FGA
Fibrinogen alpha chain precursor [Contains: Fibrinopeptide A; Fibrinogen alpha chain]
Publications[править]
Aging with physical disability disrupts one's ability to achieve valued goals due to changes in symptoms and function. It is unclear how to cope optimally in this context. This study examined whether two possible strategies-tenacious goal pursuit (TGP) and flexible goal adjustment (FGA)-were associated with reduced pain interference and depressive symptoms and greater well-being, and protected against pain intensity, and FGA was more protective with increasing age and worse physical function. Middle-aged adults with muscular dystrophy, multiple sclerosis, post-polio syndrome, or spinal cord injury ([i]N[/i] = 874; [i]M[/i] = 58.3 years, range = 46-68; [i]M[/i] = 26.2 years, range = 2-67) completed two questionnaires, a year apart. TGP and FGA use was associated with greater well-being. FGA use predicted decreased depressive symptoms. Concurrent use of both predicted decreased pain interference. Adults with disability employ a variety of goal management strategies. Findings support TGP and FGA as potential intervention targets for healthy aging with disabilities.
MeSH Terms
- Adaptation, Psychological
- Aged
- Aging
- Depression
- Disabled Persons
- Female
- Goals
- Humans
- Male
- Middle Aged
- Multiple Sclerosis
- Muscular Dystrophies
- Pain
- Postpoliomyelitis Syndrome
- Spinal Cord Injuries
Keywords
- aging
- disability
- goal management
- pain
- psychological adaptation
We aimed to examine the roles of tenacious goal pursuit (TGP) and flexible goal adjustment (FGA), mediated by positive self-perceptions of aging (PSA), in Chinese older couples' life satisfaction. Using a cross-sectional design, 245 Chinese older couples (age range: 55-93 years) completed measures of TGP, FGA, PSA, and life satisfaction. The results showed that (a) spousal interrelations existed for TGP and FGA; (b) TGP and FGA had significant actor effects on life satisfaction, with FGA having a stronger effect; (c) although the partner effect of FGA did not differ between husbands and wives, husbands' TGP was positively associated with wives' life satisfaction, but not vice versa; and (d) PSA mediated the effects of TGP and FGA on life satisfaction at the actor and partner levels. These results have implications for developing couple-based interventions to enhance successful aging, with a focus on promoting both partners' accommodative coping and positive age beliefs.
Keywords
- flexible goal adjustment
- life satisfaction
- older couples
- self-perceptions of aging
- tenacious goal pursuit
As people age, functional losses may limit the potential to get outside the home and participate in desired activities and community life. Coping with age-related losses has been reported to be important for psychological well-being. Hitherto is not known whether active use of coping strategies also helps maintain out-of-home mobility. We investigated how two coping strategies, tenacious goal pursuit (TGP; persistency in reaching one's goals) and flexible goal adjustment (FGA; adjusting one's goals to changed circumstances), are associated with life-space mobility and perceived autonomy in participation outdoors among community-dwelling older people. Participants (n = 186) were aged 79-93 years. TGP and FGA were self-reported using separate scales. Perceived autonomy in participation was assessed with the Impact on Participation and Autonomy Outdoors-subscale, and life-space mobility with the Life-Space Assessment. Two-step cluster analysis was used to create data-driven coping profiles of TGP and FGA. General linear model analyses showed that the profile including highly tenacious and flexible older people had the highest life-space mobility and perceived autonomy outdoors, whereas the profile including people with low TGP and low FGA showed the lowest scores. Depressive symptoms attenuated the associations. Active use of both TGP and FGA is favorable for out-of-home mobility and enables more active participation in society in later life.
MeSH Terms
- Adaptation, Psychological
- Aged
- Aged, 80 and over
- Aging
- Cluster Analysis
- Depression
- Female
- Goals
- Humans
- Independent Living
- Male
- Mobility Limitation
- Surveys and Questionnaires
Keywords
- Aging
- Autonomy
- Coping
- Mobility
- Participation
Sensory impaired older adults may be particularly dependent on coping strategies such as assimilation (or tenacious goal pursuit [TGP]) and accommodation (or flexible goal adjustment [[[FGA]]]) to secure high levels of well-being. We investigated if late-life changes in these coping strategies and prospective associations of TGP and FGA with affective well-being vary according to sensory impairment status. Our study sample consisted of 387 adults aged 72-95 years ([i]M[/i] = 82.50 years, SD =4.71 years) who were either visually impaired (VI; [i]n[/i] = 121), hearing impaired (HI; [i]n[/i] = 116), or sensory unimpaired (UI; [i]n[/i] = 150). One hundred sixty-eight individuals were reassessed after approximately 4 years. Both VI and HI revealed a decrease in TGP, whereas TGP remained stable in UI. For FGA, a significant increase in HI was observed, whereas a significant decline emerged in UI. Controlling for age, gender, and cognitive abilities, higher TGP at baseline was significantly associated with higher negative affect 4 years later in VI. Moreover, the positive association between baseline FGA and subsequent positive affect was stronger in HI than in UI older adults. Our findings suggest that older adults with sensory impairments reveal trajectories of assimilative and accommodative coping and associations of TGP and FGA with affective well-being that are different from sensory unimpaired individuals.
MeSH Terms
- Adaptation, Psychological
- Aged
- Aged, 80 and over
- Aging
- Case-Control Studies
- Disease Progression
- Female
- Goals
- Humans
- Longitudinal Studies
- Male
- Persons With Hearing Impairments
- Visually Impaired Persons
Keywords
- Tenacious goal pursuit
- affect
- flexible goal adjustment
- hearing impairment
- vision impairment
Previous studies have examined the independent roles of positive age stereotypes (PAS) and negative age stereotypes (NAS) in successful aging. This study aimed to examine the joint effect of PAS and NAS on the well-being of Chinese older adults, and to further examine whether this effect was moderated by flexible goal adjustment (FGA). Using a cross-sectional design, 279 Chinese older adults (age range 60‒97 years) completed measures related to age stereotypes, FGA, and well-being. The results showed that PAS interacted with NAS to predict well-being. In addition, the joint effect of PAS and NAS was moderated by FGA. Specially, for older adults with low FGA, NAS weakened the positive association between PAS and well-being; whereas, for older adults with high FGA, NAS could not influence the association between PAS and well-being. Tailored interventions to modify aging perceptions and to enhance coping flexibility competence might be helpful for promoting the well-being of older adults.
MeSH Terms
- Aged
- Aged, 80 and over
- Ageism
- Aging
- China
- Cross-Sectional Studies
- Female
- Goals
- Health Knowledge, Attitudes, Practice
- Humans
- Male
- Middle Aged
- Personal Satisfaction
- Social Adjustment
- Stereotyping
Keywords
- Age stereotypes
- flexible goal adjustment
- older adults
- well-being
Advancing age is associated with cardiovascular disease, diabetes mellitus and cancer, and shows significant inter-individual variability. To identify ageing-related biomarkers we performed a proteomic analysis on 1890 Chinese Han individuals, 1136 males and 754 females, aged 18 to 82 years, using weak cation exchange magnetic bead based MALDI-TOF-MS analysis. The study identified 44 peptides which varied in concentration in different age groups. In particular, apolipoprotein A-I (ApoA1) concentration gradually increased between 18 to 50 years of age, the levels of fibrinogen alpha (FGA) decreased over the same age span, while albumin (ALB) was significantly degraded in middle-aged individuals. In addition, the plasma peptide profiles of FGA and four other unidentified proteins were found to be gender-dependent. Plasma proteins such as FGA, ALB and ApoA1 are significantly correlated with age in the Chinese Han population and could be employed as indicative ageing-related biomarkers.
MeSH Terms
- Adolescent
- Adult
- Aged
- Aged, 80 and over
- Aging
- Apolipoprotein A-I
- Biomarkers
- Female
- Fibrinogen
- Humans
- Male
- Middle Aged
- Peptides
- Serum Albumin
- Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization
- Transcriptome