CDK18
Cyclin-dependent kinase 18 (EC 2.7.11.22) (Cell division protein kinase 18) (PCTAIRE-motif protein kinase 3) (Serine/threonine-protein kinase PCTAIRE-3) [PCTAIRE3] [PCTK3]
Publications[править]
Microarray gene expression data were used to analyze the expression pattern of cyclin, cyclin-dependent kinase (CDKs) and cyclin-dependent kinase inhibitor (CDKIs) genes from human pancreatic islets with and without type 2 diabetes (T2D). Of the cyclin genes, CCNI was the most expressed. Data obtained from microarray and qRT-PCR showed higher expression of CCND1 in diabetic islets. Among the CDKs, CDK4, CDK8 and CDK9 were highly expressed, while CDK1 was expressed at low level. High expression of [[CDK18]] was observed in diabetic islets. Of the CDKIs, CDKN1A expression was higher in diabetic islets in both microarray and qRT-PCR. Expression of CDKN1A, [[CDKN2A]], CCNI2, CDK3 and CDK16 was correlated with age. Finally, eight SNPs in these genes were associated with T2D in the DIAGRAM database. Our data provide a comprehensive expression pattern of cell cycle genes in human islets. More human studies are required to confirm and reproduce animal studies.
MeSH Terms
- Aged
- Aging
- Case-Control Studies
- Cells, Cultured
- Cyclin-Dependent Kinase Inhibitor Proteins
- Cyclin-Dependent Kinases
- Cyclins
- Diabetes Mellitus, Type 2
- Female
- Gene Expression Profiling
- Genes, cdc
- Genetic Association Studies
- Genetic Predisposition to Disease
- Humans
- Insulin
- Insulin Secretion
- Islets of Langerhans
- Male
- Middle Aged
- Oligonucleotide Array Sequence Analysis
- Polymorphism, Single Nucleotide
- Transcriptome