Aging genes 3

• Genes with 1-2 pubs
• Genes with 3 and more pubs

CD4

• Identification of Key Genes and Potential New Biomarkers for Ovarian Aging: A Study Based on RNA-Sequencing Data. / 2020 / PubMed / Full text
• Distinct Age-Related Epigenetic Signatures in CD4 and CD8 T Cells. / 2020 / PubMed / Full text
• IL-1β-MyD88-mTOR Axis Promotes Immune-Protective IL-17A Foxp3 Cells During Mucosal Infection and Is Dysregulated With Aging. / 2020 / PubMed / Full text
• Thymus involution sets the clock of declined immunity and repair with aging. / 25.11.2020 / PubMed / Full text
• Food insecurity and T-cell dysregulation in women living with HIV on antiretroviral therapy. / 28.11.2020 / PubMed / Full text
• Rapamycin Eyedrops Increased CD4 Foxp3 Cells and Prevented Goblet Cell Loss in the Aged Ocular Surface. / 24.11.2020 / PubMed / Full text
• Antioxidants N-Acetylcysteine and Vitamin C Improve T Cell Commitment to Memory and Long-Term Maintenance of Immunological Memory in Old Mice. / 19.11.2020 / PubMed / Full text
• Evolution of comorbidities in people living with HIV between 2004 and 2014: cross-sectional analyses from ANRS CO3 Aquitaine cohort. / 16.11.2020 / PubMed / Full text
• Impact of age on CD4 recovery and viral suppression over time among adults living with HIV who initiated antiretroviral therapy in the African Cohort Study. / 12.11.2020 / PubMed / Full text
• hPMSCs protects against D-galactose-induced oxidative damage of CD4 T cells through activating Akt-mediated Nrf2 antioxidant signaling. / 04.11.2020 / PubMed / Full text
• Substantial gap in primary care: older adults with HIV presenting late to care. / 31.10.2020 / PubMed / Full text
• Quantitative Digitography Measures Fine Motor Disturbances in Chronically Treated HIV Similar to Parkinson's Disease. / 2020 / PubMed / Full text
• Monocyte and T Cell Immune Phenotypic Profiles Associated With Age Advancement Differ Between People With HIV, Lifestyle-Comparable Controls and Blood Donors. / 2020 / PubMed / Full text
• HIV and three dimensions of Wisdom: Association with cognitive function and physical and mental well-being: For: Psychiatry Research. / 12.2020 / PubMed / Full text
• CD8 T cells are present at low levels in the white matter with physiological and pathological aging. / 13.10.2020 / PubMed / Full text
• Immunotherapy in older patients with cancer. / 26.07.2020 / PubMed / Full text
• Multiple genetic programs contribute to CD4 T cell memory differentiation and longevity by maintaining T cell quiescence. / 11.2020 / PubMed / Full text
• Conventional Treatment for Multiple Myeloma Drives Premature Aging Phenotypes and Metabolic Dysfunction in T Cells. / 2020 / PubMed / Full text
• Immunosenescence: the role of age in multiple sclerosis. / 19.09.2020 / PubMed / Full text
• Umbilical cord mesenchymal stem cells protect thymus structure and function in aged C57 mice by downregulating aging-related genes and upregulating autophagy- and anti-oxidative stress-related genes. / 14.09.2020 / PubMed / Full text
• Impaired Cytotoxic CD8 T Cell Response in Elderly COVID-19 Patients. / 18.09.2020 / PubMed / Full text
• What are the roles of antibodies versus a durable, high quality T-cell response in protective immunity against SARS-CoV-2? / 11.12.2020 / PubMed / Full text
• Per2 Upregulation in Circulating Hematopoietic Progenitor Cells During Chronic HIV Infection. / 2020 / PubMed / Full text
• COVID-19: age, Interleukin-6, C-reactive protein, and lymphocytes as key clues from a multicentre retrospective study. / 2020 / PubMed / Full text
• Immunosenescence profiles are not associated with muscle strength, physical performance and sarcopenia risk in very old adults: The Newcastle 85+ Study. / 09.2020 / PubMed / Full text
• Homeostasis and the functional roles of CD4 Treg cells in aging. / 10.2020 / PubMed / Full text
• A Comprehensive Evaluation of the Impact of Bovine Milk Containing Different Beta-Casein Profiles on Gut Health of Ageing Mice. / 19.07.2020 / PubMed / Full text
• Premature aging of circulating T cells predicts all-cause mortality in hemodialysis patients. / 13.07.2020 / PubMed / Full text
• In-depth immune cellular profiling reveals sex-specific associations with frailty. / 2020 / PubMed / Full text
• CD70 contributes to age-associated T cell defects and overwhelming inflammatory responses. / 19.06.2020 / PubMed / Full text
• Comparison of Overall and Comorbidity-Free Life Expectancy Between Insured Adults With and Without HIV Infection, 2000-2016. / 01.06.2020 / PubMed / Full text
• Comparative Analysis of Age-Related Changes in Lacrimal Glands and Meibomian Glands of a C57BL/6 Male Mouse Model. / 11.06.2020 / PubMed / Full text
• Thymus aging in mice deficient in either EphB2 or EphB3, two master regulators of thymic epithelium development. / 10.2020 / PubMed / Full text
• CD8 T-cell senescence and skewed lymphocyte subsets in young Dyskeratosis Congenita patients with PARN and DKC1 mutations. / 09.2020 / PubMed / Full text
• Short-Term Environmental Enrichment is a Stronger Modulator of Brain Glial Cells and Cervical Lymph Node T Cell Subtypes than Exercise or Combined Exercise and Enrichment. / 25.05.2020 / PubMed / Full text
• Viral and host factors related to the clinical outcome of COVID-19. / 07.2020 / PubMed / Full text
• Use of comedications and potential drug-drug interactions in people living with HIV in China. / 07.2020 / PubMed / Full text
• CD4 T helper 17 cell response of aged mice promotes prostate cancer cell migration and invasion. / 07.2020 / PubMed / Full text
• The Rules of Human T Cell Fate [i]in vivo[/i]. / 2020 / PubMed / Full text
• CD4/CD8 ratio, comorbidities, and aging in treated HIV infected individuals on viral suppression. / 21.04.2020 / PubMed / Full text
• The effects of advanced maternal age on T-cell subsets at the maternal-fetal interface prior to term labor and in the offspring: a mouse study. / 07.2020 / PubMed / Full text
• Structural and Functional Changes in the Mesenteric Lymph Nodes in Humans during Aging. / 03.2020 / PubMed / Full text
• Neurocognitive Functioning is Associated with Self-Reported and Performance-Based Treatment Management Abilities in People Living with HIV with Low Health Literacy. / 24.07.2020 / PubMed / Full text
• Blockade of Stat3 oncogene addiction induces cellular senescence and reveals a cell-nonautonomous activity suitable for cancer immunotherapy. / 2020 / PubMed / Full text
• Age-related changes in T lymphocytes of patients with head and neck squamous cell carcinoma. / 2020 / PubMed / Full text
• Immunological history governs human stem cell memory CD4 heterogeneity via the Wnt signaling pathway. / 10.02.2020 / PubMed / Full text
• Estimating HIV Management and Comorbidity Costs Among Aging HIV Patients in the United States: A Systematic Review. / 02.2020 / PubMed / Full text
• Sex Differences in People Aging With HIV. / 01.03.2020 / PubMed / Full text
• Identification of Differentially Expressed miRNAs in the Response of Spleen CD4 T Cells to Electroacupuncture in Senescence-Accelerated Mice. / 03.2020 / PubMed / Full text
• Thymus Involution and Intravenous Drug Abuse. / 03.2020 / PubMed / Full text
• Depletion of CD4 T cells provides therapeutic benefits in aged mice after ischemic stroke. / 04.2020 / PubMed / Full text
• Immunological and Virological Responses in Older HIV-Infected Adults Receiving Antiretroviral Therapy: An Evidence-Based Meta-Analysis. / 01.04.2020 / PubMed / Full text
• African Mitochondrial DNA Haplogroup L2 Is Associated With Slower Decline of β-cell Function and Lower Incidence of Diabetes Mellitus in Non-Hispanic, Black Women Living With Human Immunodeficiency Virus. / 05.11.2020 / PubMed / Full text
• DP1 Activation Reverses Age-Related Hypertension Via NEDD4L-Mediated T-Bet Degradation in T Cells. / 25.02.2020 / PubMed / Full text
• An Emerging Concern-High Rates of Frailty among Middle-aged and Older Individuals Living with HIV. / 12.2019 / PubMed / Full text
• Higher Acuity Resource Utilization With Older Age and Poorer HIV Control in Adolescents and Young Adults in the HIV Research Network. / 01.04.2020 / PubMed / Full text
• Mitochondrial DNA Haplogroups and Frailty in Adults Living with HIV. / 03.2020 / PubMed / Full text
• Gallic acid attenuates thymic involution in the d-galactose induced accelerated aging mice. / 01.2020 / PubMed / Full text
• Mitochondrial mass governs the extent of human T cell senescence. / 02.2020 / PubMed / Full text
• T cells and immune functions of plasma extracellular vesicles are differentially modulated from adults to centenarians. / 27.11.2019 / PubMed / Full text
• Defects in Antiviral T Cell Responses Inflicted by Aging-Associated miR-181a Deficiency. / 19.11.2019 / PubMed / Full text
• Increased Prevalence of Neurocognitive Impairment in Aging People Living With Human Immunodeficiency Virus: The ANRS EP58 HAND 55-70 Study. / 10.06.2020 / PubMed / Full text
• Age-associated changes in human CD4 T cells point to mitochondrial dysfunction consequent to impaired autophagy. / 09.11.2019 / PubMed / Full text
• Sex Differences in the Blood Transcriptome Identify Robust Changes in Immune Cell Proportions with Aging and Influenza Infection. / 12.11.2019 / PubMed / Full text
• Going Beyond Giving Antiretroviral Therapy: Multimorbidity in Older People Aging with HIV in Nigeria. / 03.2020 / PubMed / Full text
• Alterations in composition of immune cells and impairment of anti-tumor immune response in aged oral cancer-bearing mice. / 12.2019 / PubMed / Full text
• LTA1 is a safe, intranasal enterotoxin-based adjuvant that improves vaccine protection against influenza in young, old and B-cell-depleted (μMT) mice. / 22.10.2019 / PubMed / Full text
• Thymus Imaging Detection and Size Is Inversely Associated With Metabolic Syndrome and Frailty in People With HIV. / 10.2019 / PubMed / Full text
• Alterations in peripheral T cell and B cell subsets in patients with osteoarthritis. / 02.2020 / PubMed / Full text
• Short Communication: Carotid Intima-Media Thickness Is Not Associated with Neurocognitive Impairment Among People Older than 50 Years With and Without HIV Infection from Thailand. / 11-12.2019 / PubMed / Full text
• Implications of Immune Checkpoint Expression During Aging in HIV-Infected People on Antiretroviral Therapy. / 11-12.2019 / PubMed / Full text
• Age-related alterations in human gut CD4 T cell phenotype, T helper cell frequencies, and functional responses to enteric bacteria. / 01.2020 / PubMed / Full text
• Determinants of blood telomere length in antiretroviral treatment-naïve HIV-positive participants enrolled in the NEAT 001/ANRS 143 clinical trial. / 11.2019 / PubMed / Full text
• Human T Cell Differentiation Negatively Regulates Telomerase Expression Resulting in Reduced Activation-Induced Proliferation and Survival. / 2019 / PubMed / Full text
• Short Communication: Getting Older with HIV: Increasing Frequency of Comorbidities and Polypharmacy in Brazilian HIV Patients. / 11-12.2019 / PubMed / Full text
• Gait Speed Decline Is Associated with Hemoglobin A1C, Neurocognitive Impairment, and Black Race in Persons with HIV. / 11-12.2019 / PubMed / Full text
• Noncommunicable Diseases Burden and Risk Factors in a Cohort of HIV+ Elderly Patients in Malawi. / 11-12.2019 / PubMed / Full text
• Aging promotes reorganization of the CD4 T cell landscape toward extreme regulatory and effector phenotypes. / 08.2019 / PubMed / Full text
• Prevalence of hypertension and cardiovascular risk factors among long-term AIDS survivors: A report from the field. / 10.2019 / PubMed / Full text

TNF

• Naringenin alleviates nonalcoholic steatohepatitis in middle-aged Apoe mice: role of SIRT1. / 18.11.2020 / PubMed / Full text
• Protective role of microglial HO-1 blockade in aging: Implication of iron metabolism. / 06.11.2020 / PubMed / Full text
• Anti-aging effect of DL-β-hydroxybutyrate against hepatic cellular senescence induced by D-galactose or γ-irradiation via autophagic flux stimulation in male rats. / 01-02.2021 / PubMed / Full text
• Exploring the extensive crosstalk between the antagonistic cytokines- TGF-β and TNF-α in regulating cancer pathogenesis. / 03.11.2020 / PubMed / Full text
• Long non-coding RNA SNHG29 regulates cell senescence via p53/p21 signaling in spontaneous preterm birth. / 15.10.2020 / PubMed / Full text
• Cognition Is Associated With Peripheral Immune Molecules in Healthy Older Adults: A Cross-Sectional Study. / 2020 / PubMed / Full text
• Anti-aging effects of [i]Ribes meyeri[/i] anthocyanins on neural stem cells and aging mice. / 12.09.2020 / PubMed / Full text
• Effects of a four week detraining period on physical, metabolic, and inflammatory profiles of elderly women who regularly participate in a program of strength training. / 2020 / PubMed / Full text
• Contribution of Porphyromonas gingivalis lipopolysaccharide to experimental periodontitis in relation to aging. / 26.08.2020 / PubMed / Full text
• New MoDC-Targeting TNF Fusion Proteins Enhance Cyclic Di-GMP Vaccine Adjuvanticity in Middle-Aged and Aged Mice. / 2020 / PubMed / Full text
• Cognitive impairment in elderly patients with rheumatic disease and the effect of disease-modifying anti-rheumatic drugs. / 30.08.2020 / PubMed / Full text
• Cotinine ameliorates memory and learning impairment in senescent mice. / 11.2020 / PubMed / Full text
• Kynurenines link chronic inflammation to functional decline and physical frailty. / 20.08.2020 / PubMed / Full text
• Voluntary exercise training attenuated the middle-aged maturity-induced cardiac apoptosis. / 15.10.2020 / PubMed / Full text
• Preclinical Evaluation of a Food-Derived Functional Ingredient to Address Skeletal Muscle Atrophy. / 29.07.2020 / PubMed / Full text
• Childhood survivors of high-risk neuroblastoma show signs of immune recovery and not immunosenescence. / 12.2020 / PubMed / Full text
• FK506 induces lung lymphatic endothelial cell senescence and downregulates LYVE-1 expression, with associated decreased hyaluronan uptake. / 31.07.2020 / PubMed / Full text
• Late-onset hypogonadism: Reductio ad absurdum of the cardiovascular risk-benefit of testosterone replacement therapy. / 11.2020 / PubMed / Full text
• Doxorubicin generates senescent microglia that exhibit altered proteomes, higher levels of cytokine secretion, and a decreased ability to internalize amyloid β. / 15.10.2020 / PubMed / Full text
• Time restricted feeding provides a viable alternative to alternate day fasting when evaluated in terms of redox homeostasis in rats. / 16.07.2020 / PubMed / Full text
• Associations Between Plasma Immunomodulatory and Inflammatory Mediators With VACS Index Scores Among Older HIV-Infected Adults on Antiretroviral Therapy. / 2020 / PubMed / Full text
• Chrysin Impact on Oxidative and Inflammation Damages in the Liver of Aged Male Rats. / 17.07.2020 / PubMed / Full text
• Correction of immunosuppression in aged septic rats by human ghrelin and growth hormone through the vagus nerve-dependent inhibition of TGF-β production. / 16.07.2020 / PubMed / Full text
• Epigenetics of neuroinflammation: Immune response, inflammatory response and cholinergic synaptic involvement evidenced by genome-wide DNA methylation analysis of delirious inpatients. / 10.2020 / PubMed / Full text
• [i]Andrographis paniculata[/i] and Its Bioactive Diterpenoids Against Inflammation and Oxidative Stress in Keratinocytes. / 17.06.2020 / PubMed / Full text
• Etanercept improves aging-induced cognitive deficits by reducing inflammation and vascular dysfunction in rats. / 01.10.2020 / PubMed / Full text
• Bacterial antigen translocation and age as BMI-independent contributing factors on systemic inflammation in NAFLD patients. / 09.2020 / PubMed / Full text
• Bone marrow mesenchymal stem cells improve thymus and spleen function of aging rats through affecting P21/PCNA and suppressing oxidative stress. / 19.06.2020 / PubMed / Full text
• Glycolic acid adjusted to pH 4 stimulates collagen production and epidermal renewal without affecting levels of proinflammatory TNF-alpha in human skin explants. / 24.06.2020 / PubMed / Full text
• A20 of nucleus pulposus cells plays a self-protection role via the nuclear factor-kappa B pathway in the inflammatory microenvironment. / 05.2020 / PubMed / Full text
• Age-associated decline in neural, endocrine, and immune responses in men and women: Involvement of intracellular signaling pathways. / 15.08.2020 / PubMed / Full text
• Classical and lectin complement pathways and markers of inflammation for investigation of susceptibility to infections among healthy older adults. / 2020 / PubMed / Full text
• Activation of FoxO1/SIRT1/RANKL/OPG pathway may underlie the therapeutic effects of resveratrol on aging-dependent male osteoporosis. / 12.06.2020 / PubMed / Full text
• The senescence-associated secretome as an indicator of age and medical risk. / 18.06.2020 / PubMed / Full text
• Exercise Partially Rejuvenates Muscle Stem Cells. / 06.2020 / PubMed / Full text
• Brazilian berry extract (Myrciaria jaboticaba): A promising therapy to minimize prostatic inflammation and oxidative stress. / 08.2020 / PubMed / Full text
• Potential therapeutic effects of endothelial cells trans-differentiated from Wharton's Jelly-derived mesenchymal stem cells on altered vascular functions in aged diabetic rat model. / 2020 / PubMed / Full text
• [Effect of fragmented sleep on postoperative cognitive function and central neuroinflammation]. / 05.05.2020 / PubMed / Full text
• Can blocking inflammation enhance immunity during aging? / 05.2020 / PubMed / Full text
• [FAS- and TNF-dependent ways participation in apoptosis mechanisms in hypotalumus in physiological and pathological aging.] / 2020 / PubMed
• Ultrasound-guided continuous thoracic paravertebral block alleviates postoperative delirium in elderly patients undergoing esophagectomy: A randomized controlled trial. / 04.2020 / PubMed / Full text
• 17β-Estradiol improves insulin signalling and insulin resistance in the aged female hearts: Role of inflammatory and anti-inflammatory cytokines. / 15.07.2020 / PubMed / Full text
• Synergistic Antitumor Efficacy of Magnetohyperthermia and Poly(lactic-co-glycolic acid)-Encapsulated Selol in Ehrlich Breast Adenocarcinoma Treatment in Elderly Swiss Mice. / 01.02.2020 / PubMed / Full text
• Pinitol suppresses TNF-α-induced chondrocyte senescence. / 19.03.2020 / PubMed / Full text
• [Aging of skin fibroblasts: genetic and epigenetic factors.] / 2019 / PubMed
• Functional and traditional training improve muscle power and reduce proinflammatory cytokines in older women: A randomized controlled trial. / 01.07.2020 / PubMed / Full text
• Associations of TNF-α -308 G>A and TNF-β 252 A>G with Physical Function and BNP-Rugao Longevity and Ageing Study. / 2020 / PubMed / Full text
• 3D TECA hydrogel reduces cellular senescence and enhances fibroblasts migration in wound healing. / 07.2018 / PubMed / Full text
• Regulatory Effect of Anwulignan on the Immune Function Through Its Antioxidation and Anti-Apoptosis in D-Galactose-Induced Aging Mice. / 2020 / PubMed / Full text
• Pretreatment Frailty Is Independently Associated With Increased Risk of Infections After Immunosuppression in Patients With Inflammatory Bowel Diseases. / 06.2020 / PubMed / Full text
• The Citrus Flavonoid Naringenin Protects the Myocardium from Ageing-Dependent Dysfunction: Potential Role of SIRT1. / 2020 / PubMed / Full text
• In the Absence of a TCR Signal IL-2/IL-12/18-Stimulated γδ T Cells Demonstrate Potent Anti-Tumoral Function Through Direct Killing and Senescence Induction in Cancer Cells. / 04.01.2020 / PubMed / Full text
• Aging is associated with loss of beneficial effects of estrogen on leptin responsiveness in mice fed high fat diet: Role of estrogen receptor α and cytokines. / 03.2020 / PubMed / Full text
• Mitochondrial Dysfunction and Alpha-Lipoic Acid: Beneficial or Harmful in Alzheimer's Disease? / 2019 / PubMed / Full text
• Design, synthesis and evaluation of diosgenin carbamate derivatives as multitarget anti-Alzheimer's disease agents. / 01.02.2020 / PubMed / Full text
• Oral Administration of Okara Soybean By-Product Attenuates Cognitive Impairment in a Mouse Model of Accelerated Aging. / 03.12.2019 / PubMed / Full text
• Electric vagal nerve stimulation inhibits inflammation and improves early postoperation cognitive dysfunction in aged rats. / 23.11.2019 / PubMed / Full text
• Metformin decreases LPS-induced inflammatory response in rabbit annulus fibrosus stem/progenitor cells by blocking HMGB1 release. / 26.11.2019 / PubMed / Full text
• The effects of blueberry and strawberry serum metabolites on age-related oxidative and inflammatory signaling in vitro. / 11.12.2019 / PubMed / Full text
• Arsenic induces human chondrocyte senescence and accelerates rat articular cartilage aging. / 01.2020 / PubMed / Full text
• Bone Benefits of Fish Oil Supplementation Depend on its EPA and DHA Content. / 08.11.2019 / PubMed / Full text
• Inflammaging phenotype in rhesus macaques is associated with a decline in epithelial barrier-protective functions and increased pro-inflammatory function in CD161-expressing cells. / 12.2019 / PubMed / Full text
• Single-cell transcriptomics reveals expansion of cytotoxic CD4 T cells in supercentenarians. / 26.11.2019 / PubMed / Full text
• Gut microbiota combined with metabolomics reveals the metabolic profile of the normal aging process and the anti-aging effect of FuFang Zhenshu TiaoZhi(FTZ) in mice. / 01.2020 / PubMed / Full text
• Intervertebral disc ageing and degeneration: The antiapoptotic effect of oestrogen. / 01.2020 / PubMed / Full text
• MicroRNA 16-5p is upregulated in calorie-restricted mice and modulates inflammatory cytokines of macrophages. / 30.01.2020 / PubMed / Full text
• Aerobic exercise modulates cytokine profile and sleep quality in elderly. / 06.2019 / PubMed / Full text
• Trehalose targets Nrf2 signal to alleviate d-galactose induced aging and improve behavioral ability. / 01.01.2020 / PubMed / Full text
• Anti-Inflammatory and Anti-Aging Evaluation of Pigment-Protein Complex Extracted from [i]Chlorella Pyrenoidosa[/i]. / 16.10.2019 / PubMed / Full text
• Inflammatory mediators and the risk of falls among older women with acute low back pain: data from Back Complaints in the Elders (BACE)-Brazil. / 03.2020 / PubMed / Full text
• Acetylcholinesterase inhibitors targeting the cholinergic anti-inflammatory pathway: a new therapeutic perspective in aging-related disorders. / 03.10.2019 / PubMed / Full text
• Study on Metabolic Trajectory of Liver Aging and the Effect of Fufang Zhenzhu Tiaozhi on Aging Mice. / 2019 / PubMed / Full text
• Systemic Tumor Necrosis Factor-Alpha Trajectories Relate to Brain Health in Typically Aging Older Adults. / 13.07.2020 / PubMed / Full text
• Targeting senescence improves angiogenic potential of adipose-derived mesenchymal stem cells in patients with preeclampsia. / 14.09.2019 / PubMed / Full text
• Suppression of gut dysbiosis by Bifidobacterium longum alleviates cognitive decline in 5XFAD transgenic and aged mice. / 14.08.2019 / PubMed / Full text
• Moderate hyperoxia induces senescence in developing human lung fibroblasts. / 01.11.2019 / PubMed / Full text
• Aging-related carcinoembryonic antigen-related cell adhesion molecule 1 signaling promotes vascular dysfunction. / 12.2019 / PubMed / Full text
• Microglia Express Insulin-Like Growth Factor-1 in the Hippocampus of Aged APP /PS1 Transgenic Mice. / 2019 / PubMed / Full text
• Age- and diet-specific effects of chronic exposure to chlorpyrifos on hormones, inflammation and gut microbiota in rats. / 09.2019 / PubMed / Full text

HR

• Patients with hip fracture and total hip arthroplasty surgery differ in anthropometric, but not cardiovascular screening abnormalities. / 02.12.2020 / PubMed / Full text
• Clinical Role of Lung Ultrasound for the Diagnosis and Prognosis of Coronavirus Disease Pneumonia in Elderly Patients: A Pivotal Study. / 03.12.2020 / PubMed / Full text
• The Relationship of Accelerometer-Assessed Standing Time With and Without Ambulation and Mortality: The WHI OPACH Study. / 12.10.2020 / PubMed / Full text
• Age-related myofiber atrophy in old mice is reversed by ten weeks voluntary high-resistance wheel running. / 09.11.2020 / PubMed / Full text
• Predicted Skeletal Muscle Mass and 4-Year Cardiovascular Disease Incidence in Middle-Aged and Elderly Participants of IKARIA Prospective Epidemiological Study: The Mediating Effect of Sex and Cardiometabolic Factors. / 27.10.2020 / PubMed / Full text
• Obesity is associated with early hip fracture risk in postmenopausal women: a 25-year follow-up. / 23.10.2020 / PubMed / Full text
• ATM inhibition synergizes with fenofibrate in high grade serous ovarian cancer cells. / 09.2020 / PubMed / Full text
• Effectiveness of adjuvant FOLFOX vs 5FU/LV in adults over age 65 with stage II and III colon cancer using a novel hybrid approach. / 12.2020 / PubMed / Full text
• Age, Frailty, and Comorbidity as Prognostic Factors for Short-Term Outcomes in Patients With Coronavirus Disease 2019 in Geriatric Care. / 11.2020 / PubMed / Full text
• Clinical and demographic parameters predict the progression from mild cognitive impairment to dementia in elderly patients. / 12.09.2020 / PubMed / Full text
• Plasma Dehydroepiandrosterone Sulfate and Cardiovascular Disease Risk in Older Men and Women. / 01.12.2020 / PubMed / Full text
• High intensity interval training combined with L-citrulline supplementation: Effects on physical performance in healthy older adults. / 15.10.2020 / PubMed / Full text
• Associations of blood pressure with risk of injurious falls in old age vary by functional status: A cohort study. / 15.10.2020 / PubMed / Full text
• Epigenetic age acceleration and clinical outcomes in gliomas. / 2020 / PubMed / Full text
• Do Stairs Inhibit Seniors Who Live on Upper Floors From Going Out? / 10.2020 / PubMed / Full text
• Age-specific acute changes in carotid-femoral pulse wave velocity with head-up tilt. / 07.07.2020 / PubMed / Full text
• Pre-frailty status increases the risk of rehospitalization in patients after elective cardiac surgery without complication. / 06.2020 / PubMed / Full text
• Comparative Performance of Creatinine-Based GFR Estimation Equations in Exceptional Longevity: The Rugao Longevity and Ageing Study. / 2020 / PubMed / Full text
• Sex-and race-specific associations of protein intake with change in muscle mass and physical function in older adults: the Health, Aging, and Body Composition (Health ABC) Study. / 01.07.2020 / PubMed / Full text
• Deterioration of bone microstructure by aging and menopause in Japanese healthy women: analysis by HR-pQCT. / 11.2020 / PubMed / Full text
• Association between Low Protein Intake and Mortality in Patients with Type 2 Diabetes. / 01.06.2020 / PubMed / Full text
• CAUSES, mortality rates and risk factors of death in community-dwelling Europeans aged 50 years and over: Results from the Survey of Health, Ageing and Retirement in Europe 2013-2015. / 07-08.2020 / PubMed / Full text
• Estimation of Wave Condition Number From Pressure Waveform Alone and Its Changes With Advancing Age in Healthy Women and Men. / 2020 / PubMed / Full text
• Extended in vitro culture of primary human mesenchymal stem cells downregulates Brca1-related genes and impairs DNA double-strand break recognition. / 07.2020 / PubMed / Full text
• Effect of artificial dawn light on cardiovascular function, alertness, and balance in middle-aged and older adults. / 13.10.2020 / PubMed / Full text
• Heart Rate Performance Curve Is Dependent on Age, Sex, and Performance. / 2020 / PubMed / Full text
• Physical activity trajectories, mortality, hospitalization, and disability in the Toledo Study of Healthy Aging. / 08.2020 / PubMed / Full text
• U-Shaped Association of Plasma Testosterone, and no Association of Plasma Estradiol, with Incidence of Fractures in Men. / 01.05.2020 / PubMed / Full text
• Pregnancy-Related Bone Mineral and Microarchitecture Changes in Women Aged 30 to 45 Years. / 07.2020 / PubMed / Full text
• Analysis of the world record time for combined father and son marathon. / 01.02.2020 / PubMed / Full text
• Age-related reductions in heart rate variability do not worsen during exposure to humid compared to dry heat: A secondary analysis. / 2019 / PubMed / Full text
• Efficacy and Safety of Dapagliflozin in the Elderly: Analysis From the DECLARE-TIMI 58 Study. / 02.2020 / PubMed / Full text
• Validity of Prediction Equations of Maximal Heart Rate in Physically Active Female Adolescents and the Role of Maturation. / 13.11.2019 / PubMed / Full text
• Base excision repair but not DNA double-strand break repair is impaired in aged human adipose-derived stem cells. / 02.2020 / PubMed / Full text
• Urban-Rural Differences in Hip Fracture Mortality: A Nationwide NOREPOS Study. / 11.2019 / PubMed / Full text
• Malnutrition as a Strong Predictor of the Onset of Sarcopenia. / 27.11.2019 / PubMed / Full text
• Acclimation to a thermoneutral environment abolishes age-associated alterations in heart rate and heart rate variability in conscious, unrestrained mice. / 02.2020 / PubMed / Full text
• Long-term dementia risk prediction by the LIBRA score: A 30-year follow-up of the CAIDE study. / 02.2020 / PubMed / Full text
• Kidney function and its association to imminent, short- and long-term fracture risk-a longitudinal study in older women. / 01.2020 / PubMed / Full text
• Oxidatively Damaged DNA/RNA and 8-Isoprostane Levels Are Associated With the Development of Type 2 Diabetes at Older Age: Results From a Large Cohort Study. / 01.2020 / PubMed / Full text
• Associations of vigorous physical activity with all-cause, cardiovascular and cancer mortality among 64 913 adults. / 2019 / PubMed / Full text
• Reduced cerebrovascular and cardioventilatory responses to intermittent hypoxia in elderly. / 01.2020 / PubMed / Full text
• Vestibulo-sympathetic reflex in patients with bilateral vestibular loss. / 01.11.2019 / PubMed / Full text
• Heart rate and blood pressure in male Ts65Dn mice: a model to investigate cardiovascular responses in Down syndrome. / 09.2019 / PubMed / Full text
• Body weight at 10 years of age and change in body composition between 8 and 10 years of age were related to survival in a longitudinal study of 39 Labrador retriever dogs. / 09.09.2019 / PubMed / Full text
• Dietary diversity offsets the adverse mortality risk among older indigenous Taiwanese. / 2019 / PubMed / Full text
• Independent and joint effects of vascular and cardiometabolic risk factor pairs for risk of all-cause dementia: a prospective population-based study. / 10.2019 / PubMed / Full text
• Work Ability and Job Survival: Four-Year Follow-Up. / 28.08.2019 / PubMed / Full text
• Predictivity of bioimpedance phase angle for incident disability in older adults. / 02.2020 / PubMed / Full text

APOE

• Polygenic risk score of longevity predicts longer survival across an age-continuum. / 20.11.2020 / PubMed / Full text
• Association Between APOE Alleles and Change of Neuropsychological Tests in the Long Life Family Study. / 17.11.2020 / PubMed / Full text
• The APOE gene cluster responds to air pollution factors in mice with coordinated expression of genes that differs by age in humans. / 20.11.2020 / PubMed / Full text
• Homozygosity in the [i]APOE[/i] 3 Polymorphism Is Associated With Less Depression and Higher Serum Low-Density Lipoprotein in Chinese Elderly Schizophrenics. / 2020 / PubMed / Full text
• Effect of apolipoprotein E polymorphism on cognition and brain in the Cambridge Centre for Ageing and Neuroscience cohort. / 01-12.2020 / PubMed / Full text
• Cardiovascular risk factors and APOE-ε4 status affect memory functioning in aging via changes to temporal stem diffusion. / 18.10.2020 / PubMed / Full text
• APOE [i]ε[/i]4 and resting-state functional connectivity in racially/ethnically diverse older adults. / 2020 / PubMed / Full text
• Predictors of Olfactory Decline in Aging: A Longitudinal Population-Based Study. / 13.11.2020 / PubMed / Full text
• When Culture Influences Genes: Positive Age Beliefs Amplify the Cognitive-Aging Benefit of APOE ε2. / 14.09.2020 / PubMed / Full text
• Age and the association between apolipoprotein E genotype and Alzheimer disease: A cerebrospinal fluid biomarker-based case-control study. / 08.2020 / PubMed / Full text
• Estimating the potential for dementia prevention through modifiable risk factors elimination in the real-world setting: a population-based study. / 07.08.2020 / PubMed / Full text
• Machine learning-based estimation of cognitive performance using regional brain MRI markers: the Northern Manhattan Study. / 01.08.2020 / PubMed / Full text
• Effects of an APOE Promoter Polymorphism on Fronto-Parietal Functional Connectivity During Nondemented Aging. / 2020 / PubMed / Full text
• The relationship of parental longevity with the aging brain-results from UK Biobank. / 10.2020 / PubMed / Full text
• Alzheimer's Patient Microglia Exhibit Enhanced Aging and Unique Transcriptional Activation. / 30.06.2020 / PubMed / Full text
• Relationships Between Plasma Lipids Species, Gender, Risk Factors, and Alzheimer's Disease. / 2020 / PubMed / Full text
• Effects of sex, age, and apolipoprotein E genotype on hippocampal parenchymal fraction in cognitively normal older adults. / 30.07.2020 / PubMed / Full text
• Cognitive Health of Nonagenarians in Southern Italy: A Descriptive Analysis from a Cross-Sectional, Home-Based Pilot Study of Exceptional Longevity (Cilento Initiative on Aging Outcomes Or CIAO). / 05.05.2020 / PubMed / Full text
• Apolipoprotein E and Health in Older Men: The Concord Health and Ageing in Men Project. / 25.09.2020 / PubMed / Full text
• CSF amyloid is a consistent predictor of white matter hyperintensities across the disease course from aging to Alzheimer's disease. / 07.2020 / PubMed / Full text
• Association of Cardiovascular Risk Factors with Cerebral Perfusion in Whites and African Americans. / 2020 / PubMed / Full text
• Alzheimer's Risk Factors Age, APOE Genotype, and Sex Drive Distinct Molecular Pathways. / 03.06.2020 / PubMed / Full text
• Less agreeable, better preserved? A PET amyloid and MRI study in a community-based cohort. / 05.2020 / PubMed / Full text
• Physical Activity as Moderator of the Association Between APOE and Cognitive Decline in Older Adults: Results from Three Longitudinal Cohort Studies. / 25.09.2020 / PubMed / Full text
• Longitudinal Maintenance of Cognitive Health in Centenarians in the 100-plus Study. / 05.02.2020 / PubMed / Full text
• Interaction of APOE, cerebral blood flow, and cortical thickness in the entorhinal cortex predicts memory decline. / 04.2020 / PubMed / Full text
• Determinants of mesial temporal lobe volume loss in older individuals with preserved cognition: a longitudinal PET amyloid study. / 03.2020 / PubMed / Full text
• Long-term exposure to ambient air pollution, APOE-ε4 status, and cognitive decline in a cohort of older adults in northern Manhattan. / 03.2020 / PubMed / Full text
• Evidence in support of chromosomal sex influencing plasma based metabolome vs APOE genotype influencing brain metabolome profile in humanized APOE male and female mice. / 2020 / PubMed / Full text
• APOE region molecular signatures of Alzheimer's disease across races/ethnicities. / 03.2020 / PubMed / Full text
• Varying Effects of APOE Alleles on Extreme Longevity in European Ethnicities. / 13.11.2019 / PubMed / Full text
• Prospective Evaluation of Cognitive Health and Related Factors in Elderly at Risk for Developing Alzheimer's Dementia: A Longitudinal Cohort Study. / 2019 / PubMed / Full text
• Association of Cardiovascular and Alzheimer's Disease Risk Factors with Intracranial Arterial Blood Flow in Whites and African Americans. / 2019 / PubMed / Full text
• Is Ongoing Anticholinergic Burden Associated With Greater Cognitive Decline and Dementia Severity in Mild to Moderate Alzheimer's Disease? / 17.04.2020 / PubMed / Full text
• Multicenter Alzheimer's and Parkinson's disease immune biomarker verification study. / 02.2020 / PubMed / Full text
• Prospective Memory: Age related change is influenced by APOE genotype. / 09.2020 / PubMed / Full text
• Education Moderates the Relation Between APOE ɛ4 and Memory in Nondemented Non-Hispanic Black Older Adults. / 2019 / PubMed / Full text
• Apolipoprotein E ε4 allele effects on longitudinal cognitive trajectories are sex and age dependent. / 12.2019 / PubMed / Full text
• Interactive effect of age and APOE-ε4 allele load on white matter myelin content in cognitively normal middle-aged subjects. / 2019 / PubMed / Full text
• APOE modifies the interaction of entorhinal cerebral blood flow and cortical thickness on memory function in cognitively normal older adults. / 15.11.2019 / PubMed / Full text
• When time's arrow doesn't bend: APOE-ε4 influences episodic memory before old age. / 10.2019 / PubMed / Full text
• Cognitive-Motor Integration Performance Is Affected by Sex, APOE Status, and Family History of Dementia. / 2019 / PubMed / Full text
• Associations among amyloid status, age, and longitudinal regional brain atrophy in cognitively unimpaired older adults. / 10.2019 / PubMed / Full text
• Cognitive function and neuropathological outcomes: a forward-looking approach. / 12.2019 / PubMed / Full text
• APOE gene-dependent BOLD responses to a breath-hold across the adult lifespan. / 2019 / PubMed / Full text

MSC

• Rejuvenation of Senescent Endothelial Progenitor Cells by Extracellular Vesicles Derived From Mesenchymal Stromal Cells. / 11.2020 / PubMed / Full text
• Extracellular vesicles derived from bone marrow mesenchymal stem cells enhance myelin maintenance after cortical injury in aged rhesus monkeys. / 29.11.2020 / PubMed / Full text
• TPP1 Enhances the Therapeutic Effects of Transplanted Aged Mesenchymal Stem Cells in Infarcted Hearts via the MRE11/AKT Pathway. / 2020 / PubMed / Full text
• Aging-Affected MSC Functions and Severity of Periodontal Tissue Destruction in a Ligature-Induced Mouse Periodontitis Model. / 30.10.2020 / PubMed / Full text
• Human placenta-derived mesenchymal stem cells stimulate ovarian function via miR-145 and bone morphogenetic protein signaling in aged rats. / 05.11.2020 / PubMed / Full text
• Mesenchymal Stromal Cells as Critical Contributors to Tissue Regeneration. / 2020 / PubMed / Full text
• The biology of human hair greying. / 23.09.2020 / PubMed / Full text
• [i]Tsc1[/i] Regulates the Proliferation Capacity of Bone-Marrow Derived Mesenchymal Stem Cells. / 10.09.2020 / PubMed / Full text
• The role of mitochondrial dysfunction in mesenchymal stem cell senescence. / 12.2020 / PubMed / Full text
• Metabolic syndrome increases senescence-associated micro-RNAs in extracellular vesicles derived from swine and human mesenchymal stem/stromal cells. / 12.08.2020 / PubMed / Full text
• Functional heterogeneity of mesenchymal stem cells from natural niches to culture conditions: implications for further clinical uses. / 22.07.2020 / PubMed / Full text
• Functional crosstalk between mTORC1/p70S6K pathway and heterochromatin organization in stress-induced senescence of MSCs. / 13.07.2020 / PubMed / Full text
• Increased cellular senescence in the murine and human stenotic kidney: Effect of mesenchymal stem cells. / 02.2021 / PubMed / Full text
• Intrinsic Type 1 Interferon (IFN1) Profile of Uncultured Human Bone Marrow CD45 CD271 Multipotential Stromal Cells (BM-MSCs): The Impact of Donor Age, Culture Expansion and IFNα and IFNβ Stimulation. / 15.07.2020 / PubMed / Full text
• Facial rejuvenation using stem cell conditioned media combined with skin needling: A split-face comparative study. / 09.2020 / PubMed / Full text
• Mesenchymal Stem Cell Senescence and Rejuvenation: Current Status and Challenges. / 2020 / PubMed / Full text
• The changing epigenetic landscape of Mesenchymal Stem/Stromal Cells during aging. / 08.2020 / PubMed / Full text
• Dual Role of Autophagy in Regulation of Mesenchymal Stem Cell Senescence. / 2020 / PubMed / Full text
• Molecular Aspects of Adipose-Derived Stromal Cell Senescence in a Long-Term Culture: A Potential Role of Inflammatory Pathways. / 01-12.2020 / PubMed / Full text
• Human Obesity Induces Dysfunction and Early Senescence in Adipose Tissue-Derived Mesenchymal Stromal/Stem Cells. / 2020 / PubMed / Full text
• miR-155-5p inhibition rejuvenates aged mesenchymal stem cells and enhances cardioprotection following infarction. / 04.2020 / PubMed / Full text
• Mesenchymal Stem Cell Derived Extracellular Vesicles in Aging. / 2020 / PubMed / Full text
• Molecular Mechanisms Contributing to Mesenchymal Stromal Cell Aging. / 21.02.2020 / PubMed / Full text
• Inhibition of DNA Methyltransferase by RG108 Promotes Pluripotency-Related Character of Porcine Bone Marrow Mesenchymal Stem Cells. / 04.2020 / PubMed / Full text
• Extracellular Vesicles of Stem Cells to Prevent BRONJ. / 05.2020 / PubMed / Full text
• Ginsenoside Rg1 as an Effective Regulator of Mesenchymal Stem Cells. / 2019 / PubMed / Full text
• The Importance of Stem Cell Senescence in Regenerative Medicine. / 2020 / PubMed / Full text
• Control of mesenchymal stem cell biology by histone modifications. / 2020 / PubMed / Full text
• Impact of mesenchymal stem cell senescence on inflammaging. / 02.2020 / PubMed / Full text
• Late Rescue Therapy with Cord-Derived Mesenchymal Stromal Cells for Established Lung Injury in Experimental Bronchopulmonary Dysplasia. / 15.03.2020 / PubMed / Full text
• Low-Level Radiofrequency Exposure Does Not Induce Changes in MSC Biology: An in vitro Study for the Prevention of NIR-Related Damage. / 2019 / PubMed / Full text
• Macrophage migration inhibitory factor rejuvenates aged human mesenchymal stem cells and improves myocardial repair. / 27.12.2019 / PubMed / Full text
• Influence of olive oil and its components on mesenchymal stem cell biology. / 26.12.2019 / PubMed / Full text
• Epigenetic Regulation of Mesenchymal Stem Cell Homeostasis. / 02.2020 / PubMed / Full text
• Mesenchymal Stem Cells: Allogeneic MSC May Be Immunosuppressive but Autologous MSC Are Dysfunctional in Lupus Patients. / 2019 / PubMed / Full text
• Effects of high glucose conditions on the expansion and differentiation capabilities of mesenchymal stromal cells derived from rat endosteal niche. / 21.11.2019 / PubMed / Full text
• Autophagy inhibits the mesenchymal stem cell aging induced by D-galactose through ROS/JNK/p38 signalling. / 03.2020 / PubMed / Full text
• Enhancing survival, engraftment, and osteogenic potential of mesenchymal stem cells. / 26.10.2019 / PubMed / Full text
• Mesenchymal stem cell senescence alleviates their intrinsic and seno-suppressive paracrine properties contributing to osteoarthritis development. / 22.10.2019 / PubMed / Full text
• Embryonic stem cell-derived extracellular vesicles enhance the therapeutic effect of mesenchymal stem cells. / 2019 / PubMed / Full text
• Survival of aging CD264 and CD264 populations of human bone marrow mesenchymal stem cells is independent of colony-forming efficiency. / 01.2020 / PubMed / Full text
• Differential effects of extracellular vesicles from aging and young mesenchymal stem cells in acute lung injury. / 29.09.2019 / PubMed / Full text
• Connexin43 is Dispensable for Early Stage Human Mesenchymal Stem Cell Adipogenic Differentiation But is Protective against Cell Senescence. / 11.09.2019 / PubMed / Full text
• Maintained Properties of Aged Dental Pulp Stem Cells for Superior Periodontal Tissue Regeneration. / 08.2019 / PubMed / Full text

SIRT1

• Anthocyanins attenuate endothelial dysfunction through regulation of uncoupling of nitric oxide synthase in aged rats. / 03.12.2020 / PubMed / Full text
• Sirtuins and Their Implications in Neurodegenerative Diseases from a Drug Discovery Perspective. / 05.12.2020 / PubMed / Full text
• Effects of alpha-mangostin on memory senescence induced by high glucose in human umbilical vein endothelial cells. / 10.2020 / PubMed / Full text
• SIRT1 Activation Using CRISPR/dCas9 Promotes Regeneration of Human Corneal Endothelial Cells through Inhibiting Senescence. / 04.11.2020 / PubMed / Full text
• Histone Deacetylase SIRT1, Smooth Muscle Cell Function, and Vascular Diseases. / 2020 / PubMed / Full text
• 6,4'-dihydroxy-7-methoxyflavanone protects against H O -induced cellular senescence by inducing SIRT1 and inhibiting phosphatidylinositol 3-kinase/Akt pathway activation. / 27.10.2020 / PubMed / Full text
• Isoparvifuran isolated from Dalbergia odorifera attenuates H O -induced senescence of BJ cells through SIRT1 activation and AKT/mTOR pathway inhibition. / 30.09.2020 / PubMed / Full text
• SIRT1 Is the Target Gene for 2,3,5,4'-Tetrahydroxystilbene-2-O-β-D-Glucoside Alleviating the HUVEC Senescence. / 2020 / PubMed / Full text
• The Role of Sirtuins in Kidney Diseases. / 12.09.2020 / PubMed / Full text
• The effect of 12-week resistance exercise training on serum levels of cellular aging process parameters in elderly men. / 11.2020 / PubMed / Full text
• Virus-Induced Asthma Exacerbations: SIRT1 Targeted Approach. / 13.08.2020 / PubMed / Full text
• Novel resveratrol derivatives have diverse effects on the survival, proliferation and senescence of primary human fibroblasts. / 12.2020 / PubMed / Full text
• Glucose restriction delays senescence and promotes proliferation of HUVECs via the AMPK/SIRT1-FOXA3-Beclin1 pathway. / 01.10.2020 / PubMed / Full text
• Therapeutic Effects of SRT2104 on Lung Injury in Rats with Emphysema via Reduction of Type II Alveolar Epithelial Cell Senescence. / 08.2020 / PubMed / Full text
• Latifolin Inhibits Oxidative Stress-Induced Senescence via Upregulation of SIRT1 in Human Dermal Fibroblasts. / 01.07.2020 / PubMed / Full text
• SRT1720-induced activation of SIRT1 alleviates vascular smooth muscle cell senescence through PKA-dependent phosphorylation of AMPKα at Ser485. / 07.2020 / PubMed / Full text
• miR-128 plays a critical role in murine osteoclastogenesis and estrogen deficiency-induced bone loss. / 2020 / PubMed / Full text
• Lymphocyte senescence in COPD is associated with decreased sirtuin 1 expression in steroid resistant pro-inflammatory lymphocytes. / 01-12.2020 / PubMed / Full text
• Therapeutic effects of hydro-alcoholic leaf extract of Withania somnifera on age-induced changes in daily rhythms of Sirt1, Nrf2 and Rev-erbα in the SCN of male Wistar rats. / 10.2020 / PubMed / Full text
• The Serum Concentration of Anti-Aging Proteins, Sirtuin1 and αKlotho in Patients with End-Stage Kidney Disease on Maintenance Hemodialysis. / 2020 / PubMed / Full text
• Small extracellular vesicles deliver miR-21 and miR-217 as pro-senescence effectors to endothelial cells. / 2020 / PubMed / Full text
• Spatiotemporal gating of SIRT1 functions by O-GlcNAcylation is essential for liver metabolic switching and prevents hyperglycemia. / 24.03.2020 / PubMed / Full text
• Hydrogen Sulfide Inhibits Homocysteine-Induced Neuronal Senescence by Up-Regulation of SIRT1. / 2020 / PubMed / Full text
• SIRT1 and aging related signaling pathways. / 04.2020 / PubMed / Full text
• Tropisetron protects against brain aging via attenuating oxidative stress, apoptosis and inflammation: The role of SIRT1 signaling. / 01.05.2020 / PubMed / Full text
• Nicotinamide mononucleotide (NMN) supplementation promotes neurovascular rejuvenation in aged mice: transcriptional footprint of SIRT1 activation, mitochondrial protection, anti-inflammatory, and anti-apoptotic effects. / 04.2020 / PubMed / Full text
• Deacetylation of MRTF-A by SIRT1 defies senescence induced down-regulation of collagen type I in fibroblast cells. / 01.05.2020 / PubMed / Full text
• Chronic Polyphenon-60 or Catechin Treatments Increase Brain Monoamines Syntheses and Hippocampal SIRT1 Levels Improving Cognition in Aged Rats. / 26.01.2020 / PubMed / Full text
• Duck Oil-loaded Nanoemulsion Inhibits Senescence of Angiotensin II-treated Vascular Smooth Muscle Cells by Upregulating SIRT1. / 01.2020 / PubMed / Full text
• Two novel SIRT1 activators, SCIC2 and SCIC2.1, enhance SIRT1-mediated effects in stress response and senescence. / 06-07.2020 / PubMed / Full text
• Hydrogen sulfide attenuates mitochondrial dysfunction-induced cellular senescence and apoptosis in alveolar epithelial cells by upregulating sirtuin 1. / 23.12.2019 / PubMed / Full text
• The protective role of omentin-1 in IL-1β-induced chondrocyte senescence. / 12.2020 / PubMed / Full text
• The Lifespan Extension Ability of Nicotinic Acid Depends on Whether the Intracellular NAD Level Is Lower than the Sirtuin-Saturating Concentrations. / 24.12.2019 / PubMed / Full text
• Alpha-mangostin decreased cellular senescence in human umbilical vein endothelial cells. / 06.2020 / PubMed / Full text
• Central nervous system SIRT1 expression is required for cued and contextual fear conditioning memory responses in aging mice. / 23.09.2019 / PubMed / Full text
• Does education level protect us from rapid ageing? Sirtuin expression versus age and level of education. / 10.2019 / PubMed
• CO ameliorates endothelial senescence induced by 5-fluorouracil through SIRT1 activation. / 30.11.2019 / PubMed / Full text
• Long noncoding RNA GAS5 inhibits cell proliferation and fibrosis in diabetic nephropathy by sponging miR-221 and modulating SIRT1 expression. / 20.10.2019 / PubMed / Full text
• The Role of Sirtuin1 in Regulating Endothelial Function, Arterial Remodeling and Vascular Aging. / 2019 / PubMed / Full text
• Deacetylation of LAMP1 drives lipophagy-dependent generation of free fatty acids by Abrus agglutinin to promote senescence in prostate cancer. / 03.2020 / PubMed / Full text
• Plasma exosomes in OSA patients promote endothelial senescence: effect of long-term adherent continuous positive airway pressure. / 13.02.2020 / PubMed / Full text
• Hydrogen Sulfide Inhibits High Glucose-Induced Neuronal Senescence by Improving Autophagic Flux [i]via[/i] Up-regulation of SIRT1. / 2019 / PubMed / Full text
• Activation of the miR-34a-Mediated SIRT1/mTOR Signaling Pathway by Urolithin A Attenuates D-Galactose-Induced Brain Aging in Mice. / 10.2019 / PubMed / Full text

RPE

• Transcriptomic Profiling of Human Pluripotent Stem Cell-derived Retinal Pigment Epithelium over Time. / 08.12.2020 / PubMed / Full text
• Relationship between Oxygen Uptake, Heart Rate, and Perceived Effort in an Aquatic Incremental Test in Older Women. / 11.11.2020 / PubMed / Full text
• Photoreceptor Degeneration in Homozygous Male Per2 Mice During Aging. / 02.11.2020 / PubMed / Full text
• An In-Vitro Cell Model of Intracellular Protein Aggregation Provides Insights into RPE Stress Associated with Retinopathy. / 11.09.2020 / PubMed / Full text
• Short-Term Effect of Self-Selected Training Intensity on Ambulatory Blood Pressure in Hypertensive Older Women: A Randomized Controlled Trial. / 2020 / PubMed / Full text
• Correlation between brain volume and retinal photoreceptor outer segment volume in normal aging and neurodegenerative diseases. / 2020 / PubMed / Full text
• Oxidative stress in the retina and retinal pigment epithelium (RPE): Role of aging, and DJ-1. / 17.07.2020 / PubMed / Full text
• Direct-Coupled Electroretinogram (DC-ERG) for Recording the Light-Evoked Electrical Responses of the Mouse Retinal Pigment Epithelium. / 14.07.2020 / PubMed / Full text
• High-density lipoproteins are a potential therapeutic target for age-related macular degeneration. / 25.09.2020 / PubMed / Full text
• MTOR-initiated metabolic switch and degeneration in the retinal pigment epithelium. / 09.2020 / PubMed / Full text
• [i]Lactobacillus paracasei[/i] KW3110 Suppresses Inflammatory Stress-Induced Premature Cellular Senescence of Human Retinal Pigment Epithelium Cells and Reduces Ocular Disorders in Healthy Humans. / 18.07.2020 / PubMed / Full text
• Retinal pigment epithelium transcriptome analysis in chronic smoking reveals a suppressed innate immune response and activation of differentiation pathways. / 20.08.2020 / PubMed / Full text
• Differences in Intraretinal Pigment Migration Across Inherited Retinal Dystrophies. / 09.2020 / PubMed / Full text
• Exosomal MiRNA Transfer between Retinal Microglia and RPE. / 17.05.2020 / PubMed / Full text
• Functionally validated imaging endpoints in the Alabama study on early age-related macular degeneration 2 (ALSTAR2): design and methods. / 19.05.2020 / PubMed / Full text
• Mechanisms of mitochondrial dysfunction and their impact on age-related macular degeneration. / 13.04.2020 / PubMed / Full text
• CSF1R blockade induces macrophage ablation and results in mouse choroidal vascular atrophy and RPE disorganization. / 01.04.2020 / PubMed / Full text
• Extracellular microparticles exacerbate oxidative damage to retinal pigment epithelial cells. / 01.05.2020 / PubMed / Full text
• Water-based continuous and interval training in older women: Cardiorespiratory and neuromuscular outcomes (WATER study). / 05.03.2020 / PubMed / Full text
• Retrieval Practice Improves Recollection-Based Memory Over a Seven-Day Period in Younger and Older Adults. / 2019 / PubMed / Full text
• A Comparison of Heart Rate Training Load and Perceptual Effort Between Masters and Young Cyclists / 01.05.2020 / PubMed / Full text
• Retinal Pigment Epithelial Cells: The Unveiled Component in the Etiology of Prpf Splicing Factor-Associated Retinitis Pigmentosa. / 2019 / PubMed / Full text
• AMPK May Play an Important Role in the Retinal Metabolic Ecosystem. / 2019 / PubMed / Full text
• Stem cell-derived retinal pigment epithelium from patients with age-related macular degeneration exhibit reduced metabolism and matrix interactions. / 03.2020 / PubMed / Full text
• Elovanoids counteract oligomeric β-amyloid-induced gene expression and protect photoreceptors. / 26.11.2019 / PubMed / Full text
• Genetic LAMP2 deficiency accelerates the age-associated formation of basal laminar deposits in the retina. / 19.11.2019 / PubMed / Full text
• Age, lipofuscin and melanin oxidation affect fundus near-infrared autofluorescence. / 10.2019 / PubMed / Full text
• Relevance of working memory for reinforcement learning in older adults varies with timescale of learning. / 09.2020 / PubMed / Full text
• Expression and Function of Mas-Related G Protein-Coupled Receptor D and Its Ligand Alamandine in Retina. / 01.2020 / PubMed / Full text

CRP

• Omega-3 supplementation improves isometric strength but not muscle anabolic and catabolic signaling in response to resistance exercise in healthy older adults. / 07.12.2020 / PubMed / Full text
• Circulating angiopoietin-like protein 2 levels and arterial stiffness in patients receiving maintenance hemodialysis: A cross-sectional study. / 02.11.2020 / PubMed / Full text
• Cardiovascular rehabilitation in patients aged 70-year-old or older: benefits on functional capacity, physical activity and metabolic profile in younger [i]vs[/i]. older patients. / 28.09.2020 / PubMed / Full text
• rRT-PCR Results of a Covid-19 Diagnosed Geriatric Patient. / 17.10.2020 / PubMed / Full text
• The Association of Aging Biomarkers, Interstitial Lung Abnormalities, and Mortality. / 20.10.2020 / PubMed / Full text
• A Novel Fortified Dairy Product and Sarcopenia Measures in Sarcopenic Older Adults: A Double-Blind Randomized Controlled Trial. / 13.10.2020 / PubMed / Full text
• Age-Related Colonic Mucosal Microbiome Community Shifts in Monkeys. / 06.10.2020 / PubMed / Full text
• The relationship between frailty and serum alpha klotho levels in geriatric patients. / 08.08.2020 / PubMed / Full text
• ZMPSTE24 Is Associated with Elevated Inflammation and Progerin mRNA. / 28.08.2020 / PubMed / Full text
• Cultural and life style practices associated with low inflammatory physiology in Japanese adults. / 11.2020 / PubMed / Full text
• Moderate- to high intensity aerobic and resistance exercise reduces peripheral blood regulatory cell populations in older adults with rheumatoid arthritis. / 2020 / PubMed / Full text
• PTSD and the klotho longevity gene: Evaluation of longitudinal effects on inflammation via DNA methylation. / 07.2020 / PubMed / Full text
• Bereavement is associated with reduced systemic inflammation: C-reactive protein before and after widowhood. / 08.2020 / PubMed / Full text
• The Impact of Age on the Prevalence of Sarcopenic Obesity in Bariatric Surgery Candidates. / 06.2020 / PubMed / Full text
• Intake of dietary advanced glycation end products influences inflammatory markers, immune phenotypes, and antiradical capacity of healthy elderly in a little-studied population. / 02.2020 / PubMed / Full text
• Intentional Switching Between Bimanual Coordination Patterns in Older Adults: Is It Mediated by Inhibition Processes? / 2020 / PubMed / Full text
• Shorter Telomere Length in Peripheral Blood Leukocytes Is Associated with Post-Traumatic Chronic Osteomyelitis. / 11.2020 / PubMed / Full text
• Risk Factors of Progression to Frailty: Findings from the Singapore Longitudinal Ageing Study. / 2020 / PubMed / Full text
• Physical Function and Strength in Relation to Inflammation in Older Adults with Obesity and Increased Cardiometabolic Risk. / 2019 / PubMed / Full text
• Key diagnostic characteristics of fever of unknown origin in Japanese patients: a prospective multicentre study. / 19.11.2019 / PubMed / Full text
• Decrease in Serum Vitamin D Level of Older Patients with Fatigue. / 20.10.2019 / PubMed / Full text
• The Association between Frailty Indicators and Blood-Based Biomarkers in Early-Old Community Dwellers of Thailand. / 17.09.2019 / PubMed / Full text
• Associations of C-reactive protein and homocysteine concentrations with the impairment of intrinsic capacity domains over a 5-year follow-up among community-dwelling older adults at risk of cognitive decline (MAPT Study). / 11.2019 / PubMed / Full text
• Longitudinal analysis of loneliness and inflammation at older ages: English longitudinal study of ageing. / 12.2019 / PubMed / Full text
• The cortisol burden in elderly subjects with metabolic syndrome and its association with low-grade inflammation. / 07.2020 / PubMed / Full text
• Recurrent circadian fasting (RCF) improves blood pressure, biomarkers of cardiometabolic risk and regulates inflammation in men. / 19.08.2019 / PubMed / Full text
• Characteristics of patients with rheumatoid arthritis undergoing primary total joint replacement: A 14-year trend analysis (2004-2017). / 07.2020 / PubMed / Full text

CA1

• The relation between tau pathology and granulovacuolar degeneration of neurons. / 01.2021 / PubMed / Full text
• Memory and dendritic spines loss, and dynamic dendritic spines changes are age-dependent in the rat. / 12.2020 / PubMed / Full text
• Deregulated expression of a longevity gene, Klotho, in the C9orf72 deletion mice with impaired synaptic plasticity and adult hippocampal neurogenesis. / 04.09.2020 / PubMed / Full text
• COX5A Plays a Vital Role in Memory Impairment Associated With Brain Aging [i]via[/i] the BDNF/ERK1/2 Signaling Pathway. / 2020 / PubMed / Full text
• Changes of fat-mass and obesity-associated protein expression in the hippocampus in animal models of high-fat diet-induced obesity and D-galactose-induced aging. / 2020 / PubMed / Full text
• Phenylbutyrate ameliorates prefrontal cortex, hippocampus, and nucleus accumbens neural atrophy as well as synaptophysin and GFAP stress in aging mice. / 11.2020 / PubMed / Full text
• Heterogeneity in brain distribution of activated microglia and astrocytes in a rat ischemic model of Alzheimer's disease after 2 years of survival. / 05.06.2020 / PubMed / Full text
• Hippocampal Subregion Transcriptomic Profiles Reflect Strategy Selection during Cognitive Aging. / 17.06.2020 / PubMed / Full text
• Associations between pattern separation and hippocampal subfield structure and function vary along the lifespan: A 7 T imaging study. / 05.05.2020 / PubMed / Full text
• Laminarin Pretreatment Provides Neuroprotection against Forebrain Ischemia/Reperfusion Injury by Reducing Oxidative Stress and Neuroinflammation in Aged Gerbils. / 15.04.2020 / PubMed / Full text
• Age-dependent Alteration in Mitochondrial Dynamics and Autophagy in Hippocampal Neuron of Cannabinoid CB1 Receptor-deficient Mice. / 07.2020 / PubMed / Full text
• Functional Connectivity of Hippocampal CA3 Predicts Neurocognitive Aging via CA1-Frontal Circuit. / 30.06.2020 / PubMed / Full text
• Integration of qRT-PCR and Immunohistochemical Techniques for mRNA Expression and Localization of m1AChR in the Brain of Aging Rat. / 2020 / PubMed / Full text
• Role of Eclipta prostrata extract in improving spatial learning and memory deficits in D-galactose-induced aging in rats. / 10.2019 / PubMed
• Differential annualized rates of hippocampal subfields atrophy in aging and future Alzheimer's clinical syndrome. / 06.2020 / PubMed / Full text
• Rectification of radiotherapy-induced cognitive impairments in aged mice by reconstituted Sca-1 stem cells from young donors. / 07.02.2020 / PubMed / Full text
• Increasing neurogenesis refines hippocampal activity rejuvenating navigational learning strategies and contextual memory throughout life. / 09.01.2020 / PubMed / Full text
• Memory Performance Correlates of Hippocampal Subfield Volume in Mild Cognitive Impairment Subtype. / 2019 / PubMed / Full text
• Spermidine protects from age-related synaptic alterations at hippocampal mossy fiber-CA3 synapses. / 23.12.2019 / PubMed / Full text
• Methylene blue inhibits Caspase-6 activity, and reverses Caspase-6-induced cognitive impairment and neuroinflammation in aged mice. / 16.12.2019 / PubMed / Full text
• Long-term Memory Upscales Volume of Postsynaptic Densities in the Process that Requires Autophosphorylation of αCaMKII. / 14.04.2020 / PubMed / Full text
• PACAP27 mitigates an age-dependent hippocampal vulnerability to PGJ2-induced spatial learning deficits and neuroinflammation in mice. / 01.2020 / PubMed / Full text
• Inhibition of oxidative stress by testosterone improves synaptic plasticity in senescence accelerated mice. / 2019 / PubMed / Full text
• Restored presynaptic synaptophysin and cholinergic inputs contribute to the protective effects of physical running on spatial memory in aged mice. / 12.2019 / PubMed / Full text
• Senescent neurophysiology: Ca signaling from the membrane to the nucleus. / 10.2019 / PubMed / Full text

GC

• Body Size and Cuticular Hydrocarbons as Larval Age Indicators in the Forensic Blow Fly, Chrysomya albiceps (Diptera: Calliphoridae). / 04.12.2020 / PubMed / Full text
• Composition of peony petal fatty acids and flavonoids and their effect on Caenorhabditis elegans lifespan. / 10.2020 / PubMed / Full text
• Photo aging and fragmentation of polypropylene food packaging materials in artificial seawater. / 01.01.2021 / PubMed / Full text
• Secretory galectin-3 induced by glucocorticoid stress triggers stemness exhaustion of hepatic progenitor cells. / 04.12.2020 / PubMed / Full text
• Optimization of Ethanol Detection by Automatic Headspace Method for Cellulose Insulation Aging of Oil-immersed Transformers. / 15.07.2020 / PubMed / Full text
• Sensory, olfactometric and chemical characterization of the aroma potential of Garnacha and Tempranillo winemaking grapes. / 30.11.2020 / PubMed / Full text
• Accelerated Cognitive Ageing in epilepsy: exploring the effective connectivity between resting-state networks and its relation to cognitive decline. / 06.2020 / PubMed / Full text
• Characterization of Jinhua ham aroma profiles in specific to aging time by gas chromatography-ion mobility spectrometry (GC-IMS). / 10.2020 / PubMed / Full text
• Quantitative Profiling of Lipid Species in Caenorhabditis elegans with Gas Chromatography-Mass Spectrometry. / 2020 / PubMed / Full text
• Physicochemical characterization of a polysaccharide from Agrocybe aegirita and its anti-ageing activity. / 15.05.2020 / PubMed / Full text
• Structural characteristics, antioxidant properties and antiaging activities of galactan produced by Mentha haplocalyx Briq. / 15.04.2020 / PubMed / Full text
• Contribution of Volatile Odorous Terpenoid Compounds to Aged Cognac Spirits Aroma in a Context of Multicomponent Odor Mixtures. / 25.11.2020 / PubMed / Full text
• Plasma Formate Is Greater in Fetal and Neonatal Rats Compared with Their Mothers. / 01.05.2020 / PubMed / Full text
• Development of a new strategy for studying the aroma potential of winemaking grapes through the accelerated hydrolysis of phenolic and aromatic fractions (PAFs). / 01.2020 / PubMed / Full text
• Compromised steady-state germinal center activity with age in nonhuman primates. / 02.2020 / PubMed / Full text
• Endogenous Glucocorticoid Signaling in the Regulation of Bone and Marrow Adiposity: Lessons from Metabolism and Cross Talk in Other Tissues. / 12.2019 / PubMed / Full text
• 4,5-Diphenyl-2-methyl picolinate induces cellular senescence by accumulating DNA damage and activating associated signaling pathways in gastric cancer. / 01.12.2019 / PubMed / Full text
• Relationship Between the Dose Administered, Target Tissue Dose, and Toxicity Level After Acute Oral Exposure to Bifenthrin and Tefluthrin in Young Adult Rats. / 01.12.2019 / PubMed / Full text
• Sugar Beet Pectin Supplementation Did Not Alter Profiles of Fecal Microbiota and Exhaled Breath in Healthy Young Adults and Healthy Elderly. / 12.09.2019 / PubMed / Full text
• Identification and analysis of new α- and β-hydroxy ketones related to the formation of 3-methyl-2,4-nonanedione in musts and red wines. / 01.02.2020 / PubMed / Full text
• Neonatal T Follicular Helper Cells Are Lodged in a Pre-T Follicular Helper Stage Favoring Innate Over Adaptive Germinal Center Responses. / 2019 / PubMed / Full text
• Identification of Dialkylpyrazines Off-Flavors in Oak Wood. / 11.09.2019 / PubMed / Full text
• Metabolomics Coupled with Transcriptomics Approach Deciphering Age Relevance in Sepsis. / 08.2019 / PubMed / Full text

NLRP3

• Innate and Adaptive Immunity in Aging and Longevity: The Foundation of Resilience. / 12.2020 / PubMed / Full text
• TET2-Loss-of-Function-Driven Clonal Hematopoiesis Exacerbates Experimental Insulin Resistance in Aging and Obesity. / 27.10.2020 / PubMed / Full text
• Repeated propofol exposure-induced neuronal damage and cognitive impairment in aged rats by activation of NF-κB pathway and NLRP3 inflammasome. / 01.01.2021 / PubMed / Full text
• A Small Molecule Stabilizer of the MYC G4-Quadruplex Induces Endoplasmic Reticulum Stress, Senescence and Pyroptosis in Multiple Myeloma. / 13.10.2020 / PubMed / Full text
• Interleukin-1β Drives Cellular Senescence of Rat Astrocytes Induced by Oligomerized Amyloid β Peptide and Oxidative Stress. / 2020 / PubMed / Full text
• Mechanisms of NLRP3 priming in inflammaging and age related diseases. / 10.2020 / PubMed / Full text
• Lamivudine Inhibits [i]Alu[/i] RNA-induced Retinal Pigment Epithelium Degeneration via Anti-inflammatory and Anti-senescence Activities. / 07.2020 / PubMed / Full text
• The NLRP3 Inflammasome: Metabolic Regulation and Contribution to Inflammaging. / 30.07.2020 / PubMed / Full text
• Aging aggravated liver ischemia and reperfusion injury by promoting STING-mediated NLRP3 activation in macrophages. / 08.2020 / PubMed / Full text
• Targeting NLRP3 Inflammasome Reduces Age-Related Experimental Alveolar Bone Loss. / 10.2020 / PubMed / Full text
• Korean Red Ginseng Suppresses the Expression of Oxidative Stress Response and NLRP3 Inflammasome Genes in Aged C57BL/6 Mouse Ovaries. / 22.04.2020 / PubMed / Full text
• Cepharanthine promotes the effect of dexmedetomidine on the deposition of β-amyloid in the old age of the senile dementia rat model by regulating inflammasome expression. / 2019 / PubMed / Full text
• Ginsenoside Rg1 ameliorates glomerular fibrosis during kidney aging by inhibiting NOX4 and NLRP3 inflammasome activation in SAMP8 mice. / 27.02.2020 / PubMed / Full text
• Blockade of the NLRP3 inflammasome improves metabolic health and lifespan in obese mice. / 04.2020 / PubMed / Full text
• Autophagy and NLRP3 inflammasome crosstalk in neuroinflammation in aged bovine brains. / 06.2020 / PubMed / Full text
• NLRP3 Inflammasome Inhibition by MCC950 in Aged Mice Improves Health via Enhanced Autophagy and PPARα Activity. / 13.07.2020 / PubMed / Full text
• NLRP3 inflammasome suppression improves longevity and prevents cardiac aging in male mice. / 01.2020 / PubMed / Full text
• Reduced NRF2 expression suppresses endothelial progenitor cell function and induces senescence during aging. / 08.09.2019 / PubMed / Full text
• Effect of Aging on Taurine Transporter (TauT) Expression in the Mouse Brain Cortex. / 2019 / PubMed / Full text

SCD

• Cognitive training and brain stimulation in prodromal Alzheimer's disease (AD-Stim)-study protocol for a double-blind randomized controlled phase IIb (monocenter) trial. / 07.11.2020 / PubMed / Full text
• Blood Pressure in Different Dementia Disorders, Mild Cognitive Impairment, and Subjective Cognitive Decline. / 2020 / PubMed / Full text
• Known-Groups and Convergent Validity of the Telephone Rey Auditory Verbal Learning Test total Learning Scores for Distinguishing Between Older Adults With Amnestic Cognitive Impairment and Subjective Cognitive Decline. / 17.10.2020 / PubMed / Full text
• Subjective cognitive decline as a predictor of future cognitive decline: a systematic review. / 07-09.2020 / PubMed / Full text
• Geriatric assessment for older adults with sickle cell disease: protocol for a prospective cohort pilot study. / 2020 / PubMed / Full text
• Prevalence and psychosocial correlates of subjectively perceived decline in five cognitive domains: Results from a population-based cohort study in Germany. / 08.06.2020 / PubMed / Full text
• SC411 treatment can enhance survival in a mouse model of sickle cell disease. / 07.2020 / PubMed / Full text
• DNA fragmentation of human spermatozoa: Simple assessment of single- and double-strand DNA breaks and their respective dynamic behavioral response. / 09.2020 / PubMed / Full text
• Psychometric Cognitive Decline Precedes the Advent of Subjective Cognitive Decline in the Evolution of Alzheimer's Disease. / 2020 / PubMed / Full text
• Serum alkaline phosphatase is elevated and inversely correlated with cognitive functions in subjective cognitive decline: results from the ReGAl 2.0 project. / 03.05.2020 / PubMed / Full text
• Changes in Activity Participation Among Older Adults With Subjective Cognitive Decline or Objective Cognitive Deficits. / 2019 / PubMed / Full text
• Age, gender and drug therapy influences on Tpeak-tend interval and on electrical risk score. / 03-04.2020 / PubMed / Full text
• Comorbid Chronic Conditions Among Older Adults with Subjective Cognitive Decline, United States, 2015-2017. / 2020 / PubMed / Full text
• Resting State BOLD Variability Is Linked to White Matter Vascular Burden in Healthy Aging but Not in Older Adults With Subjective Cognitive Decline. / 2019 / PubMed / Full text
• Estimated Life Expectancy and Income of Patients With Sickle Cell Disease Compared With Those Without Sickle Cell Disease. / 01.11.2019 / PubMed / Full text
• Does Empirically Derived Classification of Individuals with Subjective Cognitive Complaints Predict Dementia? / 07.11.2019 / PubMed / Full text
• Spatiotemporal Oscillatory Patterns During Working Memory Maintenance in Mild Cognitive Impairment and Subjective Cognitive Decline. / 01.2020 / PubMed / Full text
• Microstructural Correlates and Laterality Effect of Prospective Memory in Non-Demented Adults with Memory Complaints. / 2019 / PubMed / Full text

BDNF

• Influence of [i]BDNF[/i] Genetic Polymorphisms in the Pathophysiology of Aging-related Diseases. / 12.2020 / PubMed / Full text
• Moderators of the Impact of (Poly)Phenols Interventions on Psychomotor Functions and BDNF: Insights from Subgroup Analysis and Meta-Regression. / 19.09.2020 / PubMed / Full text
• Astroglia-Derived BDNF and MSK-1 Mediate Experience- and Diet-Dependent Synaptic Plasticity. / 18.07.2020 / PubMed / Full text
• BDNF reverses aging-related microglial activation. / 14.07.2020 / PubMed / Full text
• High Supervised Resistance Training in Elderly Women: The Role of Supervision Ratio. / 2020 / PubMed / Full text
• Metformin regulates astrocyte reactivity in Parkinson's disease and normal aging. / 15.09.2020 / PubMed / Full text
• Aging-Induced Brain-Derived Neurotrophic Factor in Adipocyte Progenitors Contributes to Adipose Tissue Dysfunction. / 05.2020 / PubMed / Full text
• The Role of BDNF on Aging-Modulation Markers. / 09.05.2020 / PubMed / Full text
• Spermidine and spermine delay brain aging by inducing autophagy in SAMP8 mice. / 08.04.2020 / PubMed / Full text
• Microglia senescence occurs in both substantia nigra and ventral tegmental area. / 11.2020 / PubMed / Full text
• Towards an understanding of the physical activity-BDNF-cognition triumvirate: A review of associations and dosage. / 07.2020 / PubMed / Full text
• Impact of BDNF and sex on maintaining intact memory function in early midlife. / 04.2020 / PubMed / Full text
• Testosterone replacement causes dose-dependent improvements in spatial memory among aged male rats. / 03.2020 / PubMed / Full text
• The effects of aerobic exercise intensity on memory in older adults. / 06.2020 / PubMed / Full text
• Protective effects of vitamin D on neurophysiologic alterations in brain aging: role of brain-derived neurotrophic factor (BDNF). / 16.09.2019 / PubMed / Full text
• Differential Effects of Physical Exercise, Cognitive Training, and Mindfulness Practice on Serum BDNF Levels in Healthy Older Adults: A Randomized Controlled Intervention Study. / 2019 / PubMed / Full text
• Dietary Supplementation with Fish Oil or Conjugated Linoleic Acid Relieves Depression Markers in Mice by Modulation of the Nrf2 Pathway. / 11.2019 / PubMed / Full text

TERT

• Telomeres and telomerase in risk assessment of cardiovascular diseases. / 15.12.2020 / PubMed / Full text
• A 4-Base-Pair Core-Enclosing Helix in Telomerase RNA Is Essential for Activity and for Binding to the Telomerase Reverse Transcriptase Catalytic Protein Subunit. / 20.11.2020 / PubMed / Full text
• Angiotensin inhibition and cellular senescence in the developing rat kidney. / 12.2020 / PubMed / Full text
• Decreased expression of TERT and telomeric proteins as human ovaries age may cause telomere shortening. / 27.08.2020 / PubMed / Full text
• The secrets of telomerase: Retrospective analysis and future prospects. / 15.09.2020 / PubMed / Full text
• Gene expression in human mesenchymal stem cell aging cultures: modulation by short peptides. / 06.2020 / PubMed / Full text
• Unravelling Cellular Mechanisms of Stem Cell Senescence: An Aid from Natural Bioactive Molecules. / 20.03.2020 / PubMed / Full text
• Expression of telomerase reverse transcriptase positively correlates with duration of lithium treatment in bipolar disorder. / 04.2020 / PubMed / Full text
• FAM96B inhibits the senescence of dental pulp stem cells. / 05.2020 / PubMed / Full text
• Aging and biomarkers: Transcriptional levels evaluation of Osteopontin/miRNA-181a axis in hepatic tissue of rats in different age ranges. / 05.2020 / PubMed / Full text
• Resveratrol inhibits adipocyte differentiation and cellular senescence of human bone marrow stromal stem cells. / 04.2020 / PubMed / Full text
• Characterization of human telomerase reverse transcriptase immortalized anterior cruciate ligament cell lines. / 12.2019 / PubMed / Full text
• Mitochondria, Telomeres and Telomerase Subunits. / 2019 / PubMed / Full text
• Towards Therapeutic Alternatives for Mercury Neurotoxicity in the Amazon: Unraveling the Pre-Clinical Effects of the Superfruit Açaí ([i]Euterpe oleracea[/i], Mart.) as Juice for Human Consumption. / 26.10.2019 / PubMed / Full text
• Replication Stress at Telomeric and Mitochondrial DNA: Common Origins and Consequences on Ageing. / 08.10.2019 / PubMed / Full text
• Telomerase Biology Associations Offer Keys to Cancer and Aging Therapeutics. / 2020 / PubMed / Full text
• Transient induction of telomerase expression mediates senescence and reduces tumorigenesis in primary fibroblasts. / 17.09.2019 / PubMed / Full text

PGC

• The Aging Stress Response and Its Implication for AMD Pathogenesis. / 22.11.2020 / PubMed / Full text
• Constitutive PGC-1α Overexpression in Skeletal Muscle Does Not Contribute to Exercise-Induced Neurogenesis. / 16.11.2020 / PubMed / Full text
• Dysregulated Autophagy Mediates Sarcopenic Obesity and Its Complications via AMPK and PGC1α Signaling Pathways: Potential Involvement of Gut Dysbiosis as a Pathological Link. / 19.09.2020 / PubMed / Full text
• Resemblance and differences in dietary restriction nephroprotective mechanisms in young and old rats. / 24.09.2020 / PubMed / Full text
• Acute and chronic effects of resistance training on skeletal muscle markers of mitochondrial remodeling in older adults. / 08.2020 / PubMed / Full text
• PGC-1α-mediated regulation of mitochondrial function and physiological implications. / 09.2020 / PubMed / Full text
• Targeting Mitochondrial Network Architecture in Down Syndrome and Aging. / 29.04.2020 / PubMed / Full text
• Colchicine treatment impairs skeletal muscle mitochondrial function and insulin sensitivity in an age-specific manner. / 06.2020 / PubMed / Full text
• A novel dipeptide from potato protein hydrolysate augments the effects of exercise training against high-fat diet-induced damages in senescence-accelerated mouse-prone 8 by boosting pAMPK / SIRT1/ PGC-1α/ pFOXO3 pathway. / 26.04.2020 / PubMed / Full text
• Mitochondrial nucleoid remodeling and biogenesis are regulated by the p53-p21 -PKCζ pathway in p16 -silenced cells. / 24.04.2020 / PubMed / Full text
• [Metabolic Alteration in Aging Process: Metabolic Remodeling in White Adipose Tissue by Caloric Restriction]. / 2020 / PubMed / Full text
• Kynurenine aminotransferase isoforms display fiber-type specific expression in young and old human skeletal muscle. / 15.02.2020 / PubMed / Full text
• Ubiquinol-10 delays postovulatory oocyte aging by improving mitochondrial renewal in pigs. / 20.01.2020 / PubMed / Full text
• Mitochondrial oxidative capacity and NAD biosynthesis are reduced in human sarcopenia across ethnicities. / 20.12.2019 / PubMed / Full text
• MicroRNA-34a (miR-34a) Mediates Retinal Endothelial Cell Premature Senescence through Mitochondrial Dysfunction and Loss of Antioxidant Activities. / 22.08.2019 / PubMed / Full text
• Constitutive PGC-1α overexpression in skeletal muscle does not protect from age-dependent decline in neurogenesis. / 23.08.2019 / PubMed / Full text

CD28

• Premature CD4 T Cells Senescence Induced by Chronic Infection in Patients with Acute Coronary Syndrome. / 12.2020 / PubMed / Full text
• The IMMENSE Study: The Interplay Between iMMune and ENdothelial Cells in Mediating Cardiovascular Risk in Systemic Lupus Erythematosus. / 2020 / PubMed / Full text
• Emergence of T cell immunosenescence in diabetic chronic kidney disease. / 2020 / PubMed / Full text
• The relationship between Chlamydia pneumoniae infection and CD4/CD8 ratio, lymphocyte subsets in middle-aged and elderly individuals. / 12.2020 / PubMed / Full text
• Next steps in mechanisms of inflammaging. / 22.09.2020 / PubMed / Full text
• A randomized pilot trial to evaluate the benefit of the concomitant use of atorvastatin and Raltegravir on immunological markers in protease-inhibitor-treated subjects living with HIV. / 2020 / PubMed / Full text
• Aging affects responsiveness of peripheral blood mononuclear cells to immunosuppression of periodontal ligament stem cells. / 07.2020 / PubMed / Full text
• Comparison of Donepezil, Memantine, Melatonin, and Liuwei Dihuang Decoction on Behavioral and Immune Endocrine Responses of Aged Senescence-Accelerated Mouse Resistant 1 Mice. / 2020 / PubMed / Full text
• Immunosenescent characteristics of T cells in young patients following haploidentical haematopoietic stem cell transplantation from parental donors. / 04.2020 / PubMed / Full text
• Diagnosis-independent loss of T-cell costimulatory molecules in individuals with cytomegalovirus infection. / 07.2020 / PubMed / Full text
• Accelerated immunosenescence in rheumatoid arthritis: impact on clinical progression. / 2020 / PubMed / Full text
• Accelerated immune aging was correlated with lupus-associated brain fog in reproductive-age systemic lupus erythematosus patients. / 05.2020 / PubMed / Full text
• T cells, aging and senescence. / 22.02.2020 / PubMed / Full text
• Liver fibrosis and accelerated immune dysfunction (immunosenescence) among HIV-infected Russians with heavy alcohol consumption - an observational cross-sectional study. / 31.12.2019 / PubMed / Full text
• Effect of Allogenic Bone Marrow Mesenchymal Stem Cell Transplantation on T Cells of Old Mice. / 02.2020 / PubMed / Full text
• Peripheral antibody concentrations are associated with highly differentiated T cells and inflammatory processes in the human bone marrow. / 2019 / PubMed / Full text

HGS

• Handgrip strength asymmetry is associated with future falls in older Americans. / 27.11.2020 / PubMed / Full text
• Examining Additional Aspects of Muscle Function with a Digital Handgrip Dynamometer and Accelerometer in Older Adults: A Pilot Study. / 31.10.2020 / PubMed / Full text
• The Relationship between Muscular Strength and Depression in Older Adults with Chronic Disease Comorbidity. / 18.09.2020 / PubMed / Full text
• Handgrip Strength in the Korean Population: Normative Data and Cutoff Values. / 12.2019 / PubMed / Full text
• Handgrip Strength Asymmetry and Weakness Are Associated with Lower Cognitive Function: A Panel Study. / 09.2020 / PubMed / Full text
• Handgrip Strength Asymmetry and Weakness are Differentially Associated with Functional Limitations in Older Americans. / 06.05.2020 / PubMed / Full text
• Absolute and Body Mass Index Normalized Handgrip Strength Percentiles by Gender, Ethnicity, and Hand Dominance in Americans. / 2020 / PubMed / Full text
• Hand grip strength variability during serial testing as an entropic biomarker of aging: a Poincaré plot analysis. / 13.01.2020 / PubMed / Full text
• Physical Activity and Fitness in White- and Blue-Collar Retired Men. / 11-12.2019 / PubMed / Full text
• Association between Hand Grip Strength and Self-Rated Health in Middle- and Old-Aged Korean Citizens. / 01.2020 / PubMed / Full text
• Weakness May Have a Causal Association With Early Mortality in Older Americans: A Matched Cohort Analysis. / 05.2020 / PubMed / Full text
• Associations Between Dietary Patterns and Handgrip Strength: The Korea National Health and Nutrition Examination Survey 2014-2016. / 08.2020 / PubMed / Full text
• Effect of relative handgrip strength on cardiovascular disease among Korean adults aged 45 years and older: Results from the Korean Longitudinal Study of Aging (2006-2016). / 01-02.2020 / PubMed / Full text
• Weakness and cognitive impairment are independently and jointly associated with functional decline in aging Americans. / 09.2020 / PubMed / Full text
• Association of phase angle with sarcopenia and its components in physically active older women. / 08.2020 / PubMed / Full text

CS

• Acute effect of bodyweight-based strength training on blood pressure of hypertensive older adults: A randomized crossover clinical trial. / 16.11.2020 / PubMed / Full text
• Particle growth with photochemical age from new particle formation to haze in the winter of Beijing, China. / 20.01.2021 / PubMed / Full text
• Effect of aging on stabilization of Cd and Ni by biochars and enzyme activities in a historically contaminated alkaline agricultural soil simulated with wet-dry and freeze-thaw cycling. / 27.10.2020 / PubMed / Full text
• Cockayne syndrome proteins CSA and CSB maintain mitochondrial homeostasis through NAD signaling. / 09.11.2020 / PubMed / Full text
• Vision Impairment and Participation in Cognitively Stimulating Activities: The Health ABC Study. / 25.07.2020 / PubMed / Full text
• Suspension training vs. traditional resistance training: effects on muscle mass, strength and functional performance in older adults. / 10.2020 / PubMed / Full text
• Generational Differences in the 10-year Incidence of Impaired Contrast Sensitivity. / 21.07.2020 / PubMed / Full text
• Inducible aging in Hydra oligactis implicates sexual reproduction, loss of stem cells, and genome maintenance as major pathways. / 08.2020 / PubMed / Full text
• Noradrenergic Responsiveness Supports Selective Attention across the Adult Lifespan. / 27.05.2020 / PubMed / Full text
• Cellular senescence: from anti-cancer weapon to anti-aging target. / 03.2020 / PubMed / Full text
• Extra-mitochondrial citrate synthase initiates calcium oscillation and suppresses age-dependent sperm dysfunction. / 04.2020 / PubMed / Full text
• Pathogenesis of chronic obstructive pulmonary disease (COPD) induced by cigarette smoke. / 10.2019 / PubMed / Full text
• Possible Role of Amyloid Cross-Seeding in Evolvability and Neurodegenerative Disease. / 2019 / PubMed / Full text
• Targeting p16-induced senescence prevents cigarette smoke-induced emphysema by promoting IGF1/Akt1 signaling in mice. / 2019 / PubMed / Full text

ACE2

• How Does SARS-CoV-2 Affect the Central Nervous System? A Working Hypothesis. / 2020 / PubMed / Full text
• Bioinformatic characterization of angiotensin-converting enzyme 2, the entry receptor for SARS-CoV-2. / 2020 / PubMed / Full text
• A mouse-adapted model of SARS-CoV-2 to test COVID-19 countermeasures. / 10.2020 / PubMed / Full text
• COVID-19 and Senotherapeutics: Any Role for the Naturally-occurring Dipeptide Carnosine? / 07.2020 / PubMed / Full text
• The dual impact of ACE2 in COVID-19 and ironical actions in geriatrics and pediatrics with possible therapeutic solutions. / 15.09.2020 / PubMed / Full text
• The possible pathophysiology mechanism of cytokine storm in elderly adults with COVID-19 infection: the contribution of "inflame-aging". / 09.2020 / PubMed / Full text
• Decoding SARS-CoV-2 hijacking of host mitochondria in COVID-19 pathogenesis. / 01.08.2020 / PubMed / Full text
• A Mouse Model of SARS-CoV-2 Infection and Pathogenesis. / 08.07.2020 / PubMed / Full text
• COVID-19-associated cardiovascular morbidity in older adults: a position paper from the Italian Society of Cardiovascular Researches. / 08.2020 / PubMed / Full text
• Gut microbiota and Covid-19- possible link and implications. / 08.2020 / PubMed / Full text
• Inflamm-aging: Why older men are the most susceptible to SARS-CoV-2 complicated outcomes. / 06.2020 / PubMed / Full text
• Restoration of the Renin-Angiotensin System Balance Is a Part of the Effect of Fasting on Cardiovascular Rejuvenation: Role of Age and Fasting Models. / 08.2020 / PubMed / Full text
• Angiotensin 1-7 alleviates aging-associated muscle weakness and bone loss, but is not associated with accelerated aging in ACE2-knockout mice. / 30.09.2019 / PubMed / Full text

STAT3

• Dietary Restriction Suppresses Steatosis-Associated Hepatic Tumorigenesis in Hepatitis C Virus Core Gene Transgenic Mice. / 09.2020 / PubMed / Full text
• Skeletal glucocorticoid signalling determines leptin resistance and obesity in aging mice. / 12.2020 / PubMed / Full text
• AMPK alleviates oxidative stress‑induced premature senescence via inhibition of NF-κB/STAT3 axis-mediated positive feedback loop. / 10.2020 / PubMed / Full text
• Age-related loss of neural stem cell O-GlcNAc promotes a glial fate switch through STAT3 activation. / 08.09.2020 / PubMed / Full text
• Cell Death by Gallotannin Is Associated with Inhibition of the JAK/STAT Pathway in Human Colon Cancer Cells. / 2020 / PubMed / Full text
• The effect of interleukin 6 deficiency on myocardial signal transduction pathways activation induced by bacterial lipopolysaccharide in young and old mice. / 09.2020 / PubMed / Full text
• Silibinin and SARS-CoV-2: Dual Targeting of Host Cytokine Storm and Virus Replication Machinery for Clinical Management of COVID-19 Patients. / 07.06.2020 / PubMed / Full text
• Implication of JAK1/STAT3/SOCS3 Pathway in Aging of Cerebellum of Male Rat: Histological and Molecular study. / 01.06.2020 / PubMed / Full text
• Atorvastatin-induced senescence of hepatocellular carcinoma is mediated by downregulation of hTERT through the suppression of the IL-6/STAT3 pathway. / 2020 / PubMed / Full text
• Deciphering the Molecular Mechanism of Spontaneous Senescence in Primary Epithelial Ovarian Cancer Cells. / 27.01.2020 / PubMed / Full text
• Persistent Activation of STAT3 Pathway in the Retina Induced Vision Impairment and Retinal Degenerative Changes in Ageing Mice. / 2019 / PubMed / Full text
• Interleukin-10 induces senescence of activated hepatic stellate cells via STAT3-p53 pathway to attenuate liver fibrosis. / 02.2020 / PubMed / Full text

CP

• A Life Course Perspective on Growing Older With Cerebral Palsy. / 19.11.2020 / PubMed / Full text
• The molecular anatomy and functions of the choroid plexus in healthy and diseased brain. / 01.11.2020 / PubMed / Full text
• The effects and mechanism of collagen peptide and elastin peptide on skin aging induced by D-galactose combined with ultraviolet radiation. / 09.2020 / PubMed / Full text
• Model based strategies towards protein A resin lifetime optimization and supervision. / 16.08.2020 / PubMed / Full text
• The influence of age and environmental conditions on supplement intake by beef cattle winter grazing northern mixed-grass rangelands. / 01.07.2020 / PubMed / Full text
• Cyclophosphamide, a cancer chemotherapy drug-induced early onset of reproductive senescence and alterations in reproductive performance and their prevention in mice. / 15.06.2020 / PubMed / Full text
• Asymptomatic [i]Clostridium perfringens[/i] Inhabitation in Intestine Can Cause Inflammation, Apoptosis, and Disorders in Brain. / 01.2020 / PubMed / Full text
• The Role of the Clinical Pharmacist in the Management of People Living with HIV in the Modern Antiretroviral Era. / 2019 / PubMed / Full text
• A clinically feasible method for the assessment and characterization of pain in patients with chronic pancreatitis. / 01.2020 / PubMed / Full text
• Differences in geometric strength at the contralateral hip between men with hip fracture and non-fractured comparators. / 03.2020 / PubMed / Full text
• Factors associated with the number of clinical pharmacy recommendations: findings from an observational study in geriatric inpatients. / 23.10.2019 / PubMed / Full text
• Protection against oxidative stress and anti-aging effect in Drosophila of royal jelly-collagen peptide. / 01.2020 / PubMed / Full text

APP

• Pre-symptomatic Caspase-1 inhibitor delays cognitive decline in a mouse model of Alzheimer disease and aging. / 11.09.2020 / PubMed / Full text
• Regorafenib Regulates AD Pathology, Neuroinflammation, and Dendritic Spinogenesis in Cells and a Mouse Model of AD. / 09.07.2020 / PubMed / Full text
• An agnostic reevaluation of the amyloid cascade hypothesis of Alzheimer's disease pathogenesis: The role of APP homeostasis. / 11.2020 / PubMed / Full text
• Transcriptomic profiling of microglia and astrocytes throughout aging. / 01.04.2020 / PubMed / Full text
• Platelets in Amyloidogenic Mice Are Activated and Invade the Brain. / 2020 / PubMed / Full text
• CHIP modulates APP-induced autophagy-dependent pathological symptoms in Drosophila. / 02.2020 / PubMed / Full text
• Studies on APP metabolism related to age-associated mitochondrial dysfunction in APP/PS1 transgenic mice. / 19.11.2019 / PubMed / Full text
• Intermittent Hypoxia-Hyperoxia Training Improves Cognitive Function and Decreases Circulating Biomarkers of Alzheimer's Disease in Patients with Mild Cognitive Impairment: A Pilot Study. / 30.10.2019 / PubMed / Full text
• The Implication of Androgens in the Presence of Protein Kinase C to Repair Alzheimer’s Disease-Induced Cognitive Dysfunction / 03.2020 / PubMed / Full text
• Modulation of Neural and Muscular Adaptation Processes During Resistance Training by Fish Protein Ingestions in Older Adults. / 17.04.2020 / PubMed / Full text
• Antipsychotic Polypharmacy in Older Adult Asian Patients With Schizophrenia: Research on Asian Psychotropic Prescription Pattern. / 11.2019 / PubMed / Full text
• A pleiotropic role for exosomes loaded with the amyloid β precursor protein carboxyl-terminal fragments in the brain of Down syndrome patients. / 12.2019 / PubMed / Full text

ATM

• SATMF Suppresses the Premature Senescence Phenotype of the ATM Loss-of-Function Mutant and Improves Its Fertility in [i]Arabidopsis[/i]. / 30.10.2020 / PubMed / Full text
• ATM mediated-p53 signaling pathway forms a novel axis for senescence control. / 11.2020 / PubMed / Full text
• Non-canonical ATM/MRN activities temporally define the senescence secretory program. / 05.10.2020 / PubMed / Full text
• ATM is a key driver of NF-κB-dependent DNA-damage-induced senescence, stem cell dysfunction and aging. / 22.03.2020 / PubMed / Full text
• ATM suppresses leaf senescence triggered by DNA double-strand break through epigenetic control of senescence-associated genes in Arabidopsis. / 07.2020 / PubMed / Full text
• Glioblastoma Cells Do Not Affect Axitinib-Dependent Senescence of HUVECs in a Transwell Coculture Model. / 21.02.2020 / PubMed / Full text
• Declining BRCA-Mediated DNA Repair in Sperm Aging and its Prevention by Sphingosine-1-Phosphate. / 03.2020 / PubMed / Full text
• BRCA-related ATM-mediated DNA double-strand break repair and ovarian aging. / 01.01.2020 / PubMed / Full text
• ATM Deficiency Accelerates DNA Damage, Telomere Erosion, and Premature T Cell Aging in HIV-Infected Individuals on Antiretroviral Therapy. / 2019 / PubMed / Full text
• SMG1 heterozygosity exacerbates haematopoietic cancer development in Atm null mice by increasing persistent DNA damage and oxidative stress. / 12.2019 / PubMed / Full text
• LncRNA RP11-670E13.6, interacted with hnRNPH, delays cellular senescence by sponging microRNA-663a in UVB damaged dermal fibroblasts. / 23.08.2019 / PubMed / Full text
• Tel1/ATM Signaling to the Checkpoint Contributes to Replicative Senescence in the Absence of Telomerase. / 10.2019 / PubMed / Full text

GFAP

• Immunohistological Detection of Active Satellite Cellsin Rat Dorsal Root Ganglia after Parenteral Administration of Lipopolysaccharide and during Aging. / 09.2020 / PubMed / Full text
• Transgenic Mice Expressing Human α-Synuclein in Noradrenergic Neurons Develop Locus Ceruleus Pathology and Nonmotor Features of Parkinson's Disease. / 23.09.2020 / PubMed / Full text
• ApoE Genotype-Dependent Response to Antioxidant and Exercise Interventions on Brain Function. / 25.06.2020 / PubMed / Full text
• Age-Dependent Heterogeneity of Murine Olfactory Bulb Astrocytes. / 2020 / PubMed / Full text
• Neuroinflammation in Aged Brain: Impact of the Oral Administration of Ellagic Acid Microdispersion. / 21.05.2020 / PubMed / Full text
• Long-term treatment with spermidine increases health span of middle-aged Sprague-Dawley male rats. / 06.2020 / PubMed / Full text
• Meta-analysis of human prefrontal cortex reveals activation of GFAP and decline of synaptic transmission in the aging brain. / 05.03.2020 / PubMed / Full text
• Astroglial biotin deprivation under endoplasmic reticulum stress uncouples BCAA-mTORC1 role in lipid synthesis to prolong autophagy inhibition in the aging brain. / 09.2020 / PubMed / Full text
• Long-lived mice with reduced growth hormone signaling have a constitutive upregulation of hepatic chaperone-mediated autophagy. / 12.02.2020 / PubMed / Full text
• Lipopolysaccharide exposure during late embryogenesis triggers and drives Alzheimer-like behavioral and neuropathological changes in CD-1 mice. / 03.2020 / PubMed / Full text
• Increased levels of Aβ42 decrease the lifespan of ob/ob mice with dysregulation of microglia and astrocytes. / 02.2020 / PubMed / Full text
• Selective brain neuronal and glial losses without changes in GFAP immunoreactivity: Young versus mature adult Wistar rats. / 09.2019 / PubMed / Full text

CGA

• Safety and efficacy of preoperative chemoradiotherapy in fit older patients with intermediate or locally advanced rectal cancer evaluated by comprehensive geriatric assessment: A planned interim analysis of a multicenter, phase II trial. / 04.11.2020 / PubMed / Full text
• The Protective Effect of Chlorogenic Acid on Vascular Senescence via the Nrf2/HO-1 Pathway. / 25.06.2020 / PubMed / Full text
• Association between comprehensive geriatric assessment and short-term outcomes among older adult patients with stroke: A nationwide retrospective cohort study using propensity score and instrumental variable methods. / 06.2020 / PubMed / Full text
• Interventions to Improve Clinical Outcomes in Older Adults Admitted to a Surgical Service: A Systematic Review and Meta-analysis. / 12.2020 / PubMed / Full text
• A Computerized Frailty Assessment Tool at Points-of-Care: Development of a Standalone Electronic Comprehensive Geriatric Assessment/Frailty Index (eFI-CGA). / 2020 / PubMed / Full text
• Allocating patients to geriatric medicine wards in a tertiary university hospital in England: A service evaluation of the Specialist Advice for the Frail Elderly (SAFE) team. / 09.2018 / PubMed / Full text
• Role of Frailty on Risk Stratification in Cardiac Surgery and Procedures. / 2020 / PubMed / Full text
• Developing an objective structured clinical examination in comprehensive geriatric assessment - A pilot study. / 05-08.2019 / PubMed / Full text
• How do doctors choose treatment for older gynecological cancer patients? A Japanese Gynecologic Oncology Group survey of gynecologic oncologists. / 04.2020 / PubMed / Full text
• Validation of the Pictorial Fit-Frail Scale in a memory clinic setting. / 09.2020 / PubMed / Full text
• Impact of Resolution of Hyponatremia on Neurocognitive and Motor Performance in Geriatric Patients. / 29.08.2019 / PubMed / Full text
• Health outcome of older hospitalized patients in internal medicine environments evaluated by Identification of Seniors at Risk (ISAR) screening and geriatric assessment. / 14.08.2019 / PubMed / Full text

TH

• Thyroid hormone signaling is associated with physical performance, muscle mass, and strength in a cohort of oldest-old: results from the Mugello study. / 21.11.2020 / PubMed / Full text
• Social Environment Ameliorates Behavioral and Immune Impairments in Tyrosine Hydroxylase Haploinsufficient Female Mice. / 09.08.2020 / PubMed / Full text
• Mechanism of thyroid hormone signaling in skeletal muscle of aging mice. / 27.07.2020 / PubMed / Full text
• Longitudinal changes in bone mineral density and trabecular bone score in Korean adults: a community-based prospective study. / 03.07.2020 / PubMed / Full text
• Quantitative proteomic profiling of the rat substantia nigra places glial fibrillary acidic protein at the hub of proteins dysregulated during aging: Implications for idiopathic Parkinson's disease. / 07.2020 / PubMed / Full text
• Withaferin-A Protects the Nigral Dopamine Neuron and Recovers Motor Activity in Aged Rats. / 2019 / PubMed / Full text
• Effects of physical activity on bone mineral density in older adults: Korea National Health and Nutrition Examination Survey, 2008-2011. / 26.10.2019 / PubMed / Full text
• Age-Related Resistance to Thyroid Hormone Action. / 11.2019 / PubMed / Full text
• Age-Dependent Changes in Glucose Homeostasis in Male Deiodinase Type 2 Knockout Zebrafish. / 01.11.2019 / PubMed / Full text
• Age effect on thyroid hormone brain response in male mice. / 12.2019 / PubMed / Full text
• Aging Is Associated with Low Thyroid State and Organ-Specific Sensitivity to Thyroxine. / 12.2019 / PubMed / Full text

SOD2

• Astaxanthin Counteracts Vascular Calcification In Vitro Through an Early Up-Regulation of SOD2 Based on a Transcriptomic Approach. / 12.11.2020 / PubMed / Full text
• Alginate Oligosaccharide Prevents against D-galactose-mediated Cataract in C57BL/6J Mice via Regulating Oxidative Stress and Antioxidant System. / 06.11.2020 / PubMed / Full text
• Protoflavones in melanoma therapy: Prooxidant and pro-senescence effect of protoapigenone and its synthetic alkyl derivative in A375 cells. / 01.11.2020 / PubMed / Full text
• Ginsenoside Rg1 protects against Sca-1 HSC/HPC cell aging by regulating the SIRT1-FOXO3 and SIRT3-SOD2 signaling pathways in a γ-ray irradiation-induced aging mice model. / 08.2020 / PubMed / Full text
• Almond Skin Extracts and Chlorogenic Acid Delay Chronological Aging and Enhanced Oxidative Stress Response in Yeast. / 28.05.2020 / PubMed / Full text
• Opposing p53 and mTOR/AKT promote an in vivo switch from apoptosis to senescence upon telomere shortening in zebrafish. / 19.05.2020 / PubMed / Full text
• Bioactive peptides derived from crimson snapper and in vivo anti-aging effects on fat diet-induced high fat Drosophila melanogaster. / 29.01.2020 / PubMed / Full text
• Ellagic acid prolongs the lifespan of Drosophila melanogaster. / 02.2020 / PubMed / Full text
• Chlorella vulgaris modulates the expression of senescence-associated genes in replicative senescence of human diploid fibroblasts. / 01.2020 / PubMed / Full text
• Age-Associated Changes in Antioxidants and Redox Proteins of Rat Heart. / 30.12.2019 / PubMed / Full text
• Impact of curcumin on replicative and chronological aging in the Saccharomyces cerevisiae yeast. / 02.2020 / PubMed / Full text

MB

• Probing menstrual bloodstain aging with fluorescence spectroscopy. / 13.11.2020 / PubMed / Full text
• Effect of physical exercise and medication on enhancing cognitive function in older adults with vascular risk. / 11.2020 / PubMed / Full text
• A novel indenone derivative selectively induces senescence in MDA-MB-231 (breast adenocarcinoma) cells. / 01.11.2020 / PubMed / Full text
• Improved Autophagic Flux in Escapers from Doxorubicin-Induced Senescence/Polyploidy of Breast Cancer Cells. / 24.08.2020 / PubMed / Full text
• Lifespan regulation in α/β posterior neurons of the fly mushroom bodies by Rab27. / 08.2020 / PubMed / Full text
• Tailored Functionalized Magnetic Nanoparticles to Target Breast Cancer Cells Including Cancer Stem-Like Cells. / 29.05.2020 / PubMed / Full text
• "Mitotic Slippage" and Extranuclear DNA in Cancer Chemoresistance: A Focus on Telomeres. / 16.04.2020 / PubMed / Full text
• Diversity of the Senescence Phenotype of Cancer Cells Treated with Chemotherapeutic Agents. / 23.11.2019 / PubMed / Full text
• Downregulation of the inflammatory network in senescent fibroblasts and aging tissues of the long-lived and cancer-resistant subterranean wild rodent, Spalax. / 01.2020 / PubMed / Full text
• Quantification of the health-status of the Dutch Labrador retriever population. / 01.11.2019 / PubMed / Full text
• Conjugated Physiological Resveratrol Metabolites Induce Senescence in Breast Cancer Cells: Role of p53/p21 and p16/Rb Pathways, and ABC Transporters. / 11.2019 / PubMed / Full text

PC

• Blended home-based exercise and dietary protein in community-dwelling older adults: a cluster randomized controlled trial. / 26.10.2020 / PubMed / Full text
• Right ventricular diastolic function in aging: a head-to-head comparison between phase-contrast MRI and Doppler echocardiography. / 27.09.2020 / PubMed / Full text
• Pulse Width and Implantable Pulse Generator Longevity in Pallidal Deep Brain Stimulation for Dystonia: A Population-Based Comparative Effectiveness Study. / 2020 / PubMed / Full text
• Gemcitabine plus nab-paclitaxel with initial dose reduction for older patients with advanced pancreatic cancer. / 20.06.2020 / PubMed / Full text
• Protective effects of 17-β-oestradiol and phytoestrogen on age-induced oxidative stress and inhibition of surfactant synthesis in rat type II pneumocytes. / 02.2021 / PubMed / Full text
• Pacing During 200-m Competitive Masters Swimming. / 07.2020 / PubMed / Full text
• Prostate cancer in Pennsylvania: The role of older age at diagnosis, aggressiveness, and environmental risk factors on treatment and mortality using data from the Pennsylvania Cancer Registry. / 05.2020 / PubMed / Full text
• Extracranial versus intracranial hydro-hemodynamics during aging: a PC-MRI pilot cross-sectional study. / 14.01.2020 / PubMed / Full text
• Age-specific health-related quality of life in disease-free long-term prostate cancer survivors versus male population controls-results from a population-based study. / 06.2020 / PubMed / Full text
• Cross-Linked Polyphenol-Based Drug Nano-Self-Assemblies Engineered to Blockade Prostate Cancer Senescence. / 23.10.2019 / PubMed / Full text
• An Immersive Virtual Reality Platform for Assessing Spatial Navigation Memory in Predementia Screening: Feasibility and Usability Study. / 03.09.2019 / PubMed / Full text

TLR4

• Age-Dependent Changes of Adipokine and Cytokine Secretion From Rat Adipose Tissue by Endogenous and Exogenous Toll-Like Receptor Agonists. / 2020 / PubMed / Full text
• Role of Toll Like Receptor 4 in Alzheimer's Disease. / 2020 / PubMed / Full text
• Commentary on Some Recent Theses Relevant to Combating Aging: August 2020. / 08.2020 / PubMed / Full text
• Sialylation and Galectin-3 in Microglia-Mediated Neuroinflammation and Neurodegeneration. / 2020 / PubMed / Full text
• Chemerin facilitates intervertebral disc degeneration via TLR4 and CMKLR1 and activation of NF-kB signaling pathway. / 11.06.2020 / PubMed / Full text
• Toll-like receptor 4 differentially regulates adult hippocampal neurogenesis in an age- and sex-dependent manner. / 09.2020 / PubMed / Full text
• Aging-associated immunosenescence via alterations in splenic immune cell populations in rat. / 15.01.2020 / PubMed / Full text
• Leptin induces immunosenescence in human B cells. / 02.2020 / PubMed / Full text
• Genetic Variation in the Magnitude and Longevity of the IgG Subclass Response to a Diphtheria-Tetanus-Acellular Pertussis (DTaP) Vaccine in Mice. / 20.09.2019 / PubMed / Full text
• Rapamycin improves sevoflurane‑induced cognitive dysfunction in aged rats by mediating autophagy through the TLR4/MyD88/NF‑κB signaling pathway. / 10.2019 / PubMed / Full text

FEV

• Prediction of Lung Function in Adolescence Using Epigenetic Aging: A Machine Learning Approach. / 09.11.2020 / PubMed / Full text
• Effect of Age on the Efficacy and Safety of Once-Daily Single-Inhaler Triple Therapy Fluticasone Furoate/Umeclidinium/Vilanterol in Patients With Chronic Obstructive Pulmonary Disease: A Post Hoc Analysis of the IMPACT Trial. / 05.10.2020 / PubMed / Full text
• A comprehensive analysis of factors related to lung function in older adults: Cross-sectional findings from the Canadian Longitudinal Study on Aging. / 11.2020 / PubMed / Full text
• Risk factors associated with the detection of pulmonary emphysema in older asymptomatic respiratory subjects. / 09.06.2020 / PubMed / Full text
• Tiotropium Respimat Efficacy and Safety in Asthma: Relationship to Age. / 09.2020 / PubMed / Full text
• Current Bronchodilator Responsiveness Criteria Underestimate Asthma in Older Adults. / 08.2020 / PubMed / Full text
• Physical performances show conflicting associations in aged manual workers. / 10.02.2020 / PubMed / Full text
• FEV as a Standalone Spirometric Predictor and the Attributable Fraction for Death in Older Persons. / 02.2020 / PubMed / Full text
• An Individualized Prediction Model for Long-term Lung Function Trajectory and Risk of COPD in the General Population. / 03.2020 / PubMed / Full text
• Telomere length and lung function in a population-based cohort of children and mid-life adults. / 12.2019 / PubMed / Full text

LPA

• Ginseng gintonin, aging societies, and geriatric brain diseases. / 03.2021 / PubMed / Full text
• Late-life related subtypes of depression - a data-driven approach on cognitive domains and physical frailty. / 22.05.2020 / PubMed / Full text
• Does sedentary time increase in older adults in the days following participation in intense exercise? / 12.2020 / PubMed / Full text
• Association of Long-term Exposure to Elevated Lipoprotein(a) Levels With Parental Life Span, Chronic Disease-Free Survival, and Mortality Risk: A Mendelian Randomization Analysis. / 05.02.2020 / PubMed / Full text
• Elevated Autotaxin and LPA Levels During Chronic Viral Hepatitis and Hepatocellular Carcinoma Associate with Systemic Immune Activation. / 25.11.2019 / PubMed / Full text
• Lysophosphatidic acid receptor LPA prevents oxidative stress and cellular senescence in Hutchinson-Gilford progeria syndrome. / 01.2020 / PubMed / Full text
• Associations of Sedentary and Physically-Active Behaviors With Cognitive-Function Decline in Community-Dwelling Older Adults: Compositional Data Analysis From the NEIGE Study. / 05.11.2020 / PubMed / Full text
• Validation and comparison of two automated methods for quantifying brain white matter hyperintensities of presumed vascular origin. / 02.2020 / PubMed / Full text
• The Sedentary Time and Physical Activity Levels on Physical Fitness in the Elderly: A Comparative Cross Sectional Study. / 01.10.2019 / PubMed / Full text
• Light-Intensity Physical Activity in a Large Prospective Cohort of Older US Adults: A 21-Year Follow-Up of Mortality. / 2020 / PubMed / Full text

SIRT6

• Association between SIRT6 Methylation and Human Longevity in a Chinese Population. / 25.11.2020 / PubMed / Full text
• The SIRT6 activator MDL-800 improves genomic stability and pluripotency of old murine-derived iPS cells. / 08.2020 / PubMed / Full text
• Sirtuins as Possible Predictors of Aging and Alzheimer's Disease Development: Verification in the Hippocampus and Saliva. / 10.2020 / PubMed / Full text
• Age-related epigenetic drift deregulates [i]SIRT6[/i] expression and affects its downstream genes in human peripheral blood mononuclear cells. / 12.2020 / PubMed / Full text
• Biological and catalytic functions of sirtuin 6 as targets for small-molecule modulators. / 07.08.2020 / PubMed / Full text
• Age-dependent role of SIRT6 in jawbone via regulating senescence and autophagy of bone marrow stromal cells. / 02.2020 / PubMed / Full text
• Mechanism of activation for the sirtuin 6 protein deacylase. / 31.01.2020 / PubMed / Full text
• Proteomics of Long-Lived Mammals. / 03.2020 / PubMed / Full text
• Sirtuins and SIRT6 in Carcinogenesis and in Diet. / 07.10.2019 / PubMed / Full text
• SIRT6-mediated transcriptional suppression of MALAT1 is a key mechanism for endothelial to mesenchymal transition. / 15.11.2019 / PubMed / Full text

AMH

• Beyond premature ovarian insufficiency: Staging reproductive aging in adolescent and young adult cancer survivors. / 03.11.2020 / PubMed / Full text
• Correlates and Timing of Reproductive Aging Transitions in a Global Cohort of Midlife Women With Human Immunodeficiency Virus: Insights From the REPRIEVE Trial. / 09.07.2020 / PubMed / Full text
• Epigenetic clock measuring age acceleration via DNA methylation levels in blood is associated with decreased oocyte yield. / 05.2020 / PubMed / Full text
• Modeling Variation in the Reproductive Lifespan of Female Adolescent and Young Adult Cancer Survivors Using AMH. / 01.08.2020 / PubMed / Full text
• Improving Prediction of Age at Menopause Using Multiple Anti-Müllerian Hormone Measurements: the Tehran Lipid-Glucose Study. / 01.05.2020 / PubMed / Full text
• Antimullerian Hormone and Impending Menopause in Late Reproductive Age: The Study of Women's Health Across the Nation. / 01.04.2020 / PubMed / Full text
• Basal characterization and in vitro differentiation of putative stem cells derived from the adult mouse ovary. / 01.2020 / PubMed / Full text
• Serum anti-Müllerian hormone concentration and follicle density throughout reproductive life and in different diseases-implications in fertility preservation. / 01.12.2019 / PubMed / Full text
• Associations Between Anti-Mullerian Hormone and Cardiometabolic Health in Reproductive Age Women Are Explained by Body Mass Index. / 01.01.2020 / PubMed / Full text
• Relationships between antral follicle count, blood serum concentration of anti-Müllerian hormone and fertility in mares. / 10.2019 / PubMed / Full text

ATR

• Bloodstain age estimation through infrared spectroscopy and Chemometric models. / 11.2020 / PubMed / Full text
• Artificial Intelligence and fourier-transform infrared spectroscopy for evaluating water-mediated degradation of lubricant oils. / 01.11.2020 / PubMed / Full text
• Senescence Induction by Combined Ionizing Radiation and DNA Damage Response Inhibitors in Head and Neck Squamous Cell Carcinoma Cells. / 01.09.2020 / PubMed / Full text
• Kinetics of thermal degradation and lifetime study of poly(vinylidene fluoride) (PVDF) subjected to bioethanol fuel accelerated aging. / 07.2020 / PubMed / Full text
• Supraphysiological protection from replication stress does not extend mammalian lifespan. / 06.04.2020 / PubMed / Full text
• Assessing the Retest Reliability of Prefrontal EEG Markers of Brain Rhythm Slowing in the Eyes-Closed Resting State. / 09.2020 / PubMed / Full text
• Effects of Hydrogen Peroxide and Sodium Hypochlorite Aging on Properties and Performance of Polyethersulfone Ultrafiltration Membrane. / 18.10.2019 / PubMed / Full text
• NF-κB signaling in skin aging. / 12.2019 / PubMed / Full text
• Development of a w/o emulsion using ionic liquid strategy for transdermal delivery of anti - aging component α - lipoic acid: Mechanism of different ionic liquids on skin retention and efficacy evaluation. / 01.01.2020 / PubMed / Full text
• Effect of Nitrogen-Doped Graphene Oxide on the Aging Behavior of Nitrile-Butadiene Rubber. / 10.10.2019 / PubMed / Full text

PTEN

• Senescence Reprogramming by TIMP1 Deficiency Promotes Prostate Cancer Metastasis. / 26.10.2020 / PubMed / Full text
• Alterations in Mitochondrial Dynamic-related Genes in the Peripheral Blood of Alzheimer's Disease Patients. / 2020 / PubMed / Full text
• Human ESC-sEVs alleviate age-related bone loss by rejuvenating senescent bone marrow-derived mesenchymal stem cells. / 10.08.2020 / PubMed / Full text
• The precursor of PI(3,4,5)P alleviates aging by activating daf-18(Pten) and independent of daf-16. / 08.09.2020 / PubMed / Full text
• Quercetin alleviates kidney fibrosis by reducing renal tubular epithelial cell senescence through the SIRT1/PINK1/mitophagy axis. / 15.09.2020 / PubMed / Full text
• Downregulation of PTEN mediates bleomycin-induced premature senescence in lung cancer cells by suppressing autophagy. / 05.2020 / PubMed / Full text
• miR-155 inhibits mitophagy through suppression of BAG5, a partner protein of PINK1. / 12.03.2020 / PubMed / Full text
• Environmental Exposures and Asthma Development: Autophagy, Mitophagy, and Cellular Senescence. / 2019 / PubMed / Full text
• PTEN loss regulates alveolar epithelial cell senescence in pulmonary fibrosis depending on Akt activation. / 17.09.2019 / PubMed / Full text

CCK

• Senolytic agent Quercetin ameliorates intervertebral disc degeneration via the Nrf2/NF-κB axis. / 23.11.2020 / PubMed / Full text
• Astragalus improve aging bone marrow mesenchymal stem cells (BMSCs) vitality and osteogenesis through VD-FGF23-Klotho axis. / 2020 / PubMed / Full text
• Effects of Age on Acute Appetite-Related Responses to Whey-Protein Drinks, Including Energy Intake, Gastric Emptying, Blood Glucose, and Plasma Gut Hormone Concentrations-A Randomized Controlled Trial. / 06.04.2020 / PubMed / Full text
• Lactose induced redox-dependent senescence and activated Nrf2 pathway. / 2019 / PubMed / Full text
• Quercetin Suppresses the Progression of Atherosclerosis by Regulating MST1-Mediated Autophagy in ox-LDL-Induced RAW264.7 Macrophage Foam Cells. / 03.12.2019 / PubMed / Full text
• LncRNA AW112010 Promotes Mitochondrial Biogenesis and Hair Cell Survival: Implications for Age-Related Hearing Loss. / 2019 / PubMed / Full text
• Effects of age on feeding response: Focus on the rostral C1 neuron and its glucoregulatory proteins. / 01.2020 / PubMed / Full text
• Ser-Tyr and Asn-Ala, vasorelaxing dipeptides found by comprehensive screening, reduce blood pressure via different age-dependent mechanisms. / 04.11.2019 / PubMed / Full text
• Fisetin, via CKIP-1/REGγ, limits oxidized LDL-induced lipid accumulation and senescence in RAW264.7 macrophage-derived foam cells. / 15.12.2019 / PubMed / Full text

FGF21

• Differential effects of sulfur amino acid-restricted and low-calorie diets on gut microbiome profile and bile acid composition in male C57BL6/J mice. / 27.10.2020 / PubMed / Full text
• Relationship between physical activity and circulating fibroblast growth factor 21 in middle-aged and older adults. / 11.2020 / PubMed / Full text
• Exercise and dietary intervention ameliorate high-fat diet-induced NAFLD and liver aging by inducing lipophagy. / 09.2020 / PubMed / Full text
• Mitochondria, immunosenescence and inflammaging: a role for mitokines? / 10.2020 / PubMed / Full text
• Age-at-onset-dependent effects of sulfur amino acid restriction on markers of growth and stress in male F344 rats. / 07.2020 / PubMed / Full text
• Fibroblast growth factor 21 prolongs lifespan and improves stress tolerance in the silkworm, [i]Bombyx mori[/i]. / 03.2020 / PubMed / Full text
• Neurogenesis and prolongevity signaling in young germ-free mice transplanted with the gut microbiota of old mice. / 13.11.2019 / PubMed / Full text
• Fibroblast Growth Factor 21 Mediates the Associations between Exercise, Aging, and Glucose Regulation. / 02.2020 / PubMed / Full text
• Effects of Moderate Chronic Food Restriction on the Development of Postprandial Dyslipidemia with Ageing. / 10.08.2019 / PubMed / Full text

TG

• Inhibition of the alternative lengthening of telomeres pathway by subtelomeric sequences in Saccharomyces cerevisiae. / 12.2020 / PubMed / Full text
• E4orf1, an Adeno-viral protein, attenuates renal lipid accumulation in high fat fed mice: A novel approach to reduce a key risk factor for chronic kidney disease. / 10.2020 / PubMed / Full text
• Resistance exercise attenuates postprandial metabolic responses to a high-fat meal similarly in younger and older men. / 11.2020 / PubMed / Full text
• Aging-induced aberrant RAGE/PPARα axis promotes hepatic steatosis via dysfunctional mitochondrial β oxidation. / 10.2020 / PubMed / Full text
• Fenofibrate impairs liver function and structure more pronounced in old than young rats. / 27.08.2020 / PubMed / Full text
• Awareness of major cardiovascular risk factors and its relationship with markers of vascular aging: Data from the Brisighella Heart Study. / 09.06.2020 / PubMed / Full text
• Characterisation of the dynamic nature of lipids throughout the lifespan of genetically identical female and male Daphnia magna. / 27.03.2020 / PubMed / Full text
• Effects of laboratory biotic aging on the characteristics of biochar and its water-soluble organic products. / 15.01.2020 / PubMed / Full text
• Using Caenorhabditis elegans for Studying Trans- and Multi-Generational Effects of Toxicants. / 29.07.2019 / PubMed / Full text

CD34

• Comparing the Effect of TGF-β Receptor Inhibition on Human Perivascular Mesenchymal Stromal Cells Derived from Endometrium, Bone Marrow and Adipose Tissues. / 01.12.2020 / PubMed / Full text
• ACE2/ACE imbalance and impaired vasoreparative functions of stem/progenitor cells in aging. / 27.11.2020 / PubMed / Full text
• Innovative Mind-Body Intervention Day Easy Exercise Increases Peripheral Blood CD34 Cells in Adults. / 01-12.2020 / PubMed / Full text
• Human Thymic Involution and Aging in Humanized Mice. / 2020 / PubMed / Full text
• Coinhibition of activated p38 MAPKα and mTORC1 potentiates stemness maintenance of HSCs from SR1-expanded human cord blood CD34 cells via inhibition of senescence. / 12.2020 / PubMed / Full text
• Bulk and single-cell gene expression analyses reveal aging human choriocapillaris has pro-inflammatory phenotype. / 09.2020 / PubMed / Full text
• Mesenchymal stem cells repair bone marrow damage of aging rats and regulate autophagy and aging genes. / 08.2020 / PubMed / Full text
• Immune cell extracellular vesicles and their mitochondrial content decline with ageing. / 2020 / PubMed / Full text
• Young and elderly oral squamous cell carcinoma patients present similar angiogenic profile and predominance of M2 macrophages: Comparative immunohistochemical study. / 12.2019 / PubMed / Full text

ACE

• Elite swimmers possess shorter telomeres than recreationally active controls. / 15.10.2020 / PubMed / Full text
• Coronavirus Disease-2019 Conundrum: RAS Blockade and Geriatric-Associated Neuropsychiatric Disorders. / 2020 / PubMed / Full text
• Pregnancy Protects Hyperandrogenemic Female Rats From Postmenopausal Hypertension. / 09.2020 / PubMed / Full text
• Heart failure is associated with accelerated age related metabolic bone disease. / 05.06.2020 / PubMed / Full text
• Management of heart failure: an Italian national survey on fellows/specialists in geriatrics. / 10.2020 / PubMed / Full text
• Angiotensin-Converting Enzyme (ACE) genetic variation and longevity in Peruvian older people: a cross-sectional study. / 05.2020 / PubMed / Full text
• COVID-19 and chronological aging: senolytics and other anti-aging drugs for the treatment or prevention of corona virus infection? / 30.03.2020 / PubMed / Full text
• [i]A[/i]ngiotensin Converting Enzyme Inhibitors [i]C[/i]ombined with [i]E[/i]xercise for Hypertensive [i]S[/i]eniors (The ACES Trial): Study Protocol of a Randomized Controlled Trial. / 2019 / PubMed / Full text
• Vascular age. / Winter.2020 / PubMed

DBP

• Do baseline blood pressure and type of exercise influence level of reduction induced by training in hypertensive older adults? A meta-analysis of controlled trials. / 15.10.2020 / PubMed / Full text
• Attenuated aortic blood pressure responses to metaboreflex activation in older adults with dynapenia. / 09.2020 / PubMed / Full text
• The Effect of Blood Pressure on Cognitive Performance. An 8-Year Follow-Up of the Tromsø Study, Comprising People Aged 45-74 Years. / 2020 / PubMed / Full text
• Low Diastolic Blood Pressure and Cognitive Decline in Korean Elderly People: The Korean Longitudinal Study on Cognitive Aging and Dementia. / 01.2020 / PubMed / Full text
• Diastolic Blood Pressure Is Associated With Regional White Matter Lesion Load: The Northern Manhattan Study. / 02.2020 / PubMed / Full text
• Orthostatic Hypotension and Novel Blood Pressure Associated Gene Variants in Older Adults: Data From the TILDA Study. / 15.10.2020 / PubMed / Full text
• Blood pressure and hypertension prevalence among oldest-old in China for 16 year: based on CLHLS. / 09.09.2019 / PubMed / Full text
• The age-related blood pressure trajectories from young-old adults to centenarians: A cohort study. / 01.12.2019 / PubMed / Full text

CAT

• Training improves the handling of inhaler devices and reduces the severity of symptoms in geriatric patients suffering from chronic-obstructive pulmonary disease. / 09.10.2020 / PubMed / Full text
• 7-chloro-4-(phenylselanyl) quinoline co-treatment prevent oxidative stress in diabetic-like phenotype induced by hyperglycidic diet in Drosophila melanogaster. / 01.2021 / PubMed / Full text
• Aging influences in the blood-brain barrier permeability and cerebral oxidative stress in sepsis. / 15.10.2020 / PubMed / Full text
• 2 -Deoxy - d-glucose at chronic low dose acts as a caloric restriction mimetic through a mitohormetic induction of ROS in the brain of accelerated senescence model of rat. / 09-10.2020 / PubMed / Full text
• Ceftriaxone improves senile neurocognition damages induced by D-galactose in mice. / 03.2020 / PubMed / Full text
• Ginsenoside Rg1 protects against d-galactose induced fatty liver disease in a mouse model via FOXO1 transcriptional factor. / 01.08.2020 / PubMed / Full text
• Effects of long-term intermittent versus chronic calorie restriction on oxidative stress in a mouse cancer model. / 12.2019 / PubMed / Full text
• The Toxicity of Nonaged and Aged Coated Silver Nanoparticles to Freshwater Alga Raphidocelis subcapitata. / 11.2019 / PubMed / Full text

AFM

• Photocatalytic aging process of Nano-TiO coated polypropylene microplastics: Combining atomic force microscopy and infrared spectroscopy (AFM-IR) for nanoscale chemical characterization. / 15.02.2021 / PubMed / Full text
• Nanoscale infrared, thermal and mechanical properties of aged microplastics revealed by an atomic force microscopy coupled with infrared spectroscopy (AFM-IR) technique. / 20.11.2020 / PubMed / Full text
• Detecting zeta potential of polydimethylsiloxane (PDMS) in electrolyte solutions with atomic force microscope. / 15.10.2020 / PubMed / Full text
• Recent Applications of Advanced Atomic Force Microscopy in Polymer Science: A Review. / 17.05.2020 / PubMed / Full text
• Active fractions of mannoproteins derived from yeast cell wall stimulate innate and acquired immunity of adult and elderly dogs. / 03.2020 / PubMed / Full text
• The Effect of Waste Engine Oil and Waste Polyethylene on UV Aging Resistance of Asphalt. / 06.03.2020 / PubMed / Full text
• Mechanical properties measured by atomic force microscopy define health biomarkers in ageing C. elegans. / 25.02.2020 / PubMed / Full text
• Nanomechanical insights: Amyloid beta oligomer-induced senescent brain endothelial cells. / 01.12.2019 / PubMed / Full text

SIRT3

• SIRT3 protects endothelial cells from high glucose-induced senescence and dysfunction via the p53 pathway. / 05.11.2020 / PubMed / Full text
• Melatonin and Sirtuins in Buccal Epithelium: Potential Biomarkers of Aging and Age-Related Pathologies. / 30.10.2020 / PubMed / Full text
• [i]SIRT3[/i] Transfection of Aged Human Bone Marrow-Derived Mesenchymal Stem Cells Improves Cell Therapy-Mediated Myocardial Repair. / 28.04.2020 / PubMed / Full text
• 17β-estradiol inhibits H O -induced senescence in HUVEC cells through upregulating SIRT3 expression and promoting autophagy. / 10.2020 / PubMed / Full text
• CR6 interacting factor 1 deficiency induces premature senescence via SIRT3 inhibition in endothelial cells. / 04.2020 / PubMed / Full text
• Mitochondrial function in skeletal myofibers is controlled by a TRF2-SIRT3 axis over lifetime. / 03.2020 / PubMed / Full text
• Context-Dependent Roles for SIRT2 and SIRT3 in Tumor Development Upon Calorie Restriction or High Fat Diet. / 2019 / PubMed / Full text
• The yin and yang faces of the mitochondrial deacetylase sirtuin 3 in age-related disorders. / 01.2020 / PubMed / Full text

PINK1

• Spermidine inhibits neurodegeneration and delays aging via the PINK1-PDR1-dependent mitophagy pathway in [i]C. elegans[/i]. / 09.09.2020 / PubMed / Full text
• Female mice are resilient to age-related decline of substantia nigra dopamine neuron firing parameters. / 11.2020 / PubMed / Full text
• Attenuation of epigenetic regulator SMARCA4 and ERK-ETS signaling suppresses aging-related dopaminergic degeneration. / 09.2020 / PubMed / Full text
• SIRT1 alleviates high-magnitude compression-induced senescence in nucleus pulposus cells via PINK1-dependent mitophagy. / 18.07.2020 / PubMed / Full text
• Synergistic action of propolis with levodopa in the management of Parkinsonism in Drosophila melanogaster. / 23.09.2020 / PubMed / Full text
• Compression-induced senescence of nucleus pulposus cells by promoting mitophagy activation via the PINK1/PARKIN pathway. / 05.2020 / PubMed / Full text
• Doxorubicin-induced normal breast epithelial cellular aging and its related breast cancer growth through mitochondrial autophagy and oxidative stress mitigated by ginsenoside Rh2. / 07.2020 / PubMed / Full text
• Mitochondrial DNA heteroplasmy rises in substantial nigra of aged PINK1 KO mice. / 22.01.2020 / PubMed / Full text

AR

• Mechanisms of Androgen Receptor Agonist- and Antagonist-Mediated Cellular Senescence in Prostate Cancer. / 08.07.2020 / PubMed / Full text
• Interleukin-23 Represses the Level of Cell Senescence Induced by the Androgen Receptor Antagonists Enzalutamide and Darolutamide in Castration-Resistant Prostate Cancer Cells. / 08.2020 / PubMed / Full text
• A Landscape of Murine Long Non-Coding RNAs Reveals the Leading Transcriptome Alterations in Adipose Tissue during Aging. / 26.05.2020 / PubMed / Full text
• Senolytic compounds control a distinct fate of androgen receptor agonist- and antagonist-induced cellular senescent LNCaP prostate cancer cells. / 2020 / PubMed / Full text
• Role of gut microbiota in sex- and diet-dependent metabolic disorders that lead to early mortality of androgen receptor-deficient male mice. / 01.04.2020 / PubMed / Full text
• A jaboticaba extract prevents prostatic damage associated with aging and high-fat diet intake. / 26.02.2020 / PubMed / Full text
• Identifying blood-specific age-related DNA methylation markers on the Illumina MethylationEPIC® BeadChip. / 10.2019 / PubMed / Full text

IL6

• Basic immunology may lead to translational therapeutic rationale: SARS-CoV-2 and rheumatic diseases. / 09.2020 / PubMed / Full text
• ATM-deficient neural precursors develop senescence phenotype with disturbances in autophagy. / 09.2020 / PubMed / Full text
• The microRNA-34a-Induced Senescence-Associated Secretory Phenotype (SASP) Favors Vascular Smooth Muscle Cells Calcification. / 23.06.2020 / PubMed / Full text
• Impact of Influenza on Pneumococcal Vaccine Effectiveness during [i]Streptococcus pneumoniae[/i] Infection in Aged Murine Lung. / 11.06.2020 / PubMed / Full text
• Patterns of multi-domain cognitive aging in participants of the Long Life Family Study. / 10.2020 / PubMed / Full text
• Cholest-4,6-Dien-3-One Promote Epithelial-To-Mesenchymal Transition (EMT) in Biliary Tree Stem/Progenitor Cell Cultures In Vitro. / 15.11.2019 / PubMed / Full text
• Single xenotransplant of rat brown adipose tissue prolonged the ovarian lifespan of aging mice by improving follicle survival. / 12.2019 / PubMed / Full text

NHS

• Telomerase Activation to Reverse Immunosenescence in Elderly Patients With Acute Coronary Syndrome: Protocol for a Randomized Pilot Trial. / 23.09.2020 / PubMed / Full text
• Factors associated with COVID-19-related death using OpenSAFELY. / 08.2020 / PubMed / Full text
• Advanced ophthalmic nurse practitioners: the potential to improve outcomes for older people with cataracts. / 17.06.2020 / PubMed / Full text
• Patient Satisfaction in the Spanish National Health Service: Partial Least Squares Structural Equation Modeling. / 04.12.2019 / PubMed / Full text
• Heart failure with preserved ejection fraction (HFpEF) pathophysiology study (IDENTIFY-HF): does increased arterial stiffness associate with HFpEF, in addition to ageing and vascular effects of comorbidities? Rationale and design. / 19.11.2019 / PubMed / Full text
• Challenges to concordance: theories that explain variations in patient responses. / 02.10.2019 / PubMed / Full text
• Optimism is associated with exceptional longevity in 2 epidemiologic cohorts of men and women. / 10.09.2019 / PubMed / Full text

CAD

• Serum soluble Klotho is inversely related to coronary artery calcification assessed by intravascular ultrasound in patients with stable coronary artery disease. / 07.12.2020 / PubMed / Full text
• Shear bond strengths of aged and non-aged CAD/CAM materials after different surface treatments. / 10.2020 / PubMed / Full text
• Prediction of Early Postoperative Major Cardiac Events and In-Hospital Mortality in Elderly Hip Fracture Patients: The Role of Different Types of Preoperative Cardiac Abnormalities on Echocardiography Report. / 2020 / PubMed / Full text
• [Polymorbidity in elderly patients needing myocardial revascularization (a review article).] / 2019 / PubMed
• Fracture force of CAD/CAM resin composite crowns after in vitro aging. / 07.2020 / PubMed / Full text
• Clinical performance of chairside monolithic lithium disilicate glass-ceramic CAD-CAM crowns. / 11.2019 / PubMed / Full text
• Acute resveratrol supplementation in coronary artery disease: towards patient stratification. / 02.2020 / PubMed / Full text

SI

• Microarray Profiling Reveals Distinct Circulating miRNAs in Aged Male and Female Mice Subjected to Post-stroke Social Isolation. / 19.10.2020 / PubMed / Full text
• Is Heart Rate a Confounding Factor for Photoplethysmography Markers? A Systematic Review. / 10.04.2020 / PubMed / Full text
• Survival time after marked reduction in oral intake in terminally ill noncancer patients: A retrospective study. / 03.2020 / PubMed / Full text
• Adherence to Mediterranean diet moderates the association between multimorbidity and depressive symptoms in older adults. / 05-06.2020 / PubMed / Full text
• Loneliness, Social Isolation, and Objectively Measured Physical Activity in Rural-Living Older Adults. / 19.12.2019 / PubMed / Full text
• The associations between social support and negative social interaction with suicidal ideation in US Chinese older adults. / 25.10.2019 / PubMed / Full text
• Cell Senescence and Cerebral Small Vessel Disease in the Brains of People Aged 80 Years and Older. / 01.11.2019 / PubMed / Full text

TF

• A preliminary investigation of the contribution of different tenderness factors to beef loin, tri-tip and heel tenderness. / 12.2020 / PubMed / Full text
• The transcription factor ZmNAC126 accelerates leaf senescence downstream of the ethylene signalling pathway in maize. / 09.2020 / PubMed / Full text
• Extensive transcriptome changes during seasonal leaf senescence in field-grown black cottonwood (Populus trichocarpa Nisqually-1). / 20.04.2020 / PubMed / Full text
• Expression of Transferrin and Albumin in the Sperm-Storage Tubules of Japanese Quail and their Possible Involvement in Long-Term Sperm Storage. / 25.01.2020 / PubMed / Full text
• OsWRKY5 Promotes Rice Leaf Senescence via Senescence-Associated NAC and Abscisic Acid Biosynthesis Pathway. / 09.09.2019 / PubMed / Full text
• BrTCP7 Transcription Factor Is Associated with MeJA-Promoted Leaf Senescence by Activating the Expression of [i]BrOPR3[/i] and [i]BrRCCR[/i]. / 14.08.2019 / PubMed / Full text
• Activation of the Transcription of [i]BrGA20ox3[/i] by a BrTCP21 Transcription Factor Is Associated with Gibberellin-Delayed Leaf Senescence in Chinese Flowering Cabbage during Storage. / 08.08.2019 / PubMed / Full text

GDF11

• Growth differentiation factor-11 supplementation improves survival and promotes recovery after ischemic stroke in aged mice. / 04.05.2020 / PubMed / Full text
• Anti-Aging Effects of GDF11 on Skin. / 09.04.2020 / PubMed / Full text
• Targeted Approach to Distinguish and Determine Absolute Levels of GDF8 and GDF11 in Mouse Serum. / 06.2020 / PubMed / Full text
• Growth differentiation factor 11 impairs titanium implant healing in the femur and leads to mandibular bone loss. / 09.2020 / PubMed / Full text
• Systemic GDF11 stimulates the secretion of adiponectin and induces a calorie restriction-like phenotype in aged mice. / 01.2020 / PubMed / Full text
• Circulating factors in young blood as potential therapeutic agents for age-related neurodegenerative and neurovascular diseases. / 11.2019 / PubMed / Full text
• Effects of Exercise Training on Growth and Differentiation Factor 11 Expression in Aged Mice. / 2019 / PubMed / Full text

SDS

• Semiautomatic morphometric analysis of skeletal muscle obtained by needle biopsy in older adults. / 12.2020 / PubMed / Full text
• Effects of late-onset dietary intake of salidroside on insulin/insulin-like growth factor-1 (IGF-1) signaling pathway of the annual fish Nothobranchius guentheri. / 17.08.2020 / PubMed / Full text
• Quantification of Insoluble Protein Aggregation in Caenorhabditis elegans during Aging with a Novel Data-Independent Acquisition Workflow. / 07.08.2020 / PubMed / Full text
• Skeletal Muscle Myofibrillar Protein Abundance Is Higher in Resistance-Trained Men, and Aging in the Absence of Training May Have an Opposite Effect. / 10.01.2020 / PubMed / Full text
• Characterization, evaluation of nutritional parameters of Radix isatidis protein and its antioxidant activity in D-galactose induced ageing mice. / 06.11.2019 / PubMed / Full text
• [Effects of silver nanoparticles on pupation, eclosion, life span, apoptosis and protein expression in Drosophila melanogaster]. / 10.2019 / PubMed / Full text
• Does an Age-Specific Treatment Program Augment the Efficacy of a Cognitive-Behavioral Weight Loss Program in Adolescence and Young Adulthood? Results from a Controlled Study. / 02.09.2019 / PubMed / Full text

DDT

• Prognostic Value of a Test of Central Auditory Function in Conversion from Mild Cognitive Impairment to Dementia. / 2020 / PubMed / Full text
• Uptake kinetics of four hydrophobic organic pollutants in the earthworm Eisenia andrei in aged laboratory-contaminated natural soils. / 01.04.2020 / PubMed / Full text
• Adult exposure to insecticides causes persistent behavioral and neurochemical alterations in zebrafish. / 03-04.2020 / PubMed / Full text
• Second generation effects of larval metal pollutant exposure on reproduction, longevity and insecticide tolerance in the major malaria vector Anopheles arabiensis (Diptera: Culicidae). / 07.01.2020 / PubMed / Full text
• Protective effect of Pedro-Ximénez must against p,p'-DDE-induced liver damages in aged Mus spretus mice. / 02.2020 / PubMed / Full text
• Low-dose endosulfan inhibits proliferation and induces senescence and pro-inflammatory cytokine production in human lymphocytes, preferentially impacting cytotoxic cells. / 12.2019 / PubMed / Full text

GDF15

• Disease-specific plasma levels of mitokines FGF21, GDF15, and Humanin in type II diabetes and Alzheimer's disease in comparison with healthy aging. / 31.10.2020 / PubMed / Full text
• Growth differentiation factor 15 protects against the aging-mediated systemic inflammatory response in humans and mice. / 08.2020 / PubMed / Full text
• Analysis of Epigenetic Age Predictors in Pain-Related Conditions. / 2020 / PubMed / Full text
• GDF15 Plasma Level Is Inversely Associated With Level of Physical Activity and Correlates With Markers of Inflammation and Muscle Weakness. / 2020 / PubMed / Full text
• GDF15 is an epithelial-derived biomarker of idiopathic pulmonary fibrosis. / 01.10.2019 / PubMed / Full text
• Senescence-associated tissue microenvironment promotes colon cancer formation through the secretory factor GDF15. / 12.2019 / PubMed / Full text

CD44

• Hyaluronan goes to great length. / 17.07.2020 / PubMed / Full text
• Naked mole-rat very-high-molecular-mass hyaluronan exhibits superior cytoprotective properties. / 12.05.2020 / PubMed / Full text
• Maturity-dependent cartilage cell plasticity and sensitivity to external perturbation. / 06.2020 / PubMed / Full text
• Aged Mice Exhibit Severe Exacerbations of Dry Eye Disease with an Amplified Memory Th17 Cell Response. / 07.2020 / PubMed / Full text
• Chronic circadian misalignment accelerates immune senescence and abbreviates lifespan in mice. / 13.02.2020 / PubMed / Full text
• Defective induction of the proteasome associated with T-cell receptor signaling underlies T-cell senescence. / 12.2019 / PubMed / Full text

APC

• Differences between blacks and whites in well-being, beliefs, emotional states, behaviors and survival, 1978-2014. / 2020 / PubMed / Full text
• Wnt-induced, TRP53-mediated Cell Cycle Arrest of Precursors Underlies Interstitial Cell of Cajal Depletion During Aging. / 07.08.2020 / PubMed / Full text
• Burden of musculoskeletal disorders in Iran during 1990-2017: estimates from the Global Burden of Disease Study 2017. / 10.07.2020 / PubMed / Full text
• Fall-related mortality trends in older Japanese adults aged ≥65 years: a nationwide observational study. / 11.12.2019 / PubMed / Full text
• Stroke Mortality Rates and Trends in Romania, 1994-2017. / 12.2019 / PubMed / Full text
• A new approach to quantifying the EEG during walking: Initial evidence of gait related potentials and their changes with aging and dual tasking. / 15.10.2019 / PubMed / Full text

CCR2

• Hip Fracture Leads to Transitory Immune Imprint in Older Patients. / 2020 / PubMed / Full text
• The CC-chemokine receptor 2 is involved in the control of ovarian folliculogenesis and fertility lifespan in mice. / 09.2020 / PubMed / Full text
• Deficit of resolution receptor magnifies inflammatory leukocyte directed cardiorenal and endothelial dysfunction with signs of cardiomyopathy of obesity. / 08.2020 / PubMed / Full text
• Tet2-mediated clonal hematopoiesis in nonconditioned mice accelerates age-associated cardiac dysfunction. / 26.03.2020 / PubMed / Full text
• Inflammation and Ectopic Fat Deposition in the Aging Murine Liver Is Influenced by CCR2. / 02.2020 / PubMed / Full text
• Klotho-mediated targeting of CCL2 suppresses the induction of colorectal cancer progression by stromal cell senescent microenvironments. / 11.2019 / PubMed / Full text

PCNA

• Impairment of Pol β-related DNA Base-excision Repair Leads to Ovarian Aging in Mice. / 20.11.2020 / PubMed / Full text
• [Heat shock protein 90 (HSP90) in age-dependent changes in the number of fibroblasts in human skin.] / 2020 / PubMed
• A Higher Frequency Administration of the Nontoxic Cycloartane-Type Triterpene Argentatin A Improved Its Anti-Tumor Activity. / 14.04.2020 / PubMed / Full text
• [Mechanosensitive protein of Hippo regulatory pathway - transcription coactivator with PZD-binding motif (TAZ) in human skin during aging.] / 2019 / PubMed
• [Mechanosensitive Yes-associated protein in human skin during aging.] / 2019 / PubMed
• [Role of mechanosensitive protein Piezo1 in human age-dependent changes in the number of fibroblasts and blood vessels in human skin.] / 2019 / PubMed

EGF

• Acute, exercise-induced alterations in cytokines and chemokines in the blood distinguish physically active and sedentary aging. / 08.12.2020 / PubMed / Full text
• Proinflammation, profibrosis, and arterial aging. / 09.2020 / PubMed / Full text
• Hinokitiol induces cell death and inhibits epidermal growth factor-induced cell migration and signaling pathways in human cervical adenocarcinoma. / 09.2020 / PubMed / Full text
• Activation of epidermal growth factor receptor signaling mediates cellular senescence induced by certain pro-inflammatory cytokines. / 05.2020 / PubMed / Full text
• Insulin Signaling in Intestinal Stem and Progenitor Cells as an Important Determinant of Physiological and Metabolic Traits in [i]Drosophila[/i]. / 26.03.2020 / PubMed / Full text
• Different cellular properties and loss of nuclear signalling of porcine epidermal growth factor receptor with aging. / 01.05.2020 / PubMed / Full text

FOXO3

• The DNA methylation of FOXO3 and TP53 as a blood biomarker of late-onset asthma. / 09.12.2020 / PubMed / Full text
• FOXO3 targets are reprogrammed as Huntington's disease neural cells and striatal neurons face senescence with p16 increase. / 11.2020 / PubMed / Full text
• Astaxanthin as a Putative Geroprotector: Molecular Basis and Focus on Brain Aging. / 05.07.2020 / PubMed / Full text
• Inflamma-miR-21 Negatively Regulates Myogenesis during Ageing. / 23.04.2020 / PubMed / Full text
• Variable DNA methylation of aging-related genes is associated with male COPD. / 04.11.2019 / PubMed / Full text
• A conserved role of the insulin-like signaling pathway in diet-dependent uric acid pathologies in Drosophila melanogaster. / 08.2019 / PubMed / Full text

ABR

• [Hidden hearing loss and early identification]. / 07.2020 / PubMed / Full text
• Aging But Not Age-Related Hearing Loss Dominates the Decrease of Parvalbumin Immunoreactivity in the Primary Auditory Cortex of Mice. / 05-06.2020 / PubMed / Full text
• Hearing loss through apoptosis of the spiral ganglion neurons in apolipoprotein E knockout mice fed with a western diet. / 12.03.2020 / PubMed / Full text
• Effects of enriched endogenous omega-3 fatty acids on age-related hearing loss in mice. / 26.11.2019 / PubMed / Full text
• Hearing impairment and associated morphological changes in pituitary adenylate cyclase activating polypeptide (PACAP)-deficient mice. / 10.10.2019 / PubMed / Full text
• Global nurse/midwife workforce and reproductive health through social ecology lens. / 09.2019 / PubMed / Full text

NGF

• Dietary fish hydrolysate supplementation containing n-3 LC-PUFAs and peptides prevents short-term memory and stress response deficits in aged mice. / 23.09.2020 / PubMed / Full text
• Imbalance of nerve growth factor metabolism in aging women with overactive bladder syndrome. / 01.09.2020 / PubMed / Full text
• Parity Attenuates Intraepithelial Corneal Sensory Nerve Loss in Female Mice. / 21.07.2020 / PubMed / Full text
• Cholinergic System and NGF Receptors: Insights from the Brain of the Short-Lived Fish [i]Nothobranchius furzeri[/i]. / 20.06.2020 / PubMed / Full text
• Retrograde axonal transport of BDNF and proNGF diminishes with age in basal forebrain cholinergic neurons. / 12.2019 / PubMed / Full text
• C-SH2 point mutation converts p85β regulatory subunit of phosphoinositide 3-kinase to an anti-aging gene. / 03.09.2019 / PubMed / Full text

CD38

• Re-equilibration of imbalanced NAD metabolism ameliorates the impact of telomere dysfunction. / 02.11.2020 / PubMed / Full text
• TNFRSF12A and CD38 Contribute to a Vicious Circle for Chronic Obstructive Pulmonary Disease by Engaging Senescence Pathways. / 2020 / PubMed / Full text
• Aging alters acetylation status in skeletal and cardiac muscles. / 06.2020 / PubMed / Full text
• CD38 in Neurodegeneration and Neuroinflammation. / 18.02.2020 / PubMed / Full text
• CD38, a Receptor with Multifunctional Activities: From Modulatory Functions on Regulatory Cell Subsets and Extracellular Vesicles, to a Target for Therapeutic Strategies. / 27.11.2019 / PubMed / Full text
• CD38 Deficiency Alleviates D-Galactose-Induced Myocardial Cell Senescence Through NAD /Sirt1 Signaling Pathway. / 2019 / PubMed / Full text

LMNA

• Metformin alters peripheral blood mononuclear cells (PBMC) senescence biomarkers gene expression in type 2 diabetic patients. / 01.2021 / PubMed / Full text
• Protein structural and mechanistic basis of progeroid laminopathies. / 16.08.2020 / PubMed / Full text
• Progerin Expression Induces Inflammation, Oxidative Stress and Senescence in Human Coronary Endothelial Cells. / 12.05.2020 / PubMed / Full text
• The JAK1/2 inhibitor ruxolitinib delays premature aging phenotypes. / 04.2020 / PubMed / Full text
• Pharmacotherapy to gene editing: potential therapeutic approaches for Hutchinson-Gilford progeria syndrome. / 04.2020 / PubMed / Full text
• Long term breeding of the Lmna G609G progeric mouse: Characterization of homozygous and heterozygous models. / 02.2020 / PubMed / Full text

IVD

• MicroRNAs in Intervertebral Disc Degeneration, Apoptosis, Inflammation, and Mechanobiology. / 20.05.2020 / PubMed / Full text
• A step-by-step protocol for isolation of murine nucleus pulposus cells. / 12.2019 / PubMed / Full text
• Caspase-3 knockout inhibits intervertebral disc degeneration related to injury but accelerates degeneration related to aging. / 18.12.2019 / PubMed / Full text
• Finite element and deformation analyses predict pattern of bone failure in loaded zebrafish spines. / 29.11.2019 / PubMed / Full text
• Improvement in determining the risk of damage to the human lumbar functional spinal unit considering age, height, weight and sex using a combination of FEM and RSM. / 02.2020 / PubMed / Full text
• In vivo contrast-enhanced microCT for the monitoring of mouse thoracic, lumbar, and coccygeal intervertebral discs. / 06.2019 / PubMed / Full text

H2AX

• Evaluation of GammaH2AX in Buccal Cells as a Molecular Biomarker of DNA Damage in Alzheimer's Disease in the AIBL Study of Ageing. / 06.08.2020 / PubMed / Full text
• Cisplatin-induced peripheral neuropathy is associated to neuronal senescence-like response. / 29.06.2020 / PubMed / Full text
• Guanine Deaminase Stimulates Ultraviolet-induced Keratinocyte Senescence in Seborrhoeic Keratosis via Guanine Metabolites. / 06.04.2020 / PubMed / Full text
• Do BRCA1 and BRCA2 gene mutation carriers have a reduced ovarian reserve? Protocol for a prospective observational study. / 25.11.2019 / PubMed / Full text
• Slower rates of accumulation of DNA damage in leukocytes correlate with longer lifespans across several species of birds and mammals. / 15.11.2019 / PubMed / Full text
• Phosphoproteomic analysis reveals plant DNA damage signalling pathways with a functional role for histone H2AX phosphorylation in plant growth under genotoxic stress. / 12.2019 / PubMed / Full text

MAPT

• Association of relative brain age with tobacco smoking, alcohol consumption, and genetic variants. / 30.01.2020 / PubMed / Full text
• A blood-based nutritional risk index explains cognitive enhancement and decline in the multidomain Alzheimer prevention trial. / 2019 / PubMed / Full text
• Longitudinal associations of physical activity levels with morphological and functional changes related with aging: The MAPT study. / 12.2019 / PubMed / Full text
• Ageing and amyloidosis underlie the molecular and pathological alterations of tau in a mouse model of familial Alzheimer's disease. / 31.10.2019 / PubMed / Full text
• Revisiting the intersection of amyloid, pathologically modified tau and iron in Alzheimer's disease from a ferroptosis perspective. / 01.2020 / PubMed / Full text

WRN

• The Impact of Vitamin C on Different System Models of Werner Syndrome. / 17.11.2020 / PubMed / Full text
• WRN modulates translation by influencing nuclear mRNA export in HeLa cancer cells. / 14.10.2020 / PubMed / Full text
• MIB1-mediated degradation of WRN promotes cellular senescence in response to camptothecin treatment. / 09.2020 / PubMed / Full text
• A Case Report of Werner's Syndrome With a Novel Mutation From India. / 08.05.2020 / PubMed / Full text
• Evidence for premature aging in a Drosophila model of Werner syndrome. / 11.2019 / PubMed / Full text

TFEB

• A Novel Lipofuscin-detecting Marker of Senescence Relates With Hypoxia, Dysregulated Autophagy and With Poor Prognosis in Non-small-cell-lung Cancer. / 11-12.2020 / PubMed / Full text
• ESC-sEVs Rejuvenate Senescent Hippocampal NSCs by Activating Lysosomes to Improve Cognitive Dysfunction in Vascular Dementia. / 05.2020 / PubMed / Full text
• Nitrative Stress-Related Autophagic Insufficiency Participates in Hyperhomocysteinemia-Induced Renal Aging. / 2020 / PubMed / Full text
• Polyamines reverse immune senescence via the translational control of autophagy. / 01.2020 / PubMed / Full text
• Polyamines Control eIF5A Hypusination, TFEB Translation, and Autophagy to Reverse B Cell Senescence. / 03.10.2019 / PubMed / Full text

LBP

• Lipopolysaccharide binding protein is associated with CVD risk in older adults. / 08.09.2020 / PubMed / Full text
• Aging-related liver degeneration is associated with increased bacterial endotoxin and lipopolysaccharide binding protein levels. / 01.04.2020 / PubMed / Full text
• Biomarkers of leaky gut are related to inflammation and reduced physical function in older adults with cardiometabolic disease and mobility limitations. / 12.2019 / PubMed / Full text
• Needle-shaped amyloid deposition in rat mammary gland: evidence of a novel amyloid fibril protein. / 03.2020 / PubMed / Full text
• Effects of Lycium barbarum Polysaccharides on Health and Aging of [i]C. elegans[/i] Depend on [i]daf-12/daf-16[/i]. / 2019 / PubMed / Full text

FES

• An outpatient Tai Chi program: Effects on veterans' functional outcomes. / 26.11.2020 / PubMed / Full text
• Gait Function in Adults Aged 50 Years and Older With Spina Bifida. / 07.11.2020 / PubMed / Full text
• A Single Question as a Screening Tool to Assess Fear of Falling in Young-Old Community-Dwelling Persons. / 09.2020 / PubMed / Full text
• Fall-related efficacy is a useful and independent index to detect fall risk in Japanese community-dwelling older people: a 1-year longitudinal study. / 29.10.2019 / PubMed / Full text
• Investigating Changes in Real-time Conscious Postural Processing by Older Adults during Different Stance Positions Using Electroencephalography Coherence. / 10-12.2019 / PubMed / Full text

CORT

• Sex differences in body composition, metabolism-related hormones, and energy homeostasis during aging in Wistar rats. / 10.2020 / PubMed / Full text
• Effects of age and social isolation on murine hippocampal biochemistry and behavior. / 10.2020 / PubMed / Full text
• Interleukin 6 reduces allopregnanolone synthesis in the brain and contributes to age-related cognitive decline in mice. / 10.2020 / PubMed / Full text
• Sex- and age-dependent differences in the hormone and drinking responses to water deprivation. / 01.03.2020 / PubMed / Full text
• Ontogeny of the adrenocortical response in an extremely altricial bird. / 12.2019 / PubMed / Full text

CCS

• Frailty Significantly Associated with a Risk for Mid-term Outcomes in Elderly Chronic Coronary Syndrome Patients: a Prospective Study. / 01.12.2020 / PubMed / Full text
• Microbleeds and Medial Temporal Atrophy Determine Cognitive Trajectories in Normal Aging: A Longitudinal PET-MRI Study. / 2020 / PubMed / Full text
• Hippocampal Volume Loss, Brain Amyloid Accumulation, and APOE Status in Cognitively Intact Elderly Subjects. / 2019 / PubMed / Full text
• Amyloid Load, Hippocampal Volume Loss, and Diffusion Tensor Imaging Changes in Early Phases of Brain Aging. / 2019 / PubMed / Full text
• Lower bone mass is associated with subclinical atherosclerosis, endothelial dysfunction and carotid thickness in the very elderly. / 01.2020 / PubMed / Full text

FGF23

• Phosphate as a Pathogen of Arteriosclerosis and Aging. / 08.10.2020 / PubMed / Full text
• Plasma Soluble αKlotho, Serum Fibroblast Growth Factor 23, and Mobility Disability in Community-Dwelling Older Adults. / 01.05.2020 / PubMed / Full text
• Protective effect of Polygonatum sibiricum Polysaccharide on D-galactose-induced aging rats model. / 10.02.2020 / PubMed / Full text
• FGF23 expression is stimulated in transgenic α-Klotho longevity mouse model. / 05.12.2019 / PubMed / Full text
• Fibroblast growth factor 23 and symmetric dimethylarginine concentrations in geriatric cats. / 11.2019 / PubMed / Full text

CFI

• Psychosocial Resources for Hedonic Balance, Life Satisfaction and Happiness in the Elderly: A Path Analysis. / 06.08.2020 / PubMed / Full text
• Validity and Reliability of the Flourishing Scale in a Sample of Older Adults in Iran. / 2020 / PubMed / Full text
• The decision about retirement: A scale to describe representations and practices of medical doctors and nurses. / 07-08.2016 / PubMed / Full text
• Family versus intimate partners: Estimating who matters more for health in a 20-year longitudinal study. / 03.2020 / PubMed / Full text
• Adapting and validating the Rosenberg Self-Esteem Scale for elderly Spanish population. / 02.2020 / PubMed / Full text

TEC

• Vestibular function and cortical and sub-cortical alterations in an aging population. / 08.2020 / PubMed / Full text
• Metabolic Flexibility and Innate Immunity in Renal Ischemia Reperfusion Injury: The Fine Balance Between Adaptive Repair and Tissue Degeneration. / 2020 / PubMed / Full text
• Postnatal Involution and Counter-Involution of the Thymus. / 2020 / PubMed / Full text
• Gender Disparity Impacts on Thymus Aging and LHRH Receptor Antagonist-Induced Thymic Reconstitution Following Chemotherapeutic Damage. / 2020 / PubMed / Full text
• Clonogenic Culture of Mouse Thymic Epithelial Cells. / 2019 / PubMed / Full text

EGFR

• Type I Collagen Aging Increases Expression and Activation of EGFR and Induces Resistance to Erlotinib in Lung Carcinoma in 3D Matrix Model. / 2020 / PubMed / Full text
• Comparative effectiveness and cost-effectiveness of three first-line EGFR-tyrosine kinase inhibitors: Analysis of real-world data in a tertiary hospital in Taiwan. / 2020 / PubMed / Full text
• An Optogenetic Method to Study Signal Transduction in Intestinal Stem Cell Homeostasis. / 01.05.2020 / PubMed / Full text
• Treatment-Induced Tumor Dormancy through YAP-Mediated Transcriptional Reprogramming of the Apoptotic Pathway. / 13.01.2020 / PubMed / Full text
• Association between EGFR mutation and ageing, history of pneumonia and gastroesophageal reflux disease among patients with advanced lung cancer. / 11.2019 / PubMed / Full text

F3

• A Comprehensive Analysis of Age and Gender Effects in European Portuguese Oral Vowels. / 05.12.2020 / PubMed / Full text
• Prenatal exposure to an environmentally relevant phthalate mixture accelerates biomarkers of reproductive aging in a multiple and transgenerational manner in female mice. / 28.10.2020 / PubMed / Full text
• Combining Frontal Transcranial Direct Current Stimulation With Walking Rehabilitation to Enhance Mobility and Executive Function: A Pilot Clinical Trial. / 18.08.2020 / PubMed / Full text
• Multigenerational exposure to TiO nanoparticles in soil stimulates stress resistance and longevity of survived C. elegans via activating insulin/IGF-like signaling. / 08.2020 / PubMed / Full text
• Co-expression network analysis identified hub genes critical to triglyceride and free fatty acid metabolism as key regulators of age-related vascular dysfunction in mice. / 12.09.2019 / PubMed / Full text

ATG7

• Age-related impairment of autophagy in cervical motor neurons. / 05.12.2020 / PubMed / Full text
• Comprehensive Bioinformatics Identifies Key microRNA Players in ATG7-Deficient Lung Fibroblasts. / 09.06.2020 / PubMed / Full text
• Regulation of autophagy by DNA G-quadruplexes. / 18.05.2020 / PubMed / Full text
• ATG7 is essential for secretion of iron from ameloblasts and normal growth of murine incisors during aging. / 10.2020 / PubMed / Full text
• Enhancing Autophagy Diminishes Aberrant Ca Homeostasis and Arrhythmogenesis in Aging Rabbit Hearts. / 2019 / PubMed / Full text

F2

• Environmental risk assessment of glufosinate-resistant soybean by pollen-mediated gene flow under field conditions in the region of the genetic origin. / 17.10.2020 / PubMed / Full text
• Gestational arsenite exposure augments hepatic tumors of C3H mice by promoting senescence in F1 and F2 offspring via different pathways. / 01.12.2020 / PubMed / Full text
• Familial Longevity is Associated with an Attenuated Thyroidal Response to Recombinant Human Thyroid Stimulating Hormone. / 01.07.2020 / PubMed / Full text
• Conclusions from a behavioral aging study on male and female F2 hybrid mice on age-related behavior, buoyancy in water-based tests, and an ethical method to assess lifespan. / 11.09.2019 / PubMed / Full text
• In utero exposure to acetaminophen and ibuprofen leads to intergenerational accelerated reproductive aging in female mice. / 2019 / PubMed / Full text

UCP1

• Muscle-dependent regulation of adipose tissue function in long-lived growth hormone-mutant mice. / 28.05.2020 / PubMed / Full text
• Lack of UCP1 stimulates fatty liver but mediates UCP1-independent action of beige fat to improve hyperlipidemia in Apoe knockout mice. / 01.07.2020 / PubMed / Full text
• Postnatal leptin surge is critical for the transient induction of the developmental beige adipocytes in mice. / 01.04.2020 / PubMed / Full text
• Age-related sex differences in the expression of important disease-linked mitochondrial proteins in mice. / 05.12.2019 / PubMed / Full text
• An anti-inflammatory phenotype in visceral adipose tissue of old lean mice, augmented by exercise. / 19.08.2019 / PubMed / Full text

CD68

• Insulin activates microglia and increases COX-2/IL-1β expression in young but not in aged hippocampus. / 15.08.2020 / PubMed / Full text
• Epigenetic modulation of macrophage polarization prevents lumbar disc degeneration. / 20.04.2020 / PubMed / Full text
• Cellular senescence in recurrent tonsillitis and tonsillar hypertrophy in children. / 06.2020 / PubMed / Full text
• Ginsenoside Rg1 supplementation clears senescence-associated β-galactosidase in exercising human skeletal muscle. / 10.2019 / PubMed / Full text
• Histopathological, immunohistochemical, and molecular studies for determination of wound age and vitality in rats. / 12.2019 / PubMed / Full text

DBI

• Quantifying cumulative anticholinergic and sedative drug load among US Medicare Beneficiaries. / 01.10.2020 / PubMed / Full text
• Drug Burden Index and Cognitive and Physical Function in Aged Care Residents: A Longitudinal Study. / 08.2020 / PubMed / Full text
• Using the Drug Burden Index to identify older adults at highest risk for medication-related falls. / 12.06.2020 / PubMed / Full text
• Impact of STEADI-Rx: A Community Pharmacy-Based Fall Prevention Intervention. / 08.2020 / PubMed / Full text

MOS

• Effect of mannan oligosaccharides on the microbiota and productivity parameters of Litopenaeus vannamei shrimp under intensive cultivation in Ecuador. / 17.02.2020 / PubMed / Full text
• Predictors of health-related quality of life among older adults living with HIV in Thailand: results from the baseline and follow-up surveys. / 23.12.2019 / PubMed / Full text
• Comparison of health-related quality of life between the Han and Yi ethnicity elderly in the Yi autonomous areas of Yunnan Province. / 25.11.2019 / PubMed / Full text
• Mannan oligosaccharide increases the growth performance, immunity and resistance capability against Vibro Parahemolyticus in juvenile abalone Haliotis discus hannai Ino. / 11.2019 / PubMed / Full text

RET

• Effects of resistance exercise training on redox homeostasis in older adults. A systematic review and meta-analysis. / 09.2020 / PubMed / Full text
• Effects of an 8-week resistance training intervention on plantar flexor muscle quality and functional capacity in older women: A randomised controlled trial. / 09.2020 / PubMed / Full text
• Resistance exercise training promotes fiber type-specific myonuclear adaptations in older adults. / 01.04.2020 / PubMed / Full text
• Low skeletal muscle capillarization limits muscle adaptation to resistance exercise training in older adults. / 11.2019 / PubMed / Full text

MET

• Self-rated health in relation to fruit and vegetable consumption and physical activity among older cancer survivors. / 26.09.2020 / PubMed / Full text
• Leisure-time physical activity volume, intensity, and duration from mid- to late-life in U.S. subpopulations by race and sex. The Atherosclerosis Risk In Communities (ARIC) Study. / 13.03.2020 / PubMed / Full text
• Repressive H3K9me2 protects lifespan against the transgenerational burden of COMPASS activity in [i]C. elegans[/i]. / 09.12.2019 / PubMed / Full text
• Influence of Anthropometrics on Step-Rate Thresholds for Moderate and Vigorous Physical Activity in Older Adults: Scientific Modeling Study. / 13.12.2018 / PubMed / Full text

SFN

• The phytoprotective agent sulforaphane prevents inflammatory degenerative diseases and age-related pathologies via Nrf2-mediated hormesis. / 04.11.2020 / PubMed / Full text
• Multi-Omic Analysis Reveals Different Effects of Sulforaphane on the Microbiome and Metabolome in Old Compared to Young Mice. / 29.09.2020 / PubMed / Full text
• Sulforaphane controls the release of paracrine factors by keratinocytes and thus mitigates particulate matter-induced premature skin aging by suppressing melanogenesis and maintaining collagen homeostasis. / 10.2020 / PubMed / Full text
• Sulforaphane Inhibits Autophagy and Induces Exosome-Mediated Paracrine Senescence via Regulating mTOR/TFE3. / 07.2020 / PubMed / Full text

MFI

• The Influence of the Accelerated Aging Conditions on the Properties of Polyolefin Geogrids Used for Landfill Slope Reinforcement. / 20.08.2020 / PubMed / Full text
• Changes in Physical Meat Traits, Protein Solubility, and the Microstructure of Different Beef Muscles during Post-Mortem Aging. / 19.06.2020 / PubMed / Full text
• Effect of a low-voltage electrical stimulation on yak meat tenderness during postmortem aging. / 01-12.2020 / PubMed / Full text
• Comparative effects of dry-aging and wet-aging on physicochemical properties and digestibility of Hanwoo beef. / 03.2020 / PubMed / Full text

CD27

• The Interplay between CD27 and CD27 B Cells Ensures the Flexibility, Stability, and Resilience of Human B Cell Memory. / 03.03.2020 / PubMed / Full text
• CMV-independent increase in CD27-CD28+ CD8+ EMRA T cells is inversely related to mortality in octogenarians. / 2020 / PubMed / Full text
• Compartmentalized cytotoxic immune response leads to distinct pathogenic roles of natural killer and senescent CD8 T cells in human cutaneous leishmaniasis. / 04.2020 / PubMed / Full text
• CD27- IgD- B cell memory subset associates with inflammation and frailty in elderly individuals but only in males. / 2019 / PubMed / Full text

TP53

• p53 inhibits the osteogenic differentiation but does not induce senescence in human dental follicle cells. / 07-08.2020 / PubMed / Full text
• Mutational spectrum and dynamics of clonal hematopoiesis in anemia of older individuals. / 02.04.2020 / PubMed / Full text
• TP53/miR-34a-associated signaling targets [i]SERPINE1[/i] expression in human pancreatic cancer. / 27.01.2020 / PubMed / Full text
• Expression of p16 in nodular fasciitis: an implication for self-limited and inflammatory nature of the lesion. / 2019 / PubMed / Full text

EZH2

• Linking gene expression and phenotypic changes in the developmental and evolutionary origins of osteosclerosis in the ribs of bowhead whales (Balaena mysticetus). / 09.2020 / PubMed / Full text
• EZH2 is involved in vulnerability to neuroinflammation and depression-like behaviors induced by chronic stress in different aged mice. / 01.07.2020 / PubMed / Full text
• A positive feedback loop between EZH2 and NOX4 regulates nucleus pulposus cell senescence in age-related intervertebral disc degeneration. / 2020 / PubMed / Full text
• Perinatal exposure to bisphenol A impacts in the mammary gland morphology of adult Mongolian gerbils. / 04.2020 / PubMed / Full text

TET2

• Non-coding and Loss-of-Function Coding Variants in TET2 are Associated with Multiple Neurodegenerative Diseases. / 07.05.2020 / PubMed / Full text
• 60 Years of clonal hematopoiesis research: From X-chromosome inactivation studies to the identification of driver mutations. / 03.2020 / PubMed / Full text
• DNA methylation instability by BRAF-mediated TET silencing and lifestyle-exposure divides colon cancer pathways. / 16.12.2019 / PubMed / Full text
• Clonal haematopoiesis: connecting ageing and inflammation in cardiovascular disease. / 03.2020 / PubMed / Full text

JAK2

• Senescence in Monocytes Facilitates Dengue Virus Infection by Increasing Infectivity. / 2020 / PubMed / Full text
• Quercetin Directly Targets JAK2 and PKCδ and Prevents UV-Induced Photoaging in Human Skin. / 23.10.2019 / PubMed / Full text
• [Red blood cell lifespan detected by endogenous carbon monoxide breath test in patients with polycythemia vera]. / 01.10.2019 / PubMed / Full text
• Roles of JAK2 in Aging, Inflammation, Hematopoiesis and Malignant Transformation. / 08.08.2019 / PubMed / Full text

CD14

• Human innate immune cell crosstalk induces melanoma cell senescence. / 30.08.2020 / PubMed / Full text
• Fusion Potential of Human Osteoclasts In Vitro Reflects Age, Menopause, and In Vivo Bone Resorption Levels of Their Donors-A Possible Involvement of DC-STAMP. / 02.09.2020 / PubMed / Full text
• Association of CD14 with incident dementia and markers of brain aging and injury. / 21.01.2020 / PubMed / Full text
• Compromised Bone Healing in Aged Rats Is Associated With Impaired M2 Macrophage Function. / 2019 / PubMed / Full text

SHBG

• Endogenous Testosterone Levels and the Risk of Incident Cardiovascular Events in Elderly Men: The MrOS Prospective Study. / 01.05.2020 / PubMed / Full text
• Associations of Endogenous Sex Hormones with Carotid Plaque Burden and Characteristics in Midlife Women. / 01.04.2020 / PubMed / Full text
• Analysis of the Relationship between the Levels of Androgens and Biochemical Bone Markers in Men Aged 60-75 Years. / 22.12.2019 / PubMed / Full text
• Testosterone and Estrone Increase From the Age of 70 Years: Findings From the Sex Hormones in Older Women Study. / 01.12.2019 / PubMed / Full text

TST

• H S Donors Reverse Age-Related Gastric Malfunction Impaired Due to Fructose-Induced Injury [i]via[/i] CBS, CSE, and TST Expression. / 2020 / PubMed / Full text
• Adaptations in mechanical muscle function, muscle morphology, and aerobic power to high-intensity endurance training combined with either traditional or power strength training in older adults: a randomized clinical trial. / 05.2020 / PubMed / Full text
• Digital phenotyping by consumer wearables identifies sleep-associated markers of cardiovascular disease risk and biological aging. / 2019 / PubMed / Full text
• Objective Sleep Duration in Older Adults: Results From The Irish Longitudinal Study on Ageing. / 01.2020 / PubMed / Full text

MIP

• Inspiratory muscle training improves cerebrovascular and postural control responses during orthostatic stress in older women. / 10.2020 / PubMed / Full text
• A novel multi-marker discovery approach identifies new serum biomarkers for Parkinson's disease in older people: an EXosomes in PArkiNson Disease (EXPAND) ancillary study. / 10.2020 / PubMed / Full text
• Sexual dimorphism of physical activity on cognitive aging: Role of immune functioning. / 08.2020 / PubMed / Full text
• Comparison of balance changes after inspiratory muscle or Otago exercise training. / 2020 / PubMed / Full text

ATF6

• Cellular proteostasis decline in human senescence. / 30.11.2020 / PubMed / Full text
• Impact of endoplasmic reticulum stress on oocyte aging mechanisms. / 01.08.2020 / PubMed / Full text
• ER stress activates immunosuppressive network: implications for aging and Alzheimer's disease. / 05.2020 / PubMed / Full text
• Towards Age-Related Anti-Inflammatory Therapy: Klotho Suppresses Activation of ER and Golgi Stress Response in Senescent Monocytes. / 21.01.2020 / PubMed / Full text

S100A9

• Cigarette smoke induction of S100A9 contributes to chronic obstructive pulmonary disease. / 23.09.2020 / PubMed / Full text
• Modulation of KDM1A with vafidemstat rescues memory deficit and behavioral alterations. / 2020 / PubMed / Full text
• Cellular senescence induced by S100A9 in mesenchymal stromal cells through NLRP3 inflammasome activation. / 14.11.2019 / PubMed / Full text
• S100A9 extends lifespan in insulin deficiency. / 07.08.2019 / PubMed / Full text

TXNIP

• Panax notoginseng saponins attenuate neuroinflammation through TXNIP-mediated NLRP3 inflammasome activation in aging rats. / 10.11.2020 / PubMed / Full text
• Redox homeostasis and cell cycle activation mediate beta-cell mass expansion in aged, diabetes-prone mice under metabolic stress conditions: Role of thioredoxin-interacting protein (TXNIP). / 07.10.2020 / PubMed / Full text
• [Effect of diabetic induced thioredoxin interacting protein (TXNIP) on islet cell senescence]. / 03.2020 / PubMed / Full text
• PRMT5-TRIM21 interaction regulates the senescence of osteosarcoma cells by targeting the TXNIP/p21 axis. / 05.02.2020 / PubMed / Full text

LBR

• Lamin B receptor: role on chromatin structure, cellular senescence and possibly aging. / 31.07.2020 / PubMed / Full text
• The impact of age beyond ploidy: outcome data from 8175 euploid single embryo transfers. / 03.2020 / PubMed / Full text
• The role of lamin B receptor in the regulation of senescence-associated secretory phenotype (SASP). / 01.05.2020 / PubMed / Full text
• Lamin B receptor plays a key role in cellular senescence induced by inhibition of the proteasome. / 11.12.2019 / PubMed / Full text

C3

• Inverse association between periumbilical fat and longevity mediated by complement C3 and cardiac structure. / 18.11.2020 / PubMed / Full text
• Complement C3 deficiency ameliorates aging related changes in the kidney. / 01.11.2020 / PubMed / Full text
• Reduced sialylation triggers homeostatic synapse and neuronal loss in middle-aged mice. / 04.2020 / PubMed / Full text
• [Comparative analysis of experimental data about the effects of various polyphenols on lifespan and aging.] / 2019 / PubMed

LRRK2

• Accelerated telomere shortening independent of LRRK2 variants in Chinese patients with Parkinson's disease. / 29.10.2020 / PubMed / Full text
• The effect of LRRK2 loss-of-function variants in humans. / 06.2020 / PubMed / Full text
• Parkinson's disease-related Leucine-rich repeat kinase 2 modulates nuclear morphology and genomic stability in striatal projection neurons during aging. / 19.02.2020 / PubMed / Full text
• Autophagy and LRRK2 in the Aging Brain. / 2019 / PubMed / Full text

HGF

• Age-related changes in the immunomodulatory effects of human dental pulp derived mesenchymal stem cells on the CD4 T cell subsets. / 19.11.2020 / PubMed / Full text
• Hepatocyte growth factor (HGF) and stem cell factor (SCF) maintained the stemness of human bone marrow mesenchymal stem cells (hBMSCs) during long-term expansion by preserving mitochondrial function via the PI3K/AKT, ERK1/2, and STAT3 signaling pathways. / 31.07.2020 / PubMed / Full text
• Phenytoin sodium-ameliorated gingival fibroblast aging is associated with autophagy. / 10.2020 / PubMed / Full text
• Impaired integrin α /β -mediated hepatocyte growth factor release by stellate cells of the aged liver. / 04.2020 / PubMed / Full text

STS

• Delayed Impairment of Postural, Physical, and Muscular Functions Following Downhill Compared to Level Walking in Older People. / 2020 / PubMed / Full text
• Autophagy displays divergent roles during intermittent amino acid starvation and toxic stress-induced senescence in cultured skeletal muscle cells. / 06.10.2020 / PubMed / Full text
• The WRKY53 transcription factor enhances stilbene synthesis and disease resistance by interacting with MYB14 and MYB15 in Chinese wild grape. / 30.05.2020 / PubMed / Full text
• On the role of ageing and musculoskeletal pain on dynamic balance in manual workers. / 02.2020 / PubMed / Full text

CDK6

• Saturated Fatty Acids Promote Hepatocytic Senecence through Regulation of miR-34a/Cyclin-Dependent Kinase 6. / 24.09.2020 / PubMed / Full text
• Hepatoprotective effects of hydroxysafflor yellow A in D-galactose-treated aging mice. / 15.08.2020 / PubMed / Full text
• Anti-cell growth and anti-cancer stem cell activity of the CDK4/6 inhibitor palbociclib in breast cancer cells. / 05.2020 / PubMed / Full text
• Compromising the constitutive p16 expression sensitizes human neuroblastoma cells to Hsp90 inhibition and promotes premature senescence. / 04.2020 / PubMed / Full text

IGF1

• Genetic differences and longevity-related phenotypes influence lifespan and lifespan variation in a sex-specific manner in mice. / 11.2020 / PubMed / Full text
• 17α-estradiol modulates IGF1 and hepatic gene expression in a sex-specific manner. / 28.08.2020 / PubMed / Full text
• Pan-mammalian analysis of molecular constraints underlying extended lifespan. / 11.02.2020 / PubMed / Full text
• 17α-Estradiol promotes ovarian aging in growth hormone receptor knockout mice, but not wild-type littermates. / 01.2020 / PubMed / Full text

ERCC1

• Chronic Sildenafil Treatment Improves Vasomotor Function in a Mouse Model of Accelerated Aging. / 30.06.2020 / PubMed / Full text
• Local endothelial DNA repair deficiency causes aging-resembling endothelial-specific dysfunction. / 17.04.2020 / PubMed / Full text
• Tissue specificity of senescent cell accumulation during physiologic and accelerated aging of mice. / 03.2020 / PubMed / Full text
• Deficiency in the DNA repair protein ERCC1 triggers a link between senescence and apoptosis in human fibroblasts and mouse skin. / 03.2020 / PubMed / Full text

FH

• Genetic Factors of Alzheimer's Disease Modulate How Diet is Associated with Long-Term Cognitive Trajectories: A UK Biobank Study. / 2020 / PubMed / Full text
• Volumetric alterations in the hippocampal subfields of subjects at increased risk of dementia. / 07.2020 / PubMed / Full text
• Macroscopic hematuria as a risk factor for hypertension in ageing people with hemophilia and a family history of hypertension. / 02.2020 / PubMed / Full text
• LDL Receptor Deficiency Does not Alter Brain Amyloid-β Levels but Causes an Exacerbation of Apoptosis. / 2020 / PubMed / Full text