Aging genes 90-99

SIRT3Править

SIRT3 protects endothelial cells from high glucose-induced senescence and dysfunction via the p53 pathway. / 05.11.2020 / PubMed / Full text
Melatonin and Sirtuins in Buccal Epithelium: Potential Biomarkers of Aging and Age-Related Pathologies. / 30.10.2020 / PubMed / Full text
Sirtuins as Possible Predictors of Aging and Alzheimer's Disease Development: Verification in the Hippocampus and Saliva. / 10.2020 / PubMed / Full text
The effect of 12-week resistance exercise training on serum levels of cellular aging process parameters in elderly men. / 11.2020 / PubMed / Full text
Ginsenoside Rg1 protects against Sca-1 HSC/HPC cell aging by regulating the SIRT1-FOXO3 and SIRT3-SOD2 signaling pathways in a γ-ray irradiation-induced aging mice model. / 08.2020 / PubMed / Full text
[i]SIRT3[/i] Transfection of Aged Human Bone Marrow-Derived Mesenchymal Stem Cells Improves Cell Therapy-Mediated Myocardial Repair. / 28.04.2020 / PubMed / Full text
17β-estradiol inhibits H O -induced senescence in HUVEC cells through upregulating SIRT3 expression and promoting autophagy. / 10.2020 / PubMed / Full text
CR6 interacting factor 1 deficiency induces premature senescence via SIRT3 inhibition in endothelial cells. / 04.2020 / PubMed / Full text
[Metabolic Alteration in Aging Process: Metabolic Remodeling in White Adipose Tissue by Caloric Restriction]. / 2020 / PubMed / Full text
Glucose-induced oxidative stress and accelerated aging in endothelial cells are mediated by the depletion of mitochondrial SIRTs. / 02.2020 / PubMed / Full text
Mitochondrial function in skeletal myofibers is controlled by a TRF2-SIRT3 axis over lifetime. / 03.2020 / PubMed / Full text
Context-Dependent Roles for SIRT2 and SIRT3 in Tumor Development Upon Calorie Restriction or High Fat Diet. / 2019 / PubMed / Full text
The yin and yang faces of the mitochondrial deacetylase sirtuin 3 in age-related disorders. / 01.2020 / PubMed / Full text
Inhibition of Mitochondrial Calcium Overload by SIRT3 Prevents Obesity- or Age-Related Whitening of Brown Adipose Tissue. / 02.2020 / PubMed / Full text
Lysine malonylation and propionylation are prevalent in human lens proteins. / 01.2020 / PubMed / Full text
Metabolism and biochemical properties of nicotinamide adenine dinucleotide (NAD) analogs, nicotinamide guanine dinucleotide (NGD) and nicotinamide hypoxanthine dinucleotide (NHD). / 11.09.2019 / PubMed / Full text
[i]Sirt3[/i] Deficiency Shortens Life Span and Impairs Cardiac Mitochondrial Function Rescued by [i]Opa1[/i] Gene Transfer. / 12.2019 / PubMed / Full text
Low-Dose Pesticide Mixture Induces Accelerated Mesenchymal Stem Cell Aging In Vitro. / 08.2019 / PubMed / Full text
NLRP3/IL1β inflammasome associated with the aging bladder triggers bladder dysfunction in female rats. / 04.2019 / PubMed / Full text
Targeted Mitochondrial COQ Delivery Attenuates Antiretroviral-Drug-Induced Senescence of Neural Progenitor Cells. / 04.02.2019 / PubMed / Full text
Caffeine Protects Skin from Oxidative Stress-Induced Senescence through the Activation of Autophagy. / 2018 / PubMed / Full text
The pathophysiological importance and therapeutic potential of NAD' biosynthesis and mitochondrial sirtuin SIRT3 in age-associated diseases. / 09.2016 / PubMed
Aging-Related Overactivity of the Angiotensin/AT1 Axis Decreases Sirtuin 3 Levels in the Substantia Nigra, Which Induces Vulnerability to Oxidative Stress and Neurodegeneration. / 14.02.2020 / PubMed / Full text
6-gingerol ameliorates age-related hepatic steatosis: Association with regulating lipogenesis, fatty acid oxidation, oxidative stress and mitochondrial dysfunction. / 01.01.2019 / PubMed / Full text
Sirtuins and NAD in the Development and Treatment of Metabolic and Cardiovascular Diseases. / 14.09.2018 / PubMed / Full text
Moderate calorie restriction attenuates age‑associated alterations and improves cardiac function by increasing SIRT1 and SIRT3 expression. / 10.2018 / PubMed / Full text
Melatonin Mitigates Mitochondrial Meltdown: Interactions with SIRT3. / 18.08.2018 / PubMed / Full text
Master athletes have higher miR-7, SIRT3 and SOD2 expression in skeletal muscle than age-matched sedentary controls. / 10.2018 / PubMed / Full text
Sirtuin3 protects aged human mesenchymal stem cells against oxidative stress and enhances efficacy of cell therapy for ischaemic heart diseases. / 11.2018 / PubMed / Full text
Sirtuins in Renal Health and Disease. / 07.2018 / PubMed / Full text
Enhanced longevity and metabolism by brown adipose tissue with disruption of the regulator of G protein signaling 14. / 08.2018 / PubMed / Full text
Physical Exercise Improves Aging-Related Changes in Angiotensin, IGF-1, SIRT1, SIRT3, and VEGF in the Substantia Nigra. / 10.11.2018 / PubMed / Full text
Differential gene expression of sirtuins between somatotropinomas and nonfunctioning pituitary adenomas. / 08.2018 / PubMed / Full text
NAD supplementation normalizes key Alzheimer's features and DNA damage responses in a new AD mouse model with introduced DNA repair deficiency. / 20.02.2018 / PubMed / Full text
Metformin regulates mitochondrial biogenesis and senescence through AMPK mediated H3K79 methylation: Relevance in age-associated vascular dysfunction. / 04.2018 / PubMed / Full text
Salidroside attenuates endothelial cellular senescence via decreasing the expression of inflammatory cytokines and increasing the expression of SIRT3. / 10.2018 / PubMed / Full text
Role of Beta-adrenergic Receptors and Sirtuin Signaling in the Heart During Aging, Heart Failure, and Adaptation to Stress. / 01.2018 / PubMed / Full text
[Protective effect of total saponins of Panax notoginseng combined with total flavonoids of epimedium on D-galactose-incuced senescence of H9c2 cell]. / 02.2017 / PubMed / Full text
Obesity and aging diminish sirtuin 1 (SIRT1)-mediated deacetylation of SIRT3, leading to hyperacetylation and decreased activity and stability of SIRT3. / 20.10.2017 / PubMed / Full text
miR-34a and miR-9 are overexpressed and SIRT genes are downregulated in peripheral blood mononuclear cells of aging humans. / 08.2017 / PubMed / Full text
EphB2 signaling-mediated Sirt3 expression reduces MSC senescence by maintaining mitochondrial ROS homeostasis. / 09.2017 / PubMed / Full text
Upregulation of mitochondrial NAD levels impairs the clonogenicity of SSEA1 glioblastoma tumor-initiating cells. / 09.06.2017 / PubMed / Full text
Identification of tissue-specific transcriptional markers of caloric restriction in the mouse and their use to evaluate caloric restriction mimetics. / 08.2017 / PubMed / Full text
Longevity and healthy ageing genes FOXO3A and SIRT3: Serum protein marker and new road map to burst oxidative stress by Withania somnifera. / 09.2017 / PubMed / Full text
Sirtuin 7 is decreased in pulmonary fibrosis and regulates the fibrotic phenotype of lung fibroblasts. / 01.06.2017 / PubMed / Full text
Mitochondrial Sirtuins and Molecular Mechanisms of Aging. / 04.2017 / PubMed / Full text
Melatonin and sirtuins: A "not-so unexpected" relationship. / 03.2017 / PubMed / Full text
SIRT3 mediates decrease of oxidative damage and prevention of ageing in porcine fetal fibroblasts. / 15.05.2017 / PubMed / Full text
The Role of Mitochondrial Non-Enzymatic Protein Acylation in Ageing. / 2016 / PubMed / Full text
Melatonin improves age-induced fertility decline and attenuates ovarian mitochondrial oxidative stress in mice. / 12.10.2016 / PubMed / Full text
Gardenia jasminoides extract-capped gold nanoparticles reverse hydrogen peroxide-induced premature senescence. / 11.2016 / PubMed / Full text
Function of the SIRT3 mitochondrial deacetylase in cellular physiology, cancer, and neurodegenerative disease. / 02.2017 / PubMed / Full text
Sirtuin 3 Deregulation Promotes Pulmonary Fibrosis. / 01.05.2017 / PubMed / Full text
Effects of Grape Skin Extract on Age-Related Mitochondrial Dysfunction, Memory and Life Span in C57BL/6J Mice. / 09.2016 / PubMed / Full text
Restoration of Mitochondrial NAD Levels Delays Stem Cell Senescence and Facilitates Reprogramming of Aged Somatic Cells. / 12.2016 / PubMed / Full text
Mitochondrial Sirtuin 3 and Renal Diseases. / 2016 / PubMed / Full text
CD38 Dictates Age-Related NAD Decline and Mitochondrial Dysfunction through an SIRT3-Dependent Mechanism. / 14.06.2016 / PubMed / Full text
The role of mitochondrial sirtuins in health and disease. / 11.2016 / PubMed / Full text
Effects of intrinsic aerobic capacity, aging and voluntary running on skeletal muscle sirtuins and heat shock proteins. / 15.06.2016 / PubMed / Full text
Manganese Superoxide Dismutase Acetylation and Dysregulation, Due to Loss of SIRT3 Activity, Promote a Luminal B-Like Breast Carcinogenic-Permissive Phenotype. / 20.08.2016 / PubMed / Full text
Sirtuins, Cell Senescence, and Vascular Aging. / 05.2016 / PubMed / Full text
SIRT3 Blocks Aging-Associated Tissue Fibrosis in Mice by Deacetylating and Activating Glycogen Synthase Kinase 3β. / 14.12.2015 / PubMed / Full text
The expression levels of the sirtuins in patients with BCC. / 05.2016 / PubMed / Full text
Effects of Aging and Cardiovascular Disease Risk Factors on the Expression of Sirtuins in the Human Corpus Cavernosum. / 11.2015 / PubMed / Full text
Localization of sirtuins (SIRT1-7) in the aged mouse inner ear. / 2016 / PubMed / Full text
Are sirtuins markers of ovarian aging? / 10.01.2016 / PubMed / Full text
The Role of Mitochondrial DNA in Mediating Alveolar Epithelial Cell Apoptosis and Pulmonary Fibrosis. / 07.09.2015 / PubMed / Full text
Sirtuin-dependent clock control: new advances in metabolism, aging and cancer. / 11.2015 / PubMed / Full text
Mitochondrial Aging and Physical Decline: Insights From Three Generations of Women. / 11.2015 / PubMed / Full text
Cyclic AMP Mimics the Anti-ageing Effects of Calorie Restriction by Up-Regulating Sirtuin. / 08.07.2015 / PubMed / Full text
SIRT3 regulates progression and development of diseases of aging. / 09.2015 / PubMed / Full text
Sirtuin Functions in Female Fertility: Possible Role in Oxidative Stress and Aging. / 2015 / PubMed / Full text
Differential expression of sirtuins in the aging rat brain. / 2015 / PubMed / Full text
A conserved transcriptional signature of delayed aging and reduced disease vulnerability is partially mediated by SIRT3. / 2015 / PubMed / Full text
Expression of SIRT1 and SIRT3 varies according to age in mice. / 03.2015 / PubMed / Full text
Practicality of intermittent fasting in humans and its effect on oxidative stress and genes related to aging and metabolism. / 04.2015 / PubMed / Full text
Differential Effect of Endurance Training on Mitochondrial Protein Damage, Degradation, and Acetylation in the Context of Aging. / 11.2015 / PubMed / Full text
Decreased SIRT3 in aged human mesenchymal stromal/stem cells increases cellular susceptibility to oxidative stress. / 11.2014 / PubMed / Full text
Sirtuins: guardians of mammalian healthspan. / 07.2014 / PubMed / Full text
SIRT3 deficiency exacerbates ischemia-reperfusion injury: implication for aged hearts. / 15.06.2014 / PubMed / Full text
Regulation of Akt signaling by sirtuins: its implication in cardiac hypertrophy and aging. / 17.01.2014 / PubMed / Full text
Partial reversal of skeletal muscle aging by restoration of normal NAD⁺ levels. / 02.2014 / PubMed / Full text
[Protective effects of caloric restriction on ovarian function]. / 10.2013 / PubMed
SIRT3: as simple as it seems? / 2014 / PubMed / Full text
Ubiquinol-10 supplementation activates mitochondria functions to decelerate senescence in senescence-accelerated mice. / 01.06.2014 / PubMed / Full text
Forever young: SIRT3 a shield against mitochondrial meltdown, aging, and neurodegeneration. / 06.09.2013 / PubMed / Full text
Mitochondrial sirtuins as therapeutic targets for age-related disorders. / 03.2013 / PubMed / Full text
Dietary restriction increases protein acetylation in the livers of aged rats. / 2013 / PubMed / Full text
Transcriptional and phenotypic changes in aorta and aortic valve with aging and MnSOD deficiency in mice. / 15.11.2013 / PubMed / Full text
Nicotinamide phosphoribosyltransferase is required for the calorie restriction-mediated improvements in oxidative stress, mitochondrial biogenesis, and metabolic adaptation. / 01.2014 / PubMed / Full text
Sirtuins: from metabolic regulation to brain aging. / 2013 / PubMed / Full text
Modulation of human longevity by SIRT3 single nucleotide polymorphisms in the prospective study "Treviso Longeva (TRELONG)". / 02.2014 / PubMed / Full text
SIRT3 deacetylates FOXO3 to protect mitochondria against oxidative damage. / 10.2013 / PubMed / Full text
Do sirtuins promote mammalian longevity? A critical review on its relevance to the longevity effect induced by calorie restriction. / 06.2013 / PubMed / Full text
SIRT3 overexpression antagonizes high glucose accelerated cellular senescence in human diploid fibroblasts via the SIRT3-FOXO1 signaling pathway. / 12.2013 / PubMed / Full text

SOD2Править

Astaxanthin Counteracts Vascular Calcification In Vitro Through an Early Up-Regulation of SOD2 Based on a Transcriptomic Approach. / 12.11.2020 / PubMed / Full text
Alginate Oligosaccharide Prevents against D-galactose-mediated Cataract in C57BL/6J Mice via Regulating Oxidative Stress and Antioxidant System. / 06.11.2020 / PubMed / Full text
Epigenetic regulation of miR-29a/miR-30c/DNMT3A axis controls SOD2 and mitochondrial oxidative stress in human mesenchymal stem cells. / 09.09.2020 / PubMed / Full text
Protoflavones in melanoma therapy: Prooxidant and pro-senescence effect of protoapigenone and its synthetic alkyl derivative in A375 cells. / 01.11.2020 / PubMed / Full text
The antioxidant icariin protects porcine oocytes from age-related damage in vitro. / 12.05.2020 / PubMed / Full text
Ginsenoside Rg1 protects against Sca-1 HSC/HPC cell aging by regulating the SIRT1-FOXO3 and SIRT3-SOD2 signaling pathways in a γ-ray irradiation-induced aging mice model. / 08.2020 / PubMed / Full text
Almond Skin Extracts and Chlorogenic Acid Delay Chronological Aging and Enhanced Oxidative Stress Response in Yeast. / 28.05.2020 / PubMed / Full text
Brazilian berry extract (Myrciaria jaboticaba): A promising therapy to minimize prostatic inflammation and oxidative stress. / 08.2020 / PubMed / Full text
Opposing p53 and mTOR/AKT promote an in vivo switch from apoptosis to senescence upon telomere shortening in zebrafish. / 19.05.2020 / PubMed / Full text
Aging alters acetylation status in skeletal and cardiac muscles. / 06.2020 / PubMed / Full text
Doxorubicin-induced normal breast epithelial cellular aging and its related breast cancer growth through mitochondrial autophagy and oxidative stress mitigated by ginsenoside Rh2. / 07.2020 / PubMed / Full text
Bioactive peptides derived from crimson snapper and in vivo anti-aging effects on fat diet-induced high fat Drosophila melanogaster. / 29.01.2020 / PubMed / Full text
Ellagic acid prolongs the lifespan of Drosophila melanogaster. / 02.2020 / PubMed / Full text
Active vitamin D supplementation alleviates initiation and progression of nonalcoholic fatty liver disease by repressing the p53 pathway. / 15.01.2020 / PubMed / Full text
Chlorella vulgaris modulates the expression of senescence-associated genes in replicative senescence of human diploid fibroblasts. / 01.2020 / PubMed / Full text
Age-Associated Changes in Antioxidants and Redox Proteins of Rat Heart. / 30.12.2019 / PubMed / Full text
Impact of curcumin on replicative and chronological aging in the Saccharomyces cerevisiae yeast. / 02.2020 / PubMed / Full text
CD38 Deficiency Alleviates D-Galactose-Induced Myocardial Cell Senescence Through NAD /Sirt1 Signaling Pathway. / 2019 / PubMed / Full text
MicroRNA-34a (miR-34a) Mediates Retinal Endothelial Cell Premature Senescence through Mitochondrial Dysfunction and Loss of Antioxidant Activities. / 22.08.2019 / PubMed / Full text
Age-Dependent Oxidative Stress Elevates Arginase 1 and Uncoupled Nitric Oxide Synthesis in Skeletal Muscle of Aged Mice. / 2019 / PubMed / Full text
Age-Related Oxidative Changes in Primary Porcine Fibroblasts Expressing Mutated Huntingtin. / 2019 / PubMed / Full text
Preventive effect of Lactobacillus plantarum KSFY02 isolated from naturally fermented yogurt from Xinjiang, China, on d-galactose-induced oxidative aging in mice. / 07.2019 / PubMed / Full text
Protective effects of pyrroloquinoline quinine against oxidative stress-induced cellular senescence and inflammation in human renal tubular epithelial cells via Keap1/Nrf2 signaling pathway. / 07.2019 / PubMed / Full text
Sex differences in the aging human heart: decreased sirtuins, pro-inflammatory shift and reduced anti-oxidative defense. / 08.04.2019 / PubMed / Full text
NKT-like cells reveal higher than T lymphocytes expression of cellular protective proteins HSP70 and SOD2 and comparably increased expression of SIRT1 in the oldest seniors. / 2018 / PubMed / Full text
Ku86 alleviates human umbilical vein endothelial cellular apoptosis and senescence induced by a low dose of ionizing radiation. / 02.2019 / PubMed / Full text
Putrescine delays postovulatory aging of mouse oocytes by upregulating PDK4 expression and improving mitochondrial activity. / 16.12.2018 / PubMed / Full text
CD56bright cells respond to stimulation until very advanced age revealing increased expression of cellular protective proteins SIRT1, HSP70 and SOD2. / 2018 / PubMed / Full text
Functional restoration of replicative senescent mesenchymal stem cells by the brown alga [i]Undaria pinnatifida[/i]. / 2017 / PubMed / Full text
[i]Lactobacillus plantarum[/i] CQPC11 Isolated from Sichuan Pickled Cabbages Antagonizes d-galactose-Induced Oxidation and Aging in Mice. / 20.11.2018 / PubMed / Full text
Superoxide dismutase activity is significantly lower in end-stage osteoarthritic cartilage than non-osteoarthritic cartilage. / 2018 / PubMed / Full text
Reactive oxygen species, aging and articular cartilage homeostasis. / 20.02.2019 / PubMed / Full text
Cytokine modulation, oxidative stress and thymic dysfunctions: Role of age-related changes in the experimental Trypanosoma cruzi infection: Age-related thymic dysfunctions and Trypanosoma cruzi infection. / 11.2018 / PubMed / Full text
Mitohormesis in Mice via Sustained Basal Activation of Mitochondrial and Antioxidant Signaling. / 06.11.2018 / PubMed / Full text
Master athletes have higher miR-7, SIRT3 and SOD2 expression in skeletal muscle than age-matched sedentary controls. / 10.2018 / PubMed / Full text
Age-related changes in vascular responses to angiotensin-(1-7) in female mice. / 07-09.2018 / PubMed / Full text
Effect of β-D-Mannuronic Acid (M2000) on Oxidative Stress Enzymes' Gene Using Healthy Donor Peripheral Blood Mononuclear Cells for Evaluating the Anti-Aging Property. / 2019 / PubMed / Full text
The impact of preserved Klotho gene expression on antioxidative stress activity in healthy kidney. / 01.08.2018 / PubMed / Full text
Age-related NMDA signaling alterations in SOD2 deficient mice. / 06.2018 / PubMed / Full text
Inhibition of oxidative stress in cholinergic projection neurons fully rescues aging-associated olfactory circuit degeneration in [i]Drosophila[/i]. / 18.01.2018 / PubMed / Full text
Ultrafine particulate matter exposure impairs vasorelaxant response in superoxide dismutase 2-deficient murine aortic rings. / 2018 / PubMed / Full text
COCOA (Theobroma cacao) Polyphenol-Rich Extract Increases the Chronological Lifespan of Saccharomyces cerevisiae. / 2016 / PubMed
Yeast polyubiquitin gene UBI4 deficiency leads to early induction of apoptosis and shortened replicative lifespan. / 07.2018 / PubMed / Full text
Time-response characteristic and potential biomarker identification of heavy metal induced toxicity in zebrafish. / 01.2018 / PubMed / Full text
Dietary supplementation with acetyl-l-carnitine counteracts age-related alterations of mitochondrial biogenesis, dynamics and antioxidant defenses in brain of old rats. / 11.2017 / PubMed / Full text
Aerobic exercise prevents rarefaction of pial collaterals and increased stroke severity that occur with aging. / 11.2017 / PubMed / Full text
Betaine promotes cell differentiation of human osteoblasts in primary culture. / 07.06.2017 / PubMed / Full text
Vulnerability of white matter tracts and cognition to the SOD2 polymorphism: A preliminary study of antioxidant defense genes in brain aging. / 30.06.2017 / PubMed / Full text
Age-related reduction in the expression of FOXO transcription factors and correlations with intervertebral disc degeneration. / 12.2017 / PubMed / Full text
Ionizing radiation induces long-term senescence in endothelial cells through mitochondrial respiratory complex II dysfunction and superoxide generation. / 07.2017 / PubMed / Full text
An in vitro evaluation of anti-aging effect of guluronic acid (G2013) based on enzymatic oxidative stress gene expression using healthy individuals PBMCs. / 06.2017 / PubMed / Full text
The In Vitro Influence of a Genetic Superoxide-Hydrogen Peroxide Imbalance on Immunosenescence. / 08.2017 / PubMed / Full text
Anti-aging effects of M2000 (β-D-mannuronic acid) as a novel immunosuppressive drug on the enzymatic and non-enzymatic oxidative stress parameters in an experimental model. / 01.05.2017 / PubMed / Full text
Expression of cellular protective proteins SIRT1, HSP70 and SOD2 correlates with age and is significantly higher in NK cells of the oldest seniors. / 2017 / PubMed / Full text
SIRT3 mediates decrease of oxidative damage and prevention of ageing in porcine fetal fibroblasts. / 15.05.2017 / PubMed / Full text
Loss of BOSS Causes Shortened Lifespan with Mitochondrial Dysfunction in Drosophila. / 2017 / PubMed / Full text
Altered S-nitrosylation of p53 is responsible for impaired antioxidant response in skeletal muscle during aging. / 20.12.2016 / PubMed / Full text
Protective Effects of Hydrogen Sulfide in the Ageing Kidney. / 2016 / PubMed / Full text
Protective effects and mechanisms investigation of Kuntai capsule on the ovarian function of a novel model with accelerated aging ovaries. / 04.01.2017 / PubMed / Full text
Response of BAX, Bcl-2 Proteins, and SIRT1/PGC-1α mRNA Expression to 8-Week Treadmill Running in the Aging Rat Skeletal Muscle. / 2016 / PubMed / Full text
Sirtuin 3 Deregulation Promotes Pulmonary Fibrosis. / 01.05.2017 / PubMed / Full text
Blackberry, raspberry and black raspberry polyphenol extracts attenuate angiotensin II-induced senescence in vascular smooth muscle cells. / 12.10.2016 / PubMed / Full text
Purple sweet potato anthocyanin attenuates fat-induced mortality in Drosophila melanogaster. / 09.2016 / PubMed / Full text
Age-Associated Changes in the Vascular Renin-Angiotensin System in Mice. / 2016 / PubMed / Full text
Evidence that oxidative stress is higher in replacement gilts than in multiparous sows. / 10.2016 / PubMed / Full text
Age-dependent changes of the antioxidant system in rat livers are accompanied by altered MAPK activation and a decline in motor signaling. / 2015 / PubMed / Full text
Aging Promotes Sirtuin 3-Dependent Cartilage Superoxide Dismutase 2 Acetylation and Osteoarthritis. / 08.2016 / PubMed / Full text
Targeting genes in insulin-associated signalling pathway, DNA damage, cell proliferation and cell differentiation pathways by tocotrienol-rich fraction in preventing cellular senescence of human diploid fibroblasts. / 11-12.2015 / PubMed / Full text
The Immp2l mutation causes age-dependent degeneration of cerebellar granule neurons prevented by antioxidant treatment. / 02.2016 / PubMed / Full text
Mitochondrial superoxide dismutase deficiency accelerates chronological aging in the fission yeast Schizosaccharomyces pombe. / 01.2016 / PubMed / Full text
Oral treatment with herbal formula B307 alleviates cardiac failure in aging R6/2 mice with Huntington's disease via suppressing oxidative stress, inflammation, and apoptosis. / 2015 / PubMed / Full text
Cordyceps sinensis oral liquid prolongs the lifespan of the fruit fly, Drosophila melanogaster, by inhibiting oxidative stress. / 10.2015 / PubMed / Full text
Rejuvenation of MPTP-induced human neural precursor cell senescence by activating autophagy. / 21.08.2015 / PubMed / Full text
Effects of a recombinant complement component C3b functional fragment α2MR (α2-macroglobulin receptor) additive on the immune response of juvenile orange-spotted grouper (Epinephelus coioides) after the exposure to cold shock challenge. / 08.2015 / PubMed / Full text
Ameliorative effect of black rice anthocyanin on senescent mice induced by D-galactose. / 11.2014 / PubMed / Full text
Increased production of mitochondrial reactive oxygen species and reduced adult life span in an insecticide-resistant strain of Anopheles gambiae. / 06.2014 / PubMed / Full text
Age-related decrease in the mitochondrial sirtuin deacetylase Sirt3 expression associated with ROS accumulation in the auditory cortex of the mimetic aging rat model. / 2014 / PubMed / Full text
Lifelong training preserves some redox-regulated adaptive responses after an acute exercise stimulus in aged human skeletal muscle. / 05.2014 / PubMed / Full text
Absence of superoxide dismutase activity causes nuclear DNA fragmentation during the aging process. / 07.02.2014 / PubMed / Full text
Contribution of genetic polymorphisms on functional status at very old age: a gene-based analysis of 38 genes (311 SNPs) in the oxidative stress pathway. / 04.2014 / PubMed / Full text
Lifespan extension by cranberry supplementation partially requires SOD2 and is life stage independent. / 02.2014 / PubMed / Full text
Polymorphisms in the superoxidase dismutase genes reveal no association with human longevity in Germans: a case-control association study. / 12.2013 / PubMed / Full text
Aging and calorie restriction oppositely affect mitochondrial biogenesis through TFAM binding at both origins of mitochondrial DNA replication in rat liver. / 2013 / PubMed / Full text
Postprandial oxidative stress is modulated by dietary fat in adipose tissue from elderly people. / 04.2014 / PubMed / Full text
Serum from humans on long-term calorie restriction enhances stress resistance in cell culture. / 08.2013 / PubMed / Full text
Mice with heterozygous deficiency of manganese superoxide dismutase (SOD2) have a skin immune system with features of "inflamm-aging". / 03.2014 / PubMed / Full text
Antiaging effects of astaxanthin-rich alga Haematococcus pluvialis on fruit flies under oxidative stress. / 14.08.2013 / PubMed / Full text
SOD2 in mitochondrial dysfunction and neurodegeneration. / 09.2013 / PubMed / Full text
Blueberry treatment attenuates D-galactose-induced oxidative stress and tissue damage in rat liver. / 04.2014 / PubMed / Full text
A functional and genetic analysis of SOD2 promoter variants and their contribution to age-related hearing loss. / 07-08.2013 / PubMed / Full text
Age-associated molecular changes in the kidney in aged mice. / 2012 / PubMed / Full text
Superoxide dismutase gene polymorphisms in patients with age-related cataract. / 09.2013 / PubMed / Full text
Sesamin extends the mean lifespan of fruit flies. / 04.2013 / PubMed / Full text
Genetic manipulation of longevity-related genes as a tool to regulate yeast life span and metabolite production during winemaking. / 02.01.2013 / PubMed / Full text
Antioxidant enzymes in cerebral cortex of immature rats following experimentally-induced seizures: upregulation of mitochondrial MnSOD (SOD2). / 04.2013 / PubMed / Full text

THПравить

Thyroid hormone signaling is associated with physical performance, muscle mass, and strength in a cohort of oldest-old: results from the Mugello study. / 21.11.2020 / PubMed / Full text
Social Environment Ameliorates Behavioral and Immune Impairments in Tyrosine Hydroxylase Haploinsufficient Female Mice. / 09.08.2020 / PubMed / Full text
Mechanism of thyroid hormone signaling in skeletal muscle of aging mice. / 27.07.2020 / PubMed / Full text
Longitudinal changes in bone mineral density and trabecular bone score in Korean adults: a community-based prospective study. / 03.07.2020 / PubMed / Full text
Age-associated decline in neural, endocrine, and immune responses in men and women: Involvement of intracellular signaling pathways. / 15.08.2020 / PubMed / Full text
Familial Longevity is Associated with an Attenuated Thyroidal Response to Recombinant Human Thyroid Stimulating Hormone. / 01.07.2020 / PubMed / Full text
Quantitative proteomic profiling of the rat substantia nigra places glial fibrillary acidic protein at the hub of proteins dysregulated during aging: Implications for idiopathic Parkinson's disease. / 07.2020 / PubMed / Full text
Microglia senescence occurs in both substantia nigra and ventral tegmental area. / 11.2020 / PubMed / Full text
Withaferin-A Protects the Nigral Dopamine Neuron and Recovers Motor Activity in Aged Rats. / 2019 / PubMed / Full text
Effects of age on feeding response: Focus on the rostral C1 neuron and its glucoregulatory proteins. / 01.2020 / PubMed / Full text
Effects of physical activity on bone mineral density in older adults: Korea National Health and Nutrition Examination Survey, 2008-2011. / 26.10.2019 / PubMed / Full text
GFR-α1 Expression in Substantia Nigra Increases Bilaterally Following Unilateral Striatal GDNF in Aged Rats and Attenuates Nigral Tyrosine Hydroxylase Loss Following 6-OHDA Nigrostriatal Lesion. / 16.10.2019 / PubMed / Full text
Age-Related Resistance to Thyroid Hormone Action. / 11.2019 / PubMed / Full text
Age-Dependent Changes in Glucose Homeostasis in Male Deiodinase Type 2 Knockout Zebrafish. / 01.11.2019 / PubMed / Full text
Age effect on thyroid hormone brain response in male mice. / 12.2019 / PubMed / Full text
Aging Is Associated with Low Thyroid State and Organ-Specific Sensitivity to Thyroxine. / 12.2019 / PubMed / Full text
Age-Associated Dopaminergic Neuron Loss and Midbrain Glia Cell Phenotypic Polarization. / 01.09.2019 / PubMed / Full text
Age-Related Decrease in Tyrosine Hydroxylase Immunoreactivity in the Substantia Nigra and Region-Specific Changes in Microglia Morphology in HIV-1 Tg Rats. / 10.2019 / PubMed / Full text
An experimental model of Braak's pretangle proposal for the origin of Alzheimer's disease: the role of locus coeruleus in early symptom development. / 03.07.2019 / PubMed / Full text
The age modification to leukocyte telomere length effect on bone mineral density and osteoporosis among Chinese elderly women. / 11.2019 / PubMed / Full text
Regeneration of Dopaminergic Neurons in Adult Zebrafish Depends on Immune System Activation and Differs for Distinct Populations. / 12.06.2019 / PubMed / Full text
Oxidative-Inflammatory Stress in Immune Cells from Adult Mice with Premature Aging. / 12.02.2019 / PubMed / Full text
Aging Alters Phenotypic Traits of Thyroid Dysfunction in Male Mice With Divergent Effects on Complex Systems but Preserved Thyroid Hormone Action in Target Organs. / 12.07.2019 / PubMed / Full text
Association of bone mineral density with hemoglobin and change in hemoglobin among older men and women: The Cardiovascular Health Study. / 03.2019 / PubMed / Full text
Applications for non-invasive thyroid hormone measurements in mammalian ecology, growth, and maintenance. / 09.2018 / PubMed / Full text
Tyrosine Hydroxylase Inhibition in Substantia Nigra Decreases Movement Frequency. / 04.2019 / PubMed / Full text
The Association between Daytime Napping Characteristics and Bone Mineral Density in Elderly Thai Women without Osteoporosis. / 03.07.2018 / PubMed / Full text
Inactivation of the E3 Ubiquitin Ligase IDOL Attenuates Diet-Induced Obesity and Metabolic Dysfunction in Mice. / 08.2018 / PubMed / Full text
Pattern of tyrosine hydroxylase expression during aging of mesolimbic pathway of the rat. / 10.2018 / PubMed / Full text
Prolonged increase in ser31 tyrosine hydroxylase phosphorylation in substantia nigra following cessation of chronic methamphetamine. / 07.2018 / PubMed / Full text
Noni (Morinda citrifolia L.) fruit juice delays immunosenescence in the lymphocytes in lymph nodes of old F344 rats. / 05.2018 / PubMed / Full text
Dietary and Endocrine Regulation of Endogenous Hydrogen Sulfide Production: Implications for Longevity. / 01.06.2018 / PubMed / Full text
Neural Stem Cell Grafts Promote Astroglia-Driven Neurorestoration in the Aged Parkinsonian Brain via Wnt/β-Catenin Signaling. / 08.2018 / PubMed / Full text
Phosphorylated α-Synuclein Accumulations and Lewy Body-like Pathology Distributed in Parkinson's Disease-Related Brain Areas of Aged Rhesus Monkeys Treated with MPTP. / 21.05.2018 / PubMed / Full text
Premature aging in behavior and immune functions in tyrosine hydroxylase haploinsufficient female mice. A longitudinal study. / 03.2018 / PubMed / Full text
Sex-specific phenotypes of hyperthyroidism and hypothyroidism in aged mice. / 22.12.2017 / PubMed / Full text
Changes in neurofilament 200 and tyrosine hydroxylase expression in the cardiac innervation of diabetic rats during aging. / 01-02.2018 / PubMed / Full text
Aging-related limit of exercise efficacy on motor decline. / 2017 / PubMed / Full text
Regional Distribution of Longevity Population and Elements in Drinking Water in Jiangjin District, Chongqing City, China. / 08.2018 / PubMed / Full text
Age-dependent association of thyroid function with brain morphology and microstructural organization: evidence from brain imaging. / 01.2018 / PubMed / Full text
The Circadian Clock Gene Bmal1 Controls Thyroid Hormone-Mediated Spectral Identity and Cone Photoreceptor Function. / 17.10.2017 / PubMed / Full text
The Noradrenergic System of Aged GDNF Heterozygous Mice. / 04.2003 / PubMed / Full text
Chronic Silymarin, Quercetin and Naringenin Treatments Increase Monoamines Synthesis and Hippocampal Sirt1 Levels Improving Cognition in Aged Rats. / 03.2018 / PubMed / Full text
Neuroprotective Effects of Intranasal IGF-1 against Neonatal Lipopolysaccharide-Induced Neurobehavioral Deficits and Neuronal Inflammation in the Substantia Nigra and Locus Coeruleus of Juvenile Rats. / 2017 / PubMed / Full text
Dissociation of Striatal Dopamine and Tyrosine Hydroxylase Expression from Aging-Related Motor Decline: Evidence from Calorie Restriction Intervention. / 12.12.2017 / PubMed / Full text
Comparative study of physico-chemical parameters of drinking water from some longevity and non-longevity areas of China. / 06.2017 / PubMed / Full text
Hypothalamic-Pituitary Axis Regulates Hydrogen Sulfide Production. / 06.06.2017 / PubMed / Full text
[Developmental changes of neurotransmitter properties in sympathetic neurons]. / 2016 / PubMed
Citrulline stimulates locomotor activity in aged rats: Implication of the dopaminergic pathway. / 06.2017 / PubMed / Full text
Age-related changes in immunoreactivity for dopamine β-hydroxylase in carotid body glomus cells in spontaneously hypertensive rats. / 07.2017 / PubMed / Full text
Interactions between Kisspeptin Neurons and Hypothalamic Tuberoinfundibular Dopaminergic Neurons in Aged Female Rats. / 28.12.2016 / PubMed / Full text
Noni (Morinda citrifolia L.) fruit juice reverses age-related decline in neural-immune interactions in the spleens of old F344 rats. / 23.02.2017 / PubMed / Full text
Thyroid hormone-stimulated increases in PGC-1α and UCP2 promote life history-specific endocrine changes and maintain a lipid-based metabolism. / 01.02.2017 / PubMed / Full text
Tyrosine hydroxylase haploinsufficiency prevents age-associated arterial pressure elevation and increases half-life in mice. / 01.2017 / PubMed / Full text
Deletion of autophagy-related gene 7 in dopaminergic neurons prevents their loss induced by MPTP. / 17.12.2016 / PubMed / Full text
Nerve growth factor-induced plasticity in medial prefrontal cortex interneurons of aged Wistar rats. / 01.12.2016 / PubMed / Full text
Functional morphology of pituitary -thyroid and -adrenocortical axes in middle-aged male rats treated with Vitex agnus castus essential oil. / 09.2016 / PubMed / Full text
Cognitive Function and the Ageing Process: The Peculiar Role of Mild Thyroid Failure. / 2016 / PubMed / Full text
Exercise intervention increases spontaneous locomotion but fails to attenuate dopaminergic system loss in a progressive MPTP model in aged mice. / 01.09.2016 / PubMed / Full text
Estrogen-induced neuroprotective and anti-inflammatory effects are dependent on the brain areas of middle-aged female rats. / 06.2016 / PubMed / Full text
[CHANGES IN THE PANCREATIC ISLETS AND NERVOUS ELEMENTS IN RATS DURING AGING (AN IMMUNOHISTOCHEMICAL STUDY)]. / 2015 / PubMed
Thyroid Hemiagenesis from Childhood to Adulthood: Review of Literature and Personal Experience. / 03.2016 / PubMed
Thyroid hormone activates Wnt/β-catenin signaling involved in adult epithelial development during intestinal remodeling in Xenopus laevis. / 08.2016 / PubMed / Full text
Tissue-Specific Suppression of Thyroid Hormone Signaling in Various Mouse Models of Aging. / 2016 / PubMed / Full text
[Premature immunosenescence in catecholamines syntesis deficient mice. Effect of social environment]. / 01-02.2017 / PubMed / Full text
Differences in the trajectory of bone mineral density change measured at the total hip and femoral neck between men and women following hip fracture. / 2016 / PubMed / Full text
The Small GTP-Binding Protein Rhes Influences Nigrostriatal-Dependent Motor Behavior During Aging. / 04.2016 / PubMed / Full text
Retrograde Melanopsin Signaling Increases With Age in Retinal Degenerate Mice Lacking Rods and the Majority of Cones. / 01.01.2016 / PubMed / Full text
Exercise-Mediated Increase in Nigral Tyrosine Hydroxylase Is Accompanied by Increased Nigral GFR-α1 and EAAC1 Expression in Aging Rats. / 17.02.2016 / PubMed / Full text
Differences in Mouse Hepatic Thyroid Hormone Transporter Expression with Age and Hyperthyroidism. / 09.2015 / PubMed / Full text
Influence of caffeine on 3,4-methylenedioxymethamphetamine-induced dopaminergic neuron degeneration and neuroinflammation is age-dependent. / 01.2016 / PubMed / Full text
Reduction in NPY-positive neurons and dysregulation of excitability in young senescence-accelerated mouse prone 8 (SAMP8) hippocampus precede the onset of cognitive impairment. / 10.2015 / PubMed / Full text
Familial Longevity Is Associated With Higher TSH Secretion and Strong TSH-fT3 Relationship. / 10.2015 / PubMed / Full text
Human longevity is characterised by high thyroid stimulating hormone secretion without altered energy metabolism. / 19.06.2015 / PubMed / Full text
Circulating sclerostin and dickkopf-1 levels in ossification of the posterior longitudinal ligament of the spine. / 05.2016 / PubMed / Full text
Improving effect of chronic resveratrol treatment on central monoamine synthesis and cognition in aged rats. / 06.2015 / PubMed / Full text
The gender-differentiated antioxidant effects of a lutein-containing supplement in the aqueous humor of patients with senile cataracts. / 12.2014 / PubMed / Full text
Oxidative stress associated with middle aging leads to sympathetic hyperactivity and downregulation of soluble guanylyl cyclase in corpus cavernosum. / 15.11.2014 / PubMed / Full text
Bone turnover markers predict hip bone loss in elderly European men: results of the European Male Ageing Study (EMAS). / 02.2015 / PubMed / Full text
Age-dependent dopaminergic dysfunction following fetal exposure to atrazine in SD rats. / 05.2014 / PubMed / Full text
Loss of MAP function leads to hippocampal synapse loss and deficits in the Morris Water Maze with aging. / 21.05.2014 / PubMed / Full text
The thyroid hormone receptor β induces DNA damage and premature senescence. / 06.01.2014 / PubMed / Full text
Gender-specific pleiotropic bone-muscle relationship in the elderly from a nationwide survey (KNHANES IV). / 03.2014 / PubMed / Full text
Non-motor parkinsonian pathology in aging A53T α-synuclein mice is associated with progressive synucleinopathy and altered enzymatic function. / 02.2014 / PubMed / Full text
Early social instability affects plasma testosterone during adolescence but does not alter reproductive capacity or measures of stress later in life. / 15.08.2013 / PubMed / Full text
Increase in tetrahydrobiopterin concentration with aging in the cerebral cortex of the senescence-accelerated mouse prone 10 strain caused by abnormal regulation of tetrahydrobiopterin biosynthesis. / 10.2013 / PubMed / Full text
Presence of proNGF-sortilin signaling complex in nigral dopamine neurons and its variation in relation to aging, lactacystin and 6-OHDA insults. / 08.07.2013 / PubMed / Full text
Thyroid hormone reverses aging-induced myocardial fatty acid oxidation defects and improves the response to acutely increased afterload. / 2013 / PubMed / Full text
Chronic testosterone propionate supplement could activated the Nrf2-ARE pathway in the brain and ameliorated the behaviors of aged rats. / 01.09.2013 / PubMed / Full text
Thyroid hormone signaling and homeostasis during aging. / 08.2013 / PubMed / Full text
Adiponectin and resistin in relationship with skeletal status in women from the RAC-OST-POL study. / 2012 / PubMed
Males, but not females, lose tyrosine hydroxylase fibers in the medial prefrontal cortex and are impaired on a delayed alternation task during aging. / 15.04.2013 / PubMed / Full text
Nigral GFRα1 infusion in aged rats increases locomotor activity, nigral tyrosine hydroxylase, and dopamine content in synchronicity. / 06.2013 / PubMed / Full text
Relationship between age/gender-induced survival changes and the magnitude of inflammatory activation and organ dysfunction in post-traumatic sepsis. / 2012 / PubMed / Full text
Alterations in local thyroid hormone signaling in the hippocampus of the SAMP8 mouse at younger ages: association with delayed myelination and behavioral abnormalities. / 03.2013 / PubMed / Full text

ATMПравить

SATMF Suppresses the Premature Senescence Phenotype of the ATM Loss-of-Function Mutant and Improves Its Fertility in [i]Arabidopsis[/i]. / 30.10.2020 / PubMed / Full text
ATM inhibition synergizes with fenofibrate in high grade serous ovarian cancer cells. / 09.2020 / PubMed / Full text
ATM mediated-p53 signaling pathway forms a novel axis for senescence control. / 11.2020 / PubMed / Full text
Senescence Induction by Combined Ionizing Radiation and DNA Damage Response Inhibitors in Head and Neck Squamous Cell Carcinoma Cells. / 01.09.2020 / PubMed / Full text
Non-canonical ATM/MRN activities temporally define the senescence secretory program. / 05.10.2020 / PubMed / Full text
ATM-deficient neural precursors develop senescence phenotype with disturbances in autophagy. / 09.2020 / PubMed / Full text
ATM is a key driver of NF-κB-dependent DNA-damage-induced senescence, stem cell dysfunction and aging. / 22.03.2020 / PubMed / Full text
ATM suppresses leaf senescence triggered by DNA double-strand break through epigenetic control of senescence-associated genes in Arabidopsis. / 07.2020 / PubMed / Full text
Glioblastoma Cells Do Not Affect Axitinib-Dependent Senescence of HUVECs in a Transwell Coculture Model. / 21.02.2020 / PubMed / Full text
Genome-wide Association Analysis in Humans Links Nucleotide Metabolism to Leukocyte Telomere Length. / 05.03.2020 / PubMed / Full text
Declining BRCA-Mediated DNA Repair in Sperm Aging and its Prevention by Sphingosine-1-Phosphate. / 03.2020 / PubMed / Full text
BRCA-related ATM-mediated DNA double-strand break repair and ovarian aging. / 01.01.2020 / PubMed / Full text
ATM Deficiency Accelerates DNA Damage, Telomere Erosion, and Premature T Cell Aging in HIV-Infected Individuals on Antiretroviral Therapy. / 2019 / PubMed / Full text
NF-κB signaling in skin aging. / 12.2019 / PubMed / Full text
SMG1 heterozygosity exacerbates haematopoietic cancer development in Atm null mice by increasing persistent DNA damage and oxidative stress. / 12.2019 / PubMed / Full text
LncRNA RP11-670E13.6, interacted with hnRNPH, delays cellular senescence by sponging microRNA-663a in UVB damaged dermal fibroblasts. / 23.08.2019 / PubMed / Full text
Phosphoproteomic analysis reveals plant DNA damage signalling pathways with a functional role for histone H2AX phosphorylation in plant growth under genotoxic stress. / 12.2019 / PubMed / Full text
Tel1/ATM Signaling to the Checkpoint Contributes to Replicative Senescence in the Absence of Telomerase. / 10.2019 / PubMed / Full text
Curcumin induces multiple signaling pathways leading to vascular smooth muscle cell senescence. / 12.2019 / PubMed / Full text
Long-term culture of mesenchymal stem cells impairs ATM-dependent recognition of DNA breaks and increases genetic instability. / 29.07.2019 / PubMed / Full text
Genetic background, epigenetic factors and dietary interventions which influence human longevity. / 10.2019 / PubMed / Full text
Repair-independent functions of DNA-PKcs protect irradiated cells from mitotic slippage and accelerated senescence. / 01.07.2019 / PubMed / Full text
Meeting report of the 14th Japan-Korea joint symposium on cancer and aging research: current status of translational research and approaches to precision medicine. / 05.2019 / PubMed / Full text
Mechanistic link between DNA damage sensing, repairing and signaling factors and immune signaling. / 2019 / PubMed / Full text
Alleviation of Senescence via ATM Inhibition in Accelerated Aging Models. / 31.03.2019 / PubMed / Full text
Sirt3 mediates the protective effect of hydrogen in inhibiting ROS-induced retinal senescence. / 01.05.2019 / PubMed / Full text
Genomic insult oriented mitochondrial instability and proliferative hindrance in the bone marrow of aplastic mice including stem/progenitor population. / 04.2019 / PubMed / Full text
N-Myc promotes therapeutic resistance development of neuroendocrine prostate cancer by differentially regulating miR-421/ATM pathway. / 18.01.2019 / PubMed / Full text
Hydrogen Indirectly Suppresses Increases in Hydrogen Peroxide in Cytoplasmic Hydroxyl Radical-Induced Cells and Suppresses Cellular Senescence. / 21.01.2019 / PubMed / Full text
Low dose dinaciclib enhances doxorubicin-induced senescence in myeloma RPMI8226 cells by transformation of the p21 and p16 pathways. / 11.2018 / PubMed / Full text
The activated DNA double-strand break repair pathway in cumulus cells from aging patients may be used as a convincing predictor of poor outcomes after in vitro fertilization-embryo transfer treatment. / 2018 / PubMed / Full text
Epigallocatechin-3-gallate and BIX-01294 have different impact on epigenetics and senescence modulation in acute and chronic myeloid leukemia cells. / 05.11.2018 / PubMed / Full text
The SCF ubiquitin ligase complex mediates degradation of the tumor suppressor FBXO31 and thereby prevents premature cellular senescence. / 19.10.2018 / PubMed / Full text
Defenses against Pro-oxidant Forces - Maintenance of Cellular and Genomic Integrity and Longevity. / 10.2018 / PubMed / Full text
The ING1a model of rapid cell senescence. / 01.2019 / PubMed / Full text
Human electronegative LDL induces mitochondrial dysfunction and premature senescence of vascular cells in vivo. / 08.2018 / PubMed / Full text
Boosting ATM activity alleviates aging and extends lifespan in a mouse model of progeria. / 02.05.2018 / PubMed / Full text
Inflammation, a significant player of Ataxia-Telangiectasia pathogenesis? / 07.2018 / PubMed / Full text
Transcriptional Repression of High-Mobility Group Box 2 by p21 in Radiation-Induced Senescence. / 30.04.2018 / PubMed / Full text
Senescence-messaging secretome factors trigger premature senescence in human endometrium-derived stem cells. / 19.02.2018 / PubMed / Full text
Bisphenol A induces DSB-ATM-p53 signaling leading to cell cycle arrest, senescence, autophagy, stress response, and estrogen release in human fetal lung fibroblasts. / 04.2018 / PubMed / Full text
Global mapping of transcription factor motifs in human aging. / 2018 / PubMed / Full text
Ataxia-Telangiectasia Mutated Modulation of Carbon Metabolism in Cancer. / 2017 / PubMed / Full text
DNA damage, metabolism and aging in pro-inflammatory T cells: Rheumatoid arthritis as a model system. / 05.2018 / PubMed / Full text
Genetic interrogation of replicative senescence uncovers a dual role for USP28 in coordinating the p53 and GATA4 branches of the senescence program. / 01.10.2017 / PubMed / Full text
A lowered 26S proteasome activity correlates with mantle lymphoma cell lines resistance to genotoxic stress. / 10.08.2017 / PubMed / Full text
Haplodeficiency of Ataxia Telangiectasia Mutated Accelerates Heart Failure After Myocardial Infarction. / 19.07.2017 / PubMed / Full text
iTRAQ-based proteomic profiling of granulosa cells from lamb and ewe after superstimulation. / 01.10.2017 / PubMed / Full text
[The Role of DNA Double-strain Damage Repairing Mechanisms in Diabetic Atheroscolersis]. / 03.2017 / PubMed
The DNA Damage Response in Neurons: Die by Apoptosis or Survive in a Senescence-Like State? / 2017 / PubMed / Full text
Chemical screening identifies ATM as a target for alleviating senescence. / 06.2017 / PubMed / Full text
Age and Adaptation: Stronger Decision Updating about Real World Risks in Older Age. / 09.2017 / PubMed / Full text
Accumulation of spontaneous γH2AX foci in long-term cultured mesenchymal stromal cells. / 11.12.2016 / PubMed / Full text
Calcium alterations signal either to senescence or to autophagy induction in stem cells upon oxidative stress. / 08.12.2016 / PubMed / Full text
Rats with a missense mutation in Atm display neuroinflammation and neurodegeneration subsequent to accumulation of cytosolic DNA following unrepaired DNA damage. / 04.2017 / PubMed / Full text
ATM-ROS-iNOS axis regulates nitric oxide mediated cellular senescence. / 01.2017 / PubMed / Full text
NAD Replenishment Improves Lifespan and Healthspan in Ataxia Telangiectasia Models via Mitophagy and DNA Repair. / 11.10.2016 / PubMed / Full text
Overcoming ATM Deficiency by Activating the NAD /SIRT1 Axis. / 11.10.2016 / PubMed / Full text
Perturbed hematopoiesis in mice lacking ATMIN. / 20.10.2016 / PubMed / Full text
BRCA-1 Gene Expression and Comparative Proteomic Profile of Primordial Follicles from Young and Adult Buffalo (Bubalus bubalis) Ovaries. / 03.04.2017 / PubMed / Full text
IFI16, an amplifier of DNA-damage response: Role in cellular senescence and aging-associated inflammatory diseases. / 07.2016 / PubMed / Full text
Transcription factor Sp1 prevents TRF2(ΔBΔM)-induced premature senescence in human diploid fibroblasts. / 03.2016 / PubMed / Full text
Mitochondria are required for pro-ageing features of the senescent phenotype. / 01.04.2016 / PubMed / Full text
Induction of DNA double-strand breaks and cellular senescence by human respiratory syncytial virus. / 18.05.2016 / PubMed / Full text
A gain-of-function senescence bypass screen identifies the homeobox transcription factor DLX2 as a regulator of ATM-p53 signaling. / 01.02.2016 / PubMed / Full text
Tetraploidization or autophagy: The ultimate fate of senescent human endometrial stem cells under ATM or p53 inhibition. / 2016 / PubMed / Full text
Health risks for ataxia-telangiectasia mutated heterozygotes: a systematic review, meta-analysis and evidence-based guideline. / 08.2016 / PubMed / Full text
The DNA damage response induces inflammation and senescence by inhibiting autophagy of GATA4. / 25.09.2015 / PubMed / Full text
BRCA Mutations, DNA Repair Deficiency, and Ovarian Aging. / 09.2015 / PubMed / Full text
[Advances of Research on Ataxia Telangiectasia Mutated Gene and Risk Factors of Cardiovascular Disease]. / 04.2015 / PubMed
Requirement of ATR for maintenance of intestinal stem cells in aging Drosophila. / 05.2015 / PubMed / Full text
Temporally distinct roles of ATM and ROS in genotoxic-stress-dependent induction and maintenance of cellular senescence. / 15.01.2015 / PubMed / Full text
Selenoprotein H suppresses cellular senescence through genome maintenance and redox regulation. / 05.12.2014 / PubMed / Full text
A switch-like dynamic mechanism for the initiation of replicative senescence. / 28.11.2014 / PubMed / Full text
Autophagy inhibition switches low-dose camptothecin-induced premature senescence to apoptosis in human colorectal cancer cells. / 01.08.2014 / PubMed / Full text
Fullerenol protects retinal pigment epithelial cells from oxidative stress-induced premature senescence via activating SIRT1. / 20.05.2014 / PubMed / Full text
Essential role for the TRF2 telomere protein in adult skin homeostasis. / 08.2014 / PubMed / Full text
Wild-type p53-induced phosphatase 1 (Wip1) forestalls cellular premature senescence at physiological oxygen levels by regulating DNA damage response signaling during DNA replication. / 2014 / PubMed / Full text
Molecular characterization of collaborator of ARF (CARF) as a DNA damage response and cell cycle checkpoint regulatory protein. / 01.04.2014 / PubMed / Full text
The thyroid hormone receptor β induces DNA damage and premature senescence. / 06.01.2014 / PubMed / Full text
Novel delivery system for T-oligo using a nanocomplex formed with an alpha helical peptide for melanoma therapy. / 2014 / PubMed / Full text
Dysfunction of endothelial progenitor cells from smokers and chronic obstructive pulmonary disease patients due to increased DNA damage and senescence. / 12.2013 / PubMed / Full text
Maternal embryonic leucine zipper kinase (MELK) reduces replication stress in glioblastoma cells. / 16.08.2013 / PubMed / Full text
Epigenetic silencing mediates mitochondria stress-induced longevity. / 04.06.2013 / PubMed / Full text
Changes in splicing factor expression are associated with advancing age in man. / 09.2013 / PubMed / Full text
The role of ATM and DNA damage in neurons: upstream and downstream connections. / 08.2013 / PubMed / Full text
Atrx deficiency induces telomere dysfunction, endocrine defects, and reduced life span. / 05.2013 / PubMed / Full text
Aβ-induced senescent retinal pigment epithelial cells create a proinflammatory microenvironment in AMD. / 01.05.2013 / PubMed / Full text
The ATM signaling network in development and disease. / 2013 / PubMed / Full text
The innate immune response transcription factor relish is necessary for neurodegeneration in a Drosophila model of ataxia-telangiectasia. / 05.2013 / PubMed / Full text
Impairment of BRCA1-related DNA double-strand break repair leads to ovarian aging in mice and humans. / 13.02.2013 / PubMed / Full text