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MAP3K12-binding inhibitory protein 1 (MAPK upstream kinase-binding inhibitory protein) (MUK-binding inhibitory protein) [BM-015]


Long-term caloric restriction ameliorates the decline in diastolic function in humans.

We determined whether caloric restriction (CR) has cardiac-specific effects that attenuate the established aging-associated impairments in diastolic function (DF). Caloric restriction retards the aging process in small mammals; however, no information is available on the effects of long-term CR on human aging. In healthy individuals, Doppler echocardiography has established the pattern of aging-associated DF impairment, whereas little change is observed in systolic function (SF). Diastolic function was assessed in 25 subjects (age 53 /- 12 years) practicing CR for 6.5 /- 4.6 years and 25 age- and gender-matched control subjects consuming Western diets. Diastolic function was quantified by transmitral flow, Doppler tissue imaging, and model-based image processing (MBIP) of E waves. C-reactive protein (CRP), tumor necrosis factor-alpha (TNF-alpha), and transforming growth factor-beta1 (TGF-beta1) were also measured. No difference in SF was observed between groups; however, standard transmitral Doppler flow DF indexes of the CR group were similar to those of younger individuals, and MBIP-based, flow-derived DF indexes, reflecting chamber viscoelasticity and stiffness, were significantly lower than in control subjects. Blood pressure, serum CRP, TNF-alpha, and TGF-beta(1) levels were significantly lower in the CR group (102 /- 10/61 /- 7 mm Hg, 0.3 /- 0.3 mg/l, 0.8 /- 0.5 pg/ml, 29.4 /- 6.9 ng/ml, respectively) compared with the Western diet group (131 /- 11/83 /- 6 mm Hg, 1.9 /- 2.8 mg/l, 1.5 /- 1.0 pg/ml, 35.4 /- 7.1 ng/ml, respectively). Caloric restriction has cardiac-specific effects that ameliorate aging-associated changes in DF. These beneficial effects on cardiac function might be mediated by the effect of CR on blood pressure, systemic inflammation, and myocardial fibrosis.

MeSH Terms

  • Adult
  • Aged
  • Aged, 80 and over
  • Aging
  • C-Reactive Protein
  • Caloric Restriction
  • Cross-Sectional Studies
  • Diastole
  • Echocardiography, Doppler
  • Female
  • Humans
  • Image Processing, Computer-Assisted
  • Male
  • Middle Aged
  • Systole
  • Transforming Growth Factor beta
  • Transforming Growth Factor beta1
  • Tumor Necrosis Factor-alpha