FBXO7

F-box only protein 7 [FBX7]

Publications

The FBXO7 homologue nutcracker and binding partner PI31 in Drosophila melanogaster models of Parkinson's disease.

PubMed

Full text

Parkinsonian-pyramidal syndrome (PPS) is an early onset form of Parkinson's disease (PD) that shows degeneration of the extrapyramidal region of the brain to result in a severe form of PD. The toxic protein build-up has been implicated in the onset of PPS. Protein removal is mediated by an intracellular proteasome complex: an E3 ubiquitin ligase, the targeting component, is essential for function. FBXO7 encodes the F-box component of the SCF E3 ubiquitin ligase linked to familial forms of PPS. The Drosophila melanogaster homologue nutcracker (ntc) and a binding partner, PI31, have been shown to be active in proteasome function. We show that altered expression of either ntc or PI31 in dopaminergic neurons leads to a decrease in longevity and locomotor ability, phenotypes both associated with models of PD. Furthermore, expression of ntc-RNAi in an established α-synuclein-dependent model of PD rescues the phenotypes of diminished longevity and locomotor control.

MeSH Terms

• Animals
• Animals, Genetically Modified
• Carrier Proteins
• Disease Models, Animal
• Drosophila Proteins
• Drosophila melanogaster
• Eye
• F-Box Proteins
• Female
• Gene Expression
• Longevity
• Male
• Organ Specificity
• Organogenesis
• Parkinson Disease
• Protein Binding
• Protein Interaction Domains and Motifs
• alpha-Synuclein

Keywords

• Drosophila melanogaster
• FBXO7
• PI31
• Parkinson Disease
• maladie de Parkinson
• neurodegeneration
• neurodégénérescence
• nutcracker