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...[DYRK3]] promote cell survival through phosphorylation and activation of [[SIRT1]]. ...ptotic DYRK members promote cell survival through direct modification of [[SIRT1]]. These findings may have important implications in understanding the mole ...

|title=A [[SIRT1]]-centered circuitry regulates breast cancer stemness and metastasis. ...to Paclitaxel and improves therapeutic effects. Our findings delineate a [[SIRT1]]-centered circuitry that regulates CSC origination, and targeting this pat ...

|title=Endothelial [[SIRT1]] prevents adverse arterial remodeling by facilitating [[HERC2]]-mediated d ...trol.Conclusion-By downregulating acetylated LKB1 protein via [[HERC2]], [[SIRT1]] fine-tunes the crosstalk between endothelial and vascular smooth muscle c ...

...tion delays senescence and promotes proliferation of HUVECs via the AMPK/[[SIRT1]]-[[FOXA3]]-Beclin1 pathway. ...inhibit senescence, and enhance proliferation of HUVECs through the AMPK/[[SIRT1]]-[[FOXA3]]-Beclin1 pathway. ...

...e and function of EPCs through the VEGF/[[KDR]] pathway by activation of [[SIRT1]]. |keywords=* SIRT1 ...

...by the [[CCAR2]] ortholog, CCAR-1. This negative regulation requires the [[SIRT1]] homolog SIR-2.1. In addition, knockdown of CCAR-1 via ccar-1 RNAi works t ...

|title=[[SIRT1]] protects cochlear hair cell and delays age-related hearing loss via autop ...n elucidating the link between ER stress and autophagy in aging. Because [[SIRT1]] activation restores autophagy with reduced HC death and hearing loss, it ...

...cid acts on NRF2 expression, and in turn to the actions of GRα, [[GDF11]], Sirt1, and Sirt6. Regarding the increased expression of Per1, the activation effe ...

|title=Tumor suppressor [[HIC1]] directly regulates [[SIRT1]] to modulate p53-dependent DNA-damage responses. ...c silencing of [[HIC1]], we speculate that the resultant upregulation of [[SIRT1]] may be a double-edged sword that both promotes survival of aging cells an ...

.... The three down-regulated mRNA in cellular aging, [[ELK1]], [[FOS]] and [[SIRT1]], were increased with tocotrienol-rich fraction treatment. Expression of [ ...

...e and function of EPCs through the VEGF/[[KDR]] pathway by activation of [[SIRT1]]. |keywords=* SIRT1 ...

...ression of p21, PAI-1, and K382 acetylation of p53 as well as reduction of Sirt1. The knockdown of TRG5 abolished the protective role of INT-777 on these mo * Sirt1 ...

...rucial mediator in the renal aging process. Furthermore, manipulation of [[SIRT1]] activity by NMN seems to be a potential pharmaceutical intervention for A * SIRT1 ...

...iR-302b-3p inhibitor could delay skin fibroblast senescence and contribute Sirt1 expression. In addition, we demonstrated that c-Jun N-terminal kinase 2(JNK ...

...rlying mechanism remains elusive. Here, we report that Sirtinol, a known [[SIRT1]] inhibitor, induces premature senescence and growth arrest in K562 CML cel * SIRT1 ...

...ting the intracellular Sirt1-FOXO3a-[[SOD2]] axis. Moreover, the inhibited Sirt1 expression was related to the decreased mitochondrial function and the lowe ...

...erum deprivation and high confluency caused nuclear translocation of the [[SIRT1]]-regulated transcription factor FOXO3a. Our data indicate resveratrol's ac ...

|title=Dexamethasone downregulates [[SIRT1]] and [[IL6]] and upregulates [[EDN1]] genes in stem cells derived from gin ...]] was increased. Application of dexamethasone reduced the expression of [[SIRT1]] and [[IL6]] but enhanced the expression of [[EDN1]] of stem cells. ...

...s. The expression levels of Ac-histone H3, [[HDAC1]], [[HAT1]], p300 and [[SIRT1]] were increased in HT1080 cells treated with spermine. In addition, the ex * SIRT1 ...

...hylation of H3K79 (H3K79me3). Treatment of cells with either siAMPK or si[[SIRT1]] repressed [[DOT1L]]-mediated enhancement of H3K79me3. Moreover, the incre ...

...from hepatitis C virus infection-associated senescence via ΔNp63-miR-181a-Sirt1 pathway. ...umber of Foxp3 effector T (T ) cells upon manipulating the ΔNp63-miR-181a-Sirt1 pathway. In conclusion, these findings provide novel mechanistic insights i ...

.... IGF-I levels were lower in RasGrf1(-/-) than in controls. Furthermore, [[SIRT1]] expression was increased in RasGrf1(-/-) animals. Consistent with this, t ...

.... In addition, 64 SNPs loci distributed in 13 candidate genes [[FOXO3]], [[SIRT1]], [[TOMM40]], [[APOE]], [[PICALM]], [[COMT]], [[CETP]], [[CLU]], [[CR1]], ...

...[[DLC1]] promoted senescence through FoxO3a/NF-κB signaling mediated by [[SIRT1]] after resveratrol treatment. Finally, resveratrol increased ROS productio * SIRT1 ...

...levels) in parallel to decreased H S production and rejuvenation (LC3 and SIRT1)-related gene expression. In addition, [[CBS]] gene KD in ASC52telo cells r ...

...with antibodies for p21, p16, and β-galactosidase (senescence); for LC3, [[SIRT1]], [[MAP1S]], and pAMKα (autophagy); and for LDH and GLUT1 (metabolism). E ...

* SIRT1 |title=Negative reciprocal regulation between Sirt1 and Per2 modulates the circadian clock and aging. ...

...s, Cyclin A2, Cyclin D1, [[CDK2]], [[CDK6]], [[ETS1]], [[NBN]], [[RB1]], [[SIRT1]], were down-regulated. The increase in cyclin-dependent kinase inhibitors ...

...abolism. EGCG significantly increased the protein expression of [[FOXO1]], Sirt1, [[CAT]], [[FABP1]], [[GSTA2]], [[ACSL1]] and [[CPT2]] but significantly de ...

...es treated with the NAD [[SIRT1]] cofactor, than in cells treated with a [[SIRT1]] inhibitor. Inhibition of importin β by importazole maintained [[SOX9]] i * SIRT1 ...

...myocardial contractile function with adaptive cardiac remodeling: role of Sirt1-mediated autophagy regulation. ...ctile dysfunction and loss of mitophagy were improved by rapamycin and the Sirt1 activator SRT1720. Activation of Akt using insulin or Parkin deficiency pre ...

...ed galactosidase, beta 1; SASP: senescence-associated secretory phenotype; SIRT1: sirtuin 1; Spautin 1: specific and potent autophagy inhibitor 1; [[SQSTM1] ...ated changes in cathepsin D levels in humans and the association between [[SIRT1]] and eNOS. ...

...rotein kinases and other factors, such as mTOR, [[ULK1]], [[HDAC5]], and [[SIRT1]]. Given that AMPK and HIF activation can enhance not only healthspan and l ...el of NAD( ). NAD( ) is a substrate for nuclear sirtuins, especially for [[SIRT1]] and [[SIRT6]], which deacetylate histones and transcription factors, e.g. ...

...the 4 potential candidate genes [[ETV1]], [[ONECUT1]], [[MACROD2]], and [[SIRT1]], which directly (via disease resistance mechanisms) or indirectly (via mi ...

|title=[[SIRT1]] - a new mammalian substrate of nuclear autophagy. ...er substrate of nuclear autophagy and suggests a new strategy to promote [[SIRT1]]-mediated health benefits by suppressing its autophagic degradation. ...

|title=Loss-of-[[SIRT1]] function during vascular ageing: hyperphosphorylation mediated by cyclin- ...[[SIRT1]] function during vascular ageing. Thus, by inhibiting [[CDK5]], [[SIRT1]] function can be improved, in turn preventing the development of atheroscl ...

...se receiving the LP diet. Furthermore, [[HP]] feeding increased relative [[SIRT1]] mRNA levels. Additional mechanistic cell culture experiments were perform ...

...by the [[CCAR2]] ortholog, CCAR-1. This negative regulation requires the [[SIRT1]] homolog SIR-2.1. In addition, knockdown of CCAR-1 via ccar-1 RNAi works t ...Fs and Hsps in skeletal muscle. We studied the protein levels of sirtuins (SIRT1, [[SIRT2]], [[SIRT3]], [[SIRT4]], [[SIRT5]], [[SIRT6]] and SIRT7), [[HSF1]] ...

...at melatonin may help the hippocampal neuronal homeostasis by increasing [[SIRT1]], [[FOXO1]] and melatonin receptors expression while decreasing [[DKK1]] e ...

...and BAT weight). In addition, mitochondrial biogenesis proteins (PGC-1α, [[SIRT1]], and pAMPK) and respiratory chain activity (complexes I, II/III, III, and ...

...production of melanin were investigated. Enzymatic activity of sirtuin 1 (SIRT1) after treatment with PTP20 was also determined. Ex vivo studies using huma ...

...on of senescence-associated beta-galactosidase, and loss of phosphorylated Sirt1 . Furthermore, we also demonstrate that JQ1 was efficient in reducing the p ...

...abolism. EGCG significantly increased the protein expression of [[FOXO1]], Sirt1, [[CAT]], [[FABP1]], [[GSTA2]], [[ACSL1]] and [[CPT2]] but significantly de ...

...of NAD. On the other hand, NGD and NHD cannot be used as substrates for [[SIRT1]], [[SIRT3]], and [[PARP1]]. These results reveal the basic metabolism of N ...progenitor cells by preserving intracellular NAD levels and increasing [[SIRT1]] activity. ...

...ed galactosidase, beta 1; SASP: senescence-associated secretory phenotype; SIRT1: sirtuin 1; Spautin 1: specific and potent autophagy inhibitor 1; [[SQSTM1] ...

...on tumorigenesis has yet to be elucidated. Previous studies focusing on [[SIRT1]], do not support a critical role for this sirtuin family member in CR-medi |title=Hsp90 Stabilizes [[SIRT1]] Orthologs in Mammalian Cells and [i]C. elegans[/i]. ...

...[[FEN1]], [[DNA2]], RecQ helicases, Top2α, Top2β, [[TOP3A]], DNMT1/3a/3b, SIRT1). In addition, specialized telomeric proteins, such as [[TERT]] (telomerase ...

...pophagy and senescence. Taken together, our findings demonstrate a novel [[SIRT1]]/[[LAMP1]]/lipophagy axis mediating AGG-induced senescence in prostate can * SIRT1 ...

...PER, [[CLOCK]], BMAL1, ROR, and clock-controlled proteins like [[AVP]], [[SIRT1]], FOXO, and PK2 towards future approaches for management of AD. Furthermor |title=[[SIRT1]] mediates central circadian control in the SCN by a mechanism that decays ...

...tive aging and glucose overload can be prevented by optimizing the Nampt-[[SIRT1]] axis. ...

...Fs and Hsps in skeletal muscle. We studied the protein levels of sirtuins (SIRT1, [[SIRT2]], [[SIRT3]], [[SIRT4]], [[SIRT5]], [[SIRT6]] and SIRT7), [[HSF1]] ...

...abolism. EGCG significantly increased the protein expression of [[FOXO1]], Sirt1, [[CAT]], [[FABP1]], [[GSTA2]], [[ACSL1]] and [[CPT2]] but significantly de ...ere and telomerase, PPAR-α, GLUTs, [[FOXO1]], caspase-3, bcl-2, along with SIRT1/AMPK, PI3K/Akt, NF-κB, and insulin/insulin-like growth factor-1 pathways a ...

...s, Cyclin A2, Cyclin D1, [[CDK2]], [[CDK6]], [[ETS1]], [[NBN]], [[RB1]], [[SIRT1]], were down-regulated. The increase in cyclin-dependent kinase inhibitors ...

...s with SEN sEVs induced a miR-21/miR-217-related impairment of [[DNMT1]]-[[SIRT1]] expression, the reduction of proliferation markers, the acquisition of a * SIRT1 ...

...[[FEN1]], [[DNA2]], RecQ helicases, Top2α, Top2β, [[TOP3A]], DNMT1/3a/3b, SIRT1). In addition, specialized telomeric proteins, such as [[TERT]] (telomerase ...

...[[FGFR4]] signaling-activated PDAC cells. Furthermore, downregulation of [[SIRT1]] and [[SIRT6]] by BLU9931 contributed to senescence induction, priming the ...

...binding, ERK 1/2 activation, IL-8 release and mRNA levels but decreased [[SIRT1]], [[HDAC2]], [[HDAC3]] and FoxO3 nuclear expression. Combined therapy with ...

...erine-threonine kinase(Akt)/mTOR,the AMPK/silent information regulation 1 (Sirt1) and transforming growth factor β (TGF-β) play the important roles in ren ...

...abolism. EGCG significantly increased the protein expression of [[FOXO1]], Sirt1, [[CAT]], [[FABP1]], [[GSTA2]], [[ACSL1]] and [[CPT2]] but significantly de ...

...sms and pathways that are associated with the neuroprotective effects of [[SIRT1]]. ...is devastating condition. On the other hand, therapeutic upregulation of [[SIRT1]] might provide opportunities for the amelioration of Alzheimer's-disease-t ...

...by accelerated aging-related mechanisms. Sirtuins (SIRTs), particularly [[SIRT1]], [[SIRT3]], and [[SIRT6]], are well-known mediators of aging; however, li ...

...enoside Rg1 protects against Sca-1 HSC/HPC cell aging by regulating the [[SIRT1]]-[[FOXO3]] and [[SIRT3]]-[[SOD2]] signaling pathways in a γ-ray irradiati ...s age‑associated alterations and improves cardiac function by increasing [[SIRT1]] and [[SIRT3]] expression. ...

|title=[[SIRT1]] affects DNA methylation of polycomb group protein target genes, a hotspot ...genome, but particularly at PCGTs. Although the mechanism through which [[SIRT1]] has these effects is yet to be uncovered, this action is likely to contri ...

...ng; [[AMH]] level; estrous cycle; mTOR activity; [[GDF9]], [[BMP15]], LHR, Sirt1, and Cyp19a level; ROS and annexin V level; [[IL6]] and adiponectin level; ...

...by accelerated aging-related mechanisms. Sirtuins (SIRTs), particularly [[SIRT1]], [[SIRT3]], and [[SIRT6]], are well-known mediators of aging; however, li ...

...in-1 can induce cellular senescence in astrocytes possibly by inhibiting [[SIRT1]] and [[SIRT2]], which may play particular roles in brain aging and neurode ...ence and vascular aging, which is probably associated with repression of [[SIRT1]] expression and increased oxidative stress, and, thus, the activation of t ...

...levels) in parallel to decreased H S production and rejuvenation (LC3 and SIRT1)-related gene expression. In addition, [[CBS]] gene KD in ASC52telo cells r ...

...lleviates nonalcoholic steatohepatitis in middle-aged Apoe mice: role of [[SIRT1]]. |title=Activation of FoxO1/[[SIRT1]]/RANKL/OPG pathway may underlie the therapeutic effects of resveratrol on ...

...ibrosis by reducing renal tubular epithelial cell senescence through the [[SIRT1]]/PINK1/mitophagy axis. ...n involved inhibition of RTEC senescence, possibly through activation of [[SIRT1]]/PINK1/Parkin-mediated mitophagy. These findings suggest that pharmacologi ...

.... The three down-regulated mRNA in cellular aging, [[ELK1]], [[FOS]] and [[SIRT1]], were increased with tocotrienol-rich fraction treatment. Expression of [ ...

...s, Cyclin A2, Cyclin D1, [[CDK2]], [[CDK6]], [[ETS1]], [[NBN]], [[RB1]], [[SIRT1]], were down-regulated. The increase in cyclin-dependent kinase inhibitors ...

(Saccharomyces cerevisiae) (SIRT1) ...mating type information regulation 2 homolog 1 (Saccharomyces cerevisiae) (SIRT1), have generated significant excitement for furthering novel therapies appl ...

...d females compared to pooled males. In the kidneys, expression of Ampk and Sirt1 was also lower in female mice. In the liver, no differences between males a ...

.... The three down-regulated mRNA in cellular aging, [[ELK1]], [[FOS]] and [[SIRT1]], were increased with tocotrienol-rich fraction treatment. Expression of [ ...ranscriptional co-regulation of the [[CDKN1A]] (p21(WAF1) (/) (CIP1) ) and SIRT1 genes. ...

...alleviates nonalcoholic steatohepatitis in middle-aged Apoe mice: role of SIRT1. |title=Activation of FoxO1/SIRT1/RANKL/OPG pathway may underlie the therapeutic effects of resveratrol on ag ...

...the fibrotic lungs of aged miR-34a-/- mice. We found that miR-34a targeted Sirt1, a master anti-aging regulator, and two key cell cycle modulators, [[E2F3]] ...

...trol as an antiaging component. There are reports that it can activate the Sirt1 gene related to antiaging, emulating the effects obtained by caloric restri ...

...ed galactosidase, beta 1; SASP: senescence-associated secretory phenotype; SIRT1: sirtuin 1; Spautin 1: specific and potent autophagy inhibitor 1; [[SQSTM1] ...

...ed galactosidase, beta 1; SASP: senescence-associated secretory phenotype; SIRT1: sirtuin 1; Spautin 1: specific and potent autophagy inhibitor 1; [[SQSTM1] ...

...s, Cyclin A2, Cyclin D1, [[CDK2]], [[CDK6]], [[ETS1]], [[NBN]], [[RB1]], [[SIRT1]], were down-regulated. The increase in cyclin-dependent kinase inhibitors ...rlying mechanism remains elusive. Here, we report that Sirtinol, a known [[SIRT1]] inhibitor, induces premature senescence and growth arrest in K562 CML cel ...

...ncreased senescence which may be attributable to decreased expression of [[SIRT1]]. * sirtuin 1 (SIRT1) ...

...ng; [[AMH]] level; estrous cycle; mTOR activity; [[GDF9]], [[BMP15]], LHR, Sirt1, and Cyp19a level; ROS and annexin V level; [[IL6]] and adiponectin level; ...

...a significant difference between the [[RET]] and CTR in serum levels of [[SIRT1]] (P = 0.001), [[SIRT3]] (P = 0.001), [[SIRT6]] (P = 0.037), PGC1-α ...

...enoside Rg1 protects against Sca-1 HSC/HPC cell aging by regulating the [[SIRT1]]-[[FOXO3]] and [[SIRT3]]-[[SOD2]] signaling pathways in a γ-ray irradiati ...study indicates that Rg1 exerts anti-aging effects via the regulation of [[SIRT1]]-[[FOXO3]] and [[SIRT3]]-[[SOD2]] signaling pathways, and triggering the p ...

...des elevated [[CD38]] NADase and reduced poly(ADP-ribose) polymerase and [[SIRT1]] activities, respectively, affecting many associated biological pathways. ...ncy Alleviates D-Galactose-Induced Myocardial Cell Senescence Through NAD /Sirt1 Signaling Pathway. ...

...rlying mechanism remains elusive. Here, we report that Sirtinol, a known [[SIRT1]] inhibitor, induces premature senescence and growth arrest in K562 CML cel * SIRT1 ...

...alleviates nonalcoholic steatohepatitis in middle-aged Apoe mice: role of SIRT1. |title=Activation of FoxO1/SIRT1/RANKL/OPG pathway may underlie the therapeutic effects of resveratrol on ag ...

...the 4 potential candidate genes [[ETV1]], [[ONECUT1]], [[MACROD2]], and [[SIRT1]], which directly (via disease resistance mechanisms) or indirectly (via mi ...

...by accelerated aging-related mechanisms. Sirtuins (SIRTs), particularly [[SIRT1]], [[SIRT3]], and [[SIRT6]], are well-known mediators of aging; however, li ...

* SIRT1 ...

...cence and protected cells from H O -induced premature senescence through [[SIRT1]]. ...which suggests that the anti-senescence effect of [[FGF21]] on HUVECs is [[SIRT1]]-dependent. These results support the potential of [[FGF21]] as a therapeu ...

...abolism. EGCG significantly increased the protein expression of [[FOXO1]], Sirt1, [[CAT]], [[FABP1]], [[GSTA2]], [[ACSL1]] and [[CPT2]] but significantly de ...

...g-related processes, including dietary restriction (PPARG, [[PPARGC1A]], [[SIRT1]], [[SIRT3]], [[UCP2]], UCP3), metabolism (IGF1R, [[APOB]], SCD), autophagy ...

...enoside Rg1 protects against Sca-1 HSC/HPC cell aging by regulating the [[SIRT1]]-[[FOXO3]] and [[SIRT3]]-[[SOD2]] signaling pathways in a γ-ray irradiati |title=Redox regulation of [[SIRT1]] in inflammation and cellular senescence. ...

...alleviates nonalcoholic steatohepatitis in middle-aged Apoe mice: role of SIRT1. |title=Activation of FoxO1/SIRT1/RANKL/OPG pathway may underlie the therapeutic effects of resveratrol on ag ...

...ed galactosidase, beta 1; SASP: senescence-associated secretory phenotype; SIRT1: sirtuin 1; Spautin 1: specific and potent autophagy inhibitor 1; [[SQSTM1] ...

...ects the Myocardium from Ageing-Dependent Dysfunction: Potential Role of [[SIRT1]]. ...s) of NAR (100 mg/kg/day) to 6-month-old mice leads to an enhancement of [[SIRT1]] expression and a marked reduction of reactive oxygen species production i ...

|title=Effects of long-term resveratrol-induced [[SIRT1]] activation on insulin and apoptotic signalling in aged skeletal muscle. ...ibrosis by reducing renal tubular epithelial cell senescence through the [[SIRT1]]/PINK1/mitophagy axis. ...

...cations seem to be positively associated to longevity, including SNPs in [[SIRT1]], [[APOE]], FOXO3A, [[ACE]], [[ATM]], [[NOS1]] and [[NOS2]] gene. Epigenet |title=Overcoming [[ATM]] Deficiency by Activating the NAD /[[SIRT1]] Axis. ...

...d protein and mRNA levels of [[APOE]], [[ATG7]], [[FGF2]], [[PTEN]], and [[SIRT1]]. Adipogenic differentiation of old visceral ASCs was significantly decrea ...stpones rat bone marrow mesenchymal stem cell senescence by mediating NAD -Sirt1 signaling. ...