CYP2C9

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Cytochrome P450 2C9 (EC 1.14.14.1) ((R)-limonene 6-monooxygenase) (EC 1.14.14.53) ((S)-limonene 6-monooxygenase) (EC 1.14.14.51) ((S)-limonene 7-monooxygenase) (EC 1.14.14.52) (CYPIIC9) (Cholesterol 25-hydroxylase) (Cytochrome P-450MP) (Cytochrome P450 MP-4) (Cytochrome P450 MP-8) (Cytochrome P450 PB-1) (S-mephenytoin 4-hydroxylase) [CYP2C10]

Publications[править]

Pediatric Cytochrome P450 Activity Alterations in Nonalcoholic Steatohepatitis.


Determination of Human Hepatic CYP2C8 and CYP1A2 Age-Dependent Expression to Support Human Health Risk Assessment for Early Ages.


Genotype-based dosage of acenocoumarol in highly-sensitive geriatric patients.


The effect of CYP2C9, VKORC1 genotypes and old age on warfarin pharmacologic sensitivity in korean patients with thromboembolic disease.


Genetic variation in the CYP2C monooxygenase enzyme subfamily shows no association with longevity in a German population.


Eight common genetic variants associated with serum DHEAS levels suggest a key role in ageing mechanisms.


Contribution of age, body weight, and CYP2C9 and VKORC1 genotype to the anticoagulant response to warfarin: proposal for a new dosing regimen in Chinese patients.


A PK-PD model for predicting the impact of age, CYP2C9, and VKORC1 genotype on individualization of warfarin therapy.


Influence of CYP2C9 polymorphisms, demographic factors and concomitant drug therapy on warfarin metabolism and maintenance dose.


The effects of gender, age, ethnicity, and liver cirrhosis on cytochrome P450 enzyme activity in human liver microsomes and inducibility in cultured human hepatocytes.


Contribution of age, body size, and CYP2C9 genotype to anticoagulant response to warfarin.


Influence of age and cytochrome P450 2C9 genotype on the steady-state disposition of diclofenac and celecoxib.


Treatment of the elderly with 3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitors: focus on drug interactions.


Interindividual variability in sensitivity to warfarin--Nature or nurture?


The selective serotonin reuptake inhibitor sertraline: its profile and use in psychiatric disorders.


In vivo age-related changes in hepatic drug-oxidizing capacity in humans.


Developmental expression of CYP2C and CYP2C-dependent activities in the human liver: in-vivo/in-vitro correlation and inducibility.