Aging genes 100: различия между версиями

Версия от 14:41, 31 марта 2021

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Naringenin alleviates nonalcoholic steatohepatitis in middle-aged Apoe mice: role of SIRT1. / 18.11.2020 / PubMed / Full text
Protective role of microglial HO-1 blockade in aging: Implication of iron metabolism. / 06.11.2020 / PubMed / Full text
Anti-aging effect of DL-β-hydroxybutyrate against hepatic cellular senescence induced by D-galactose or γ-irradiation via autophagic flux stimulation in male rats. / 01-02.2021 / PubMed / Full text
Exploring the extensive crosstalk between the antagonistic cytokines- TGF-β and TNF-α in regulating cancer pathogenesis. / 03.11.2020 / PubMed / Full text
Long non-coding RNA SNHG29 regulates cell senescence via p53/p21 signaling in spontaneous preterm birth. / 15.10.2020 / PubMed / Full text
Cognition Is Associated With Peripheral Immune Molecules in Healthy Older Adults: A Cross-Sectional Study. / 2020 / PubMed / Full text
Anti-aging effects of [i]Ribes meyeri[/i] anthocyanins on neural stem cells and aging mice. / 12.09.2020 / PubMed / Full text
Effects of a four week detraining period on physical, metabolic, and inflammatory profiles of elderly women who regularly participate in a program of strength training. / 2020 / PubMed / Full text
Contribution of Porphyromonas gingivalis lipopolysaccharide to experimental periodontitis in relation to aging. / 26.08.2020 / PubMed / Full text
New MoDC-Targeting TNF Fusion Proteins Enhance Cyclic Di-GMP Vaccine Adjuvanticity in Middle-Aged and Aged Mice. / 2020 / PubMed / Full text
Cognitive impairment in elderly patients with rheumatic disease and the effect of disease-modifying anti-rheumatic drugs. / 30.08.2020 / PubMed / Full text
Cotinine ameliorates memory and learning impairment in senescent mice. / 11.2020 / PubMed / Full text
Kynurenines link chronic inflammation to functional decline and physical frailty. / 20.08.2020 / PubMed / Full text
Voluntary exercise training attenuated the middle-aged maturity-induced cardiac apoptosis. / 15.10.2020 / PubMed / Full text
Preclinical Evaluation of a Food-Derived Functional Ingredient to Address Skeletal Muscle Atrophy. / 29.07.2020 / PubMed / Full text
Childhood survivors of high-risk neuroblastoma show signs of immune recovery and not immunosenescence. / 12.2020 / PubMed / Full text
FK506 induces lung lymphatic endothelial cell senescence and downregulates LYVE-1 expression, with associated decreased hyaluronan uptake. / 31.07.2020 / PubMed / Full text
Late-onset hypogonadism: Reductio ad absurdum of the cardiovascular risk-benefit of testosterone replacement therapy. / 11.2020 / PubMed / Full text
Doxorubicin generates senescent microglia that exhibit altered proteomes, higher levels of cytokine secretion, and a decreased ability to internalize amyloid β. / 15.10.2020 / PubMed / Full text
Time restricted feeding provides a viable alternative to alternate day fasting when evaluated in terms of redox homeostasis in rats. / 16.07.2020 / PubMed / Full text
Associations Between Plasma Immunomodulatory and Inflammatory Mediators With VACS Index Scores Among Older HIV-Infected Adults on Antiretroviral Therapy. / 2020 / PubMed / Full text
Chrysin Impact on Oxidative and Inflammation Damages in the Liver of Aged Male Rats. / 17.07.2020 / PubMed / Full text
Correction of immunosuppression in aged septic rats by human ghrelin and growth hormone through the vagus nerve-dependent inhibition of TGF-β production. / 16.07.2020 / PubMed / Full text
Epigenetics of neuroinflammation: Immune response, inflammatory response and cholinergic synaptic involvement evidenced by genome-wide DNA methylation analysis of delirious inpatients. / 10.2020 / PubMed / Full text
[i]Andrographis paniculata[/i] and Its Bioactive Diterpenoids Against Inflammation and Oxidative Stress in Keratinocytes. / 17.06.2020 / PubMed / Full text
Etanercept improves aging-induced cognitive deficits by reducing inflammation and vascular dysfunction in rats. / 01.10.2020 / PubMed / Full text
Bacterial antigen translocation and age as BMI-independent contributing factors on systemic inflammation in NAFLD patients. / 09.2020 / PubMed / Full text
Bone marrow mesenchymal stem cells improve thymus and spleen function of aging rats through affecting P21/PCNA and suppressing oxidative stress. / 19.06.2020 / PubMed / Full text
Glycolic acid adjusted to pH 4 stimulates collagen production and epidermal renewal without affecting levels of proinflammatory TNF-alpha in human skin explants. / 24.06.2020 / PubMed / Full text
A20 of nucleus pulposus cells plays a self-protection role via the nuclear factor-kappa B pathway in the inflammatory microenvironment. / 05.2020 / PubMed / Full text
Age-associated decline in neural, endocrine, and immune responses in men and women: Involvement of intracellular signaling pathways. / 15.08.2020 / PubMed / Full text
Classical and lectin complement pathways and markers of inflammation for investigation of susceptibility to infections among healthy older adults. / 2020 / PubMed / Full text
Activation of FoxO1/SIRT1/RANKL/OPG pathway may underlie the therapeutic effects of resveratrol on aging-dependent male osteoporosis. / 12.06.2020 / PubMed / Full text
The senescence-associated secretome as an indicator of age and medical risk. / 18.06.2020 / PubMed / Full text
Exercise Partially Rejuvenates Muscle Stem Cells. / 06.2020 / PubMed / Full text
Brazilian berry extract (Myrciaria jaboticaba): A promising therapy to minimize prostatic inflammation and oxidative stress. / 08.2020 / PubMed / Full text
Potential therapeutic effects of endothelial cells trans-differentiated from Wharton's Jelly-derived mesenchymal stem cells on altered vascular functions in aged diabetic rat model. / 2020 / PubMed / Full text
[Effect of fragmented sleep on postoperative cognitive function and central neuroinflammation]. / 05.05.2020 / PubMed / Full text
Can blocking inflammation enhance immunity during aging? / 05.2020 / PubMed / Full text
[FAS- and TNF-dependent ways participation in apoptosis mechanisms in hypotalumus in physiological and pathological aging.] / 2020 / PubMed
Ultrasound-guided continuous thoracic paravertebral block alleviates postoperative delirium in elderly patients undergoing esophagectomy: A randomized controlled trial. / 04.2020 / PubMed / Full text
17β-Estradiol improves insulin signalling and insulin resistance in the aged female hearts: Role of inflammatory and anti-inflammatory cytokines. / 15.07.2020 / PubMed / Full text
Synergistic Antitumor Efficacy of Magnetohyperthermia and Poly(lactic-co-glycolic acid)-Encapsulated Selol in Ehrlich Breast Adenocarcinoma Treatment in Elderly Swiss Mice. / 01.02.2020 / PubMed / Full text
Pinitol suppresses TNF-α-induced chondrocyte senescence. / 19.03.2020 / PubMed / Full text
[Aging of skin fibroblasts: genetic and epigenetic factors.] / 2019 / PubMed
Functional and traditional training improve muscle power and reduce proinflammatory cytokines in older women: A randomized controlled trial. / 01.07.2020 / PubMed / Full text
Associations of TNF-α -308 G>A and TNF-β 252 A>G with Physical Function and BNP-Rugao Longevity and Ageing Study. / 2020 / PubMed / Full text
3D TECA hydrogel reduces cellular senescence and enhances fibroblasts migration in wound healing. / 07.2018 / PubMed / Full text
Regulatory Effect of Anwulignan on the Immune Function Through Its Antioxidation and Anti-Apoptosis in D-Galactose-Induced Aging Mice. / 2020 / PubMed / Full text
Pretreatment Frailty Is Independently Associated With Increased Risk of Infections After Immunosuppression in Patients With Inflammatory Bowel Diseases. / 06.2020 / PubMed / Full text
The Citrus Flavonoid Naringenin Protects the Myocardium from Ageing-Dependent Dysfunction: Potential Role of SIRT1. / 2020 / PubMed / Full text
In the Absence of a TCR Signal IL-2/IL-12/18-Stimulated γδ T Cells Demonstrate Potent Anti-Tumoral Function Through Direct Killing and Senescence Induction in Cancer Cells. / 04.01.2020 / PubMed / Full text
Aging is associated with loss of beneficial effects of estrogen on leptin responsiveness in mice fed high fat diet: Role of estrogen receptor α and cytokines. / 03.2020 / PubMed / Full text
Mitochondrial Dysfunction and Alpha-Lipoic Acid: Beneficial or Harmful in Alzheimer's Disease? / 2019 / PubMed / Full text
Design, synthesis and evaluation of diosgenin carbamate derivatives as multitarget anti-Alzheimer's disease agents. / 01.02.2020 / PubMed / Full text
Oral Administration of Okara Soybean By-Product Attenuates Cognitive Impairment in a Mouse Model of Accelerated Aging. / 03.12.2019 / PubMed / Full text
Electric vagal nerve stimulation inhibits inflammation and improves early postoperation cognitive dysfunction in aged rats. / 23.11.2019 / PubMed / Full text
Metformin decreases LPS-induced inflammatory response in rabbit annulus fibrosus stem/progenitor cells by blocking HMGB1 release. / 26.11.2019 / PubMed / Full text
The effects of blueberry and strawberry serum metabolites on age-related oxidative and inflammatory signaling in vitro. / 11.12.2019 / PubMed / Full text
Arsenic induces human chondrocyte senescence and accelerates rat articular cartilage aging. / 01.2020 / PubMed / Full text
Bone Benefits of Fish Oil Supplementation Depend on its EPA and DHA Content. / 08.11.2019 / PubMed / Full text
Inflammaging phenotype in rhesus macaques is associated with a decline in epithelial barrier-protective functions and increased pro-inflammatory function in CD161-expressing cells. / 12.2019 / PubMed / Full text
Single-cell transcriptomics reveals expansion of cytotoxic CD4 T cells in supercentenarians. / 26.11.2019 / PubMed / Full text
Gut microbiota combined with metabolomics reveals the metabolic profile of the normal aging process and the anti-aging effect of FuFang Zhenshu TiaoZhi(FTZ) in mice. / 01.2020 / PubMed / Full text
Intervertebral disc ageing and degeneration: The antiapoptotic effect of oestrogen. / 01.2020 / PubMed / Full text
MicroRNA 16-5p is upregulated in calorie-restricted mice and modulates inflammatory cytokines of macrophages. / 30.01.2020 / PubMed / Full text
Aerobic exercise modulates cytokine profile and sleep quality in elderly. / 06.2019 / PubMed / Full text
Trehalose targets Nrf2 signal to alleviate d-galactose induced aging and improve behavioral ability. / 01.01.2020 / PubMed / Full text
Anti-Inflammatory and Anti-Aging Evaluation of Pigment-Protein Complex Extracted from [i]Chlorella Pyrenoidosa[/i]. / 16.10.2019 / PubMed / Full text
Inflammatory mediators and the risk of falls among older women with acute low back pain: data from Back Complaints in the Elders (BACE)-Brazil. / 03.2020 / PubMed / Full text
Acetylcholinesterase inhibitors targeting the cholinergic anti-inflammatory pathway: a new therapeutic perspective in aging-related disorders. / 03.10.2019 / PubMed / Full text
Study on Metabolic Trajectory of Liver Aging and the Effect of Fufang Zhenzhu Tiaozhi on Aging Mice. / 2019 / PubMed / Full text
Systemic Tumor Necrosis Factor-Alpha Trajectories Relate to Brain Health in Typically Aging Older Adults. / 13.07.2020 / PubMed / Full text
Targeting senescence improves angiogenic potential of adipose-derived mesenchymal stem cells in patients with preeclampsia. / 14.09.2019 / PubMed / Full text
Suppression of gut dysbiosis by Bifidobacterium longum alleviates cognitive decline in 5XFAD transgenic and aged mice. / 14.08.2019 / PubMed / Full text
Moderate hyperoxia induces senescence in developing human lung fibroblasts. / 01.11.2019 / PubMed / Full text
Aging-related carcinoembryonic antigen-related cell adhesion molecule 1 signaling promotes vascular dysfunction. / 12.2019 / PubMed / Full text
Microglia Express Insulin-Like Growth Factor-1 in the Hippocampus of Aged APP /PS1 Transgenic Mice. / 2019 / PubMed / Full text
Age- and diet-specific effects of chronic exposure to chlorpyrifos on hormones, inflammation and gut microbiota in rats. / 09.2019 / PubMed / Full text
Knockout of longevity gene Sirt1 in zebrafish leads to oxidative injury, chronic inflammation, and reduced life span. / 2019 / PubMed / Full text
Glycation of macrophages induces expression of pro-inflammatory cytokines and reduces phagocytic efficiency. / 29.07.2019 / PubMed / Full text
Tamoxifen-induced, intestinal-specific deletion of [i]Slc5a6[/i] in adult mice leads to spontaneous inflammation: involvement of NF-κB, NLRP3, and gut microbiota. / 01.10.2019 / PubMed / Full text
Systems biology and network pharmacology of frailty reveal novel epigenetic targets and mechanisms. / 22.07.2019 / PubMed / Full text
Inflammatory markers and bone health in postmenopausal women: a cross-sectional overview. / 2019 / PubMed / Full text
TNF-α-driven inflammation and mitochondrial dysfunction define the platelet hyperreactivity of aging. / 29.08.2019 / PubMed / Full text
Plasma Cells Are Obligate Effectors of Enhanced Myelopoiesis in Aging Bone Marrow. / 20.08.2019 / PubMed / Full text
Aging-induced elevation in circulating complement C1q level is associated with arterial stiffness. / 09.2019 / PubMed / Full text
Immune Mechanisms Underlying Susceptibility to Endotoxin Shock in Aged Hosts: Implication in Age-Augmented Generalized Shwartzman Reaction. / 02.07.2019 / PubMed / Full text
Inflammation-related genes are associated with epigenetic aging in HIV. / 12.2019 / PubMed / Full text
Function, Oxidative, and Inflammatory Stress Parameters in Immune Cells as Predictive Markers of Lifespan throughout Aging. / 2019 / PubMed / Full text
The Impact of Prophylactic Lacosamide on LPS-Induced Neuroinflammation in Aged Rats. / 10.2019 / PubMed / Full text
Impaired sleep quality is associated with concurrent elevations in inflammatory markers: are post-menopausal women at greater risk? / 08.07.2019 / PubMed / Full text
Potential effects of rapeseed peptide Maillard reaction products on aging-related disorder attenuation and gut microbiota modulation in d-galactose induced aging mice. / 17.07.2019 / PubMed / Full text
Ellagic acid dose and time-dependently abrogates d-galactose-induced animal model of aging: Investigating the role of PPAR-γ. / 01.09.2019 / PubMed / Full text
Lactobacillus sp. improved microbiota and metabolite profiles of aging rats. / 08.2019 / PubMed / Full text
Local and systemic effects of aging on acute pancreatitis. / 07.2019 / PubMed / Full text
Salicin prevents TNF-α-induced cellular senescence in human umbilical vein endothelial cells (HUVECs). / 12.2019 / PubMed / Full text
Age-related dynamics of pro-inflammatory cytokines in equine bronchoalveolar lavage (BAL) fluid and peripheral blood from horses managed on pasture. / 09.2019 / PubMed / Full text
The beneficial effects of 15 units of high-intensity circuit training in women is modified by age, baseline insulin resistance and physical capacity. / 06.2019 / PubMed / Full text
The effects of vitamin-rich carbohydrate pretreatment on the surgical stress response and S-100β after splenectomy in elderly rats. / 15.05.2019 / PubMed / Full text
Stem Cell-Derived Exosomes Prevent Aging-Induced Cardiac Dysfunction through a Novel Exosome/lncRNA MALAT1/NF-[i]κ[/i]B/TNF-[i]α[/i] Signaling Pathway. / 2019 / PubMed / Full text
Endothelial PPARγ Is Crucial for Averting Age-Related Vascular Dysfunction by Stalling Oxidative Stress and ROCK. / 10.2019 / PubMed / Full text
Melatonin alleviates cognition impairment by antagonizing brain insulin resistance in aged rats fed a high-fat diet. / 09.2019 / PubMed / Full text
Age-related cytokine effects on cancer-related fatigue and quality of life in acute myeloid leukemia. / 04.2020 / PubMed / Full text
Protective effect of vildagliptin on TNF-α-induced chondrocyte senescence. / 07.2019 / PubMed / Full text
Platelet-Rich Plasma (PRP) From Older Males With Knee Osteoarthritis Depresses Chondrocyte Metabolism and Upregulates Inflammation. / 08.2019 / PubMed / Full text
Effects of sulforaphane on D-galactose-induced liver aging in rats: Role of keap-1/nrf-2 pathway. / 15.07.2019 / PubMed / Full text
Protective effects of pyrroloquinoline quinine against oxidative stress-induced cellular senescence and inflammation in human renal tubular epithelial cells via Keap1/Nrf2 signaling pathway. / 07.2019 / PubMed / Full text
Long-term every-other-day administration of DMAMCL has little effect on aging and age-associated physiological decline in mice. / 02.05.2019 / PubMed / Full text
Novel insights of elevated systemic levels of bisphenol-A (BPA) linked to poor glycemic control, accelerated cellular senescence and insulin resistance in patients with type 2 diabetes. / 08.2019 / PubMed / Full text
Resveratrol attenuates inflammation environment-induced nucleus pulposus cell senescence [i]in vitro[/i]. / 31.05.2019 / PubMed / Full text
Photobiomodulation and Coenzyme Q Treatments Attenuate Cognitive Impairment Associated With Model of Transient Global Brain Ischemia in Artificially Aged Mice. / 2019 / PubMed / Full text
Circulating factors associated with sarcopenia during ageing and after intensive lifestyle intervention. / 06.2019 / PubMed / Full text
2, 3, 4', 5-tetrahydroxystilbene-2-0-β-d Glycoside Attenuates Age- and Diet-Associated Non-Alcoholic Steatohepatitis and Atherosclerosis in LDL Receptor Knockout Mice and Its Possible Mechanisms. / 01.04.2019 / PubMed / Full text
N-acetylcysteine and alpha-lipoic acid improve antioxidant defenses and decrease oxidative stress, inflammation and serum lipid levels in ovariectomized rats via estrogen-independent mechanisms. / 05.2019 / PubMed / Full text
Neuroprotective Effect of Dioscin on the Aging Brain. / 30.03.2019 / PubMed / Full text
CSF Cytokines in Aging, Multiple Sclerosis, and Dementia. / 2019 / PubMed / Full text
Neuroprotective effects of targeting BET proteins for degradation with dBET1 in aged mice subjected to ischemic stroke. / 07.2019 / PubMed / Full text
A double-blind, randomized trial on the effect of a broad-spectrum dietary supplement on key biomarkers of cellular aging including inflammation, oxidative stress, and DNA damage in healthy adults. / 04.01.2017 / PubMed / Full text
A New Understanding of the Role of IL-1 in Age-Related Intervertebral Disc Degeneration in a Murine Model. / 08.2019 / PubMed / Full text
Methane ameliorates post-operative cognitive dysfunction by inhibiting microglia NF-κB/MAPKs pathway and promoting IL-10 expression in aged mice. / 06.2019 / PubMed / Full text
Age-dependent hepatic alterations induced by a high-fat high-fructose diet. / 05.2019 / PubMed / Full text
The senescent status of endothelial cells affects proliferation, inflammatory profile and SOX2 expression in bone marrow-derived mesenchymal stem cells. / 06.2019 / PubMed / Full text
Reduced CXCL1/GRO chemokine plasma levels are a possible biomarker of elderly depression. / 15.04.2019 / PubMed / Full text
Nontuberculous mycobacterium M. avium infection predisposes aged mice to cardiac abnormalities and inflammation. / 06.2019 / PubMed / Full text
Epigenetic Age Acceleration in Adolescence Associates With BMI, Inflammation, and Risk Score for Middle Age Cardiovascular Disease. / 01.07.2019 / PubMed / Full text
Converging Paths of Pulmonary Arterial Hypertension and Cellular Senescence. / 07.2019 / PubMed / Full text
Gender-specific association of body composition with inflammatory and adipose-related markers in healthy elderly Europeans from the NU-AGE study. / 09.2019 / PubMed / Full text
Lifelong aerobic exercise protects against inflammaging and cancer. / 2019 / PubMed / Full text
Individual and combined effects of salinity and lipopolysaccharides on the immune response of juvenile Takifugu fasciatus. / 06.2019 / PubMed / Full text
The Role of Genetic Profile in Functional Performance Adaptations to Exercise Training or Physical Activity: A Systematic Review of the Literature. / 01.08.2019 / PubMed / Full text
Impact of simulated biological aging on physicochemical and biocompatibility properties of cyclic olefin copolymers. / 04.2019 / PubMed / Full text
Protective Role of Endogenous Kallistatin in Vascular Injury and Senescence by Inhibiting Oxidative Stress and Inflammation. / 2018 / PubMed / Full text
Lifelong exercise practice and immunosenescence: Master athletes cytokine response to acute exercise. / 03.2019 / PubMed / Full text
Human T2R38 Bitter Taste Receptor Expression in Resting and Activated Lymphocytes. / 2018 / PubMed / Full text
Ameliorative effect of supercritical fluid extract of Chrysanthemum indicum Linnén against D-galactose induced brain and liver injury in senescent mice via suppression of oxidative stress, inflammation and apoptosis. / 24.04.2019 / PubMed / Full text
[Effect of saponins extracted from Panax japonicas on inhibiting myocardial fibrosis by TGF-β1/Smad3 signaling pathway in aging rats]. / 11.2018 / PubMed / Full text
Aging and Hyperglycemia Intensify Dyslipidemia-Induced Oxidative Stress and Inflammation in Rats: Assessment of Restorative Potentials of ALA and EPA + DHA. / 06.2019 / PubMed / Full text
CD56bright cells respond to stimulation until very advanced age revealing increased expression of cellular protective proteins SIRT1, HSP70 and SOD2. / 2018 / PubMed / Full text
Role of Exercise in Vascular Function and Inflammatory Profile in Age-Related Obesity. / 2018 / PubMed / Full text
Establishment of a lethal aged mouse model of human respiratory syncytial virus infection. / 01.2019 / PubMed / Full text
Elevated truncated oxidized phospholipids as a factor exacerbating ALI in the aging lungs. / 03.2019 / PubMed / Full text
Effect of Myricetin on Primary Open-angle Glaucoma. / 2018 / PubMed / Full text
Chronic rhinosinusitis in elderly patients is associated with an exaggerated neutrophilic proinflammatory response to pathogenic bacteria. / 03.2019 / PubMed / Full text
Nuclear Translocation of Argonaute 2 in Cytokine-Induced Senescence. / 2018 / PubMed / Full text
Dual functions for OVAAL in initiation of RAF/MEK/ERK prosurvival signals and evasion of p27-mediated cellular senescence. / 11.12.2018 / PubMed / Full text
Association of pro-inflammatory cytokines and monocyte subtypes in older and younger patients on clinical outcomes after mechanical circulatory support device implantation. / 02.2019 / PubMed / Full text
Adipose TSHB in Humans and Serum TSH in Hypothyroid Rats Inform About Cellular Senescence. / 2018 / PubMed / Full text
Involvement of ERK1/2 activation in the gene expression of senescence-associated secretory factors in human hepatic stellate cells. / 05.2019 / PubMed / Full text
Higher levels of tumor necrosis factor β are associated with frailty in socially vulnerable community-dwelling older adults. / 06.11.2018 / PubMed / Full text
Epigenetics of Delirium and Aging: Potential Role of DNA Methylation Change on Cytokine Genes in Glia and Blood Along With Aging. / 2018 / PubMed / Full text
Polydatin suppresses nucleus pulposus cell senescence, promotes matrix homeostasis and attenuates intervertebral disc degeneration in rats. / 11.2018 / PubMed / Full text
Ellagic acid reveals promising anti-aging effects against d-galactose-induced aging on human neuroblastoma cell line, SH-SY5Y: A mechanistic study. / 12.2018 / PubMed / Full text
The Neuro-Immuno-Senescence Integrative Model (NISIM) on the Negative Association Between Parasympathetic Activity and Cellular Senescence. / 2018 / PubMed / Full text
Human umbilical cord blood plasma alleviates age-related olfactory dysfunction by attenuating peripheral TNF-α expression. / 04.2019 / PubMed / Full text
Manipulating fenestrations in young and old liver sinusoidal endothelial cells. / 01.01.2019 / PubMed / Full text
The Synergy of Aging and LPS Exposure in a Mouse Model of Parkinson's Disease. / 10.2018 / PubMed / Full text
Myeloid cell-derived tumor necrosis factor-alpha promotes sarcopenia and regulates muscle cell fusion with aging muscle fibers. / 12.2018 / PubMed / Full text
mRNA expressions of peroxisome proliferator-activated receptor gamma coactivator 1α, tumor necrosis factor-α, and interleukin-6 in paraspinal muscles of patients with lumbar kyphosis: a preliminary study. / 2018 / PubMed / Full text
Leptin stimulates the release of pro-inflammatory cytokines in hypothalamic astrocyte cultures from adult and aged rats. / 12.2018 / PubMed / Full text
Effects of 8-week kettlebell training on body composition, muscle strength, pulmonary function, and chronic low-grade inflammation in elderly women with sarcopenia. / 02.10.2018 / PubMed / Full text
Research advances in the regulation of the putative ovarian germline stem cell niche on female germline stem cells. / 04.2019 / PubMed / Full text
Efficacy and safety of biological agents in the older rheumatoid arthritis patients compared to Young: A systematic review and meta-analysis. / 04.2019 / PubMed / Full text
Leptin, hsCRP, TNF-α and IL-6 levels from normal aging to dementia: Relationship with cognitive and functional status. / 10.2018 / PubMed / Full text
Systemic Inflammation Mediates Age-Related Cognitive Deficits. / 2018 / PubMed / Full text
Featured Article: Deterioration of visual function mediated by senescence-associated endoplasmic reticulum stress in inflammatory tie2-TNF mice. / 08.2018 / PubMed / Full text
Quercetin Enhances Ligand-induced Apoptosis in Senescent Idiopathic Pulmonary Fibrosis Fibroblasts and Reduces Lung Fibrosis In Vivo. / 01.2019 / PubMed / Full text
Bioactive Peptide Improves Diet-Induced Hepatic Fat Deposition and Hepatocyte Proinflammatory Response in SAMP8 Ageing Mice. / 2018 / PubMed / Full text
Senescence and odontoblastic differentiation of dental pulp cells. / 01.2018 / PubMed / Full text
Effect of resistance training on inflammatory markers of older adults: A meta-analysis. / 01.10.2018 / PubMed / Full text
Heat-induced extracellular HSP72 release is blunted in elderly diabetic people compared with healthy middle-aged and older adults, but it is partially restored by resistance training. / 01.10.2018 / PubMed / Full text
Repeated abortion in adulthood induces cognition impairment in aged mice. / 30.07.2018 / PubMed / Full text
Cumulus cell-released tumor necrosis factor (TNF)-α promotes post-ovulatory aging of mouse oocytes. / 26.07.2018 / PubMed / Full text
Comparison of neurotoxicity of dexmedetomidine as an adjuvant in brachial plexus block in rats of different age. / 09-10.2018 / PubMed / Full text
Inflammatory cytokines and immune system modulation by aerobic versus resisted exercise training for elderly. / 03.2018 / PubMed / Full text
Age-Related Adverse Inflammatory and Metabolic Changes Begin Early in Adulthood. / 15.02.2019 / PubMed / Full text
Inhibition of programmed necrosis limits infarct size through altered mitochondrial and immune responses in the aged female rat heart. / 01.11.2018 / PubMed / Full text
Accumulation of T-helper 22 cells, interleukin-22 and myeloid-derived suppressor cells promotes gastric cancer progression in elderly patients. / 07.2018 / PubMed / Full text
Co-culturing nucleus pulposus mesenchymal stem cells with notochordal cell-rich nucleus pulposus explants attenuates tumor necrosis factor-α-induced senescence. / 26.06.2018 / PubMed / Full text
The expression of C1 inhibitor (C1INH) in macrophages is upregulated by retinal pigment epithelial cells - implication in subretinal immune privilege in the aging eye. / 13.06.2018 / PubMed / Full text
Regulation of p38 mitogen-activated kinase-mediated fetal membrane senescence by statins. / 10.2018 / PubMed / Full text
Identification of proteins potentially associated with renal aging in rats. / 14.06.2018 / PubMed / Full text
Aerobic Exercise Protects from Pseudomonas aeruginosa-Induced Pneumonia in Elderly Mice. / 2018 / PubMed / Full text
Serum Tumor Necrosis Factor-alpha associates with Myocardial Oxygen Demand and Exercise Tolerance in Postmenopausal Women. / 2018 / PubMed / Full text
Exercise related anxiety-like behaviours are mediated by TNF receptor signaling, but not depression-like behaviours. / 15.09.2018 / PubMed / Full text
Accelerated vascular aging and persistent cognitive impairment in older female breast cancer survivors. / 06.2018 / PubMed / Full text
Features of Cytokine Profile in Different Age Groups. / 2014 / PubMed / Full text
Anthocyanins Improve Hippocampus-Dependent Memory Function and Prevent Neurodegeneration via JNK/Akt/GSK3β Signaling in LPS-Treated Adult Mice. / 01.2019 / PubMed / Full text
Supplementation with eicosapentaenoic acid and docosahexaenoic acid reduces high levels of circulating proinflammatory cytokines in aging adults: A randomized, controlled study. / 05.2018 / PubMed / Full text
Effects of nutritional state, aging and high chronic intake of sucrose on brain protein synthesis in rats: modulation of it by rutin and other micronutrients. / 23.05.2018 / PubMed / Full text
Plasma zinc in institutionalized elderly individuals: Relation with immune and cardiometabolic biomarkers. / 12.2018 / PubMed / Full text
Pentoxifylline, dexamethasone and azithromycin demonstrate distinct age-dependent and synergistic inhibition of TLR- and inflammasome-mediated cytokine production in human newborn and adult blood in vitro. / 2018 / PubMed / Full text
Necroptosis increases with age and is reduced by dietary restriction. / 08.2018 / PubMed / Full text
Age-Related Changes to Human Tear Composition. / 01.04.2018 / PubMed / Full text
Inhibition of UVB-induced pro-inflammatory cytokines and MMP expression by Zanthoxylum rhetsa bark extract and its active constituent hesperidin. / 08.2018 / PubMed / Full text
Effects of Baicalein on Cortical Proinflammatory Cytokines and the Intestinal Microbiome in Senescence Accelerated Mouse Prone 8. / 18.07.2018 / PubMed / Full text
Probiotic Potential of [i]Enterococcus faecium[/i] Isolated from Chicken Cecum with Immunomodulating Activity and Promoting Longevity in [i]Caenorhabditis elegans[/i]. / 28.06.2018 / PubMed / Full text
Sex Differences in Adipose Tissue CD8 T Cells and Regulatory T Cells in Middle-Aged Mice. / 2018 / PubMed / Full text
Elderly dendritic cells respond to LPS/IFN-γ and CD40L stimulation despite incomplete maturation. / 2018 / PubMed / Full text
Inosine improves cognitive function and decreases aging-induced oxidative stress and neuroinflammation in aged female rats. / 10.2018 / PubMed / Full text
Cytokine Responses to Acute Exercise in Healthy Older Adults: The Effect of Cardiorespiratory Fitness. / 2018 / PubMed / Full text
No requirement of interlukine-1 for long-term potentiation in the anterior cingulate cortex of adult mice. / 01-12.2018 / PubMed / Full text
[Electroacupuncture Intervention Improves Physical Power of Aged Rats with Low Testosterone by Reducing Chronic Inflammatory Response of Leydig Cells]. / 25.03.2018 / PubMed / Full text
Predominant gut Lactobacillus murinus strain mediates anti-inflammaging effects in calorie-restricted mice. / 21.03.2018 / PubMed / Full text
Proximity of Cytomegalovirus-Specific CD8 T Cells to Replicative Senescence in Human Immunodeficiency Virus-Infected Individuals. / 2018 / PubMed / Full text
Xanthohumol exerts protective effects in liver alterations associated with aging. / 03.2019 / PubMed / Full text
Age-related pro-inflammatory and pro-angiogenic changes in human aqueous humor. / 2018 / PubMed / Full text
Exercise and taurine in inflammation, cognition, and peripheral markers of blood-brain barrier integrity in older women. / 07.2018 / PubMed / Full text
Normal aging induces A1-like astrocyte reactivity. / 20.02.2018 / PubMed / Full text
Human blood MAIT cell subsets defined using MR1 tetramers. / 05.2018 / PubMed / Full text
The pro-inflammatory phenotype of the human non-classical monocyte subset is attributed to senescence. / 15.02.2018 / PubMed / Full text
Nucleoside Reverse Transcriptase Inhibitors (NRTIs) Induce Pathological Pain through Wnt5a-Mediated Neuroinflammation in Aging Mice. / 06.2018 / PubMed / Full text
Aged Chinese-origin rhesus macaques infected with SIV develop marked viremia in absence of clinical disease, inflammation or cognitive impairment. / 01.02.2018 / PubMed / Full text
Protective effect of crocin against d-galactose-induced aging in mice. / 01-02.2018 / PubMed / Full text
Osteogenic protein-1 attenuates the inflammatory cytokine-induced NP cell senescence through regulating the ROS/NF-κB pathway. / 03.2018 / PubMed / Full text
Metformin regulates metabolic and nonmetabolic pathways in skeletal muscle and subcutaneous adipose tissues of older adults. / 04.2018 / PubMed / Full text
Impairment of Several Immune Functions and Redox State in Blood Cells of Alzheimer's Disease Patients. Relevant Role of Neutrophils in Oxidative Stress. / 2017 / PubMed / Full text
[Effect of saponins extracted from Panax japonicus on inhibiting cardiomyocyte apoptosis by AMPK/Sirt1/NF-κB signaling pathway in aging rats]. / 12.2017 / PubMed / Full text
Premature aging in behavior and immune functions in tyrosine hydroxylase haploinsufficient female mice. A longitudinal study. / 03.2018 / PubMed / Full text
Differential microRNA expression profiles and bioinformatics analysis between young and aging spontaneously hypertensive rats. / 03.2018 / PubMed / Full text
Antagonism of cysteinyl leukotriene receptor 1 (cysLTR1) by montelukast suppresses cell senescence of chondrocytes. / 03.2018 / PubMed / Full text
Rapamycin prevents the intervertebral disc degeneration via inhibiting differentiation and senescence of annulus fibrosus cells. / 18.01.2018 / PubMed / Full text
Memory enhancement and protective effects of crocin against D-galactose aging model in the hippocampus of Wistar rats. / 11.2017 / PubMed / Full text
The additive effect of aging on sepsis-induced cognitive impairment and neuroinflammation. / 15.01.2018 / PubMed / Full text
Cytomegalovirus-Specific T Cells Restricted by HLA-Cw*0702 Increase Markedly with Age and Dominate the CD8 T-Cell Repertoire in Older People. / 2017 / PubMed / Full text
Polar extract of Curcuma longa protects cartilage homeostasis: possible mechanism of action. / 10.2018 / PubMed / Full text
Immunoglobulin therapy ameliorates the phenotype and increases lifespan in the severely affected dystrophin-utrophin double knockout mice. / 12.2017 / PubMed / Full text
The Association between Modulating Inflammatory Cytokines and Constipation of Geriatrics in Iran. / 10.2017 / PubMed / Full text
Immune senescence and biomarkers profile of Bambuí aged population-based cohort. / 03.2018 / PubMed / Full text
SIRT6 histone deacetylase functions as a potential oncogene in human melanoma. / 09.2017 / PubMed / Full text
TNF-α antagonism with etanercept enhances penile NOS expression, cavernosal reactivity, and testosterone levels in aged rats. / 02.2018 / PubMed / Full text
Dietary Animal Plasma Proteins Improve the Intestinal Immune Response in Senescent Mice. / 11.12.2017 / PubMed / Full text
Effects of the Consumption of Milk Biofortified with Selenium, Vitamin E, and Different Fatty Acid Profile on Immune Response in the Elderly. / 02.2018 / PubMed / Full text
Phase angle is related with inflammatory and oxidative stress biomarkers in older women. / 02.2018 / PubMed / Full text
Practice Patterns in Hepatitis B Virus Screening Before Cancer Chemotherapy in a Major US Hospital Network. / 01.2018 / PubMed / Full text
Insulin-Like Growth Factor-1 and Neuroinflammation. / 2017 / PubMed / Full text
Enhancement of cutaneous immunity during aging by blocking p38 mitogen-activated protein (MAP) kinase-induced inflammation. / 09.2018 / PubMed / Full text
Fisetin as a caloric restriction mimetic protects rat brain against aging induced oxidative stress, apoptosis and neurodegeneration. / 15.01.2018 / PubMed / Full text
Tucum-do-Cerrado (Bactris setosa Mart.) May Promote Anti-Aging Effect by Upregulating SIRT1-Nrf2 Pathway and Attenuating Oxidative Stress and Inflammation. / 14.11.2017 / PubMed / Full text
Time-response characteristic and potential biomarker identification of heavy metal induced toxicity in zebrafish. / 01.2018 / PubMed / Full text
Targeting of AUF1 to vascular endothelial cells as a novel anti-aging therapy. / 08.2017 / PubMed / Full text
Age-related decline of the acute local inflammation response: a mitigating role for the adenosine A receptor. / 18.10.2017 / PubMed / Full text
Anthocyanins Delay Ageing-Related Degenerative Changes in the Liver. / 12.2017 / PubMed / Full text
Nicotine-Induced Neuroprotection against Cognitive Dysfunction after Partial Hepatectomy Involves Activation of BDNF/TrkB Signaling Pathway and Inhibition of NF-κB Signaling Pathway in Aged Rats. / 06.03.2018 / PubMed / Full text
Study of insulin vascular sensitivity in aortic rings and endothelial cells from aged rats subjected to caloric restriction: Role of perivascular adipose tissue. / 08.2018 / PubMed / Full text
Tumor necrosis factor-alpha and soluble TNF-alpha receptor responses in young vs. middle-aged males following eccentric exercise. / 15.12.2017 / PubMed / Full text
Chronic inflammation - inflammaging - in the ageing cochlea: A novel target for future presbycusis therapy. / 11.2017 / PubMed / Full text
Allogeneic Mesenchymal Stem Cells Ameliorate Aging Frailty: A Phase II Randomized, Double-Blind, Placebo-Controlled Clinical Trial. / 12.10.2017 / PubMed / Full text
Protective effect of xanthohumol against age-related brain damage. / 11.2017 / PubMed / Full text
7,8-Dihydroxyflavone attenuates TNF-α-induced skin aging in Hs68 human dermal fibroblast cells via down-regulation of the MAPKs/Akt signaling pathways. / 11.2017 / PubMed / Full text
Influenza vaccine-mediated protection in older adults: Impact of influenza infection, cytomegalovirus serostatus and vaccine dosage. / 01.07.2018 / PubMed / Full text
Aged blood factors decrease cellular responses associated with delayed gingival wound repair. / 2017 / PubMed / Full text
Age-associated alterations in the levels of cytotoxic lipid molecular species and oxidative stress in the murine thymus are reduced by growth hormone treatment. / 10.2017 / PubMed / Full text
Force-time characteristics during sustained maximal handgrip effort according to age and clinical condition. / 11.2017 / PubMed / Full text
[Age-related aspects of the involvement of heat shock proteins in the pathogenesis of osteoarthritis]. / 2017 / PubMed
Electroacupuncture alleviates surgery-induced cognitive dysfunction by increasing α7-nAChR expression and inhibiting inflammatory pathway in aged rats. / 17.10.2017 / PubMed / Full text
Association between local inflammation and breast tissue age-related lobular involution among premenopausal and postmenopausal breast cancer patients. / 2017 / PubMed / Full text
Cytochrome P450-2E1 is involved in aging-related kidney damage in mice through increased nitroxidative stress. / 11.2017 / PubMed / Full text
Tumor necrosis factor alpha polymorphisms are associated with Parkinson's disease age at onset. / 29.09.2017 / PubMed / Full text
Involvement of insulin resistance in D-galactose-induced age-related dementia in rats: Protective role of metformin and saxagliptin. / 2017 / PubMed / Full text
Lower levels of interleukin-1β gene expression are associated with impaired Langerhans' cell migration in aged human skin. / 01.2018 / PubMed / Full text
Predictive value of multiple cytokines and chemokines for mortality in an admixed population: 15-year follow-up of the Bambui-Epigen (Brazil) cohort study of aging. / 11.2017 / PubMed / Full text

CD4

Identification of Key Genes and Potential New Biomarkers for Ovarian Aging: A Study Based on RNA-Sequencing Data. / 2020 / PubMed / Full text
Distinct Age-Related Epigenetic Signatures in CD4 and CD8 T Cells. / 2020 / PubMed / Full text
IL-1β-MyD88-mTOR Axis Promotes Immune-Protective IL-17A Foxp3 Cells During Mucosal Infection and Is Dysregulated With Aging. / 2020 / PubMed / Full text
Thymus involution sets the clock of declined immunity and repair with aging. / 25.11.2020 / PubMed / Full text
Food insecurity and T-cell dysregulation in women living with HIV on antiretroviral therapy. / 28.11.2020 / PubMed / Full text
Rapamycin Eyedrops Increased CD4 Foxp3 Cells and Prevented Goblet Cell Loss in the Aged Ocular Surface. / 24.11.2020 / PubMed / Full text
Antioxidants N-Acetylcysteine and Vitamin C Improve T Cell Commitment to Memory and Long-Term Maintenance of Immunological Memory in Old Mice. / 19.11.2020 / PubMed / Full text
Evolution of comorbidities in people living with HIV between 2004 and 2014: cross-sectional analyses from ANRS CO3 Aquitaine cohort. / 16.11.2020 / PubMed / Full text
Impact of age on CD4 recovery and viral suppression over time among adults living with HIV who initiated antiretroviral therapy in the African Cohort Study. / 12.11.2020 / PubMed / Full text
hPMSCs protects against D-galactose-induced oxidative damage of CD4 T cells through activating Akt-mediated Nrf2 antioxidant signaling. / 04.11.2020 / PubMed / Full text
Substantial gap in primary care: older adults with HIV presenting late to care. / 31.10.2020 / PubMed / Full text
Quantitative Digitography Measures Fine Motor Disturbances in Chronically Treated HIV Similar to Parkinson's Disease. / 2020 / PubMed / Full text
Monocyte and T Cell Immune Phenotypic Profiles Associated With Age Advancement Differ Between People With HIV, Lifestyle-Comparable Controls and Blood Donors. / 2020 / PubMed / Full text
HIV and three dimensions of Wisdom: Association with cognitive function and physical and mental well-being: For: Psychiatry Research. / 12.2020 / PubMed / Full text
CD8 T cells are present at low levels in the white matter with physiological and pathological aging. / 13.10.2020 / PubMed / Full text
Immunotherapy in older patients with cancer. / 26.07.2020 / PubMed / Full text
Multiple genetic programs contribute to CD4 T cell memory differentiation and longevity by maintaining T cell quiescence. / 11.2020 / PubMed / Full text
Conventional Treatment for Multiple Myeloma Drives Premature Aging Phenotypes and Metabolic Dysfunction in T Cells. / 2020 / PubMed / Full text
Immunosenescence: the role of age in multiple sclerosis. / 19.09.2020 / PubMed / Full text
Umbilical cord mesenchymal stem cells protect thymus structure and function in aged C57 mice by downregulating aging-related genes and upregulating autophagy- and anti-oxidative stress-related genes. / 14.09.2020 / PubMed / Full text
Impaired Cytotoxic CD8 T Cell Response in Elderly COVID-19 Patients. / 18.09.2020 / PubMed / Full text
What are the roles of antibodies versus a durable, high quality T-cell response in protective immunity against SARS-CoV-2? / 11.12.2020 / PubMed / Full text
Per2 Upregulation in Circulating Hematopoietic Progenitor Cells During Chronic HIV Infection. / 2020 / PubMed / Full text
COVID-19: age, Interleukin-6, C-reactive protein, and lymphocytes as key clues from a multicentre retrospective study. / 2020 / PubMed / Full text
Immunosenescence profiles are not associated with muscle strength, physical performance and sarcopenia risk in very old adults: The Newcastle 85+ Study. / 09.2020 / PubMed / Full text
Homeostasis and the functional roles of CD4 Treg cells in aging. / 10.2020 / PubMed / Full text
A Comprehensive Evaluation of the Impact of Bovine Milk Containing Different Beta-Casein Profiles on Gut Health of Ageing Mice. / 19.07.2020 / PubMed / Full text
Premature aging of circulating T cells predicts all-cause mortality in hemodialysis patients. / 13.07.2020 / PubMed / Full text
In-depth immune cellular profiling reveals sex-specific associations with frailty. / 2020 / PubMed / Full text
CD70 contributes to age-associated T cell defects and overwhelming inflammatory responses. / 19.06.2020 / PubMed / Full text
Comparison of Overall and Comorbidity-Free Life Expectancy Between Insured Adults With and Without HIV Infection, 2000-2016. / 01.06.2020 / PubMed / Full text
Comparative Analysis of Age-Related Changes in Lacrimal Glands and Meibomian Glands of a C57BL/6 Male Mouse Model. / 11.06.2020 / PubMed / Full text
Thymus aging in mice deficient in either EphB2 or EphB3, two master regulators of thymic epithelium development. / 10.2020 / PubMed / Full text
CD8 T-cell senescence and skewed lymphocyte subsets in young Dyskeratosis Congenita patients with PARN and DKC1 mutations. / 09.2020 / PubMed / Full text
Short-Term Environmental Enrichment is a Stronger Modulator of Brain Glial Cells and Cervical Lymph Node T Cell Subtypes than Exercise or Combined Exercise and Enrichment. / 25.05.2020 / PubMed / Full text
Viral and host factors related to the clinical outcome of COVID-19. / 07.2020 / PubMed / Full text
Use of comedications and potential drug-drug interactions in people living with HIV in China. / 07.2020 / PubMed / Full text
CD4 T helper 17 cell response of aged mice promotes prostate cancer cell migration and invasion. / 07.2020 / PubMed / Full text
The Rules of Human T Cell Fate [i]in vivo[/i]. / 2020 / PubMed / Full text
CD4/CD8 ratio, comorbidities, and aging in treated HIV infected individuals on viral suppression. / 21.04.2020 / PubMed / Full text
The effects of advanced maternal age on T-cell subsets at the maternal-fetal interface prior to term labor and in the offspring: a mouse study. / 07.2020 / PubMed / Full text
Structural and Functional Changes in the Mesenteric Lymph Nodes in Humans during Aging. / 03.2020 / PubMed / Full text
Neurocognitive Functioning is Associated with Self-Reported and Performance-Based Treatment Management Abilities in People Living with HIV with Low Health Literacy. / 24.07.2020 / PubMed / Full text
Blockade of Stat3 oncogene addiction induces cellular senescence and reveals a cell-nonautonomous activity suitable for cancer immunotherapy. / 2020 / PubMed / Full text
Age-related changes in T lymphocytes of patients with head and neck squamous cell carcinoma. / 2020 / PubMed / Full text
Immunological history governs human stem cell memory CD4 heterogeneity via the Wnt signaling pathway. / 10.02.2020 / PubMed / Full text
Estimating HIV Management and Comorbidity Costs Among Aging HIV Patients in the United States: A Systematic Review. / 02.2020 / PubMed / Full text
Sex Differences in People Aging With HIV. / 01.03.2020 / PubMed / Full text
Identification of Differentially Expressed miRNAs in the Response of Spleen CD4 T Cells to Electroacupuncture in Senescence-Accelerated Mice. / 03.2020 / PubMed / Full text
Thymus Involution and Intravenous Drug Abuse. / 03.2020 / PubMed / Full text
Depletion of CD4 T cells provides therapeutic benefits in aged mice after ischemic stroke. / 04.2020 / PubMed / Full text
Immunological and Virological Responses in Older HIV-Infected Adults Receiving Antiretroviral Therapy: An Evidence-Based Meta-Analysis. / 01.04.2020 / PubMed / Full text
African Mitochondrial DNA Haplogroup L2 Is Associated With Slower Decline of β-cell Function and Lower Incidence of Diabetes Mellitus in Non-Hispanic, Black Women Living With Human Immunodeficiency Virus. / 05.11.2020 / PubMed / Full text
DP1 Activation Reverses Age-Related Hypertension Via NEDD4L-Mediated T-Bet Degradation in T Cells. / 25.02.2020 / PubMed / Full text
An Emerging Concern-High Rates of Frailty among Middle-aged and Older Individuals Living with HIV. / 12.2019 / PubMed / Full text
Higher Acuity Resource Utilization With Older Age and Poorer HIV Control in Adolescents and Young Adults in the HIV Research Network. / 01.04.2020 / PubMed / Full text
Mitochondrial DNA Haplogroups and Frailty in Adults Living with HIV. / 03.2020 / PubMed / Full text
Gallic acid attenuates thymic involution in the d-galactose induced accelerated aging mice. / 01.2020 / PubMed / Full text
Mitochondrial mass governs the extent of human T cell senescence. / 02.2020 / PubMed / Full text
T cells and immune functions of plasma extracellular vesicles are differentially modulated from adults to centenarians. / 27.11.2019 / PubMed / Full text
Defects in Antiviral T Cell Responses Inflicted by Aging-Associated miR-181a Deficiency. / 19.11.2019 / PubMed / Full text
Increased Prevalence of Neurocognitive Impairment in Aging People Living With Human Immunodeficiency Virus: The ANRS EP58 HAND 55-70 Study. / 10.06.2020 / PubMed / Full text
Age-associated changes in human CD4 T cells point to mitochondrial dysfunction consequent to impaired autophagy. / 09.11.2019 / PubMed / Full text
Sex Differences in the Blood Transcriptome Identify Robust Changes in Immune Cell Proportions with Aging and Influenza Infection. / 12.11.2019 / PubMed / Full text
Going Beyond Giving Antiretroviral Therapy: Multimorbidity in Older People Aging with HIV in Nigeria. / 03.2020 / PubMed / Full text
Alterations in composition of immune cells and impairment of anti-tumor immune response in aged oral cancer-bearing mice. / 12.2019 / PubMed / Full text
LTA1 is a safe, intranasal enterotoxin-based adjuvant that improves vaccine protection against influenza in young, old and B-cell-depleted (μMT) mice. / 22.10.2019 / PubMed / Full text
Thymus Imaging Detection and Size Is Inversely Associated With Metabolic Syndrome and Frailty in People With HIV. / 10.2019 / PubMed / Full text
Alterations in peripheral T cell and B cell subsets in patients with osteoarthritis. / 02.2020 / PubMed / Full text
Short Communication: Carotid Intima-Media Thickness Is Not Associated with Neurocognitive Impairment Among People Older than 50 Years With and Without HIV Infection from Thailand. / 11-12.2019 / PubMed / Full text
Implications of Immune Checkpoint Expression During Aging in HIV-Infected People on Antiretroviral Therapy. / 11-12.2019 / PubMed / Full text
Age-related alterations in human gut CD4 T cell phenotype, T helper cell frequencies, and functional responses to enteric bacteria. / 01.2020 / PubMed / Full text
Determinants of blood telomere length in antiretroviral treatment-naïve HIV-positive participants enrolled in the NEAT 001/ANRS 143 clinical trial. / 11.2019 / PubMed / Full text
Human T Cell Differentiation Negatively Regulates Telomerase Expression Resulting in Reduced Activation-Induced Proliferation and Survival. / 2019 / PubMed / Full text
Short Communication: Getting Older with HIV: Increasing Frequency of Comorbidities and Polypharmacy in Brazilian HIV Patients. / 11-12.2019 / PubMed / Full text
Gait Speed Decline Is Associated with Hemoglobin A1C, Neurocognitive Impairment, and Black Race in Persons with HIV. / 11-12.2019 / PubMed / Full text
Noncommunicable Diseases Burden and Risk Factors in a Cohort of HIV+ Elderly Patients in Malawi. / 11-12.2019 / PubMed / Full text
Aging promotes reorganization of the CD4 T cell landscape toward extreme regulatory and effector phenotypes. / 08.2019 / PubMed / Full text
Prevalence of hypertension and cardiovascular risk factors among long-term AIDS survivors: A report from the field. / 10.2019 / PubMed / Full text
Frailty and Its Association with Health Related Quality of Life in Older HIV Patients, in Salvador, Brazil. / 11-12.2019 / PubMed / Full text
The DNA Repair Nuclease MRE11A Functions as a Mitochondrial Protector and Prevents T Cell Pyroptosis and Tissue Inflammation. / 03.09.2019 / PubMed / Full text
Phenotypic Evidence of T Cell Exhaustion and Senescence During Symptomatic [i]Plasmodium falciparum[/i] Malaria. / 2019 / PubMed / Full text
Topological DNA damage, telomere attrition and T cell senescence during chronic viral infections. / 2019 / PubMed / Full text
Blood amyloid-β protein isoforms are affected by HIV-1 in a subtype-dependent pattern. / 02.2020 / PubMed / Full text
Effects of aging, baseline renal function and stage of HIV infection on post-treatment changes in renal function among HIV-infected patients: a retrospective cohort study. / 10.2019 / PubMed / Full text
Metabolic reprogramming in memory CD4 T cell responses of old adults. / 10.2019 / PubMed / Full text
Transcription factor networks in aged naïve CD4 T cells bias lineage differentiation. / 08.2019 / PubMed / Full text
Cost-effectiveness and budget impact of immediate antiretroviral therapy initiation for treatment of HIV infection in Côte d'Ivoire: A model-based analysis. / 2019 / PubMed / Full text
Different sensitivities of senescent breast cancer cells to immune cell-mediated cytotoxicity. / 09.2019 / PubMed / Full text
Biomodulina T partially restores immunosenescent CD4 and CD8 T cell compartments in the elderly. / 09.2019 / PubMed / Full text
Immune senescence and immune activation in elderly colorectal cancer patients. / 13.06.2019 / PubMed / Full text
Cutting Edge: Synapse Propensity of Human Memory CD8 T Cells Confers Competitive Advantage over Naive Counterparts. / 01.08.2019 / PubMed / Full text
Disruption of Telomere Integrity and DNA Repair Machineries by KML001 Induces T Cell Senescence, Apoptosis, and Cellular Dysfunctions. / 2019 / PubMed / Full text
Characterization of IL-17-producing T helper cells-like autoreactive T cells in aged mice. / 06.11.2019 / PubMed / Full text
Sexual dimorphism in rat thymic involution: a correlation with thymic oxidative status and inflammation. / 08.2019 / PubMed / Full text
Increased monocyte activation with age among HIV-infected long term non-progressor children: implications for early treatment initiation. / 09.2019 / PubMed / Full text
Dual faced HMGB1 plays multiple roles in cardiomyocyte senescence and cardiac inflammatory injury. / 06.2019 / PubMed / Full text
Blood lymphocyte subpopulations in healthy water buffaloes (Bubalus bubalis, Mediterranean lineage): Reference intervals and influence of age and reproductive history. / 05.2019 / PubMed / Full text
HIV-infected patients aged above 75years. / 02.2020 / PubMed / Full text
Are skin senescence and immunosenescence linked within individuals? / 08.2019 / PubMed / Full text
Shift of HIV/AIDS Deaths to an Older Age and Gender Difference: Inferences Derived from the Vital Statistics of Japan. / 21.11.2019 / PubMed / Full text
CD4/CD8 ratio predicts the cellular immune response to acute hepatitis C in HIV-coinfected adults. / 08.2019 / PubMed / Full text
Racial Differences in Change in Physical Functioning in Older Male Veterans with HIV. / 11-12.2019 / PubMed / Full text
T cell anergy in perinatal mice is promoted by T reg cells and prevented by IL-33. / 03.06.2019 / PubMed / Full text
Antibody and Memory B Cell Responses in Hepatitis E Recovered Individuals, 1-30 Years Post Hepatitis E Virus Infection. / 11.03.2019 / PubMed / Full text
Expanded peripheral CD4 CD28 T cells and its association with atherosclerotic changes in patients with end stage renal disease on hemodialysis. / 09.2019 / PubMed / Full text
Immunosenescence: the potential role of myeloid-derived suppressor cells (MDSC) in age-related immune deficiency. / 05.2019 / PubMed / Full text
The dynamic association between Frailty, CD4 and CD4/CD8 ratio in people aging with HIV. / 2019 / PubMed / Full text
The New Orleans Alcohol Use in HIV Study: Launching a Translational Investigation of the Interaction of Alcohol Use with Biological and Socioenvironmental Risk Factors for Multimorbidity in People Living with HIV. / 04.2019 / PubMed / Full text
CD56-negative NK cells with impaired effector function expand in CMV and EBV co-infected healthy donors with age. / 27.01.2019 / PubMed / Full text
CXCR6 Inhibits Hepatocarcinogenesis by Promoting Natural Killer T- and CD4 T-Cell-Dependent Control of Senescence. / 05.2019 / PubMed / Full text
Age-associated antigen-presenting cell alterations promote dry-eye inducing Th1 cells. / 07.2019 / PubMed / Full text
Submandibular gland-specific inflammaging-induced hyposalivation in the male senescence-accelerated mouse prone -1 line (SAM-P1). / 08.2019 / PubMed / Full text
Impact of aging on inflammatory and immune responses during elastin peptide-induced murine emphysema. / 01.04.2019 / PubMed / Full text
Magnetic Resonance Imaging of Cerebral Small Vessel Disease in Men Living with HIV and HIV-Negative Men Aged 50 and Above. / 05.2019 / PubMed / Full text
Albumin, white blood cell count, and body mass index improve discrimination of mortality in HIV-positive individuals. / 01.04.2019 / PubMed / Full text
The impact of senescence-associated T cells on immunosenescence and age-related disorders. / 2018 / PubMed / Full text
Post-thymic CD4 positive cytotoxic T cell infiltrates of the skin: A clinical and histomorphologic spectrum of the unique CD4 positive T cell of immunosenescence. / 02.2019 / PubMed / Full text
The Regulatory Status Adopted by Lymph Node Dendritic Cells and T Cells During Healthy Aging Is Maintained During Cancer and May Contribute to Reduced Responses to Immunotherapy. / 2018 / PubMed / Full text
Immune Response-Dependent Assembly of IMP Dehydrogenase Filaments. / 2018 / PubMed / Full text
Correlation of cell-surface CD8 levels with function, phenotype and transcriptome of naive CD8 T cells. / 04.2019 / PubMed / Full text
The poly-omics of ageing through individual-based metabolic modelling. / 20.11.2018 / PubMed / Full text
Effects of pepsin and pepstatin on reflux tonsil hypertrophy in vitro. / 2018 / PubMed / Full text
Increased expression of PD1 and CD39 on CD3 CD4 skin T cells in the elderly. / 01.2019 / PubMed / Full text
CD8 , but not CD4 effector/memory T cells, express the [[CD44]] CD45RB phenotype with aging, which displays reduced expression levels of P2X receptor and ATP-induced cellular responses. / 03.2019 / PubMed / Full text
Heavy Alcohol Use and Age Effects on HIV-Associated Neurocognitive Function. / 01.2019 / PubMed / Full text
Thymic Epithelial Cell Support of Thymopoiesis Does Not Require [i]Klotho[/i]. / 01.12.2018 / PubMed / Full text
Effect of polysaccharides from a Korean ginseng berry on the immunosenescence of aged mice. / 10.2018 / PubMed / Full text
Effects of HIV Infection, methamphetamine dependence and age on cortical thickness, area and volume. / 2018 / PubMed / Full text
Effects of age, HIV, and HIV-associated clinical factors on neuropsychological functioning and brain regional volume in HIV+ patients on effective treatment. / 02.2019 / PubMed / Full text
Changes in the Structure and Cell Composition of Human Carinal Lymph Nodes during Aging. / 09.2018 / PubMed / Full text
CD28 pro-atherogenic CD4 T-cells explain the link between CMV infection and an increased risk of cardiovascular death. / 2018 / PubMed / Full text
Chromogenic Multiplex Immunohistochemistry Reveals Modulation of the Immune Microenvironment Associated with Survival in Elderly Patients with Lung Adenocarcinoma. / 13.09.2018 / PubMed / Full text
Effects of caffeine and phosphodiesterase inhibitors on activation of neonatal T lymphocytes. / 11.2018 / PubMed / Full text
Alterations with age in peripheral blood lymphocyte subpopulations and cytokine synthesis in beagles. / 2012 / PubMed / Full text
Some deterministic and stochastic mathematical models of naïve T-cell homeostasis. / 09.2018 / PubMed / Full text
An imbalance in the T-helper phenotypes displayed by senescent CD4 CD28 T cells is associated with erosive arthritis (rhupus syndrome) in systemic lupus erythematosus. / 11.2018 / PubMed / Full text
The Changing Landscape of Naive T Cell Receptor Repertoire With Human Aging. / 2018 / PubMed / Full text
Altered CD4 T cell immunity in nurses occupationally exposed to viral pathogens. / 11.2018 / PubMed / Full text
Both Granulocytic and Non-Granulocytic Blood Cells Are Affected in Patients with Severe Congenital Neutropenia and Their Non-Neutropenic Family Members: An Evaluation of Morphology, Function, and Cell Death / 13.11.2018 / PubMed / Full text
HIV Persistence on Antiretroviral Therapy and Barriers to a Cure. / 2018 / PubMed / Full text
Inflammatory cytokines and immune system modulation by aerobic versus resisted exercise training for elderly. / 03.2018 / PubMed / Full text
Innate and adaptive immune dysregulation in critically ill ICU patients. / 05.07.2018 / PubMed / Full text
Is Chronic Exposure to Low-Dose Organochlorine Pesticides a New Risk Factor of T-cell Immunosenescence? / 10.2018 / PubMed / Full text
Humanized Mouse Model to Study Type 1 Diabetes. / 09.2018 / PubMed / Full text
Long-term HIV/AIDS survivors: Patients living with HIV infection retained in care for over 20 years. What have we learned? / 11.2018 / PubMed / Full text
Older men display elevated levels of senescence-associated exercise-responsive CD28 angiogenic T cells compared with younger men. / 06.2018 / PubMed / Full text
Association of antiretroviral therapy with brain aging changes among HIV-infected adults. / 10.09.2018 / PubMed / Full text
Changes in alcohol use associated with changes in HIV disease severity over time: A national longitudinal study in the Veterans Aging Cohort. / 01.08.2018 / PubMed / Full text
Enhanced survival of BCG-stimulated dendritic cells: involvement of anti-apoptotic proteins and NF-κB. / 20.06.2018 / PubMed / Full text
Abnormalities of age-related T cell senescence in Parkinson's disease. / 28.05.2018 / PubMed / Full text
Oral Microbiome in HIV-Infected Women: Shifts in the Abundance of Pathogenic and Beneficial Bacteria Are Associated with Aging, HIV Load, CD4 Count, and Antiretroviral Therapy. / 03.2019 / PubMed / Full text
The parasite-derived rOv-ASP-1 is an effective antigen-sparing CD4 T cell-dependent adjuvant for the trivalent inactivated influenza vaccine, and functions in the absence of MyD88 pathway. / 14.06.2018 / PubMed / Full text
Vitamin D levels correlate with lymphocyte subsets in elderly patients with age-related diseases. / 16.05.2018 / PubMed / Full text
Age and CD4 count are dominant factors in the prediction of anaemia in Javanese HIV patients. / 2018 / PubMed / Full text
Effects of Fish Oil on HIV-Related Inflammation and Markers of Immunosenescence: A Randomized Clinical Trial. / 07.2018 / PubMed / Full text
End-stage renal disease, dialysis, kidney transplantation and their impact on CD4 T-cell differentiation. / 10.2018 / PubMed / Full text
Multivariate Analysis of Increase in Life Span of Caenorhabditis elegans Through Intestinal Colonization by Indigenous Probiotic Strains. / 09.2019 / PubMed / Full text
Transcriptional Profiling of Age-Associated Gene Expression Changes in Human Circulatory CD1c+ Myeloid Dendritic Cell Subset. / 01.01.2019 / PubMed / Full text
Impact of Aging on the Frequency, Phenotype, and Function of CD161-Expressing T Cells. / 2018 / PubMed / Full text
Hyper-Expression of PD-1 Is Associated with the Levels of Exhausted and Dysfunctional Phenotypes of Circulating CD161 TCR iVα7.2 Mucosal-Associated Invariant T Cells in Chronic Hepatitis B Virus Infection. / 2018 / PubMed / Full text
The impact of aging on CD4 T cell responses to influenza infection. / 12.2018 / PubMed / Full text
Phenotypic and Functional Changes of Peripheral Ly6C T Regulatory Cells Driven by Conventional Effector T Cells. / 2018 / PubMed / Full text
Differences Between Pediatric and Adult T Cell Responses to [i]In Vitro[/i] Staphylococcal Enterotoxin B Stimulation. / 2018 / PubMed / Full text
Overcoming Barriers of Age to Enhance Efficacy of Cancer Immunotherapy: The Clout of the Extracellular Matrix. / 2018 / PubMed / Full text
Time-restricted feeding influences immune responses without compromising muscle performance in older men. / 07-08.2018 / PubMed / Full text
C-Reactive Protein Impairs Dendritic Cell Development, Maturation, and Function: Implications for Peripheral Tolerance. / 2018 / PubMed / Full text
Senescent T-Cells Promote Bone Loss in Rheumatoid Arthritis. / 2018 / PubMed / Full text
Inclusion body myositis and human immunodeficiency virus type 1: A new case report and literature review. / 04.2018 / PubMed / Full text
Possible correlation between gut microbiota and immunity among healthy middle-aged and elderly people in southwest China. / 2018 / PubMed / Full text
Human blood MAIT cell subsets defined using MR1 tetramers. / 05.2018 / PubMed / Full text
Lupus-like autoimmune disease caused by a lack of Xkr8, a caspase-dependent phospholipid scramblase. / 27.02.2018 / PubMed / Full text
Age-Dependent Pre-Vaccination Immunity Affects the Immunogenicity of Varicella Zoster Vaccination in Middle-aged Adults. / 2018 / PubMed / Full text
Dynamics of CD4 and CD8 T-Cell Subsets and Inflammatory Biomarkers during Early and Chronic HIV Infection in Mozambican Adults. / 2017 / PubMed / Full text
Profiling the lymphoid-resident T cell pool reveals modulation by age and microbiota. / 04.01.2018 / PubMed / Full text
Signal transduction changes in CD4 and CD8 T cell subpopulations with aging. / 05.2018 / PubMed / Full text
Distinctive roles of age, sex, and genetics in shaping transcriptional variation of human immune responses to microbial challenges. / 16.01.2018 / PubMed / Full text
Age-associated alteration in Th17 cell response is related to endothelial cell senescence and atherosclerotic cerebral infarction. / 2017 / PubMed / Full text
Lower resting and exercise-induced circulating angiogenic progenitors and angiogenic T cells in older men. / 01.03.2018 / PubMed / Full text
T-cell differentiation and CD56+ levels in polypoidal choroidal vasculopathy and neovascular age-related macular degeneration. / 20.11.2017 / PubMed / Full text
Enhancement of cutaneous immunity during aging by blocking p38 mitogen-activated protein (MAP) kinase-induced inflammation. / 09.2018 / PubMed / Full text
Increased Echocardiographic Pulmonary Pressure in HIV-infected and -uninfected Individuals in the Veterans Aging Cohort Study. / 01.04.2018 / PubMed / Full text
HIV and Age Do Not Synergistically Affect Age-Related T-Cell Markers. / 01.03.2018 / PubMed / Full text
Differential Relationships among Circulating Inflammatory and Immune Activation Biomediators and Impact of Aging and Human Immunodeficiency Virus Infection in a Cohort of Injection Drug Users. / 2017 / PubMed / Full text
T Follicular Helper Cells and B Cell Dysfunction in Aging and HIV-1 Infection. / 2017 / PubMed / Full text
Attachment and telomere length: more evidence for psychobiological connections between close relationships, health, and aging. / 06.2018 / PubMed / Full text
A Pharmacist-Led Program to Evaluate and Reduce Polypharmacy and Potentially Inappropriate Prescribing in Older HIV-Positive Patients. / 12.2017 / PubMed / Full text
Associations between immunological function and memory recall in healthy adults. / 12.2017 / PubMed / Full text
Reevaluation of immune activation in the era of cART and an aging HIV-infected population. / 19.10.2017 / PubMed / Full text
Cancer-Attributable Mortality Among People With Treated Human Immunodeficiency Virus Infection in North America. / 15.08.2017 / PubMed / Full text
Inhibition of telomerase activity and induction of apoptosis by Rhodospirillum rubrum L-asparaginase in cancer Jurkat cell line and normal human CD4+ T lymphocytes. / 11.2017 / PubMed / Full text
Predictors of transitions in frailty severity and mortality among people aging with HIV. / 2017 / PubMed / Full text
High prevalence of "non-dipping" blood pressure and vascular stiffness in HIV-infected South Africans on antiretrovirals. / 2017 / PubMed / Full text
Altered marginal zone and innate-like B cells in aged senescence-accelerated SAMP8 mice with defective IgG1 responses. / 17.08.2017 / PubMed / Full text

SIRT1

Anthocyanins attenuate endothelial dysfunction through regulation of uncoupling of nitric oxide synthase in aged rats. / 03.12.2020 / PubMed / Full text
Sirtuins and Their Implications in Neurodegenerative Diseases from a Drug Discovery Perspective. / 05.12.2020 / PubMed / Full text
Effects of alpha-mangostin on memory senescence induced by high glucose in human umbilical vein endothelial cells. / 10.2020 / PubMed / Full text
SIRT1 Activation Using CRISPR/dCas9 Promotes Regeneration of Human Corneal Endothelial Cells through Inhibiting Senescence. / 04.11.2020 / PubMed / Full text
Histone Deacetylase SIRT1, Smooth Muscle Cell Function, and Vascular Diseases. / 2020 / PubMed / Full text
6,4'-dihydroxy-7-methoxyflavanone protects against H O -induced cellular senescence by inducing SIRT1 and inhibiting phosphatidylinositol 3-kinase/Akt pathway activation. / 27.10.2020 / PubMed / Full text
Isoparvifuran isolated from Dalbergia odorifera attenuates H O -induced senescence of BJ cells through SIRT1 activation and AKT/mTOR pathway inhibition. / 30.09.2020 / PubMed / Full text
SIRT1 Is the Target Gene for 2,3,5,4'-Tetrahydroxystilbene-2-O-β-D-Glucoside Alleviating the HUVEC Senescence. / 2020 / PubMed / Full text
The Role of Sirtuins in Kidney Diseases. / 12.09.2020 / PubMed / Full text
The effect of 12-week resistance exercise training on serum levels of cellular aging process parameters in elderly men. / 11.2020 / PubMed / Full text
Virus-Induced Asthma Exacerbations: SIRT1 Targeted Approach. / 13.08.2020 / PubMed / Full text
Novel resveratrol derivatives have diverse effects on the survival, proliferation and senescence of primary human fibroblasts. / 12.2020 / PubMed / Full text
Glucose restriction delays senescence and promotes proliferation of HUVECs via the AMPK/SIRT1-FOXA3-Beclin1 pathway. / 01.10.2020 / PubMed / Full text
Therapeutic Effects of SRT2104 on Lung Injury in Rats with Emphysema via Reduction of Type II Alveolar Epithelial Cell Senescence. / 08.2020 / PubMed / Full text
Latifolin Inhibits Oxidative Stress-Induced Senescence via Upregulation of SIRT1 in Human Dermal Fibroblasts. / 01.07.2020 / PubMed / Full text
SRT1720-induced activation of SIRT1 alleviates vascular smooth muscle cell senescence through PKA-dependent phosphorylation of AMPKα at Ser485. / 07.2020 / PubMed / Full text
miR-128 plays a critical role in murine osteoclastogenesis and estrogen deficiency-induced bone loss. / 2020 / PubMed / Full text
Lymphocyte senescence in COPD is associated with decreased sirtuin 1 expression in steroid resistant pro-inflammatory lymphocytes. / 01-12.2020 / PubMed / Full text
Therapeutic effects of hydro-alcoholic leaf extract of Withania somnifera on age-induced changes in daily rhythms of Sirt1, Nrf2 and Rev-erbα in the SCN of male Wistar rats. / 10.2020 / PubMed / Full text
The Serum Concentration of Anti-Aging Proteins, Sirtuin1 and αKlotho in Patients with End-Stage Kidney Disease on Maintenance Hemodialysis. / 2020 / PubMed / Full text
Small extracellular vesicles deliver miR-21 and miR-217 as pro-senescence effectors to endothelial cells. / 2020 / PubMed / Full text
Spatiotemporal gating of SIRT1 functions by O-GlcNAcylation is essential for liver metabolic switching and prevents hyperglycemia. / 24.03.2020 / PubMed / Full text
Hydrogen Sulfide Inhibits Homocysteine-Induced Neuronal Senescence by Up-Regulation of SIRT1. / 2020 / PubMed / Full text
SIRT1 and aging related signaling pathways. / 04.2020 / PubMed / Full text
Tropisetron protects against brain aging via attenuating oxidative stress, apoptosis and inflammation: The role of SIRT1 signaling. / 01.05.2020 / PubMed / Full text
Nicotinamide mononucleotide (NMN) supplementation promotes neurovascular rejuvenation in aged mice: transcriptional footprint of SIRT1 activation, mitochondrial protection, anti-inflammatory, and anti-apoptotic effects. / 04.2020 / PubMed / Full text
Deacetylation of MRTF-A by SIRT1 defies senescence induced down-regulation of collagen type I in fibroblast cells. / 01.05.2020 / PubMed / Full text
Chronic Polyphenon-60 or Catechin Treatments Increase Brain Monoamines Syntheses and Hippocampal SIRT1 Levels Improving Cognition in Aged Rats. / 26.01.2020 / PubMed / Full text
Duck Oil-loaded Nanoemulsion Inhibits Senescence of Angiotensin II-treated Vascular Smooth Muscle Cells by Upregulating SIRT1. / 01.2020 / PubMed / Full text
Two novel SIRT1 activators, SCIC2 and SCIC2.1, enhance SIRT1-mediated effects in stress response and senescence. / 06-07.2020 / PubMed / Full text
Hydrogen sulfide attenuates mitochondrial dysfunction-induced cellular senescence and apoptosis in alveolar epithelial cells by upregulating sirtuin 1. / 23.12.2019 / PubMed / Full text
The protective role of omentin-1 in IL-1β-induced chondrocyte senescence. / 12.2020 / PubMed / Full text
The Lifespan Extension Ability of Nicotinic Acid Depends on Whether the Intracellular NAD Level Is Lower than the Sirtuin-Saturating Concentrations. / 24.12.2019 / PubMed / Full text
Alpha-mangostin decreased cellular senescence in human umbilical vein endothelial cells. / 06.2020 / PubMed / Full text
Central nervous system SIRT1 expression is required for cued and contextual fear conditioning memory responses in aging mice. / 23.09.2019 / PubMed / Full text
Does education level protect us from rapid ageing? Sirtuin expression versus age and level of education. / 10.2019 / PubMed
CO ameliorates endothelial senescence induced by 5-fluorouracil through SIRT1 activation. / 30.11.2019 / PubMed / Full text
Long noncoding RNA GAS5 inhibits cell proliferation and fibrosis in diabetic nephropathy by sponging miR-221 and modulating SIRT1 expression. / 20.10.2019 / PubMed / Full text
The Role of Sirtuin1 in Regulating Endothelial Function, Arterial Remodeling and Vascular Aging. / 2019 / PubMed / Full text
Deacetylation of LAMP1 drives lipophagy-dependent generation of free fatty acids by Abrus agglutinin to promote senescence in prostate cancer. / 03.2020 / PubMed / Full text
Plasma exosomes in OSA patients promote endothelial senescence: effect of long-term adherent continuous positive airway pressure. / 13.02.2020 / PubMed / Full text
Hydrogen Sulfide Inhibits High Glucose-Induced Neuronal Senescence by Improving Autophagic Flux [i]via[/i] Up-regulation of SIRT1. / 2019 / PubMed / Full text
Activation of the miR-34a-Mediated SIRT1/mTOR Signaling Pathway by Urolithin A Attenuates D-Galactose-Induced Brain Aging in Mice. / 10.2019 / PubMed / Full text
[Ginsenoside Rg_1 induces leukemia stem cell senescence via SIRT1/TSC_2 signal axis]. / 06.2019 / PubMed / Full text
miR-23b-3p regulates apoptosis and autophagy via suppressing SIRT1 in lens epithelial cells. / 12.2019 / PubMed / Full text
Genetic background, epigenetic factors and dietary interventions which influence human longevity. / 10.2019 / PubMed / Full text
Adipose-Derived Stem/Stromal Cells Recapitulate Aging Biomarkers and Show Reduced Stem Cell Plasticity Affecting Their Adipogenic Differentiation Capacity. / 08.2019 / PubMed / Full text
Interference with the bromodomain epigenome readers drives p21 expression and tumor senescence. / 01.10.2019 / PubMed / Full text
Involvement of [i]microRNA-34a[/i] in Age-Related Susceptibility to Oxidative Stress in ARPE-19 Cells by Targeting the Silent Mating Type Information Regulation 2 Homolog 1/p66shc Pathway: Implications for Age-Related Macular Degeneration. / 2019 / PubMed / Full text
GPR39 agonist TC-G 1008 ameliorates IL-1β-induced chondrocyte senescence. / 12.2019 / PubMed / Full text
Rational design of novel sirtuin 1 activators via structure-activity insights from application of QSAR modeling. / 2019 / PubMed / Full text
Metformin prevents murine ovarian aging. / 10.06.2019 / PubMed / Full text
Time-restricted feeding delays the emergence of the age-associated, neoplastic-prone tissue landscape. / 12.06.2019 / PubMed / Full text
Myocyte enhancer factor 2A delays vascular endothelial cell senescence by activating the PI3K/p-Akt/SIRT1 pathway. / 10.06.2019 / PubMed / Full text
SIRT1 protects cochlear hair cell and delays age-related hearing loss via autophagy. / 08.2019 / PubMed / Full text
Transcriptome analysis revealed potential mechanisms of differences in physiological stress responses between caged male and female magpies. / 03.06.2019 / PubMed / Full text
Nicotinamide mononucleotide (NMN) treatment attenuates oxidative stress and rescues angiogenic capacity in aged cerebromicrovascular endothelial cells: a potential mechanism for the prevention of vascular cognitive impairment. / 10.2019 / PubMed / Full text
Molecular docking analysis of imine stilbene analogs and evaluation of their anti-aging activity using yeast and mammalian cell models. / 02.2019 / PubMed / Full text
Molecular and Cellular Characterization of SIRT1 Allosteric Activators. / 2019 / PubMed / Full text
Total flavonoids from the Carya cathayensis Sarg. leaves inhibit HUVEC senescence through the miR-34a/SIRT1 pathway. / 10.2019 / PubMed / Full text
Impaired SIRT1 activity leads to diminution in glomerular endowment without accelerating age-associated GFR decline. / 05.2019 / PubMed / Full text
Estrogen-SIRT1 Axis Plays a Pivotal Role in Protecting Arteries Against Menopause-Induced Senescence and Atherosclerosis. / 01.01.2020 / PubMed / Full text
Spatio-temporal expression profile of sirtuins during aging of the annual fish Nothobranchius furzeri. / 09.2019 / PubMed / Full text
Protective effect of vildagliptin on TNF-α-induced chondrocyte senescence. / 07.2019 / PubMed / Full text
Polymorphism rs7895833 in the SIRT1 gene and its association with dyslipidaemia in the elderly. / 07-08.2019 / PubMed / Full text
Modulation of miR-34a/SIRT1 signaling protects cochlear hair cells against oxidative stress and delays age-related hearing loss through coordinated regulation of mitophagy and mitochondrial biogenesis. / 07.2019 / PubMed / Full text
Nicotinamide mononucleotide promotes osteogenesis and reduces adipogenesis by regulating mesenchymal stromal cells via the SIRT1 pathway in aged bone marrow. / 18.04.2019 / PubMed / Full text
Cordycepin, an Active Constituent of Nutrient Powerhouse and Potential Medicinal Mushroom [i]Cordyceps militaris[/i] Linn., Ameliorates Age-Related Testicular Dysfunction in Rats. / 23.04.2019 / PubMed / Full text
The resistant effect of SIRT1 in oxidative stress-induced senescence of rat nucleus pulposus cell is regulated by Akt-FoxO1 pathway. / 31.05.2019 / PubMed / Full text
Photobiomodulation and Coenzyme Q Treatments Attenuate Cognitive Impairment Associated With Model of Transient Global Brain Ischemia in Artificially Aged Mice. / 2019 / PubMed / Full text
The role of SIRT1 in neuroinflammation and cognitive dysfunction in aged rats after anesthesia and surgery. / 2019 / PubMed / Full text
NAD supplementation rejuvenates aged gut adult stem cells. / 06.2019 / PubMed / Full text
NMNAT2-mediated NAD generation is essential for quality control of aged oocytes. / 06.2019 / PubMed / Full text
Mitochondrial dysfunction in neurodegenerative diseases and the potential countermeasure. / 07.2019 / PubMed / Full text
Drugs targeting SIRT1, a new generation of therapeutics for osteoporosis and other bone related disorders? / 05.2019 / PubMed / Full text
Aging, Melatonin, and the Pro- and Anti-Inflammatory Networks. / 11.03.2019 / PubMed / Full text
Knockout of receptor for advanced glycation end-products attenuates age-related renal lesions. / 04.2019 / PubMed / Full text
Stress-induced precocious aging in PD-patient iPSC-derived NSCs may underlie the pathophysiology of Parkinson's disease. / 04.02.2019 / PubMed / Full text
Bone Marrow Mesenchymal Stem Cells-Derived Exosomal MiR-29b-3p Regulates Aging-Associated Insulin Resistance. / 26.02.2019 / PubMed / Full text
Strength training and aerobic exercise alter mitochondrial parameters in brown adipose tissue and equally reduce body adiposity in aged rats. / 02.2019 / PubMed / Full text
Novel biomolecules of ageing, sex differences and potential underlying mechanisms of telomere shortening in coronary artery disease. / 05.2019 / PubMed / Full text
Generation of a novel model of primary human cell senescence through Tenovin-6 mediated inhibition of sirtuins. / 06.2019 / PubMed / Full text
Budesonide, Aclidinium and Formoterol in combination limit inflammaging processes in bronchial epithelial cells exposed to cigarette smoke. / 04.2019 / PubMed / Full text
Relationship between senescence in macaques and bone marrow mesenchymal stem cells and the molecular mechanism. / 23.01.2019 / PubMed / Full text
Protective Role of Endogenous Kallistatin in Vascular Injury and Senescence by Inhibiting Oxidative Stress and Inflammation. / 2018 / PubMed / Full text
NKT-like cells reveal higher than T lymphocytes expression of cellular protective proteins HSP70 and SOD2 and comparably increased expression of SIRT1 in the oldest seniors. / 2018 / PubMed / Full text
Melatonin regulates the activities of ovary and delays the fertility decline in female animals via MT1/AMPK pathway. / 04.2019 / PubMed / Full text
Exercise training augments Sirt1-signaling and attenuates cardiac inflammation in D-galactose induced-aging rats. / 23.12.2018 / PubMed / Full text
Establishment of a Mouse Model of Premature Ovarian Failure Using Consecutive Superovulation. / 2018 / PubMed / Full text
Diesel exhaust exposure intensifies inflammatory and structural changes associated with lung aging in mice. / 15.04.2019 / PubMed / Full text
CD56bright cells respond to stimulation until very advanced age revealing increased expression of cellular protective proteins SIRT1, HSP70 and SOD2. / 2018 / PubMed / Full text
Amentoflavone Induces Autophagy and Modulates p53. / 04.2019 / PubMed / Full text
Induction of a senescent like phenotype and loss of gap junctional intercellular communication by carbon nanoparticle exposure of lung epithelial cells. / 03.2019 / PubMed / Full text
Sirtuins: Developing Innovative Treatments for Aged-Related Memory Loss and Alzheimer's Disease. / 2018 / PubMed / Full text
N-acetylcysteine ameliorates cisplatin-induced renal senescence and renal interstitial fibrosis through sirtuin1 activation and p53 deacetylation. / 01.2019 / PubMed / Full text
Comparing the Effects of Low-Protein and High-Carbohydrate Diets and Caloric Restriction on Brain Aging in Mice. / 20.11.2018 / PubMed / Full text
Metformin Is a Direct SIRT1-Activating Compound: Computational Modeling and Experimental Validation. / 2018 / PubMed / Full text
Hsp90 Stabilizes SIRT1 Orthologs in Mammalian Cells and [i]C. elegans[/i]. / 20.11.2018 / PubMed / Full text
Sirtuins and NAD in the Development and Treatment of Metabolic and Cardiovascular Diseases. / 14.09.2018 / PubMed / Full text
SIRT1 deacetylase in aging-induced neuromuscular degeneration and amyotrophic lateral sclerosis. / 12.2018 / PubMed / Full text
Prevention of Senescence in Vasculature Through Quiescence. / 10.2018 / PubMed / Full text
Melatonin and inflammation-Story of a double-edged blade. / 11.2018 / PubMed / Full text
ALDH2 mediates the dose-response protection of chronic ethanol against endothelial senescence through SIRT1/p53 pathway. / 12.10.2018 / PubMed / Full text
Resveratrol-loaded nanoemulsion prevents cognitive decline after abdominal surgery in aged rats. / 08.2018 / PubMed / Full text
Endothelial SIRT1 prevents age-induced impairment of vasodilator responses by enhancing the expression and activity of soluble guanylyl cyclase in smooth muscle cells. / 01.03.2019 / PubMed / Full text
Effects of Ginsenoside Rg3 on fatigue resistance and SIRT1 in aged rats. / 01.11.2018 / PubMed / Full text
PARP1 inhibitor (PJ34) improves the function of aging-induced endothelial progenitor cells by preserving intracellular NAD levels and increasing SIRT1 activity. / 23.08.2018 / PubMed / Full text
Moderate calorie restriction attenuates age‑associated alterations and improves cardiac function by increasing SIRT1 and SIRT3 expression. / 10.2018 / PubMed / Full text
Liver regeneration in aged mice: new insights. / 28.08.2018 / PubMed / Full text
Phenolic Plant Extracts Induce Sirt1 Activity and Increase Antioxidant Levels in the Rabbit's Heart and Liver. / 2018 / PubMed / Full text
Defect of SIRT1-FoxO3a axis is associated with the production of reactive oxygen species during protein kinase CK2 downregulation-mediated cellular senescence and nematode aging. / 04.2019 / PubMed / Full text
Master athletes have higher miR-7, SIRT3 and SOD2 expression in skeletal muscle than age-matched sedentary controls. / 10.2018 / PubMed / Full text
Tenovin-1 Induces Senescence and Decreases Wound-Healing Activity in Cultured Rat Primary Astrocytes. / 01.05.2019 / PubMed / Full text
PGC-1α Protects RPE Cells of the Aging Retina against Oxidative Stress-Induced Degeneration through the Regulation of Senescence and Mitochondrial Quality Control. The Significance for AMD Pathogenesis. / 07.08.2018 / PubMed / Full text
Effect of oral appliance on circulating leukocyte telomere length and SIRT1 in obstructive sleep apnea. / 03.2019 / PubMed / Full text
miR-34a Promotes Vascular Smooth Muscle Cell Calcification by Downregulating SIRT1 (Sirtuin 1) and Axl (AXL Receptor Tyrosine Kinase). / 09.2018 / PubMed / Full text
A SIRT1-centered circuitry regulates breast cancer stemness and metastasis. / 12.2018 / PubMed / Full text
Apelin/APJ axis improves angiotensin II-induced endothelial cell senescence through AMPK/SIRT1 signaling pathway. / 06.2018 / PubMed / Full text
Sirtuin 1 and Alzheimer's disease: An up-to-date review. / 10.2018 / PubMed / Full text
CCAR-1 is a negative regulator of the heat-shock response in Caenorhabditis elegans. / 10.2018 / PubMed / Full text
Kallistatin attenuates endothelial senescence by modulating Let-7g-mediated miR-34a-SIRT1-eNOS pathway. / 09.2018 / PubMed / Full text
Serum containing Buyang Huanwu decoction prevents age-associated migration and invasion of human vascular smooth muscle cells by up regulating SIRT1 expression. / 17.07.2018 / PubMed / Full text
Role of accelerated aging in limb muscle wasting of patients with COPD. / 2018 / PubMed / Full text
Resveratrol promotes oxidative stress to drive DLC1 mediated cellular senescence in cancer cells. / 15.09.2018 / PubMed / Full text
Mesenchymal stem cells confer resistance to doxorubicin-induced cardiac senescence by inhibiting microRNA-34a. / 06.2018 / PubMed / Full text
The circadian clock in adult neural stem cell maintenance. / 02.2019 / PubMed / Full text
Resveratrol reduces senescence-associated secretory phenotype by SIRT1/NF-κB pathway in gut of the annual fish Nothobranchius guentheri. / 09.2018 / PubMed / Full text
Loss of NAMPT in aging retinal pigment epithelium reduces NAD availability and promotes cellular senescence. / 12.06.2018 / PubMed / Full text
Mushroom extract inhibits ultraviolet B-induced cellular senescence in human keratinocytes. / 06.2018 / PubMed / Full text
SIRT1, miR-132 and miR-212 link human longevity to Alzheimer's Disease. / 31.05.2018 / PubMed / Full text
Endothelial progenitor cells from aged subjects display decreased expression of sirtuin 1, angiogenic functions, and increased senescence. / 09.2018 / PubMed / Full text
Rejuvenating Aged Hematopoietic Stem Cells Through Improvement of Mitochondrial Function. / 09.2018 / PubMed / Full text
Berberine Improves Cognitive Deficiency and Muscular Dysfunction via Activation of the AMPK/SIRT1/PGC-1a Pathway in Skeletal Muscle from Naturally Aging Rats. / 2018 / PubMed / Full text
SIRT1 reverses senescence via enhancing autophagy and attenuates oxidative stress-induced apoptosis through promoting p53 degradation. / 01.10.2018 / PubMed / Full text
Loss of sirtuin 1 and mitofusin 2 contributes to enhanced ischemia/reperfusion injury in aged livers. / 08.2018 / PubMed / Full text
Dietary polyphenols and neurogenesis: Molecular interactions and implication for brain ageing and cognition. / 07.2018 / PubMed / Full text
Whey Protein Attenuates Angiotensin II-Primed Premature Senescence of Vascular Smooth Muscle Cells through Upregulation of SIRT1. / 2017 / PubMed / Full text
Role of hypothalamus in aging and its underlying cellular mechanisms. / 01.2019 / PubMed / Full text
The variable role of SIRT1 in the maintenance and differentiation of mesenchymal stem cells. / 04.2018 / PubMed / Full text
Sirtuins in Renal Health and Disease. / 07.2018 / PubMed / Full text
Physical Exercise Improves Aging-Related Changes in Angiotensin, IGF-1, SIRT1, SIRT3, and VEGF in the Substantia Nigra. / 10.11.2018 / PubMed / Full text
MeCP2-mediated epigenetic regulation in senescent endothelial progenitor cells. / 03.04.2018 / PubMed / Full text
Natural products with anti-aging potential: Affected targets and molecular mechanisms. / 01.11.2018 / PubMed / Full text
[Effect of microRNA-34a/SIRT1/p53 signal pathway on notoginsenoside R₁ delaying vascular endothelial cell senescence]. / 02.2018 / PubMed / Full text
SIRT1 and microRNAs: The role in breast, lung and prostate cancers. / 01.06.2018 / PubMed / Full text
Leukotriene D4 induces cellular senescence in osteoblasts. / 05.2018 / PubMed / Full text
Impairment of an Endothelial NAD -H S Signaling Network Is a Reversible Cause of Vascular Aging. / 22.03.2018 / PubMed / Full text
Differential gene expression of sirtuins between somatotropinomas and nonfunctioning pituitary adenomas. / 08.2018 / PubMed / Full text
Nicotinamide Improves Aspects of Healthspan, but Not Lifespan, in Mice. / 06.03.2018 / PubMed / Full text
Role of Sirtuin1-p53 regulatory axis in aging, cancer and cellular reprogramming. / 05.2018 / PubMed / Full text
HGF and BFGF Secretion by Human Adipose-Derived Stem Cells Improves Ovarian Function During Natural Aging via Activation of the SIRT1/FOXO1 Signaling Pathway. / 2018 / PubMed / Full text
The protective effect of resveratrol on vascular aging by modulation of the renin-angiotensin system. / 03.2018 / PubMed / Full text
Metformin regulates mitochondrial biogenesis and senescence through AMPK mediated H3K79 methylation: Relevance in age-associated vascular dysfunction. / 04.2018 / PubMed / Full text
Antagonism of cysteinyl leukotriene receptor 1 (cysLTR1) by montelukast suppresses cell senescence of chondrocytes. / 03.2018 / PubMed / Full text
Gut flora-dependent metabolite Trimethylamine-N-oxide accelerates endothelial cell senescence and vascular aging through oxidative stress. / 20.02.2018 / PubMed / Full text
Resveratrol, an Nrf2 activator, ameliorates aging-related progressive renal injury. / 11.01.2018 / PubMed / Full text
Acetylshikonin from Zicao attenuates cognitive impairment and hippocampus senescence in d-galactose-induced aging mouse model via upregulating the expression of SIRT1. / 03.2018 / PubMed / Full text
Dexamethasone downregulates SIRT1 and IL6 and upregulates EDN1 genes in stem cells derived from gingivae via the AGE/RAGE pathway. / 03.2018 / PubMed / Full text
Sirtuins in Brain Aging and Neurological Disorders. / 2017 / PubMed / Full text
[Aging-related change of erectile function and the expression of SIRT1]. / 12.2016 / PubMed
Expression of Sirtuins in the Retinal Neurons of Mice, Rats, and Humans. / 2017 / PubMed / Full text
Maternal aging affects oocyte resilience to carbonyl cyanide-m-chlorophenylhydrazone -induced mitochondrial dysfunction in cows. / 2017 / PubMed / Full text
Nicotinamide phosphoribosyltransferase delays cellular senescence by upregulating SIRT1 activity and antioxidant gene expression in mouse cells. / 12.2017 / PubMed / Full text
Stem Cells and Progenitors in Human Peripheral Blood Get Activated by Extremely Active Resveratrol (XAR™). / 04.2018 / PubMed / Full text
Fibroblast growth factor 21 delayed endothelial replicative senescence and protected cells from H O -induced premature senescence through SIRT1. / 2017 / PubMed / Full text
Tucum-do-Cerrado (Bactris setosa Mart.) May Promote Anti-Aging Effect by Upregulating SIRT1-Nrf2 Pathway and Attenuating Oxidative Stress and Inflammation. / 14.11.2017 / PubMed / Full text
Maternal high calorie diet induces mitochondrial dysfunction and senescence phenotype in subcutaneous fat of newborn mice. / 13.10.2017 / PubMed / Full text
O-GlcNAcylation of SIRT1 enhances its deacetylase activity and promotes cytoprotection under stress. / 14.11.2017 / PubMed / Full text
Aging as an Epigenetic Phenomenon. / 10.2017 / PubMed / Full text
MeCP2 mediated dysfunction in senescent EPCs. / 03.10.2017 / PubMed / Full text
Role of Beta-adrenergic Receptors and Sirtuin Signaling in the Heart During Aging, Heart Failure, and Adaptation to Stress. / 01.2018 / PubMed / Full text
A comparative study of anti-aging properties and mechanism: resveratrol and caloric restriction. / 12.09.2017 / PubMed / Full text
Small molecule modulation of splicing factor expression is associated with rescue from cellular senescence. / 17.10.2017 / PubMed / Full text
Negative regulation of Sirtuin 1 by AMP-activated protein kinase promotes metformin-induced senescence in hepatocellular carcinoma xenografts. / 28.12.2017 / PubMed / Full text
Blocking SIRT1 inhibits cell proliferation and promotes aging through the PI3K/AKT pathway. / 01.12.2017 / PubMed / Full text
SIRT1 is a positive regulator of in vivo bone mass and a therapeutic target for osteoporosis. / 2017 / PubMed / Full text
[Protective effect of total saponins of Panax notoginseng combined with total flavonoids of epimedium on D-galactose-incuced senescence of H9c2 cell]. / 02.2017 / PubMed / Full text
SIRT1 is a transcriptional enhancer of the glucocorticoid receptor acting independently to its deacetylase activity. / 05.02.2018 / PubMed / Full text
G protein-coupled receptor kinase 4-induced cellular senescence and its senescence-associated gene expression profiling. / 15.11.2017 / PubMed / Full text
The effect of exercise, resveratrol or their combination on Sarcopenia in aged rats via regulation of AMPK/Sirt1 pathway. / 11.2017 / PubMed / Full text
Chronic Silymarin, Quercetin and Naringenin Treatments Increase Monoamines Synthesis and Hippocampal Sirt1 Levels Improving Cognition in Aged Rats. / 03.2018 / PubMed / Full text
Aquatide Activation of SIRT1 Reduces Cellular Senescence through a SIRT1-FOXO1-Autophagy Axis. / 01.09.2017 / PubMed / Full text
Obesity and aging diminish sirtuin 1 (SIRT1)-mediated deacetylation of SIRT3, leading to hyperacetylation and decreased activity and stability of SIRT3. / 20.10.2017 / PubMed / Full text
Circadian Reprogramming in the Liver Identifies Metabolic Pathways of Aging. / 10.08.2017 / PubMed / Full text
High glucose and free fatty acids induce endothelial progenitor cell senescence via PGC-1α/SIRT1 signaling pathway. / 10.2017 / PubMed / Full text

HR

Patients with hip fracture and total hip arthroplasty surgery differ in anthropometric, but not cardiovascular screening abnormalities. / 02.12.2020 / PubMed / Full text
Clinical Role of Lung Ultrasound for the Diagnosis and Prognosis of Coronavirus Disease Pneumonia in Elderly Patients: A Pivotal Study. / 03.12.2020 / PubMed / Full text
The Relationship of Accelerometer-Assessed Standing Time With and Without Ambulation and Mortality: The WHI OPACH Study. / 12.10.2020 / PubMed / Full text
Age-related myofiber atrophy in old mice is reversed by ten weeks voluntary high-resistance wheel running. / 09.11.2020 / PubMed / Full text
Predicted Skeletal Muscle Mass and 4-Year Cardiovascular Disease Incidence in Middle-Aged and Elderly Participants of IKARIA Prospective Epidemiological Study: The Mediating Effect of Sex and Cardiometabolic Factors. / 27.10.2020 / PubMed / Full text
Obesity is associated with early hip fracture risk in postmenopausal women: a 25-year follow-up. / 23.10.2020 / PubMed / Full text
ATM inhibition synergizes with fenofibrate in high grade serous ovarian cancer cells. / 09.2020 / PubMed / Full text
Effectiveness of adjuvant FOLFOX vs 5FU/LV in adults over age 65 with stage II and III colon cancer using a novel hybrid approach. / 12.2020 / PubMed / Full text
Age, Frailty, and Comorbidity as Prognostic Factors for Short-Term Outcomes in Patients With Coronavirus Disease 2019 in Geriatric Care. / 11.2020 / PubMed / Full text
Clinical and demographic parameters predict the progression from mild cognitive impairment to dementia in elderly patients. / 12.09.2020 / PubMed / Full text
Plasma Dehydroepiandrosterone Sulfate and Cardiovascular Disease Risk in Older Men and Women. / 01.12.2020 / PubMed / Full text
High intensity interval training combined with L-citrulline supplementation: Effects on physical performance in healthy older adults. / 15.10.2020 / PubMed / Full text
Associations of blood pressure with risk of injurious falls in old age vary by functional status: A cohort study. / 15.10.2020 / PubMed / Full text
Epigenetic age acceleration and clinical outcomes in gliomas. / 2020 / PubMed / Full text
Do Stairs Inhibit Seniors Who Live on Upper Floors From Going Out? / 10.2020 / PubMed / Full text
Age-specific acute changes in carotid-femoral pulse wave velocity with head-up tilt. / 07.07.2020 / PubMed / Full text
Pre-frailty status increases the risk of rehospitalization in patients after elective cardiac surgery without complication. / 06.2020 / PubMed / Full text
Comparative Performance of Creatinine-Based GFR Estimation Equations in Exceptional Longevity: The Rugao Longevity and Ageing Study. / 2020 / PubMed / Full text
Sex-and race-specific associations of protein intake with change in muscle mass and physical function in older adults: the Health, Aging, and Body Composition (Health ABC) Study. / 01.07.2020 / PubMed / Full text
Deterioration of bone microstructure by aging and menopause in Japanese healthy women: analysis by HR-pQCT. / 11.2020 / PubMed / Full text
Association between Low Protein Intake and Mortality in Patients with Type 2 Diabetes. / 01.06.2020 / PubMed / Full text
CAUSES, mortality rates and risk factors of death in community-dwelling Europeans aged 50 years and over: Results from the Survey of Health, Ageing and Retirement in Europe 2013-2015. / 07-08.2020 / PubMed / Full text
Estimation of Wave Condition Number From Pressure Waveform Alone and Its Changes With Advancing Age in Healthy Women and Men. / 2020 / PubMed / Full text
Extended in vitro culture of primary human mesenchymal stem cells downregulates Brca1-related genes and impairs DNA double-strand break recognition. / 07.2020 / PubMed / Full text
Effect of artificial dawn light on cardiovascular function, alertness, and balance in middle-aged and older adults. / 13.10.2020 / PubMed / Full text
Heart Rate Performance Curve Is Dependent on Age, Sex, and Performance. / 2020 / PubMed / Full text
Physical activity trajectories, mortality, hospitalization, and disability in the Toledo Study of Healthy Aging. / 08.2020 / PubMed / Full text
U-Shaped Association of Plasma Testosterone, and no Association of Plasma Estradiol, with Incidence of Fractures in Men. / 01.05.2020 / PubMed / Full text
Pregnancy-Related Bone Mineral and Microarchitecture Changes in Women Aged 30 to 45 Years. / 07.2020 / PubMed / Full text
Analysis of the world record time for combined father and son marathon. / 01.02.2020 / PubMed / Full text
Age-related reductions in heart rate variability do not worsen during exposure to humid compared to dry heat: A secondary analysis. / 2019 / PubMed / Full text
Efficacy and Safety of Dapagliflozin in the Elderly: Analysis From the DECLARE-TIMI 58 Study. / 02.2020 / PubMed / Full text
Validity of Prediction Equations of Maximal Heart Rate in Physically Active Female Adolescents and the Role of Maturation. / 13.11.2019 / PubMed / Full text
Base excision repair but not DNA double-strand break repair is impaired in aged human adipose-derived stem cells. / 02.2020 / PubMed / Full text
Urban-Rural Differences in Hip Fracture Mortality: A Nationwide NOREPOS Study. / 11.2019 / PubMed / Full text
Malnutrition as a Strong Predictor of the Onset of Sarcopenia. / 27.11.2019 / PubMed / Full text
Acclimation to a thermoneutral environment abolishes age-associated alterations in heart rate and heart rate variability in conscious, unrestrained mice. / 02.2020 / PubMed / Full text
Long-term dementia risk prediction by the LIBRA score: A 30-year follow-up of the CAIDE study. / 02.2020 / PubMed / Full text
Kidney function and its association to imminent, short- and long-term fracture risk-a longitudinal study in older women. / 01.2020 / PubMed / Full text
Oxidatively Damaged DNA/RNA and 8-Isoprostane Levels Are Associated With the Development of Type 2 Diabetes at Older Age: Results From a Large Cohort Study. / 01.2020 / PubMed / Full text
Associations of vigorous physical activity with all-cause, cardiovascular and cancer mortality among 64 913 adults. / 2019 / PubMed / Full text
Reduced cerebrovascular and cardioventilatory responses to intermittent hypoxia in elderly. / 01.2020 / PubMed / Full text
Vestibulo-sympathetic reflex in patients with bilateral vestibular loss. / 01.11.2019 / PubMed / Full text
Heart rate and blood pressure in male Ts65Dn mice: a model to investigate cardiovascular responses in Down syndrome. / 09.2019 / PubMed / Full text
Body weight at 10 years of age and change in body composition between 8 and 10 years of age were related to survival in a longitudinal study of 39 Labrador retriever dogs. / 09.09.2019 / PubMed / Full text
Dietary diversity offsets the adverse mortality risk among older indigenous Taiwanese. / 2019 / PubMed / Full text
Independent and joint effects of vascular and cardiometabolic risk factor pairs for risk of all-cause dementia: a prospective population-based study. / 10.2019 / PubMed / Full text
Work Ability and Job Survival: Four-Year Follow-Up. / 28.08.2019 / PubMed / Full text
Predictivity of bioimpedance phase angle for incident disability in older adults. / 02.2020 / PubMed / Full text
Diet Quality Is Associated With Mortality in Adults Aged 80 Years and Older: A Prospective Study. / 10.2019 / PubMed / Full text
Birthweight in offspring and cardiovascular mortality in their parents, aunts and uncles: a family-based cohort study of 1.35 million births. / 01.02.2020 / PubMed / Full text
Younger- vs Older-Old Patients with Heart Failure with Preserved Ejection Fraction. / 10.2019 / PubMed / Full text
Comparison of Immune Checkpoint Inhibitors between Older and Younger Patients with Advanced or Metastatic Lung Cancer: A Systematic Review and Meta-Analysis. / 2019 / PubMed / Full text
Physical activity, multimorbidity, and life expectancy: a UK Biobank longitudinal study. / 12.06.2019 / PubMed / Full text
Fed and fasted states on heart rate variability, hemodynamic heart rate and blood pressure in adults submitted to moderate aerobic exercise. / 06.2019 / PubMed / Full text
Structure Characterization and Action Mechanism of an Antiaging New Compound from [i]Gastrodia elata[/i] Blume. / 2019 / PubMed / Full text
Effects of Whole-Body Vibration Therapy on Distal Tibial Myotendinous Density and Volume: A Randomized Controlled Trial in Postmenopausal Women. / 05.2019 / PubMed / Full text
Smoking cessation and risk of recurrent cardiovascular events and mortality after a first manifestation of arterial disease. / 07.2019 / PubMed / Full text
The Association of Aromatic Amino Acids with Incident Hip Fracture, aBMD, and Body Composition from the Cardiovascular Health Study. / 08.2019 / PubMed / Full text
Impact of handgrip strength on cardiovascular, cancer and all-cause mortality in the Korean longitudinal study of ageing. / 09.05.2019 / PubMed / Full text
Vitamin K Status and Mobility Limitation and Disability in Older Adults: The Health, Aging, and Body Composition Study. / 09.03.2020 / PubMed / Full text
Effects of a clinical medication review focused on personal goals, quality of life, and health problems in older persons with polypharmacy: A randomised controlled trial (DREAMeR-study). / 05.2019 / PubMed / Full text
PML nuclear bodies are recruited to persistent DNA damage lesions in an RNF168-53BP1 dependent manner and contribute to DNA repair. / 06.2019 / PubMed / Full text
Relationship Between Sex Steroids and Deterioration of Bone Microarchitecture in Older Men: The Prospective STRAMBO Study. / 09.2019 / PubMed / Full text
Sex And Prognostic Significance of Self-Reported Frailty in Non-ST-Segment Elevation Acute Coronary Syndromes: Insights From the TRILOGY ACS Trial. / 04.2019 / PubMed / Full text
Plasma 25-Hydroxyvitamin D Concentrations Are Inversely Associated with All-Cause Mortality among a Prospective Cohort of Chinese Adults Aged ≥80 Years. / 01.06.2019 / PubMed / Full text
Sex-specific associations between body mass index and death before life expectancy: a comparative study from the USA and Sweden. / 2019 / PubMed / Full text
Correlation between patients' age and cancer immunotherapy efficacy. / 2019 / PubMed / Full text
Understanding the responsiveness of nitric oxide to acute eccentric resistance exercise in elderly obese women. / 20.06.2016 / PubMed / Full text
Age-dependent changes in metabolite profile and lipid saturation in dystrophic mice. / 05.2019 / PubMed / Full text
Investigating dose-response effects of multimodal exercise programs on health-related quality of life in older adults. / 2019 / PubMed / Full text
Methylation-Based Biological Age and Breast Cancer Risk. / 01.10.2019 / PubMed / Full text
Prospective association between adherence to the MIND diet and subjective memory complaints in the French NutriNet-Santé cohort. / 04.2019 / PubMed / Full text
Relationship between physical and cognitive performance in community dwelling, ethnically diverse older adults: a cross-sectional study. / 2019 / PubMed / Full text
Associations of Hearing Loss and Depressive Symptoms With Incident Disability in Older Adults: Health, Aging, and Body Composition Study. / 14.02.2020 / PubMed / Full text
Effects of a 12-Week Aerobic Spin Intervention on Resting State Networks in Previously Sedentary Older Adults. / 2018 / PubMed / Full text
Erythrocyte sedimentation rate as an independent prognostic marker for mortality: a prospective population-based cohort study. / 03.2019 / PubMed / Full text
Moderate Aerobic Training Decreases Blood Pressure but No Other Cardiovascular Risk Factors in Hypertensive Overweight/Obese Elderly Patients. / 01-12.2018 / PubMed / Full text
The burden of common variable immunodeficiency disorders: a retrospective analysis of the European Society for Immunodeficiency (ESID) registry data. / 12.11.2018 / PubMed / Full text
Survival after non-traumatic spinal cord injury: evidence from a population-based rehabilitation cohort in Switzerland. / 04.2019 / PubMed / Full text
Is there a correlation between an eGFR slope measured over a 5-year period and incident cardiovascular events in the following 5 years among a Flemish general practice population: a retrospective cohort study. / 12.11.2018 / PubMed / Full text
Biphasic concentration-dependent interaction between imidacloprid and dietary phytochemicals in honey bees (Apis mellifera). / 2018 / PubMed / Full text
Heart rate variability in middle-aged sprint and endurance athletes. / 01.06.2019 / PubMed / Full text
Serum cystatin C, impaired kidney function, and geriatric depressive symptoms among older people living in a rural area: a population-based study. / 06.11.2018 / PubMed / Full text
Office and Ambulatory Heart Rate as Predictors of Age-Related Kidney Function Decline. / 09.2018 / PubMed / Full text
Aging Alters the Relative Contributions of the Sympathetic and Parasympathetic Nervous System to Blood Pressure Control in Women. / 11.2018 / PubMed / Full text
Association between treatment of superficial bladder cancer and 10-year mortality in older adults with multiple chronic conditions. / 01.12.2018 / PubMed / Full text
Conjoint differences in inhibitory control and processing speed in childhood to older adult cohorts: Discriminant functions from a Go/No-Go task. / 11.2018 / PubMed / Full text
Heart Rate Fragmentation as a Novel Biomarker of Adverse Cardiovascular Events: The Multi-Ethnic Study of Atherosclerosis. / 2018 / PubMed / Full text
Partial nephrectomy is not associated with an overall survival advantage over radical nephrectomy in elderly patients with stage Ib-II renal masses: An analysis of the national cancer data base. / 01.10.2018 / PubMed / Full text
Uraemia-induced immune senescence and clinical outcomes in chronic kidney disease patients. / 01.04.2020 / PubMed / Full text
Cognitive functioning transitions, health expectancies, and inequalities among elderly people in China: A nationwide longitudinal study. / 12.2018 / PubMed / Full text
Diurnal rhythms of heart and respiratory rates in donkeys of different age groups during the cold-dry and hot-dry seasons in a tropical savannah. / 09.2018 / PubMed / Full text
Absolute 10-year risk of dementia by age, sex and [i]APOE[/i] genotype: a population-based cohort study. / 04.09.2018 / PubMed / Full text
Testosterone Levels and Type 2 Diabetes-No Correlation with Age, Differential Predictive Value in Men and Women. / 20.08.2018 / PubMed / Full text
Vegetable Diversity, Injurious Falls, and Fracture Risk in Older Women: A Prospective Cohort Study. / 13.08.2018 / PubMed / Full text
Evidence of oxidative stress-induced senescence in mature, post-mature and pathological human placentas. / 08.2018 / PubMed / Full text
Enoch Senior's College for Korean Immigrant Seniors: Quality of Life Effects. / 09.2018 / PubMed / Full text
Non-AIDS Mortality Is Higher Among Successfully Treated People Living with HIV Compared with Matched HIV-Negative Control Persons: A 15-Year Follow-Up Cohort Study in Sweden. / 08.2018 / PubMed / Full text
Gain without pain: Glucose promotes cognitive engagement and protects positive affect in older adults. / 08.2018 / PubMed / Full text
Ten-year changes in ambulatory blood pressure: The prognostic value of ambulatory pulse pressure. / 09.2018 / PubMed / Full text
Impact of Low Cardiovascular Risk Profiles on Geriatric Outcomes: Evidence From 421,000 Participants in Two Cohorts. / 15.02.2019 / PubMed / Full text
Supplementation with resveratrol as Polygonum cuspidatum Sieb. et Zucc. extract induces changes in the excretion of urinary markers associated to aging in rats. / 09.2018 / PubMed / Full text
Subjective cognitive decline and risk of MCI: The Mayo Clinic Study of Aging. / 24.07.2018 / PubMed / Full text
Maternal gene [i]Ooep[/i] may participate in homologous recombination-mediated DNA double-strand break repair in mouse oocytes. / 18.11.2018 / PubMed / Full text
Progression of frailty and prevalence of osteoporosis in a community cohort of older women-a 10-year longitudinal study. / 10.2018 / PubMed / Full text
Higher spermidine intake is linked to lower mortality: a prospective population-based study. / 01.08.2018 / PubMed / Full text
Childhood IQ and mortality during 53 years' follow-up of Swedish men and women. / 10.2018 / PubMed / Full text
Age-related changes in cardiac electrophysiology and calcium handling in response to sympathetic nerve stimulation. / 09.2018 / PubMed / Full text
Physical activity and sedentary behavior in relation to mortality among renal cell cancer survivors. / 2018 / PubMed / Full text
Increased CAIDE dementia risk, cognition, CSF biomarkers, and vascular burden in healthy adults. / 17.07.2018 / PubMed / Full text
Associations Between Heart Rate Recovery Dynamics With Estradiol Levels in 20 to 60 Year-Old Sedentary Women. / 2018 / PubMed / Full text
Prognostic value of age adjusted segment involvement score as measured by coronary computed tomography: a potential marker of vascular age. / 11.2018 / PubMed / Full text
The Acute Effects of Age and Particulate Matter Exposure on Heart Rate and Heart Rate Variability in Mice. / 12.2018 / PubMed / Full text
Neuroticism predicts all-cause mortality over 19-years: The moderating effects on functional status, and the angiotensin-converting enzyme. / 07.2018 / PubMed / Full text
Anxiety and 10-Year Risk of Incident Dementia-An Association Shaped by Depressive Symptoms: Results of the Prospective Three-City Study. / 2018 / PubMed / Full text
Delirium as a predictor of mortality in US Medicare beneficiaries discharged from the emergency department: a national claims-level analysis up to 12 months. / 05.05.2018 / PubMed / Full text
Prognostic value of cardiac troponin I assay in hospitalized elderly patients. / 02.2019 / PubMed / Full text
The influence of participation on mortality in very old age among community-living people in Sweden. / 02.2019 / PubMed / Full text
Mediterranean diet and hip fracture incidence among older adults: the CHANCES project. / 07.2018 / PubMed / Full text
Depression in type 1 diabetes and risk of dementia. / 07.2019 / PubMed / Full text
Testosterone and All-Cause Mortality in Older Men: The Role of Metabolic Syndrome. / 01.04.2018 / PubMed / Full text
Arterial stiffening is a heritable trait associated with arterial dilation but not wall thickening: a longitudinal study in the twins UK cohort. / 21.06.2018 / PubMed / Full text
Pulmonary Hypertension in Central Australia: A Community-Based Cohort Study. / 04.2019 / PubMed / Full text
The application of the palliative prognostic index in predicting the life expectancy of patients in palliative care: a systematic review and meta-analysis. / 12.2018 / PubMed / Full text
Weight loss in men in late life and bone strength and microarchitecture: a prospective study. / 07.2018 / PubMed / Full text
[The life span of red blood cell in patients with severe/very severe aplastic anemia]. / 14.02.2018 / PubMed / Full text
Dairy product consumption and its association with metabolic disturbance in a prospective study of urban adults. / 03.2018 / PubMed / Full text
Factors associated with polypharmacy in primary care: a cross-sectional analysis of data from The English Longitudinal Study of Ageing (ELSA). / 14.03.2018 / PubMed / Full text
Do Patients Live Longer After THA and Is the Relative Survival Diagnosis-specific? / 06.2018 / PubMed / Full text
The relationship between excessive daytime sleepiness, disability, and mortality, and implications for life expectancy. / 03.2018 / PubMed / Full text
Long-Term Atherosclerotic Vascular Disease Risk and Prognosis in Elderly Women With Abdominal Aortic Calcification on Lateral Spine Images Captured During Bone Density Testing: A Prospective Study. / 06.2018 / PubMed / Full text
Age-related changes in with-the-rule and oblique corneal astigmatism. / 09.2018 / PubMed / Full text
Ageing perceptions and non-adherence to aromatase inhibitors among breast cancer survivors. / 03.2018 / PubMed / Full text
The prospective and concurrent effect of exercise on health related quality of life in older adults over a 3 year period. / 16.01.2018 / PubMed / Full text
Utility of Time and Frequency Domain Parameters of Heart Rate Variability in the Context of Autonomic Disorders Characterized by Orthostatic Dysfunction. / 03.2018 / PubMed / Full text
Association Between Heart Rate and Subclinical Cerebrovascular Disease in the Elderly. / 02.2018 / PubMed / Full text
An additive effect of leading role in the organization between social participation and dementia onset among Japanese older adults: the AGES cohort study. / 29.12.2017 / PubMed / Full text
Replication Stress Shapes a Protective Chromatin Environment across Fragile Genomic Regions. / 04.01.2018 / PubMed / Full text
Metabolites Associated With Risk of Developing Mobility Disability in the Health, Aging and Body Composition Study. / 01.01.2019 / PubMed / Full text
Which Sleep Health Characteristics Predict All-Cause Mortality in Older Men? An Application of Flexible Multivariable Approaches. / 01.01.2018 / PubMed / Full text
Social isolation, health literacy, and mortality risk: Findings from the English Longitudinal Study of Ageing. / 02.2018 / PubMed / Full text
Bone Loss at the Hip and Subsequent Mortality in Older Men: The Osteoporotic Fractures in Men (MrOS) Study. / 08.2017 / PubMed / Full text
Thyroid status and mortality in nonagenarians from long-lived families and the general population. / 25.10.2017 / PubMed / Full text
Frailty index as a predictor of mortality: a systematic review and meta-analysis. / 01.03.2018 / PubMed / Full text
Trajectories of IGF-I Predict Mortality in Older Adults: The Cardiovascular Health Study. / 14.06.2018 / PubMed / Full text
Is orthostatic hypotension more common in individuals with atrial fibrillation?-Findings from The Irish Longitudinal Study on Ageing (TILDA). / 01.11.2017 / PubMed / Full text
Subjective life expectancy is a risk factor for perceived health status and mortality. / 02.10.2017 / PubMed / Full text
The effects of dexmedetomidine preconditioning on aged rat heart of ischaemia reperfusion injury. / 10.2017 / PubMed / Full text
Diabetes and Deficits in Cortical Bone Density, Microarchitecture, and Bone Size: Framingham HR-pQCT Study. / 01.2018 / PubMed / Full text
Gender differences in longevity in free-living older adults who eat-with-others: a prospective study in Taiwan. / 18.09.2017 / PubMed / Full text
Decline in effort capacity with age: Echocardiographic stress analysis in the elderly. / 12.2017 / PubMed / Full text
Impaired disengagement of attention and its relationship to emotional distress in infants at high-risk for autism spectrum disorder. / 06.2018 / PubMed / Full text
Statins for Primary Prevention of Cardiovascular Events and Mortality in Older Men. / 11.2017 / PubMed / Full text
Galectin-3 and risk of ischaemic stroke: Reasons for Geographic and Racial Differences in Stroke cohort. / 12.2017 / PubMed / Full text
Sleep duration, mortality and the influence of age. / 10.2017 / PubMed / Full text
Comparison of yoga and walking-exercise on cardiac time intervals as a measure of cardiac function in elderly with increased pulse pressure. / 07-08.2017 / PubMed / Full text
Dietary acid load and renal function have varying effects on blood acid-base status and exercise performance across age and sex. / 12.2017 / PubMed / Full text
Elite Distance Runners: A 45-Year Follow-up. / 01.2018 / PubMed / Full text
Short-term water-based aerobic training promotes improvements in aerobic conditioning parameters of mature women. / 08.2017 / PubMed / Full text

APOE

Polygenic risk score of longevity predicts longer survival across an age-continuum. / 20.11.2020 / PubMed / Full text
Association Between APOE Alleles and Change of Neuropsychological Tests in the Long Life Family Study. / 17.11.2020 / PubMed / Full text
The APOE gene cluster responds to air pollution factors in mice with coordinated expression of genes that differs by age in humans. / 20.11.2020 / PubMed / Full text
Homozygosity in the [i]APOE[/i] 3 Polymorphism Is Associated With Less Depression and Higher Serum Low-Density Lipoprotein in Chinese Elderly Schizophrenics. / 2020 / PubMed / Full text
Effect of apolipoprotein E polymorphism on cognition and brain in the Cambridge Centre for Ageing and Neuroscience cohort. / 01-12.2020 / PubMed / Full text
Cardiovascular risk factors and APOE-ε4 status affect memory functioning in aging via changes to temporal stem diffusion. / 18.10.2020 / PubMed / Full text
APOE [i]ε[/i]4 and resting-state functional connectivity in racially/ethnically diverse older adults. / 2020 / PubMed / Full text
Predictors of Olfactory Decline in Aging: A Longitudinal Population-Based Study. / 13.11.2020 / PubMed / Full text
When Culture Influences Genes: Positive Age Beliefs Amplify the Cognitive-Aging Benefit of APOE ε2. / 14.09.2020 / PubMed / Full text
Age and the association between apolipoprotein E genotype and Alzheimer disease: A cerebrospinal fluid biomarker-based case-control study. / 08.2020 / PubMed / Full text
Estimating the potential for dementia prevention through modifiable risk factors elimination in the real-world setting: a population-based study. / 07.08.2020 / PubMed / Full text
Machine learning-based estimation of cognitive performance using regional brain MRI markers: the Northern Manhattan Study. / 01.08.2020 / PubMed / Full text
Effects of an APOE Promoter Polymorphism on Fronto-Parietal Functional Connectivity During Nondemented Aging. / 2020 / PubMed / Full text
The relationship of parental longevity with the aging brain-results from UK Biobank. / 10.2020 / PubMed / Full text
Alzheimer's Patient Microglia Exhibit Enhanced Aging and Unique Transcriptional Activation. / 30.06.2020 / PubMed / Full text
Relationships Between Plasma Lipids Species, Gender, Risk Factors, and Alzheimer's Disease. / 2020 / PubMed / Full text
Effects of sex, age, and apolipoprotein E genotype on hippocampal parenchymal fraction in cognitively normal older adults. / 30.07.2020 / PubMed / Full text
Cognitive Health of Nonagenarians in Southern Italy: A Descriptive Analysis from a Cross-Sectional, Home-Based Pilot Study of Exceptional Longevity (Cilento Initiative on Aging Outcomes Or CIAO). / 05.05.2020 / PubMed / Full text
Apolipoprotein E and Health in Older Men: The Concord Health and Ageing in Men Project. / 25.09.2020 / PubMed / Full text
CSF amyloid is a consistent predictor of white matter hyperintensities across the disease course from aging to Alzheimer's disease. / 07.2020 / PubMed / Full text
Association of Cardiovascular Risk Factors with Cerebral Perfusion in Whites and African Americans. / 2020 / PubMed / Full text
Alzheimer's Risk Factors Age, APOE Genotype, and Sex Drive Distinct Molecular Pathways. / 03.06.2020 / PubMed / Full text
Less agreeable, better preserved? A PET amyloid and MRI study in a community-based cohort. / 05.2020 / PubMed / Full text
Physical Activity as Moderator of the Association Between APOE and Cognitive Decline in Older Adults: Results from Three Longitudinal Cohort Studies. / 25.09.2020 / PubMed / Full text
Longitudinal Maintenance of Cognitive Health in Centenarians in the 100-plus Study. / 05.02.2020 / PubMed / Full text
Interaction of APOE, cerebral blood flow, and cortical thickness in the entorhinal cortex predicts memory decline. / 04.2020 / PubMed / Full text
Determinants of mesial temporal lobe volume loss in older individuals with preserved cognition: a longitudinal PET amyloid study. / 03.2020 / PubMed / Full text
Long-term exposure to ambient air pollution, APOE-ε4 status, and cognitive decline in a cohort of older adults in northern Manhattan. / 03.2020 / PubMed / Full text
Evidence in support of chromosomal sex influencing plasma based metabolome vs APOE genotype influencing brain metabolome profile in humanized APOE male and female mice. / 2020 / PubMed / Full text
APOE region molecular signatures of Alzheimer's disease across races/ethnicities. / 03.2020 / PubMed / Full text
Varying Effects of APOE Alleles on Extreme Longevity in European Ethnicities. / 13.11.2019 / PubMed / Full text
Prospective Evaluation of Cognitive Health and Related Factors in Elderly at Risk for Developing Alzheimer's Dementia: A Longitudinal Cohort Study. / 2019 / PubMed / Full text
Association of Cardiovascular and Alzheimer's Disease Risk Factors with Intracranial Arterial Blood Flow in Whites and African Americans. / 2019 / PubMed / Full text
Is Ongoing Anticholinergic Burden Associated With Greater Cognitive Decline and Dementia Severity in Mild to Moderate Alzheimer's Disease? / 17.04.2020 / PubMed / Full text
Multicenter Alzheimer's and Parkinson's disease immune biomarker verification study. / 02.2020 / PubMed / Full text
Prospective Memory: Age related change is influenced by APOE genotype. / 09.2020 / PubMed / Full text
Education Moderates the Relation Between APOE ɛ4 and Memory in Nondemented Non-Hispanic Black Older Adults. / 2019 / PubMed / Full text
Apolipoprotein E ε4 allele effects on longitudinal cognitive trajectories are sex and age dependent. / 12.2019 / PubMed / Full text
Interactive effect of age and APOE-ε4 allele load on white matter myelin content in cognitively normal middle-aged subjects. / 2019 / PubMed / Full text
APOE modifies the interaction of entorhinal cerebral blood flow and cortical thickness on memory function in cognitively normal older adults. / 15.11.2019 / PubMed / Full text
When time's arrow doesn't bend: APOE-ε4 influences episodic memory before old age. / 10.2019 / PubMed / Full text
Cognitive-Motor Integration Performance Is Affected by Sex, APOE Status, and Family History of Dementia. / 2019 / PubMed / Full text
Associations among amyloid status, age, and longitudinal regional brain atrophy in cognitively unimpaired older adults. / 10.2019 / PubMed / Full text
Cognitive function and neuropathological outcomes: a forward-looking approach. / 12.2019 / PubMed / Full text
APOE gene-dependent BOLD responses to a breath-hold across the adult lifespan. / 2019 / PubMed / Full text
Medial temporal lobe atrophy and posterior atrophy scales normative values. / 2019 / PubMed / Full text
Apolipoprotein E gene polymorphism, posttraumatic stress disorder, and cognitive function in older U.S. veterans: Results from the National Health and Resilience in Veterans Study. / 09.2019 / PubMed / Full text
Genetic background, epigenetic factors and dietary interventions which influence human longevity. / 10.2019 / PubMed / Full text
Adipose-Derived Stem/Stromal Cells Recapitulate Aging Biomarkers and Show Reduced Stem Cell Plasticity Affecting Their Adipogenic Differentiation Capacity. / 08.2019 / PubMed / Full text
Late life insulin resistance and Alzheimer's disease and dementia: The Kuakini Honolulu heart program. / 15.08.2019 / PubMed / Full text
Latent Classes of Cognitive Functioning Among Depressed Older Adults Without Dementia. / 09.2019 / PubMed / Full text
Lifespan Intellectual Factors, Genetic Susceptibility, and Cognitive Phenotypes in Aging: Implications for Interventions. / 2019 / PubMed / Full text
Cyclic O exposure synergizes with aging leading to memory impairment in male APOE ε3, but not APOE ε4, targeted replacement mice. / 09.2019 / PubMed / Full text
Alzheimer's disease and symbiotic microbiota: an evolutionary medicine perspective. / 08.2019 / PubMed / Full text
The role of APOE in transgenic mouse models of AD. / 10.08.2019 / PubMed / Full text
Sex differences in mixed neuropathologies in community-dwelling older adults. / 15.09.2019 / PubMed / Full text
Women Outperform Men in Verbal Episodic Memory Even in Oldest-Old Age: 13-Year Longitudinal Results of the AgeCoDe/AgeQualiDe Study. / 2019 / PubMed / Full text
APOE Effect on Amyloid-β PET Spatial Distribution, Deposition Rate, and Cut-Points. / 2019 / PubMed / Full text
Sex differences in the association of APOE ε4 genotype with longitudinal hippocampal atrophy in cognitively normal older people. / 11.2019 / PubMed / Full text
Predictors and Implications of Accelerated Cognitive Aging. / 2018 / PubMed / Full text
Association of Cortical β-Amyloid Protein in the Absence of Insoluble Deposits With Alzheimer Disease. / 01.07.2019 / PubMed / Full text
Sex differences in the association between amyloid and longitudinal brain volume change in cognitively normal older adults. / 2019 / PubMed / Full text
Region-specific association between basal blood insulin and cerebral glucose metabolism in older adults. / 2019 / PubMed / Full text
Association between APOE e4 and white matter hyperintensity volume, but not total brain volume or white matter integrity. / 10.2020 / PubMed / Full text
Cortical β-amyloid burden, neuropsychiatric symptoms, and cognitive status: the Mayo Clinic Study of Aging. / 28.03.2019 / PubMed / Full text
Nuances in Alzheimer's Genetic Risk Reveal Differential Predictions of Non-demented Memory Aging Trajectories: Selective Patterns by APOE Genotype and Sex. / 2019 / PubMed / Full text
A prospective study of focal brain atrophy, mobility and fitness. / 07.2019 / PubMed / Full text
10-year follow-up of the Super-Seniors Study: compression of morbidity and genetic factors. / 28.02.2019 / PubMed / Full text
Increases in a Pro-inflammatory Chemokine, MCP-1, Are Related to Decreases in Memory Over Time. / 2019 / PubMed / Full text
Taste receptors, innate immunity and longevity: the case of TAS2R16 gene. / 2019 / PubMed / Full text
The Role of APOE4 in Disrupting the Homeostatic Functions of Astrocytes and Microglia in Aging and Alzheimer's Disease. / 2019 / PubMed / Full text
The influence of tau, amyloid, alpha-synuclein, TDP-43, and vascular pathology in clinically normal elderly individuals. / 05.2019 / PubMed / Full text
Opposing Roles of apolipoprotein E in aging and neurodegeneration. / 02.2019 / PubMed / Full text
Effects of APOE on cognitive aging in community-dwelling older adults. / 03.2019 / PubMed / Full text
A candidate gene study of risk for dementia in older, postmenopausal women: Results from the Women's Health Initiative Memory Study. / 05.2019 / PubMed / Full text
Apolipoprotein E4 Mediates the Association Between Midlife Dyslipidemia and Cerebral Amyloid in Aging Women. / 2019 / PubMed / Full text
Apolipoprotein E gene in physiological and pathological aging. / 03.2019 / PubMed / Full text
Spatial patterns of white matter hyperintensities associated with Alzheimer's disease risk factors in a cognitively healthy middle-aged cohort. / 24.01.2019 / PubMed / Full text
The Role of MRI Biomarkers and Their Interactions with Cognitive Status and APOE ε4 in Nondemented Elderly Subjects. / 2018 / PubMed / Full text
Longitudinal tau accumulation and atrophy in aging and alzheimer disease. / 02.2019 / PubMed / Full text
Apolipoprotein E Genotypes, Age, Race, and Cognitive Decline in a Population Sample. / 04.2019 / PubMed / Full text
Predictors of neurodegeneration differ between cognitively normal and subsequently impaired older adults. / 03.2019 / PubMed / Full text
Vascular burden and APOE ε4 are associated with white matter microstructural decline in cognitively normal older adults. / 03.2019 / PubMed / Full text
Responses to executive demand in young adulthood differ by APOE genotype. / 15.03.2019 / PubMed / Full text
Mild Cognitive Impairment that Does Not Progress to Dementia: A Population-Based Study. / 02.2019 / PubMed / Full text
Neuropathologic, genetic, and longitudinal cognitive profiles in primary age-related tauopathy (PART) and Alzheimer's disease. / 01.2019 / PubMed / Full text
Independent associations of TOMM40 and APOE variants with body mass index. / 02.2019 / PubMed / Full text
Apolipoprotein E genotype moderates the association between dietary polyunsaturated fat and brain function: an exploration of cerebral glutamate and cognitive performance. / 09.2020 / PubMed / Full text
Circulating Vascular Growth Factors and Magnetic Resonance Imaging Markers of Small Vessel Disease and Atrophy in Middle-Aged Adults. / 09.2018 / PubMed / Full text
The 100-plus Study of cognitively healthy centenarians: rationale, design and cohort description. / 12.2018 / PubMed / Full text
Report: NIA workshop on translating genetic variants associated with longevity into drug targets. / 12.2018 / PubMed / Full text
Dendritic spine remodeling accompanies Alzheimer's disease pathology and genetic susceptibility in cognitively normal aging. / 01.2019 / PubMed / Full text
The ApoE ε4 Isoform: Can the Risk of Diseases be Reduced by Environmental Factors? / 01.01.2019 / PubMed / Full text
Genetics of Human Longevity From Incomplete Data: New Findings From the Long Life Family Study. / 08.10.2018 / PubMed / Full text
Amygdala subnuclei and healthy cognitive aging. / 01.2019 / PubMed / Full text
APOE ɛ4, rs405509, and rs440446 promoter and intron-1 polymorphisms and dementia risk in a cohort of elderly Finns-Helsinki Birth Cohort Study. / 01.2019 / PubMed / Full text
The Cross-sectional and Longitudinal Associations Between IL-6, IL-10, and TNFα and Cognitive Outcomes in the Mayo Clinic Study of Aging. / 12.07.2019 / PubMed / Full text
The effect of midlife cardiovascular risk factors on white matter hyperintensity volume and cognition two decades later in normal ageing women. / 02.2020 / PubMed / Full text
Sex and age interact to determine clinicopathologic differences in Alzheimer's disease. / 12.2018 / PubMed / Full text
Relationship Between Amyloid-β Positivity and Progression to Mild Cognitive Impairment or Dementia over 8 Years in Cognitively Normal Older Adults. / 2018 / PubMed / Full text
Lifetime Risk Factors for Functional and Cognitive Outcomes in Patients with Alzheimer's Disease. / 2018 / PubMed / Full text
Microglial translational profiling reveals a convergent APOE pathway from aging, amyloid, and tau. / 03.09.2018 / PubMed / Full text
Childhood socioeconomic status and genetic risk for poorer cognition in later life. / 09.2018 / PubMed / Full text
Diffuse Amyloid-β Plaques, Neurofibrillary Tangles, and the Impact of APOE in Elderly Persons' Brains Lacking Neuritic Amyloid Plaques. / 2018 / PubMed / Full text
Polygenic analysis of inflammatory disease variants and effects on microglia in the aging brain. / 24.07.2018 / PubMed / Full text
Dual-Task Gait and Alzheimer's Disease Genetic Risk in Cognitively Normal Adults: A Pilot Study. / 2018 / PubMed / Full text
Higher Aortic Stiffness Is Related to Lower Cerebral Blood Flow and Preserved Cerebrovascular Reactivity in Older Adults. / 30.10.2018 / PubMed / Full text
Physical activity effects on the individual alpha peak frequency of older adults with and without genetic risk factors for Alzheimer's Disease: A MEG study. / 09.2018 / PubMed / Full text
Racial and Ethnic Disparities in Dementia Risk Among Individuals With Low Education. / 09.2018 / PubMed / Full text
Increased CAIDE dementia risk, cognition, CSF biomarkers, and vascular burden in healthy adults. / 17.07.2018 / PubMed / Full text
Differential 5-year brain atrophy rates in cognitively declining and stable APOE-ε4 elders. / 09.2018 / PubMed / Full text
Review and meta-analysis of genetic polymorphisms associated with exceptional human longevity. / 10.2018 / PubMed / Full text
Using event-related fMRI to examine sustained attention processes and effects of APOE ε4 in young adults. / 2018 / PubMed / Full text
Genetic Risk for Age-Related Cognitive Impairment Does Not Predict Cognitive Performance in Middle Age. / 2018 / PubMed / Full text
White matter microstructure is altered in cognitively normal middle-aged APOE-ε4 homozygotes. / 24.05.2018 / PubMed / Full text
Effects of lifetime cumulative ginseng intake on cognitive function in late life. / 24.05.2018 / PubMed / Full text
Apolipoprotein E region molecular signatures of Alzheimer's disease. / 08.2018 / PubMed / Full text
Does incipient dementia explain normal cognitive decline determinants? Lothian birth cohort 1921. / 06.2018 / PubMed / Full text
An 18-mo randomized, double-blind, placebo-controlled trial of DHA-rich fish oil to prevent age-related cognitive decline in cognitively normal older adults. / 01.05.2018 / PubMed / Full text
The Role of Apolipoprotein E and Ethanol Exposure in Age-Related Changes in Choline Acetyltransferase and Brain-Derived Neurotrophic Factor Expression in the Mouse Hippocampus. / 05.2018 / PubMed / Full text
APOE genotype modifies the association between central arterial stiffening and cognition in older adults. / 07.2018 / PubMed / Full text
Age-Dependent Changes to Sphingolipid Balance in the Human Hippocampus are Gender-Specific and May Sensitize to Neurodegeneration. / 2018 / PubMed / Full text
Brain Aging and APOE ε4 Interact to Reveal Potential Neuronal Compensation in Healthy Older Adults. / 2018 / PubMed / Full text
Leisure-Time Physical Activity and the Risk of Incident Dementia: The Mayo Clinic Study of Aging. / 2018 / PubMed / Full text
Effects of APOE-ε4 allele load on brain morphology in a cohort of middle-aged healthy individuals with enriched genetic risk for Alzheimer's disease. / 07.2018 / PubMed / Full text
APOE influences working memory in non-demented elderly through an interaction with SPON1 rs2618516. / 07.2018 / PubMed / Full text
Altered effective connectivity anchored in the posterior cingulate cortex and the medial prefrontal cortex in cognitively intact elderly APOE ε4 carriers: a preliminary study. / 02.2019 / PubMed / Full text
Plasma Cortisol, Brain Amyloid-β, and Cognitive Decline in Preclinical Alzheimer's Disease: A 6-Year Prospective Cohort Study. / 01.2017 / PubMed / Full text
Apolipoprotein E genotypes and longevity across dementia disorders. / 07.2018 / PubMed / Full text
Differential Effect of APOE ɛ4 Status and Elevated Pulse Pressure on Functional Decline in Cognitively Normal Older Adults. / 2018 / PubMed / Full text
Functional segregation loss over time is moderated by APOE genotype in healthy elderly. / 07.2018 / PubMed / Full text
Dementia Prevalence in Greece: The Hellenic Longitudinal Investigation of Aging and Diet (HELIAD). / 07-09.2018 / PubMed / Full text
Atypical Localization and Dissociation between Glucose Uptake and Amyloid Deposition in Cognitively Normal APOE*E4 Homozygotic Elders Compared with Patients with Late-Onset Alzheimer's Disease. / 01-02.2018 / PubMed / Full text
Association between subjective memory assessment and associative memory performance: Role of ad risk factors. / 02.2018 / PubMed / Full text
Reduced Gray Matter Volume of the Thalamus and Hippocampal Region in Elderly Healthy Adults with no Impact of APOE ɛ4: A Longitudinal Voxel-Based Morphometry Study. / 2018 / PubMed / Full text
Apolipoprotein E genotype does not moderate the associations of depressive symptoms, neuroticism and allostatic load with cognitive ability and cognitive aging in the Lothian Birth Cohort 1936. / 2018 / PubMed / Full text
A Network of Genetic Effects on Non-Demented Cognitive Aging: Alzheimer's Genetic Risk (CLU + CR1 + PICALM) Intensifies Cognitive Aging Genetic Risk (COMT + BDNF) Selectively for APOEɛ4 Carriers. / 2018 / PubMed / Full text
Recent studies on cellular and molecular mechanisms in Alzheimer's disease: focus on epigenetic factors and histone deacetylase. / 28.03.2018 / PubMed / Full text
Genetic Variation in FOXO3 is Associated with Self-Rated Health in a Population-Based Sample of Older Individuals. / 08.10.2018 / PubMed / Full text
APOE ε4 Genotype and Cognitive Reserve Effects on the Cognitive Functioning of Healthy Elders. / 2017 / PubMed / Full text
Distinct neural correlates of episodic memory among apolipoprotein E alleles in cognitively normal elderly. / 02.2019 / PubMed / Full text
Age-Dependent Effects of apoE Reduction Using Antisense Oligonucleotides in a Model of β-amyloidosis. / 06.12.2017 / PubMed / Full text
Features associated with cognitive impairment and dementia in a community-based sample of illiterate elderly aged 75+ years: the Pietà study. / 04-06.2014 / PubMed / Full text
Epistasis, physical capacity-related genes and exceptional longevity: FNDC5 gene interactions with candidate genes FOXOA3 and APOE. / 14.11.2017 / PubMed / Full text
Neuronal hyperactivity due to loss of inhibitory tone in APOE4 mice lacking Alzheimer's disease-like pathology. / 13.11.2017 / PubMed / Full text
Green space and cognitive ageing: A retrospective life course analysis in the Lothian Birth Cohort 1936. / 01.2018 / PubMed / Full text
Preclinical effects of APOE ε4 on cerebrospinal fluid Aβ42 concentrations. / 23.10.2017 / PubMed / Full text
Genome-wide meta-analysis associates HLA-DQA1/DRB1 and LPA and lifestyle factors with human longevity. / 13.10.2017 / PubMed / Full text
Phenome and genome based studies into human ageing and longevity: An overview. / 09.2018 / PubMed / Full text
A Tale of Two Genes: Microglial Apoe and Trem2. / 19.09.2017 / PubMed / Full text
The Association of Apolipoprotein E Gene Polymorphism With Cognitive Performance in Nondemented Polish Adults Aged 55 to 75. / 09.2018 / PubMed / Full text
Cognitive Aging in Black and White Americans: Cognition, Cognitive Decline, and Incidence of Alzheimer Disease Dementia. / 01.2018 / PubMed / Full text
Alzheimer's Disease Biomarkers Interactively Influence Physical Activity, Mobility, and Cognition Associations in a Non-Demented Aging Population. / 2017 / PubMed / Full text
Genetic variants specific to aging-related verbal memory: Insights from GWASs in a population-based cohort. / 2017 / PubMed / Full text

MSC

Rejuvenation of Senescent Endothelial Progenitor Cells by Extracellular Vesicles Derived From Mesenchymal Stromal Cells. / 11.2020 / PubMed / Full text
Extracellular vesicles derived from bone marrow mesenchymal stem cells enhance myelin maintenance after cortical injury in aged rhesus monkeys. / 29.11.2020 / PubMed / Full text
TPP1 Enhances the Therapeutic Effects of Transplanted Aged Mesenchymal Stem Cells in Infarcted Hearts via the MRE11/AKT Pathway. / 2020 / PubMed / Full text
Aging-Affected MSC Functions and Severity of Periodontal Tissue Destruction in a Ligature-Induced Mouse Periodontitis Model. / 30.10.2020 / PubMed / Full text
Human placenta-derived mesenchymal stem cells stimulate ovarian function via miR-145 and bone morphogenetic protein signaling in aged rats. / 05.11.2020 / PubMed / Full text
Mesenchymal Stromal Cells as Critical Contributors to Tissue Regeneration. / 2020 / PubMed / Full text
The biology of human hair greying. / 23.09.2020 / PubMed / Full text
[i]Tsc1[/i] Regulates the Proliferation Capacity of Bone-Marrow Derived Mesenchymal Stem Cells. / 10.09.2020 / PubMed / Full text
The role of mitochondrial dysfunction in mesenchymal stem cell senescence. / 12.2020 / PubMed / Full text
Metabolic syndrome increases senescence-associated micro-RNAs in extracellular vesicles derived from swine and human mesenchymal stem/stromal cells. / 12.08.2020 / PubMed / Full text
Functional heterogeneity of mesenchymal stem cells from natural niches to culture conditions: implications for further clinical uses. / 22.07.2020 / PubMed / Full text
Functional crosstalk between mTORC1/p70S6K pathway and heterochromatin organization in stress-induced senescence of MSCs. / 13.07.2020 / PubMed / Full text
Increased cellular senescence in the murine and human stenotic kidney: Effect of mesenchymal stem cells. / 02.2021 / PubMed / Full text
Intrinsic Type 1 Interferon (IFN1) Profile of Uncultured Human Bone Marrow CD45 CD271 Multipotential Stromal Cells (BM-MSCs): The Impact of Donor Age, Culture Expansion and IFNα and IFNβ Stimulation. / 15.07.2020 / PubMed / Full text
Facial rejuvenation using stem cell conditioned media combined with skin needling: A split-face comparative study. / 09.2020 / PubMed / Full text
Mesenchymal Stem Cell Senescence and Rejuvenation: Current Status and Challenges. / 2020 / PubMed / Full text
The changing epigenetic landscape of Mesenchymal Stem/Stromal Cells during aging. / 08.2020 / PubMed / Full text
Dual Role of Autophagy in Regulation of Mesenchymal Stem Cell Senescence. / 2020 / PubMed / Full text
Molecular Aspects of Adipose-Derived Stromal Cell Senescence in a Long-Term Culture: A Potential Role of Inflammatory Pathways. / 01-12.2020 / PubMed / Full text
Human Obesity Induces Dysfunction and Early Senescence in Adipose Tissue-Derived Mesenchymal Stromal/Stem Cells. / 2020 / PubMed / Full text
miR-155-5p inhibition rejuvenates aged mesenchymal stem cells and enhances cardioprotection following infarction. / 04.2020 / PubMed / Full text
Mesenchymal Stem Cell Derived Extracellular Vesicles in Aging. / 2020 / PubMed / Full text
Molecular Mechanisms Contributing to Mesenchymal Stromal Cell Aging. / 21.02.2020 / PubMed / Full text
Inhibition of DNA Methyltransferase by RG108 Promotes Pluripotency-Related Character of Porcine Bone Marrow Mesenchymal Stem Cells. / 04.2020 / PubMed / Full text
Extracellular Vesicles of Stem Cells to Prevent BRONJ. / 05.2020 / PubMed / Full text
Ginsenoside Rg1 as an Effective Regulator of Mesenchymal Stem Cells. / 2019 / PubMed / Full text
The Importance of Stem Cell Senescence in Regenerative Medicine. / 2020 / PubMed / Full text
Control of mesenchymal stem cell biology by histone modifications. / 2020 / PubMed / Full text
Impact of mesenchymal stem cell senescence on inflammaging. / 02.2020 / PubMed / Full text
Late Rescue Therapy with Cord-Derived Mesenchymal Stromal Cells for Established Lung Injury in Experimental Bronchopulmonary Dysplasia. / 15.03.2020 / PubMed / Full text
Low-Level Radiofrequency Exposure Does Not Induce Changes in MSC Biology: An in vitro Study for the Prevention of NIR-Related Damage. / 2019 / PubMed / Full text
Macrophage migration inhibitory factor rejuvenates aged human mesenchymal stem cells and improves myocardial repair. / 27.12.2019 / PubMed / Full text
Influence of olive oil and its components on mesenchymal stem cell biology. / 26.12.2019 / PubMed / Full text
Epigenetic Regulation of Mesenchymal Stem Cell Homeostasis. / 02.2020 / PubMed / Full text
Mesenchymal Stem Cells: Allogeneic MSC May Be Immunosuppressive but Autologous MSC Are Dysfunctional in Lupus Patients. / 2019 / PubMed / Full text
Effects of high glucose conditions on the expansion and differentiation capabilities of mesenchymal stromal cells derived from rat endosteal niche. / 21.11.2019 / PubMed / Full text
Autophagy inhibits the mesenchymal stem cell aging induced by D-galactose through ROS/JNK/p38 signalling. / 03.2020 / PubMed / Full text
Enhancing survival, engraftment, and osteogenic potential of mesenchymal stem cells. / 26.10.2019 / PubMed / Full text
Mesenchymal stem cell senescence alleviates their intrinsic and seno-suppressive paracrine properties contributing to osteoarthritis development. / 22.10.2019 / PubMed / Full text
Embryonic stem cell-derived extracellular vesicles enhance the therapeutic effect of mesenchymal stem cells. / 2019 / PubMed / Full text
Survival of aging CD264 and CD264 populations of human bone marrow mesenchymal stem cells is independent of colony-forming efficiency. / 01.2020 / PubMed / Full text
Differential effects of extracellular vesicles from aging and young mesenchymal stem cells in acute lung injury. / 29.09.2019 / PubMed / Full text
Connexin43 is Dispensable for Early Stage Human Mesenchymal Stem Cell Adipogenic Differentiation But is Protective against Cell Senescence. / 11.09.2019 / PubMed / Full text
Maintained Properties of Aged Dental Pulp Stem Cells for Superior Periodontal Tissue Regeneration. / 08.2019 / PubMed / Full text
Mesenchymal Stem Cells in Homeostasis and Systemic Diseases: Hypothesis, Evidences, and Therapeutic Opportunities. / 31.07.2019 / PubMed / Full text
Tunneling nanotubes mediate the expression of senescence markers in mesenchymal stem/stromal cell spheroids. / 01.2020 / PubMed / Full text
Adipose-Derived Stem/Stromal Cells Recapitulate Aging Biomarkers and Show Reduced Stem Cell Plasticity Affecting Their Adipogenic Differentiation Capacity. / 08.2019 / PubMed / Full text
Effect of aging on behaviour of mesenchymal stem cells. / 26.06.2019 / PubMed / Full text
Human colorectal cancer derived-MSCs promote tumor cells escape from senescence via P53/P21 pathway. / 04.2020 / PubMed / Full text
Rapid Detection of Senescent Mesenchymal Stromal Cells by a Fluorescent Probe. / 10.2019 / PubMed / Full text
Nicotinamide phosphoribosyltransferase postpones rat bone marrow mesenchymal stem cell senescence by mediating NAD -Sirt1 signaling. / 07.06.2019 / PubMed / Full text
Identification of senescent cells in multipotent mesenchymal stromal cell cultures: Current methods and future directions. / 08.2019 / PubMed / Full text
Genetic Stability of Mesenchymal Stromal Cells for Regenerative Medicine Applications: A Fundamental Biosafety Aspect. / 15.05.2019 / PubMed / Full text
Quantifying Senescence-Associated Phenotypes in Primary Multipotent Mesenchymal Stromal Cell Cultures. / 2019 / PubMed / Full text
Nicotinamide mononucleotide promotes osteogenesis and reduces adipogenesis by regulating mesenchymal stromal cells via the SIRT1 pathway in aged bone marrow. / 18.04.2019 / PubMed / Full text
Low-Dose Pesticide Mixture Induces Accelerated Mesenchymal Stem Cell Aging In Vitro. / 08.2019 / PubMed / Full text
Alterations in genetic and protein content of swine adipose tissue-derived mesenchymal stem cells in the metabolic syndrome. / 05.2019 / PubMed / Full text
Circulating factors present in the sera of naturally skinny people may influence cell commitment and adipocyte differentiation of mesenchymal stromal cells. / 26.03.2019 / PubMed / Full text
Mesenchymal stem cell therapy improves spatial memory and hippocampal structure in aging rats. / 18.11.2019 / PubMed / Full text
Immunophenotypic characterization, multi-lineage differentiation and aging of zebrafish heart and liver tissue-derived mesenchymal stem cells as a novel approach in stem cell-based therapy. / 04.2019 / PubMed / Full text
Accumulating Transcriptome Drift Precedes Cell Aging in Human Umbilical Cord-Derived Mesenchymal Stromal Cells Serially Cultured to Replicative Senescence. / 09.2019 / PubMed / Full text
Cell Therapy for Knee Osteoarthritis: Mesenchymal Stromal Cells. / 2019 / PubMed / Full text
Human iPSC-derived MSCs (iMSCs) from aged individuals acquire a rejuvenation signature. / 18.03.2019 / PubMed / Full text
Impact of HOXB7 overexpression on human adipose-derived mesenchymal progenitors. / 19.03.2019 / PubMed / Full text
Bmi1 Overexpression in Mesenchymal Stem Cells Exerts Antiaging and Antiosteoporosis Effects by Inactivating p16/p19 Signaling and Inhibiting Oxidative Stress. / 09.2019 / PubMed / Full text
An early-senescence state in aged mesenchymal stromal cells contributes to hematopoietic stem and progenitor cell clonogenic impairment through the activation of a pro-inflammatory program. / 06.2019 / PubMed / Full text
Identification of key genes and transcription factors in aging mesenchymal stem cells by DNA microarray data. / 15.04.2019 / PubMed / Full text
Overexpression of ERBB4 rejuvenates aged mesenchymal stem cells and enhances angiogenesis via PI3K/AKT and MAPK/ERK pathways. / 03.2019 / PubMed / Full text
MiR-1292 Targets FZD4 to Regulate Senescence and Osteogenic Differentiation of Stem Cells in TE/SJ/Mesenchymal Tissue System via the Wnt/β-catenin Pathway. / 12.2018 / PubMed / Full text
Aging of mesenchymal stem cells: Implication in regenerative medicine. / 12.2018 / PubMed / Full text
Effect of intra-ovarian injection of mesenchymal stem cells in aged mares. / 03.2019 / PubMed / Full text
Adipogenic and Osteogenic Differentiation of In Vitro Aged Human Mesenchymal Stem Cells. / 2019 / PubMed / Full text
Effects of senescent secretory phenotype acquisition on human retinal pigment epithelial stem cells. / 16.11.2018 / PubMed / Full text
Comparison of Oxidative Stress Effects on Senescence Patterning of Human Adult and Perinatal Tissue-Derived Stem Cells in Short and Long-term Cultures. / 2018 / PubMed / Full text
Evaluation of human mesenchymal stem cell senescence, differentiation and secretion behavior cultured on polycarbonate cell culture inserts. / 2018 / PubMed / Full text
Characterization of embryonic stem cell-differentiated fibroblasts as mesenchymal stem cells with robust expansion capacity and attenuated innate immunity. / 25.10.2018 / PubMed / Full text
Can mesenchymal stem cell lysate reverse aging? / 24.10.2018 / PubMed / Full text
The GDF11-FTO-PPARγ axis controls the shift of osteoporotic MSC fate to adipocyte and inhibits bone formation during osteoporosis. / 12.2018 / PubMed / Full text
Senescence of bone marrow-derived mesenchymal stem cells from patients with idiopathic pulmonary fibrosis. / 26.09.2018 / PubMed / Full text
Micro-RNAS Regulate Metabolic Syndrome-induced Senescence in Porcine Adipose Tissue-derived Mesenchymal Stem Cells through the P16/MAPK Pathway. / 10.2018 / PubMed / Full text
Regenerative potential of human nucleus pulposus resident stem/progenitor cells declines with ageing and intervertebral disc degeneration. / 10.2018 / PubMed / Full text
Bone marrow mesenchymal stem cells: Aging and tissue engineering applications to enhance bone healing. / 05.2019 / PubMed / Full text
Hybrid complexes of high and low molecular weight hyaluronan delay in vitro replicative senescence of mesenchymal stromal cells: a pilot study for future therapeutic application. / 12.07.2018 / PubMed / Full text
Mesenchymal Stromal Cell Characteristics and Regenerative Potential in Cardiovascular Disease: Implications for Cellular Therapy. / 05.2018 / PubMed / Full text
Elevated levels of the small GTPase Cdc42 induces senescence in male rat mesenchymal stem cells. / 07.2018 / PubMed / Full text
Ascorbic acid inhibits senescence in mesenchymal stem cells through ROS and AKT/mTOR signaling. / 10.2018 / PubMed / Full text
Co-Administration of Melatonin Effectively Enhances the Therapeutic Effects of Pioglitazone on Mesenchymal Stem Cells Undergoing Indoxyl Sulfate-Induced Senescence through Modulation of Cellular Prion Protein Expression. / 04.05.2018 / PubMed / Full text
Changes in phenotype and differentiation potential of human mesenchymal stem cells aging in vitro. / 11.05.2018 / PubMed / Full text
Improvement of Cell Cycle Lifespan and Genetic Damage Susceptibility of Human Mesenchymal Stem Cells by Hypoxic Priming. / 30.05.2018 / PubMed / Full text
Aging impairs beige adipocyte differentiation of mesenchymal stem cells via the reduced expression of Sirtuin 1. / 07.06.2018 / PubMed / Full text
GH prevents adipogenic differentiation of mesenchymal stromal stem cells derived from human trabecular bone via canonical Wnt signaling. / 07.2018 / PubMed / Full text
Fucoidan Rescues p-Cresol-Induced Cellular Senescence in Mesenchymal Stem Cells via FAK-Akt-TWIST Axis. / 06.04.2018 / PubMed / Full text
Dysfunction of Mesenchymal Stem Cells Isolated from Metabolic Syndrome and Type 2 Diabetic Patients as Result of Oxidative Stress and Autophagy may Limit Their Potential Therapeutic Use. / 06.2018 / PubMed / Full text
Isolating Pediatric Mesenchymal Stem Cells with Enhanced Expansion and Differentiation Capabilities. / 06.2018 / PubMed / Full text
Mesenchymal stem cell transplantation in systemic lupus erythematous, a mesenchymal stem cell disorder. / 06.2018 / PubMed / Full text
A brain-age model for preterm infants based on functional connectivity. / 26.04.2018 / PubMed / Full text
Diabetic serum from older women increases adipogenic differentiation in mesenchymal stem cells. / 08.2018 / PubMed / Full text
Hypoxia Upregulates Mitotic Cyclins Which Contribute to the Multipotency of Human Mesenchymal Stem Cells by Expanding Proliferation Lifespan. / 31.03.2018 / PubMed / Full text
Automated image analysis detects aging in clinical-grade mesenchymal stromal cell cultures. / 10.01.2018 / PubMed / Full text
Mesenchymal Stem Cells Secretory Responses: Senescence Messaging Secretome and Immunomodulation Perspective. / 2017 / PubMed / Full text
Glutathione Peroxidase 3 Delivered by hiPSC-MSCs Ameliorated Hepatic IR Injury via Inhibition of Hepatic Senescence. / 2018 / PubMed / Full text
Graft-Versus-Host Disease Amelioration by Human Bone Marrow Mesenchymal Stromal/Stem Cell-Derived Extracellular Vesicles Is Associated with Peripheral Preservation of Naive T Cell Populations. / 03.2018 / PubMed / Full text
Orthogonal potency analysis of mesenchymal stromal cell function during ex vivo expansion. / 01.01.2018 / PubMed / Full text
Impact of Age on Human Adipose Stem Cells for Bone Tissue Engineering. / 09.2017 / PubMed / Full text
Age-related Changes in Bone Marrow Mesenchymal Stromal Cells: A Potential Impact on Osteoporosis and Osteoarthritis Development. / 09.2017 / PubMed / Full text
Restoring the quantity and quality of elderly human mesenchymal stem cells for autologous cell-based therapies. / 27.10.2017 / PubMed / Full text
Decoy TRAIL receptor CD264: a cell surface marker of cellular aging for human bone marrow-derived mesenchymal stem cells. / 29.09.2017 / PubMed / Full text
Allogeneic Mesenchymal Stem Cells Ameliorate Aging Frailty: A Phase II Randomized, Double-Blind, Placebo-Controlled Clinical Trial. / 12.10.2017 / PubMed / Full text
Long noncoding RNA‑p21 modulates cellular senescence via the Wnt/β‑catenin signaling pathway in mesenchymal stem cells. / 11.2017 / PubMed / Full text
Reduced neuroprotective potential of the mesenchymal stromal cell secretome with ex vivo expansion, age and progressive multiple sclerosis. / 01.2018 / PubMed / Full text
Lactoferrin Protects Human Mesenchymal Stem Cells from Oxidative Stress-Induced Senescence and Apoptosis. / 28.10.2017 / PubMed / Full text
Methylome Analysis of Human Bone Marrow MSCs Reveals Extensive Age- and Culture-Induced Changes at Distal Regulatory Elements. / 12.09.2017 / PubMed / Full text
Effects of sulfur mustard on mesenchymal stem cells. / 01.09.2018 / PubMed / Full text
Concise Review: Musculoskeletal Stem Cells to Treat Age-Related Osteoporosis. / 10.2017 / PubMed / Full text
Microvesicles as Potential Biomarkers for the Identification of Senescence in Human Mesenchymal Stem Cells. / 2017 / PubMed / Full text
Activated Tissue-Resident Mesenchymal Stromal Cells Regulate Natural Killer Cell Immune and Tissue-Regenerative Function. / 12.09.2017 / PubMed / Full text
IFN-γ induces senescence-like characteristics in mouse bone marrow mesenchymal stem cells. / 03-04.2017 / PubMed / Full text

BDNF

Influence of [i]BDNF[/i] Genetic Polymorphisms in the Pathophysiology of Aging-related Diseases. / 12.2020 / PubMed / Full text
Moderators of the Impact of (Poly)Phenols Interventions on Psychomotor Functions and BDNF: Insights from Subgroup Analysis and Meta-Regression. / 19.09.2020 / PubMed / Full text
Astroglia-Derived BDNF and MSK-1 Mediate Experience- and Diet-Dependent Synaptic Plasticity. / 18.07.2020 / PubMed / Full text
BDNF reverses aging-related microglial activation. / 14.07.2020 / PubMed / Full text
High Supervised Resistance Training in Elderly Women: The Role of Supervision Ratio. / 2020 / PubMed / Full text
Metformin regulates astrocyte reactivity in Parkinson's disease and normal aging. / 15.09.2020 / PubMed / Full text
Aging-Induced Brain-Derived Neurotrophic Factor in Adipocyte Progenitors Contributes to Adipose Tissue Dysfunction. / 05.2020 / PubMed / Full text
The Role of BDNF on Aging-Modulation Markers. / 09.05.2020 / PubMed / Full text
Spermidine and spermine delay brain aging by inducing autophagy in SAMP8 mice. / 08.04.2020 / PubMed / Full text
Microglia senescence occurs in both substantia nigra and ventral tegmental area. / 11.2020 / PubMed / Full text
Towards an understanding of the physical activity-BDNF-cognition triumvirate: A review of associations and dosage. / 07.2020 / PubMed / Full text
Impact of BDNF and sex on maintaining intact memory function in early midlife. / 04.2020 / PubMed / Full text
Testosterone replacement causes dose-dependent improvements in spatial memory among aged male rats. / 03.2020 / PubMed / Full text
The effects of aerobic exercise intensity on memory in older adults. / 06.2020 / PubMed / Full text
Protective effects of vitamin D on neurophysiologic alterations in brain aging: role of brain-derived neurotrophic factor (BDNF). / 16.09.2019 / PubMed / Full text
Differential Effects of Physical Exercise, Cognitive Training, and Mindfulness Practice on Serum BDNF Levels in Healthy Older Adults: A Randomized Controlled Intervention Study. / 2019 / PubMed / Full text
Dietary Supplementation with Fish Oil or Conjugated Linoleic Acid Relieves Depression Markers in Mice by Modulation of the Nrf2 Pathway. / 11.2019 / PubMed / Full text
Neuroprotective Biomarkers and Cognitive Function in a Long-Term Prospective Population-based Study of Aging US Adults. / 01-03.2020 / PubMed / Full text
URB597 ameliorates the deleterious effects induced by binge alcohol consumption in adolescent rats. / 15.10.2019 / PubMed / Full text
Pro-neurocognitive and anti-sarcopenic benefits of one-year metformin therapy in ovariectomized aged mice. / 12.2019 / PubMed / Full text
Ellagic acid dose and time-dependently abrogates d-galactose-induced animal model of aging: Investigating the role of PPAR-γ. / 01.09.2019 / PubMed / Full text
Astrocyte Function Is Affected by Aging and Not Alzheimer's Disease: A Preliminary Investigation in Hippocampi of 3xTg-AD Mice. / 2019 / PubMed / Full text
Exenatide Reverts the High-Fat-Diet-Induced Impairment of BDNF Signaling and Inflammatory Response in an Animal Model of Alzheimer's Disease. / 2019 / PubMed / Full text
The Impact of Physical Exercise on Brain-Derived Neurotrophic Factor (BDNF) Level in Elderly Population. / 31.05.2019 / PubMed / Full text
Cardioprotective effects of microRNA-18a on acute myocardial infarction by promoting cardiomyocyte autophagy and suppressing cellular senescence via brain derived neurotrophic factor. / 2019 / PubMed / Full text
Exercise enhances the expression of brain-derived neurotrophic factor in the hippocampus accompanied by epigenetic alterations in senescence-accelerated mice prone 8. / 27.07.2019 / PubMed / Full text
Melatonin alleviates cognition impairment by antagonizing brain insulin resistance in aged rats fed a high-fat diet. / 09.2019 / PubMed / Full text
Gross Motor Skills Training Leads to Increased Brain-Derived Neurotrophic Factor Levels in Healthy Older Adults: A Pilot Study. / 2019 / PubMed / Full text
Dysregulation of the SNARE-binding protein Munc18-1 impairs BDNF secretion and synaptic neurotransmission: a novel interventional target to protect the aging brain. / 04.2019 / PubMed / Full text
Frailty biomarkers in humans and rodents: Current approaches and future advances. / 06.2019 / PubMed / Full text
Pregnancies alters spine number in cortical and subcortical limbic brain regions of old rats. / 08.2019 / PubMed / Full text
TrkB Activation during a Critical Period Mimics the Protective Effects of Early Visual Experience on Perception and the Stability of Receptive Fields in Adult Superior Colliculus. / 05.06.2019 / PubMed / Full text
Ageing of the somatosensory system at the periphery: age-related changes in cutaneous mechanoreceptors. / 06.2019 / PubMed / Full text
Hydrophilic Glycoproteins of an Edible Green Alga [i]Capsosiphon fulvescens[/i] Prevent Aging-Induced Spatial Memory Impairment by Suppressing GSK-3β-Mediated ER Stress in Dorsal Hippocampus. / 15.03.2019 / PubMed / Full text
β-Alanine supplementation reduces anxiety and increases neurotrophin expression in both young and older rats. / 02.2019 / PubMed / Full text
Structural and molecular correlates of cognitive aging in the rat. / 14.02.2019 / PubMed / Full text
Reduction of BDNF results in GABAergic neuroplasticity dysfunction and contributes to late-life anxiety disorder. / 04.2019 / PubMed / Full text
The Role of Enhanced Cognition to Counteract Detrimental Effects of Prolonged Bed Rest: Current Evidence and Perspectives. / 2018 / PubMed / Full text
A candidate gene study of risk for dementia in older, postmenopausal women: Results from the Women's Health Initiative Memory Study. / 05.2019 / PubMed / Full text
The TrkB-T1 receptor mediates BDNF-induced migration of aged cardiac microvascular endothelial cells by recruiting Willin. / 04.2019 / PubMed / Full text
Influence of BDNF Val66Met on the relationship between cardiorespiratory fitness and memory in cognitively normal older adults. / 19.04.2019 / PubMed / Full text
Emerging Anti-Aging Strategies - Scientific Basis and Efficacy. / 12.2018 / PubMed / Full text
Hypothalamic gene transfer of BDNF promotes healthy aging in mice. / 04.2019 / PubMed / Full text
Sex-dependent effect of the BDNF Val66Met polymorphism on executive functioning and processing speed in older adults: evidence from the health ABC study. / 02.2019 / PubMed / Full text
Brain-Derived Neurotrophic Factor and Its Associations with Metabolism and Physical Activity in a Latino Sample. / 03.2019 / PubMed / Full text
Exercise training increases cardiac, hepatic and circulating levels of brain-derived neurotrophic factor and irisin in young and aged rats. / 26.10.2018 / PubMed / Full text
RbAp48 Protein Is a Critical Component of GPR158/OCN Signaling and Ameliorates Age-Related Memory Loss. / 23.10.2018 / PubMed / Full text
Amygdala subnuclei and healthy cognitive aging. / 01.2019 / PubMed / Full text
BDNF trafficking and signaling impairment during early neurodegeneration is prevented by moderate physical activity. / 12.2016 / PubMed / Full text
Walnut diets up-regulate the decreased hippocampal neurogenesis and age-related cognitive dysfunction in d-galactose induced aged rats. / 19.09.2018 / PubMed / Full text
Genetics of stroke recovery: BDNF val66met polymorphism in stroke recovery and its interaction with aging. / 06.2019 / PubMed / Full text
Brain-Derived Neurotrophic Factor in Brain Disorders: Focus on Neuroinflammation. / 05.2019 / PubMed / Full text
Is Objectively Assessed Sedentary Behavior, Physical Activity and Cardiorespiratory Fitness Linked to Brain Plasticity Outcomes in Old Age? / 15.09.2018 / PubMed / Full text
Towards frailty biomarkers: Candidates from genes and pathways regulated in aging and age-related diseases. / 11.2018 / PubMed / Full text
Remodeling of myelinated fibers and internal capillaries in distal peripheral nerves following aerobic exercise in aged rats. / 01.10.2018 / PubMed / Full text
The Moderating Role of COMT and BDNF Polymorphisms on Transfer Effects Following Multi- and Single-Domain Cognitive Training Among Community-Dwelling Shanghainese Older Adults. / 2018 / PubMed / Full text
Soybean-Derived Glycine-Arginine Dipeptide Administration Promotes Neurotrophic Factor Expression in the Mouse Brain. / 01.08.2018 / PubMed / Full text
Brain-derived neurotrophic factor in serum as an animal welfare indicator of environmental enrichment in pigs. / 10.2018 / PubMed / Full text
Exercise Training Protects Against Aging-Induced Cognitive Dysfunction via Activation of the Hippocampal PGC-1α/FNDC5/BDNF Pathway. / 09.2018 / PubMed / Full text
The influence of aging on the methylation status of brain-derived neurotrophic factor gene in blood. / 10.2018 / PubMed / Full text
Surgical Trauma Exacerbates Cognitive Deficits and Neuroinflammation in Aged Rats: The Role of CX3CL1-CX3CR1 Signaling. / 01.08.2018 / PubMed / Full text
Long-Term Diet Supplementation with [i]Lactobacillus paracasei[/i] K71 Prevents Age-Related Cognitive Decline in Senescence-Accelerated Mouse Prone 8. / 13.06.2018 / PubMed / Full text
The Impact of Aging, Psychotic Symptoms, Medication, and Brain-Derived Neurotrophic Factor on Cognitive Impairment in Japanese Chronic Schizophrenia Patients. / 2018 / PubMed / Full text
Aging and an Immune Challenge Interact to Produce Prolonged, but Not Permanent, Reductions in Hippocampal L-LTP and mBDNF in a Rodent Model with Features of Delirium. / 05-06.2018 / PubMed / Full text
Genetic Risk for Age-Related Cognitive Impairment Does Not Predict Cognitive Performance in Middle Age. / 2018 / PubMed / Full text
Integrative Analysis of Hippocampus Gene Expression Profiles Identifies Network Alterations in Aging and Alzheimer's Disease. / 2018 / PubMed / Full text
The Gender-Biased Effects of Intranasal MPTP Administration on Anhedonic- and Depressive-Like Behaviors in C57BL/6 Mice: the Role of Neurotrophic Factors. / 11.2018 / PubMed / Full text
Differential effects of adolescent and adult-initiated voluntary exercise on context and cued fear conditioning. / 02.2019 / PubMed / Full text
Aerobic exercise upregulates the BDNF-Serotonin systems and improves the cognitive function in rats. / 11.2018 / PubMed / Full text
Analysis of neurotrophic and antioxidant factors related to midbrain dopamine neuronal loss and brain inflammation in the cerebrospinal fluid of the elderly. / 09.2018 / PubMed / Full text
The Aerobic and Cognitive Exercise Study (ACES) for Community-Dwelling Older Adults With or At-Risk for Mild Cognitive Impairment (MCI): Neuropsychological, Neurobiological and Neuroimaging Outcomes of a Randomized Clinical Trial. / 2018 / PubMed / Full text
The neuropeptide-12 improves recognition memory and neuronal plasticity of the limbic system in old rats. / 08.2018 / PubMed / Full text
The Role of Apolipoprotein E and Ethanol Exposure in Age-Related Changes in Choline Acetyltransferase and Brain-Derived Neurotrophic Factor Expression in the Mouse Hippocampus. / 05.2018 / PubMed / Full text
BDNF in the Aged Brain: Translational Implications for Parkinson's Disease. / 2017 / PubMed / Full text
Altered cardiovascular function is related to reduced BDNF in Parkinson's disease. / 05-06.2018 / PubMed / Full text
The Melatonin Signaling Pathway in a Long-Term Memory In Vitro Study. / 23.03.2018 / PubMed / Full text
An acute bout of aerobic or strength exercise specifically modifies circulating exerkine levels and neurocognitive functions in elderly individuals with mild cognitive impairment. / 2018 / PubMed / Full text
Metformin ameliorates the age-related changes of d-galactose administration in ovariectomized mice. / 08.2018 / PubMed / Full text
Aerobic and strength training induce changes in oxidative stress parameters and elicit modifications of various cellular components in skeletal muscle of aged rats. / 06.2018 / PubMed / Full text
GPR30 activation improves memory and facilitates DHPG-induced LTD in the hippocampal CA3 of middle-aged mice. / 03.2018 / PubMed / Full text
Buttermilk and Krill Oil Phospholipids Improve Hippocampal Insulin Resistance and Synaptic Signaling in Aged Rats. / 09.2018 / PubMed / Full text
The role of hippocampal brain-derived neurotrophic factor in age-related differences in neuropathic pain behavior in rats. / 15.03.2018 / PubMed / Full text
Sex Differences in the Impact of BDNF Genotype on the Longitudinal Relationship between Physical Activity and Cognitive Performance. / 2018 / PubMed / Full text
Protective effect of metformin on D-galactose-induced aging model in mice. / 01.2018 / PubMed / Full text
The Effects of Physical Training are Varied and Occur in an Exercise Type-Dependent Manner in Elderly Men. / 12.2017 / PubMed / Full text
Exenatide exerts cognitive effects by modulating the BDNF-TrkB neurotrophic axis in adult mice. / 04.2018 / PubMed / Full text
Candidate molecular pathways of white matter vulnerability in the brain of normal aging rhesus monkeys. / 02.2018 / PubMed / Full text
Lifespan leisure physical activity profile, brain plasticity and cognitive function in old age. / 07.2019 / PubMed / Full text
A noradrenergic lesion aggravates the effects of systemic inflammation on the hippocampus of aged rats. / 2017 / PubMed / Full text
Genetic Biomarkers on Age-Related Cognitive Decline. / 2017 / PubMed / Full text
Effects of cerebrolysin on nerve growth factor system in the aging rat brain. / 2017 / PubMed / Full text
Repeated exposure to sevoflurane impairs the learning and memory of older male rats. / 01.01.2018 / PubMed / Full text
Interaction between [i]BDNF[/i] Polymorphism and Physical Activity on Inhibitory Performance in the Elderly without Cognitive Impairment. / 2017 / PubMed / Full text
Exercise enhances cognitive function and neurotrophin expression in the hippocampus accompanied by changes in epigenetic programming in senescence-accelerated mice. / 05.02.2018 / PubMed / Full text
Age-related changes in STriatal-Enriched protein tyrosine Phosphatase levels: Regulation by BDNF. / 01.2018 / PubMed / Full text
Brain-Derived Neurotrophic Factor in Patients with Primary Open-Angle Glaucoma and Age-related Cataract. / 02.2018 / PubMed / Full text
Nicotine-Induced Neuroprotection against Cognitive Dysfunction after Partial Hepatectomy Involves Activation of BDNF/TrkB Signaling Pathway and Inhibition of NF-κB Signaling Pathway in Aged Rats. / 06.03.2018 / PubMed / Full text
Protective effect of xanthohumol against age-related brain damage. / 11.2017 / PubMed / Full text
Effects of aerobic exercise on brain metabolism and grey matter volume in older adults: results of the randomised controlled SMART trial. / 18.07.2017 / PubMed / Full text
Differential deregulation of NGF and BDNF neurotrophins in a transgenic rat model of Alzheimer's disease. / 12.2017 / PubMed / Full text
Walking speed decline in older adults is associated with elevated pro-BDNF in plasma extracellular vesicles. / 11.2017 / PubMed / Full text
Exercise training with concomitant nitric oxide synthase inhibition improved anxiogenic behavior, spatial cognition, and BDNF/P70S6 kinase activation in 20-month-old rats. / 01.2018 / PubMed / Full text
Chronic fluoxetine ameliorates adolescent chronic nicotine exposure-induced long-term adult deficits in trace conditioning. / 10.2017 / PubMed / Full text
Spontaneous physical activity and mediators of energy homeostasis in the hypothalamus of mice from 4 to 10 months of age. / 01.11.2017 / PubMed / Full text

CA1

The relation between tau pathology and granulovacuolar degeneration of neurons. / 01.2021 / PubMed / Full text
Memory and dendritic spines loss, and dynamic dendritic spines changes are age-dependent in the rat. / 12.2020 / PubMed / Full text
Deregulated expression of a longevity gene, Klotho, in the C9orf72 deletion mice with impaired synaptic plasticity and adult hippocampal neurogenesis. / 04.09.2020 / PubMed / Full text
COX5A Plays a Vital Role in Memory Impairment Associated With Brain Aging [i]via[/i] the BDNF/ERK1/2 Signaling Pathway. / 2020 / PubMed / Full text
Changes of fat-mass and obesity-associated protein expression in the hippocampus in animal models of high-fat diet-induced obesity and D-galactose-induced aging. / 2020 / PubMed / Full text
Phenylbutyrate ameliorates prefrontal cortex, hippocampus, and nucleus accumbens neural atrophy as well as synaptophysin and GFAP stress in aging mice. / 11.2020 / PubMed / Full text
Heterogeneity in brain distribution of activated microglia and astrocytes in a rat ischemic model of Alzheimer's disease after 2 years of survival. / 05.06.2020 / PubMed / Full text
Hippocampal Subregion Transcriptomic Profiles Reflect Strategy Selection during Cognitive Aging. / 17.06.2020 / PubMed / Full text
Associations between pattern separation and hippocampal subfield structure and function vary along the lifespan: A 7 T imaging study. / 05.05.2020 / PubMed / Full text
Laminarin Pretreatment Provides Neuroprotection against Forebrain Ischemia/Reperfusion Injury by Reducing Oxidative Stress and Neuroinflammation in Aged Gerbils. / 15.04.2020 / PubMed / Full text
Age-dependent Alteration in Mitochondrial Dynamics and Autophagy in Hippocampal Neuron of Cannabinoid CB1 Receptor-deficient Mice. / 07.2020 / PubMed / Full text
Functional Connectivity of Hippocampal CA3 Predicts Neurocognitive Aging via CA1-Frontal Circuit. / 30.06.2020 / PubMed / Full text
Integration of qRT-PCR and Immunohistochemical Techniques for mRNA Expression and Localization of m1AChR in the Brain of Aging Rat. / 2020 / PubMed / Full text
Role of Eclipta prostrata extract in improving spatial learning and memory deficits in D-galactose-induced aging in rats. / 10.2019 / PubMed
Differential annualized rates of hippocampal subfields atrophy in aging and future Alzheimer's clinical syndrome. / 06.2020 / PubMed / Full text
Rectification of radiotherapy-induced cognitive impairments in aged mice by reconstituted Sca-1 stem cells from young donors. / 07.02.2020 / PubMed / Full text
Increasing neurogenesis refines hippocampal activity rejuvenating navigational learning strategies and contextual memory throughout life. / 09.01.2020 / PubMed / Full text
Memory Performance Correlates of Hippocampal Subfield Volume in Mild Cognitive Impairment Subtype. / 2019 / PubMed / Full text
Spermidine protects from age-related synaptic alterations at hippocampal mossy fiber-CA3 synapses. / 23.12.2019 / PubMed / Full text
Methylene blue inhibits Caspase-6 activity, and reverses Caspase-6-induced cognitive impairment and neuroinflammation in aged mice. / 16.12.2019 / PubMed / Full text
Long-term Memory Upscales Volume of Postsynaptic Densities in the Process that Requires Autophosphorylation of αCaMKII. / 14.04.2020 / PubMed / Full text
PACAP27 mitigates an age-dependent hippocampal vulnerability to PGJ2-induced spatial learning deficits and neuroinflammation in mice. / 01.2020 / PubMed / Full text
Inhibition of oxidative stress by testosterone improves synaptic plasticity in senescence accelerated mice. / 2019 / PubMed / Full text
Restored presynaptic synaptophysin and cholinergic inputs contribute to the protective effects of physical running on spatial memory in aged mice. / 12.2019 / PubMed / Full text
Senescent neurophysiology: Ca signaling from the membrane to the nucleus. / 10.2019 / PubMed / Full text
Dissociable age and memory relationships with hippocampal subfield volumes in vivo:Data from the Irish Longitudinal Study on Ageing (TILDA). / 29.07.2019 / PubMed / Full text
GABA Receptors Are Well Preserved in the Hippocampus of Aged Mice. / 07-08.2019 / PubMed / Full text
Changes in presynaptic calcium signalling accompany age-related deficits in hippocampal LTP and cognitive impairment. / 10.2019 / PubMed / Full text
Sleep Deprivation by Exposure to Novel Objects Increases Synapse Density and Axon-Spine Interface in the Hippocampal CA1 Region of Adolescent Mice. / 21.08.2019 / PubMed / Full text
Transmission Electron Microscopy Study of Mitochondria in Aging Brain Synapses. / 11.06.2019 / PubMed / Full text
Subcortical amyloid load is associated with shape and volume in cognitively normal individuals. / 09.2019 / PubMed / Full text
Effects of Long-Term Moderate Intensity Exercise on Cognitive Behaviors and Cholinergic Forebrain in the Aging Rat. / 15.07.2019 / PubMed / Full text
Functional connectivity along the anterior-posterior axis of hippocampal subfields in the ageing human brain. / 11.2019 / PubMed / Full text
[Improved effects of saponins from Panax japonicus on decline of cognitive function in natural aging rats via NLRP3 inflammasome pathway]. / 01.2019 / PubMed / Full text
Pregnancies alters spine number in cortical and subcortical limbic brain regions of old rats. / 08.2019 / PubMed / Full text
Systemic administration of a fibroblast growth factor receptor 1 agonist rescues the cognitive deficit in aged socially isolated rats. / 06.2019 / PubMed / Full text
Cellular and Molecular Differences Between Area CA1 and the Dentate Gyrus of the Hippocampus. / 09.2019 / PubMed / Full text
Regional vulnerability and spreading of hyperphosphorylated tau in seeded mouse brain. / 07.2019 / PubMed / Full text
Loss of C/EBPδ Exacerbates Radiation-Induced Cognitive Decline in Aged Mice due to Impaired Oxidative Stress Response. / 18.02.2019 / PubMed / Full text
Experimental pediatric stroke shows age-specific recovery of cognition and role of hippocampal Nogo-A receptor signaling. / 03.2020 / PubMed / Full text
A Key Role for Subiculum-Fornix Connectivity in Recollection in Older Age. / 2018 / PubMed / Full text
Impaired fear memory extinction during adolescence is accompanied by the depressive-like behaviors. / 23.04.2019 / PubMed / Full text
Age-Related Cognitive Impairment: Role of Reduced Synaptobrevin-2 Levels in Deficits of Memory and Synaptic Plasticity. / 16.09.2020 / PubMed / Full text
Astrocytic changes with aging and Alzheimer's disease-type pathology in chimpanzees. / 01.05.2019 / PubMed / Full text
Differential Progression of Regional Hippocampal Atrophy in Aging and Parkinson's Disease. / 2018 / PubMed / Full text
The Volume of Hippocampal Subfields in Relation to Decline of Memory Recall Across the Adult Lifespan. / 2018 / PubMed / Full text
Alzheimer's Disease Biomarkers Have Distinct Associations with Specific Hippocampal Subfield Volumes. / 2018 / PubMed / Full text
Long-Term Consolidation of Ensemble Neural Plasticity Patterns in Hippocampal Area CA1. / 16.10.2018 / PubMed / Full text
Age-Induced Spatial Memory Deficits in Rats Are Correlated with Specific Brain Region Alterations in Microglial Morphology and Gene Expression. / 06.2019 / PubMed / Full text
Dexpramipexole enhances hippocampal synaptic plasticity and memory in the rat. / 12.2018 / PubMed / Full text
Early disruption of parvalbumin expression and perineuronal nets in the hippocampus of the Tg2576 mouse model of Alzheimer's disease can be rescued by enriched environment. / 12.2018 / PubMed / Full text
Relative neuron loss in hippocampal sclerosis of aging and Alzheimer's disease. / 11.2018 / PubMed / Full text
Vitamin D deficiency is associated with reduced hippocampal volume and disrupted structural connectivity in patients with mild cognitive impairment. / 01.02.2019 / PubMed / Full text
[AGE-RELATED CHANGES IN THE MORPHOMETRIC PARAMETERS OF THE NEURONS IN HUMAN HIPPOCAMPUS]. / 2016 / PubMed
Loss of thin spines and small synapses contributes to defective hippocampal function in aged mice. / 11.2018 / PubMed / Full text
Microglia changes associated to Alzheimer's disease pathology in aged chimpanzees. / 15.12.2018 / PubMed / Full text
Nonsteroidal anti-inflammatory drug, indomethacin improves spatial memory and NMDA receptor function in aged animals. / 10.2018 / PubMed / Full text
Dissociable effects of advanced age on prefrontal cortical and medial temporal lobe ensemble activity. / 10.2018 / PubMed / Full text
Enhanced postsynaptic inhibitory strength in hippocampal principal cells in high-performing aged rats. / 10.2018 / PubMed / Full text
Association between age‑related hearing loss and cognitive decline in C57BL/6J mice. / 08.2018 / PubMed / Full text
Store depletion-induced h-channel plasticity rescues a channelopathy linked to Alzheimer's disease. / 10.2018 / PubMed / Full text
Aging and an Immune Challenge Interact to Produce Prolonged, but Not Permanent, Reductions in Hippocampal L-LTP and mBDNF in a Rodent Model with Features of Delirium. / 05-06.2018 / PubMed / Full text
Nrf2 Deficiency Exacerbates Obesity-Induced Oxidative Stress, Neurovascular Dysfunction, Blood-Brain Barrier Disruption, Neuroinflammation, Amyloidogenic Gene Expression, and Cognitive Decline in Mice, Mimicking the Aging Phenotype. / 14.06.2018 / PubMed / Full text
Aerobic exercise upregulates the BDNF-Serotonin systems and improves the cognitive function in rats. / 11.2018 / PubMed / Full text
Loss of calretinin and parvalbumin positive interneurones in the hippocampal CA1 of aged Alzheimer's disease mice. / 10.08.2018 / PubMed / Full text
Long-Term Moderate Exercise Rescues Age-Related Decline in Hippocampal Neuronal Complexity and Memory. / 2018 / PubMed / Full text
Stereological Investigation of the Effects of Treadmill Running Exercise on the Hippocampal Neurons in Middle-Aged APP/PS1 Transgenic Mice. / 2018 / PubMed / Full text
Hippocampal Sclerosis in the Oldest Old: A Finnish Population-Based Study. / 2018 / PubMed / Full text
Inosine improves cognitive function and decreases aging-induced oxidative stress and neuroinflammation in aged female rats. / 10.2018 / PubMed / Full text
Dynamic SAP102 expression in the hippocampal subregions of rats and APP/PS1 mice of various ages. / 06.2018 / PubMed / Full text
Characterizing the human hippocampus in aging and Alzheimer's disease using a computational atlas derived from ex vivo MRI and histology. / 17.04.2018 / PubMed / Full text
Incomplete Hippocampal Inversion and Its Relationship to Hippocampal Subfield Volumes and Aging. / 07.2018 / PubMed / Full text
Protracted hippocampal development is associated with age-related improvements in memory during early childhood. / 01.07.2018 / PubMed / Full text
Age-dependent changes in vesicular glutamate transporter 1 and 2 expression in the gerbil hippocampus. / 05.2018 / PubMed / Full text
PGE2-EP3 signaling exacerbates hippocampus-dependent cognitive impairment after laparotomy by reducing expression levels of hippocampal synaptic plasticity-related proteins in aged mice. / 10.2018 / PubMed / Full text
Downregulated Nuclear Factor E2-Related Factor 2 (Nrf2) Aggravates Cognitive Impairments via Neuroinflammation and Synaptic Plasticity in the Senescence-Accelerated Mouse Prone 8 (SAMP8) Mouse: A Model of Accelerated Senescence. / 23.02.2018 / PubMed / Full text
GPR30 activation improves memory and facilitates DHPG-induced LTD in the hippocampal CA3 of middle-aged mice. / 03.2018 / PubMed / Full text
CA1 pyramidal neuron gene expression mosaics in the Ts65Dn murine model of Down syndrome and Alzheimer's disease following maternal choline supplementation. / 04.2018 / PubMed / Full text
Protective Effect of Klotho against Ischemic Brain Injury Is Associated with Inhibition of RIG-I/NF-κB Signaling. / 2017 / PubMed / Full text
Long-term treadmill exercise improves memory impairment through restoration of decreased synaptic adhesion molecule 1/2/3 induced by transient cerebral ischemia in the aged gerbil hippocampus. / 03.2018 / PubMed / Full text
Prenatal exposure to valproic acid alters the development of excitability in the postnatal rat hippocampus. / 03.2018 / PubMed / Full text
Neurodevelopment and behavior in neonatal OXYS rats with genetically determined accelerated senescence. / 15.02.2018 / PubMed / Full text
Hippocampal Transcriptomic Profiles: Subfield Vulnerability to Age and Cognitive Impairment. / 2017 / PubMed / Full text
Myelin changes at the early stage of 5XFAD mice. / 03.2018 / PubMed / Full text
DPP-4 inhibition with linagliptin ameliorates the progression of premature aging in klotho-/- mice. / 01.12.2017 / PubMed / Full text
Antioxidant action of grape seed polyphenols and aerobic exercise in improving neuronal number in the hippocampus is associated with decrease in lipid peroxidation and hydrogen peroxide in adult and middle-aged rats. / 01.2018 / PubMed / Full text
Local Inhibition of PERK Enhances Memory and Reverses Age-Related Deterioration of Cognitive and Neuronal Properties. / 17.01.2018 / PubMed / Full text
Effect of Chronic Administration of Resveratrol on Cognitive Performance during Aging Process in Rats. / 2017 / PubMed / Full text
Age-related epigenetic changes in hippocampal subregions of four animal models of Alzheimer's disease. / 01.2018 / PubMed / Full text
Time of day but not aging regulates 5-HT receptor binding sites in the hamster hippocampus. / 01.01.2018 / PubMed / Full text
Cytoarchitectonically-driven MRI atlas of nonhuman primate hippocampus: Preservation of subfield volumes in aging. / 05.2019 / PubMed / Full text
Individual differences in associative memory among older adults explained by hippocampal subfield structure and function. / 07.11.2017 / PubMed / Full text
Nicotine-Induced Neuroprotection against Cognitive Dysfunction after Partial Hepatectomy Involves Activation of BDNF/TrkB Signaling Pathway and Inhibition of NF-κB Signaling Pathway in Aged Rats. / 06.03.2018 / PubMed / Full text
Age-dependent differences in myelin basic protein expression in the hippocampus of young, adult and aged gerbils. / 09.2017 / PubMed / Full text
Grape Seed Proanthocyanidin and Swimming Exercise Protects Against Cognitive Decline: A Study on M1 Acetylcholine Receptors in Aging Male Rat Brain. / 12.2017 / PubMed / Full text
Aging dependent effect of nuclear tau. / 15.12.2017 / PubMed / Full text
Dopamine D4 receptor activation restores CA1 LTP in hippocampal slices from aged mice. / 12.2017 / PubMed / Full text
CA1 pyramidal cells have diverse biophysical properties, affected by development, experience, and aging. / 2017 / PubMed / Full text
Temporal binding function of dorsal CA1 is critical for declarative memory formation. / 19.09.2017 / PubMed / Full text
Hippocampal sclerosis, hippocampal neuron loss patterns and TDP-43 in the aged population. / 07.2018 / PubMed / Full text
Distribution of corticotropin-releasing factor receptor 1 in the developing mouse forebrain: A novel sex difference revealed in the rostral periventricular hypothalamus. / 11.10.2017 / PubMed / Full text
Clinical-grade human umbilical cord-derived mesenchymal stem cells reverse cognitive aging via improving synaptic plasticity and endogenous neurogenesis. / 10.08.2017 / PubMed / Full text

Aging genes 100: различия между версиями

Версия от 14:41, 31 марта 2021

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