Aging genes 10

CD4

Identification of Key Genes and Potential New Biomarkers for Ovarian Aging: A Study Based on RNA-Sequencing Data. / 2020 / PubMed / Full text
Distinct Age-Related Epigenetic Signatures in CD4 and CD8 T Cells. / 2020 / PubMed / Full text
IL-1β-MyD88-mTOR Axis Promotes Immune-Protective IL-17A Foxp3 Cells During Mucosal Infection and Is Dysregulated With Aging. / 2020 / PubMed / Full text
Thymus involution sets the clock of declined immunity and repair with aging. / 25.11.2020 / PubMed / Full text
Food insecurity and T-cell dysregulation in women living with HIV on antiretroviral therapy. / 28.11.2020 / PubMed / Full text
Rapamycin Eyedrops Increased CD4 Foxp3 Cells and Prevented Goblet Cell Loss in the Aged Ocular Surface. / 24.11.2020 / PubMed / Full text
Antioxidants N-Acetylcysteine and Vitamin C Improve T Cell Commitment to Memory and Long-Term Maintenance of Immunological Memory in Old Mice. / 19.11.2020 / PubMed / Full text
Evolution of comorbidities in people living with HIV between 2004 and 2014: cross-sectional analyses from ANRS CO3 Aquitaine cohort. / 16.11.2020 / PubMed / Full text
Impact of age on CD4 recovery and viral suppression over time among adults living with HIV who initiated antiretroviral therapy in the African Cohort Study. / 12.11.2020 / PubMed / Full text
hPMSCs protects against D-galactose-induced oxidative damage of CD4 T cells through activating Akt-mediated Nrf2 antioxidant signaling. / 04.11.2020 / PubMed / Full text
Substantial gap in primary care: older adults with HIV presenting late to care. / 31.10.2020 / PubMed / Full text
Quantitative Digitography Measures Fine Motor Disturbances in Chronically Treated HIV Similar to Parkinson's Disease. / 2020 / PubMed / Full text
Monocyte and T Cell Immune Phenotypic Profiles Associated With Age Advancement Differ Between People With HIV, Lifestyle-Comparable Controls and Blood Donors. / 2020 / PubMed / Full text
HIV and three dimensions of Wisdom: Association with cognitive function and physical and mental well-being: For: Psychiatry Research. / 12.2020 / PubMed / Full text
CD8 T cells are present at low levels in the white matter with physiological and pathological aging. / 13.10.2020 / PubMed / Full text
Immunotherapy in older patients with cancer. / 26.07.2020 / PubMed / Full text
Multiple genetic programs contribute to CD4 T cell memory differentiation and longevity by maintaining T cell quiescence. / 11.2020 / PubMed / Full text
Conventional Treatment for Multiple Myeloma Drives Premature Aging Phenotypes and Metabolic Dysfunction in T Cells. / 2020 / PubMed / Full text
Immunosenescence: the role of age in multiple sclerosis. / 19.09.2020 / PubMed / Full text
Umbilical cord mesenchymal stem cells protect thymus structure and function in aged C57 mice by downregulating aging-related genes and upregulating autophagy- and anti-oxidative stress-related genes. / 14.09.2020 / PubMed / Full text
Impaired Cytotoxic CD8 T Cell Response in Elderly COVID-19 Patients. / 18.09.2020 / PubMed / Full text
What are the roles of antibodies versus a durable, high quality T-cell response in protective immunity against SARS-CoV-2? / 11.12.2020 / PubMed / Full text
Per2 Upregulation in Circulating Hematopoietic Progenitor Cells During Chronic HIV Infection. / 2020 / PubMed / Full text
COVID-19: age, Interleukin-6, C-reactive protein, and lymphocytes as key clues from a multicentre retrospective study. / 2020 / PubMed / Full text
Immunosenescence profiles are not associated with muscle strength, physical performance and sarcopenia risk in very old adults: The Newcastle 85+ Study. / 09.2020 / PubMed / Full text
Homeostasis and the functional roles of CD4 Treg cells in aging. / 10.2020 / PubMed / Full text
A Comprehensive Evaluation of the Impact of Bovine Milk Containing Different Beta-Casein Profiles on Gut Health of Ageing Mice. / 19.07.2020 / PubMed / Full text
Premature aging of circulating T cells predicts all-cause mortality in hemodialysis patients. / 13.07.2020 / PubMed / Full text
In-depth immune cellular profiling reveals sex-specific associations with frailty. / 2020 / PubMed / Full text
CD70 contributes to age-associated T cell defects and overwhelming inflammatory responses. / 19.06.2020 / PubMed / Full text
Comparison of Overall and Comorbidity-Free Life Expectancy Between Insured Adults With and Without HIV Infection, 2000-2016. / 01.06.2020 / PubMed / Full text
Comparative Analysis of Age-Related Changes in Lacrimal Glands and Meibomian Glands of a C57BL/6 Male Mouse Model. / 11.06.2020 / PubMed / Full text
Thymus aging in mice deficient in either EphB2 or EphB3, two master regulators of thymic epithelium development. / 10.2020 / PubMed / Full text
CD8 T-cell senescence and skewed lymphocyte subsets in young Dyskeratosis Congenita patients with PARN and DKC1 mutations. / 09.2020 / PubMed / Full text
Short-Term Environmental Enrichment is a Stronger Modulator of Brain Glial Cells and Cervical Lymph Node T Cell Subtypes than Exercise or Combined Exercise and Enrichment. / 25.05.2020 / PubMed / Full text
Viral and host factors related to the clinical outcome of COVID-19. / 07.2020 / PubMed / Full text
Use of comedications and potential drug-drug interactions in people living with HIV in China. / 07.2020 / PubMed / Full text
CD4 T helper 17 cell response of aged mice promotes prostate cancer cell migration and invasion. / 07.2020 / PubMed / Full text
The Rules of Human T Cell Fate [i]in vivo[/i]. / 2020 / PubMed / Full text
CD4/CD8 ratio, comorbidities, and aging in treated HIV infected individuals on viral suppression. / 21.04.2020 / PubMed / Full text
The effects of advanced maternal age on T-cell subsets at the maternal-fetal interface prior to term labor and in the offspring: a mouse study. / 07.2020 / PubMed / Full text
Structural and Functional Changes in the Mesenteric Lymph Nodes in Humans during Aging. / 03.2020 / PubMed / Full text
Neurocognitive Functioning is Associated with Self-Reported and Performance-Based Treatment Management Abilities in People Living with HIV with Low Health Literacy. / 24.07.2020 / PubMed / Full text
Blockade of Stat3 oncogene addiction induces cellular senescence and reveals a cell-nonautonomous activity suitable for cancer immunotherapy. / 2020 / PubMed / Full text
Age-related changes in T lymphocytes of patients with head and neck squamous cell carcinoma. / 2020 / PubMed / Full text
Immunological history governs human stem cell memory CD4 heterogeneity via the Wnt signaling pathway. / 10.02.2020 / PubMed / Full text
Estimating HIV Management and Comorbidity Costs Among Aging HIV Patients in the United States: A Systematic Review. / 02.2020 / PubMed / Full text
Sex Differences in People Aging With HIV. / 01.03.2020 / PubMed / Full text
Identification of Differentially Expressed miRNAs in the Response of Spleen CD4 T Cells to Electroacupuncture in Senescence-Accelerated Mice. / 03.2020 / PubMed / Full text
Thymus Involution and Intravenous Drug Abuse. / 03.2020 / PubMed / Full text
Depletion of CD4 T cells provides therapeutic benefits in aged mice after ischemic stroke. / 04.2020 / PubMed / Full text
Immunological and Virological Responses in Older HIV-Infected Adults Receiving Antiretroviral Therapy: An Evidence-Based Meta-Analysis. / 01.04.2020 / PubMed / Full text
African Mitochondrial DNA Haplogroup L2 Is Associated With Slower Decline of β-cell Function and Lower Incidence of Diabetes Mellitus in Non-Hispanic, Black Women Living With Human Immunodeficiency Virus. / 05.11.2020 / PubMed / Full text
DP1 Activation Reverses Age-Related Hypertension Via NEDD4L-Mediated T-Bet Degradation in T Cells. / 25.02.2020 / PubMed / Full text
An Emerging Concern-High Rates of Frailty among Middle-aged and Older Individuals Living with HIV. / 12.2019 / PubMed / Full text
Higher Acuity Resource Utilization With Older Age and Poorer HIV Control in Adolescents and Young Adults in the HIV Research Network. / 01.04.2020 / PubMed / Full text
Mitochondrial DNA Haplogroups and Frailty in Adults Living with HIV. / 03.2020 / PubMed / Full text
Gallic acid attenuates thymic involution in the d-galactose induced accelerated aging mice. / 01.2020 / PubMed / Full text
Mitochondrial mass governs the extent of human T cell senescence. / 02.2020 / PubMed / Full text
T cells and immune functions of plasma extracellular vesicles are differentially modulated from adults to centenarians. / 27.11.2019 / PubMed / Full text
Defects in Antiviral T Cell Responses Inflicted by Aging-Associated miR-181a Deficiency. / 19.11.2019 / PubMed / Full text
Increased Prevalence of Neurocognitive Impairment in Aging People Living With Human Immunodeficiency Virus: The ANRS EP58 HAND 55-70 Study. / 10.06.2020 / PubMed / Full text
Age-associated changes in human CD4 T cells point to mitochondrial dysfunction consequent to impaired autophagy. / 09.11.2019 / PubMed / Full text
Sex Differences in the Blood Transcriptome Identify Robust Changes in Immune Cell Proportions with Aging and Influenza Infection. / 12.11.2019 / PubMed / Full text
Going Beyond Giving Antiretroviral Therapy: Multimorbidity in Older People Aging with HIV in Nigeria. / 03.2020 / PubMed / Full text
Alterations in composition of immune cells and impairment of anti-tumor immune response in aged oral cancer-bearing mice. / 12.2019 / PubMed / Full text
LTA1 is a safe, intranasal enterotoxin-based adjuvant that improves vaccine protection against influenza in young, old and B-cell-depleted (μMT) mice. / 22.10.2019 / PubMed / Full text
Thymus Imaging Detection and Size Is Inversely Associated With Metabolic Syndrome and Frailty in People With HIV. / 10.2019 / PubMed / Full text
Alterations in peripheral T cell and B cell subsets in patients with osteoarthritis. / 02.2020 / PubMed / Full text
Short Communication: Carotid Intima-Media Thickness Is Not Associated with Neurocognitive Impairment Among People Older than 50 Years With and Without HIV Infection from Thailand. / 11-12.2019 / PubMed / Full text
Implications of Immune Checkpoint Expression During Aging in HIV-Infected People on Antiretroviral Therapy. / 11-12.2019 / PubMed / Full text
Age-related alterations in human gut CD4 T cell phenotype, T helper cell frequencies, and functional responses to enteric bacteria. / 01.2020 / PubMed / Full text
Determinants of blood telomere length in antiretroviral treatment-naïve HIV-positive participants enrolled in the NEAT 001/ANRS 143 clinical trial. / 11.2019 / PubMed / Full text
Human T Cell Differentiation Negatively Regulates Telomerase Expression Resulting in Reduced Activation-Induced Proliferation and Survival. / 2019 / PubMed / Full text
Short Communication: Getting Older with HIV: Increasing Frequency of Comorbidities and Polypharmacy in Brazilian HIV Patients. / 11-12.2019 / PubMed / Full text
Gait Speed Decline Is Associated with Hemoglobin A1C, Neurocognitive Impairment, and Black Race in Persons with HIV. / 11-12.2019 / PubMed / Full text
Noncommunicable Diseases Burden and Risk Factors in a Cohort of HIV+ Elderly Patients in Malawi. / 11-12.2019 / PubMed / Full text
Aging promotes reorganization of the CD4 T cell landscape toward extreme regulatory and effector phenotypes. / 08.2019 / PubMed / Full text
Prevalence of hypertension and cardiovascular risk factors among long-term AIDS survivors: A report from the field. / 10.2019 / PubMed / Full text

TNF

Naringenin alleviates nonalcoholic steatohepatitis in middle-aged Apoe mice: role of SIRT1. / 18.11.2020 / PubMed / Full text
Protective role of microglial HO-1 blockade in aging: Implication of iron metabolism. / 06.11.2020 / PubMed / Full text
Anti-aging effect of DL-β-hydroxybutyrate against hepatic cellular senescence induced by D-galactose or γ-irradiation via autophagic flux stimulation in male rats. / 01-02.2021 / PubMed / Full text
Exploring the extensive crosstalk between the antagonistic cytokines- TGF-β and TNF-α in regulating cancer pathogenesis. / 03.11.2020 / PubMed / Full text
Long non-coding RNA SNHG29 regulates cell senescence via p53/p21 signaling in spontaneous preterm birth. / 15.10.2020 / PubMed / Full text
Cognition Is Associated With Peripheral Immune Molecules in Healthy Older Adults: A Cross-Sectional Study. / 2020 / PubMed / Full text
Anti-aging effects of [i]Ribes meyeri[/i] anthocyanins on neural stem cells and aging mice. / 12.09.2020 / PubMed / Full text
Effects of a four week detraining period on physical, metabolic, and inflammatory profiles of elderly women who regularly participate in a program of strength training. / 2020 / PubMed / Full text
Contribution of Porphyromonas gingivalis lipopolysaccharide to experimental periodontitis in relation to aging. / 26.08.2020 / PubMed / Full text
New MoDC-Targeting TNF Fusion Proteins Enhance Cyclic Di-GMP Vaccine Adjuvanticity in Middle-Aged and Aged Mice. / 2020 / PubMed / Full text
Cognitive impairment in elderly patients with rheumatic disease and the effect of disease-modifying anti-rheumatic drugs. / 30.08.2020 / PubMed / Full text
Cotinine ameliorates memory and learning impairment in senescent mice. / 11.2020 / PubMed / Full text
Kynurenines link chronic inflammation to functional decline and physical frailty. / 20.08.2020 / PubMed / Full text
Voluntary exercise training attenuated the middle-aged maturity-induced cardiac apoptosis. / 15.10.2020 / PubMed / Full text
Preclinical Evaluation of a Food-Derived Functional Ingredient to Address Skeletal Muscle Atrophy. / 29.07.2020 / PubMed / Full text
Childhood survivors of high-risk neuroblastoma show signs of immune recovery and not immunosenescence. / 12.2020 / PubMed / Full text
FK506 induces lung lymphatic endothelial cell senescence and downregulates LYVE-1 expression, with associated decreased hyaluronan uptake. / 31.07.2020 / PubMed / Full text
Late-onset hypogonadism: Reductio ad absurdum of the cardiovascular risk-benefit of testosterone replacement therapy. / 11.2020 / PubMed / Full text
Doxorubicin generates senescent microglia that exhibit altered proteomes, higher levels of cytokine secretion, and a decreased ability to internalize amyloid β. / 15.10.2020 / PubMed / Full text
Time restricted feeding provides a viable alternative to alternate day fasting when evaluated in terms of redox homeostasis in rats. / 16.07.2020 / PubMed / Full text
Associations Between Plasma Immunomodulatory and Inflammatory Mediators With VACS Index Scores Among Older HIV-Infected Adults on Antiretroviral Therapy. / 2020 / PubMed / Full text
Chrysin Impact on Oxidative and Inflammation Damages in the Liver of Aged Male Rats. / 17.07.2020 / PubMed / Full text
Correction of immunosuppression in aged septic rats by human ghrelin and growth hormone through the vagus nerve-dependent inhibition of TGF-β production. / 16.07.2020 / PubMed / Full text
Epigenetics of neuroinflammation: Immune response, inflammatory response and cholinergic synaptic involvement evidenced by genome-wide DNA methylation analysis of delirious inpatients. / 10.2020 / PubMed / Full text
[i]Andrographis paniculata[/i] and Its Bioactive Diterpenoids Against Inflammation and Oxidative Stress in Keratinocytes. / 17.06.2020 / PubMed / Full text
Etanercept improves aging-induced cognitive deficits by reducing inflammation and vascular dysfunction in rats. / 01.10.2020 / PubMed / Full text
Bacterial antigen translocation and age as BMI-independent contributing factors on systemic inflammation in NAFLD patients. / 09.2020 / PubMed / Full text
Bone marrow mesenchymal stem cells improve thymus and spleen function of aging rats through affecting P21/PCNA and suppressing oxidative stress. / 19.06.2020 / PubMed / Full text
Glycolic acid adjusted to pH 4 stimulates collagen production and epidermal renewal without affecting levels of proinflammatory TNF-alpha in human skin explants. / 24.06.2020 / PubMed / Full text
A20 of nucleus pulposus cells plays a self-protection role via the nuclear factor-kappa B pathway in the inflammatory microenvironment. / 05.2020 / PubMed / Full text
Age-associated decline in neural, endocrine, and immune responses in men and women: Involvement of intracellular signaling pathways. / 15.08.2020 / PubMed / Full text
Classical and lectin complement pathways and markers of inflammation for investigation of susceptibility to infections among healthy older adults. / 2020 / PubMed / Full text
Activation of FoxO1/SIRT1/RANKL/OPG pathway may underlie the therapeutic effects of resveratrol on aging-dependent male osteoporosis. / 12.06.2020 / PubMed / Full text
The senescence-associated secretome as an indicator of age and medical risk. / 18.06.2020 / PubMed / Full text
Exercise Partially Rejuvenates Muscle Stem Cells. / 06.2020 / PubMed / Full text
Brazilian berry extract (Myrciaria jaboticaba): A promising therapy to minimize prostatic inflammation and oxidative stress. / 08.2020 / PubMed / Full text
Potential therapeutic effects of endothelial cells trans-differentiated from Wharton's Jelly-derived mesenchymal stem cells on altered vascular functions in aged diabetic rat model. / 2020 / PubMed / Full text
[Effect of fragmented sleep on postoperative cognitive function and central neuroinflammation]. / 05.05.2020 / PubMed / Full text
Can blocking inflammation enhance immunity during aging? / 05.2020 / PubMed / Full text
[FAS- and TNF-dependent ways participation in apoptosis mechanisms in hypotalumus in physiological and pathological aging.] / 2020 / PubMed
Ultrasound-guided continuous thoracic paravertebral block alleviates postoperative delirium in elderly patients undergoing esophagectomy: A randomized controlled trial. / 04.2020 / PubMed / Full text
17β-Estradiol improves insulin signalling and insulin resistance in the aged female hearts: Role of inflammatory and anti-inflammatory cytokines. / 15.07.2020 / PubMed / Full text
Synergistic Antitumor Efficacy of Magnetohyperthermia and Poly(lactic-co-glycolic acid)-Encapsulated Selol in Ehrlich Breast Adenocarcinoma Treatment in Elderly Swiss Mice. / 01.02.2020 / PubMed / Full text
Pinitol suppresses TNF-α-induced chondrocyte senescence. / 19.03.2020 / PubMed / Full text
[Aging of skin fibroblasts: genetic and epigenetic factors.] / 2019 / PubMed
Functional and traditional training improve muscle power and reduce proinflammatory cytokines in older women: A randomized controlled trial. / 01.07.2020 / PubMed / Full text
Associations of TNF-α -308 G>A and TNF-β 252 A>G with Physical Function and BNP-Rugao Longevity and Ageing Study. / 2020 / PubMed / Full text
3D TECA hydrogel reduces cellular senescence and enhances fibroblasts migration in wound healing. / 07.2018 / PubMed / Full text
Regulatory Effect of Anwulignan on the Immune Function Through Its Antioxidation and Anti-Apoptosis in D-Galactose-Induced Aging Mice. / 2020 / PubMed / Full text
Pretreatment Frailty Is Independently Associated With Increased Risk of Infections After Immunosuppression in Patients With Inflammatory Bowel Diseases. / 06.2020 / PubMed / Full text
The Citrus Flavonoid Naringenin Protects the Myocardium from Ageing-Dependent Dysfunction: Potential Role of SIRT1. / 2020 / PubMed / Full text
In the Absence of a TCR Signal IL-2/IL-12/18-Stimulated γδ T Cells Demonstrate Potent Anti-Tumoral Function Through Direct Killing and Senescence Induction in Cancer Cells. / 04.01.2020 / PubMed / Full text
Aging is associated with loss of beneficial effects of estrogen on leptin responsiveness in mice fed high fat diet: Role of estrogen receptor α and cytokines. / 03.2020 / PubMed / Full text
Mitochondrial Dysfunction and Alpha-Lipoic Acid: Beneficial or Harmful in Alzheimer's Disease? / 2019 / PubMed / Full text
Design, synthesis and evaluation of diosgenin carbamate derivatives as multitarget anti-Alzheimer's disease agents. / 01.02.2020 / PubMed / Full text
Oral Administration of Okara Soybean By-Product Attenuates Cognitive Impairment in a Mouse Model of Accelerated Aging. / 03.12.2019 / PubMed / Full text
Electric vagal nerve stimulation inhibits inflammation and improves early postoperation cognitive dysfunction in aged rats. / 23.11.2019 / PubMed / Full text
Metformin decreases LPS-induced inflammatory response in rabbit annulus fibrosus stem/progenitor cells by blocking HMGB1 release. / 26.11.2019 / PubMed / Full text
The effects of blueberry and strawberry serum metabolites on age-related oxidative and inflammatory signaling in vitro. / 11.12.2019 / PubMed / Full text
Arsenic induces human chondrocyte senescence and accelerates rat articular cartilage aging. / 01.2020 / PubMed / Full text
Bone Benefits of Fish Oil Supplementation Depend on its EPA and DHA Content. / 08.11.2019 / PubMed / Full text
Inflammaging phenotype in rhesus macaques is associated with a decline in epithelial barrier-protective functions and increased pro-inflammatory function in CD161-expressing cells. / 12.2019 / PubMed / Full text
Single-cell transcriptomics reveals expansion of cytotoxic CD4 T cells in supercentenarians. / 26.11.2019 / PubMed / Full text
Gut microbiota combined with metabolomics reveals the metabolic profile of the normal aging process and the anti-aging effect of FuFang Zhenshu TiaoZhi(FTZ) in mice. / 01.2020 / PubMed / Full text
Intervertebral disc ageing and degeneration: The antiapoptotic effect of oestrogen. / 01.2020 / PubMed / Full text
MicroRNA 16-5p is upregulated in calorie-restricted mice and modulates inflammatory cytokines of macrophages. / 30.01.2020 / PubMed / Full text
Aerobic exercise modulates cytokine profile and sleep quality in elderly. / 06.2019 / PubMed / Full text
Trehalose targets Nrf2 signal to alleviate d-galactose induced aging and improve behavioral ability. / 01.01.2020 / PubMed / Full text
Anti-Inflammatory and Anti-Aging Evaluation of Pigment-Protein Complex Extracted from [i]Chlorella Pyrenoidosa[/i]. / 16.10.2019 / PubMed / Full text
Inflammatory mediators and the risk of falls among older women with acute low back pain: data from Back Complaints in the Elders (BACE)-Brazil. / 03.2020 / PubMed / Full text
Acetylcholinesterase inhibitors targeting the cholinergic anti-inflammatory pathway: a new therapeutic perspective in aging-related disorders. / 03.10.2019 / PubMed / Full text
Study on Metabolic Trajectory of Liver Aging and the Effect of Fufang Zhenzhu Tiaozhi on Aging Mice. / 2019 / PubMed / Full text
Systemic Tumor Necrosis Factor-Alpha Trajectories Relate to Brain Health in Typically Aging Older Adults. / 13.07.2020 / PubMed / Full text
Targeting senescence improves angiogenic potential of adipose-derived mesenchymal stem cells in patients with preeclampsia. / 14.09.2019 / PubMed / Full text
Suppression of gut dysbiosis by Bifidobacterium longum alleviates cognitive decline in 5XFAD transgenic and aged mice. / 14.08.2019 / PubMed / Full text
Moderate hyperoxia induces senescence in developing human lung fibroblasts. / 01.11.2019 / PubMed / Full text
Aging-related carcinoembryonic antigen-related cell adhesion molecule 1 signaling promotes vascular dysfunction. / 12.2019 / PubMed / Full text
Microglia Express Insulin-Like Growth Factor-1 in the Hippocampus of Aged APP /PS1 Transgenic Mice. / 2019 / PubMed / Full text
Age- and diet-specific effects of chronic exposure to chlorpyrifos on hormones, inflammation and gut microbiota in rats. / 09.2019 / PubMed / Full text

HR

Patients with hip fracture and total hip arthroplasty surgery differ in anthropometric, but not cardiovascular screening abnormalities. / 02.12.2020 / PubMed / Full text
Clinical Role of Lung Ultrasound for the Diagnosis and Prognosis of Coronavirus Disease Pneumonia in Elderly Patients: A Pivotal Study. / 03.12.2020 / PubMed / Full text
The Relationship of Accelerometer-Assessed Standing Time With and Without Ambulation and Mortality: The WHI OPACH Study. / 12.10.2020 / PubMed / Full text
Age-related myofiber atrophy in old mice is reversed by ten weeks voluntary high-resistance wheel running. / 09.11.2020 / PubMed / Full text
Predicted Skeletal Muscle Mass and 4-Year Cardiovascular Disease Incidence in Middle-Aged and Elderly Participants of IKARIA Prospective Epidemiological Study: The Mediating Effect of Sex and Cardiometabolic Factors. / 27.10.2020 / PubMed / Full text
Obesity is associated with early hip fracture risk in postmenopausal women: a 25-year follow-up. / 23.10.2020 / PubMed / Full text
ATM inhibition synergizes with fenofibrate in high grade serous ovarian cancer cells. / 09.2020 / PubMed / Full text
Effectiveness of adjuvant FOLFOX vs 5FU/LV in adults over age 65 with stage II and III colon cancer using a novel hybrid approach. / 12.2020 / PubMed / Full text
Age, Frailty, and Comorbidity as Prognostic Factors for Short-Term Outcomes in Patients With Coronavirus Disease 2019 in Geriatric Care. / 11.2020 / PubMed / Full text
Clinical and demographic parameters predict the progression from mild cognitive impairment to dementia in elderly patients. / 12.09.2020 / PubMed / Full text
Plasma Dehydroepiandrosterone Sulfate and Cardiovascular Disease Risk in Older Men and Women. / 01.12.2020 / PubMed / Full text
High intensity interval training combined with L-citrulline supplementation: Effects on physical performance in healthy older adults. / 15.10.2020 / PubMed / Full text
Associations of blood pressure with risk of injurious falls in old age vary by functional status: A cohort study. / 15.10.2020 / PubMed / Full text
Epigenetic age acceleration and clinical outcomes in gliomas. / 2020 / PubMed / Full text
Do Stairs Inhibit Seniors Who Live on Upper Floors From Going Out? / 10.2020 / PubMed / Full text
Age-specific acute changes in carotid-femoral pulse wave velocity with head-up tilt. / 07.07.2020 / PubMed / Full text
Pre-frailty status increases the risk of rehospitalization in patients after elective cardiac surgery without complication. / 06.2020 / PubMed / Full text
Comparative Performance of Creatinine-Based GFR Estimation Equations in Exceptional Longevity: The Rugao Longevity and Ageing Study. / 2020 / PubMed / Full text
Sex-and race-specific associations of protein intake with change in muscle mass and physical function in older adults: the Health, Aging, and Body Composition (Health ABC) Study. / 01.07.2020 / PubMed / Full text
Deterioration of bone microstructure by aging and menopause in Japanese healthy women: analysis by HR-pQCT. / 11.2020 / PubMed / Full text
Association between Low Protein Intake and Mortality in Patients with Type 2 Diabetes. / 01.06.2020 / PubMed / Full text
CAUSES, mortality rates and risk factors of death in community-dwelling Europeans aged 50 years and over: Results from the Survey of Health, Ageing and Retirement in Europe 2013-2015. / 07-08.2020 / PubMed / Full text
Estimation of Wave Condition Number From Pressure Waveform Alone and Its Changes With Advancing Age in Healthy Women and Men. / 2020 / PubMed / Full text
Extended in vitro culture of primary human mesenchymal stem cells downregulates Brca1-related genes and impairs DNA double-strand break recognition. / 07.2020 / PubMed / Full text
Effect of artificial dawn light on cardiovascular function, alertness, and balance in middle-aged and older adults. / 13.10.2020 / PubMed / Full text
Heart Rate Performance Curve Is Dependent on Age, Sex, and Performance. / 2020 / PubMed / Full text
Physical activity trajectories, mortality, hospitalization, and disability in the Toledo Study of Healthy Aging. / 08.2020 / PubMed / Full text
U-Shaped Association of Plasma Testosterone, and no Association of Plasma Estradiol, with Incidence of Fractures in Men. / 01.05.2020 / PubMed / Full text
Pregnancy-Related Bone Mineral and Microarchitecture Changes in Women Aged 30 to 45 Years. / 07.2020 / PubMed / Full text
Analysis of the world record time for combined father and son marathon. / 01.02.2020 / PubMed / Full text
Age-related reductions in heart rate variability do not worsen during exposure to humid compared to dry heat: A secondary analysis. / 2019 / PubMed / Full text
Efficacy and Safety of Dapagliflozin in the Elderly: Analysis From the DECLARE-TIMI 58 Study. / 02.2020 / PubMed / Full text
Validity of Prediction Equations of Maximal Heart Rate in Physically Active Female Adolescents and the Role of Maturation. / 13.11.2019 / PubMed / Full text
Base excision repair but not DNA double-strand break repair is impaired in aged human adipose-derived stem cells. / 02.2020 / PubMed / Full text
Urban-Rural Differences in Hip Fracture Mortality: A Nationwide NOREPOS Study. / 11.2019 / PubMed / Full text
Malnutrition as a Strong Predictor of the Onset of Sarcopenia. / 27.11.2019 / PubMed / Full text
Acclimation to a thermoneutral environment abolishes age-associated alterations in heart rate and heart rate variability in conscious, unrestrained mice. / 02.2020 / PubMed / Full text
Long-term dementia risk prediction by the LIBRA score: A 30-year follow-up of the CAIDE study. / 02.2020 / PubMed / Full text
Kidney function and its association to imminent, short- and long-term fracture risk-a longitudinal study in older women. / 01.2020 / PubMed / Full text
Oxidatively Damaged DNA/RNA and 8-Isoprostane Levels Are Associated With the Development of Type 2 Diabetes at Older Age: Results From a Large Cohort Study. / 01.2020 / PubMed / Full text
Associations of vigorous physical activity with all-cause, cardiovascular and cancer mortality among 64 913 adults. / 2019 / PubMed / Full text
Reduced cerebrovascular and cardioventilatory responses to intermittent hypoxia in elderly. / 01.2020 / PubMed / Full text
Vestibulo-sympathetic reflex in patients with bilateral vestibular loss. / 01.11.2019 / PubMed / Full text
Heart rate and blood pressure in male Ts65Dn mice: a model to investigate cardiovascular responses in Down syndrome. / 09.2019 / PubMed / Full text
Body weight at 10 years of age and change in body composition between 8 and 10 years of age were related to survival in a longitudinal study of 39 Labrador retriever dogs. / 09.09.2019 / PubMed / Full text
Dietary diversity offsets the adverse mortality risk among older indigenous Taiwanese. / 2019 / PubMed / Full text
Independent and joint effects of vascular and cardiometabolic risk factor pairs for risk of all-cause dementia: a prospective population-based study. / 10.2019 / PubMed / Full text
Work Ability and Job Survival: Four-Year Follow-Up. / 28.08.2019 / PubMed / Full text
Predictivity of bioimpedance phase angle for incident disability in older adults. / 02.2020 / PubMed / Full text

APOE

Polygenic risk score of longevity predicts longer survival across an age-continuum. / 20.11.2020 / PubMed / Full text
Association Between APOE Alleles and Change of Neuropsychological Tests in the Long Life Family Study. / 17.11.2020 / PubMed / Full text
The APOE gene cluster responds to air pollution factors in mice with coordinated expression of genes that differs by age in humans. / 20.11.2020 / PubMed / Full text
Homozygosity in the [i]APOE[/i] 3 Polymorphism Is Associated With Less Depression and Higher Serum Low-Density Lipoprotein in Chinese Elderly Schizophrenics. / 2020 / PubMed / Full text
Effect of apolipoprotein E polymorphism on cognition and brain in the Cambridge Centre for Ageing and Neuroscience cohort. / 01-12.2020 / PubMed / Full text
Cardiovascular risk factors and APOE-ε4 status affect memory functioning in aging via changes to temporal stem diffusion. / 18.10.2020 / PubMed / Full text
APOE [i]ε[/i]4 and resting-state functional connectivity in racially/ethnically diverse older adults. / 2020 / PubMed / Full text
Predictors of Olfactory Decline in Aging: A Longitudinal Population-Based Study. / 13.11.2020 / PubMed / Full text
When Culture Influences Genes: Positive Age Beliefs Amplify the Cognitive-Aging Benefit of APOE ε2. / 14.09.2020 / PubMed / Full text
Age and the association between apolipoprotein E genotype and Alzheimer disease: A cerebrospinal fluid biomarker-based case-control study. / 08.2020 / PubMed / Full text
Estimating the potential for dementia prevention through modifiable risk factors elimination in the real-world setting: a population-based study. / 07.08.2020 / PubMed / Full text
Machine learning-based estimation of cognitive performance using regional brain MRI markers: the Northern Manhattan Study. / 01.08.2020 / PubMed / Full text
Effects of an APOE Promoter Polymorphism on Fronto-Parietal Functional Connectivity During Nondemented Aging. / 2020 / PubMed / Full text
The relationship of parental longevity with the aging brain-results from UK Biobank. / 10.2020 / PubMed / Full text
Alzheimer's Patient Microglia Exhibit Enhanced Aging and Unique Transcriptional Activation. / 30.06.2020 / PubMed / Full text
Relationships Between Plasma Lipids Species, Gender, Risk Factors, and Alzheimer's Disease. / 2020 / PubMed / Full text
Effects of sex, age, and apolipoprotein E genotype on hippocampal parenchymal fraction in cognitively normal older adults. / 30.07.2020 / PubMed / Full text
Cognitive Health of Nonagenarians in Southern Italy: A Descriptive Analysis from a Cross-Sectional, Home-Based Pilot Study of Exceptional Longevity (Cilento Initiative on Aging Outcomes Or CIAO). / 05.05.2020 / PubMed / Full text
Apolipoprotein E and Health in Older Men: The Concord Health and Ageing in Men Project. / 25.09.2020 / PubMed / Full text
CSF amyloid is a consistent predictor of white matter hyperintensities across the disease course from aging to Alzheimer's disease. / 07.2020 / PubMed / Full text
Association of Cardiovascular Risk Factors with Cerebral Perfusion in Whites and African Americans. / 2020 / PubMed / Full text
Alzheimer's Risk Factors Age, APOE Genotype, and Sex Drive Distinct Molecular Pathways. / 03.06.2020 / PubMed / Full text
Less agreeable, better preserved? A PET amyloid and MRI study in a community-based cohort. / 05.2020 / PubMed / Full text
Physical Activity as Moderator of the Association Between APOE and Cognitive Decline in Older Adults: Results from Three Longitudinal Cohort Studies. / 25.09.2020 / PubMed / Full text
Longitudinal Maintenance of Cognitive Health in Centenarians in the 100-plus Study. / 05.02.2020 / PubMed / Full text
Interaction of APOE, cerebral blood flow, and cortical thickness in the entorhinal cortex predicts memory decline. / 04.2020 / PubMed / Full text
Determinants of mesial temporal lobe volume loss in older individuals with preserved cognition: a longitudinal PET amyloid study. / 03.2020 / PubMed / Full text
Long-term exposure to ambient air pollution, APOE-ε4 status, and cognitive decline in a cohort of older adults in northern Manhattan. / 03.2020 / PubMed / Full text
Evidence in support of chromosomal sex influencing plasma based metabolome vs APOE genotype influencing brain metabolome profile in humanized APOE male and female mice. / 2020 / PubMed / Full text
APOE region molecular signatures of Alzheimer's disease across races/ethnicities. / 03.2020 / PubMed / Full text
Varying Effects of APOE Alleles on Extreme Longevity in European Ethnicities. / 13.11.2019 / PubMed / Full text
Prospective Evaluation of Cognitive Health and Related Factors in Elderly at Risk for Developing Alzheimer's Dementia: A Longitudinal Cohort Study. / 2019 / PubMed / Full text
Association of Cardiovascular and Alzheimer's Disease Risk Factors with Intracranial Arterial Blood Flow in Whites and African Americans. / 2019 / PubMed / Full text
Is Ongoing Anticholinergic Burden Associated With Greater Cognitive Decline and Dementia Severity in Mild to Moderate Alzheimer's Disease? / 17.04.2020 / PubMed / Full text
Multicenter Alzheimer's and Parkinson's disease immune biomarker verification study. / 02.2020 / PubMed / Full text
Prospective Memory: Age related change is influenced by APOE genotype. / 09.2020 / PubMed / Full text
Education Moderates the Relation Between APOE ɛ4 and Memory in Nondemented Non-Hispanic Black Older Adults. / 2019 / PubMed / Full text
Apolipoprotein E ε4 allele effects on longitudinal cognitive trajectories are sex and age dependent. / 12.2019 / PubMed / Full text
Interactive effect of age and APOE-ε4 allele load on white matter myelin content in cognitively normal middle-aged subjects. / 2019 / PubMed / Full text
APOE modifies the interaction of entorhinal cerebral blood flow and cortical thickness on memory function in cognitively normal older adults. / 15.11.2019 / PubMed / Full text
When time's arrow doesn't bend: APOE-ε4 influences episodic memory before old age. / 10.2019 / PubMed / Full text
Cognitive-Motor Integration Performance Is Affected by Sex, APOE Status, and Family History of Dementia. / 2019 / PubMed / Full text
Associations among amyloid status, age, and longitudinal regional brain atrophy in cognitively unimpaired older adults. / 10.2019 / PubMed / Full text
Cognitive function and neuropathological outcomes: a forward-looking approach. / 12.2019 / PubMed / Full text
APOE gene-dependent BOLD responses to a breath-hold across the adult lifespan. / 2019 / PubMed / Full text

MSC

Rejuvenation of Senescent Endothelial Progenitor Cells by Extracellular Vesicles Derived From Mesenchymal Stromal Cells. / 11.2020 / PubMed / Full text
Extracellular vesicles derived from bone marrow mesenchymal stem cells enhance myelin maintenance after cortical injury in aged rhesus monkeys. / 29.11.2020 / PubMed / Full text
TPP1 Enhances the Therapeutic Effects of Transplanted Aged Mesenchymal Stem Cells in Infarcted Hearts via the MRE11/AKT Pathway. / 2020 / PubMed / Full text
Aging-Affected MSC Functions and Severity of Periodontal Tissue Destruction in a Ligature-Induced Mouse Periodontitis Model. / 30.10.2020 / PubMed / Full text
Human placenta-derived mesenchymal stem cells stimulate ovarian function via miR-145 and bone morphogenetic protein signaling in aged rats. / 05.11.2020 / PubMed / Full text
Mesenchymal Stromal Cells as Critical Contributors to Tissue Regeneration. / 2020 / PubMed / Full text
The biology of human hair greying. / 23.09.2020 / PubMed / Full text
[i]Tsc1[/i] Regulates the Proliferation Capacity of Bone-Marrow Derived Mesenchymal Stem Cells. / 10.09.2020 / PubMed / Full text
The role of mitochondrial dysfunction in mesenchymal stem cell senescence. / 12.2020 / PubMed / Full text
Metabolic syndrome increases senescence-associated micro-RNAs in extracellular vesicles derived from swine and human mesenchymal stem/stromal cells. / 12.08.2020 / PubMed / Full text
Functional heterogeneity of mesenchymal stem cells from natural niches to culture conditions: implications for further clinical uses. / 22.07.2020 / PubMed / Full text
Functional crosstalk between mTORC1/p70S6K pathway and heterochromatin organization in stress-induced senescence of MSCs. / 13.07.2020 / PubMed / Full text
Increased cellular senescence in the murine and human stenotic kidney: Effect of mesenchymal stem cells. / 02.2021 / PubMed / Full text
Intrinsic Type 1 Interferon (IFN1) Profile of Uncultured Human Bone Marrow CD45 CD271 Multipotential Stromal Cells (BM-MSCs): The Impact of Donor Age, Culture Expansion and IFNα and IFNβ Stimulation. / 15.07.2020 / PubMed / Full text
Facial rejuvenation using stem cell conditioned media combined with skin needling: A split-face comparative study. / 09.2020 / PubMed / Full text
Mesenchymal Stem Cell Senescence and Rejuvenation: Current Status and Challenges. / 2020 / PubMed / Full text
The changing epigenetic landscape of Mesenchymal Stem/Stromal Cells during aging. / 08.2020 / PubMed / Full text
Dual Role of Autophagy in Regulation of Mesenchymal Stem Cell Senescence. / 2020 / PubMed / Full text
Molecular Aspects of Adipose-Derived Stromal Cell Senescence in a Long-Term Culture: A Potential Role of Inflammatory Pathways. / 01-12.2020 / PubMed / Full text
Human Obesity Induces Dysfunction and Early Senescence in Adipose Tissue-Derived Mesenchymal Stromal/Stem Cells. / 2020 / PubMed / Full text
miR-155-5p inhibition rejuvenates aged mesenchymal stem cells and enhances cardioprotection following infarction. / 04.2020 / PubMed / Full text
Mesenchymal Stem Cell Derived Extracellular Vesicles in Aging. / 2020 / PubMed / Full text
Molecular Mechanisms Contributing to Mesenchymal Stromal Cell Aging. / 21.02.2020 / PubMed / Full text
Inhibition of DNA Methyltransferase by RG108 Promotes Pluripotency-Related Character of Porcine Bone Marrow Mesenchymal Stem Cells. / 04.2020 / PubMed / Full text
Extracellular Vesicles of Stem Cells to Prevent BRONJ. / 05.2020 / PubMed / Full text
Ginsenoside Rg1 as an Effective Regulator of Mesenchymal Stem Cells. / 2019 / PubMed / Full text
The Importance of Stem Cell Senescence in Regenerative Medicine. / 2020 / PubMed / Full text
Control of mesenchymal stem cell biology by histone modifications. / 2020 / PubMed / Full text
Impact of mesenchymal stem cell senescence on inflammaging. / 02.2020 / PubMed / Full text
Late Rescue Therapy with Cord-Derived Mesenchymal Stromal Cells for Established Lung Injury in Experimental Bronchopulmonary Dysplasia. / 15.03.2020 / PubMed / Full text
Low-Level Radiofrequency Exposure Does Not Induce Changes in MSC Biology: An in vitro Study for the Prevention of NIR-Related Damage. / 2019 / PubMed / Full text
Macrophage migration inhibitory factor rejuvenates aged human mesenchymal stem cells and improves myocardial repair. / 27.12.2019 / PubMed / Full text
Influence of olive oil and its components on mesenchymal stem cell biology. / 26.12.2019 / PubMed / Full text
Epigenetic Regulation of Mesenchymal Stem Cell Homeostasis. / 02.2020 / PubMed / Full text
Mesenchymal Stem Cells: Allogeneic MSC May Be Immunosuppressive but Autologous MSC Are Dysfunctional in Lupus Patients. / 2019 / PubMed / Full text
Effects of high glucose conditions on the expansion and differentiation capabilities of mesenchymal stromal cells derived from rat endosteal niche. / 21.11.2019 / PubMed / Full text
Autophagy inhibits the mesenchymal stem cell aging induced by D-galactose through ROS/JNK/p38 signalling. / 03.2020 / PubMed / Full text
Enhancing survival, engraftment, and osteogenic potential of mesenchymal stem cells. / 26.10.2019 / PubMed / Full text
Mesenchymal stem cell senescence alleviates their intrinsic and seno-suppressive paracrine properties contributing to osteoarthritis development. / 22.10.2019 / PubMed / Full text
Embryonic stem cell-derived extracellular vesicles enhance the therapeutic effect of mesenchymal stem cells. / 2019 / PubMed / Full text
Survival of aging CD264 and CD264 populations of human bone marrow mesenchymal stem cells is independent of colony-forming efficiency. / 01.2020 / PubMed / Full text
Differential effects of extracellular vesicles from aging and young mesenchymal stem cells in acute lung injury. / 29.09.2019 / PubMed / Full text
Connexin43 is Dispensable for Early Stage Human Mesenchymal Stem Cell Adipogenic Differentiation But is Protective against Cell Senescence. / 11.09.2019 / PubMed / Full text
Maintained Properties of Aged Dental Pulp Stem Cells for Superior Periodontal Tissue Regeneration. / 08.2019 / PubMed / Full text

SIRT1

Anthocyanins attenuate endothelial dysfunction through regulation of uncoupling of nitric oxide synthase in aged rats. / 03.12.2020 / PubMed / Full text
Sirtuins and Their Implications in Neurodegenerative Diseases from a Drug Discovery Perspective. / 05.12.2020 / PubMed / Full text
Effects of alpha-mangostin on memory senescence induced by high glucose in human umbilical vein endothelial cells. / 10.2020 / PubMed / Full text
SIRT1 Activation Using CRISPR/dCas9 Promotes Regeneration of Human Corneal Endothelial Cells through Inhibiting Senescence. / 04.11.2020 / PubMed / Full text
Histone Deacetylase SIRT1, Smooth Muscle Cell Function, and Vascular Diseases. / 2020 / PubMed / Full text
6,4'-dihydroxy-7-methoxyflavanone protects against H O -induced cellular senescence by inducing SIRT1 and inhibiting phosphatidylinositol 3-kinase/Akt pathway activation. / 27.10.2020 / PubMed / Full text
Isoparvifuran isolated from Dalbergia odorifera attenuates H O -induced senescence of BJ cells through SIRT1 activation and AKT/mTOR pathway inhibition. / 30.09.2020 / PubMed / Full text
SIRT1 Is the Target Gene for 2,3,5,4'-Tetrahydroxystilbene-2-O-β-D-Glucoside Alleviating the HUVEC Senescence. / 2020 / PubMed / Full text
The Role of Sirtuins in Kidney Diseases. / 12.09.2020 / PubMed / Full text
The effect of 12-week resistance exercise training on serum levels of cellular aging process parameters in elderly men. / 11.2020 / PubMed / Full text
Virus-Induced Asthma Exacerbations: SIRT1 Targeted Approach. / 13.08.2020 / PubMed / Full text
Novel resveratrol derivatives have diverse effects on the survival, proliferation and senescence of primary human fibroblasts. / 12.2020 / PubMed / Full text
Glucose restriction delays senescence and promotes proliferation of HUVECs via the AMPK/SIRT1-FOXA3-Beclin1 pathway. / 01.10.2020 / PubMed / Full text
Therapeutic Effects of SRT2104 on Lung Injury in Rats with Emphysema via Reduction of Type II Alveolar Epithelial Cell Senescence. / 08.2020 / PubMed / Full text
Latifolin Inhibits Oxidative Stress-Induced Senescence via Upregulation of SIRT1 in Human Dermal Fibroblasts. / 01.07.2020 / PubMed / Full text
SRT1720-induced activation of SIRT1 alleviates vascular smooth muscle cell senescence through PKA-dependent phosphorylation of AMPKα at Ser485. / 07.2020 / PubMed / Full text
miR-128 plays a critical role in murine osteoclastogenesis and estrogen deficiency-induced bone loss. / 2020 / PubMed / Full text
Lymphocyte senescence in COPD is associated with decreased sirtuin 1 expression in steroid resistant pro-inflammatory lymphocytes. / 01-12.2020 / PubMed / Full text
Therapeutic effects of hydro-alcoholic leaf extract of Withania somnifera on age-induced changes in daily rhythms of Sirt1, Nrf2 and Rev-erbα in the SCN of male Wistar rats. / 10.2020 / PubMed / Full text
The Serum Concentration of Anti-Aging Proteins, Sirtuin1 and αKlotho in Patients with End-Stage Kidney Disease on Maintenance Hemodialysis. / 2020 / PubMed / Full text
Small extracellular vesicles deliver miR-21 and miR-217 as pro-senescence effectors to endothelial cells. / 2020 / PubMed / Full text
Spatiotemporal gating of SIRT1 functions by O-GlcNAcylation is essential for liver metabolic switching and prevents hyperglycemia. / 24.03.2020 / PubMed / Full text
Hydrogen Sulfide Inhibits Homocysteine-Induced Neuronal Senescence by Up-Regulation of SIRT1. / 2020 / PubMed / Full text
SIRT1 and aging related signaling pathways. / 04.2020 / PubMed / Full text
Tropisetron protects against brain aging via attenuating oxidative stress, apoptosis and inflammation: The role of SIRT1 signaling. / 01.05.2020 / PubMed / Full text
Nicotinamide mononucleotide (NMN) supplementation promotes neurovascular rejuvenation in aged mice: transcriptional footprint of SIRT1 activation, mitochondrial protection, anti-inflammatory, and anti-apoptotic effects. / 04.2020 / PubMed / Full text
Deacetylation of MRTF-A by SIRT1 defies senescence induced down-regulation of collagen type I in fibroblast cells. / 01.05.2020 / PubMed / Full text
Chronic Polyphenon-60 or Catechin Treatments Increase Brain Monoamines Syntheses and Hippocampal SIRT1 Levels Improving Cognition in Aged Rats. / 26.01.2020 / PubMed / Full text
Duck Oil-loaded Nanoemulsion Inhibits Senescence of Angiotensin II-treated Vascular Smooth Muscle Cells by Upregulating SIRT1. / 01.2020 / PubMed / Full text
Two novel SIRT1 activators, SCIC2 and SCIC2.1, enhance SIRT1-mediated effects in stress response and senescence. / 06-07.2020 / PubMed / Full text
Hydrogen sulfide attenuates mitochondrial dysfunction-induced cellular senescence and apoptosis in alveolar epithelial cells by upregulating sirtuin 1. / 23.12.2019 / PubMed / Full text
The protective role of omentin-1 in IL-1β-induced chondrocyte senescence. / 12.2020 / PubMed / Full text
The Lifespan Extension Ability of Nicotinic Acid Depends on Whether the Intracellular NAD Level Is Lower than the Sirtuin-Saturating Concentrations. / 24.12.2019 / PubMed / Full text
Alpha-mangostin decreased cellular senescence in human umbilical vein endothelial cells. / 06.2020 / PubMed / Full text
Central nervous system SIRT1 expression is required for cued and contextual fear conditioning memory responses in aging mice. / 23.09.2019 / PubMed / Full text
Does education level protect us from rapid ageing? Sirtuin expression versus age and level of education. / 10.2019 / PubMed
CO ameliorates endothelial senescence induced by 5-fluorouracil through SIRT1 activation. / 30.11.2019 / PubMed / Full text
Long noncoding RNA GAS5 inhibits cell proliferation and fibrosis in diabetic nephropathy by sponging miR-221 and modulating SIRT1 expression. / 20.10.2019 / PubMed / Full text
The Role of Sirtuin1 in Regulating Endothelial Function, Arterial Remodeling and Vascular Aging. / 2019 / PubMed / Full text
Deacetylation of LAMP1 drives lipophagy-dependent generation of free fatty acids by Abrus agglutinin to promote senescence in prostate cancer. / 03.2020 / PubMed / Full text
Plasma exosomes in OSA patients promote endothelial senescence: effect of long-term adherent continuous positive airway pressure. / 13.02.2020 / PubMed / Full text
Hydrogen Sulfide Inhibits High Glucose-Induced Neuronal Senescence by Improving Autophagic Flux [i]via[/i] Up-regulation of SIRT1. / 2019 / PubMed / Full text
Activation of the miR-34a-Mediated SIRT1/mTOR Signaling Pathway by Urolithin A Attenuates D-Galactose-Induced Brain Aging in Mice. / 10.2019 / PubMed / Full text

RPE

Transcriptomic Profiling of Human Pluripotent Stem Cell-derived Retinal Pigment Epithelium over Time. / 08.12.2020 / PubMed / Full text
Relationship between Oxygen Uptake, Heart Rate, and Perceived Effort in an Aquatic Incremental Test in Older Women. / 11.11.2020 / PubMed / Full text
Photoreceptor Degeneration in Homozygous Male Per2 Mice During Aging. / 02.11.2020 / PubMed / Full text
An In-Vitro Cell Model of Intracellular Protein Aggregation Provides Insights into RPE Stress Associated with Retinopathy. / 11.09.2020 / PubMed / Full text
Short-Term Effect of Self-Selected Training Intensity on Ambulatory Blood Pressure in Hypertensive Older Women: A Randomized Controlled Trial. / 2020 / PubMed / Full text
Correlation between brain volume and retinal photoreceptor outer segment volume in normal aging and neurodegenerative diseases. / 2020 / PubMed / Full text
Oxidative stress in the retina and retinal pigment epithelium (RPE): Role of aging, and DJ-1. / 17.07.2020 / PubMed / Full text
Direct-Coupled Electroretinogram (DC-ERG) for Recording the Light-Evoked Electrical Responses of the Mouse Retinal Pigment Epithelium. / 14.07.2020 / PubMed / Full text
High-density lipoproteins are a potential therapeutic target for age-related macular degeneration. / 25.09.2020 / PubMed / Full text
MTOR-initiated metabolic switch and degeneration in the retinal pigment epithelium. / 09.2020 / PubMed / Full text
[i]Lactobacillus paracasei[/i] KW3110 Suppresses Inflammatory Stress-Induced Premature Cellular Senescence of Human Retinal Pigment Epithelium Cells and Reduces Ocular Disorders in Healthy Humans. / 18.07.2020 / PubMed / Full text
Retinal pigment epithelium transcriptome analysis in chronic smoking reveals a suppressed innate immune response and activation of differentiation pathways. / 20.08.2020 / PubMed / Full text
Differences in Intraretinal Pigment Migration Across Inherited Retinal Dystrophies. / 09.2020 / PubMed / Full text
Exosomal MiRNA Transfer between Retinal Microglia and RPE. / 17.05.2020 / PubMed / Full text
Functionally validated imaging endpoints in the Alabama study on early age-related macular degeneration 2 (ALSTAR2): design and methods. / 19.05.2020 / PubMed / Full text
Mechanisms of mitochondrial dysfunction and their impact on age-related macular degeneration. / 13.04.2020 / PubMed / Full text
CSF1R blockade induces macrophage ablation and results in mouse choroidal vascular atrophy and RPE disorganization. / 01.04.2020 / PubMed / Full text
Extracellular microparticles exacerbate oxidative damage to retinal pigment epithelial cells. / 01.05.2020 / PubMed / Full text
Water-based continuous and interval training in older women: Cardiorespiratory and neuromuscular outcomes (WATER study). / 05.03.2020 / PubMed / Full text
Retrieval Practice Improves Recollection-Based Memory Over a Seven-Day Period in Younger and Older Adults. / 2019 / PubMed / Full text
A Comparison of Heart Rate Training Load and Perceptual Effort Between Masters and Young Cyclists / 01.05.2020 / PubMed / Full text
Retinal Pigment Epithelial Cells: The Unveiled Component in the Etiology of Prpf Splicing Factor-Associated Retinitis Pigmentosa. / 2019 / PubMed / Full text
AMPK May Play an Important Role in the Retinal Metabolic Ecosystem. / 2019 / PubMed / Full text
Stem cell-derived retinal pigment epithelium from patients with age-related macular degeneration exhibit reduced metabolism and matrix interactions. / 03.2020 / PubMed / Full text
Elovanoids counteract oligomeric β-amyloid-induced gene expression and protect photoreceptors. / 26.11.2019 / PubMed / Full text
Genetic LAMP2 deficiency accelerates the age-associated formation of basal laminar deposits in the retina. / 19.11.2019 / PubMed / Full text
Age, lipofuscin and melanin oxidation affect fundus near-infrared autofluorescence. / 10.2019 / PubMed / Full text
Relevance of working memory for reinforcement learning in older adults varies with timescale of learning. / 09.2020 / PubMed / Full text
Expression and Function of Mas-Related G Protein-Coupled Receptor D and Its Ligand Alamandine in Retina. / 01.2020 / PubMed / Full text

CRP

Omega-3 supplementation improves isometric strength but not muscle anabolic and catabolic signaling in response to resistance exercise in healthy older adults. / 07.12.2020 / PubMed / Full text
Circulating angiopoietin-like protein 2 levels and arterial stiffness in patients receiving maintenance hemodialysis: A cross-sectional study. / 02.11.2020 / PubMed / Full text
Cardiovascular rehabilitation in patients aged 70-year-old or older: benefits on functional capacity, physical activity and metabolic profile in younger [i]vs[/i]. older patients. / 28.09.2020 / PubMed / Full text
rRT-PCR Results of a Covid-19 Diagnosed Geriatric Patient. / 17.10.2020 / PubMed / Full text
The Association of Aging Biomarkers, Interstitial Lung Abnormalities, and Mortality. / 20.10.2020 / PubMed / Full text
A Novel Fortified Dairy Product and Sarcopenia Measures in Sarcopenic Older Adults: A Double-Blind Randomized Controlled Trial. / 13.10.2020 / PubMed / Full text
Age-Related Colonic Mucosal Microbiome Community Shifts in Monkeys. / 06.10.2020 / PubMed / Full text
The relationship between frailty and serum alpha klotho levels in geriatric patients. / 08.08.2020 / PubMed / Full text
ZMPSTE24 Is Associated with Elevated Inflammation and Progerin mRNA. / 28.08.2020 / PubMed / Full text
Cultural and life style practices associated with low inflammatory physiology in Japanese adults. / 11.2020 / PubMed / Full text
Moderate- to high intensity aerobic and resistance exercise reduces peripheral blood regulatory cell populations in older adults with rheumatoid arthritis. / 2020 / PubMed / Full text
PTSD and the klotho longevity gene: Evaluation of longitudinal effects on inflammation via DNA methylation. / 07.2020 / PubMed / Full text
Bereavement is associated with reduced systemic inflammation: C-reactive protein before and after widowhood. / 08.2020 / PubMed / Full text
The Impact of Age on the Prevalence of Sarcopenic Obesity in Bariatric Surgery Candidates. / 06.2020 / PubMed / Full text
Intake of dietary advanced glycation end products influences inflammatory markers, immune phenotypes, and antiradical capacity of healthy elderly in a little-studied population. / 02.2020 / PubMed / Full text
Intentional Switching Between Bimanual Coordination Patterns in Older Adults: Is It Mediated by Inhibition Processes? / 2020 / PubMed / Full text
Shorter Telomere Length in Peripheral Blood Leukocytes Is Associated with Post-Traumatic Chronic Osteomyelitis. / 11.2020 / PubMed / Full text
Risk Factors of Progression to Frailty: Findings from the Singapore Longitudinal Ageing Study. / 2020 / PubMed / Full text
Physical Function and Strength in Relation to Inflammation in Older Adults with Obesity and Increased Cardiometabolic Risk. / 2019 / PubMed / Full text
Key diagnostic characteristics of fever of unknown origin in Japanese patients: a prospective multicentre study. / 19.11.2019 / PubMed / Full text
Decrease in Serum Vitamin D Level of Older Patients with Fatigue. / 20.10.2019 / PubMed / Full text
The Association between Frailty Indicators and Blood-Based Biomarkers in Early-Old Community Dwellers of Thailand. / 17.09.2019 / PubMed / Full text
Associations of C-reactive protein and homocysteine concentrations with the impairment of intrinsic capacity domains over a 5-year follow-up among community-dwelling older adults at risk of cognitive decline (MAPT Study). / 11.2019 / PubMed / Full text
Longitudinal analysis of loneliness and inflammation at older ages: English longitudinal study of ageing. / 12.2019 / PubMed / Full text
The cortisol burden in elderly subjects with metabolic syndrome and its association with low-grade inflammation. / 07.2020 / PubMed / Full text
Recurrent circadian fasting (RCF) improves blood pressure, biomarkers of cardiometabolic risk and regulates inflammation in men. / 19.08.2019 / PubMed / Full text
Characteristics of patients with rheumatoid arthritis undergoing primary total joint replacement: A 14-year trend analysis (2004-2017). / 07.2020 / PubMed / Full text

CA1

The relation between tau pathology and granulovacuolar degeneration of neurons. / 01.2021 / PubMed / Full text
Memory and dendritic spines loss, and dynamic dendritic spines changes are age-dependent in the rat. / 12.2020 / PubMed / Full text
Deregulated expression of a longevity gene, Klotho, in the C9orf72 deletion mice with impaired synaptic plasticity and adult hippocampal neurogenesis. / 04.09.2020 / PubMed / Full text
COX5A Plays a Vital Role in Memory Impairment Associated With Brain Aging [i]via[/i] the BDNF/ERK1/2 Signaling Pathway. / 2020 / PubMed / Full text
Changes of fat-mass and obesity-associated protein expression in the hippocampus in animal models of high-fat diet-induced obesity and D-galactose-induced aging. / 2020 / PubMed / Full text
Phenylbutyrate ameliorates prefrontal cortex, hippocampus, and nucleus accumbens neural atrophy as well as synaptophysin and GFAP stress in aging mice. / 11.2020 / PubMed / Full text
Heterogeneity in brain distribution of activated microglia and astrocytes in a rat ischemic model of Alzheimer's disease after 2 years of survival. / 05.06.2020 / PubMed / Full text
Hippocampal Subregion Transcriptomic Profiles Reflect Strategy Selection during Cognitive Aging. / 17.06.2020 / PubMed / Full text
Associations between pattern separation and hippocampal subfield structure and function vary along the lifespan: A 7 T imaging study. / 05.05.2020 / PubMed / Full text
Laminarin Pretreatment Provides Neuroprotection against Forebrain Ischemia/Reperfusion Injury by Reducing Oxidative Stress and Neuroinflammation in Aged Gerbils. / 15.04.2020 / PubMed / Full text
Age-dependent Alteration in Mitochondrial Dynamics and Autophagy in Hippocampal Neuron of Cannabinoid CB1 Receptor-deficient Mice. / 07.2020 / PubMed / Full text
Functional Connectivity of Hippocampal CA3 Predicts Neurocognitive Aging via CA1-Frontal Circuit. / 30.06.2020 / PubMed / Full text
Integration of qRT-PCR and Immunohistochemical Techniques for mRNA Expression and Localization of m1AChR in the Brain of Aging Rat. / 2020 / PubMed / Full text
Role of Eclipta prostrata extract in improving spatial learning and memory deficits in D-galactose-induced aging in rats. / 10.2019 / PubMed
Differential annualized rates of hippocampal subfields atrophy in aging and future Alzheimer's clinical syndrome. / 06.2020 / PubMed / Full text
Rectification of radiotherapy-induced cognitive impairments in aged mice by reconstituted Sca-1 stem cells from young donors. / 07.02.2020 / PubMed / Full text
Increasing neurogenesis refines hippocampal activity rejuvenating navigational learning strategies and contextual memory throughout life. / 09.01.2020 / PubMed / Full text
Memory Performance Correlates of Hippocampal Subfield Volume in Mild Cognitive Impairment Subtype. / 2019 / PubMed / Full text
Spermidine protects from age-related synaptic alterations at hippocampal mossy fiber-CA3 synapses. / 23.12.2019 / PubMed / Full text
Methylene blue inhibits Caspase-6 activity, and reverses Caspase-6-induced cognitive impairment and neuroinflammation in aged mice. / 16.12.2019 / PubMed / Full text
Long-term Memory Upscales Volume of Postsynaptic Densities in the Process that Requires Autophosphorylation of αCaMKII. / 14.04.2020 / PubMed / Full text
PACAP27 mitigates an age-dependent hippocampal vulnerability to PGJ2-induced spatial learning deficits and neuroinflammation in mice. / 01.2020 / PubMed / Full text
Inhibition of oxidative stress by testosterone improves synaptic plasticity in senescence accelerated mice. / 2019 / PubMed / Full text
Restored presynaptic synaptophysin and cholinergic inputs contribute to the protective effects of physical running on spatial memory in aged mice. / 12.2019 / PubMed / Full text
Senescent neurophysiology: Ca signaling from the membrane to the nucleus. / 10.2019 / PubMed / Full text

GC

Body Size and Cuticular Hydrocarbons as Larval Age Indicators in the Forensic Blow Fly, Chrysomya albiceps (Diptera: Calliphoridae). / 04.12.2020 / PubMed / Full text
Composition of peony petal fatty acids and flavonoids and their effect on Caenorhabditis elegans lifespan. / 10.2020 / PubMed / Full text
Photo aging and fragmentation of polypropylene food packaging materials in artificial seawater. / 01.01.2021 / PubMed / Full text
Secretory galectin-3 induced by glucocorticoid stress triggers stemness exhaustion of hepatic progenitor cells. / 04.12.2020 / PubMed / Full text
Optimization of Ethanol Detection by Automatic Headspace Method for Cellulose Insulation Aging of Oil-immersed Transformers. / 15.07.2020 / PubMed / Full text
Sensory, olfactometric and chemical characterization of the aroma potential of Garnacha and Tempranillo winemaking grapes. / 30.11.2020 / PubMed / Full text
Accelerated Cognitive Ageing in epilepsy: exploring the effective connectivity between resting-state networks and its relation to cognitive decline. / 06.2020 / PubMed / Full text
Characterization of Jinhua ham aroma profiles in specific to aging time by gas chromatography-ion mobility spectrometry (GC-IMS). / 10.2020 / PubMed / Full text
Quantitative Profiling of Lipid Species in Caenorhabditis elegans with Gas Chromatography-Mass Spectrometry. / 2020 / PubMed / Full text
Physicochemical characterization of a polysaccharide from Agrocybe aegirita and its anti-ageing activity. / 15.05.2020 / PubMed / Full text
Structural characteristics, antioxidant properties and antiaging activities of galactan produced by Mentha haplocalyx Briq. / 15.04.2020 / PubMed / Full text
Contribution of Volatile Odorous Terpenoid Compounds to Aged Cognac Spirits Aroma in a Context of Multicomponent Odor Mixtures. / 25.11.2020 / PubMed / Full text
Plasma Formate Is Greater in Fetal and Neonatal Rats Compared with Their Mothers. / 01.05.2020 / PubMed / Full text
Development of a new strategy for studying the aroma potential of winemaking grapes through the accelerated hydrolysis of phenolic and aromatic fractions (PAFs). / 01.2020 / PubMed / Full text
Compromised steady-state germinal center activity with age in nonhuman primates. / 02.2020 / PubMed / Full text
Endogenous Glucocorticoid Signaling in the Regulation of Bone and Marrow Adiposity: Lessons from Metabolism and Cross Talk in Other Tissues. / 12.2019 / PubMed / Full text
4,5-Diphenyl-2-methyl picolinate induces cellular senescence by accumulating DNA damage and activating associated signaling pathways in gastric cancer. / 01.12.2019 / PubMed / Full text
Relationship Between the Dose Administered, Target Tissue Dose, and Toxicity Level After Acute Oral Exposure to Bifenthrin and Tefluthrin in Young Adult Rats. / 01.12.2019 / PubMed / Full text
Sugar Beet Pectin Supplementation Did Not Alter Profiles of Fecal Microbiota and Exhaled Breath in Healthy Young Adults and Healthy Elderly. / 12.09.2019 / PubMed / Full text
Identification and analysis of new α- and β-hydroxy ketones related to the formation of 3-methyl-2,4-nonanedione in musts and red wines. / 01.02.2020 / PubMed / Full text
Neonatal T Follicular Helper Cells Are Lodged in a Pre-T Follicular Helper Stage Favoring Innate Over Adaptive Germinal Center Responses. / 2019 / PubMed / Full text
Identification of Dialkylpyrazines Off-Flavors in Oak Wood. / 11.09.2019 / PubMed / Full text
Metabolomics Coupled with Transcriptomics Approach Deciphering Age Relevance in Sepsis. / 08.2019 / PubMed / Full text

NLRP3

Innate and Adaptive Immunity in Aging and Longevity: The Foundation of Resilience. / 12.2020 / PubMed / Full text
TET2-Loss-of-Function-Driven Clonal Hematopoiesis Exacerbates Experimental Insulin Resistance in Aging and Obesity. / 27.10.2020 / PubMed / Full text
Repeated propofol exposure-induced neuronal damage and cognitive impairment in aged rats by activation of NF-κB pathway and NLRP3 inflammasome. / 01.01.2021 / PubMed / Full text
A Small Molecule Stabilizer of the MYC G4-Quadruplex Induces Endoplasmic Reticulum Stress, Senescence and Pyroptosis in Multiple Myeloma. / 13.10.2020 / PubMed / Full text
Interleukin-1β Drives Cellular Senescence of Rat Astrocytes Induced by Oligomerized Amyloid β Peptide and Oxidative Stress. / 2020 / PubMed / Full text
Mechanisms of NLRP3 priming in inflammaging and age related diseases. / 10.2020 / PubMed / Full text
Lamivudine Inhibits [i]Alu[/i] RNA-induced Retinal Pigment Epithelium Degeneration via Anti-inflammatory and Anti-senescence Activities. / 07.2020 / PubMed / Full text
The NLRP3 Inflammasome: Metabolic Regulation and Contribution to Inflammaging. / 30.07.2020 / PubMed / Full text
Aging aggravated liver ischemia and reperfusion injury by promoting STING-mediated NLRP3 activation in macrophages. / 08.2020 / PubMed / Full text
Targeting NLRP3 Inflammasome Reduces Age-Related Experimental Alveolar Bone Loss. / 10.2020 / PubMed / Full text
Korean Red Ginseng Suppresses the Expression of Oxidative Stress Response and NLRP3 Inflammasome Genes in Aged C57BL/6 Mouse Ovaries. / 22.04.2020 / PubMed / Full text
Cepharanthine promotes the effect of dexmedetomidine on the deposition of β-amyloid in the old age of the senile dementia rat model by regulating inflammasome expression. / 2019 / PubMed / Full text
Ginsenoside Rg1 ameliorates glomerular fibrosis during kidney aging by inhibiting NOX4 and NLRP3 inflammasome activation in SAMP8 mice. / 27.02.2020 / PubMed / Full text
Blockade of the NLRP3 inflammasome improves metabolic health and lifespan in obese mice. / 04.2020 / PubMed / Full text
Autophagy and NLRP3 inflammasome crosstalk in neuroinflammation in aged bovine brains. / 06.2020 / PubMed / Full text
NLRP3 Inflammasome Inhibition by MCC950 in Aged Mice Improves Health via Enhanced Autophagy and PPARα Activity. / 13.07.2020 / PubMed / Full text
NLRP3 inflammasome suppression improves longevity and prevents cardiac aging in male mice. / 01.2020 / PubMed / Full text
Reduced NRF2 expression suppresses endothelial progenitor cell function and induces senescence during aging. / 08.09.2019 / PubMed / Full text
Effect of Aging on Taurine Transporter (TauT) Expression in the Mouse Brain Cortex. / 2019 / PubMed / Full text

SCD

Cognitive training and brain stimulation in prodromal Alzheimer's disease (AD-Stim)-study protocol for a double-blind randomized controlled phase IIb (monocenter) trial. / 07.11.2020 / PubMed / Full text
Blood Pressure in Different Dementia Disorders, Mild Cognitive Impairment, and Subjective Cognitive Decline. / 2020 / PubMed / Full text
Known-Groups and Convergent Validity of the Telephone Rey Auditory Verbal Learning Test total Learning Scores for Distinguishing Between Older Adults With Amnestic Cognitive Impairment and Subjective Cognitive Decline. / 17.10.2020 / PubMed / Full text
Subjective cognitive decline as a predictor of future cognitive decline: a systematic review. / 07-09.2020 / PubMed / Full text
Geriatric assessment for older adults with sickle cell disease: protocol for a prospective cohort pilot study. / 2020 / PubMed / Full text
Prevalence and psychosocial correlates of subjectively perceived decline in five cognitive domains: Results from a population-based cohort study in Germany. / 08.06.2020 / PubMed / Full text
SC411 treatment can enhance survival in a mouse model of sickle cell disease. / 07.2020 / PubMed / Full text
DNA fragmentation of human spermatozoa: Simple assessment of single- and double-strand DNA breaks and their respective dynamic behavioral response. / 09.2020 / PubMed / Full text
Psychometric Cognitive Decline Precedes the Advent of Subjective Cognitive Decline in the Evolution of Alzheimer's Disease. / 2020 / PubMed / Full text
Serum alkaline phosphatase is elevated and inversely correlated with cognitive functions in subjective cognitive decline: results from the ReGAl 2.0 project. / 03.05.2020 / PubMed / Full text
Changes in Activity Participation Among Older Adults With Subjective Cognitive Decline or Objective Cognitive Deficits. / 2019 / PubMed / Full text
Age, gender and drug therapy influences on Tpeak-tend interval and on electrical risk score. / 03-04.2020 / PubMed / Full text
Comorbid Chronic Conditions Among Older Adults with Subjective Cognitive Decline, United States, 2015-2017. / 2020 / PubMed / Full text
Resting State BOLD Variability Is Linked to White Matter Vascular Burden in Healthy Aging but Not in Older Adults With Subjective Cognitive Decline. / 2019 / PubMed / Full text
Estimated Life Expectancy and Income of Patients With Sickle Cell Disease Compared With Those Without Sickle Cell Disease. / 01.11.2019 / PubMed / Full text
Does Empirically Derived Classification of Individuals with Subjective Cognitive Complaints Predict Dementia? / 07.11.2019 / PubMed / Full text
Spatiotemporal Oscillatory Patterns During Working Memory Maintenance in Mild Cognitive Impairment and Subjective Cognitive Decline. / 01.2020 / PubMed / Full text
Microstructural Correlates and Laterality Effect of Prospective Memory in Non-Demented Adults with Memory Complaints. / 2019 / PubMed / Full text

BDNF

Influence of [i]BDNF[/i] Genetic Polymorphisms in the Pathophysiology of Aging-related Diseases. / 12.2020 / PubMed / Full text
Moderators of the Impact of (Poly)Phenols Interventions on Psychomotor Functions and BDNF: Insights from Subgroup Analysis and Meta-Regression. / 19.09.2020 / PubMed / Full text
Astroglia-Derived BDNF and MSK-1 Mediate Experience- and Diet-Dependent Synaptic Plasticity. / 18.07.2020 / PubMed / Full text
BDNF reverses aging-related microglial activation. / 14.07.2020 / PubMed / Full text
High Supervised Resistance Training in Elderly Women: The Role of Supervision Ratio. / 2020 / PubMed / Full text
Metformin regulates astrocyte reactivity in Parkinson's disease and normal aging. / 15.09.2020 / PubMed / Full text
Aging-Induced Brain-Derived Neurotrophic Factor in Adipocyte Progenitors Contributes to Adipose Tissue Dysfunction. / 05.2020 / PubMed / Full text
The Role of BDNF on Aging-Modulation Markers. / 09.05.2020 / PubMed / Full text
Spermidine and spermine delay brain aging by inducing autophagy in SAMP8 mice. / 08.04.2020 / PubMed / Full text
Microglia senescence occurs in both substantia nigra and ventral tegmental area. / 11.2020 / PubMed / Full text
Towards an understanding of the physical activity-BDNF-cognition triumvirate: A review of associations and dosage. / 07.2020 / PubMed / Full text
Impact of BDNF and sex on maintaining intact memory function in early midlife. / 04.2020 / PubMed / Full text
Testosterone replacement causes dose-dependent improvements in spatial memory among aged male rats. / 03.2020 / PubMed / Full text
The effects of aerobic exercise intensity on memory in older adults. / 06.2020 / PubMed / Full text
Protective effects of vitamin D on neurophysiologic alterations in brain aging: role of brain-derived neurotrophic factor (BDNF). / 16.09.2019 / PubMed / Full text
Differential Effects of Physical Exercise, Cognitive Training, and Mindfulness Practice on Serum BDNF Levels in Healthy Older Adults: A Randomized Controlled Intervention Study. / 2019 / PubMed / Full text
Dietary Supplementation with Fish Oil or Conjugated Linoleic Acid Relieves Depression Markers in Mice by Modulation of the Nrf2 Pathway. / 11.2019 / PubMed / Full text

TERT

Telomeres and telomerase in risk assessment of cardiovascular diseases. / 15.12.2020 / PubMed / Full text
A 4-Base-Pair Core-Enclosing Helix in Telomerase RNA Is Essential for Activity and for Binding to the Telomerase Reverse Transcriptase Catalytic Protein Subunit. / 20.11.2020 / PubMed / Full text
Angiotensin inhibition and cellular senescence in the developing rat kidney. / 12.2020 / PubMed / Full text
Decreased expression of TERT and telomeric proteins as human ovaries age may cause telomere shortening. / 27.08.2020 / PubMed / Full text
The secrets of telomerase: Retrospective analysis and future prospects. / 15.09.2020 / PubMed / Full text
Gene expression in human mesenchymal stem cell aging cultures: modulation by short peptides. / 06.2020 / PubMed / Full text
Unravelling Cellular Mechanisms of Stem Cell Senescence: An Aid from Natural Bioactive Molecules. / 20.03.2020 / PubMed / Full text
Expression of telomerase reverse transcriptase positively correlates with duration of lithium treatment in bipolar disorder. / 04.2020 / PubMed / Full text
FAM96B inhibits the senescence of dental pulp stem cells. / 05.2020 / PubMed / Full text
Aging and biomarkers: Transcriptional levels evaluation of Osteopontin/miRNA-181a axis in hepatic tissue of rats in different age ranges. / 05.2020 / PubMed / Full text
Resveratrol inhibits adipocyte differentiation and cellular senescence of human bone marrow stromal stem cells. / 04.2020 / PubMed / Full text
Characterization of human telomerase reverse transcriptase immortalized anterior cruciate ligament cell lines. / 12.2019 / PubMed / Full text
Mitochondria, Telomeres and Telomerase Subunits. / 2019 / PubMed / Full text
Towards Therapeutic Alternatives for Mercury Neurotoxicity in the Amazon: Unraveling the Pre-Clinical Effects of the Superfruit Açaí ([i]Euterpe oleracea[/i], Mart.) as Juice for Human Consumption. / 26.10.2019 / PubMed / Full text
Replication Stress at Telomeric and Mitochondrial DNA: Common Origins and Consequences on Ageing. / 08.10.2019 / PubMed / Full text
Telomerase Biology Associations Offer Keys to Cancer and Aging Therapeutics. / 2020 / PubMed / Full text
Transient induction of telomerase expression mediates senescence and reduces tumorigenesis in primary fibroblasts. / 17.09.2019 / PubMed / Full text

PGC

The Aging Stress Response and Its Implication for AMD Pathogenesis. / 22.11.2020 / PubMed / Full text
Constitutive PGC-1α Overexpression in Skeletal Muscle Does Not Contribute to Exercise-Induced Neurogenesis. / 16.11.2020 / PubMed / Full text
Dysregulated Autophagy Mediates Sarcopenic Obesity and Its Complications via AMPK and PGC1α Signaling Pathways: Potential Involvement of Gut Dysbiosis as a Pathological Link. / 19.09.2020 / PubMed / Full text
Resemblance and differences in dietary restriction nephroprotective mechanisms in young and old rats. / 24.09.2020 / PubMed / Full text
Acute and chronic effects of resistance training on skeletal muscle markers of mitochondrial remodeling in older adults. / 08.2020 / PubMed / Full text
PGC-1α-mediated regulation of mitochondrial function and physiological implications. / 09.2020 / PubMed / Full text
Targeting Mitochondrial Network Architecture in Down Syndrome and Aging. / 29.04.2020 / PubMed / Full text
Colchicine treatment impairs skeletal muscle mitochondrial function and insulin sensitivity in an age-specific manner. / 06.2020 / PubMed / Full text
A novel dipeptide from potato protein hydrolysate augments the effects of exercise training against high-fat diet-induced damages in senescence-accelerated mouse-prone 8 by boosting pAMPK / SIRT1/ PGC-1α/ pFOXO3 pathway. / 26.04.2020 / PubMed / Full text
Mitochondrial nucleoid remodeling and biogenesis are regulated by the p53-p21 -PKCζ pathway in p16 -silenced cells. / 24.04.2020 / PubMed / Full text
[Metabolic Alteration in Aging Process: Metabolic Remodeling in White Adipose Tissue by Caloric Restriction]. / 2020 / PubMed / Full text
Kynurenine aminotransferase isoforms display fiber-type specific expression in young and old human skeletal muscle. / 15.02.2020 / PubMed / Full text
Ubiquinol-10 delays postovulatory oocyte aging by improving mitochondrial renewal in pigs. / 20.01.2020 / PubMed / Full text
Mitochondrial oxidative capacity and NAD biosynthesis are reduced in human sarcopenia across ethnicities. / 20.12.2019 / PubMed / Full text
MicroRNA-34a (miR-34a) Mediates Retinal Endothelial Cell Premature Senescence through Mitochondrial Dysfunction and Loss of Antioxidant Activities. / 22.08.2019 / PubMed / Full text
Constitutive PGC-1α overexpression in skeletal muscle does not protect from age-dependent decline in neurogenesis. / 23.08.2019 / PubMed / Full text

CD28

Premature CD4 T Cells Senescence Induced by Chronic Infection in Patients with Acute Coronary Syndrome. / 12.2020 / PubMed / Full text
The IMMENSE Study: The Interplay Between iMMune and ENdothelial Cells in Mediating Cardiovascular Risk in Systemic Lupus Erythematosus. / 2020 / PubMed / Full text
Emergence of T cell immunosenescence in diabetic chronic kidney disease. / 2020 / PubMed / Full text
The relationship between Chlamydia pneumoniae infection and CD4/CD8 ratio, lymphocyte subsets in middle-aged and elderly individuals. / 12.2020 / PubMed / Full text
Next steps in mechanisms of inflammaging. / 22.09.2020 / PubMed / Full text
A randomized pilot trial to evaluate the benefit of the concomitant use of atorvastatin and Raltegravir on immunological markers in protease-inhibitor-treated subjects living with HIV. / 2020 / PubMed / Full text
Aging affects responsiveness of peripheral blood mononuclear cells to immunosuppression of periodontal ligament stem cells. / 07.2020 / PubMed / Full text
Comparison of Donepezil, Memantine, Melatonin, and Liuwei Dihuang Decoction on Behavioral and Immune Endocrine Responses of Aged Senescence-Accelerated Mouse Resistant 1 Mice. / 2020 / PubMed / Full text
Immunosenescent characteristics of T cells in young patients following haploidentical haematopoietic stem cell transplantation from parental donors. / 04.2020 / PubMed / Full text
Diagnosis-independent loss of T-cell costimulatory molecules in individuals with cytomegalovirus infection. / 07.2020 / PubMed / Full text
Accelerated immunosenescence in rheumatoid arthritis: impact on clinical progression. / 2020 / PubMed / Full text
Accelerated immune aging was correlated with lupus-associated brain fog in reproductive-age systemic lupus erythematosus patients. / 05.2020 / PubMed / Full text
T cells, aging and senescence. / 22.02.2020 / PubMed / Full text
Liver fibrosis and accelerated immune dysfunction (immunosenescence) among HIV-infected Russians with heavy alcohol consumption - an observational cross-sectional study. / 31.12.2019 / PubMed / Full text
Effect of Allogenic Bone Marrow Mesenchymal Stem Cell Transplantation on T Cells of Old Mice. / 02.2020 / PubMed / Full text
Peripheral antibody concentrations are associated with highly differentiated T cells and inflammatory processes in the human bone marrow. / 2019 / PubMed / Full text

HGS

Handgrip strength asymmetry is associated with future falls in older Americans. / 27.11.2020 / PubMed / Full text
Examining Additional Aspects of Muscle Function with a Digital Handgrip Dynamometer and Accelerometer in Older Adults: A Pilot Study. / 31.10.2020 / PubMed / Full text
The Relationship between Muscular Strength and Depression in Older Adults with Chronic Disease Comorbidity. / 18.09.2020 / PubMed / Full text
Handgrip Strength in the Korean Population: Normative Data and Cutoff Values. / 12.2019 / PubMed / Full text
Handgrip Strength Asymmetry and Weakness Are Associated with Lower Cognitive Function: A Panel Study. / 09.2020 / PubMed / Full text
Handgrip Strength Asymmetry and Weakness are Differentially Associated with Functional Limitations in Older Americans. / 06.05.2020 / PubMed / Full text
Absolute and Body Mass Index Normalized Handgrip Strength Percentiles by Gender, Ethnicity, and Hand Dominance in Americans. / 2020 / PubMed / Full text
Hand grip strength variability during serial testing as an entropic biomarker of aging: a Poincaré plot analysis. / 13.01.2020 / PubMed / Full text
Physical Activity and Fitness in White- and Blue-Collar Retired Men. / 11-12.2019 / PubMed / Full text
Association between Hand Grip Strength and Self-Rated Health in Middle- and Old-Aged Korean Citizens. / 01.2020 / PubMed / Full text
Weakness May Have a Causal Association With Early Mortality in Older Americans: A Matched Cohort Analysis. / 05.2020 / PubMed / Full text
Associations Between Dietary Patterns and Handgrip Strength: The Korea National Health and Nutrition Examination Survey 2014-2016. / 08.2020 / PubMed / Full text
Effect of relative handgrip strength on cardiovascular disease among Korean adults aged 45 years and older: Results from the Korean Longitudinal Study of Aging (2006-2016). / 01-02.2020 / PubMed / Full text
Weakness and cognitive impairment are independently and jointly associated with functional decline in aging Americans. / 09.2020 / PubMed / Full text
Association of phase angle with sarcopenia and its components in physically active older women. / 08.2020 / PubMed / Full text

CS

Acute effect of bodyweight-based strength training on blood pressure of hypertensive older adults: A randomized crossover clinical trial. / 16.11.2020 / PubMed / Full text
Particle growth with photochemical age from new particle formation to haze in the winter of Beijing, China. / 20.01.2021 / PubMed / Full text
Effect of aging on stabilization of Cd and Ni by biochars and enzyme activities in a historically contaminated alkaline agricultural soil simulated with wet-dry and freeze-thaw cycling. / 27.10.2020 / PubMed / Full text
Cockayne syndrome proteins CSA and CSB maintain mitochondrial homeostasis through NAD signaling. / 09.11.2020 / PubMed / Full text
Vision Impairment and Participation in Cognitively Stimulating Activities: The Health ABC Study. / 25.07.2020 / PubMed / Full text
Suspension training vs. traditional resistance training: effects on muscle mass, strength and functional performance in older adults. / 10.2020 / PubMed / Full text
Generational Differences in the 10-year Incidence of Impaired Contrast Sensitivity. / 21.07.2020 / PubMed / Full text
Inducible aging in Hydra oligactis implicates sexual reproduction, loss of stem cells, and genome maintenance as major pathways. / 08.2020 / PubMed / Full text
Noradrenergic Responsiveness Supports Selective Attention across the Adult Lifespan. / 27.05.2020 / PubMed / Full text
Cellular senescence: from anti-cancer weapon to anti-aging target. / 03.2020 / PubMed / Full text
Extra-mitochondrial citrate synthase initiates calcium oscillation and suppresses age-dependent sperm dysfunction. / 04.2020 / PubMed / Full text
Pathogenesis of chronic obstructive pulmonary disease (COPD) induced by cigarette smoke. / 10.2019 / PubMed / Full text
Possible Role of Amyloid Cross-Seeding in Evolvability and Neurodegenerative Disease. / 2019 / PubMed / Full text
Targeting p16-induced senescence prevents cigarette smoke-induced emphysema by promoting IGF1/Akt1 signaling in mice. / 2019 / PubMed / Full text

ACE2

How Does SARS-CoV-2 Affect the Central Nervous System? A Working Hypothesis. / 2020 / PubMed / Full text
Bioinformatic characterization of angiotensin-converting enzyme 2, the entry receptor for SARS-CoV-2. / 2020 / PubMed / Full text
A mouse-adapted model of SARS-CoV-2 to test COVID-19 countermeasures. / 10.2020 / PubMed / Full text
COVID-19 and Senotherapeutics: Any Role for the Naturally-occurring Dipeptide Carnosine? / 07.2020 / PubMed / Full text
The dual impact of ACE2 in COVID-19 and ironical actions in geriatrics and pediatrics with possible therapeutic solutions. / 15.09.2020 / PubMed / Full text
The possible pathophysiology mechanism of cytokine storm in elderly adults with COVID-19 infection: the contribution of "inflame-aging". / 09.2020 / PubMed / Full text
Decoding SARS-CoV-2 hijacking of host mitochondria in COVID-19 pathogenesis. / 01.08.2020 / PubMed / Full text
A Mouse Model of SARS-CoV-2 Infection and Pathogenesis. / 08.07.2020 / PubMed / Full text
COVID-19-associated cardiovascular morbidity in older adults: a position paper from the Italian Society of Cardiovascular Researches. / 08.2020 / PubMed / Full text
Gut microbiota and Covid-19- possible link and implications. / 08.2020 / PubMed / Full text
Inflamm-aging: Why older men are the most susceptible to SARS-CoV-2 complicated outcomes. / 06.2020 / PubMed / Full text
Restoration of the Renin-Angiotensin System Balance Is a Part of the Effect of Fasting on Cardiovascular Rejuvenation: Role of Age and Fasting Models. / 08.2020 / PubMed / Full text
Angiotensin 1-7 alleviates aging-associated muscle weakness and bone loss, but is not associated with accelerated aging in ACE2-knockout mice. / 30.09.2019 / PubMed / Full text

STAT3

Dietary Restriction Suppresses Steatosis-Associated Hepatic Tumorigenesis in Hepatitis C Virus Core Gene Transgenic Mice. / 09.2020 / PubMed / Full text
Skeletal glucocorticoid signalling determines leptin resistance and obesity in aging mice. / 12.2020 / PubMed / Full text
AMPK alleviates oxidative stress‑induced premature senescence via inhibition of NF-κB/STAT3 axis-mediated positive feedback loop. / 10.2020 / PubMed / Full text
Age-related loss of neural stem cell O-GlcNAc promotes a glial fate switch through STAT3 activation. / 08.09.2020 / PubMed / Full text
Cell Death by Gallotannin Is Associated with Inhibition of the JAK/STAT Pathway in Human Colon Cancer Cells. / 2020 / PubMed / Full text
The effect of interleukin 6 deficiency on myocardial signal transduction pathways activation induced by bacterial lipopolysaccharide in young and old mice. / 09.2020 / PubMed / Full text
Silibinin and SARS-CoV-2: Dual Targeting of Host Cytokine Storm and Virus Replication Machinery for Clinical Management of COVID-19 Patients. / 07.06.2020 / PubMed / Full text
Implication of JAK1/STAT3/SOCS3 Pathway in Aging of Cerebellum of Male Rat: Histological and Molecular study. / 01.06.2020 / PubMed / Full text
Atorvastatin-induced senescence of hepatocellular carcinoma is mediated by downregulation of hTERT through the suppression of the IL-6/STAT3 pathway. / 2020 / PubMed / Full text
Deciphering the Molecular Mechanism of Spontaneous Senescence in Primary Epithelial Ovarian Cancer Cells. / 27.01.2020 / PubMed / Full text
Persistent Activation of STAT3 Pathway in the Retina Induced Vision Impairment and Retinal Degenerative Changes in Ageing Mice. / 2019 / PubMed / Full text
Interleukin-10 induces senescence of activated hepatic stellate cells via STAT3-p53 pathway to attenuate liver fibrosis. / 02.2020 / PubMed / Full text

CP

A Life Course Perspective on Growing Older With Cerebral Palsy. / 19.11.2020 / PubMed / Full text
The molecular anatomy and functions of the choroid plexus in healthy and diseased brain. / 01.11.2020 / PubMed / Full text
The effects and mechanism of collagen peptide and elastin peptide on skin aging induced by D-galactose combined with ultraviolet radiation. / 09.2020 / PubMed / Full text
Model based strategies towards protein A resin lifetime optimization and supervision. / 16.08.2020 / PubMed / Full text
The influence of age and environmental conditions on supplement intake by beef cattle winter grazing northern mixed-grass rangelands. / 01.07.2020 / PubMed / Full text
Cyclophosphamide, a cancer chemotherapy drug-induced early onset of reproductive senescence and alterations in reproductive performance and their prevention in mice. / 15.06.2020 / PubMed / Full text
Asymptomatic [i]Clostridium perfringens[/i] Inhabitation in Intestine Can Cause Inflammation, Apoptosis, and Disorders in Brain. / 01.2020 / PubMed / Full text
The Role of the Clinical Pharmacist in the Management of People Living with HIV in the Modern Antiretroviral Era. / 2019 / PubMed / Full text
A clinically feasible method for the assessment and characterization of pain in patients with chronic pancreatitis. / 01.2020 / PubMed / Full text
Differences in geometric strength at the contralateral hip between men with hip fracture and non-fractured comparators. / 03.2020 / PubMed / Full text
Factors associated with the number of clinical pharmacy recommendations: findings from an observational study in geriatric inpatients. / 23.10.2019 / PubMed / Full text
Protection against oxidative stress and anti-aging effect in Drosophila of royal jelly-collagen peptide. / 01.2020 / PubMed / Full text

APP

Pre-symptomatic Caspase-1 inhibitor delays cognitive decline in a mouse model of Alzheimer disease and aging. / 11.09.2020 / PubMed / Full text
Regorafenib Regulates AD Pathology, Neuroinflammation, and Dendritic Spinogenesis in Cells and a Mouse Model of AD. / 09.07.2020 / PubMed / Full text
An agnostic reevaluation of the amyloid cascade hypothesis of Alzheimer's disease pathogenesis: The role of APP homeostasis. / 11.2020 / PubMed / Full text
Transcriptomic profiling of microglia and astrocytes throughout aging. / 01.04.2020 / PubMed / Full text
Platelets in Amyloidogenic Mice Are Activated and Invade the Brain. / 2020 / PubMed / Full text
CHIP modulates APP-induced autophagy-dependent pathological symptoms in Drosophila. / 02.2020 / PubMed / Full text
Studies on APP metabolism related to age-associated mitochondrial dysfunction in APP/PS1 transgenic mice. / 19.11.2019 / PubMed / Full text
Intermittent Hypoxia-Hyperoxia Training Improves Cognitive Function and Decreases Circulating Biomarkers of Alzheimer's Disease in Patients with Mild Cognitive Impairment: A Pilot Study. / 30.10.2019 / PubMed / Full text
The Implication of Androgens in the Presence of Protein Kinase C to Repair Alzheimer’s Disease-Induced Cognitive Dysfunction / 03.2020 / PubMed / Full text
Modulation of Neural and Muscular Adaptation Processes During Resistance Training by Fish Protein Ingestions in Older Adults. / 17.04.2020 / PubMed / Full text
Antipsychotic Polypharmacy in Older Adult Asian Patients With Schizophrenia: Research on Asian Psychotropic Prescription Pattern. / 11.2019 / PubMed / Full text
A pleiotropic role for exosomes loaded with the amyloid β precursor protein carboxyl-terminal fragments in the brain of Down syndrome patients. / 12.2019 / PubMed / Full text

ATM

SATMF Suppresses the Premature Senescence Phenotype of the ATM Loss-of-Function Mutant and Improves Its Fertility in [i]Arabidopsis[/i]. / 30.10.2020 / PubMed / Full text
ATM mediated-p53 signaling pathway forms a novel axis for senescence control. / 11.2020 / PubMed / Full text
Non-canonical ATM/MRN activities temporally define the senescence secretory program. / 05.10.2020 / PubMed / Full text
ATM is a key driver of NF-κB-dependent DNA-damage-induced senescence, stem cell dysfunction and aging. / 22.03.2020 / PubMed / Full text
ATM suppresses leaf senescence triggered by DNA double-strand break through epigenetic control of senescence-associated genes in Arabidopsis. / 07.2020 / PubMed / Full text
Glioblastoma Cells Do Not Affect Axitinib-Dependent Senescence of HUVECs in a Transwell Coculture Model. / 21.02.2020 / PubMed / Full text
Declining BRCA-Mediated DNA Repair in Sperm Aging and its Prevention by Sphingosine-1-Phosphate. / 03.2020 / PubMed / Full text
BRCA-related ATM-mediated DNA double-strand break repair and ovarian aging. / 01.01.2020 / PubMed / Full text
ATM Deficiency Accelerates DNA Damage, Telomere Erosion, and Premature T Cell Aging in HIV-Infected Individuals on Antiretroviral Therapy. / 2019 / PubMed / Full text
SMG1 heterozygosity exacerbates haematopoietic cancer development in Atm null mice by increasing persistent DNA damage and oxidative stress. / 12.2019 / PubMed / Full text
LncRNA RP11-670E13.6, interacted with hnRNPH, delays cellular senescence by sponging microRNA-663a in UVB damaged dermal fibroblasts. / 23.08.2019 / PubMed / Full text
Tel1/ATM Signaling to the Checkpoint Contributes to Replicative Senescence in the Absence of Telomerase. / 10.2019 / PubMed / Full text

GFAP

Immunohistological Detection of Active Satellite Cellsin Rat Dorsal Root Ganglia after Parenteral Administration of Lipopolysaccharide and during Aging. / 09.2020 / PubMed / Full text
Transgenic Mice Expressing Human α-Synuclein in Noradrenergic Neurons Develop Locus Ceruleus Pathology and Nonmotor Features of Parkinson's Disease. / 23.09.2020 / PubMed / Full text
ApoE Genotype-Dependent Response to Antioxidant and Exercise Interventions on Brain Function. / 25.06.2020 / PubMed / Full text
Age-Dependent Heterogeneity of Murine Olfactory Bulb Astrocytes. / 2020 / PubMed / Full text
Neuroinflammation in Aged Brain: Impact of the Oral Administration of Ellagic Acid Microdispersion. / 21.05.2020 / PubMed / Full text
Long-term treatment with spermidine increases health span of middle-aged Sprague-Dawley male rats. / 06.2020 / PubMed / Full text
Meta-analysis of human prefrontal cortex reveals activation of GFAP and decline of synaptic transmission in the aging brain. / 05.03.2020 / PubMed / Full text
Astroglial biotin deprivation under endoplasmic reticulum stress uncouples BCAA-mTORC1 role in lipid synthesis to prolong autophagy inhibition in the aging brain. / 09.2020 / PubMed / Full text
Long-lived mice with reduced growth hormone signaling have a constitutive upregulation of hepatic chaperone-mediated autophagy. / 12.02.2020 / PubMed / Full text
Lipopolysaccharide exposure during late embryogenesis triggers and drives Alzheimer-like behavioral and neuropathological changes in CD-1 mice. / 03.2020 / PubMed / Full text
Increased levels of Aβ42 decrease the lifespan of ob/ob mice with dysregulation of microglia and astrocytes. / 02.2020 / PubMed / Full text
Selective brain neuronal and glial losses without changes in GFAP immunoreactivity: Young versus mature adult Wistar rats. / 09.2019 / PubMed / Full text

CGA

Safety and efficacy of preoperative chemoradiotherapy in fit older patients with intermediate or locally advanced rectal cancer evaluated by comprehensive geriatric assessment: A planned interim analysis of a multicenter, phase II trial. / 04.11.2020 / PubMed / Full text
The Protective Effect of Chlorogenic Acid on Vascular Senescence via the Nrf2/HO-1 Pathway. / 25.06.2020 / PubMed / Full text
Association between comprehensive geriatric assessment and short-term outcomes among older adult patients with stroke: A nationwide retrospective cohort study using propensity score and instrumental variable methods. / 06.2020 / PubMed / Full text
Interventions to Improve Clinical Outcomes in Older Adults Admitted to a Surgical Service: A Systematic Review and Meta-analysis. / 12.2020 / PubMed / Full text
A Computerized Frailty Assessment Tool at Points-of-Care: Development of a Standalone Electronic Comprehensive Geriatric Assessment/Frailty Index (eFI-CGA). / 2020 / PubMed / Full text
Allocating patients to geriatric medicine wards in a tertiary university hospital in England: A service evaluation of the Specialist Advice for the Frail Elderly (SAFE) team. / 09.2018 / PubMed / Full text
Role of Frailty on Risk Stratification in Cardiac Surgery and Procedures. / 2020 / PubMed / Full text
Developing an objective structured clinical examination in comprehensive geriatric assessment - A pilot study. / 05-08.2019 / PubMed / Full text
How do doctors choose treatment for older gynecological cancer patients? A Japanese Gynecologic Oncology Group survey of gynecologic oncologists. / 04.2020 / PubMed / Full text
Validation of the Pictorial Fit-Frail Scale in a memory clinic setting. / 09.2020 / PubMed / Full text
Impact of Resolution of Hyponatremia on Neurocognitive and Motor Performance in Geriatric Patients. / 29.08.2019 / PubMed / Full text
Health outcome of older hospitalized patients in internal medicine environments evaluated by Identification of Seniors at Risk (ISAR) screening and geriatric assessment. / 14.08.2019 / PubMed / Full text

TH

Thyroid hormone signaling is associated with physical performance, muscle mass, and strength in a cohort of oldest-old: results from the Mugello study. / 21.11.2020 / PubMed / Full text
Social Environment Ameliorates Behavioral and Immune Impairments in Tyrosine Hydroxylase Haploinsufficient Female Mice. / 09.08.2020 / PubMed / Full text
Mechanism of thyroid hormone signaling in skeletal muscle of aging mice. / 27.07.2020 / PubMed / Full text
Longitudinal changes in bone mineral density and trabecular bone score in Korean adults: a community-based prospective study. / 03.07.2020 / PubMed / Full text
Quantitative proteomic profiling of the rat substantia nigra places glial fibrillary acidic protein at the hub of proteins dysregulated during aging: Implications for idiopathic Parkinson's disease. / 07.2020 / PubMed / Full text
Withaferin-A Protects the Nigral Dopamine Neuron and Recovers Motor Activity in Aged Rats. / 2019 / PubMed / Full text
Effects of physical activity on bone mineral density in older adults: Korea National Health and Nutrition Examination Survey, 2008-2011. / 26.10.2019 / PubMed / Full text
Age-Related Resistance to Thyroid Hormone Action. / 11.2019 / PubMed / Full text
Age-Dependent Changes in Glucose Homeostasis in Male Deiodinase Type 2 Knockout Zebrafish. / 01.11.2019 / PubMed / Full text
Age effect on thyroid hormone brain response in male mice. / 12.2019 / PubMed / Full text
Aging Is Associated with Low Thyroid State and Organ-Specific Sensitivity to Thyroxine. / 12.2019 / PubMed / Full text

SOD2

Astaxanthin Counteracts Vascular Calcification In Vitro Through an Early Up-Regulation of SOD2 Based on a Transcriptomic Approach. / 12.11.2020 / PubMed / Full text
Alginate Oligosaccharide Prevents against D-galactose-mediated Cataract in C57BL/6J Mice via Regulating Oxidative Stress and Antioxidant System. / 06.11.2020 / PubMed / Full text
Protoflavones in melanoma therapy: Prooxidant and pro-senescence effect of protoapigenone and its synthetic alkyl derivative in A375 cells. / 01.11.2020 / PubMed / Full text
Ginsenoside Rg1 protects against Sca-1 HSC/HPC cell aging by regulating the SIRT1-FOXO3 and SIRT3-SOD2 signaling pathways in a γ-ray irradiation-induced aging mice model. / 08.2020 / PubMed / Full text
Almond Skin Extracts and Chlorogenic Acid Delay Chronological Aging and Enhanced Oxidative Stress Response in Yeast. / 28.05.2020 / PubMed / Full text
Opposing p53 and mTOR/AKT promote an in vivo switch from apoptosis to senescence upon telomere shortening in zebrafish. / 19.05.2020 / PubMed / Full text
Bioactive peptides derived from crimson snapper and in vivo anti-aging effects on fat diet-induced high fat Drosophila melanogaster. / 29.01.2020 / PubMed / Full text
Ellagic acid prolongs the lifespan of Drosophila melanogaster. / 02.2020 / PubMed / Full text
Chlorella vulgaris modulates the expression of senescence-associated genes in replicative senescence of human diploid fibroblasts. / 01.2020 / PubMed / Full text
Age-Associated Changes in Antioxidants and Redox Proteins of Rat Heart. / 30.12.2019 / PubMed / Full text
Impact of curcumin on replicative and chronological aging in the Saccharomyces cerevisiae yeast. / 02.2020 / PubMed / Full text

MB

Probing menstrual bloodstain aging with fluorescence spectroscopy. / 13.11.2020 / PubMed / Full text
Effect of physical exercise and medication on enhancing cognitive function in older adults with vascular risk. / 11.2020 / PubMed / Full text
A novel indenone derivative selectively induces senescence in MDA-MB-231 (breast adenocarcinoma) cells. / 01.11.2020 / PubMed / Full text
Improved Autophagic Flux in Escapers from Doxorubicin-Induced Senescence/Polyploidy of Breast Cancer Cells. / 24.08.2020 / PubMed / Full text
Lifespan regulation in α/β posterior neurons of the fly mushroom bodies by Rab27. / 08.2020 / PubMed / Full text
Tailored Functionalized Magnetic Nanoparticles to Target Breast Cancer Cells Including Cancer Stem-Like Cells. / 29.05.2020 / PubMed / Full text
"Mitotic Slippage" and Extranuclear DNA in Cancer Chemoresistance: A Focus on Telomeres. / 16.04.2020 / PubMed / Full text
Diversity of the Senescence Phenotype of Cancer Cells Treated with Chemotherapeutic Agents. / 23.11.2019 / PubMed / Full text
Downregulation of the inflammatory network in senescent fibroblasts and aging tissues of the long-lived and cancer-resistant subterranean wild rodent, Spalax. / 01.2020 / PubMed / Full text
Quantification of the health-status of the Dutch Labrador retriever population. / 01.11.2019 / PubMed / Full text
Conjugated Physiological Resveratrol Metabolites Induce Senescence in Breast Cancer Cells: Role of p53/p21 and p16/Rb Pathways, and ABC Transporters. / 11.2019 / PubMed / Full text

PC

Blended home-based exercise and dietary protein in community-dwelling older adults: a cluster randomized controlled trial. / 26.10.2020 / PubMed / Full text
Right ventricular diastolic function in aging: a head-to-head comparison between phase-contrast MRI and Doppler echocardiography. / 27.09.2020 / PubMed / Full text
Pulse Width and Implantable Pulse Generator Longevity in Pallidal Deep Brain Stimulation for Dystonia: A Population-Based Comparative Effectiveness Study. / 2020 / PubMed / Full text
Gemcitabine plus nab-paclitaxel with initial dose reduction for older patients with advanced pancreatic cancer. / 20.06.2020 / PubMed / Full text
Protective effects of 17-β-oestradiol and phytoestrogen on age-induced oxidative stress and inhibition of surfactant synthesis in rat type II pneumocytes. / 02.2021 / PubMed / Full text
Pacing During 200-m Competitive Masters Swimming. / 07.2020 / PubMed / Full text
Prostate cancer in Pennsylvania: The role of older age at diagnosis, aggressiveness, and environmental risk factors on treatment and mortality using data from the Pennsylvania Cancer Registry. / 05.2020 / PubMed / Full text
Extracranial versus intracranial hydro-hemodynamics during aging: a PC-MRI pilot cross-sectional study. / 14.01.2020 / PubMed / Full text
Age-specific health-related quality of life in disease-free long-term prostate cancer survivors versus male population controls-results from a population-based study. / 06.2020 / PubMed / Full text
Cross-Linked Polyphenol-Based Drug Nano-Self-Assemblies Engineered to Blockade Prostate Cancer Senescence. / 23.10.2019 / PubMed / Full text
An Immersive Virtual Reality Platform for Assessing Spatial Navigation Memory in Predementia Screening: Feasibility and Usability Study. / 03.09.2019 / PubMed / Full text

Aging genes 10

CD4

TNF

HR

APOE

MSC

SIRT1

RPE

CRP

CA1

GC

NLRP3

SCD

BDNF

TERT

PGC

CD28

HGS

CS

ACE2

STAT3

CP

APP

ATM

GFAP

CGA

TH

SOD2

MB

PC

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