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...Fs and Hsps in skeletal muscle. We studied the protein levels of sirtuins (SIRT1, [[SIRT2]], [[SIRT3]], [[SIRT4]], [[SIRT5]], [[SIRT6]] and SIRT7), [[HSF1]] ...

...abolism. EGCG significantly increased the protein expression of [[FOXO1]], Sirt1, [[CAT]], [[FABP1]], [[GSTA2]], [[ACSL1]] and [[CPT2]] but significantly de ...ere and telomerase, PPAR-α, GLUTs, [[FOXO1]], caspase-3, bcl-2, along with SIRT1/AMPK, PI3K/Akt, NF-κB, and insulin/insulin-like growth factor-1 pathways a ...

...s, Cyclin A2, Cyclin D1, [[CDK2]], [[CDK6]], [[ETS1]], [[NBN]], [[RB1]], [[SIRT1]], were down-regulated. The increase in cyclin-dependent kinase inhibitors ...

...s with SEN sEVs induced a miR-21/miR-217-related impairment of [[DNMT1]]-[[SIRT1]] expression, the reduction of proliferation markers, the acquisition of a * SIRT1 ...

...[[FEN1]], [[DNA2]], RecQ helicases, Top2α, Top2β, [[TOP3A]], DNMT1/3a/3b, SIRT1). In addition, specialized telomeric proteins, such as [[TERT]] (telomerase ...

...[[FGFR4]] signaling-activated PDAC cells. Furthermore, downregulation of [[SIRT1]] and [[SIRT6]] by BLU9931 contributed to senescence induction, priming the ...

...binding, ERK 1/2 activation, IL-8 release and mRNA levels but decreased [[SIRT1]], [[HDAC2]], [[HDAC3]] and FoxO3 nuclear expression. Combined therapy with ...

...erine-threonine kinase(Akt)/mTOR,the AMPK/silent information regulation 1 (Sirt1) and transforming growth factor β (TGF-β) play the important roles in ren ...

...abolism. EGCG significantly increased the protein expression of [[FOXO1]], Sirt1, [[CAT]], [[FABP1]], [[GSTA2]], [[ACSL1]] and [[CPT2]] but significantly de ...

...sms and pathways that are associated with the neuroprotective effects of [[SIRT1]]. ...is devastating condition. On the other hand, therapeutic upregulation of [[SIRT1]] might provide opportunities for the amelioration of Alzheimer's-disease-t ...

...by accelerated aging-related mechanisms. Sirtuins (SIRTs), particularly [[SIRT1]], [[SIRT3]], and [[SIRT6]], are well-known mediators of aging; however, li ...

...enoside Rg1 protects against Sca-1 HSC/HPC cell aging by regulating the [[SIRT1]]-[[FOXO3]] and [[SIRT3]]-[[SOD2]] signaling pathways in a γ-ray irradiati ...s age‑associated alterations and improves cardiac function by increasing [[SIRT1]] and [[SIRT3]] expression. ...

|title=[[SIRT1]] affects DNA methylation of polycomb group protein target genes, a hotspot ...genome, but particularly at PCGTs. Although the mechanism through which [[SIRT1]] has these effects is yet to be uncovered, this action is likely to contri ...

...ng; [[AMH]] level; estrous cycle; mTOR activity; [[GDF9]], [[BMP15]], LHR, Sirt1, and Cyp19a level; ROS and annexin V level; [[IL6]] and adiponectin level; ...

...by accelerated aging-related mechanisms. Sirtuins (SIRTs), particularly [[SIRT1]], [[SIRT3]], and [[SIRT6]], are well-known mediators of aging; however, li ...

...in-1 can induce cellular senescence in astrocytes possibly by inhibiting [[SIRT1]] and [[SIRT2]], which may play particular roles in brain aging and neurode ...ence and vascular aging, which is probably associated with repression of [[SIRT1]] expression and increased oxidative stress, and, thus, the activation of t ...

...levels) in parallel to decreased H S production and rejuvenation (LC3 and SIRT1)-related gene expression. In addition, [[CBS]] gene KD in ASC52telo cells r ...

...lleviates nonalcoholic steatohepatitis in middle-aged Apoe mice: role of [[SIRT1]]. |title=Activation of FoxO1/[[SIRT1]]/RANKL/OPG pathway may underlie the therapeutic effects of resveratrol on ...

...ibrosis by reducing renal tubular epithelial cell senescence through the [[SIRT1]]/PINK1/mitophagy axis. ...n involved inhibition of RTEC senescence, possibly through activation of [[SIRT1]]/PINK1/Parkin-mediated mitophagy. These findings suggest that pharmacologi ...

.... The three down-regulated mRNA in cellular aging, [[ELK1]], [[FOS]] and [[SIRT1]], were increased with tocotrienol-rich fraction treatment. Expression of [ ...