Aging genes 3-9

ATG7

Age-related impairment of autophagy in cervical motor neurons. / 05.12.2020 / PubMed / Full text
Comprehensive Bioinformatics Identifies Key microRNA Players in ATG7-Deficient Lung Fibroblasts. / 09.06.2020 / PubMed / Full text
Regulation of autophagy by DNA G-quadruplexes. / 18.05.2020 / PubMed / Full text
ATG7 is essential for secretion of iron from ameloblasts and normal growth of murine incisors during aging. / 10.2020 / PubMed / Full text
Enhancing Autophagy Diminishes Aberrant Ca Homeostasis and Arrhythmogenesis in Aging Rabbit Hearts. / 2019 / PubMed / Full text
Adipose-Derived Stem/Stromal Cells Recapitulate Aging Biomarkers and Show Reduced Stem Cell Plasticity Affecting Their Adipogenic Differentiation Capacity. / 08.2019 / PubMed / Full text
Inhibition of glioma growth by flavokawain B is mediated through endoplasmic reticulum stress induced autophagy. / 2018 / PubMed / Full text
Carvacrol nanoemulsion evokes cell cycle arrest, apoptosis induction and autophagy inhibition in doxorubicin resistant-A549 cell line. / 2018 / PubMed / Full text
SIRT6 histone deacetylase functions as a potential oncogene in human melanoma. / 09.2017 / PubMed / Full text

BAX

Clearance of therapy-induced senescent tumor cells by the senolytic ABT-263 via interference with BCL-X -BAX interaction. / 10.2020 / PubMed / Full text
CREB Signaling Mediates Dose-Dependent Radiation Response in the Murine Hippocampus Two Years after Total Body Exposure. / 03.01.2020 / PubMed / Full text
Reduced sucrose nonfermenting AMPK-related kinase (SNARK) activity aggravates cancer-induced skeletal muscle wasting. / 09.2019 / PubMed / Full text
Modulated electro-hyperthermia induced p53 driven apoptosis and cell cycle arrest additively support doxorubicin chemotherapy of colorectal cancer in vitro. / 08.2019 / PubMed / Full text
The Clearance Effect of Tetrahedral DNA Nanostructures on Senescent Human Dermal Fibroblasts. / 16.01.2019 / PubMed / Full text
Premature placental aging in term small-for-gestational-age and growth-restricted fetuses. / 05.2019 / PubMed / Full text
Regulation of apoptosis and autophagy in mouse and human skeletal muscle with aging and lifelong exercise training. / 01.10.2018 / PubMed / Full text
Xanthohumol exerts protective effects in liver alterations associated with aging. / 03.2019 / PubMed / Full text
Protective effect of xanthohumol against age-related brain damage. / 11.2017 / PubMed / Full text

BRAF

Conditional reprograming culture conditions facilitate growth of lower grade glioma models. / 01.12.2020 / PubMed / Full text
Active notch protects MAPK activated melanoma cell lines from MEK inhibitor cobimetinib. / 14.11.2020 / PubMed / Full text
Mitochondrial metabolic reprograming via BRAF inhibition ameliorates senescence. / 15.10.2019 / PubMed / Full text
Deciphering the genotype and phenotype of hairy cell leukemia: clues for diagnosis and treatment. / 08.2019 / PubMed / Full text
A clinical trial of somatic and germline analyses for healthy longevity in a postoperative cancer patient. / 09.2019 / PubMed / Full text
Aging-like Spontaneous Epigenetic Silencing Facilitates Wnt Activation, Stemness, and Braf -Induced Tumorigenesis. / 11.02.2019 / PubMed / Full text
Acquired resistance to BRAFi reverses senescence-like phenotype in mutant BRAF melanoma. / 07.08.2018 / PubMed / Full text
Cancer modeling by Transgene Electroporation in Adult Zebrafish (TEAZ). / 27.09.2018 / PubMed / Full text
Menopause and adipose tissue: miR-19a-3p is sensitive to hormonal replacement. / 05.01.2018 / PubMed / Full text

CCS

Frailty Significantly Associated with a Risk for Mid-term Outcomes in Elderly Chronic Coronary Syndrome Patients: a Prospective Study. / 01.12.2020 / PubMed / Full text
Microbleeds and Medial Temporal Atrophy Determine Cognitive Trajectories in Normal Aging: A Longitudinal PET-MRI Study. / 2020 / PubMed / Full text
Hippocampal Volume Loss, Brain Amyloid Accumulation, and APOE Status in Cognitively Intact Elderly Subjects. / 2019 / PubMed / Full text
Amyloid Load, Hippocampal Volume Loss, and Diffusion Tensor Imaging Changes in Early Phases of Brain Aging. / 2019 / PubMed / Full text
Lower bone mass is associated with subclinical atherosclerosis, endothelial dysfunction and carotid thickness in the very elderly. / 01.2020 / PubMed / Full text
Cardiovascular Risk Assessment and Follow-Up of Women After Hypertensive Disorders of Pregnancy:A Prospective Cohort Study. / 08.2019 / PubMed / Full text
T cell epigenetic remodeling and accelerated epigenetic aging are linked to long-term immune alterations in childhood cancer survivors. / 06.11.2018 / PubMed / Full text
Circulating microRNAs disclose biology of normal cognitive function in healthy elderly people - a discovery twin study. / 09.2018 / PubMed / Full text
High risk of hypogonadism in young male cancer survivors. / 03.2018 / PubMed / Full text

CDK2

p57 is a master regulator of human adipose derived stem cell quiescence and senescence. / 04.2020 / PubMed / Full text
Induction of Senescence in Cancer Cells by a Novel Combination of Cucurbitacin B and Withanone: Molecular Mechanism and Therapeutic Potential. / 22.05.2020 / PubMed / Full text
Cyclin-Dependent Kinase 2 in Cellular Senescence and Cancer. A Structural and Functional Review. / 2019 / PubMed / Full text
Tenovin-1 Induces Senescence and Decreases Wound-Healing Activity in Cultured Rat Primary Astrocytes. / 01.05.2019 / PubMed / Full text
Relationship between intermuscular adipose tissue infiltration and myostatin before and after aerobic exercise training. / 01.09.2018 / PubMed / Full text
Carvacrol nanoemulsion evokes cell cycle arrest, apoptosis induction and autophagy inhibition in doxorubicin resistant-A549 cell line. / 2018 / PubMed / Full text
Gut flora-dependent metabolite Trimethylamine-N-oxide accelerates endothelial cell senescence and vascular aging through oxidative stress. / 20.02.2018 / PubMed / Full text
Inhibition of CIP2A attenuates tumor progression by inducing cell cycle arrest and promoting cellular senescence in hepatocellular carcinoma. / 08.01.2018 / PubMed / Full text
G protein-coupled receptor kinase 4-induced cellular senescence and its senescence-associated gene expression profiling. / 15.11.2017 / PubMed / Full text

CDK6

Saturated Fatty Acids Promote Hepatocytic Senecence through Regulation of miR-34a/Cyclin-Dependent Kinase 6. / 24.09.2020 / PubMed / Full text
Hepatoprotective effects of hydroxysafflor yellow A in D-galactose-treated aging mice. / 15.08.2020 / PubMed / Full text
Anti-cell growth and anti-cancer stem cell activity of the CDK4/6 inhibitor palbociclib in breast cancer cells. / 05.2020 / PubMed / Full text
Compromising the constitutive p16 expression sensitizes human neuroblastoma cells to Hsp90 inhibition and promotes premature senescence. / 04.2020 / PubMed / Full text
Palbociclib Effectively Halts Proliferation but Fails to Induce Senescence in Patient-Derived Glioma Stem Cells. / 11.2019 / PubMed / Full text
Avenanthramide A Induces Cellular Senescence via miR-129-3p/Pirh2/p53 Signaling Pathway To Suppress Colon Cancer Growth. / 01.05.2019 / PubMed / Full text
Carvacrol nanoemulsion evokes cell cycle arrest, apoptosis induction and autophagy inhibition in doxorubicin resistant-A549 cell line. / 2018 / PubMed / Full text
Preclinical characterization of abemaciclib in hormone receptor positive breast cancer. / 19.09.2017 / PubMed / Full text
G protein-coupled receptor kinase 4-induced cellular senescence and its senescence-associated gene expression profiling. / 15.11.2017 / PubMed / Full text

CX3CR1

Monocytes present age-related changes in phospholipid concentration and decreased energy metabolism. / 04.2020 / PubMed / Full text
Muscle Injury Induces Postoperative Cognitive Dysfunction. / 17.02.2020 / PubMed / Full text
Dexamethasone Induces a Specific Form of Ramified Dysfunctional Microglia. / 02.2019 / PubMed / Full text
Surgical Trauma Exacerbates Cognitive Deficits and Neuroinflammation in Aged Rats: The Role of CX3CL1-CX3CR1 Signaling. / 01.08.2018 / PubMed / Full text
Repopulating retinal microglia restore endogenous organization and function under CX3CL1-CX3CR1 regulation. / 03.2018 / PubMed / Full text
Cryopreserved whole blood for the quantification of monocyte, T-cell and NK-cell subsets, and monocyte receptor expression by multi-color flow cytometry: A methodological study based on participants from the canadian longitudinal study on aging. / 05.2018 / PubMed / Full text
Microglia and Aging: The Role of the TREM2-DAP12 and CX3CL1-CX3CR1 Axes. / 22.01.2018 / PubMed / Full text
Strain specificities in age-related changes in mechanisms promoting and controlling rat spinal cord damage in experimental autoimmune encephalomyelitis. / 01.2018 / PubMed / Full text
Sex as a determinant of age-related changes in rat spinal cord inflammation-oxidation state. / 10.2017 / PubMed / Full text

DCX

GSK-3β activation accelerates early-stage consumption of Hippocampal Neurogenesis in senescent mice. / 2020 / PubMed / Full text
Doublecortin and IGF-1R protein levels are reduced in spite of unchanged DNA methylation in the hippocampus of aged rats. / 04.2020 / PubMed / Full text
Human Hippocampal Neurogenesis Persists in Aged Adults and Alzheimer's Disease Patients. / 06.06.2019 / PubMed / Full text
Age-related changes in Ki-67 and DCX expression in the BALB/ c mouse (Mus Musculus) brain. / 02.2019 / PubMed / Full text
Inflammation-induced Gro1 triggers senescence in neuronal progenitors: effects of estradiol. / 11.09.2018 / PubMed / Full text
Neuroprotective Effects of the Multitarget Agent AVCRI104P3 in Brain of Middle-Aged Mice. / 04.09.2018 / PubMed / Full text
Differential effects of adolescent and adult-initiated voluntary exercise on context and cued fear conditioning. / 02.2019 / PubMed / Full text
Hippocampal neurogenesis in the C57BL/6J mice at early adulthood following prenatal alcohol exposure. / 04.2018 / PubMed / Full text
Puerarin and Amlodipine Improvement of D-Galactose-Induced Impairments of Behaviour and Neurogenesis in Mouse Dentate Gyrus: Correlation with Glucocorticoid Receptor Expression. / 11.2017 / PubMed / Full text

E2F1

Regulation of E2F1 activity via PKA-mediated phosphorylations. / 2020 / PubMed / Full text
Astragaloside IV ameliorates radiation-induced senescence via antioxidative mechanism. / 08.2020 / PubMed / Full text
E2F1 mediates the downregulation of POLD1 in replicative senescence. / 07.2019 / PubMed / Full text
Low dose Emodin induces tumor senescence for boosting breast cancer chemotherapy via silencing NRARP. / 10.11.2018 / PubMed / Full text
Downregulation of FOXP1 correlates with tendon stem/progenitor cells aging. / 26.09.2018 / PubMed / Full text
Loss of circadian protein TIMELESS accelerates the progression of cellular senescence. / 18.09.2018 / PubMed / Full text
Transcriptional Repression of High-Mobility Group Box 2 by p21 in Radiation-Induced Senescence. / 30.04.2018 / PubMed / Full text
Genome-wide association study and annotating candidate gene networks affecting age at first calving in Nellore cattle. / 12.2017 / PubMed / Full text
Triptolide Promotes Senescence of Prostate Cancer Cells Through Histone Methylation and Heterochromatin Formation / 27.09.2017 / PubMed / Full text

ELOVL2

ELOVL2: Not just a biomarker of aging. / 2020 / PubMed / Full text
The lipid elongation enzyme ELOVL2 is a molecular regulator of aging in the retina. / 02.2020 / PubMed / Full text
Human aging DNA methylation signatures are conserved but accelerated in cultured fibroblasts. / 10.2019 / PubMed / Full text
Cell and tissue type independent age-associated DNA methylation changes are not rare but common. / 27.11.2018 / PubMed / Full text
DNA methylation of the ELOVL2, FHL2, KLF14, C1orf132/MIR29B2C, and TRIM59 genes for age prediction from blood, saliva, and buccal swab samples. / 01.2019 / PubMed / Full text
Proof of concept study of age-dependent DNA methylation markers across different tissues by massive parallel sequencing. / 09.2018 / PubMed / Full text
Age-related DNA methylation changes are tissue-specific with ELOVL2 promoter methylation as exception. / 30.05.2018 / PubMed / Full text
DNA methylation levels in candidate genes associated with chronological age in mammals are not conserved in a long-lived seabird. / 2017 / PubMed / Full text
Chronological age prediction based on DNA methylation: Massive parallel sequencing and random forest regression. / 11.2017 / PubMed / Full text

ERCC1

Chronic Sildenafil Treatment Improves Vasomotor Function in a Mouse Model of Accelerated Aging. / 30.06.2020 / PubMed / Full text
Local endothelial DNA repair deficiency causes aging-resembling endothelial-specific dysfunction. / 17.04.2020 / PubMed / Full text
Tissue specificity of senescent cell accumulation during physiologic and accelerated aging of mice. / 03.2020 / PubMed / Full text
Deficiency in the DNA repair protein ERCC1 triggers a link between senescence and apoptosis in human fibroblasts and mouse skin. / 03.2020 / PubMed / Full text
Aerobic exercise promotes the expression of ERCC1 to prolong lifespan: A new possible mechanism. / 01.2019 / PubMed / Full text
Dysregulation of DAF-16/FOXO3A-mediated stress responses accelerates oxidative DNA damage induced aging. / 09.2018 / PubMed / Full text
ERCC1-deficient cells and mice are hypersensitive to lipid peroxidation. / 20.08.2018 / PubMed / Full text
Spontaneous DNA damage to the nuclear genome promotes senescence, redox imbalance and aging. / 07.2018 / PubMed / Full text
Oxidation Products of 5-Methylcytosine are Decreased in Senescent Cells and Tissues of Progeroid Mice. / 09.07.2018 / PubMed / Full text

FES

An outpatient Tai Chi program: Effects on veterans' functional outcomes. / 26.11.2020 / PubMed / Full text
Gait Function in Adults Aged 50 Years and Older With Spina Bifida. / 07.11.2020 / PubMed / Full text
A Single Question as a Screening Tool to Assess Fear of Falling in Young-Old Community-Dwelling Persons. / 09.2020 / PubMed / Full text
Fall-related efficacy is a useful and independent index to detect fall risk in Japanese community-dwelling older people: a 1-year longitudinal study. / 29.10.2019 / PubMed / Full text
Investigating Changes in Real-time Conscious Postural Processing by Older Adults during Different Stance Positions Using Electroencephalography Coherence. / 10-12.2019 / PubMed / Full text
Effectiveness of Daily Use of Bilateral Custom-Made Ankle-Foot Orthoses on Balance, Fear of Falling, and Physical Activity in Older Adults: A Randomized Controlled Trial. / 2019 / PubMed / Full text
Decline in sensorimotor systems explains reduced falls self-efficacy. / 10.2018 / PubMed / Full text
Fear of Falling in Older Adults with Diabetes Mellitus: The IMIAS Study. / 09.2018 / PubMed / Full text
Cross-cultural adaptation and measurement properties testing of the Iconographical Falls Efficacy Scale (Icon-FES). / 07-08.2018 / PubMed / Full text

HSF1

A Mitochondrial Stress-Specific Form of HSF1 Protects against Age-Related Proteostasis Collapse. / 28.09.2020 / PubMed / Full text
Heat shock factor 1-mediated transcription activation of Omi/HtrA2 induces myocardial mitochondrial apoptosis in the aging heart. / 18.10.2019 / PubMed / Full text
Multifactorial Attenuation of the Murine Heat Shock Response With Age. / 25.09.2020 / PubMed / Full text
Nutrition and water temperature regulate the expression of heat-shock proteins in golden pompano larvae (Trachinotus ovata, Limmaeus 1758). / 04.2019 / PubMed / Full text
CCAR-1 is a negative regulator of the heat-shock response in Caenorhabditis elegans. / 10.2018 / PubMed / Full text
Modulation of Heat Shock Factor 1 Activity through Silencing of Ser303/Ser307 Phosphorylation Supports a Metabolic Program Leading to Age-Related Obesity and Insulin Resistance. / 15.09.2018 / PubMed / Full text
The longevity SNP rs2802292 uncovered: HSF1 activates stress-dependent expression of FOXO3 through an intronic enhancer. / 20.06.2018 / PubMed / Full text
Acute HSF1 depletion induces cellular senescence through the MDM2-p53-p21 pathway in human diploid fibroblasts. / 08.05.2018 / PubMed / Full text
Azadiradione Restores Protein Quality Control and Ameliorates the Disease Pathogenesis in a Mouse Model of Huntington's Disease. / 08.2018 / PubMed / Full text

JAK2

Senescence in Monocytes Facilitates Dengue Virus Infection by Increasing Infectivity. / 2020 / PubMed / Full text
Quercetin Directly Targets JAK2 and PKCδ and Prevents UV-Induced Photoaging in Human Skin. / 23.10.2019 / PubMed / Full text
[Red blood cell lifespan detected by endogenous carbon monoxide breath test in patients with polycythemia vera]. / 01.10.2019 / PubMed / Full text
Roles of JAK2 in Aging, Inflammation, Hematopoiesis and Malignant Transformation. / 08.08.2019 / PubMed / Full text
The mir-465 family is upregulated with age and attenuates growth hormone signaling in mouse liver. / 04.2019 / PubMed / Full text
Clonal hematopoiesis: Genes and underlying mechanisms in cardiovascular disease development. / 06.2019 / PubMed / Full text
Distinctive features of polycythaemia vera in New Zealand Polynesians. / 21.09.2018 / PubMed
Immunologic effects of chronic administration of tofacitinib, a Janus kinase inhibitor, in cynomolgus monkeys and rats - Comparison of juvenile and adult responses. / 04.2018 / PubMed / Full text
Molecular Pathogenesis of Myeloproliferative Neoplasms: Influence of Age and Gender. / 10.2017 / PubMed / Full text

LPO

[Features of the changes in lipid peroxidation and activity of Na+/K+-ATPase in the brain of the aged rats in the conditions of two-vessel cerebral ischemia/reperfusion.] / 2019 / PubMed
Exercise training initiated at old stage of lifespan attenuates aging-and ovariectomy-induced cardiac and renal oxidative stress: Role of baroreflex. / 09.2019 / PubMed / Full text
Tris(1,3-dichloro-2-propyl) phosphate accelerated the aging process induced by the 4-hydroxynon-2-enal response to reactive oxidative species in Caenorhabditis elegans. / 03.2019 / PubMed / Full text
Physical Exercise Attenuates Oxidative Stress and Morphofunctional Cerebellar Damages Induced by the Ethanol Binge Drinking Paradigm from Adolescence to Adulthood in Rats. / 2019 / PubMed / Full text
[Effect of cryopreserved cord blood nucleated cells on course of pathological processes in progressive aging of brain (experimental study).] / 2018 / PubMed
Analysis of Plasma MicroRNAs as Predictors and Biomarkers of Aging and Frailty in Humans. / 2018 / PubMed / Full text
ERCC1-deficient cells and mice are hypersensitive to lipid peroxidation. / 20.08.2018 / PubMed / Full text
Antioxidant action of grape seed polyphenols and aerobic exercise in improving neuronal number in the hippocampus is associated with decrease in lipid peroxidation and hydrogen peroxide in adult and middle-aged rats. / 01.2018 / PubMed / Full text
The antioxidative and anti-aging effects of acidic- and alkalic-extractable mycelium polysaccharides by Agrocybe aegerita (Brig.) Sing. / 01.2018 / PubMed / Full text

MFN2

Thioredoxin protects mitochondrial structure, function and biogenesis in myocardial ischemia-reperfusion via redox-dependent activation of AKT-CREB- PGC1α pathway in aged mice. / 13.10.2020 / PubMed / Full text
MFN2 contributes to metabolic disorders and inflammation in the aging of rat chondrocytes and osteoarthritis. / 08.2020 / PubMed / Full text
Mitofusin 2 plays a role in oocyte and follicle development, and is required to maintain ovarian follicular reserve during reproductive aging. / 16.06.2019 / PubMed / Full text
Mitochondrial Quality Control in Aging and Heart Failure: Influence of Ketone Bodies and Mitofusin-Stabilizing Peptides. / 2019 / PubMed / Full text
Low MFN2 expression related to ageing in granulosa cells is associated with assisted reproductive technology outcome. / 02.2019 / PubMed / Full text
Loss of sirtuin 1 and mitofusin 2 contributes to enhanced ischemia/reperfusion injury in aged livers. / 08.2018 / PubMed / Full text
Increased Degradation Rates in the Components of the Mitochondrial Oxidative Phosphorylation Chain in the Cerebellum of Old Mice. / 2018 / PubMed / Full text
Slower Dynamics and Aged Mitochondria in Sporadic Alzheimer's Disease. / 2017 / PubMed / Full text
Dietary supplementation with acetyl-l-carnitine counteracts age-related alterations of mitochondrial biogenesis, dynamics and antioxidant defenses in brain of old rats. / 11.2017 / PubMed / Full text

TSPO

Age and Sex Influence the Neuro-inflammatory Response to a Peripheral Acute LPS Challenge. / 2019 / PubMed / Full text
Upregulation of cannabinoid receptor type 2, but not TSPO, in senescence-accelerated neuroinflammation in mice: a positron emission tomography study. / 10.11.2019 / PubMed / Full text
Effects of age, BMI and sex on the glial cell marker [[TSPO]] - a multicentre [ C]PBR28 HRRT PET study. / 10.2019 / PubMed / Full text
Concentration, distribution, and influence of aging on the 18 kDa translocator protein in human brain: Implications for brain imaging studies. / 05.2020 / PubMed / Full text
Microglial response to increasing amyloid load saturates with aging: a longitudinal dual tracer in vivo μPET-study. / 06.11.2018 / PubMed / Full text
Age Influences Microglial Activation After Cuprizone-Induced Demyelination. / 2018 / PubMed / Full text
[[TSPO]] ligand PK11195 improves Alzheimer-related outcomes in aged female 3xTg-AD mice. / 14.09.2018 / PubMed / Full text
Imaging studies of the HIV-infected brain. / 2018 / PubMed / Full text
Steroidogenic abnormalities in translocator protein knockout mice and significance in the aging male. / 02.01.2018 / PubMed / Full text

XBP1

Age-dependent impairment of adipose-derived stem cells isolated from horses. / 03.01.2020 / PubMed / Full text
Effects of a resistance-training programme on endoplasmic reticulum unfolded protein response and mitochondrial functions in PBMCs from elderly subjects. / 08.2019 / PubMed / Full text
[Protective effect of Wuzi Yanzong recipe on testicular germ cell apoptosis in natural ageing rats through endoplasmic reticulum stress]. / 10.2018 / PubMed / Full text
Protective effect of Wuzi Yanzong recipe on testicular dysfunction through inhibition of germ cell apoptosis in ageing rats via endoplasmic reticulum stress. / 03.2019 / PubMed / Full text
Loss of XBP1 accelerates age-related decline in retinal function and neurodegeneration. / 04.04.2018 / PubMed / Full text
A decay of the adaptive capacity of the unfolded protein response exacerbates Alzheimer's disease. / 03.2018 / PubMed / Full text
Amyloid-β42 clearance and neuroprotection mediated by X-box binding protein 1 signaling decline with aging in the Drosophila brain. / 12.2017 / PubMed / Full text
Ageing sensitized by iPLA β deficiency induces liver fibrosis and intestinal atrophy involving suppression of homeostatic genes and alteration of intestinal lipids and bile acids. / 12.2017 / PubMed / Full text
ER stress and distinct outputs of the IRE1α RNase control proliferation and senescence in response to oncogenic Ras. / 12.09.2017 / PubMed / Full text

BCL2

Soy isoflavones protect against oxidative stress and diminish apoptosis in ovary of middle-aged female rats. / 07.2019 / PubMed / Full text
Nrdp1 is involved in hippocampus apoptosis in cardiopulmonary bypass-induced cognitive dysfunction via the regulation of ErbB3 protein levels. / 04.2019 / PubMed / Full text
Self-Digestion for Lifespan Extension: Enhanced Autophagy Delays Aging. / 16.08.2018 / PubMed / Full text
Disruption of the beclin 1-BCL2 autophagy regulatory complex promotes longevity in mice. / 06.2018 / PubMed / Full text
Sestrins are differentially expressed with age in the skeletal muscle of men: A cross-sectional analysis. / 09.2018 / PubMed / Full text
Autophagy regulates the degeneration of the auditory cortex through the AMPK-mTOR-ULK1 signaling pathway. / 04.2018 / PubMed / Full text
The effect of ARC ablation on skeletal muscle morphology, function, and apoptotic signaling during aging. / 01.2018 / PubMed / Full text
High-Throughput Functional Genetic and Compound Screens Identify Targets for Senescence Induction in Cancer. / 17.10.2017 / PubMed / Full text

CDKN2A

Association between Nrf2 and CDKN2A expression in patients with end-stage renal disease: a pilot study. / 13.07.2020 / PubMed / Full text
Analysis of somatic mutations identifies signs of selection during in vitro aging of primary dermal fibroblasts. / 12.2019 / PubMed / Full text
Analysis of the putative tumor suppressor gene cdkn2ab in pigment cells and melanoma of Xiphophorus and medaka. / 03.2019 / PubMed / Full text
In vitro behavior and UV response of melanocytes derived from carriers of [[CDKN2A]] mutations and MC1R variants. / 03.2019 / PubMed / Full text
Endothelial PPARγ (Peroxisome Proliferator-Activated Receptor-γ) Is Essential for Preventing Endothelial Dysfunction With Aging. / 07.2018 / PubMed / Full text
Upregulation of lactate-inducible snail protein suppresses oncogene-mediated senescence through p16 inactivation. / 26.02.2018 / PubMed / Full text
Cellular aging dynamics after acute malaria infection: A 12-month longitudinal study. / 02.2018 / PubMed / Full text
ARID1A suppresses malignant transformation of human pancreatic cells via mediating senescence-associated miR-503/[[CDKN2A]] regulatory axis. / 18.11.2017 / PubMed / Full text

CFTR

Exercise Physiology Across the Lifespan in Cystic Fibrosis. / 2019 / PubMed / Full text
Reduced expression of the Ion channel CFTR contributes to airspace enlargement as a consequence of aging and in response to cigarette smoke in mice. / 02.09.2019 / PubMed / Full text
Is cellular senescence involved in cystic fibrosis? / 14.02.2019 / PubMed / Full text
Autophagy delays progression of the two most frequent human monogenetic lethal diseases: cystic fibrosis and Wilson disease. / 19.12.2018 / PubMed / Full text
The Clinical Biology of Cystic Fibrosis Transmembrane Regulator Protein: Its Role and Function in Extrapulmonary Disease. / 03.2019 / PubMed / Full text
[Ageing with cystic fibrosis: Classical and emerging comorbidities in adults with cystic fibrosis]. / 10.2018 / PubMed / Full text
A review of inflammatory mechanism in airway diseases. / 01.2019 / PubMed / Full text
Up-to-date and projected estimates of survival for people with cystic fibrosis using baseline characteristics: A longitudinal study using UK patient registry data. / 03.2018 / PubMed / Full text

COMT

The geriatric pain experience in mice: intact cutaneous thresholds but altered responses to tonic and chronic pain. / 05.2020 / PubMed / Full text
A candidate gene study of risk for dementia in older, postmenopausal women: Results from the Women's Health Initiative Memory Study. / 05.2019 / PubMed / Full text
Frontoparietal cortical thickness mediates the effect of COMT Val Met polymorphism on age-associated executive function. / 01.2019 / PubMed / Full text
[MELATONIN: THE POSSIBILITY TO ANALYSE THE MARKER OF AGE-RELATED PATHOLOGY IN THE BUCCAL EPITHELIUM AND URINE]. / 2017 / PubMed
The Moderating Role of COMT and BDNF Polymorphisms on Transfer Effects Following Multi- and Single-Domain Cognitive Training Among Community-Dwelling Shanghainese Older Adults. / 2018 / PubMed / Full text
Genetic Risk for Age-Related Cognitive Impairment Does Not Predict Cognitive Performance in Middle Age. / 2018 / PubMed / Full text
Dopamine-Related Genotypes and Physical Activity Change During an Intervention: The Lifestyle Interventions and Independence for Elders Study. / 07.2018 / PubMed / Full text
Genetic Biomarkers on Age-Related Cognitive Decline. / 2017 / PubMed / Full text

CTRL

Aging reduces the maximal level of peripheral fatigue tolerable and impairs exercise capacity. / 01.12.2020 / PubMed / Full text
miR-146a Plasma Levels Are Not Altered in Alzheimer's Disease but Correlate With Age and Illness Severity. / 2019 / PubMed / Full text
Centrally-mediated regulation of peripheral fatigue during knee extensor exercise and consequences on the force-duration relationship in older men. / 06.2020 / PubMed / Full text
Non-linear registration improves statistical power to detect hippocampal atrophy in aging and dementia. / 2019 / PubMed / Full text
Plyometric exercise improves jumping performance and skeletal muscle contractile properties in seniors. / 01.03.2019 / PubMed / Full text
Soy isoflavones protect against oxidative stress and diminish apoptosis in ovary of middle-aged female rats. / 07.2019 / PubMed / Full text
Heterogeneity of Thyroid Function and Impact of Peripheral Thyroxine Deiodination in Centenarians and Semi-Supercentenarians: Association With Functional Status and Mortality. / 16.05.2019 / PubMed / Full text
Evaluation of Lymphocyte Response to the Induced Oxidative Stress in a Cohort of Ageing Subjects, including Semisupercentenarians and Their Offspring. / 2018 / PubMed / Full text

CXCL12

Co-option of Neutrophil Fates by Tissue Environments. / 25.11.2020 / PubMed / Full text
Heme oxygenase-1 deficiency triggers exhaustion of hematopoietic stem cells. / 05.02.2020 / PubMed / Full text
Global Transcriptomic Profiling of the Bone Marrow Stromal Microenvironment during Postnatal Development, Aging, and Inflammation. / 03.12.2019 / PubMed / Full text
Long-term repopulation of aged bone marrow stem cells using young Sca-1 cells promotes aged heart rejuvenation. / 12.2019 / PubMed / Full text
Reducing CXCR4 Resulted in Impairing Proliferation and Promoting Aging. / 2018 / PubMed / Full text
Quantitative spatial analysis of haematopoiesis-regulating stromal cells in the bone marrow microenvironment by 3D microscopy. / 28.06.2018 / PubMed / Full text
Tumor microenvironment in functional adrenocortical adenomas: immune cell infiltration in cortisol-producing adrenocortical adenoma. / 07.2018 / PubMed / Full text
Systemic analysis of gene expression profiles in porcine granulosa cells during aging. / 14.11.2017 / PubMed / Full text

ERF

Angiotensin-Converting Enzyme Gene D/I Polymorphism in Relation to Endothelial Function and Endothelial-Released Factors in Chinese Women. / 2020 / PubMed / Full text
Projections of Ambient Temperature- and Air Pollution-Related Mortality Burden Under Combined Climate Change and Population Aging Scenarios: a Review. / 09.2020 / PubMed / Full text
Exome Sequencing Analysis Identifies Rare Variants in [i]ATM[/i] and [i]RPL8[/i] That Are Associated With Shorter Telomere Length. / 2020 / PubMed / Full text
The ERF transcription factor EPI1 is a negative regulator of dark-induced and jasmonate-stimulated senescence in [i]Arabidopsis[/i]. / 2016 / PubMed / Full text
Transcriptional regulation of Lonicera japonica Thunb. during flower development as revealed by comprehensive analysis of transcription factors. / 14.05.2019 / PubMed / Full text
Impact of Alternatively Polyadenylated Isoforms of ETHYLENE RESPONSE FACTOR4 with Activator and Repressor Function on Senescence in [i]Arabidopsis thaliana[/i] L. / 28.01.2019 / PubMed / Full text
Transcriptome analysis of leaf senescence in red clover ([i]Trifolium pratense[/i] L.). / 09.2018 / PubMed / Full text
Molecular and functional characterization of ShNAC1, an NAC transcription factor from Solanum habrochaites. / 06.2018 / PubMed / Full text

G6PD

G6PD overexpression protects from oxidative stress and age-related hearing loss. / 22.11.2020 / PubMed / Full text
The Sickle Effect: The Silent Titan Affecting Glycated Hemoglobin Reliability. / 12.08.2020 / PubMed / Full text
DNA damage and synaptic and behavioural disorders in glucose-6-phosphate dehydrogenase-deficient mice. / 01.2020 / PubMed / Full text
JNK modifies neuronal metabolism to promote proteostasis and longevity. / 06.2019 / PubMed / Full text
Antioxidant SMe1EC2 modulates pentose phosphate pathway and glutathione-dependent enzyme activities in tissues of aged diabetic rats. / 12.2017 / PubMed / Full text
Detection of a novel, primate-specific 'kill switch' tumor suppression mechanism that may fundamentally control cancer risk in humans: an unexpected twist in the basic biology of TP53. / 11.2018 / PubMed / Full text
Safety of Single-Dose Primaquine in G6PD-Deficient and G6PD-Normal Males in Mali Without Malaria: An Open-Label, Phase 1, Dose-Adjustment Trial. / 28.03.2018 / PubMed / Full text
Effect of age, period and birth-cohort on the frequency of glucose-6-phosphate dehydrogenase deficiency in Sardinian adults. / 02.2018 / PubMed / Full text

HDAC3

Histone deacetylase-3: Friend and foe of the brain. / 07.2020 / PubMed / Full text
Loss of HDAC3 contributes to meiotic defects in aged oocytes. / 12.2019 / PubMed / Full text
HDAC3-Mediated Repression of the [i]Nr4a[/i] Family Contributes to Age-Related Impairments in Long-Term Memory. / 19.06.2019 / PubMed / Full text
Budesonide, Aclidinium and Formoterol in combination limit inflammaging processes in bronchial epithelial cells exposed to cigarette smoke. / 04.2019 / PubMed / Full text
HDAC3 Regulates the Transition to the Homeostatic Myelinating Schwann Cell State. / 04.12.2018 / PubMed / Full text
Novel anti-aging gene NM_026333 contributes to proton-induced aging via NCX1-pathway. / 12.2018 / PubMed / Full text
Epigenetic regulation of the circadian gene Per1 contributes to age-related changes in hippocampal memory. / 20.08.2018 / PubMed / Full text
Histone deacetylase 1 expression is inversely correlated with age in the short-lived fish Nothobranchius furzeri. / 09.2018 / PubMed / Full text

IL10

The beneficial effect of physical exercise on inflammatory makers in older individuals. / 06.06.2020 / PubMed / Full text
Astrocyte senescence may drive alterations in GFAPα, CDKN2A p14 , and TAU3 transcript expression and contribute to cognitive decline. / 10.2019 / PubMed / Full text
Dietary Spray-Dried Porcine Plasma Prevents Cognitive Decline in Senescent Mice and Reduces Neuroinflammation and Oxidative Stress. / 01.02.2020 / PubMed / Full text
Age-dependent hepatic alterations induced by a high-fat high-fructose diet. / 05.2019 / PubMed / Full text
[i]Lactobacillus paracasei[/i] PS23 decelerated age-related muscle loss by ensuring mitochondrial function in SAMP8 mice. / 29.01.2019 / PubMed / Full text
Inflammatory cytokines and immune system modulation by aerobic versus resisted exercise training for elderly. / 03.2018 / PubMed / Full text
Pentoxifylline, dexamethasone and azithromycin demonstrate distinct age-dependent and synergistic inhibition of TLR- and inflammasome-mediated cytokine production in human newborn and adult blood in vitro. / 2018 / PubMed / Full text
Deficiency in Protein Tyrosine Phosphatase PTP1B Shortens Lifespan and Leads to Development of Acute Leukemia. / 01.01.2018 / PubMed / Full text

INS

Melatonin protects INS-1 pancreatic β-cells from apoptosis and senescence induced by glucotoxicity and glucolipotoxicity. / 03.07.2020 / PubMed / Full text
Nicotine triggers islet β cell senescence to facilitate the progression of type 2 diabetes. / 08.2020 / PubMed / Full text
Reducing INS-IGF1 signaling protects against non-cell autonomous vesicle rupture caused by SNCA spreading. / 05.2020 / PubMed / Full text
Insulin-like peptides and the mTOR-TFEB pathway protect [i]Caenorhabditis elegans[/i] hermaphrodites from mating-induced death. / 08.07.2019 / PubMed / Full text
The Maghreb demographic transition: Tunisia case study. / 10-11.2018 / PubMed
Temporal pattern of neuronal insulin release during Caenorhabditis elegans aging: Role of redox homeostasis. / 02.2019 / PubMed / Full text
A functional study of all 40 [i]Caenorhabditis elegans[/i] insulin-like peptides. / 26.10.2018 / PubMed / Full text
The anti-aging protein Klotho is induced by GABA therapy and exerts protective and stimulatory effects on pancreatic beta cells. / 02.12.2017 / PubMed / Full text

KRAS

Chemical Pathology of Homocysteine VIII. Effects of Tocotrienol, Geranylgeraniol, and Squalene on Thioretinaco Ozonide, Mitochondrial Permeability, and Oxidative Phosphorylation in Arteriosclerosis, Cancer, Neurodegeneration and Aging. / 09.2020 / PubMed
Senescence-Induced Vascular Remodeling Creates Therapeutic Vulnerabilities in Pancreas Cancer. / 16.04.2020 / PubMed / Full text
Oncogenic mutations in histologically normal endometrium: the new normal? / 10.2019 / PubMed / Full text
Inhibition of ERK1/2 in cancer-associated pancreatic stellate cells suppresses cancer-stromal interaction and metastasis. / 27.05.2019 / PubMed / Full text
Comprehensive transcriptome profiling in elderly cancer patients reveals aging-altered immune cells and immune checkpoints. / 01.04.2019 / PubMed / Full text
O-GlcNAcylation is required for mutant KRAS-induced lung tumorigenesis. / 01.11.2018 / PubMed / Full text
E47 Governs the MYC-CDKN1B/p27 -RB Network to Growth Arrest PDA Cells Independent of CDKN2A/p16 and Wild-Type p53. / 2018 / PubMed / Full text
ARID1A suppresses malignant transformation of human pancreatic cells via mediating senescence-associated miR-503/[[CDKN2A]] regulatory axis. / 18.11.2017 / PubMed / Full text

MMP2

Cellular retinoic acid binding protein-II expression and its potential role in skin aging. / 18.03.2019 / PubMed / Full text
[Effect of saponins extracted from Panax japonicas on inhibiting myocardial fibrosis by TGF-β1/Smad3 signaling pathway in aging rats]. / 11.2018 / PubMed / Full text
TMT-Based Quantitative Proteomic Analysis Reveals Proteomic Changes Involved in Longevity. / 07.2019 / PubMed / Full text
MicroRNA-338-5p plays a tumor suppressor role in glioma through inhibition of the MAPK-signaling pathway by binding to FOXD1. / 12.2018 / PubMed / Full text
PM2.5 promotes abdominal aortic aneurysm formation in angiotensin Ⅱ-infused apoe-/- mice. / 08.2018 / PubMed / Full text
Activation of DNA demethylases attenuates aging-associated arterial stiffening and hypertension. / 08.2018 / PubMed / Full text
MMP2-A2M interaction increases ECM accumulation in aged rat kidney and its modulation by calorie restriction. / 19.01.2018 / PubMed / Full text
Systemic analysis of gene expression profiles in porcine granulosa cells during aging. / 14.11.2017 / PubMed / Full text

MTOR

The roles of MTOR and miRNAs in endothelial cell senescence. / 10.2020 / PubMed / Full text
Autophagy drives fibroblast senescence through MTORC2 regulation. / 11.2020 / PubMed / Full text
The GID ubiquitin ligase complex is a regulator of AMPK activity and organismal lifespan. / 09.2020 / PubMed / Full text
The double-edged sword of MTOR in autophagy deficiency induced-liver injury and tumorigenesis. / 09.2019 / PubMed / Full text
A large-scale CRISPR screen and identification of essential genes in cellular senescence bypass. / 20.06.2019 / PubMed / Full text
Effect of young exosomes injected in aged mice. / 2018 / PubMed / Full text
Inhibition of glioma growth by flavokawain B is mediated through endoplasmic reticulum stress induced autophagy. / 2018 / PubMed / Full text
Endothelial replicative senescence delayed by the inhibition of MTORC1 signaling involves MicroRNA-107. / 08.2018 / PubMed / Full text

MYB

Transcriptome profiling of postharvest shoots identifies PheNAP2- and PheNAP3-promoted shoot senescence. / 01.12.2019 / PubMed / Full text
Systematic Analysis of MYB Family Genes in Potato and Their Multiple Roles in Development and Stress Responses. / 30.07.2019 / PubMed / Full text
Transcriptional regulation of Lonicera japonica Thunb. during flower development as revealed by comprehensive analysis of transcription factors. / 14.05.2019 / PubMed / Full text
Transgenic expression of rice MYB102 (OsMYB102) delays leaf senescence and decreases abiotic stress tolerance in Arabidopsis thaliana. / 11.2019 / PubMed / Full text
The WRKY transcription factor GhWRKY27 coordinates the senescence regulatory pathway in upland cotton (Gossypium hirsutum L.). / 29.03.2019 / PubMed / Full text
Rice transcription factor OsMYB102 delays leaf senescence by down-regulating abscisic acid accumulation and signaling. / 09.05.2019 / PubMed / Full text
Transcriptome analysis of leaf senescence in red clover ([i]Trifolium pratense[/i] L.). / 09.2018 / PubMed / Full text
The Direct Involvement of Dark-Induced Tic55 Protein in Chlorophyll Catabolism and Its Indirect Role in the MYB108-NAC Signaling Pathway during Leaf Senescence in [i]Arabidopsis thaliana[/i]. / 23.06.2018 / PubMed / Full text

NQO1

Augmentation of cellular NAD by NQO1 enzymatic action improves age-related hearing impairment. / 10.2019 / PubMed / Full text
Well-aging: A new strategy for skin homeostasis under multi-stressed conditions. / 02.2020 / PubMed / Full text
Limitations to adaptive homeostasis in an hyperoxia-induced model of accelerated ageing. / 06.2019 / PubMed / Full text
Link between cardiac function and the antioxidative defense mechanism in aged rats. / 11.06.2019 / PubMed / Full text
[Protective effect of Wuzi Yanzong recipe on testicular DNA oxidative damage in natural ageing rats]. / 07.2018 / PubMed / Full text
Benefits of Caloric Restriction in Longevity and Chemical-Induced Tumorigenesis Are Transmitted Independent of NQO1. / 16.01.2019 / PubMed / Full text
Overexpression of CYB5R3 and NQO1, two NAD -producing enzymes, mimics aspects of caloric restriction. / 08.2018 / PubMed / Full text
Sargassum fusiforme Polysaccharide Rejuvenat es the Small Intestine in Mice Through Altering its Physiol ogy and Gut Microbiota Composition. / 2017 / PubMed / Full text

PIP

Potentially inappropriate prescriptions according to explicit and implicit criteria in patients with multimorbidity and polypharmacy. MULTIPAP: A cross-sectional study. / 2020 / PubMed / Full text
Quality of prescribing predicts hospitalisation in octogenarians: life and living in advanced age: a cohort study in New Zealand (LiLACS NZ). / 19.12.2019 / PubMed / Full text
A Systematic Review of Studies of the STOPP/START 2015 and American Geriatric Society Beers 2015 Criteria in Patients ≥ 65 Years. / 2019 / PubMed / Full text
Intracellular cholesterol stimulates ENaC by interacting with phosphatidylinositol‑4,5‑bisphosphate and mediates cyclosporine A-induced hypertension. / 01.07.2019 / PubMed / Full text
Medicinal products for geriatric patients in Germany : Current status of regulatory requirements and clinical reality. / 07.2020 / PubMed / Full text
Patterns of multi-morbidity and prediction of hospitalisation and all-cause mortality in advanced age. / 01.03.2018 / PubMed / Full text
A Pharmacist-Led Program to Evaluate and Reduce Polypharmacy and Potentially Inappropriate Prescribing in Older HIV-Positive Patients. / 12.2017 / PubMed / Full text
Prevalence and predictors of potentially inappropriate prescribing of central nervous system and psychotropic drugs among elderly patients: A national population study in Korea. / 01.2018 / PubMed / Full text

PML

Progressive multifocal leukoencephalopathy in dimethyl fumarate-treated multiple sclerosis patients. / 18.08.2020 / PubMed / Full text
PML2-mediated thread-like nuclear bodies mark late senescence in Hutchinson-Gilford progeria syndrome. / 06.2020 / PubMed / Full text
Trophoblast type-specific expression of senescence markers in the human placenta. / 15.09.2019 / PubMed / Full text
PML nuclear bodies are recruited to persistent DNA damage lesions in an RNF168-53BP1 dependent manner and contribute to DNA repair. / 06.2019 / PubMed / Full text
Nuclear Nox4 interaction with prelamin A is associated with nuclear redox control of stem cell aging. / 24.10.2018 / PubMed / Full text
Aging and lymphocyte changes by immunomodulatory therapies impact PML risk in multiple sclerosis patients. / 07.2018 / PubMed / Full text
SOCS1 regulates senescence and ferroptosis by modulating the expression of p53 target genes. / 28.10.2017 / PubMed / Full text
Age as a risk factor for early onset of natalizumab-related progressive multifocal leukoencephalopathy. / 10.2017 / PubMed / Full text

S100A9

Cigarette smoke induction of S100A9 contributes to chronic obstructive pulmonary disease. / 23.09.2020 / PubMed / Full text
Modulation of KDM1A with vafidemstat rescues memory deficit and behavioral alterations. / 2020 / PubMed / Full text
Cellular senescence induced by S100A9 in mesenchymal stromal cells through NLRP3 inflammasome activation. / 14.11.2019 / PubMed / Full text
S100A9 extends lifespan in insulin deficiency. / 07.08.2019 / PubMed / Full text
S100A8, which increases with age, induces cellular senescence-like changes in bovine oviduct epithelial cells. / 09.2019 / PubMed / Full text
Fetal articular cartilage regeneration versus adult fibrocartilaginous repair: secretome proteomics unravels molecular mechanisms in an ovine model. / 06.07.2018 / PubMed / Full text
Intranasally Administered S100A9 Amyloids Induced Cellular Stress, Amyloid Seeding, and Behavioral Impairment in Aged Mice. / 20.06.2018 / PubMed / Full text
S100A9 Protein Aggregates Boost Hippocampal Glutamate Modifying Monoaminergic Neurochemistry: A Glutamate Antibody Sensitive Outcome on Alzheimer-like Memory Decline. / 21.03.2018 / PubMed / Full text

SFN

The phytoprotective agent sulforaphane prevents inflammatory degenerative diseases and age-related pathologies via Nrf2-mediated hormesis. / 04.11.2020 / PubMed / Full text
Multi-Omic Analysis Reveals Different Effects of Sulforaphane on the Microbiome and Metabolome in Old Compared to Young Mice. / 29.09.2020 / PubMed / Full text
Sulforaphane controls the release of paracrine factors by keratinocytes and thus mitigates particulate matter-induced premature skin aging by suppressing melanogenesis and maintaining collagen homeostasis. / 10.2020 / PubMed / Full text
Sulforaphane Inhibits Autophagy and Induces Exosome-Mediated Paracrine Senescence via Regulating mTOR/TFE3. / 07.2020 / PubMed / Full text
Effects of sulforaphane on D-galactose-induced liver aging in rats: Role of keap-1/nrf-2 pathway. / 15.07.2019 / PubMed / Full text
Sulforaphane - role in aging and neurodegeneration. / 10.2019 / PubMed / Full text
The secretory phenotype of senescent astrocytes isolated from Wistar newborn rats changes with anti-inflammatory drugs, but does not have a short-term effect on neuronal mitochondrial potential. / 10.2018 / PubMed / Full text
Sulforaphane reactivates cellular antioxidant defense by inducing Nrf2/ARE/Prdx6 activity during aging and oxidative stress. / 26.10.2017 / PubMed / Full text

SST

The distance to death perceptions of older adults explain why they age in place: A theoretical examination. / 09.2020 / PubMed / Full text
Population Segmentation Based on Healthcare Needs: Validation of a Brief Clinician-Administered Tool. / 30.06.2020 / PubMed / Full text
Examination on how emotion regulation mediates the relationship between future time perspective and well-being: a counter-evidence to the socioemotional selectivity theory. / 03.2020 / PubMed / Full text
Shear-Wave and Strain Ultrasound Elastography of the Supraspinatus and Infraspinatus Tendons in Patients with Idiopathic Adhesive Capsulitis of the Shoulder: A Prospective Case-Control Study. / 07.2019 / PubMed / Full text
Counting down while time flies: implications of age-related time acceleration for goal pursuit across adulthood. / 04.2019 / PubMed / Full text
Relative costs and benefits of alternative reproductive phenotypes at different temperatures - genotype-by-environment interactions in a sexually selected trait. / 11.07.2018 / PubMed / Full text
Climate change and functional traits affect population dynamics of a long-lived seabird. / 07.2018 / PubMed / Full text
Influence of season, age and management on scrotal thermal profile in Murrah bulls using scrotal infrared digital thermography. / 12.2017 / PubMed / Full text

STAT1

STAT1-p53-p21axis-dependent stress-induced progression of chronic nephrosis in adriamycin-induced mouse model. / 08.2020 / PubMed / Full text
Age-Dependent and -Independent Effects of Perivascular Adipose Tissue and Its Paracrine Activities during Neointima Formation. / 31.12.2019 / PubMed / Full text
Legumain-deficient macrophages promote senescence of tumor cells by sustaining JAK1/STAT1 activation. / 01.03.2020 / PubMed / Full text
Inflammaging: Age and Systemic, Cellular, and Nuclear Inflammatory Biology in Older Adults. / 04.10.2019 / PubMed / Full text
Age-specific changes in the molecular phenotype of patients with moderate-to-severe atopic dermatitis. / 07.2019 / PubMed / Full text
Identification of key genes and transcription factors in aging mesenchymal stem cells by DNA microarray data. / 15.04.2019 / PubMed / Full text
Transcriptome analysis reveals immune-related gene expression changes with age in giant panda ([i]Ailuropoda melanoleuca[/i]) blood. / 14.01.2019 / PubMed / Full text
A tyrosine kinase-activating variant Asn666Ser in PDGFRB causes a progeria-like condition in the severe end of Penttinen syndrome. / 04.2019 / PubMed / Full text

ULK1

[Molecular mechanisms of mycelium of Cordyceps sinensis ameliorating renal tubular epithelial cells aging induced by D-galactose via inhibiting autophagy-related AMPK/ULK1 signaling activation]. / 03.2019 / PubMed / Full text
The autophagy-related gene [i]Atg101[/i] in [i]Drosophila[/i] regulates both neuron and midgut homeostasis. / 05.04.2019 / PubMed / Full text
Hyperoside attenuates renal aging and injury induced by D-galactose via inhibiting AMPK-ULK1 signaling-mediated autophagy. / 24.12.2018 / PubMed / Full text
Sarcopenia targeting with autophagy mechanism by exercise. / 01.2019 / PubMed / Full text
Young plasma attenuates age-dependent liver ischemia reperfusion injury. / 02.2019 / PubMed / Full text
Depletion of gamma-glutamylcyclotransferase in cancer cells induces autophagy followed by cellular senescence. / 2018 / PubMed / Full text
Responders and non-responders to influenza vaccination: A DNA methylation approach on blood cells. / 05.2018 / PubMed / Full text
Autophagy regulates the degeneration of the auditory cortex through the AMPK-mTOR-ULK1 signaling pathway. / 04.2018 / PubMed / Full text

ATF6

Cellular proteostasis decline in human senescence. / 30.11.2020 / PubMed / Full text
Impact of endoplasmic reticulum stress on oocyte aging mechanisms. / 01.08.2020 / PubMed / Full text
ER stress activates immunosuppressive network: implications for aging and Alzheimer's disease. / 05.2020 / PubMed / Full text
Towards Age-Related Anti-Inflammatory Therapy: Klotho Suppresses Activation of ER and Golgi Stress Response in Senescent Monocytes. / 21.01.2020 / PubMed / Full text
Reaction to Endoplasmic Reticulum Stress [i]via[/i] ATF6 in Amyotrophic Lateral Sclerosis Deteriorates With Aging. / 2019 / PubMed / Full text
[Protective effect of Wuzi Yanzong recipe on testicular germ cell apoptosis in natural ageing rats through endoplasmic reticulum stress]. / 10.2018 / PubMed / Full text
PGC-1α in aging and lifelong exercise training-mediated regulation of UPR in mouse liver. / 11.2017 / PubMed / Full text

ATG5

Autophagy and heat-shock response impair stress granule assembly during cellular senescence. / 12.2020 / PubMed / Full text
Effects of MUL1 and PARKIN on the circadian clock, brain and behaviour in Drosophila Parkinson's disease models. / 28.05.2019 / PubMed / Full text
Lifelong Football Training: Effects on Autophagy and Healthy Longevity Promotion. / 2019 / PubMed / Full text
The ATG5-binding and coiled coil domains of ATG16L1 maintain autophagy and tissue homeostasis in mice independently of the WD domain required for LC3-associated phagocytosis. / 04.2019 / PubMed / Full text
Inhibition of glioma growth by flavokawain B is mediated through endoplasmic reticulum stress induced autophagy. / 2018 / PubMed / Full text
Carvacrol nanoemulsion evokes cell cycle arrest, apoptosis induction and autophagy inhibition in doxorubicin resistant-A549 cell line. / 2018 / PubMed / Full text
Compromised autophagy precedes meniscus degeneration and cartilage damage in mice. / 11.2017 / PubMed / Full text

BCR

The presence of CLL-associated stereotypic B cell receptors in the normal BCR repertoire from healthy individuals increases with age. / 2019 / PubMed / Full text
Crucial Role of Increased Arid3a at the Pre-B and Immature B Cell Stages for B1a Cell Generation. / 2019 / PubMed / Full text
Effect of Age on NK Cell Compartment in Chronic Myeloid Leukemia Patients Treated With Tyrosine Kinase Inhibitors. / 2018 / PubMed / Full text
B cell responses to apoptotic cells in MFG-E8-/- mice. / 2018 / PubMed / Full text
Early Generated B-1-Derived B Cells Have the Capacity To Progress To Become Mantle Cell Lymphoma-like Neoplasia in Aged Mice. / 15.07.2018 / PubMed / Full text
Mean residual life regression with functional principal component analysis on longitudinal data for dynamic prediction. / 12.2018 / PubMed / Full text
NLR Nod1 signaling promotes survival of BCR-engaged mature B cells through up-regulated Nod1 as a positive outcome. / 02.10.2017 / PubMed / Full text

CCL11

CCL-11 or Eotaxin-1: An Immune Marker for Ageing and Accelerated Ageing in Neuro-Psychiatric Disorders. / 02.09.2020 / PubMed / Full text
Young bone marrow transplantation preserves learning and memory in old mice. / 2019 / PubMed / Full text
[The role of «Youth and aging proteins» in essential hypertension pathogenesis.] / 2018 / PubMed
Association between plasma CCL11 (eotaxin-1) and cognitive status in older adults: Differences between rural and urban dwellers. / 11.2018 / PubMed / Full text
Inflammaging impairs peripheral nerve maintenance and regeneration. / 12.2018 / PubMed / Full text
Stem Cell-Induced Pulp Regeneration Can Be Enhanced by Administration of CCL11-Neutralizing Antibody in the Ectopic Tooth Transplantation Model in the Aged Mice. / 02.2019 / PubMed / Full text
Inflammatory chemokine eotaxin-1 is correlated with age in heroin dependent patients under methadone maintenance therapy. / 01.02.2018 / PubMed / Full text

CCL5

CCL5 secreted by senescent theca-interstitial cells inhibits preantral follicular development via granulosa cellular apoptosis. / 12.2019 / PubMed / Full text
Inflammatory markers and occurrence of falls: Bambuí Cohort Study of Aging. / 01.04.2019 / PubMed / Full text
TMT-Based Quantitative Proteomic Analysis Reveals Proteomic Changes Involved in Longevity. / 07.2019 / PubMed / Full text
Burn wounds in the young versus the aged patient display differential immunological responses. / 09.2018 / PubMed / Full text
Urine Cytokine and Chemokine Levels Predict Urinary Tract Infection Severity Independent of Uropathogen, Urine Bacterial Burden, Host Genetics, and Host Age. / 09.2018 / PubMed / Full text
Immune senescence and biomarkers profile of Bambuí aged population-based cohort. / 03.2018 / PubMed / Full text
Predictive value of multiple cytokines and chemokines for mortality in an admixed population: 15-year follow-up of the Bambui-Epigen (Brazil) cohort study of aging. / 11.2017 / PubMed / Full text

CD19

Sequential treatment with aT19 cells generates memory CAR-T cells and prolongs the lifespan of Raji-B-NDG mice. / 28.01.2020 / PubMed / Full text
Stress-Induced Premature Senescence Promotes Proliferation by Activating the [i]SENEX[/i] and p16 /Retinoblastoma (Rb) Pathway in Diffuse Large B-Cell Lymphoma / 18.11.2019 / PubMed / Full text
Effects of pepsin and pepstatin on reflux tonsil hypertrophy in vitro. / 2018 / PubMed / Full text
Innate and adaptive immune dysregulation in critically ill ICU patients. / 05.07.2018 / PubMed / Full text
Vitamin D levels correlate with lymphocyte subsets in elderly patients with age-related diseases. / 16.05.2018 / PubMed / Full text
Normal variation of bone marrow B-cell precursors according to age - reference ranges for studies in myelodysplastic syndromes in Brazil. / 09.2018 / PubMed / Full text
Altered marginal zone and innate-like B cells in aged senescence-accelerated SAMP8 mice with defective IgG1 responses. / 17.08.2017 / PubMed / Full text

CD63

Cellular senescence contributes to age-dependent changes in circulating extracellular vesicle cargo and function. / 03.2020 / PubMed / Full text
Exosomal Notch3 from high glucose-stimulated endothelial cells regulates vascular smooth muscle cells calcification/aging. / 01.09.2019 / PubMed / Full text
Adiponectin promotes muscle regeneration through binding to T-cadherin. / 09.01.2019 / PubMed / Full text
Exosomes from hyperglycemia-stimulated vascular endothelial cells contain versican that regulate calcification/senescence in vascular smooth muscle cells. / 2019 / PubMed / Full text
The Aging Process Alters IL-1β and CD63 Levels Differently in Extracellular Vesicles Obtained from the Plasma and Cerebrospinal Fluid. / 2018 / PubMed / Full text
miRNA in Circulating Microvesicles as Biomarkers for Age-Related Cognitive Decline. / 2017 / PubMed / Full text
Circulating extracellular vesicles in the aging process: impact of aerobic exercise. / 03.2018 / PubMed / Full text

CDKN1A

Involvement of CDKN1A (p21) in cellular senescence in response to heat and irradiation stress during preimplantation development. / 05.2020 / PubMed / Full text
Chromatin remodeling factor BAZ1A regulates cellular senescence in both cancer and normal cells. / 15.07.2019 / PubMed / Full text
Histone demethylase KDM6B regulates 1,25-dihydroxyvitamin D3-induced senescence in glioma cells. / 08.2019 / PubMed / Full text
A Novel [i]Dnmt3a1[/i] Transcript Inhibits Adipogenesis. / 2018 / PubMed / Full text
Altered modulation of lamin A/C-HDAC2 interaction and p21 expression during oxidative stress response in HGPS. / 10.2018 / PubMed / Full text
Conditioned medium from stimulated macrophages inhibits growth but induces an inflammatory phenotype in breast cancer cells. / 10.2018 / PubMed / Full text
DNA damage and neurodegenerative phenotypes in aged Ciz1 null mice. / 02.2018 / PubMed / Full text

CLOCK

Investigating circadian clock gene expression in human tendon biopsies from acute exercise and immobilization studies. / 06.2019 / PubMed / Full text
CLOCK gene polymorphisms and quality of aging in a cohort of nonagenarians - The MUGELLO Study. / 06.02.2019 / PubMed / Full text
Is the aging human ovary still ticking?: Expression of clock-genes in luteinized granulosa cells of young and older women. / 21.11.2018 / PubMed / Full text
Aging and chromatoid body assembly: Are these two physiological events linked? / 07.2018 / PubMed / Full text
CIRCADIAN CLOCK-ASSOCIATED 1 Inhibits Leaf Senescence in [i]Arabidopsis[/i]. / 2018 / PubMed / Full text
Circadian clocks: from stem cells to tissue homeostasis and regeneration. / 01.2018 / PubMed / Full text
Female ClockΔ19/Δ19 mice are protected from the development of age-dependent cardiomyopathy. / 01.02.2018 / PubMed / Full text

CR1

Single Nucleotide Polymorphisms in Alzheimer's Disease Risk Genes Are Associated with Intrinsic Connectivity in Middle Age. / 2020 / PubMed / Full text
The whale shark genome reveals how genomic and physiological properties scale with body size. / 25.08.2020 / PubMed / Full text
Mouse models of Alzheimer's disease cause rarefaction of pial collaterals and increased severity of ischemic stroke. / 05.2019 / PubMed / Full text
Loss of complement regulatory proteins on uninfected erythrocytes in vivax and falciparum malaria anemia. / 15.11.2018 / PubMed / Full text
Recent studies on cellular and molecular mechanisms in Alzheimer's disease: focus on epigenetic factors and histone deacetylase. / 28.03.2018 / PubMed / Full text
Genetic Biomarkers on Age-Related Cognitive Decline. / 2017 / PubMed / Full text
Associations between management practices and major reproductive parameters of Holstein-Friesian replacement heifers. / 01.2018 / PubMed / Full text

CXCL10

Age-related decline of interferon-gamma responses in macrophage impairs satellite cell proliferation and regeneration. / 10.2020 / PubMed / Full text
Neuroprotective effects of targeting BET proteins for degradation with dBET1 in aged mice subjected to ischemic stroke. / 07.2019 / PubMed / Full text
Towards frailty biomarkers: Candidates from genes and pathways regulated in aging and age-related diseases. / 11.2018 / PubMed / Full text
Age-related pro-inflammatory and pro-angiogenic changes in human aqueous humor. / 2018 / PubMed / Full text
Aged Chinese-origin rhesus macaques infected with SIV develop marked viremia in absence of clinical disease, inflammation or cognitive impairment. / 01.02.2018 / PubMed / Full text
Immune senescence and biomarkers profile of Bambuí aged population-based cohort. / 03.2018 / PubMed / Full text
Dysregulation of C-X-C motif ligand 10 during aging and association with cognitive performance. / 03.2018 / PubMed / Full text

DBI

Quantifying cumulative anticholinergic and sedative drug load among US Medicare Beneficiaries. / 01.10.2020 / PubMed / Full text
Drug Burden Index and Cognitive and Physical Function in Aged Care Residents: A Longitudinal Study. / 08.2020 / PubMed / Full text
Using the Drug Burden Index to identify older adults at highest risk for medication-related falls. / 12.06.2020 / PubMed / Full text
Impact of STEADI-Rx: A Community Pharmacy-Based Fall Prevention Intervention. / 08.2020 / PubMed / Full text
Association of Drug Burden Index with grip strength, timed up and go and Barthel index activities of daily living in older adults with intellectual disabilities: an observational cross-sectional study. / 24.06.2019 / PubMed / Full text
Impact of drug burden index on adverse health outcomes in Irish community-dwelling older people: a cohort study. / 29.04.2019 / PubMed / Full text
Dietary Balance Index-07 and the Risk of Anemia in Middle Aged and Elderly People in Southwest China: A Cross Sectional Study. / 31.01.2018 / PubMed / Full text

FAS

Five-year change in maximum tongue pressure and physical function in community-dwelling elderly adults. / 09.2020 / PubMed / Full text
Inhibition of USP7 activity selectively eliminates senescent cells in part via restoration of p53 activity. / 03.2020 / PubMed / Full text
Application of GFR estimation equations in elderly patients with measured GFR below 60 mL/min/1.73 m . / 03.2020 / PubMed / Full text
Dietary methionine increased the lipid accumulation in juvenile tiger puffer Takifugu rubripes. / 04.2019 / PubMed / Full text
Genetic and Environmental Influences on Language Ability in Older Adults: Findings from the Older Australian Twins Study. / 05.2018 / PubMed / Full text
Effects of aging on fat deposition and meat quality in Sheldrake duck. / 01.06.2018 / PubMed / Full text
Impact of sociodemographic variables on executive functions. / 01-03.2017 / PubMed / Full text

MFI

The Influence of the Accelerated Aging Conditions on the Properties of Polyolefin Geogrids Used for Landfill Slope Reinforcement. / 20.08.2020 / PubMed / Full text
Changes in Physical Meat Traits, Protein Solubility, and the Microstructure of Different Beef Muscles during Post-Mortem Aging. / 19.06.2020 / PubMed / Full text
Effect of a low-voltage electrical stimulation on yak meat tenderness during postmortem aging. / 01-12.2020 / PubMed / Full text
Comparative effects of dry-aging and wet-aging on physicochemical properties and digestibility of Hanwoo beef. / 03.2020 / PubMed / Full text
Sexual dimorphism in rat thymic involution: a correlation with thymic oxidative status and inflammation. / 08.2019 / PubMed / Full text
Circulating soluble RAGE and cell surface RAGE on peripheral blood mononuclear cells in healthy children. / 27.06.2018 / PubMed / Full text
The frail fail: Increased mortality and post-operative complications in orthopaedic trauma patients. / 11.2017 / PubMed / Full text

MMP13

Aging aggravates intervertebral disc degeneration by regulating transcription factors toward chondrogenesis. / 02.2020 / PubMed / Full text
EGR1 promotes the cartilage degeneration and hypertrophy by activating the Krüppel-like factor 5 and β-catenin signaling. / 01.09.2019 / PubMed / Full text
Chondrocyte-Specific RUNX2 Overexpression Accelerates Post-traumatic Osteoarthritis Progression in Adult Mice. / 09.2019 / PubMed / Full text
TGF-β type 2 receptor-mediated modulation of the IL-36 family can be therapeutically targeted in osteoarthritis. / 08.05.2019 / PubMed / Full text
Systemic clearance of p16 -positive senescent cells mitigates age-associated intervertebral disc degeneration. / 06.2019 / PubMed / Full text
Design, cyclization, and optimization of MMP13-TIMP1 interaction-derived self-inhibitory peptides against chondrocyte senescence in osteoarthritis. / 01.2019 / PubMed / Full text
Overexpression of microRNA-1470 promotes proliferation and migration, and inhibits senescence of esophageal squamous carcinoma cells. / 12.2017 / PubMed / Full text

MPO

Impaired sleep quality is associated with concurrent elevations in inflammatory markers: are post-menopausal women at greater risk? / 08.07.2019 / PubMed / Full text
Local and systemic effects of aging on acute pancreatitis. / 07.2019 / PubMed / Full text
Inflammatory signatures in older persons with physical frailty and sarcopenia: The frailty "cytokinome" at its core. / 15.07.2019 / PubMed / Full text
Astaxanthin-Rich [i]Haematococcus pluvialis[/i] Algal Hepatic Modulation in D-Galactose-Induced Aging in Rats: Role of Nrf2. / 08.2018 / PubMed / Full text
Effect of β-D-Mannuronic Acid (M2000) on Oxidative Stress Enzymes' Gene Using Healthy Donor Peripheral Blood Mononuclear Cells for Evaluating the Anti-Aging Property. / 2019 / PubMed / Full text
Chlorinative stress in age-related diseases: a literature review. / 2017 / PubMed / Full text
Hippocampal-dependent memory deficit induced by perinatal exposure to polutted eels in middle-aged offspring mice: Sex differential effects. / 05.10.2017 / PubMed / Full text

NOX4

Sestrin2 Attenuates Cellular Senescence by Inhibiting NADPH Oxidase 4 Expression. / 24.11.2020 / PubMed / Full text
NADPH Oxidases and Aging Models of Lung Fibrosis. / 2019 / PubMed / Full text
Age-related distribution and potential role of SNCB in topographically different retinal areas of the common marmoset Callithrix jacchus, including the macula. / 08.2019 / PubMed / Full text
Expression of lipogenic markers is decreased in subcutaneous adipose tissue and adipocytes of older women and is negatively linked to GDF15 expression. / 08.2019 / PubMed / Full text
Redox Imbalance in Idiopathic Pulmonary Fibrosis: A Role for Oxidant Cross-Talk Between NADPH Oxidase Enzymes and Mitochondria. / 10.11.2019 / PubMed / Full text
NADPH oxidase 4 mediates ROS production in radiation-induced senescent cells and promotes migration of inflammatory cells. / 01.2018 / PubMed / Full text
Alternative Splicing of NOX4 in the Failing Human Heart. / 2017 / PubMed / Full text

NPY

Neuropeptide Y Enhances Progerin Clearance and Ameliorates the Senescent Phenotype of Human Hutchinson-Gilford Progeria Syndrome Cells. / 22.05.2020 / PubMed / Full text
Effects of rikkunshito supplementation on resistance to oxidative stress and lifespan in mice. / 03.2020 / PubMed / Full text
Autophagy within the mushroom body protects from synapse aging in a non-cell autonomous manner. / 21.03.2019 / PubMed / Full text
β-Alanine supplementation reduces anxiety and increases neurotrophin expression in both young and older rats. / 02.2019 / PubMed / Full text
Age-related central regulation of orexin and NPY in the short-lived African killifish Nothobranchius furzeri. / 15.05.2019 / PubMed / Full text
Chronic treatment with tributyltin induces sexually dimorphic alterations in the hypothalamic POMC system of adult mice. / 12.2018 / PubMed / Full text
Expression of CGRP neurotransmitter and vascular genesis marker mRNA is age-dependent in superior cervical ganglia of senescence-accelerated prone mice. / 18.01.2018 / PubMed / Full text

OPA1

[i]Sirt3[/i] Deficiency Shortens Life Span and Impairs Cardiac Mitochondrial Function Rescued by [i]Opa1[/i] Gene Transfer. / 12.2019 / PubMed / Full text
Novel role of the SIRT4-OPA1 axis in mitochondrial quality control. / 23.12.2017 / PubMed / Full text
Inhibition of the Fission Machinery Mitigates OPA1 Impairment in Adult Skeletal Muscles. / 15.06.2019 / PubMed / Full text
Increased Degradation Rates in the Components of the Mitochondrial Oxidative Phosphorylation Chain in the Cerebellum of Old Mice. / 2018 / PubMed / Full text
SIRT4 interacts with OPA1 and regulates mitochondrial quality control and mitophagy. / 29.10.2017 / PubMed / Full text
Optic atrophy 1 mediates coenzyme Q-responsive regulation of respiratory complex IV activity in brain mitochondria. / 11.2017 / PubMed / Full text
Dietary supplementation with acetyl-l-carnitine counteracts age-related alterations of mitochondrial biogenesis, dynamics and antioxidant defenses in brain of old rats. / 11.2017 / PubMed / Full text

RET

Effects of resistance exercise training on redox homeostasis in older adults. A systematic review and meta-analysis. / 09.2020 / PubMed / Full text
Effects of an 8-week resistance training intervention on plantar flexor muscle quality and functional capacity in older women: A randomised controlled trial. / 09.2020 / PubMed / Full text
Resistance exercise training promotes fiber type-specific myonuclear adaptations in older adults. / 01.04.2020 / PubMed / Full text
Low skeletal muscle capillarization limits muscle adaptation to resistance exercise training in older adults. / 11.2019 / PubMed / Full text
Resistance Exercise Training as a Primary Countermeasure to Age-Related Chronic Disease. / 2019 / PubMed / Full text
Physical, Chemical, Microstructural and Rheological Properties of Reactive Terpolymer-Modified Bitumen. / 20.03.2019 / PubMed / Full text
Citrulline counteracts overweight- and aging-related effects on adiponectin and leptin gene expression in rat white adipose tissue. / 2015 / PubMed / Full text

SPARC

SPARC Metrics Provide Mobility Smoothness Assessment in Oldest-Old With and Without a History of Falls: A Case Control Study. / 2020 / PubMed / Full text
Reduced fibrillar collagen accumulation in skeletal muscle of secreted protein acidic and rich in cysteine (SPARC)-null mice. / 29.11.2019 / PubMed / Full text
Specific factors in blood from young but not old mice directly promote synapse formation and NMDA-receptor recruitment. / 18.06.2019 / PubMed / Full text
Lifelong aerobic exercise protects against inflammaging and cancer. / 2019 / PubMed / Full text
SPARC is required for the maintenance of glucose homeostasis and insulin secretion in mice. / 31.01.2019 / PubMed / Full text
Aging may negatively impact movement smoothness during stair negotiation. / 08.2018 / PubMed / Full text
The impact of SPARC on age-related cardiac dysfunction and fibrosis in Drosophila. / 08.2018 / PubMed / Full text

TOMM40

A candidate gene study of risk for dementia in older, postmenopausal women: Results from the Women's Health Initiative Memory Study. / 05.2019 / PubMed / Full text
Independent associations of TOMM40 and APOE variants with body mass index. / 02.2019 / PubMed / Full text
Genetics of Human Longevity From Incomplete Data: New Findings From the Long Life Family Study. / 08.10.2018 / PubMed / Full text
Genetic Risk for Age-Related Cognitive Impairment Does Not Predict Cognitive Performance in Middle Age. / 2018 / PubMed / Full text
Apolipoprotein E region molecular signatures of Alzheimer's disease. / 08.2018 / PubMed / Full text
Genetic Variation in FOXO3 is Associated with Self-Rated Health in a Population-Based Sample of Older Individuals. / 08.10.2018 / PubMed / Full text
Genetic variants specific to aging-related verbal memory: Insights from GWASs in a population-based cohort. / 2017 / PubMed / Full text

TST

H S Donors Reverse Age-Related Gastric Malfunction Impaired Due to Fructose-Induced Injury [i]via[/i] CBS, CSE, and TST Expression. / 2020 / PubMed / Full text
Adaptations in mechanical muscle function, muscle morphology, and aerobic power to high-intensity endurance training combined with either traditional or power strength training in older adults: a randomized clinical trial. / 05.2020 / PubMed / Full text
Digital phenotyping by consumer wearables identifies sleep-associated markers of cardiovascular disease risk and biological aging. / 2019 / PubMed / Full text
Objective Sleep Duration in Older Adults: Results From The Irish Longitudinal Study on Ageing. / 01.2020 / PubMed / Full text
Subjective Cognitive Decline and Nighttime Sleep Alterations, a Longitudinal Analysis. / 2019 / PubMed / Full text
Validity Evaluation of the Fitbit Charge2 and the Garmin vivosmart HR+ in Free-Living Environments in an Older Adult Cohort. / 19.06.2019 / PubMed / Full text
Paradoxical effect of testosterone supplementation therapy on cardiac ischemia/reperfusion injury in aged rats. / 07.2019 / PubMed / Full text

UCP2

Potential Role of Leptin in Cardiac Steatosis Induced by Highly Saturated Fat Intake during Adolescence. / 10.2019 / PubMed / Full text
Effect of Initial Aging and High-Fat/High-Fructose Diet on Mitochondrial Bioenergetics and Oxidative Status in Rat Brain. / 11.2019 / PubMed / Full text
Decreased uncoupling protein 2 expression in aging retinal pigment epithelial cells. / 2019 / PubMed / Full text
The Role of Genetic Profile in Functional Performance Adaptations to Exercise Training or Physical Activity: A Systematic Review of the Literature. / 01.08.2019 / PubMed / Full text
G-1 exhibit antidepressant effect, increase of hippocampal ERs expression and improve hippocampal redox status in aged female rats. / 01.02.2019 / PubMed / Full text
Rapamycin increases oxidative metabolism and enhances metabolic flexibility in human cardiac fibroblasts. / 21.06.2018 / PubMed / Full text
Sestrin2 prevents age-related intolerance to post myocardial infarction via AMPK/PGC-1α pathway. / 02.2018 / PubMed / Full text

VDR

25-Hydroxyvitamin D positively regulates periodontal inflammaging via SOCS3/STAT signaling in diabetic mice. / 04.2020 / PubMed / Full text
1,25-Dihydroxyvitamin D protects against age-related osteoporosis by a novel VDR-Ezh2-p16 signal axis. / 02.2020 / PubMed / Full text
Active vitamin D impedes the progression of non-alcoholic fatty liver disease by inhibiting cell senescence in a rat model. / 09.2020 / PubMed / Full text
Age-dependent expression of the vitamin D receptor and the protective effect of vitamin D receptor activation on H O -induced apoptosis in rat intervertebral disc cells. / 06.2019 / PubMed / Full text
Vitamin D Receptor in Muscle Atrophy of Elderly Patients: A Key Element of Osteoporosis-Sarcopenia Connection. / 12.2018 / PubMed / Full text
Reduced vitamin D receptor (VDR) expression and plasma vitamin D levels are associated with aging-related prostate lesions. / 05.2018 / PubMed / Full text
VDR Activation Reduces Proteinuria and High-Glucose-Induced Injury of Kidneys and Podocytes by Regulating Wnt Signaling Pathway. / 2017 / PubMed / Full text

ADAM10

NKG2D Ligand Shedding in Response to Stress: Role of ADAM10. / 2020 / PubMed / Full text
Chronic Mild Stress Modified Epigenetic Mechanisms Leading to Accelerated Senescence and Impaired Cognitive Performance in Mice. / 10.02.2020 / PubMed / Full text
Removal of p75 Neurotrophin Receptor Expression from Cholinergic Basal Forebrain Neurons Reduces Amyloid-β Plaque Deposition and Cognitive Impairment in Aged APP/PS1 Mice. / 07.2019 / PubMed / Full text
11β-HSD1 Inhibition by RL-118 Promotes Autophagy and Correlates with Reduced Oxidative Stress and Inflammation, Enhancing Cognitive Performance in SAMP8 Mouse Model. / 12.2018 / PubMed / Full text
Effects of senescence and angiotensin II on expression and processing of amyloid precursor protein in human cerebral microvascular endothelial cells. / 15.01.2018 / PubMed / Full text
microRNA 221 Targets ADAM10 mRNA and is Downregulated in Alzheimer's Disease. / 2018 / PubMed / Full text

AIP

[Aryl hydrocarbon receptor interacting protein (AIP) in human dermis during aging.] / 2020 / PubMed
Sex-Specific Association between Serum Vitamin D Status and Lipid Profiles: A Cross-Sectional Study of a Middle-Aged and Elderly Chinese Population. / 2020 / PubMed / Full text
The oblique effect: The relationship between profiles of visuospatial preference, cognition, and brain connectomics in older adults. / 12.2019 / PubMed / Full text
A logic of choice: Problematizing the documentary reality of Canadian aging in place policies. / 03.2019 / PubMed / Full text
Enhanced basal late sodium current appears to underlie the age-related prolongation of action potential duration in guinea pig ventricular myocytes. / 14.12.2017 / PubMed / Full text
Building IoT Services for Aging in Place Using Standard-Based IoT Platforms and Heterogeneous IoT Products. / 11.10.2017 / PubMed / Full text

AKT1

MicroRNA-495 enhances chondrocyte apoptosis, senescence and promotes the progression of osteoarthritis by targeting AKT1. / 2019 / PubMed / Full text
Therapeutic and preventive effects of exercise on cardiometabolic parameters in aging and obese rats. / 02.2019 / PubMed / Full text
The biological age linked to oxidative stress modifies breast cancer aggressiveness. / 20.05.2018 / PubMed / Full text
Menopause and adipose tissue: miR-19a-3p is sensitive to hormonal replacement. / 05.01.2018 / PubMed / Full text
SIRT6 histone deacetylase functions as a potential oncogene in human melanoma. / 09.2017 / PubMed / Full text
G protein-coupled receptor kinase 4-induced cellular senescence and its senescence-associated gene expression profiling. / 15.11.2017 / PubMed / Full text

ALDH2

Aldehyde Dehydrogenase 2 (ALDH2) and Aging: Is There a Sensible Link? / 2019 / PubMed / Full text
Appropriate dose of ethanol exerts anti-senescence and anti-atherosclerosis protective effects by activating ALDH2. / 30.04.2019 / PubMed / Full text
Impaired enzymatic reactive aldehyde-detoxifying capacity and glutathione peroxidase activity in the aged human arterial tissue. / 02.2019 / PubMed / Full text
Telomere shortening in alcohol dependence: Roles of alcohol and acetaldehyde. / 02.2019 / PubMed / Full text
Aldehyde dehydrogenase 2 deficiency promotes atherosclerotic plaque instability through accelerating mitochondrial ROS-mediated vascular smooth muscle cell senescence. / 01.07.2019 / PubMed / Full text
ALDH2 mediates the dose-response protection of chronic ethanol against endothelial senescence through SIRT1/p53 pathway. / 12.10.2018 / PubMed / Full text

ARNT

Loss of ARNT in skeletal muscle limits muscle regeneration in aging. / 12.2020 / PubMed / Full text
[Arylhydrocarbon receptor nuclear translocator (ARNT) in human skin during aging.] / 2020 / PubMed
The E3 ubiquitin ligase STUB1 attenuates cell senescence by promoting the ubiquitination and degradation of the core circadian regulator BMAL1. / 03.04.2020 / PubMed / Full text
Deficiency of Bmal1 disrupts the diurnal rhythm of haemostasis. / 04.2019 / PubMed / Full text
Insulin-like growth factor-1 acts as a zeitgeber on hypothalamic circadian clock gene expression via glycogen synthase kinase-3β signaling. / 02.11.2018 / PubMed / Full text
Aging and chromatoid body assembly: Are these two physiological events linked? / 07.2018 / PubMed / Full text

BRCA2

Analysis of somatic mutations identifies signs of selection during in vitro aging of primary dermal fibroblasts. / 12.2019 / PubMed / Full text
Klotho gene polymorphisms are associated with healthy aging and longevity: Evidence from a meta-analysis. / 03.2019 / PubMed / Full text
The replicative senescent mesenchymal stem / stromal cells defect in DNA damage response and anti-oxidative capacity. / 2018 / PubMed / Full text
Faulty BRCA1, BRCA2 genes: how poor is the prognosis? / 10.2017 / PubMed / Full text
Ovarian Aging in Women With BRCA Germline Mutations. / 01.10.2017 / PubMed / Full text
The expected benefit of preventive mastectomy on breast cancer incidence and mortality in BRCA mutation carriers, by age at mastectomy. / 01.2018 / PubMed / Full text

C9

C9orf72 in myeloid cells suppresses STING-induced inflammation. / 09.2020 / PubMed / Full text
Glycine-alanine dipeptide repeats spread rapidly in a repeat length- and age-dependent manner in the fly brain. / 16.12.2019 / PubMed / Full text
Human iPSC-derived astrocytes from ALS patients with mutated C9ORF72 show increased oxidative stress and neurotoxicity. / 12.2019 / PubMed / Full text
Age and Sex-Associated Changes of Complement Activity and Complement Levels in a Healthy Caucasian Population. / 2018 / PubMed / Full text
TMT-Based Quantitative Proteomic Analysis Reveals Proteomic Changes Involved in Longevity. / 07.2019 / PubMed / Full text
C9orf72 Dipeptide Repeats Cause Selective Neurodegeneration and Cell-Autonomous Excitotoxicity in [i]Drosophila[/i] Glutamatergic Neurons. / 29.08.2018 / PubMed / Full text

CA4

Dissociable age and memory relationships with hippocampal subfield volumes in vivo:Data from the Irish Longitudinal Study on Ageing (TILDA). / 29.07.2019 / PubMed / Full text
Aerobic exercise increases hippocampal subfield volumes in younger adults and prevents volume decline in the elderly. / 10.2020 / PubMed / Full text
The Volume of Hippocampal Subfields in Relation to Decline of Memory Recall Across the Adult Lifespan. / 2018 / PubMed / Full text
Alzheimer's Disease Biomarkers Have Distinct Associations with Specific Hippocampal Subfield Volumes. / 2018 / PubMed / Full text
Age-related changes in cortical and subcortical structures of healthy adult brains: A surface-based morphometry study. / 01.2019 / PubMed / Full text
Hippocampal sclerosis, hippocampal neuron loss patterns and TDP-43 in the aged population. / 07.2018 / PubMed / Full text

CBS

Permanent cystathionine-β-Synthase gene knockdown promotes inflammation and oxidative stress in immortalized human adipose-derived mesenchymal stem cells, enhancing their adipogenic capacity. / 02.08.2020 / PubMed / Full text
Cardiovascular phenotype of mice lacking 3-mercaptopyruvate sulfurtransferase. / 06.2020 / PubMed / Full text
Methionine restriction leads to hyperhomocysteinemia and alters hepatic H S production capacity in Fischer-344 rats. / 12.2018 / PubMed / Full text
Human Cord Blood Serum-Derived APP α-Secretase Cleavage Activity is Mediated by C1 Complement. / 04.2018 / PubMed / Full text
Dietary and Endocrine Regulation of Endogenous Hydrogen Sulfide Production: Implications for Longevity. / 01.06.2018 / PubMed / Full text
Nitration-mediated deficiency of cystathionine β-synthase activity accelerates the progression of hyperhomocysteinemia. / 12.2017 / PubMed / Full text

CD47

Aging-associated changes in CD47 arrangement and interaction with thrombospondin-1 on red blood cells visualized by super-resolution imaging. / 10.2020 / PubMed / Full text
CD47 Promotes Age-Associated Deterioration in Angiogenesis, Blood Flow and Glucose Homeostasis. / 15.07.2020 / PubMed / Full text
Unique Spatial Immune Profiling in Pancreatic Ductal Adenocarcinoma with Enrichment of Exhausted and Senescent T Cells and Diffused CD47-SIRPα Expression. / 07.07.2020 / PubMed / Full text
Diabetes Impairs Angiogenesis and Induces Endothelial Cell Senescence by Up-Regulating Thrombospondin-CD47-Dependent Signaling. / 04.02.2019 / PubMed / Full text
Loss of complement regulatory proteins on uninfected erythrocytes in vivax and falciparum malaria anemia. / 15.11.2018 / PubMed / Full text
The matricellular protein TSP1 promotes human and mouse endothelial cell senescence through CD47 and Nox1. / 17.10.2017 / PubMed / Full text

CD5

Comparative proteomic analysis identifies biomarkers for renal aging. / 06.11.2020 / PubMed / Full text
Crucial Role of Increased Arid3a at the Pre-B and Immature B Cell Stages for B1a Cell Generation. / 2019 / PubMed / Full text
Correlation of cell-surface CD8 levels with function, phenotype and transcriptome of naive CD8 T cells. / 04.2019 / PubMed / Full text
Early Generated B-1-Derived B Cells Have the Capacity To Progress To Become Mantle Cell Lymphoma-like Neoplasia in Aged Mice. / 15.07.2018 / PubMed / Full text
Age-related changes in mRNA expression of selected surface receptors in lymphocytes of dairy calves. / 03.2018 / PubMed / Full text
Altered marginal zone and innate-like B cells in aged senescence-accelerated SAMP8 mice with defective IgG1 responses. / 17.08.2017 / PubMed / Full text

CPM

Test-Retest Instability of Temporal Summation and Conditioned Pain Modulation Measures in Older Adults. / 21.10.2020 / PubMed / Full text
Age does not affect sex effect of conditioned pain modulation of pressure and thermal pain across 2 conditioning stimuli. / 01-02.2020 / PubMed / Full text
The Decline of Endogenous Pain Modulation With Aging: A Meta-Analysis of Temporal Summation and Conditioned Pain Modulation. / 05-06.2020 / PubMed / Full text
A keratinocyte and integrated fibroblast culture model for studying particulate matter-induced skin lesions and therapeutic intervention of fucosterol. / 15.09.2019 / PubMed / Full text
Daily physical activity patterns among aging workers: the Finnish Retirement and Aging Study (FIREA). / 01.2019 / PubMed / Full text
Resting-state functional connectivity predicts neuroticism and extraversion in novel individuals. / 01.02.2018 / PubMed / Full text

CX3CL1

Two forms of CX3CL1 display differential activity and rescue cognitive deficits in CX3CL1 knockout mice. / 14.05.2020 / PubMed / Full text
Expression of pro- and anti-inflammatory cytokines and chemokines during the ovulatory cycle and effects of aging on their expression in the uterine mucosa of laying hens. / 11.2018 / PubMed / Full text
Towards frailty biomarkers: Candidates from genes and pathways regulated in aging and age-related diseases. / 11.2018 / PubMed / Full text
Surgical Trauma Exacerbates Cognitive Deficits and Neuroinflammation in Aged Rats: The Role of CX3CL1-CX3CR1 Signaling. / 01.08.2018 / PubMed / Full text
Repopulating retinal microglia restore endogenous organization and function under CX3CL1-CX3CR1 regulation. / 03.2018 / PubMed / Full text
Microglia and Aging: The Role of the TREM2-DAP12 and CX3CL1-CX3CR1 Axes. / 22.01.2018 / PubMed / Full text

CXCL2

Inflammatory and Senescent Phenotype of Pancreatic Stellate Cells Induced by Sqstm1 Downregulation Facilitates Pancreatic Cancer Progression. / 2019 / PubMed / Full text
Long-term every-other-day administration of DMAMCL has little effect on aging and age-associated physiological decline in mice. / 02.05.2019 / PubMed / Full text
A Neutrophil Timer Coordinates Immune Defense and Vascular Protection. / 19.02.2019 / PubMed / Full text
Excessive neutrophil levels in the lung underlie the age-associated increase in influenza mortality. / 03.2019 / PubMed / Full text
Time-Dependent Changes in Local and Serum Levels of Inflammatory Cytokines as Markers for Incised Wound Aging of Skeletal Muscles. / 05.2018 / PubMed / Full text
Tumor microenvironment in functional adrenocortical adenomas: immune cell infiltration in cortisol-producing adrenocortical adenoma. / 07.2018 / PubMed / Full text

CXCR2

CXCL5-CXCR2 signaling is a senescence-associated secretory phenotype in preimplantation embryos. / 10.2020 / PubMed / Full text
Senescence in Wound Repair: Emerging Strategies to Target Chronic Healing Wounds. / 2020 / PubMed / Full text
Cellular Senescence in Diabetic Wounds: When Too Many Retirees Stress the System. / 05.2019 / PubMed / Full text
Elevated Local Senescence in Diabetic Wound Healing Is Linked to Pathological Repair via CXCR2. / 05.2019 / PubMed / Full text
A Neutrophil Timer Coordinates Immune Defense and Vascular Protection. / 19.02.2019 / PubMed / Full text
Chronic Resveratrol Treatment Reduces the Pro-angiogenic Effect of Human Fibroblast "Senescent-Associated Secretory Phenotype" on Endothelial Colony-Forming Cells: The Role of IL8. / 23.04.2019 / PubMed / Full text

DPP4

Age-Dependent Assessment of Genes Involved in Cellular Senescence, Telomere, and Mitochondrial Pathways in Human Lung Tissue of Smokers, COPD, and IPF: Associations With SARS-CoV-2 COVID-19 ACE2-TMPRSS2-Furin-DPP4 Axis. / 2020 / PubMed / Full text
Dipeptidyl peptidase-4 inhibition improves endothelial senescence by activating AMPK/SIRT1/Nrf2 signaling pathway. / 07.2020 / PubMed / Full text
Molecular crosstalk between Y5 receptor and neuropeptide Y drives liver cancer. / 01.05.2020 / PubMed / Full text
Dose rectification of an imbalance between DPP4 and GLP-1 ameliorates chronic stress-related vascular aging and atherosclerosis? / 05.2018 / PubMed / Full text
Chronic Psychological Stress Accelerates Vascular Senescence and Impairs Ischemia-Induced Neovascularization: The Role of Dipeptidyl Peptidase-4/Glucagon-Like Peptide-1-Adiponectin Axis. / 28.09.2017 / PubMed / Full text
Identification of senescent cell surface targetable protein DPP4. / 01.08.2017 / PubMed / Full text

DRD2

Cortical thickness mediates the relationship between DRD2 C957T polymorphism and executive function across the adult lifespan. / 11.11.2020 / PubMed / Full text
The relationship of age and DRD2 polymorphisms to frontostriatal brain activity and working memory performance. / 12.2019 / PubMed / Full text
Dopamine-Related Genotypes and Physical Activity Change During an Intervention: The Lifestyle Interventions and Independence for Elders Study. / 07.2018 / PubMed / Full text
Influence of the DRD2/ANKK1 Taq1A polymorphism on caudate volume in older adults without dementia. / 07.2018 / PubMed / Full text
FTO affects food cravings and interacts with age to influence age-related decline in food cravings. / 01.08.2018 / PubMed / Full text
The DRD2 Taq1A A1 Allele May Magnify the Risk of Alzheimer's in Aging African-Americans. / 07.2018 / PubMed / Full text

EDA

Interplay between aging, lung inflammation/remodeling, and fibronectin EDA in lung cancer progression. / 01.12.2020 / PubMed / Full text
Arousal Detection in Elderly People from Electrodermal Activity Using Musical Stimuli. / 25.08.2020 / PubMed / Full text
The structure of agricultural microplastics (PT, PU and UF) and their sorption capacities for PAHs and PHE derivates under various salinity and oxidation treatments. / 02.2020 / PubMed / Full text
Effect of storage on quality parameters and phenolic content of Italian extra-virgin olive oils. / 01.2020 / PubMed / Full text
Fibronectin Containing Extra Domain A Induces Plaque Destabilization in the Innominate Artery of Aged Apolipoprotein E-Deficient Mice. / 03.2018 / PubMed / Full text
An Extract from the Plant [i]Deschampsia antarctica[/i] Protects Fibroblasts from Senescence Induced by Hydrogen Peroxide. / 2017 / PubMed / Full text

FAP

Rapamycin Extends Life Span in Apc Colon Cancer FAP Model. / 15.09.2020 / PubMed / Full text
Exercise enhances skeletal muscle regeneration by promoting senescence in fibro-adipogenic progenitors. / 14.02.2020 / PubMed / Full text
Control of Muscle Fibro-Adipogenic Progenitors by Myogenic Lineage is Altered in Aging and Duchenne Muscular Dystrophy. / 2019 / PubMed / Full text
Higher serum levels of fibroblast growth factor 21 in old patients with cachexia. / 07-08.2019 / PubMed / Full text
Aging Disrupts Muscle Stem Cell Function by Impairing Matricellular WISP1 Secretion from Fibro-Adipogenic Progenitors. / 07.03.2019 / PubMed / Full text
Odd skipped-related 1 identifies a population of embryonic fibro-adipogenic progenitors regulating myogenesis during limb development. / 31.10.2017 / PubMed / Full text

FH

Genetic Factors of Alzheimer's Disease Modulate How Diet is Associated with Long-Term Cognitive Trajectories: A UK Biobank Study. / 2020 / PubMed / Full text
Volumetric alterations in the hippocampal subfields of subjects at increased risk of dementia. / 07.2020 / PubMed / Full text
Macroscopic hematuria as a risk factor for hypertension in ageing people with hemophilia and a family history of hypertension. / 02.2020 / PubMed / Full text
LDL Receptor Deficiency Does not Alter Brain Amyloid-β Levels but Causes an Exacerbation of Apoptosis. / 2020 / PubMed / Full text
Sex differences in cholesterol levels from birth to 19 years of age may lead to increased cholesterol burden in females with FH. / 05-06.2018 / PubMed / Full text
Association between lipoprotein (a) and proprotein convertase substilisin/kexin type 9 in patients with heterozygous familial hypercholesterolemia: A case-control study. / 02.2018 / PubMed / Full text

FNDC5

Irisin Correlates Positively With BMD in a Cohort of Older Adult Patients and Downregulates the Senescent Marker p21 in Osteoblasts. / 14.10.2020 / PubMed / Full text
[Investigation of signal molecules in saliva: prospects of application for diagnostics of myocardial infarction and the aging rate of different age people.] / 2019 / PubMed
Mechanistic complexities of bone loss in Alzheimer's disease: a review. / 01.2020 / PubMed / Full text
Towards frailty biomarkers: Candidates from genes and pathways regulated in aging and age-related diseases. / 11.2018 / PubMed / Full text
Exercise Training Protects Against Aging-Induced Cognitive Dysfunction via Activation of the Hippocampal PGC-1α/FNDC5/BDNF Pathway. / 09.2018 / PubMed / Full text
Epistasis, physical capacity-related genes and exceptional longevity: FNDC5 gene interactions with candidate genes FOXOA3 and APOE. / 14.11.2017 / PubMed / Full text

FOXO4

FOXO4-DRI alleviates age-related testosterone secretion insufficiency by targeting senescent Leydig cells in aged mice. / 20.01.2020 / PubMed / Full text
Introduction to FOXO Biology. / 2019 / PubMed / Full text
Regulation of cellular senescence via the FOXO4-p53 axis. / 06.2018 / PubMed / Full text
Cellular senescence in the aging and diseased kidney. / 03.2018 / PubMed / Full text
[Molecular regulative mechanisms of aging and interventional effects of Chinese herbal medicine]. / 08.2017 / PubMed / Full text
FOXO Transcriptional Factors and Long-Term Living. / 2017 / PubMed / Full text

FST

Comorbid sensorimotor and emotional profiles in the forced swim test immobility and predictive value of a single assay in very old female mice. / 06.2019 / PubMed / Full text
Structure-function multi-scale connectomics reveals a major role of the fronto-striato-thalamic circuit in brain aging. / 12.2018 / PubMed / Full text
Exercise related anxiety-like behaviours are mediated by TNF receptor signaling, but not depression-like behaviours. / 15.09.2018 / PubMed / Full text
Preliminary Data on Some Behavioral Changes Induced by Short-Term Intraperitoneal Oxytocin Administration in Aged Rats. / 03.2018 / PubMed / Full text
Proteomic profiling of follicle fluids after superstimulation in one-month-old lambs. / 02.2018 / PubMed / Full text
Desipramine rescues age-related phenotypes in depression-like rats induced by chronic mild stress. / 01.11.2017 / PubMed / Full text

FTO

Decreased expression of m A demethylase FTO in ovarian aging. / 22.11.2020 / PubMed / Full text
ALKB-8, a 2-Oxoglutarate-Dependent Dioxygenase and S-Adenosine Methionine-Dependent Methyltransferase Modulates Metabolic Events Linked to Lysosome-Related Organelles and Aging in C. elegans. / 2018 / PubMed
The GDF11-FTO-PPARγ axis controls the shift of osteoporotic MSC fate to adipocyte and inhibits bone formation during osteoporosis. / 12.2018 / PubMed / Full text
Genome-wide meta-analysis of macronutrient intake of 91,114 European ancestry participants from the cohorts for heart and aging research in genomic epidemiology consortium. / 12.2019 / PubMed / Full text
FTO is involved in Alzheimer's disease by targeting TSC1-mTOR-Tau signaling. / 25.03.2018 / PubMed / Full text
FTO affects food cravings and interacts with age to influence age-related decline in food cravings. / 01.08.2018 / PubMed / Full text

GATA4

Epigenetics and Vascular Senescence-Potential New Therapeutic Targets? / 2020 / PubMed / Full text
Prolonged treatment with Y-27632 promotes the senescence of primary human dermal fibroblasts by increasing the expression of IGFBP-5 and transforming them into a CAF-like phenotype. / 25.08.2020 / PubMed / Full text
The zinc finger protein GATA4 induces mesenchymal-to-epithelial transition and cellular senescence through the nuclear factor-κB pathway in hepatocellular carcinoma. / 12.2019 / PubMed / Full text
Isolation, Characterization, and Differentiation of Cardiac Stem Cells from the Adult Mouse Heart. / 07.01.2019 / PubMed / Full text
GATA Regulation and Function During the Ovarian Life Cycle. / 2018 / PubMed / Full text
Genetic interrogation of replicative senescence uncovers a dual role for USP28 in coordinating the p53 and GATA4 branches of the senescence program. / 01.10.2017 / PubMed / Full text

GDNF

GFR-α1 Expression in Substantia Nigra Increases Bilaterally Following Unilateral Striatal GDNF in Aged Rats and Attenuates Nigral Tyrosine Hydroxylase Loss Following 6-OHDA Nigrostriatal Lesion. / 16.10.2019 / PubMed / Full text
The Gender-Biased Effects of Intranasal MPTP Administration on Anhedonic- and Depressive-Like Behaviors in C57BL/6 Mice: the Role of Neurotrophic Factors. / 11.2018 / PubMed / Full text
Analysis of neurotrophic and antioxidant factors related to midbrain dopamine neuronal loss and brain inflammation in the cerebrospinal fluid of the elderly. / 09.2018 / PubMed / Full text
Glial cell line-derived neurotrophic factor (GDNF) attenuates the peripheral neuromuscular dysfunction without inhibiting the activation of spinal microglia/monocyte. / 09.05.2018 / PubMed / Full text
Aging-related limit of exercise efficacy on motor decline. / 2017 / PubMed / Full text
The Noradrenergic System of Aged GDNF Heterozygous Mice. / 04.2003 / PubMed / Full text

HDAC1

HDAC1 modulates OGG1-initiated oxidative DNA damage repair in the aging brain and Alzheimer's disease. / 18.05.2020 / PubMed / Full text
Loss of genomic integrity induced by lysosphingolipid imbalance drives ageing in the heart. / 04.2019 / PubMed / Full text
Re-exploring the core genes and modules in the human frontal cortex during chronological aging: insights from network-based analysis of transcriptomic studies. / 20.10.2018 / PubMed / Full text
Acetylation of PGC1α by Histone Deacetylase 1 Downregulation Is Implicated in Radiation-Induced Senescence of Brain Endothelial Cells. / 16.05.2019 / PubMed / Full text
Histone deacetylase 1 expression is inversely correlated with age in the short-lived fish Nothobranchius furzeri. / 09.2018 / PubMed / Full text
Ablation of toll-like receptor 4 attenuates aging-induced myocardial remodeling and contractile dysfunction through NCoRI-HDAC1-mediated regulation of autophagy. / 06.2018 / PubMed / Full text

HDAC2

EEF1A1 deacetylation enables transcriptional activation of remyelination. / 09.07.2020 / PubMed / Full text
Endothelial toll-like receptor 4 maintains lung integrity via epigenetic suppression of p16 . / 06.2019 / PubMed / Full text
Budesonide, Aclidinium and Formoterol in combination limit inflammaging processes in bronchial epithelial cells exposed to cigarette smoke. / 04.2019 / PubMed / Full text
HDAC3 Regulates the Transition to the Homeostatic Myelinating Schwann Cell State. / 04.12.2018 / PubMed / Full text
Altered modulation of lamin A/C-HDAC2 interaction and p21 expression during oxidative stress response in HGPS. / 10.2018 / PubMed / Full text
Histone deacetylase 1 expression is inversely correlated with age in the short-lived fish Nothobranchius furzeri. / 09.2018 / PubMed / Full text

IDH2

Reactive oxygen species-mediated senescence is accelerated by inhibiting Cdk2 in Idh2-deficient conditions. / 10.09.2019 / PubMed / Full text
Augmentation of cellular NAD by NQO1 enzymatic action improves age-related hearing impairment. / 10.2019 / PubMed / Full text
Improving Treatment for Myelodysplastic Syndromes Patients. / 25.10.2018 / PubMed / Full text
Loss of IDH2 Accelerates Age-related Hearing Loss in Male Mice. / 22.03.2018 / PubMed / Full text
IDH2-deficient mice develop spinal deformities with aging. / 17.07.2018 / PubMed / Full text
Idh2 deficiency accelerates renal dysfunction in aged mice. / 04.11.2017 / PubMed / Full text

IGFBP3

Cellular and Molecular Biomarkers Indicate Premature Aging in Pseudoxanthoma Elasticum Patients. / 05.2020 / PubMed / Full text
Paracrine senescence of human endometrial mesenchymal stem cells: a role for the insulin-like growth factor binding protein 3. / 17.01.2020 / PubMed / Full text
Are There Common Mechanisms Between the Hutchinson-Gilford Progeria Syndrome and Natural Aging? / 2019 / PubMed / Full text
Blunted satellite cell response is associated with dysregulated IGF-1 expression after exercise with age. / 10.2018 / PubMed / Full text
Systemic analysis of gene expression profiles in porcine granulosa cells during aging. / 14.11.2017 / PubMed / Full text
G protein-coupled receptor kinase 4-induced cellular senescence and its senescence-associated gene expression profiling. / 15.11.2017 / PubMed / Full text

LBR

Lamin B receptor: role on chromatin structure, cellular senescence and possibly aging. / 31.07.2020 / PubMed / Full text
The impact of age beyond ploidy: outcome data from 8175 euploid single embryo transfers. / 03.2020 / PubMed / Full text
The role of lamin B receptor in the regulation of senescence-associated secretory phenotype (SASP). / 01.05.2020 / PubMed / Full text
Lamin B receptor plays a key role in cellular senescence induced by inhibition of the proteasome. / 11.12.2019 / PubMed / Full text
Lamin B receptor (LBR) is involved in the induction of cellular senescence in human cells. / 03.2019 / PubMed / Full text
Consequences of Lamin B1 and Lamin B Receptor Downregulation in Senescence. / 06.02.2018 / PubMed / Full text

LOX

12-LOX catalyzes the oxidation of 2-arachidonoyl-lysolipids in platelets generating eicosanoid-lysolipids that are attenuated by iPLA γ knockout. / 17.04.2020 / PubMed / Full text
Rice DNA-Binding One Zinc Finger 24 (OsDOF24) Delays Leaf Senescence in a Jasmonate-Mediated Pathway. / 01.09.2019 / PubMed / Full text
An Adult Drosophila Glioma Model for Studying Pathometabolic Pathways of Gliomagenesis. / 06.2019 / PubMed / Full text
Suppression of LOX activity enhanced seed vigour and longevity of tobacco ([i]Nicotiana tabacum[/i] L.) seeds during storage. / 2018 / PubMed / Full text
Dermal Collagen Stabilization by Polyphenols and Spray Drying as an Encapsulation Strategy. / 2018 / PubMed / Full text
Oxygenation of polyunsaturated fatty acids and oxidative stress within blood platelets. / 06.2018 / PubMed / Full text

MBP

Demyelination associated with chronic arsenic exposure in Wistar rats. / 15.04.2020 / PubMed / Full text
Natural killer cells as participants in pathogenesis of rat experimental autoimmune encephalomyelitis (EAE): lessons from research on rats with distinct age and strain. / 2019 / PubMed / Full text
Whey protein concentrate supplementation protects rat brain against aging-induced oxidative stress and neurodegeneration. / 05.2018 / PubMed / Full text
Strain specificities in age-related changes in mechanisms promoting and controlling rat spinal cord damage in experimental autoimmune encephalomyelitis. / 01.2018 / PubMed / Full text
Age-dependent differences in myelin basic protein expression in the hippocampus of young, adult and aged gerbils. / 09.2017 / PubMed / Full text
Schwann Cell Phenotype Changes in Aging Human Dental Pulp. / 03.2018 / PubMed / Full text

MMP1

Reacquisition of a spindle cell shape does not lead to the restoration of a youthful state in senescent human skin fibroblasts. / 12.2020 / PubMed / Full text
A novel multifunctional skin care formulation with a unique blend of antipollution, brightening and antiaging active complexes. / 06.2020 / PubMed / Full text
Seno-destructive smooth muscle cells in the ascending aorta of patients with bicuspid aortic valve disease. / 05.2019 / PubMed / Full text
Senescent dermal fibroblasts negatively influence fibroblast extracellular matrix-related gene expression partly via secretion of complement factor D. / 07.2019 / PubMed / Full text
Ginsenoside Rh2 Ameliorates Doxorubicin-Induced Senescence Bystander Effect in Breast Carcinoma Cell MDA-MB-231 and Normal Epithelial Cell MCF-10A. / 12.03.2019 / PubMed / Full text
Retinoic acid promotes in vitro follicle activation in the cat ovary by regulating expression of matrix metalloproteinase 9. / 2018 / PubMed / Full text

MMP9

EGR1 promotes the cartilage degeneration and hypertrophy by activating the Krüppel-like factor 5 and β-catenin signaling. / 01.09.2019 / PubMed / Full text
[Effect of saponins extracted from Panax japonicas on inhibiting myocardial fibrosis by TGF-β1/Smad3 signaling pathway in aging rats]. / 11.2018 / PubMed / Full text
Retinoic acid promotes in vitro follicle activation in the cat ovary by regulating expression of matrix metalloproteinase 9. / 2018 / PubMed / Full text
Oxidative stress induces p38MAPK-dependent senescence in the feto-maternal interface cells. / 07.2018 / PubMed / Full text
Activation of DNA demethylases attenuates aging-associated arterial stiffening and hypertension. / 08.2018 / PubMed / Full text
Fibronectin Containing Extra Domain A Induces Plaque Destabilization in the Innominate Artery of Aged Apolipoprotein E-Deficient Mice. / 03.2018 / PubMed / Full text

OGG1

Advanced Age Is Associated with Iron Dyshomeostasis and Mitochondrial DNA Damage in Human Skeletal Muscle. / 27.11.2019 / PubMed / Full text
8-Oxoguanine accumulation in aged female brain impairs neurogenesis in the dentate gyrus and major island of Calleja, causing sexually dimorphic phenotypes. / 09.2019 / PubMed / Full text
Sirt3 mediates the protective effect of hydrogen in inhibiting ROS-induced retinal senescence. / 01.05.2019 / PubMed / Full text
[Protective effect of Wuzi Yanzong recipe on testicular DNA oxidative damage in natural ageing rats]. / 07.2018 / PubMed / Full text
The replicative senescent mesenchymal stem / stromal cells defect in DNA damage response and anti-oxidative capacity. / 2018 / PubMed / Full text
DNA damage and telomere length shortening in the peripheral blood leukocytes of 20 years SM-exposed veterans. / 08.2018 / PubMed / Full text

PAM

Relationship between patient activation measurement and self-rated health in patients with chronic diseases. / 04.11.2020 / PubMed / Full text
Reversal of Age-Related Neuronal Atrophy by α5-GABAA Receptor Positive Allosteric Modulation. / 17.10.2020 / PubMed / Full text
The ratio of prematurely aging to non-prematurely aging mice cohabiting, conditions their behavior, immunity and lifespan. / 15.06.2020 / PubMed / Full text
Oxidative-Inflammatory Stress in Immune Cells from Adult Mice with Premature Aging. / 12.02.2019 / PubMed / Full text
Social environment improves immune function and redox state in several organs from prematurely aging female mice and increases their lifespan. / 02.2019 / PubMed / Full text
Synergistic enhancing-memory effect of donepezil and S 47445, an AMPA positive allosteric modulator, in middle-aged and aged mice. / 03.2018 / PubMed / Full text

POMC

Gpr17 deficiency in POMC neurons ameliorates the metabolic derangements caused by long-term high-fat diet feeding. / 14.10.2019 / PubMed / Full text
Congenital Hypothyroidism is Associated With Impairment of the Leptin Signaling Pathway in the Hypothalamus in Male Wistar Animals in Adult Life. / 05.2019 / PubMed / Full text
Age-dependent decline of hypothalamic HIF2α in response to insulin and its contribution to advanced age-associated metabolic disorders in mice. / 29.03.2019 / PubMed / Full text
Prss56 expression in the rodent hypothalamus: Inverse correlation with pro-opiomelanocortin suggests oscillatory gene expression in adult rat tanycytes. / 15.10.2018 / PubMed / Full text
Chronic treatment with tributyltin induces sexually dimorphic alterations in the hypothalamic POMC system of adult mice. / 12.2018 / PubMed / Full text
Overexpression of WNK1 in POMC-expressing neurons reduces weigh gain via WNK4-mediated degradation of Kir6.2. / 10.2018 / PubMed / Full text

RIPK1

Casein kinase 1G2 suppresses necroptosis-promoted testis aging by inhibiting receptor-interacting kinase 3. / 18.11.2020 / PubMed / Full text
Crucial role of the terminal complement complex in chondrocyte death and hypertrophy after cartilage trauma. / 05.2020 / PubMed / Full text
RIP kinases as modulators of inflammation and immunity. / 09.2018 / PubMed / Full text
TBK1 Suppresses RIPK1-Driven Apoptosis and Inflammation during Development and in Aging. / 06.09.2018 / PubMed / Full text
Necroptosis increases with age and is reduced by dietary restriction. / 08.2018 / PubMed / Full text
RIPK1-RIPK3-MLKL-dependent necrosis promotes the aging of mouse male reproductive system. / 15.08.2017 / PubMed / Full text

S100B

Aging protects rat cortical slices against to oxygen-glucose deprivation induced damage. / 12.2020 / PubMed / Full text
The Role of S100B in Aerobic Training Efficacy in Older Adults with Mild Vascular Cognitive Impairment: Secondary Analysis of a Randomized Controlled Trial. / 01.07.2019 / PubMed / Full text
Changes in mechanoreceptors in rabbits' anterior cruciate ligaments with age. / 06.2019 / PubMed / Full text
Towards frailty biomarkers: Candidates from genes and pathways regulated in aging and age-related diseases. / 11.2018 / PubMed / Full text
DNA methylation analysis on purified neurons and glia dissects age and Alzheimer's disease-specific changes in the human cortex. / 25.07.2018 / PubMed / Full text
Proteome profiling in the hippocampus, medial prefrontal cortex, and striatum of aging rat. / 01.10.2018 / PubMed / Full text

SIRT4

Novel role of the SIRT4-OPA1 axis in mitochondrial quality control. / 23.12.2017 / PubMed / Full text
Mitochondrial Function, Metabolic Regulation, and Human Disease Viewed through the Prism of Sirtuin 4 (SIRT4) Functions. / 03.05.2019 / PubMed / Full text
Loss of mitochondrial SIRT4 shortens lifespan and leads to a decline in physical activity. / 06.2018 / PubMed
SIRT4 is essential for metabolic control and meiotic structure during mouse oocyte maturation. / 08.2018 / PubMed / Full text
Differential gene expression of sirtuins between somatotropinomas and nonfunctioning pituitary adenomas. / 08.2018 / PubMed / Full text
SIRT4 interacts with OPA1 and regulates mitochondrial quality control and mitophagy. / 29.10.2017 / PubMed / Full text

SIRT7

SIRT7 antagonizes human stem cell aging as a heterochromatin stabilizer. / 07.2020 / PubMed / Full text
Spatio-temporal expression profile of sirtuins during aging of the annual fish Nothobranchius furzeri. / 09.2019 / PubMed / Full text
Advances in Cellular Characterization of the Sirtuin Isoform, SIRT7. / 2018 / PubMed / Full text
The epigenetic regulator SIRT7 guards against mammalian cellular senescence induced by ribosomal DNA instability. / 13.07.2018 / PubMed / Full text
Differential gene expression of sirtuins between somatotropinomas and nonfunctioning pituitary adenomas. / 08.2018 / PubMed / Full text
Analysis of Polymorphisms in 59 Potential Candidate Genes for Association With Human Longevity. / 08.10.2018 / PubMed / Full text

SQSTM1

The selective autophagy receptor SQSTM1/p62 improves lifespan and proteostasis in an evolutionarily conserved manner. / 04.2020 / PubMed / Full text
SIRT2 functions in aging, autophagy, and apoptosis in post-maturation bovine oocytes. / 01.09.2019 / PubMed / Full text
A pH probe inhibits senescence in mesenchymal stem cells. / 07.12.2018 / PubMed / Full text
The ATG5-binding and coiled coil domains of ATG16L1 maintain autophagy and tissue homeostasis in mice independently of the WD domain required for LC3-associated phagocytosis. / 04.2019 / PubMed / Full text
Systemic overexpression of SQSTM1/p62 accelerates disease onset in a SOD1 -expressing ALS mouse model. / 29.05.2018 / PubMed / Full text
SIRT6 histone deacetylase functions as a potential oncogene in human melanoma. / 09.2017 / PubMed / Full text

TLR9

Age-Associated B Cells. / 26.04.2020 / PubMed / Full text
Inhibition of TLR9 attenuates skeletal muscle fibrosis in aged sarcopenic mice via the p53/SIRT1 pathway. / 15.07.2019 / PubMed / Full text
Novel molecular mechanisms for the adaptogenic effects of herbal extracts on isolated brain cells using systems biology. / 15.11.2018 / PubMed / Full text
B cell responses to apoptotic cells in MFG-E8-/- mice. / 2018 / PubMed / Full text
Sirtuin 1-Chromatin-Binding Dynamics Points to a Common Mechanism Regulating Inflammatory Targets in SIV Infection and in the Aging Brain. / 06.2018 / PubMed / Full text
Decreased NLRP3 inflammasome expression in aged lung may contribute to increased susceptibility to secondary Streptococcus pneumoniae infection. / 05.2018 / PubMed / Full text

TPR

Catalytic Performances of Cu/MCM-22 Zeolites with Different Cu Loadings in NH -SCR. / 30.10.2020 / PubMed / Full text
Do traits of plant species predict the efficacy of species distribution models for finding new occurrences? / 06.2020 / PubMed / Full text
In-situ modified the surface of Pt-doped perovskite catalyst for soot oxidation. / 05.02.2020 / PubMed / Full text
Nuclear pore density controls heterochromatin reorganization during senescence. / 01.02.2019 / PubMed / Full text
Spontaneous mutations in [i]CYC8[/i] and [i]MIG1[/i] suppress the short chronological lifespan of budding yeast lacking SNF1/AMPK. / 19.02.2018 / PubMed / Full text
Genome-wide association study and annotating candidate gene networks affecting age at first calving in Nellore cattle. / 12.2017 / PubMed / Full text

TXNIP

Panax notoginseng saponins attenuate neuroinflammation through TXNIP-mediated NLRP3 inflammasome activation in aging rats. / 10.11.2020 / PubMed / Full text
Redox homeostasis and cell cycle activation mediate beta-cell mass expansion in aged, diabetes-prone mice under metabolic stress conditions: Role of thioredoxin-interacting protein (TXNIP). / 07.10.2020 / PubMed / Full text
[Effect of diabetic induced thioredoxin interacting protein (TXNIP) on islet cell senescence]. / 03.2020 / PubMed / Full text
PRMT5-TRIM21 interaction regulates the senescence of osteosarcoma cells by targeting the TXNIP/p21 axis. / 05.02.2020 / PubMed / Full text
TXNIP regulates AKT-mediated cellular senescence by direct interaction under glucose-mediated metabolic stress. / 12.2018 / PubMed / Full text
Enhanced expression of thioredoxin-interacting-protein regulates oxidative DNA damage and aging. / 07.2018 / PubMed / Full text

VIP

Alterations in Intrinsic and Synaptic Properties of Hippocampal CA1 VIP Interneurons During Aging. / 2020 / PubMed / Full text
Nutrition and exercise interventions could ameliorate age-related cognitive decline: a meta-analysis of randomized controlled trials. / 14.10.2020 / PubMed / Full text
Neuropeptide changes in the suprachiasmatic nucleus are associated with the development of hypertension. / 08.2019 / PubMed / Full text
The Alabama VIP older driver study rationale and design: examining the relationship between vision impairment and driving using naturalistic driving techniques. / 07.02.2018 / PubMed / Full text
Aging-Induced Modulation of Pituitary Adenylate Cyclase-Activating Peptide- and Vasoactive Intestinal Peptide-Induced Vasomotor Responses in the Arteries of Mice. / 2017 / PubMed / Full text
Ontogeny of Circadian Rhythms and Synchrony in the Suprachiasmatic Nucleus. / 07.02.2018 / PubMed / Full text

ABO

Allelic distribution of [i]ABO[/i] gene in Chinese centenarians. / 09.2020 / PubMed / Full text
Genetically Determined ABO Blood Group and its Associations With Health and Disease. / 03.2020 / PubMed / Full text
Plasma proteomic and autoantibody profiles reveal the proteomic characteristics involved in longevity families in Bama, China. / 2019 / PubMed / Full text
Recipients with blood group A associated with longer survival rates in cardiac valvular bioprostheses. / 04.2019 / PubMed / Full text
ABO blood group polymorphism has an impact on prostate, kidney and bladder cancer in association with longevity. / 07.2018 / PubMed / Full text

ACR

Progenitor cell niche senescence reflects pathology of the parotid salivary gland in primary Sjögren's syndrome. / 01.10.2020 / PubMed / Full text
Jumping Joints: The Complex Relationship Between Osteoarthritis and Jumping Mechanography. / 02.2020 / PubMed / Full text
Hospitalization Risk among Older Adults with Chronic Kidney Disease. / 2019 / PubMed / Full text
Longitudinal association of carotid endothelial shear stress with renal function decline in aging adults with normal renal function: A population-based cohort study. / 14.02.2019 / PubMed / Full text
Albumin-to-creatinine ratio as a predictor of all-cause mortality and hospitalization of congestive heart failure in Chinese elder hypertensive patients with high cardiovascular risks. / 2018 / PubMed / Full text

AVP

Plasma oxytocin and vasopressin levels in young and older men and women: Functional relationships with attachment and cognition. / 12.2019 / PubMed / Full text
Pathophysiological Mechanisms of Nocturia and Nocturnal Polyuria: The Contribution of Cellular Function, the Urinary Bladder Urothelium, and Circadian Rhythm. / 11.2019 / PubMed / Full text
Neuropeptide changes in the suprachiasmatic nucleus are associated with the development of hypertension. / 08.2019 / PubMed / Full text
The effects of aging on biosynthetic processes in the rat hypothalamic osmoregulatory neuroendocrine system. / 05.2018 / PubMed / Full text
Copeptin and insulin resistance: effect modification by age and 11 β-HSD2 activity in a population-based study. / 07.2018 / PubMed / Full text

BRD4

Inhibition of BRD4 triggers cellular senescence through suppressing aurora kinases in oesophageal cancer cells. / 20.09.2020 / PubMed / Full text
BRD4 contributes to LPS-induced macrophage senescence and promotes progression of atherosclerosis-associated lipid uptake. / 11.05.2020 / PubMed / Full text
BET Proteins Are Required for Transcriptional Activation of the Senescent Islet Cell Secretome in Type 1 Diabetes. / 26.09.2019 / PubMed / Full text
Interference with the bromodomain epigenome readers drives p21 expression and tumor senescence. / 01.10.2019 / PubMed / Full text
Neuroprotective effects of targeting BET proteins for degradation with dBET1 in aged mice subjected to ischemic stroke. / 07.2019 / PubMed / Full text

C5

The C5-75 Program: Meeting the Need for Efficient, Pragmatic Frailty Screening and Management in Primary Care. / 23.06.2020 / PubMed / Full text
Can a relatively large spinal cord for the dural sac influence severity of paralysis in elderly patients with cervical spinal cord injury caused by minor trauma? / 26.06.2020 / PubMed / Full text
Age and Sex-Associated Changes of Complement Activity and Complement Levels in a Healthy Caucasian Population. / 2018 / PubMed / Full text
Longevity of adenovirus vector immunity in mice and its implications for vaccine efficacy. / 29.10.2018 / PubMed / Full text
Generating Rasch-based activity of daily living measures from the Spinal Cord Injury Longitudinal Aging Study. / 01.2018 / PubMed / Full text

C7

The Vertebral Artery Convergence to the Cervical Spine in Elders. / 30.09.2019 / PubMed / Full text
Age-related Changes in Cervical Sagittal Alignment: A Radiographic Analysis. / 01.10.2019 / PubMed / Full text
Early Intravenous Infusion of Mesenchymal Stromal Cells Exerts a Tissue Source Age-Dependent Beneficial Effect on Neurovascular Integrity and Neurobehavioral Recovery After Traumatic Cervical Spinal Cord Injury. / 07.2019 / PubMed / Full text
Age and Sex-Associated Changes of Complement Activity and Complement Levels in a Healthy Caucasian Population. / 2018 / PubMed / Full text
Twenty-year Longitudinal Follow-up MRI Study of Asymptomatic Volunteers: The Impact of Cervical Alignment on Disk Degeneration. / 12.2018 / PubMed / Full text

CCL4

Microglial translational profiling reveals a convergent APOE pathway from aging, amyloid, and tau. / 03.09.2018 / PubMed / Full text
Time-Dependent Changes in Local and Serum Levels of Inflammatory Cytokines as Markers for Incised Wound Aging of Skeletal Muscles. / 05.2018 / PubMed / Full text
Human Body Composition and Immunity: Visceral Adipose Tissue Produces IL-15 and Muscle Strength Inversely Correlates with NK Cell Function in Elderly Humans. / 2018 / PubMed / Full text
Age-related pro-inflammatory and pro-angiogenic changes in human aqueous humor. / 2018 / PubMed / Full text
Age-related decline of the acute local inflammation response: a mitigating role for the adenosine A receptor. / 18.10.2017 / PubMed / Full text

CCR7

Are skin senescence and immunosenescence linked within individuals? / 08.2019 / PubMed / Full text
CCL21/CCR7 axis regulating juvenile cartilage repair can enhance cartilage healing in adults. / 26.03.2019 / PubMed / Full text
Low IL-2 Expressing T Cells in Thalassemia Major Patients: Is It Immune Aging. / 10.2018 / PubMed / Full text
Abnormalities of age-related T cell senescence in Parkinson's disease. / 28.05.2018 / PubMed / Full text
Effects of lifelong training on senescence and mobilization of T lymphocytes in response to acute exercise. / 2018 / PubMed

CD163

Complement Inhibition Attenuates Early Erythrolysis in the Hematoma and Brain Injury in Aged Rats. / 07.2019 / PubMed / Full text
Increased monocyte activation with age among HIV-infected long term non-progressor children: implications for early treatment initiation. / 09.2019 / PubMed / Full text
Age Influences Microglial Activation After Cuprizone-Induced Demyelination. / 2018 / PubMed / Full text
Age-related M1/M2 phenotype changes in circulating monocytes from healthy/unhealthy individuals. / 08.06.2018 / PubMed / Full text
Distinct effect of age, sex, and CMV seropositivity on dendritic cells and monocytes in human blood. / 01.2018 / PubMed / Full text

CD69

CD8 HLADR Regulatory T Cells Change With Aging: They Increase in Number, but Lose Checkpoint Inhibitory Molecules and Suppressive Function. / 2018 / PubMed / Full text
Differential Impact of Obesity on CD69 Expression in Individuals with Bipolar Disorder and Healthy Controls. / 05.2018 / PubMed / Full text
An immunological age index in bipolar disorder: A confirmatory factor analysis of putative immunosenescence markers and associations with clinical characteristics. / 12.2018 / PubMed / Full text
Differences Between Pediatric and Adult T Cell Responses to [i]In Vitro[/i] Staphylococcal Enterotoxin B Stimulation. / 2018 / PubMed / Full text
Associations between immunological function and memory recall in healthy adults. / 12.2017 / PubMed / Full text

CD80

The aging common marmoset's immune system: From junior to senior. / 06.2020 / PubMed / Full text
[i]Akkermansia muciniphila[/i] ameliorates the age-related decline in colonic mucus thickness and attenuates immune activation in accelerated aging [i]Ercc1[/i] mice. / 2019 / PubMed / Full text
The Regulatory Status Adopted by Lymph Node Dendritic Cells and T Cells During Healthy Aging Is Maintained During Cancer and May Contribute to Reduced Responses to Immunotherapy. / 2018 / PubMed / Full text
Age-related M1/M2 phenotype changes in circulating monocytes from healthy/unhealthy individuals. / 08.06.2018 / PubMed / Full text
Elderly dendritic cells respond to LPS/IFN-γ and CD40L stimulation despite incomplete maturation. / 2018 / PubMed / Full text

CD86

Iso-α-acids, Hop-Derived Bitter Components of Beer, Attenuate Age-Related Inflammation and Cognitive Decline. / 2019 / PubMed / Full text
Age-associated antigen-presenting cell alterations promote dry-eye inducing Th1 cells. / 07.2019 / PubMed / Full text
One-Year Consumption of a Mediterranean-Like Dietary Pattern With Vitamin D3 Supplements Induced Small Scale but Extensive Changes of Immune Cell Phenotype, Co-receptor Expression and Innate Immune Responses in Healthy Elderly Subjects: Results From the United Kingdom Arm of the NU-AGE Trial. / 2018 / PubMed / Full text
C-Reactive Protein Impairs Dendritic Cell Development, Maturation, and Function: Implications for Peripheral Tolerance. / 2018 / PubMed / Full text
Immunoglobulin therapy ameliorates the phenotype and increases lifespan in the severely affected dystrophin-utrophin double knockout mice. / 12.2017 / PubMed / Full text

CDA

Cumulative Dis/Advantage and Health Pattern in Late Life: A Comparison between Genders and Welfare State Regimes. / 2019 / PubMed / Full text
Does numerical similarity alter age-related distractibility in working memory? / 2019 / PubMed / Full text
Can working memory capacity be expanded by boosting working memory updating efficiency in older adults? / 12.2018 / PubMed / Full text
Negative Affect Influences Electrophysiological Markers of Visual Working Memory in Mildly Stressed Older Adults. / 2018 / PubMed / Full text
EEG correlates of visual short-term memory in older age vary with adult lifespan cognitive development. / 02.2018 / PubMed / Full text

CLU

Expression of Clusterin suppresses Cr(VI)-induced premature senescence through activation of PI3K/AKT pathway. / 15.11.2019 / PubMed / Full text
Informative combination of CLU rs11136000, serum HDL levels, diabetes, and age as a new piece of puzzle-picture of predictive medicine for cognitive disorders. / 02.2019 / PubMed / Full text
Integrative transcriptome analyses of the aging brain implicate altered splicing in Alzheimer's disease susceptibility. / 11.2018 / PubMed / Full text
DNA methylation analysis on purified neurons and glia dissects age and Alzheimer's disease-specific changes in the human cortex. / 25.07.2018 / PubMed / Full text
Recent studies on cellular and molecular mechanisms in Alzheimer's disease: focus on epigenetic factors and histone deacetylase. / 28.03.2018 / PubMed / Full text

CSF1R

CSF1R inhibitor PLX5622 and environmental enrichment additively improve metabolic outcomes in middle-aged female mice. / 02.02.2020 / PubMed / Full text
Modulation of Microglia by Voluntary Exercise or CSF1R Inhibition Prevents Age-Related Loss of Functional Motor Units. / 05.11.2019 / PubMed / Full text
Forced turnover of aged microglia induces an intermediate phenotype but does not rebalance CNS environmental cues driving priming to immune challenge. / 26.11.2018 / PubMed / Full text
Replacement of microglia in the aged brain reverses cognitive, synaptic, and neuronal deficits in mice. / 12.2018 / PubMed / Full text
Mendelian adult-onset leukodystrophy genes in Alzheimer's disease: critical influence of CSF1R and NOTCH3. / 06.2018 / PubMed / Full text

CXCL9

CXCL9 and CXCL10 display an age-dependent profile in Chagas patients: a cohort study of aging in Bambui, Brazil. / 11.05.2020 / PubMed / Full text
Inflammatory markers and occurrence of falls: Bambuí Cohort Study of Aging. / 01.04.2019 / PubMed / Full text
Age-related pro-inflammatory and pro-angiogenic changes in human aqueous humor. / 2018 / PubMed / Full text
Immune senescence and biomarkers profile of Bambuí aged population-based cohort. / 03.2018 / PubMed / Full text
Predictive value of multiple cytokines and chemokines for mortality in an admixed population: 15-year follow-up of the Bambui-Epigen (Brazil) cohort study of aging. / 11.2017 / PubMed / Full text

CYP11A1

Prepubertal exposure to perfluorononanoic acid interferes with spermatogenesis and steroidogenesis in male mice. / 15.04.2019 / PubMed / Full text
Morphological rearrangement of the cortical region, in aging ovaries. / 07.2019 / PubMed / Full text
Peroxiredoxin 2 deficiency accelerates age-related ovarian failure through the reactive oxygen species-mediated JNK pathway in mice. / 01.08.2018 / PubMed / Full text
Systemic analysis of gene expression profiles in porcine granulosa cells during aging. / 14.11.2017 / PubMed / Full text
Combined toxicity of endosulfan and phenanthrene mixtures and induced molecular changes in adult Zebrafish (Danio rerio). / 03.2018 / PubMed / Full text

DCN

Decorin inhibits the insulin-like growth factor I signaling in bone marrow mesenchymal stem cells of aged humans. / 26.11.2020 / PubMed / Full text
The beneficial effects of 15 units of high-intensity circuit training in women is modified by age, baseline insulin resistance and physical capacity. / 06.2019 / PubMed / Full text
MicroRNA-143-5p targeting eEF2 gene mediates intervertebral disc degeneration through the AMPK signaling pathway. / 15.04.2019 / PubMed / Full text
Does Age Interfere With Gadolinium Toxicity and Presence in Brain and Bone Tissues?: A Comparative Gadoterate Versus Gadodiamide Study in Juvenile and Adult Rats. / 02.2019 / PubMed / Full text
Extracellular proteoglycan decorin maintains human hair follicle stem cells. / 12.2018 / PubMed / Full text

DNMT1

DNA Methyltransferase 1 (DNMT1) Function Is Implicated in the Age-Related Loss of Cortical Interneurons. / 2020 / PubMed / Full text
Age-related Changes in the Global DNA Methylation Profile of Oligodendrocyte Progenitor Cells Derived from Rat Spinal Cords. / 02.2019 / PubMed / Full text
Epigallocatechin-3-gallate and BIX-01294 have different impact on epigenetics and senescence modulation in acute and chronic myeloid leukemia cells. / 05.11.2018 / PubMed / Full text
Resveratrol promotes oxidative stress to drive DLC1 mediated cellular senescence in cancer cells. / 15.09.2018 / PubMed / Full text
Ultraviolet A irradiation induces senescence in human dermal fibroblasts by down-regulating DNMT1 via ZEB1. / 16.02.2018 / PubMed / Full text

ECD

Outcome of Descemet Membrane Endothelial Keratoplasty Using Corneas from Donors ≥80 Years of Age. / 03.2020 / PubMed / Full text
The occurrence and dynamics of polychlorinated hydrocarbons in roe deer ([i]Capreolus capreolus[/i]) in South-western Slovakia. / 2019 / PubMed / Full text
Corneal thickness, endothelial cell density, and morphological and morphometric features of corneal endothelial cells in goats. / 10.2018 / PubMed / Full text
Endothelial cell density and characterization of corneal endothelial cells in the Tawny Owl (Strix aluco) using specular microscopy. / 03.2019 / PubMed / Full text
An autopsy case report: Differences in radiological images correlate with histology in Erdheim-Chester disease. / 06.2018 / PubMed / Full text

EGR1

Glucocorticoids delay RAF-induced senescence promoted by EGR1. / 22.08.2019 / PubMed / Full text
EGR1 promotes the cartilage degeneration and hypertrophy by activating the Krüppel-like factor 5 and β-catenin signaling. / 01.09.2019 / PubMed / Full text
Identification of key genes and transcription factors in aging mesenchymal stem cells by DNA microarray data. / 15.04.2019 / PubMed / Full text
Hypoxia-inducible transcription factors, HIF1A and HIF2A, increase in aging mucosal tissues. / 07.2018 / PubMed / Full text
The p16/miR-217/EGR1 pathway modulates age-related tenogenic differentiation in tendon stem/progenitor cells. / 01.11.2017 / PubMed / Full text

EPO

Regulation of muscle and metabolic physiology by hypothalamic erythropoietin independently of its peripheral action. / 02.2020 / PubMed / Full text
Red Blood Cell Lifespan Shortening in Patients with Early-Stage Chronic Kidney Disease. / 2019 / PubMed / Full text
Age-Dependent Systemic Effects of a Systemic Intermittent Hypoxic Therapy [i]In Vivo[/i]. / 09.2019 / PubMed / Full text
Erythropoietin does not improve fracture healing in aged mice. / 15.07.2019 / PubMed / Full text
Dose-response relationship of intermittent normobaric hypoxia to stimulate erythropoietin in the context of health promotion in young and old people. / 05.2019 / PubMed / Full text

F5

Methylation signatures in peripheral blood are associated with marked age acceleration and disease progression in patients with primary sclerosing cholangitis. / 02.2020 / PubMed / Full text
Fermentation of Blackberry with [i]L. plantarum[/i] JBMI F5 Enhance the Protection Effect on UVB-Mediated Photoaging in Human Foreskin Fibroblast and Hairless Mice through Regulation of MAPK/NF-κB Signaling. / 11.10.2019 / PubMed / Full text
Proof of concept study of age-dependent DNA methylation markers across different tissues by massive parallel sequencing. / 09.2018 / PubMed / Full text
Multigenerational effects of 4-methylbenzylidene camphor (4-MBC) on the survival, development and reproduction of the marine copepod Tigriopus japonicus. / 01.2018 / PubMed / Full text
Chronological age prediction based on DNA methylation: Massive parallel sequencing and random forest regression. / 11.2017 / PubMed / Full text

FGFR1

Alignment of Alzheimer's disease amyloid β-peptide and klotho. / 11-12.2020 / PubMed / Full text
Satellite cell-specific ablation of Cdon impairs integrin activation, FGF signalling, and muscle regeneration. / 08.2020 / PubMed / Full text
Systemic administration of a fibroblast growth factor receptor 1 agonist rescues the cognitive deficit in aged socially isolated rats. / 06.2019 / PubMed / Full text
Impact of aging and caloric restriction on fibroblast growth factor 21 signaling in rat white adipose tissue. / 04.2019 / PubMed / Full text
Activity-dependent neuronal Klotho enhances astrocytic aerobic glycolysis. / 08.2019 / PubMed / Full text

FSHR

FSHR ablation induces depression-like behaviors. / 08.2020 / PubMed / Full text
Direct actions of gonadotropins beyond the reproductive system and their role in human aging and neoplasia [Bezpośrednie działanie gonadotropin poza układem rozrodczym i ich rola w starzeniu się i nowotworzeniu u człowieka]. / 2019 / PubMed / Full text
Follicle-stimulating hormone promotes renal tubulointerstitial fibrosis in aging women via the AKT/GSK-3β/β-catenin pathway. / 10.2019 / PubMed / Full text
Growth hormone during in vitro fertilization in older women modulates the density of receptors in granulosa cells, with improved pregnancy outcomes. / 12.2018 / PubMed / Full text
Diurnal rhythm of follicle-stimulating hormone is associated with nonalcoholic fatty liver disease in a Chinese elderly population. / 03.2018 / PubMed / Full text

FUS

HPV shapes tumor transcriptome by globally modifying the pool of RNA binding protein-binding motif. / 29.04.2019 / PubMed / Full text
Memory Decline and Its Reversal in Aging and Neurodegeneration Involve miR-183/96/182 Biogenesis. / 05.2019 / PubMed / Full text
[Development of imaging-based diagnostic procedures for brain protein aging using a mouse model of tauopathy]. / 2018 / PubMed / Full text
Riluzole does not improve lifespan or motor function in three ALS mouse models. / 08.2018 / PubMed / Full text
Investigation of the Safety of Focused Ultrasound-Induced Blood-Brain Barrier Opening in a Natural Canine Model of Aging. / 2017 / PubMed / Full text

GCA

Familial aggregation of longevity in giant cell arteritis and polymyalgia rheumatica. / 12.2020 / PubMed / Full text
Interaction between Alcohol Consumption and Apolipoprotein E (ApoE) Genotype with Cognition in Middle-Aged Men. / 14.07.2020 / PubMed / Full text
Influence of young adult cognitive ability and additional education on later-life cognition. / 05.02.2019 / PubMed / Full text
Altered effective connectivity anchored in the posterior cingulate cortex and the medial prefrontal cortex in cognitively intact elderly APOE ε4 carriers: a preliminary study. / 02.2019 / PubMed / Full text
Global Cerebral Atrophy Detected by Routine Imaging: Relationship with Age, Hippocampal Atrophy, and White Matter Hyperintensities. / 05.2018 / PubMed / Full text

GHR

Tissue-Specific GHR Knockout Mice: An Updated Review. / 2020 / PubMed / Full text
The mir-465 family is upregulated with age and attenuates growth hormone signaling in mouse liver. / 04.2019 / PubMed / Full text
Growth hormone during in vitro fertilization in older women modulates the density of receptors in granulosa cells, with improved pregnancy outcomes. / 12.2018 / PubMed / Full text
Effects of rapamycin on growth hormone receptor knockout mice. / 13.02.2018 / PubMed / Full text
Disruption of the GH receptor gene in adult mice and in insulin sensitive tissues. / 02.2018 / PubMed / Full text

GHRH

Physiological and metabolic features of mice with CRISPR/Cas9-mediated loss-of-function in growth hormone-releasing hormone. / 18.05.2020 / PubMed / Full text
Transcriptomic and metabolomic profiling of long-lived growth hormone releasing hormone knock-out mice: evidence for altered mitochondrial function and amino acid metabolism. / 23.02.2020 / PubMed / Full text
Roles of peptides and steroids in sleep disorders. / 09.2006 / PubMed / Full text
Growth Hormone Deficiency: Health and Longevity. / 01.04.2019 / PubMed / Full text
Aromatized Estrogens Amplify Nocturnal Growth Hormone Secretion in Testosterone-Replaced Older Hypogonadal Men. / 01.12.2018 / PubMed / Full text

GIP

Absence of GIP secretion alleviates age-related obesity and insulin resistance. / 04.2020 / PubMed / Full text
Inhibition of GIP signaling extends lifespan without caloric restriction. / 11.06.2019 / PubMed / Full text
Transcriptional factor Pdx1 is involved in age-related GIP hypersecretion in mice. / 01.08.2018 / PubMed / Full text
Older Subjects With β-Cell Dysfunction Have an Accentuated Incretin Release. / 01.07.2018 / PubMed / Full text
Effect of Age on Blood Glucose and Plasma Insulin, Glucagon, Ghrelin, CCK, GIP, and GLP-1 Responses to Whey Protein Ingestion. / 21.12.2017 / PubMed / Full text

GRN

Stressful development: Integrating endoderm development, stress, and longevity. / 08.12.2020 / PubMed / Full text
A Scoping Review of the Evidence About the Nurses Improving Care for Healthsystem Elders (NICHE) Program. / 04.11.2019 / PubMed / Full text
Methods to Investigate the Molecular Basis of Progranulin Actions on Brain and Behavior In Vivo Using Knockout Mice. / 2018 / PubMed / Full text
Combined Pathologies in FTLD-TDP Types A and C. / 01.05.2018 / PubMed / Full text
A potent tilapia secreted granulin peptide enhances the survival of transgenic zebrafish infected by Vibrio vulnificus via modulation of innate immunity. / 04.2018 / PubMed / Full text

HDAC6

Inhibition of HDAC6 Attenuates Diabetes-Induced Retinal Redox Imbalance and Microangiopathy. / 09.07.2020 / PubMed / Full text
Cellular senescence is associated with reorganization of the microtubule cytoskeleton. / 03.2019 / PubMed / Full text
2,4‑Di‑tert‑butylphenol, a potential HDAC6 inhibitor, induces senescence and mitotic catastrophe in human gastric adenocarcinoma AGS cells. / 05.2018 / PubMed / Full text
HDAC6 Suppresses Age-Dependent Ectopic Fat Accumulation by Maintaining the Proteostasis of PLIN2 in Drosophila. / 09.10.2017 / PubMed / Full text
The Deacetylase HDAC6 Mediates Endogenous Neuritic Tau Pathology. / 29.08.2017 / PubMed / Full text

HTT

Biological Aging and the Cellular Pathogenesis of Huntington's Disease. / 2020 / PubMed / Full text
Striatal Mutant Huntingtin Protein Levels Decline with Age in Homozygous Huntington's Disease Knock-In Mouse Models. / 2018 / PubMed / Full text
Early Neurodegeneration in R6/2 Mice Carrying the Huntington's Disease Mutation with a Super-Expanded CAG Repeat, Despite Normal Lifespan. / 2018 / PubMed / Full text
Striatal neurons directly converted from Huntington's disease patient fibroblasts recapitulate age-associated disease phenotypes. / 03.2018 / PubMed / Full text
Cell-to-cell Transmission of Polyglutamine Aggregates in [i]C. elegans[/i]. / 12.2017 / PubMed / Full text

IGF1R

Comparison of mitochondrial transplantation by using a stamp-type multineedle injector and platelet-rich plasma therapy for hair aging in naturally aging mice. / 10.2020 / PubMed / Full text
In mice transgenic for IGF1 under keratin-14 promoter, lifespan is decreased and the rates of aging and thymus involution are accelerated. / 13.04.2019 / PubMed / Full text
Insulin/IGF-1 signaling and aging. / 09.2016 / PubMed
Effect of young exosomes injected in aged mice. / 2018 / PubMed / Full text
The genetic component of human longevity: New insights from the analysis of pathway-based SNP-SNP interactions. / 06.2018 / PubMed / Full text

KEAP1

NRF2 pathway activation by KEAP1 inhibition attenuates the manifestation of aging phenotypes in salivary glands. / 09.2020 / PubMed / Full text
Adaptation of the master antioxidant response connects metabolism, lifespan and feather development pathways in birds. / 18.05.2020 / PubMed / Full text
Inflammatory and Senescent Phenotype of Pancreatic Stellate Cells Induced by Sqstm1 Downregulation Facilitates Pancreatic Cancer Progression. / 2019 / PubMed / Full text
Systemic overexpression of SQSTM1/p62 accelerates disease onset in a SOD1 -expressing ALS mouse model. / 29.05.2018 / PubMed / Full text
Sulfur amino acid restriction-induced changes in redox-sensitive proteins are associated with slow protein synthesis rates. / 04.2018 / PubMed / Full text

LMNB1

SIRT1 - a new mammalian substrate of nuclear autophagy. / 08.12.2020 / PubMed / Full text
Cellular senescence as a response to multiwalled carbon nanotube (MWCNT) exposure in human mesothelial cells. / 03.12.2020 / PubMed / Full text
Inflammatory Drivers of Cardiovascular Disease: Molecular Characterization of Senescent Coronary Vascular Smooth Muscle Cells. / 2020 / PubMed / Full text
Neuronal [i]Lamin[/i] regulates motor circuit integrity and controls motor function and lifespan. / 17.08.2018 / PubMed / Full text
KMT1 family methyltransferases regulate heterochromatin-nuclear periphery tethering via histone and non-histone protein methylation. / 05.2019 / PubMed / Full text

LPP

Effects of lifelong intake of lemon polyphenols on aging and intestinal microbiome in the senescence-accelerated mouse prone 1 (SAMP1). / 06.03.2019 / PubMed / Full text
Age differences in the neural correlates underlying control of emotional memory: An event-related potential study. / 15.10.2018 / PubMed / Full text
The Influence of Emotional Material on Encoding and Retrieving Intentions: An ERP Study in Younger and Older Adults. / 2018 / PubMed / Full text
Convergence of BOLD and ERP measures of neural reactivity to emotional faces in children and adolescents with and without anxiety disorders. / 04.2018 / PubMed / Full text
Urethral function and histopathology in aged female rats as a stress urinary incontinence model. / 04.2019 / PubMed / Full text

MAP2

Protective effects of ischemic preconditioning against neuronal apoptosis and dendritic injury in the hippocampus are age-dependent. / 11.2020 / PubMed / Full text
SerThr-PhosphoProteome of Brain from Aged PINK1-KO+A53T-SNCA Mice Reveals pT1928-MAP1B and pS3781-ANK2 Deficits, as Hub between Autophagy and Synapse Changes. / 04.07.2019 / PubMed / Full text
DNA methylation analysis on purified neurons and glia dissects age and Alzheimer's disease-specific changes in the human cortex. / 25.07.2018 / PubMed / Full text
Systemic overexpression of SQSTM1/p62 accelerates disease onset in a SOD1 -expressing ALS mouse model. / 29.05.2018 / PubMed / Full text
Long-term treadmill exercise improves memory impairment through restoration of decreased synaptic adhesion molecule 1/2/3 induced by transient cerebral ischemia in the aged gerbil hippocampus. / 03.2018 / PubMed / Full text

MECP2

Senescence Phenomena and Metabolic Alteration in Mesenchymal Stromal Cells from a Mouse Model of Rett Syndrome. / 21.05.2019 / PubMed / Full text
A Novel Mecp2 Knock-in Model Displays Similar Behavioral Traits But Distinct Molecular Features Compared to the Mecp2-Null Mouse Implying Precision Medicine for the Treatment of Rett Syndrome. / 07.2019 / PubMed / Full text
Tsix-Mecp2 female mouse model for Rett syndrome reveals that low-level MECP2 expression extends life and improves neuromotor function. / 07.08.2018 / PubMed / Full text
Epilepsy in classic Rett syndrome: Course and characteristics in adult age. / 09.2018 / PubMed / Full text
Loss of MECP2 Leads to Activation of P53 and Neuronal Senescence. / 08.05.2018 / PubMed / Full text

MGMT

Cytotoxic and Senolytic Effects of Methadone in Combination with Temozolomide in Glioblastoma Cells. / 23.09.2020 / PubMed / Full text
Profound, durable and MGMT-independent sensitivity of glioblastoma cells to cyclin-dependent kinase inhibition. / 01.07.2019 / PubMed / Full text
Influence of aging in the modulation of epigenetic biomarkers of carcinogenesis after exposure to air pollution. / 09.2018 / PubMed / Full text
Integrated study on comparative transcriptome and skeletal muscle function in aged rats. / 01.2018 / PubMed / Full text
Proteomics and metabolomics identify molecular mechanisms of aging potentially predisposing for chronic lymphocytic leukemia. / 02.2018 / PubMed / Full text

MIA

Age, cohort, and period effects on metamemory beliefs. / 12.2019 / PubMed / Full text
Memory Age-based Stereotype Threat: Role of Locus of Control and Anxiety. / 01-02.2020 / PubMed / Full text
Role of melanoma inhibitory activity in melanocyte senescence. / 11.2019 / PubMed / Full text
Refining the metamemory in adulthood questionnaire: a 20-item version of change and capacity designed for research and clinical settings. / 07.2020 / PubMed / Full text
Maternal Immune Activation Alters Adult Behavior, Gut Microbiome and Juvenile Brain Oscillations in Ferrets. / 09-10.2018 / PubMed / Full text

MITF

Thymocid , a Standardized Black Cumin ([i]Nigella sativa[/i]) Seed Extract, Modulates Collagen Cross-Linking, Collagenase and Elastase Activities, and Melanogenesis in Murine B16F10 Melanoma Cells. / 19.07.2020 / PubMed / Full text
HuRdling Senescence: HuR Breaks BRAF-Induced Senescence in Melanocytes and Supports Melanoma Growth. / 21.05.2020 / PubMed / Full text
Extracellular acidosis triggers a senescence-like phenotype in human melanoma cells. / 01.2020 / PubMed / Full text
H O promotes the aging process of melanogenesis through modulation of MITF and Nrf2. / 04.2019 / PubMed / Full text
Deregulated MITF sumoylation: A route to melanoma. / 2017 / PubMed / Full text

MMD

Association between a Deficit Accumulation Frailty Index and Mobility Outcomes in Older Adults: Secondary Analysis of the Lifestyle Interventions and Independence for Elders (LIFE) Study. / 22.11.2020 / PubMed / Full text
Impact of Anticholinergic Medication Burden on Mobility and Falls in the Lifestyle Interventions for Elders (LIFE) Study. / 16.09.2020 / PubMed / Full text
Impact and Lessons From the Lifestyle Interventions and Independence for Elders (LIFE) Clinical Trials of Physical Activity to Prevent Mobility Disability. / 04.2020 / PubMed / Full text
Lactobacillus rescues postnatal neurobehavioral and microglial dysfunction in a model of maternal microbiome dysbiosis. / 10.2019 / PubMed / Full text
A Case for Promoting Movement Medicine: Preventing Disability in the LIFE Randomized Controlled Trial. / 04.10.2019 / PubMed / Full text

MTHFR

One-carbon metabolism supplementation improves outcome after stroke in aged male MTHFR-deficient mice. / 12.2019 / PubMed / Full text
One-carbon metabolism gene polymorphisms are associated with cognitive trajectory among African-American adults. / 12.2019 / PubMed / Full text
Dietary Intervention Modifies DNA Methylation Age Assessed by the Epigenetic Clock. / 12.2018 / PubMed / Full text
Early Manifestations of Brain Aging in Mice Due to Low Dietary Folate and Mild MTHFR Deficiency. / 06.2019 / PubMed / Full text
Methylenetetrahydrofolate Reductase Deficiency Deregulates Regional Brain Amyloid-β Protein Precursor Expression and Phosphorylation Levels. / 2018 / PubMed / Full text

NANOG

Restoring extracellular matrix synthesis in senescent stem cells. / 10.2019 / PubMed / Full text
Maternal ageing impairs mitochondrial DNA kinetics during early embryogenesis in mice. / 08.07.2019 / PubMed / Full text
Amnion epithelial cell-derived exosomes induce inflammatory changes in uterine cells. / 11.2018 / PubMed / Full text
NANOG restores the impaired myogenic differentiation potential of skeletal myoblasts after multiple population doublings. / 01.2018 / PubMed / Full text
Some chemotherapeutics-treated colon cancer cells display a specific phenotype being a combination of stem-like and senescent cell features. / 02.01.2018 / PubMed / Full text

P2RY12

Potential caveats of putative microglia-specific markers for assessment of age-related cerebrovascular neuroinflammation. / 01.12.2020 / PubMed / Full text
Microglial changes in the early aging stage in a healthy retina and an experimental glaucoma model. / 2020 / PubMed / Full text
Patterns of Expression of Purinergic Receptor P2RY12, a Putative Marker for Non-Activated Microglia, in Aged and Alzheimer's Disease Brains. / 20.01.2020 / PubMed / Full text
Age Influences Microglial Activation After Cuprizone-Induced Demyelination. / 2018 / PubMed / Full text
Dexamethasone Induces a Specific Form of Ramified Dysfunctional Microglia. / 02.2019 / PubMed / Full text

PER2

NAD Controls Circadian Reprogramming through PER2 Nuclear Translocation to Counter Aging. / 04.06.2020 / PubMed / Full text
The protective effect of cycloastragenol on aging mouse circadian rhythmic disorder induced by d-galactose. / 10.2019 / PubMed / Full text
Investigating circadian clock gene expression in human tendon biopsies from acute exercise and immobilization studies. / 06.2019 / PubMed / Full text
Is the aging human ovary still ticking?: Expression of clock-genes in luteinized granulosa cells of young and older women. / 21.11.2018 / PubMed / Full text
Ontogeny of Circadian Rhythms and Synchrony in the Suprachiasmatic Nucleus. / 07.02.2018 / PubMed / Full text

PIK3CA

Myocyte enhancer factor 2A delays vascular endothelial cell senescence by activating the PI3K/p-Akt/SIRT1 pathway. / 10.06.2019 / PubMed / Full text
Oncogenic mutations in histologically normal endometrium: the new normal? / 10.2019 / PubMed / Full text
A clinical trial of somatic and germline analyses for healthy longevity in a postoperative cancer patient. / 09.2019 / PubMed / Full text
Membrane metallo-endopeptidase mediates cellular senescence induced by oncogenic PIK3CA accompanied with pro-tumorigenic secretome. / 01.08.2019 / PubMed / Full text
Therapeutic and preventive effects of exercise on cardiometabolic parameters in aging and obese rats. / 02.2019 / PubMed / Full text

RIPK3

Metformin mediates cardioprotection against aging-induced ischemic necroptosis. / 02.2020 / PubMed / Full text
A small molecule Nec-1 directly induces amyloid clearance in the brains of aged APP/PS1 mice. / 12.03.2019 / PubMed / Full text
RIP kinases as modulators of inflammation and immunity. / 09.2018 / PubMed / Full text
Necroptosis increases with age and is reduced by dietary restriction. / 08.2018 / PubMed / Full text
RIPK1-RIPK3-MLKL-dependent necrosis promotes the aging of mouse male reproductive system. / 15.08.2017 / PubMed / Full text

ROCK2

Physical exercise increases ROCK activity in the skeletal muscle of middle-aged rats. / 03.2020 / PubMed / Full text
Disruption of both ROCK1 and ROCK2 genes in cardiomyocytes promotes autophagy and reduces cardiac fibrosis during aging. / 06.2019 / PubMed / Full text
Role of age, Rho-kinase 2 expression, and G protein-mediated signaling in the myogenic response in mouse small mesenteric arteries. / 09.2018 / PubMed / Full text
Vascular Smooth Muscle Contractile Function Declines With Age in Skeletal Muscle Feed Arteries. / 2018 / PubMed / Full text
Changes in Cerebral Arteries and Parenchymal Arterioles With Aging: Role of Rho Kinase 2 and Impact of Genetic Background. / 05.2018 / PubMed / Full text

SAG

WRKY42 transcription factor positively regulates leaf senescence through modulating SA and ROS synthesis in Arabidopsis thaliana. / 09.2020 / PubMed / Full text
Neurogenesis in the inner ear: the zebrafish statoacoustic ganglion provides new neurons from a Neurod/Nestin-positive progenitor pool well into adulthood. / 10.04.2020 / PubMed / Full text
Effects of natural dietary supplementation with Macleaya cordata extract containing sanguinarine on growth performance and gut health of early-weaned piglets. / 12.2018 / PubMed / Full text
Genetic redundancy of senescence-associated transcription factors in Arabidopsis. / 12.02.2018 / PubMed / Full text
Proteomic Investigations of Proteases Involved in Cotyledon Senescence: A Model to Explore the Genotypic Variability of Proteolysis Machinery Associated with Nitrogen Remobilization Efficiency during the Leaf Senescence of Oilseed Rape. / 02.11.2017 / PubMed / Full text

SMAD3

Sirtuin 6 deficiency transcriptionally up-regulates TGF-β signaling and induces fibrosis in mice. / 10.01.2020 / PubMed / Full text
Restoring extracellular matrix synthesis in senescent stem cells. / 10.2019 / PubMed / Full text
Chromatin remodeling factor BAZ1A regulates cellular senescence in both cancer and normal cells. / 15.07.2019 / PubMed / Full text
Histopathological and molecular analysis of idiopathic pulmonary fibrosis lungs from patients treated with pirfenidone or nintedanib. / 01.2019 / PubMed / Full text
Beta-Catenin and SMAD3 Are Associated with Skeletal Muscle Aging in the Taurine Transpoeter Knockout Mouse. / 2017 / PubMed / Full text

SNCA

Behavioural and dopaminergic changes in double mutated human A30P*A53T alpha-synuclein transgenic mouse model of Parkinson´s disease. / 22.11.2019 / PubMed / Full text
Reducing INS-IGF1 signaling protects against non-cell autonomous vesicle rupture caused by SNCA spreading. / 05.2020 / PubMed / Full text
SerThr-PhosphoProteome of Brain from Aged PINK1-KO+A53T-SNCA Mice Reveals pT1928-MAP1B and pS3781-ANK2 Deficits, as Hub between Autophagy and Synapse Changes. / 04.07.2019 / PubMed / Full text
Age-dependent accumulation of oligomeric SNCA/α-synuclein from impaired degradation in mutant LRRK2 knockin mouse model of Parkinson disease: role for therapeutic activation of chaperone-mediated autophagy (CMA). / 02.2020 / PubMed / Full text
Caloric restriction rescues yeast cells from alpha-synuclein toxicity through autophagic control of proteostasis. / 07.12.2018 / PubMed / Full text

SON

Absence of axonal sprouting following unilateral lesion in 125-day-old rat supraoptic nucleus may be due to age-dependent decrease in protein levels of ciliary neurotrophic factor receptor alpha. / 01.10.2019 / PubMed / Full text
Neural Mechanisms Involved in the Noxious Physical Stress-Induced Inhibition of Ovarian Estradiol Secretion. / 06.2019 / PubMed / Full text
Aging affects isoproterenol-induced water drinking, astrocyte density, and central neuronal activation in female Brown Norway rats. / 01.08.2018 / PubMed / Full text
The effects of aging on biosynthetic processes in the rat hypothalamic osmoregulatory neuroendocrine system. / 05.2018 / PubMed / Full text
Increased oxytocin-monomeric red fluorescent protein 1 fluorescent intensity with urocortin-like immunoreactivity in the hypothalamo-neurohypophysial system of aged transgenic rats. / 03.2018 / PubMed / Full text

SRF

Changes in snail and SRF expression in the kidneys of diabetic rats during ageing. / 01.2020 / PubMed / Full text
Mechanosensitive transcriptional coactivators MRTF-A and YAP/TAZ regulate nucleus pulposus cell phenotype through cell shape. / 12.2019 / PubMed / Full text
Resource recovery potentials by landfill mining and reclamation in South Korea. / 15.07.2019 / PubMed / Full text
Pre-existing fibroblasts of epicardial origin are the primary source of pathological fibrosis in cardiac ischemia and aging. / 04.2019 / PubMed / Full text
Targeting MRTF/SRF in CAP2-dependent dilated cardiomyopathy delays disease onset. / 21.03.2019 / PubMed / Full text

TAZ

Transcriptional Coactivator TAZ Negatively Regulates Tumor Suppressor p53 Activity and Cellular Senescence. / 09.01.2020 / PubMed / Full text
Downregulation of miR-125b promotes resistance of glioma cells to TRAIL through overexpression of Tafazzin which is a mitochondrial protein. / 05.05.2019 / PubMed / Full text
Dysregulation of the Hippo pathway signaling in aging and cancer. / 05.2019 / PubMed / Full text
Long noncoding RNA Bmncr regulates mesenchymal stem cell fate during skeletal aging. / 03.12.2018 / PubMed / Full text
PGC-1α Controls Skeletal Stem Cell Fate and Bone-Fat Balance in Osteoporosis and Skeletal Aging by Inducing TAZ. / 02.08.2018 / PubMed / Full text

TRPM2

Paraquat as an Environmental Risk Factor in Parkinson's Disease Accelerates Age-Related Degeneration Via Rapid Influx of Extracellular Zn into Nigral Dopaminergic Neurons. / 11.2019 / PubMed / Full text
Pathophysiological Role of TRPM2 in Age-Related Cognitive Impairment in Mice. / 01.06.2019 / PubMed / Full text
The TRPM2 channel nexus from oxidative damage to Alzheimer's pathologies: An emerging novel intervention target for age-related dementia. / 11.2018 / PubMed / Full text
TRPM2 in the Brain: Role in Health and Disease. / 22.07.2018 / PubMed / Full text
mRNA expression of transient receptor potential melastatin (TRPM) channels 2 and 7 in perinatal brain development. / 10.2018 / PubMed / Full text

TTR

Cellular secretion and cytotoxicity of transthyretin mutant proteins underlie late-onset amyloidosis and neurodegeneration. / 04.2020 / PubMed / Full text
Development of transgenic Caenorhabditis elegans expressing human transthyretin as a model for drug screening. / 14.12.2018 / PubMed / Full text
Age-dependent cognitive dysfunction in untreated hereditary transthyretin amyloidosis. / 02.2018 / PubMed / Full text
The delaying effect of alpha-glycerophosphocholine on senescence, transthyretin deposition, and osteoarthritis in senescence-accelerated mouse prone 8 mice. / 04.2018 / PubMed / Full text
Transthyretin deposition promotes progression of osteoarthritis. / 12.2017 / PubMed / Full text

ZMPSTE24

Bone marrow-derived mesenchymal stem cells in three-dimensional co-culture attenuate degeneration of nucleus pulposus cells. / 30.10.2019 / PubMed / Full text
A humanized yeast system to analyze cleavage of prelamin A by ZMPSTE24. / 15.03.2019 / PubMed / Full text
Proteomic Evidence of Biological Aging in a Child with a Compound Heterozygous ZMPSTE24 Mutation. / 03.2019 / PubMed / Full text
Abnormal nuclear morphology is independent of longevity in a zmpste24-deficient fish model of Hutchinson-Gilford progeria syndrome (HGPS). / 07.2018 / PubMed / Full text
Mandibuloacral dysplasia: A premature ageing disease with aspects of physiological ageing. / 03.2018 / PubMed / Full text

ADA

Adenosine Metabolism in the Cerebral Cortex from Several Mice Models during Aging. / 02.10.2020 / PubMed / Full text
Risk factors for diabetic kidney disease in adults with longstanding type 1 diabetes: results from the Canadian Study of Longevity in Diabetes. / 11.2019 / PubMed / Full text
Ideglira is Associated With Improved Short-Term Clinical Outcomes and Cost Savings Compared with Insulin Glargine U100 Plus Insulin Aspart in the U.S. / 09.2018 / PubMed / Full text
Mismatch between ADA and AGS recommendations for glycated hemoglobin targets for older adults. / 04.2018 / PubMed / Full text

AHR

Indoles from the commensal microbiota act via the AHR and IL-10 to tune the cellular composition of the colonic epithelium during aging. / 01.09.2020 / PubMed / Full text
Role of the Aryl Hydrocarbon Receptor in Environmentally Induced Skin Aging and Skin Carcinogenesis. / 28.11.2019 / PubMed / Full text
Loss of Neurogenesis in Aging Hydra. / 05.2019 / PubMed / Full text
Environmental cues received during development shape dendritic cell responses later in life. / 2018 / PubMed / Full text

BPIFB4

New Insights for BPIFB4 in Cardiovascular Therapy. / 28.09.2020 / PubMed / Full text
LAV-BPIFB4 associates with reduced frailty in humans and its transfer prevents frailty progression in old mice. / 28.08.2019 / PubMed / Full text
Longevity-Associated Variant of BPIFB4 Mitigates Monocyte-Mediated Acquired Immune Response. / 13.11.2019 / PubMed / Full text
A Model of Evolutionary Selection: The Cardiovascular Protective Function of the Longevity Associated Variant of BPIFB4. / 19.10.2018 / PubMed / Full text

C6

Evolution of the Aroma of Treixadura Wines during Bottle Aging. / 08.10.2020 / PubMed / Full text
D-galactose induces senescence of glioblastoma cells through YAP-CDK6 pathway. / 29.09.2020 / PubMed / Full text
Alcohol Extracts From [i]Ganoderma lucidum[/i] Delay the Progress of Alzheimer's Disease by Regulating DNA Methylation in Rodents. / 2019 / PubMed / Full text
Age and Sex-Associated Changes of Complement Activity and Complement Levels in a Healthy Caucasian Population. / 2018 / PubMed / Full text

CD33

Maximum reproductive lifespan correlates with CD33rSIGLEC gene number: Implications for NADPH oxidase-derived reactive oxygen species in aging. / 02.2020 / PubMed / Full text
New genetic players in late-onset Alzheimer's disease: Findings of genome-wide association studies. / 08.2018 / PubMed / Full text
Chromogenic Multiplex Immunohistochemistry Reveals Modulation of the Immune Microenvironment Associated with Survival in Elderly Patients with Lung Adenocarcinoma. / 13.09.2018 / PubMed / Full text
Recent studies on cellular and molecular mechanisms in Alzheimer's disease: focus on epigenetic factors and histone deacetylase. / 28.03.2018 / PubMed / Full text

CRH

Roles of peptides and steroids in sleep disorders. / 09.2006 / PubMed / Full text
Novel molecular mechanisms for the adaptogenic effects of herbal extracts on isolated brain cells using systems biology. / 15.11.2018 / PubMed / Full text
Caenorhabditis elegans respond to high-glucose diets through a network of stress-responsive transcription factors. / 2018 / PubMed / Full text
Genome-wide association study and annotating candidate gene networks affecting age at first calving in Nellore cattle. / 12.2017 / PubMed / Full text

CXCL8

Cerebrovascular Senescence Is Associated With Tau Pathology in Alzheimer's Disease. / 2020 / PubMed / Full text
Age-related pro-inflammatory and pro-angiogenic changes in human aqueous humor. / 2018 / PubMed / Full text
Immune senescence and biomarkers profile of Bambuí aged population-based cohort. / 03.2018 / PubMed / Full text
Predictive value of multiple cytokines and chemokines for mortality in an admixed population: 15-year follow-up of the Bambui-Epigen (Brazil) cohort study of aging. / 11.2017 / PubMed / Full text

CXCR3

Senescent hepatocytes enhance natural killer cell activity via the CXCL-10/CXCR3 axis. / 11.2019 / PubMed / Full text
Age-associated antigen-presenting cell alterations promote dry-eye inducing Th1 cells. / 07.2019 / PubMed / Full text
CXCR3 CD8 T cells with naïve phenotype and high capacity for IFN-γ production are generated during homeostatic T-cell proliferation. / 10.2018 / PubMed / Full text
The parasite-derived rOv-ASP-1 is an effective antigen-sparing CD4 T cell-dependent adjuvant for the trivalent inactivated influenza vaccine, and functions in the absence of MyD88 pathway. / 14.06.2018 / PubMed / Full text

CYP2C19

Physiologically Based Pharmacokinetic Approach Can Successfully Predict Pharmacokinetics of Citalopram in Different Patient Populations. / 04.2020 / PubMed / Full text
Longitudinal exposure of English primary care patients to pharmacogenomic drugs: An analysis to inform design of pre-emptive pharmacogenomic testing. / 12.2019 / PubMed / Full text
The safety, tolerability and pharmacokinetics of BI 409306, a novel and potent PDE9 inhibitor: Overview of three Phase I randomised trials in healthy volunteers. / 05.2018 / PubMed / Full text
Pediatric Cytochrome P450 Activity Alterations in Nonalcoholic Steatohepatitis. / 12.2017 / PubMed / Full text

CYP2E1

DNA methylation and histone acetylation changes to cytochrome P450 2E1 regulation in normal aging and impact on rates of drug metabolism in the liver. / 06.2020 / PubMed / Full text
2, 3, 4', 5-tetrahydroxystilbene-2-0-β-d Glycoside Attenuates Age- and Diet-Associated Non-Alcoholic Steatohepatitis and Atherosclerosis in LDL Receptor Knockout Mice and Its Possible Mechanisms. / 01.04.2019 / PubMed / Full text
Neuroprotective Effect of Dioscin on the Aging Brain. / 30.03.2019 / PubMed / Full text
Cytochrome P450-2E1 is involved in aging-related kidney damage in mice through increased nitroxidative stress. / 11.2017 / PubMed / Full text

DCC

X Chromosome Domain Architecture Regulates Caenorhabditis elegans Lifespan but Not Dosage Compensation. / 21.10.2019 / PubMed / Full text
Dynamic functional connectivity analysis of functional MRI based on copula time-varying correlation. / 15.07.2019 / PubMed / Full text
Comprehensive outpatient rehabilitation increases the ability of people over 60 to live independently. / 20.12.2018 / PubMed / Full text
Mesocorticolimbic Connectivity and Volumetric Alterations in [i]DCC[/i] Mutation Carriers. / 16.05.2018 / PubMed / Full text

EFS

The aging bladder phenotype is not the direct consequence of bladder aging. / 11.2019 / PubMed / Full text
Autonomic dysregulation at multiple sites is implicated in age-associated underactive bladder in female mice. / 06.2019 / PubMed / Full text
Does the empty follicle syndrome occur in cases of low number of maturing follicles in assisted reproduction? / 04.2019 / PubMed / Full text
Changes in the interstitial cells of Cajal and neuronal nitric oxide synthase positive neuronal cells with aging in the esophagus of F344 rats. / 2017 / PubMed / Full text

ERAS

Enhanced Recovery After Surgery: Are the Principles Applicable to Adult and Geriatric Acute Care and Trauma Surgery? / 03.2019 / PubMed / Full text
Prospective application of an implementation framework to improve postoperative nutrition care processes: Evaluation of a mixed methods implementation study. / 09.2018 / PubMed / Full text
Enhanced Recovery After Surgery (ERAS) - The Evidence in Geriatric Emergency Surgery: A Systematic Review. / Sept-10.2017 / PubMed / Full text
Multimodal Rehabilitation in Geriatric Emergency Surgery. / Sept-10.2017 / PubMed / Full text

FGA

Goal Pursuit, Goal Adjustment, and Pain in Middle-Aged Adults Aging With Physical Disability. / 12.2019 / PubMed / Full text
Tenacious Goal Pursuit, Flexible Goal Adjustment, and Life Satisfaction Among Chinese Older Adult Couples. / 01.2020 / PubMed / Full text
Association of tenacious goal pursuit and flexible goal adjustment with out-of-home mobility among community-dwelling older people. / 09.2019 / PubMed / Full text
Assimilative and accommodative coping in older adults with and without sensory impairment: four-year change and prospective relations with affective well-being. / 09.2019 / PubMed / Full text

FGF19

Bile acid receptor agonists in primary biliary cholangitis: Regulation of the cholangiocyte secretome and downstream T cell differentiation. / 05.2019 / PubMed / Full text
Kotho and aging. / 09.2016 / PubMed
The Klotho proteins in health and disease. / 01.2019 / PubMed / Full text
Peroxisomal Acyl-CoA Oxidase Type 1: Anti-Inflammatory and Anti-Aging Properties with a Special Emphasis on Studies with LPS and Argan Oil as a Model Transposable to Aging. / 2018 / PubMed / Full text

FGF2

The influence of fibroblast growth factor 2 on the senescence of human adipose-derived mesenchymal stem cells during long-term culture. / 04.2020 / PubMed / Full text
Adipose-Derived Stem/Stromal Cells Recapitulate Aging Biomarkers and Show Reduced Stem Cell Plasticity Affecting Their Adipogenic Differentiation Capacity. / 08.2019 / PubMed / Full text
Evaluation of human mesenchymal stem cell senescence, differentiation and secretion behavior cultured on polycarbonate cell culture inserts. / 2018 / PubMed / Full text
Young bone marrow Sca-1 cells protect aged retina from ischaemia-reperfusion injury through activation of FGF2. / 12.2018 / PubMed / Full text

FGR

Aurora kinase mRNA expression is reduced with increasing gestational age and in severe early onset fetal growth restriction. / 06.2020 / PubMed / Full text
Premature Vascular Aging in Guinea Pigs Affected by Fetal Growth Restriction. / 15.07.2019 / PubMed / Full text
Premature placental aging in term small-for-gestational-age and growth-restricted fetuses. / 05.2019 / PubMed / Full text
The effect of fertility treatment on adverse perinatal outcomes in women aged at least 40 years. / 01.2018 / PubMed / Full text

FOXM1

Sirtuin 6 deficiency induces endothelial cell senescence via downregulation of forkhead box M1 expression. / 10.11.2020 / PubMed / Full text
Upregulation of FOXM1 leads to diminished drug sensitivity in myeloma. / 21.11.2018 / PubMed / Full text
Preclinical characterization of abemaciclib in hormone receptor positive breast cancer. / 19.09.2017 / PubMed / Full text
Age-dependent human β cell proliferation induced by glucagon-like peptide 1 and calcineurin signaling. / 02.10.2017 / PubMed / Full text

FOXO6

Novel molecular mechanisms for the adaptogenic effects of herbal extracts on isolated brain cells using systems biology. / 15.11.2018 / PubMed / Full text
Introduction to FOXO Biology. / 2019 / PubMed / Full text
FOXO in Neural Cells and Diseases of the Nervous System. / 2018 / PubMed / Full text
FOXO Transcriptional Factors and Long-Term Living. / 2017 / PubMed / Full text

GAA

Mitochondrial damage and senescence phenotype of cells derived from a novel frataxin G127V point mutation mouse model of Friedreich's ataxia. / 27.07.2020 / PubMed / Full text
Age-Related Changes in Serum Guanidinoacetic Acid in Women. / 30.12.2019 / PubMed / Full text
ALKB-8, a 2-Oxoglutarate-Dependent Dioxygenase and S-Adenosine Methionine-Dependent Methyltransferase Modulates Metabolic Events Linked to Lysosome-Related Organelles and Aging in C. elegans. / 2018 / PubMed
SIRT6 histone deacetylase functions as a potential oncogene in human melanoma. / 09.2017 / PubMed / Full text

GAP43

HDAC inhibition leads to age-dependent opposite regenerative effect upon PTEN deletion in rubrospinal axons after SCI. / 06.2020 / PubMed / Full text
Sonic hedgehog regulation of cavernous nerve regeneration and neurite formation in aged pelvic plexus. / 02.2019 / PubMed / Full text
Differential expression of synaptic and interneuron genes in the aging human prefrontal cortex. / 10.2018 / PubMed / Full text
Schwann Cell Phenotype Changes in Aging Human Dental Pulp. / 03.2018 / PubMed / Full text

GAPDH

Age-dependent accumulation of oligomeric SNCA/α-synuclein from impaired degradation in mutant LRRK2 knockin mouse model of Parkinson disease: role for therapeutic activation of chaperone-mediated autophagy (CMA). / 02.2020 / PubMed / Full text
Selection of a Real-Time PCR Housekeeping Gene Panel in Human Endothelial Colony Forming Cells for Cellular Senescence Studies. / 2019 / PubMed / Full text
Age-related changes in mRNA expression of selected surface receptors in lymphocytes of dairy calves. / 03.2018 / PubMed / Full text
Changes in contractile and metabolic parameters of skeletal muscle as rats age from 3 to 12 months. / 12.2017 / PubMed / Full text

GCLM

Silencing Bach1 alters aging-related changes in the expression of Nrf2-regulated genes in primary human bronchial epithelial cells. / 15.09.2019 / PubMed / Full text
Ontogeny and aging of Nrf2 pathway genes in livers of rats. / 15.06.2018 / PubMed / Full text
Sulfur amino acid restriction-induced changes in redox-sensitive proteins are associated with slow protein synthesis rates. / 04.2018 / PubMed / Full text
Aging-related decline in the induction of Nrf2-regulated antioxidant genes in human bronchial epithelial cells. / 04.2018 / PubMed / Full text

GGCT

Blockade of γ-Glutamylcyclotransferase Enhances Docetaxel Growth Inhibition of Prostate Cancer Cells. / 09.2019 / PubMed / Full text
Mechanisms of Tumor Growth Inhibition by Depletion of γ-Glutamylcyclotransferase (GGCT): A Novel Molecular Target for Anticancer Therapy. / 14.07.2018 / PubMed / Full text
Depletion of gamma-glutamylcyclotransferase in cancer cells induces autophagy followed by cellular senescence. / 2018 / PubMed / Full text
Prohibitin-2 is a novel regulator of p21 induced by depletion of γ-glutamylcyclotransferase. / 29.01.2018 / PubMed / Full text

GRK2

G protein-coupled receptor kinase 2 modifies the ability of Caenorhabditis elegans to survive oxidative stress. / 16.10.2020 / PubMed / Full text
G protein coupled receptor kinases modulate Caenorhabditis elegans reactions to heat stresses. / 01.10.2020 / PubMed / Full text
Loss of dynamic regulation of G protein-coupled receptor kinase 2 by nitric oxide leads to cardiovascular dysfunction with aging. / 01.05.2020 / PubMed / Full text
Senescent Cells Differentially Translate Senescence-Related mRNAs Via Ribosome Heterogeneity. / 18.06.2019 / PubMed / Full text

HMGB2

Loss of Endogenous HMGB2 Promotes Cardiac Dysfunction and Pressure Overload-Induced Heart Failure in Mice. / 25.01.2019 / PubMed / Full text
HMGB2 Loss upon Senescence Entry Disrupts Genomic Organization and Induces CTCF Clustering across Cell Types. / 17.05.2018 / PubMed / Full text
Correlations between age, functional status, and the senescence-associated proteins HMGB2 and p16 . / 04.2018 / PubMed / Full text
Transcriptional Repression of High-Mobility Group Box 2 by p21 in Radiation-Induced Senescence. / 30.04.2018 / PubMed / Full text

HMGCR

Cholesterol Homeostasis: An In Silico Investigation into How Aging Disrupts Its Key Hepatic Regulatory Mechanisms. / 30.09.2020 / PubMed / Full text
Artesunate inhibits the mevalonate pathway and promotes glioma cell senescence. / 01.2020 / PubMed / Full text
Reactive oxygen species-induced changes in glucose and lipid metabolism contribute to the accumulation of cholesterol in the liver during aging. / 04.2019 / PubMed / Full text
The Age-dependent Elevation of miR-335-3p Leads to Reduced Cholesterol and Impaired Memory in Brain. / 15.10.2018 / PubMed / Full text

IGFBP2

Intracellular Insulin-like growth factor binding protein 2 (IGFBP2) contributes to the senescence of keratinocytes in psoriasis by stabilizing cytoplasmic p21. / 17.04.2020 / PubMed / Full text
TMT-Based Quantitative Proteomic Analysis Reveals Proteomic Changes Involved in Longevity. / 07.2019 / PubMed / Full text
IGFBP-2 and aging: a 20-year longitudinal study on IGFBP-2, IGF-I, BMI, insulin sensitivity and mortality in an aging population. / 01.02.2019 / PubMed / Full text
Proteomic profiling of follicle fluids after superstimulation in one-month-old lambs. / 02.2018 / PubMed / Full text

IL1B

Aged marrow macrophages expand platelet-biased hematopoietic stem cells via Interleukin1B. / 18.04.2019 / PubMed / Full text
MEF2A alters the proliferation, inflammation-related gene expression profiles and its silencing induces cellular senescence in human coronary endothelial cells. / 18.03.2019 / PubMed / Full text
Measuring the Inflammasome in Oncogene-Induced Senescence. / 2019 / PubMed / Full text
Lower levels of interleukin-1β gene expression are associated with impaired Langerhans' cell migration in aged human skin. / 01.2018 / PubMed / Full text

IMPACT

Load-dependent modulation of alpha oscillations during working memory encoding and retention in young and older adults. / 03.11.2020 / PubMed / Full text
Using Video Telehealth to Deliver Patient-Centered Collaborative Care: The G-IMPACT Pilot. / 31.03.2020 / PubMed / Full text
AGING, HEART RATE VARIABILITY AND METABOLIC IMPACT OF OBESITY. / 09.2019 / PubMed / Full text
Endophytic Bacillus strains isolated from alfalfa (Medicago sativa L.) seeds: enhancing the lifespan of Caenorhabditis elegans. / 03.2019 / PubMed / Full text

IRS2

Effects of Heshouwuyin on gene expression of the insulin/IGF signalling pathway in rat testis and spermatogenic cells. / 12.2020 / PubMed / Full text
Involvement of insulin receptor substrates in cognitive impairment and Alzheimer's disease. / 08.2019 / PubMed / Full text
The senescent status of endothelial cells affects proliferation, inflammatory profile and SOX2 expression in bone marrow-derived mesenchymal stem cells. / 06.2019 / PubMed / Full text
Therapeutic and preventive effects of exercise on cardiometabolic parameters in aging and obese rats. / 02.2019 / PubMed / Full text

JAK1

Irradiation-induced senescence of bone marrow mesenchymal stem cells aggravates osteogenic differentiation dysfunction via paracrine signaling. / 01.05.2020 / PubMed / Full text
The Upregulation of Toll-Like Receptor 3 via Autocrine IFN-β Signaling Drives the Senescence of Human Umbilical Cord Blood-Derived Mesenchymal Stem Cells Through JAK1. / 2019 / PubMed / Full text
Influence of age and renal impairment on the steady state pharmacokinetics of filgotinib, a selective JAK1 inhibitor. / 12.2018 / PubMed / Full text
Immunologic effects of chronic administration of tofacitinib, a Janus kinase inhibitor, in cynomolgus monkeys and rats - Comparison of juvenile and adult responses. / 04.2018 / PubMed / Full text

JUN

Age-Onset Phosphorylation of a Minor Actin Variant Promotes Intestinal Barrier Dysfunction. / 02.12.2019 / PubMed / Full text
1,3,5,8-Tetrahydroxy-9H-xanthen-9-one exerts its antiageing effect through the regulation of stress-response genes and the MAPK signaling pathway. / 09.2019 / PubMed / Full text
Urolithin A Inhibits the Catabolic Effect of TNFα on Nucleus Pulposus Cell and Alleviates Intervertebral Disc Degeneration [i]in vivo[/i]. / 2018 / PubMed / Full text
Schwann cell O-GlcNAcylation promotes peripheral nerve remyelination via attenuation of the AP-1 transcription factor JUN. / 31.07.2018 / PubMed / Full text

KLF14

DNA methylation of the ELOVL2, FHL2, KLF14, C1orf132/MIR29B2C, and TRIM59 genes for age prediction from blood, saliva, and buccal swab samples. / 01.2019 / PubMed / Full text
Proof of concept study of age-dependent DNA methylation markers across different tissues by massive parallel sequencing. / 09.2018 / PubMed / Full text
Chronological age prediction based on DNA methylation: Massive parallel sequencing and random forest regression. / 11.2017 / PubMed / Full text
Detection and evaluation of DNA methylation markers found at SCGN and KLF14 loci to estimate human age. / 11.2017 / PubMed / Full text

LEP

Age- and Sex-Specific Changes in Lower-Limb Muscle Power Throughout the Lifespan. / 18.06.2020 / PubMed / Full text
The Copenhagen Sarcopenia Study: lean mass, strength, power, and physical function in a Danish cohort aged 20-93 years. / 12.2019 / PubMed / Full text
Caregiving for Older Adults with Limited English Proficiency: Transitioning from Hospital to Home. / 09.2019 / PubMed / Full text
Effects of macronutrient intake on the lifespan and fecundity of the marula fruit fly, [i]Ceratitis cosyra[/i] (Tephritidae): Extreme lifespan in a host specialist. / 11.2017 / PubMed / Full text

LTA

Lipoteichoic acid from the cell wall of a heat killed Lactobacillus paracasei D3-5 ameliorates aging-related leaky gut, inflammation and improves physical and cognitive functions: from C. elegans to mice. / 02.2020 / PubMed / Full text
The change of pain classes over time: a latent transition analysis. / 02.2020 / PubMed / Full text
Leisure time activities as mediating variables in functional disability progression: An application of parallel latent growth curve modeling. / 2018 / PubMed / Full text
The Neighborhood Built Environment and Cognitive Function of Older Persons: Results from the Singapore Longitudinal Ageing Study. / 2018 / PubMed / Full text

MAG

Exploration of life satisfaction of Korean people with sensory impairments across the lifespan. / 10.2020 / PubMed / Full text
Omega-3 Monoacylglyceride Effects on Longevity, Mitochondrial Metabolism and Oxidative Stress: Insights from [i]Drosophila melanogaster[/i]. / 16.11.2018 / PubMed / Full text
Glial Sulfatides and Neuronal Complex Gangliosides Are Functionally Interdependent in Maintaining Myelinating Axon Integrity. / 02.01.2019 / PubMed / Full text
Gray Matter Volume and Cognitive Performance During Normal Aging. A Voxel-Based Morphometry Study. / 2018 / PubMed / Full text

MCU

A rare case of Epstein-Barr virus-positive mucocutaneous ulcer that developed into an intestinal obstruction: a case report. / 13.01.2020 / PubMed / Full text
Inhibition of Mitochondrial Calcium Overload by SIRT3 Prevents Obesity- or Age-Related Whitening of Brown Adipose Tissue. / 02.2020 / PubMed / Full text
Cytosolic and mitochondrial Ca concentrations in primary hepatocytes change with ageing and in consequence of an mtDNA mutation. / 09.2019 / PubMed / Full text
The nuclear receptor RXRA controls cellular senescence by regulating calcium signaling. / 12.2018 / PubMed / Full text

MME

Geriatric Opioid Harm Reduction: Interprofessional Student Learning Outcomes. / 01-12.2020 / PubMed / Full text
Effectiveness of local anesthetic injection in geriatric patients following operative management of proximal and diaphyseal femur fracture. / 11.2019 / PubMed / Full text
Membrane metallo-endopeptidase mediates cellular senescence induced by oncogenic PIK3CA accompanied with pro-tumorigenic secretome. / 01.08.2019 / PubMed / Full text
Medial meniscus extrusion increases with age and BMI and is depending on different loading conditions. / 08.2018 / PubMed / Full text

MOS

Effect of mannan oligosaccharides on the microbiota and productivity parameters of Litopenaeus vannamei shrimp under intensive cultivation in Ecuador. / 17.02.2020 / PubMed / Full text
Predictors of health-related quality of life among older adults living with HIV in Thailand: results from the baseline and follow-up surveys. / 23.12.2019 / PubMed / Full text
Comparison of health-related quality of life between the Han and Yi ethnicity elderly in the Yi autonomous areas of Yunnan Province. / 25.11.2019 / PubMed / Full text
Mannan oligosaccharide increases the growth performance, immunity and resistance capability against Vibro Parahemolyticus in juvenile abalone Haliotis discus hannai Ino. / 11.2019 / PubMed / Full text

MRE11

Chromosomal alterations among age-related haematopoietic clones in Japan. / 08.2020 / PubMed / Full text
Mechanistic link between DNA damage sensing, repairing and signaling factors and immune signaling. / 2019 / PubMed / Full text
The activated DNA double-strand break repair pathway in cumulus cells from aging patients may be used as a convincing predictor of poor outcomes after in vitro fertilization-embryo transfer treatment. / 2018 / PubMed / Full text
Transactivation domain of p53 regulates DNA repair and integrity in human iPS cells. / 01.09.2018 / PubMed / Full text

NEDD8

Targeting Protein Neddylation for Cancer Therapy. / 2020 / PubMed / Full text
Effective targeting of the ubiquitin-like modifier NEDD8 for lung adenocarcinoma treatment. / 08.2020 / PubMed / Full text
Pevonedistat targeted therapy inhibits canine melanoma cell growth through induction of DNA re-replication and senescence. / 09.2020 / PubMed / Full text
Protein neddylation and its alterations in human cancers for targeted therapy. / 04.2018 / PubMed / Full text

NNT

Yoga, Health-Related Quality of Life and Mental Well-Being: A Re-analysis of a Meta-analysis Using the Quality Effects Model. / 16.09.2020 / PubMed / Full text
Statins After Myocardial Infarction in the Oldest: A Cohort Study in the Clinical Practice Research Datalink Database. / 02.2020 / PubMed / Full text
Years of Life Lost for Older Patients After Colorectal Cancer Diagnosis. / 08.2019 / PubMed / Full text
Nicotinamide nucleotide transhydrogenase is required for brain mitochondrial redox balance under hampered energy substrate metabolism and high-fat diet. / 12.2018 / PubMed / Full text

NOTCH1

[How Does Aging Contribute to Cancer?] / 09.2020 / PubMed
H19 is not hypomethylated or upregulated with age or sex in the aortic valves of mice. / 10.2019 / PubMed / Full text
Age-related remodelling of oesophageal epithelia by mutated cancer drivers. / 01.2019 / PubMed / Full text
Dynamic regulation of NOTCH1 activation and Notch ligand expression in human thymus development. / 13.08.2018 / PubMed / Full text

NPC1

Evaluation of age of death in Niemann-Pick disease, type C: Utility of disease support group websites to understand natural history. / 04.2019 / PubMed / Full text
AAV9 intracerebroventricular gene therapy improves lifespan, locomotor function and pathology in a mouse model of Niemann-Pick type C1 disease. / 01.09.2018 / PubMed / Full text
SIRT6 histone deacetylase functions as a potential oncogene in human melanoma. / 09.2017 / PubMed / Full text
The adenosine A receptor agonist T1-11 ameliorates neurovisceral symptoms and extends the lifespan of a mouse model of Niemann-Pick type C disease. / 02.2018 / PubMed / Full text

NPS

Cortical β-amyloid burden, neuropsychiatric symptoms, and cognitive status: the Mayo Clinic Study of Aging. / 28.03.2019 / PubMed / Full text
Mild Behavioral Impairment as a Marker of Cognitive Decline in Cognitively Normal Older Adults. / 08.2019 / PubMed / Full text
The course of neuropsychiatric symptoms in patients with dementia in primary care. / 31.07.2019 / PubMed / Full text
Serum calcium levels and neuropsychological performance in depression and matched healthy controls: Reversal of correlation a marker of the aging cognitive clock? / 05.2018 / PubMed / Full text

NRAS

Senescent cholangiocytes release extracellular vesicles that alter target cell phenotype via the epidermal growth factor receptor. / 10.2020 / PubMed / Full text
STAT3 Relays a Differential Response to Melanoma-Associated [i]NRAS[/i] Mutations. / 02.01.2020 / PubMed / Full text
Cooperation of Dnmt3a R878H with Nras G12D promotes leukemogenesis in knock-in mice: a pilot study. / 08.11.2019 / PubMed / Full text
Sequential acquisition of mutations in myelodysplastic syndromes. / 2017 / PubMed / Full text

OTC

Age and growth of stocked juvenile Shoal Bass in a tailwater: Environmental variation and accuracy of daily age estimates. / 2019 / PubMed / Full text
Comprehensive characterization of ureagenesis in the spf mouse, a model of human ornithine transcarbamylase deficiency, reveals age-dependency of ammonia detoxification. / 11.2019 / PubMed / Full text
Patterns and Perceptions of Self-Management for Osteoarthritis Pain in African American Older Adults. / 01.08.2019 / PubMed / Full text
Use of over the counter products in older cardiovascular patients admitted to a tertiary care center in USA. / 04.12.2018 / PubMed / Full text

PARP1

Topological DNA damage, telomere attrition and T cell senescence during chronic viral infections. / 2019 / PubMed / Full text
PARP1 inhibitor (PJ34) improves the function of aging-induced endothelial progenitor cells by preserving intracellular NAD levels and increasing SIRT1 activity. / 23.08.2018 / PubMed / Full text
Maternal high calorie diet induces mitochondrial dysfunction and senescence phenotype in subcutaneous fat of newborn mice. / 13.10.2017 / PubMed / Full text
Acute telomerase components depletion triggers oxidative stress as an early event previous to telomeric shortening. / 04.2018 / PubMed / Full text

PCSK9

Lipoprotein removal mechanisms and aging: implications for the cardiovascular health of the elderly. / 04.2020 / PubMed / Full text
The role of proprotein convertase subtilisin-kexin type 9 (PCSK9) in the vascular aging process - is there a link? / 10.2019 / PubMed / Full text
PCSK9 Inhibitors Show Value for Patients and the US Health Care System. / 12.2017 / PubMed / Full text
Association between lipoprotein (a) and proprotein convertase substilisin/kexin type 9 in patients with heterozygous familial hypercholesterolemia: A case-control study. / 02.2018 / PubMed / Full text

PDK1

Inhibition of 3-phosphoinositide-dependent protein kinase 1 (PDK1) can revert cellular senescence in human dermal fibroblasts. / 08.12.2020 / PubMed / Full text
The Impact of the PI3K/Akt Signaling Pathway in Anxiety and Working Memory in Young and Middle-Aged PDK1 K465E Knock-In Mice. / 2020 / PubMed / Full text
Vps15 is critical to mediate autophagy in AngII treated HUVECs probably by PDK1/PKC signaling pathway. / 15.09.2019 / PubMed / Full text
Acupuncture Administration Improves Cognitive Functions and Alleviates Inflammation and Nuclear Damage by Regulating Phosphatidylinositol 3 Kinase (PI3K)/Phosphoinositol-Dependent Kinase 1 (PDK1)/Novel Protein Kinase C (nPKC)/Rac 1 Signaling Pathway in Senescence-Accelerated Prone 8 (SAM-P8) Mice. / 01.06.2019 / PubMed / Full text

PGF

Long-Term Aspirin Administration Has No Effect on Erectile Function: Evidence from Adult Rats and Ageing Rat Model. / 28.05.2019 / PubMed / Full text
In Vitro and In Vivo Antioxidant Activities of the Flowers and Leaves from Paeonia rockii and Identification of Their Antioxidant Constituents by UHPLC-ESI-HRMS via Pre-Column DPPH Reaction. / 12.02.2018 / PubMed / Full text
Redox cycling induces spermptosis and necrosis in stallion spermatozoa while the hydroxyl radical (OH•) only induces spermptosis. / 02.2018 / PubMed / Full text
Advanced age in mares affects endometrial secretion of arachidonic acid metabolites during equine subclinical endometritis. / 11.2017 / PubMed / Full text

PICALM

Genetic Association between Alzheimer's Disease Risk Variant of the PICALM Gene and Auditory Event-Related Potentials in Aging. / 09.2018 / PubMed / Full text
Integrative transcriptome analyses of the aging brain implicate altered splicing in Alzheimer's disease susceptibility. / 11.2018 / PubMed / Full text
Recent studies on cellular and molecular mechanisms in Alzheimer's disease: focus on epigenetic factors and histone deacetylase. / 28.03.2018 / PubMed / Full text
Alterations in endocytic protein expression with increasing age in the transgenic APP695 V717I London mouse model of amyloid pathology: implications for Alzheimer's disease. / 18.10.2017 / PubMed / Full text

PIN1

Brain somatic mutations observed in Alzheimer's disease associated with aging and dysregulation of tau phosphorylation. / 12.07.2019 / PubMed / Full text
Class XI Myosins Contribute to Auxin Response and Senescence-Induced Cell Death in [i]Arabidopsis[/i]. / 2018 / PubMed / Full text
Effects of Melatonin and Its Underlying Mechanism on Ethanol-Stimulated Senescence and Osteoclastic Differentiation in Human Periodontal Ligament Cells and Cementoblasts. / 12.06.2018 / PubMed / Full text
Integrative Analysis of Hippocampus Gene Expression Profiles Identifies Network Alterations in Aging and Alzheimer's Disease. / 2018 / PubMed / Full text

PNN

Hyaluronan degradation and release of a hyaluronan-aggrecan complex from perineuronal nets in the aged mouse brain. / 28.11.2020 / PubMed / Full text
Inhibition of Semaphorin3A Promotes Ocular Dominance Plasticity in the Adult Rat Visual Cortex. / 09.2019 / PubMed / Full text
Proteomics and metabolomics identify molecular mechanisms of aging potentially predisposing for chronic lymphocytic leukemia. / 02.2018 / PubMed / Full text
Age-dependent and region-specific alteration of parvalbumin neurons and perineuronal nets in the mouse cerebral cortex. / 01.2018 / PubMed / Full text

POLD1

Epigenetic signatures of Werner syndrome occur early in life and are distinct from normal epigenetic aging processes. / 10.2019 / PubMed / Full text
POLD1 deficiency is involved in cognitive function impairment in AD patients and SAMP8 mice. / 06.2019 / PubMed / Full text
E2F1 mediates the downregulation of POLD1 in replicative senescence. / 07.2019 / PubMed / Full text
Mandibuloacral dysplasia: A premature ageing disease with aspects of physiological ageing. / 03.2018 / PubMed / Full text

POLG

Maternal ageing impairs mitochondrial DNA kinetics during early embryogenesis in mice. / 08.07.2019 / PubMed / Full text
Parkin does not prevent accelerated cardiac aging in mitochondrial DNA mutator mice. / 16.04.2019 / PubMed / Full text
The effects of AICAR and rapamycin on mitochondrial function in immortalized mitochondrial DNA mutator murine embryonic fibroblasts. / 16.11.2018 / PubMed / Full text
Impact of exercise on oocyte quality in the POLG mitochondrial DNA mutator mouse. / 08.2018 / PubMed / Full text

RAD51

Loss of Slug Compromises DNA Damage Repair and Accelerates Stem Cell Aging in Mammary Epithelium. / 09.07.2019 / PubMed / Full text
Quantitative assessment of changes in cell growth, size and morphology during telomere-initiated cellular senescence in Saccharomyces cerevisiae. / 01.08.2019 / PubMed / Full text
Mechanistic link between DNA damage sensing, repairing and signaling factors and immune signaling. / 2019 / PubMed / Full text
The activated DNA double-strand break repair pathway in cumulus cells from aging patients may be used as a convincing predictor of poor outcomes after in vitro fertilization-embryo transfer treatment. / 2018 / PubMed / Full text

SATB1

Loss of SATB1 Induces p21-Dependent Cellular Senescence in Post-mitotic Dopaminergic Neurons. / 03.10.2019 / PubMed / Full text
Transcriptomic analysis of human IL-7 receptor alpha and effector memory CD8 T cells reveals an age-associated signature linked to influenza vaccine response in older adults. / 08.2019 / PubMed / Full text
Divergent SATB1 expression across human life span and tissue compartments. / 05.2019 / PubMed / Full text
Changes in expression of special AT-rich sequence binding protein 1 and phosphatase and tensin homologue in kidneys of diabetic rats during ageing. / 01.10.2018 / PubMed / Full text

SET

Chromatin Modifiers SET-25 and SET-32 Are Required for Establishment but Not Long-Term Maintenance of Transgenerational Epigenetic Inheritance. / 20.11.2018 / PubMed / Full text
SET-9 and SET-26 are H3K4me3 readers and play critical roles in germline development and longevity. / 01.05.2018 / PubMed / Full text
Muscle-Specific Histone H3K36 Dimethyltransferase SET-18 Shortens Lifespan of Caenorhabditis elegans by Repressing daf-16a Expression. / 06.03.2018 / PubMed / Full text
Assessing efficacy of day 3 embryo time-lapse algorithms retrospectively: impacts of dataset type and confounding factors. / 09.2019 / PubMed / Full text

SLA

Vaccination of aged mice with adjuvanted recombinant influenza nucleoprotein enhances protective immunity. / 14.07.2020 / PubMed / Full text
Mechanical Anisotropy and Surface Roughness in Additively Manufactured Parts Fabricated by Stereolithography (SLA) Using Statistical Analysis. / 30.05.2020 / PubMed / Full text
The Effect of Age of Titanium Dental Implants on Implant Survival and Marginal Bone Resorption: A 5-Year Retrospective Follow-Up Study. / 01.10.2020 / PubMed / Full text
"Spirometric" lung age reference equations: A narrative review. / 01.2018 / PubMed / Full text

SMS

Does a Live Performance Impact Synchronization to Musical Rhythm in Cognitively Impaired Elderly? / 2020 / PubMed / Full text
Testing the effectiveness of physical activity advice delivered via text messaging vs. human phone advisors in a Latino population: The On The Move randomized controlled trial design and methods. / 08.2020 / PubMed / Full text
Mobile Health Interventions for Physical Activity, Sedentary Behavior, and Sleep in Adults Aged 50 Years and Older: A Systematic Literature Review. / 01.08.2019 / PubMed / Full text
Senescence-messaging secretome factors trigger premature senescence in human endometrium-derived stem cells. / 19.02.2018 / PubMed / Full text

SOD3

Prenatal hypoxia affected endothelium-dependent vasodilation in mesenteric arteries of aged offspring via increased oxidative stress. / 06.2019 / PubMed / Full text
Superoxide dismutase activity is significantly lower in end-stage osteoarthritic cartilage than non-osteoarthritic cartilage. / 2018 / PubMed / Full text
In silico analysis and molecular dynamics simulation of human superoxide dismutase 3 (SOD3) genetic variants. / 03.2019 / PubMed / Full text
Proteomic profiling of follicle fluids after superstimulation in one-month-old lambs. / 02.2018 / PubMed / Full text

SOX9

Positive Effects of a Young Systemic Environment and High Growth Differentiation Factor 11 Levels on Chondrocyte Proliferation and Cartilage Matrix Synthesis in Old Mice. / 07.2020 / PubMed / Full text
Epigenetic Mechanisms Underlying the Aging of Articular Cartilage and Osteoarthritis. / 2019 / PubMed / Full text
Co-culturing nucleus pulposus mesenchymal stem cells with notochordal cell-rich nucleus pulposus explants attenuates tumor necrosis factor-α-induced senescence. / 26.06.2018 / PubMed / Full text
Role of CD133 Molecule in Wnt Response and Renal Repair. / 03.2018 / PubMed / Full text

TIGIT

Impaired Cytolytic Activity and Loss of Clonal Neoantigens in Elderly Patients With Lung Adenocarcinoma. / 05.2019 / PubMed / Full text
Multivariate Computational Analysis of Gamma Delta T Cell Inhibitory Receptor Signatures Reveals the Divergence of Healthy and ART-Suppressed HIV+ Aging. / 2018 / PubMed / Full text
Characterization of Blimp-1 function in effector regulatory T cells. / 07.2018 / PubMed / Full text
T-cell Immunoglobulin and ITIM Domain Contributes to CD8 T-cell Immunosenescence. / 04.2018 / PubMed / Full text

TRPA1

Important regulatory function of transient receptor potential ankyrin 1 receptors in age-related learning and memory alterations of mice. / 10.2019 / PubMed / Full text
Aging of mouse intervertebral disc and association with back pain. / 06.2019 / PubMed / Full text
Congeneric variability in lifespan extension and onset of senescence suggest active regulation of aging in response to low temperature. / 12.2018 / PubMed / Full text
A comparative study on the therapeutic effect of TRPV1, TRPA1, and TRPM8 agonists on swallowing dysfunction associated with aging and neurological diseases. / 02.2018 / PubMed / Full text

TRPV4

TRPV4 receptor as a functional sensory molecule in bladder urothelium: Stretch-independent, tissue-specific actions and pathological implications. / 01.2020 / PubMed / Full text
Exercise restores impaired endothelium-derived hyperpolarizing factor-mediated vasodilation in aged rat aortic arteries via the TRPV4-K 2.3 signaling complex. / 2019 / PubMed / Full text
Autonomic dysregulation at multiple sites is implicated in age-associated underactive bladder in female mice. / 06.2019 / PubMed / Full text
Reduced bladder responses to capsaicin and GSK-1016790A in retired-breeder female rats with diminished volume sensitivity. / 01.11.2018 / PubMed / Full text

TSC2

AMPK/TSC2/mTOR pathway regulates replicative senescence of human vascular smooth muscle cells. / 12.2018 / PubMed / Full text
Autophagy mediators (FOXO1, SESN3 and TSC2) in Lewy body disease and aging. / 25.09.2018 / PubMed / Full text
FTO is involved in Alzheimer's disease by targeting TSC1-mTOR-Tau signaling. / 25.03.2018 / PubMed / Full text
Postnatal reduction of tuberous sclerosis complex 1 expression in astrocytes and neurons causes seizures in an age-dependent manner. / 12.2017 / PubMed / Full text

A2M

Age-Dependent Variation in Glycosylation Features of Alpha-2-Macroglobulin. / 12.2019 / PubMed / Full text
MMP2-A2M interaction increases ECM accumulation in aged rat kidney and its modulation by calorie restriction. / 19.01.2018 / PubMed / Full text
SPARCL1 Accelerates Symptom Onset in Alzheimer's Disease and Influences Brain Structure and Function During Aging. / 2018 / PubMed / Full text

ABCA7

New genetic players in late-onset Alzheimer's disease: Findings of genome-wide association studies. / 08.2018 / PubMed / Full text
Whole-Exome Sequencing of an Exceptional Longevity Cohort. / 16.08.2019 / PubMed / Full text
Recent studies on cellular and molecular mechanisms in Alzheimer's disease: focus on epigenetic factors and histone deacetylase. / 28.03.2018 / PubMed / Full text

ABCG2

Contribution of senescence in human endometrial stromal cells during proliferative phase to embryo receptivity†. / 23.06.2020 / PubMed / Full text
ABCG2 rs2231142 variant in hyperuricemia is modified by SLC2A9 and SLC22A12 polymorphisms and cardiovascular risk factors in an elderly community-dwelling population. / 17.03.2020 / PubMed / Full text
Morphological and immunohistochemical characteristics of the equine corneal epithelium. / 11.2019 / PubMed / Full text

ACLY

In S. cerevisiae hydroxycitric acid antagonizes chronological aging and apoptosis regardless of citrate lyase. / 10.2020 / PubMed / Full text
Dietary methionine increased the lipid accumulation in juvenile tiger puffer Takifugu rubripes. / 04.2019 / PubMed / Full text
Spermidine reduces cancer-related mortality in humans. / 02.2019 / PubMed / Full text

ACTN3

The Role of Genetic Profile in Functional Performance Adaptations to Exercise Training or Physical Activity: A Systematic Review of the Literature. / 01.08.2019 / PubMed / Full text
Is evolutionary loss our gain? The role of ACTN3 p.Arg577Ter (R577X) genotype in athletic performance, ageing, and disease. / 12.2018 / PubMed / Full text
ACTN3 genotype and physical function and frailty in an elderly Chinese population: the Rugao Longevity and Ageing Study. / 01.05.2018 / PubMed / Full text

ADM

Assessment of age-related differences in decomposition-based quantitative EMG in the intrinsic hand muscles: A multivariate approach. / 09.2020 / PubMed / Full text
Evaluation of transcriptional levels of the natriuretic peptides, endothelin-1, adrenomedullin, their receptors and long non-coding RNAs in rat cardiac tissue as cardiovascular biomarkers of aging. / 01.2020 / PubMed / Full text
Development and physiological effects of an artificial diet for Wolbachia-infected Aedes aegypti. / 16.11.2017 / PubMed / Full text

AGA

Relationship between androgenic alopecia and white matter hyperintensities in apparently healthy subjects. / 04.2020 / PubMed / Full text
ALKB-8, a 2-Oxoglutarate-Dependent Dioxygenase and S-Adenosine Methionine-Dependent Methyltransferase Modulates Metabolic Events Linked to Lysosome-Related Organelles and Aging in C. elegans. / 2018 / PubMed
The Impact of Being Born Preterm or Small for Gestational Age on Early Vascular Aging in Adolescents. / 10.2018 / PubMed / Full text

ALB

Effects of Age on Inflammatory Profiles and Nutrition/Energy Metabolism in Domestic Cats. / 2020 / PubMed / Full text
Blood Chemistry Reference Values for Free-Ranging Asiatic Black Bears ( Ursus thibetanus) by Season, Age, and Sex. / 07.2018 / PubMed / Full text
Higher serum albumin was related with diabetes incidence and the impact of BMI changes: Based on cohort study of 18,384 Chinese male elderly. / 12.2017 / PubMed / Full text

ASXL1

ASXL1 mutation in clonal hematopoiesis. / 03.2020 / PubMed / Full text
[Role of ASXL1 mutations in hematological disorders]. / 2019 / PubMed / Full text
Clonal hematopoiesis: Genes and underlying mechanisms in cardiovascular disease development. / 06.2019 / PubMed / Full text

ATRX

ATRX-DAXX Complex Expression Levels and Telomere Length in Normal Young and Elder Autopsy Human Brains. / 09.2019 / PubMed / Full text
Inactivation of hepatic ATRX in [i]Atrx[/i] Foxg1cre mice prevents reversal of aging-like phenotypes by thyroxine. / 07.06.2018 / PubMed / Full text
Mechanistic understanding of the role of ATRX in senescence provides new insight for combinatorial therapies with CDK4 inhibitors. / 2018 / PubMed / Full text

BAD

I imidazoline receptor modulation protects aged SAMP8 mice against cognitive decline by suppressing the calcineurin pathway. / 31.10.2020 / PubMed / Full text
Xanthohumol exerts protective effects in liver alterations associated with aging. / 03.2019 / PubMed / Full text
Protective effect of xanthohumol against age-related brain damage. / 11.2017 / PubMed / Full text

BATF

LncRNA-ES3 inhibition by Bhlhe40 is involved in high glucose-induced calcification/senescence of vascular smooth muscle cells. / 08.2020 / PubMed / Full text
Transcription factor networks in aged naïve CD4 T cells bias lineage differentiation. / 08.2019 / PubMed / Full text
Transcriptomic analysis of human IL-7 receptor alpha and effector memory CD8 T cells reveals an age-associated signature linked to influenza vaccine response in older adults. / 08.2019 / PubMed / Full text

BLM

[Olmesartan inhibits age-associated migration and invasion of human aortic vascular smooth muscle cells by upregulating miR-3133 axis]. / 30.04.2020 / PubMed / Full text
Genomic instability and DNA replication defects in progeroid syndromes. / 31.12.2018 / PubMed / Full text
Human RecQL4 helicase plays multifaceted roles in the genomic stability of normal and cancer cells. / 28.01.2018 / PubMed / Full text

BMI1

Senescence Induced by BMI1 Inhibition Is a Therapeutic Vulnerability in H3K27M-Mutant DIPG. / 20.10.2020 / PubMed / Full text
microRNA-31 inhibition partially ameliorates the deficiency of bone marrow stromal cells from cleidocranial dysplasia. / 06.2019 / PubMed / Full text
Timosaponin A-III inhibits oncogenic phenotype via regulation of PcG protein BMI1 in breast cancer cells. / 07.2018 / PubMed / Full text

BMP2

Interleukin-1β-Induced Senescence Promotes Osteoblastic Transition of Vascular Smooth Muscle Cells. / 2020 / PubMed / Full text
Long noncoding RNA Bmncr regulates mesenchymal stem cell fate during skeletal aging. / 03.12.2018 / PubMed / Full text
Synthesis of Extracellular Pyrophosphate Increases in Vascular Smooth Muscle Cells During Phosphate-Induced Calcification. / 09.2018 / PubMed / Full text

BMP4

Direct reprogramming of human smooth muscle and vascular endothelial cells reveals defects associated with aging and Hutchinson-Gilford progeria syndrome. / 08.09.2020 / PubMed / Full text
Interplay between Follistatin, Activin A, and BMP4 Signaling Regulates Postnatal Thymic Epithelial Progenitor Cell Differentiation during Aging. / 25.06.2019 / PubMed / Full text
Centenarians Overexpress Pluripotency-Related Genes. / 16.08.2019 / PubMed / Full text

BPI

High TARC plasma levels confer protection to long living individuals by inducing M2 profile. / 01.2021 / PubMed / Full text
Circulating BPIFB4 Levels Associate With and Influence the Abundance of Reparative Monocytes and Macrophages in Long Living Individuals. / 2020 / PubMed / Full text
The effect of postural deformities on back function and pain in patients with Parkinson's disease. / 2019 / PubMed / Full text

CCL3

Microglial translational profiling reveals a convergent APOE pathway from aging, amyloid, and tau. / 03.09.2018 / PubMed / Full text
Time-Dependent Changes in Local and Serum Levels of Inflammatory Cytokines as Markers for Incised Wound Aging of Skeletal Muscles. / 05.2018 / PubMed / Full text
Age-related pro-inflammatory and pro-angiogenic changes in human aqueous humor. / 2018 / PubMed / Full text

CCN1

Sodium tanshinone IIA sulfonate restrains fibrogenesis through induction of senescence in mice with induced deep endometriosis. / 09.2020 / PubMed / Full text
Inhibition of cellular communication network factor 1 (CCN1)-driven senescence slows down cartilage inflammaging and osteoarthritis. / 10.2020 / PubMed / Full text
The senescence-associated matricellular protein CCN1 in plasma of human subjects with idiopathic pulmonary fibrosis. / 01.2020 / PubMed / Full text

CCNB1

Antioxidant hesperetin improves the quality of porcine oocytes during aging in vitro. / 01.2019 / PubMed / Full text
Effect of CCNB1 silencing on cell cycle, senescence, and apoptosis through the p53 signaling pathway in pancreatic cancer. / 01.2018 / PubMed / Full text
Hypoxia Upregulates Mitotic Cyclins Which Contribute to the Multipotency of Human Mesenchymal Stem Cells by Expanding Proliferation Lifespan. / 31.03.2018 / PubMed / Full text

CCR5

[Enhancement can do harm]. / 08-09.2019 / PubMed / Full text
CCR5-∆32 is deleterious in the homozygous state in humans. / 06.2019 / PubMed / Full text
CCR5 chemokine receptor gene polymorphisms in ocular toxoplasmosis. / 02.2018 / PubMed / Full text

CD24

CD24 expression indicates healthier phenotype and less tendency of cellular senescence in human nucleus pulposus cells. / 12.2019 / PubMed / Full text
Innate and adaptive immune dysregulation in critically ill ICU patients. / 05.07.2018 / PubMed / Full text
Some chemotherapeutics-treated colon cancer cells display a specific phenotype being a combination of stem-like and senescent cell features. / 02.01.2018 / PubMed / Full text

CD81

Ovarian aging increases small extracellular vesicle CD81 release in human follicular fluid and influences miRNA profiles. / 17.06.2020 / PubMed / Full text
Older Adults with Physical Frailty and Sarcopenia Show Increased Levels of Circulating Small Extracellular Vesicles with a Specific Mitochondrial Signature. / 15.04.2020 / PubMed / Full text
Increased production of functional small extracellular vesicles in senescent endothelial cells. / 04.2020 / PubMed / Full text

CD9

Exosomal Notch3 from high glucose-stimulated endothelial cells regulates vascular smooth muscle cells calcification/aging. / 01.09.2019 / PubMed / Full text
Effects of RSC96 Schwann Cell-Derived Exosomes on Proliferation, Senescence, and Apoptosis of Dorsal Root Ganglion Cells In Vitro. / 02.11.2018 / PubMed / Full text
Identification of functionally distinct fibro-inflammatory and adipogenic stromal subpopulations in visceral adipose tissue of adult mice. / 28.09.2018 / PubMed / Full text

CDC42

Effects of age-dependent changes in cell size on endothelial cell proliferation and senescence through YAP1. / 05.09.2019 / PubMed / Full text
Re-exploring the core genes and modules in the human frontal cortex during chronological aging: insights from network-based analysis of transcriptomic studies. / 20.10.2018 / PubMed / Full text
The relationship between reproductive and biochemical ageing at the time of the menopausal transition. / 11.2017 / PubMed / Full text

CDK5

Age-related hyperinsulinemia leads to insulin resistance in neurons and cell-cycle-induced senescence. / 11.2019 / PubMed / Full text
CK2 inhibition protects white matter from ischemic injury. / 20.11.2018 / PubMed / Full text
CK2 inhibition confers functional protection to young and aging axons against ischemia by differentially regulating the CDK5 and AKT signaling pathways. / 06.2019 / PubMed / Full text

COMP

Effect of circadian rhythm, age, training and acute lameness on serum concentrations of cartilage oligomeric matrix protein (COMP) neo-epitope in horses. / 09.2019 / PubMed / Full text
Genetic overexpression of COMP-Ang1 impairs BM microenvironment and induces senescence of BM HSCs. / 15.05.2018 / PubMed / Full text
Longitudinal Twin Study of Subjective Health: Differences in Genetic and Environmental Components of Variance Across Age and Sex. / 01.01.2020 / PubMed / Full text

CPT1C

Carnitine palmitoyltransferase 1C reverses cellular senescence of MRC-5 fibroblasts via regulating lipid accumulation and mitochondrial function. / 02.2021 / PubMed / Full text
Carnitine palmitoyltransferase 1C contributes to progressive cellular senescence. / 14.04.2020 / PubMed / Full text
Effects of carnitine palmitoyltransferases on cancer cellular senescence. / 02.2019 / PubMed / Full text

CRY1

Karyopherin Alpha 2-Expressing Pancreatic Duct Glands and Intra-Islet Ducts in Aged Diabetic C414A-Mutant-CRY1 Transgenic Mice. / 2019 / PubMed / Full text
Investigating circadian clock gene expression in human tendon biopsies from acute exercise and immobilization studies. / 06.2019 / PubMed / Full text
Is the aging human ovary still ticking?: Expression of clock-genes in luteinized granulosa cells of young and older women. / 21.11.2018 / PubMed / Full text

CTCF

New targeted approaches for epigenetic age predictions. / 24.06.2020 / PubMed / Full text
Genetic Insights Into Frailty: Association of 9p21-23 Locus With Frailty. / 2018 / PubMed / Full text
HMGB2 Loss upon Senescence Entry Disrupts Genomic Organization and Induces CTCF Clustering across Cell Types. / 17.05.2018 / PubMed / Full text

CTH

Anterior Cingulate Structure and Perfusion is Associated with Cerebrospinal Fluid Tau among Cognitively Normal Older Adult APOEɛ4 Carriers. / 2020 / PubMed / Full text
Curious CXR. / 07.2019 / PubMed / Full text
Mechanochemical Catalytic Transfer Hydrogenation of Aromatic Nitro Derivatives. / 30.11.2018 / PubMed / Full text

CTNNB1

[i]TP53[/i] Tumor-suppressor Gene Plays a Key Role in IGF1 Signaling Pathway Related to the Aging of Human Melanocytes. / 05.2019 / PubMed / Full text
Identification of key genes and transcription factors in aging mesenchymal stem cells by DNA microarray data. / 15.04.2019 / PubMed / Full text
Proteomic profiling of follicle fluids after superstimulation in one-month-old lambs. / 02.2018 / PubMed / Full text

CTSB

Myocardial cathepsin D is downregulated in sudden cardiac death. / 2020 / PubMed / Full text
A Free Radical-Generating System Regulates Amyloid Oligomers: Involvement of Cathepsin B. / 2018 / PubMed / Full text
SIRT6 histone deacetylase functions as a potential oncogene in human melanoma. / 09.2017 / PubMed / Full text

CYP2J2

The effects of endothelium-specific CYP2J2 overexpression on the attenuation of retinal ganglion cell apoptosis in a glaucoma rat model. / 10.2019 / PubMed / Full text
Regional vulnerability to lipoxidative damage and inflammation in normal human brain aging. / 01.10.2018 / PubMed / Full text
Endothelium-specific CYP2J2 overexpression attenuates age-related insulin resistance. / 04.2018 / PubMed / Full text

DCT

Changes in expression of special AT-rich sequence binding protein 1 and phosphatase and tensin homologue in kidneys of diabetic rats during ageing. / 01.10.2018 / PubMed / Full text
Evaluation of the NAL Dynamic Conversations Test in older listeners with hearing loss. / 03.2018 / PubMed / Full text
Dihydrocapsiate improved age-associated impairments in mice by increasing energy expenditure. / 01.11.2017 / PubMed / Full text

DDC

N-Acetyl Cysteine Attenuates the Sarcopenia and Muscle Apoptosis Induced by Chronic Liver Disease. / 2019 / PubMed / Full text
Aging-Related Expression of Twinfilin-1 Regulates Cholangiocyte Biological Response to Injury. / 09.2019 / PubMed / Full text
Life History of Parthenolecanium spp. (Hemiptera: Coccidae) in Urban Landscapes of the Southeastern United States. / 01.08.2017 / PubMed / Full text

DDO

New insights on the influence of free d-aspartate metabolism in the mammalian brain during prenatal and postnatal life. / 10.2020 / PubMed / Full text
Free d-aspartate triggers NMDA receptor-dependent cell death in primary cortical neurons and perturbs JNK activation, Tau phosphorylation, and protein SUMOylation in the cerebral cortex of mice lacking d-aspartate oxidase activity. / 07.2019 / PubMed / Full text
Secreted d-aspartate oxidase functions in C. elegans reproduction and development. / 01.2019 / PubMed / Full text

DKK1

Low Serum Levels of DKK2 Predict Incident Low-Impact Fracture in Older Women. / 07.2019 / PubMed / Full text
Involvement of p38 in Age-Related Decline in Adult Neurogenesis via Modulation of Wnt Signaling. / 11.06.2019 / PubMed / Full text
[Role and alterations of DNA methylation during the aging and cancer]. / 01.2018 / PubMed / Full text

DLD

A preliminary study of cerebral blood flow, aging and dementia in people with Down syndrome. / 12.2020 / PubMed / Full text
Premature senescence activation in DLD-1 colorectal cancer cells through adjuvant therapy to induce a miRNA profile modulating cellular death. / 08.2018 / PubMed / Full text
Immature Auditory Evoked Potentials in Children With Moderate-Severe Developmental Language Disorder. / 13.07.2018 / PubMed / Full text

DNMT3B

Alcohol Extracts From [i]Ganoderma lucidum[/i] Delay the Progress of Alzheimer's Disease by Regulating DNA Methylation in Rodents. / 2019 / PubMed / Full text
Human iPSC-derived MSCs (iMSCs) from aged individuals acquire a rejuvenation signature. / 18.03.2019 / PubMed / Full text
Effects of Parental Aging During Embryo Development and Adult Life: The Case of Nothobranchius furzeri. / 04.2018 / PubMed / Full text

EP300

Identification of key genes and transcription factors in aging mesenchymal stem cells by DNA microarray data. / 15.04.2019 / PubMed / Full text
Aspirin-another caloric-restriction mimetic. / 2018 / PubMed / Full text
Aspirin Recapitulates Features of Caloric Restriction. / 27.02.2018 / PubMed / Full text

FABP3

FABP3-mediated membrane lipid saturation alters fluidity and induces ER stress in skeletal muscle with aging. / 09.11.2020 / PubMed / Full text
Autophagy receptor OPTN (optineurin) regulates mesenchymal stem cell fate and bone-fat balance during aging by clearing FABP3. / 04.11.2020 / PubMed / Full text
Myokines as biomarkers of frailty and cardiovascular disease risk in females. / 05.2020 / PubMed / Full text

FIS1

A mitochondrial FUNDC1/HSC70 interaction organizes the proteostatic stress response at the risk of cell morbidity. / 01.02.2019 / PubMed / Full text
Increased Degradation Rates in the Components of the Mitochondrial Oxidative Phosphorylation Chain in the Cerebellum of Old Mice. / 2018 / PubMed / Full text
Proteomics and metabolomics identify molecular mechanisms of aging potentially predisposing for chronic lymphocytic leukemia. / 02.2018 / PubMed / Full text

FOS

Muscle atrophy-related myotube-derived exosomal microRNA in neuronal dysfunction: Targeting both coding and long noncoding RNAs. / 05.2020 / PubMed / Full text
Dietary Fructooligosaccharide and Glucomannan Alter Gut Microbiota and Improve Bone Metabolism in Senescence-Accelerated Mouse. / 23.01.2019 / PubMed / Full text
Novel molecular mechanisms for the adaptogenic effects of herbal extracts on isolated brain cells using systems biology. / 15.11.2018 / PubMed / Full text

FOXP1

GATA6 regulates aging of human mesenchymal stem/stromal cells. / 30.11.2020 / PubMed / Full text
Identification of the neurotransmitter profile of AmFoxP expressing neurons in the honeybee brain using double-label in situ hybridization. / 06.11.2018 / PubMed / Full text
Downregulation of FOXP1 correlates with tendon stem/progenitor cells aging. / 26.09.2018 / PubMed / Full text

FYN

An inhibitor role of Nrf2 in the regulation of myocardial senescence and dysfunction after myocardial infarction. / 15.10.2020 / PubMed / Full text
Identification of key genes and transcription factors in aging mesenchymal stem cells by DNA microarray data. / 15.04.2019 / PubMed / Full text
Cell fate regulation by reticulon-4 in human prostate cancers. / 07.2019 / PubMed / Full text

GBA

Reduced sphingolipid hydrolase activities, substrate accumulation and ganglioside decline in Parkinson's disease. / 08.11.2019 / PubMed / Full text
Glycosphingolipid levels and glucocerebrosidase activity are altered in normal aging of the mouse brain. / 07.2018 / PubMed / Full text
GBA mutations in Parkinson disease: earlier death but similar neuropathological features. / 11.2017 / PubMed / Full text

GCLC

Aerobic exercise training partially reverses the impairment of Nrf2 activation in older humans. / 20.11.2020 / PubMed / Full text
Ontogeny and aging of Nrf2 pathway genes in livers of rats. / 15.06.2018 / PubMed / Full text
Proteomic profiling of follicle fluids after superstimulation in one-month-old lambs. / 02.2018 / PubMed / Full text

GEM

The Impact of Geriatric Emergency Management Nurses on the Care of Frail Older Patients in the Emergency Department: a Systematic Review. / 09.2020 / PubMed / Full text
Cytosolic and mitochondrial Ca concentrations in primary hepatocytes change with ageing and in consequence of an mtDNA mutation. / 09.2019 / PubMed / Full text
Understanding of diagnosis and medications among non-English-speaking older patients. / 06.2018 / PubMed / Full text

GPI

Blood factors transfer beneficial effects of exercise on neurogenesis and cognition to the aged brain. / 10.07.2020 / PubMed / Full text
Potential role of exercise-induced glucose-6-phosphate isomerase in skeletal muscle function. / 30.06.2019 / PubMed / Full text
Red Blood Cell Homeostasis and Altered Vesicle Formation in Patients With Paroxysmal Nocturnal Hemoglobinuria. / 2019 / PubMed / Full text

GPX1

Glutathione peroxidase-1 overexpression reduces oxidative stress, and improves pathology and proteome remodeling in the kidneys of old mice. / 06.2020 / PubMed / Full text
Effect of β-D-Mannuronic Acid (M2000) on Oxidative Stress Enzymes' Gene Using Healthy Donor Peripheral Blood Mononuclear Cells for Evaluating the Anti-Aging Property. / 2019 / PubMed / Full text
The impact of preserved Klotho gene expression on antioxidative stress activity in healthy kidney. / 01.08.2018 / PubMed / Full text

GPX4

l-carnitine supplementation during in vitro culture regulates oxidative stress in embryos from bovine aged oocytes. / 02.2020 / PubMed / Full text
Dietary Selenium Supplementation Ameliorates Female Reproductive Efficiency in Aging Mice. / 11.12.2019 / PubMed / Full text
Resveratrol improves in vitro maturation of oocytes in aged mice and humans. / 05.2018 / PubMed / Full text

GSS

Geriatric brain tumor management part I: Meningioma. / 09.2019 / PubMed / Full text
Link between cardiac function and the antioxidative defense mechanism in aged rats. / 11.06.2019 / PubMed / Full text
Towards improving sterile insect technique: Exposure to orange oil compounds increases sexual signalling and longevity in Ceratitis capitata males of the Vienna 8 GSS. / 2017 / PubMed / Full text

GSTM1

The effects of everyday-life exposure to polycyclic aromatic hydrocarbons on biological age indicators. / 03.12.2020 / PubMed / Full text
Carrying the T Allele of the SNP rs574344, an eQTL of GSTM1, Contributes to Longevity in the Han Chinese Population. / 01.2019 / PubMed / Full text
Age-associated changes in GSH S-transferase gene/proteins in livers of rats. / 12.2018 / PubMed / Full text

HDAC4

The posttranslational modification of HDAC4 in cell biology: Mechanisms and potential targets. / 02.2020 / PubMed / Full text
Exercise preconditioning attenuates hind limb unloading-induced gastrocnemius muscle atrophy possibly via the HDAC4/Gadd45 axis in old rats. / 15.07.2019 / PubMed / Full text
Novel anti-aging gene NM_026333 contributes to proton-induced aging via NCX1-pathway. / 12.2018 / PubMed / Full text

HFE

Polyphenol Characterization and Skin-Preserving Properties of Hydroalcoholic Flower Extract from [i]Himantoglossum robertianum[/i] (Orchidaceae). / 14.11.2019 / PubMed / Full text
Hydroalcoholic extract of Spartium junceum L. flowers inhibits growth and melanogenesis in B16-F10 cells by inducing senescence. / 15.07.2018 / PubMed / Full text
Iron-processing genotypes, nutrient intakes, and cadmium levels in the Normative Aging Study: Evidence of sensitive subpopulations in cadmium risk assessment. / 10.2018 / PubMed / Full text

HMGA2

4D Genome Rewiring during Oncogene-Induced and Replicative Senescence. / 07.05.2020 / PubMed / Full text
The protective effects of HMGA2 in the senescence process of bone marrow-derived mesenchymal stromal cells. / 04.2020 / PubMed / Full text
Epigallocatechin-3-gallate and BIX-01294 have different impact on epigenetics and senescence modulation in acute and chronic myeloid leukemia cells. / 05.11.2018 / PubMed / Full text

HSPA8

Influence of Normal Aging on Brain Autophagy: A Complex Scenario. / 2019 / PubMed / Full text
Nitric oxide contributes to protein homeostasis by S-nitrosylations of the chaperone HSPA8 and the ubiquitin ligase UBE2D. / 01.2019 / PubMed / Full text
Cerebrospinal Fluid Concentration of Key Autophagy Protein Lamp2 Changes Little During Normal Aging. / 2018 / PubMed / Full text

ICOS

The Regulatory Status Adopted by Lymph Node Dendritic Cells and T Cells During Healthy Aging Is Maintained During Cancer and May Contribute to Reduced Responses to Immunotherapy. / 2018 / PubMed / Full text
End-stage renal disease, dialysis, kidney transplantation and their impact on CD4 T-cell differentiation. / 10.2018 / PubMed / Full text
Characterization of Blimp-1 function in effector regulatory T cells. / 07.2018 / PubMed / Full text

IGFBP5

Intracellular Heat Shock Protein 70 Deficiency in Pulmonary Fibrosis. / 06.2019 / PubMed / Full text
Blunted satellite cell response is associated with dysregulated IGF-1 expression after exercise with age. / 10.2018 / PubMed / Full text
Material-induced Senescence (MIS): Fluidity Induces Senescent Type Cell Death of Lung Cancer Cells via Insulin-Like Growth Factor Binding Protein 5. / 2017 / PubMed / Full text

IL2

Impact of Aging on the Phenotype of Invariant Natural Killer T Cells in Mouse Thymus. / 2020 / PubMed / Full text
Redox, immune and genetic biomarker system for personalized treatments in colorectal cancer. / 15.02.2019 / PubMed / Full text
Low IL-2 Expressing T Cells in Thalassemia Major Patients: Is It Immune Aging. / 10.2018 / PubMed / Full text

ILK

Age-dependent skeletal muscle transcriptome response to bed rest-induced atrophy. / 01.04.2019 / PubMed / Full text
Hyperphosphatemia Promotes Senescence of Myoblasts by Impairing Autophagy Through Ilk Overexpression, A Possible Mechanism Involved in Sarcopenia. / 10.2018 / PubMed / Full text
Integrin-linked kinase: A new actor in the ageing process? / 15.12.2017 / PubMed / Full text

IPP

Toxic effect of the novel chiral insecticide IPP and its biodegradation intermediate in nematode Caenorhabditis elegans. / 30.11.2018 / PubMed / Full text
The inositol pyrophosphate pathway in health and diseases. / 05.2018 / PubMed / Full text
Integrin-linked kinase: A new actor in the ageing process? / 15.12.2017 / PubMed / Full text

IRF8

IRF8 induces senescence of lung cancer cells to exert its tumor suppressive function. / 12.2019 / PubMed / Full text
Epigenome-wide exploratory study of monozygotic twins suggests differentially methylated regions to associate with hand grip strength. / 10.2019 / PubMed / Full text
Aging impairs both primary and secondary RIG-I signaling for interferon induction in human monocytes. / 12.12.2017 / PubMed / Full text

KIN

The noncanonical small heat shock protein HSP-17 from [i]Caenorhabditis elegans[/i] is a selective protein aggregase. / 06.03.2020 / PubMed / Full text
KIN-4/MAST kinase promotes PTEN-mediated longevity of Caenorhabditis elegans via binding through a PDZ domain. / 06.2019 / PubMed / Full text
Adenine type and diphenyl urea derived cytokinins improve the postharvest performance of [i]Iris germanica[/i] L. cut scapes. / 11.2018 / PubMed / Full text

KLRG1

Are skin senescence and immunosenescence linked within individuals? / 08.2019 / PubMed / Full text
Increased T cell immunosenescence and accelerated maturation phenotypes in older kidney transplant recipients. / 09.2018 / PubMed / Full text
Impact of Aging on the Frequency, Phenotype, and Function of CD161-Expressing T Cells. / 2018 / PubMed / Full text

LAMP1

Differential accumulation of storage bodies with aging defines discrete subsets of microglia in the healthy brain. / 24.06.2020 / PubMed / Full text
A pH probe inhibits senescence in mesenchymal stem cells. / 07.12.2018 / PubMed / Full text
Alterations in Corneal Sensory Nerves During Homeostasis, Aging, and After Injury in Mice Lacking the Heparan Sulfate Proteoglycan Syndecan-1. / 01.10.2017 / PubMed / Full text

LPL

Survival analyses in Holstein cows considering direct disease diagnoses and specific SNP marker effects. / 09.2020 / PubMed / Full text
Influence of common health disorders on the length of productive life and stayability in German Holstein cows. / 01.2020 / PubMed / Full text
GH prevents adipogenic differentiation of mesenchymal stromal stem cells derived from human trabecular bone via canonical Wnt signaling. / 07.2018 / PubMed / Full text

LSS

Surgical results in older patients with lumbar spinal stenosis according to gait speed in relation to the diagnosis for sarcopenia. / 01-04.2020 / PubMed / Full text
Streamlining an existing hip fracture patient pathway in an acute tertiary adult Irish hospital to improve patient experience and outcomes. / 22.12.2019 / PubMed / Full text
Low-dose radiation from A-bombs elongated lifespan and reduced cancer mortality relative to un-irradiated individuals. / 2018 / PubMed / Full text

MAPK1

Purified Vitexin Compound 1 Inhibits UVA-Induced Cellular Senescence in Human Dermal Fibroblasts by Binding Mitogen-Activated Protein Kinase 1. / 2020 / PubMed / Full text
Identification of key genes and transcription factors in aging mesenchymal stem cells by DNA microarray data. / 15.04.2019 / PubMed / Full text
Integrative Analysis of Hippocampus Gene Expression Profiles Identifies Network Alterations in Aging and Alzheimer's Disease. / 2018 / PubMed / Full text

MEF2A

Myocyte enhancer factor 2A delays vascular endothelial cell senescence by activating the PI3K/p-Akt/SIRT1 pathway. / 10.06.2019 / PubMed / Full text
MEF2A alters the proliferation, inflammation-related gene expression profiles and its silencing induces cellular senescence in human coronary endothelial cells. / 18.03.2019 / PubMed / Full text
Identification of key genes and transcription factors in aging mesenchymal stem cells by DNA microarray data. / 15.04.2019 / PubMed / Full text

MGA

Fatigue at baseline is associated with geriatric impairments and represents an adverse prognostic factor in older patients with a hematological malignancy. / 11.2018 / PubMed / Full text
Geriatric assessment in oncology: Moving the concept forward. The 20 years of experience of the Centre Léon Bérard geriatric oncology program. / 11.2018 / PubMed / Full text
Degree of Peripheral Thyroxin Deiodination, Frailty, and Long-Term Survival in Hospitalized Older Patients. / 01.05.2018 / PubMed / Full text

MLKL

Remifentanil preconditioning protects against hypoxia-induced senescence and necroptosis in human cardiac myocytes [i]in vitro[/i]. / 25.06.2020 / PubMed / Full text
Necroptosis increases with age and is reduced by dietary restriction. / 08.2018 / PubMed / Full text
RIPK1-RIPK3-MLKL-dependent necrosis promotes the aging of mouse male reproductive system. / 15.08.2017 / PubMed / Full text

MLN

Age-Dependent Decrease in the Induction of Regulatory T Cells Is Associated With Decreased Expression of RALDH2 in Mesenteric Lymph Node Dendritic Cells. / 2020 / PubMed / Full text
Variability of Spleen and Mesenteric Lymph Node in Control Cynomolgus Monkeys ( Macaca fascicularis) from Nonclinical Safety Studies: A Retrospective Assessment. / 01.2019 / PubMed / Full text
Microanatomical dissection of human intestinal T-cell immunity reveals site-specific changes in gut-associated lymphoid tissues over life. / 03.2019 / PubMed / Full text

MTR

Amide proton transfer-weighted magnetic resonance imaging of human brain aging at 3 Tesla. / 03.2020 / PubMed / Full text
One-carbon metabolism gene polymorphisms are associated with cognitive trajectory among African-American adults. / 12.2019 / PubMed / Full text
Test-retest reliability of myelin imaging in the human spinal cord: Measurement errors versus region- and aging-induced variations. / 2018 / PubMed / Full text

NES

Mini-review: Aging of the neuroendocrine system: Insights from nonhuman primate models. / 08.06.2020 / PubMed / Full text
Age Dependent Hypothalamic and Pituitary Responses to Novel Environment Stress or Lipopolysaccharide in Rats. / 2018 / PubMed / Full text
[Prediction of life expectancy for prostate cancer patients based on the kinetic theory of aging of living systems]. / 2017 / PubMed

NFE2L2

The double-edged sword of MTOR in autophagy deficiency induced-liver injury and tumorigenesis. / 09.2019 / PubMed / Full text
The Association of a Single-Nucleotide Polymorphism in the Nuclear Factor (Erythroid-Derived 2)-Like 2 Gene With Adverse Drug Reactions, Multimorbidity, and Frailty in Older People. / 22.05.2020 / PubMed / Full text
Immunohistochemical localization of Nrf2 in the human cochlea. / 01.12.2018 / PubMed / Full text

NOS1

Prepubertal overexposure to manganese induce precocious puberty through GABA receptor/nitric oxide pathway in immature female rats. / 30.01.2020 / PubMed / Full text
Genetic background, epigenetic factors and dietary interventions which influence human longevity. / 10.2019 / PubMed / Full text
NOS3 Inhibition Confers Post-Ischemic Protection to Young and Aging White Matter Integrity by Conserving Mitochondrial Dynamics and Miro-2 Levels. / 11.07.2018 / PubMed / Full text

NOS3

Application of Oxidative Stress to a Tissue-Engineered Vascular Aging Model Induces Endothelial Cell Senescence and Activation. / 22.05.2020 / PubMed / Full text
Hypertension and longevity: role of genetic polymorphisms in renin-angiotensin-aldosterone system and endothelial nitric oxide synthase. / 05.2019 / PubMed / Full text
NOS3 Inhibition Confers Post-Ischemic Protection to Young and Aging White Matter Integrity by Conserving Mitochondrial Dynamics and Miro-2 Levels. / 11.07.2018 / PubMed / Full text

NRF1

Maternal ageing impairs mitochondrial DNA kinetics during early embryogenesis in mice. / 08.07.2019 / PubMed / Full text
Photobiomodulation and Coenzyme Q Treatments Attenuate Cognitive Impairment Associated With Model of Transient Global Brain Ischemia in Artificially Aged Mice. / 2019 / PubMed / Full text
Androgen receptor polyglutamine expansion drives age-dependent quality control defects and muscle dysfunction. / 01.08.2018 / PubMed / Full text

OGT

ELT-2 promotes O-GlcNAc transferase OGT-1 expression to modulate Caenorhabditis elegans lifespan. / 06.07.2020 / PubMed / Full text
Neuronal O-GlcNAcylation Improves Cognitive Function in the Aged Mouse Brain. / 21.10.2019 / PubMed / Full text
Schwann cell O-GlcNAcylation promotes peripheral nerve remyelination via attenuation of the AP-1 transcription factor JUN. / 31.07.2018 / PubMed / Full text

OXTR

Association of oxytocin levels and oxytocin receptor gene polymorphism (rs2254298) with cardiovascular risk factors in Brazilian elderly from Primary Health Care. / 09-10.2019 / PubMed / Full text
Impact of housing conditions on social behavior, neuroimmune markers, and oxytocin receptor expression in aged male and female Fischer 344 rats. / 08.2019 / PubMed / Full text
Associations between oxytocin receptor gene (OXTR) methylation, plasma oxytocin, and attachment across adulthood. / 02.2019 / PubMed / Full text

PFAS

Associations between serum concentrations of perfluoroalkyl substances and DNA methylation in women exposed through drinking water: A pilot study in Ronneby, Sweden. / 12.2020 / PubMed / Full text
Perfluorinated alkyl substances impede growth, reproduction, lipid metabolism and lifespan in Daphnia magna. / 01.10.2020 / PubMed / Full text
The effect of weathering on per- and polyfluoroalkyl substances (PFASs) from durable water repellent (DWR) clothing. / 06.2020 / PubMed / Full text

PI3

Pulmonary Diseases and Ageing. / 2019 / PubMed / Full text
CD57 identifies T cells with functional senescence before terminal differentiation and relative telomere shortening in patients with activated PI3 kinase delta syndrome. / 11.2018 / PubMed / Full text
Maternal diabetes up-regulates NOX2 and enhances myocardial ischaemia/reperfusion injury in adult offspring. / 04.2018 / PubMed / Full text

PLAU

Identification of key genes and transcription factors in aging mesenchymal stem cells by DNA microarray data. / 15.04.2019 / PubMed / Full text
Towards frailty biomarkers: Candidates from genes and pathways regulated in aging and age-related diseases. / 11.2018 / PubMed / Full text
G protein-coupled receptor kinase 4-induced cellular senescence and its senescence-associated gene expression profiling. / 15.11.2017 / PubMed / Full text

PNP

Temporal Discrimination Thresholds and Proprioceptive Performance: Impact of Age and Nerve Conduction. / 2019 / PubMed / Full text
Polyneuropathy in Severely Obese Women Without Diabetes: Prevalence and Associated Factors. / 03.2019 / PubMed / Full text
Electrophysiological evidence for preserved primacy of lexical prediction in aging. / 08.2018 / PubMed / Full text

POR

The Ventricular System Enlarges Abnormally in the Seventies, Earlier in Men, and First in the Frontal Horn: A Study Based on More Than 3,000 Scans. / 2019 / PubMed / Full text
Clinical findings associated with development of postoperative reflux and short-term survival after small intestinal surgery in geriatric and mature nongeriatric horses. / 07.2019 / PubMed / Full text
Effect of Age and Allele Variants of CYP3A5, CYP3A4, and POR Genes on the Pharmacokinetics of Cyclosporin A in Pediatric Renal Transplant Recipients From Serbia. / 12.2017 / PubMed / Full text

PRDX1

Active vitamin D supplementation alleviates initiation and progression of nonalcoholic fatty liver disease by repressing the p53 pathway. / 15.01.2020 / PubMed / Full text
PRDX1 and MTH1 cooperate to prevent ROS-mediated inhibition of telomerase. / 01.05.2018 / PubMed / Full text
Proteomic profiling of follicle fluids after superstimulation in one-month-old lambs. / 02.2018 / PubMed / Full text

PRDX3

Proteomic analyses reveal that ginsenoside Rg3([i]S[/i]) partially reverses cellular senescence in human dermal fibroblasts by inducing peroxiredoxin. / 01.2020 / PubMed / Full text
Late life maintenance and enhancement of functional exercise capacity in low and high responding rats after low intensity treadmill training. / 01.10.2019 / PubMed / Full text
The impact of preserved Klotho gene expression on antioxidative stress activity in healthy kidney. / 01.08.2018 / PubMed / Full text

PVR

Age estimation based on the volume change in the maxillary premolar crown using micro CT. / 03.2019 / PubMed / Full text
Effect of age on the presence of comet tails at high altitude. / 01.2019 / PubMed / Full text
Natural history of post-void residual urine volume over 5 years in community-dwelling older men: The Concord Health and Ageing in Men Project. / 03.2018 / PubMed / Full text

RHEB

The Rheb-TORC1 signaling axis functions as a developmental checkpoint. / 02.03.2020 / PubMed / Full text
Long-lived rodents reveal signatures of positive selection in genes associated with lifespan. / 03.2018 / PubMed / Full text
CGEF-1 regulates mTORC1 signaling during adult longevity and stress response in [i]C. elegans[/i]. / 09.02.2018 / PubMed / Full text

RHO

Conditional reprogramming: next generation cell culture. / 08.2020 / PubMed / Full text
SARS-CoV-2 receptor ACE2 and TMPRSS2 are primarily expressed in bronchial transient secretory cells. / 18.05.2020 / PubMed / Full text
Redox Signaling of NADPH Oxidases Regulates Oxidative Stress Responses, Immunity and Aging. / 28.09.2018 / PubMed / Full text

ROCK1

Disruption of both ROCK1 and ROCK2 genes in cardiomyocytes promotes autophagy and reduces cardiac fibrosis during aging. / 06.2019 / PubMed / Full text
Sonic hedgehog regulation of cavernous nerve regeneration and neurite formation in aged pelvic plexus. / 02.2019 / PubMed / Full text
Vascular Smooth Muscle Contractile Function Declines With Age in Skeletal Muscle Feed Arteries. / 2018 / PubMed / Full text

RUNX2

Collaboration of MYC and RUNX2 in lymphoma simulates T-cell receptor signaling and attenuates p53 pathway activity. / 10.2019 / PubMed / Full text
Chondrocyte-Specific RUNX2 Overexpression Accelerates Post-traumatic Osteoarthritis Progression in Adult Mice. / 09.2019 / PubMed / Full text
microRNA-31 inhibition partially ameliorates the deficiency of bone marrow stromal cells from cleidocranial dysplasia. / 06.2019 / PubMed / Full text

S100A8

S100A8, which increases with age, induces cellular senescence-like changes in bovine oviduct epithelial cells. / 09.2019 / PubMed / Full text
Fetal articular cartilage regeneration versus adult fibrocartilaginous repair: secretome proteomics unravels molecular mechanisms in an ovine model. / 06.07.2018 / PubMed / Full text
Lung cellular senescence is independent of aging in a mouse model of COPD/emphysema. / 13.06.2018 / PubMed / Full text

SCT

Short-Term Training and Detraining Effects of Supervised vs. Unsupervised Resistance Exercise in Aging Adults. / 10.2019 / PubMed / Full text
High-intensity interval training improves acute plasma volume responses to exercise that is age dependent. / 02.2018 / PubMed / Full text
Communication technology adoption among older adult veterans: the interplay of social and cognitive factors. / 12.2018 / PubMed / Full text

SDC1

Olmesartan alleviates bleomycin-mediated vascular smooth muscle cell senescence via the miR-665/SDC1 axis. / 2020 / PubMed / Full text
Sulfated syndecan 1 is critical to preventing cellular senescence by modulating fibroblast growth factor receptor endocytosis. / 08.2020 / PubMed / Full text
Alterations in Corneal Sensory Nerves During Homeostasis, Aging, and After Injury in Mice Lacking the Heparan Sulfate Proteoglycan Syndecan-1. / 01.10.2017 / PubMed / Full text

SERPINE1

Elevated circulating HtrA4 in preeclampsia may alter endothelial expression of senescence genes. / 15.01.2020 / PubMed / Full text
Human iPSC-derived MSCs (iMSCs) from aged individuals acquire a rejuvenation signature. / 18.03.2019 / PubMed / Full text
A null mutation in [i]SERPINE1[/i] protects against biological aging in humans. / 11.2017 / PubMed / Full text

SHH

Recent advances in SHH medulloblastoma progression: tumor suppressor mechanisms and the tumor microenvironment. / 2019 / PubMed / Full text
An Endogenous Anti-aging Factor, Sonic Hedgehog, Suppresses Endometrial Stem Cell Aging through SERPINB2. / 03.07.2019 / PubMed / Full text
Sonic hedgehog regulation of cavernous nerve regeneration and neurite formation in aged pelvic plexus. / 02.2019 / PubMed / Full text

SIRT5

Lysine malonylation and propionylation are prevalent in human lens proteins. / 01.2020 / PubMed / Full text
Analysis of Polymorphisms in 59 Potential Candidate Genes for Association With Human Longevity. / 08.10.2018 / PubMed / Full text
Expression of Sirtuins in the Retinal Neurons of Mice, Rats, and Humans. / 2017 / PubMed / Full text

SLC6A4

The Psilocybin-Telomere Hypothesis: An empirically falsifiable prediction concerning the beneficial neuropsychopharmacological effects of psilocybin on genetic aging. / 01.2020 / PubMed / Full text
Epigenetics-by-sex interaction for somatization conferred by methylation at the promoter region of SLC6A4 gene. / 08.03.2019 / PubMed / Full text
Proteomics and metabolomics identify molecular mechanisms of aging potentially predisposing for chronic lymphocytic leukemia. / 02.2018 / PubMed / Full text

SNAI1

MicroRNA-338-5p plays a tumor suppressor role in glioma through inhibition of the MAPK-signaling pathway by binding to FOXD1. / 12.2018 / PubMed / Full text
O-GlcNAcylation is required for mutant KRAS-induced lung tumorigenesis. / 01.11.2018 / PubMed / Full text
Upregulation of lactate-inducible snail protein suppresses oncogene-mediated senescence through p16 inactivation. / 26.02.2018 / PubMed / Full text

SNAP25

The Biological Foundations of Sarcopenia: Established and Promising Markers. / 2019 / PubMed / Full text
Frontotemporal dysregulation of the SNARE protein interactome is associated with faster cognitive decline in old age. / 06.2018 / PubMed / Full text
NUPR1 maintains autolysosomal efflux by activating SNAP25 transcription in cancer cells. / 2018 / PubMed / Full text

SOCS3

Congenital Hypothyroidism is Associated With Impairment of the Leptin Signaling Pathway in the Hypothalamus in Male Wistar Animals in Adult Life. / 05.2019 / PubMed / Full text
Deletion of suppressor of cytokine signaling 3 (SOCS3) in muscle stem cells does not alter muscle regeneration in mice after injury. / 2019 / PubMed / Full text
Age-related remodeling of the JAK/STAT/SOCS signaling pathway and associated myocardial changes: From histological to molecular level. / 11.2017 / PubMed / Full text

SPRY1

Sprouty1 Prevents Cellular Senescence Maintaining Proliferation and Differentiation Capacity of Human Adipose Stem/Progenitor Cells. / 13.11.2020 / PubMed / Full text
Mechanism of SPRY1 methylation regulating natural aging of skin epidermal cells. / 05.2020 / PubMed / Full text
MicroRNA-21 promotes glioma cell proliferation and inhibits senescence and apoptosis by targeting SPRY1 via the PTEN/PI3K/AKT signaling pathway. / 05.2018 / PubMed / Full text

SRC

Metabolic characteristics of CD8 T cell subsets in young and aged individuals are not predictive of functionality. / 05.06.2020 / PubMed / Full text
Overexpression of steroid receptor coactivators alleviates hyperglycemia-induced endothelial cell injury in rats through activating the PI3K/Akt pathway. / 05.2019 / PubMed / Full text
Integrative Analysis of Hippocampus Gene Expression Profiles Identifies Network Alterations in Aging and Alzheimer's Disease. / 2018 / PubMed / Full text

SYK

miR-25-3p promotes endothelial cell angiogenesis in aging mice via TULA-2/SYK/VEGFR-2 downregulation. / 17.11.2020 / PubMed / Full text
Identification of SYK inhibitor, R406 as a novel senolytic agent. / 07.05.2020 / PubMed / Full text
Integrative Analysis of Hippocampus Gene Expression Profiles Identifies Network Alterations in Aging and Alzheimer's Disease. / 2018 / PubMed / Full text

TET1

Age-related Changes in the Global DNA Methylation Profile of Oligodendrocyte Progenitor Cells Derived from Rat Spinal Cords. / 02.2019 / PubMed / Full text
Epigenetic Co-Deregulation of EZH2/TET1 is a Senescence-Countering, Actionable Vulnerability in Triple-Negative Breast Cancer. / 2019 / PubMed / Full text
DNA Hydroxymethylation Levels Are Altered in Blood Cells From Down Syndrome Persons Enrolled in the MARK-AGE Project. / 09.05.2018 / PubMed / Full text

TLR1

Effects of aging and lifelong aerobic exercise on expression of innate immune components in human skeletal muscle. / 01.12.2020 / PubMed / Full text
Association of TLR gene variants in a Czech Red Pied cattle population with reproductive traits. / 02.2020 / PubMed / Full text
Decreased NLRP3 inflammasome expression in aged lung may contribute to increased susceptibility to secondary Streptococcus pneumoniae infection. / 05.2018 / PubMed / Full text

TMEM106B

Genetics of Gene Expression in the Aging Human Brain Reveal TDP-43 Proteinopathy Pathophysiology. / 05.08.2020 / PubMed / Full text
TMEM106B, a risk factor for FTLD and aging, has an intrinsically disordered cytoplasmic domain. / 2018 / PubMed / Full text
TMEM106B haplotypes have distinct gene expression patterns in aged brain. / 03.07.2018 / PubMed / Full text

TNC

Effects of Tenascin C on the Integrity of Extracellular Matrix and Skin Aging. / 18.11.2020 / PubMed / Full text
Tenascin-C expression controls the maturation of articular cartilage in mice. / 17.02.2020 / PubMed / Full text
Effects of hydrothermal aging, thermal cycling, and water storage on the mechanical properties of a machinable resin-based composite containing nano-zirconia fillers. / 02.2020 / PubMed / Full text

TRA

MYC Releases Early Reprogrammed Human Cells from Proliferation Pause via Retinoblastoma Protein Inhibition. / 10.04.2018 / PubMed / Full text
Sex-specific regulation of aging in Caenorhabditis elegans. / 06.2018 / PubMed / Full text
Age-Associated Decline in Thymic B Cell Expression of Aire and Aire-Dependent Self-Antigens. / 30.01.2018 / PubMed / Full text

TRAF3

TRAF3, a Target of MicroRNA-363-3p, Suppresses Senescence and Regulates the Balance Between Osteoblastic and Adipocytic Differentiation of Rat Bone Marrow-Derived Mesenchymal Stem Cells. / 01.06.2020 / PubMed / Full text
TGFβ-induced degradation of TRAF3 in mesenchymal progenitor cells causes age-related osteoporosis. / 26.06.2019 / PubMed / Full text
Aging impairs both primary and secondary RIG-I signaling for interferon induction in human monocytes. / 12.12.2017 / PubMed / Full text

TRIM59

DNA methylation of the ELOVL2, FHL2, KLF14, C1orf132/MIR29B2C, and TRIM59 genes for age prediction from blood, saliva, and buccal swab samples. / 01.2019 / PubMed / Full text
Proof of concept study of age-dependent DNA methylation markers across different tissues by massive parallel sequencing. / 09.2018 / PubMed / Full text
Chronological age prediction based on DNA methylation: Massive parallel sequencing and random forest regression. / 11.2017 / PubMed / Full text

TRPV1

Reduced bladder responses to capsaicin and GSK-1016790A in retired-breeder female rats with diminished volume sensitivity. / 01.11.2018 / PubMed / Full text
Expression of CGRP neurotransmitter and vascular genesis marker mRNA is age-dependent in superior cervical ganglia of senescence-accelerated prone mice. / 18.01.2018 / PubMed / Full text
A comparative study on the therapeutic effect of TRPV1, TRPA1, and TRPM8 agonists on swallowing dysfunction associated with aging and neurological diseases. / 02.2018 / PubMed / Full text

TSC1

mTORC1 underlies age-related muscle fiber damage and loss by inducing oxidative stress and catabolism. / 06.2019 / PubMed / Full text
FTO is involved in Alzheimer's disease by targeting TSC1-mTOR-Tau signaling. / 25.03.2018 / PubMed / Full text
Postnatal reduction of tuberous sclerosis complex 1 expression in astrocytes and neurons causes seizures in an age-dependent manner. / 12.2017 / PubMed / Full text

VDAC1

Low abundance of NDUFV2 and NDUFS4 subunits of the hydrophilic complex I domain and VDAC1 predicts mammalian longevity. / 07.2020 / PubMed / Full text
Changes in the expression of oxidative phosphorylation complexes in the aging intestinal mucosa. / 01.07.2020 / PubMed / Full text
Cytosolic and mitochondrial Ca concentrations in primary hepatocytes change with ageing and in consequence of an mtDNA mutation. / 09.2019 / PubMed / Full text

VHL

Hypoxic response regulators RHY-1 and EGL-9/PHD promote longevity through a VHL-1-independent transcriptional response. / 12.2020 / PubMed / Full text
The Energy Maintenance Theory of Aging: Maintaining Energy Metabolism to Allow Longevity. / 08.2018 / PubMed / Full text
Shorter telomere length increases age-related tumor risks in von Hippel-Lindau disease patients. / 09.2017 / PubMed / Full text

VIM

Establishment and characterization of a fibroblast cell line from postmortem skin of an adult Chinese muntjac (Muntiacus reevesi). / 02.2020 / PubMed / Full text
The effect of test modality on dynamic exercise biomarkers in children, adolescents, and young adults. / 07.2019 / PubMed / Full text
Centenarians Overexpress Pluripotency-Related Genes. / 16.08.2019 / PubMed / Full text

VWF

Von Willebrand disease in the elderly: clinical perspectives. / 2018 / PubMed / Full text
Comorbidities associated with higher von Willebrand factor (VWF) levels may explain the age-related increase of VWF in von Willebrand disease. / 07.2018 / PubMed / Full text
The Association of Aging With Von Willebrand Factor Levels and Bleeding Risk in Type 1 Von Willebrand Disease. / 04.2018 / PubMed / Full text

WNT1

Plasma proteomic profile of age, health span, and all-cause mortality in older adults. / 11.2020 / PubMed / Full text
Aging Disrupts Muscle Stem Cell Function by Impairing Matricellular WISP1 Secretion from Fibro-Adipogenic Progenitors. / 07.03.2019 / PubMed / Full text
Wnt1 is an Lrp5-independent bone-anabolic Wnt ligand. / 07.11.2018 / PubMed / Full text

WNT3A

Chronic WNT/β-catenin signaling induces cellular senescence in lung epithelial cells. / 06.2020 / PubMed / Full text
WNT3A accelerates delayed alveolar bone repair in ovariectomized mice. / 09.2019 / PubMed / Full text
WNT-activated bone grafts repair osteonecrotic lesions in aged animals. / 27.10.2017 / PubMed / Full text

XIAP

Directed elimination of senescent cells attenuates development of osteoarthritis by inhibition of c-IAP and XIAP. / 01.10.2019 / PubMed / Full text
Modulated electro-hyperthermia induced p53 driven apoptosis and cell cycle arrest additively support doxorubicin chemotherapy of colorectal cancer in vitro. / 08.2019 / PubMed / Full text
Protective effect of xanthohumol against age-related brain damage. / 11.2017 / PubMed / Full text

XPA

Analysis of somatic mutations identifies signs of selection during in vitro aging of primary dermal fibroblasts. / 12.2019 / PubMed / Full text
Proteomics and metabolomics identify molecular mechanisms of aging potentially predisposing for chronic lymphocytic leukemia. / 02.2018 / PubMed / Full text
Systematic analysis of DNA crosslink repair pathways during development and aging in Caenorhabditis elegans. / 19.09.2017 / PubMed / Full text