CDK3

Cyclin-dependent kinase 3 (EC 2.7.11.22) (Cell division protein kinase 3) [CDKN3]

Publications

Expression profiling of cell cycle genes in human pancreatic islets with and without type 2 diabetes.

PubMed

Full text

Microarray gene expression data were used to analyze the expression pattern of cyclin, cyclin-dependent kinase (CDKs) and cyclin-dependent kinase inhibitor (CDKIs) genes from human pancreatic islets with and without type 2 diabetes (T2D). Of the cyclin genes, CCNI was the most expressed. Data obtained from microarray and qRT-PCR showed higher expression of CCND1 in diabetic islets. Among the CDKs, CDK4, CDK8 and CDK9 were highly expressed, while CDK1 was expressed at low level. High expression of [[CDK18]] was observed in diabetic islets. Of the CDKIs, CDKN1A expression was higher in diabetic islets in both microarray and qRT-PCR. Expression of CDKN1A, [[CDKN2A]], CCNI2, CDK3 and CDK16 was correlated with age. Finally, eight SNPs in these genes were associated with T2D in the DIAGRAM database. Our data provide a comprehensive expression pattern of cell cycle genes in human islets. More human studies are required to confirm and reproduce animal studies.

MeSH Terms

• Aged
• Aging
• Case-Control Studies
• Cells, Cultured
• Cyclin-Dependent Kinase Inhibitor Proteins
• Cyclin-Dependent Kinases
• Cyclins
• Diabetes Mellitus, Type 2
• Female
• Gene Expression Profiling
• Genes, cdc
• Genetic Association Studies
• Genetic Predisposition to Disease
• Humans
• Insulin
• Insulin Secretion
• Islets of Langerhans
• Male
• Middle Aged
• Oligonucleotide Array Sequence Analysis
• Polymorphism, Single Nucleotide
• Transcriptome