ALB
Albumin precursor [GIG20] [GIG42] [PRO0903] [PRO1708] [PRO2044] [PRO2619] [PRO2675] [UNQ696/PRO1341]
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Animals tend to increase in body weight and body condition score (BCS) with aging. Serum diagnostic markers related to energy metabolism may show changes even in healthy cats with aging. Seventy domestic cats were recruited for this study. Based upon the modified AAFP-AAHA Feline Life Stage Guidelines, animals were divided into six groups: Junior (7 months-2 years), Prime (3 -6 years), Mature (7-10 years), Senior (11-14 years), Geriatric-obese (15 years ≤) and Geriatric-thin (15 years ≤). Their body condition scores (BCS) ranged from 3/9 to 9/9. Changes in metabolites, inflammatory markers, hormone concentrations and enzyme activities related to energy metabolism were investigated in serum of 70 domestic cats of various ages. Serum glucose (GLU) concentrations in the Mature, Senior, and Geriatric-obese groups were significantly higher than those in the Junior group. Serum amyloid A (SAA) concentrations in the Geriatric-thin group were significantly increased compared with the Junior group. SAA concentrations in the Geriatric-obese group tended to increase although there were no statistically significant differences. In the Mature, Senior, Geriatric-obese and Geriatric-thin groups, malate dehydrogenase/lactate dehydrogenase (M/L) ratio, an energy metabolic indicator, tended to decrease compared with the Junior group. In the Senior group, triglyceride (TG) concentrations were significantly increased compared with the Junior group. In the Geriatric-obese and Geriatric-thin groups, blood urea nitrogen (BUN) concentrations were significantly increased compared with the Junior group. In the Geriatric-obese group, albumin (ALB) concentrations were decreased compared with the Junior group. Aged domestic cats tend to increase in body weight and BCS. In addition, serum GLU, TG, SAA, and BUN concentrations increased and serum ALB concentrations and M/L ratio decreased. These diagnostic markers may be useful to detect small changes related to energy metabolism with aging that may cause obesity with light inflammation in healthy cats.
Keywords
- M/L ratio
- SAA
- aging
- domestic cats
- obesity
Because of the presence of sperm storage tubules (SSTs) in the utero-vaginal junction (UVJ) in the oviduct, once ejaculated sperm enter the female reproductive tract, they can survive for a prolonged period in domestic birds; however, the specific mechanisms involved in sperm maintenance within the SST remain to be elucidated. In this study, we showed that transferrin (TF) and albumin (ALB) are expressed in SSTs. When UVJ extracts were subjected to size-exclusion column chromatography, we obtained fractions that extend sperm longevity [i]in vitro[/i]. LC-MS/MS analysis of the two major proteins in the fractions identified these proteins as TF and ALB. Immunohistochemical analysis using specific antisera against TF and ALB indicated that both proteins were localized not only in the SSTs, but also in the surface epithelium of the UVJ. When the ejaculated sperm were incubated with either purified TF or ALB, sperm viability increased after 24 h. These results indicated that oviductal TF and ALB are involved in the process of sperm storage in SSTs and may open a new approach for technological improvement to prolong sperm longevity [i]in vitro[/i].
Keywords
- Japanese quail
- albumin
- sperm longevity
- sperm storage tubules
- transferrin
Physiological characteristics, such as blood chemistry values, are valuable for evaluating the health of the animals. To our knowledge, these values have never been reported for the free-ranging Asiatic black bear ( Ursus thibetanus; ABB). Thus, 28 blood chemistry values from 50 free-ranging ABBs captured in Jirisan National Park, Republic of Korea, from 2005 to 2016 were evaluated. The aim of this study was to establish blood chemistry reference values for the free-ranging ABBs during both the hibernating and nonhibernating seasons. During hibernation, mean values of creatinine (CRE), total cholesterol, total protein (TP), albumin (ALB), triglycerides, and magnesium were significantly higher than those during nonhibernation; however, mean values of blood urea nitrogen, urea nitrogen to creatinine (U/C) ratio, inorganic phosphorous (IP), aspartate aminotransferase, alanine aminotransferase, gamma-glutamyl transferase, lactate dehydrogenase (LDH), high-density lipoprotein cholesterol, and alkaline phosphatase (ALP) were significantly lower. Age differences (young vs. adult) were found in IP, LDH, TP, and ALB values during hibernation and in the U/C ratio, calcium, IP, ALP, creatine kinase myocardial band, CRE, total bilirubin, and uric acid values during nonhibernation. However, there were no sex differences (male vs. female).
MeSH Terms
- Aging
- Ammonia
- Animals
- Bilirubin
- Blood Glucose
- Blood Urea Nitrogen
- Cholesterol
- Creatine
- Female
- Hibernation
- Liver
- Male
- Minerals
- Myoglobin
- Reference Values
- Seasons
- Sex Factors
- Uric Acid
- Ursidae
Keywords
- Asiatic black bear
- Ursus thibetanus
- blood chemistry
- health assessment
- hibernation
- reference values
Albumin (ALB) was a useful marker of nutrition and general health status. However, the conclusion about the association between ALB and diabetes was inconsistent, and little information was known about the elderly. A cohort study based on 18,384 army cadres was conducted Beijing, from 2009 to 2013. The mean age of the total 18,384 participants was 71±14years, and the mean ALB concentration was 44.33±3.94g/L at baseline. Diabetes incident showed an increasing trend according to the four ALB concentration groups, from 2.054% to 2.811% for incident. Cox regression showed that participants with higher ALB concentration were at increased HRs for diabetes incident. The HRs of ALB (per SD) and ALB concentration for diabetes were 1.125 (95% CI: 1.024-1.231) and 1.029 (95% CI: 1.007-1.051) respectively in the adjusted model. Also the HRs were closely related with BMI changes. For those who had a BMI changes<-1.00kg/m , the HRs were lower and not statistically significant, and for those with increasing BMI during an average of 4years' follow-up, the HRs were higher. There was a positive and independent association between baseline ALB concentrations with diabetes incident among Chinese male elderly, and this association was closely related with BMI changes.
MeSH Terms
- Aged
- Aged, 80 and over
- Aging
- Biomarkers
- Body Mass Index
- China
- Cohort Studies
- Diabetes Mellitus, Type 2
- Elder Nutritional Physiological Phenomena
- Follow-Up Studies
- Humans
- Incidence
- Male
- Middle Aged
- Military Personnel
- Proportional Hazards Models
- Retrospective Studies
- Serum Albumin, Human
- Up-Regulation
- Veterans
- Weight Gain
- Weight Loss
Keywords
- Albumin
- BMI
- China
- Cohort study
- Diabetes
- Elderly
This study aimed to establish a model that estimates the survival advantage at the molecular level based on telomere length and serum biomarkers of aging, to explore clinical significance. The study consisted of 100 healthy subjects and 40 type 2 diabetes mellitus patients, 20-90 years of age. Saliva telomere relative length (LnTL) was measured by the quantitative real-time polymerase chain reaction and the serum biochemical parameters, including albumin (ALB), total proteins, total cholesterol, triglycerides, and some enzyme parameters were detected by a biochemical analyzer. The Z values were transformed from mean values and standard deviations to estimate the survival advantage. A normal reference range (95% confidence interval) was set to the comprehensive advantage of the Z values (Z ) to evaluate the comprehensive survival advantage. The Z values of serum ALB and saliva LnTL could be used to estimate the survival advantage, and effectively distinguish between the aging and nonaging individuals. The Z was greater than 1.64 in the normal reference range, and type 2 diabetes mellitus patients had lower survival advantages compared to those of the control group (p < 0.05). Our two-dimensional model system using ALB and LnTL was valid and may have potential applications for evaluating the aging status at the molecular level, and for the observation of disease characteristics.
MeSH Terms
- Adult
- Aged
- Aged, 80 and over
- Aging
- Albumins
- Biomarkers
- Case-Control Studies
- Cholesterol
- Diabetes Mellitus
- Humans
- Middle Aged
- Survival Analysis
- Telomere Homeostasis
- Triglycerides
- Young Adult
Keywords
- Aging
- Albumin
- Survival advantage
- Telomere length
Blood samples from 172 captive and 40 wild, healthy, juvenile and adult, ploughshare tortoises ( Astrochelys yniphora ) were analyzed to determine hematological and biochemical reference intervals. Hematological analytes included packed cell volume (PCV), white blood cell count (WBC), and WBC differential estimates. Biochemical analysis included total protein measured by photometry (TP) and by refractometry (TPr), albumin (ALB), creatine kinase (CK), aspartate aminotransferase (AST), glutamate dehydrogenase (GLDH), bile acids (BA), calcium (Ca), phosphorus (P), urea (UREA), and uric acid (UA). The jugular vein was identified as the preferred venipuncture site as subcarapacial vein venipuncture resulted in regular hemodilution. In due consideration of small sample sizes in some of the groups studied, adult tortoises had significantly higher plasma GLDH activity and TPr, TP, ALB, BA, and UREA concentrations and significantly lower AST activity and P concentration than juveniles. Captivity had a significant influence in some reference intervals, with captive adults presenting significantly higher WBC, and estimated counts of all white cell types as well as UREA and TPr than wild counterparts. Captive juveniles also showed significantly higher estimated monocyte and lower estimated eosinophil and basophil counts. Although these differences most likely reflect local environmental or dietary differences, without representing pathology or a deviation from the normal, they question the applicability of reference values from captive animals to wild animals and vice versa. Significant sex differences were only observed for PCV and UA. The reported reference intervals may serve as benchmarks for clinical assessment and conservation of this critically endangered species.
MeSH Terms
- Aging
- Animal Husbandry
- Animals
- Blood Cell Count
- Breeding
- Calcium
- Endangered Species
- Female
- Male
- Phosphorus
- Reference Values
- Turtles
- Urea
- Uric Acid
Keywords
- Astrochelys yniphora
- biochemistry
- chelonia
- hematology
- ploughshare tortoise
- reference intervals
Is it possible to construct an age curve denoting the ages above which women are biologically too old to reproduce? We constructed a curve based on the distribution of female age at last birth in natural fertility populations reflecting the ages above which women have become biologically too old to have children. The median age at last birth (ALB) for females is ∼40-41 years of age across a range of natural fertility populations. This suggests that there is a fairly universal pattern of age-related fertility decline. However, little is known about the distribution of female ALB and in the present era of modern birth control, it is impossible to assess the age-specific distribution of ALB. Reliable information is lacking that could benefit couples who envisage delaying childbearing. This study is a review of high-quality historical data sets of natural fertility populations in which the distributions of female age at last birth were analysed. The studies selected used a retrospective cohort design where women were followed as they age through their reproductive years. Using a common set of eligibility criteria, large data files of natural fertility populations were prepared such that the analysis could be performed in parallel across all populations. Data on the ALB and confounding variables are presented as box and whisker plots denoting the 5th, 25th, 50th, 75th and 95th percentile distribution of the age at last birth for each population. The analysis includes the estimation of Kaplan-Meier curves for age at last birth of each population. The hazard curve for ALB was obtained by plotting the smoothed hazard curve of each population and taking the lowest hazard within a time period of at least 5 years. This lowest hazard curve was then transformed into a cumulative distribution function representing the composite curve of the end of biological fertility. This curve was based on the data from three of the six populations, having the lowest hazards of end of fertility. We selected six natural fertility populations comprising 58 051 eligible women. While these populations represent different historical time periods, the distribution of the ages at last birth is remarkably similar. The curve denoting the end of fertility indicates that <3% of women had their last birth at age 20 years meaning that almost 98% were able to have at least one child thereafter. The cumulative curve for the end of fertility slowly increases from 4.5% at age 25 years, 7% at age 30 years, 12% at age 35 years and 20% at age 38 years. Thereafter, it rises rapidly to about 50% at age 41, almost 90% at age 45 years and approaching 100% at age 50 years. It may be argued that these historical fertility data do not apply to the present time; however, the age-dependent decline in fertility is similar to current populations and is consistent with the pattern seen in women treated by donor insemination. Furthermore, for reproductive ageing, we note that it is unlikely that such a conserved biological process with a high degree of heritability would have changed significantly within a century or two. We argue that the age-specific ALB curve can be used to counsel couples who envisage having children in the future. Our findings challenge the unsubstantiated pessimism regarding the possibility of natural conception after age 35 years. No external funding was either sought or obtained for this study. There are no conflicts of interest to be declared.
MeSH Terms
- Adult
- Age Factors
- Aging
- Female
- Fertility
- Humans
- Middle Aged
- Retrospective Studies
Keywords
- delay of childbearing
- natural fertility
- ovarian ageing
- reproductive demography
- reproductive epidemiology