HLA-DQB1
HLA class II histocompatibility antigen, DQ beta 1 chain precursor (MHC class II antigen DQB1) [HLA-DQB]
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Healthy longevity has been an unremitting pursuit of human, but its genetic and the environment causes are still unclear. As longevity population is a good healthy aging model for understanding how the body begin aging and the process of aging, and plasma lipids metabolism and balance is a very important to life maintain and physiologic functional turnover. It is important to explore how the effect of genetic variants associated long-life individuals on lipids metabolism and balance. Therefore, we developed a comparative study based population which contains 2816 longevity and 2819 control. Through whole-exome sequencing and sanger sequencing genotypes, we identified four new single nucleotide polymorphisms of HLA-DQB1(major histocompatibility complex, class II, DQ beta 1), rs41542812 rs1049107 rs1049100 rs3891176([i]P [/i]=0.048-2.811×10 for allele frequencies), associated with longevity in Chinese Longevity Cohort. Further, by analysis of the longevity-variants linked to blood lipids, we identified HLA-DQB1 rs1049107, T-carriers ([i]P [/i]=0.006, OR: 11.277; [i]P [/i]=9.095×10 , OR: 0.025; [i]P [/i]=0.047, OR: 1.901) and HLA-DQB1 rs1049100, T-carriers ([i]P [/i]=1.799×10-6, OR: 0.028) associated with lipid homeostasis in long lived individuals. Our finding showed that longevity and lipid homeostasis were associated with HLA-DQB1 and suggested that immune gene variants could act on both new function of maintaining the homeostasis and anti-aging in longevity.
MeSH Terms
- Adult
- Aged, 80 and over
- Asian Continental Ancestry Group
- Case-Control Studies
- Chi-Square Distribution
- China
- Computational Biology
- Cross-Sectional Studies
- Databases, Genetic
- Female
- Gene Frequency
- Genetic Association Studies
- HLA-DQ beta-Chains
- Haplotypes
- Health Status
- Homeostasis
- Humans
- Lipid Metabolism
- Lipids
- Longevity
- Male
- Middle Aged
- Odds Ratio
- Phenotype
- Polymorphism, Single Nucleotide
Keywords
- Chinese population
- HLA-DQB1
- human longevity
- lipid phenotypes
In Moscow region long-livers we have studied distribution of LPL, CETP, APOE, F2, F5, F7, F13, FGB, ITGA2, ITGB3, PAI-1, MTHFR, MTRR, HLA-DRB1, HLA-DQA1, HLA-DQB1 genes polymorphisms, associated with predisposition to age pathology. Long-livers are characterized by favorable course of cardiovascular diseases accompanied by certain genetic factors. We have established that genotype H-H- of LPL, allele epsilon2 of APOE, genotype CC of MTHFR (677C > T), genotype TC of ITGB3, genotype GA of FGB, HLA-DRB1*11 positively correlate with longevity.
MeSH Terms
- Aged
- Aged, 80 and over
- Alleles
- Cardiovascular Diseases
- Female
- Gene Frequency
- Genetic Markers
- Genetic Predisposition to Disease
- Genotype
- Humans
- Longevity
- Male
- Moscow
- Polymorphism, Genetic
- Prevalence
- Urban Population