Aging genes 10-29

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Probing menstrual bloodstain aging with fluorescence spectroscopy. / 13.11.2020 / PubMed / Full text
Effect of physical exercise and medication on enhancing cognitive function in older adults with vascular risk. / 11.2020 / PubMed / Full text
A novel indenone derivative selectively induces senescence in MDA-MB-231 (breast adenocarcinoma) cells. / 01.11.2020 / PubMed / Full text
Improved Autophagic Flux in Escapers from Doxorubicin-Induced Senescence/Polyploidy of Breast Cancer Cells. / 24.08.2020 / PubMed / Full text
Lifespan regulation in α/β posterior neurons of the fly mushroom bodies by Rab27. / 08.2020 / PubMed / Full text
Tailored Functionalized Magnetic Nanoparticles to Target Breast Cancer Cells Including Cancer Stem-Like Cells. / 29.05.2020 / PubMed / Full text
"Mitotic Slippage" and Extranuclear DNA in Cancer Chemoresistance: A Focus on Telomeres. / 16.04.2020 / PubMed / Full text
Diversity of the Senescence Phenotype of Cancer Cells Treated with Chemotherapeutic Agents. / 23.11.2019 / PubMed / Full text
Downregulation of the inflammatory network in senescent fibroblasts and aging tissues of the long-lived and cancer-resistant subterranean wild rodent, Spalax. / 01.2020 / PubMed / Full text
Quantification of the health-status of the Dutch Labrador retriever population. / 01.11.2019 / PubMed / Full text
Conjugated Physiological Resveratrol Metabolites Induce Senescence in Breast Cancer Cells: Role of p53/p21 and p16/Rb Pathways, and ABC Transporters. / 11.2019 / PubMed / Full text
Reducing interruptions during medication preparation and administration. / 08.07.2019 / PubMed / Full text
Different sensitivities of senescent breast cancer cells to immune cell-mediated cytotoxicity. / 09.2019 / PubMed / Full text
Immobilization of rubber additive on graphene for high-performance rubber composites. / 15.08.2019 / PubMed / Full text
Short and Long-Term Effects of the Exposure of Breast Cancer Cell Lines to Different Ratios of Free or Co-Encapsulated Liposomal Paclitaxel and Doxorubicin. / 11.04.2019 / PubMed / Full text
Individual components of the SWI/SNF chromatin remodelling complex have distinct roles in memory neurons of the [i]Drosophila[/i] mushroom body. / 25.03.2019 / PubMed / Full text
Ginsenoside Rh2 Ameliorates Doxorubicin-Induced Senescence Bystander Effect in Breast Carcinoma Cell MDA-MB-231 and Normal Epithelial Cell MCF-10A. / 12.03.2019 / PubMed / Full text
Age-related histomorphometric and immunohistochemical changes of the moderator band in Egyptian Baladi cattle. / 03.2019 / PubMed / Full text
Dynamic Metabolic Response to Adriamycin-Induced Senescence in Breast Cancer Cells. / 15.12.2018 / PubMed / Full text
Elastin molecular aging promotes MDA-MB-231 breast cancer cell invasiveness. / 09.2018 / PubMed / Full text
Antitumor activity of NAX060: A novel semisynthetic berberine derivative in breast cancer cells. / 09.2018 / PubMed / Full text
Effects of carnitine palmitoyltransferases on cancer cellular senescence. / 02.2019 / PubMed / Full text
A miRNAs profile evolution of triple negative breast cancer cells in the presence of a possible adjuvant therapy and senescence inducer. / 05-06.2018 / PubMed
Resveratrol promotes oxidative stress to drive DLC1 mediated cellular senescence in cancer cells. / 15.09.2018 / PubMed / Full text
Conditioned medium from stimulated macrophages inhibits growth but induces an inflammatory phenotype in breast cancer cells. / 10.2018 / PubMed / Full text
TASK-3 Downregulation Triggers Cellular Senescence and Growth Inhibition in Breast Cancer Cell Lines. / 29.03.2018 / PubMed / Full text
Autophagic cell death and premature senescence: New mechanism of 5-fluorouracil and sulforaphane synergistic anticancer effect in MDA-MB-231 triple negative breast cancer cell line. / 01.2018 / PubMed / Full text
Influence of DARPP-32 genetic variation on BOLD activation to happy faces. / 01.10.2017 / PubMed / Full text
Age-related remodeling of the JAK/STAT/SOCS signaling pathway and associated myocardial changes: From histological to molecular level. / 11.2017 / PubMed / Full text

TLR4

Age-Dependent Changes of Adipokine and Cytokine Secretion From Rat Adipose Tissue by Endogenous and Exogenous Toll-Like Receptor Agonists. / 2020 / PubMed / Full text
Role of Toll Like Receptor 4 in Alzheimer's Disease. / 2020 / PubMed / Full text
Commentary on Some Recent Theses Relevant to Combating Aging: August 2020. / 08.2020 / PubMed / Full text
Sialylation and Galectin-3 in Microglia-Mediated Neuroinflammation and Neurodegeneration. / 2020 / PubMed / Full text
Chemerin facilitates intervertebral disc degeneration via TLR4 and CMKLR1 and activation of NF-kB signaling pathway. / 11.06.2020 / PubMed / Full text
Toll-like receptor 4 differentially regulates adult hippocampal neurogenesis in an age- and sex-dependent manner. / 09.2020 / PubMed / Full text
Aging-associated immunosenescence via alterations in splenic immune cell populations in rat. / 15.01.2020 / PubMed / Full text
Leptin induces immunosenescence in human B cells. / 02.2020 / PubMed / Full text
Genetic Variation in the Magnitude and Longevity of the IgG Subclass Response to a Diphtheria-Tetanus-Acellular Pertussis (DTaP) Vaccine in Mice. / 20.09.2019 / PubMed / Full text
Rapamycin improves sevoflurane‑induced cognitive dysfunction in aged rats by mediating autophagy through the TLR4/MyD88/NF‑κB signaling pathway. / 10.2019 / PubMed / Full text
Targeting HMGB1 by ethyl pyruvate ameliorates systemic lupus erythematosus and reverses the senescent phenotype of bone marrow-mesenchymal stem cells. / 14.07.2019 / PubMed / Full text
Age-dependent effect between MARCO and TLR4 on PMMA particle phagocytosis by macrophages. / 08.2019 / PubMed / Full text
Regulation of Toll-Like Receptor (TLR) Signaling Pathway by Polyphenols in the Treatment of Age-Linked Neurodegenerative Diseases: Focus on TLR4 Signaling. / 2019 / PubMed / Full text
TLR4 Promotes and DAP12 Limits Obesity-Induced Osteoarthritis in Aged Female Mice. / 04.2019 / PubMed / Full text
Novel Chitohexaose Analog Protects Young and Aged mice from CLP Induced Polymicrobial Sepsis. / 27.02.2019 / PubMed / Full text
Endothelial toll-like receptor 4 maintains lung integrity via epigenetic suppression of p16 . / 06.2019 / PubMed / Full text
Budesonide, Aclidinium and Formoterol in combination limit inflammaging processes in bronchial epithelial cells exposed to cigarette smoke. / 04.2019 / PubMed / Full text
Aging leads to dysfunctional innate immune responses to TLR2 and TLR4 agonists. / 09.2019 / PubMed / Full text
Plasmalogens Inhibit Endocytosis of Toll-like Receptor 4 to Attenuate the Inflammatory Signal in Microglial Cells. / 05.2019 / PubMed / Full text
Ablation of toll-like receptor 4 attenuates aging-induced myocardial remodeling and contractile dysfunction through NCoRI-HDAC1-mediated regulation of autophagy. / 06.2018 / PubMed / Full text
Cryopreserved whole blood for the quantification of monocyte, T-cell and NK-cell subsets, and monocyte receptor expression by multi-color flow cytometry: A methodological study based on participants from the canadian longitudinal study on aging. / 05.2018 / PubMed / Full text
Inflammation, insulin signaling and cognitive function in aged APP/PS1 mice. / 05.2018 / PubMed / Full text
Repeated stimulation by LPS promotes the senescence of DPSCs via TLR4/MyD88-NF-κB-p53/p21 signaling. / 06.2018 / PubMed / Full text
Ageing potentiates diet-induced glucose intolerance, β-cell failure and tissue inflammation through TLR4. / 09.02.2018 / PubMed / Full text
Fibronectin Containing Extra Domain A Induces Plaque Destabilization in the Innominate Artery of Aged Apolipoprotein E-Deficient Mice. / 03.2018 / PubMed / Full text
Granzyme A in Human Platelets Regulates the Synthesis of Proinflammatory Cytokines by Monocytes in Aging. / 01.01.2018 / PubMed / Full text
TLR4 and TLR2 activation is differentially associated with age during Parkinson's disease. / 01.2018 / PubMed / Full text
Toll-like receptor 4 (TLR4) deficient mice are protected from adipose tissue inflammation in aging. / 07.09.2017 / PubMed / Full text
Role of pattern recognition receptors of the neurovascular unit in inflamm-aging. / 01.11.2017 / PubMed / Full text

GDF11

Growth differentiation factor-11 supplementation improves survival and promotes recovery after ischemic stroke in aged mice. / 04.05.2020 / PubMed / Full text
Anti-Aging Effects of GDF11 on Skin. / 09.04.2020 / PubMed / Full text
Targeted Approach to Distinguish and Determine Absolute Levels of GDF8 and GDF11 in Mouse Serum. / 06.2020 / PubMed / Full text
Growth differentiation factor 11 impairs titanium implant healing in the femur and leads to mandibular bone loss. / 09.2020 / PubMed / Full text
Systemic GDF11 stimulates the secretion of adiponectin and induces a calorie restriction-like phenotype in aged mice. / 01.2020 / PubMed / Full text
Circulating factors in young blood as potential therapeutic agents for age-related neurodegenerative and neurovascular diseases. / 11.2019 / PubMed / Full text
Effects of Exercise Training on Growth and Differentiation Factor 11 Expression in Aged Mice. / 2019 / PubMed / Full text
TERT assists GDF11 to rejuvenate senescent VEGFR2 /CD133 cells in elderly patients with myocardial infarction. / 11.2019 / PubMed / Full text
The role of GDF11 in aging and skeletal muscle, cardiac and bone homeostasis. / 04.2019 / PubMed / Full text
Circulating GDF11 levels are decreased with age but are unchanged with obesity and type 2 diabetes. / 21.03.2019 / PubMed / Full text
Activin type II receptor signaling in cardiac aging and heart failure. / 06.03.2019 / PubMed / Full text
Neuroprotective potential of GDF11 in experimental intracerebral hemorrhage in elderly rats. / 05.2019 / PubMed / Full text
The influence of GDF11 on brain fate and function. / 02.2019 / PubMed / Full text
Administration of rGDF11 retards the aging process in male mice via action of anti-oxidant system. / 08.2019 / PubMed / Full text
Novel biomolecules of ageing, sex differences and potential underlying mechanisms of telomere shortening in coronary artery disease. / 05.2019 / PubMed / Full text
The Growth Differentiation Factor 11 is Involved in Skin Fibroblast Ageing and is Induced by a Preparation of Peptides and Sugars Derived from Plant Cell Cultures. / 03.2019 / PubMed / Full text
[The role of «Youth and aging proteins» in essential hypertension pathogenesis.] / 2018 / PubMed
Regenerative Capacity of Endogenous Factor: Growth Differentiation Factor 11; a New Approach of the Management of Age-Related Cardiovascular Events. / 12.12.2018 / PubMed / Full text
Late-onset administration of GDF11 extends life span and delays development of age-related markers in the annual fish Nothobranchius guentheri. / 04.2019 / PubMed / Full text
Growth Differentiation Factor 11 treatment leads to neuronal and vascular improvements in the hippocampus of aged mice. / 23.11.2018 / PubMed / Full text
Relationship of Circulating Growth and Differentiation Factors 8 and 11 and Their Antagonists as Measured Using Liquid Chromatography-Tandem Mass Spectrometry With Age and Skeletal Muscle Strength in Healthy Adults. / 01.01.2019 / PubMed / Full text
The GDF11-FTO-PPARγ axis controls the shift of osteoporotic MSC fate to adipocyte and inhibits bone formation during osteoporosis. / 12.2018 / PubMed / Full text
The effects of aging, diabetes mellitus, and antiplatelet drugs on growth factors and anti-aging proteins in platelet-rich plasma. / 2019 / PubMed / Full text
Relationship of muscle function to circulating myostatin, follistatin and GDF11 in older women and men. / 30.08.2018 / PubMed / Full text
Activin subfamily peptides predict chronological age in humans. / 09.2018 / PubMed / Full text
Growth differentiation factor 11 worsens hepatocellular injury and liver regeneration after liver ischemia reperfusion injury. / 09.2018 / PubMed / Full text
The [i]Drosophila[/i] TGF-beta/Activin-like ligands Dawdle and Myoglianin appear to modulate adult lifespan through regulation of 26S proteasome function in adult muscle. / 26.04.2018 / PubMed / Full text

SIRT6

Association between SIRT6 Methylation and Human Longevity in a Chinese Population. / 25.11.2020 / PubMed / Full text
The SIRT6 activator MDL-800 improves genomic stability and pluripotency of old murine-derived iPS cells. / 08.2020 / PubMed / Full text
Sirtuins as Possible Predictors of Aging and Alzheimer's Disease Development: Verification in the Hippocampus and Saliva. / 10.2020 / PubMed / Full text
Age-related epigenetic drift deregulates [i]SIRT6[/i] expression and affects its downstream genes in human peripheral blood mononuclear cells. / 12.2020 / PubMed / Full text
Biological and catalytic functions of sirtuin 6 as targets for small-molecule modulators. / 07.08.2020 / PubMed / Full text
Age-dependent role of SIRT6 in jawbone via regulating senescence and autophagy of bone marrow stromal cells. / 02.2020 / PubMed / Full text
Mechanism of activation for the sirtuin 6 protein deacylase. / 31.01.2020 / PubMed / Full text
Proteomics of Long-Lived Mammals. / 03.2020 / PubMed / Full text
Sirtuins and SIRT6 in Carcinogenesis and in Diet. / 07.10.2019 / PubMed / Full text
SIRT6-mediated transcriptional suppression of MALAT1 is a key mechanism for endothelial to mesenchymal transition. / 15.11.2019 / PubMed / Full text
SIRT6 Is Responsible for More Efficient DNA Double-Strand Break Repair in Long-Lived Species. / 18.04.2019 / PubMed / Full text
SIRT6 participates in the quality control of aged oocytes via modulating telomere function. / 29.03.2019 / PubMed / Full text
LINE1 Derepression in Aged Wild-Type and SIRT6-Deficient Mice Drives Inflammation. / 02.04.2019 / PubMed / Full text
Relationship between senescence in macaques and bone marrow mesenchymal stem cells and the molecular mechanism. / 23.01.2019 / PubMed / Full text
Diesel exhaust exposure intensifies inflammatory and structural changes associated with lung aging in mice. / 15.04.2019 / PubMed / Full text
Phosphodiesterase 4 inhibitor activates AMPK-SIRT6 pathway to prevent aging-related adipose deposition induced by metabolic disorder. / 18.09.2018 / PubMed / Full text
MiR-125b attenuates human hepatocellular carcinoma malignancy through targeting SIRT6. / 2018 / PubMed / Full text
Role of accelerated aging in limb muscle wasting of patients with COPD. / 2018 / PubMed / Full text
A Review of the Recent Advances Made with SIRT6 and its Implications on Aging Related Processes, Major Human Diseases, and Possible Therapeutic Targets. / 29.06.2018 / PubMed / Full text
Application of multivariate longitudinal models in SIRT6, FBS, and BMI analysis of the elderly. / 12.2019 / PubMed / Full text
Sirtuins in Renal Health and Disease. / 07.2018 / PubMed / Full text
Boosting ATM activity alleviates aging and extends lifespan in a mouse model of progeria. / 02.05.2018 / PubMed / Full text
High expression of CPT1b in skeletal muscle in metabolically healthy older subjects. / 04.2019 / PubMed / Full text
Haploinsufficiency of [i]Trp53[/i] dramatically extends the lifespan of Sirt6-deficient mice. / 23.02.2018 / PubMed / Full text
SIRT6 histone deacetylase functions as a potential oncogene in human melanoma. / 09.2017 / PubMed / Full text
Stem Cells and Progenitors in Human Peripheral Blood Get Activated by Extremely Active Resveratrol (XAR™). / 04.2018 / PubMed / Full text
Aging as an Epigenetic Phenomenon. / 10.2017 / PubMed / Full text

H2AX

Evaluation of GammaH2AX in Buccal Cells as a Molecular Biomarker of DNA Damage in Alzheimer's Disease in the AIBL Study of Ageing. / 06.08.2020 / PubMed / Full text
Cisplatin-induced peripheral neuropathy is associated to neuronal senescence-like response. / 29.06.2020 / PubMed / Full text
Guanine Deaminase Stimulates Ultraviolet-induced Keratinocyte Senescence in Seborrhoeic Keratosis via Guanine Metabolites. / 06.04.2020 / PubMed / Full text
Do BRCA1 and BRCA2 gene mutation carriers have a reduced ovarian reserve? Protocol for a prospective observational study. / 25.11.2019 / PubMed / Full text
Slower rates of accumulation of DNA damage in leukocytes correlate with longer lifespans across several species of birds and mammals. / 15.11.2019 / PubMed / Full text
Phosphoproteomic analysis reveals plant DNA damage signalling pathways with a functional role for histone H2AX phosphorylation in plant growth under genotoxic stress. / 12.2019 / PubMed / Full text
Rag1 immunodeficiency-induced early aging and senescence in zebrafish are dependent on chronic inflammation and oxidative stress. / 10.2019 / PubMed / Full text
Are There Common Mechanisms Between the Hutchinson-Gilford Progeria Syndrome and Natural Aging? / 2019 / PubMed / Full text
Epigallocatechin-3-gallate induces telomere shortening and clastogenic damage in glioblastoma cells. / 10.2019 / PubMed / Full text
Expression of RNF8 on cochlear apoptosis and aging in mice of different ages. / 03-Apr,.2019 / PubMed
Mitochondrial Protection Partly Mitigates Kidney Cellular Senescence in Swine Atherosclerotic Renal Artery Stenosis. / 2019 / PubMed / Full text
Old age increases microglial senescence, exacerbates secondary neuroinflammation, and worsens neurological outcomes after acute traumatic brain injury in mice. / 05.2019 / PubMed / Full text
Avenanthramide A Induces Cellular Senescence via miR-129-3p/Pirh2/p53 Signaling Pathway To Suppress Colon Cancer Growth. / 01.05.2019 / PubMed / Full text
PFG acted as an inducer of premature senescence in TIG-1 normal diploid fibroblast and an inhibitor of mitosis in the HeLa cells. / 06.2019 / PubMed / Full text
S100A13 promotes senescence-associated secretory phenotype and cellular senescence via modulation of non-classical secretion of IL-1α. / 23.01.2019 / PubMed / Full text
Clostridium difficile toxin B induces senescence in enteric glial cells: A potential new mechanism of Clostridium difficile pathogenesis. / 12.2018 / PubMed / Full text
Varenicline reduces DNA damage, tau mislocalization and post surgical cognitive impairment in aged mice. / 12.2018 / PubMed / Full text
The activated DNA double-strand break repair pathway in cumulus cells from aging patients may be used as a convincing predictor of poor outcomes after in vitro fertilization-embryo transfer treatment. / 2018 / PubMed / Full text
Micro-RNAS Regulate Metabolic Syndrome-induced Senescence in Porcine Adipose Tissue-derived Mesenchymal Stem Cells through the P16/MAPK Pathway. / 10.2018 / PubMed / Full text
Acetylation of PGC1α by Histone Deacetylase 1 Downregulation Is Implicated in Radiation-Induced Senescence of Brain Endothelial Cells. / 16.05.2019 / PubMed / Full text
Role of accelerated aging in limb muscle wasting of patients with COPD. / 2018 / PubMed / Full text
[Protective effect of Wuzi Yanzong recipe on testicular DNA damage and apoptosis in natural ageing rats]. / 04.2018 / PubMed / Full text
Replication Stress Shapes a Protective Chromatin Environment across Fragile Genomic Regions. / 04.01.2018 / PubMed / Full text
Thioredoxin mitigates radiation-induced hematopoietic stem cell injury in mice. / 15.11.2017 / PubMed / Full text
Therapeutic doses of doxorubicin induce premature senescence of human mesenchymal stem cells derived from menstrual blood, bone marrow and adipose tissue. / 03.2018 / PubMed / Full text
Hydrogen-rich pure water prevents cigarette smoke-induced pulmonary emphysema in SMP30 knockout mice. / 07.10.2017 / PubMed / Full text

TF

A preliminary investigation of the contribution of different tenderness factors to beef loin, tri-tip and heel tenderness. / 12.2020 / PubMed / Full text
The transcription factor ZmNAC126 accelerates leaf senescence downstream of the ethylene signalling pathway in maize. / 09.2020 / PubMed / Full text
Extensive transcriptome changes during seasonal leaf senescence in field-grown black cottonwood (Populus trichocarpa Nisqually-1). / 20.04.2020 / PubMed / Full text
Expression of Transferrin and Albumin in the Sperm-Storage Tubules of Japanese Quail and their Possible Involvement in Long-Term Sperm Storage. / 25.01.2020 / PubMed / Full text
OsWRKY5 Promotes Rice Leaf Senescence via Senescence-Associated NAC and Abscisic Acid Biosynthesis Pathway. / 09.09.2019 / PubMed / Full text
BrTCP7 Transcription Factor Is Associated with MeJA-Promoted Leaf Senescence by Activating the Expression of [i]BrOPR3[/i] and [i]BrRCCR[/i]. / 14.08.2019 / PubMed / Full text
Activation of the Transcription of [i]BrGA20ox3[/i] by a BrTCP21 Transcription Factor Is Associated with Gibberellin-Delayed Leaf Senescence in Chinese Flowering Cabbage during Storage. / 08.08.2019 / PubMed / Full text
Anti-aging effects of long-term space missions, estimated by heart rate variability. / 20.06.2019 / PubMed / Full text
Transgenic expression of rice MYB102 (OsMYB102) delays leaf senescence and decreases abiotic stress tolerance in Arabidopsis thaliana. / 11.2019 / PubMed / Full text
Tomato fruit ripening factor NOR controls leaf senescence. / 09.05.2019 / PubMed / Full text
The WRKY transcription factor GhWRKY27 coordinates the senescence regulatory pathway in upland cotton (Gossypium hirsutum L.). / 29.03.2019 / PubMed / Full text
Effects of cerium oxide nanoparticles on hemostasis: Coagulation, platelets, and vascular endothelial cells. / 07.2019 / PubMed / Full text
Rice transcription factor OsMYB102 delays leaf senescence by down-regulating abscisic acid accumulation and signaling. / 09.05.2019 / PubMed / Full text
Identification of key genes and transcription factors in aging mesenchymal stem cells by DNA microarray data. / 15.04.2019 / PubMed / Full text
Bioinformatic Analysis Reveals Key Genes and Pathways in Aging Brain of Senescence-accelerated Mouse P8 (SAMP8). / 2018 / PubMed / Full text
Cardiac regenerative capacity is age- and disease-dependent in childhood heart disease. / 2018 / PubMed / Full text
Comparing palm oil tocotrienol rich fraction with α-tocopherol supplementation on oxidative stress in healthy older adults. / 10.2017 / PubMed / Full text
The endothelial tumor suppressor p53 is essential for venous thrombus formation in aged mice. / 12.06.2018 / PubMed / Full text
Comparing Palm Oil, Tocotrienol-Rich Fraction and α-Tocopherol Supplementation on the Antioxidant Levels of Older Adults. / 28.05.2018 / PubMed / Full text
Improved synaptic and cognitive function in aged 3 × Tg-AD mice with reduced amyloid-β after immunotherapy with a novel recombinant 6Aβ15-TF chimeric vaccine. / 08.2018 / PubMed / Full text
Zbtb20 Regulates Developmental Neurogenesis in the Olfactory Bulb and Gliogenesis After Adult Brain Injury. / 01.2019 / PubMed / Full text
Molecular and functional characterization of ShNAC1, an NAC transcription factor from Solanum habrochaites. / 06.2018 / PubMed / Full text
Characterization of a Transcriptional Regulator, BrWRKY6, Associated with Gibberellin-Suppressed Leaf Senescence of Chinese Flowering Cabbage. / 28.02.2018 / PubMed / Full text
Global mapping of transcription factor motifs in human aging. / 2018 / PubMed / Full text
MicroRNAs Regulate Thymic Epithelium in Age-Related Thymic Involution via Down- or Upregulation of Transcription Factors. / 2017 / PubMed / Full text
Cell reprogramming: Therapeutic potential and the promise of rejuvenation for the aging brain. / 11.2017 / PubMed / Full text

C3

Inverse association between periumbilical fat and longevity mediated by complement C3 and cardiac structure. / 18.11.2020 / PubMed / Full text
Complement C3 deficiency ameliorates aging related changes in the kidney. / 01.11.2020 / PubMed / Full text
Reduced sialylation triggers homeostatic synapse and neuronal loss in middle-aged mice. / 04.2020 / PubMed / Full text
[Comparative analysis of experimental data about the effects of various polyphenols on lifespan and aging.] / 2019 / PubMed
Age-Associated Dopaminergic Neuron Loss and Midbrain Glia Cell Phenotypic Polarization. / 01.09.2019 / PubMed / Full text
Individual and combined effects of salinity and lipopolysaccharides on the immune response of juvenile Takifugu fasciatus. / 06.2019 / PubMed / Full text
[Young and old animals use different strategies for forming an immune response to infectious agents (Pseudomonas aeruginosa и Escherichia coli).] / 2018 / PubMed
TREM2 triggers microglial density and age-related neuronal loss. / 03.2019 / PubMed / Full text
Age and Sex-Associated Changes of Complement Activity and Complement Levels in a Healthy Caucasian Population. / 2018 / PubMed / Full text
Traumatic Brain Injury in Aged Mice Induces Chronic Microglia Activation, Synapse Loss, and Complement-Dependent Memory Deficits. / 26.11.2018 / PubMed / Full text
Dialdehyde cellulose crosslinked poly(vinyl alcohol) hydrogels: Influence of catalyst and crosslinker shelf life. / 15.10.2018 / PubMed / Full text
Effects of Feeding Honey Bees (Hymenoptera: Apidae) With Industrial Sugars Produced by Plants Using Different Photosynthetic Cycles (Carbon C3 and C4) on the Colony Wintering Ability, Lifespan, and Forage Behavior. / 26.09.2018 / PubMed / Full text
The expression of C1 inhibitor (C1INH) in macrophages is upregulated by retinal pigment epithelial cells - implication in subretinal immune privilege in the aging eye. / 13.06.2018 / PubMed / Full text
Human Cord Blood Serum-Derived APP α-Secretase Cleavage Activity is Mediated by C1 Complement. / 04.2018 / PubMed / Full text
Altered gene expression pattern indicates the differential regulation of the immune response system as an important factor in cardiac aging. / 03.2019 / PubMed / Full text
Age-related collagen turnover of the interstitial matrix and basement membrane: Implications of age- and sex-dependent remodeling of the extracellular matrix. / 2018 / PubMed / Full text
Aging-related tau astrogliopathy (ARTAG): not only tau phosphorylation in astrocytes. / 11.2018 / PubMed / Full text
A potent tilapia secreted granulin peptide enhances the survival of transgenic zebrafish infected by Vibrio vulnificus via modulation of innate immunity. / 04.2018 / PubMed / Full text
Computerized Cognitive Testing for Use in Clinical Trials: A Comparison of the NIH Toolbox and Cogstate C3 Batteries. / 2017 / PubMed / Full text
Antibodies to Senescent Antigen and C3 Are Not Required for Normal Red Blood Cell Lifespan in a Murine Model. / 2017 / PubMed / Full text
Gut dysbiosis breaks immunological tolerance toward the central nervous system during young adulthood. / 31.10.2017 / PubMed / Full text
Some immunological responses of common carp (Cyprinus carpio) fingerling to acute extremely low-frequency electromagnetic fields (50 Hz). / 02.2018 / PubMed / Full text
Metabolomics of laminae and midvein during leaf senescence and source-sink metabolite management in Brassica napus L. leaves. / 12.02.2018 / PubMed / Full text
d-Allulose, a stereoisomer of d-fructose, extends Caenorhabditis elegans lifespan through a dietary restriction mechanism: A new candidate dietary restriction mimetic. / 02.12.2017 / PubMed / Full text
Depletion of the Third Complement Component Ameliorates Age-Dependent Oxidative Stress and Positively Modulates Autophagic Activity in Aged Retinas in a Mouse Model. / 2017 / PubMed / Full text

CCK

Senolytic agent Quercetin ameliorates intervertebral disc degeneration via the Nrf2/NF-κB axis. / 23.11.2020 / PubMed / Full text
Astragalus improve aging bone marrow mesenchymal stem cells (BMSCs) vitality and osteogenesis through VD-FGF23-Klotho axis. / 2020 / PubMed / Full text
Effects of Age on Acute Appetite-Related Responses to Whey-Protein Drinks, Including Energy Intake, Gastric Emptying, Blood Glucose, and Plasma Gut Hormone Concentrations-A Randomized Controlled Trial. / 06.04.2020 / PubMed / Full text
Lactose induced redox-dependent senescence and activated Nrf2 pathway. / 2019 / PubMed / Full text
Quercetin Suppresses the Progression of Atherosclerosis by Regulating MST1-Mediated Autophagy in ox-LDL-Induced RAW264.7 Macrophage Foam Cells. / 03.12.2019 / PubMed / Full text
LncRNA AW112010 Promotes Mitochondrial Biogenesis and Hair Cell Survival: Implications for Age-Related Hearing Loss. / 2019 / PubMed / Full text
Effects of age on feeding response: Focus on the rostral C1 neuron and its glucoregulatory proteins. / 01.2020 / PubMed / Full text
Ser-Tyr and Asn-Ala, vasorelaxing dipeptides found by comprehensive screening, reduce blood pressure via different age-dependent mechanisms. / 04.11.2019 / PubMed / Full text
Fisetin, via CKIP-1/REGγ, limits oxidized LDL-induced lipid accumulation and senescence in RAW264.7 macrophage-derived foam cells. / 15.12.2019 / PubMed / Full text
[Ginsenoside Rg_1 induces leukemia stem cell senescence via SIRT1/TSC_2 signal axis]. / 06.2019 / PubMed / Full text
Chromatin remodeling factor BAZ1A regulates cellular senescence in both cancer and normal cells. / 15.07.2019 / PubMed / Full text
Circular RNA expression profile in human fibroblast premature senescence after repeated ultraviolet B irradiations revealed by microarray. / 08.2019 / PubMed / Full text
Long non-coding RNA-OIS1 inhibits HPV-positive, but not HPV-negative cervical squamous cell carcinoma by upregulating MTK-1. / 03.2019 / PubMed / Full text
Ubiquinol-cytochrome C reductase core protein II promotes tumorigenesis by facilitating p53 degradation. / 02.2019 / PubMed / Full text
MiR-34a Enhances Chondrocyte Apoptosis, Senescence and Facilitates Development of Osteoarthritis by Targeting DLL1 and Regulating PI3K/AKT Pathway. / 2018 / PubMed / Full text
Inhibition of glioma growth by flavokawain B is mediated through endoplasmic reticulum stress induced autophagy. / 2018 / PubMed / Full text
Apelin/APJ axis improves angiotensin II-induced endothelial cell senescence through AMPK/SIRT1 signaling pathway. / 06.2018 / PubMed / Full text
Osthole Delays Tert-Butyl Hydroperoxide-Induced Premature Senescence in Neural Stem Cells. / 08.2018 / PubMed / Full text
N-Cadherin Attenuates High Glucose-Induced Nucleus Pulposus Cell Senescence Through Regulation of the ROS/NF-κB Pathway. / 2018 / PubMed / Full text
Localization of cholecystokinin in the zebrafish retina from larval to adult stage. / 07.2018 / PubMed / Full text
Glutamate-dependent regulation of food intake is altered with age through changes in NMDA receptor phenotypes on vagal afferent neurons. / 15.05.2018 / PubMed / Full text
Effects of Substitution, and Adding of Carbohydrate and Fat to Whey-Protein on Energy Intake, Appetite, Gastric Emptying, Glucose, Insulin, Ghrelin, CCK and GLP-1 in Healthy Older Men-A Randomized Controlled Trial. / 23.01.2018 / PubMed / Full text
Effect of Age on Blood Glucose and Plasma Insulin, Glucagon, Ghrelin, CCK, GIP, and GLP-1 Responses to Whey Protein Ingestion. / 21.12.2017 / PubMed / Full text
Triptolide Promotes Senescence of Prostate Cancer Cells Through Histone Methylation and Heterochromatin Formation / 27.09.2017 / PubMed / Full text
[Effects of ginseng, notoginseng, and Chuanxiong Rhizoma extracts on cytoskeleton protein of replicative senescence vascular smooth muscle cells]. / 02.2016 / PubMed / Full text

DBP

Do baseline blood pressure and type of exercise influence level of reduction induced by training in hypertensive older adults? A meta-analysis of controlled trials. / 15.10.2020 / PubMed / Full text
Attenuated aortic blood pressure responses to metaboreflex activation in older adults with dynapenia. / 09.2020 / PubMed / Full text
The Effect of Blood Pressure on Cognitive Performance. An 8-Year Follow-Up of the Tromsø Study, Comprising People Aged 45-74 Years. / 2020 / PubMed / Full text
Low Diastolic Blood Pressure and Cognitive Decline in Korean Elderly People: The Korean Longitudinal Study on Cognitive Aging and Dementia. / 01.2020 / PubMed / Full text
Diastolic Blood Pressure Is Associated With Regional White Matter Lesion Load: The Northern Manhattan Study. / 02.2020 / PubMed / Full text
Orthostatic Hypotension and Novel Blood Pressure Associated Gene Variants in Older Adults: Data From the TILDA Study. / 15.10.2020 / PubMed / Full text
Blood pressure and hypertension prevalence among oldest-old in China for 16 year: based on CLHLS. / 09.09.2019 / PubMed / Full text
The age-related blood pressure trajectories from young-old adults to centenarians: A cohort study. / 01.12.2019 / PubMed / Full text
Evidence of neurodegeneration in individuals with only mildly elevated blood pressure. / 12.2019 / PubMed / Full text
Upward resetting of the vascular sympathetic baroreflex in middle-aged male runners. / 01.07.2019 / PubMed / Full text
Fruit, vegetable intake and blood pressure trajectories in older age. / 09.2019 / PubMed / Full text
Associations between vitamin D deficiency, musculoskeletal health, and cardiometabolic risk among community-living people in Taiwan: Age and sex-specific relationship. / 12.2018 / PubMed / Full text
Age-differential association between serum uric acid and incident hypertension. / 03.2019 / PubMed / Full text
Effect of phthalates on development, reproduction, fat metabolism and lifespan in Daphnia magna. / 01.03.2019 / PubMed / Full text
The association between urinary sodium excretion and blood pressure in a community-based population: the Yamagata (Takahata) study. / 03.2019 / PubMed / Full text
Differential Associations of Diastolic and Systolic Pressures With Cerebral Measures in Older Individuals With Mild Cognitive Impairment. / 13.11.2018 / PubMed / Full text
Age-related change in thyroid-stimulating hormone: a cross-sectional study in healthy euthyroid population. / 29.11.2018 / PubMed / Full text
[Association between blood pressure related dietary patterns and identified cognitive performance in the elderly Chinese-a study by reduced rank regression method]. / 10.06.2018 / PubMed / Full text
Optimal Blood Pressure in Elderly Hypertensive Subjects: A Korean National Health Insurance Service Health Examinee Cohort Study. / 03.08.2018 / PubMed / Full text
Inter-relationship between ageing, body mass index, diabetes, systemic blood pressure and intraocular pressure in Asians: 6-year longitudinal study. / 02.2019 / PubMed / Full text
Insulin-like factor-2 receptor rs9456497 G genotype overrepresents in males of average population and its correlation with cardiovascular risks. / 05-06.2018 / PubMed / Full text
Association of regular walking and body mass index on metabolic syndrome among an elderly Korean population. / 06.2018 / PubMed / Full text
Blood Pressure Trajectories in the 20 Years Before Death. / 01.01.2018 / PubMed / Full text
Determinants of carotid-femoral pulse wave velocity progression in hypertensive patients over a 3.7 years follow-up. / 02.2018 / PubMed / Full text
Associations between Greenness, Impervious Surface Area, and Nighttime Lights on Biomarkers of Vascular Aging in Chennai, India. / 02.08.2017 / PubMed / Full text

CD34

Comparing the Effect of TGF-β Receptor Inhibition on Human Perivascular Mesenchymal Stromal Cells Derived from Endometrium, Bone Marrow and Adipose Tissues. / 01.12.2020 / PubMed / Full text
ACE2/ACE imbalance and impaired vasoreparative functions of stem/progenitor cells in aging. / 27.11.2020 / PubMed / Full text
Innovative Mind-Body Intervention Day Easy Exercise Increases Peripheral Blood CD34 Cells in Adults. / 01-12.2020 / PubMed / Full text
Human Thymic Involution and Aging in Humanized Mice. / 2020 / PubMed / Full text
Coinhibition of activated p38 MAPKα and mTORC1 potentiates stemness maintenance of HSCs from SR1-expanded human cord blood CD34 cells via inhibition of senescence. / 12.2020 / PubMed / Full text
Bulk and single-cell gene expression analyses reveal aging human choriocapillaris has pro-inflammatory phenotype. / 09.2020 / PubMed / Full text
Mesenchymal stem cells repair bone marrow damage of aging rats and regulate autophagy and aging genes. / 08.2020 / PubMed / Full text
Immune cell extracellular vesicles and their mitochondrial content decline with ageing. / 2020 / PubMed / Full text
Young and elderly oral squamous cell carcinoma patients present similar angiogenic profile and predominance of M2 macrophages: Comparative immunohistochemical study. / 12.2019 / PubMed / Full text
HIV-mediated immune aging in young adults infected perinatally or during childhood. / 01.09.2019 / PubMed / Full text
Immunophenotypic characterization, multi-lineage differentiation and aging of zebrafish heart and liver tissue-derived mesenchymal stem cells as a novel approach in stem cell-based therapy. / 04.2019 / PubMed / Full text
Cardio-ankle vascular index and circulating CD34-positive cell levels as indicators of endothelial repair activity in older Japanese men. / 06.2019 / PubMed / Full text
Role of apoptotic, autophagic and senescence pathways in minor salivary gland adenoid cystic carcinoma. / 08.02.2019 / PubMed / Full text
Dynamic regulation of NOTCH1 activation and Notch ligand expression in human thymus development. / 13.08.2018 / PubMed / Full text
Therapeutic efficacy of olfactory stem cells in rotenone induced Parkinsonism in adult male albino rats. / 07.2018 / PubMed / Full text
Gender and age-related cell compositional differences in C57BL/6 murine adipose tissue stromal vascular fraction. / 2018 / PubMed / Full text
Endothelial progenitor cells from aged subjects display decreased expression of sirtuin 1, angiogenic functions, and increased senescence. / 09.2018 / PubMed / Full text
Precise Intradermal Injection of Nanofat-Derived Stromal Cells Combined with Platelet-Rich Fibrin Improves the Efficacy of Facial Skin Rejuvenation. / 2018 / PubMed / Full text
Human nail stem cells are retained but hypofunctional during aging. / 06.2018 / PubMed / Full text
Hair Follicle Stem Cell Faith Is Dependent on Chromatin Remodeling Capacity Following Low-Dose Radiation. / 04.2018 / PubMed / Full text
Developmental differences between neonatal and adult human erythropoiesis. / 08.2018 / PubMed / Full text
Normal variation of bone marrow B-cell precursors according to age - reference ranges for studies in myelodysplastic syndromes in Brazil. / 09.2018 / PubMed / Full text
Aging process, adherence to Mediterranean diet and nutritional status in a large cohort of nonagenarians: Effects on endothelial progenitor cells. / 01.2018 / PubMed / Full text
Lower resting and exercise-induced circulating angiogenic progenitors and angiogenic T cells in older men. / 01.03.2018 / PubMed / Full text

IGF1

Genetic differences and longevity-related phenotypes influence lifespan and lifespan variation in a sex-specific manner in mice. / 11.2020 / PubMed / Full text
17α-estradiol modulates IGF1 and hepatic gene expression in a sex-specific manner. / 28.08.2020 / PubMed / Full text
Pan-mammalian analysis of molecular constraints underlying extended lifespan. / 11.02.2020 / PubMed / Full text
17α-Estradiol promotes ovarian aging in growth hormone receptor knockout mice, but not wild-type littermates. / 01.2020 / PubMed / Full text
Reducing INS-IGF1 signaling protects against non-cell autonomous vesicle rupture caused by SNCA spreading. / 05.2020 / PubMed / Full text
Are There Common Mechanisms Between the Hutchinson-Gilford Progeria Syndrome and Natural Aging? / 2019 / PubMed / Full text
Lactoferrin ameliorates aging-suppressed osteogenesis via IGF1 signaling. / 07.2019 / PubMed / Full text
[i]TP53[/i] Tumor-suppressor Gene Plays a Key Role in IGF1 Signaling Pathway Related to the Aging of Human Melanocytes. / 05.2019 / PubMed / Full text
Involvement of insulin receptor substrates in cognitive impairment and Alzheimer's disease. / 08.2019 / PubMed / Full text
In mice transgenic for IGF1 under keratin-14 promoter, lifespan is decreased and the rates of aging and thymus involution are accelerated. / 13.04.2019 / PubMed / Full text
IGF1 Gene Therapy Modifies Microglia in the Striatum of Senile Rats. / 2019 / PubMed / Full text
Novel biomolecules of ageing, sex differences and potential underlying mechanisms of telomere shortening in coronary artery disease. / 05.2019 / PubMed / Full text
Growth signaling and longevity in mouse models. / 01.2019 / PubMed / Full text
IGF-1 Gene Therapy as a Potentially Useful Therapy for Spontaneous Prolactinomas in Senile Rats. / 2018 / PubMed / Full text
A framework for selection of blood-based biomarkers for geroscience-guided clinical trials: report from the TAME Biomarkers Workgroup. / 12.2018 / PubMed / Full text
Matrine induces senescence of human glioblastoma cells through suppression of the IGF1/PI3K/AKT/p27 signaling pathway. / 09.2018 / PubMed / Full text
Composition and richness of the serum microbiome differ by age and link to systemic inflammation. / 06.2018 / PubMed / Full text
40 YEARS of IGF1: IGF1: the Jekyll and Hyde of the aging brain. / 07.2018 / PubMed / Full text
De-silencing [i]Grb10[/i] contributes to acute ER stress-induced steatosis in mouse liver. / 05.2018 / PubMed / Full text
Long-lived rodents reveal signatures of positive selection in genes associated with lifespan. / 03.2018 / PubMed / Full text
Activation of DAF-16/FOXO by reactive oxygen species contributes to longevity in long-lived mitochondrial mutants in Caenorhabditis elegans. / 03.2018 / PubMed / Full text
Withanolide A extends the lifespan in human EGFR-driven cancerous Caenorhabditis elegans. / 04.2018 / PubMed / Full text
Caloric restriction stabilizes body weight and accelerates behavioral recovery in aged rats after focal ischemia. / 12.2017 / PubMed / Full text
Molecular signatures of longevity: Insights from cross-species comparative studies. / 10.2017 / PubMed / Full text

MIP

Inspiratory muscle training improves cerebrovascular and postural control responses during orthostatic stress in older women. / 10.2020 / PubMed / Full text
A novel multi-marker discovery approach identifies new serum biomarkers for Parkinson's disease in older people: an EXosomes in PArkiNson Disease (EXPAND) ancillary study. / 10.2020 / PubMed / Full text
Sexual dimorphism of physical activity on cognitive aging: Role of immune functioning. / 08.2020 / PubMed / Full text
Comparison of balance changes after inspiratory muscle or Otago exercise training. / 2020 / PubMed / Full text
[i]Lactobacillus acidophilus[/i] DDS-1 Modulates Intestinal-Specific Microbiota, Short-Chain Fatty Acid and Immunological Profiles in Aging Mice. / 07.06.2019 / PubMed / Full text
Systemic inflammation contributes to impairment of quality of life in chronic pancreatitis. / 13.05.2019 / PubMed / Full text
Open Mouth-Maximal Isometric Press: Development and Norms for Clinical Swallowing Evaluations and Treatment. / 21.02.2019 / PubMed / Full text
A New Understanding of the Role of IL-1 in Age-Related Intervertebral Disc Degeneration in a Murine Model. / 08.2019 / PubMed / Full text
Novel Chitohexaose Analog Protects Young and Aged mice from CLP Induced Polymicrobial Sepsis. / 27.02.2019 / PubMed / Full text
Inflammation and Monocyte Recruitment due to Aging and Mechanical Stretch in Alveolar Epithelium are Inhibited by the Molecular Chaperone 4-phenylbutyrate. / 12.2018 / PubMed / Full text
Prophylactic Palmitoylethanolamide Prolongs Survival and Decreases Detrimental Inflammation in Aged Mice With Bacterial Meningitis. / 2018 / PubMed / Full text
Establishment of a lethal aged mouse model of human respiratory syncytial virus infection. / 01.2019 / PubMed / Full text
Mitochondrial DNA variants and pulmonary function in older persons. / 01.2019 / PubMed / Full text
Respiratory Muscle Strength as a Discriminator of Sarcopenia in Community-Dwelling Elderly: A Cross-Sectional Study. / 2018 / PubMed / Full text
The Role of Pulmonary and Systemic Immunosenescence in Acute Lung Injury. / 08.2018 / PubMed / Full text
Cortical and hippocampal expression of inflammatory and intracellular signaling proteins in aged rats submitted to aerobic and resistance physical training. / 09.2018 / PubMed / Full text
Age-Related Changes to Human Tear Composition. / 01.04.2018 / PubMed / Full text
Sex Differences in Adipose Tissue CD8 T Cells and Regulatory T Cells in Middle-Aged Mice. / 2018 / PubMed / Full text
Reaction time in healthy elderly is associated with chronic low-grade inflammation and advanced glycation end product. / 15.07.2018 / PubMed / Full text
Inspiratory muscle training improves physical performance and cardiac autonomic modulation in older women. / 06.2018 / PubMed / Full text
Cerebrospinal Fluid and Plasma Levels of Inflammation Differentially Relate to CNS Markers of Alzheimer's Disease Pathology and Neuronal Damage. / 2018 / PubMed / Full text
Skeletal Muscle Injury Biomarkers: Assay Qualification Efforts and Translation to the Clinic. / 10.2017 / PubMed / Full text
Brainstem cytokine changes in healthy ageing and Motor Neurone Disease. / 15.10.2017 / PubMed / Full text
Validity of maximum isometric tongue pressure as a screening test for physical frailty: Cross-sectional study of Japanese community-dwelling older adults. / 02.2018 / PubMed / Full text

PINK1

Spermidine inhibits neurodegeneration and delays aging via the PINK1-PDR1-dependent mitophagy pathway in [i]C. elegans[/i]. / 09.09.2020 / PubMed / Full text
Female mice are resilient to age-related decline of substantia nigra dopamine neuron firing parameters. / 11.2020 / PubMed / Full text
Attenuation of epigenetic regulator SMARCA4 and ERK-ETS signaling suppresses aging-related dopaminergic degeneration. / 09.2020 / PubMed / Full text
SIRT1 alleviates high-magnitude compression-induced senescence in nucleus pulposus cells via PINK1-dependent mitophagy. / 18.07.2020 / PubMed / Full text
Synergistic action of propolis with levodopa in the management of Parkinsonism in Drosophila melanogaster. / 23.09.2020 / PubMed / Full text
Compression-induced senescence of nucleus pulposus cells by promoting mitophagy activation via the PINK1/PARKIN pathway. / 05.2020 / PubMed / Full text
Doxorubicin-induced normal breast epithelial cellular aging and its related breast cancer growth through mitochondrial autophagy and oxidative stress mitigated by ginsenoside Rh2. / 07.2020 / PubMed / Full text
Mitochondrial DNA heteroplasmy rises in substantial nigra of aged PINK1 KO mice. / 22.01.2020 / PubMed / Full text
Late life maintenance and enhancement of functional exercise capacity in low and high responding rats after low intensity treadmill training. / 01.10.2019 / PubMed / Full text
SerThr-PhosphoProteome of Brain from Aged PINK1-KO+A53T-SNCA Mice Reveals pT1928-MAP1B and pS3781-ANK2 Deficits, as Hub between Autophagy and Synapse Changes. / 04.07.2019 / PubMed / Full text
Neuronal Mitophagy: Lessons from a Pathway Linked to Parkinson's Disease. / 08.2019 / PubMed / Full text
Inhibition of the deubiquitinase USP8 corrects a Drosophila PINK1 model of mitochondria dysfunction. / 04.2019 / PubMed / Full text
Oligonol Alleviates Sarcopenia by Regulation of Signaling Pathways Involved in Protein Turnover and Mitochondrial Quality. / 05.2019 / PubMed / Full text
AMP Kinase Activation is Selectively Disrupted in the Ventral Midbrain of Mice Deficient in Parkin or PINK1 Expression. / 03.2019 / PubMed / Full text
Intensified mitophagy in skeletal muscle with aging is downregulated by PGC-1alpha overexpression in vivo. / 01.2019 / PubMed / Full text
Melatonin protects chronic kidney disease mesenchymal stem cells against senescence via PrP -dependent enhancement of the mitochondrial function. / 01.2019 / PubMed / Full text
PRKN-regulated mitophagy and cellular senescence during COPD pathogenesis. / 03.2019 / PubMed / Full text
Grape skin extract improves muscle function and extends lifespan of a Drosophila model of Parkinson's disease through activation of mitophagy. / 11.2018 / PubMed / Full text
Imaging mitophagy in the fruit fly. / 2018 / PubMed / Full text
Age- and disease-dependent increase of the mitophagy marker phospho-ubiquitin in normal aging and Lewy body disease. / 2018 / PubMed / Full text
PINK1 protects against oxidative stress induced senescence of human nucleus pulposus cells via regulating mitophagy. / 02.10.2018 / PubMed / Full text
Deficiency of parkin and PINK1 impairs age-dependent mitophagy in [i]Drosophila[/i]. / 29.05.2018 / PubMed / Full text
ATF3 represses PINK1 gene transcription in lung epithelial cells to control mitochondrial homeostasis. / 04.2018 / PubMed / Full text
In vivo imaging reveals mitophagy independence in the maintenance of axonal mitochondria during normal aging. / 10.2017 / PubMed / Full text

SI

Microarray Profiling Reveals Distinct Circulating miRNAs in Aged Male and Female Mice Subjected to Post-stroke Social Isolation. / 19.10.2020 / PubMed / Full text
Is Heart Rate a Confounding Factor for Photoplethysmography Markers? A Systematic Review. / 10.04.2020 / PubMed / Full text
Survival time after marked reduction in oral intake in terminally ill noncancer patients: A retrospective study. / 03.2020 / PubMed / Full text
Adherence to Mediterranean diet moderates the association between multimorbidity and depressive symptoms in older adults. / 05-06.2020 / PubMed / Full text
Loneliness, Social Isolation, and Objectively Measured Physical Activity in Rural-Living Older Adults. / 19.12.2019 / PubMed / Full text
The associations between social support and negative social interaction with suicidal ideation in US Chinese older adults. / 25.10.2019 / PubMed / Full text
Cell Senescence and Cerebral Small Vessel Disease in the Brains of People Aged 80 Years and Older. / 01.11.2019 / PubMed / Full text
Clinical findings associated with development of postoperative reflux and short-term survival after small intestinal surgery in geriatric and mature nongeriatric horses. / 07.2019 / PubMed / Full text
Saving inventory - Revised: Psychometric performance across the lifespan. / 01.06.2019 / PubMed / Full text
Effects of aerobic fitness on cognitive performance as a function of dual-task demands in older adults. / 04.2019 / PubMed / Full text
Predictors of neurodegeneration differ between cognitively normal and subsequently impaired older adults. / 03.2019 / PubMed / Full text
Age-related changes in interstitial fibrosis and germ cell degeneration of the canine testis. / 11.2018 / PubMed / Full text
Total energy intake according to the level of skeletal muscle mass in Korean adults aged 30 years and older: an analysis of the Korean National Health and Nutrition Examination Surveys (KNHANES) 2008-2011. / 06.2018 / PubMed / Full text
Differences in response inhibition processes between adolescents and adults are modulated by sensory processes. / 06.2018 / PubMed / Full text
The role of plant size in the selection of glyphosate resistance in Sorghum halepense. / 11.2018 / PubMed / Full text
Age Effect on Automatic Inhibitory Function of the Somatosensory and Motor Cortex: An MEG Study. / 2018 / PubMed / Full text
Gender differences in health expenditure determinants: A follow-up study. / 01.2019 / PubMed / Full text
Age-related cognitive impairment is associated with long-term neuroinflammation and oxidative stress in a mouse model of episodic systemic inflammation. / 30.01.2018 / PubMed / Full text
Effects of age and diet on glucose and insulin dynamics in the horse. / 09.2018 / PubMed / Full text
Do the antecedents and consequences of loneliness change from middle adulthood into old age? / 01.2018 / PubMed / Full text
Self-initiated spatial working memory in young and older adults. / 05.2018 / PubMed / Full text
Effect of Gene [i]act[/i]A on the Invasion Efficiency of [i]Listeria monocytogenes[/i], as Observed in Healthy and Senescent Intestinal Epithelial Cells. / 28.01.2018 / PubMed / Full text
[Effect of resveratrol on forelimb grip strength and myofibril structure in aged rats]. / 20.10.2017 / PubMed / Full text
Effect of age and dietary carbohydrate profiles on glucose and insulin dynamics in horses. / 03.2018 / PubMed / Full text

FOXO3

The DNA methylation of FOXO3 and TP53 as a blood biomarker of late-onset asthma. / 09.12.2020 / PubMed / Full text
FOXO3 targets are reprogrammed as Huntington's disease neural cells and striatal neurons face senescence with p16 increase. / 11.2020 / PubMed / Full text
Astaxanthin as a Putative Geroprotector: Molecular Basis and Focus on Brain Aging. / 05.07.2020 / PubMed / Full text
Inflamma-miR-21 Negatively Regulates Myogenesis during Ageing. / 23.04.2020 / PubMed / Full text
Variable DNA methylation of aging-related genes is associated with male COPD. / 04.11.2019 / PubMed / Full text
A conserved role of the insulin-like signaling pathway in diet-dependent uric acid pathologies in Drosophila melanogaster. / 08.2019 / PubMed / Full text
FOXO3 on the Road to Longevity: Lessons From SNPs and Chromatin Hubs. / 2019 / PubMed / Full text
Longevity-Associated Forkhead Box O3 (FOXO3) Single Nucleotide Polymorphisms are Associated with Type 2 Diabetes Mellitus in Chinese Elderly Women. / 22.04.2019 / PubMed / Full text
Signal Transduction, Ageing and Disease. / 2019 / PubMed / Full text
FOXO3, a Molecular Search for the Fountain of Youth. / 07.03.2019 / PubMed / Full text
10-year follow-up of the Super-Seniors Study: compression of morbidity and genetic factors. / 28.02.2019 / PubMed / Full text
Taste receptors, innate immunity and longevity: the case of TAS2R16 gene. / 2019 / PubMed / Full text
FOXO3-Engineered Human ESC-Derived Vascular Cells Promote Vascular Protection and Regeneration. / 07.03.2019 / PubMed / Full text
Analysis of FOXO3 Gene Polymorphisms Associated with Human Longevity. / 2019 / PubMed / Full text
Recent advances in understanding the role of FOXO3. / 2018 / PubMed / Full text
FOXO are required for intervertebral disk homeostasis during aging and their deficiency promotes disk degeneration. / 10.2018 / PubMed / Full text
The longevity SNP rs2802292 uncovered: HSF1 activates stress-dependent expression of FOXO3 through an intronic enhancer. / 20.06.2018 / PubMed / Full text
Minimal Shortening of Leukocyte Telomere Length Across Age Groups in a Cross-Sectional Study for Carriers of a Longevity-Associated FOXO3 Allele. / 08.10.2018 / PubMed / Full text
FOXO in Neural Cells and Diseases of the Nervous System. / 2018 / PubMed / Full text
Genetic Variation in FOXO3 is Associated with Self-Rated Health in a Population-Based Sample of Older Individuals. / 08.10.2018 / PubMed / Full text
Identification and characterization of two functional variants in the human longevity gene FOXO3. / 12.12.2017 / PubMed / Full text
Effects of FOXO3 Polymorphisms on Survival to Extreme Longevity in Four Centenarian Studies. / 08.10.2018 / PubMed / Full text
FOXO Transcriptional Factors and Long-Term Living. / 2017 / PubMed / Full text

CD38

Re-equilibration of imbalanced NAD metabolism ameliorates the impact of telomere dysfunction. / 02.11.2020 / PubMed / Full text
TNFRSF12A and CD38 Contribute to a Vicious Circle for Chronic Obstructive Pulmonary Disease by Engaging Senescence Pathways. / 2020 / PubMed / Full text
Aging alters acetylation status in skeletal and cardiac muscles. / 06.2020 / PubMed / Full text
CD38 in Neurodegeneration and Neuroinflammation. / 18.02.2020 / PubMed / Full text
CD38, a Receptor with Multifunctional Activities: From Modulatory Functions on Regulatory Cell Subsets and Extracellular Vesicles, to a Target for Therapeutic Strategies. / 27.11.2019 / PubMed / Full text
CD38 Deficiency Alleviates D-Galactose-Induced Myocardial Cell Senescence Through NAD /Sirt1 Signaling Pathway. / 2019 / PubMed / Full text
The Multi-faceted Ecto-enzyme CD38: Roles in Immunomodulation, Cancer, Aging, and Metabolic Diseases. / 2019 / PubMed / Full text
Interacting NAD and Cell Senescence Pathways Complicate Antiaging Therapies. / 06.2019 / PubMed / Full text
The NADase CD38 is induced by factors secreted from senescent cells providing a potential link between senescence and age-related cellular NAD decline. / 28.05.2019 / PubMed / Full text
Measuring CD38 Hydrolase and Cyclase Activities: 1,N -Ethenonicotinamide Adenine Dinucleotide (ε-NAD) and Nicotinamide Guanine Dinucleotide (NGD) Fluorescence-based Methods. / 20.07.2018 / PubMed / Full text
The Plasma NAD Metabolome Is Dysregulated in "Normal" Aging. / 04.2019 / PubMed / Full text
Assays for NAD -Dependent Reactions and NAD Metabolites. / 2018 / PubMed / Full text
Decreased NAD Activates STAT3 and Integrin Pathways to Drive Epithelial-Mesenchymal Transition. / 10.2018 / PubMed / Full text
Innate and adaptive immune dysregulation in critically ill ICU patients. / 05.07.2018 / PubMed / Full text
Abnormalities of age-related T cell senescence in Parkinson's disease. / 28.05.2018 / PubMed / Full text
A Potent and Specific CD38 Inhibitor Ameliorates Age-Related Metabolic Dysfunction by Reversing Tissue NAD Decline. / 01.05.2018 / PubMed / Full text
Role of Nicotinamide Adenine Dinucleotide and Related Precursors as Therapeutic Targets for Age-Related Degenerative Diseases: Rationale, Biochemistry, Pharmacokinetics, and Outcomes. / 10.01.2019 / PubMed / Full text
Hyper-Expression of PD-1 Is Associated with the Levels of Exhausted and Dysfunctional Phenotypes of Circulating CD161 TCR iVα7.2 Mucosal-Associated Invariant T Cells in Chronic Hepatitis B Virus Infection. / 2018 / PubMed / Full text
The Pharmacology of CD38/NADase: An Emerging Target in Cancer and Diseases of Aging. / 04.2018 / PubMed / Full text
NAD Deficiency Is a Common Central Pathological Factor of a Number of Diseases and Aging: Mechanisms and Therapeutic Implications. / 20.02.2019 / PubMed / Full text
Reevaluation of immune activation in the era of cART and an aging HIV-infected population. / 19.10.2017 / PubMed / Full text
Altered marginal zone and innate-like B cells in aged senescence-accelerated SAMP8 mice with defective IgG1 responses. / 17.08.2017 / PubMed / Full text

IL6

Basic immunology may lead to translational therapeutic rationale: SARS-CoV-2 and rheumatic diseases. / 09.2020 / PubMed / Full text
ATM-deficient neural precursors develop senescence phenotype with disturbances in autophagy. / 09.2020 / PubMed / Full text
The microRNA-34a-Induced Senescence-Associated Secretory Phenotype (SASP) Favors Vascular Smooth Muscle Cells Calcification. / 23.06.2020 / PubMed / Full text
Impact of Influenza on Pneumococcal Vaccine Effectiveness during [i]Streptococcus pneumoniae[/i] Infection in Aged Murine Lung. / 11.06.2020 / PubMed / Full text
Patterns of multi-domain cognitive aging in participants of the Long Life Family Study. / 10.2020 / PubMed / Full text
Cholest-4,6-Dien-3-One Promote Epithelial-To-Mesenchymal Transition (EMT) in Biliary Tree Stem/Progenitor Cell Cultures In Vitro. / 15.11.2019 / PubMed / Full text
Single xenotransplant of rat brown adipose tissue prolonged the ovarian lifespan of aging mice by improving follicle survival. / 12.2019 / PubMed / Full text
Intestinal stem cells acquire premature senescence and senescence associated secretory phenotype concurrent with persistent DNA damage after heavy ion radiation in mice. / 25.06.2019 / PubMed / Full text
N-acetylcysteine and alpha-lipoic acid improve antioxidant defenses and decrease oxidative stress, inflammation and serum lipid levels in ovariectomized rats via estrogen-independent mechanisms. / 05.2019 / PubMed / Full text
Age-dependent hepatic alterations induced by a high-fat high-fructose diet. / 05.2019 / PubMed / Full text
Protective effects of a novel facial cream against environmental pollution: in vivo and in vitro assessment. / 2018 / PubMed / Full text
Expression of pro- and anti-inflammatory cytokines and chemokines during the ovulatory cycle and effects of aging on their expression in the uterine mucosa of laying hens. / 11.2018 / PubMed / Full text
Torquetenovirus (TTV) load is associated with mortality in Italian elderly subjects. / 02.10.2018 / PubMed / Full text
Review and meta-analysis of genetic polymorphisms associated with exceptional human longevity. / 10.2018 / PubMed / Full text
Composition and richness of the serum microbiome differ by age and link to systemic inflammation. / 06.2018 / PubMed / Full text
Interleukin 6 Knockout Inhibits Aging-Related Accumulation of p53 in the Mouse Myocardium. / 16.01.2019 / PubMed / Full text
Age Dependent Hypothalamic and Pituitary Responses to Novel Environment Stress or Lipopolysaccharide in Rats. / 2018 / PubMed / Full text
Sulodexide Slows Down the Senescence of Aortic Endothelial Cells Exposed to Serum from Patients with Peripheral Artery Diseases. / 2018 / PubMed / Full text
Dexamethasone downregulates SIRT1 and IL6 and upregulates EDN1 genes in stem cells derived from gingivae via the AGE/RAGE pathway. / 03.2018 / PubMed / Full text
Senescence promotes in vivo reprogramming through p16 and IL-6. / 04.2018 / PubMed / Full text
Predictive value of multiple cytokines and chemokines for mortality in an admixed population: 15-year follow-up of the Bambui-Epigen (Brazil) cohort study of aging. / 11.2017 / PubMed / Full text
Voluntary running exercise protects against sepsis-induced early inflammatory and pro-coagulant responses in aged mice. / 08.08.2017 / PubMed / Full text

PCNA

Impairment of Pol β-related DNA Base-excision Repair Leads to Ovarian Aging in Mice. / 20.11.2020 / PubMed / Full text
[Heat shock protein 90 (HSP90) in age-dependent changes in the number of fibroblasts in human skin.] / 2020 / PubMed
A Higher Frequency Administration of the Nontoxic Cycloartane-Type Triterpene Argentatin A Improved Its Anti-Tumor Activity. / 14.04.2020 / PubMed / Full text
[Mechanosensitive protein of Hippo regulatory pathway - transcription coactivator with PZD-binding motif (TAZ) in human skin during aging.] / 2019 / PubMed
[Mechanosensitive Yes-associated protein in human skin during aging.] / 2019 / PubMed
[Role of mechanosensitive protein Piezo1 in human age-dependent changes in the number of fibroblasts and blood vessels in human skin.] / 2019 / PubMed
Ageing in men with normal spermatogenesis alters spermatogonial dynamics and nuclear morphology in Sertoli cells. / 11.2019 / PubMed / Full text
Intestinal stem cells acquire premature senescence and senescence associated secretory phenotype concurrent with persistent DNA damage after heavy ion radiation in mice. / 25.06.2019 / PubMed / Full text
[Transforming growth factor-β (TGF-β) in human skin in the process of aging.] / 2019 / PubMed
Human Hippocampal Neurogenesis Persists in Aged Adults and Alzheimer's Disease Patients. / 06.06.2019 / PubMed / Full text
High maternal milk intake in the postnatal life reduces the incidence of breast cancer during adulthood in rats. / 08.2019 / PubMed / Full text
Prepubertal exposure to perfluorononanoic acid interferes with spermatogenesis and steroidogenesis in male mice. / 15.04.2019 / PubMed / Full text
Age Influences Microglial Activation After Cuprizone-Induced Demyelination. / 2018 / PubMed / Full text
Genome Instability Is Promoted by the Chromatin-Binding Protein Spn1 in [i]Saccharomyces cerevisiae[/i]. / 12.2018 / PubMed / Full text
MicroRNA-338-5p plays a tumor suppressor role in glioma through inhibition of the MAPK-signaling pathway by binding to FOXD1. / 12.2018 / PubMed / Full text
Conditioned medium from stimulated macrophages inhibits growth but induces an inflammatory phenotype in breast cancer cells. / 10.2018 / PubMed / Full text
[Thyroid hormone receptors in human skin during aging.] / 2018 / PubMed
Xanthohumol exerts protective effects in liver alterations associated with aging. / 03.2019 / PubMed / Full text
Comparison of naturally aging and D-galactose induced aging model in beagle dogs. / 12.2017 / PubMed / Full text
An Extract from the Plant [i]Deschampsia antarctica[/i] Protects Fibroblasts from Senescence Induced by Hydrogen Peroxide. / 2017 / PubMed / Full text
[Age-related changes in the expression of lamin B receptors in fibroblasts of human dermis]. / 2017 / PubMed
Morphological alterations in the jejunal mucosa of aged rats and the possible protective role of green tea. / 2017 / PubMed / Full text

CD68

Insulin activates microglia and increases COX-2/IL-1β expression in young but not in aged hippocampus. / 15.08.2020 / PubMed / Full text
Epigenetic modulation of macrophage polarization prevents lumbar disc degeneration. / 20.04.2020 / PubMed / Full text
Cellular senescence in recurrent tonsillitis and tonsillar hypertrophy in children. / 06.2020 / PubMed / Full text
Ginsenoside Rg1 supplementation clears senescence-associated β-galactosidase in exercising human skeletal muscle. / 10.2019 / PubMed / Full text
Histopathological, immunohistochemical, and molecular studies for determination of wound age and vitality in rats. / 12.2019 / PubMed / Full text
Metabotropic glutamate receptor 5 ablation accelerates age-related neurodegeneration and neuroinflammation. / 06.2019 / PubMed / Full text
Iba-1-/CD68+ microglia are a prominent feature of age-associated deep subcortical white matter lesions. / 2019 / PubMed / Full text
Forced turnover of aged microglia induces an intermediate phenotype but does not rebalance CNS environmental cues driving priming to immune challenge. / 26.11.2018 / PubMed / Full text
Partial reduction of microglia does not affect tau pathology in aged mice. / 09.11.2018 / PubMed / Full text
Effects of pepsin and pepstatin on reflux tonsil hypertrophy in vitro. / 2018 / PubMed / Full text
Age Influences Microglial Activation After Cuprizone-Induced Demyelination. / 2018 / PubMed / Full text
Pathology and Distribution of Trombiculosis in Northern Chamois ( Rupicapra rupicapra rupicapra) in the Italian Alps. / 01.2019 / PubMed / Full text
Stem Cell-Induced Pulp Regeneration Can Be Enhanced by Administration of CCL11-Neutralizing Antibody in the Ectopic Tooth Transplantation Model in the Aged Mice. / 02.2019 / PubMed / Full text
Pro- and Anti-inflammatory Effects of High Cholesterol Diet on Aged Brain. / 06.2018 / PubMed / Full text
Chia Seed Supplementation Reduces Senescence Markers in Epididymal Adipose Tissue of High-Fat Diet-Fed SAMP8 Mice. / 08.2018 / PubMed / Full text
Lifelong environmental enrichment in the absence of exercise protects the brain from age-related cognitive decline. / 02.2019 / PubMed / Full text
Age Dependent Hypothalamic and Pituitary Responses to Novel Environment Stress or Lipopolysaccharide in Rats. / 2018 / PubMed / Full text
Secreted Klotho Attenuates Inflammation-Associated Aortic Valve Fibrosis in Senescence-Accelerated Mice P1. / 05.2018 / PubMed / Full text
Salidroside attenuates endothelial cellular senescence via decreasing the expression of inflammatory cytokines and increasing the expression of SIRT3. / 10.2018 / PubMed / Full text
The age-related slow increase in amyloid pathology in APP.V717I mice activates microglia, but does not alter hippocampal neurogenesis. / 01.2018 / PubMed / Full text
Morphological alterations in the jejunal mucosa of aged rats and the possible protective role of green tea. / 2017 / PubMed / Full text

FGF21

Differential effects of sulfur amino acid-restricted and low-calorie diets on gut microbiome profile and bile acid composition in male C57BL6/J mice. / 27.10.2020 / PubMed / Full text
Relationship between physical activity and circulating fibroblast growth factor 21 in middle-aged and older adults. / 11.2020 / PubMed / Full text
Exercise and dietary intervention ameliorate high-fat diet-induced NAFLD and liver aging by inducing lipophagy. / 09.2020 / PubMed / Full text
Mitochondria, immunosenescence and inflammaging: a role for mitokines? / 10.2020 / PubMed / Full text
Age-at-onset-dependent effects of sulfur amino acid restriction on markers of growth and stress in male F344 rats. / 07.2020 / PubMed / Full text
Fibroblast growth factor 21 prolongs lifespan and improves stress tolerance in the silkworm, [i]Bombyx mori[/i]. / 03.2020 / PubMed / Full text
Neurogenesis and prolongevity signaling in young germ-free mice transplanted with the gut microbiota of old mice. / 13.11.2019 / PubMed / Full text
Fibroblast Growth Factor 21 Mediates the Associations between Exercise, Aging, and Glucose Regulation. / 02.2020 / PubMed / Full text
Effects of Moderate Chronic Food Restriction on the Development of Postprandial Dyslipidemia with Ageing. / 10.08.2019 / PubMed / Full text
Inhibition of the Fission Machinery Mitigates OPA1 Impairment in Adult Skeletal Muscles. / 15.06.2019 / PubMed / Full text
Higher serum levels of fibroblast growth factor 21 in old patients with cachexia. / 07-08.2019 / PubMed / Full text
Impact of aging and caloric restriction on fibroblast growth factor 21 signaling in rat white adipose tissue. / 04.2019 / PubMed / Full text
Kotho and aging. / 09.2016 / PubMed
The Klotho proteins in health and disease. / 01.2019 / PubMed / Full text
Towards frailty biomarkers: Candidates from genes and pathways regulated in aging and age-related diseases. / 11.2018 / PubMed / Full text
Aging is associated with increased FGF21 levels but unaltered FGF21 responsiveness in adipose tissue. / 10.2018 / PubMed / Full text
Genome-wide meta-analysis of macronutrient intake of 91,114 European ancestry participants from the cohorts for heart and aging research in genomic epidemiology consortium. / 12.2019 / PubMed / Full text
Human Aging and Longevity Are Characterized by High Levels of Mitokines. / 23.04.2019 / PubMed / Full text
[Fibroblast growth factor-21 as a marker of premature aging in young and middled-aged men with type 2 diabetes]. / 03.2018 / PubMed
Fibroblast growth factor 21 delayed endothelial replicative senescence and protected cells from H O -induced premature senescence through SIRT1. / 2017 / PubMed / Full text
Integrated stress response stimulates FGF21 expression: Systemic enhancer of longevity. / 12.2017 / PubMed / Full text

IVD

MicroRNAs in Intervertebral Disc Degeneration, Apoptosis, Inflammation, and Mechanobiology. / 20.05.2020 / PubMed / Full text
A step-by-step protocol for isolation of murine nucleus pulposus cells. / 12.2019 / PubMed / Full text
Caspase-3 knockout inhibits intervertebral disc degeneration related to injury but accelerates degeneration related to aging. / 18.12.2019 / PubMed / Full text
Finite element and deformation analyses predict pattern of bone failure in loaded zebrafish spines. / 29.11.2019 / PubMed / Full text
Improvement in determining the risk of damage to the human lumbar functional spinal unit considering age, height, weight and sex using a combination of FEM and RSM. / 02.2020 / PubMed / Full text
In vivo contrast-enhanced microCT for the monitoring of mouse thoracic, lumbar, and coccygeal intervertebral discs. / 06.2019 / PubMed / Full text
MicroRNA-143-5p targeting eEF2 gene mediates intervertebral disc degeneration through the AMPK signaling pathway. / 15.04.2019 / PubMed / Full text
Curcumin and o-Vanillin Exhibit Evidence of Senolytic Activity in Human IVD Cells In Vitro. / 29.03.2019 / PubMed / Full text
Aging of mouse intervertebral disc and association with back pain. / 06.2019 / PubMed / Full text
Role of heparan sulfate 6-0 endosulfatases in intervertebral disc homeostasis. / 09.2019 / PubMed / Full text
Evaluation of age-related changes in lumbar facet joints using T2 mapping. / 01.2020 / PubMed / Full text
A histocytological and radiological overview of the natural history of intervertebral disk: from embryonic formation to age-related degeneration. / 04.2019 / PubMed / Full text
Regenerative potential of human nucleus pulposus resident stem/progenitor cells declines with ageing and intervertebral disc degeneration. / 10.2018 / PubMed / Full text
TRPC6 in simulated microgravity of intervertebral disc cells. / 10.2018 / PubMed / Full text
FOXO are required for intervertebral disk homeostasis during aging and their deficiency promotes disk degeneration. / 10.2018 / PubMed / Full text
Major traits of the senescent phenotype of nucleus pulposus intervertebral disc cells persist under the specific microenvironmental conditions of the tissue. / 01.2019 / PubMed / Full text
[Influence analysis of aging of spinal segment on the mechanical behavior of vertebral cortex]. / 01.06.2017 / PubMed / Full text
The adolescent idiopathic scoliotic IVD displays advanced aggrecanolysis and a glycosaminoglycan composition similar to that of aged human and ovine IVDs. / 09.2018 / PubMed / Full text
Costs and benefits of diagnostic testing: four ways to improve patient care by purposive use of in vitro diagnostics. / 2017 / PubMed / Full text
Matrisome Profiling During Intervertebral Disc Development And Ageing. / 14.09.2017 / PubMed / Full text
Age-related decline in AMH is assay dependent limiting clinical interpretation of repeat AMH measures across the reproductive lifespan. / 02.2018 / PubMed / Full text

LMNA

Metformin alters peripheral blood mononuclear cells (PBMC) senescence biomarkers gene expression in type 2 diabetic patients. / 01.2021 / PubMed / Full text
Protein structural and mechanistic basis of progeroid laminopathies. / 16.08.2020 / PubMed / Full text
Progerin Expression Induces Inflammation, Oxidative Stress and Senescence in Human Coronary Endothelial Cells. / 12.05.2020 / PubMed / Full text
The JAK1/2 inhibitor ruxolitinib delays premature aging phenotypes. / 04.2020 / PubMed / Full text
Pharmacotherapy to gene editing: potential therapeutic approaches for Hutchinson-Gilford progeria syndrome. / 04.2020 / PubMed / Full text
Long term breeding of the Lmna G609G progeric mouse: Characterization of homozygous and heterozygous models. / 02.2020 / PubMed / Full text
Epigenetic signatures of Werner syndrome occur early in life and are distinct from normal epigenetic aging processes. / 10.2019 / PubMed / Full text
Transient introduction of human telomerase mRNA improves hallmarks of progeria cells. / 08.2019 / PubMed / Full text
A humanized yeast system to analyze cleavage of prelamin A by ZMPSTE24. / 15.03.2019 / PubMed / Full text
Impaired immune surveillance accelerates accumulation of senescent cells and aging. / 21.12.2018 / PubMed / Full text
Endothelial progerin expression causes cardiovascular pathology through an impaired mechanoresponse. / 01.02.2019 / PubMed / Full text
Targeting the phospholipase A2 receptor ameliorates premature aging phenotypes. / 12.2018 / PubMed / Full text
Altered modulation of lamin A/C-HDAC2 interaction and p21 expression during oxidative stress response in HGPS. / 10.2018 / PubMed / Full text
Cellular stress and AMPK activation as a common mechanism of action linking the effects of metformin and diverse compounds that alleviate accelerated aging defects in Hutchinson-Gilford progeria syndrome. / 09.2018 / PubMed / Full text
Proteomic changes during adult stage in pre-optic, hypothalamus, hippocampus and pituitary regions of female rat brain following neonatal exposure to estradiol-17β. / 15.09.2018 / PubMed / Full text
RECQ helicase disease and related progeroid syndromes: RECQ2018 meeting. / 07.2018 / PubMed / Full text
Upregulation of the aging related LMNA splice variant progerin in dilated cardiomyopathy. / 2018 / PubMed / Full text
Increasing autophagy and blocking Nrf2 suppress laminopathy-induced age-dependent cardiac dysfunction and shortened lifespan. / 06.2018 / PubMed / Full text
Lipodystrophic syndromes due to LMNA mutations: recent developments on biomolecular aspects, pathophysiological hypotheses and therapeutic perspectives. / 01.01.2018 / PubMed / Full text
Differential stem cell aging kinetics in Hutchinson-Gilford progeria syndrome and Werner syndrome. / 04.2018 / PubMed / Full text
Mandibuloacral dysplasia: A premature ageing disease with aspects of physiological ageing. / 03.2018 / PubMed / Full text

SHBG

Endogenous Testosterone Levels and the Risk of Incident Cardiovascular Events in Elderly Men: The MrOS Prospective Study. / 01.05.2020 / PubMed / Full text
Associations of Endogenous Sex Hormones with Carotid Plaque Burden and Characteristics in Midlife Women. / 01.04.2020 / PubMed / Full text
Analysis of the Relationship between the Levels of Androgens and Biochemical Bone Markers in Men Aged 60-75 Years. / 22.12.2019 / PubMed / Full text
Testosterone and Estrone Increase From the Age of 70 Years: Findings From the Sex Hormones in Older Women Study. / 01.12.2019 / PubMed / Full text
Aging and the Male Reproductive System. / 01.08.2019 / PubMed / Full text
Prospective associations of androgens and sex hormone-binding globulin with 12-month, lifetime and incident anxiety and depressive disorders in men and women from the general population. / 15.02.2019 / PubMed / Full text
Cross-sectional associations of sex hormones with leucocyte telomere length, a marker of biological age, in a community-based cohort of older men. / 04.2019 / PubMed / Full text
Testosterone level in aging male with different glucose tolerance state and its association with osteocalcin. / 03.2019 / PubMed / Full text
Inverse association of testosterone and sex hormone binding globulin levels with leukocyte count in middle-aged and elderly men. / 09.2018 / PubMed / Full text
[Vasectomy has no obvious longterm influence on the levels of serum androgens in aging males]. / 02.2017 / PubMed
GONADOPENIA AND AGING IN MEN. / 04.2018 / PubMed / Full text
Reassessing Free-Testosterone Calculation by Liquid Chromatography-Tandem Mass Spectrometry Direct Equilibrium Dialysis. / 01.06.2018 / PubMed / Full text
Plasma steroids, body composition, and fat distribution: effects of age, sex, and exercise training. / 07.2018 / PubMed / Full text
New determinants for gallstone disease? . / 02.2018 / PubMed
The effect of acute and chronic exercise on steroid hormone fluctuations in young and middle-aged men. / 04.2018 / PubMed / Full text
Effects of growth hormone administration on luteinizing hormone secretion in healthy older men and women. / 12.2017 / PubMed / Full text
Individual testosterone decline and future mortality risk in men. / 01.2018 / PubMed / Full text
Ageratum conyzoides L. inhibits 5-alpha-reductase gene expression in human prostate cells and reduces symptoms of benign prostatic hypertrophy in otherwise healthy men in a double blind randomized placebo controlled clinical study. / 11.2017 / PubMed / Full text
Evaluating Calculated Free Testosterone as a Predictor of Morbidity and Mortality Independent of Testosterone for Cross-sectional and 5-Year Longitudinal Health Outcomes in Older Men: The Concord Health and Ageing in Men Project. / 09.05.2018 / PubMed / Full text
Progressive impairment of testicular endocrine function in ageing men: Testosterone and dihydrotestosterone decrease, and luteinizing hormone increases, in men transitioning from the 8th to 9th decades of life. / 01.2018 / PubMed / Full text
The impact of age, BMI and sex hormone on aging males' symptoms and the international index of erectile function scores. / 12.2017 / PubMed / Full text

TP53

p53 inhibits the osteogenic differentiation but does not induce senescence in human dental follicle cells. / 07-08.2020 / PubMed / Full text
Mutational spectrum and dynamics of clonal hematopoiesis in anemia of older individuals. / 02.04.2020 / PubMed / Full text
TP53/miR-34a-associated signaling targets [i]SERPINE1[/i] expression in human pancreatic cancer. / 27.01.2020 / PubMed / Full text
Expression of p16 in nodular fasciitis: an implication for self-limited and inflammatory nature of the lesion. / 2019 / PubMed / Full text
Ultra-Sensitive TP53 Sequencing for Cancer Detection Reveals Progressive Clonal Selection in Normal Tissue over a Century of Human Lifespan. / 02.07.2019 / PubMed / Full text
Collaboration of MYC and RUNX2 in lymphoma simulates T-cell receptor signaling and attenuates p53 pathway activity. / 10.2019 / PubMed / Full text
mTOR Signaling Pathway Regulates Sperm Quality in Older Men. / 21.06.2019 / PubMed / Full text
[i]TP53[/i] Tumor-suppressor Gene Plays a Key Role in IGF1 Signaling Pathway Related to the Aging of Human Melanocytes. / 05.2019 / PubMed / Full text
Distinct cellular responses to replication stress leading to apoptosis or senescence. / 05.2019 / PubMed / Full text
Somatic genome alterations in relation to age in lung adenocarcinoma. / 15.10.2019 / PubMed / Full text
Predictors of disease aggressiveness influence outcome from immunotherapy treatment in renal clear cell carcinoma. / 2019 / PubMed / Full text
Adipose TSHB in Humans and Serum TSH in Hypothyroid Rats Inform About Cellular Senescence. / 2018 / PubMed / Full text
Breast cancer survival predicted by TP53 mutation status differs markedly depending on treatment. / 01.10.2018 / PubMed / Full text
Defective autophagy in vascular smooth muscle cells enhances cell death and atherosclerosis. / 2018 / PubMed / Full text
Detection of a novel, primate-specific 'kill switch' tumor suppression mechanism that may fundamentally control cancer risk in humans: an unexpected twist in the basic biology of TP53. / 11.2018 / PubMed / Full text
Human electronegative LDL induces mitochondrial dysfunction and premature senescence of vascular cells in vivo. / 08.2018 / PubMed / Full text
Troponin T3 associates with DNA consensus sequence that overlaps with p53 binding motifs. / 15.07.2018 / PubMed / Full text
The genetic component of human longevity: New insights from the analysis of pathway-based SNP-SNP interactions. / 06.2018 / PubMed / Full text
Identification of human age-associated gene co-expressions in functional modules using liquid association. / 02.01.2018 / PubMed / Full text
Genetic interrogation of replicative senescence uncovers a dual role for USP28 in coordinating the p53 and GATA4 branches of the senescence program. / 01.10.2017 / PubMed / Full text
A lowered 26S proteasome activity correlates with mantle lymphoma cell lines resistance to genotoxic stress. / 10.08.2017 / PubMed / Full text

ATR

Bloodstain age estimation through infrared spectroscopy and Chemometric models. / 11.2020 / PubMed / Full text
Artificial Intelligence and fourier-transform infrared spectroscopy for evaluating water-mediated degradation of lubricant oils. / 01.11.2020 / PubMed / Full text
Senescence Induction by Combined Ionizing Radiation and DNA Damage Response Inhibitors in Head and Neck Squamous Cell Carcinoma Cells. / 01.09.2020 / PubMed / Full text
Kinetics of thermal degradation and lifetime study of poly(vinylidene fluoride) (PVDF) subjected to bioethanol fuel accelerated aging. / 07.2020 / PubMed / Full text
Supraphysiological protection from replication stress does not extend mammalian lifespan. / 06.04.2020 / PubMed / Full text
Assessing the Retest Reliability of Prefrontal EEG Markers of Brain Rhythm Slowing in the Eyes-Closed Resting State. / 09.2020 / PubMed / Full text
Effects of Hydrogen Peroxide and Sodium Hypochlorite Aging on Properties and Performance of Polyethersulfone Ultrafiltration Membrane. / 18.10.2019 / PubMed / Full text
NF-κB signaling in skin aging. / 12.2019 / PubMed / Full text
Development of a w/o emulsion using ionic liquid strategy for transdermal delivery of anti - aging component α - lipoic acid: Mechanism of different ionic liquids on skin retention and efficacy evaluation. / 01.01.2020 / PubMed / Full text
Effect of Nitrogen-Doped Graphene Oxide on the Aging Behavior of Nitrile-Butadiene Rubber. / 10.10.2019 / PubMed / Full text
Age-related dysfunction of the DNA damage response in intestinal stem cells. / 2019 / PubMed / Full text
Age-related variations in corneal geometry and their association with astigmatism: The Yamagata Study (Funagata). / 10.2018 / PubMed / Full text
Sex-related differences in corneal astigmatism and shape with age. / 09.2018 / PubMed / Full text
Aging-Resistant Functionalized LDH⁻SAS/Nitrile-Butadiene Rubber Composites: Preparation and Study of Aging Kinetics/Anti-Aging Mechanism. / 18.05.2018 / PubMed / Full text
[Protective effect of Wuzi Yanzong recipe on testicular DNA damage and apoptosis in natural ageing rats]. / 04.2018 / PubMed / Full text
Age-related changes in with-the-rule and oblique corneal astigmatism. / 09.2018 / PubMed / Full text
Investigation of the factors that influence lead accumulation onto polyethylene: Implication for potable water plumbing pipes. / 05.04.2018 / PubMed / Full text
Global mapping of transcription factor motifs in human aging. / 2018 / PubMed / Full text
Cross-Sectional and Longitudinal Investigation of the Power Vector in Astigmatism: The Yamagata Study (Funagata). / 01.2018 / PubMed / Full text
Glomerular and tubular effects of nitric oxide (NO) are regulated by angiotensin II (Ang II) in an age-dependent manner through activation of both angiotensin receptors (AT1Rs and AT2Rs) in conscious lambs. / 02.2018 / PubMed / Full text

LPA

Ginseng gintonin, aging societies, and geriatric brain diseases. / 03.2021 / PubMed / Full text
Late-life related subtypes of depression - a data-driven approach on cognitive domains and physical frailty. / 22.05.2020 / PubMed / Full text
Does sedentary time increase in older adults in the days following participation in intense exercise? / 12.2020 / PubMed / Full text
Association of Long-term Exposure to Elevated Lipoprotein(a) Levels With Parental Life Span, Chronic Disease-Free Survival, and Mortality Risk: A Mendelian Randomization Analysis. / 05.02.2020 / PubMed / Full text
Elevated Autotaxin and LPA Levels During Chronic Viral Hepatitis and Hepatocellular Carcinoma Associate with Systemic Immune Activation. / 25.11.2019 / PubMed / Full text
Lysophosphatidic acid receptor LPA prevents oxidative stress and cellular senescence in Hutchinson-Gilford progeria syndrome. / 01.2020 / PubMed / Full text
Associations of Sedentary and Physically-Active Behaviors With Cognitive-Function Decline in Community-Dwelling Older Adults: Compositional Data Analysis From the NEIGE Study. / 05.11.2020 / PubMed / Full text
Validation and comparison of two automated methods for quantifying brain white matter hyperintensities of presumed vascular origin. / 02.2020 / PubMed / Full text
The Sedentary Time and Physical Activity Levels on Physical Fitness in the Elderly: A Comparative Cross Sectional Study. / 01.10.2019 / PubMed / Full text
Light-Intensity Physical Activity in a Large Prospective Cohort of Older US Adults: A 21-Year Follow-Up of Mortality. / 2020 / PubMed / Full text
The Impact of Movement Behaviors on Bone Health in Elderly with Adequate Nutritional Status: Compositional Data Analysis Depending on the Frailty Status. / 09.03.2019 / PubMed / Full text
Compositional Influence of Movement Behaviors on Bone Health during Aging. / 08.2019 / PubMed / Full text
Duration-Response of Light-Intensity Physical Activity and Glucose Dynamics in Older Adults. / 01.01.2019 / PubMed / Full text
Accelerometer-Measured Physical Activity and Sedentary Behavior: A Cross-Sectional Study of Brazilian Older Adults. / 01.11.2018 / PubMed / Full text
The Association Between Physical Activity, Including Physical Activity Intensity, and Fear of Falling Differs by Fear Severity in Older Adults Living in the Community. / 16.04.2020 / PubMed / Full text
Gintonin Attenuates D-Galactose-Induced Hippocampal Senescence by Improving Long-Term Hippocampal Potentiation, Neurogenesis, and Cognitive Functions. / 2018 / PubMed / Full text
Associations of distinct levels of physical activity with mobility in independent healthy older women. / 09.2018 / PubMed / Full text
Reallocating Accelerometer-Assessed Sedentary Time to Light or Moderate- to Vigorous-Intensity Physical Activity Reduces Frailty Levels in Older Adults: An Isotemporal Substitution Approach in the TSHA Study. / 02.2018 / PubMed / Full text
Lean psoas area does not correlate with clinical outcomes in moderately to severely injured older people. / 03.2018 / PubMed / Full text
Genome-wide meta-analysis associates HLA-DQA1/DRB1 and LPA and lifestyle factors with human longevity. / 13.10.2017 / PubMed / Full text

CD27

The Interplay between CD27 and CD27 B Cells Ensures the Flexibility, Stability, and Resilience of Human B Cell Memory. / 03.03.2020 / PubMed / Full text
CMV-independent increase in CD27-CD28+ CD8+ EMRA T cells is inversely related to mortality in octogenarians. / 2020 / PubMed / Full text
Compartmentalized cytotoxic immune response leads to distinct pathogenic roles of natural killer and senescent CD8 T cells in human cutaneous leishmaniasis. / 04.2020 / PubMed / Full text
CD27- IgD- B cell memory subset associates with inflammation and frailty in elderly individuals but only in males. / 2019 / PubMed / Full text
Are skin senescence and immunosenescence linked within individuals? / 08.2019 / PubMed / Full text
Circulating Senescent T Cells Are Linked to Systemic Inflammation and Lesion Size During Human Cutaneous Leishmaniasis. / 2018 / PubMed / Full text
Low IL-2 Expressing T Cells in Thalassemia Major Patients: Is It Immune Aging. / 10.2018 / PubMed / Full text
Senescence markers: Predictive for response to checkpoint inhibitors. / 01.03.2019 / PubMed / Full text
Features of Immunosenescence in Women Newly Diagnosed With Breast Cancer. / 2018 / PubMed / Full text
Age, calorie restriction, and age of calorie restriction onset reduce maturation of natural killer cells in C57Bl/6 mice. / 07.2018 / PubMed / Full text
CD57 identifies T cells with functional senescence before terminal differentiation and relative telomere shortening in patients with activated PI3 kinase delta syndrome. / 11.2018 / PubMed / Full text
An immunological age index in bipolar disorder: A confirmatory factor analysis of putative immunosenescence markers and associations with clinical characteristics. / 12.2018 / PubMed / Full text
Age-associated distribution of normal B-cell and plasma cell subsets in peripheral blood. / 06.2018 / PubMed / Full text
Diminished antibody response to influenza vaccination is characterized by expansion of an age-associated B-cell population with low PAX5. / 08.2018 / PubMed / Full text
Dynamics of CD4 and CD8 T-Cell Subsets and Inflammatory Biomarkers during Early and Chronic HIV Infection in Mozambican Adults. / 2017 / PubMed / Full text
Genetic influence on splenic natural killer cell frequencies and maturation among aged mice. / 04.2018 / PubMed / Full text
Increased senescent CD8+ T cells in the peripheral blood mononuclear cells of Behçet's disease patients. / 03.2018 / PubMed / Full text
T-cell differentiation and CD56+ levels in polypoidal choroidal vasculopathy and neovascular age-related macular degeneration. / 20.11.2017 / PubMed / Full text
Human CD8 EMRA T cells display a senescence-associated secretory phenotype regulated by p38 MAPK. / 02.2018 / PubMed / Full text

EGF

Acute, exercise-induced alterations in cytokines and chemokines in the blood distinguish physically active and sedentary aging. / 08.12.2020 / PubMed / Full text
Proinflammation, profibrosis, and arterial aging. / 09.2020 / PubMed / Full text
Hinokitiol induces cell death and inhibits epidermal growth factor-induced cell migration and signaling pathways in human cervical adenocarcinoma. / 09.2020 / PubMed / Full text
Activation of epidermal growth factor receptor signaling mediates cellular senescence induced by certain pro-inflammatory cytokines. / 05.2020 / PubMed / Full text
Insulin Signaling in Intestinal Stem and Progenitor Cells as an Important Determinant of Physiological and Metabolic Traits in [i]Drosophila[/i]. / 26.03.2020 / PubMed / Full text
Different cellular properties and loss of nuclear signalling of porcine epidermal growth factor receptor with aging. / 01.05.2020 / PubMed / Full text
Isoform-selective as opposed to complete depletion of fibroblast growth factor 2 (FGF-2) has no major impact on survival and gene expression in SOD1 amyotrophic lateral sclerosis mice. / 09.2019 / PubMed / Full text
A novel age-related venous amyloidosis derived from EGF-containing fibulin-like extracellular matrix protein 1. / 04.2019 / PubMed / Full text
EGF/EGFR upregulates and cooperates with Netrin-4 to protect glioblastoma cells from DNA damage-induced senescence. / 04.12.2018 / PubMed / Full text
Circulating Vascular Growth Factors and Magnetic Resonance Imaging Markers of Small Vessel Disease and Atrophy in Middle-Aged Adults. / 09.2018 / PubMed / Full text
The effects of aging, diabetes mellitus, and antiplatelet drugs on growth factors and anti-aging proteins in platelet-rich plasma. / 2019 / PubMed / Full text
Insulin-like growth factor-1 acts as a zeitgeber on hypothalamic circadian clock gene expression via glycogen synthase kinase-3β signaling. / 02.11.2018 / PubMed / Full text
Burn wounds in the young versus the aged patient display differential immunological responses. / 09.2018 / PubMed / Full text
Precise Intradermal Injection of Nanofat-Derived Stromal Cells Combined with Platelet-Rich Fibrin Improves the Efficacy of Facial Skin Rejuvenation. / 2018 / PubMed / Full text
RPE phagocytic function declines in age-related macular degeneration and is rescued by human umbilical tissue derived cells. / 13.03.2018 / PubMed / Full text
Human amniotic mesenchymal stem cells improve ovarian function in natural aging through secreting hepatocyte growth factor and epidermal growth factor. / 09.03.2018 / PubMed / Full text
VEGF Signaling in Neurological Disorders. / 17.01.2018 / PubMed / Full text
Global analysis of gene expression profiles in the submandibular salivary gland of klotho knockout mice. / 04.2018 / PubMed / Full text
Multilayered Reprogramming in Response to Persistent DNA Damage in C. elegans. / 29.08.2017 / PubMed / Full text

F2

Environmental risk assessment of glufosinate-resistant soybean by pollen-mediated gene flow under field conditions in the region of the genetic origin. / 17.10.2020 / PubMed / Full text
Gestational arsenite exposure augments hepatic tumors of C3H mice by promoting senescence in F1 and F2 offspring via different pathways. / 01.12.2020 / PubMed / Full text
Familial Longevity is Associated with an Attenuated Thyroidal Response to Recombinant Human Thyroid Stimulating Hormone. / 01.07.2020 / PubMed / Full text
Conclusions from a behavioral aging study on male and female F2 hybrid mice on age-related behavior, buoyancy in water-based tests, and an ethical method to assess lifespan. / 11.09.2019 / PubMed / Full text
In utero exposure to acetaminophen and ibuprofen leads to intergenerational accelerated reproductive aging in female mice. / 2019 / PubMed / Full text
Mitochondrial DNA alterations in aged macrophage migration inhibitory factor-knockout mice. / 09.2019 / PubMed / Full text
Effect of zirconia surface treatment, resin cement and aging on the load-bearing capacity under fatigue of thin simplified full-contour Y-TZP restorations. / 09.2019 / PubMed / Full text
Maternal Resveratrol Supplementation Prevents Cognitive Decline in Senescent Mice Offspring. / 06.03.2019 / PubMed / Full text
Transgenerational hormetic effects of sublethal dose of flupyradifurone on the green peach aphid, Myzus persicae (Sulzer) (Hemiptera: Aphididae). / 2019 / PubMed / Full text
Early treatment of acute hepatitis C infection is cost-effective in HIV-infected men-who-have-sex-with-men. / 2019 / PubMed / Full text
Adult rat morphine exposure changes morphine preference, anxiety, and the brain expression of dopamine receptors in male offspring. / 10.2018 / PubMed / Full text
Age-related changes in shock absorption capacity of the human spinal column. / 2018 / PubMed / Full text
Influence of Supplemental Protein on the Life Expectancy and Reproduction of the Chinese Citrus Fruit Fly, Bactrocera minax (Enderlein) (Tetradacus minax) (Diptera: Tephritidae). / 01.03.2018 / PubMed / Full text
Effect of Cold Storage on Biological Traits of Psix saccharicola (Hymenoptera: Platygastridae), an Egg Parasitoid of Acrosternum arabicum (Hemiptera: Pentatomidae). / 28.05.2018 / PubMed / Full text
Short-Term Genetic Selection for Adolescent Locomotor Sensitivity to Delta9-Tetrahydrocannabinol (THC). / 05.2018 / PubMed / Full text
Early-life exposure to three size-fractionated ultrafine and fine atmospheric particulates in Beijing exacerbates asthma development in mature mice. / 14.03.2018 / PubMed / Full text
F2-Isoprostanes Reflect Oxidative Stress Correlated With Lean Mass and Bone Density but Not Insulin Resistance. / 01.05.2017 / PubMed / Full text
Multigenerational effects of 4-methylbenzylidene camphor (4-MBC) on the survival, development and reproduction of the marine copepod Tigriopus japonicus. / 01.2018 / PubMed / Full text
Effects of Aging on Vocal Fundamental Frequency and Vowel Formants in Men and Women. / 09.2018 / PubMed / Full text

NHS

Telomerase Activation to Reverse Immunosenescence in Elderly Patients With Acute Coronary Syndrome: Protocol for a Randomized Pilot Trial. / 23.09.2020 / PubMed / Full text
Factors associated with COVID-19-related death using OpenSAFELY. / 08.2020 / PubMed / Full text
Advanced ophthalmic nurse practitioners: the potential to improve outcomes for older people with cataracts. / 17.06.2020 / PubMed / Full text
Patient Satisfaction in the Spanish National Health Service: Partial Least Squares Structural Equation Modeling. / 04.12.2019 / PubMed / Full text
Heart failure with preserved ejection fraction (HFpEF) pathophysiology study (IDENTIFY-HF): does increased arterial stiffness associate with HFpEF, in addition to ageing and vascular effects of comorbidities? Rationale and design. / 19.11.2019 / PubMed / Full text
Challenges to concordance: theories that explain variations in patient responses. / 02.10.2019 / PubMed / Full text
Optimism is associated with exceptional longevity in 2 epidemiologic cohorts of men and women. / 10.09.2019 / PubMed / Full text
Reducing readmission rates through a discharge follow-up service. / 06.2019 / PubMed / Full text
The cost burden of falls in people with glaucoma in National Health Service Hospital Trusts in the UK. / 01.2020 / PubMed / Full text
How Do General Practitioners (GPs) Engage in Falls Prevention With Older People? A Pilot Survey of GPs in NHS England Suggests a Gap in Routine Practice to Address Falls Prevention. / 2019 / PubMed / Full text
Fruit and vegetable consumption, cigarette smoke, and leukocyte mitochondrial DNA copy number. / 01.02.2019 / PubMed / Full text
Where are we now in perioperative medicine? Results from a repeated UK survey of geriatric medicine delivered services for older people. / 01.05.2019 / PubMed / Full text
PATCH: posture and mobility training for care staff versus usual care in care homes: study protocol for a randomised controlled trial. / 24.09.2018 / PubMed / Full text
Predictive model of length of stay in hospital among older patients. / 07.2019 / PubMed / Full text
A qualitative study of the determinants of adherence to NICE falls guideline in managing older fallers attending an emergency department. / 18.07.2018 / PubMed / Full text
Economic evaluations of eHealth technologies: A systematic review. / 2018 / PubMed / Full text
Shifting to triple value healthcare: Reflections from England. / 02.2018 / PubMed / Full text
Is "end of life" a special case? Connecting Q with survey methods to measure societal support for views on the value of life-extending treatments. / 05.2018 / PubMed / Full text
PERFECTED enhanced recovery (PERFECT-ER) care versus standard acute care for patients admitted to acute settings with hip fracture identified as experiencing confusion: study protocol for a feasibility cluster randomized controlled trial. / 04.12.2017 / PubMed / Full text

WRN

The Impact of Vitamin C on Different System Models of Werner Syndrome. / 17.11.2020 / PubMed / Full text
WRN modulates translation by influencing nuclear mRNA export in HeLa cancer cells. / 14.10.2020 / PubMed / Full text
MIB1-mediated degradation of WRN promotes cellular senescence in response to camptothecin treatment. / 09.2020 / PubMed / Full text
A Case Report of Werner's Syndrome With a Novel Mutation From India. / 08.05.2020 / PubMed / Full text
Evidence for premature aging in a Drosophila model of Werner syndrome. / 11.2019 / PubMed / Full text
Epigenetic signatures of Werner syndrome occur early in life and are distinct from normal epigenetic aging processes. / 10.2019 / PubMed / Full text
Studying Werner syndrome to elucidate mechanisms and therapeutics of human aging and age-related diseases. / 06.2019 / PubMed / Full text
Werner Syndrome Protein and DNA Replication. / 02.11.2018 / PubMed / Full text
A case report of Werner's syndrome with bilateral juvenile cataracts. / 14.08.2018 / PubMed / Full text
Genomic instability and DNA replication defects in progeroid syndromes. / 31.12.2018 / PubMed / Full text
Nonfunctional mutant Wrn protein leads to neurological deficits, neuronal stress, microglial alteration, and immune imbalance in a mouse model of Werner syndrome. / 10.2018 / PubMed / Full text
Acidic domain of WRNp is critical for autophagy and up-regulates age associated proteins. / 08.2018 / PubMed / Full text
RECQ helicase disease and related progeroid syndromes: RECQ2018 meeting. / 07.2018 / PubMed / Full text
Differential stem cell aging kinetics in Hutchinson-Gilford progeria syndrome and Werner syndrome. / 04.2018 / PubMed / Full text
Serum vitamin C levels modulate the lifespan and endoplasmic reticulum stress response pathways in mice synthesizing a nonfunctional mutant WRN protein. / 07.2018 / PubMed / Full text
Werner syndrome (WRN) gene variants and their association with altered function and age-associated diseases. / 01.2018 / PubMed / Full text
Human RecQL4 helicase plays multifaceted roles in the genomic stability of normal and cancer cells. / 28.01.2018 / PubMed / Full text
Recent Advances in Understanding Werner Syndrome. / 2017 / PubMed / Full text
Systematic analysis of DNA crosslink repair pathways during development and aging in Caenorhabditis elegans. / 19.09.2017 / PubMed / Full text

CD14

Human innate immune cell crosstalk induces melanoma cell senescence. / 30.08.2020 / PubMed / Full text
Fusion Potential of Human Osteoclasts In Vitro Reflects Age, Menopause, and In Vivo Bone Resorption Levels of Their Donors-A Possible Involvement of DC-STAMP. / 02.09.2020 / PubMed / Full text
Association of CD14 with incident dementia and markers of brain aging and injury. / 21.01.2020 / PubMed / Full text
Compromised Bone Healing in Aged Rats Is Associated With Impaired M2 Macrophage Function. / 2019 / PubMed / Full text
Adipose-Derived Stem/Stromal Cells Recapitulate Aging Biomarkers and Show Reduced Stem Cell Plasticity Affecting Their Adipogenic Differentiation Capacity. / 08.2019 / PubMed / Full text
Increased monocyte activation with age among HIV-infected long term non-progressor children: implications for early treatment initiation. / 09.2019 / PubMed / Full text
Wheat seed ageing viewed through the cellular redox environment and changes in pH. / 06.2019 / PubMed / Full text
Senescent Phenotype Induced by p90RSK-NRF2 Signaling Sensitizes Monocytes and Macrophages to Oxidative Stress in HIV-Positive Individuals. / 26.02.2019 / PubMed / Full text
Effects of pepsin and pepstatin on reflux tonsil hypertrophy in vitro. / 2018 / PubMed / Full text
Innate and adaptive immune dysregulation in critically ill ICU patients. / 05.07.2018 / PubMed / Full text
Serum Zonulin and Endotoxin Levels in Exceptional Longevity versus Precocious Myocardial Infarction. / 04.2018 / PubMed / Full text
Rapid Turnover and High Production Rate of Myeloid Cells in Adult Rhesus Macaques with Compensations during Aging. / 15.06.2018 / PubMed / Full text
Human colostrum action against Giardia lamblia infection influenced by hormones and advanced maternal age. / 06.2018 / PubMed / Full text
The pro-inflammatory phenotype of the human non-classical monocyte subset is attributed to senescence. / 15.02.2018 / PubMed / Full text
Aged Chinese-origin rhesus macaques infected with SIV develop marked viremia in absence of clinical disease, inflammation or cognitive impairment. / 01.02.2018 / PubMed / Full text
Stem Cells and Progenitors in Human Peripheral Blood Get Activated by Extremely Active Resveratrol (XAR™). / 04.2018 / PubMed / Full text
Acute Effects of Nitrate-Rich Beetroot Juice on Blood Pressure, Hemostasis and Vascular Inflammation Markers in Healthy Older Adults: A Randomized, Placebo-Controlled Crossover Study. / 22.11.2017 / PubMed / Full text
Proteomic profiling of follicle fluids after superstimulation in one-month-old lambs. / 02.2018 / PubMed / Full text

LBP

Lipopolysaccharide binding protein is associated with CVD risk in older adults. / 08.09.2020 / PubMed / Full text
Aging-related liver degeneration is associated with increased bacterial endotoxin and lipopolysaccharide binding protein levels. / 01.04.2020 / PubMed / Full text
Biomarkers of leaky gut are related to inflammation and reduced physical function in older adults with cardiometabolic disease and mobility limitations. / 12.2019 / PubMed / Full text
Needle-shaped amyloid deposition in rat mammary gland: evidence of a novel amyloid fibril protein. / 03.2020 / PubMed / Full text
Effects of Lycium barbarum Polysaccharides on Health and Aging of [i]C. elegans[/i] Depend on [i]daf-12/daf-16[/i]. / 2019 / PubMed / Full text
Structural characterization of life-extending Caenorhabditis elegans Lipid Binding Protein 8. / 10.07.2019 / PubMed / Full text
Lycium barbarum polysaccharides extend the mean lifespan of Drosophila melanogaster. / 17.07.2019 / PubMed / Full text
Height loss but not body composition is related to low back pain in community-dwelling elderlies: Shimane CoHRE study. / 10.05.2019 / PubMed / Full text
Aging of mouse intervertebral disc and association with back pain. / 06.2019 / PubMed / Full text
A comparison of the mitochondrial proteome and lipidome in the mouse and long-lived Pipistrelle bats. / 19.03.2019 / PubMed / Full text
Chen-Style Tai Chi for Individuals (Aged 50 Years Old or Above) with Chronic Non-Specific Low Back Pain: A Randomized Controlled Trial. / 12.02.2019 / PubMed / Full text
Lysosomal Signaling Promotes Longevity by Adjusting Mitochondrial Activity. / 11.03.2019 / PubMed / Full text
Factors associated with lumbar disc high-intensity zone (HIZ) on T2-weighted magnetic resonance image: a retrospective study of 3185 discs in 637 patients. / 04.12.2018 / PubMed / Full text
Urolithin A Inhibits the Catabolic Effect of TNFα on Nucleus Pulposus Cell and Alleviates Intervertebral Disc Degeneration [i]in vivo[/i]. / 2018 / PubMed / Full text
Use of trunk muscle training and neuromuscular electrical stimulation to reduce pain and disability in an older adult with chronic low back pain: A case report. / 08.2019 / PubMed / Full text
Endotoxemia is modulated by quantity and quality of dietary fat in older adults. / 08.2018 / PubMed / Full text
Correlates of a Recent History of Disabling Low Back Pain in Community-dwelling Older Persons: The Pain in the Elderly (PAINEL) Study. / 06.2018 / PubMed / Full text
The Effectiveness and Safety of Manual Therapy on Pain and Disability in Older Persons With Chronic Low Back Pain: A Systematic Review. / 09.2017 / PubMed / Full text

NGF

Dietary fish hydrolysate supplementation containing n-3 LC-PUFAs and peptides prevents short-term memory and stress response deficits in aged mice. / 23.09.2020 / PubMed / Full text
Imbalance of nerve growth factor metabolism in aging women with overactive bladder syndrome. / 01.09.2020 / PubMed / Full text
Parity Attenuates Intraepithelial Corneal Sensory Nerve Loss in Female Mice. / 21.07.2020 / PubMed / Full text
Cholinergic System and NGF Receptors: Insights from the Brain of the Short-Lived Fish [i]Nothobranchius furzeri[/i]. / 20.06.2020 / PubMed / Full text
Retrograde axonal transport of BDNF and proNGF diminishes with age in basal forebrain cholinergic neurons. / 12.2019 / PubMed / Full text
C-SH2 point mutation converts p85β regulatory subunit of phosphoinositide 3-kinase to an anti-aging gene. / 03.09.2019 / PubMed / Full text
[i]Hericium erinaceus[/i] Mycelium and Its Isolated Compound, Erinacine A, Ameliorate High-Fat High-Sucrose Diet-Induced Metabolic Dysfunction and Spatial Learning Deficits in Aging Mice. / 05.2019 / PubMed / Full text
Morphological and immunohistochemical characteristics of the equine corneal epithelium. / 11.2019 / PubMed / Full text
Ectopic nerve growth factor prevents proliferation in glioma cells by senescence induction. / 05.2019 / PubMed / Full text
Mechanisms Underlying the Regulation of HP1γ by the NGF-PKA Signaling Pathway. / 10.10.2018 / PubMed / Full text
Insulin-like growth factor-1 acts as a zeitgeber on hypothalamic circadian clock gene expression via glycogen synthase kinase-3β signaling. / 02.11.2018 / PubMed / Full text
Nasal delivery of nerve growth factor rescue hypogonadism by up-regulating GnRH and testosterone in aging male mice. / 09.2018 / PubMed / Full text
Evidence for changing nerve growth factor signalling mechanisms during development, maturation and ageing in the rat molar pulp. / 02.2019 / PubMed / Full text
Reduced NGF in Gastric Endothelial Cells Is One of the Main Causes of Impaired Angiogenesis in Aging Gastric Mucosa. / 2018 / PubMed / Full text
Anti-nerve growth factor does not change physical activity in normal young or aging mice but does increase activity in mice with skeletal pain. / 11.2018 / PubMed / Full text
Effects of cerebrolysin on nerve growth factor system in the aging rat brain. / 2017 / PubMed / Full text
Immunohistochemical localization of nerve growth factor, tropomyosin receptor kinase A, and p75 in the bone and articular cartilage of the mouse femur. / 01-12.2017 / PubMed / Full text
Differential deregulation of NGF and BDNF neurotrophins in a transgenic rat model of Alzheimer's disease. / 12.2017 / PubMed / Full text

SDS

Semiautomatic morphometric analysis of skeletal muscle obtained by needle biopsy in older adults. / 12.2020 / PubMed / Full text
Effects of late-onset dietary intake of salidroside on insulin/insulin-like growth factor-1 (IGF-1) signaling pathway of the annual fish Nothobranchius guentheri. / 17.08.2020 / PubMed / Full text
Quantification of Insoluble Protein Aggregation in Caenorhabditis elegans during Aging with a Novel Data-Independent Acquisition Workflow. / 07.08.2020 / PubMed / Full text
Skeletal Muscle Myofibrillar Protein Abundance Is Higher in Resistance-Trained Men, and Aging in the Absence of Training May Have an Opposite Effect. / 10.01.2020 / PubMed / Full text
Characterization, evaluation of nutritional parameters of Radix isatidis protein and its antioxidant activity in D-galactose induced ageing mice. / 06.11.2019 / PubMed / Full text
[Effects of silver nanoparticles on pupation, eclosion, life span, apoptosis and protein expression in Drosophila melanogaster]. / 10.2019 / PubMed / Full text
Does an Age-Specific Treatment Program Augment the Efficacy of a Cognitive-Behavioral Weight Loss Program in Adolescence and Young Adulthood? Results from a Controlled Study. / 02.09.2019 / PubMed / Full text
Strengths and limitations of Bacillus thuringiensis galleriae for managing Japanese beetle (Popillia japonica) adults and grubs with caveats for cross-order activity to monarch butterfly (Danaus plexippus) larvae. / 02.2020 / PubMed / Full text
3-Hydroxykynurenine bound to eye lens proteins induces oxidative modifications in crystalline proteins through a type I photosensitizing mechanism. / 09.2019 / PubMed / Full text
Recombinant Buckwheat Trypsin Inhibitor Improves the Protein and Mitochondria Homeostasis in Caenorhabditis elegans Model of Aging and Age-Related Disease. / 2019 / PubMed / Full text
Potential pitfalls in analyzing structural uncoupling of eNOS: aging is not associated with increased enzyme monomerization. / 01.01.2019 / PubMed / Full text
A 2-year longitudinal study of the relationship between masticatory function and progression to frailty or pre-frailty among community-dwelling Japanese aged 65 and older. / 11.2018 / PubMed / Full text
New findings on SNP variants of human protein L-isoaspartyl methyltransferase that affect catalytic activity, thermal stability, and aggregation. / 2018 / PubMed / Full text
Striatal Mutant Huntingtin Protein Levels Decline with Age in Homozygous Huntington's Disease Knock-In Mouse Models. / 2018 / PubMed / Full text
Proteomic changes during adult stage in pre-optic, hypothalamus, hippocampus and pituitary regions of female rat brain following neonatal exposure to estradiol-17β. / 15.09.2018 / PubMed / Full text
Cheap labor: myosin fiber type expression and enzyme activity in the forelimb musculature of sloths (Pilosa: Xenarthra). / 01.09.2018 / PubMed / Full text
Psychometric Evaluation of the Symptoms of Dementia Screener (SDS) in a Geriatric Primary Care Population. / 10-12.2019 / PubMed / Full text
The Aggravation of Depression with Aging in Japanese Patients with Subacute Myelo-optico-neuropathy (SMON). / 15.08.2017 / PubMed / Full text

ARC

The Polymorphism rs2968 of [i]LSS[/i] Gene Confers Susceptibility to Age-Related Cataract. / 11.2020 / PubMed / Full text
Decreased Anti-Müllerian hormone and Anti-Müllerian hormone receptor type 2 in hypothalami of old Japanese Black cows. / 19.08.2020 / PubMed / Full text
Resveratrol delay the cataract formation against naphthalene-induced experimental cataract in the albino rats. / 01.2020 / PubMed / Full text
lncRNA H19 contributes to oxidative damage repair in the early age-related cataract by regulating miR-29a/TDG axis. / 09.2019 / PubMed / Full text
Laminin α4 overexpression in the anterior lens capsule may contribute to the senescence of human lens epithelial cells in age-related cataract. / 10.05.2019 / PubMed / Full text
Dietary vitamin and carotenoid intake and risk of age-related cataract. / 01.01.2019 / PubMed / Full text
The impact of GJA8 SNPs on susceptibility to age-related cataract. / 12.2018 / PubMed / Full text
MicroRNA binding mediated Functional sequence variant in 3'-UTR of DNA repair Gene XPC in Age-related Cataract. / 12.10.2018 / PubMed / Full text
Serum selenium levels are associated with age-related cataract. / 25.09.2018 / PubMed / Full text
Chronic treatment with tributyltin induces sexually dimorphic alterations in the hypothalamic POMC system of adult mice. / 12.2018 / PubMed / Full text
Exercise Training Protects Against Aging-Induced Cognitive Dysfunction via Activation of the Hippocampal PGC-1α/FNDC5/BDNF Pathway. / 09.2018 / PubMed / Full text
miRNA Long-Term Response to Early Metabolic Environmental Challenge in Hypothalamic Arcuate Nucleus. / 2018 / PubMed / Full text
β-amyloid expression in age-related cataract lens epithelia and the effect of β-amyloid on oxidative damage in human lens epithelial cells. / 2017 / PubMed / Full text
17α-estradiol acts through hypothalamic pro-opiomelanocortin expressing neurons to reduce feeding behavior. / 02.2018 / PubMed / Full text
The effect of ARC ablation on skeletal muscle morphology, function, and apoptotic signaling during aging. / 01.2018 / PubMed / Full text
High-throughput sequencing reveals novel lincRNA in age-related cataract. / 12.2017 / PubMed / Full text
From bench (laboratory) to bed (hospital/home): How to explore effective natural and synthetic PAK1-blockers/longevity-promoters for cancer therapy. / 15.12.2017 / PubMed / Full text

MYC

Enhanced proliferative capacity of human preadipocytes achieved by an optimized cultivating method that induces transient activity of hTERT. / 20.08.2020 / PubMed / Full text
Collaboration of MYC and RUNX2 in lymphoma simulates T-cell receptor signaling and attenuates p53 pathway activity. / 10.2019 / PubMed / Full text
Regulation of RhoB Gene Expression during Tumorigenesis and Aging Process and Its Potential Applications in These Processes. / 13.06.2019 / PubMed / Full text
Transcriptomic analysis of human IL-7 receptor alpha and effector memory CD8 T cells reveals an age-associated signature linked to influenza vaccine response in older adults. / 08.2019 / PubMed / Full text
SLC1A5 glutamine transporter is a target of MYC and mediates reduced mTORC1 signaling and increased fatty acid oxidation in long-lived Myc hypomorphic mice. / 06.2019 / PubMed / Full text
Profound, durable and MGMT-independent sensitivity of glioblastoma cells to cyclin-dependent kinase inhibition. / 01.07.2019 / PubMed / Full text
MYC and RAS are unable to cooperate in overcoming cellular senescence and apoptosis in normal human fibroblasts. / 2018 / PubMed / Full text
A stably self-renewing adult blood-derived induced neural stem cell exhibiting patternability and epigenetic rejuvenation. / 02.10.2018 / PubMed / Full text
O-GlcNAcylation is required for mutant KRAS-induced lung tumorigenesis. / 01.11.2018 / PubMed / Full text
Centenarians Overexpress Pluripotency-Related Genes. / 16.08.2019 / PubMed / Full text
E47 Governs the MYC-CDKN1B/p27 -RB Network to Growth Arrest PDA Cells Independent of CDKN2A/p16 and Wild-Type p53. / 2018 / PubMed / Full text
Integrative Analysis of Hippocampus Gene Expression Profiles Identifies Network Alterations in Aging and Alzheimer's Disease. / 2018 / PubMed / Full text
MYC Releases Early Reprogrammed Human Cells from Proliferation Pause via Retinoblastoma Protein Inhibition. / 10.04.2018 / PubMed / Full text
Regulation of Cellular Senescence by Polycomb Chromatin Modifiers through Distinct DNA Damage- and Histone Methylation-Dependent Pathways. / 27.03.2018 / PubMed / Full text
Metformin regulates metabolic and nonmetabolic pathways in skeletal muscle and subcutaneous adipose tissues of older adults. / 04.2018 / PubMed / Full text
Modulation of dietary folate with age confers selective hepatocellular epigenetic imprints through DNA methylation. / 03.2018 / PubMed / Full text
Proline Metabolism in Cell Regulation and Cancer Biology: Recent Advances and Hypotheses. / 01.02.2019 / PubMed / Full text

STS

Delayed Impairment of Postural, Physical, and Muscular Functions Following Downhill Compared to Level Walking in Older People. / 2020 / PubMed / Full text
Autophagy displays divergent roles during intermittent amino acid starvation and toxic stress-induced senescence in cultured skeletal muscle cells. / 06.10.2020 / PubMed / Full text
The WRKY53 transcription factor enhances stilbene synthesis and disease resistance by interacting with MYB14 and MYB15 in Chinese wild grape. / 30.05.2020 / PubMed / Full text
On the role of ageing and musculoskeletal pain on dynamic balance in manual workers. / 02.2020 / PubMed / Full text
30-day mortality in frail patients undergoing cardiac surgery: the results of the [i]frailty in cardiac surgery (FICS) copenhagen study[/i]. / 12.2019 / PubMed / Full text
Chronic Fish Oil Consumption with Resistance Training Improves Grip Strength, Physical Function, and Blood Pressure in Community-Dwelling Older Adults. / 09.07.2019 / PubMed / Full text
Effects of Tai Chi versus Taekkyon on balance, lower-extremity strength, and gait ability in community-dwelling older women: A single-blinded randomized clinical trial. / 2020 / PubMed / Full text
Short-term starvation stress at young adult stages enhances meiotic activity of germ cells to maintain spermatogenesis in aged male Caenorhabditis elegans. / 06.2019 / PubMed / Full text
Flexibility in joint coordination remains unaffected by force and balance demands in young and old adults during simple sit-to-stand tasks. / 02.2019 / PubMed / Full text
The influence of knee extensor fatigue on lower extremity muscle activity during chair rise in young and older adults. / 01.2019 / PubMed / Full text
The sit-to-stand muscle power test: An easy, inexpensive and portable procedure to assess muscle power in older people. / 02.10.2018 / PubMed / Full text
Visual-Vestibular Interaction for Postural Control During Sit-to-Stand: Effects of Aging. / 01.01.2019 / PubMed / Full text
From Intervention to Co-constitution: New Directions in Theorizing about Aging and Technology. / 09.01.2019 / PubMed / Full text
Age-related Changes in Postural Sway During Sit-to-stand in Typical Children and Children with Cerebral Palsy. / 2019 / PubMed / Full text
Ectopic expression of VpSTS29, a stilbene synthase gene from Vitis pseudoreticulata, indicates STS presence in cytosolic oil bodies. / 07.2018 / PubMed / Full text
Short-Term Training and Detraining Effects of Supervised vs. Unsupervised Resistance Exercise in Aging Adults. / 10.2019 / PubMed / Full text
The coordination of joint movements during sit-to-stand motion in old adults: the uncontrolled manifold analysis. / 2017 / PubMed / Full text

FOXO1

l-Theanine attenuates liver aging by inhibiting advanced glycation end products in d-galactose-induced rats and reversing an imbalance of oxidative stress and inflammation. / 03.2020 / PubMed / Full text
Establishment of a Mouse Model of Premature Ovarian Failure Using Consecutive Superovulation. / 2018 / PubMed / Full text
Functional pathways regulated by microRNA networks in CD8 T-cell aging. / 02.2019 / PubMed / Full text
Introduction to FOXO Biology. / 2019 / PubMed / Full text
Antioxidant modifications induced by the new metformin derivative HL156A regulate metabolic reprogramming in SAMP1/kl (-/-) mice. / 16.09.2018 / PubMed / Full text
Master athletes have higher miR-7, SIRT3 and SOD2 expression in skeletal muscle than age-matched sedentary controls. / 10.2018 / PubMed / Full text
FOXO1 and ETV6 genes may represent novel regulators of splicing factor expression in cellular senescence. / 01.2019 / PubMed / Full text
Autophagy mediators (FOXO1, SESN3 and TSC2) in Lewy body disease and aging. / 25.09.2018 / PubMed / Full text
FOXO are required for intervertebral disk homeostasis during aging and their deficiency promotes disk degeneration. / 10.2018 / PubMed / Full text
Senescence Alters PPARγ (Peroxisome Proliferator-Activated Receptor Gamma)-Dependent Fatty Acid Handling in Human Adipose Tissue Microvascular Endothelial Cells and Favors Inflammation. / 05.2018 / PubMed / Full text
HGF and BFGF Secretion by Human Adipose-Derived Stem Cells Improves Ovarian Function During Natural Aging via Activation of the SIRT1/FOXO1 Signaling Pathway. / 2018 / PubMed / Full text
Role of Forkhead Box O (FOXO) transcription factor in aging and diseases. / 30.03.2018 / PubMed / Full text
FOXO in Neural Cells and Diseases of the Nervous System. / 2018 / PubMed / Full text
Clearance of senescent decidual cells by uterine natural killer cells in cycling human endometrium. / 11.12.2017 / PubMed / Full text
FOXO Transcriptional Factors and Long-Term Living. / 2017 / PubMed / Full text
Aquatide Activation of SIRT1 Reduces Cellular Senescence through a SIRT1-FOXO1-Autophagy Axis. / 01.09.2017 / PubMed / Full text

HP

A narrative review of highly processed food addiction across the lifespan. / 28.10.2020 / PubMed / Full text
Beta Human Papillomavirus 8E6 Attenuates LATS Phosphorylation after Failed Cytokinesis. / 01.06.2020 / PubMed / Full text
Cardiac baroreflex hysteresis is one of the determinants of the heart period variability asymmetry. / 01.10.2019 / PubMed / Full text
Aged rats with different performances at environmental enrichment onset display different modulation of habituation and aversive memory. / 05.2019 / PubMed / Full text
Extranuclear DNA accumulates in aged cells and contributes to senescence and inflammation. / 04.2019 / PubMed / Full text
Comparison between probabilistic and Wiener-Granger causality in assessing modifications of the cardiac baroreflex control with age. / 22.10.2018 / PubMed / Full text
CXCR3 CD8 T cells with naïve phenotype and high capacity for IFN-γ production are generated during homeostatic T-cell proliferation. / 10.2018 / PubMed / Full text
Mapping the Proxies of Memory and Learning Function in Senior Adults with High-performing, Normal Aging and Neurocognitive Disorders. / 2018 / PubMed / Full text
Role of Oral Nutritional Supplements Enriched with β-Hydroxy-β-Methylbutyrate in Maintaining Muscle Function and Improving Clinical Outcomes in Various Clinical Settings. / 2018 / PubMed / Full text
Effect of protein intake beyond habitual intakes following resistance training on cardiometabolic risk disease parameters in pre-conditioned older women. / 09.2018 / PubMed / Full text
Health care providers' perceptions of family caregivers' involvement in consultations within a geriatric hospital setting. / 07-08.2018 / PubMed / Full text
Influence of age and gender on the phase and strength of the relation between heart period and systolic blood pressure spontaneous fluctuations. / 01.03.2018 / PubMed / Full text
Species-specific role of gene-adjacent retroelements in human and mouse gastric carcinogenesis. / 15.04.2018 / PubMed / Full text
Associations of Helicobacter pylori infection and chronic atrophic gastritis with accelerated epigenetic ageing in older adults. / 10.10.2017 / PubMed / Full text
Aging Does Not Affect Axon Initial Segment Structure and Somatic Localization of Tau Protein in Hippocampal Neurons of Fischer 344 Rats. / 07-08.2017 / PubMed / Full text
Knee extensor power asymmetry is unrelated to functional mobility of older adults. / 11.2017 / PubMed / Full text

ACE2

How Does SARS-CoV-2 Affect the Central Nervous System? A Working Hypothesis. / 2020 / PubMed / Full text
Bioinformatic characterization of angiotensin-converting enzyme 2, the entry receptor for SARS-CoV-2. / 2020 / PubMed / Full text
A mouse-adapted model of SARS-CoV-2 to test COVID-19 countermeasures. / 10.2020 / PubMed / Full text
COVID-19 and Senotherapeutics: Any Role for the Naturally-occurring Dipeptide Carnosine? / 07.2020 / PubMed / Full text
The dual impact of ACE2 in COVID-19 and ironical actions in geriatrics and pediatrics with possible therapeutic solutions. / 15.09.2020 / PubMed / Full text
The possible pathophysiology mechanism of cytokine storm in elderly adults with COVID-19 infection: the contribution of "inflame-aging". / 09.2020 / PubMed / Full text
Decoding SARS-CoV-2 hijacking of host mitochondria in COVID-19 pathogenesis. / 01.08.2020 / PubMed / Full text
A Mouse Model of SARS-CoV-2 Infection and Pathogenesis. / 08.07.2020 / PubMed / Full text
COVID-19-associated cardiovascular morbidity in older adults: a position paper from the Italian Society of Cardiovascular Researches. / 08.2020 / PubMed / Full text
Gut microbiota and Covid-19- possible link and implications. / 08.2020 / PubMed / Full text
Inflamm-aging: Why older men are the most susceptible to SARS-CoV-2 complicated outcomes. / 06.2020 / PubMed / Full text
Restoration of the Renin-Angiotensin System Balance Is a Part of the Effect of Fasting on Cardiovascular Rejuvenation: Role of Age and Fasting Models. / 08.2020 / PubMed / Full text
Angiotensin 1-7 alleviates aging-associated muscle weakness and bone loss, but is not associated with accelerated aging in ACE2-knockout mice. / 30.09.2019 / PubMed / Full text
Age-dependent differences in pulmonary host responses in ARDS: a prospective observational cohort study. / 14.05.2019 / PubMed / Full text
The protective effect of resveratrol on vascular aging by modulation of the renin-angiotensin system. / 03.2018 / PubMed / Full text

APC

Differences between blacks and whites in well-being, beliefs, emotional states, behaviors and survival, 1978-2014. / 2020 / PubMed / Full text
Wnt-induced, TRP53-mediated Cell Cycle Arrest of Precursors Underlies Interstitial Cell of Cajal Depletion During Aging. / 07.08.2020 / PubMed / Full text
Burden of musculoskeletal disorders in Iran during 1990-2017: estimates from the Global Burden of Disease Study 2017. / 10.07.2020 / PubMed / Full text
Fall-related mortality trends in older Japanese adults aged ≥65 years: a nationwide observational study. / 11.12.2019 / PubMed / Full text
Stroke Mortality Rates and Trends in Romania, 1994-2017. / 12.2019 / PubMed / Full text
A new approach to quantifying the EEG during walking: Initial evidence of gait related potentials and their changes with aging and dual tasking. / 15.10.2019 / PubMed / Full text
Risk-period-cohort approach for averting identification problems in longitudinal models. / 2019 / PubMed / Full text
Wnt Signaling Mediates the Aging-Induced Differentiation Impairment of Intestinal Stem Cells. / 06.2019 / PubMed / Full text
Biased estimation of trends in cohort effects: the problems with age-period-cohort models in ecology. / 12.2018 / PubMed / Full text
[Gender Differences in Projected Life Expectancy in Japan (2023-2047) Determined by Bayesian Age-Period-Cohort Analysis]. / 2018 / PubMed / Full text
Activated Yes-Associated Protein Accelerates Cell Cycle, Inhibits Apoptosis, and Delays Senescence in Human Periodontal Ligament Stem Cells. / 2018 / PubMed / Full text
Activating the Anaphase Promoting Complex to Enhance Genomic Stability and Prolong Lifespan. / 27.06.2018 / PubMed / Full text
Effect of senescence marker protein 30 on the proliferation and apoptosis of human lens epithelial cells SRA01/04. / 2018 / PubMed / Full text
[Role and alterations of DNA methylation during the aging and cancer]. / 01.2018 / PubMed / Full text
MicroRNA-210-mediated proliferation, survival, and angiogenesis promote cardiac repair post myocardial infarction in rodents. / 12.2017 / PubMed / Full text

CD44

Hyaluronan goes to great length. / 17.07.2020 / PubMed / Full text
Naked mole-rat very-high-molecular-mass hyaluronan exhibits superior cytoprotective properties. / 12.05.2020 / PubMed / Full text
Maturity-dependent cartilage cell plasticity and sensitivity to external perturbation. / 06.2020 / PubMed / Full text
Aged Mice Exhibit Severe Exacerbations of Dry Eye Disease with an Amplified Memory Th17 Cell Response. / 07.2020 / PubMed / Full text
Chronic circadian misalignment accelerates immune senescence and abbreviates lifespan in mice. / 13.02.2020 / PubMed / Full text
Defective induction of the proteasome associated with T-cell receptor signaling underlies T-cell senescence. / 12.2019 / PubMed / Full text
CD44v8-10 and CD44s Are Age-dependently Expressed in Primary Cultured Papillary Thyroid Carcinoma Cells and Are Associated with Cell Proliferation. / 25.04.2019 / PubMed / Full text
Immunophenotypic characterization, multi-lineage differentiation and aging of zebrafish heart and liver tissue-derived mesenchymal stem cells as a novel approach in stem cell-based therapy. / 04.2019 / PubMed / Full text
CD8 , but not CD4 effector/memory T cells, express the [[CD44]] CD45RB phenotype with aging, which displays reduced expression levels of P2X receptor and ATP-induced cellular responses. / 03.2019 / PubMed / Full text
Regenerative potential of human nucleus pulposus resident stem/progenitor cells declines with ageing and intervertebral disc degeneration. / 10.2018 / PubMed / Full text
Multi-color flow cytometry for evaluating age-related changes in memory lymphocyte subsets in dogs. / 10.2018 / PubMed / Full text
Therapeutic efficacy of olfactory stem cells in rotenone induced Parkinsonism in adult male albino rats. / 07.2018 / PubMed / Full text
Precise Intradermal Injection of Nanofat-Derived Stromal Cells Combined with Platelet-Rich Fibrin Improves the Efficacy of Facial Skin Rejuvenation. / 2018 / PubMed / Full text
Some chemotherapeutics-treated colon cancer cells display a specific phenotype being a combination of stem-like and senescent cell features. / 02.01.2018 / PubMed / Full text
A Trickster in Disguise: Hyaluronan's Ambivalent Roles in the Matrix. / 2017 / PubMed / Full text

CORT

Sex differences in body composition, metabolism-related hormones, and energy homeostasis during aging in Wistar rats. / 10.2020 / PubMed / Full text
Effects of age and social isolation on murine hippocampal biochemistry and behavior. / 10.2020 / PubMed / Full text
Interleukin 6 reduces allopregnanolone synthesis in the brain and contributes to age-related cognitive decline in mice. / 10.2020 / PubMed / Full text
Sex- and age-dependent differences in the hormone and drinking responses to water deprivation. / 01.03.2020 / PubMed / Full text
Ontogeny of the adrenocortical response in an extremely altricial bird. / 12.2019 / PubMed / Full text
Exposure to jet lag aggravates depression-like behaviors and age-related phenotypes in rats subject to chronic corticosterone. / 05.08.2019 / PubMed / Full text
Hyperadrenocorticism of calorie restriction contributes to its anti-inflammatory action in mice. / 06.2019 / PubMed / Full text
Effect of chronic corticosterone-induced depression on circadian rhythms and age-related phenotypes in mice. / 01.12.2018 / PubMed / Full text
Early Life Stress Strengthens Trait Covariance: A Plastic Response That Results in Reduced Flexibility. / 11.2018 / PubMed / Full text
Both Basal and Acute Restraint Stress-Induced c-Fos Expression Is Influenced by Age in the Extended Amygdala and Brainstem Stress Centers in Male Rats. / 2018 / PubMed / Full text
Stress-induced corticosterone secretion covaries with working memory in aging. / 11.2018 / PubMed / Full text
Sex-specific differences in corticosterone secretion, behavioral phenotypes and expression of TrkB.T1 and TrkB.FL receptor isoforms: Impact of systemic TrkB inhibition and combinatory stress exposure in adolescence. / 30.08.2018 / PubMed / Full text
Lifelong Aerobic Exercise Reduces the Stress Response in Rats. / 15.04.2018 / PubMed / Full text
sst -receptor gene deletion exacerbates chronic stress-induced deficits: Consequences for emotional and cognitive ageing. / 30.08.2018 / PubMed / Full text
Chronic corticosterone-induced depression mediates premature aging in rats. / 15.03.2018 / PubMed / Full text

DDT

Prognostic Value of a Test of Central Auditory Function in Conversion from Mild Cognitive Impairment to Dementia. / 2020 / PubMed / Full text
Uptake kinetics of four hydrophobic organic pollutants in the earthworm Eisenia andrei in aged laboratory-contaminated natural soils. / 01.04.2020 / PubMed / Full text
Adult exposure to insecticides causes persistent behavioral and neurochemical alterations in zebrafish. / 03-04.2020 / PubMed / Full text
Second generation effects of larval metal pollutant exposure on reproduction, longevity and insecticide tolerance in the major malaria vector Anopheles arabiensis (Diptera: Culicidae). / 07.01.2020 / PubMed / Full text
Protective effect of Pedro-Ximénez must against p,p'-DDE-induced liver damages in aged Mus spretus mice. / 02.2020 / PubMed / Full text
Low-dose endosulfan inhibits proliferation and induces senescence and pro-inflammatory cytokine production in human lymphocytes, preferentially impacting cytotoxic cells. / 12.2019 / PubMed / Full text
DNA damage tolerance in stem cells, ageing, mutagenesis, disease and cancer therapy. / 22.08.2019 / PubMed / Full text
The contribution of gut bacteria to insecticide resistance and the life histories of the major malaria vector Anopheles arabiensis (Diptera: Culicidae). / 24.06.2019 / PubMed / Full text
Exposure to the insecticide-treated bednet PermaNet 2.0 reduces the longevity of the wild African malaria vector Anopheles funestus but GSTe2-resistant mosquitoes live longer. / 2019 / PubMed / Full text
The occurrence and dynamics of polychlorinated hydrocarbons in roe deer ([i]Capreolus capreolus[/i]) in South-western Slovakia. / 2019 / PubMed / Full text
Insecticide resistance status of three vectors of Japanese encephalitis in east central India. / 06.2019 / PubMed / Full text
Effect of aging on bioaccessibility of DDTs and PCBs in marine sediment. / 02.2019 / PubMed / Full text
The effect of commercial herbicide exposure on the life history and insecticide resistance phenotypes of the major malaria vector Anopheles arabiensis (Diptera: culicidae). / 12.2018 / PubMed / Full text
Is Chronic Exposure to Low-Dose Organochlorine Pesticides a New Risk Factor of T-cell Immunosenescence? / 10.2018 / PubMed / Full text
The influence of age on insecticide susceptibility of Anopheles arabiensis during dry and rainy seasons in rice irrigation schemes of Northern Tanzania. / 11.09.2017 / PubMed / Full text

GDF15

Disease-specific plasma levels of mitokines FGF21, GDF15, and Humanin in type II diabetes and Alzheimer's disease in comparison with healthy aging. / 31.10.2020 / PubMed / Full text
Growth differentiation factor 15 protects against the aging-mediated systemic inflammatory response in humans and mice. / 08.2020 / PubMed / Full text
Analysis of Epigenetic Age Predictors in Pain-Related Conditions. / 2020 / PubMed / Full text
GDF15 Plasma Level Is Inversely Associated With Level of Physical Activity and Correlates With Markers of Inflammation and Muscle Weakness. / 2020 / PubMed / Full text
GDF15 is an epithelial-derived biomarker of idiopathic pulmonary fibrosis. / 01.10.2019 / PubMed / Full text
Senescence-associated tissue microenvironment promotes colon cancer formation through the secretory factor GDF15. / 12.2019 / PubMed / Full text
mTORC1 underlies age-related muscle fiber damage and loss by inducing oxidative stress and catabolism. / 06.2019 / PubMed / Full text
Expression of lipogenic markers is decreased in subcutaneous adipose tissue and adipocytes of older women and is negatively linked to GDF15 expression. / 08.2019 / PubMed / Full text
Growth differentiation factor 15 (GDF15): A survival protein with therapeutic potential in metabolic diseases. / 06.2019 / PubMed / Full text
[The role of «Youth and aging proteins» in essential hypertension pathogenesis.] / 2018 / PubMed
A framework for selection of blood-based biomarkers for geroscience-guided clinical trials: report from the TAME Biomarkers Workgroup. / 12.2018 / PubMed / Full text
Towards frailty biomarkers: Candidates from genes and pathways regulated in aging and age-related diseases. / 11.2018 / PubMed / Full text
Plasma proteomic signature of age in healthy humans. / 10.2018 / PubMed / Full text
Human Aging and Longevity Are Characterized by High Levels of Mitokines. / 23.04.2019 / PubMed / Full text
Induction of Growth Differentiation Factor 15 in Skeletal Muscle of Old Taurine Transporter Knockout Mouse. / 2018 / PubMed / Full text

LRRK2

Accelerated telomere shortening independent of LRRK2 variants in Chinese patients with Parkinson's disease. / 29.10.2020 / PubMed / Full text
The effect of LRRK2 loss-of-function variants in humans. / 06.2020 / PubMed / Full text
Parkinson's disease-related Leucine-rich repeat kinase 2 modulates nuclear morphology and genomic stability in striatal projection neurons during aging. / 19.02.2020 / PubMed / Full text
Autophagy and LRRK2 in the Aging Brain. / 2019 / PubMed / Full text
SerThr-PhosphoProteome of Brain from Aged PINK1-KO+A53T-SNCA Mice Reveals pT1928-MAP1B and pS3781-ANK2 Deficits, as Hub between Autophagy and Synapse Changes. / 04.07.2019 / PubMed / Full text
Age-dependent accumulation of oligomeric SNCA/α-synuclein from impaired degradation in mutant LRRK2 knockin mouse model of Parkinson disease: role for therapeutic activation of chaperone-mediated autophagy (CMA). / 02.2020 / PubMed / Full text
A Neuron-Glial Trans-Signaling Cascade Mediates LRRK2-Induced Neurodegeneration. / 12.02.2019 / PubMed / Full text
Upregulation of the p53-p21 pathway by G2019S LRRK2 contributes to the cellular senescence and accumulation of α-synuclein. / 02.2019 / PubMed / Full text
G2019S LRRK2 mutation facilitates α-synuclein neuropathology in aged mice. / 12.2018 / PubMed / Full text
The Enzymatic Core of the Parkinson's Disease-Associated Protein LRRK2 Impairs Mitochondrial Biogenesis in Aging Yeast. / 2018 / PubMed / Full text
Age-related pathology after adenoviral overexpression of the leucine-rich repeat kinase 2 in the mouse striatum. / 06.2018 / PubMed / Full text
LRRK2 G2019S Induces Anxiety/Depression-like Behavior before the Onset of Motor Dysfunction with 5-HT Receptor Upregulation in Mice. / 14.02.2018 / PubMed / Full text
Age-Dependent Dopaminergic Neurodegeneration and Impairment of the Autophagy-Lysosomal Pathway in LRRK-Deficient Mice. / 15.11.2017 / PubMed / Full text
Initial elevations in glutamate and dopamine neurotransmission decline with age, as does exploratory behavior, in LRRK2 G2019S knock-in mice. / 20.09.2017 / PubMed / Full text
Suppression of neuroinflammation by matrix metalloproteinase-8 inhibitor in aged normal and LRRK2 G2019S Parkinson's disease model mice challenged with lipopolysaccharide. / 18.11.2017 / PubMed / Full text

MET

Self-rated health in relation to fruit and vegetable consumption and physical activity among older cancer survivors. / 26.09.2020 / PubMed / Full text
Leisure-time physical activity volume, intensity, and duration from mid- to late-life in U.S. subpopulations by race and sex. The Atherosclerosis Risk In Communities (ARIC) Study. / 13.03.2020 / PubMed / Full text
Repressive H3K9me2 protects lifespan against the transgenerational burden of COMPASS activity in [i]C. elegans[/i]. / 09.12.2019 / PubMed / Full text
Influence of Anthropometrics on Step-Rate Thresholds for Moderate and Vigorous Physical Activity in Older Adults: Scientific Modeling Study. / 13.12.2018 / PubMed / Full text
Physical activity, multimorbidity, and life expectancy: a UK Biobank longitudinal study. / 12.06.2019 / PubMed / Full text
Metformin prevents murine ovarian aging. / 10.06.2019 / PubMed / Full text
Afterword: Oral Methioninase-Answer to Cancer and Fountain of Youth? / 2019 / PubMed / Full text
Leveraging Household Structure for Increasing Adult Physical Activity in a Low-Income, African American Community. / 07.2020 / PubMed / Full text
Appropriate Amount of Regular Exercise Is Associated with a Reduced Mortality Risk. / 12.2018 / PubMed / Full text
The Relationship between Cardiorespiratory Fitness and Montreal Cognitive Assessment Scores in Older Adults. / 2018 / PubMed / Full text
Metabolic adaptation of short-living growth hormone transgenic mice to methionine restriction and supplementation. / 04.2018 / PubMed / Full text
Does the use of outdoor fitness equipment by older adults qualify as moderate to vigorous physical activity? / 2018 / PubMed / Full text
Hypoxia-inducible transcription factors, HIF1A and HIF2A, increase in aging mucosal tissues. / 07.2018 / PubMed / Full text
The metabolic equivalents of one-mile walking by older adults; implications for health promotion. / 2017 / PubMed / Full text
The effect of age on fitness among female firefighters. / 01.10.2017 / PubMed / Full text

ABR

[Hidden hearing loss and early identification]. / 07.2020 / PubMed / Full text
Aging But Not Age-Related Hearing Loss Dominates the Decrease of Parvalbumin Immunoreactivity in the Primary Auditory Cortex of Mice. / 05-06.2020 / PubMed / Full text
Hearing loss through apoptosis of the spiral ganglion neurons in apolipoprotein E knockout mice fed with a western diet. / 12.03.2020 / PubMed / Full text
Effects of enriched endogenous omega-3 fatty acids on age-related hearing loss in mice. / 26.11.2019 / PubMed / Full text
Hearing impairment and associated morphological changes in pituitary adenylate cyclase activating polypeptide (PACAP)-deficient mice. / 10.10.2019 / PubMed / Full text
Global nurse/midwife workforce and reproductive health through social ecology lens. / 09.2019 / PubMed / Full text
Urocortin 3 signalling in the auditory brainstem aids recovery of hearing after reversible noise-induced threshold shift. / 08.2019 / PubMed / Full text
Age‑associated variation in the expression and function of TMEM16A calcium‑activated chloride channels in the cochlear stria vascularis of guinea pigs. / 08.2019 / PubMed / Full text
Hormone replacement therapy attenuates hearing loss: Mechanisms involving estrogen and the IGF-1 pathway. / 06.2019 / PubMed / Full text
Evidence for age-related cochlear synaptopathy in humans unconnected to speech-in-noise intelligibility deficits. / 15.03.2019 / PubMed / Full text
Masking Differentially Affects Envelope-following Responses in Young and Aged Animals. / 21.08.2018 / PubMed / Full text
Effects of Age on Speech-in-Noise Identification: Subjective Ratings of Hearing Difficulties and Encoding of Fundamental Frequency in Older Adults. / 06.2018 / PubMed / Full text
Age-Related Differences in Hearing Function and Cochlear Morphology between Male and Female Fischer 344 Rats. / 2017 / PubMed / Full text
The FBN rat model of aging: investigation of ABR waveforms and ribbon synapse changes. / 02.2018 / PubMed / Full text

CD36

Liver osteopontin is required to prevent the progression of age-related nonalcoholic fatty liver disease. / 08.2020 / PubMed / Full text
Reduction of senescence-associated beta-galactosidase activity by vitamin E in human fibroblasts depends on subjects' age and cell passage number. / 07.2020 / PubMed / Full text
Niacin-mediated rejuvenation of macrophage/microglia enhances remyelination of the aging central nervous system. / 05.2020 / PubMed / Full text
Human bone marrow adipocytes display distinct immune regulatory properties. / 08.2019 / PubMed / Full text
Expression of digestive enzyme and intestinal transporter genes during chronic heat stress in the thermally manipulated broiler chicken. / 01.09.2019 / PubMed / Full text
Pathophysiological significance of cylindromatosis in the vascular endothelium and macrophages for the initiation of age-related atherogenesis. / 22.01.2019 / PubMed / Full text
The adhesion and migration of microglia to β-amyloid (Aβ) is decreased with aging and inhibited by Nogo/NgR pathway. / 20.07.2018 / PubMed / Full text
Cell-surface phenotyping identifies CD36 and CD97 as novel markers of fibroblast quiescence in lung fibrosis. / 01.11.2018 / PubMed / Full text
An evolutionary transcriptomics approach links CD36 to membrane remodeling in replicative senescence. / 06.08.2018 / PubMed / Full text
Comparative analysis of endothelial cell and sub-endothelial cell elastic moduli in young and aged mice: Role of CD36. / 25.07.2018 / PubMed / Full text
CD36 initiates the secretory phenotype during the establishment of cellular senescence. / 06.2018 / PubMed / Full text
Senescence Alters PPARγ (Peroxisome Proliferator-Activated Receptor Gamma)-Dependent Fatty Acid Handling in Human Adipose Tissue Microvascular Endothelial Cells and Favors Inflammation. / 05.2018 / PubMed / Full text
Developmental differences between neonatal and adult human erythropoiesis. / 08.2018 / PubMed / Full text
Effects of high-fat diet and age on the blood lipidome and circulating endocannabinoids of female C57BL/6 mice. / 01.2018 / PubMed / Full text

CDK4

Emerging Roles for the [i]INK4a/ARF[/i] ([i]CDKN2A[/i]) Locus in Adipose Tissue: Implications for Obesity and Type 2 Diabetes. / 22.09.2020 / PubMed / Full text
Guilu Erxian Glue () Inhibits Chemotherapy-Induced Bone Marrow Hematopoietic Stem Cell Senescence in Mice May via p16 -Rb Signaling Pathway. / 11.2020 / PubMed / Full text
Induction of Senescence in Cancer Cells by a Novel Combination of Cucurbitacin B and Withanone: Molecular Mechanism and Therapeutic Potential. / 22.05.2020 / PubMed / Full text
Ribosomal protein RPL22/eL22 regulates the cell cycle by acting as an inhibitor of the CDK4-cyclin D complex. / 03-04.2019 / PubMed / Full text
p16 deletion in cells of the intervertebral disc affects their matrix homeostasis and senescence associated secretory phenotype without altering onset of senescence. / 09.2019 / PubMed / Full text
Efficient immortalization of cells derived from critically endangered Tsushima leopard cat (Prionailurus bengalensis euptilurus) with expression of mutant CDK4, Cyclin D1, and telomerase reverse transcriptase. / 12.2018 / PubMed / Full text
Effects of Fibronectin 1 on Cell Proliferation, Senescence and Apoptosis of Human Glioma Cells Through the PI3K/AKT Signaling Pathway. / 2018 / PubMed / Full text
Cyclin D1 depletion interferes with oxidative balance and promotes cancer cell senescence. / 25.06.2018 / PubMed / Full text
Fucoidan Rescues p-Cresol-Induced Cellular Senescence in Mesenchymal Stem Cells via FAK-Akt-TWIST Axis. / 06.04.2018 / PubMed / Full text
Carvacrol nanoemulsion evokes cell cycle arrest, apoptosis induction and autophagy inhibition in doxorubicin resistant-A549 cell line. / 2018 / PubMed / Full text
Mechanistic understanding of the role of ATRX in senescence provides new insight for combinatorial therapies with CDK4 inhibitors. / 2018 / PubMed / Full text
Glutaredoxin-1 Silencing Induces Cell Senescence via p53/p21/p16 Signaling Axis. / 02.03.2018 / PubMed / Full text
Inhibition of CIP2A attenuates tumor progression by inducing cell cycle arrest and promoting cellular senescence in hepatocellular carcinoma. / 08.01.2018 / PubMed / Full text
Preclinical characterization of abemaciclib in hormone receptor positive breast cancer. / 19.09.2017 / PubMed / Full text

DMD

Aldehyde dehydrogenases contribute to skeletal muscle homeostasis in healthy, aging, and Duchenne muscular dystrophy patients. / 08.2020 / PubMed / Full text
Life expectancy at birth in Duchenne muscular dystrophy: a systematic review and meta-analysis. / 07.2020 / PubMed / Full text
Renal dysfunction can occur in advanced-stage Duchenne muscular dystrophy. / 02.2020 / PubMed / Full text
The long dystrophin gene product Dp427 modulates retinal function and vascular morphology in response to age and retinal ischemia. / 10.2019 / PubMed / Full text
Hemojuvelin is a novel suppressor for Duchenne muscular dystrophy and age-related muscle wasting. / 06.2019 / PubMed / Full text
Age-dependent changes in metabolite profile and lipid saturation in dystrophic mice. / 05.2019 / PubMed / Full text
Muscle function and age are associated with loss of bone mineral density in Duchenne muscular dystrophy. / 04.2019 / PubMed / Full text
Use of bone age for evaluating bone density in patients with Duchenne muscular dystrophy: A preliminary report. / 04.2019 / PubMed / Full text
Age- and Expertise-Related Differences of Sensorimotor Network Dynamics during Force Control. / 15.09.2018 / PubMed / Full text
Mineralocorticoid Receptor Antagonists in Muscular Dystrophy Mice During Aging and Exercise. / 2018 / PubMed / Full text
Calcium current properties in dystrophin-deficient ventricular cardiomyocytes from aged mdx mice. / 01.2018 / PubMed / Full text
Immunoglobulin therapy ameliorates the phenotype and increases lifespan in the severely affected dystrophin-utrophin double knockout mice. / 12.2017 / PubMed / Full text
The experience of parents of adult sons with Duchenne muscular dystrophy regarding their prolonged roles as primary caregivers: a serial qualitative study. / 04.2019 / PubMed / Full text
Spatial and age-related changes in the microstructure of dystrophic and healthy diaphragms. / 2017 / PubMed / Full text

FGF23

Phosphate as a Pathogen of Arteriosclerosis and Aging. / 08.10.2020 / PubMed / Full text
Plasma Soluble αKlotho, Serum Fibroblast Growth Factor 23, and Mobility Disability in Community-Dwelling Older Adults. / 01.05.2020 / PubMed / Full text
Protective effect of Polygonatum sibiricum Polysaccharide on D-galactose-induced aging rats model. / 10.02.2020 / PubMed / Full text
FGF23 expression is stimulated in transgenic α-Klotho longevity mouse model. / 05.12.2019 / PubMed / Full text
Fibroblast growth factor 23 and symmetric dimethylarginine concentrations in geriatric cats. / 11.2019 / PubMed / Full text
Muscle-bone crosstalk and potential therapies for sarco-osteoporosis. / 09.2019 / PubMed / Full text
Extraskeletal Calcifications in Hutchinson-Gilford Progeria Syndrome. / 08.2019 / PubMed / Full text
Genome-wide associations and detection of potential candidate genes for direct genetic and maternal genetic effects influencing dairy cattle body weight at different ages. / 06.02.2019 / PubMed / Full text
Age-Related Changes and Effects of Bisphosphonates on Bone Turnover and Disease Progression in Fibrous Dysplasia of Bone. / 04.2019 / PubMed / Full text
Kotho and aging. / 09.2016 / PubMed
The Klotho proteins in health and disease. / 01.2019 / PubMed / Full text
Wnt signaling in bone, kidney, intestine, and adipose tissue and interorgan interaction in aging. / 04.2019 / PubMed / Full text
Towards frailty biomarkers: Candidates from genes and pathways regulated in aging and age-related diseases. / 11.2018 / PubMed / Full text
New Insights into the Mechanism of Action of Soluble Klotho. / 2017 / PubMed / Full text

MAPT

Association of relative brain age with tobacco smoking, alcohol consumption, and genetic variants. / 30.01.2020 / PubMed / Full text
A blood-based nutritional risk index explains cognitive enhancement and decline in the multidomain Alzheimer prevention trial. / 2019 / PubMed / Full text
Longitudinal associations of physical activity levels with morphological and functional changes related with aging: The MAPT study. / 12.2019 / PubMed / Full text
Ageing and amyloidosis underlie the molecular and pathological alterations of tau in a mouse model of familial Alzheimer's disease. / 31.10.2019 / PubMed / Full text
Revisiting the intersection of amyloid, pathologically modified tau and iron in Alzheimer's disease from a ferroptosis perspective. / 01.2020 / PubMed / Full text
Factors associated with changes of the frailty status after age 70: Findings in the MAPT study. / 06.2019 / PubMed / Full text
Mitophagy and NAD inhibit Alzheimer disease. / 06.2019 / PubMed / Full text
Cognitive changes of older adults with an equivocal amyloid load. / 04.2019 / PubMed / Full text
Tauopathy: A common mechanism for neurodegeneration and brain aging. / 03.2019 / PubMed / Full text
Cinnamaldehyde Improves Lifespan and Healthspan in [i]Drosophila melanogaster[/i] Models for Alzheimer's Disease. / 2018 / PubMed / Full text
Sex and age interact to determine clinicopathologic differences in Alzheimer's disease. / 12.2018 / PubMed / Full text
Effects of a 3-Year Multi-Domain Intervention with or without Omega-3 Supplementation on Cognitive Functions in Older Subjects with Increased CAIDE Dementia Scores. / 2018 / PubMed / Full text
Whole-Exome Sequencing of an Exceptional Longevity Cohort. / 16.08.2019 / PubMed / Full text
Interaction between a MAPT variant causing frontotemporal dementia and mutant APP affects axonal transport. / 08.2018 / PubMed / Full text

SOX2

Multiple nanosecond pulsed electric fields stimulation with conductive poly(l-lactic acid)/carbon nanotubes films maintains the multipotency of mesenchymal stem cells during prolonged in vitro culture. / 08.2020 / PubMed / Full text
Subpopulations of miniature pig mesenchymal stromal cells with different differentiation potentials differ in the expression of octamer-binding transcription factor 4 and sex determining region Y-box 2. / 03.2020 / PubMed / Full text
Increased Type I and Decreased Type II Hair Cells after Deletion of Sox2 in the Developing Mouse Utricle. / 01.12.2019 / PubMed / Full text
'Stemness' and 'senescence' related escape pathways are dose dependent in lung cancer cells surviving post irradiation. / 01.09.2019 / PubMed / Full text
Cellular senescence in progenitor cells contributes to diminished remyelination potential in progressive multiple sclerosis. / 30.04.2019 / PubMed / Full text
The senescent status of endothelial cells affects proliferation, inflammatory profile and SOX2 expression in bone marrow-derived mesenchymal stem cells. / 06.2019 / PubMed / Full text
Isolation, Characterization, and Differentiation of Cardiac Stem Cells from the Adult Mouse Heart. / 07.01.2019 / PubMed / Full text
A stably self-renewing adult blood-derived induced neural stem cell exhibiting patternability and epigenetic rejuvenation. / 02.10.2018 / PubMed / Full text
MicroRNA-338-5p plays a tumor suppressor role in glioma through inhibition of the MAPK-signaling pathway by binding to FOXD1. / 12.2018 / PubMed / Full text
Centenarians Overexpress Pluripotency-Related Genes. / 16.08.2019 / PubMed / Full text
MYC Releases Early Reprogrammed Human Cells from Proliferation Pause via Retinoblastoma Protein Inhibition. / 10.04.2018 / PubMed / Full text
SOX2 expression diminishes with ageing in several tissues in mice and humans. / 01.2019 / PubMed / Full text
Coupling shRNA screens with single-cell RNA-seq identifies a dual role for mTOR in reprogramming-induced senescence. / 15.10.2017 / PubMed / Full text
ZSCAN10 expression corrects the genomic instability of iPSCs from aged donors. / 09.2017 / PubMed / Full text

TFEB

A Novel Lipofuscin-detecting Marker of Senescence Relates With Hypoxia, Dysregulated Autophagy and With Poor Prognosis in Non-small-cell-lung Cancer. / 11-12.2020 / PubMed / Full text
ESC-sEVs Rejuvenate Senescent Hippocampal NSCs by Activating Lysosomes to Improve Cognitive Dysfunction in Vascular Dementia. / 05.2020 / PubMed / Full text
Nitrative Stress-Related Autophagic Insufficiency Participates in Hyperhomocysteinemia-Induced Renal Aging. / 2020 / PubMed / Full text
Polyamines reverse immune senescence via the translational control of autophagy. / 01.2020 / PubMed / Full text
Polyamines Control eIF5A Hypusination, TFEB Translation, and Autophagy to Reverse B Cell Senescence. / 03.10.2019 / PubMed / Full text
Insulin-like peptides and the mTOR-TFEB pathway protect [i]Caenorhabditis elegans[/i] hermaphrodites from mating-induced death. / 08.07.2019 / PubMed / Full text
Double knockout of Akt2 and AMPK predisposes cardiac aging without affecting lifespan: Role of autophagy and mitophagy. / 01.07.2019 / PubMed / Full text
TFEB protects nucleus pulposus cells against apoptosis and senescence via restoring autophagic flux. / 02.2019 / PubMed / Full text
Autophagy and mitophagy flux in young and aged skeletal muscle following chronic contractile activity. / 08.2018 / PubMed / Full text
Nuclear Export Inhibition Enhances HLH-30/TFEB Activity, Autophagy, and Lifespan. / 15.05.2018 / PubMed / Full text
Trans-Fats Inhibit Autophagy Induced by Saturated Fatty Acids. / 04.2018 / PubMed / Full text
Small-molecule TFEB pathway agonists that ameliorate metabolic syndrome in mice and extend C. elegans lifespan. / 22.12.2017 / PubMed / Full text
Peroxisomes contribute to oxidative stress in neurons during doxorubicin-based chemotherapy. / 01.2018 / PubMed / Full text
TOR-mediated regulation of metabolism in aging. / 12.2017 / PubMed / Full text

AFM

Photocatalytic aging process of Nano-TiO coated polypropylene microplastics: Combining atomic force microscopy and infrared spectroscopy (AFM-IR) for nanoscale chemical characterization. / 15.02.2021 / PubMed / Full text
Nanoscale infrared, thermal and mechanical properties of aged microplastics revealed by an atomic force microscopy coupled with infrared spectroscopy (AFM-IR) technique. / 20.11.2020 / PubMed / Full text
Detecting zeta potential of polydimethylsiloxane (PDMS) in electrolyte solutions with atomic force microscope. / 15.10.2020 / PubMed / Full text
Recent Applications of Advanced Atomic Force Microscopy in Polymer Science: A Review. / 17.05.2020 / PubMed / Full text
Active fractions of mannoproteins derived from yeast cell wall stimulate innate and acquired immunity of adult and elderly dogs. / 03.2020 / PubMed / Full text
The Effect of Waste Engine Oil and Waste Polyethylene on UV Aging Resistance of Asphalt. / 06.03.2020 / PubMed / Full text
Mechanical properties measured by atomic force microscopy define health biomarkers in ageing C. elegans. / 25.02.2020 / PubMed / Full text
Nanomechanical insights: Amyloid beta oligomer-induced senescent brain endothelial cells. / 01.12.2019 / PubMed / Full text
Application of atomic force microscopy in the analysis of time since deposition (TSD) of red blood cells in bloodstains: A forensic analysis. / 08.2019 / PubMed / Full text
Iceland spar calcite: Humidity and time effects on surface properties and their reversibility. / 01.04.2019 / PubMed / Full text
Zebrafish as a model to study bone maturation: Nanoscale structural and mechanical characterization of age-related changes in the zebrafish vertebral column. / 08.2018 / PubMed / Full text
Multiscale Poroviscoelastic Compressive Properties of Mouse Supraspinatus Tendons Are Altered in Young and Aged Mice. / 01.05.2018 / PubMed / Full text
Proteomic Alterations Associated with Biomechanical Dysfunction are Early Processes in the Emilin1 Deficient Mouse Model of Aortic Valve Disease. / 11.2017 / PubMed / Full text

ASL

Increased blood-brain barrier permeability to water in the aging brain detected using noninvasive multi-TE ASL MRI. / 01.2021 / PubMed / Full text
Quantitative Cerebrovascular Reactivity in Normal Aging: Comparison Between Phase-Contrast and Arterial Spin Labeling MRI. / 2020 / PubMed / Full text
Correcting Task fMRI Signals for Variability in Baseline CBF Improves BOLD-Behavior Relationships: A Feasibility Study in an Aging Model. / 2020 / PubMed / Full text
Cerebral Blood Flow in Community-Based Older Twins Is Moderately Heritable: An Arterial Spin Labeling Perfusion Imaging Study. / 2019 / PubMed / Full text
A longitudinal characterization of perfusion in the aging brain and associations with cognition and neural structure. / 15.08.2019 / PubMed / Full text
Cortical cerebral blood flow in ageing: effects of haematocrit, sex, ethnicity and diabetes. / 10.2019 / PubMed / Full text
Exercise-stimulated arterial transit time in calf muscles measured by dynamic contrast-enhanced magnetic resonance imaging. / 01.2019 / PubMed / Full text
Impact of Coffee, Wine, and Chocolate Consumption on Cognitive Outcome and MRI Parameters in Old Age. / 01.10.2018 / PubMed / Full text
Potential Role of OERP as Early Marker of Mild Cognitive Impairment. / 2018 / PubMed / Full text
Reduced Regional Cerebral Blood Flow Relates to Poorer Cognition in Older Adults With Type 2 Diabetes. / 2018 / PubMed / Full text
The Age-Related Perfusion Pattern Measured With Arterial Spin Labeling MRI in Healthy Subjects. / 2018 / PubMed / Full text
Resilience and amygdala function in older healthy and depressed adults. / 09.2018 / PubMed / Full text
Does Aerobic Exercise Influence Intrinsic Brain Activity? An Aerobic Exercise Intervention among Healthy Old Adults. / 2017 / PubMed / Full text

CXCL1

Contusion spinal cord injury upregulates p53 protein expression in rat soleus muscle at multiple timepoints but not key senescence cytokines. / 02.2020 / PubMed / Full text
Systemic Inflammation and the Increased Risk of Inflamm-Aging and Age-Associated Diseases in People Living With HIV on Long Term Suppressive Antiretroviral Therapy. / 2019 / PubMed / Full text
Inflammatory and Senescent Phenotype of Pancreatic Stellate Cells Induced by Sqstm1 Downregulation Facilitates Pancreatic Cancer Progression. / 2019 / PubMed / Full text
Neuroprotective effects of targeting BET proteins for degradation with dBET1 in aged mice subjected to ischemic stroke. / 07.2019 / PubMed / Full text
Excessive neutrophil levels in the lung underlie the age-associated increase in influenza mortality. / 03.2019 / PubMed / Full text
Prophylactic Palmitoylethanolamide Prolongs Survival and Decreases Detrimental Inflammation in Aged Mice With Bacterial Meningitis. / 2018 / PubMed / Full text
The Role of Pulmonary and Systemic Immunosenescence in Acute Lung Injury. / 08.2018 / PubMed / Full text
Urine Cytokine and Chemokine Levels Predict Urinary Tract Infection Severity Independent of Uropathogen, Urine Bacterial Burden, Host Genetics, and Host Age. / 09.2018 / PubMed / Full text
Aerobic Exercise Protects from Pseudomonas aeruginosa-Induced Pneumonia in Elderly Mice. / 2018 / PubMed / Full text
Infiltrating macrophages contribute to age-related neuroinflammation in C57/BL6 mice. / 07.2018 / PubMed / Full text
Time-Dependent Changes in Local and Serum Levels of Inflammatory Cytokines as Markers for Incised Wound Aging of Skeletal Muscles. / 05.2018 / PubMed / Full text
Age-related decline of the acute local inflammation response: a mitigating role for the adenosine A receptor. / 18.10.2017 / PubMed / Full text
IFN-γ induces senescence-like characteristics in mouse bone marrow mesenchymal stem cells. / 03-04.2017 / PubMed / Full text

EGFR

Type I Collagen Aging Increases Expression and Activation of EGFR and Induces Resistance to Erlotinib in Lung Carcinoma in 3D Matrix Model. / 2020 / PubMed / Full text
Comparative effectiveness and cost-effectiveness of three first-line EGFR-tyrosine kinase inhibitors: Analysis of real-world data in a tertiary hospital in Taiwan. / 2020 / PubMed / Full text
An Optogenetic Method to Study Signal Transduction in Intestinal Stem Cell Homeostasis. / 01.05.2020 / PubMed / Full text
Treatment-Induced Tumor Dormancy through YAP-Mediated Transcriptional Reprogramming of the Apoptotic Pathway. / 13.01.2020 / PubMed / Full text
Association between EGFR mutation and ageing, history of pneumonia and gastroesophageal reflux disease among patients with advanced lung cancer. / 11.2019 / PubMed / Full text
Systems biology and network pharmacology of frailty reveal novel epigenetic targets and mechanisms. / 22.07.2019 / PubMed / Full text
The role of EGFR signaling in age-related osteoporosis in mouse cortical bone. / 10.2019 / PubMed / Full text
Regulation of RhoB Gene Expression during Tumorigenesis and Aging Process and Its Potential Applications in These Processes. / 13.06.2019 / PubMed / Full text
EGF/EGFR upregulates and cooperates with Netrin-4 to protect glioblastoma cells from DNA damage-induced senescence. / 04.12.2018 / PubMed / Full text
An Adult Drosophila Glioma Model for Studying Pathometabolic Pathways of Gliomagenesis. / 06.2019 / PubMed / Full text
Quantum Modeling: A Bridge between the Pumping and Signaling Functions of Na/K-ATPase. / 09.08.2018 / PubMed / Full text
Novel drug-resistance mechanisms of pemetrexed-treated non-small cell lung cancer. / 30.03.2018 / PubMed / Full text
Withanolide A extends the lifespan in human EGFR-driven cancerous Caenorhabditis elegans. / 04.2018 / PubMed / Full text

HMGB1

Senescent human melanocytes drive skin ageing via paracrine telomere dysfunction. / 02.12.2019 / PubMed / Full text
Targeting HMGB1 by ethyl pyruvate ameliorates systemic lupus erythematosus and reverses the senescent phenotype of bone marrow-mesenchymal stem cells. / 14.07.2019 / PubMed / Full text
HMGB1 and Caveolin-1 related to RPE cell senescence in age-related macular degeneration. / 07.07.2019 / PubMed / Full text
Dual faced HMGB1 plays multiple roles in cardiomyocyte senescence and cardiac inflammatory injury. / 06.2019 / PubMed / Full text
Neuroprotective Effect of Dioscin on the Aging Brain. / 30.03.2019 / PubMed / Full text
Modulation of soluble receptor for advanced glycation end-products (RAGE) isoforms and their ligands in healthy aging. / 23.03.2019 / PubMed / Full text
Cellular senescence in progenitor cells contributes to diminished remyelination potential in progressive multiple sclerosis. / 30.04.2019 / PubMed / Full text
Serum and nutrient deprivation increase autophagic flux in intervertebral disc annulus fibrosus cells: an in vitro experimental study. / 05.2019 / PubMed / Full text
Sirt3 mediates the protective effect of hydrogen in inhibiting ROS-induced retinal senescence. / 01.05.2019 / PubMed / Full text
Towards frailty biomarkers: Candidates from genes and pathways regulated in aging and age-related diseases. / 11.2018 / PubMed / Full text
Repeated abortion in adulthood induces cognition impairment in aged mice. / 30.07.2018 / PubMed / Full text
Loss of DNA polymerase β induces cellular senescence. / 08.2018 / PubMed / Full text
Nicotine-Induced Neuroprotection against Cognitive Dysfunction after Partial Hepatectomy Involves Activation of BDNF/TrkB Signaling Pathway and Inhibition of NF-κB Signaling Pathway in Aged Rats. / 06.03.2018 / PubMed / Full text

MDM2

SENEBLOC, a long non-coding RNA suppresses senescence via p53-dependent and independent mechanisms. / 06.04.2020 / PubMed / Full text
Disruption of Robo2-Baiap2 integrated signaling drives cystic disease. / 19.09.2019 / PubMed / Full text
Senescence-induced immunophenotype, gene expression and electrophysiology changes in human amniocytes. / 11.2019 / PubMed / Full text
Hsp90β interacts with MDM2 to suppress p53-dependent senescence during skeletal muscle regeneration. / 10.2019 / PubMed / Full text
TZAP plays an inhibitory role in the self-renewal of porcine mesenchymal stromal cells and is implicated the regulation of premature senescence via the p53 pathway. / 07.03.2019 / PubMed / Full text
Synaptotagmin-7, a binding protein of P53, inhibits the senescence and promotes the tumorigenicity of lung cancer cells. / 28.02.2019 / PubMed / Full text
The SCF ubiquitin ligase complex mediates degradation of the tumor suppressor FBXO31 and thereby prevents premature cellular senescence. / 19.10.2018 / PubMed / Full text
The Dysfunctional MDM2-p53 Axis in Adipocytes Contributes to Aging-Related Metabolic Complications by Induction of Lipodystrophy. / 11.2018 / PubMed / Full text
Effect of CCNB1 silencing on cell cycle, senescence, and apoptosis through the p53 signaling pathway in pancreatic cancer. / 01.2018 / PubMed / Full text
Boosting ATM activity alleviates aging and extends lifespan in a mouse model of progeria. / 02.05.2018 / PubMed / Full text
Acute HSF1 depletion induces cellular senescence through the MDM2-p53-p21 pathway in human diploid fibroblasts. / 08.05.2018 / PubMed / Full text
Relevance of the p53-MDM2 axis to aging. / 01.2018 / PubMed / Full text
Pomegranate peel extract attenuates D-galactose-induced oxidative stress and hearing loss by regulating PNUTS/PP1 activity in the mouse cochlea. / 11.2017 / PubMed / Full text

PTH

Vitamin D Receptor Polymorphisms in Sex-Frailty Paradox. / 05.09.2020 / PubMed / Full text
Parathyroid hormone ameliorates temporomandibular joint osteoarthritic-like changes related to age. / 04.2020 / PubMed / Full text
A Vitamin D, Calcium and Leucine-Enriched Whey Protein Nutritional Supplement Improves Measures of Bone Health in Sarcopenic Non-Malnourished Older Adults: The PROVIDE Study. / 10.2019 / PubMed / Full text
EVALUATION OF PLASMA 25-HYDROXYVITAMIN D, IONIZED CALCIUM, AND PARATHYROID HORMONE IN GREEN SEA TURTLES ([i]CHELONIA MYDAS[/i]) EXPOSED TO DIFFERENT INTENSITIES OF ULTRAVIOLET B RADIATION. / 13.06.2019 / PubMed / Full text
The relative influence of serum ionized calcium and 25-hydroxyvitamin D in regulating PTH secretion in healthy subjects. / 08.2019 / PubMed / Full text
Vitamin D in Relation to Incident Sarcopenia and Changes in Muscle Parameters Among Older Adults: The KORA-Age Study. / 08.2019 / PubMed / Full text
Extraskeletal Calcifications in Hutchinson-Gilford Progeria Syndrome. / 08.2019 / PubMed / Full text
Sequential Treatment with Eldecalcitol After PTH Improves Bone Mechanical Properties of Lumbar Spine and Femur in Aged Ovariectomized Rats. / 03.2019 / PubMed / Full text
Effect of Vitamin D Treatment on Glucose Homeostasis and Metabolism in Lebanese Older Adults: A Randomized Controlled Trial. / 2018 / PubMed / Full text
Testosterone level in aging male with different glucose tolerance state and its association with osteocalcin. / 03.2019 / PubMed / Full text
Early effects of parathyroid hormone on vascularized bone regeneration and implant osseointegration in aged rats. / 10.2018 / PubMed / Full text
Mito-mice∆ and mitochondrial DNA mutator mice as models of human osteoporosis caused not by aging but by hyperparathyroidism. / 01.11.2018 / PubMed / Full text
Intermittent PTH 1-34 administration improves the marrow microenvironment and endothelium-dependent vasodilation in bone arteries of aged rats. / 01.06.2018 / PubMed / Full text

TEC

Vestibular function and cortical and sub-cortical alterations in an aging population. / 08.2020 / PubMed / Full text
Metabolic Flexibility and Innate Immunity in Renal Ischemia Reperfusion Injury: The Fine Balance Between Adaptive Repair and Tissue Degeneration. / 2020 / PubMed / Full text
Postnatal Involution and Counter-Involution of the Thymus. / 2020 / PubMed / Full text
Gender Disparity Impacts on Thymus Aging and LHRH Receptor Antagonist-Induced Thymic Reconstitution Following Chemotherapeutic Damage. / 2020 / PubMed / Full text
Clonogenic Culture of Mouse Thymic Epithelial Cells. / 2019 / PubMed / Full text
TREM1/3 Deficiency Impairs Tissue Repair After Acute Kidney Injury and Mitochondrial Metabolic Flexibility in Tubular Epithelial Cells. / 2019 / PubMed / Full text
Interplay between Follistatin, Activin A, and BMP4 Signaling Regulates Postnatal Thymic Epithelial Progenitor Cell Differentiation during Aging. / 25.06.2019 / PubMed / Full text
Transgenic Exosomes for Thymus Regeneration. / 2019 / PubMed / Full text
Cell-type-specific role of lamin-B1 in thymus development and its inflammation-driven reduction in thymus aging. / 08.2019 / PubMed / Full text
Comparison of the Shear Bond Strength of Metal Orthodontic Brackets Bonded to Long-term Water-aged and Fresh Porcelain and Composite Surfaces. / 03.2019 / PubMed / Full text
Epithelial innate immunity mediates tubular cell senescence after kidney injury. / 24.01.2019 / PubMed / Full text
Thymic Epithelial Cell Support of Thymopoiesis Does Not Require [i]Klotho[/i]. / 01.12.2018 / PubMed / Full text
MicroRNAs Regulate Thymic Epithelium in Age-Related Thymic Involution via Down- or Upregulation of Transcription Factors. / 2017 / PubMed / Full text

ATF4

Endoplasmic Reticulum Stress Mediates Vascular Smooth Muscle Cell Calcification via Increased Release of Grp78-Loaded Extracellular Vesicles. / 10.12.2020 / PubMed / Full text
Extracellular acidosis triggers a senescence-like phenotype in human melanoma cells. / 01.2020 / PubMed / Full text
Chronic and age-dependent effects of the spongiform neurodegeneration-associated MGRN1 E3 ubiquitin ligase on mitochondrial homeostasis. / 06.2019 / PubMed / Full text
Expression of lipogenic markers is decreased in subcutaneous adipose tissue and adipocytes of older women and is negatively linked to GDF15 expression. / 08.2019 / PubMed / Full text
Effects of a resistance-training programme on endoplasmic reticulum unfolded protein response and mitochondrial functions in PBMCs from elderly subjects. / 08.2019 / PubMed / Full text
[Protective effect of Wuzi Yanzong recipe on testicular germ cell apoptosis in natural ageing rats through endoplasmic reticulum stress]. / 10.2018 / PubMed / Full text
Protective effect of Wuzi Yanzong recipe on testicular dysfunction through inhibition of germ cell apoptosis in ageing rats via endoplasmic reticulum stress. / 03.2019 / PubMed / Full text
Loss of NRF-2 and PGC-1α genes leads to retinal pigment epithelium damage resembling dry age-related macular degeneration. / 01.2019 / PubMed / Full text
Inhibition of glioma growth by flavokawain B is mediated through endoplasmic reticulum stress induced autophagy. / 2018 / PubMed / Full text
De-silencing [i]Grb10[/i] contributes to acute ER stress-induced steatosis in mouse liver. / 05.2018 / PubMed / Full text
Resveratrol modulates response against acute inflammatory stimuli in aged mouse brain. / 02.2018 / PubMed / Full text
Integrated stress response stimulates FGF21 expression: Systemic enhancer of longevity. / 12.2017 / PubMed / Full text

CCR2

Hip Fracture Leads to Transitory Immune Imprint in Older Patients. / 2020 / PubMed / Full text
The CC-chemokine receptor 2 is involved in the control of ovarian folliculogenesis and fertility lifespan in mice. / 09.2020 / PubMed / Full text
Deficit of resolution receptor magnifies inflammatory leukocyte directed cardiorenal and endothelial dysfunction with signs of cardiomyopathy of obesity. / 08.2020 / PubMed / Full text
Tet2-mediated clonal hematopoiesis in nonconditioned mice accelerates age-associated cardiac dysfunction. / 26.03.2020 / PubMed / Full text
Inflammation and Ectopic Fat Deposition in the Aging Murine Liver Is Influenced by CCR2. / 02.2020 / PubMed / Full text
Klotho-mediated targeting of CCL2 suppresses the induction of colorectal cancer progression by stromal cell senescent microenvironments. / 11.2019 / PubMed / Full text
Aging induces cardiac mesenchymal stromal cell senescence and promotes endothelial cell fate of the CD90 + subset. / 10.2019 / PubMed / Full text
Commensal bacteria contribute to insulin resistance in aging by activating innate B1a cells. / 14.11.2018 / PubMed / Full text
Persistent Infiltration and Impaired Response of Peripherally-Derived Monocytes after Traumatic Brain Injury in the Aged Brain. / 30.05.2018 / PubMed / Full text
Cryopreserved whole blood for the quantification of monocyte, T-cell and NK-cell subsets, and monocyte receptor expression by multi-color flow cytometry: A methodological study based on participants from the canadian longitudinal study on aging. / 05.2018 / PubMed / Full text
Inhibition of Radiation-Induced Ccl2 Signaling Protects Lungs from Vascular Dysfunction and Endothelial Cell Loss. / 10.01.2019 / PubMed / Full text
Attenuated Macrophage Infiltration in Glomeruli of Aged Mice Resulting in Ameliorated Kidney Injury in Nephrotoxic Serum Nephritis. / 10.08.2018 / PubMed / Full text

CFI

Psychosocial Resources for Hedonic Balance, Life Satisfaction and Happiness in the Elderly: A Path Analysis. / 06.08.2020 / PubMed / Full text
Validity and Reliability of the Flourishing Scale in a Sample of Older Adults in Iran. / 2020 / PubMed / Full text
The decision about retirement: A scale to describe representations and practices of medical doctors and nurses. / 07-08.2016 / PubMed / Full text
Family versus intimate partners: Estimating who matters more for health in a 20-year longitudinal study. / 03.2020 / PubMed / Full text
Adapting and validating the Rosenberg Self-Esteem Scale for elderly Spanish population. / 02.2020 / PubMed / Full text
Mediating Role of Fall-related Efficacy in a Fall Prevention Program. / 01.03.2019 / PubMed / Full text
An application of Bayesian measurement invariance to modelling cognition over time in the English Longitudinal Study of Ageing. / 12.2018 / PubMed / Full text
[New semantic-cultural validation and psychometric study of the CASP-19 scale in adult and elderly Brazilians]. / 11.10.2018 / PubMed / Full text
Mental status evaluation in older adults with cancer: Development of the Mental Health Index-13. / 03.2019 / PubMed / Full text
The ACTIVE conceptual framework as a structural equation model. / 01-02.2018 / PubMed / Full text
The Utility of the Cognitive Function Instrument (CFI) to Detect Cognitive Decline in Non-Demented Older Adults. / 2017 / PubMed / Full text
The effect of age on the response of retinal capillary filling to changes in intraocular pressure measured by optical coherence tomography angiography. / 01.2018 / PubMed / Full text

DNMT3A

Epigenetic regulation of miR-29a/miR-30c/DNMT3A axis controls SOD2 and mitochondrial oxidative stress in human mesenchymal stem cells. / 09.09.2020 / PubMed / Full text
Collagens and DNA methyltransferases in mare endometrosis. / 09.2019 / PubMed / Full text
Age-related clonal haemopoiesis is associated with increased epigenetic age. / 19.08.2019 / PubMed / Full text
Alcohol Extracts From [i]Ganoderma lucidum[/i] Delay the Progress of Alzheimer's Disease by Regulating DNA Methylation in Rodents. / 2019 / PubMed / Full text
Targeted, Amplicon-Based, Next-Generation Sequencing to Detect Age-Related Clonal Hematopoiesis. / 2019 / PubMed / Full text
Clonal hematopoiesis: Genes and underlying mechanisms in cardiovascular disease development. / 06.2019 / PubMed / Full text
Concise Review: Age-Related Clonal Hematopoiesis: Stem Cells Tempting the Devil. / 09.2018 / PubMed / Full text
Effects of Parental Aging During Embryo Development and Adult Life: The Case of Nothobranchius furzeri. / 04.2018 / PubMed / Full text
Genetic Biomarkers on Age-Related Cognitive Decline. / 2017 / PubMed / Full text
An inflammatory environment containing TNFα favors Tet2-mutant clonal hematopoiesis. / 03.2018 / PubMed / Full text
Sequential acquisition of mutations in myelodysplastic syndromes. / 2017 / PubMed / Full text
How stable is repression of disallowed genes in pancreatic islets in response to metabolic stress? / 2017 / PubMed / Full text

EZH2

Linking gene expression and phenotypic changes in the developmental and evolutionary origins of osteosclerosis in the ribs of bowhead whales (Balaena mysticetus). / 09.2020 / PubMed / Full text
EZH2 is involved in vulnerability to neuroinflammation and depression-like behaviors induced by chronic stress in different aged mice. / 01.07.2020 / PubMed / Full text
A positive feedback loop between EZH2 and NOX4 regulates nucleus pulposus cell senescence in age-related intervertebral disc degeneration. / 2020 / PubMed / Full text
Perinatal exposure to bisphenol A impacts in the mammary gland morphology of adult Mongolian gerbils. / 04.2020 / PubMed / Full text
Long noncoding RNA MALAT1 potentiates growth and inhibits senescence by antagonizing ABI3BP in gallbladder cancer cells. / 07.06.2019 / PubMed / Full text
Epigenetic Co-Deregulation of EZH2/TET1 is a Senescence-Countering, Actionable Vulnerability in Triple-Negative Breast Cancer. / 2019 / PubMed / Full text
Improving Treatment for Myelodysplastic Syndromes Patients. / 25.10.2018 / PubMed / Full text
Aging Suppresses Skin-Derived Circulating SDF1 to Promote Full-Thickness Tissue Regeneration. / 25.09.2018 / PubMed / Full text
Epigallocatechin-3-gallate and BIX-01294 have different impact on epigenetics and senescence modulation in acute and chronic myeloid leukemia cells. / 05.11.2018 / PubMed / Full text
Selective molecular biomarkers to predict biologic behavior in pituitary tumors. / 05.2017 / PubMed / Full text
Regulation of Cellular Senescence by Polycomb Chromatin Modifiers through Distinct DNA Damage- and Histone Methylation-Dependent Pathways. / 27.03.2018 / PubMed / Full text
Region specific knock-out reveals distinct roles of chromatin modifiers in adult neurogenic niches. / 2018 / PubMed / Full text

HGF

Age-related changes in the immunomodulatory effects of human dental pulp derived mesenchymal stem cells on the CD4 T cell subsets. / 19.11.2020 / PubMed / Full text
Hepatocyte growth factor (HGF) and stem cell factor (SCF) maintained the stemness of human bone marrow mesenchymal stem cells (hBMSCs) during long-term expansion by preserving mitochondrial function via the PI3K/AKT, ERK1/2, and STAT3 signaling pathways. / 31.07.2020 / PubMed / Full text
Phenytoin sodium-ameliorated gingival fibroblast aging is associated with autophagy. / 10.2020 / PubMed / Full text
Impaired integrin α /β -mediated hepatocyte growth factor release by stellate cells of the aged liver. / 04.2020 / PubMed / Full text
Evaluation of the biological behaviour of various dental implant abutment materials on attachment and viability of human gingival fibroblasts. / 07.2019 / PubMed / Full text
Characterization of aged rat vocal fold fibroblasts. / 03.2019 / PubMed / Full text
Circulating Vascular Growth Factors and Magnetic Resonance Imaging Markers of Small Vessel Disease and Atrophy in Middle-Aged Adults. / 09.2018 / PubMed / Full text
Assessment of Human Skin Gene Expression by Different Blends of Plant Extracts with Implications to Periorbital Skin Aging. / 26.10.2018 / PubMed / Full text
Hepatocyte growth factor is a potential biomarker for osteoproliferation and osteoporosis in ankylosing spondylitis. / 02.2019 / PubMed / Full text
Human amniotic mesenchymal stem cells improve ovarian function in natural aging through secreting hepatocyte growth factor and epidermal growth factor. / 09.03.2018 / PubMed / Full text
HGF and BFGF Secretion by Human Adipose-Derived Stem Cells Improves Ovarian Function During Natural Aging via Activation of the SIRT1/FOXO1 Signaling Pathway. / 2018 / PubMed / Full text
Cell-size-dependent upregulation of HGF expression in dermal fibroblasts: Impact on human skin connective tissue aging. / 12.2017 / PubMed / Full text

KL

The goddess who spins the thread of life: Klotho, psychiatric stress, and accelerated aging. / 08.2019 / PubMed / Full text
[i]KLOTHO[/i] heterozygosity attenuates [i]APOE4[/i]-related amyloid burden in preclinical AD. / 16.04.2019 / PubMed / Full text
Utilizing Atlas-Based Modeling to Predict Knee Joint Cartilage Degeneration: Data from the Osteoarthritis Initiative. / 03.2019 / PubMed / Full text
Impaired proteostasis in senescent vascular endothelial cells: a perspective on estrogen and oxidative stress in the aging vasculature. / 01.02.2019 / PubMed / Full text
Leukocyte Telomere Length in Patients with Radiographic Knee Osteoarthritis. / 04.2019 / PubMed / Full text
Klotho at the Edge of Alzheimer's Disease and Senile Depression. / 03.2019 / PubMed / Full text
Review and meta-analysis of genetic polymorphisms associated with exceptional human longevity. / 10.2018 / PubMed / Full text
G-395A polymorphism in the promoter region of the KLOTHO gene associates with frailty among the oldest-old. / 30.04.2018 / PubMed / Full text
Protective Effect of Klotho against Ischemic Brain Injury Is Associated with Inhibition of RIG-I/NF-κB Signaling. / 2017 / PubMed / Full text
Changes in expression of klotho affect physiological processes, diseases, and cancer. / 01.2018 / PubMed / Full text
Anti-aging factor, serum alpha-Klotho, as a marker of acute physiological stress, and a predictor of ICU mortality, in patients with septic shock. / 04.2018 / PubMed / Full text
Secreted αKlotho isoform protects against age-dependent memory deficits. / 09.2018 / PubMed / Full text

PAH

Changes in light absorption by brown carbon in soot particles due to heterogeneous ozone aging in a smog chamber. / 11.2020 / PubMed / Full text
Factors associated with pulmonary arterial hypertension (PAH) in systemic sclerosis (SSc). / 09.2020 / PubMed / Full text
Potentially Avoidable Hospitalization among Long-Term Care Insurance Beneficiaries with Dementia. / 09.2020 / PubMed / Full text
Burden of disease at the same limit of exposure to airborne polycyclic aromatic hydrocarbons varies significantly across countries depending on the gap in longevity. / 30.09.2019 / PubMed / Full text
Converging Paths of Pulmonary Arterial Hypertension and Cellular Senescence. / 07.2019 / PubMed / Full text
Furanoflavones pongapin and lanceolatin B blocks the cell cycle and induce senescence in CYP1A1-overexpressing breast cancer cells. / 15.12.2018 / PubMed / Full text
Exposure to Polycyclic Aromatic Hydrocarbons and Accelerated DNA Methylation Aging. / 06.2018 / PubMed / Full text
Arrhythmias in adult patients with congenital heart disease and pulmonary arterial hypertension. / 12.2018 / PubMed / Full text
Reduced bioavailability and plant uptake of polycyclic aromatic hydrocarbons from soil slurry amended with biochars pyrolyzed under various temperatures. / 06.2018 / PubMed / Full text
Early-life exposure to three size-fractionated ultrafine and fine atmospheric particulates in Beijing exacerbates asthma development in mature mice. / 14.03.2018 / PubMed / Full text
Changes of total and freely dissolved polycyclic aromatic hydrocarbons and toxicity of biochars treated with various aging processes. / 06.2018 / PubMed / Full text
Bioaccessibility of PAHs and PAH derivatives in a fuel soot assessed by an in vitro digestive model with absorptive sink: Effects of aging the soot in a soil-water mixture. / 15.02.2018 / PubMed / Full text

TFAM

Late life maintenance and enhancement of functional exercise capacity in low and high responding rats after low intensity treadmill training. / 01.10.2019 / PubMed / Full text
Maternal ageing impairs mitochondrial DNA kinetics during early embryogenesis in mice. / 08.07.2019 / PubMed / Full text
Differences in Liver TFAM Binding to mtDNA and mtDNA Damage between Aged and Extremely Aged Rats. / 27.05.2019 / PubMed / Full text
Photobiomodulation and Coenzyme Q Treatments Attenuate Cognitive Impairment Associated With Model of Transient Global Brain Ischemia in Artificially Aged Mice. / 2019 / PubMed / Full text
[A study on alterations in mitochondrial biological characteristics during cellular senescence of human embryonic lung fibroblasts]. / 06.03.2019 / PubMed / Full text
Changes in Stemness Properties, Differentiation Potential, Oxidative Stress, Senescence and Mitochondrial Function in Wharton's Jelly Stem Cells of Umbilical Cords of Mothers with Gestational Diabetes Mellitus. / 06.2019 / PubMed / Full text
Cycling CD4+ T cells in HIV-infected immune nonresponders have mitochondrial dysfunction. / 01.11.2018 / PubMed / Full text
Increased TFAM binding to mtDNA damage hot spots is associated with mtDNA loss in aged rat heart. / 20.08.2018 / PubMed / Full text
Restoring mitochondrial DNA copy number preserves mitochondrial function and delays vascular aging in mice. / 08.2018 / PubMed / Full text
Sestrin2 prevents age-related intolerance to post myocardial infarction via AMPK/PGC-1α pathway. / 02.2018 / PubMed / Full text
Skeletal muscle from aged American Quarter Horses shows impairments in mitochondrial biogenesis and expression of autophagy markers. / 02.2018 / PubMed / Full text
Dietary supplementation with acetyl-l-carnitine counteracts age-related alterations of mitochondrial biogenesis, dynamics and antioxidant defenses in brain of old rats. / 11.2017 / PubMed / Full text

BRCA1

Epigenome-wide exploratory study of monozygotic twins suggests differentially methylated regions to associate with hand grip strength. / 10.2019 / PubMed / Full text
PML nuclear bodies are recruited to persistent DNA damage lesions in an RNF168-53BP1 dependent manner and contribute to DNA repair. / 06.2019 / PubMed / Full text
Mechanistic link between DNA damage sensing, repairing and signaling factors and immune signaling. / 2019 / PubMed / Full text
Klotho gene polymorphisms are associated with healthy aging and longevity: Evidence from a meta-analysis. / 03.2019 / PubMed / Full text
High expression of the breast cancer susceptibility gene BRCA1 in long-lived termite kings. / 11.10.2018 / PubMed / Full text
The activated DNA double-strand break repair pathway in cumulus cells from aging patients may be used as a convincing predictor of poor outcomes after in vitro fertilization-embryo transfer treatment. / 2018 / PubMed / Full text
Cost effectiveness of population based BRCA1 founder mutation testing in Sephardi Jewish women. / 04.2018 / PubMed / Full text
Replication Stress Shapes a Protective Chromatin Environment across Fragile Genomic Regions. / 04.01.2018 / PubMed / Full text
Faulty BRCA1, BRCA2 genes: how poor is the prognosis? / 10.2017 / PubMed / Full text
Ovarian Aging in Women With BRCA Germline Mutations. / 01.10.2017 / PubMed / Full text
The expected benefit of preventive mastectomy on breast cancer incidence and mortality in BRCA mutation carriers, by age at mastectomy. / 01.2018 / PubMed / Full text

C2

[Effects of resistance training on mitochondrial function in skeletal muscle of aging rats]. / 03.2020 / PubMed / Full text
Structural and functional characterization of Solanum lycopersicum phosphatidylinositol 3-kinase C2 domain. / 03.2020 / PubMed / Full text
Radiological and Clinical Outcomes of Anterior Cervical Discectomy and Fusion in Older Patients: A Comparative Analysis of Young-Old Patients (Ages 65-74 Years) and Middle-Old Patients (Over 75 Years). / 03.2020 / PubMed / Full text
SerThr-PhosphoProteome of Brain from Aged PINK1-KO+A53T-SNCA Mice Reveals pT1928-MAP1B and pS3781-ANK2 Deficits, as Hub between Autophagy and Synapse Changes. / 04.07.2019 / PubMed / Full text
Age-related Changes in Cervical Sagittal Alignment: A Radiographic Analysis. / 01.10.2019 / PubMed / Full text
Age and Sex-Associated Changes of Complement Activity and Complement Levels in a Healthy Caucasian Population. / 2018 / PubMed / Full text
Twenty-year Longitudinal Follow-up MRI Study of Asymptomatic Volunteers: The Impact of Cervical Alignment on Disk Degeneration. / 12.2018 / PubMed / Full text
Dialdehyde cellulose crosslinked poly(vinyl alcohol) hydrogels: Influence of catalyst and crosslinker shelf life. / 15.10.2018 / PubMed / Full text
Trend-analysis of dental hard-tissue conditions as function of tooth age. / 07.2018 / PubMed / Full text
Attenuation of the Niemann-Pick type C2 disease phenotype by intracisternal administration of an AAVrh.10 vector expressing Npc2. / 08.2018 / PubMed / Full text
Repurposing existing drugs for new AMPK activators as a strategy to extend lifespan: a computer-aided drug discovery study. / 04.2018 / PubMed / Full text

CA2

Maintaining Aging Hippocampal Function with Safe and Feasible Shaking Exercise in SAMP10 Mice. / 2020 / PubMed / Full text
One-year Follow-up Study of Hippocampal Subfield Atrophy in Alzheimer's Disease and Normal Aging. / 2019 / PubMed / Full text
Maturation of PNN and ErbB4 Signaling in Area CA2 during Adolescence Underlies the Emergence of PV Interneuron Plasticity and Social Memory. / 29.10.2019 / PubMed / Full text
Early disruption of parvalbumin expression and perineuronal nets in the hippocampus of the Tg2576 mouse model of Alzheimer's disease can be rescued by enriched environment. / 12.2018 / PubMed / Full text
Protracted hippocampal development is associated with age-related improvements in memory during early childhood. / 01.07.2018 / PubMed / Full text
Neurodevelopment and behavior in neonatal OXYS rats with genetically determined accelerated senescence. / 15.02.2018 / PubMed / Full text
Effect of Chronic Administration of Resveratrol on Cognitive Performance during Aging Process in Rats. / 2017 / PubMed / Full text
Time of day but not aging regulates 5-HT receptor binding sites in the hamster hippocampus. / 01.01.2018 / PubMed / Full text
Cytoarchitectonically-driven MRI atlas of nonhuman primate hippocampus: Preservation of subfield volumes in aging. / 05.2019 / PubMed / Full text
Hippocampal sclerosis, hippocampal neuron loss patterns and TDP-43 in the aged population. / 07.2018 / PubMed / Full text
Aging Does Not Affect Axon Initial Segment Structure and Somatic Localization of Tau Protein in Hippocampal Neurons of Fischer 344 Rats. / 07-08.2017 / PubMed / Full text

CCL2

β1 Integrin regulates adult lung alveolar epithelial cell inflammation. / 30.01.2020 / PubMed / Full text
Neuroprotective effects of targeting BET proteins for degradation with dBET1 in aged mice subjected to ischemic stroke. / 07.2019 / PubMed / Full text
Membrane metallo-endopeptidase mediates cellular senescence induced by oncogenic PIK3CA accompanied with pro-tumorigenic secretome. / 01.08.2019 / PubMed / Full text
Isoflurane anesthesia impairs the expression of immune neuromodulators in the hippocampus of aged mice. / 2018 / PubMed / Full text
Melatonin and inflammation-Story of a double-edged blade. / 11.2018 / PubMed / Full text
Defective autophagy in vascular smooth muscle cells enhances cell death and atherosclerosis. / 2018 / PubMed / Full text
Urine Cytokine and Chemokine Levels Predict Urinary Tract Infection Severity Independent of Uropathogen, Urine Bacterial Burden, Host Genetics, and Host Age. / 09.2018 / PubMed / Full text
Infiltrating macrophages contribute to age-related neuroinflammation in C57/BL6 mice. / 07.2018 / PubMed / Full text
Time-Dependent Changes in Local and Serum Levels of Inflammatory Cytokines as Markers for Incised Wound Aging of Skeletal Muscles. / 05.2018 / PubMed / Full text
Age-related pro-inflammatory and pro-angiogenic changes in human aqueous humor. / 2018 / PubMed / Full text
Immune senescence and biomarkers profile of Bambuí aged population-based cohort. / 03.2018 / PubMed / Full text

CIT

Effect of sex on aging-related decline of dopamine transporter in healthy subjects. / 14.10.2020 / PubMed / Full text
The Relationship Between the Striatal Dopaminergic Neuronal and Cognitive Function With Aging. / 2020 / PubMed / Full text
Initial Dietary Protein Intake Influence Muscle Function Adaptations in Older Men and Women Following High-Intensity Interval Training Combined with Citrulline. / 22.07.2019 / PubMed / Full text
I-FP-CIT striatal binding ratios do not decrease significantly with age in older adults. / 06.2019 / PubMed / Full text
Effect of High-Intensity Interval Training Combined with L-Citrulline Supplementation on Functional Capacities and Muscle Function in Dynapenic-Obese Older Adults. / 17.12.2018 / PubMed / Full text
The Six-Item Cognitive Impairment Test Is Associated with Adverse Outcomes in Acutely Hospitalized Older Patients: A Prospective Cohort Study. / 05-08.2018 / PubMed / Full text
Dopaminergic imaging separates normal pressure hydrocephalus from its mimics. / 10.2018 / PubMed / Full text
Lower Cognitive Function in Older Patients with Lower Muscle Strength and Muscle Mass. / 2018 / PubMed / Full text
Citrulline counteracts overweight- and aging-related effects on adiponectin and leptin gene expression in rat white adipose tissue. / 2015 / PubMed / Full text
Overcoming Barriers of Age to Enhance Efficacy of Cancer Immunotherapy: The Clout of the Extracellular Matrix. / 2018 / PubMed / Full text
Validation of the 6-Item Cognitive Impairment Test and the 4AT test for combined delirium and dementia screening in older Emergency Department attendees. / 01.01.2018 / PubMed / Full text

MCC

Multiple chronic conditions and risk of cognitive impairment and dementia among older Americans: findings from the Aging, Demographics, and Memory Study (ADAMS). / 07.07.2020 / PubMed / Full text
Behaviour consistency is a sensitive tool for distinguishing the effects of aging on physical activity. / 01.07.2020 / PubMed / Full text
Burden on Caregivers of Adults with Multiple Chronic Conditions: Intersectionality of Age, Gender, Education level, Employment Status, and Impact on Social Life. / 09.2020 / PubMed / Full text
Using the Technology Acceptance Model to Explore User Experience, Intent to Use, and Use Behavior of a Patient Portal Among Older Adults With Multiple Chronic Conditions: Descriptive Qualitative Study. / 08.04.2019 / PubMed / Full text
Trends in Risk of Limitations in Instrumental Activities of Daily Living Over Age in Older Persons With and Without Multiple Chronic Conditions. / 01.01.2020 / PubMed / Full text
Association between treatment of superficial bladder cancer and 10-year mortality in older adults with multiple chronic conditions. / 01.12.2018 / PubMed / Full text
The AGING Initiative experience: a call for sustained support for team science networks. / 18.05.2018 / PubMed / Full text
Evidence on selection, optimization, and compensation strategies to optimize aging with multiple chronic conditions: A literature review. / 09-10.2018 / PubMed / Full text
Chronic disease burden predicts food insecurity among older adults. / 06.2018 / PubMed / Full text
Differences Between Younger and Older US Adults With Multiple Chronic Conditions. / 07.09.2017 / PubMed / Full text
Prevalence, Correlates, and Time Trends of Multiple Chronic Conditions Among Israeli Adults: Estimates From the Israeli National Health Interview Survey, 2014-2015. / 10.08.2017 / PubMed / Full text

PRL

Mechanism of PRL2 phosphatase-mediated PTEN degradation and tumorigenesis. / 25.08.2020 / PubMed / Full text
Prolactin mitigates deficiencies of retinal function associated with aging. / 01.2020 / PubMed / Full text
A Spontaneous Aggressive ERα+ Mammary Tumor Model Is Driven by Kras Activation. / 06.08.2019 / PubMed / Full text
IGF-1 Gene Therapy as a Potentially Useful Therapy for Spontaneous Prolactinomas in Senile Rats. / 2018 / PubMed / Full text
Assessment of semen quality and fertility in young growing beef bulls exposed to ergot alkaloids. / 15.09.2018 / PubMed / Full text
[Dynamic changes of reproductive hormone levels and related factors in old and middleaged men in health examination]. / 02.2017 / PubMed
Prolactin as a candidate sebotrop(h)ic hormone? / 07.2018 / PubMed / Full text
Dehydroepiandrosterone enhances decidualization in women of advanced reproductive age. / 04.2018 / PubMed / Full text
Chemogenetic Excitation of Accumbens-Projecting Infralimbic Cortical Neurons Blocks Toluene-Induced Conditioned Place Preference. / 07.02.2018 / PubMed / Full text
[Analysis of serum reproductive hormone levels in men with hyperlipemia in the urban area of Shijiazhuang]. / 11.2016 / PubMed
Proteomic profiling of follicle fluids after superstimulation in one-month-old lambs. / 02.2018 / PubMed / Full text

TET2

Non-coding and Loss-of-Function Coding Variants in TET2 are Associated with Multiple Neurodegenerative Diseases. / 07.05.2020 / PubMed / Full text
60 Years of clonal hematopoiesis research: From X-chromosome inactivation studies to the identification of driver mutations. / 03.2020 / PubMed / Full text
DNA methylation instability by BRAF-mediated TET silencing and lifestyle-exposure divides colon cancer pathways. / 16.12.2019 / PubMed / Full text
Clonal haematopoiesis: connecting ageing and inflammation in cardiovascular disease. / 03.2020 / PubMed / Full text
Targeted, Amplicon-Based, Next-Generation Sequencing to Detect Age-Related Clonal Hematopoiesis. / 2019 / PubMed / Full text
Age-related Changes in the Global DNA Methylation Profile of Oligodendrocyte Progenitor Cells Derived from Rat Spinal Cords. / 02.2019 / PubMed / Full text
Clonal hematopoiesis: Genes and underlying mechanisms in cardiovascular disease development. / 06.2019 / PubMed / Full text
Concise Review: Age-Related Clonal Hematopoiesis: Stem Cells Tempting the Devil. / 09.2018 / PubMed / Full text
Hippocampal [i]TET1[/i] and [i]TET2[/i] Expression and DNA Hydroxymethylation Are Affected by Physical Exercise in Aged Mice. / 2018 / PubMed / Full text
An inflammatory environment containing TNFα favors Tet2-mutant clonal hematopoiesis. / 03.2018 / PubMed / Full text
Sequential acquisition of mutations in myelodysplastic syndromes. / 2017 / PubMed / Full text

TREM2

Loss of TREM2 Confers Resilience to Synaptic and Cognitive Impairment in Aged Mice. / 09.12.2020 / PubMed / Full text
Triggering Receptor Expressed on Myeloid Cell 2 R47H Exacerbates Immune Response in Alzheimer's Disease Brain. / 2020 / PubMed / Full text
Knockdown of astrocytic TREM2 in the hippocampus relieves cognitive decline in elderly male mice. / 15.01.2021 / PubMed / Full text
Immune Signaling in Neurodegeneration. / 16.04.2019 / PubMed / Full text
The Triggering Receptor Expressed on Myeloid Cells-2 (TREM-2) as Expression of the Relationship between Microglia and Alzheimer's Disease: A Novel Marker for a Promising Pathway to Explore. / 2019 / PubMed / Full text
TREM2 triggers microglial density and age-related neuronal loss. / 03.2019 / PubMed / Full text
Differential effects of partial and complete loss of TREM2 on microglial injury response and tauopathy. / 02.10.2018 / PubMed / Full text
Whole-Exome Sequencing of an Exceptional Longevity Cohort. / 16.08.2019 / PubMed / Full text
Differential Phagocytic Properties of CD45 Microglia and CD45 Brain Mononuclear Phagocytes-Activation and Age-Related Effects. / 2018 / PubMed / Full text
Microglia and Aging: The Role of the TREM2-DAP12 and CX3CL1-CX3CR1 Axes. / 22.01.2018 / PubMed / Full text
A Tale of Two Genes: Microglial Apoe and Trem2. / 19.09.2017 / PubMed / Full text

BACE1

Electric Stimulation of Neurogenesis Improves Behavioral Recovery After Focal Ischemia in Aged Rats. / 2020 / PubMed / Full text
Disruption of synaptic expression pattern and age-related DNA oxidation in a neuronal model of lead-induced toxicity. / 05.2020 / PubMed / Full text
Age- and sex-dependent profiles of APP fragments and key secretases align with changes in despair-like behavior and cognition in young APPSwe/Ind mice. / 02.04.2019 / PubMed / Full text
Selective reduction of APP-BACE1 activity improves memory via NMDA-NR2B receptor-mediated mechanisms in aged PDAPP mice. / 03.2019 / PubMed / Full text
Temporal Effects of Neuron-specific beta-secretase 1 (BACE1) Knock-in on the Mouse Brain Metabolome: Implications for Alzheimer's Disease. / 15.01.2019 / PubMed / Full text
Removal of p75 Neurotrophin Receptor Expression from Cholinergic Basal Forebrain Neurons Reduces Amyloid-β Plaque Deposition and Cognitive Impairment in Aged APP/PS1 Mice. / 07.2019 / PubMed / Full text
Axonal organization defects in the hippocampus of adult conditional BACE1 knockout mice. / 19.09.2018 / PubMed / Full text
Biliverdin reductase-A impairment links brain insulin resistance with increased Aβ production in an animal model of aging: Implications for Alzheimer disease. / 10.2018 / PubMed / Full text
Effects of senescence and angiotensin II on expression and processing of amyloid precursor protein in human cerebral microvascular endothelial cells. / 15.01.2018 / PubMed / Full text
Neuroprotective potential of high-dose biotin. / 11.2017 / PubMed / Full text

CD40

The Regulatory Status Adopted by Lymph Node Dendritic Cells and T Cells During Healthy Aging Is Maintained During Cancer and May Contribute to Reduced Responses to Immunotherapy. / 2018 / PubMed / Full text
Age-Related Changes on CD40 Promotor Methylation and Immune Gene Expressions in Thymus of Chicken. / 2018 / PubMed / Full text
Macrophage Depletion in Elderly Mice Improves Response to Tumor Immunotherapy, Increases Anti-tumor T Cell Activity and Reduces Treatment-Induced Cachexia. / 2018 / PubMed / Full text
One-Year Consumption of a Mediterranean-Like Dietary Pattern With Vitamin D3 Supplements Induced Small Scale but Extensive Changes of Immune Cell Phenotype, Co-receptor Expression and Innate Immune Responses in Healthy Elderly Subjects: Results From the United Kingdom Arm of the NU-AGE Trial. / 2018 / PubMed / Full text
Membrane-Bound CD40L Promotes Senescence and Initiates Senescence-Associated Secretory Phenotype via NF-κB Activation in Lung Adenocarcinoma. / 2018 / PubMed / Full text
Effects of Immunosenescence on the Lower Expression of Surface Molecules in Neutrophils and Lymphocytes. / 2018 / PubMed / Full text
Aerobic Exercise Protects from Pseudomonas aeruginosa-Induced Pneumonia in Elderly Mice. / 2018 / PubMed / Full text
Elderly dendritic cells respond to LPS/IFN-γ and CD40L stimulation despite incomplete maturation. / 2018 / PubMed / Full text
C-Reactive Protein Impairs Dendritic Cell Development, Maturation, and Function: Implications for Peripheral Tolerance. / 2018 / PubMed / Full text
Immunoglobulin therapy ameliorates the phenotype and increases lifespan in the severely affected dystrophin-utrophin double knockout mice. / 12.2017 / PubMed / Full text

CXCR4

Aging-Related Reduced Expression of CXCR4 on Bone Marrow Mesenchymal Stromal Cells Contributes to Hematopoietic Stem and Progenitor Cell Defects. / 08.2020 / PubMed / Full text
Transfer of a human gene variant associated with exceptional longevity improves cardiac function in obese type 2 diabetic mice through induction of the SDF-1/CXCR4 signalling pathway. / 09.2020 / PubMed / Full text
Stromal Cell-Derived Factor 1 Protects Brain Vascular Endothelial Cells from Radiation-Induced Brain Damage. / 10.10.2019 / PubMed / Full text
A Neutrophil Timer Coordinates Immune Defense and Vascular Protection. / 19.02.2019 / PubMed / Full text
Novel molecular mechanisms for the adaptogenic effects of herbal extracts on isolated brain cells using systems biology. / 15.11.2018 / PubMed / Full text
Reducing CXCR4 Resulted in Impairing Proliferation and Promoting Aging. / 2018 / PubMed / Full text
Targeting junctional adhesion molecule-C ameliorates sepsis-induced acute lung injury by decreasing CXCR4 aged neutrophils. / 12.2018 / PubMed / Full text
Tumor microenvironment in functional adrenocortical adenomas: immune cell infiltration in cortisol-producing adrenocortical adenoma. / 07.2018 / PubMed / Full text
Lower resting and exercise-induced circulating angiogenic progenitors and angiogenic T cells in older men. / 01.03.2018 / PubMed / Full text
Adipose-Derived Mesenchymal Stem Cells from the Elderly Exhibit Decreased Migration and Differentiation Abilities with Senescent Properties. / 09.2017 / PubMed / Full text

ERG

Effect of age and sex on neurodevelopment and neurodegeneration in the healthy eye: Longitudinal functional and structural study in the Long-Evans rat. / 11.2020 / PubMed / Full text
Mice With a Combined Deficiency of Superoxide Dismutase 1 (Sod1), DJ-1 (Park7), and Parkin (Prkn) Develop Spontaneous Retinal Degeneration With Aging. / 03.09.2019 / PubMed / Full text
Test-retest repeatability of the pattern electroretinogram and flicker electroretinogram. / 12.2019 / PubMed / Full text
Regeneration of Dopaminergic Neurons in Adult Zebrafish Depends on Immune System Activation and Differs for Distinct Populations. / 12.06.2019 / PubMed / Full text
Sirt3 mediates the protective effect of hydrogen in inhibiting ROS-induced retinal senescence. / 01.05.2019 / PubMed / Full text
Further Characterization of the Predominant Inner Retinal Degeneration of Aging Cln3 Knock-In Mice. / 2018 / PubMed / Full text
Two novel forms of ERG oscillation in Drosophila: age and activity dependence. / 03-06.2018 / PubMed / Full text
Loss of XBP1 accelerates age-related decline in retinal function and neurodegeneration. / 04.04.2018 / PubMed / Full text
The Complement System Is Critical in Maintaining Retinal Integrity during Aging. / 2018 / PubMed / Full text
EDI OCT evaluation of choroidal thickness in Stargardt disease. / 2018 / PubMed / Full text

F3

A Comprehensive Analysis of Age and Gender Effects in European Portuguese Oral Vowels. / 05.12.2020 / PubMed / Full text
Prenatal exposure to an environmentally relevant phthalate mixture accelerates biomarkers of reproductive aging in a multiple and transgenerational manner in female mice. / 28.10.2020 / PubMed / Full text
Combining Frontal Transcranial Direct Current Stimulation With Walking Rehabilitation to Enhance Mobility and Executive Function: A Pilot Clinical Trial. / 18.08.2020 / PubMed / Full text
Multigenerational exposure to TiO nanoparticles in soil stimulates stress resistance and longevity of survived C. elegans via activating insulin/IGF-like signaling. / 08.2020 / PubMed / Full text
Co-expression network analysis identified hub genes critical to triglyceride and free fatty acid metabolism as key regulators of age-related vascular dysfunction in mice. / 12.09.2019 / PubMed / Full text
Transgenerational Effects of Extended Dauer Diapause on Starvation Survival and Gene Expression Plasticity in [i]Caenorhabditis elegans[/i]. / 09.2018 / PubMed / Full text
Influence of Supplemental Protein on the Life Expectancy and Reproduction of the Chinese Citrus Fruit Fly, Bactrocera minax (Enderlein) (Tetradacus minax) (Diptera: Tephritidae). / 01.03.2018 / PubMed / Full text
Early-life exposure to three size-fractionated ultrafine and fine atmospheric particulates in Beijing exacerbates asthma development in mature mice. / 14.03.2018 / PubMed / Full text
Multigenerational effects of 4-methylbenzylidene camphor (4-MBC) on the survival, development and reproduction of the marine copepod Tigriopus japonicus. / 01.2018 / PubMed / Full text
Effects of Aging on Vocal Fundamental Frequency and Vowel Formants in Men and Women. / 09.2018 / PubMed / Full text

GAL

Overexpression of Pitx1 attenuates the senescence of chondrocytes from osteoarthritis degeneration cartilage-A self-controlled model for studying the etiology and treatment of osteoarthritis. / 02.2020 / PubMed / Full text
β-Caryophyllene Reduces DNA Oxidation and the Overexpression of Glial Fibrillary Acidic Protein in the Prefrontal Cortex and Hippocampus of d-Galactose-Induced Aged BALB/c Mice. / 05.2020 / PubMed / Full text
Senescence-associated β-galactosidase activity in the developing avian retina. / 09.2019 / PubMed / Full text
Zeaxanthin Isolated from [i]Dunaliella salina[/i] Microalgae Ameliorates Age Associated Cardiac Dysfunction in Rats through Stimulation of Retinoid Receptors. / 14.05.2019 / PubMed / Full text
Effects of sulforaphane on D-galactose-induced liver aging in rats: Role of keap-1/nrf-2 pathway. / 15.07.2019 / PubMed / Full text
MYC and RAS are unable to cooperate in overcoming cellular senescence and apoptosis in normal human fibroblasts. / 2018 / PubMed / Full text
Manipulation of molecular pathways and senescence hallmarks by natural compounds in fibroblast cells. / 04.2019 / PubMed / Full text
Ellagic acid reveals promising anti-aging effects against d-galactose-induced aging on human neuroblastoma cell line, SH-SY5Y: A mechanistic study. / 12.2018 / PubMed / Full text
Molecular and biochemical evidence on the protective role of ellagic acid and silybin against oxidative stress-induced cellular aging. / 04.2018 / PubMed / Full text
Hyperphosphatemia induces senescence in human endothelial cells by increasing endothelin-1 production. / 12.2017 / PubMed / Full text

GSC

[i]mastermind[/i] regulates niche ageing independently of the [i]Notch[/i] pathway in the [i]Drosophila[/i] ovary. / 29.11.2019 / PubMed / Full text
Germline stem cell homeostasis. / 2019 / PubMed / Full text
Endocrine regulation of female germline stem cells in the fruit fly Drosophila melanogaster. / 02.2019 / PubMed / Full text
Generation of Inducible Gene-Switched GAL4 Expressed in the [i]Drosophila[/i] Female Germline Stem Cell Niche. / 05.06.2019 / PubMed / Full text
YAP/Yorkie in the germline modulates the age-related decline of germline stem cells and niche cells. / 2019 / PubMed / Full text
Diminished Jak/STAT Signaling Causes Early-Onset Aging Defects in Stem Cell Cytokinesis. / 21.01.2019 / PubMed / Full text
JNK signaling triggers spermatogonial dedifferentiation during chronic stress to maintain the germline stem cell pool in the [i]Drosophila[/i] testis. / 09.07.2018 / PubMed / Full text
Age-related differences in BOLD modulation to cognitive control costs in a multitasking paradigm: Global switch, local switch, and compatibility-switch costs. / 15.05.2018 / PubMed / Full text
Modelling glioblastoma tumour-host cell interactions using adult brain organotypic slice co-culture. / 22.02.2018 / PubMed / Full text
Loss of [i]foxo[/i] rescues stem cell aging in [i]Drosophila[/i] germ line. / 19.09.2017 / PubMed / Full text

IRS1

MicroRNA-34a causes ceramide accumulation and effects insulin signaling pathway by targeting ceramide kinase (CERK) in aging skeletal muscle. / 06.2020 / PubMed / Full text
Longevity in response to lowered insulin signaling requires glycine N-methyltransferase-dependent spermidine production. / 01.2020 / PubMed / Full text
Serine Phosphorylation of IRS1 Correlates with Aβ-Unrelated Memory Deficits and Elevation in Aβ Level Prior to the Onset of Memory Decline in AD. / 17.08.2019 / PubMed / Full text
Involvement of insulin receptor substrates in cognitive impairment and Alzheimer's disease. / 08.2019 / PubMed / Full text
The senescent status of endothelial cells affects proliferation, inflammatory profile and SOX2 expression in bone marrow-derived mesenchymal stem cells. / 06.2019 / PubMed / Full text
Fucoidan⁻Fucoxanthin Ameliorated Cardiac Function via IRS1/GRB2/ SOS1, GSK3β/CREB Pathways and Metabolic Pathways in Senescent Mice. / 21.01.2019 / PubMed / Full text
Therapeutic and preventive effects of exercise on cardiometabolic parameters in aging and obese rats. / 02.2019 / PubMed / Full text
Common and unique transcriptional responses to dietary restriction and loss of insulin receptor substrate 1 (IRS1) in mice. / 20.05.2018 / PubMed / Full text
Small nucleoli are a cellular hallmark of longevity. / 30.08.2017 / PubMed / Full text
An alternative model for studying age-associated metabolic complications: Senescence-accelerated mouse prone 8. / 01.12.2017 / PubMed / Full text

KLF4

Extracellular Vesicles from Healthy Cells Improves Cell Function and Stemness in Premature Senescent Stem Cells by miR-302b and HIF-1α Activation. / 25.06.2020 / PubMed / Full text
Soluble klotho regulates the function of salivary glands by activating KLF4 pathways. / 02.10.2019 / PubMed / Full text
Centenarians Overexpress Pluripotency-Related Genes. / 16.08.2019 / PubMed / Full text
A SIRT1-centered circuitry regulates breast cancer stemness and metastasis. / 12.2018 / PubMed / Full text
miR-10a rejuvenates aged human mesenchymal stem cells and improves heart function after myocardial infarction through KLF4. / 30.05.2018 / PubMed / Full text
MYC Releases Early Reprogrammed Human Cells from Proliferation Pause via Retinoblastoma Protein Inhibition. / 10.04.2018 / PubMed / Full text
Kruppel-like factor 4 regulates keratinocyte senescence. / 05.05.2018 / PubMed / Full text
Role of CD133 Molecule in Wnt Response and Renal Repair. / 03.2018 / PubMed / Full text
Coupling shRNA screens with single-cell RNA-seq identifies a dual role for mTOR in reprogramming-induced senescence. / 15.10.2017 / PubMed / Full text
ZSCAN10 expression corrects the genomic instability of iPSCs from aged donors. / 09.2017 / PubMed / Full text

MPI

Age-related decline of lymphatic drainage from the eye: A noninvasive in vivo photoacoustic tomography study. / 05.2020 / PubMed / Full text
Interest of the multidimensional prognostic index (MPI) as an assessment tool in hospitalized patients in geriatrics. / 01.12.2019 / PubMed / Full text
Reducing Potentially Inappropriate Medications in Older Adults: A Way Forward. / 12.2019 / PubMed / Full text
The prognostic significance of geriatric syndromes and resources. / 01.2020 / PubMed / Full text
[Polypharmacy and associated factors in elderly diabetic]. / 05-06.2018 / PubMed / Full text
An examination of the concordance between self-reported collisions, driver records, and insurance claims in older drivers. / 12.2018 / PubMed / Full text
Age Modifies the Association of Dietary Protein Intake with All-Cause Mortality in Patients with Chronic Kidney Disease. / 13.11.2018 / PubMed / Full text
New associations of the Multidimensional Prognostic Index. / 08.2019 / PubMed / Full text
Effects of oral amino acid supplementation on Multidimensional Prognostic Index in hospitalized older patients: a multicenter randomized, double-blind, placebo-controlled pilot study. / 2018 / PubMed / Full text
Degree of Peripheral Thyroxin Deiodination, Frailty, and Long-Term Survival in Hospitalized Older Patients. / 01.05.2018 / PubMed / Full text

NAMPT

Over-expression of Nicotinamide phosphoribosyltransferase in mouse cells confers protective effect against oxidative and ER stress-induced premature senescence. / 08.2020 / PubMed / Full text
Resistance training increases muscle NAD and NADH concentrations as well as NAMPT protein levels and global sirtuin activity in middle-aged, overweight, untrained individuals. / 05.05.2020 / PubMed / Full text
Differential Expression of Human N-Alpha-Acetyltransferase 40 (hNAA40), Nicotinamide Phosphoribosyltransferase (NAMPT) and Sirtuin-1 (SIRT-1) Pathway in Obesity and T2DM: Modulation by Metformin and Macronutrient Intake. / 2019 / PubMed / Full text
Aerobic and resistance exercise training reverses age-dependent decline in NAD salvage capacity in human skeletal muscle. / 07.2019 / PubMed / Full text
Extracellular Vesicle-Contained eNAMPT Delays Aging and Extends Lifespan in Mice. / 06.08.2019 / PubMed / Full text
lncRNA GAS5/miR-223/NAMPT axis modulates the cell proliferation and senescence of endothelial progenitor cells through PI3K/AKT signaling. / 09.2019 / PubMed / Full text
Aged Nicotinamide Riboside Kinase 2 Deficient Mice Present an Altered Response to Endurance Exercise Training. / 2018 / PubMed / Full text
Loss of NAMPT in aging retinal pigment epithelium reduces NAD availability and promotes cellular senescence. / 12.06.2018 / PubMed / Full text
Nicotinamide phosphoribosyltransferase delays cellular senescence by upregulating SIRT1 activity and antioxidant gene expression in mouse cells. / 12.2017 / PubMed / Full text
Deletion of Nampt in Projection Neurons of Adult Mice Leads to Motor Dysfunction, Neurodegeneration, and Death. / 29.08.2017 / PubMed / Full text

PSD

Quantitative Immunoblotting Analyses Reveal that the Abundance of Actin, Tubulin, Synaptophysin and EEA1 Proteins is Altered in the Brains of Aged Mice. / 21.08.2020 / PubMed / Full text
Exercise Attenuates Brain Aging by Rescuing Down-Regulated Wnt/β-Catenin Signaling in Aged Rats. / 2020 / PubMed / Full text
Concurrent nicotine exposure to prenatal alcohol consumption alters the hippocampal and cortical neurotoxicity. / 01.2020 / PubMed / Full text
The Experience of Family Physicians and Home Health Staff Involved in an Intervention to Increase Patient-Related Collaboration. / 12.2019 / PubMed / Full text
Pterostilbene Improves Cognitive Performance in Aged Rats: An in Vivo Study. / 2019 / PubMed / Full text
Higher Levels of Protein Palmitoylation in the Frontal Cortex across Aging Were Associated with Reference Memory and Executive Function Declines. / 01-02.2019 / PubMed / Full text
A single cocaine administration alters dendritic spine morphology and impairs glutamate receptor synaptic retention in the medial prefrontal cortex of adolescent rats. / 15.09.2018 / PubMed / Full text
Differential effects of adolescent and adult-initiated voluntary exercise on context and cued fear conditioning. / 02.2019 / PubMed / Full text
Dynamic SAP102 expression in the hippocampal subregions of rats and APP/PS1 mice of various ages. / 06.2018 / PubMed / Full text
Downregulated Nuclear Factor E2-Related Factor 2 (Nrf2) Aggravates Cognitive Impairments via Neuroinflammation and Synaptic Plasticity in the Senescence-Accelerated Mouse Prone 8 (SAMP8) Mouse: A Model of Accelerated Senescence. / 23.02.2018 / PubMed / Full text

REST

[Brain and Neuronal Aging: Aged Brain Controls via Gene Expression Fidelity and Master Regulatory Factors]. / 2020 / PubMed / Full text
Effect of 9 - PAHSA on cognitive dysfunction in diabetic mice and its possible mechanism. / 09.04.2020 / PubMed / Full text
Increased REST to Optimize Life Span? / 12.2019 / PubMed / Full text
Cardiac baroreflex hysteresis is one of the determinants of the heart period variability asymmetry. / 01.10.2019 / PubMed / Full text
Pterostilbene Improves Cognitive Performance in Aged Rats: An in Vivo Study. / 2019 / PubMed / Full text
Comparison between probabilistic and Wiener-Granger causality in assessing modifications of the cardiac baroreflex control with age. / 22.10.2018 / PubMed / Full text
Fast-Evolving Human-Specific Neural Enhancers Are Associated with Aging-Related Diseases. / 23.05.2018 / PubMed / Full text
Influence of age and gender on the phase and strength of the relation between heart period and systolic blood pressure spontaneous fluctuations. / 01.03.2018 / PubMed / Full text
Genetic Biomarkers on Age-Related Cognitive Decline. / 2017 / PubMed / Full text
MicroRNA Expression Analysis of Centenarians and Rheumatoid Arthritis Patients Reveals a Common Expression Pattern. / 2017 / PubMed / Full text

SIRT2

Melatonin ameliorates the advanced maternal age-associated meiotic defects in oocytes through the SIRT2-dependent H4K16 deacetylation pathway. / 24.01.2020 / PubMed / Full text
SIRT2 functions in aging, autophagy, and apoptosis in post-maturation bovine oocytes. / 01.09.2019 / PubMed / Full text
Lifelong Football Training: Effects on Autophagy and Healthy Longevity Promotion. / 2019 / PubMed / Full text
Mitochondrial Stress-Initiated Aberrant Activation of the NLRP3 Inflammasome Regulates the Functional Deterioration of Hematopoietic Stem Cell Aging. / 22.01.2019 / PubMed / Full text
Hsp90 Stabilizes SIRT1 Orthologs in Mammalian Cells and [i]C. elegans[/i]. / 20.11.2018 / PubMed / Full text
Tenovin-1 Induces Senescence and Decreases Wound-Healing Activity in Cultured Rat Primary Astrocytes. / 01.05.2019 / PubMed / Full text
High expression of CPT1b in skeletal muscle in metabolically healthy older subjects. / 04.2019 / PubMed / Full text
Expression of Sirtuins in the Retinal Neurons of Mice, Rats, and Humans. / 2017 / PubMed / Full text
Loss of SIRT2 leads to axonal degeneration and locomotor disability associated with redox and energy imbalance. / 12.2017 / PubMed / Full text
SIRT2 Acts as a Cardioprotective Deacetylase in Pathological Cardiac Hypertrophy. / 21.11.2017 / PubMed / Full text

TLR2

Changes in salivary microbial sensing proteins CD14 and TLR2 with aging. / 07.2020 / PubMed / Full text
Culture Model for Non-human Primate Choroid Plexus. / 2019 / PubMed / Full text
Changes in fetal membrane histology with cervical insufficiency and transabdominal cerclage. / 08.2019 / PubMed / Full text
Aging leads to dysfunctional innate immune responses to TLR2 and TLR4 agonists. / 09.2019 / PubMed / Full text
The Synergy of Aging and LPS Exposure in a Mouse Model of Parkinson's Disease. / 10.2018 / PubMed / Full text
Aging modulates microglia phenotypes in neuroinflammation of MPTP-PD mice. / 01.10.2018 / PubMed / Full text
Toll-like receptor 2 deficiency hyperactivates the FoxO1 transcription factor and induces aging-associated cardiac dysfunction in mice. / 24.08.2018 / PubMed / Full text
Cryopreserved whole blood for the quantification of monocyte, T-cell and NK-cell subsets, and monocyte receptor expression by multi-color flow cytometry: A methodological study based on participants from the canadian longitudinal study on aging. / 05.2018 / PubMed / Full text
TLR4 and TLR2 activation is differentially associated with age during Parkinson's disease. / 01.2018 / PubMed / Full text
Role of pattern recognition receptors of the neurovascular unit in inflamm-aging. / 01.11.2017 / PubMed / Full text

UCP1

Muscle-dependent regulation of adipose tissue function in long-lived growth hormone-mutant mice. / 28.05.2020 / PubMed / Full text
Lack of UCP1 stimulates fatty liver but mediates UCP1-independent action of beige fat to improve hyperlipidemia in Apoe knockout mice. / 01.07.2020 / PubMed / Full text
Postnatal leptin surge is critical for the transient induction of the developmental beige adipocytes in mice. / 01.04.2020 / PubMed / Full text
Age-related sex differences in the expression of important disease-linked mitochondrial proteins in mice. / 05.12.2019 / PubMed / Full text
An anti-inflammatory phenotype in visceral adipose tissue of old lean mice, augmented by exercise. / 19.08.2019 / PubMed / Full text
Brown and Beige Adipose Tissue and Aging. / 2019 / PubMed / Full text
Resveratrol and HIV-protease inhibitors control UCP1 expression through opposite effects on p38 MAPK phosphorylation in human adipocytes. / 02.2020 / PubMed / Full text
Circulating factors present in the sera of naturally skinny people may influence cell commitment and adipocyte differentiation of mesenchymal stromal cells. / 26.03.2019 / PubMed / Full text
Assessment of the Aging of the Brown Adipose Tissue by F-FDG PET/CT Imaging in the Progeria Mouse Model Lmna . / 2018 / PubMed / Full text
Inactivation of the E3 Ubiquitin Ligase IDOL Attenuates Diet-Induced Obesity and Metabolic Dysfunction in Mice. / 08.2018 / PubMed / Full text