Patients With Acute Coronary Syndrome: Protocol for a Randomized Pilot Trial. / 23.09.2020 / PubMed / Full text
Factors associated with COVID-19-related death using OpenSAFELY. / 08.2020 / PubMed / Full text
Advanced ophthalmic nurse practitioners: the potential to improve outcomes for older people with cataracts. / 17.06.2020 / PubMed / Full text
Patient Satisfaction in the Spanish National Health Service: Partial Least Squares Structural Equation Modeling. / 04.12.2019 / PubMed / Full text
Heart failure with preserved ejection fraction (HFpEF) pathophysiology study (IDENTIFY-HF): does increased arterial stiffness associate with HFpEF, in addition to ageing and vascular effects of comorbidities? Rationale and design. / 19.11.2019 / PubMed / Full text
Challenges to concordance: theories that explain variations in patient responses. / 02.10.2019 / PubMed / Full text
Optimism is associated with exceptional longevity in 2 epidemiologic cohorts of men and women. / 10.09.2019 / PubMed / Full text
Reducing readmission rates through a discharge follow-up service. / 06.2019 / PubMed / Full text
The cost burden of falls in people with glaucoma in National Health Service Hospital Trusts in the UK. / 01.2020 / PubMed / Full text
How Do General Practitioners (GPs) Engage in Falls Prevention With Older People? A Pilot Survey of GPs in NHS England Suggests a Gap in Routine Practice to Address Falls Prevention. / 2019 / PubMed / Full text
Fruit and vegetable consumption, cigarette smoke, and leukocyte mitochondrial DNA copy number. / 01.02.2019 / PubMed / Full text
Where are we now in perioperative medicine? Results from a repeated UK survey of geriatric medicine delivered services for older people. / 01.05.2019 / PubMed / Full text
PATCH: posture and mobility training for care staff versus usual care in care homes: study protocol for a randomised controlled trial. / 24.09.2018 / PubMed / Full text
Predictive model of length of stay in hospital among older patients. / 07.2019 / PubMed / Full text
A qualitative study of the determinants of adherence to NICE falls guideline in managing older fallers attending an emergency department. / 18.07.2018 / PubMed / Full text
Economic evaluations of eHealth technologies: A systematic review. / 2018 / PubMed / Full text
Shifting to triple value healthcare: Reflections from England. / 02.2018 / PubMed / Full text
Is "end of life" a special case? Connecting Q with survey methods to measure societal support for views on the value of life-extending treatments. / 05.2018 / PubMed / Full text
PERFECTED enhanced recovery (PERFECT-ER) care versus standard acute care for patients admitted to acute settings with hip fracture identified as experiencing confusion: study protocol for a feasibility cluster randomized controlled trial. / 04.12.2017 / PubMed / Full text
Exploring the relationship between frequent internet use and health and social care resource use in a community-based cohort of older adults: an observational study in primary care. / 21.07.2017 / PubMed / Full text
Tumor-targeted IL-12 combined with local irradiation leads to systemic tumor control via abscopal effects [i]in vivo[/i]. / 2017 / PubMed / Full text
Long-term survival after traumatic spinal cord injury: a 70-year British study. / 07.2017 / PubMed / Full text
The Community In-reach Rehabilitation and Care Transition (CIRACT) clinical and cost-effectiveness randomisation controlled trial in older people admitted to hospital as an acute medical emergency. / 06.01.2017 / PubMed / Full text
The changing profile of our patients. / 26.01.2017 / PubMed / Full text
FRACTURE LIAISON SERVICES: MULTIDISCIPLINARY APPROACHES TO SECONDARY FRACTURE PREVENTION. / 02.2017 / PubMed / Full text
Dietary flavonoid intake and risk of incident depression in midlife and older women. / 09.2016 / PubMed / Full text
Paramedics' experiences of end-of-life care decision making with regard to nursing home residents: an exploration of influential issues and factors. / 10.2016 / PubMed / Full text
Treatment cost and life expectancy of diffuse large B-cell lymphoma (DLBCL): a discrete event simulation model on a UK population-based observational cohort. / 03.2017 / PubMed / Full text
A personal perspective from the UK: ageing and psychiatrists. / 04.2016 / PubMed / Full text
Developing and validating a risk prediction model for acute care based on frailty syndromes. / 21.10.2015 / PubMed / Full text
CD4( ) T cell surface alpha enolase is lower in older adults. / 12.2015 / PubMed / Full text
Room for one more? A review of the literature on 'inappropriate' admissions to hospital for older people in the English NHS. / 01.2017 / PubMed / Full text
Cancer-targeted IL-12 controls human rhabdomyosarcoma by senescence induction and myogenic differentiation. / 07.2015 / PubMed / Full text
Long-Term Change in Diet Quality Is Associated with Body Weight Change in Men and Women. / 08.2015 / PubMed / Full text
Calculating when elective abdominal aortic aneurysm repair improves survival for individual patients: development of the Aneurysm Repair Decision Aid and economic evaluation. / 04.2015 / PubMed / Full text
Cost-effectiveness analysis of endoscopic ultrasound versus magnetic resonance cholangiopancreatography in patients with suspected common bile duct stones. / 2015 / PubMed / Full text
Methods for the estimation of the National Institute for Health and Care Excellence cost-effectiveness threshold. / 02.2015 / PubMed / Full text
Single screening questions for cognitive impairment in older people: a systematic review. / 03.2015 / PubMed / Full text
Where are we in perioperative medicine for older surgical patients? A UK survey of geriatric medicine delivered services in surgery. / 09.2014 / PubMed / Full text
Swiss quality and outcomes framework: quality indicators for diabetes management in Swiss primary care based on electronic medical records. / 2014 / PubMed / Full text

PINK1Править

Spermidine inhibits neurodegeneration and delays aging via the PINK1-PDR1-dependent mitophagy pathway in [i]C. elegans[/i]. / 09.09.2020 / PubMed / Full text
Female mice are resilient to age-related decline of substantia nigra dopamine neuron firing parameters. / 11.2020 / PubMed / Full text
Attenuation of epigenetic regulator SMARCA4 and ERK-ETS signaling suppresses aging-related dopaminergic degeneration. / 09.2020 / PubMed / Full text
SIRT1 alleviates high-magnitude compression-induced senescence in nucleus pulposus cells via PINK1-dependent mitophagy. / 18.07.2020 / PubMed / Full text
Synergistic action of propolis with levodopa in the management of Parkinsonism in Drosophila melanogaster. / 23.09.2020 / PubMed / Full text
Compression-induced senescence of nucleus pulposus cells by promoting mitophagy activation via the PINK1/PARKIN pathway. / 05.2020 / PubMed / Full text
Doxorubicin-induced normal breast epithelial cellular aging and its related breast cancer growth through mitochondrial autophagy and oxidative stress mitigated by ginsenoside Rh2. / 07.2020 / PubMed / Full text
Mitochondrial DNA heteroplasmy rises in substantial nigra of aged PINK1 KO mice. / 22.01.2020 / PubMed / Full text
Late life maintenance and enhancement of functional exercise capacity in low and high responding rats after low intensity treadmill training. / 01.10.2019 / PubMed / Full text
SerThr-PhosphoProteome of Brain from Aged PINK1-KO A53T-SNCA Mice Reveals pT1928-MAP1B and pS3781-ANK2 Deficits, as Hub between Autophagy and Synapse Changes. / 04.07.2019 / PubMed / Full text
Neuronal Mitophagy: Lessons from a Pathway Linked to Parkinson's Disease. / 08.2019 / PubMed / Full text
Inhibition of the deubiquitinase USP8 corrects a Drosophila PINK1 model of mitochondria dysfunction. / 04.2019 / PubMed / Full text
Oligonol Alleviates Sarcopenia by Regulation of Signaling Pathways Involved in Protein Turnover and Mitochondrial Quality. / 05.2019 / PubMed / Full text
AMP Kinase Activation is Selectively Disrupted in the Ventral Midbrain of Mice Deficient in Parkin or PINK1 Expression. / 03.2019 / PubMed / Full text
Intensified mitophagy in skeletal muscle with aging is downregulated by PGC-1alpha overexpression in vivo. / 01.2019 / PubMed / Full text
Melatonin protects chronic kidney disease mesenchymal stem cells against senescence via PrP -dependent enhancement of the mitochondrial function. / 01.2019 / PubMed / Full text
PRKN-regulated mitophagy and cellular senescence during COPD pathogenesis. / 03.2019 / PubMed / Full text
Grape skin extract improves muscle function and extends lifespan of a Drosophila model of Parkinson's disease through activation of mitophagy. / 11.2018 / PubMed / Full text
Imaging mitophagy in the fruit fly. / 2018 / PubMed / Full text
Age- and disease-dependent increase of the mitophagy marker phospho-ubiquitin in normal aging and Lewy body disease. / 2018 / PubMed / Full text
PINK1 protects against oxidative stress induced senescence of human nucleus pulposus cells via regulating mitophagy. / 02.10.2018 / PubMed / Full text
Deficiency of parkin and PINK1 impairs age-dependent mitophagy in [i]Drosophila[/i]. / 29.05.2018 / PubMed / Full text
ATF3 represses PINK1 gene transcription in lung epithelial cells to control mitochondrial homeostasis. / 04.2018 / PubMed / Full text
In vivo imaging reveals mitophagy independence in the maintenance of axonal mitochondria during normal aging. / 10.2017 / PubMed / Full text
Progression of pathology in PINK1-deficient mouse brain from splicing via ubiquitination, ER stress, and mitophagy changes to neuroinflammation. / 02.08.2017 / PubMed / Full text
The age-associated loss of ischemic preconditioning in the kidney is accompanied by mitochondrial dysfunction, increased protein acetylation and decreased autophagy. / 15.03.2017 / PubMed / Full text
Changes in macroautophagy, chaperone-mediated autophagy, and mitochondrial metabolism in murine skeletal and cardiac muscle during aging. / 26.02.2017 / PubMed / Full text
PINK1 signaling in mitochondrial homeostasis and in aging (Review). / 01.2017 / PubMed / Full text
Involvement of PINK1/Parkin-mediated mitophagy in AGE-induced cardiomyocyte aging. / 15.01.2017 / PubMed / Full text
Identifying potential PARIS homologs in D. melanogaster. / 03.11.2016 / PubMed / Full text
Restoring Pharmacologic Preconditioning in the Aging Heart: Role of Mitophagy/Autophagy. / 01.04.2017 / PubMed / Full text
HSP27 Alleviates Cardiac Aging in Mice via a Mechanism Involving Antioxidation and Mitophagy Activation. / 2016 / PubMed / Full text
Mitochondrial ROS Produced via Reverse Electron Transport Extend Animal Lifespan. / 12.04.2016 / PubMed / Full text
Interfacing mitochondrial biogenesis and elimination to enhance host pathogen defense and longevity. / 07-09.2015 / PubMed / Full text
Deregulation of selective autophagy during aging and pulmonary fibrosis: the role of TGFβ1. / 10.2015 / PubMed / Full text
Mutant alpha-synuclein causes age-dependent neuropathology in monkey brain. / 27.05.2015 / PubMed / Full text
PINK1 deficiency impairs mitochondrial homeostasis and promotes lung fibrosis. / 02.2015 / PubMed / Full text
The degeneration and replacement of dopamine cells in Parkinson's disease: the role of aging. / 2014 / PubMed / Full text
Defective mitophagy in XPA via PARP-1 hyperactivation and NAD( )/SIRT1 reduction. / 08.05.2014 / PubMed / Full text
Antiaging properties of a grape-derived antioxidant are regulated by mitochondrial balance of fusion and fission leading to mitophagy triggered by a signaling network of Sirt1-Sirt3-Foxo3-PINK1-PARKIN. / 2014 / PubMed / Full text

CD27Править

The Interplay between CD27 and CD27 B Cells Ensures the Flexibility, Stability, and Resilience of Human B Cell Memory. / 03.03.2020 / PubMed / Full text
CMV-independent increase in CD27-CD28 CD8 EMRA T cells is inversely related to mortality in octogenarians. / 2020 / PubMed / Full text
Compartmentalized cytotoxic immune response leads to distinct pathogenic roles of natural killer and senescent CD8 T cells in human cutaneous leishmaniasis. / 04.2020 / PubMed / Full text
CD27- IgD- B cell memory subset associates with inflammation and frailty in elderly individuals but only in males. / 2019 / PubMed / Full text
Are skin senescence and immunosenescence linked within individuals? / 08.2019 / PubMed / Full text
Circulating Senescent T Cells Are Linked to Systemic Inflammation and Lesion Size During Human Cutaneous Leishmaniasis. / 2018 / PubMed / Full text
Low IL-2 Expressing T Cells in Thalassemia Major Patients: Is It Immune Aging. / 10.2018 / PubMed / Full text
Senescence markers: Predictive for response to checkpoint inhibitors. / 01.03.2019 / PubMed / Full text
Features of Immunosenescence in Women Newly Diagnosed With Breast Cancer. / 2018 / PubMed / Full text
Age, calorie restriction, and age of calorie restriction onset reduce maturation of natural killer cells in C57Bl/6 mice. / 07.2018 / PubMed / Full text
CD57 identifies T cells with functional senescence before terminal differentiation and relative telomere shortening in patients with activated PI3 kinase delta syndrome. / 11.2018 / PubMed / Full text
An immunological age index in bipolar disorder: A confirmatory factor analysis of putative immunosenescence markers and associations with clinical characteristics. / 12.2018 / PubMed / Full text
Age-associated distribution of normal B-cell and plasma cell subsets in peripheral blood. / 06.2018 / PubMed / Full text
Diminished antibody response to influenza vaccination is characterized by expansion of an age-associated B-cell population with low PAX5. / 08.2018 / PubMed / Full text
Dynamics of CD4 and CD8 T-Cell Subsets and Inflammatory Biomarkers during Early and Chronic HIV Infection in Mozambican Adults. / 2017 / PubMed / Full text
Genetic influence on splenic natural killer cell frequencies and maturation among aged mice. / 04.2018 / PubMed / Full text
Increased senescent CD8 T cells in the peripheral blood mononuclear cells of Behçet's disease patients. / 03.2018 / PubMed / Full text
T-cell differentiation and CD56 levels in polypoidal choroidal vasculopathy and neovascular age-related macular degeneration. / 20.11.2017 / PubMed / Full text
Human CD8 EMRA T cells display a senescence-associated secretory phenotype regulated by p38 MAPK. / 02.2018 / PubMed / Full text
Human IgG2- and IgG4-expressing memory B cells display enhanced molecular and phenotypic signs of maturity and accumulate with age. / 10.2017 / PubMed / Full text
Impact of age and cytomegalovirus on CD8 T-cell compartment remodeling after solid organ transplantation: A one-year follow-up study. / 09.2017 / PubMed / Full text
Lymph node and circulating T cell characteristics are strongly correlated in end-stage renal disease patients, but highly differentiated T cells reside within the circulation. / 05.2017 / PubMed / Full text
Calorie Restriction Attenuates Terminal Differentiation of Immune Cells. / 2016 / PubMed / Full text
Common Variable Immunodeficiency patients with a phenotypic profile of immunosenescence present with thrombocytopenia. / 05.01.2017 / PubMed / Full text
Phenotypic characteristics of aged CD4 CD28 T lymphocytes are determined by changes in the whole-genome DNA methylation pattern. / 04.2017 / PubMed / Full text
Age-Associated B Cells with Proinflammatory Characteristics Are Expanded in a Proportion of Multiple Sclerosis Patients. / 15.12.2016 / PubMed / Full text
Specific phenotype and function of CD56-expressing innate immune cell subsets in human thymus. / 12.2016 / PubMed / Full text
Inflammatory and immune markers associated with physical frailty syndrome: findings from Singapore longitudinal aging studies. / 17.05.2016 / PubMed / Full text
Alteration of T Cell Subtypes in Beta-Thalassaemia Major: Impact of Ferritin Level. / 02.2016 / PubMed / Full text
Genetic Influence on the Peripheral Blood CD4 T-cell Differentiation Status in CMV Infection. / 12.2016 / PubMed / Full text
Age-related profiling of DNA methylation in CD8 T cells reveals changes in immune response and transcriptional regulator genes. / 19.08.2015 / PubMed / Full text
Senescent profile of angiogenic T cells from systemic lupus erythematosus patients. / 03.2016 / PubMed / Full text
Age-related aspects of human IgM( ) B cell heterogeneity. / 12.2015 / PubMed / Full text
The impact of immunosenescence on humoral immune response variation after influenza A/H1N1 vaccination in older subjects. / 2015 / PubMed / Full text
Multifunctional cytomegalovirus (CMV)-specific CD8( ) T cells are not restricted by telomere-related senescence in young or old adults. / 04.2015 / PubMed / Full text
The CD27 memory B cells display changes in the gene expression pattern in elderly individuals. / 06.09.2014 / PubMed / Full text
γ/δ T cell subsets in human aging using the classical α/β T cell model. / 10.2014 / PubMed / Full text
Double negative (CD19 IgG IgD-CD27-) B lymphocytes: a new insight from telomerase in healthy elderly, in centenarian offspring and in Alzheimer's disease patients. / 11.2014 / PubMed / Full text
Impact of HIV on CD8 T cell CD57 expression is distinct from that of CMV and aging. / 2014 / PubMed / Full text

EGFПравить

Acute, exercise-induced alterations in cytokines and chemokines in the blood distinguish physically active and sedentary aging. / 08.12.2020 / PubMed / Full text
Proinflammation, profibrosis, and arterial aging. / 09.2020 / PubMed / Full text
Hinokitiol induces cell death and inhibits epidermal growth factor-induced cell migration and signaling pathways in human cervical adenocarcinoma. / 09.2020 / PubMed / Full text
Activation of epidermal growth factor receptor signaling mediates cellular senescence induced by certain pro-inflammatory cytokines. / 05.2020 / PubMed / Full text
Insulin Signaling in Intestinal Stem and Progenitor Cells as an Important Determinant of Physiological and Metabolic Traits in [i]Drosophila[/i]. / 26.03.2020 / PubMed / Full text
Different cellular properties and loss of nuclear signalling of porcine epidermal growth factor receptor with aging. / 01.05.2020 / PubMed / Full text
Isoform-selective as opposed to complete depletion of fibroblast growth factor 2 (FGF-2) has no major impact on survival and gene expression in SOD1 amyotrophic lateral sclerosis mice. / 09.2019 / PubMed / Full text
A novel age-related venous amyloidosis derived from EGF-containing fibulin-like extracellular matrix protein 1. / 04.2019 / PubMed / Full text
EGF/EGFR upregulates and cooperates with Netrin-4 to protect glioblastoma cells from DNA damage-induced senescence. / 04.12.2018 / PubMed / Full text
Circulating Vascular Growth Factors and Magnetic Resonance Imaging Markers of Small Vessel Disease and Atrophy in Middle-Aged Adults. / 09.2018 / PubMed / Full text
The effects of aging, diabetes mellitus, and antiplatelet drugs on growth factors and anti-aging proteins in platelet-rich plasma. / 2019 / PubMed / Full text
Insulin-like growth factor-1 acts as a zeitgeber on hypothalamic circadian clock gene expression via glycogen synthase kinase-3β signaling. / 02.11.2018 / PubMed / Full text
Burn wounds in the young versus the aged patient display differential immunological responses. / 09.2018 / PubMed / Full text
Precise Intradermal Injection of Nanofat-Derived Stromal Cells Combined with Platelet-Rich Fibrin Improves the Efficacy of Facial Skin Rejuvenation. / 2018 / PubMed / Full text
RPE phagocytic function declines in age-related macular degeneration and is rescued by human umbilical tissue derived cells. / 13.03.2018 / PubMed / Full text
Human amniotic mesenchymal stem cells improve ovarian function in natural aging through secreting hepatocyte growth factor and epidermal growth factor. / 09.03.2018 / PubMed / Full text
VEGF Signaling in Neurological Disorders. / 17.01.2018 / PubMed / Full text
Global analysis of gene expression profiles in the submandibular salivary gland of klotho knockout mice. / 04.2018 / PubMed / Full text
Multilayered Reprogramming in Response to Persistent DNA Damage in C. elegans. / 29.08.2017 / PubMed / Full text
Skin-resident stem cells and wound healing. / 2017 / PubMed / Full text
[Signal molecules of endometrium: gerontological and general pathhological aspects]. / 2015 / PubMed
Neuron-specific knockdown of the Drosophila fat induces reduction of life span, deficient locomotive ability, shortening of motoneuron terminal branches and defects in axonal targeting. / 07.2017 / PubMed / Full text
Decline in Proliferation and Immature Neuron Markers in the Human Subependymal Zone during Aging: Relationship to EGF- and FGF-Related Transcripts. / 2016 / PubMed / Full text
Phosphorylation of MITF by AKT affects its downstream targets and causes TP53-dependent cell senescence. / 11.2016 / PubMed / Full text
Regeneration and Carcinogenesis. / 2015 / PubMed
Loss of Maspardin Attenuates the Growth and Maturation of Mouse Cortical Neurons. / 2016 / PubMed / Full text
Whole-transcriptome analysis of mouse adipose tissue in response to short-term caloric restriction. / 04.2016 / PubMed / Full text
Biomarkers related to immunosenescence: relationships with therapy and survival in lung cancer patients. / 01.2016 / PubMed / Full text
Selective coexpression of VEGF receptor 2 in EGFRvIII-positive glioblastoma cells prevents cellular senescence and contributes to their aggressive nature. / 05.2016 / PubMed / Full text
Interleukin-6 as a first-rated serum inflammatory marker to predict mortality and hospitalization in the oldest old: A regression and CART approach in the BELFRAIL study. / 09.2015 / PubMed / Full text
Age-dependent Müller glia neurogenic competence in the mouse retina. / 10.2015 / PubMed / Full text
The Mechanism of Ligamentum Flavum Hypertrophy: Introducing Angiogenesis as a Critical Link That Couples Mechanical Stress and Hypertrophy. / 08.2015 / PubMed / Full text
Development of a chemically defined in vitro culture system to effectively stimulate the proliferation of adult human dermal fibroblasts. / 07.2015 / PubMed / Full text
Expression of vascular endothelial growth factor (VEGF) mRNA, VEGF receptor 2 (Flk-1) mRNA, and of VEGF co-receptor neuropilin (Nrp)-1 mRNA in brain tissue of aging Tg2576 mice by in situ hybridization. / 06.2015 / PubMed / Full text
Comparison of the effect of multicomponent and resistance training programs on metabolic health parameters in the elderly. / 05-06.2015 / PubMed / Full text
Effect of aging and cardiovascular risk factors on receptor Tie1 expression in human erectile tissue. / 04.2015 / PubMed / Full text
Royalactin extends lifespan of Caenorhabditis elegans through epidermal growth factor signaling. / 12.2014 / PubMed / Full text
The expression of epidermal growth factor (EGF) and its receptor (EGFR) during post-natal testes development in the yak. / 12.2014 / PubMed / Full text
The role of growth factors in maintenance of stemness in bone marrow-derived mesenchymal stem cells. / 28.02.2014 / PubMed / Full text

PCNAПравить

Impairment of Pol β-related DNA Base-excision Repair Leads to Ovarian Aging in Mice. / 20.11.2020 / PubMed / Full text
[Heat shock protein 90 (HSP90) in age-dependent changes in the number of fibroblasts in human skin.] / 2020 / PubMed
A Higher Frequency Administration of the Nontoxic Cycloartane-Type Triterpene Argentatin A Improved Its Anti-Tumor Activity. / 14.04.2020 / PubMed / Full text
[Mechanosensitive protein of Hippo regulatory pathway - transcription coactivator with PZD-binding motif (TAZ) in human skin during aging.] / 2019 / PubMed
[Mechanosensitive Yes-associated protein in human skin during aging.] / 2019 / PubMed
[Role of mechanosensitive protein Piezo1 in human age-dependent changes in the number of fibroblasts and blood vessels in human skin.] / 2019 / PubMed
Ageing in men with normal spermatogenesis alters spermatogonial dynamics and nuclear morphology in Sertoli cells. / 11.2019 / PubMed / Full text
Intestinal stem cells acquire premature senescence and senescence associated secretory phenotype concurrent with persistent DNA damage after heavy ion radiation in mice. / 25.06.2019 / PubMed / Full text
[Transforming growth factor-β (TGF-β) in human skin in the process of aging.] / 2019 / PubMed
Human Hippocampal Neurogenesis Persists in Aged Adults and Alzheimer's Disease Patients. / 06.06.2019 / PubMed / Full text
High maternal milk intake in the postnatal life reduces the incidence of breast cancer during adulthood in rats. / 08.2019 / PubMed / Full text
Prepubertal exposure to perfluorononanoic acid interferes with spermatogenesis and steroidogenesis in male mice. / 15.04.2019 / PubMed / Full text
Age Influences Microglial Activation After Cuprizone-Induced Demyelination. / 2018 / PubMed / Full text
Genome Instability Is Promoted by the Chromatin-Binding Protein Spn1 in [i]Saccharomyces cerevisiae[/i]. / 12.2018 / PubMed / Full text
MicroRNA-338-5p plays a tumor suppressor role in glioma through inhibition of the MAPK-signaling pathway by binding to FOXD1. / 12.2018 / PubMed / Full text
Conditioned medium from stimulated macrophages inhibits growth but induces an inflammatory phenotype in breast cancer cells. / 10.2018 / PubMed / Full text
[Thyroid hormone receptors in human skin during aging.] / 2018 / PubMed
Xanthohumol exerts protective effects in liver alterations associated with aging. / 03.2019 / PubMed / Full text
Comparison of naturally aging and D-galactose induced aging model in beagle dogs. / 12.2017 / PubMed / Full text
An Extract from the Plant [i]Deschampsia antarctica[/i] Protects Fibroblasts from Senescence Induced by Hydrogen Peroxide. / 2017 / PubMed / Full text
[Age-related changes in the expression of lamin B receptors in fibroblasts of human dermis]. / 2017 / PubMed
Morphological alterations in the jejunal mucosa of aged rats and the possible protective role of green tea. / 2017 / PubMed / Full text
DNA damage tolerance in hematopoietic stem and progenitor cells in mice. / 15.08.2017 / PubMed / Full text
Regulation of SIRT1/AMPK axis is critically involved in gallotannin-induced senescence and impaired autophagy leading to cell death in hepatocellular carcinoma cells. / 01.2018 / PubMed / Full text
Role of p38-MAPK pathway in the effects of high-magnitude compression on nucleus pulposus cell senescence in a disc perfusion culture. / 31.10.2017 / PubMed / Full text
Progerin-Induced Replication Stress Facilitates Premature Senescence in Hutchinson-Gilford Progeria Syndrome. / 15.07.2017 / PubMed / Full text
Age-dependent changes of the antioxidant system in rat livers are accompanied by altered MAPK activation and a decline in motor signaling. / 2015 / PubMed / Full text
Pubertal exposure to ethinylestradiol promotes different effects on the morphology of the prostate of the male and female gerbil during aging. / 02.2017 / PubMed / Full text
Argentatin B Inhibits Proliferation of Prostate and Colon Cancer Cells by Inducing Cell Senescence. / 27.11.2015 / PubMed / Full text
Microneedle fractional radiofrequency increases epidermal hyaluronan and reverses age-related epidermal dysfunction. / 02.2016 / PubMed / Full text
[POLYPEPTIDES INFLUENCE ON TISSUE CELL CULTURES REGENERATION OF VARIOUS AGE RATS]. / 2015 / PubMed
[Age-related peculiarities of the hypothalamo-hypophyseo-adrenal system in chronic heterotypic stress]. / 2015 / PubMed
Depletion of SIRT6 causes cellular senescence, DNA damage, and telomere dysfunction in human chondrocytes. / 08.2015 / PubMed / Full text
Possible intracellular regulators of female sexual maturation. / 2015 / PubMed / Full text
Profile of microRNAs associated with aging in rat liver. / 10.2014 / PubMed / Full text
Inhibition of stress induced premature senescence in presenilin-1 mutated cells with water soluble Coenzyme Q10. / 07.2014 / PubMed / Full text
Age-dependent and differential effects of Smad7ΔEx1 on neural progenitor cell proliferation and on neurogenesis. / 09.2014 / PubMed / Full text
Low-power laser irradiation fails to improve liver regeneration in elderly rats at 48 h after 70 % resection. / 09.2015 / PubMed / Full text
Age-related changes in angiogenesis in human dermis. / 07.2014 / PubMed / Full text

CD68Править

Insulin activates microglia and increases COX-2/IL-1β expression in young but not in aged hippocampus. / 15.08.2020 / PubMed / Full text
Epigenetic modulation of macrophage polarization prevents lumbar disc degeneration. / 20.04.2020 / PubMed / Full text
Cellular senescence in recurrent tonsillitis and tonsillar hypertrophy in children. / 06.2020 / PubMed / Full text
Ginsenoside Rg1 supplementation clears senescence-associated β-galactosidase in exercising human skeletal muscle. / 10.2019 / PubMed / Full text
Histopathological, immunohistochemical, and molecular studies for determination of wound age and vitality in rats. / 12.2019 / PubMed / Full text
Metabotropic glutamate receptor 5 ablation accelerates age-related neurodegeneration and neuroinflammation. / 06.2019 / PubMed / Full text
Iba-1-/CD68 microglia are a prominent feature of age-associated deep subcortical white matter lesions. / 2019 / PubMed / Full text
Forced turnover of aged microglia induces an intermediate phenotype but does not rebalance CNS environmental cues driving priming to immune challenge. / 26.11.2018 / PubMed / Full text
Partial reduction of microglia does not affect tau pathology in aged mice. / 09.11.2018 / PubMed / Full text
Effects of pepsin and pepstatin on reflux tonsil hypertrophy in vitro. / 2018 / PubMed / Full text
Age Influences Microglial Activation After Cuprizone-Induced Demyelination. / 2018 / PubMed / Full text
Pathology and Distribution of Trombiculosis in Northern Chamois ( Rupicapra rupicapra rupicapra) in the Italian Alps. / 01.2019 / PubMed / Full text
Stem Cell-Induced Pulp Regeneration Can Be Enhanced by Administration of CCL11-Neutralizing Antibody in the Ectopic Tooth Transplantation Model in the Aged Mice. / 02.2019 / PubMed / Full text
Pro- and Anti-inflammatory Effects of High Cholesterol Diet on Aged Brain. / 06.2018 / PubMed / Full text
Chia Seed Supplementation Reduces Senescence Markers in Epididymal Adipose Tissue of High-Fat Diet-Fed SAMP8 Mice. / 08.2018 / PubMed / Full text
Lifelong environmental enrichment in the absence of exercise protects the brain from age-related cognitive decline. / 02.2019 / PubMed / Full text
Age Dependent Hypothalamic and Pituitary Responses to Novel Environment Stress or Lipopolysaccharide in Rats. / 2018 / PubMed / Full text
Secreted Klotho Attenuates Inflammation-Associated Aortic Valve Fibrosis in Senescence-Accelerated Mice P1. / 05.2018 / PubMed / Full text
Salidroside attenuates endothelial cellular senescence via decreasing the expression of inflammatory cytokines and increasing the expression of SIRT3. / 10.2018 / PubMed / Full text
The age-related slow increase in amyloid pathology in APP.V717I mice activates microglia, but does not alter hippocampal neurogenesis. / 01.2018 / PubMed / Full text
Morphological alterations in the jejunal mucosa of aged rats and the possible protective role of green tea. / 2017 / PubMed / Full text
Increased White Matter Inflammation in Aging- and Alzheimer's Disease Brain. / 2017 / PubMed / Full text
Aging-related effects of bed rest followed by eccentric exercise rehabilitation on skeletal muscle macrophages and insulin sensitivity. / 01.07.2018 / PubMed / Full text
Involvement of progranulin in modulating neuroinflammatory responses but not neurogenesis in the hippocampus of aged mice. / 09.2017 / PubMed / Full text
Microglia density decreases in the rat rostral nucleus of the solitary tract across development and increases in an age-dependent manner following denervation. / 04.07.2017 / PubMed / Full text
Inhomogeneous distribution of Iba-1 characterizes microglial pathology in Alzheimer's disease. / 09.2016 / PubMed / Full text
Age-dependent increase of blood-brain barrier permeability and neuron-binding autoantibodies in S100B knockout mice. / 15.04.2016 / PubMed / Full text
Microglia in dementia with Lewy bodies. / 07.2016 / PubMed / Full text
The cricothyroid joint in elderly Japanese individuals. / 06.2016 / PubMed / Full text
Neuroimmune and Neuropathic Responses of Spinal Cord and Dorsal Root Ganglia in Middle Age. / 2015 / PubMed / Full text
A chimeric Cfh transgene leads to increased retinal oxidative stress, inflammation, and accumulation of activated subretinal microglia in mice. / 06.2015 / PubMed / Full text
Disease-related microglia heterogeneity in the hippocampus of Alzheimer's disease, dementia with Lewy bodies, and hippocampal sclerosis of aging. / 23.05.2015 / PubMed / Full text
Telomere dysfunction reduces microglial numbers without fully inducing an aging phenotype. / 06.2015 / PubMed / Full text
Temporal changes of CD68 and α7 nicotinic acetylcholine receptor expression in microglia in Alzheimer's disease-like mouse models. / 2015 / PubMed / Full text
Lipid-laden partially-activated plasmacytoid and CD4(-)CD8α( ) dendritic cells accumulate in tissues in elderly mice. / 2014 / PubMed / Full text
Combined treatment of amyloid-β₁₋₄₂-stimulated bone marrow-derived dendritic cells plus splenocytes from young mice prevents the development of Alzheimer's disease in APPswe/PSENldE9 mice. / 01.2015 / PubMed / Full text
Age-related changes in the optic nerve of Sprague-Dawley rats: an ultrastructural and immunohistochemical study. / 07.2014 / PubMed / Full text
Microglial cells in organotypic cultures of developing and adult mouse retina and their relationship with cell death. / 04.2014 / PubMed / Full text

MIPПравить

Inspiratory muscle training improves cerebrovascular and postural control responses during orthostatic stress in older women. / 10.2020 / PubMed / Full text
A novel multi-marker discovery approach identifies new serum biomarkers for Parkinson's disease in older people: an EXosomes in PArkiNson Disease (EXPAND) ancillary study. / 10.2020 / PubMed / Full text
Sexual dimorphism of physical activity on cognitive aging: Role of immune functioning. / 08.2020 / PubMed / Full text
Comparison of balance changes after inspiratory muscle or Otago exercise training. / 2020 / PubMed / Full text
[i]Lactobacillus acidophilus[/i] DDS-1 Modulates Intestinal-Specific Microbiota, Short-Chain Fatty Acid and Immunological Profiles in Aging Mice. / 07.06.2019 / PubMed / Full text
Systemic inflammation contributes to impairment of quality of life in chronic pancreatitis. / 13.05.2019 / PubMed / Full text
Open Mouth-Maximal Isometric Press: Development and Norms for Clinical Swallowing Evaluations and Treatment. / 21.02.2019 / PubMed / Full text
A New Understanding of the Role of IL-1 in Age-Related Intervertebral Disc Degeneration in a Murine Model. / 08.2019 / PubMed / Full text
Novel Chitohexaose Analog Protects Young and Aged mice from CLP Induced Polymicrobial Sepsis. / 27.02.2019 / PubMed / Full text
Inflammation and Monocyte Recruitment due to Aging and Mechanical Stretch in Alveolar Epithelium are Inhibited by the Molecular Chaperone 4-phenylbutyrate. / 12.2018 / PubMed / Full text
Prophylactic Palmitoylethanolamide Prolongs Survival and Decreases Detrimental Inflammation in Aged Mice With Bacterial Meningitis. / 2018 / PubMed / Full text
Establishment of a lethal aged mouse model of human respiratory syncytial virus infection. / 01.2019 / PubMed / Full text
Mitochondrial DNA variants and pulmonary function in older persons. / 01.2019 / PubMed / Full text
Respiratory Muscle Strength as a Discriminator of Sarcopenia in Community-Dwelling Elderly: A Cross-Sectional Study. / 2018 / PubMed / Full text
The Role of Pulmonary and Systemic Immunosenescence in Acute Lung Injury. / 08.2018 / PubMed / Full text
Cortical and hippocampal expression of inflammatory and intracellular signaling proteins in aged rats submitted to aerobic and resistance physical training. / 09.2018 / PubMed / Full text
Age-Related Changes to Human Tear Composition. / 01.04.2018 / PubMed / Full text
Sex Differences in Adipose Tissue CD8 T Cells and Regulatory T Cells in Middle-Aged Mice. / 2018 / PubMed / Full text
Reaction time in healthy elderly is associated with chronic low-grade inflammation and advanced glycation end product. / 15.07.2018 / PubMed / Full text
Inspiratory muscle training improves physical performance and cardiac autonomic modulation in older women. / 06.2018 / PubMed / Full text
Cerebrospinal Fluid and Plasma Levels of Inflammation Differentially Relate to CNS Markers of Alzheimer's Disease Pathology and Neuronal Damage. / 2018 / PubMed / Full text
Skeletal Muscle Injury Biomarkers: Assay Qualification Efforts and Translation to the Clinic. / 10.2017 / PubMed / Full text
Brainstem cytokine changes in healthy ageing and Motor Neurone Disease. / 15.10.2017 / PubMed / Full text
Validity of maximum isometric tongue pressure as a screening test for physical frailty: Cross-sectional study of Japanese community-dwelling older adults. / 02.2018 / PubMed / Full text
Middle age exacerbates acute respiratory distress syndrome in a double hit murine model. / 01.10.2017 / PubMed / Full text
Evaluation of Respiratory Muscle Strength in the Acute Phase of Stroke: The Role of Aging and Anthropometric Variables. / 10.2017 / PubMed / Full text
Epstein-Barr virus latent membrane protein-1 up-regulates cytokines and correlates with older age and poorer prognosis in Hodgkin lymphoma. / 02.2017 / PubMed / Full text
The effect of sex on immune cells in healthy aging: Elderly women have more robust natural killer lymphocytes than do elderly men. / 06.2016 / PubMed / Full text
Skewing of peritoneal resident macrophages toward M1-like is involved in enhancement of inflammatory responses induced by secondary necrotic neutrophils in aged mice. / 06-07.2016 / PubMed / Full text
Acute effects of different inspiratory efforts on ventilatory pattern and chest wall compartmental distribution in elderly women. / 15.06.2016 / PubMed / Full text
Cholecystokinin expression in the β-cell leads to increased β-cell area in aged mice and protects from streptozotocin-induced diabetes and apoptosis. / 15.11.2015 / PubMed / Full text
Association of systemic inflammation with epicardial fat and coronary artery calcification. / 05.2015 / PubMed / Full text
Ovariectomy shortens the life span of female mice. / 10.05.2015 / PubMed / Full text
Postural vital capacity difference with aging in duchenne muscular dystrophy. / 11.2015 / PubMed / Full text
Attenuated phagocytosis of secondary necrotic neutrophils by macrophages in aged and SMP30 knockout mice. / 01.2016 / PubMed / Full text
Distinct age-matched serum biomarker profiles in patients with cutaneous T-cell lymphoma. / 08.2014 / PubMed / Full text
Relationship between respiratory muscle strength and physical performance in elderly hospitalized patients. / 08.2014 / PubMed / Full text
Neutrophil depletion in the early inflammatory phase delayed cutaneous wound healing in older rats: improvements due to the use of un-denatured camel whey protein. / 04.03.2014 / PubMed / Full text

CORTПравить

Sex differences in body composition, metabolism-related hormones, and energy homeostasis during aging in Wistar rats. / 10.2020 / PubMed / Full text
Effects of age and social isolation on murine hippocampal biochemistry and behavior. / 10.2020 / PubMed / Full text
Interleukin 6 reduces allopregnanolone synthesis in the brain and contributes to age-related cognitive decline in mice. / 10.2020 / PubMed / Full text
Sex- and age-dependent differences in the hormone and drinking responses to water deprivation. / 01.03.2020 / PubMed / Full text
Ontogeny of the adrenocortical response in an extremely altricial bird. / 12.2019 / PubMed / Full text
Exposure to jet lag aggravates depression-like behaviors and age-related phenotypes in rats subject to chronic corticosterone. / 05.08.2019 / PubMed / Full text
Hyperadrenocorticism of calorie restriction contributes to its anti-inflammatory action in mice. / 06.2019 / PubMed / Full text
Effect of chronic corticosterone-induced depression on circadian rhythms and age-related phenotypes in mice. / 01.12.2018 / PubMed / Full text
Early Life Stress Strengthens Trait Covariance: A Plastic Response That Results in Reduced Flexibility. / 11.2018 / PubMed / Full text
Both Basal and Acute Restraint Stress-Induced c-Fos Expression Is Influenced by Age in the Extended Amygdala and Brainstem Stress Centers in Male Rats. / 2018 / PubMed / Full text
Stress-induced corticosterone secretion covaries with working memory in aging. / 11.2018 / PubMed / Full text
Sex-specific differences in corticosterone secretion, behavioral phenotypes and expression of TrkB.T1 and TrkB.FL receptor isoforms: Impact of systemic TrkB inhibition and combinatory stress exposure in adolescence. / 30.08.2018 / PubMed / Full text
Lifelong Aerobic Exercise Reduces the Stress Response in Rats. / 15.04.2018 / PubMed / Full text
sst -receptor gene deletion exacerbates chronic stress-induced deficits: Consequences for emotional and cognitive ageing. / 30.08.2018 / PubMed / Full text
Chronic corticosterone-induced depression mediates premature aging in rats. / 15.03.2018 / PubMed / Full text
Effects of developmental conditions on glucocorticoid concentrations in adulthood depend on sex and foraging conditions. / 07.2017 / PubMed / Full text
Corticosterone Response as an Age-Specific Mediator of Nestling Body Mass in a Wild Passerine. / 07-08.2017 / PubMed / Full text
Impact of transportation duration on stress responses in day-old chicks from young and old breeders. / 06.2017 / PubMed / Full text
Long-term effects of adolescent stress on neophobic behaviors in zebra finches are modulated by social context when in adulthood. / 04.2017 / PubMed / Full text
A chronic increase of corticosterone age-dependently reduces systemic DNA damage from oxidation in rats. / 03.2017 / PubMed / Full text
Prenatal betaine exposure alleviates corticosterone-induced inhibition of CYP27A1 expression in the liver of juvenile chickens associated with its promoter DNA methylation. / 15.05.2017 / PubMed / Full text
Ancestry trumps experience: Transgenerational but not early life stress affects the adult physiological stress response. / 01.2017 / PubMed / Full text
Chronic corticosterone treatment enhances extinction-induced depression in aged rats. / 11.2016 / PubMed / Full text
Effects of Ontogeny, Diel Rhythms, and Environmental Variation on the Adrenocortical Physiology of Semialtricial Black Kites (Milvus migrans). / 05-06.2016 / PubMed / Full text
Chronic intermittent ethanol exposure during adolescence: Effects on stress-induced social alterations and social drinking in adulthood. / 01.01.2017 / PubMed / Full text
Adolescent caffeine consumption increases adulthood anxiety-related behavior and modifies neuroendocrine signaling. / 05.2016 / PubMed / Full text
Short photoperiod condition increases susceptibility to stress in adolescent male rats. / 01.03.2016 / PubMed / Full text
Age and sex differences in c-Fos expression and serum corticosterone concentration following LPS treatment. / 01.10.2015 / PubMed / Full text
Diurnal and stress-induced intra-hippocampal corticosterone rise attenuated in 11β-HSD1-deficient mice: a microdialysis study in young and aged mice. / 03.2015 / PubMed / Full text
A comparison of the short- and long-term effects of corticosterone exposure on extinction in adolescence versus adulthood. / 12.2014 / PubMed / Full text
Variation in plasma corticosterone in migratory songbirds: a test of the migration-modulation hypothesis. / 09-10.2014 / PubMed / Full text
Calorie restriction and corticosterone elevation during lactation can each modulate adult male fear and anxiety-like behaviour. / 09.2014 / PubMed / Full text
Age-dependent effect of high cholesterol diets on anxiety-like behavior in elevated plus maze test in rats. / 01.09.2014 / PubMed / Full text
Intrahippocampal glucocorticoids generated by 11β-HSD1 affect memory in aged mice. / 01.2015 / PubMed / Full text
Age-dependent sensitivity to glucocorticoids in the developing mouse basolateral nucleus of the amygdala. / 08.2014 / PubMed / Full text
Maternal effects underlie ageing costs of growth in the zebra finch (Taeniopygia guttata). / 2014 / PubMed / Full text
Serotonin and corticosterone rhythms in mice exposed to cigarette smoke and in patients with COPD: implication for COPD-associated neuropathogenesis. / 2014 / PubMed / Full text

FGF21Править

Differential effects of sulfur amino acid-restricted and low-calorie diets on gut microbiome profile and bile acid composition in male C57BL6/J mice. / 27.10.2020 / PubMed / Full text
Relationship between physical activity and circulating fibroblast growth factor 21 in middle-aged and older adults. / 11.2020 / PubMed / Full text
Exercise and dietary intervention ameliorate high-fat diet-induced NAFLD and liver aging by inducing lipophagy. / 09.2020 / PubMed / Full text
Mitochondria, immunosenescence and inflammaging: a role for mitokines? / 10.2020 / PubMed / Full text
Age-at-onset-dependent effects of sulfur amino acid restriction on markers of growth and stress in male F344 rats. / 07.2020 / PubMed / Full text
Fibroblast growth factor 21 prolongs lifespan and improves stress tolerance in the silkworm, [i]Bombyx mori[/i]. / 03.2020 / PubMed / Full text
Neurogenesis and prolongevity signaling in young germ-free mice transplanted with the gut microbiota of old mice. / 13.11.2019 / PubMed / Full text
Fibroblast Growth Factor 21 Mediates the Associations between Exercise, Aging, and Glucose Regulation. / 02.2020 / PubMed / Full text
Effects of Moderate Chronic Food Restriction on the Development of Postprandial Dyslipidemia with Ageing. / 10.08.2019 / PubMed / Full text
Inhibition of the Fission Machinery Mitigates OPA1 Impairment in Adult Skeletal Muscles. / 15.06.2019 / PubMed / Full text
Higher serum levels of fibroblast growth factor 21 in old patients with cachexia. / 07-08.2019 / PubMed / Full text
Impact of aging and caloric restriction on fibroblast growth factor 21 signaling in rat white adipose tissue. / 04.2019 / PubMed / Full text
Kotho and aging. / 09.2016 / PubMed
The Klotho proteins in health and disease. / 01.2019 / PubMed / Full text
Towards frailty biomarkers: Candidates from genes and pathways regulated in aging and age-related diseases. / 11.2018 / PubMed / Full text
Aging is associated with increased FGF21 levels but unaltered FGF21 responsiveness in adipose tissue. / 10.2018 / PubMed / Full text
Genome-wide meta-analysis of macronutrient intake of 91,114 European ancestry participants from the cohorts for heart and aging research in genomic epidemiology consortium. / 12.2019 / PubMed / Full text
Human Aging and Longevity Are Characterized by High Levels of Mitokines. / 23.04.2019 / PubMed / Full text
[Fibroblast growth factor-21 as a marker of premature aging in young and middled-aged men with type 2 diabetes]. / 03.2018 / PubMed
Fibroblast growth factor 21 delayed endothelial replicative senescence and protected cells from H O -induced premature senescence through SIRT1. / 2017 / PubMed / Full text
Integrated stress response stimulates FGF21 expression: Systemic enhancer of longevity. / 12.2017 / PubMed / Full text
Fibroblast growth factor 21: a regulator of metabolic disease and health span. / 01.09.2017 / PubMed / Full text
Age-Associated Loss of OPA1 in Muscle Impacts Muscle Mass, Metabolic Homeostasis, Systemic Inflammation, and Epithelial Senescence. / 06.06.2017 / PubMed / Full text
Regulation of longevity by FGF21: Interaction between energy metabolism and stress responses. / 08.2017 / PubMed / Full text
FGF21 activates AMPK signaling: impact on metabolic regulation and the aging process. / 02.2017 / PubMed / Full text
Methionine restriction improves renal insulin signalling in aged kidneys. / 07.2016 / PubMed / Full text
FGF21 represses cerebrovascular aging via improving mitochondrial biogenesis and inhibiting p53 signaling pathway in an AMPK-dependent manner. / 15.08.2016 / PubMed / Full text
Role of mitochondrial function in cell death and body metabolism. / 01.06.2016 / PubMed / Full text
Prolongevity hormone FGF21 protects against immune senescence by delaying age-related thymic involution. / 26.01.2016 / PubMed / Full text
Differentiated embryo chondrocyte 1 (DEC1) is a novel negative regulator of hepatic fibroblast growth factor 21 (FGF21) in aging mice. / 15.01.2016 / PubMed / Full text
Effect of mitochondrial stress on systemic metabolism. / 09.2015 / PubMed / Full text
Muscle-specific 4E-BP1 signaling activation improves metabolic parameters during aging and obesity. / 03.08.2015 / PubMed / Full text
Circulating levels of fibroblast growth factor-21 increase with age independently of body composition indices among healthy individuals. / 01.06.2015 / PubMed / Full text
A preliminary candidate approach identifies the combination of chemerin, fetuin-A, and fibroblast growth factors 19 and 21 as a potential biomarker panel of successful aging. / 06.2015 / PubMed / Full text
Fibroblast growth factor 21 protects mouse brain against D-galactose induced aging via suppression of oxidative stress response and advanced glycation end products formation. / 06.2015 / PubMed / Full text
Cardiorespiratory fitness and visceral fat are key determinants of serum fibroblast growth factor 21 concentration in Japanese men. / 10.2014 / PubMed / Full text
Methionine restriction restores a younger metabolic phenotype in adult mice with alterations in fibroblast growth factor 21. / 10.2014 / PubMed / Full text

ABRПравить

[Hidden hearing loss and early identification]. / 07.2020 / PubMed / Full text
Aging But Not Age-Related Hearing Loss Dominates the Decrease of Parvalbumin Immunoreactivity in the Primary Auditory Cortex of Mice. / 05-06.2020 / PubMed / Full text
Hearing loss through apoptosis of the spiral ganglion neurons in apolipoprotein E knockout mice fed with a western diet. / 12.03.2020 / PubMed / Full text
Effects of enriched endogenous omega-3 fatty acids on age-related hearing loss in mice. / 26.11.2019 / PubMed / Full text
Hearing impairment and associated morphological changes in pituitary adenylate cyclase activating polypeptide (PACAP)-deficient mice. / 10.10.2019 / PubMed / Full text
Global nurse/midwife workforce and reproductive health through social ecology lens. / 09.2019 / PubMed / Full text
Urocortin 3 signalling in the auditory brainstem aids recovery of hearing after reversible noise-induced threshold shift. / 08.2019 / PubMed / Full text
Age‑associated variation in the expression and function of TMEM16A calcium‑activated chloride channels in the cochlear stria vascularis of guinea pigs. / 08.2019 / PubMed / Full text
Hormone replacement therapy attenuates hearing loss: Mechanisms involving estrogen and the IGF-1 pathway. / 06.2019 / PubMed / Full text
Evidence for age-related cochlear synaptopathy in humans unconnected to speech-in-noise intelligibility deficits. / 15.03.2019 / PubMed / Full text
Masking Differentially Affects Envelope-following Responses in Young and Aged Animals. / 21.08.2018 / PubMed / Full text
Effects of Age on Speech-in-Noise Identification: Subjective Ratings of Hearing Difficulties and Encoding of Fundamental Frequency in Older Adults. / 06.2018 / PubMed / Full text
Age-Related Differences in Hearing Function and Cochlear Morphology between Male and Female Fischer 344 Rats. / 2017 / PubMed / Full text
The FBN rat model of aging: investigation of ABR waveforms and ribbon synapse changes. / 02.2018 / PubMed / Full text
Senescence-accelerated mouse prone 8 (SAMP8) as a model of age-related hearing loss. / 24.08.2017 / PubMed / Full text
Otoprotective effects of ethosuximide in NOD/LtJ mice with age-related hearing loss. / 07.2017 / PubMed / Full text
Involvement of p53 and Bcl-2 in sensory cell degeneration in aging rat cochleae. / 06.2017 / PubMed / Full text
Age-associated expression of erythropoietin and its receptor in rat spiral ganglion neurons and its association with neuronal apoptosis and hearing alterations. / 01.2017 / PubMed / Full text
Reading ability reflects individual differences in auditory brainstem function, even into adulthood. / 01.2017 / PubMed / Full text
The effects of aging and sex on detection of ultrasonic vocalizations by adult CBA/CaJ mice (Mus musculus). / 11.2016 / PubMed / Full text
Effects of aging on peripheral and central auditory processing in rats. / 08.2016 / PubMed / Full text
Aging effects on the binaural interaction component of the auditory brainstem response in the Mongolian gerbil: Effects of interaural time and level differences. / 07.2016 / PubMed / Full text
The LEA protein, ABR, is regulated by ABI5 and involved in dark-induced leaf senescence in Arabidopsis thaliana. / 06.2016 / PubMed / Full text
Dietary intake of heat-killed Lactococcus lactis H61 delays age-related hearing loss in C57BL/6J mice. / 22.03.2016 / PubMed / Full text
Age-Related Changes in Binaural Interaction at Brainstem Level. / 07-08.2016 / PubMed / Full text
[Expression of Dynamin in the cochlea of mice of different ages]. / 07.2015 / PubMed
Hyperinsulinemia/diabetes, hearing, and aging in the University of Wisconsin calorie restriction monkeys. / 10.2015 / PubMed / Full text
Age-related changes of auditory brainstem responses in nonhuman primates. / 07.2015 / PubMed / Full text
Aging after noise exposure: acceleration of cochlear synaptopathy in "recovered" ears. / 13.05.2015 / PubMed / Full text
Prophylaxis in older Canadian adults with hemophilia A: lessons and more questions. / 2015 / PubMed / Full text
Age-related changes in auditory nerve-inner hair cell connections, hair cell numbers, auditory brain stem response and gap detection in UM-HET4 mice. / 30.04.2015 / PubMed / Full text
Accuracy of auditory steady state and auditory brainstem responses to detect the preventive effect of polyphenols on age-related hearing loss in Sprague-Dawley rats. / 02.2016 / PubMed / Full text
Auditory brainstem gap responses start to decline in mice in middle age: a novel physiological biomarker for age-related hearing loss. / 07.2015 / PubMed / Full text
Age-related neurochemical changes in the rhesus macaque superior olivary complex. / 20.12.2013 / PubMed / Full text
Age-related changes in the relationship between auditory brainstem responses and envelope-following responses. / 08.2014 / PubMed / Full text
Age-related neurochemical changes in the rhesus macaque inferior colliculus. / 2014 / PubMed / Full text

CCKПравить

Senolytic agent Quercetin ameliorates intervertebral disc degeneration via the Nrf2/NF-κB axis. / 23.11.2020 / PubMed / Full text
Astragalus improve aging bone marrow mesenchymal stem cells (BMSCs) vitality and osteogenesis through VD-FGF23-Klotho axis. / 2020 / PubMed / Full text
Effects of Age on Acute Appetite-Related Responses to Whey-Protein Drinks, Including Energy Intake, Gastric Emptying, Blood Glucose, and Plasma Gut Hormone Concentrations-A Randomized Controlled Trial. / 06.04.2020 / PubMed / Full text
Lactose induced redox-dependent senescence and activated Nrf2 pathway. / 2019 / PubMed / Full text
Quercetin Suppresses the Progression of Atherosclerosis by Regulating MST1-Mediated Autophagy in ox-LDL-Induced RAW264.7 Macrophage Foam Cells. / 03.12.2019 / PubMed / Full text
LncRNA AW112010 Promotes Mitochondrial Biogenesis and Hair Cell Survival: Implications for Age-Related Hearing Loss. / 2019 / PubMed / Full text
Effects of age on feeding response: Focus on the rostral C1 neuron and its glucoregulatory proteins. / 01.2020 / PubMed / Full text
Ser-Tyr and Asn-Ala, vasorelaxing dipeptides found by comprehensive screening, reduce blood pressure via different age-dependent mechanisms. / 04.11.2019 / PubMed / Full text
Fisetin, via CKIP-1/REGγ, limits oxidized LDL-induced lipid accumulation and senescence in RAW264.7 macrophage-derived foam cells. / 15.12.2019 / PubMed / Full text
[Ginsenoside Rg_1 induces leukemia stem cell senescence via SIRT1/TSC_2 signal axis]. / 06.2019 / PubMed / Full text
Chromatin remodeling factor BAZ1A regulates cellular senescence in both cancer and normal cells. / 15.07.2019 / PubMed / Full text
Circular RNA expression profile in human fibroblast premature senescence after repeated ultraviolet B irradiations revealed by microarray. / 08.2019 / PubMed / Full text
Long non-coding RNA-OIS1 inhibits HPV-positive, but not HPV-negative cervical squamous cell carcinoma by upregulating MTK-1. / 03.2019 / PubMed / Full text
Ubiquinol-cytochrome C reductase core protein II promotes tumorigenesis by facilitating p53 degradation. / 02.2019 / PubMed / Full text
MiR-34a Enhances Chondrocyte Apoptosis, Senescence and Facilitates Development of Osteoarthritis by Targeting DLL1 and Regulating PI3K/AKT Pathway. / 2018 / PubMed / Full text
Inhibition of glioma growth by flavokawain B is mediated through endoplasmic reticulum stress induced autophagy. / 2018 / PubMed / Full text
Apelin/APJ axis improves angiotensin II-induced endothelial cell senescence through AMPK/SIRT1 signaling pathway. / 06.2018 / PubMed / Full text
Osthole Delays Tert-Butyl Hydroperoxide-Induced Premature Senescence in Neural Stem Cells. / 08.2018 / PubMed / Full text
N-Cadherin Attenuates High Glucose-Induced Nucleus Pulposus Cell Senescence Through Regulation of the ROS/NF-κB Pathway. / 2018 / PubMed / Full text
Localization of cholecystokinin in the zebrafish retina from larval to adult stage. / 07.2018 / PubMed / Full text
Glutamate-dependent regulation of food intake is altered with age through changes in NMDA receptor phenotypes on vagal afferent neurons. / 15.05.2018 / PubMed / Full text
Effects of Substitution, and Adding of Carbohydrate and Fat to Whey-Protein on Energy Intake, Appetite, Gastric Emptying, Glucose, Insulin, Ghrelin, CCK and GLP-1 in Healthy Older Men-A Randomized Controlled Trial. / 23.01.2018 / PubMed / Full text
Effect of Age on Blood Glucose and Plasma Insulin, Glucagon, Ghrelin, CCK, GIP, and GLP-1 Responses to Whey Protein Ingestion. / 21.12.2017 / PubMed / Full text
Triptolide Promotes Senescence of Prostate Cancer Cells Through Histone Methylation and Heterochromatin Formation / 27.09.2017 / PubMed / Full text
[Effects of ginseng, notoginseng, and Chuanxiong Rhizoma extracts on cytoskeleton protein of replicative senescence vascular smooth muscle cells]. / 02.2016 / PubMed / Full text
[Inula Britannica flower total flavonoids reduces the apoptosis of aging bone marrow mesenchymal stem cells by anti-oxidation]. / 05.2017 / PubMed
[The mechanism of bone marrow-derived mesenchymal stem cells excessive senescence in severe aplastic anemia mouse model]. / 14.04.2017 / PubMed / Full text
Overexpression of miR-584-5p inhibits proliferation and induces apoptosis by targeting WW domain-containing E3 ubiquitin protein ligase 1 in gastric cancer. / 21.04.2017 / PubMed / Full text
Molecular mechanism of G arrest and cellular senescence induced by LEE011, a novel CDK4/CDK6 inhibitor, in leukemia cells. / 2017 / PubMed / Full text
Exogenous H2S contributes to recovery of ischemic post-conditioning-induced cardioprotection by decrease of ROS level via down-regulation of NF-κB and JAK2-STAT3 pathways in the aging cardiomyocytes. / 2016 / PubMed / Full text
Resveratrol attenuates senescence of adipose-derived mesenchymal stem cells and restores their paracrine effects on promoting insulin secretion of INS-1 cells through Pim-1. / 2016 / PubMed
Cholecystokinin expression in the β-cell leads to increased β-cell area in aged mice and protects from streptozotocin-induced diabetes and apoptosis. / 15.11.2015 / PubMed / Full text
Down-Regulated NRSN2 Promotes Cell Proliferation and Survival Through PI3K/Akt/mTOR Pathway in Hepatocellular Carcinoma. / 10.2015 / PubMed / Full text
The positive effects of Ginsenoside Rg1 upon the hematopoietic microenvironment in a D-Galactose-induced aged rat model. / 15.04.2015 / PubMed / Full text
Exposure to a high fat diet during the perinatal period alters vagal motoneurone excitability, even in the absence of obesity. / 01.01.2015 / PubMed / Full text
Ionizing irradiation inhibits keloid fibroblast cell proliferation and induces premature cellular senescence. / 01.2015 / PubMed / Full text

CD14Править

Human innate immune cell crosstalk induces melanoma cell senescence. / 30.08.2020 / PubMed / Full text
Fusion Potential of Human Osteoclasts In Vitro Reflects Age, Menopause, and In Vivo Bone Resorption Levels of Their Donors-A Possible Involvement of DC-STAMP. / 02.09.2020 / PubMed / Full text
Association of CD14 with incident dementia and markers of brain aging and injury. / 21.01.2020 / PubMed / Full text
Compromised Bone Healing in Aged Rats Is Associated With Impaired M2 Macrophage Function. / 2019 / PubMed / Full text
Adipose-Derived Stem/Stromal Cells Recapitulate Aging Biomarkers and Show Reduced Stem Cell Plasticity Affecting Their Adipogenic Differentiation Capacity. / 08.2019 / PubMed / Full text
Increased monocyte activation with age among HIV-infected long term non-progressor children: implications for early treatment initiation. / 09.2019 / PubMed / Full text
Wheat seed ageing viewed through the cellular redox environment and changes in pH. / 06.2019 / PubMed / Full text
Senescent Phenotype Induced by p90RSK-NRF2 Signaling Sensitizes Monocytes and Macrophages to Oxidative Stress in HIV-Positive Individuals. / 26.02.2019 / PubMed / Full text
Effects of pepsin and pepstatin on reflux tonsil hypertrophy in vitro. / 2018 / PubMed / Full text
Innate and adaptive immune dysregulation in critically ill ICU patients. / 05.07.2018 / PubMed / Full text
Serum Zonulin and Endotoxin Levels in Exceptional Longevity versus Precocious Myocardial Infarction. / 04.2018 / PubMed / Full text
Rapid Turnover and High Production Rate of Myeloid Cells in Adult Rhesus Macaques with Compensations during Aging. / 15.06.2018 / PubMed / Full text
Human colostrum action against Giardia lamblia infection influenced by hormones and advanced maternal age. / 06.2018 / PubMed / Full text
The pro-inflammatory phenotype of the human non-classical monocyte subset is attributed to senescence. / 15.02.2018 / PubMed / Full text
Aged Chinese-origin rhesus macaques infected with SIV develop marked viremia in absence of clinical disease, inflammation or cognitive impairment. / 01.02.2018 / PubMed / Full text
Stem Cells and Progenitors in Human Peripheral Blood Get Activated by Extremely Active Resveratrol (XAR™). / 04.2018 / PubMed / Full text
Acute Effects of Nitrate-Rich Beetroot Juice on Blood Pressure, Hemostasis and Vascular Inflammation Markers in Healthy Older Adults: A Randomized, Placebo-Controlled Crossover Study. / 22.11.2017 / PubMed / Full text
Proteomic profiling of follicle fluids after superstimulation in one-month-old lambs. / 02.2018 / PubMed / Full text
Latent Cytomegalovirus (CMV) Infection Does Not Detrimentally Alter T Cell Responses in the Healthy Old, But Increased Latent CMV Carriage Is Related to Expanded CMV-Specific T Cells. / 2017 / PubMed / Full text
HIV and Obesity Comorbidity Increase Interleukin 6 but Not Soluble CD14 or D-Dimer. / 15.08.2017 / PubMed / Full text
Immunosenescence Induced by Plasma from Individuals with Obesity Caused Cell Signaling Dysfunction and Inflammation. / 09.2017 / PubMed / Full text
β -Microglobulin participates in development of lung emphysema by inducing lung epithelial cell senescence. / 01.05.2017 / PubMed / Full text
Age-dependent cellular reactions of the human immune system of humanized NOD scid gamma mice on LPS stimulus. / 04.2017 / PubMed / Full text
Immune Activation and Bacterial Translocation: A Link between Impaired Immune Recovery and Frequent Visceral Leishmaniasis Relapses in HIV-Infected Patients. / 2016 / PubMed / Full text
Impaired phagocytosis of apoptotic cells causes accumulation of bone marrow-derived macrophages in aged mice. / 01.2017 / PubMed / Full text
Do Biomarkers of Inflammation, Monocyte Activation, and Altered Coagulation Explain Excess Mortality Between HIV Infected and Uninfected People? / 01.06.2016 / PubMed / Full text
Strain-dependent response to stimulation in middle-aged rat macrophages: A quest after a useful indicator of healthy aging. / 01.12.2016 / PubMed / Full text
Distinct inflammatory phenotypes of microglia and monocyte-derived macrophages in Alzheimer's disease models: effects of aging and amyloid pathology. / 02.2017 / PubMed / Full text
Red Wine Prevents the Acute Negative Vascular Effects of Smoking. / 01.2017 / PubMed / Full text
T-Cell Activation Independently Associates With Immune Senescence in HIV-Infected Recipients of Long-term Antiretroviral Treatment. / 15.07.2016 / PubMed / Full text
Cytomegalovirus viral load within blood increases markedly in healthy people over the age of 70 years. / 2016 / PubMed / Full text
Elevated Levels of Microbial Translocation Markers and CCL2 Among Older HIV-1-Infected Men. / 01.03.2016 / PubMed / Full text
Persistent Immune Activation and Carotid Atherosclerosis in HIV-Infected Ugandans Receiving Antiretroviral Therapy. / 01.02.2016 / PubMed / Full text
Macrophage subsets in the adipose tissue could be modified by sex and the reproductive age of women. / 07.2015 / PubMed / Full text
Visceral leishmaniasis as an independent cause of high immune activation, T-cell senescence, and lack of immune recovery in virologically suppressed HIV-1-coinfected patients. / 04.2015 / PubMed / Full text
Aging oppositely affects TNF-α and IL-10 production by macrophages from different rat strains. / 2014 / PubMed / Full text

CD44Править

Hyaluronan goes to great length. / 17.07.2020 / PubMed / Full text
Naked mole-rat very-high-molecular-mass hyaluronan exhibits superior cytoprotective properties. / 12.05.2020 / PubMed / Full text
Maturity-dependent cartilage cell plasticity and sensitivity to external perturbation. / 06.2020 / PubMed / Full text
Aged Mice Exhibit Severe Exacerbations of Dry Eye Disease with an Amplified Memory Th17 Cell Response. / 07.2020 / PubMed / Full text
Chronic circadian misalignment accelerates immune senescence and abbreviates lifespan in mice. / 13.02.2020 / PubMed / Full text
Defective induction of the proteasome associated with T-cell receptor signaling underlies T-cell senescence. / 12.2019 / PubMed / Full text
CD44v8-10 and CD44s Are Age-dependently Expressed in Primary Cultured Papillary Thyroid Carcinoma Cells and Are Associated with Cell Proliferation. / 25.04.2019 / PubMed / Full text
Immunophenotypic characterization, multi-lineage differentiation and aging of zebrafish heart and liver tissue-derived mesenchymal stem cells as a novel approach in stem cell-based therapy. / 04.2019 / PubMed / Full text
CD8 , but not CD4 effector/memory T cells, express the [[CD44]] CD45RB phenotype with aging, which displays reduced expression levels of P2X receptor and ATP-induced cellular responses. / 03.2019 / PubMed / Full text
Regenerative potential of human nucleus pulposus resident stem/progenitor cells declines with ageing and intervertebral disc degeneration. / 10.2018 / PubMed / Full text
Multi-color flow cytometry for evaluating age-related changes in memory lymphocyte subsets in dogs. / 10.2018 / PubMed / Full text
Therapeutic efficacy of olfactory stem cells in rotenone induced Parkinsonism in adult male albino rats. / 07.2018 / PubMed / Full text
Precise Intradermal Injection of Nanofat-Derived Stromal Cells Combined with Platelet-Rich Fibrin Improves the Efficacy of Facial Skin Rejuvenation. / 2018 / PubMed / Full text
Some chemotherapeutics-treated colon cancer cells display a specific phenotype being a combination of stem-like and senescent cell features. / 02.01.2018 / PubMed / Full text
A Trickster in Disguise: Hyaluronan's Ambivalent Roles in the Matrix. / 2017 / PubMed / Full text
Longevity effect of a polysaccharide from Chlorophytum borivilianum on Caenorhabditis elegans and Saccharomyces cerevisiae. / 2017 / PubMed / Full text
Physiologic Thymic Involution Underlies Age-Dependent Accumulation of Senescence-Associated CD4 T Cells. / 01.07.2017 / PubMed / Full text
CD44 alveolar type II cells show stem cell properties during steady-state alveolar homeostasis. / 01.07.2017 / PubMed / Full text
Senescence-associated IL-6 and IL-8 cytokines induce a self- and cross-reinforced senescence/inflammatory milieu strengthening tumorigenic capabilities in the MCF-7 breast cancer cell line. / 04.05.2017 / PubMed / Full text
Sialylation regulates myofibroblast differentiation of human skin fibroblasts. / 18.04.2017 / PubMed / Full text
Calorie Restriction Attenuates Terminal Differentiation of Immune Cells. / 2016 / PubMed / Full text
Identification and characterization of adult mouse meniscus stem/progenitor cells. / 05-07.2017 / PubMed / Full text
Development and mechanistic insight into enhanced cytotoxic potential of hyaluronic acid conjugated nanoparticles in CD44 overexpressing cancer cells. / 15.01.2017 / PubMed / Full text
Review: Astrocytes in Alzheimer's disease and other age-associated dementias: a supporting player with a central role. / 06.2017 / PubMed / Full text
Disentangling the aneuploidy and senescence paradoxes: a study of triploid breast cancers non-responsive to neoadjuvant therapy. / 04.2016 / PubMed / Full text
Heightened self-reactivity associated with selective survival, but not expansion, of naïve virus-specific CD8 T cells in aged mice. / 02.02.2016 / PubMed / Full text
Characterization of age-associated exhausted CD8⁺ T cells defined by increased expression of Tim-3 and PD-1. / 04.2016 / PubMed / Full text
miR-34a inhibits differentiation of human adipose tissue-derived stem cells by regulating cell cycle and senescence induction. / 11-12.2015 / PubMed / Full text
Microneedle fractional radiofrequency increases epidermal hyaluronan and reverses age-related epidermal dysfunction. / 02.2016 / PubMed / Full text
Age-independent effects of hyaluronan amide derivative and growth hormone on human osteoarthritic chondrocytes. / 11.2015 / PubMed / Full text
Changes in glomerular parietal epithelial cells in mouse kidneys with advanced age. / 15.07.2015 / PubMed / Full text
In vitro 3-D model based on extending time of culture for studying chronological epidermis aging. / 09.2015 / PubMed / Full text
Premature aging induced by radiation exhibits pro-atherosclerotic effects mediated by epigenetic activation of CD44 expression. / 10.2014 / PubMed / Full text
Hyaluronan enhances wound repair and increases collagen III in aged dermal wounds. / 07-08.2014 / PubMed / Full text
Metzincins and related genes in experimental renal ageing: towards a unifying fibrosis classifier across species. / 06.2014 / PubMed / Full text
Immunohistochemical patterns in the interfollicular Caucasian scalps: influences of age, gender, and alopecia. / 2013 / PubMed / Full text

MYCПравить

Enhanced proliferative capacity of human preadipocytes achieved by an optimized cultivating method that induces transient activity of hTERT. / 20.08.2020 / PubMed / Full text
Collaboration of MYC and RUNX2 in lymphoma simulates T-cell receptor signaling and attenuates p53 pathway activity. / 10.2019 / PubMed / Full text
Regulation of RhoB Gene Expression during Tumorigenesis and Aging Process and Its Potential Applications in These Processes. / 13.06.2019 / PubMed / Full text
Transcriptomic analysis of human IL-7 receptor alpha and effector memory CD8 T cells reveals an age-associated signature linked to influenza vaccine response in older adults. / 08.2019 / PubMed / Full text
SLC1A5 glutamine transporter is a target of MYC and mediates reduced mTORC1 signaling and increased fatty acid oxidation in long-lived Myc hypomorphic mice. / 06.2019 / PubMed / Full text
Profound, durable and MGMT-independent sensitivity of glioblastoma cells to cyclin-dependent kinase inhibition. / 01.07.2019 / PubMed / Full text
MYC and RAS are unable to cooperate in overcoming cellular senescence and apoptosis in normal human fibroblasts. / 2018 / PubMed / Full text
A stably self-renewing adult blood-derived induced neural stem cell exhibiting patternability and epigenetic rejuvenation. / 02.10.2018 / PubMed / Full text
O-GlcNAcylation is required for mutant KRAS-induced lung tumorigenesis. / 01.11.2018 / PubMed / Full text
Centenarians Overexpress Pluripotency-Related Genes. / 16.08.2019 / PubMed / Full text
E47 Governs the MYC-CDKN1B/p27 -RB Network to Growth Arrest PDA Cells Independent of CDKN2A/p16 and Wild-Type p53. / 2018 / PubMed / Full text
Integrative Analysis of Hippocampus Gene Expression Profiles Identifies Network Alterations in Aging and Alzheimer's Disease. / 2018 / PubMed / Full text
MYC Releases Early Reprogrammed Human Cells from Proliferation Pause via Retinoblastoma Protein Inhibition. / 10.04.2018 / PubMed / Full text
Regulation of Cellular Senescence by Polycomb Chromatin Modifiers through Distinct DNA Damage- and Histone Methylation-Dependent Pathways. / 27.03.2018 / PubMed / Full text
Metformin regulates metabolic and nonmetabolic pathways in skeletal muscle and subcutaneous adipose tissues of older adults. / 04.2018 / PubMed / Full text
Modulation of dietary folate with age confers selective hepatocellular epigenetic imprints through DNA methylation. / 03.2018 / PubMed / Full text
Proline Metabolism in Cell Regulation and Cancer Biology: Recent Advances and Hypotheses. / 01.02.2019 / PubMed / Full text
MYC Modulation around the CDK2/p27/SKP2 Axis. / 30.06.2017 / PubMed / Full text
Induced Pluripotent Stem Cell-Derived Dopaminergic Neurons from Adult Common Marmoset Fibroblasts. / 01.09.2017 / PubMed / Full text
Nickel-induced HIF-1α promotes growth arrest and senescence in normal human cells but lacks toxic effects in transformed cells. / 15.09.2017 / PubMed / Full text
Role of p16 and BMI-1 in oxidative stress-induced premature senescence in human dental pulp stem cells. / 08.2017 / PubMed / Full text
The RUNX Genes as Conditional Oncogenes: Insights from Retroviral Targeting and Mouse Models. / 2017 / PubMed / Full text
Protection against High-Fat-Diet-Induced Obesity in MDM2 Mice Due to Reduced p53 Activity and Enhanced Energy Expenditure. / 24.01.2017 / PubMed / Full text
Downregulation of CITED2 contributes to TGFβ-mediated senescence of tendon-derived stem cells. / 04.2017 / PubMed / Full text
STAT3-mediated SMAD3 activation underlies Oncostatin M-induced Senescence. / 16.02.2017 / PubMed / Full text
Synchronous deficits in cumulative muscle protein synthesis and ribosomal biogenesis underlie age-related anabolic resistance to exercise in humans. / 15.12.2016 / PubMed / Full text
Bromodomain and Extraterminal Protein Inhibition Blocks Growth of Triple-negative Breast Cancers through the Suppression of Aurora Kinases. / 04.11.2016 / PubMed / Full text
Mitochondrial function in hypoxic ischemic injury and influence of aging. / 10.2017 / PubMed / Full text
JAZ7 negatively regulates dark-induced leaf senescence in Arabidopsis. / 02.2016 / PubMed / Full text
ARF: connecting senescence and innate immunity for clearance. / 09.2015 / PubMed / Full text
Reduced expression of MYC increases longevity and enhances healthspan. / 29.01.2015 / PubMed / Full text
Immortalization of normal human mammary epithelial cells in two steps by direct targeting of senescence barriers does not require gross genomic alterations. / 2014 / PubMed / Full text
DNA and RNA quadruplex-binding proteins. / 29.09.2014 / PubMed / Full text
Aging and injury: alterations in cellular energetics and organ function. / 04.2014 / PubMed / Full text
PLA2R1: expression and function in cancer. / 08.2014 / PubMed / Full text
Senescence-secreted factors activate Myc and sensitize pretransformed cells to TRAIL-induced apoptosis. / 06.2014 / PubMed / Full text

PSDПравить

Quantitative Immunoblotting Analyses Reveal that the Abundance of Actin, Tubulin, Synaptophysin and EEA1 Proteins is Altered in the Brains of Aged Mice. / 21.08.2020 / PubMed / Full text
Exercise Attenuates Brain Aging by Rescuing Down-Regulated Wnt/β-Catenin Signaling in Aged Rats. / 2020 / PubMed / Full text
Concurrent nicotine exposure to prenatal alcohol consumption alters the hippocampal and cortical neurotoxicity. / 01.2020 / PubMed / Full text
The Experience of Family Physicians and Home Health Staff Involved in an Intervention to Increase Patient-Related Collaboration. / 12.2019 / PubMed / Full text
Pterostilbene Improves Cognitive Performance in Aged Rats: An in Vivo Study. / 2019 / PubMed / Full text
Higher Levels of Protein Palmitoylation in the Frontal Cortex across Aging Were Associated with Reference Memory and Executive Function Declines. / 01-02.2019 / PubMed / Full text
A single cocaine administration alters dendritic spine morphology and impairs glutamate receptor synaptic retention in the medial prefrontal cortex of adolescent rats. / 15.09.2018 / PubMed / Full text
Differential effects of adolescent and adult-initiated voluntary exercise on context and cued fear conditioning. / 02.2019 / PubMed / Full text
Dynamic SAP102 expression in the hippocampal subregions of rats and APP/PS1 mice of various ages. / 06.2018 / PubMed / Full text
Downregulated Nuclear Factor E2-Related Factor 2 (Nrf2) Aggravates Cognitive Impairments via Neuroinflammation and Synaptic Plasticity in the Senescence-Accelerated Mouse Prone 8 (SAMP8) Mouse: A Model of Accelerated Senescence. / 23.02.2018 / PubMed / Full text
Development of Glutamatergic Proteins in Human Visual Cortex across the Lifespan. / 21.06.2017 / PubMed / Full text
Spinal and corticospinal pathways are differently modulated when standing at the bottom and the top of a three-step staircase in young and older adults. / 06.2017 / PubMed / Full text
Aging alters the molecular dynamics of synapses in a sexually dimorphic pattern in zebrafish (Danio rerio). / 06.2017 / PubMed / Full text
Subacute ibuprofen treatment rescues the synaptic and cognitive deficits in advanced-aged mice. / 05.2017 / PubMed / Full text
Strength and Aerobic Exercises Improve Spatial Memory in Aging Rats Through Stimulating Distinct Neuroplasticity Mechanisms. / 12.2017 / PubMed / Full text
Age-Associated Changes in the Spectral and Statistical Parameters of Surface Electromyogram of Tibialis Anterior. / 2016 / PubMed / Full text
Diverse Synaptic Distributions of G Protein-coupled Estrogen Receptor 1 in Monkey Prefrontal Cortex with Aging and Menopause. / 01.03.2017 / PubMed / Full text
BDNF pathway is involved in the protective effects of SS-31 on isoflurane-induced cognitive deficits in aging mice. / 15.05.2016 / PubMed / Full text
Multiplex analyte assays to characterize different dementias: brain inflammatory cytokines in poststroke and other dementias. / 02.2016 / PubMed / Full text
Alzheimer's disease-like APP processing in wild-type mice identifies synaptic defects as initial steps of disease progression. / 12.01.2016 / PubMed / Full text
Adaptive Plasticity in the Hippocampus of Young Mice Intermittently Exposed to MDMA Could Be the Origin of Memory Deficits. / 12.2016 / PubMed / Full text
Lactational exposure of mice to low levels of non-dioxin-like polychlorinated biphenyls increases susceptibility to neuronal stress at a mature age. / 03.2016 / PubMed / Full text
Selective Brain-Targeted Antagonism of p38 MAPKα Reduces Hippocampal IL-1β Levels and Improves Morris Water Maze Performance in Aged Rats. / 2015 / PubMed / Full text
Partial sleep deprivation activates the DNA damage response (DDR) and the senescence-associated secretory phenotype (SASP) in aged adult humans. / 01.2016 / PubMed / Full text
Paradoxical sleep deprivation impairs mouse survival after infection with malaria parasites. / 28.04.2015 / PubMed / Full text
Adolescent intermittent alcohol exposure: persistence of structural and functional hippocampal abnormalities into adulthood. / 06.2015 / PubMed / Full text
APOE4 enhances age-dependent decline in cognitive function by down-regulating an NMDA receptor pathway in EFAD-Tg mice. / 05.03.2015 / PubMed / Full text
Minocycline enhances hippocampal memory, neuroplasticity and synapse-associated proteins in aged C57 BL/6 mice. / 05.2015 / PubMed / Full text
Cardiac autonomic changes in middle-aged women: identification based on principal component analysis. / 07.2016 / PubMed / Full text
Tau-mediated NMDA receptor impairment underlies dysfunction of a selectively vulnerable network in a mouse model of frontotemporal dementia. / 03.12.2014 / PubMed / Full text
Post-stroke depression and the aging brain. / 2013 / PubMed / Full text
A framework to understand the variations of PSD-95 expression in brain aging and in Alzheimer's disease. / 11.2014 / PubMed / Full text
The effects of aging on the BTBR mouse model of autism spectrum disorder. / 2014 / PubMed / Full text
Repetitive transcranial magnetic stimulation (rTMS) influences spatial cognition and modulates hippocampal structural synaptic plasticity in aging mice. / 10.2014 / PubMed / Full text
Progressive axonal transport and synaptic protein changes correlate with behavioral and neuropathological abnormalities in the heterozygous Q175 KI mouse model of Huntington's disease. / 01.09.2014 / PubMed / Full text
Neuron volumes in hippocampal subfields in delayed poststroke and aging-related dementias. / 04.2014 / PubMed / Full text

ATRПравить

Bloodstain age estimation through infrared spectroscopy and Chemometric models. / 11.2020 / PubMed / Full text
Artificial Intelligence and fourier-transform infrared spectroscopy for evaluating water-mediated degradation of lubricant oils. / 01.11.2020 / PubMed / Full text
Senescence Induction by Combined Ionizing Radiation and DNA Damage Response Inhibitors in Head and Neck Squamous Cell Carcinoma Cells. / 01.09.2020 / PubMed / Full text
Kinetics of thermal degradation and lifetime study of poly(vinylidene fluoride) (PVDF) subjected to bioethanol fuel accelerated aging. / 07.2020 / PubMed / Full text
Supraphysiological protection from replication stress does not extend mammalian lifespan. / 06.04.2020 / PubMed / Full text
Assessing the Retest Reliability of Prefrontal EEG Markers of Brain Rhythm Slowing in the Eyes-Closed Resting State. / 09.2020 / PubMed / Full text
Effects of Hydrogen Peroxide and Sodium Hypochlorite Aging on Properties and Performance of Polyethersulfone Ultrafiltration Membrane. / 18.10.2019 / PubMed / Full text
NF-κB signaling in skin aging. / 12.2019 / PubMed / Full text
Development of a w/o emulsion using ionic liquid strategy for transdermal delivery of anti - aging component α - lipoic acid: Mechanism of different ionic liquids on skin retention and efficacy evaluation. / 01.01.2020 / PubMed / Full text
Effect of Nitrogen-Doped Graphene Oxide on the Aging Behavior of Nitrile-Butadiene Rubber. / 10.10.2019 / PubMed / Full text
Age-related dysfunction of the DNA damage response in intestinal stem cells. / 2019 / PubMed / Full text
Age-related variations in corneal geometry and their association with astigmatism: The Yamagata Study (Funagata). / 10.2018 / PubMed / Full text
Sex-related differences in corneal astigmatism and shape with age. / 09.2018 / PubMed / Full text
Aging-Resistant Functionalized LDH⁻SAS/Nitrile-Butadiene Rubber Composites: Preparation and Study of Aging Kinetics/Anti-Aging Mechanism. / 18.05.2018 / PubMed / Full text
[Protective effect of Wuzi Yanzong recipe on testicular DNA damage and apoptosis in natural ageing rats]. / 04.2018 / PubMed / Full text
Age-related changes in with-the-rule and oblique corneal astigmatism. / 09.2018 / PubMed / Full text
Investigation of the factors that influence lead accumulation onto polyethylene: Implication for potable water plumbing pipes. / 05.04.2018 / PubMed / Full text
Global mapping of transcription factor motifs in human aging. / 2018 / PubMed / Full text
Cross-Sectional and Longitudinal Investigation of the Power Vector in Astigmatism: The Yamagata Study (Funagata). / 01.2018 / PubMed / Full text
Glomerular and tubular effects of nitric oxide (NO) are regulated by angiotensin II (Ang II) in an age-dependent manner through activation of both angiotensin receptors (AT1Rs and AT2Rs) in conscious lambs. / 02.2018 / PubMed / Full text
Progerin-Induced Replication Stress Facilitates Premature Senescence in Hutchinson-Gilford Progeria Syndrome. / 15.07.2017 / PubMed / Full text
Increasing age in Achilles rupture patients over time. / 07.2017 / PubMed / Full text
Phospholipid-protein balance in affective disorders: Analysis of human blood serum using Raman and FTIR spectroscopy. A pilot study. / 30.11.2016 / PubMed / Full text
Dysfunctional telomeres induce p53-dependent and independent apoptosis to compromise cellular proliferation and inhibit tumor formation. / 08.2016 / PubMed / Full text
Relationship between age, corneal astigmatism, and ocular dimensions with reference to astigmatism in eyes undergoing routine cataract surgery. / 04.2016 / PubMed / Full text
The DNA damage response induces inflammation and senescence by inhibiting autophagy of GATA4. / 25.09.2015 / PubMed / Full text
Analysis of anterior corneal astigmatism before cataract surgery using power vector analysis in eyes of Korean patients. / 06.2015 / PubMed / Full text
Requirement of ATR for maintenance of intestinal stem cells in aging Drosophila. / 05.2015 / PubMed / Full text
Ambient temperature reduction extends lifespan via activating cellular degradation activity in an annual fish (Nothobranchius rachovii). / 2015 / PubMed / Full text
Increased Rrm2 gene dosage reduces fragile site breakage and prolongs survival of ATR mutant mice. / 01.04.2015 / PubMed / Full text
MDM2 turnover and expression of ATRX determine the choice between quiescence and senescence in response to CDK4 inhibition. / 10.04.2015 / PubMed / Full text
Structural investigation of donor age effect on human bone marrow mesenchymal stem cells: FTIR spectroscopy and imaging. / 2014 / PubMed / Full text
Gestational and lactational exposure to atrazine via the drinking water causes specific behavioral deficits and selectively alters monoaminergic systems in C57BL/6 mouse dams, juvenile and adult offspring. / 09.2014 / PubMed / Full text
Age-dependent dopaminergic dysfunction following fetal exposure to atrazine in SD rats. / 05.2014 / PubMed / Full text
Molecular characterization of collaborator of ARF (CARF) as a DNA damage response and cell cycle checkpoint regulatory protein. / 01.04.2014 / PubMed / Full text

NGFПравить

Dietary fish hydrolysate supplementation containing n-3 LC-PUFAs and peptides prevents short-term memory and stress response deficits in aged mice. / 23.09.2020 / PubMed / Full text
Imbalance of nerve growth factor metabolism in aging women with overactive bladder syndrome. / 01.09.2020 / PubMed / Full text
Parity Attenuates Intraepithelial Corneal Sensory Nerve Loss in Female Mice. / 21.07.2020 / PubMed / Full text
Cholinergic System and NGF Receptors: Insights from the Brain of the Short-Lived Fish [i]Nothobranchius furzeri[/i]. / 20.06.2020 / PubMed / Full text
Retrograde axonal transport of BDNF and proNGF diminishes with age in basal forebrain cholinergic neurons. / 12.2019 / PubMed / Full text
C-SH2 point mutation converts p85β regulatory subunit of phosphoinositide 3-kinase to an anti-aging gene. / 03.09.2019 / PubMed / Full text
[i]Hericium erinaceus[/i] Mycelium and Its Isolated Compound, Erinacine A, Ameliorate High-Fat High-Sucrose Diet-Induced Metabolic Dysfunction and Spatial Learning Deficits in Aging Mice. / 05.2019 / PubMed / Full text
Morphological and immunohistochemical characteristics of the equine corneal epithelium. / 11.2019 / PubMed / Full text
Ectopic nerve growth factor prevents proliferation in glioma cells by senescence induction. / 05.2019 / PubMed / Full text
Mechanisms Underlying the Regulation of HP1γ by the NGF-PKA Signaling Pathway. / 10.10.2018 / PubMed / Full text
Insulin-like growth factor-1 acts as a zeitgeber on hypothalamic circadian clock gene expression via glycogen synthase kinase-3β signaling. / 02.11.2018 / PubMed / Full text
Nasal delivery of nerve growth factor rescue hypogonadism by up-regulating GnRH and testosterone in aging male mice. / 09.2018 / PubMed / Full text
Evidence for changing nerve growth factor signalling mechanisms during development, maturation and ageing in the rat molar pulp. / 02.2019 / PubMed / Full text
Reduced NGF in Gastric Endothelial Cells Is One of the Main Causes of Impaired Angiogenesis in Aging Gastric Mucosa. / 2018 / PubMed / Full text
Anti-nerve growth factor does not change physical activity in normal young or aging mice but does increase activity in mice with skeletal pain. / 11.2018 / PubMed / Full text
Effects of cerebrolysin on nerve growth factor system in the aging rat brain. / 2017 / PubMed / Full text
Immunohistochemical localization of nerve growth factor, tropomyosin receptor kinase A, and p75 in the bone and articular cartilage of the mouse femur. / 01-12.2017 / PubMed / Full text
Differential deregulation of NGF and BDNF neurotrophins in a transgenic rat model of Alzheimer's disease. / 12.2017 / PubMed / Full text
Noni (Morinda citrifolia L.) fruit juice reverses age-related decline in neural-immune interactions in the spleens of old F344 rats. / 23.02.2017 / PubMed / Full text
Morphine exposure during early life alters thermal and mechanical thresholds in rats. / 08.2017 / PubMed / Full text
Age-Related (Aged vs. Adult) Comparison of the Effect of Two Mild Stressors on the Nerve Growth Factor (NGF) in the Rat Hypothalamic Supraoptic Nucleus (SON) - Immunohistochemical Study. / 2016 / PubMed
The effects of short-term JNK inhibition on the survival and growth of aged sympathetic neurons. / 10.2016 / PubMed / Full text
Estrogen-induced neuroprotective and anti-inflammatory effects are dependent on the brain areas of middle-aged female rats. / 06.2016 / PubMed / Full text
Increased ZAP70 Is Involved in Dry Skin Pruritus in Aged Mice. / 2016 / PubMed / Full text
The impact of two mild stressors on the nerve growth factor (NGF) immunoreactivity in the amygdala in aged rats compared to adult ones. / 04.2016 / PubMed / Full text
Prolonged metformin treatment leads to reduced transcription of Nrf2 and neurotrophic factors without cognitive impairment in older C57BL/6J mice. / 15.03.2016 / PubMed / Full text
High-pressure physiological saline isotonic solution administration enhances brain NGF and NGF-receptors expression. / 10.2015 / PubMed
The involvement of BDNF, NGF and GDNF in aging and Alzheimer's disease. / 09.2015 / PubMed / Full text
The Relationship Between Variation in Size of the Primordial Follicle Pool and Age at Natural Menopause. / 06.2015 / PubMed / Full text
Time dynamics of protein complexes in the AD11 transgenic mouse model for Alzheimer's disease like pathology. / 29.04.2015 / PubMed / Full text
Critical role of the miR-200 family in regulating differentiation and proliferation of neurons. / 06.2015 / PubMed / Full text
The effect of mild stress stimulation on the nerve growth factor (NGF) and tyrosine kinase receptor A (TrkA) immunoreactivity in the paraventricular nucleus (PVN) of the hypothalamus and hippocampus in aged vs. adult rats. / 02.04.2015 / PubMed / Full text
Nerve growth factor in the adult brain of a teleostean model for aging research: Nothobranchius furzeri. / 07.2014 / PubMed / Full text
Age-dependent effects of valproic acid in Alzheimer's disease (AD) mice are associated with nerve growth factor (NGF) regulation. / 25.04.2014 / PubMed / Full text
Validation of the power model of ovarian nongrowing follicle depletion associated with aging in women. / 03.2014 / PubMed / Full text

STSПравить

Delayed Impairment of Postural, Physical, and Muscular Functions Following Downhill Compared to Level Walking in Older People. / 2020 / PubMed / Full text
Autophagy displays divergent roles during intermittent amino acid starvation and toxic stress-induced senescence in cultured skeletal muscle cells. / 06.10.2020 / PubMed / Full text
The WRKY53 transcription factor enhances stilbene synthesis and disease resistance by interacting with MYB14 and MYB15 in Chinese wild grape. / 30.05.2020 / PubMed / Full text
On the role of ageing and musculoskeletal pain on dynamic balance in manual workers. / 02.2020 / PubMed / Full text
30-day mortality in frail patients undergoing cardiac surgery: the results of the [i]frailty in cardiac surgery (FICS) copenhagen study[/i]. / 12.2019 / PubMed / Full text
Chronic Fish Oil Consumption with Resistance Training Improves Grip Strength, Physical Function, and Blood Pressure in Community-Dwelling Older Adults. / 09.07.2019 / PubMed / Full text
Effects of Tai Chi versus Taekkyon on balance, lower-extremity strength, and gait ability in community-dwelling older women: A single-blinded randomized clinical trial. / 2020 / PubMed / Full text
Short-term starvation stress at young adult stages enhances meiotic activity of germ cells to maintain spermatogenesis in aged male Caenorhabditis elegans. / 06.2019 / PubMed / Full text
Flexibility in joint coordination remains unaffected by force and balance demands in young and old adults during simple sit-to-stand tasks. / 02.2019 / PubMed / Full text
The influence of knee extensor fatigue on lower extremity muscle activity during chair rise in young and older adults. / 01.2019 / PubMed / Full text
The sit-to-stand muscle power test: An easy, inexpensive and portable procedure to assess muscle power in older people. / 02.10.2018 / PubMed / Full text
Visual-Vestibular Interaction for Postural Control During Sit-to-Stand: Effects of Aging. / 01.01.2019 / PubMed / Full text
From Intervention to Co-constitution: New Directions in Theorizing about Aging and Technology. / 09.01.2019 / PubMed / Full text
Age-related Changes in Postural Sway During Sit-to-stand in Typical Children and Children with Cerebral Palsy. / 2019 / PubMed / Full text
Ectopic expression of VpSTS29, a stilbene synthase gene from Vitis pseudoreticulata, indicates STS presence in cytosolic oil bodies. / 07.2018 / PubMed / Full text
Short-Term Training and Detraining Effects of Supervised vs. Unsupervised Resistance Exercise in Aging Adults. / 10.2019 / PubMed / Full text
The coordination of joint movements during sit-to-stand motion in old adults: the uncontrolled manifold analysis. / 2017 / PubMed / Full text
The role of thigh muscular efforts in limiting sit-to-stand capacity in healthy young and older adults. / 12.2017 / PubMed / Full text
Hippocampal structure predicts cortical indices of reactivation of related items. / 27.01.2017 / PubMed / Full text
Aortic Valve Replacement With or Without Concurrent Coronary Artery Bypass Grafting in Octogenarians: Eight-Year Cohort Study. / 01.2017 / PubMed / Full text
Anatomical cross-sectional area of the quadriceps femoris and sit-to-stand test score in middle-aged and elderly population: development of a predictive equation. / 29.06.2016 / PubMed / Full text
Association between Physical Fitness and Successful Aging in Taiwanese Older Adults. / 2016 / PubMed / Full text
Is this STS work-related? ISO 1999 predictions as an adjunct to clinical judgment. / 12.2015 / PubMed / Full text
Effects of Strength Training Using Unstable Surfaces on Strength, Power and Balance Performance Across the Lifespan: A Systematic Review and Meta-analysis. / 12.2015 / PubMed / Full text
Lean Body Mass Associated with Upper Body Strength in Healthy Older Adults While Higher Body Fat Limits Lower Extremity Performance and Endurance. / 26.08.2015 / PubMed / Full text
Psychometric properties of the Swedish version of the Self-Transcendence Scale among very old people. / 2015 / PubMed / Full text
Age-related changes in intrinsic function of the superior temporal sulcus in autism spectrum disorders. / 10.2015 / PubMed / Full text
Effects of Age and Estradiol on Gene Expression in the Rhesus Macaque Hypothalamus. / 2015 / PubMed / Full text
Kinematic analysis of motor strategies in frail aged adults during the Timed Up and Go: how to spot the motor frailty? / 2015 / PubMed / Full text
Sit-to-stand test: Performance and determinants across the age-span. / 2010 / PubMed / Full text
Developing a measure of muscular power during a functional task for older adults. / 30.12.2014 / PubMed / Full text
Behavior and neural correlates of empathy in adolescents. / 2014 / PubMed / Full text
Can sit-to-stand lower limb muscle power predict fall status? / 07.2014 / PubMed / Full text
Physical working capacity at fatigue threshold (PWCFT) is associated with sarcopenia-related body composition and measures of functionality in older adults. / 09-10.2014 / PubMed / Full text
Expression of an AtNAP gene homolog in senescing morning glory (Ipomoea nil) petals of two cultivars with a different flower life span. / 01.05.2014 / PubMed / Full text

CD38Править

Re-equilibration of imbalanced NAD metabolism ameliorates the impact of telomere dysfunction. / 02.11.2020 / PubMed / Full text
TNFRSF12A and CD38 Contribute to a Vicious Circle for Chronic Obstructive Pulmonary Disease by Engaging Senescence Pathways. / 2020 / PubMed / Full text
Aging alters acetylation status in skeletal and cardiac muscles. / 06.2020 / PubMed / Full text
CD38 in Neurodegeneration and Neuroinflammation. / 18.02.2020 / PubMed / Full text
CD38, a Receptor with Multifunctional Activities: From Modulatory Functions on Regulatory Cell Subsets and Extracellular Vesicles, to a Target for Therapeutic Strategies. / 27.11.2019 / PubMed / Full text
CD38 Deficiency Alleviates D-Galactose-Induced Myocardial Cell Senescence Through NAD /Sirt1 Signaling Pathway. / 2019 / PubMed / Full text
The Multi-faceted Ecto-enzyme CD38: Roles in Immunomodulation, Cancer, Aging, and Metabolic Diseases. / 2019 / PubMed / Full text
Interacting NAD and Cell Senescence Pathways Complicate Antiaging Therapies. / 06.2019 / PubMed / Full text
The NADase CD38 is induced by factors secreted from senescent cells providing a potential link between senescence and age-related cellular NAD decline. / 28.05.2019 / PubMed / Full text
Measuring CD38 Hydrolase and Cyclase Activities: 1,N -Ethenonicotinamide Adenine Dinucleotide (ε-NAD) and Nicotinamide Guanine Dinucleotide (NGD) Fluorescence-based Methods. / 20.07.2018 / PubMed / Full text
The Plasma NAD Metabolome Is Dysregulated in "Normal" Aging. / 04.2019 / PubMed / Full text
Assays for NAD -Dependent Reactions and NAD Metabolites. / 2018 / PubMed / Full text
Decreased NAD Activates STAT3 and Integrin Pathways to Drive Epithelial-Mesenchymal Transition. / 10.2018 / PubMed / Full text
Innate and adaptive immune dysregulation in critically ill ICU patients. / 05.07.2018 / PubMed / Full text
Abnormalities of age-related T cell senescence in Parkinson's disease. / 28.05.2018 / PubMed / Full text
A Potent and Specific CD38 Inhibitor Ameliorates Age-Related Metabolic Dysfunction by Reversing Tissue NAD Decline. / 01.05.2018 / PubMed / Full text
Role of Nicotinamide Adenine Dinucleotide and Related Precursors as Therapeutic Targets for Age-Related Degenerative Diseases: Rationale, Biochemistry, Pharmacokinetics, and Outcomes. / 10.01.2019 / PubMed / Full text
Hyper-Expression of PD-1 Is Associated with the Levels of Exhausted and Dysfunctional Phenotypes of Circulating CD161 TCR iVα7.2 Mucosal-Associated Invariant T Cells in Chronic Hepatitis B Virus Infection. / 2018 / PubMed / Full text
The Pharmacology of CD38/NADase: An Emerging Target in Cancer and Diseases of Aging. / 04.2018 / PubMed / Full text
NAD Deficiency Is a Common Central Pathological Factor of a Number of Diseases and Aging: Mechanisms and Therapeutic Implications. / 20.02.2019 / PubMed / Full text
Reevaluation of immune activation in the era of cART and an aging HIV-infected population. / 19.10.2017 / PubMed / Full text
Altered marginal zone and innate-like B cells in aged senescence-accelerated SAMP8 mice with defective IgG1 responses. / 17.08.2017 / PubMed / Full text
Age dependent differences in the kinetics of γδ T cells after influenza vaccination. / 2017 / PubMed / Full text
NAD and the aging process: Role in life, death and everything in between. / 05.11.2017 / PubMed / Full text
Constitutive Expression of Inducible Cyclic Adenosine Monophosphate Early Repressor (ICER) in Cycling Quiescent Hematopoietic Cells: Implications for Aging Hematopoietic Stem Cells. / 02.2017 / PubMed / Full text
Why NAD( ) Declines during Aging: It's Destroyed. / 14.06.2016 / PubMed / Full text
CD38 Dictates Age-Related NAD Decline and Mitochondrial Dysfunction through an SIRT3-Dependent Mechanism. / 14.06.2016 / PubMed / Full text
Immunity in young adult survivors of childhood leukemia is similar to the elderly rather than age-matched controls: Role of cytomegalovirus. / 07.2016 / PubMed / Full text
Aging of immune system: Immune signature from peripheral blood lymphocyte subsets in 1068 healthy adults. / 05.2016 / PubMed / Full text
Peripheral loss of CD8( ) CD161( ) TCRVα7·2( ) mucosal-associated invariant T cells in chronic hepatitis C virus-infected patients. / 02.2016 / PubMed / Full text
Probiotics Reduce Inflammation in Antiretroviral Treated, HIV-Infected Individuals: Results of the "Probio-HIV" Clinical Trial. / 2015 / PubMed / Full text
Concurrent loss of co-stimulatory molecules and functional cytokine secretion attributes leads to proliferative senescence of CD8( ) T cells in HIV/TB co-infection. / 09.2015 / PubMed / Full text

BACE1Править

Electric Stimulation of Neurogenesis Improves Behavioral Recovery After Focal Ischemia in Aged Rats. / 2020 / PubMed / Full text
Disruption of synaptic expression pattern and age-related DNA oxidation in a neuronal model of lead-induced toxicity. / 05.2020 / PubMed / Full text
Age- and sex-dependent profiles of APP fragments and key secretases align with changes in despair-like behavior and cognition in young APPSwe/Ind mice. / 02.04.2019 / PubMed / Full text
Selective reduction of APP-BACE1 activity improves memory via NMDA-NR2B receptor-mediated mechanisms in aged PDAPP mice. / 03.2019 / PubMed / Full text
Temporal Effects of Neuron-specific beta-secretase 1 (BACE1) Knock-in on the Mouse Brain Metabolome: Implications for Alzheimer's Disease. / 15.01.2019 / PubMed / Full text
Removal of p75 Neurotrophin Receptor Expression from Cholinergic Basal Forebrain Neurons Reduces Amyloid-β Plaque Deposition and Cognitive Impairment in Aged APP/PS1 Mice. / 07.2019 / PubMed / Full text
Axonal organization defects in the hippocampus of adult conditional BACE1 knockout mice. / 19.09.2018 / PubMed / Full text
Biliverdin reductase-A impairment links brain insulin resistance with increased Aβ production in an animal model of aging: Implications for Alzheimer disease. / 10.2018 / PubMed / Full text
Effects of senescence and angiotensin II on expression and processing of amyloid precursor protein in human cerebral microvascular endothelial cells. / 15.01.2018 / PubMed / Full text
Neuroprotective potential of high-dose biotin. / 11.2017 / PubMed / Full text
The pathological roles of NDRG2 in Alzheimer's disease, a study using animal models and APPwt-overexpressed cells. / 08.2017 / PubMed / Full text
Ferulic Acid Suppresses Amyloid [i]β[/i] Production in the Human Lens Epithelial Cell Stimulated with Hydrogen Peroxide. / 2017 / PubMed / Full text
Vitamin D Combined with Resveratrol Prevents Cognitive Decline in SAMP8 Mice. / 2017 / PubMed / Full text
Prevention of tau increase in cerebrospinal fluid of APP transgenic mice suggests downstream effect of BACE1 inhibition. / 06.2017 / PubMed / Full text
Fuzhisan Ameliorates the Memory Deficits in Aged SAMP8 Mice via Decreasing Aβ Production and Tau Hyperphosphorylation of the Hippocampus. / 11.2016 / PubMed / Full text
Behaviour and cognitive changes correlated with hippocampal neuroinflammaging and neuronal markers in female SAMP8, a model of accelerated senescence. / 07.2016 / PubMed / Full text
Partial BACE1 reduction in a Down syndrome mouse model blocks Alzheimer-related endosomal anomalies and cholinergic neurodegeneration: role of APP-CTF. / 03.2016 / PubMed / Full text
miR-186 is decreased in aged brain and suppresses BACE1 expression. / 05.2016 / PubMed / Full text
IL-17A is implicated in lipopolysaccharide-induced neuroinflammation and cognitive impairment in aged rats via microglial activation. / 15.09.2015 / PubMed / Full text
Functions of miR-9 and miR-9* during Aging in SAMP8 Mice and Their Possible Mechanisms. / 06.2015 / PubMed / Full text
SNX15 Regulates Cell Surface Recycling of APP and Aβ Generation. / 08.2016 / PubMed / Full text
Non-neuronal and neuronal BACE1 elevation in association with angiopathic and leptomeningeal β-amyloid deposition in the human brain. / 02.05.2015 / PubMed / Full text
The flavonoid quercetin ameliorates Alzheimer's disease pathology and protects cognitive and emotional function in aged triple transgenic Alzheimer's disease model mice. / 06.2015 / PubMed / Full text
Elevation of brain magnesium prevents synaptic loss and reverses cognitive deficits in Alzheimer's disease mouse model. / 13.09.2014 / PubMed / Full text
Development and characterization of an aged onset model of Alzheimer's disease in Drosophila melanogaster. / 11.2014 / PubMed / Full text
Sildenafil Decreases BACE1 and Cathepsin B Levels and Reduces APP Amyloidogenic Processing in the SAMP8 Mouse. / 06.2015 / PubMed / Full text
Oxidized LDL lipids increase β-amyloid production by SH-SY5Y cells through glutathione depletion and lipid raft formation. / 10.2014 / PubMed / Full text
Increased mtDNA mutations with aging promotes amyloid accumulation and brain atrophy in the APP/Ld transgenic mouse model of Alzheimer's disease. / 02.05.2014 / PubMed / Full text
Lessons from a BACE1 inhibitor trial: off-site but not off base. / 10.2014 / PubMed / Full text
Expression of amyloid-associated miRNAs in both the forebrain cortex and hippocampus of middle-aged rat. / 2014 / PubMed / Full text

CDK4Править

Emerging Roles for the [i]INK4a/ARF[/i] ([i]CDKN2A[/i]) Locus in Adipose Tissue: Implications for Obesity and Type 2 Diabetes. / 22.09.2020 / PubMed / Full text
Guilu Erxian Glue () Inhibits Chemotherapy-Induced Bone Marrow Hematopoietic Stem Cell Senescence in Mice May via p16 -Rb Signaling Pathway. / 11.2020 / PubMed / Full text
Induction of Senescence in Cancer Cells by a Novel Combination of Cucurbitacin B and Withanone: Molecular Mechanism and Therapeutic Potential. / 22.05.2020 / PubMed / Full text
Ribosomal protein RPL22/eL22 regulates the cell cycle by acting as an inhibitor of the CDK4-cyclin D complex. / 03-04.2019 / PubMed / Full text
p16 deletion in cells of the intervertebral disc affects their matrix homeostasis and senescence associated secretory phenotype without altering onset of senescence. / 09.2019 / PubMed / Full text
Efficient immortalization of cells derived from critically endangered Tsushima leopard cat (Prionailurus bengalensis euptilurus) with expression of mutant CDK4, Cyclin D1, and telomerase reverse transcriptase. / 12.2018 / PubMed / Full text
Effects of Fibronectin 1 on Cell Proliferation, Senescence and Apoptosis of Human Glioma Cells Through the PI3K/AKT Signaling Pathway. / 2018 / PubMed / Full text
Cyclin D1 depletion interferes with oxidative balance and promotes cancer cell senescence. / 25.06.2018 / PubMed / Full text
Fucoidan Rescues p-Cresol-Induced Cellular Senescence in Mesenchymal Stem Cells via FAK-Akt-TWIST Axis. / 06.04.2018 / PubMed / Full text
Carvacrol nanoemulsion evokes cell cycle arrest, apoptosis induction and autophagy inhibition in doxorubicin resistant-A549 cell line. / 2018 / PubMed / Full text
Mechanistic understanding of the role of ATRX in senescence provides new insight for combinatorial therapies with CDK4 inhibitors. / 2018 / PubMed / Full text
Glutaredoxin-1 Silencing Induces Cell Senescence via p53/p21/p16 Signaling Axis. / 02.03.2018 / PubMed / Full text
Inhibition of CIP2A attenuates tumor progression by inducing cell cycle arrest and promoting cellular senescence in hepatocellular carcinoma. / 08.01.2018 / PubMed / Full text
Preclinical characterization of abemaciclib in hormone receptor positive breast cancer. / 19.09.2017 / PubMed / Full text
Immortalized prairie vole-derived fibroblasts (VMF-K4DTs) can be transformed into pluripotent stem cells and provide a useful tool with which to determine optimal reprogramming conditions. / 21.06.2017 / PubMed / Full text
Molecular mechanism of G arrest and cellular senescence induced by LEE011, a novel CDK4/CDK6 inhibitor, in leukemia cells. / 2017 / PubMed / Full text
p16 loss rescues functional decline of Brca1-deficient mammary stem cells. / 18.04.2017 / PubMed / Full text
p16 enhances the transcriptional and the apoptotic functions of p53 through DNA-dependent interaction. / 07.2017 / PubMed / Full text
p16INK4a suppresses BRCA1-deficient mammary tumorigenesis. / 20.12.2016 / PubMed / Full text
A steroid like phytochemical Antcin M is an anti-aging reagent that eliminates hyperglycemia-accelerated premature senescence in dermal fibroblasts by direct activation of Nrf2 and SIRT-1. / 27.09.2016 / PubMed / Full text
CDK4-CDK6 inhibitors induce autophagy-mediated degradation of DNMT1 and facilitate the senescence antitumor response. / 02.10.2016 / PubMed / Full text
Sperm-associated antigen 9 (SPAG9) promotes the survival and tumor growth of triple-negative breast cancer cells. / 10.2016 / PubMed / Full text
Double staining of β-galactosidase with fibrosis and cancer markers reveals the chronological appearance of senescence in liver carcinogenesis induced by diethylnitrosamine. / 22.01.2016 / PubMed / Full text
Efficacy of CDK4 inhibition against sarcomas depends on their levels of CDK4 and p16ink4 mRNA. / 01.12.2015 / PubMed / Full text
Suppression of RAD21 Induces Senescence of MDA-MB-231 Human Breast Cancer Cells Through RB1 Pathway Activation Via c-Myc Downregulation. / 06.2016 / PubMed / Full text
Molecular differences between stromal cell populations from deciduous and permanent human teeth. / 18.04.2015 / PubMed / Full text
Functional Effect of Pim1 Depends upon Intracellular Localization in Human Cardiac Progenitor Cells. / 29.05.2015 / PubMed / Full text
MDM2 turnover and expression of ATRX determine the choice between quiescence and senescence in response to CDK4 inhibition. / 10.04.2015 / PubMed / Full text
Evidence for a CDK4-dependent checkpoint in a conditional model of cellular senescence. / 2015 / PubMed / Full text
MiR-506 suppresses proliferation and induces senescence by directly targeting the CDK4/6-FOXM1 axis in ovarian cancer. / 07.2014 / PubMed / Full text

DMDПравить

Aldehyde dehydrogenases contribute to skeletal muscle homeostasis in healthy, aging, and Duchenne muscular dystrophy patients. / 08.2020 / PubMed / Full text
Life expectancy at birth in Duchenne muscular dystrophy: a systematic review and meta-analysis. / 07.2020 / PubMed / Full text
Renal dysfunction can occur in advanced-stage Duchenne muscular dystrophy. / 02.2020 / PubMed / Full text
The long dystrophin gene product Dp427 modulates retinal function and vascular morphology in response to age and retinal ischemia. / 10.2019 / PubMed / Full text
Hemojuvelin is a novel suppressor for Duchenne muscular dystrophy and age-related muscle wasting. / 06.2019 / PubMed / Full text
Age-dependent changes in metabolite profile and lipid saturation in dystrophic mice. / 05.2019 / PubMed / Full text
Muscle function and age are associated with loss of bone mineral density in Duchenne muscular dystrophy. / 04.2019 / PubMed / Full text
Use of bone age for evaluating bone density in patients with Duchenne muscular dystrophy: A preliminary report. / 04.2019 / PubMed / Full text
Age- and Expertise-Related Differences of Sensorimotor Network Dynamics during Force Control. / 15.09.2018 / PubMed / Full text
Mineralocorticoid Receptor Antagonists in Muscular Dystrophy Mice During Aging and Exercise. / 2018 / PubMed / Full text
Calcium current properties in dystrophin-deficient ventricular cardiomyocytes from aged mdx mice. / 01.2018 / PubMed / Full text
Immunoglobulin therapy ameliorates the phenotype and increases lifespan in the severely affected dystrophin-utrophin double knockout mice. / 12.2017 / PubMed / Full text
The experience of parents of adult sons with Duchenne muscular dystrophy regarding their prolonged roles as primary caregivers: a serial qualitative study. / 04.2019 / PubMed / Full text
Spatial and age-related changes in the microstructure of dystrophic and healthy diaphragms. / 2017 / PubMed / Full text
Growing patients with Duchenne muscular dystrophy: longitudinal changes in their dentofacial morphology and orofacial functional capacities. / 06.04.2018 / PubMed / Full text
Impaired regenerative capacity and lower revertant fibre expansion in dystrophin-deficient mdx muscles on DBA/2 background. / 07.12.2016 / PubMed / Full text
Use of the six-minute walk test to characterize golden retriever muscular dystrophy. / 12.2016 / PubMed / Full text
Small Fractions of Muscular Dystrophy Embryonic Stem Cells Yield Severe Cardiac and Skeletal Muscle Defects in Adult Mouse Chimeras. / 03.2017 / PubMed / Full text
Progressive muscle proteome changes in a clinically relevant pig model of Duchenne muscular dystrophy. / 16.09.2016 / PubMed / Full text
Dystrophin-Deficient Cardiomyopathy. / 31.05.2016 / PubMed / Full text
Low Six4 and Six5 gene dosage improves dystrophic phenotype and prolongs life span of mdx mice. / 08.2016 / PubMed / Full text
Molecular circuitry of stem cell fate in skeletal muscle regeneration, ageing and disease. / 05.2016 / PubMed / Full text
Crosstalk between RyR2 oxidation and phosphorylation contributes to cardiac dysfunction in mice with Duchenne muscular dystrophy. / 12.2015 / PubMed / Full text
Gastrocnemius medialis muscle architecture and physiological cross sectional area in adult males with Duchenne muscular dystrophy. / 06.2015 / PubMed / Full text
G-CSF supports long-term muscle regeneration in mouse models of muscular dystrophy. / 13.04.2015 / PubMed / Full text
Lack of dystrophin protein Dp71 results in progressive cataract formation due to loss of fiber cell organization. / 2014 / PubMed / Full text
Age-dependent changes in diastolic Ca(2 ) and Na( ) concentrations in dystrophic cardiomyopathy: Role of Ca(2 ) entry and IP3. / 03.10.2014 / PubMed / Full text
Transitioning to adulthood with a progressive condition: best practice assumptions and individual experiences of young men with Duchenne muscular dystrophy. / 2015 / PubMed / Full text
Discovery of serum protein biomarkers in the mdx mouse model and cross-species comparison to Duchenne muscular dystrophy patients. / 15.12.2014 / PubMed / Full text
Notch signaling deficiency underlies age-dependent depletion of satellite cells in muscular dystrophy. / 08.2014 / PubMed / Full text

FGF23Править

Phosphate as a Pathogen of Arteriosclerosis and Aging. / 08.10.2020 / PubMed / Full text
Plasma Soluble αKlotho, Serum Fibroblast Growth Factor 23, and Mobility Disability in Community-Dwelling Older Adults. / 01.05.2020 / PubMed / Full text
Protective effect of Polygonatum sibiricum Polysaccharide on D-galactose-induced aging rats model. / 10.02.2020 / PubMed / Full text
FGF23 expression is stimulated in transgenic α-Klotho longevity mouse model. / 05.12.2019 / PubMed / Full text
Fibroblast growth factor 23 and symmetric dimethylarginine concentrations in geriatric cats. / 11.2019 / PubMed / Full text
Muscle-bone crosstalk and potential therapies for sarco-osteoporosis. / 09.2019 / PubMed / Full text
Extraskeletal Calcifications in Hutchinson-Gilford Progeria Syndrome. / 08.2019 / PubMed / Full text
Genome-wide associations and detection of potential candidate genes for direct genetic and maternal genetic effects influencing dairy cattle body weight at different ages. / 06.02.2019 / PubMed / Full text
Age-Related Changes and Effects of Bisphosphonates on Bone Turnover and Disease Progression in Fibrous Dysplasia of Bone. / 04.2019 / PubMed / Full text
Kotho and aging. / 09.2016 / PubMed
The Klotho proteins in health and disease. / 01.2019 / PubMed / Full text
Wnt signaling in bone, kidney, intestine, and adipose tissue and interorgan interaction in aging. / 04.2019 / PubMed / Full text
Towards frailty biomarkers: Candidates from genes and pathways regulated in aging and age-related diseases. / 11.2018 / PubMed / Full text
New Insights into the Mechanism of Action of Soluble Klotho. / 2017 / PubMed / Full text
The relevance of α-KLOTHO to the central nervous system: Some key questions. / 07.2017 / PubMed / Full text
Fibroblast Growth Factor 23 and the Risk of Infection-Related Hospitalization in Older Adults. / 04.2017 / PubMed / Full text
Reduction of calprotectin and phosphate during testosterone therapy in aging men: a randomized controlled trial. / 05.2017 / PubMed / Full text
Association between circulating fibroblast growth factor-23 and age-related cardiovascular-renal parameters in a healthy Chinese population. / 08.2017 / PubMed / Full text
The FGF23/KLOTHO Regulatory Network and Its Roles in Human Disorders. / 2016 / PubMed / Full text
Wound healing delays in α-Klotho-deficient mice that have skin appearance similar to that in aged humans - Study of delayed wound healing mechanism. / 13.05.2016 / PubMed / Full text
Partial Reversal of Tissue Calcification and Extension of Life Span following Ammonium Nitrate Treatment of Klotho-Deficient Mice. / 2016 / PubMed / Full text
[Regulatory mechanism of circulating inorganic phosphate]. / 02.2016 / PubMed / Full text
Biological Role of Anti-aging Protein Klotho. / 03.2015 / PubMed / Full text
Soluble αKlotho as a candidate for the biomarker of aging. / 27.11.2015 / PubMed / Full text
Acetazolamide sensitive tissue calcification and aging of klotho-hypomorphic mice. / 01.2016 / PubMed / Full text
N-ethyl-N-Nitrosourea (ENU) induced mutations within the klotho gene lead to ectopic calcification and reduced lifespan in mouse models. / 2015 / PubMed / Full text
Intracellular signaling of the aging suppressor protein Klotho. / 2015 / PubMed / Full text
Tumour-associated osteomalacia and hypoglycaemia in a patient with prostate cancer: is Klotho involved? / 17.11.2014 / PubMed / Full text
Calpain 1 inhibitor BDA-410 ameliorates α-klotho-deficiency phenotypes resembling human aging-related syndromes. / 01.08.2014 / PubMed / Full text
[Bone metabolism and cardiovascular function update. α-klotho/FGF23 system; a new insight into the field of mineral homeostasis and the pathogeneses of aging-associated syndromes and the complications of chronic kidney disease]. / 07.2014 / PubMed / Full text

WRNПравить

The Impact of Vitamin C on Different System Models of Werner Syndrome. / 17.11.2020 / PubMed / Full text
WRN modulates translation by influencing nuclear mRNA export in HeLa cancer cells. / 14.10.2020 / PubMed / Full text
MIB1-mediated degradation of WRN promotes cellular senescence in response to camptothecin treatment. / 09.2020 / PubMed / Full text
A Case Report of Werner's Syndrome With a Novel Mutation From India. / 08.05.2020 / PubMed / Full text
Evidence for premature aging in a Drosophila model of Werner syndrome. / 11.2019 / PubMed / Full text
Epigenetic signatures of Werner syndrome occur early in life and are distinct from normal epigenetic aging processes. / 10.2019 / PubMed / Full text
Studying Werner syndrome to elucidate mechanisms and therapeutics of human aging and age-related diseases. / 06.2019 / PubMed / Full text
Werner Syndrome Protein and DNA Replication. / 02.11.2018 / PubMed / Full text
A case report of Werner's syndrome with bilateral juvenile cataracts. / 14.08.2018 / PubMed / Full text
Genomic instability and DNA replication defects in progeroid syndromes. / 31.12.2018 / PubMed / Full text
Nonfunctional mutant Wrn protein leads to neurological deficits, neuronal stress, microglial alteration, and immune imbalance in a mouse model of Werner syndrome. / 10.2018 / PubMed / Full text
Acidic domain of WRNp is critical for autophagy and up-regulates age associated proteins. / 08.2018 / PubMed / Full text
RECQ helicase disease and related progeroid syndromes: RECQ2018 meeting. / 07.2018 / PubMed / Full text
Differential stem cell aging kinetics in Hutchinson-Gilford progeria syndrome and Werner syndrome. / 04.2018 / PubMed / Full text
Serum vitamin C levels modulate the lifespan and endoplasmic reticulum stress response pathways in mice synthesizing a nonfunctional mutant WRN protein. / 07.2018 / PubMed / Full text
Werner syndrome (WRN) gene variants and their association with altered function and age-associated diseases. / 01.2018 / PubMed / Full text
Human RecQL4 helicase plays multifaceted roles in the genomic stability of normal and cancer cells. / 28.01.2018 / PubMed / Full text
Recent Advances in Understanding Werner Syndrome. / 2017 / PubMed / Full text
Systematic analysis of DNA crosslink repair pathways during development and aging in Caenorhabditis elegans. / 19.09.2017 / PubMed / Full text
The Werner Syndrome Helicase Coordinates Sequential Strand Displacement and FEN1-Mediated Flap Cleavage during Polymerase δ Elongation. / 01.02.2017 / PubMed / Full text
Vitamin C alleviates aging defects in a stem cell model for Werner syndrome. / 07.2016 / PubMed / Full text
Bloom's syndrome: Why not premature aging?: A comparison of the BLM and WRN helicases. / 01.2017 / PubMed / Full text
Understanding Vascular Diseases: Lessons From Premature Aging Syndromes. / 05.2016 / PubMed / Full text
Stem Cell Depletion by Global Disorganization of the H3K9me3 Epigenetic Marker in Aging. / 08.2015 / PubMed / Full text
The Werner Protein Acts as a Coactivator of Nuclear Factor κB (NF-κB) on HIV-1 and Interleukin-8 (IL-8) Promoters. / 24.07.2015 / PubMed / Full text
Aging stem cells. A Werner syndrome stem cell model unveils heterochromatin alterations as a driver of human aging. / 05.06.2015 / PubMed / Full text
Werner Syndrome-specific induced pluripotent stem cells: recovery of telomere function by reprogramming. / 2015 / PubMed / Full text
Transient overexpression of Werner protein rescues starvation induced autophagy in Werner syndrome cells. / 12.2014 / PubMed / Full text
Senescence induced by RECQL4 dysfunction contributes to Rothmund-Thomson syndrome features in mice. / 15.05.2014 / PubMed / Full text
Search and insights into novel genetic alterations leading to classical and atypical Werner syndrome. / 2014 / PubMed / Full text