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...[DYRK3]] promote cell survival through phosphorylation and activation of [[SIRT1]]. ...ptotic DYRK members promote cell survival through direct modification of [[SIRT1]]. These findings may have important implications in understanding the mole ...

|title=A [[SIRT1]]-centered circuitry regulates breast cancer stemness and metastasis. ...to Paclitaxel and improves therapeutic effects. Our findings delineate a [[SIRT1]]-centered circuitry that regulates CSC origination, and targeting this pat ...

|title=Endothelial [[SIRT1]] prevents adverse arterial remodeling by facilitating [[HERC2]]-mediated d ...trol.Conclusion-By downregulating acetylated LKB1 protein via [[HERC2]], [[SIRT1]] fine-tunes the crosstalk between endothelial and vascular smooth muscle c ...

...tion delays senescence and promotes proliferation of HUVECs via the AMPK/[[SIRT1]]-[[FOXA3]]-Beclin1 pathway. ...inhibit senescence, and enhance proliferation of HUVECs through the AMPK/[[SIRT1]]-[[FOXA3]]-Beclin1 pathway. ...

...e and function of EPCs through the VEGF/[[KDR]] pathway by activation of [[SIRT1]]. |keywords=* SIRT1 ...

...by the [[CCAR2]] ortholog, CCAR-1. This negative regulation requires the [[SIRT1]] homolog SIR-2.1. In addition, knockdown of CCAR-1 via ccar-1 RNAi works t ...

|title=[[SIRT1]] protects cochlear hair cell and delays age-related hearing loss via autop ...n elucidating the link between ER stress and autophagy in aging. Because [[SIRT1]] activation restores autophagy with reduced HC death and hearing loss, it ...

...cid acts on NRF2 expression, and in turn to the actions of GRα, [[GDF11]], Sirt1, and Sirt6. Regarding the increased expression of Per1, the activation effe ...

|title=Tumor suppressor [[HIC1]] directly regulates [[SIRT1]] to modulate p53-dependent DNA-damage responses. ...c silencing of [[HIC1]], we speculate that the resultant upregulation of [[SIRT1]] may be a double-edged sword that both promotes survival of aging cells an ...

.... The three down-regulated mRNA in cellular aging, [[ELK1]], [[FOS]] and [[SIRT1]], were increased with tocotrienol-rich fraction treatment. Expression of [ ...

...e and function of EPCs through the VEGF/[[KDR]] pathway by activation of [[SIRT1]]. |keywords=* SIRT1 ...

...ression of p21, PAI-1, and K382 acetylation of p53 as well as reduction of Sirt1. The knockdown of TRG5 abolished the protective role of INT-777 on these mo * Sirt1 ...

...rucial mediator in the renal aging process. Furthermore, manipulation of [[SIRT1]] activity by NMN seems to be a potential pharmaceutical intervention for A * SIRT1 ...

...iR-302b-3p inhibitor could delay skin fibroblast senescence and contribute Sirt1 expression. In addition, we demonstrated that c-Jun N-terminal kinase 2(JNK ...

...rlying mechanism remains elusive. Here, we report that Sirtinol, a known [[SIRT1]] inhibitor, induces premature senescence and growth arrest in K562 CML cel * SIRT1 ...

...ting the intracellular Sirt1-FOXO3a-[[SOD2]] axis. Moreover, the inhibited Sirt1 expression was related to the decreased mitochondrial function and the lowe ...

...erum deprivation and high confluency caused nuclear translocation of the [[SIRT1]]-regulated transcription factor FOXO3a. Our data indicate resveratrol's ac ...

|title=Dexamethasone downregulates [[SIRT1]] and [[IL6]] and upregulates [[EDN1]] genes in stem cells derived from gin ...]] was increased. Application of dexamethasone reduced the expression of [[SIRT1]] and [[IL6]] but enhanced the expression of [[EDN1]] of stem cells. ...

...s. The expression levels of Ac-histone H3, [[HDAC1]], [[HAT1]], p300 and [[SIRT1]] were increased in HT1080 cells treated with spermine. In addition, the ex * SIRT1 ...

...hylation of H3K79 (H3K79me3). Treatment of cells with either siAMPK or si[[SIRT1]] repressed [[DOT1L]]-mediated enhancement of H3K79me3. Moreover, the incre ...

...from hepatitis C virus infection-associated senescence via ΔNp63-miR-181a-Sirt1 pathway. ...umber of Foxp3 effector T (T ) cells upon manipulating the ΔNp63-miR-181a-Sirt1 pathway. In conclusion, these findings provide novel mechanistic insights i ...

.... IGF-I levels were lower in RasGrf1(-/-) than in controls. Furthermore, [[SIRT1]] expression was increased in RasGrf1(-/-) animals. Consistent with this, t ...

.... In addition, 64 SNPs loci distributed in 13 candidate genes [[FOXO3]], [[SIRT1]], [[TOMM40]], [[APOE]], [[PICALM]], [[COMT]], [[CETP]], [[CLU]], [[CR1]], ...

...[[DLC1]] promoted senescence through FoxO3a/NF-κB signaling mediated by [[SIRT1]] after resveratrol treatment. Finally, resveratrol increased ROS productio * SIRT1 ...

...levels) in parallel to decreased H S production and rejuvenation (LC3 and SIRT1)-related gene expression. In addition, [[CBS]] gene KD in ASC52telo cells r ...

...with antibodies for p21, p16, and β-galactosidase (senescence); for LC3, [[SIRT1]], [[MAP1S]], and pAMKα (autophagy); and for LDH and GLUT1 (metabolism). E ...

* SIRT1 |title=Negative reciprocal regulation between Sirt1 and Per2 modulates the circadian clock and aging. ...

...s, Cyclin A2, Cyclin D1, [[CDK2]], [[CDK6]], [[ETS1]], [[NBN]], [[RB1]], [[SIRT1]], were down-regulated. The increase in cyclin-dependent kinase inhibitors ...

...abolism. EGCG significantly increased the protein expression of [[FOXO1]], Sirt1, [[CAT]], [[FABP1]], [[GSTA2]], [[ACSL1]] and [[CPT2]] but significantly de ...

...es treated with the NAD [[SIRT1]] cofactor, than in cells treated with a [[SIRT1]] inhibitor. Inhibition of importin β by importazole maintained [[SOX9]] i * SIRT1 ...

...myocardial contractile function with adaptive cardiac remodeling: role of Sirt1-mediated autophagy regulation. ...ctile dysfunction and loss of mitophagy were improved by rapamycin and the Sirt1 activator SRT1720. Activation of Akt using insulin or Parkin deficiency pre ...

...ed galactosidase, beta 1; SASP: senescence-associated secretory phenotype; SIRT1: sirtuin 1; Spautin 1: specific and potent autophagy inhibitor 1; [[SQSTM1] ...ated changes in cathepsin D levels in humans and the association between [[SIRT1]] and eNOS. ...

...rotein kinases and other factors, such as mTOR, [[ULK1]], [[HDAC5]], and [[SIRT1]]. Given that AMPK and HIF activation can enhance not only healthspan and l ...el of NAD( ). NAD( ) is a substrate for nuclear sirtuins, especially for [[SIRT1]] and [[SIRT6]], which deacetylate histones and transcription factors, e.g. ...

...the 4 potential candidate genes [[ETV1]], [[ONECUT1]], [[MACROD2]], and [[SIRT1]], which directly (via disease resistance mechanisms) or indirectly (via mi ...

|title=[[SIRT1]] - a new mammalian substrate of nuclear autophagy. ...er substrate of nuclear autophagy and suggests a new strategy to promote [[SIRT1]]-mediated health benefits by suppressing its autophagic degradation. ...

|title=Loss-of-[[SIRT1]] function during vascular ageing: hyperphosphorylation mediated by cyclin- ...[[SIRT1]] function during vascular ageing. Thus, by inhibiting [[CDK5]], [[SIRT1]] function can be improved, in turn preventing the development of atheroscl ...

...se receiving the LP diet. Furthermore, [[HP]] feeding increased relative [[SIRT1]] mRNA levels. Additional mechanistic cell culture experiments were perform ...

...by the [[CCAR2]] ortholog, CCAR-1. This negative regulation requires the [[SIRT1]] homolog SIR-2.1. In addition, knockdown of CCAR-1 via ccar-1 RNAi works t ...Fs and Hsps in skeletal muscle. We studied the protein levels of sirtuins (SIRT1, [[SIRT2]], [[SIRT3]], [[SIRT4]], [[SIRT5]], [[SIRT6]] and SIRT7), [[HSF1]] ...

...at melatonin may help the hippocampal neuronal homeostasis by increasing [[SIRT1]], [[FOXO1]] and melatonin receptors expression while decreasing [[DKK1]] e ...

...and BAT weight). In addition, mitochondrial biogenesis proteins (PGC-1α, [[SIRT1]], and pAMPK) and respiratory chain activity (complexes I, II/III, III, and ...

...production of melanin were investigated. Enzymatic activity of sirtuin 1 (SIRT1) after treatment with PTP20 was also determined. Ex vivo studies using huma ...

...on of senescence-associated beta-galactosidase, and loss of phosphorylated Sirt1 . Furthermore, we also demonstrate that JQ1 was efficient in reducing the p ...

...abolism. EGCG significantly increased the protein expression of [[FOXO1]], Sirt1, [[CAT]], [[FABP1]], [[GSTA2]], [[ACSL1]] and [[CPT2]] but significantly de ...

...of NAD. On the other hand, NGD and NHD cannot be used as substrates for [[SIRT1]], [[SIRT3]], and [[PARP1]]. These results reveal the basic metabolism of N ...progenitor cells by preserving intracellular NAD levels and increasing [[SIRT1]] activity. ...

...ed galactosidase, beta 1; SASP: senescence-associated secretory phenotype; SIRT1: sirtuin 1; Spautin 1: specific and potent autophagy inhibitor 1; [[SQSTM1] ...

...on tumorigenesis has yet to be elucidated. Previous studies focusing on [[SIRT1]], do not support a critical role for this sirtuin family member in CR-medi |title=Hsp90 Stabilizes [[SIRT1]] Orthologs in Mammalian Cells and [i]C. elegans[/i]. ...

...[[FEN1]], [[DNA2]], RecQ helicases, Top2α, Top2β, [[TOP3A]], DNMT1/3a/3b, SIRT1). In addition, specialized telomeric proteins, such as [[TERT]] (telomerase ...

...pophagy and senescence. Taken together, our findings demonstrate a novel [[SIRT1]]/[[LAMP1]]/lipophagy axis mediating AGG-induced senescence in prostate can * SIRT1 ...

...PER, [[CLOCK]], BMAL1, ROR, and clock-controlled proteins like [[AVP]], [[SIRT1]], FOXO, and PK2 towards future approaches for management of AD. Furthermor |title=[[SIRT1]] mediates central circadian control in the SCN by a mechanism that decays ...

...tive aging and glucose overload can be prevented by optimizing the Nampt-[[SIRT1]] axis. ...