FGB
Fibrinogen beta chain precursor [Contains: Fibrinopeptide B; Fibrinogen beta chain]
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[Clinical and genetic characteristics of long-livers in Moscow region].
In Moscow region long-livers we have studied distribution of LPL, CETP, APOE, F2, F5, F7, F13, FGB, ITGA2, ITGB3, PAI-1, MTHFR, MTRR, HLA-DRB1, HLA-DQA1, HLA-DQB1 genes polymorphisms, associated with predisposition to age pathology. Long-livers are characterized by favorable course of cardiovascular diseases accompanied by certain genetic factors. We have established that genotype H-H- of LPL, allele epsilon2 of APOE, genotype CC of MTHFR (677C > T), genotype TC of ITGB3, genotype GA of FGB, HLA-DRB1*11 positively correlate with longevity.
MeSH Terms
- Aged
- Aged, 80 and over
- Alleles
- Cardiovascular Diseases
- Female
- Gene Frequency
- Genetic Markers
- Genetic Predisposition to Disease
- Genotype
- Humans
- Longevity
- Male
- Moscow
- Polymorphism, Genetic
- Prevalence
- Urban Population