Результаты поиска

...production of melanin were investigated. Enzymatic activity of sirtuin 1 (SIRT1) after treatment with PTP20 was also determined. Ex vivo studies using huma ...

...on of senescence-associated beta-galactosidase, and loss of phosphorylated Sirt1 . Furthermore, we also demonstrate that JQ1 was efficient in reducing the p ...

...abolism. EGCG significantly increased the protein expression of [[FOXO1]], Sirt1, [[CAT]], [[FABP1]], [[GSTA2]], [[ACSL1]] and [[CPT2]] but significantly de ...

...of NAD. On the other hand, NGD and NHD cannot be used as substrates for [[SIRT1]], [[SIRT3]], and [[PARP1]]. These results reveal the basic metabolism of N ...progenitor cells by preserving intracellular NAD levels and increasing [[SIRT1]] activity. ...

...ed galactosidase, beta 1; SASP: senescence-associated secretory phenotype; SIRT1: sirtuin 1; Spautin 1: specific and potent autophagy inhibitor 1; [[SQSTM1] ...

...on tumorigenesis has yet to be elucidated. Previous studies focusing on [[SIRT1]], do not support a critical role for this sirtuin family member in CR-medi |title=Hsp90 Stabilizes [[SIRT1]] Orthologs in Mammalian Cells and [i]C. elegans[/i]. ...

...[[FEN1]], [[DNA2]], RecQ helicases, Top2α, Top2β, [[TOP3A]], DNMT1/3a/3b, SIRT1). In addition, specialized telomeric proteins, such as [[TERT]] (telomerase ...

...pophagy and senescence. Taken together, our findings demonstrate a novel [[SIRT1]]/[[LAMP1]]/lipophagy axis mediating AGG-induced senescence in prostate can * SIRT1 ...

...PER, [[CLOCK]], BMAL1, ROR, and clock-controlled proteins like [[AVP]], [[SIRT1]], FOXO, and PK2 towards future approaches for management of AD. Furthermor |title=[[SIRT1]] mediates central circadian control in the SCN by a mechanism that decays ...

...tive aging and glucose overload can be prevented by optimizing the Nampt-[[SIRT1]] axis. ...

...Fs and Hsps in skeletal muscle. We studied the protein levels of sirtuins (SIRT1, [[SIRT2]], [[SIRT3]], [[SIRT4]], [[SIRT5]], [[SIRT6]] and SIRT7), [[HSF1]] ...

...abolism. EGCG significantly increased the protein expression of [[FOXO1]], Sirt1, [[CAT]], [[FABP1]], [[GSTA2]], [[ACSL1]] and [[CPT2]] but significantly de ...ere and telomerase, PPAR-α, GLUTs, [[FOXO1]], caspase-3, bcl-2, along with SIRT1/AMPK, PI3K/Akt, NF-κB, and insulin/insulin-like growth factor-1 pathways a ...

...s, Cyclin A2, Cyclin D1, [[CDK2]], [[CDK6]], [[ETS1]], [[NBN]], [[RB1]], [[SIRT1]], were down-regulated. The increase in cyclin-dependent kinase inhibitors ...

...s with SEN sEVs induced a miR-21/miR-217-related impairment of [[DNMT1]]-[[SIRT1]] expression, the reduction of proliferation markers, the acquisition of a * SIRT1 ...

...[[FEN1]], [[DNA2]], RecQ helicases, Top2α, Top2β, [[TOP3A]], DNMT1/3a/3b, SIRT1). In addition, specialized telomeric proteins, such as [[TERT]] (telomerase ...

...[[FGFR4]] signaling-activated PDAC cells. Furthermore, downregulation of [[SIRT1]] and [[SIRT6]] by BLU9931 contributed to senescence induction, priming the ...

...binding, ERK 1/2 activation, IL-8 release and mRNA levels but decreased [[SIRT1]], [[HDAC2]], [[HDAC3]] and FoxO3 nuclear expression. Combined therapy with ...

...erine-threonine kinase(Akt)/mTOR,the AMPK/silent information regulation 1 (Sirt1) and transforming growth factor β (TGF-β) play the important roles in ren ...

...abolism. EGCG significantly increased the protein expression of [[FOXO1]], Sirt1, [[CAT]], [[FABP1]], [[GSTA2]], [[ACSL1]] and [[CPT2]] but significantly de ...

...sms and pathways that are associated with the neuroprotective effects of [[SIRT1]]. ...is devastating condition. On the other hand, therapeutic upregulation of [[SIRT1]] might provide opportunities for the amelioration of Alzheimer's-disease-t ...