Aging genes 300

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Acute, exercise-induced alterations in cytokines and chemokines in the blood distinguish physically active and sedentary aging. / 08.12.2020 / PubMed / Full text
Naringenin alleviates nonalcoholic steatohepatitis in middle-aged Apoe mice: role of SIRT1. / 18.11.2020 / PubMed / Full text
Protective role of microglial HO-1 blockade in aging: Implication of iron metabolism. / 06.11.2020 / PubMed / Full text
Anti-aging effect of DL-β-hydroxybutyrate against hepatic cellular senescence induced by D-galactose or γ-irradiation via autophagic flux stimulation in male rats. / 01-02.2021 / PubMed / Full text
Exploring the extensive crosstalk between the antagonistic cytokines- TGF-β and TNF-α in regulating cancer pathogenesis. / 03.11.2020 / PubMed / Full text
ACE2/ADAM17/TMPRSS2 Interplay May Be the Main Risk Factor for COVID-19. / 2020 / PubMed / Full text
Repeated propofol exposure-induced neuronal damage and cognitive impairment in aged rats by activation of NF-κB pathway and NLRP3 inflammasome. / 01.01.2021 / PubMed / Full text
Long non-coding RNA SNHG29 regulates cell senescence via p53/p21 signaling in spontaneous preterm birth. / 15.10.2020 / PubMed / Full text
Interleukin-1β Drives Cellular Senescence of Rat Astrocytes Induced by Oligomerized Amyloid β Peptide and Oxidative Stress. / 2020 / PubMed / Full text
Cognition Is Associated With Peripheral Immune Molecules in Healthy Older Adults: A Cross-Sectional Study. / 2020 / PubMed / Full text
Human innate immune cell crosstalk induces melanoma cell senescence. / 30.08.2020 / PubMed / Full text
Anti-aging effects of [i]Ribes meyeri[/i] anthocyanins on neural stem cells and aging mice. / 12.09.2020 / PubMed / Full text
Effects of a four week detraining period on physical, metabolic, and inflammatory profiles of elderly women who regularly participate in a program of strength training. / 2020 / PubMed / Full text
Contribution of Porphyromonas gingivalis lipopolysaccharide to experimental periodontitis in relation to aging. / 26.08.2020 / PubMed / Full text
New MoDC-Targeting TNF Fusion Proteins Enhance Cyclic Di-GMP Vaccine Adjuvanticity in Middle-Aged and Aged Mice. / 2020 / PubMed / Full text
Cognitive impairment in elderly patients with rheumatic disease and the effect of disease-modifying anti-rheumatic drugs. / 30.08.2020 / PubMed / Full text
Cotinine ameliorates memory and learning impairment in senescent mice. / 11.2020 / PubMed / Full text
Kynurenines link chronic inflammation to functional decline and physical frailty. / 20.08.2020 / PubMed / Full text
Voluntary exercise training attenuated the middle-aged maturity-induced cardiac apoptosis. / 15.10.2020 / PubMed / Full text
Preclinical Evaluation of a Food-Derived Functional Ingredient to Address Skeletal Muscle Atrophy. / 29.07.2020 / PubMed / Full text
Childhood survivors of high-risk neuroblastoma show signs of immune recovery and not immunosenescence. / 12.2020 / PubMed / Full text
FK506 induces lung lymphatic endothelial cell senescence and downregulates LYVE-1 expression, with associated decreased hyaluronan uptake. / 31.07.2020 / PubMed / Full text
Late-onset hypogonadism: Reductio ad absurdum of the cardiovascular risk-benefit of testosterone replacement therapy. / 11.2020 / PubMed / Full text
Doxorubicin generates senescent microglia that exhibit altered proteomes, higher levels of cytokine secretion, and a decreased ability to internalize amyloid β. / 15.10.2020 / PubMed / Full text
Time restricted feeding provides a viable alternative to alternate day fasting when evaluated in terms of redox homeostasis in rats. / 16.07.2020 / PubMed / Full text
Associations Between Plasma Immunomodulatory and Inflammatory Mediators With VACS Index Scores Among Older HIV-Infected Adults on Antiretroviral Therapy. / 2020 / PubMed / Full text
Chrysin Impact on Oxidative and Inflammation Damages in the Liver of Aged Male Rats. / 17.07.2020 / PubMed / Full text
Correction of immunosuppression in aged septic rats by human ghrelin and growth hormone through the vagus nerve-dependent inhibition of TGF-β production. / 16.07.2020 / PubMed / Full text
Aging aggravated liver ischemia and reperfusion injury by promoting STING-mediated NLRP3 activation in macrophages. / 08.2020 / PubMed / Full text
Epigenetics of neuroinflammation: Immune response, inflammatory response and cholinergic synaptic involvement evidenced by genome-wide DNA methylation analysis of delirious inpatients. / 10.2020 / PubMed / Full text
[i]Andrographis paniculata[/i] and Its Bioactive Diterpenoids Against Inflammation and Oxidative Stress in Keratinocytes. / 17.06.2020 / PubMed / Full text
Etanercept improves aging-induced cognitive deficits by reducing inflammation and vascular dysfunction in rats. / 01.10.2020 / PubMed / Full text
Bacterial antigen translocation and age as BMI-independent contributing factors on systemic inflammation in NAFLD patients. / 09.2020 / PubMed / Full text
Bone marrow mesenchymal stem cells improve thymus and spleen function of aging rats through affecting P21/PCNA and suppressing oxidative stress. / 19.06.2020 / PubMed / Full text
Glycolic acid adjusted to pH 4 stimulates collagen production and epidermal renewal without affecting levels of proinflammatory TNF-alpha in human skin explants. / 24.06.2020 / PubMed / Full text
A20 of nucleus pulposus cells plays a self-protection role via the nuclear factor-kappa B pathway in the inflammatory microenvironment. / 05.2020 / PubMed / Full text
Age-associated decline in neural, endocrine, and immune responses in men and women: Involvement of intracellular signaling pathways. / 15.08.2020 / PubMed / Full text
Classical and lectin complement pathways and markers of inflammation for investigation of susceptibility to infections among healthy older adults. / 2020 / PubMed / Full text
Activation of FoxO1/SIRT1/RANKL/OPG pathway may underlie the therapeutic effects of resveratrol on aging-dependent male osteoporosis. / 12.06.2020 / PubMed / Full text
The senescence-associated secretome as an indicator of age and medical risk. / 18.06.2020 / PubMed / Full text
The beneficial effect of physical exercise on inflammatory makers in older individuals. / 06.06.2020 / PubMed / Full text
Comparison of Donepezil, Memantine, Melatonin, and Liuwei Dihuang Decoction on Behavioral and Immune Endocrine Responses of Aged Senescence-Accelerated Mouse Resistant 1 Mice. / 2020 / PubMed / Full text
Exercise Partially Rejuvenates Muscle Stem Cells. / 06.2020 / PubMed / Full text
Brazilian berry extract (Myrciaria jaboticaba): A promising therapy to minimize prostatic inflammation and oxidative stress. / 08.2020 / PubMed / Full text
Potential therapeutic effects of endothelial cells trans-differentiated from Wharton's Jelly-derived mesenchymal stem cells on altered vascular functions in aged diabetic rat model. / 2020 / PubMed / Full text
[Effect of fragmented sleep on postoperative cognitive function and central neuroinflammation]. / 05.05.2020 / PubMed / Full text
CXCL9 and CXCL10 display an age-dependent profile in Chagas patients: a cohort study of aging in Bambui, Brazil. / 11.05.2020 / PubMed / Full text
Can blocking inflammation enhance immunity during aging? / 05.2020 / PubMed / Full text
[[[FAS]]- and TNF-dependent ways participation in apoptosis mechanisms in hypotalumus in physiological and pathological aging.] / 2020 / PubMed
Ultrasound-guided continuous thoracic paravertebral block alleviates postoperative delirium in elderly patients undergoing esophagectomy: A randomized controlled trial. / 04.2020 / PubMed / Full text
17β-Estradiol improves insulin signalling and insulin resistance in the aged female hearts: Role of inflammatory and anti-inflammatory cytokines. / 15.07.2020 / PubMed / Full text
Synergistic Antitumor Efficacy of Magnetohyperthermia and Poly(lactic-co-glycolic acid)-Encapsulated Selol in Ehrlich Breast Adenocarcinoma Treatment in Elderly Swiss Mice. / 01.02.2020 / PubMed / Full text
Pinitol suppresses TNF-α-induced chondrocyte senescence. / 19.03.2020 / PubMed / Full text
[Aging of skin fibroblasts: genetic and epigenetic factors.] / 2019 / PubMed
Functional and traditional training improve muscle power and reduce proinflammatory cytokines in older women: A randomized controlled trial. / 01.07.2020 / PubMed / Full text
Associations of TNF-α -308 G>A and TNF-β 252 A>G with Physical Function and BNP-Rugao Longevity and Ageing Study. / 2020 / PubMed / Full text
3D TECA hydrogel reduces cellular senescence and enhances fibroblasts migration in wound healing. / 07.2018 / PubMed / Full text
Regulatory Effect of Anwulignan on the Immune Function Through Its Antioxidation and Anti-Apoptosis in D-Galactose-Induced Aging Mice. / 2020 / PubMed / Full text
Pretreatment Frailty Is Independently Associated With Increased Risk of Infections After Immunosuppression in Patients With Inflammatory Bowel Diseases. / 06.2020 / PubMed / Full text
The Citrus Flavonoid Naringenin Protects the Myocardium from Ageing-Dependent Dysfunction: Potential Role of SIRT1. / 2020 / PubMed / Full text
Relationships of inflamm-aging with circulating nutrient levels, body composition, age, and pituitary pars intermedia dysfunction in a senior horse population. / 03.2020 / PubMed / Full text
In the Absence of a TCR Signal IL-2/IL-12/18-Stimulated γδ T Cells Demonstrate Potent Anti-Tumoral Function Through Direct Killing and Senescence Induction in Cancer Cells. / 04.01.2020 / PubMed / Full text
Aging is associated with loss of beneficial effects of estrogen on leptin responsiveness in mice fed high fat diet: Role of estrogen receptor α and cytokines. / 03.2020 / PubMed / Full text
Mitochondrial Dysfunction and Alpha-Lipoic Acid: Beneficial or Harmful in Alzheimer's Disease? / 2019 / PubMed / Full text
Design, synthesis and evaluation of diosgenin carbamate derivatives as multitarget anti-Alzheimer's disease agents. / 01.02.2020 / PubMed / Full text
Oral Administration of Okara Soybean By-Product Attenuates Cognitive Impairment in a Mouse Model of Accelerated Aging. / 03.12.2019 / PubMed / Full text
Electric vagal nerve stimulation inhibits inflammation and improves early postoperation cognitive dysfunction in aged rats. / 23.11.2019 / PubMed / Full text
Metformin decreases LPS-induced inflammatory response in rabbit annulus fibrosus stem/progenitor cells by blocking HMGB1 release. / 26.11.2019 / PubMed / Full text
Active vitamin D supplementation alleviates initiation and progression of nonalcoholic fatty liver disease by repressing the p53 pathway. / 15.01.2020 / PubMed / Full text
The effects of blueberry and strawberry serum metabolites on age-related oxidative and inflammatory signaling in vitro. / 11.12.2019 / PubMed / Full text
Arsenic induces human chondrocyte senescence and accelerates rat articular cartilage aging. / 01.2020 / PubMed / Full text
Bone Benefits of Fish Oil Supplementation Depend on its EPA and DHA Content. / 08.11.2019 / PubMed / Full text
Inflammaging phenotype in rhesus macaques is associated with a decline in epithelial barrier-protective functions and increased pro-inflammatory function in CD161-expressing cells. / 12.2019 / PubMed / Full text
Single-cell transcriptomics reveals expansion of cytotoxic CD4 T cells in supercentenarians. / 26.11.2019 / PubMed / Full text
Gut microbiota combined with metabolomics reveals the metabolic profile of the normal aging process and the anti-aging effect of FuFang Zhenshu TiaoZhi(FTZ) in mice. / 01.2020 / PubMed / Full text
Intervertebral disc ageing and degeneration: The antiapoptotic effect of oestrogen. / 01.2020 / PubMed / Full text
Bone marrow-derived mesenchymal stem cells in three-dimensional co-culture attenuate degeneration of nucleus pulposus cells. / 30.10.2019 / PubMed / Full text
MicroRNA 16-5p is upregulated in calorie-restricted mice and modulates inflammatory cytokines of macrophages. / 30.01.2020 / PubMed / Full text
NF-κB signaling in skin aging. / 12.2019 / PubMed / Full text
Aerobic exercise modulates cytokine profile and sleep quality in elderly. / 06.2019 / PubMed / Full text
Heterogeneity in old fibroblasts is linked to variability in reprogramming and wound healing. / 10.2019 / PubMed / Full text
Trehalose targets Nrf2 signal to alleviate d-galactose induced aging and improve behavioral ability. / 01.01.2020 / PubMed / Full text
Anti-Inflammatory and Anti-Aging Evaluation of Pigment-Protein Complex Extracted from [i]Chlorella Pyrenoidosa[/i]. / 16.10.2019 / PubMed / Full text
Inflammatory mediators and the risk of falls among older women with acute low back pain: data from Back Complaints in the Elders (BACE)-Brazil. / 03.2020 / PubMed / Full text
Acetylcholinesterase inhibitors targeting the cholinergic anti-inflammatory pathway: a new therapeutic perspective in aging-related disorders. / 03.10.2019 / PubMed / Full text
Study on Metabolic Trajectory of Liver Aging and the Effect of Fufang Zhenzhu Tiaozhi on Aging Mice. / 2019 / PubMed / Full text
Culture Model for Non-human Primate Choroid Plexus. / 2019 / PubMed / Full text
Systemic Tumor Necrosis Factor-Alpha Trajectories Relate to Brain Health in Typically Aging Older Adults. / 13.07.2020 / PubMed / Full text
Targeting senescence improves angiogenic potential of adipose-derived mesenchymal stem cells in patients with preeclampsia. / 14.09.2019 / PubMed / Full text
[Investigation of signal molecules in saliva: prospects of application for diagnostics of myocardial infarction and the aging rate of different age people.] / 2019 / PubMed
Suppression of gut dysbiosis by Bifidobacterium longum alleviates cognitive decline in 5XFAD transgenic and aged mice. / 14.08.2019 / PubMed / Full text
Moderate hyperoxia induces senescence in developing human lung fibroblasts. / 01.11.2019 / PubMed / Full text
Aging-related carcinoembryonic antigen-related cell adhesion molecule 1 signaling promotes vascular dysfunction. / 12.2019 / PubMed / Full text
Microglia Express Insulin-Like Growth Factor-1 in the Hippocampus of Aged APP /PS1 Transgenic Mice. / 2019 / PubMed / Full text
Age- and diet-specific effects of chronic exposure to chlorpyrifos on hormones, inflammation and gut microbiota in rats. / 09.2019 / PubMed / Full text
Knockout of longevity gene Sirt1 in zebrafish leads to oxidative injury, chronic inflammation, and reduced life span. / 2019 / PubMed / Full text
Glycation of macrophages induces expression of pro-inflammatory cytokines and reduces phagocytic efficiency. / 29.07.2019 / PubMed / Full text
Tamoxifen-induced, intestinal-specific deletion of [i]Slc5a6[/i] in adult mice leads to spontaneous inflammation: involvement of NF-κB, NLRP3, and gut microbiota. / 01.10.2019 / PubMed / Full text
Systems biology and network pharmacology of frailty reveal novel epigenetic targets and mechanisms. / 22.07.2019 / PubMed / Full text
Inflammatory markers and bone health in postmenopausal women: a cross-sectional overview. / 2019 / PubMed / Full text
TNF-α-driven inflammation and mitochondrial dysfunction define the platelet hyperreactivity of aging. / 29.08.2019 / PubMed / Full text
Plasma Cells Are Obligate Effectors of Enhanced Myelopoiesis in Aging Bone Marrow. / 20.08.2019 / PubMed / Full text
Aging-induced elevation in circulating complement C1q level is associated with arterial stiffness. / 09.2019 / PubMed / Full text
Immune Mechanisms Underlying Susceptibility to Endotoxin Shock in Aged Hosts: Implication in Age-Augmented Generalized Shwartzman Reaction. / 02.07.2019 / PubMed / Full text
Inflammation-related genes are associated with epigenetic aging in HIV. / 12.2019 / PubMed / Full text
Function, Oxidative, and Inflammatory Stress Parameters in Immune Cells as Predictive Markers of Lifespan throughout Aging. / 2019 / PubMed / Full text
The Impact of Prophylactic Lacosamide on LPS-Induced Neuroinflammation in Aged Rats. / 10.2019 / PubMed / Full text
Impaired sleep quality is associated with concurrent elevations in inflammatory markers: are post-menopausal women at greater risk? / 08.07.2019 / PubMed / Full text
Potential effects of rapeseed peptide Maillard reaction products on aging-related disorder attenuation and gut microbiota modulation in d-galactose induced aging mice. / 17.07.2019 / PubMed / Full text
Ellagic acid dose and time-dependently abrogates d-galactose-induced animal model of aging: Investigating the role of PPAR-γ. / 01.09.2019 / PubMed / Full text
Lactobacillus sp. improved microbiota and metabolite profiles of aging rats. / 08.2019 / PubMed / Full text
Local and systemic effects of aging on acute pancreatitis. / 07.2019 / PubMed / Full text
Salicin prevents TNF-α-induced cellular senescence in human umbilical vein endothelial cells (HUVECs). / 12.2019 / PubMed / Full text
Age-related dynamics of pro-inflammatory cytokines in equine bronchoalveolar lavage (BAL) fluid and peripheral blood from horses managed on pasture. / 09.2019 / PubMed / Full text
The beneficial effects of 15 units of high-intensity circuit training in women is modified by age, baseline insulin resistance and physical capacity. / 06.2019 / PubMed / Full text
The effects of vitamin-rich carbohydrate pretreatment on the surgical stress response and S-100β after splenectomy in elderly rats. / 15.05.2019 / PubMed / Full text
Stem Cell-Derived Exosomes Prevent Aging-Induced Cardiac Dysfunction through a Novel Exosome/lncRNA MALAT1/NF-[i]κ[/i]B/TNF-[i]α[/i] Signaling Pathway. / 2019 / PubMed / Full text
Endothelial PPARγ Is Crucial for Averting Age-Related Vascular Dysfunction by Stalling Oxidative Stress and ROCK. / 10.2019 / PubMed / Full text
Melatonin alleviates cognition impairment by antagonizing brain insulin resistance in aged rats fed a high-fat diet. / 09.2019 / PubMed / Full text
Age-related cytokine effects on cancer-related fatigue and quality of life in acute myeloid leukemia. / 04.2020 / PubMed / Full text
Protective effect of vildagliptin on TNF-α-induced chondrocyte senescence. / 07.2019 / PubMed / Full text
Platelet-Rich Plasma (PRP) From Older Males With Knee Osteoarthritis Depresses Chondrocyte Metabolism and Upregulates Inflammation. / 08.2019 / PubMed / Full text
Effects of sulforaphane on D-galactose-induced liver aging in rats: Role of keap-1/nrf-2 pathway. / 15.07.2019 / PubMed / Full text
Protective effects of pyrroloquinoline quinine against oxidative stress-induced cellular senescence and inflammation in human renal tubular epithelial cells via Keap1/Nrf2 signaling pathway. / 07.2019 / PubMed / Full text
Long-term every-other-day administration of DMAMCL has little effect on aging and age-associated physiological decline in mice. / 02.05.2019 / PubMed / Full text
Novel insights of elevated systemic levels of bisphenol-A (BPA) linked to poor glycemic control, accelerated cellular senescence and insulin resistance in patients with type 2 diabetes. / 08.2019 / PubMed / Full text
Resveratrol attenuates inflammation environment-induced nucleus pulposus cell senescence [i]in vitro[/i]. / 31.05.2019 / PubMed / Full text
Photobiomodulation and Coenzyme Q Treatments Attenuate Cognitive Impairment Associated With Model of Transient Global Brain Ischemia in Artificially Aged Mice. / 2019 / PubMed / Full text
Circulating factors associated with sarcopenia during ageing and after intensive lifestyle intervention. / 06.2019 / PubMed / Full text
2, 3, 4', 5-tetrahydroxystilbene-2-0-β-d Glycoside Attenuates Age- and Diet-Associated Non-Alcoholic Steatohepatitis and Atherosclerosis in LDL Receptor Knockout Mice and Its Possible Mechanisms. / 01.04.2019 / PubMed / Full text
N-acetylcysteine and alpha-lipoic acid improve antioxidant defenses and decrease oxidative stress, inflammation and serum lipid levels in ovariectomized rats via estrogen-independent mechanisms. / 05.2019 / PubMed / Full text
Neuroprotective Effect of Dioscin on the Aging Brain. / 30.03.2019 / PubMed / Full text
CSF Cytokines in Aging, Multiple Sclerosis, and Dementia. / 2019 / PubMed / Full text
Neuroprotective effects of targeting BET proteins for degradation with dBET1 in aged mice subjected to ischemic stroke. / 07.2019 / PubMed / Full text
A double-blind, randomized trial on the effect of a broad-spectrum dietary supplement on key biomarkers of cellular aging including inflammation, oxidative stress, and DNA damage in healthy adults. / 04.01.2017 / PubMed / Full text
A New Understanding of the Role of IL-1 in Age-Related Intervertebral Disc Degeneration in a Murine Model. / 08.2019 / PubMed / Full text
Methane ameliorates post-operative cognitive dysfunction by inhibiting microglia NF-κB/MAPKs pathway and promoting IL-10 expression in aged mice. / 06.2019 / PubMed / Full text
Age-dependent hepatic alterations induced by a high-fat high-fructose diet. / 05.2019 / PubMed / Full text
The senescent status of endothelial cells affects proliferation, inflammatory profile and SOX2 expression in bone marrow-derived mesenchymal stem cells. / 06.2019 / PubMed / Full text
Reduced CXCL1/GRO chemokine plasma levels are a possible biomarker of elderly depression. / 15.04.2019 / PubMed / Full text
Nontuberculous mycobacterium M. avium infection predisposes aged mice to cardiac abnormalities and inflammation. / 06.2019 / PubMed / Full text
Epigenetic Age Acceleration in Adolescence Associates With BMI, Inflammation, and Risk Score for Middle Age Cardiovascular Disease. / 01.07.2019 / PubMed / Full text
Converging Paths of Pulmonary Arterial Hypertension and Cellular Senescence. / 07.2019 / PubMed / Full text
Gender-specific association of body composition with inflammatory and adipose-related markers in healthy elderly Europeans from the NU-AGE study. / 09.2019 / PubMed / Full text
Lifelong aerobic exercise protects against inflammaging and cancer. / 2019 / PubMed / Full text
Individual and combined effects of salinity and lipopolysaccharides on the immune response of juvenile Takifugu fasciatus. / 06.2019 / PubMed / Full text
The Role of Genetic Profile in Functional Performance Adaptations to Exercise Training or Physical Activity: A Systematic Review of the Literature. / 01.08.2019 / PubMed / Full text
Impact of simulated biological aging on physicochemical and biocompatibility properties of cyclic olefin copolymers. / 04.2019 / PubMed / Full text
Protective Role of Endogenous Kallistatin in Vascular Injury and Senescence by Inhibiting Oxidative Stress and Inflammation. / 2018 / PubMed / Full text
Lifelong exercise practice and immunosenescence: Master athletes cytokine response to acute exercise. / 03.2019 / PubMed / Full text
Human T2R38 Bitter Taste Receptor Expression in Resting and Activated Lymphocytes. / 2018 / PubMed / Full text
Ameliorative effect of supercritical fluid extract of Chrysanthemum indicum Linnén against D-galactose induced brain and liver injury in senescent mice via suppression of oxidative stress, inflammation and apoptosis. / 24.04.2019 / PubMed / Full text
[Effect of saponins extracted from Panax japonicas on inhibiting myocardial fibrosis by TGF-β1/Smad3 signaling pathway in aging rats]. / 11.2018 / PubMed / Full text
Aging and Hyperglycemia Intensify Dyslipidemia-Induced Oxidative Stress and Inflammation in Rats: Assessment of Restorative Potentials of ALA and EPA DHA. / 06.2019 / PubMed / Full text
CD56bright cells respond to stimulation until very advanced age revealing increased expression of cellular protective proteins SIRT1, HSP70 and SOD2. / 2018 / PubMed / Full text
Role of Exercise in Vascular Function and Inflammatory Profile in Age-Related Obesity. / 2018 / PubMed / Full text
Establishment of a lethal aged mouse model of human respiratory syncytial virus infection. / 01.2019 / PubMed / Full text
Elevated truncated oxidized phospholipids as a factor exacerbating ALI in the aging lungs. / 03.2019 / PubMed / Full text
Effect of Myricetin on Primary Open-angle Glaucoma. / 2018 / PubMed / Full text
Chronic rhinosinusitis in elderly patients is associated with an exaggerated neutrophilic proinflammatory response to pathogenic bacteria. / 03.2019 / PubMed / Full text
Nuclear Translocation of Argonaute 2 in Cytokine-Induced Senescence. / 2018 / PubMed / Full text
Dual functions for OVAAL in initiation of RAF/MEK/ERK prosurvival signals and evasion of p27-mediated cellular senescence. / 11.12.2018 / PubMed / Full text
Association of pro-inflammatory cytokines and monocyte subtypes in older and younger patients on clinical outcomes after mechanical circulatory support device implantation. / 02.2019 / PubMed / Full text
Adipose TSHB in Humans and Serum TSH in Hypothyroid Rats Inform About Cellular Senescence. / 2018 / PubMed / Full text
Involvement of ERK1/2 activation in the gene expression of senescence-associated secretory factors in human hepatic stellate cells. / 05.2019 / PubMed / Full text
Higher levels of tumor necrosis factor β are associated with frailty in socially vulnerable community-dwelling older adults. / 06.11.2018 / PubMed / Full text
Epigenetics of Delirium and Aging: Potential Role of DNA Methylation Change on Cytokine Genes in Glia and Blood Along With Aging. / 2018 / PubMed / Full text
Polydatin suppresses nucleus pulposus cell senescence, promotes matrix homeostasis and attenuates intervertebral disc degeneration in rats. / 11.2018 / PubMed / Full text
Ellagic acid reveals promising anti-aging effects against d-galactose-induced aging on human neuroblastoma cell line, SH-SY5Y: A mechanistic study. / 12.2018 / PubMed / Full text
The Neuro-Immuno-Senescence Integrative Model (NISIM) on the Negative Association Between Parasympathetic Activity and Cellular Senescence. / 2018 / PubMed / Full text
Human umbilical cord blood plasma alleviates age-related olfactory dysfunction by attenuating peripheral TNF-α expression. / 04.2019 / PubMed / Full text
Manipulating fenestrations in young and old liver sinusoidal endothelial cells. / 01.01.2019 / PubMed / Full text
The Synergy of Aging and LPS Exposure in a Mouse Model of Parkinson's Disease. / 10.2018 / PubMed / Full text
Myeloid cell-derived tumor necrosis factor-alpha promotes sarcopenia and regulates muscle cell fusion with aging muscle fibers. / 12.2018 / PubMed / Full text
mRNA expressions of peroxisome proliferator-activated receptor gamma coactivator 1α, tumor necrosis factor-α, and interleukin-6 in paraspinal muscles of patients with lumbar kyphosis: a preliminary study. / 2018 / PubMed / Full text
Leptin stimulates the release of pro-inflammatory cytokines in hypothalamic astrocyte cultures from adult and aged rats. / 12.2018 / PubMed / Full text
Effects of 8-week kettlebell training on body composition, muscle strength, pulmonary function, and chronic low-grade inflammation in elderly women with sarcopenia. / 02.10.2018 / PubMed / Full text
Research advances in the regulation of the putative ovarian germline stem cell niche on female germline stem cells. / 04.2019 / PubMed / Full text
Efficacy and safety of biological agents in the older rheumatoid arthritis patients compared to Young: A systematic review and meta-analysis. / 04.2019 / PubMed / Full text
Leptin, hsCRP, TNF-α and IL-6 levels from normal aging to dementia: Relationship with cognitive and functional status. / 10.2018 / PubMed / Full text
Systemic Inflammation Mediates Age-Related Cognitive Deficits. / 2018 / PubMed / Full text
Featured Article: Deterioration of visual function mediated by senescence-associated endoplasmic reticulum stress in inflammatory tie2-TNF mice. / 08.2018 / PubMed / Full text
Quercetin Enhances Ligand-induced Apoptosis in Senescent Idiopathic Pulmonary Fibrosis Fibroblasts and Reduces Lung Fibrosis In Vivo. / 01.2019 / PubMed / Full text
Bioactive Peptide Improves Diet-Induced Hepatic Fat Deposition and Hepatocyte Proinflammatory Response in SAMP8 Ageing Mice. / 2018 / PubMed / Full text
Senescence and odontoblastic differentiation of dental pulp cells. / 01.2018 / PubMed / Full text
Effect of resistance training on inflammatory markers of older adults: A meta-analysis. / 01.10.2018 / PubMed / Full text
Heat-induced extracellular HSP72 release is blunted in elderly diabetic people compared with healthy middle-aged and older adults, but it is partially restored by resistance training. / 01.10.2018 / PubMed / Full text
Repeated abortion in adulthood induces cognition impairment in aged mice. / 30.07.2018 / PubMed / Full text
Cumulus cell-released tumor necrosis factor (TNF)-α promotes post-ovulatory aging of mouse oocytes. / 26.07.2018 / PubMed / Full text
Comparison of neurotoxicity of dexmedetomidine as an adjuvant in brachial plexus block in rats of different age. / 09-10.2018 / PubMed / Full text
Inflammatory cytokines and immune system modulation by aerobic versus resisted exercise training for elderly. / 03.2018 / PubMed / Full text
Age-Related Adverse Inflammatory and Metabolic Changes Begin Early in Adulthood. / 15.02.2019 / PubMed / Full text
Inhibition of programmed necrosis limits infarct size through altered mitochondrial and immune responses in the aged female rat heart. / 01.11.2018 / PubMed / Full text
Accumulation of T-helper 22 cells, interleukin-22 and myeloid-derived suppressor cells promotes gastric cancer progression in elderly patients. / 07.2018 / PubMed / Full text
Co-culturing nucleus pulposus mesenchymal stem cells with notochordal cell-rich nucleus pulposus explants attenuates tumor necrosis factor-α-induced senescence. / 26.06.2018 / PubMed / Full text
The expression of C1 inhibitor (C1INH) in macrophages is upregulated by retinal pigment epithelial cells - implication in subretinal immune privilege in the aging eye. / 13.06.2018 / PubMed / Full text
Regulation of p38 mitogen-activated kinase-mediated fetal membrane senescence by statins. / 10.2018 / PubMed / Full text
Identification of proteins potentially associated with renal aging in rats. / 14.06.2018 / PubMed / Full text
Aerobic Exercise Protects from Pseudomonas aeruginosa-Induced Pneumonia in Elderly Mice. / 2018 / PubMed / Full text
Serum Tumor Necrosis Factor-alpha associates with Myocardial Oxygen Demand and Exercise Tolerance in Postmenopausal Women. / 2018 / PubMed / Full text
Exercise related anxiety-like behaviours are mediated by TNF receptor signaling, but not depression-like behaviours. / 15.09.2018 / PubMed / Full text
Accelerated vascular aging and persistent cognitive impairment in older female breast cancer survivors. / 06.2018 / PubMed / Full text
Features of Cytokine Profile in Different Age Groups. / 2014 / PubMed / Full text
Anthocyanins Improve Hippocampus-Dependent Memory Function and Prevent Neurodegeneration via JNK/Akt/GSK3β Signaling in LPS-Treated Adult Mice. / 01.2019 / PubMed / Full text
Supplementation with eicosapentaenoic acid and docosahexaenoic acid reduces high levels of circulating proinflammatory cytokines in aging adults: A randomized, controlled study. / 05.2018 / PubMed / Full text
Effects of nutritional state, aging and high chronic intake of sucrose on brain protein synthesis in rats: modulation of it by rutin and other micronutrients. / 23.05.2018 / PubMed / Full text
Plasma zinc in institutionalized elderly individuals: Relation with immune and cardiometabolic biomarkers. / 12.2018 / PubMed / Full text
Pentoxifylline, dexamethasone and azithromycin demonstrate distinct age-dependent and synergistic inhibition of TLR- and inflammasome-mediated cytokine production in human newborn and adult blood in vitro. / 2018 / PubMed / Full text
Necroptosis increases with age and is reduced by dietary restriction. / 08.2018 / PubMed / Full text
Age-Related Changes to Human Tear Composition. / 01.04.2018 / PubMed / Full text
Inhibition of UVB-induced pro-inflammatory cytokines and MMP expression by Zanthoxylum rhetsa bark extract and its active constituent hesperidin. / 08.2018 / PubMed / Full text
Effects of Baicalein on Cortical Proinflammatory Cytokines and the Intestinal Microbiome in Senescence Accelerated Mouse Prone 8. / 18.07.2018 / PubMed / Full text
Probiotic Potential of [i]Enterococcus faecium[/i] Isolated from Chicken Cecum with Immunomodulating Activity and Promoting Longevity in [i]Caenorhabditis elegans[/i]. / 28.06.2018 / PubMed / Full text
Sex Differences in Adipose Tissue CD8 T Cells and Regulatory T Cells in Middle-Aged Mice. / 2018 / PubMed / Full text
Elderly dendritic cells respond to LPS/IFN-γ and CD40L stimulation despite incomplete maturation. / 2018 / PubMed / Full text
Inosine improves cognitive function and decreases aging-induced oxidative stress and neuroinflammation in aged female rats. / 10.2018 / PubMed / Full text
Cytokine Responses to Acute Exercise in Healthy Older Adults: The Effect of Cardiorespiratory Fitness. / 2018 / PubMed / Full text
No requirement of interlukine-1 for long-term potentiation in the anterior cingulate cortex of adult mice. / 01-12.2018 / PubMed / Full text
[Electroacupuncture Intervention Improves Physical Power of Aged Rats with Low Testosterone by Reducing Chronic Inflammatory Response of Leydig Cells]. / 25.03.2018 / PubMed / Full text
Predominant gut Lactobacillus murinus strain mediates anti-inflammaging effects in calorie-restricted mice. / 21.03.2018 / PubMed / Full text
Proximity of Cytomegalovirus-Specific CD8 T Cells to Replicative Senescence in Human Immunodeficiency Virus-Infected Individuals. / 2018 / PubMed / Full text
Xanthohumol exerts protective effects in liver alterations associated with aging. / 03.2019 / PubMed / Full text
Age-related pro-inflammatory and pro-angiogenic changes in human aqueous humor. / 2018 / PubMed / Full text
Exercise and taurine in inflammation, cognition, and peripheral markers of blood-brain barrier integrity in older women. / 07.2018 / PubMed / Full text
Normal aging induces A1-like astrocyte reactivity. / 20.02.2018 / PubMed / Full text
Human blood MAIT cell subsets defined using MR1 tetramers. / 05.2018 / PubMed / Full text
The pro-inflammatory phenotype of the human non-classical monocyte subset is attributed to senescence. / 15.02.2018 / PubMed / Full text
Nucleoside Reverse Transcriptase Inhibitors (NRTIs) Induce Pathological Pain through Wnt5a-Mediated Neuroinflammation in Aging Mice. / 06.2018 / PubMed / Full text
Aged Chinese-origin rhesus macaques infected with SIV develop marked viremia in absence of clinical disease, inflammation or cognitive impairment. / 01.02.2018 / PubMed / Full text
Protective effect of crocin against d-galactose-induced aging in mice. / 01-02.2018 / PubMed / Full text
Osteogenic protein-1 attenuates the inflammatory cytokine-induced NP cell senescence through regulating the ROS/NF-κB pathway. / 03.2018 / PubMed / Full text
Metformin regulates metabolic and nonmetabolic pathways in skeletal muscle and subcutaneous adipose tissues of older adults. / 04.2018 / PubMed / Full text
Impairment of Several Immune Functions and Redox State in Blood Cells of Alzheimer's Disease Patients. Relevant Role of Neutrophils in Oxidative Stress. / 2017 / PubMed / Full text
[Effect of saponins extracted from Panax japonicus on inhibiting cardiomyocyte apoptosis by AMPK/Sirt1/NF-κB signaling pathway in aging rats]. / 12.2017 / PubMed / Full text
Premature aging in behavior and immune functions in tyrosine hydroxylase haploinsufficient female mice. A longitudinal study. / 03.2018 / PubMed / Full text
Differential microRNA expression profiles and bioinformatics analysis between young and aging spontaneously hypertensive rats. / 03.2018 / PubMed / Full text
Antagonism of cysteinyl leukotriene receptor 1 (cysLTR1) by montelukast suppresses cell senescence of chondrocytes. / 03.2018 / PubMed / Full text
Rapamycin prevents the intervertebral disc degeneration via inhibiting differentiation and senescence of annulus fibrosus cells. / 18.01.2018 / PubMed / Full text
Memory enhancement and protective effects of crocin against D-galactose aging model in the hippocampus of Wistar rats. / 11.2017 / PubMed / Full text
The additive effect of aging on sepsis-induced cognitive impairment and neuroinflammation. / 15.01.2018 / PubMed / Full text
Cytomegalovirus-Specific T Cells Restricted by HLA-Cw*0702 Increase Markedly with Age and Dominate the CD8 T-Cell Repertoire in Older People. / 2017 / PubMed / Full text
Polar extract of Curcuma longa protects cartilage homeostasis: possible mechanism of action. / 10.2018 / PubMed / Full text
Immunoglobulin therapy ameliorates the phenotype and increases lifespan in the severely affected dystrophin-utrophin double knockout mice. / 12.2017 / PubMed / Full text
The Association between Modulating Inflammatory Cytokines and Constipation of Geriatrics in Iran. / 10.2017 / PubMed / Full text
Immune senescence and biomarkers profile of Bambuí aged population-based cohort. / 03.2018 / PubMed / Full text
SIRT6 histone deacetylase functions as a potential oncogene in human melanoma. / 09.2017 / PubMed / Full text
TNF-α antagonism with etanercept enhances penile NOS expression, cavernosal reactivity, and testosterone levels in aged rats. / 02.2018 / PubMed / Full text
Dietary Animal Plasma Proteins Improve the Intestinal Immune Response in Senescent Mice. / 11.12.2017 / PubMed / Full text
Effects of the Consumption of Milk Biofortified with Selenium, Vitamin E, and Different Fatty Acid Profile on Immune Response in the Elderly. / 02.2018 / PubMed / Full text
Phase angle is related with inflammatory and oxidative stress biomarkers in older women. / 02.2018 / PubMed / Full text
Practice Patterns in Hepatitis B Virus Screening Before Cancer Chemotherapy in a Major US Hospital Network. / 01.2018 / PubMed / Full text
Insulin-Like Growth Factor-1 and Neuroinflammation. / 2017 / PubMed / Full text
Enhancement of cutaneous immunity during aging by blocking p38 mitogen-activated protein (MAP) kinase-induced inflammation. / 09.2018 / PubMed / Full text
Fisetin as a caloric restriction mimetic protects rat brain against aging induced oxidative stress, apoptosis and neurodegeneration. / 15.01.2018 / PubMed / Full text
Tucum-do-Cerrado (Bactris setosa Mart.) May Promote Anti-Aging Effect by Upregulating SIRT1-Nrf2 Pathway and Attenuating Oxidative Stress and Inflammation. / 14.11.2017 / PubMed / Full text
Time-response characteristic and potential biomarker identification of heavy metal induced toxicity in zebrafish. / 01.2018 / PubMed / Full text
Targeting of AUF1 to vascular endothelial cells as a novel anti-aging therapy. / 08.2017 / PubMed / Full text
Age-related decline of the acute local inflammation response: a mitigating role for the adenosine A receptor. / 18.10.2017 / PubMed / Full text
Anthocyanins Delay Ageing-Related Degenerative Changes in the Liver. / 12.2017 / PubMed / Full text
Nicotine-Induced Neuroprotection against Cognitive Dysfunction after Partial Hepatectomy Involves Activation of BDNF/TrkB Signaling Pathway and Inhibition of NF-κB Signaling Pathway in Aged Rats. / 06.03.2018 / PubMed / Full text
Study of insulin vascular sensitivity in aortic rings and endothelial cells from aged rats subjected to caloric restriction: Role of perivascular adipose tissue. / 08.2018 / PubMed / Full text
Tumor necrosis factor-alpha and soluble TNF-alpha receptor responses in young vs. middle-aged males following eccentric exercise. / 15.12.2017 / PubMed / Full text
Chronic inflammation - inflammaging - in the ageing cochlea: A novel target for future presbycusis therapy. / 11.2017 / PubMed / Full text
Allogeneic Mesenchymal Stem Cells Ameliorate Aging Frailty: A Phase II Randomized, Double-Blind, Placebo-Controlled Clinical Trial. / 12.10.2017 / PubMed / Full text
Protective effect of xanthohumol against age-related brain damage. / 11.2017 / PubMed / Full text
7,8-Dihydroxyflavone attenuates TNF-α-induced skin aging in Hs68 human dermal fibroblast cells via down-regulation of the MAPKs/Akt signaling pathways. / 11.2017 / PubMed / Full text
Influenza vaccine-mediated protection in older adults: Impact of influenza infection, cytomegalovirus serostatus and vaccine dosage. / 01.07.2018 / PubMed / Full text
Aged blood factors decrease cellular responses associated with delayed gingival wound repair. / 2017 / PubMed / Full text
Age-associated alterations in the levels of cytotoxic lipid molecular species and oxidative stress in the murine thymus are reduced by growth hormone treatment. / 10.2017 / PubMed / Full text
Force-time characteristics during sustained maximal handgrip effort according to age and clinical condition. / 11.2017 / PubMed / Full text
[Age-related aspects of the involvement of heat shock proteins in the pathogenesis of osteoarthritis]. / 2017 / PubMed
Electroacupuncture alleviates surgery-induced cognitive dysfunction by increasing α7-nAChR expression and inhibiting inflammatory pathway in aged rats. / 17.10.2017 / PubMed / Full text
Association between local inflammation and breast tissue age-related lobular involution among premenopausal and postmenopausal breast cancer patients. / 2017 / PubMed / Full text
Cytochrome P450-2E1 is involved in aging-related kidney damage in mice through increased nitroxidative stress. / 11.2017 / PubMed / Full text
Tumor necrosis factor alpha polymorphisms are associated with Parkinson's disease age at onset. / 29.09.2017 / PubMed / Full text
Involvement of insulin resistance in D-galactose-induced age-related dementia in rats: Protective role of metformin and saxagliptin. / 2017 / PubMed / Full text
Lower levels of interleukin-1β gene expression are associated with impaired Langerhans' cell migration in aged human skin. / 01.2018 / PubMed / Full text
Predictive value of multiple cytokines and chemokines for mortality in an admixed population: 15-year follow-up of the Bambui-Epigen (Brazil) cohort study of aging. / 11.2017 / PubMed / Full text
Age-dependent alterations in serum cytokines, peripheral blood mononuclear cell cytokine production, natural killer cell activity, and prostaglandin F . / 10.2017 / PubMed / Full text
Role of Kallistatin Treatment in Aging and Cancer by Modulating miR-34a and miR-21 Expression. / 2017 / PubMed / Full text
Counts of MSC in the Bone Marrow of Young and Old CBA Mice after a Single Exposure to Osteogenic Stimuli (Curettage, BMP-2 Injection) or Antigens (S. typhimurium Antigenic Complex) and in Heterotopic Bone Marrow Transplants. / 07.2017 / PubMed / Full text
Effect of Exercise on Inflammatory Profile of Older Persons: Systematic Review and Meta-Analyses. / 01.01.2018 / PubMed / Full text
Emerging role of Interleukins IL-23/IL-17 axis and biochemical markers in the pathogenesis of Type 2 Diabetes: Association with age and gender in human subjects. / 12.2017 / PubMed / Full text
An Appropriate Modulation of Lymphoproliferative Response and Cytokine Release as Possible Contributors to Longevity. / 24.07.2017 / PubMed / Full text
Intestinal Permeability Biomarker Zonulin is Elevated in Healthy Aging. / 01.09.2017 / PubMed / Full text
Tumor-targeted IL-12 combined with local irradiation leads to systemic tumor control via abscopal effects [i]in vivo[/i]. / 2017 / PubMed / Full text
The relation between DNA methylation patterns and serum cytokine levels in community-dwelling adults: a preliminary study. / 21.06.2017 / PubMed / Full text
Critical role of TNF inhibition in combination therapy for elderly mice with atherosclerosis. / 12.2017 / PubMed / Full text
Structural characterization of a pectic polysaccharide from Codonopsis pilosula and its immunomodulatory activities in vivo and in vitro. / 11.2017 / PubMed / Full text
p21 maintains senescent cell viability under persistent DNA damage response by restraining JNK and caspase signaling. / 01.08.2017 / PubMed / Full text
A dual agonist of farnesoid X receptor (FXR) and the G protein-coupled receptor TGR5, INT-767, reverses age-related kidney disease in mice. / 21.07.2017 / PubMed / Full text
Deregulation of hsa-miR-20b expression in TNF-α-induced premature senescence of human pulmonary microvascular endothelial cells. / 11.2017 / PubMed / Full text
Identification of tissue-specific transcriptional markers of caloric restriction in the mouse and their use to evaluate caloric restriction mimetics. / 08.2017 / PubMed / Full text
Grip strength and inflammatory biomarker profiles in very old adults. / 01.11.2017 / PubMed / Full text
Anti-aging drugs reduce hypothalamic inflammation in a sex-specific manner. / 08.2017 / PubMed / Full text
Kallistatin reduces vascular senescence and aging by regulating microRNA-34a-SIRT1 pathway. / 08.2017 / PubMed / Full text
Role of Adipose Tissue Endothelial ADAM17 in Age-Related Coronary Microvascular Dysfunction. / 06.2017 / PubMed / Full text
Peritoneal carcinomatosis of colorectal cancer is characterized by structural and functional reorganization of the tumor microenvironment inducing senescence and proliferation arrest in cancer cells. / 2016 / PubMed / Full text
Inflammatory Markers and Risk for Cognitive Decline in Chronic Kidney Disease: The CRIC Study. / 03.2017 / PubMed / Full text
Short-Term Fructose Feeding Induces Inflammation and Oxidative Stress in the Hippocampus of Young and Adult Rats. / 04.2018 / PubMed / Full text
Allogeneic Human Mesenchymal Stem Cell Infusions for Aging Frailty. / 12.10.2017 / PubMed / Full text
The isozyme selective phosphodiesterase-4 inhibitor, ABI-4, attenuates the effects of lipopolysaccharide in human cells and rodent models of peripheral and CNS inflammation. / 08.2017 / PubMed / Full text
Age-Associated Microbial Dysbiosis Promotes Intestinal Permeability, Systemic Inflammation, and Macrophage Dysfunction. / 12.04.2017 / PubMed / Full text
Effects of vitamin D and resveratrol on metabolic associated markers in liver and adipose tissue from SAMP8 mice. / 07.2017 / PubMed / Full text
Novel Senescent Regulatory T-Cell Subset with Impaired Suppressive Function in Rheumatoid Arthritis. / 2017 / PubMed / Full text
Long-term culture with lipopolysaccharide induces dose-dependent cytostatic and cytotoxic effects in THP-1 monocytes. / 08.2017 / PubMed / Full text
Arginase-II Promotes Tumor Necrosis Factor-α Release From Pancreatic Acinar Cells Causing β-Cell Apoptosis in Aging. / 06.2017 / PubMed / Full text
Consumption of green tea epigallocatechin-3-gallate enhances systemic immune response, antioxidative capacity and HPA axis functions in aged male swiss albino mice. / 06.2017 / PubMed / Full text
17beta-estradiol Attenuates TNF-α-Induced Premature Senescence of Nucleus Pulposus Cells through Regulating the ROS/NF-κB Pathway. / 2017 / PubMed / Full text
Frailty and Circulating Markers of Inflammation in HIV and HIV- Men in the Multicenter AIDS Cohort Study. / 01.04.2017 / PubMed / Full text
Peripheral administration of the soluble TNF inhibitor XPro1595 modifies brain immune cell profiles, decreases beta-amyloid plaque load, and rescues impaired long-term potentiation in 5xFAD mice. / 06.2017 / PubMed / Full text
Interleukin-37 suppresses the inflammatory response to protect cardiac function in old endotoxemic mice. / 07.2017 / PubMed / Full text
From comorbidities of chronic obstructive pulmonary disease to identification of shared molecular mechanisms by data integration. / 22.11.2016 / PubMed / Full text
High Volume Exercise Training in Older Athletes Influences Inflammatory and Redox Responses to Acute Exercise. / 01.10.2017 / PubMed / Full text
β -Microglobulin participates in development of lung emphysema by inducing lung epithelial cell senescence. / 01.05.2017 / PubMed / Full text
CSF protein changes associated with hippocampal sclerosis risk gene variants highlight impact of GRN/PGRN. / 04.2017 / PubMed / Full text
CMV-Specific T-cell Responses at Older Ages: Broad Responses With a Large Central Memory Component May Be Key to Long-term Survival. / 15.04.2017 / PubMed / Full text
Association of TNF Receptor 2 and CRP with GFR Decline in the General Nondiabetic Population. / 03.04.2017 / PubMed / Full text
Age-dependent cellular reactions of the human immune system of humanized NOD scid gamma mice on LPS stimulus. / 04.2017 / PubMed / Full text
Tumor antigen-specific CD8 T cells are negatively regulated by PD-1 and Tim-3 in human gastric cancer. / 03.2017 / PubMed / Full text
Noni (Morinda citrifolia L.) fruit juice reverses age-related decline in neural-immune interactions in the spleens of old F344 rats. / 23.02.2017 / PubMed / Full text
Aging Affects Bone Marrow Macrophage Polarization: Relevance to Bone Healing. / 06.2016 / PubMed / Full text
Therapeutic effect of human ghrelin and growth hormone: Attenuation of immunosuppression in septic aged rats. / 10.2017 / PubMed / Full text
CD8 T cells of chronic HCV-infected patients express multiple negative immune checkpoints following stimulation with HCV peptides. / 03.2017 / PubMed / Full text
Microvasculature remodeling in the mouse lower gut during inflammaging. / 03.01.2017 / PubMed / Full text
The role of macrophages in the susceptibility of Fc gamma receptor IIb deficient mice to Cryptococcus neoformans. / 11.01.2017 / PubMed / Full text
"Inflamm-aging" influences immune cell survival factors in human bone marrow. / 03.2017 / PubMed / Full text
Analysis of molecular networks and targets mining of Chinese herbal medicines on anti-aging. / 28.12.2016 / PubMed / Full text
[Pathological state or cause of sarcopenia.] / 2017 / PubMed / Full text
Advanced atherosclerosis is associated with inflammation, vascular dysfunction and oxidative stress, but not hypertension. / 02.2017 / PubMed / Full text
Effect of Low-Dose Rapamycin on Senescence Markers and Physical Functioning in Older Adults with Coronary Artery Disease: Results of a Pilot Study. / 2016 / PubMed / Full text
Inverse relationship between Alzheimer's disease and cancer, and other factors contributing to Alzheimer's disease: a systematic review. / 22.11.2016 / PubMed / Full text
Antiaging Effect of Metformin on Brain in Naturally Aged and Accelerated Senescence Model of Rat. / 06.2017 / PubMed / Full text
Strength and Aerobic Exercises Improve Spatial Memory in Aging Rats Through Stimulating Distinct Neuroplasticity Mechanisms. / 12.2017 / PubMed / Full text
Low vaccination rates among patients with rheumatoid arthritis in a German outpatient clinic. / 02.2017 / PubMed / Full text
Palmitate promotes inflammatory responses and cellular senescence in cardiac fibroblasts. / 02.2017 / PubMed / Full text
Structural brain changes and all-cause mortality in the elderly population-the mediating role of inflammation. / 12.2016 / PubMed / Full text
Aging dysregulates D- and E-series resolvins to modulate cardiosplenic and cardiorenal network following myocardial infarction. / 18.10.2016 / PubMed / Full text
Age-Specific Adjuvant Synergy: Dual TLR7/8 and Mincle Activation of Human Newborn Dendritic Cells Enables Th1 Polarization. / 01.12.2016 / PubMed / Full text
Downregulation of kidney protective factors by inflammation: role of transcription factors and epigenetic mechanisms. / 01.12.2016 / PubMed / Full text
Strain-dependent response to stimulation in middle-aged rat macrophages: A quest after a useful indicator of healthy aging. / 01.12.2016 / PubMed / Full text
A reverse genetics cell-based evaluation of genes linked to healthy human tissue age. / 01.2017 / PubMed / Full text
Longevity-Associated FOXO3 Genotype and its Impact on Coronary Artery Disease Mortality in Japanese, Whites, and Blacks: A Prospective Study of Three American Populations. / 01.05.2017 / PubMed / Full text
Polydatin attenuates d-galactose-induced liver and brain damage through its anti-oxidative, anti-inflammatory and anti-apoptotic effects in mice. / 09.11.2016 / PubMed / Full text
Selenium attenuates apoptosis, inflammation and oxidative stress in the blood and brain of aged rats with scopolamine-induced dementia. / 04.2017 / PubMed / Full text
Cartilage damage and bone erosion are more prominent determinants of functional impairment in longstanding experimental arthritis than synovial inflammation. / 01.11.2016 / PubMed / Full text
Aging increases the susceptibility of hepatic inflammation, liver fibrosis and aging in response to high-fat diet in mice. / 08.2016 / PubMed / Full text
The individual and combined effects of obesity- and ageing-induced systemic inflammation on human skeletal muscle properties. / 01.2017 / PubMed / Full text
Thymopentin improves cardiac function in older patients with chronic heart failure. / 01.2017 / PubMed / Full text
Aging-Associated TNF Production Primes Inflammasome Activation and NLRP3-Related Metabolic Disturbances. / 01.10.2016 / PubMed / Full text
[Molecular Mechanisms of Functional Activity Decreasing of the Skin Cells With Its Aging]. / 04-06.2016 / PubMed
Metallothionein Prevents Age-Associated Cardiomyopathy via Inhibiting NF-κB Pathway Activation and Associated Nitrative Damage to 2-OGD. / 10.12.2016 / PubMed / Full text
Long-term hippocampal glutamate synapse and astrocyte dysfunctions underlying the altered phenotype induced by adolescent THC treatment in male rats. / 09.2016 / PubMed / Full text
Amlodipine and atorvastatin improve ventricular hypertrophy and diastolic function via inhibiting TNF-α, IL-1β and NF-κB inflammatory cytokine networks in elderly spontaneously hypertensive rats. / 10.2016 / PubMed / Full text
Long-term moderate calorie restriction inhibits inflammation without impairing cell-mediated immunity: a randomized controlled trial in non-obese humans. / 07.2016 / PubMed / Full text
Vδ2 and α/ß T cells show divergent trajectories during human aging. / 19.07.2016 / PubMed / Full text
Inflammatory Markers and the Risk of Hip and Vertebral Fractures in Men: the Osteoporotic Fractures in Men (MrOS). / 12.2016 / PubMed / Full text
Berberine alleviates postoperative cognitive dysfunction by suppressing neuroinflammation in aged mice. / 09.2016 / PubMed / Full text
Sex differences in the response to resistance exercise training in older people. / 06.2016 / PubMed / Full text
The Role of Oxidative Stress in Etiopathogenesis of Chemotherapy Induced Cognitive Impairment (CICI)-"Chemobrain". / 05.2016 / PubMed / Full text
Age-associated impairment of antitumor immunity in carcinoma-bearing mice and restoration by oral administration of Lentinula edodes mycelia extract. / 08.2016 / PubMed / Full text
Age-related accumulation of advanced glycation end-products-albumin, S100β, and the expressions of advanced glycation end product receptor differ in visceral and subcutaneous fat. / 19.08.2016 / PubMed / Full text
Genetic variation and exercise-induced muscle damage: implications for athletic performance, injury and ageing. / 09.2016 / PubMed / Full text
Role of androgens in dhea-induced rack1 expression and cytokine modulation in monocytes. / 2016 / PubMed / Full text
Transcriptome analysis of human ageing in male skin shows mid-life period of variability and central role of NF-κB. / 27.05.2016 / PubMed / Full text
PMK-S005 Alleviates Age-Related Gastric Acid Secretion, Inflammation, and Oxidative Status in the Rat Stomach. / 15.09.2016 / PubMed / Full text
Physical activity and inflammation: effects on gray-matter volume and cognitive decline in aging. / 10.2016 / PubMed / Full text
Intramembrane proteolysis within lysosomes. / 12.2016 / PubMed / Full text
Characterization of the anti-inflammatory Lactobacillus reuteri BM36301 and its probiotic benefits on aged mice. / 19.04.2016 / PubMed / Full text
The anti-aging effects of LW-AFC via correcting immune dysfunctions in senescence accelerated mouse resistant 1 (SAMR1) strain. / 10.05.2016 / PubMed / Full text
The impact of adjuvant chemotherapy in older breast cancer patients on clinical and biological aging parameters. / 24.05.2016 / PubMed / Full text
Role of mitochondrial function in cell death and body metabolism. / 01.06.2016 / PubMed / Full text
[Effect of flavonoids from Sophora flavescens in aging mice induced by D-galactos]. / 11.2015 / PubMed
Ex vivo foam cell formation is enhanced in monocytes from older individuals by both extrinsic and intrinsic mechanisms. / 07.2016 / PubMed / Full text
In vitro cytokine induction by TLR-activating vaccine adjuvants in human blood varies by age and adjuvant. / 07.2016 / PubMed / Full text
Joint effect of gene-physical activity and the interactions among CRP, TNF-α, and LTA polymorphisms on serum CRP, TNF-α levels, and handgrip strength in community-dwelling elders in Taiwan - TCHS-E. / 04.2016 / PubMed / Full text
Hippocampal Astrocyte Cultures from Adult and Aged Rats Reproduce Changes in Glial Functionality Observed in the Aging Brain. / 05.2017 / PubMed / Full text
Wound healing delays in α-Klotho-deficient mice that have skin appearance similar to that in aged humans - Study of delayed wound healing mechanism. / 13.05.2016 / PubMed / Full text
Lipid-laden cells differentially distributed in the aging brain are functionally active and correspond to distinct phenotypes. / 31.03.2016 / PubMed / Full text
ECG low QRS voltage and wide QRS complex predictive of centenarian 360-day mortality. / 04.2016 / PubMed / Full text
Fibrillar Amyloid-β Accumulation Triggers an Inflammatory Mechanism Leading to Hyperphosphorylation of the Carboxyl-Terminal End of Tau Polypeptide in the Hippocampal Formation of the 3×Tg-AD Transgenic Mouse. / 22.03.2016 / PubMed / Full text
Regular Physical Activity and Vascular Aging. / 2016 / PubMed / Full text
Epigenetic mechanisms underlying cognitive impairment and Alzheimer disease hallmarks in 5XFAD mice. / 04.2016 / PubMed / Full text
Air pollution and skin diseases: Adverse effects of airborne particulate matter on various skin diseases. / 01.05.2016 / PubMed / Full text
Aging Converts Innate B1a Cells into Potent CD8 T Cell Inducers. / 15.04.2016 / PubMed / Full text
Effects of Hydrogen-Rich Saline on Hepatectomy-Induced Postoperative Cognitive Dysfunction in Old Mice. / 05.2017 / PubMed / Full text
Age-Associated Resident Memory CD8 T Cells in the Central Nervous System Are Primed To Potentiate Inflammation after Ischemic Brain Injury. / 15.04.2016 / PubMed / Full text
Ageing/Menopausal Status in Healthy Women and Ageing in Healthy Men Differently Affect Cardiometabolic Parameters. / 2016 / PubMed / Full text
Anti-TNF-α treatment modulates SASP and SASP-related microRNAs in endothelial cells and in circulating angiogenic cells. / 15.03.2016 / PubMed / Full text
Agmatine Ameliorates High Glucose-Induced Neuronal Cell Senescence by Regulating the p21 and p53 Signaling. / 02.2016 / PubMed / Full text
[IMMUNE PARAMETERS OF SALIVA IN PERSONS OF DIFFERENT AGE RESIDING IN ST. PETERSBURG AND LENINGRAD REGION]. / 2015 / PubMed
Effects of Ageing on the Immune System: Infants to Elderly. / 04.2016 / PubMed / Full text
Targeting local vascular and systemic consequences of inflammation on vascular and cardiac valve calcification. / 2016 / PubMed / Full text
Docosahexaenoic acid prevented tumor necrosis factor alpha-induced endothelial dysfunction and senescence. / 01.2016 / PubMed / Full text
TNF Drives Monocyte Dysfunction with Age and Results in Impaired Anti-pneumococcal Immunity. / 01.2016 / PubMed / Full text
Association of longevity with TNF-α G308A and IL-6 G174C polymorphic inflammatory biomarkers in Caucasians: a meta-analysis. / 12.2016 / PubMed / Full text
Effect of Aging on Periodontal Inflammation, Microbial Colonization, and Disease Susceptibility. / 04.2016 / PubMed / Full text
Sirt6 regulates dendritic cell differentiation, maturation, and function. / 01.2016 / PubMed / Full text
Aging-dependent decline of IL-10 producing B cells coincides with production of antinuclear antibodies but not rheumatoid factors. / 03.2016 / PubMed / Full text
Kupffer cells-dependent inflammation in the injured liver increases recruitment of mesenchymal stem cells in aging mice. / 12.01.2016 / PubMed / Full text
Interaction of mouse splenocytes and macrophages with bacterial strains in vitro: the effect of age in the immune response. / 2016 / PubMed / Full text
Impairment of biliverdin reductase-A promotes brain insulin resistance in Alzheimer disease: A new paradigm. / 02.2016 / PubMed / Full text
Role of SHOX2 in the development of intervertebral disc degeneration. / 05.2017 / PubMed / Full text
Melatonin decreases the expression of inflammation and apoptosis markers in the lung of a senescence-accelerated mice model. / 03.2016 / PubMed / Full text
Age-related neuroinflammation and changes in AKT-GSK-3β and WNT/ β-CATENIN signaling in rat hippocampus. / 12.2015 / PubMed / Full text
Aging has small effects on initial ischemic acute kidney injury development despite changing intrarenal immunologic micromilieu in mice. / 15.02.2016 / PubMed / Full text
Inflammaging and Anti-Inflammaging: The Role of Cytokines in Extreme Longevity. / 04.2016 / PubMed / Full text
Effect of ZIP2 Gln/Arg/Leu (rs2234632) polymorphism on zinc homeostasis and inflammatory response following zinc supplementation. / 11-12.2015 / PubMed / Full text
Ageing and the telomere connection: An intimate relationship with inflammation. / 01.2016 / PubMed / Full text
Responses of Dendritic Cells to TLR-4 Stimulation Are Maintained in the Elderly and Resist the Effects of CMV Infection Seen in the Young. / 09.2016 / PubMed / Full text
Dietary supplementation with the polyphenol-rich açaí pulps (Euterpe oleracea Mart. and Euterpe precatoria Mart.) improves cognition in aged rats and attenuates inflammatory signaling in BV-2 microglial cells. / 05.2017 / PubMed / Full text
Age and diabetes related changes of the retinal capillaries: An ultrastructural and immunohistochemical study. / 03.2016 / PubMed / Full text
Melatonin Counteracts at a Transcriptional Level the Inflammatory and Apoptotic Response Secondary to Ischemic Brain Injury Induced by Middle Cerebral Artery Blockade in Aging Rats. / 2015 / PubMed / Full text
The relationship between inflammatory markers and voxel-based gray matter volumes in nondemented older adults. / 01.2016 / PubMed / Full text
Change in N-Glycosylation of Plasma Proteins in Japanese Semisupercentenarians. / 2015 / PubMed / Full text
Telomerase Deficiency Causes Alveolar Stem Cell Senescence-associated Low-grade Inflammation in Lungs. / 25.12.2015 / PubMed / Full text
Prognostic impact of circulating Her-2-reactive T-cells producing pro- and/or anti-inflammatory cytokines in elderly breast cancer patients. / 2015 / PubMed / Full text
Age differences in cytokine expression under conditions of health using experimental pain models. / 12.2015 / PubMed / Full text
CLARITY and PACT-based imaging of adult zebrafish and mouse for whole-animal analysis of infections. / 12.2015 / PubMed / Full text
[Rich selenium-Banqiao-Codonopsis Pilosula mixture enhances immune function of aging mice]. / 10.2015 / PubMed
Estrogen upregulates inflammatory signals through NF-κB, IFN-γ, and nitric oxide via Akt/mTOR pathway in the lymph node lymphocytes of middle-aged female rats. / 12.2015 / PubMed / Full text
Influence of caffeine on 3,4-methylenedioxymethamphetamine-induced dopaminergic neuron degeneration and neuroinflammation is age-dependent. / 01.2016 / PubMed / Full text
Associations of Circulating Soluble Tumor Necrosis Factor-α Receptors 1 and 2 with Interleukin-6 Levels in an Aging Cohort of Injection Drug Users with or at High Risk for HIV Infection. / 12.2015 / PubMed / Full text
Chronic inflammation and risk of colorectal and other obesity-related cancers: The health, aging and body composition study. / 01.03.2016 / PubMed / Full text
IL-17A is implicated in lipopolysaccharide-induced neuroinflammation and cognitive impairment in aged rats via microglial activation. / 15.09.2015 / PubMed / Full text
A Mitochondrion-Targeted Antioxidant Ameliorates Isoflurane-Induced Cognitive Deficits in Aging Mice. / 2015 / PubMed / Full text
Exacerbation of tumor necrosis factor-induced vascular leak syndrome by aging. / 08.2015 / PubMed / Full text
Skeletal muscle cells possess a 'memory' of acute early life TNF-α exposure: role of epigenetic adaptation. / 06.2016 / PubMed / Full text
Migrational changes of mesenchymal stem cells in response to cytokines, growth factors, hypoxia, and aging. / 15.10.2015 / PubMed / Full text
GADD34-deficient mice develop obesity, nonalcoholic fatty liver disease, hepatic carcinoma and insulin resistance. / 28.08.2015 / PubMed / Full text
Effects of 6-month supplementation with β-hydroxy-β-methylbutyrate, glutamine and arginine on vascular endothelial function of older adults. / 02.2016 / PubMed / Full text
Monocyte Phenotype and Polyfunctionality Are Associated With Elevated Soluble Inflammatory Markers, Cytomegalovirus Infection, and Functional and Cognitive Decline in Elderly Adults. / 05.2016 / PubMed / Full text
Age-related increased prevalence of asthma and nasal polyps in chronic rhinosinusitis and its association with altered IL-6 trans-signaling. / 11.2015 / PubMed / Full text
Inflammatory Markers Change with Age, but do not Fall Beyond Reported Normal Ranges. / 06.2016 / PubMed / Full text
Oral treatment with herbal formula B307 alleviates cardiac failure in aging R6/2 mice with Huntington's disease via suppressing oxidative stress, inflammation, and apoptosis. / 2015 / PubMed / Full text
Plasma TNF-α Is Associated with Inflammation and Nutrition Status in Community-Dwelling Japanese Elderly. / 2015 / PubMed / Full text
Senescent profile of angiogenic T cells from systemic lupus erythematosus patients. / 03.2016 / PubMed / Full text
Effects of home-based bench step exercise on inflammatory cytokines and lipid profiles in elderly Japanese females: A randomized controlled trial. / 11-12.2015 / PubMed / Full text
Neuroimmune and Neuropathic Responses of Spinal Cord and Dorsal Root Ganglia in Middle Age. / 2015 / PubMed / Full text
The effect of ladder-climbing exercise on atrophy/hypertrophy-related myokine expression in middle-aged male Wistar rats. / 11.2015 / PubMed / Full text
Sleep fragmentation and sepsis differentially impact blood-brain barrier integrity and transport of tumor necrosis factor-α in aging. / 11.2015 / PubMed / Full text
Mitochondria-targeted antioxidant SkQ1 improves impaired dermal wound healing in old mice. / 07.2015 / PubMed / Full text
Role of vascular peroxidase 1 in senescence of endothelial cells in diabetes rats. / 15.10.2015 / PubMed / Full text
[Association between carbonyl proteins and tumor necrosis factor alpha with muscle strength in young and older women: exploratory study]. / 11-12.2015 / PubMed / Full text
LIPID PROFILE AND CYTOKINES INTERACTIONS DURING SUCCESSFUL AGING. / 06.2015 / PubMed
Age-Dependent Alterations in the Interactions of NF-κB and N-myc with GLT-1/EAAT2 Promoter in the Pericontusional Cortex of Mice Subjected to Traumatic Brain Injury. / 07.2016 / PubMed / Full text
The Werner Protein Acts as a Coactivator of Nuclear Factor κB (NF-κB) on HIV-1 and Interleukin-8 (IL-8) Promoters. / 24.07.2015 / PubMed / Full text
Interleukin-6 as a first-rated serum inflammatory marker to predict mortality and hospitalization in the oldest old: A regression and CART approach in the BELFRAIL study. / 09.2015 / PubMed / Full text
Microglial Kv1.3 Channels and P2Y12 Receptors Differentially Regulate Cytokine and Chemokine Release from Brain Slices of Young Adult and Aged Mice. / 2015 / PubMed / Full text
Bile acid mediated effects on gut integrity and performance of early-weaned piglets. / 14.05.2015 / PubMed / Full text
Increased serum levels of eotaxin/CCL11 in late-stage patients with bipolar disorder: An accelerated aging biomarker? / 15.08.2015 / PubMed / Full text
Vascular endothelial function is improved by oral glycine treatment in aged rats. / 06.2015 / PubMed / Full text
Inhibition of hedgehog signalling attenuates UVB-induced skin photoageing. / 08.2015 / PubMed / Full text
Age-associated modifications of intestinal permeability and innate immunity in human small intestine. / 10.2015 / PubMed / Full text
The stimulatory effect of the TLR4-mediated adjuvant glucopyranosyl lipid A is well preserved in old age. / 02.2016 / PubMed / Full text
Inhibiting tumor necrosis factor-α signaling attenuates postoperative cognitive dysfunction in aged rats. / 08.2015 / PubMed / Full text
Female PAPP-A knockout mice are resistant to metabolic dysfunction induced by high-fat/high-sucrose feeding at middle age. / 06.2015 / PubMed / Full text
[Molecular mechanisms of combined extremely radiofrequency and infrared therapy in various age patients with chronic parodontitis]. / 2014 / PubMed
Exercise training increases anabolic and attenuates catabolic and apoptotic processes in aged skeletal muscle of male rats. / 07.2015 / PubMed / Full text
Transient early food restriction leads to hypothalamic changes in the long-lived crowded litter female mice. / 04.2015 / PubMed / Full text
The probiotic mixture IRT5 ameliorates age-dependent colitis in rats. / 06.2015 / PubMed / Full text
Essential role of POLDIP2 in Tau aggregation and neurotoxicity via autophagy/proteasome inhibition. / 26.06.2015 / PubMed / Full text
Inflammaging decreases adaptive and innate immune responses in mice and humans. / 02.2016 / PubMed / Full text
Methyl-CpG Binding Protein 2 Regulates Microglia and Macrophage Gene Expression in Response to Inflammatory Stimuli. / 21.04.2015 / PubMed / Full text
Relationship between biomarkers of inflammation, oxidative stress and endothelial/microcirculatory function in successful aging versus healthy youth: a transversal study. / 08.04.2015 / PubMed / Full text
No strong correlations between serum cytokine levels, CMV serostatus and hand-grip strength in older subjects in the Berlin BASE-II cohort. / 02.2016 / PubMed / Full text
Fibroblast growth factor 21 protects mouse brain against D-galactose induced aging via suppression of oxidative stress response and advanced glycation end products formation. / 06.2015 / PubMed / Full text
The p53/miR-17/Smurf1 pathway mediates skeletal deformities in an age-related model via inhibiting the function of mesenchymal stem cells. / 03.2015 / PubMed / Full text
Acute exercise increases hippocampal TNF-α, Caspase-3 and Caspase-7 expression in healthy young and older mice. / 04.2015 / PubMed
Autophagy in axonal degeneration in glaucomatous optic neuropathy. / 07.2015 / PubMed / Full text
Prophylactic lithium alleviates splenectomy-induced cognitive dysfunction possibly by inhibiting hippocampal TLR4 activation in aged rats. / 05.2015 / PubMed / Full text
Blood-brain barrier dysfunction developed during normal aging is associated with inflammation and loss of tight junctions but not with leukocyte recruitment. / 2015 / PubMed / Full text
Association of systemic inflammation with epicardial fat and coronary artery calcification. / 05.2015 / PubMed / Full text
Age-associated changes in granulosa cell transcript abundance in equine preovulatory follicles. / 07.2015 / PubMed / Full text
Effects of er-miao-san extracts on TNF-alpha-induced MMP-1 expression in human dermal fibroblasts. / 26.01.2015 / PubMed / Full text
Immunostimulatory effects of RACK1 pseudosubstrate in human leukocytes obtained from young and old donors. / 30.03.2015 / PubMed / Full text
Patient-relevant endpoints in inflammatory bowel diseases--have changes occurred in Germany over the past twelve years? / 05.2015 / PubMed / Full text
Anti-inflammatory effect of resveratrol in old mice liver. / 04.2015 / PubMed / Full text
Blockade of PD-1 or p38 MAP kinase signaling enhances senescent human CD8( ) T-cell proliferation by distinct pathways. / 05.2015 / PubMed / Full text
Circulating TNF and mitochondrial DNA are major determinants of neutrophil phenotype in the advanced-age, frail elderly. / 05.2015 / PubMed / Full text
Salidroside protects against premature senescence induced by ultraviolet B irradiation in human dermal fibroblasts. / 06.2015 / PubMed / Full text
Selected pro- and anti-inflammatory cytokines in cerebrospinal fluid in normal pressure hydrocephalus. / 2014 / PubMed
Vaginal cytokines do not correlate with postmenopausal vulvovaginal symptoms. / 04.2015 / PubMed / Full text
Age-related differences in polyfunctional T cell responses. / 2014 / PubMed / Full text
Anti-apoptotic and anti-glycative effects of asiatic acid in the brain of D-galactose treated mice. / 02.2015 / PubMed / Full text
Dexmedetomidine improves early postoperative cognitive dysfunction in aged mice. / 05.01.2015 / PubMed / Full text
Tumor necrosis factor-α-accelerated degradation of type I collagen in human skin is associated with elevated matrix metalloproteinase (MMP)-1 and MMP-3 ex vivo. / 01.2015 / PubMed / Full text
Sodium nitrite supplementation improves motor function and skeletal muscle inflammatory profile in old male mice. / 15.01.2015 / PubMed / Full text
Pre-Operative, High-IL-6 Blood Level is a Risk Factor of Post-Operative Delirium Onset in Old Patients. / 2014 / PubMed / Full text
Low-grade systemic inflammation connects aging, metabolic syndrome and cardiovascular disease. / 2015 / PubMed / Full text
Inflammasomes in neuroinflammation and changes in brain function: a focused review. / 2014 / PubMed / Full text
Impact of gasless laparoscopy on circulation, respiration, stress response, and other complications in gynecological geriatrics. / 2014 / PubMed / Full text
Adiposity induces lethal cytokine storm after systemic administration of stimulatory immunotherapy regimens in aged mice. / 17.11.2014 / PubMed / Full text
Sleep deprivation and divergent toll-like receptor-4 activation of cellular inflammation in aging. / 01.02.2015 / PubMed / Full text
Elevated Endoplasmic Reticulum Stress Response Contributes to Adipose Tissue Inflammation in Aging. / 11.2015 / PubMed / Full text
The SIRT1 activator SRT1720 reverses vascular endothelial dysfunction, excessive superoxide production, and inflammation with aging in mice. / 15.12.2014 / PubMed / Full text
Evidence for altered inflammatory and repair responses in symptomatic carotid plaques from elderly patients. / 11.2014 / PubMed / Full text
Immunosenescence in monocytes, macrophages, and dendritic cells: lessons learned from the lung and heart. / 11.2014 / PubMed / Full text
Ferrocifen derivatives that induce senescence in cancer cells: selected examples. / 12.2014 / PubMed / Full text
Role of mitochondrial reactive oxygen species in age-related inflammatory activation of endothelium. / 08.2014 / PubMed / Full text
Aging differentially affects the loss of neuronal dendritic spine, neuroinflammation and memory impairment at rats after surgery. / 2014 / PubMed / Full text
Simultaneous monitoring of cerebral metal accumulation in an experimental model of Wilson's disease by laser ablation inductively coupled plasma mass spectrometry. / 20.08.2014 / PubMed / Full text
Interleukin-1 deficiency prolongs ovarian lifespan in mice. / 26.08.2014 / PubMed / Full text
HIV-1 transgenic rats display alterations in immunophenotype and cellular responses associated with aging. / 2014 / PubMed / Full text
Aging and the burden of multimorbidity: associations with inflammatory and anabolic hormonal biomarkers. / 01.2015 / PubMed / Full text
Relationship between vitamin D and inflammatory markers in older individuals. / 2014 / PubMed / Full text
Association of pulse pressure with serum TNF-α and neutrophil count in the elderly. / 2014 / PubMed / Full text
Peritoneal exudate cells from long-lived rats exhibit increased IL-10/IL-1β expression ratio and preserved NO/urea ratio following LPS-stimulation in vitro. / 2014 / PubMed / Full text
Cortisol, cytokines, and hippocampal volume interactions in the elderly. / 2014 / PubMed / Full text
DaoTan decoction (DTD) inhibits tumor necrosis factor-α (TNF-α)-induced expression of intercellular adhesion molecule-1 (ICAM-1), p53 and p21, in human umbilical vein endothelia cells (HUVECs). / 10.2014 / PubMed / Full text
Improvement in Th1/Th2 immune homeostasis, antioxidative status and resistance to pathogenic E. coli on consumption of probiotic Lactobacillus rhamnosus fermented milk in aging mice. / 2014 / PubMed / Full text
Aging oppositely affects TNF-α and IL-10 production by macrophages from different rat strains. / 2014 / PubMed / Full text
Ginsenoside Rg1 prevents cognitive impairment and hippocampus senescence in a rat model of D-galactose-induced aging. / 2014 / PubMed / Full text
iPLA2β knockout mouse, a genetic model for progressive human motor disorders, develops age-related neuropathology. / 08.2014 / PubMed / Full text
Site-specific changes in cytokine response to septic dose of lipopolysaccharide in ovariectomized female rats. / 08.2014 / PubMed / Full text
D-galactose induced inflammation lipid peroxidation and platelet activation in rats. / 09.2014 / PubMed / Full text
Intramuscular fat and inflammation differ in older adults: the impact of frailty and inactivity. / 05.2014 / PubMed / Full text
Bacteria and Toll-like receptor and cytokine mRNA expression profiles associated with canine arthritis. / 15.08.2014 / PubMed / Full text
Distinct age-matched serum biomarker profiles in patients with cutaneous T-cell lymphoma. / 08.2014 / PubMed / Full text
Age-related activation of MKK/p38/NF-κB signaling pathway in lung: from mouse to human. / 09.2014 / PubMed / Full text
Changes in the expression of the Toll-like receptor system in the aging rat kidneys. / 2014 / PubMed / Full text
Comparative analysis of low-level laser therapy (660 nm) on inflammatory biomarker expression during the skin wound-repair process in young and aged rats. / 09.2014 / PubMed / Full text
Inflammation and prolonged QT time: results from the Cardiovascular Disease, Living and Ageing in Halle (CARLA) study. / 2014 / PubMed / Full text
Dendritic cells from aged subjects contribute to chronic airway inflammation by activating bronchial epithelial cells under steady state. / 11.2014 / PubMed / Full text
Impaired neutrophil extracellular trap formation: a novel defect in the innate immune system of aged individuals. / 08.2014 / PubMed / Full text
Maturation of innate responses to mycobacteria over the first nine months of life. / 15.05.2014 / PubMed / Full text
Effects of age and macrophage lineage on intracellular survival and cytokine induction after infection with Rhodococcus equi. / 15.07.2014 / PubMed / Full text
IL-2/CD40-activated macrophages rescue age and tumor-induced T cell dysfunction in elderly mice. / 06.2014 / PubMed / Full text
A comparison of pro-inflammatory cytokine mRNA expression in equine bronchoalveolar lavage (BAL) and peripheral blood. / 15.04.2014 / PubMed / Full text
Moderate swimming exercise and caffeine supplementation reduce the levels of inflammatory cytokines without causing oxidative stress in tissues of middle-aged rats. / 05.2014 / PubMed / Full text
Effects of aging on influenza virus infection dynamics. / 04.2014 / PubMed / Full text
Circulating mitochondrial DNA increases with age and is a familiar trait: Implications for "inflamm-aging". / 05.2014 / PubMed / Full text
Markers of low-grade inflammation and endothelial dysfunction are related to reduced information processing speed and executive functioning in an older population - the Hoorn Study. / 02.2014 / PubMed / Full text
Bacopa monnieri (L.) exerts anti-inflammatory effects on cells of the innate immune system in vitro. / 03.2014 / PubMed / Full text
Resveratrol increases antioxidant defenses and decreases proinflammatory cytokines in hippocampal astrocyte cultures from newborn, adult and aged Wistar rats. / 06.2014 / PubMed / Full text
High TNF-α levels in resting B cells negatively correlate with their response. / 06.2014 / PubMed / Full text
Cytomegalovirus infection modulates the phenotype and functional profile of the T-cell immune response to mycobacterial antigens in older life. / 06.2014 / PubMed / Full text
Deleterious effects of aggressive rapid crystalloid resuscitation on treatment of hyperinflammatory response and lung injury induced by hemorrhage in aging rats. / 04.2014 / PubMed / Full text
Soluble tumor necrosis factor receptors and heart failure risk in older adults: Health, Aging, and Body Composition (Health ABC) Study. / 01.2014 / PubMed / Full text
Life-long endurance exercise in humans: circulating levels of inflammatory markers and leg muscle size. / 11-12.2013 / PubMed / Full text
Study of antitumor activity of antibodies to TNF-α on Walker carcinosarcoma model. / 09.2013 / PubMed / Full text
Voluntary wheel running does not affect lipopolysaccharide-induced depressive-like behavior in young adult and aged mice. / 2014 / PubMed / Full text
Dysregulated FOXO transcription factors in articular cartilage in aging and osteoarthritis. / 01.2014 / PubMed / Full text
Chronic alcohol consumption disrupts myocardial protein balance and function in aged, but not adult, female F344 rats. / 01.01.2014 / PubMed / Full text
Association among 1267 A/G HSP70-2, -308 G/A TNF-α polymorphisms and pro-inflammatory plasma mediators in old ZincAge population. / 02.2014 / PubMed / Full text
Diabetes, depressive symptoms, and inflammation in older adults: results from the Health, Aging, and Body Composition Study. / 11.2013 / PubMed / Full text
Age effects on mouse and human B cells. / 12.2013 / PubMed / Full text
Limited utility of adipokine levels in the diagnosis of malnutrition in the elderly. / 04.2014 / PubMed / Full text
Systemic inflammatory responses and lung injury following hip fracture surgery increases susceptibility to infection in aged rats. / 2013 / PubMed / Full text
Analysis of cognition, motor performance and anxiety in young and aged tumor necrosis factor alpha receptor 1 and 2 deficient mice. / 01.01.2014 / PubMed / Full text
Hip fracture aggravates systemic inflammation and lung injury in aged chronic cigarette smoke exposed rats. / 01.2014 / PubMed / Full text
Probiotic modulation of dendritic cell function is influenced by ageing. / 02.2014 / PubMed / Full text
Aging predisposes to acute inflammatory induced pathology after tumor immunotherapy. / 21.10.2013 / PubMed / Full text
Association of inflammation with loss of ability to walk 400 meters: longitudinal findings from the Invecchiare in Chianti Study. / 10.2013 / PubMed / Full text
Elevated COX2 expression and PGE2 production by downregulation of RXRα in senescent macrophages. / 11.10.2013 / PubMed / Full text
Tumor necrosis factor-α inhibition improves endothelial function and decreases arterial stiffness in estrogen-deficient postmenopausal women. / 10.2013 / PubMed / Full text
Effects of ethanol on immune response in the brain: region-specific changes in adolescent versus adult mice. / 02.2014 / PubMed / Full text
Aging enhances release of exosomal cytokine mRNAs by Aβ1-42-stimulated macrophages. / 12.2013 / PubMed / Full text
Dendritic cells from the elderly display an intrinsic defect in the production of IL-10 in response to lithium chloride. / 11.2013 / PubMed / Full text
Longitudinal analysis of short-term high-fat diet on endothelial senescence in baboons. / 2013 / PubMed / Full text
Combined administration of oseltamivir and hochu-ekki-to (TJ-41) dramatically decreases the viral load in lungs of senescence-accelerated mice during influenza virus infection. / 02.2014 / PubMed / Full text
ADAMTS-7 forms a positive feedback loop with TNF-α in the pathogenesis of osteoarthritis. / 08.2014 / PubMed / Full text
Concentrated fish oil (Lovaza(R)) extends lifespan and attenuates kidney disease in lupus-prone short-lived (NZBxNZW)F1 mice. / 06.2013 / PubMed / Full text
Soluble ecto-5'-nucleotidase (5'-NT), alkaline phosphatase, and adenosine deaminase (ADA1) activities in neonatal blood favor elevated extracellular adenosine. / 20.09.2013 / PubMed / Full text
Aging affects AO rat splenic conventional dendritic cell subset composition, cytokine synthesis and T-helper polarizing capacity. / 08.2013 / PubMed / Full text
Senescent endothelial cells are prone to TNF-α-induced cell death due to expression of FAS receptor. / 23.08.2013 / PubMed / Full text
Age-related CD4( )CD25( )Foxp3( ) regulatory T-cell responses during Plasmodium berghei ANKA infection in mice susceptible or resistant to cerebral malaria. / 06.2013 / PubMed / Full text
[The relationship between the polymorphism of immunity genes and both aging and age-related diseases]. / 07.2013 / PubMed / Full text
The influence of aging and estradiol to progesterone ratio on rat macrophage phenotypic profile and NO and TNF-α production. / 11.2013 / PubMed / Full text
Proinflammatory cytokines, aging, and age-related diseases. / 12.2013 / PubMed / Full text
Brief report: deficient thymic output in rheumatoid arthritis despite abundance of prethymic progenitors. / 10.2013 / PubMed / Full text
Chronic low dose tumor necrosis factor-α (TNF) suppresses early bone accrual in young mice by inhibiting osteoblasts without affecting osteoclasts. / 09.2013 / PubMed / Full text
Calcium dysregulation and neuroinflammation: discrete and integrated mechanisms for age-related synaptic dysfunction. / 09.2013 / PubMed / Full text
Expression of angiotensin II and its receptors in activated microglia in experimentally induced cerebral ischemia in the adult rats. / 10.2013 / PubMed / Full text
Aging and airway inflammation. / 06.2013 / PubMed / Full text
A Jerte valley cherry product provides beneficial effects on sleep quality. Influence on aging. / 2013 / PubMed / Full text
Effects of ethanol on immune response in the brain: region-specific changes in aged mice. / 23.05.2013 / PubMed / Full text
Heightened muscle inflammation susceptibility may impair regenerative capacity in aging humans. / 09.2013 / PubMed / Full text
Angiopoietin-like 2 promotes atherogenesis in mice. / 10.05.2013 / PubMed / Full text
The functional tumor necrosis factor-α (308A/G) polymorphism modulates attentional selection in elderly individuals. / 11.2013 / PubMed / Full text
Parasitological and immunological aspects of early Ascaris spp. infection in mice. / 08.2013 / PubMed / Full text
Neurogenic factor-induced Langerhans cell activation in diabetic mice with mechanical allodynia. / 14.05.2013 / PubMed / Full text
The roles of immune memory and aging in protective immunity and endogenous reactivation of tuberculosis. / 2013 / PubMed / Full text
Chronic neuron- and age-selective down-regulation of TNF receptor expression in triple-transgenic Alzheimer disease mice leads to significant modulation of amyloid- and Tau-related pathologies. / 06.2013 / PubMed / Full text
Ageing impairs the T cell response to dendritic cells. / 08.2013 / PubMed / Full text
Aging accentuates alcohol-induced decrease in protein synthesis in gastrocnemius. / 15.05.2013 / PubMed / Full text
Propolis efficacy on TNF-α, IFN-γ and IL2 cytokines production in old mice with and without systemic candidiasis. / 09.2012 / PubMed / Full text
Active muscle regeneration following eccentric contraction-induced injury is similar between healthy young and older adults. / 01.06.2014 / PubMed / Full text
Maternal immune activation leads to age-related behavioral and immunological changes in male rat offspring - the effect of antipsychotic drugs. / 2012 / PubMed / Full text
TNF-α, IL6, and IL10 polymorphisms and the effect of physical exercise on inflammatory parameters and physical performance in elderly women. / 12.2013 / PubMed / Full text
Blood CD33( )HLA-DR(-) myeloid-derived suppressor cells are increased with age and a history of cancer. / 04.2013 / PubMed / Full text
Sarcopenia and mortality risk in frail older persons aged 80 years and older: results from ilSIRENTE study. / 03.2013 / PubMed / Full text
Maintenance of CMV-specific CD8 T cell responses and the relationship of IL-27 to IFN-γ levels with aging. / 02.2013 / PubMed / Full text
Minocycline mitigates isoflurane-induced cognitive impairment in aged rats. / 16.02.2013 / PubMed / Full text
Relationships between body condition score and plasma inflammatory cytokines, insulin, and lipids in a mixed population of light-breed horses. / 01-02.2013 / PubMed / Full text
Age-related changes in intracellular expression of IFN-γ and TNF-α in equine lymphocytes measured in bronchoalveolar lavage and peripheral blood. / 03.2013 / PubMed / Full text

SIRT1[править]

SIRT1 - a new mammalian substrate of nuclear autophagy. / 08.12.2020 / PubMed / Full text
The Aging Stress Response and Its Implication for AMD Pathogenesis. / 22.11.2020 / PubMed / Full text
Anthocyanins attenuate endothelial dysfunction through regulation of uncoupling of nitric oxide synthase in aged rats. / 03.12.2020 / PubMed / Full text
Sirtuins and Their Implications in Neurodegenerative Diseases from a Drug Discovery Perspective. / 05.12.2020 / PubMed / Full text
Naringenin alleviates nonalcoholic steatohepatitis in middle-aged Apoe mice: role of SIRT1. / 18.11.2020 / PubMed / Full text
Effects of alpha-mangostin on memory senescence induced by high glucose in human umbilical vein endothelial cells. / 10.2020 / PubMed / Full text
Melatonin and Sirtuins in Buccal Epithelium: Potential Biomarkers of Aging and Age-Related Pathologies. / 30.10.2020 / PubMed / Full text
SIRT1 Activation Using CRISPR/dCas9 Promotes Regeneration of Human Corneal Endothelial Cells through Inhibiting Senescence. / 04.11.2020 / PubMed / Full text
Histone Deacetylase SIRT1, Smooth Muscle Cell Function, and Vascular Diseases. / 2020 / PubMed / Full text
6,4'-dihydroxy-7-methoxyflavanone protects against H O -induced cellular senescence by inducing SIRT1 and inhibiting phosphatidylinositol 3-kinase/Akt pathway activation. / 27.10.2020 / PubMed / Full text
Sirtuins as Possible Predictors of Aging and Alzheimer's Disease Development: Verification in the Hippocampus and Saliva. / 10.2020 / PubMed / Full text
FGFR4 Inhibitor BLU9931 Attenuates Pancreatic Cancer Cell Proliferation and Invasion While Inducing Senescence: Evidence for Senolytic Therapy Potential in Pancreatic Cancer. / 14.10.2020 / PubMed / Full text
A comparative study on the cellular stressors in mesenchymal stem cells (MSCs) and pancreatic β-cells under hyperglycemic milieu. / 30.09.2020 / PubMed / Full text
[i]Citrus hystrix[/i] Extracts Protect Human Neuronal Cells against High Glucose-Induced Senescence. / 30.09.2020 / PubMed / Full text
Isoparvifuran isolated from Dalbergia odorifera attenuates H O -induced senescence of BJ cells through SIRT1 activation and AKT/mTOR pathway inhibition. / 30.09.2020 / PubMed / Full text
SIRT1 Is the Target Gene for 2,3,5,4'-Tetrahydroxystilbene-2-O-β-D-Glucoside Alleviating the HUVEC Senescence. / 2020 / PubMed / Full text
Re-equilibration of imbalanced NAD metabolism ameliorates the impact of telomere dysfunction. / 02.11.2020 / PubMed / Full text
The Role of Sirtuins in Kidney Diseases. / 12.09.2020 / PubMed / Full text
The effect of 12-week resistance exercise training on serum levels of cellular aging process parameters in elderly men. / 11.2020 / PubMed / Full text
Senescence and autophagy in usual interstitial pneumonia of different etiology. / 27.08.2020 / PubMed / Full text
Virus-Induced Asthma Exacerbations: SIRT1 Targeted Approach. / 13.08.2020 / PubMed / Full text
Novel resveratrol derivatives have diverse effects on the survival, proliferation and senescence of primary human fibroblasts. / 12.2020 / PubMed / Full text
Glucose restriction delays senescence and promotes proliferation of HUVECs via the AMPK/SIRT1-FOXA3-Beclin1 pathway. / 01.10.2020 / PubMed / Full text
Ginsenoside Rg1 protects against Sca-1 HSC/HPC cell aging by regulating the SIRT1-FOXO3 and SIRT3-SOD2 signaling pathways in a γ-ray irradiation-induced aging mice model. / 08.2020 / PubMed / Full text
Therapeutic Effects of SRT2104 on Lung Injury in Rats with Emphysema via Reduction of Type II Alveolar Epithelial Cell Senescence. / 08.2020 / PubMed / Full text
Quercetin alleviates kidney fibrosis by reducing renal tubular epithelial cell senescence through the SIRT1/PINK1/mitophagy axis. / 15.09.2020 / PubMed / Full text
SIRT1 alleviates high-magnitude compression-induced senescence in nucleus pulposus cells via PINK1-dependent mitophagy. / 18.07.2020 / PubMed / Full text
Survival analyses in Holstein cows considering direct disease diagnoses and specific SNP marker effects. / 09.2020 / PubMed / Full text
Material basis, effect, and mechanism of ethanol extract of Pinellia ternata tubers on oxidative stress-induced cell senescence. / 10.2020 / PubMed / Full text
Inhibition of miR-34a reduces cellular senescence in human adipose tissue-derived mesenchymal stem cells through the activation of SIRT1. / 15.09.2020 / PubMed / Full text
Transcriptome analysis of common and diverged circulating miRNAs between arterial and venous during aging. / 30.06.2020 / PubMed / Full text
Activation of FoxO1/SIRT1/RANKL/OPG pathway may underlie the therapeutic effects of resveratrol on aging-dependent male osteoporosis. / 12.06.2020 / PubMed / Full text
Latifolin Inhibits Oxidative Stress-Induced Senescence via Upregulation of SIRT1 in Human Dermal Fibroblasts. / 01.07.2020 / PubMed / Full text
Metabolite Profiling of Rambutan ([i]Nephelium lappaceum[/i] L.) Seeds Using UPLC-qTOF-MS/MS and Senomorphic Effects in Aged Human Dermal Fibroblasts. / 15.05.2020 / PubMed / Full text
SRT1720-induced activation of SIRT1 alleviates vascular smooth muscle cell senescence through PKA-dependent phosphorylation of AMPKα at Ser485. / 07.2020 / PubMed / Full text
Circadian rhythm disruption and Alzheimer's disease: The dynamics of a vicious cycle. / 28.04.2020 / PubMed / Full text
miR-128 plays a critical role in murine osteoclastogenesis and estrogen deficiency-induced bone loss. / 2020 / PubMed / Full text
Lymphocyte senescence in COPD is associated with decreased sirtuin 1 expression in steroid resistant pro-inflammatory lymphocytes. / 01-12.2020 / PubMed / Full text
Therapeutic effects of hydro-alcoholic leaf extract of Withania somnifera on age-induced changes in daily rhythms of Sirt1, Nrf2 and Rev-erbα in the SCN of male Wistar rats. / 10.2020 / PubMed / Full text
Dipeptidyl peptidase-4 inhibition improves endothelial senescence by activating AMPK/SIRT1/Nrf2 signaling pathway. / 07.2020 / PubMed / Full text
The Serum Concentration of Anti-Aging Proteins, Sirtuin1 and αKlotho in Patients with End-Stage Kidney Disease on Maintenance Hemodialysis. / 2020 / PubMed / Full text
Small extracellular vesicles deliver miR-21 and miR-217 as pro-senescence effectors to endothelial cells. / 2020 / PubMed / Full text
Spatiotemporal gating of SIRT1 functions by O-GlcNAcylation is essential for liver metabolic switching and prevents hyperglycemia. / 24.03.2020 / PubMed / Full text
Hydrogen Sulfide Inhibits Homocysteine-Induced Neuronal Senescence by Up-Regulation of SIRT1. / 2020 / PubMed / Full text
SIRT1 and aging related signaling pathways. / 04.2020 / PubMed / Full text
Tropisetron protects against brain aging via attenuating oxidative stress, apoptosis and inflammation: The role of SIRT1 signaling. / 01.05.2020 / PubMed / Full text
Nicotinamide mononucleotide (NMN) supplementation promotes neurovascular rejuvenation in aged mice: transcriptional footprint of SIRT1 activation, mitochondrial protection, anti-inflammatory, and anti-apoptotic effects. / 04.2020 / PubMed / Full text
The Citrus Flavonoid Naringenin Protects the Myocardium from Ageing-Dependent Dysfunction: Potential Role of SIRT1. / 2020 / PubMed / Full text
Deacetylation of MRTF-A by SIRT1 defies senescence induced down-regulation of collagen type I in fibroblast cells. / 01.05.2020 / PubMed / Full text
Chronic Polyphenon-60 or Catechin Treatments Increase Brain Monoamines Syntheses and Hippocampal SIRT1 Levels Improving Cognition in Aged Rats. / 26.01.2020 / PubMed / Full text
Context-Dependent Roles for SIRT2 and SIRT3 in Tumor Development Upon Calorie Restriction or High Fat Diet. / 2019 / PubMed / Full text
Duck Oil-loaded Nanoemulsion Inhibits Senescence of Angiotensin II-treated Vascular Smooth Muscle Cells by Upregulating SIRT1. / 01.2020 / PubMed / Full text
Two novel SIRT1 activators, SCIC2 and SCIC2.1, enhance SIRT1-mediated effects in stress response and senescence. / 06-07.2020 / PubMed / Full text
Hydrogen sulfide attenuates mitochondrial dysfunction-induced cellular senescence and apoptosis in alveolar epithelial cells by upregulating sirtuin 1. / 23.12.2019 / PubMed / Full text
The protective role of omentin-1 in IL-1β-induced chondrocyte senescence. / 12.2020 / PubMed / Full text
The Lifespan Extension Ability of Nicotinic Acid Depends on Whether the Intracellular NAD Level Is Lower than the Sirtuin-Saturating Concentrations. / 24.12.2019 / PubMed / Full text
Alpha-mangostin decreased cellular senescence in human umbilical vein endothelial cells. / 06.2020 / PubMed / Full text
Central nervous system SIRT1 expression is required for cued and contextual fear conditioning memory responses in aging mice. / 23.09.2019 / PubMed / Full text
Does education level protect us from rapid ageing? Sirtuin expression versus age and level of education. / 10.2019 / PubMed
CO ameliorates endothelial senescence induced by 5-fluorouracil through SIRT1 activation. / 30.11.2019 / PubMed / Full text
Long noncoding RNA GAS5 inhibits cell proliferation and fibrosis in diabetic nephropathy by sponging miR-221 and modulating SIRT1 expression. / 20.10.2019 / PubMed / Full text
NLRP3 inflammasome suppression improves longevity and prevents cardiac aging in male mice. / 01.2020 / PubMed / Full text
The Role of Sirtuin1 in Regulating Endothelial Function, Arterial Remodeling and Vascular Aging. / 2019 / PubMed / Full text
Deacetylation of LAMP1 drives lipophagy-dependent generation of free fatty acids by Abrus agglutinin to promote senescence in prostate cancer. / 03.2020 / PubMed / Full text
Plasma exosomes in OSA patients promote endothelial senescence: effect of long-term adherent continuous positive airway pressure. / 13.02.2020 / PubMed / Full text
Metabolism and biochemical properties of nicotinamide adenine dinucleotide (NAD) analogs, nicotinamide guanine dinucleotide (NGD) and nicotinamide hypoxanthine dinucleotide (NHD). / 11.09.2019 / PubMed / Full text
Hydrogen Sulfide Inhibits High Glucose-Induced Neuronal Senescence by Improving Autophagic Flux [i]via[/i] Up-regulation of SIRT1. / 2019 / PubMed / Full text
MicroRNA-34a (miR-34a) Mediates Retinal Endothelial Cell Premature Senescence through Mitochondrial Dysfunction and Loss of Antioxidant Activities. / 22.08.2019 / PubMed / Full text
Activation of the miR-34a-Mediated SIRT1/mTOR Signaling Pathway by Urolithin A Attenuates D-Galactose-Induced Brain Aging in Mice. / 10.2019 / PubMed / Full text
[Ginsenoside Rg_1 induces leukemia stem cell senescence via SIRT1/TSC_2 signal axis]. / 06.2019 / PubMed / Full text
miR-23b-3p regulates apoptosis and autophagy via suppressing SIRT1 in lens epithelial cells. / 12.2019 / PubMed / Full text
Genetic background, epigenetic factors and dietary interventions which influence human longevity. / 10.2019 / PubMed / Full text
Adipose-Derived Stem/Stromal Cells Recapitulate Aging Biomarkers and Show Reduced Stem Cell Plasticity Affecting Their Adipogenic Differentiation Capacity. / 08.2019 / PubMed / Full text
Interference with the bromodomain epigenome readers drives p21 expression and tumor senescence. / 01.10.2019 / PubMed / Full text
Involvement of [i]microRNA-34a[/i] in Age-Related Susceptibility to Oxidative Stress in ARPE-19 Cells by Targeting the Silent Mating Type Information Regulation 2 Homolog 1/p66shc Pathway: Implications for Age-Related Macular Degeneration. / 2019 / PubMed / Full text
GPR39 agonist TC-G 1008 ameliorates IL-1β-induced chondrocyte senescence. / 12.2019 / PubMed / Full text
Rational design of novel sirtuin 1 activators via structure-activity insights from application of QSAR modeling. / 2019 / PubMed / Full text
Metformin prevents murine ovarian aging. / 10.06.2019 / PubMed / Full text
Time-restricted feeding delays the emergence of the age-associated, neoplastic-prone tissue landscape. / 12.06.2019 / PubMed / Full text
Myocyte enhancer factor 2A delays vascular endothelial cell senescence by activating the PI3K/p-Akt/SIRT1 pathway. / 10.06.2019 / PubMed / Full text
SIRT1 protects cochlear hair cell and delays age-related hearing loss via autophagy. / 08.2019 / PubMed / Full text
Transcriptome analysis revealed potential mechanisms of differences in physiological stress responses between caged male and female magpies. / 03.06.2019 / PubMed / Full text
Nicotinamide mononucleotide (NMN) treatment attenuates oxidative stress and rescues angiogenic capacity in aged cerebromicrovascular endothelial cells: a potential mechanism for the prevention of vascular cognitive impairment. / 10.2019 / PubMed / Full text
Molecular docking analysis of imine stilbene analogs and evaluation of their anti-aging activity using yeast and mammalian cell models. / 02.2019 / PubMed / Full text
Molecular and Cellular Characterization of SIRT1 Allosteric Activators. / 2019 / PubMed / Full text
Total flavonoids from the Carya cathayensis Sarg. leaves inhibit HUVEC senescence through the miR-34a/SIRT1 pathway. / 10.2019 / PubMed / Full text
Impaired SIRT1 activity leads to diminution in glomerular endowment without accelerating age-associated GFR decline. / 05.2019 / PubMed / Full text
Estrogen-SIRT1 Axis Plays a Pivotal Role in Protecting Arteries Against Menopause-Induced Senescence and Atherosclerosis. / 01.01.2020 / PubMed / Full text
Spatio-temporal expression profile of sirtuins during aging of the annual fish Nothobranchius furzeri. / 09.2019 / PubMed / Full text
Protective effect of vildagliptin on TNF-α-induced chondrocyte senescence. / 07.2019 / PubMed / Full text
Polymorphism rs7895833 in the SIRT1 gene and its association with dyslipidaemia in the elderly. / 07-08.2019 / PubMed / Full text
Modulation of miR-34a/SIRT1 signaling protects cochlear hair cells against oxidative stress and delays age-related hearing loss through coordinated regulation of mitophagy and mitochondrial biogenesis. / 07.2019 / PubMed / Full text
Nicotinamide mononucleotide promotes osteogenesis and reduces adipogenesis by regulating mesenchymal stromal cells via the SIRT1 pathway in aged bone marrow. / 18.04.2019 / PubMed / Full text
Cordycepin, an Active Constituent of Nutrient Powerhouse and Potential Medicinal Mushroom [i]Cordyceps militaris[/i] Linn., Ameliorates Age-Related Testicular Dysfunction in Rats. / 23.04.2019 / PubMed / Full text
The resistant effect of SIRT1 in oxidative stress-induced senescence of rat nucleus pulposus cell is regulated by Akt-FoxO1 pathway. / 31.05.2019 / PubMed / Full text
Photobiomodulation and Coenzyme Q Treatments Attenuate Cognitive Impairment Associated With Model of Transient Global Brain Ischemia in Artificially Aged Mice. / 2019 / PubMed / Full text
The role of SIRT1 in neuroinflammation and cognitive dysfunction in aged rats after anesthesia and surgery. / 2019 / PubMed / Full text
NAD supplementation rejuvenates aged gut adult stem cells. / 06.2019 / PubMed / Full text
NMNAT2-mediated NAD generation is essential for quality control of aged oocytes. / 06.2019 / PubMed / Full text
Mitochondrial dysfunction in neurodegenerative diseases and the potential countermeasure. / 07.2019 / PubMed / Full text
Drugs targeting SIRT1, a new generation of therapeutics for osteoporosis and other bone related disorders? / 05.2019 / PubMed / Full text
Aging, Melatonin, and the Pro- and Anti-Inflammatory Networks. / 11.03.2019 / PubMed / Full text
Knockout of receptor for advanced glycation end-products attenuates age-related renal lesions. / 04.2019 / PubMed / Full text
Stress-induced precocious aging in PD-patient iPSC-derived NSCs may underlie the pathophysiology of Parkinson's disease. / 04.02.2019 / PubMed / Full text
Bone Marrow Mesenchymal Stem Cells-Derived Exosomal MiR-29b-3p Regulates Aging-Associated Insulin Resistance. / 26.02.2019 / PubMed / Full text
Strength training and aerobic exercise alter mitochondrial parameters in brown adipose tissue and equally reduce body adiposity in aged rats. / 02.2019 / PubMed / Full text
Novel biomolecules of ageing, sex differences and potential underlying mechanisms of telomere shortening in coronary artery disease. / 05.2019 / PubMed / Full text
Generation of a novel model of primary human cell senescence through Tenovin-6 mediated inhibition of sirtuins. / 06.2019 / PubMed / Full text
Budesonide, Aclidinium and Formoterol in combination limit inflammaging processes in bronchial epithelial cells exposed to cigarette smoke. / 04.2019 / PubMed / Full text
Relationship between senescence in macaques and bone marrow mesenchymal stem cells and the molecular mechanism. / 23.01.2019 / PubMed / Full text
Protective Role of Endogenous Kallistatin in Vascular Injury and Senescence by Inhibiting Oxidative Stress and Inflammation. / 2018 / PubMed / Full text
NKT-like cells reveal higher than T lymphocytes expression of cellular protective proteins HSP70 and SOD2 and comparably increased expression of SIRT1 in the oldest seniors. / 2018 / PubMed / Full text
Melatonin regulates the activities of ovary and delays the fertility decline in female animals via MT1/AMPK pathway. / 04.2019 / PubMed / Full text
Exercise training augments Sirt1-signaling and attenuates cardiac inflammation in D-galactose induced-aging rats. / 23.12.2018 / PubMed / Full text
Establishment of a Mouse Model of Premature Ovarian Failure Using Consecutive Superovulation. / 2018 / PubMed / Full text
Diesel exhaust exposure intensifies inflammatory and structural changes associated with lung aging in mice. / 15.04.2019 / PubMed / Full text
CD56bright cells respond to stimulation until very advanced age revealing increased expression of cellular protective proteins SIRT1, HSP70 and SOD2. / 2018 / PubMed / Full text
Amentoflavone Induces Autophagy and Modulates p53. / 04.2019 / PubMed / Full text
Induction of a senescent like phenotype and loss of gap junctional intercellular communication by carbon nanoparticle exposure of lung epithelial cells. / 03.2019 / PubMed / Full text
Sirtuins: Developing Innovative Treatments for Aged-Related Memory Loss and Alzheimer's Disease. / 2018 / PubMed / Full text
N-acetylcysteine ameliorates cisplatin-induced renal senescence and renal interstitial fibrosis through sirtuin1 activation and p53 deacetylation. / 01.2019 / PubMed / Full text
Comparing the Effects of Low-Protein and High-Carbohydrate Diets and Caloric Restriction on Brain Aging in Mice. / 20.11.2018 / PubMed / Full text
Metformin Is a Direct SIRT1-Activating Compound: Computational Modeling and Experimental Validation. / 2018 / PubMed / Full text
Hsp90 Stabilizes SIRT1 Orthologs in Mammalian Cells and [i]C. elegans[/i]. / 20.11.2018 / PubMed / Full text
Sirtuins and NAD in the Development and Treatment of Metabolic and Cardiovascular Diseases. / 14.09.2018 / PubMed / Full text
SIRT1 deacetylase in aging-induced neuromuscular degeneration and amyotrophic lateral sclerosis. / 12.2018 / PubMed / Full text
Prevention of Senescence in Vasculature Through Quiescence. / 10.2018 / PubMed / Full text
Melatonin and inflammation-Story of a double-edged blade. / 11.2018 / PubMed / Full text
ALDH2 mediates the dose-response protection of chronic ethanol against endothelial senescence through SIRT1/p53 pathway. / 12.10.2018 / PubMed / Full text
Resveratrol-loaded nanoemulsion prevents cognitive decline after abdominal surgery in aged rats. / 08.2018 / PubMed / Full text
Endothelial SIRT1 prevents age-induced impairment of vasodilator responses by enhancing the expression and activity of soluble guanylyl cyclase in smooth muscle cells. / 01.03.2019 / PubMed / Full text
Effects of Ginsenoside Rg3 on fatigue resistance and SIRT1 in aged rats. / 01.11.2018 / PubMed / Full text
PARP1 inhibitor (PJ34) improves the function of aging-induced endothelial progenitor cells by preserving intracellular NAD levels and increasing SIRT1 activity. / 23.08.2018 / PubMed / Full text
Moderate calorie restriction attenuates age‑associated alterations and improves cardiac function by increasing SIRT1 and SIRT3 expression. / 10.2018 / PubMed / Full text
Liver regeneration in aged mice: new insights. / 28.08.2018 / PubMed / Full text
Phenolic Plant Extracts Induce Sirt1 Activity and Increase Antioxidant Levels in the Rabbit's Heart and Liver. / 2018 / PubMed / Full text
Defect of SIRT1-FoxO3a axis is associated with the production of reactive oxygen species during protein kinase CK2 downregulation-mediated cellular senescence and nematode aging. / 04.2019 / PubMed / Full text
Master athletes have higher miR-7, SIRT3 and SOD2 expression in skeletal muscle than age-matched sedentary controls. / 10.2018 / PubMed / Full text
Tenovin-1 Induces Senescence and Decreases Wound-Healing Activity in Cultured Rat Primary Astrocytes. / 01.05.2019 / PubMed / Full text
PGC-1α Protects RPE Cells of the Aging Retina against Oxidative Stress-Induced Degeneration through the Regulation of Senescence and Mitochondrial Quality Control. The Significance for AMD Pathogenesis. / 07.08.2018 / PubMed / Full text
Effect of oral appliance on circulating leukocyte telomere length and SIRT1 in obstructive sleep apnea. / 03.2019 / PubMed / Full text
miR-34a Promotes Vascular Smooth Muscle Cell Calcification by Downregulating SIRT1 (Sirtuin 1) and Axl (AXL Receptor Tyrosine Kinase). / 09.2018 / PubMed / Full text
A SIRT1-centered circuitry regulates breast cancer stemness and metastasis. / 12.2018 / PubMed / Full text
Apelin/APJ axis improves angiotensin II-induced endothelial cell senescence through AMPK/SIRT1 signaling pathway. / 06.2018 / PubMed / Full text
Sirtuin 1 and Alzheimer's disease: An up-to-date review. / 10.2018 / PubMed / Full text
CCAR-1 is a negative regulator of the heat-shock response in Caenorhabditis elegans. / 10.2018 / PubMed / Full text
Kallistatin attenuates endothelial senescence by modulating Let-7g-mediated miR-34a-SIRT1-eNOS pathway. / 09.2018 / PubMed / Full text
Serum containing Buyang Huanwu decoction prevents age-associated migration and invasion of human vascular smooth muscle cells by up regulating SIRT1 expression. / 17.07.2018 / PubMed / Full text
Role of accelerated aging in limb muscle wasting of patients with COPD. / 2018 / PubMed / Full text
Resveratrol promotes oxidative stress to drive DLC1 mediated cellular senescence in cancer cells. / 15.09.2018 / PubMed / Full text
Mesenchymal stem cells confer resistance to doxorubicin-induced cardiac senescence by inhibiting microRNA-34a. / 06.2018 / PubMed / Full text
The circadian clock in adult neural stem cell maintenance. / 02.2019 / PubMed / Full text
Resveratrol reduces senescence-associated secretory phenotype by SIRT1/NF-κB pathway in gut of the annual fish Nothobranchius guentheri. / 09.2018 / PubMed / Full text
Loss of NAMPT in aging retinal pigment epithelium reduces NAD availability and promotes cellular senescence. / 12.06.2018 / PubMed / Full text
Mushroom extract inhibits ultraviolet B-induced cellular senescence in human keratinocytes. / 06.2018 / PubMed / Full text
SIRT1, miR-132 and miR-212 link human longevity to Alzheimer's Disease. / 31.05.2018 / PubMed / Full text
Endothelial progenitor cells from aged subjects display decreased expression of sirtuin 1, angiogenic functions, and increased senescence. / 09.2018 / PubMed / Full text
Rejuvenating Aged Hematopoietic Stem Cells Through Improvement of Mitochondrial Function. / 09.2018 / PubMed / Full text
Berberine Improves Cognitive Deficiency and Muscular Dysfunction via Activation of the AMPK/SIRT1/PGC-1a Pathway in Skeletal Muscle from Naturally Aging Rats. / 2018 / PubMed / Full text
SIRT1 reverses senescence via enhancing autophagy and attenuates oxidative stress-induced apoptosis through promoting p53 degradation. / 01.10.2018 / PubMed / Full text
Loss of sirtuin 1 and mitofusin 2 contributes to enhanced ischemia/reperfusion injury in aged livers. / 08.2018 / PubMed / Full text
Dietary polyphenols and neurogenesis: Molecular interactions and implication for brain ageing and cognition. / 07.2018 / PubMed / Full text
Whey Protein Attenuates Angiotensin II-Primed Premature Senescence of Vascular Smooth Muscle Cells through Upregulation of SIRT1. / 2017 / PubMed / Full text
Role of hypothalamus in aging and its underlying cellular mechanisms. / 01.2019 / PubMed / Full text
The variable role of SIRT1 in the maintenance and differentiation of mesenchymal stem cells. / 04.2018 / PubMed / Full text
Sirtuins in Renal Health and Disease. / 07.2018 / PubMed / Full text
Physical Exercise Improves Aging-Related Changes in Angiotensin, IGF-1, SIRT1, SIRT3, and VEGF in the Substantia Nigra. / 10.11.2018 / PubMed / Full text
MeCP2-mediated epigenetic regulation in senescent endothelial progenitor cells. / 03.04.2018 / PubMed / Full text
Natural products with anti-aging potential: Affected targets and molecular mechanisms. / 01.11.2018 / PubMed / Full text
[Effect of microRNA-34a/SIRT1/p53 signal pathway on notoginsenoside R₁ delaying vascular endothelial cell senescence]. / 02.2018 / PubMed / Full text
SIRT1 and microRNAs: The role in breast, lung and prostate cancers. / 01.06.2018 / PubMed / Full text
Leukotriene D4 induces cellular senescence in osteoblasts. / 05.2018 / PubMed / Full text
Impairment of an Endothelial NAD -H S Signaling Network Is a Reversible Cause of Vascular Aging. / 22.03.2018 / PubMed / Full text
Differential gene expression of sirtuins between somatotropinomas and nonfunctioning pituitary adenomas. / 08.2018 / PubMed / Full text
Nicotinamide Improves Aspects of Healthspan, but Not Lifespan, in Mice. / 06.03.2018 / PubMed / Full text
Role of Sirtuin1-p53 regulatory axis in aging, cancer and cellular reprogramming. / 05.2018 / PubMed / Full text
HGF and BFGF Secretion by Human Adipose-Derived Stem Cells Improves Ovarian Function During Natural Aging via Activation of the SIRT1/FOXO1 Signaling Pathway. / 2018 / PubMed / Full text
The protective effect of resveratrol on vascular aging by modulation of the renin-angiotensin system. / 03.2018 / PubMed / Full text
Metformin regulates mitochondrial biogenesis and senescence through AMPK mediated H3K79 methylation: Relevance in age-associated vascular dysfunction. / 04.2018 / PubMed / Full text
Antagonism of cysteinyl leukotriene receptor 1 (cysLTR1) by montelukast suppresses cell senescence of chondrocytes. / 03.2018 / PubMed / Full text
Gut flora-dependent metabolite Trimethylamine-N-oxide accelerates endothelial cell senescence and vascular aging through oxidative stress. / 20.02.2018 / PubMed / Full text
Resveratrol, an Nrf2 activator, ameliorates aging-related progressive renal injury. / 11.01.2018 / PubMed / Full text
Acetylshikonin from Zicao attenuates cognitive impairment and hippocampus senescence in d-galactose-induced aging mouse model via upregulating the expression of SIRT1. / 03.2018 / PubMed / Full text
Dexamethasone downregulates SIRT1 and IL6 and upregulates EDN1 genes in stem cells derived from gingivae via the AGE/RAGE pathway. / 03.2018 / PubMed / Full text
Sirtuins in Brain Aging and Neurological Disorders. / 2017 / PubMed / Full text
[Aging-related change of erectile function and the expression of SIRT1]. / 12.2016 / PubMed
Expression of Sirtuins in the Retinal Neurons of Mice, Rats, and Humans. / 2017 / PubMed / Full text
Maternal aging affects oocyte resilience to carbonyl cyanide-m-chlorophenylhydrazone -induced mitochondrial dysfunction in cows. / 2017 / PubMed / Full text
Nicotinamide phosphoribosyltransferase delays cellular senescence by upregulating SIRT1 activity and antioxidant gene expression in mouse cells. / 12.2017 / PubMed / Full text
Stem Cells and Progenitors in Human Peripheral Blood Get Activated by Extremely Active Resveratrol (XAR™). / 04.2018 / PubMed / Full text
Fibroblast growth factor 21 delayed endothelial replicative senescence and protected cells from H O -induced premature senescence through SIRT1. / 2017 / PubMed / Full text
Tucum-do-Cerrado (Bactris setosa Mart.) May Promote Anti-Aging Effect by Upregulating SIRT1-Nrf2 Pathway and Attenuating Oxidative Stress and Inflammation. / 14.11.2017 / PubMed / Full text
Maternal high calorie diet induces mitochondrial dysfunction and senescence phenotype in subcutaneous fat of newborn mice. / 13.10.2017 / PubMed / Full text
O-GlcNAcylation of SIRT1 enhances its deacetylase activity and promotes cytoprotection under stress. / 14.11.2017 / PubMed / Full text
Aging as an Epigenetic Phenomenon. / 10.2017 / PubMed / Full text
MeCP2 mediated dysfunction in senescent EPCs. / 03.10.2017 / PubMed / Full text
Role of Beta-adrenergic Receptors and Sirtuin Signaling in the Heart During Aging, Heart Failure, and Adaptation to Stress. / 01.2018 / PubMed / Full text
A comparative study of anti-aging properties and mechanism: resveratrol and caloric restriction. / 12.09.2017 / PubMed / Full text
Small molecule modulation of splicing factor expression is associated with rescue from cellular senescence. / 17.10.2017 / PubMed / Full text
Negative regulation of Sirtuin 1 by AMP-activated protein kinase promotes metformin-induced senescence in hepatocellular carcinoma xenografts. / 28.12.2017 / PubMed / Full text
Blocking SIRT1 inhibits cell proliferation and promotes aging through the PI3K/AKT pathway. / 01.12.2017 / PubMed / Full text
SIRT1 is a positive regulator of in vivo bone mass and a therapeutic target for osteoporosis. / 2017 / PubMed / Full text
[Protective effect of total saponins of Panax notoginseng combined with total flavonoids of epimedium on D-galactose-incuced senescence of H9c2 cell]. / 02.2017 / PubMed / Full text
SIRT1 is a transcriptional enhancer of the glucocorticoid receptor acting independently to its deacetylase activity. / 05.02.2018 / PubMed / Full text
G protein-coupled receptor kinase 4-induced cellular senescence and its senescence-associated gene expression profiling. / 15.11.2017 / PubMed / Full text
The effect of exercise, resveratrol or their combination on Sarcopenia in aged rats via regulation of AMPK/Sirt1 pathway. / 11.2017 / PubMed / Full text
Chronic Silymarin, Quercetin and Naringenin Treatments Increase Monoamines Synthesis and Hippocampal Sirt1 Levels Improving Cognition in Aged Rats. / 03.2018 / PubMed / Full text
Aquatide Activation of SIRT1 Reduces Cellular Senescence through a SIRT1-FOXO1-Autophagy Axis. / 01.09.2017 / PubMed / Full text
Obesity and aging diminish sirtuin 1 (SIRT1)-mediated deacetylation of SIRT3, leading to hyperacetylation and decreased activity and stability of SIRT3. / 20.10.2017 / PubMed / Full text
Circadian Reprogramming in the Liver Identifies Metabolic Pathways of Aging. / 10.08.2017 / PubMed / Full text
High glucose and free fatty acids induce endothelial progenitor cell senescence via PGC-1α/SIRT1 signaling pathway. / 10.2017 / PubMed / Full text
Molecular evolutionary patterns of NAD /Sirtuin aging signaling pathway across taxa. / 2017 / PubMed / Full text
Comparing the Effects of Melatonin with Caloric Restriction in the Hippocampus of Aging Mice: Involvement of Sirtuin1 and the FOXOs Pathway. / 01.2018 / PubMed / Full text
Role of Kallistatin Treatment in Aging and Cancer by Modulating miR-34a and miR-21 Expression. / 2017 / PubMed / Full text
Inflammation, Stem Cells, and the Aging Hypothalamus. / 08.2017 / PubMed / Full text
Myricetin improves endurance capacity and mitochondrial density by activating SIRT1 and PGC-1α. / 24.07.2017 / PubMed / Full text
Moving to the Rhythm with Clock (Circadian) Genes, Autophagy, mTOR, and SIRT1 in Degenerative Disease and Cancer. / 2017 / PubMed / Full text
The emerging role of alternative splicing in senescence and aging. / 10.2017 / PubMed / Full text
miR-34a and miR-9 are overexpressed and SIRT genes are downregulated in peripheral blood mononuclear cells of aging humans. / 08.2017 / PubMed / Full text
Regulation of SIRT1/AMPK axis is critically involved in gallotannin-induced senescence and impaired autophagy leading to cell death in hepatocellular carcinoma cells. / 01.2018 / PubMed / Full text
SIRT1 and SIRT6 Signaling Pathways in Cardiovascular Disease Protection. / 10.03.2018 / PubMed / Full text
Effects of Resveratrol and other Polyphenols on Sirt1: Relevance to Brain Function During Aging. / 30.01.2018 / PubMed / Full text
Reduction in podocyte SIRT1 accelerates kidney injury in aging mice. / 01.09.2017 / PubMed / Full text
Effects of resveratrol, curcumin, berberine and other nutraceuticals on aging, cancer development, cancer stem cells and microRNAs. / 12.06.2017 / PubMed / Full text
Ursolic Acid Mediates Hepatic Protection through Enhancing of anti-aging Biomarkers. / 2018 / PubMed / Full text
The NAD /PARP1/SIRT1 Axis in Aging. / 06.2017 / PubMed / Full text
Intestinal Epithelial Sirtuin 1 Regulates Intestinal Inflammation During Aging in Mice by Altering the Intestinal Microbiota. / 09.2017 / PubMed / Full text
Kallistatin reduces vascular senescence and aging by regulating microRNA-34a-SIRT1 pathway. / 08.2017 / PubMed / Full text
Bushen-Yizhi formula ameliorates cognitive dysfunction through SIRT1/ER stress pathway in SAMP8 mice. / 25.07.2017 / PubMed / Full text
Caveolin-1 deficiency induces premature senescence with mitochondrial dysfunction. / 08.2017 / PubMed / Full text
Melatonin regulates the aging mouse hippocampal homeostasis via the sirtuin1-FOXO1 pathway. / 2017 / PubMed / Full text
Steroidogenesis decline accompanied with reduced antioxidation and endoplasmic reticulum stress in mice testes during ageing. / 02.2018 / PubMed / Full text
Exogenous nicotinamide supplementation and moderate physical exercise can attenuate the aging process in skeletal muscle of rats. / 08.2017 / PubMed / Full text
Caloric restriction delays early phases of carcinogenesis via effects on the tissue microenvironment. / 30.05.2017 / PubMed / Full text
During yeast chronological aging resveratrol supplementation results in a short-lived phenotype Sir2-dependent. / 08.2017 / PubMed / Full text
Sirtuin 7 is decreased in pulmonary fibrosis and regulates the fibrotic phenotype of lung fibroblasts. / 01.06.2017 / PubMed / Full text
Regulation of stem cell aging by SIRT1 - Linking metabolic signaling to epigenetic modifications. / 05.11.2017 / PubMed / Full text
Ampelopsin attenuates the atrophy of skeletal muscle from d-gal-induced aging rats through activating AMPK/SIRT1/PGC-1α signaling cascade. / 06.2017 / PubMed / Full text
SIRT1 Polymorphisms and Serum-Induced SIRT1 Protein Expression in Aging and Frailty: The CHAMP Study. / 01.07.2017 / PubMed / Full text
Melatonin reverses H O -induced senescence in SH-SY5Y cells by enhancing autophagy via sirtuin 1 deacetylation of the RelA/p65 subunit of NF-κB. / 08.2017 / PubMed / Full text
Alkylresorcinols activate SIRT1 and delay ageing in Drosophila melanogaster. / 02.03.2017 / PubMed / Full text
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