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Aging genes 70-79
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==H2AX== * {{medline-title |title=[[REV1]] inhibitor JH-RE-06 enhances tumor cell response to chemotherapy by triggering senescence hallmarks. |date=17.11.2020 |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/33168727 |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7682577 }} * {{medline-title |title=A Small Molecule Stabilizer of the [[MYC]] G4-Quadruplex Induces Endoplasmic Reticulum Stress, Senescence and Pyroptosis in Multiple Myeloma. |date=13.10.2020 |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/33066043 |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7650714 }} * {{medline-title |title=Exposing human primary dermal fibroblasts to particulate matter induces changes associated with skin aging. |date=11.2020 |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32915475 |full-text-url=https://sci-hub.do/10.1096/fj.202001357R }} * {{medline-title |title=Evaluation of Gamma[[H2AX]] in Buccal Cells as a Molecular Biomarker of DNA Damage in Alzheimer's Disease in the AIBL Study of Ageing. |date=06.08.2020 |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32781776 |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7459751 }} * {{medline-title |title=Doxorubicin generates senescent microglia that exhibit altered proteomes, higher levels of cytokine secretion, and a decreased ability to internalize amyloid β. |date=15.10.2020 |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32738344 |full-text-url=https://sci-hub.do/10.1016/j.yexcr.2020.112203 }} * {{medline-title |title=Cisplatin-induced peripheral neuropathy is associated to neuronal senescence-like response. |date=29.06.2020 |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32597980 |full-text-url=https://sci-hub.do/10.1093/neuonc/noaa151 }} * {{medline-title |title=Extended in vitro culture of primary human mesenchymal stem cells downregulates Brca1-related genes and impairs DNA double-strand break recognition. |date=07.2020 |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32333827 |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7327915 }} * {{medline-title |title=Irradiation-induced senescence of bone marrow mesenchymal stem cells aggravates osteogenic differentiation dysfunction via paracrine signaling. |date=01.05.2020 |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32233952 |full-text-url=https://sci-hub.do/10.1152/ajpcell.00520.2019 }} * {{medline-title |title=Guanine Deaminase Stimulates Ultraviolet-induced Keratinocyte Senescence in Seborrhoeic Keratosis via Guanine Metabolites. |date=06.04.2020 |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32215662 |full-text-url=https://sci-hub.do/10.2340/00015555-3473 }} * {{medline-title |title=The [[RXFP3]] receptor is functionally associated with cellular responses to oxidative stress and DNA damage. |date=03.12.2019 |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31794429 |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6932917 }} * {{medline-title |title=Do [[BRCA1]] and [[BRCA2]] gene mutation carriers have a reduced ovarian reserve? Protocol for a prospective observational study. |date=25.11.2019 |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31772111 |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6887091 }} * {{medline-title |title=Slower rates of accumulation of DNA damage in leukocytes correlate with longer lifespans across several species of birds and mammals. |date=15.11.2019 |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31730540 |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6874430 }} * {{medline-title |title=Phosphoproteomic analysis reveals plant DNA damage signalling pathways with a functional role for histone [[H2AX]] phosphorylation in plant growth under genotoxic stress. |date=12.2019 |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31410901 |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6900162 }} * {{medline-title |title=Rag1 immunodeficiency-induced early aging and senescence in zebrafish are dependent on chronic inflammation and oxidative stress. |date=10.2019 |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31348603 |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6718522 }} * {{medline-title |title=Are There Common Mechanisms Between the Hutchinson-Gilford Progeria Syndrome and Natural Aging? |date=2019 |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31156709 |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6529819 }} * {{medline-title |title=Epigallocatechin-3-gallate induces telomere shortening and clastogenic damage in glioblastoma cells. |date=10.2019 |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31026358 |full-text-url=https://sci-hub.do/10.1002/em.22295 }} * {{medline-title |title=Expression of [[RNF8]] on cochlear apoptosis and aging in mice of different ages. |date=03-Apr,.2019 |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/30915826 }} * {{medline-title |title=Mitochondrial Protection Partly Mitigates Kidney Cellular Senescence in Swine Atherosclerotic Renal Artery Stenosis. |date=2019 |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/30907989 |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6519989 }} * {{medline-title |title=Old age increases microglial senescence, exacerbates secondary neuroinflammation, and worsens neurological outcomes after acute traumatic brain injury in mice. |date=05.2019 |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/30904769 |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6486858 }} * {{medline-title |title=Avenanthramide A Induces Cellular Senescence via miR-129-3p/Pirh2/p53 Signaling Pathway To Suppress Colon Cancer Growth. |date=01.05.2019 |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/30888162 |full-text-url=https://sci-hub.do/10.1021/acs.jafc.9b00833 }} * {{medline-title |title=PFG acted as an inducer of premature senescence in TIG-1 normal diploid fibroblast and an inhibitor of mitosis in the HeLa cells. |date=06.2019 |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/30836860 |full-text-url=https://sci-hub.do/10.1080/09168451.2019.1585744 }} * {{medline-title |title=[[S100A13]] promotes senescence-associated secretory phenotype and cellular senescence via modulation of non-classical secretion of IL-1α. |date=23.01.2019 |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/30670674 |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6366962 }} * {{medline-title |title=Clostridium difficile toxin B induces senescence in enteric glial cells: A potential new mechanism of Clostridium difficile pathogenesis. |date=12.2018 |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/30296499 |full-text-url=https://sci-hub.do/10.1016/j.bbamcr.2018.10.007 }} * {{medline-title |title=Varenicline reduces DNA damage, tau mislocalization and post surgical cognitive impairment in aged mice. |date=12.2018 |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/30273594 |full-text-url=https://sci-hub.do/10.1016/j.neuropharm.2018.09.044 }} * {{medline-title |title=The activated DNA double-strand break repair pathway in cumulus cells from aging patients may be used as a convincing predictor of poor outcomes after in vitro fertilization-embryo transfer treatment. |date=2018 |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/30235328 |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6147527 }} * {{medline-title |title=Micro-RNAS Regulate Metabolic Syndrome-induced Senescence in Porcine Adipose Tissue-derived Mesenchymal Stem Cells through the P16/MAPK Pathway. |date=10.2018 |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/30187775 |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6180720 }} * {{medline-title |title=Acetylation of PGC1α by Histone Deacetylase 1 Downregulation Is Implicated in Radiation-Induced Senescence of Brain Endothelial Cells. |date=16.05.2019 |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/30016403 |full-text-url=https://sci-hub.do/10.1093/gerona/gly167 }} * {{medline-title |title=Role of accelerated aging in limb muscle wasting of patients with COPD. |date=2018 |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/29970961 |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6022820 }} * {{medline-title |title=[Protective effect of Wuzi Yanzong recipe on testicular DNA damage and apoptosis in natural ageing rats]. |date=04.2018 |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/29751716 |full-text-url=https://sci-hub.do/10.19540/j.cnki.cjcmm.20180115.005 }} * {{medline-title |title=Replication Stress Shapes a Protective Chromatin Environment across Fragile Genomic Regions. |date=04.01.2018 |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/29249653 |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5756112 }} * {{medline-title |title=Thioredoxin mitigates radiation-induced hematopoietic stem cell injury in mice. |date=15.11.2017 |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/29141658 |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5688691 }} * {{medline-title |title=Therapeutic doses of doxorubicin induce premature senescence of human mesenchymal stem cells derived from menstrual blood, bone marrow and adipose tissue. |date=03.2018 |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/29022209 |full-text-url=https://sci-hub.do/10.1007/s12185-017-2346-6 }} * {{medline-title |title=Hydrogen-rich pure water prevents cigarette smoke-induced pulmonary emphysema in SMP30 knockout mice. |date=07.10.2017 |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/28807355 |full-text-url=https://sci-hub.do/10.1016/j.bbrc.2017.08.035 }} * {{medline-title |title=The Cytolethal Distending Toxin Subunit CdtB of [i]Helicobacter hepaticus[/i] Promotes Senescence and Endoreplication in Xenograft Mouse Models of Hepatic and Intestinal Cell Lines. |date=2017 |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/28713773 |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5491915 }} * {{medline-title |title=Increased level of DNA damage in some organs of obese Zucker rats by γ-[[H2AX]] analysis. |date=08.2017 |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/28714549 |full-text-url=https://sci-hub.do/10.1002/em.22115 }} * {{medline-title |title=[The Role of DNA Double-strain Damage Repairing Mechanisms in Diabetic Atheroscolersis]. |date=03.2017 |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/28612525 }} * {{medline-title |title=DNA damage marker phosphorylated histone [[H2AX]] is a potential predictive marker for progression of epithelial dysplasia of the oral cavity. |date=10.2017 |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/28543539 |full-text-url=https://sci-hub.do/10.1111/his.13260 }} * {{medline-title |title=Tumor stroma with senescence-associated secretory phenotype in steatohepatitic hepatocellular carcinoma. |date=2017 |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/28273155 |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5342190 }} * {{medline-title |title=Metformin alleviates ageing cellular phenotypes in Hutchinson-Gilford progeria syndrome dermal fibroblasts. |date=10.2017 |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/28192606 |full-text-url=https://sci-hub.do/10.1111/exd.13323 }} * {{medline-title |title=Impact of lysosomal storage disorders on biology of mesenchymal stem cells: Evidences from in vitro silencing of glucocerebrosidase ([[GBA]]) and alpha-galactosidase A ([[GLA]]) enzymes. |date=12.2017 |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/28098348 |full-text-url=https://sci-hub.do/10.1002/jcp.25807 }} * {{medline-title |title=Liver damage and senescence increases in patients developing hepatocellular carcinoma. |date=08.2017 |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/28052383 |full-text-url=https://sci-hub.do/10.1111/jgh.13717 }} * {{medline-title |title=The Chromatin-Associated Phf12 Protein Maintains Nucleolar Integrity and Prevents Premature Cellular Senescence. |date=01.03.2017 |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/27956701 |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5311238 }} * {{medline-title |title=Axitinib induces senescence-associated cell death and necrosis in glioma cell lines: The proteasome inhibitor, bortezomib, potentiates axitinib-induced cytotoxicity in a p21(Waf/Cip1) dependent manner. |date=10.01.2017 |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/27926485 |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5356889 }} * {{medline-title |title=Detection of Dysfunctional Telomeres in Oncogene-Induced Senescence. |date=2017 |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/27812868 |full-text-url=https://sci-hub.do/10.1007/978-1-4939-6670-7_6 }} * {{medline-title |title=Transgenic expression of cyclooxygenase-2 (COX2) causes premature aging phenotypes in mice. |date=07.10.2016 |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/27750221 |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5115895 }} * {{medline-title |title=Overexpression of catalase in mice reduces age-related oxidative stress and maintains sperm production. |date=11.2016 |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/27575890 |full-text-url=https://sci-hub.do/10.1016/j.exger.2016.08.012 }} * {{medline-title |title=BRCA-1 Gene Expression and Comparative Proteomic Profile of Primordial Follicles from Young and Adult Buffalo (Bubalus bubalis) Ovaries. |date=03.04.2017 |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/27552356 |full-text-url=https://sci-hub.do/10.1080/10495398.2016.1210613 }} * {{medline-title |title=In vitro model for DNA double-strand break repair analysis in breast cancer reveals cell type-specific associations with age and prognosis. |date=11.2016 |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/27494941 |full-text-url=https://sci-hub.do/10.1096/fj.201600453R }} * {{medline-title |title=Effects of Aging and Oxidative Stress on Spermatozoa of Superoxide-Dismutase 1- and Catalase-Null Mice. |date=09.2016 |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/27465136 |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5333935 }} * {{medline-title |title=Growth arrest of lung carcinoma cells (A549) by polyacrylate-anchored peroxovanadate by activating Rac1-NADPH oxidase signalling axis. |date=09.2016 |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/27435854 |full-text-url=https://sci-hub.do/10.1007/s11010-016-2761-7 }} * {{medline-title |title=p53-Dependent DNA damage response sensitive to editing-defective tRNA synthetase in zebrafish. |date=26.07.2016 |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/27402763 |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4968768 }} * {{medline-title |title=Mesenchymal stromal cells having inactivated [[RB1]] survive following low irradiation and accumulate damaged DNA: Hints for side effects following radiotherapy. |date=02.2017 |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/27124644 |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5323029 }} * {{medline-title |title=The impact of autophagy on cell death modalities in CRL-5876 lung adenocarcinoma cells after their exposure to γ-rays and/or erlotinib. |date=04.2016 |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/27026538 |full-text-url=https://sci-hub.do/10.1007/s10565-016-9319-z }} * {{medline-title |title=Dehydroleucodine inhibits tumor growth in a preclinical melanoma model by inducing cell cycle arrest, senescence and apoptosis. |date=01.03.2016 |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/26718258 |full-text-url=https://sci-hub.do/10.1016/j.canlet.2015.12.004 }} * {{medline-title |title=SNEV(Prp19/PSO4) deficiency increases PUVA-induced senescence in mouse skin. |date=03.2016 |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/26663487 |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4832318 }} * {{medline-title |title=Persistent γ[[H2AX]]: A promising molecular marker of DNA damage and aging. |date=10-12.2015 |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/26596544 |full-text-url=https://sci-hub.do/10.1016/j.mrrev.2015.07.001 }} * {{medline-title |title=Axitinib induces DNA damage response leading to senescence, mitotic catastrophe, and increased NK cell recognition in human renal carcinoma cells. |date=03.11.2015 |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/26474283 |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4742174 }} * {{medline-title |title=Comparative proteomic analysis of primordial follicles from ovaries of immature and aged rats. |date=2015 |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/26391928 |full-text-url=https://sci-hub.do/10.3109/19396368.2015.1077903 }} * {{medline-title |title=Ablation of XP-V gene causes adipose tissue senescence and metabolic abnormalities. |date=18.08.2015 |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/26240351 |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4547227 }} * {{medline-title |title=Impairing the radioresistance of cancer cells by hydrogenated nanodiamonds. |date=08.2015 |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/26010122 |full-text-url=https://sci-hub.do/10.1016/j.biomaterials.2015.05.034 }} * {{medline-title |title=Long-term arsenite exposure induces premature senescence in B cell lymphoma A20 cells. |date=04.2016 |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/25787150 |full-text-url=https://sci-hub.do/10.1007/s00204-015-1500-2 }} * {{medline-title |title=Changes in the expression of DNA double strand break repair genes in primordial follicles from immature and aged rats. |date=03.2015 |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/25599822 |full-text-url=https://sci-hub.do/10.1016/j.rbmo.2014.11.010 }} * {{medline-title |title=Long-term Neuroglial Cocultures as a Brain Aging Model: Hallmarks of Senescence, MicroRNA Expression Profiles, and Comparison With In Vivo Models. |date=01.2016 |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/25568096 |full-text-url=https://sci-hub.do/10.1093/gerona/glu231 }} * {{medline-title |title=Loss of Nfkb1 leads to early onset aging. |date=11.2014 |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/25553648 |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4276787 }} * {{medline-title |title=Oxidative Glial Cell Damage Associated with White Matter Lesions in the Aging Human Brain. |date=09.2015 |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/25311358 |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4861214 }} * {{medline-title |title=Gallotannin is a DNA damaging compound that induces senescence independently of p53 and p21 in human colon cancer cells. |date=10.2015 |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/24798519 |full-text-url=https://sci-hub.do/10.1002/mc.22172 }} * {{medline-title |title=Oxidative DNA damage causes premature senescence in mouse embryonic fibroblasts deficient for Krüppel-like factor 4. |date=09.2015 |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/24788960 |full-text-url=https://sci-hub.do/10.1002/mc.22161 }} * {{medline-title |title=HP1α mediates defective heterochromatin repair and accelerates senescence in Zmpste24-deficient cells. |date=2014 |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/24584199 |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4049960 }} * {{medline-title |title=Wild-type p53-induced phosphatase 1 (Wip1) forestalls cellular premature senescence at physiological oxygen levels by regulating DNA damage response signaling during DNA replication. |date=2014 |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/24552809 |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3984300 }} * {{medline-title |title=[Correlation between DNA damage and EB virus infection in nasopharyngeal carcinoma]. |date=02.2014 |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/24491061 }} * {{medline-title |title=Phosphorylation of histone [[H2AX]] in the mouse brain from development to senescence. |date=21.01.2014 |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/24451138 |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3907886 }} * {{medline-title |title=Mapping NAD( ) metabolism in the brain of ageing Wistar rats: potential targets for influencing brain senescence. |date=04.2014 |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/24337988 |full-text-url=https://sci-hub.do/10.1007/s10522-013-9489-5 }} * {{medline-title |title=Rac1 modulates acute and subacute genotoxin-induced hepatic stress responses, fibrosis and liver aging. |date=21.03.2013 |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/23519127 |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3613835 }} * {{medline-title |title=Primary human muscle precursor cells obtained from young and old donors produce similar proliferative, differentiation and senescent profiles in culture. |date=06.2013 |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/23374245 |full-text-url=https://sci-hub.do/10.1111/acel.12051 }}
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