Редактирование: MBIP

MAP3K12-binding inhibitory protein 1 (MAPK upstream kinase-binding inhibitory protein) (MUK-binding inhibitory protein) [BM-015]

==Publications==

{{medline-entry
|title=Long-term caloric restriction ameliorates the decline in diastolic function in humans.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/16412867
|abstract=We determined whether caloric restriction (CR) has cardiac-specific effects that attenuate the established aging-associated impairments in diastolic function (DF). Caloric restriction retards the aging process in small mammals; however, no information is available on the effects of long-term CR on human aging. In healthy individuals, Doppler echocardiography has established the pattern of aging-associated DF impairment, whereas little change is observed in systolic function (SF). Diastolic function was assessed in 25 subjects (age 53  /- 12 years) practicing CR for 6.5  /- 4.6 years and 25 age- and gender-matched control subjects consuming Western diets. Diastolic function was quantified by transmitral flow, Doppler tissue imaging, and model-based image processing ([[MBIP]]) of E waves. C-reactive protein ([[CRP]]), tumor necrosis factor-alpha ([[TNF]]-alpha), and transforming growth factor-beta1 (TGF-beta1) were also measured. No difference in SF was observed between groups; however, standard transmitral Doppler flow DF indexes of the CR group were similar to those of younger individuals, and [[MBIP]]-based, flow-derived DF indexes, reflecting chamber viscoelasticity and stiffness, were significantly lower than in control subjects. Blood pressure, serum [[CRP]], [[TNF]]-alpha, and TGF-beta(1) levels were significantly lower in the CR group (102  /- 10/61  /- 7 mm Hg, 0.3  /- 0.3 mg/l, 0.8  /- 0.5 pg/ml, 29.4  /- 6.9 ng/ml, respectively) compared with the Western diet group (131  /- 11/83  /- 6 mm Hg, 1.9  /- 2.8 mg/l, 1.5  /- 1.0 pg/ml, 35.4  /- 7.1 ng/ml, respectively). Caloric restriction has cardiac-specific effects that ameliorate aging-associated changes in DF. These beneficial effects on cardiac function might be mediated by the effect of CR on blood pressure, systemic inflammation, and myocardial fibrosis.
|mesh-terms=* Adult
* Aged
* Aged, 80 and over
* Aging
* C-Reactive Protein
* Caloric Restriction
* Cross-Sectional Studies
* Diastole
* Echocardiography, Doppler
* Female
* Humans
* Image Processing, Computer-Assisted
* Male
* Middle Aged
* Systole
* Transforming Growth Factor beta
* Transforming Growth Factor beta1
* Tumor Necrosis Factor-alpha

|full-text-url=https://sci-hub.do/10.1016/j.jacc.2005.08.069
}}