Protein transport protein Sec16B (Leucine zipper transcription regulator 2) (Regucalcin gene promoter region-related protein p117) (RGPR-p117) (SEC16 homolog B) [KIAA1928] [LZTR2] [RGPR] [SEC16S]
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Candidate gene association study of BMI-related loci, weight, and adiposity in old age.
Most genome-wide association studies are confined to middle-aged populations. It is unclear whether associations between single nucleotide polymorphisms (SNPs) and obesity persist in old age. We aimed to relate 10 body mass index (BMI)-associated SNPs to weight, BMI, % fat, visceral and subcutaneous adipose tissue in Health ABC and AGES-Reykjavik comprising 4,846 individuals of European Ancestry, and 1,139 African Americans over age 65. SNPs were scaled using effect estimates from candidate SNPs. In Health ABC, a SNP near GNPDA2 was modestly associated with weight and SAT area (p = .008, p = .001). Risk score (sum of scaled SNPs) was associated with weight, BMI, and SAT area (p < .0001 for all), but neither GNPDA2 nor risk score was associated with weight, BMI, visceral adippose tissue, subcutaneous adipose tissue, or % fat in AGES-Reykjavik. In African Americans, a SNP near SEC16B was weakly associated with weight (p = .04). In this sample of older adults, no BMI-associated SNPs were associated with weight or adiposity.
MeSH Terms
- Adiposity
- African Americans
- Aged
- Aged, 80 and over
- Aging
- Body Mass Index
- Body Weight
- European Continental Ancestry Group
- Female
- Gene Expression Regulation
- Genetic Loci
- Genetic Predisposition to Disease
- Genetic Testing
- Genome, Human
- Humans
- Male
- Obesity
- Overweight
- Phenotype
- Polymorphism, Single Nucleotide
- Prospective Studies
- Sampling Studies
- United States
Keywords
- Aging
- Genetics
- Obesity
- SNPs.
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Thirty new loci for age at menarche identified by a meta-analysis of genome-wide association studies.
To identify loci for age at menarche, we performed a meta-analysis of 32 genome-wide association studies in 87,802 women of European descent, with replication in up to 14,731 women. In addition to the known loci at LIN28B (P = 5.4 × 10⁻⁶⁰) and 9q31.2 (P = 2.2 × 10⁻³³), we identified 30 new menarche loci (all P < 5 × 10⁻⁸) and found suggestive evidence for a further 10 loci (P < 1.9 × 10⁻⁶). The new loci included four previously associated with body mass index (in or near FTO, SEC16B, TRA2B and TMEM18), three in or near other genes implicated in energy homeostasis (BSX, CRTC1 and MCHR2) and three in or near genes implicated in hormonal regulation (INHBA, PCSK2 and RXRG). Ingenuity and gene-set enrichment pathway analyses identified coenzyme A and fatty acid biosynthesis as biological processes related to menarche timing.
MeSH Terms
- Adolescent
- Aging
- Body Height
- Body Size
- Child
- DNA Copy Number Variations
- Female
- Genetic Loci
- Genetic Predisposition to Disease
- Genome-Wide Association Study
- Humans
- Inheritance Patterns
- Menarche
- Obesity
- Polymorphism, Single Nucleotide
- Quantitative Trait Loci
- Reproducibility of Results
- Time Factors