Редактирование: Aging genes 60-69 (раздел)

==LMNA==

* {{medline-title
|title=Metformin alters peripheral blood mononuclear cells (PBMC) senescence biomarkers gene expression in type 2 diabetic patients.
|date=01.2021
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/33187870
|full-text-url=https://sci-hub.do/10.1016/j.jdiacomp.2020.107758
}}
* {{medline-title
|title=Protein structural and mechanistic basis of progeroid laminopathies.
|date=16.08.2020
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32799420
|full-text-url=https://sci-hub.do/10.1111/febs.15526
}}
* {{medline-title
|title=Towards delineating the chain of events that cause premature senescence in the accelerated aging syndrome Hutchinson-Gilford progeria (HGPS).
|date=30.06.2020
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32539085
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7329345
}}
* {{medline-title
|title=Progerin Expression Induces Inflammation, Oxidative Stress and Senescence in Human Coronary Endothelial Cells.
|date=12.05.2020
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32408587
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7290406
}}
* {{medline-title
|title=The JAK1/2 inhibitor ruxolitinib delays premature aging phenotypes.
|date=04.2020
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32196928
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7189991
}}
* {{medline-title
|title=Pharmacotherapy to gene editing: potential therapeutic approaches for Hutchinson-Gilford progeria syndrome.
|date=04.2020
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32048129
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7205988
}}
* {{medline-title
|title=Long term breeding of the Lmna G609G progeric mouse: Characterization of homozygous and heterozygous models.
|date=02.2020
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31794853
|full-text-url=https://sci-hub.do/10.1016/j.exger.2019.110784
}}
* {{medline-title
|title=Epigenetic signatures of Werner syndrome occur early in life and are distinct from normal epigenetic aging processes.
|date=10.2019
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31259468
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6718529
}}
* {{medline-title
|title=Transient introduction of human telomerase mRNA improves hallmarks of progeria cells.
|date=08.2019
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31152494
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6612639
}}
* {{medline-title
|title=A humanized yeast system to analyze cleavage of prelamin A by [[ZMPSTE24]].
|date=15.03.2019
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/30625386
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6401292
}}
* {{medline-title
|title=Impaired immune surveillance accelerates accumulation of senescent cells and aging.
|date=21.12.2018
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/30575733
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6303397
}}
* {{medline-title
|title=Endothelial progerin expression causes cardiovascular pathology through an impaired mechanoresponse.
|date=01.02.2019
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/30422822
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6355303
}}
* {{medline-title
|title=Targeting the phospholipase A2 receptor ameliorates premature aging phenotypes.
|date=12.2018
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/30216637
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6260922
}}
* {{medline-title
|title=Altered modulation of lamin A/C-[[HDAC2]] interaction and p21 expression during oxidative stress response in HGPS.
|date=10.2018
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/30109767
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6156291
}}
* {{medline-title
|title=Cellular stress and AMPK activation as a common mechanism of action linking the effects of metformin and diverse compounds that alleviate accelerated aging defects in Hutchinson-Gilford progeria syndrome.
|date=09.2018
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/30037605
|full-text-url=https://sci-hub.do/10.1016/j.mehy.2018.06.029
}}
* {{medline-title
|title=Proteomic changes during adult stage in pre-optic, hypothalamus, hippocampus and pituitary regions of female rat brain following neonatal exposure to estradiol-17β.
|date=15.09.2018
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/29777688
|full-text-url=https://sci-hub.do/10.1016/j.ygcen.2018.05.005
}}
* {{medline-title
|title=RECQ helicase disease and related progeroid syndromes: RECQ2018 meeting.
|date=07.2018
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/29752965
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6217841
}}
* {{medline-title
|title=Upregulation of the aging related [[LMNA]] splice variant progerin in dilated cardiomyopathy.
|date=2018
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/29702688
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5922532
}}
* {{medline-title
|title=Increasing autophagy and blocking Nrf2 suppress laminopathy-induced age-dependent cardiac dysfunction and shortened lifespan.
|date=06.2018
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/29575479
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5946079
}}
* {{medline-title
|title=Lipodystrophic syndromes due to [[LMNA]] mutations: recent developments on biomolecular aspects, pathophysiological hypotheses and therapeutic perspectives.
|date=01.01.2018
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/29578370
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5973242
}}
* {{medline-title
|title=Differential stem cell aging kinetics in Hutchinson-Gilford progeria syndrome and Werner syndrome.
|date=04.2018
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/29476423
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5876188
}}
* {{medline-title
|title=Mandibuloacral dysplasia: A premature ageing disease with aspects of physiological ageing.
|date=03.2018
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/29208544
|full-text-url=https://sci-hub.do/10.1016/j.arr.2017.12.001
}}
* {{medline-title
|title=Hutchinson-Gilford Progeria Syndrome: A Premature Aging Disease.
|date=05.2018
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/28660486
|full-text-url=https://sci-hub.do/10.1007/s12035-017-0610-7
}}
* {{medline-title
|title=Progerin-Induced Replication Stress Facilitates Premature Senescence in Hutchinson-Gilford Progeria Syndrome.
|date=15.07.2017
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/28483909
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5492170
}}
* {{medline-title
|title=Physiological and Pathological Aging Affects Chromatin Dynamics, Structure and Function at the Nuclear Edge.
|date=2016
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/27602048
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4993774
}}
* {{medline-title
|title=Clinical Trial of the Protein Farnesylation Inhibitors Lonafarnib, Pravastatin, and Zoledronic Acid in Children With Hutchinson-Gilford Progeria Syndrome.
|date=12.07.2016
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/27400896
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4943677
}}
* {{medline-title
|title=Hutchinson-Gilford Progeria Syndrome: A premature aging disease caused by [[LMNA]] gene mutations.
|date=01.2017
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/27374873
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5195863
}}
* {{medline-title
|title=Progeria and the early aging in children: a case report.
|date=17.02.2016
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/27267192

}}
* {{medline-title
|title=A Heterozygous [[ZMPSTE24]] Mutation Associated with Severe Metabolic Syndrome, Ectopic Fat Accumulation, and Dilated Cardiomyopathy.
|date=25.04.2016
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/27120622
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4931670
}}
* {{medline-title
|title=Understanding Vascular Diseases: Lessons From Premature Aging Syndromes.
|date=05.2016
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/26948039
|full-text-url=https://sci-hub.do/10.1016/j.cjca.2015.12.003
}}
* {{medline-title
|title=Molecular insights into the premature aging disease progeria.
|date=04.2016
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/26847180
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4796323
}}
* {{medline-title
|title=[[LMNA]] mutations resulting in lipodystrophy and HIV protease inhibitors trigger vascular smooth muscle cell senescence and calcification: Role of [[ZMPSTE24]] downregulation.
|date=02.2016
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/26724531
|full-text-url=https://sci-hub.do/10.1016/j.atherosclerosis.2015.12.012
}}
* {{medline-title
|title=Methylene blue alleviates nuclear and mitochondrial abnormalities in progeria.
|date=04.2016
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/26663466
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4783354
}}
* {{medline-title
|title=Pluripotent stem cells to model Hutchinson-Gilford progeria syndrome (HGPS): Current trends and future perspectives for drug discovery.
|date=11.2015
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/26474742
|full-text-url=https://sci-hub.do/10.1016/j.arr.2015.10.002
}}
* {{medline-title
|title=All-trans retinoic acid and rapamycin normalize Hutchinson Gilford progeria fibroblast phenotype.
|date=06.10.2015
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/26359359
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4745772
}}
* {{medline-title
|title=New look at the role of progerin in skin aging.
|date=03.2015
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/26327889
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4440198
}}
* {{medline-title
|title=Progerin reduces LAP2α-telomere association in Hutchinson-Gilford progeria.
|date=27.08.2015
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/26312502
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4565980
}}
* {{medline-title
|title=Overexpression of Lamin B Receptor Results in Impaired Skin Differentiation.
|date=2015
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/26053873
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4459694
}}
* {{medline-title
|title=Sustained accumulation of prelamin A and depletion of lamin A/C both cause oxidative stress and mitochondrial dysfunction but induce different cell fates.
|date=2015
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/25996284
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4615646
}}
* {{medline-title
|title=Age-Related Lipid Metabolic Signature in Human [[LMNA]]-Lipodystrophic Stem Cell-Derived Adipocytes.
|date=07.2015
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/25961135
|full-text-url=https://sci-hub.do/10.1210/jc.2014-4528
}}
* {{medline-title
|title=Transgene silencing of the Hutchinson-Gilford progeria syndrome mutation results in a reversible bone phenotype, whereas resveratrol treatment does not show overall beneficial effects.
|date=08.2015
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/25877214
|full-text-url=https://sci-hub.do/10.1096/fj.14-269217
}}
* {{medline-title
|title=Sulforaphane enhances progerin clearance in Hutchinson-Gilford progeria fibroblasts.
|date=02.2015
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/25510262
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4326906
}}
* {{medline-title
|title=Expression of progerin in aging mouse brains reveals structural nuclear abnormalities without detectible significant alterations in gene expression, hippocampal stem cells or behavior.
|date=01.03.2015
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/25343989
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4321440
}}
* {{medline-title
|title=Accumulation of prelamin A compromises NF-κB-regulated B-lymphopoiesis in a progeria mouse model.
|date=2013
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/24764515
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3922919
}}
* {{medline-title
|title=Prelamin A accumulation and stress conditions induce impaired Oct-1 activity and autophagy in prematurely aged human mesenchymal stem cell.
|date=04.2014
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/24753226
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4032794
}}
* {{medline-title
|title=Antagonistic functions of [[LMNA]] isoforms in energy expenditure and lifespan.
|date=05.2014
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/24639560
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4210101
}}
* {{medline-title
|title=Epigenetic involvement in Hutchinson-Gilford progeria syndrome: a mini-review.
|date=2014
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/24603298
|full-text-url=https://sci-hub.do/10.1159/000357206
}}
* {{medline-title
|title=RB and lamins in cell cycle regulation and aging.
|date=2014
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/24563346
|full-text-url=https://sci-hub.do/10.1007/978-1-4899-8032-8_6
}}
* {{medline-title
|title=Search and insights into novel genetic alterations leading to classical and atypical Werner syndrome.
|date=2014
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/24401204
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3997596
}}
* {{medline-title
|title=Mapping disease-related missense mutations in the immunoglobulin-like fold domain of lamin A/C reveals novel genotype-phenotype associations for laminopathies.
|date=06.2014
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/24375749
|full-text-url=https://sci-hub.do/10.1002/prot.24465
}}
* {{medline-title
|title=Investigation of age-related changes in [[LMNA]] splicing and expression of progerin in human skeletal muscles.
|date=2013
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/24294364
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3843258
}}
* {{medline-title
|title=Investigation of splicing changes and post-translational processing of [[LMNA]] in sporadic inclusion body myositis.
|date=2013
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/24040437
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3759479
}}
* {{medline-title
|title=Identification of mitochondrial dysfunction in Hutchinson-Gilford progeria syndrome through use of stable isotope labeling with amino acids in cell culture.
|date=08.10.2013
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/23969228
|full-text-url=https://sci-hub.do/10.1016/j.jprot.2013.08.008
}}
* {{medline-title
|title=The contrasting roles of lamin B1 in cellular aging and human disease.
|date=07-08.2013
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/23873483
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3810336
}}
* {{medline-title
|title=Depleting the methyltransferase Suv39h1 improves DNA repair and extends lifespan in a progeria mouse model.
|date=2013
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/23695662
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3674265
}}
* {{medline-title
|title=Hutchinson-Gilford progeria syndrome through the lens of transcription.
|date=08.2013
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/23496208
|full-text-url=https://sci-hub.do/10.1111/acel.12070
}}
* {{medline-title
|title=Genetic and clinical characteristics of skeletal and cardiac muscle in patients with lamin A/C gene mutations.
|date=08.2013
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/23450819
|full-text-url=https://sci-hub.do/10.1002/mus.23827
}}
* {{medline-title
|title=Modeling of lamin A/C mutation premature cardiac aging using patient‐specific induced pluripotent stem cells.
|date=11.2012
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/23362510
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3560431
}}
* {{medline-title
|title=Aberrant DNA methylation profiles in the premature aging disorders Hutchinson-Gilford Progeria and Werner syndrome.
|date=01.2013
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/23257959
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3549877
}}
* {{medline-title
|title=Resveratrol rescues [[SIRT1]]-dependent adult stem cell decline and alleviates progeroid features in laminopathy-based progeria.
|date=05.12.2012
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/23217256
|full-text-url=https://sci-hub.do/10.1016/j.cmet.2012.11.007
}}