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...from hepatitis C virus infection-associated senescence via ΔNp63-miR-181a-Sirt1 pathway. ...umber of Foxp3 effector T (T ) cells upon manipulating the ΔNp63-miR-181a-Sirt1 pathway. In conclusion, these findings provide novel mechanistic insights i ...

.... IGF-I levels were lower in RasGrf1(-/-) than in controls. Furthermore, [[SIRT1]] expression was increased in RasGrf1(-/-) animals. Consistent with this, t ...

.... In addition, 64 SNPs loci distributed in 13 candidate genes [[FOXO3]], [[SIRT1]], [[TOMM40]], [[APOE]], [[PICALM]], [[COMT]], [[CETP]], [[CLU]], [[CR1]], ...

...[[DLC1]] promoted senescence through FoxO3a/NF-κB signaling mediated by [[SIRT1]] after resveratrol treatment. Finally, resveratrol increased ROS productio * SIRT1 ...

...levels) in parallel to decreased H S production and rejuvenation (LC3 and SIRT1)-related gene expression. In addition, [[CBS]] gene KD in ASC52telo cells r ...

...with antibodies for p21, p16, and β-galactosidase (senescence); for LC3, [[SIRT1]], [[MAP1S]], and pAMKα (autophagy); and for LDH and GLUT1 (metabolism). E ...

* SIRT1 |title=Negative reciprocal regulation between Sirt1 and Per2 modulates the circadian clock and aging. ...

...s, Cyclin A2, Cyclin D1, [[CDK2]], [[CDK6]], [[ETS1]], [[NBN]], [[RB1]], [[SIRT1]], were down-regulated. The increase in cyclin-dependent kinase inhibitors ...

...abolism. EGCG significantly increased the protein expression of [[FOXO1]], Sirt1, [[CAT]], [[FABP1]], [[GSTA2]], [[ACSL1]] and [[CPT2]] but significantly de ...

...es treated with the NAD [[SIRT1]] cofactor, than in cells treated with a [[SIRT1]] inhibitor. Inhibition of importin β by importazole maintained [[SOX9]] i * SIRT1 ...

...myocardial contractile function with adaptive cardiac remodeling: role of Sirt1-mediated autophagy regulation. ...ctile dysfunction and loss of mitophagy were improved by rapamycin and the Sirt1 activator SRT1720. Activation of Akt using insulin or Parkin deficiency pre ...

...ed galactosidase, beta 1; SASP: senescence-associated secretory phenotype; SIRT1: sirtuin 1; Spautin 1: specific and potent autophagy inhibitor 1; [[SQSTM1] ...ated changes in cathepsin D levels in humans and the association between [[SIRT1]] and eNOS. ...

...rotein kinases and other factors, such as mTOR, [[ULK1]], [[HDAC5]], and [[SIRT1]]. Given that AMPK and HIF activation can enhance not only healthspan and l ...el of NAD( ). NAD( ) is a substrate for nuclear sirtuins, especially for [[SIRT1]] and [[SIRT6]], which deacetylate histones and transcription factors, e.g. ...

...the 4 potential candidate genes [[ETV1]], [[ONECUT1]], [[MACROD2]], and [[SIRT1]], which directly (via disease resistance mechanisms) or indirectly (via mi ...

|title=[[SIRT1]] - a new mammalian substrate of nuclear autophagy. ...er substrate of nuclear autophagy and suggests a new strategy to promote [[SIRT1]]-mediated health benefits by suppressing its autophagic degradation. ...

|title=Loss-of-[[SIRT1]] function during vascular ageing: hyperphosphorylation mediated by cyclin- ...[[SIRT1]] function during vascular ageing. Thus, by inhibiting [[CDK5]], [[SIRT1]] function can be improved, in turn preventing the development of atheroscl ...

...se receiving the LP diet. Furthermore, [[HP]] feeding increased relative [[SIRT1]] mRNA levels. Additional mechanistic cell culture experiments were perform ...

...by the [[CCAR2]] ortholog, CCAR-1. This negative regulation requires the [[SIRT1]] homolog SIR-2.1. In addition, knockdown of CCAR-1 via ccar-1 RNAi works t ...Fs and Hsps in skeletal muscle. We studied the protein levels of sirtuins (SIRT1, [[SIRT2]], [[SIRT3]], [[SIRT4]], [[SIRT5]], [[SIRT6]] and SIRT7), [[HSF1]] ...

...at melatonin may help the hippocampal neuronal homeostasis by increasing [[SIRT1]], [[FOXO1]] and melatonin receptors expression while decreasing [[DKK1]] e ...

...and BAT weight). In addition, mitochondrial biogenesis proteins (PGC-1α, [[SIRT1]], and pAMPK) and respiratory chain activity (complexes I, II/III, III, and ...